pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: FLT PET in Measuring Treatment Response in Patients With Newly Diagnosed Estrogen Receptor-Positive, HER2-Negative Stage I-III Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor Positive|HER2/Neu Negative|Male Breast Carcinoma|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: DRUG: Fluorothymidine F-18|PROCEDURE: Positron Emission Tomography|OTHER: Laboratory Biomarker Analysis|DRUG: Run-in (short pre-surgery course) of endocrine-targeted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Care Bundle in Preventing Pressure Ulcers Caused by Medical Devices in the Pediatric Intensive Care Unit
Status: UNKNOWN
Conditions: Pressure Ulcer|Nursing Caries|Device Induced Injury
Interventions: OTHER: care bundle application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Safety and Tolerability of Human CD19-CD22 Targeted T Cells Injection for Subjects With R/R B-ALL.
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Human CD19-CD22 Targeted T Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Calisthenic Exercise Training in Patients With Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: Calisthenic exercise training with telerehabilitation|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community Based Management of Severe Malnutrition in Tribal Area of Melghat- Cluster Randomized Control Field Trial
Status: COMPLETED
Conditions: Child Nutrition Disorders|Malnutrition
Interventions: OTHER: MAHAN RUTF & MAHAN Vit-Min mix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth
Status: COMPLETED
Conditions: White Spot Lesion
Interventions: OTHER: Self Assembling Peptide P11-4 (CURODONTTM REPAIR) + Fluoride varnish (DURAFLOR|OTHER: Fluoride varnish (DURAFLOR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhalation/Nasal Corticosteroids and Prevalence of Hypothalamic-pituitary-adrenal (HPA) Axis Suppression in Human Immunodeficiency Virus (HIV)-Patients
Status: UNKNOWN
Conditions: Adrenal Insufficiency
Interventions: OTHER: ACTH stimulation test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity or Both?
Status: RECRUITING
Conditions: Dental Implant Failed|Implant Complication|Implant Site Infection|Implant Site Reaction
Interventions: DIAGNOSTIC_TEST: Clinical Examination|PROCEDURE: Peri-implant crevicular fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Temporary Application of Abdominal Jackson-Pratt Drain to Reduce Pain After Laparoscopic Surgery in Gynecology
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: DEVICE: abdominal Jackson-Pratt drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Pericapsular Nerve Block in Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Hip Osteoarthritis|Hip Arthropathy
Interventions: OTHER: Pericapsular Nerve Block|OTHER: Fascia Iliaca Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers
Status: COMPLETED
Conditions: Acute Bacterial Corneal Ulcers|Bacterial Keratitis
Interventions: DRUG: Gatifloxacin 0.3% ophthalmic solution|DRUG: Ciprofloxacin 0.3% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Eye Injections of Bevacizumab for Lowering Risk of Scar Tissue in the Retina and Repeated Retinal Detachment.
Status: COMPLETED
Conditions: Retinal Detachment|Vitreoretinopathy Proliferative
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Quetiapine XR (extended release)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: FLX475 Combined With Pembrolizumab in Patients With Advanced or Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: FLX475|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Guanfacine on Delirium in Critically Ill Patients
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: adaptatiVe Endovascular Strategy to the CloT MRI in Large Intracranial Vessel Occlusion
Status: COMPLETED
Conditions: Intracranial Thrombosis
Interventions: PROCEDURE: combined EMBOTRAP II or III and Contact Aspiration|PROCEDURE: Contact Aspiration alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies to Reduce Transmission of Antimicrobial Resistant Bacteria in Intensive Care Units (STAR*ICU) Trial
Status: COMPLETED
Conditions: Bacterial Diseases
Interventions: PROCEDURE: Intensive Control Strategy|BEHAVIORAL: Standard Control Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exercise and Diet Counseling Program in Improving Quality of Life in Stage I-III Breast Cancer Survivors
Status: COMPLETED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Cancer Survivor|Obesity|Overweight|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: OTHER: Aerobic Exercise|OTHER: Exercise Counseling|OTHER: Nutritional Assessment|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Therapeutic Effects of Plyometric Exercises in Children With Type 1 Diabetis
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: OTHER: regular care|OTHER: plyometric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bridging Trial Comparing Sugammadex (Org 25969) at 1-2 Post-Tetanic Count (PTC) in Japanese Participants. Part A (P05957)
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Adding Lung Protective Strategies to Existing Enhanced Recovery After Surgery (ERAS) Protocols and Its Effects on Improving Post-Operative Lung Function
Status: COMPLETED
Conditions: Colorectal Surgery|Hepatobiliary Surgery
Interventions: PROCEDURE: Standard Enhanced Recovery After Surgery (ERAS) Protocol|PROCEDURE: ERAS and 5 Lung Protective Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long Term Study of Ambrisentan in Pulmonary Arterial Hypertension Subjects Having Completed AMB-320 (NCT00423748) or AMB-321 (NCT00423202)
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Half-normal Saline in Atrial Fibrillation Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Half-normal saline|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Autologous Gamma Delta T Cells to Target Prostate Stem Cell Antigen in mCRPC
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: BIOLOGICAL: MSGV1-PSCA-8T28Z|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Long-term Safety of Oral Lacosamide in Subjects With Partial-onset Seizures
Status: COMPLETED
Conditions: Partial Epilepsies|Partial Onset Seizures
Interventions: DRUG: lacosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre-Exposure Prophylaxis of HIV-1 Infection
Interventions: DRUG: F/TAF|DRUG: F/TDF|DRUG: F/TAF Placebo|DRUG: F/TDF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Dual Yellow Laser Versus Stabilized Kilnman Preparation in the Treatment of Melasma
Status: COMPLETED
Conditions: Melasma
Interventions: DEVICE: Dual yellow Laser|DRUG: Stabilized kilnman trio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of PEG-rhG-CSF in Patients With Hemophagocytic Syndrome
Status: UNKNOWN
Conditions: Hemophagocytic Syndrome
Interventions: DRUG: PEG-rhG-CSF|DRUG: rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Determine the Efficacy, Safety and Tolerability of Denosumab (AMG 162) in the Treatment of Postmenopausal Women With Low Bone Mineral Density
Status: COMPLETED
Conditions: Low Bone Mineral Density
Interventions: DRUG: Placebo|DRUG: Denosumab|DRUG: Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Toric Intraocular Lens to Neutralize Keratometric Astigmatism
Status: TERMINATED
Conditions: Cataract|Astigmatism
Interventions: PROCEDURE: Acrysof Toric one-piece intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of CJM112 in Patients With Inadequately Controlled Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CJM112|OTHER: Placebo to CJM112
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Cognitive Impairment
Interventions: OTHER: Acupuncture|OTHER: Sham Acupuncture|DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abuse-Focused Cognitive Behavioral Therapy for Children Who Have Been Physically Abused
Status: COMPLETED
Conditions: Child Abuse
Interventions: BEHAVIORAL: Abused-focused cognitive behavioral therapy (AF-CBT)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)
Status: COMPLETED
Conditions: Autism Spectrum Disorder (ASD)|Autism|Autistic Disorder|Asperger's Disorder|Asperger's|Pediatric Autism|Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)
Interventions: DRUG: Memantine Hydrochloride (HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PVI Using Cryoablation Alone in Paroxysmal AF Patients Converted From Persistent AF With Dofetilide
Status: WITHDRAWN
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: PROCEDURE: Ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability, and Pharmacokinetics of HSK21542 in Healthy Volunteers
Status: COMPLETED
Conditions: Postoperative Pain|Chronic Pain
Interventions: DRUG: HSK21542|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Menopausal Gonadotropin (HMG) vs Recombinant Follicle Stimulating Hormone (rFSH) in Gonadotropin Releasing Hormone (GnRH) Antagonist Cycles
Status: COMPLETED
Conditions: Ovarian Stimulation
Interventions: DRUG: Human Menopausal Gonadotropin (HMG) & - Recombinant Follicle Stimulating Hormone (r-FSH)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Study of Efficacy and Safety of Investigational Treatment in Patients With Nail Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Nail Psoriasis|Plaque Psoriasis
Interventions: DRUG: AT193
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Being Responsible for Ourselves HIV Risk Reduction for Black MSM
Status: COMPLETED
Conditions: Human Immunodeficiency Virus Infection (HIV)|Sexually Transmitted Disease (STD)
Interventions: BEHAVIORAL: BRO HIV Risk Reduction Intervention|BEHAVIORAL: Health Promotion Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Effect of MK0966 (Rofecoxib) on the Recurrence of Colorectal Adenomas (0966-122)
Status: COMPLETED
Conditions: Colorectal Adenoma
Interventions: DRUG: MK0966; Rofecoxib / Duration of Treatment: 156 weeks|DRUG: Placebo/ Duration of Treatment: 156 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Abraxane in CIMP-High Colorectal and Small Bowel Adenocarcinomas
Status: COMPLETED
Conditions: Colorectal Cancer|Cancer of Gastrointestinal Tract
Interventions: DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of KAE609 in Reducing Asexual & Sexual Blood-stage P.Falciparum Infection & Infectivity to Mosquitos
Status: TERMINATED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: KAE609|DRUG: Piperaquine Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion
Status: COMPLETED
Conditions: Pleural Effusion, Malignant
Interventions: PROCEDURE: pleurodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin in Reducing the Need for Pain Medication in Patients With Bladder Cancer Undergoing Radical Cystectomy
Status: COMPLETED
Conditions: Bladder Carcinoma
Interventions: DRUG: Gabapentin|OTHER: Placebo|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Two Strategies in the Monitoring of Exudative ARMD on the Visual Acuity (by OCT B Scan or OCT Angiography)
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DEVICE: OCT B-scans|DEVICE: OCT angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Esketamine|DRUG: Placebo|DRUG: Duloxetine (Oral Antidepressant)|DRUG: Escitalopram (Oral Antidepressant)|DRUG: Sertraline (Oral Antidepressant)|DRUG: Venlafaxine Extended Release (XR) (New Antidepressant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electroconvulsive Therapy Amplitude Titration
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Allogeneic PBSCT to Treat Hematologic Malignancies and Hematopoietic Failure States
Status: COMPLETED
Conditions: Hematologic Neoplasms|Multiple Myeloma|Anemia, Aplastic|Hemoglobinuria, Paroxysmal|Myelofibrosis
Interventions: DRUG: busulfan, and melphalan, and alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of the Skinstylus Sterilock Microneedling System for the Treatment of Facial Wrinkles
Status: COMPLETED
Conditions: Subjects Displaying Facial Ageing
Interventions: DEVICE: Skinstylus microneedling device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromotor Prosthetic to Treat Stroke-Related Paresis
Status: UNKNOWN
Conditions: Stroke, Complication|Stroke|Stroke Sequelae|Hemiparesis|Arm Paralysis
Interventions: DEVICE: Cortimo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comprehensive Genetic Assessment, Risk and Education in a Mammography Pilot
Status: COMPLETED
Conditions: Women Age 35+ Qualifies if >15% Lifetime Risk of Breast Cancer as Defined by IBIS Version 8
Interventions: GENETIC: Genetic Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face
Status: COMPLETED
Conditions: Neoplastic Syndrome
Interventions: DRUG: tazarotene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial to Test the "Coordinated Care for Health Promotion and Activities in Parkinson's Disease" Intervention in the VA
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Coordinated care management for Parkinson's disease|OTHER: Educational handout
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy Study of Ultrasonic Coagulation Device and Bipolar Energy Sealing System
Status: UNKNOWN
Conditions: Thyroid Cancer
Interventions: DEVICE: Ultrasonic coagulation device (Harmonic ACE® scalpel)|DEVICE: bipolar energy sealing system (LigaSure Precise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF)
Status: TERMINATED
Conditions: Hyponatremia|Acute Decompensated Heart Failure
Interventions: DRUG: conivaptan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DAAOI-2 add-on Treatment for Treatment-resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: DAAOI-2|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Pediatric Emergence Delirium in Sevoflurane-rocuronium Anesthesia
Status: COMPLETED
Conditions: Emergence Delirium
Interventions: DRUG: Sugammadex Injection [Bridion]|DRUG: Neostigmine+Glycopyrronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Evaluation of MRI Biomarkers in Pancreatic Ductal Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Adenocarcinoma
Interventions: OTHER: MRIs with and without intravenous contrast (up to 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prophylaxis Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Antihemophilic factor, recombinant, manufactured protein-free|DRUG: Antihemophilic factor, recombinant, manufactured protein-free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CYP3A Genetic Polymorphisms on the Pharmacokinetics of Atorvastatin
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy and Safety of Flurbiprofen Chip Versus Chlorhexidine Chip (Periochip®) in Therapy of Adult Chronic Periodontitis
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Flurbiprofen|DRUG: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of XS-02 Capsules in Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor|Ovarian Cancer|Breast Cancer|Endometrial Cancer
Interventions: OTHER: XS-02 capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous At Home Administration of Trastuzumab (Herceptin) in Participants With Human Epidermal Growth Factor Receptor 2-positive (HER2+) Early Breast Cancer (eBC)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Optimization in the Postoperative Treatment in Head and Neck--surgical Patients.
Status: UNKNOWN
Conditions: Hyperglycemia Steroid-induced|Hyperglycemia Stress|Surgery--Complications
Interventions: OTHER: Prevention of hyperglycemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High-Intensity Interval Training Early After Left Ventricular Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: OTHER: HIIT|OTHER: MICE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epidemiology of Incidents and Accidents in Sport. Influence of Moisture.
Status: UNKNOWN
Conditions: Fractures|Sprain|Stress Fractures|Aches|Tendinitis
Interventions: DIETARY_SUPPLEMENT: eau minérale d'Aix-Les-Bains|DIETARY_SUPPLEMENT: tap water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer
Status: COMPLETED
Conditions: Melanoma|Merkel Cell Carcinoma|Squamous Cell Carcinoma|Penile Carcinoma|Urethral Carcinoma|Extramammary Paget's Disease|Scrotal Carcinoma|Anal Cancer|Vulvar Cancer|Skin Cancer|Lymphadenopathy
Interventions: PROCEDURE: Videoscopic procedure|PROCEDURE: Open, traditional approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study of the Feasibility of Ambulatory Appendicectomy for Acute Appendicitis (Based on Data From the PMSI French National Hospital Information System) in the Adults Hospitalized Between December 2013 and December 2014
Status: WITHDRAWN
Conditions: Appendicitis
Interventions: OTHER: database.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-Invasive Bioelectronic Analytics
Status: ENROLLING_BY_INVITATION
Conditions: Autonomic Dysfunction|Autonomic Imbalance|Autonomic Nervous System Diseases|Vagus Nerve Autonomic Disorder
Interventions: OTHER: Standing-Squatting-Standing Test|OTHER: Deep Breathing Test|OTHER: Cold Pressor Test|OTHER: Cold Face Test|OTHER: Valsalva Maneuver|DEVICE: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study on Predictive Biomarkers of Neoadjuvant Chemoradiotherapy for Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasm Malignant Carcinoma|Chemoradiotherapy|Neoadjuvant Therapy|Predictive Biomarkers|Adenocarcinoma
Interventions: RADIATION: Radiation|DRUG: Capecitabine-Irinotecan Combination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subdermal Implant-bioabsorbable Gestrinone Pellet for Endometriosis Pelvic Pain Treatment
Status: RECRUITING
Conditions: Deep Endometriosis|Pelvic Pain
Interventions: DRUG: Gestrinone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gamification and Medication Adherence (GAME Adherence)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension and Hyperlipidemia
Interventions: BEHAVIORAL: HTN and Medication Adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Training Programme to Reduce Stress
Status: COMPLETED
Conditions: Autism Spectrum Disorder (ASD)
Interventions: BEHAVIORAL: Training to Reduce Stress in Mothers of Children with (ASD)|OTHER: Nothing (treatment as usual)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety and Protective Effect Study of GSK Biologicals' Human Papillomavirus (Types 16, 18) Vaccine, Adsorbed (GSK580299) in Healthy Female Subjects From the HPV-039 Study
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: BIOLOGICAL: HPV (Types 16, 18) Vaccine, Adsorbed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reclaim Deep Brain Stimulation Clinical Study for Treatment-Resistant Depression
Status: COMPLETED
Conditions: Depression
Interventions: DEVICE: Reclaim™ DBS System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IHAT Absorption Kinetics
Status: COMPLETED
Conditions: Iron-deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: IHAT|DIETARY_SUPPLEMENT: Ferrous sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cell Therapy for Diabetic Foot Ulcer
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer Associated With Type II Diabetes Mellitus|Wound Heal
Interventions: COMBINATION_PRODUCT: InbioDerm + C plus advanced healing|PROCEDURE: Advanced healing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Addition of IL-2 to Pegylated Interferon Alpha 2a and Ribavirin in HIV/HCV Coinfected Patients
Status: COMPLETED
Conditions: HIV Infections|Chronic Hepatitis C
Interventions: DRUG: Interleukin 2|DRUG: pegylated interferon alpha 2a|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Efficacy and Safety of Lenalidomide, Subcutaneous Bortezomib and Dexamethasone Therapy for Newly Diagnosed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Lenalidomide|DRUG: Dexamethasone|PROCEDURE: Stem Cell Mobilization|PROCEDURE: Autologous Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between CellFX and Electrodessication in Sebaceous Hyperplasia (SH) Lesions
Status: COMPLETED
Conditions: Skin Lesion|Skin Abnormalities|Sebaceous Hyperplasia
Interventions: DEVICE: CellFX System|DEVICE: Intralesional Electrodesiccation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing Volar, Dorsal, and Custom Thermoplastic Splinting in the Treatment of Acute Mallet Finger
Status: COMPLETED
Conditions: Mallet Finger
Interventions: DEVICE: Volar aluminum splint|DEVICE: Dorsal aluminum splint|DEVICE: Custom thermoplastic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Novel Exhalational Delivery System With Fluticasone (EDS-FLU) on Eustachian Tube Dysfunction (ETD)
Status: RECRUITING
Conditions: Eustachian Tube Dysfunction
Interventions: DRUG: Fluticasone Propionate 93 MCG/1 ACTUATION Nasal Spray|OTHER: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of X4P-001 in Participants With Advanced Renal Cell Carcinoma
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma
Interventions: DRUG: X4P-001|DRUG: axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pravastatin for Prevention of Preeclampsia
Status: ACTIVE_NOT_RECRUITING
Conditions: Preeclampsia
Interventions: DRUG: Pravastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Humanized Monoclonal Antibody 3F8 (Hu3F8) With Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in the Treatment of Recurrent Osteosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Osteosarcoma
Interventions: BIOLOGICAL: humanized anti-GD2 antibody|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Polyphenol Rich Diet on Vascular and Platelet Function
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Two portions of fruit and vegetables per day (excluding berries and dark chocolate)|OTHER: Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impacts of Oral Irrigation in Orthodontic Patients
Status: COMPLETED
Conditions: Oral Hygiene|Orthodontics|Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: GCF (gingival crevicular fluid) collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement
Status: COMPLETED
Conditions: Pathological Gambling
Interventions: DRUG: Haloperidol|DRUG: Fluphenazine|DRUG: Dexedrine|DRUG: Placebo|BEHAVIORAL: Slot Machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Paracetamol Absorption Technique as a Method for Measuring Gastric Tube Outlet
Status: COMPLETED
Conditions: Esophageal and/or Cardia Cancer|Esophagectomy|Gastric Pull-up Reconstruction
Interventions: OTHER: Measuring emptying rate from the gastric tube
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Comparison of Efficacy Between Electromagnetic Stimulation Therapy and Electromagnetic Stimulation Therapy With Extracorporeal Biofeedback
Status: COMPLETED
Conditions: Urinary Stress Incontinence
Interventions: DEVICE: Electromagnetic stimulation therapy (BIOCON-2000)|DEVICE: Electromagnetic stimulation therapy with biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Evaluate Outpatient Blinatumomab in Subjects With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL)
Status: RECRUITING
Conditions: B-precursor Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab|DEVICE: Current Wearable Heatlth Monitoring System (CWHMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neramexane for Tinnitus
Status: COMPLETED
Conditions: Tinnitus
Interventions: DRUG: Neramexane|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-Ascending Dose Study of BIIB054 in Healthy Participants and Early Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Healthy
Interventions: DRUG: BIIB054|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety Pilot Study to Investigate Iberogast N's Efficacy in Mild to Moderate Colitis Ulcerosa Patients
Status: TERMINATED
Conditions: Colitis, Ulcerative
Interventions: DRUG: STW5-II (Iberogast N, BAY98-7410)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metaverse-Based Healthy Life Program for Youth
Status: NOT_YET_RECRUITING
Conditions: Health Risk Behaviors|Healthy Lifestyle|Non Communicable Diseases|Health-Related Behavior|Healthy Eating Index|Healthy Nutrition|Physical Inactivity|Stress, Emotional
Interventions: BEHAVIORAL: MetaHealth Group|BEHAVIORAL: MobileHealth Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Periodontal Therapy in Chronic Periodontitis Patients With and Without Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Chronic Periodontitis
Interventions: PROCEDURE: Periodontal examination|PROCEDURE: GCF sampling|PROCEDURE: phase I therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Breast Carcinoma in Situ|Breast Cancer Female
Interventions: OTHER: Control Arm ACSM Guidelines|OTHER: Experimental Arm 6-12-25 repetitions per set
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of SNP of GnRH Receptor Genes in IVF Patients
Status: UNKNOWN
Conditions: Infertility, Female
Interventions: DRUG: GnRH-a|DRUG: Human Menopausal Gonadotropins
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The Effect of Acupoint Massotherapy on Relieving Chemotherapy-induced Myelosupression
Status: UNKNOWN
Conditions: Cancer, Breast|Acupressure|Hematopoiesis
Interventions: DEVICE: The Electric vibrating massager,SAMPO®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Electro-acupuncture at Zusanli, Qihai, and Guanyuan Acupoints Regulate Immune Function in Patients With Sepsis
Status: COMPLETED
Conditions: Sepsis|Immune Dysfunction
Interventions: DEVICE: electro-acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality
Status: RECRUITING
Conditions: Rhinosinusitis Chronic|Sinus Cancer|Sinus Polyp|Encephalocele
Interventions: DRUG: Tranexamic acid injection|DRUG: Total Intravenous Anesthesia|DRUG: Inhalational isoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Leucovorin and Fluorouracil Compared With Observation in Treating Patients With Colorectal Cancer That Has Been Surgically Removed
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: L-leucovorin|DRUG: fluorouracil|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Modes of Isotonic Exercises for Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Standard physical Therapy|PROCEDURE: Closed Kinetic Chain|PROCEDURE: Open Kinetic Chain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine Follow-up for Bariatric Surgery Patients: What Do Patients Prefer
Status: TERMINATED
Conditions: Obesity
Interventions: OTHER: Telemedicine 30-day post-op visit|OTHER: In-Person 30-day post-op visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colon Adenocarcinoma|Rectal Adenocarcinoma|Stage III Colorectal Cancer AJCC v7|Stage IIIA Colorectal Cancer AJCC v7|Stage IIIB Colorectal Cancer AJCC v7|Stage IIIC Colorectal Cancer AJCC v7|Stage IV Colorectal Cancer AJCC v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7
Interventions: DRUG: Clobetasol Propionate|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinematic Analysis of a PS, FB Primary Total Knee Arthroplasty (ATTUNE Knee System) Using Dynamic RSA
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Primary Total Knee Arthroplasty (ATTUNE Knee System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cardiovascular Effects of Apelin In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Apelin 1mg subcutaneous|DRUG: Apelin 1mg intravenous|DRUG: Apelin 5mg subcutaneous|DRUG: Apelin 5mg intravenous|DRUG: Apelin 10 mg subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Clinical Investigation on the Blood Oxygenation at the Optic Nerve Head in Fabry Patients
Status: COMPLETED
Conditions: Fabry Disease
Interventions: PROCEDURE: Contrast sensitivity measurement|PROCEDURE: Slit Lamp assessment and intra-ocular pressure measurement|PROCEDURE: Visual field testing|PROCEDURE: Oxygen flow at the optic nerve head measurement|DRUG: Tropicamide|DEVICE: OSOME
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals
Status: RECRUITING
Conditions: Effect of iv Administration of GIP and Alanine
Interventions: OTHER: Placebo (saline)|DRUG: GIP|DRUG: Alanine|DRUG: GIP + alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK)
Status: COMPLETED
Conditions: ALK-activated Tumors
Interventions: DRUG: Ceritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PT217 in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)
Status: RECRUITING
Conditions: Small Cell Lung Cancer (SCLC)|Large Cell Neuroendocrine Cancer (LCNEC)|Neuroendocrine Prostate Cancer (NEPC)|Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC)
Interventions: DRUG: PT217
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Status: RECRUITING
Conditions: Bipolar Depression
Interventions: DRUG: Escitalopram|DRUG: Sertraline|DRUG: Venlafaxine|DRUG: Lithium|DRUG: Valproate acid|DRUG: Quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q10 in Juvenile Idiopathic Arthritis Patients
Status: RECRUITING
Conditions: Juvenile Idiopathic Arthritis
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|OTHER: Placebo|DRUG: Standard Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Massage for Children With Autism Spectrum Disorder
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: PROCEDURE: Pediatric massage therapy|PROCEDURE: Usual care|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Telintra® in Deletion 5q Myelodysplastic Syndrome
Status: TERMINATED
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: ezatiostat hydrochloride (Telintra®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT