pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pilot Study of Anti-CD20-CAR-engineered T Cells in Patients With Chemotherapy Resistant or Refractory CD20+ Lymphoma
Status: UNKNOWN
Conditions: Lymphoma, B-Cell
Interventions: BIOLOGICAL: CART20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Staph Aureus Carriage by Non-Antibiotic NOZIN® Nasal Sanitizer® Antiseptic
Status: COMPLETED
Conditions: Infectious Disease
Interventions: OTHER: Nozin® Nasal Sanitizer®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Angiocal® in Patients With Solid Tumors, Investigating Safety, Tolerability, Blood Concentration of Study Drug
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Angiocal® (PRS-050-PEG40)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidural Pulsed Radiofrequency Treatment in Failed Back Surgery Syndrome
Status: NOT_YET_RECRUITING
Conditions: Back Pain|Failed Back Surgery Syndrome|Neuropathic Pain
Interventions: PROCEDURE: Epidural pulsed radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of TachoSil® on Incidence of Symptomatic and Radiographic Lymphoceles After Extended Pelvic Lymph Node Dissection in Prostate and Bladder Cancer.
Status: COMPLETED
Conditions: Prostate or Bladder Cancer
Interventions: DRUG: 1 TachoSil hemostatic sponge (9,5 cm x 4,8 cm) placed on each side on the external iliac artery.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Increasing Doses of Combretasatin A1 Diphosphate (OXi4503) as Monotherapy in Subjects With Hepatic Tumor Burden
Status: COMPLETED
Conditions: Neoplasm Metastasis
Interventions: DRUG: Combretastatin A1 Diphosphate (OXi4503)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Dosing Regimen for Posaconazole Prophylaxis in Children Based on Body Surface Area
Status: COMPLETED
Conditions: Hematological Malignancy
Interventions: DRUG: Posaconazole prophylaxis 120 mg/m² tid|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Physiotherapists' Placebo or Nocebo Communication Regarding VR in CMP
Status: NOT_YET_RECRUITING
Conditions: Communication|Chronic Pain
Interventions: OTHER: Video placebo communication|OTHER: Video nocebo communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Multipolar Radiofrequency Ablation for Hepatocellular Carcinoma Using Extra Nodular Versus Intranodular Technique
Status: COMPLETED
Conditions: Hepatocellular Carcinomas
Interventions: PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the NeuMoDx SARS-CoV-2 Assay (COVID-19)
Status: RECRUITING
Conditions: SARS-CoV-2 Acute Respiratory Disease
Interventions: DIAGNOSTIC_TEST: NeuMoDx SARS-CoV-2 Assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancing Recovery in Coronary Heart Disease (ENRICHD) Patients
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Depression|Heart Diseases|Myocardial Infarction|Myocardial Ischemia
Interventions: BEHAVIORAL: social support
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Basiliximab Treating Interstitial Pneumonia of CADM
Status: UNKNOWN
Conditions: Lung; Disease, Interstitial, With Fibrosis|Dermatomyositis
Interventions: DRUG: Basiliximab|DRUG: Calcineurin Inhibitors|DRUG: Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic/Pharmacodynamic Genetic Variation Treatment Algorithm Versus Treatment As Usual for Management Of Depression
Status: COMPLETED
Conditions: Depression|Mood Disorder|Bipolar
Interventions: OTHER: AssureRx GeneSight genotyping results|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pasireotide Treatment for Neuroendocrine Tumor
Status: WITHDRAWN
Conditions: Gastro-enteropancreatic Neuroendocrine Tumor
Interventions: DRUG: Pasireotide|DRUG: Diazoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatoblastoma|Hepatocellular Carcinoma (HCC)|Liver Neoplasms|Metastatic Liver Cancer|Liver Cancer|HEMNOS
Interventions: DRUG: ET140203 T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury
Status: COMPLETED
Conditions: Brain Death
Interventions: BIOLOGICAL: BQ-A Peptide Extract|BIOLOGICAL: Mesenchymal Stem Cells|DEVICE: Transcranial Laser Therapy|DEVICE: Median Nerve Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DRUG: Semaglutide 1.0 mg|DRUG: Semaglutide 2.4 mg|DRUG: Placebo I (Semaglutide)|DRUG: Placebo II (Semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Line Versus Spot Ablation in Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: linear anatomically oriented ablations|PROCEDURE: focal electrophysiological oriented ablations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Pneumostem® Versus a Control Group for Treatment of BPD in Premature Infants
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: Pneumostem®|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of NEM® Brand Eggshell Membrane in Patients With Grade 2/3 Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DIETARY_SUPPLEMENT: NEM brand eggshell membrane|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HIV Screening Take-up: Evaluating Incentives and Opt-out Strategies
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Monetary Incentive|BEHAVIORAL: Questionnaire Timing|BEHAVIORAL: HIV Test Offering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Doppler Ultrasound Following Unicondylar Knee Replacement to Determine the Incidence of Postoperative DVT
Status: COMPLETED
Conditions: Number of Deep Venous Thrombosis (DVT)
Interventions: PROCEDURE: Doppler Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes|High Blood Pressure|Arthritis|Obesity
Interventions: DRUG: Metformin|DRUG: Val, Cel and Met XR Low|DRUG: Val, Cel and Met XR High
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin C Mesotherapy Versus Diode Laser for the Management of Physiologic Gingival Pigmentation
Status: COMPLETED
Conditions: Gingival Pigmentation
Interventions: OTHER: Vitamin C mesotherapy|RADIATION: Diode laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of ReHub in Patients Who Underwent Primary Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Rapid Recovery Rehabilitation Programme|DEVICE: ReHub
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Celecoxib in Treating Postmenopausal Women Who Are Undergoing Surgery for Invasive Breast Cancer
Status: COMPLETED
Conditions: Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: celecoxib|PROCEDURE: therapeutic conventional surgery|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systemic Therapy Sequenced Isolated PALND for mCRC
Status: RECRUITING
Conditions: Synchronous Isolated Para-aortic Lymph Node Metastasis|Colorectal Cancer
Interventions: PROCEDURE: Para-aortic lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nemonoxacin Malate Sodium Chloride Injection Administered by Intravenous Infusion
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nemonoxacin Malate Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections
Status: COMPLETED
Conditions: Mycoses
Interventions: DRUG: Voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of V710 Lyophilized Formulation (V710-004)
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Comparator: V710|BIOLOGICAL: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison 1 Plane-2 Injection and 2 Plane-2 Injection Ultrasound-guided Supraclavicular Brachial Plexus Block
Status: COMPLETED
Conditions: Radius Fractures
Interventions: DEVICE: stimuplex insulated needle|DRUG: lidocaine mixed with epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Clinical Study to Evaluate Efficacy and Safety of HSK21542 for Postoperative Analgesia of Subjects Undergoing Elective Laparoscopic Surgery Under General Anesthesia
Status: COMPLETED
Conditions: Postoperative Analgesia
Interventions: DRUG: HSK21542|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dermacyd PH_DESILSTY_FR (Lactic Acid) - Photo Evaluation - Stay on Frutal
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: LACTIC ACID(ND)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Additive Effects of QVAR to (Seretide) on Surrogate Markers of Airway Inflammation in Refractory Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: HFA-BDP|DRUG: Fluticasone|DRUG: Seretide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of PNF With Lower Leg Kinesio Taping in Chronic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: : lower leg kinesiotaping|OTHER: propriocepticve neuromuscular facilitation|OTHER: propriocepticve neuromuscular facilitation with lower leg kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multinational Study to Evaluate Tadalafil in Asian Men With Signs and Symptoms of Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Tadalafil|DRUG: Placebo|DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repurposing Anti-TNF for Treating Dupuytren's Disease
Status: COMPLETED
Conditions: Dupuytren's Disease
Interventions: DRUG: Adalimumab|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Skin Graft Versus Skin Graft and Stem Cell Application
Status: COMPLETED
Conditions: Accidental Wound|Heel Injury|Stem Cell Transplant
Interventions: BIOLOGICAL: mesenchymal stem cell application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Obstructive Sleep Apnoea Post Covid 19: Role of the Upper Airway Microbiome
Status: UNKNOWN
Conditions: Sleepiness|SARS-CoV2 Infection|Fatigue Syndrome, Chronic|Snoring
Interventions: DIAGNOSTIC_TEST: Nasal Lavage and Oral Wash
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lidocaine Spray Plus Oral Celecoxib for Pain Control During Hysterosalpingography
Status: COMPLETED
Conditions: IUCD Complication
Interventions: DRUG: celecoxib plus lidocaine|DRUG: Celecoxib|DRUG: lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Proprioceptive Treatment for Temporomandibular Dysfunction
Status: COMPLETED
Conditions: Facial Pain
Interventions: BEHAVIORAL: hyperbolid combined with tongue exercises on the palate|OTHER: hyperbolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dental Implants With a SLActive® vs. SLA® Surface
Status: ACTIVE_NOT_RECRUITING
Conditions: Partially Edentulous Patients
Interventions: DEVICE: SLActive® implant|DEVICE: SLA® implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Recurrence in Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea|Atrial Fibrillation
Interventions: DEVICE: Adaptive Servo-Ventilation|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes After Arthroscopic Tenotomy or Tenodesis of the Long Head of the Biceps
Status: UNKNOWN
Conditions: Arthroscopic Rotator Cuff
Interventions: PROCEDURE: tenotomy|PROCEDURE: tenodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Pharmacokinetics of MEDI9090 in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: MEDI9090|BIOLOGICAL: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Degree of Worry as a Predictor for Utilization of Acute Health Care
Status: COMPLETED
Conditions: Health Care Delivery|Telephone Hotlines|Patient Participation
Interventions: BEHAVIORAL: Awareness of degree of worry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Breast Cancer & Antiestrogenic Therapy & Brain
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Female|Healthy Female|Menopause|Anti-estrogenic Therapy
Interventions: DRUG: Tamoxifen|DRUG: Letrozole|DRUG: Letrozole + GnRH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mandibular Overdentures Retained by Mini Implants: a Clinical Trial Comparing Different Surgical and Loading Protocols
Status: COMPLETED
Conditions: Edentulous Mouth|Complete Edentulism
Interventions: PROCEDURE: Implant placement with flapped surgery|PROCEDURE: Implant placement with flapless surgery|PROCEDURE: Implant immediate loading|PROCEDURE: Implant delayed loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance and Safety Use of the Nanostructured Titanium Dental Implant "KONTACT N"
Status: COMPLETED
Conditions: Dental Implant|Dental Restoration|Edentulous Alveolar Ridge|Implant-supported Fixed Prosthesis
Interventions: DEVICE: dental implant (KONTACT N)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of the Association EGCG, Folic Acid and Vitamin B12 in Preventing the Persistence of HPV Infection.
Status: RECRUITING
Conditions: HPV Infection
Interventions: DIETARY_SUPPLEMENT: EGCG + folic acid + B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Distraction Technique to Improve Chest Burns With Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Burns Chest Left Lateral|Burns Chest Right Lateral|Acute Respiratory Distress Syndrome
Interventions: DEVICE: Virtual reality|PROCEDURE: Progressive muscle relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Topical Anesthesia Alone Versus Combined With Intracameral LIdocaine 1%
Status: COMPLETED
Conditions: Other Iris and Ciliary Body Disorders
Interventions: DRUG: topical anesthesia|DRUG: topical anesthesia plus intracameral lidocaine 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: General Anesthesia vs Local Anesthesia for Endovascular Treatment in Patients With Unruptured Intracranial Aneurysm Using Flow Diverter
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: OTHER: Different anesthesia methods, namely local anesthesia and general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Anastrozole vs Exemestane/Letrozole
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Anastrozole|DRUG: Exemestane/Letrozole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Lamina Cribrosa (LC) Changes in the Eyes After Laser-Assisted in Situ Keratomileusis (LASIK)
Status: COMPLETED
Conditions: The Lamina Cribrosa and Optic Nerve Head Changes
Interventions: DEVICE: Exposed to the high pressure during the surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Long-Term PF-06651600 for the Treatment of Alopecia Areata
Status: ACTIVE_NOT_RECRUITING
Conditions: Alopecia Areata
Interventions: DRUG: PF-06651600|BIOLOGICAL: Tetanus and diphtheria toxoids and acellular pertussis (Tdap) vaccine|BIOLOGICAL: Meningococcal (groups A, C, W-135 and Y [ACWY]) oligosaccharide diphtheria CRM197 conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Sertraline in Patients Who Have Had Inadequate Response to Escitalopram
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: sertraline (Zoloft)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia
Status: UNKNOWN
Conditions: Corneal Ectasia
Interventions: PROCEDURE: riboflavin-induced collagen cross-linking treatment|DEVICE: Riboflavin-UVA induced collagen cross-linking treatment for corneal ectasia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clofarabine, Idarubicin, and Cytarabine (CIA) Versus Fludarabine, Idarubicin, and Cytarabine (FLAI) in Acute Myelogenous Leukemia (AML) and High-Risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Clofarabine|DRUG: Idarubicin|DRUG: Cytarabine|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Kinesio Taping Able to Influence the Electrical Activity of Muscles in Patients With Low Back Pain?
Status: UNKNOWN
Conditions: Chronic Low Back Pain
Interventions: OTHER: Kinesio Taping|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SI-B001 Combined With Chemotherapy in the Treatment of EGFR/ALK WT Recurrent or Metastatic NSCLC.
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: SI-B001|DRUG: AP or TP|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FCR or APL in LRTI - A Single Surgeon Randomized Controlled Trial
Status: WITHDRAWN
Conditions: Osteoarthritis
Interventions: PROCEDURE: Flexor carpi radialis|PROCEDURE: Abductor pollicis longus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab With Hormonal and Radiotherapy for High-Risk Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: bevacizumab, bicalutamide and goserelin|PROCEDURE: intensity modulated radiation therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Physiological Stability Variability and Robustness of NIS4
Status: RECRUITING
Conditions: Evaluate the Physiological Stability of NIS4 Biomarker Between the Fed and Fasting State in Patients With the Target Condition (NAFLD)
Interventions: DIAGNOSTIC_TEST: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Outcome Between (ERACS) Versus Traditional Methods in Elective CS
Status: NOT_YET_RECRUITING
Conditions: ERAS
Interventions: OTHER: ERAS community recommendation|OTHER: Traditional postoperative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Perfusion and Diffusion Mechanism of Intervertebral Disc-Significance With Age, Degeneration, Posture and Stress Loading.
Status: COMPLETED
Conditions: Spinal Cord Injury, Degenerative Spinal Disease.
Interventions: PROCEDURE: imaging diagnostics
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Progression From Impaired Fasting Glucose to Diabetes Mellitus Among Chinese
Status: COMPLETED
Conditions: Progression From Impaired Fasting Glucose to Diabetes Mellitus
Interventions: DIAGNOSTIC_TEST: Oral Glucose Tolerance Test|DIAGNOSTIC_TEST: HbA1c
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Zinc Deficiency Treatment in Celiac Disease: Supplementation Versus Diet
Status: RECRUITING
Conditions: Celiac Disease|Nutrient Deficiency
Interventions: DIETARY_SUPPLEMENT: Zinc Supplementation|OTHER: Zn-Optimized Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guangzhou Nutrition and Health Study (GNHS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Osteoporosis|Diabetes Mellitus, Type 2|Metabolic Syndrome|Obesity|Hypertension|Non-Alcoholic Fatty Liver Disease|Chronic Kidney Diseases|Cancer|Death|Nutrition Disorders|Sarcopenia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: VR Mind and VR Mind+ Intervention
Status: COMPLETED
Conditions: Social Phobia
Interventions: BEHAVIORAL: Virtual Reality Exposure Therapy VR Mind+|BEHAVIORAL: Virtual Reality Exposure Therapy VR Mind|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Post COVID-19 Fatigue
Status: NOT_YET_RECRUITING
Conditions: Acupuncture|Post COVID-19 Condition|Fatigue
Interventions: DEVICE: Acupuncture|DEVICE: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Implementing an Infant Driven Feeding Program on Oral Feeding and Growth Outcomes of Medically Fragile Infants in the Neonatal ICU (NICU)
Status: COMPLETED
Conditions: Oral Feeding Outcomes|Growth|Length of NICU Stay
Interventions: OTHER: SOFFI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MR Guided Focused Ultrasound Surgery in the Treatment of Pain From Bone Tumors w/ the ExAblate 2000 Strappable System
Status: COMPLETED
Conditions: Bone Metastases
Interventions: DEVICE: Exablate 2000 strappable system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High-Tc Susceptometer to Monitor Transfusional Iron Overload
Status: COMPLETED
Conditions: Transfusional Iron Overload|Thalassemia Major|Sickle Cell Disease|Myelodysplastic Syndromes|Aplastic Anemia
Interventions: DEVICE: Hepatic biomagnetic susceptibility measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Effect of a Novel Web-based Intervention to Increase HIV Testing in Men Who Have Sex With Men
Status: COMPLETED
Conditions: HIV Testing
Interventions: BEHAVIORAL: Online HIV testing motivational videos and messages sent via mobile-phone text messaging, e-mail or instant messaging|BEHAVIORAL: Standard online message with an invitation for free HIV testing similar in content to other Peruvian websites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Evaluate the Safety and Performance of Spectranetics Laser w/Adjunct PTA and Gore Viabahn Endoprosthesis for Treatment of SFA Instent Restenosis
Status: TERMINATED
Conditions: Restenosis
Interventions: DEVICE: Spectranetics Laser with adjunct PTA and Gore VIABAHN Endoprosthesis with Heparin Bioactive Surface
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Icotinib Plus Chemotherapy Versus Icotinib Alone as First-line Treatment in Stage IIIB/IV Lung Adenocarcinoma
Status: UNKNOWN
Conditions: EGFR Positive Non-small Cell Lung Cancer|Adenocarcinoma
Interventions: DRUG: Sequential Icotinib Plus Chemotherapy|DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Upfront Premedication For Reduction of Microvascular Obstruction and No-reflow in Treating ST-segment Elevation Myocardial Infarction
Status: NOT_YET_RECRUITING
Conditions: STEMI|Large Thrombus Burden|No-Reflow Phenomenon
Interventions: OTHER: Upfront preparation of microcirculation to minimize risks of no-reflow and reperfusion injury
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Tolerance and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-Inflammatory Hyperpigmentation)
Status: NOT_YET_RECRUITING
Conditions: Solar Lentigo|Senile Lentigo|Post Inflammatory Hyperpigmentation
Interventions: DEVICE: Condition 1 : Prototypes (816-v1) every weeks|DEVICE: Condition 2 : Prototypes (816-v1) every two weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Digital Weight Loss Treatment for Rural Individuals
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Core|BEHAVIORAL: Facilitated Weekly Group Sessions|BEHAVIORAL: Counselor Crafted Feedback|BEHAVIORAL: Individual Coaching Calls|BEHAVIORAL: Pre-Scripted Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Determinants of 6-minute Walk Test and Its Correlation With Quality of Life
Status: COMPLETED
Conditions: Aged
Interventions: OTHER: 6 Minute Walk Test|OTHER: EQ-5D Survey|OTHER: Short Physical Performance Battery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Minocycline|DRUG: Placebo (Tetracycline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Repetition Improves Precision and Trueness of Digital Intraoral Scans
Status: COMPLETED
Conditions: Tooth Diseases
Interventions: OTHER: impression data from reference scanner|DEVICE: iTero|DEVICE: Trios
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Evaluating the Safety and Pharmacokinetics of Aldurazyme® (Laronidase) in MPS I Patients Less Than 5 Years Old
Status: COMPLETED
Conditions: Mucopolysaccharidosis I|Hurler Syndrome|Hurler-Scheie Syndrome|Scheie Syndrome
Interventions: BIOLOGICAL: Aldurazyme (Recombinant Human Alpha-L-Iduronidase)|BIOLOGICAL: Aldurazyme (Recombinant Human Alpha-L-Iduronidase)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioembolization and Ipilimumab in Treating Patients With Uveal Melanoma With Liver Metastases
Status: TERMINATED
Conditions: Ciliary Body and Choroid Melanoma, Medium/Large Size|Ciliary Body and Choroid Melanoma, Small Size|Extraocular Extension Melanoma|Iris Melanoma|Liver Metastases|Metastatic Intraocular Melanoma|Recurrent Intraocular Melanoma|Stage IV Intraocular Melanoma
Interventions: BIOLOGICAL: ipilimumab|RADIATION: yttrium Y 90 glass microspheres|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GV 1001 Immunotherapy in Patients With Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: GV 1001 Telomerase peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telehealth Treatment of Veterans With Alcohol Misuse at Risk for Cardiovascular Disease
Status: RECRUITING
Conditions: Alcohol Misuse|Hypertension|Elevated Cardiovascular Risk
Interventions: BEHAVIORAL: Alcohol and CVD Management and Engagement through Telehealth and mHealth (ACME-TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HPV 16-positive and/or HPV 18-positive Recurrent and/or For Patients With Metastatic Head and Neck Cancer to Evaluate GX-188E DNA Vaccination, GX-I7 and Nivolumab Combination Therapy
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: nivolumab-GX-188E-GX-I7
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison the Effect of Uterine Closure Technique Difference on Uterine Niche After Caesarean Delivery.
Status: UNKNOWN
Conditions: Uterine Niche|Closure; Incomplete, Uterus
Interventions: OTHER: Suture technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Exercises in Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: Schroth Exercises|OTHER: Core stabilization Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Amnion Membrane Allograft and Early Return of Erectile Function After Radical Prostatectomy
Status: RECRUITING
Conditions: Prostate Cancer|Erectile Dysfunction Following Radical Prostatectomy
Interventions: BIOLOGICAL: BioDFence G3 Placental Tissue Membrane|PROCEDURE: Robot-Assisted Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia
Status: COMPLETED
Conditions: Leishmaniasis, Cutaneous|Leishmania Braziliensis Complex|Leishmaniasis, American|Leishmaniasis; American, Cutaneous
Interventions: DRUG: Paromomycin Sulfate|DRUG: Pentamidine Isethionate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Recovery After Orthopaedic Trauma: Cognitive-Behavioral Based Physical Therapy (CBPT)
Status: COMPLETED
Conditions: Lower Extremity Injury
Interventions: OTHER: CBPT|OTHER: Education Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Tumor, Solid
Interventions: DRUG: Durvalumab and Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Pioglitazone for HIV-Metabolic Syndromes
Status: COMPLETED
Conditions: HIV Infections|Type 2 Diabetes|Obesity|HIV|AIDS|Cardiovascular Disease|Lipodystrophy
Interventions: DRUG: Pioglitazone|BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Cranial Electrotherapy Stimulation[CES] for Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DEVICE: Cranial electrotherapy stimulation (CES)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Nuedexta in Subjects With ALS
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: Nuedexta|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib Plus Sintilimab in Advanced Gastric Cancer Refractory to at Least Two Previous Chemotherapy Regimens
Status: UNKNOWN
Conditions: Advanced Metastatic Gastric Cancer
Interventions: DRUG: Apatinib Mesylate|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenously Administered Tamiflu (Oseltamivir) in Patients Over 13 Years of Age With Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Oseltamivir IV|DRUG: Oseltamivir Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of LIZTOX in Subjects With Benign Masseteric Hypertrophy
Status: RECRUITING
Conditions: Benign Masseteric Hypertrophy
Interventions: DRUG: Botulinum toxin type A|DRUG: normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: to Compare the Effectiveness of Thulium Fiber Laser and Holmium YAG Laser for Ureteroscopic Lithotripsy
Status: COMPLETED
Conditions: Ureteric Stone
Interventions: PROCEDURE: Ureteroscopic lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
Status: UNKNOWN
Conditions: Polyneuropathy
Interventions: PROCEDURE: Muscular electrostimulation and percutaneus muscular biopsy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a New Laparoscopic Technique for Parastomal Hernia Repair With Mesh
Status: WITHDRAWN
Conditions: Hernia|Abdominal Hernia
Interventions: PROCEDURE: Laparoscopic parastomal hernia repair with mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gabapentin on Orthopedic Pain
Status: TERMINATED
Conditions: Degenerative Arthritis and Postoperative Pain
Interventions: DRUG: Placebo|DRUG: Gapabentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Patients With Advanced or Recurrent Mycosis Fungoides
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: CHOP regimen|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Omission of Breast Surgery for Breast Cancer Patients With pCR on MRI and Vacuum-assisted Biopsy After NST (OPTIMIST)
Status: RECRUITING
Conditions: Breast Cancer Invasive
Interventions: PROCEDURE: Breast surgery omission
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct Peroral Cholangioscopy by Using an Ultra-slim Upper Endoscope
Status: COMPLETED
Conditions: Bile Duct Stricture|Choledocholithiasis
Interventions: DEVICE: Direct peroral cholangioscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Disitamab Vedotin Combined With Fruquintinib for mCRC With HER2 Expression
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2|Colorectal Cancer
Interventions: DRUG: Disitamab Vedotin Combined With Fruquintinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Biomarkers Using Tissue Samples From Older Patients With Diffuse Large B-Cell Lymphoma Treated With Combination Chemotherapy With or Without Rituximab on Clinical Trial ECOG-E4494
Status: COMPLETED
Conditions: Lymphoma
Interventions: OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Estradiol/Norethindrone Acetate|DRUG: Placebo for Elagolix|DRUG: Elagolix|DRUG: Placebo for E2/NETA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of LMP1- and LMP2- Specific Cytotoxic T-Lymphocytes (CTL)
Status: WITHDRAWN
Conditions: NASOPHARYNGEAL CARCINOMA
Interventions: GENETIC: genetically modified CTLs in combo with CD45 antibodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ridaforolimus (MK-8669) in Combination With Dalotuzumab (MK-0646) Compared to Standard of Care Treatment in Estrogen Receptor Positive Breast Cancer Patients (MK-8669-041 AM3)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: ridaforolimus + dalotuzumab|DRUG: exemestane|DRUG: ridaforolimus|DRUG: dalotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of ADV6209 for Premedication in Pediatric Anesthesia
Status: COMPLETED
Conditions: Preanesthetic Medication
Interventions: DRUG: ADV6209 (=gamma-cyclodextrin-Midazolam)|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sargramostim in Reducing Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplantation for Hematologic Cancer or Aplastic Anemia
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Lymphoma|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intravenous Palonosetron With Radiotherapy and Concomitant Temozolomide
Status: COMPLETED
Conditions: Malignant Glioma
Interventions: DRUG: Palonosetron (PALO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial for Non-inferiority and Safety of Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in Patients With Hematologic Malignancies Who Require Prophylactic Hepatitis B Antiviral Treatment
Status: NOT_YET_RECRUITING
Conditions: Patients With Malignant Blood Disease Requiring Hepatitis B Antiviral Medication
Interventions: DRUG: Vemlidy|DRUG: Virreal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety, Engraftment, and Efficacy of VC-01 in Subjects With T1 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes
Interventions: COMBINATION_PRODUCT: VC-01 Combination Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Oxymetazoline Gel on Anal Pressure and Incontinence in Spinal Cord Injury Patients
Status: COMPLETED
Conditions: Fecal Incontinence|Spinal Cord Injury
Interventions: DRUG: Oxymetazoline gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prematurity as Predictor of Children's Cardiovascular-renal Health
Status: COMPLETED
Conditions: Endothelial Dysfunction|Sublingual Capillary Glycocalyx and Density|Visual Disturbances and Blindness|Ventricular Dysfunction, Left|Renal Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treat-to-target Strategy in Ankylosing Spondylitis Using Etanercept and Conventional Synthetic DMARDs
Status: UNKNOWN
Conditions: Ankylosing Spondylitis|Spondyloarthritis
Interventions: DRUG: Methotrexate|DRUG: Sulfasalazine|DRUG: Hydroxychloroquine|DRUG: Etanercept (50mg per week, for 4 weeks)|DRUG: Etanercept (50mg per week, for 2 weeks)|DRUG: Etanercept (50mg per week)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT