pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Ischemia-Reperfusion Injury
Interventions: DRUG: dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Smoking Cessation in Hispanic Construction Workers
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Nicorette Gum|DRUG: Nicoderm CQ|OTHER: Smoking Quitline Referral|BEHAVIORAL: Behavioral Smoking Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]
Status: RECRUITING
Conditions: Aging
Interventions: DRUG: rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Cervical and Endometrial Cancer
Status: RECRUITING
Conditions: Cervical Cancer|Endometrial Cancer|Advanced Cancer
Interventions: DRUG: Recombinant oncolytic herpes simplex virus type Ⅰ (R130)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Exercise, Recovery Drinks and Appetite
Status: COMPLETED
Conditions: Active Population
Interventions: DIETARY_SUPPLEMENT: Protein drink|DIETARY_SUPPLEMENT: Carbohydrate drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)
Status: TERMINATED
Conditions: Pemphigus Vulgaris|Pemphigus Foliaceus
Interventions: BIOLOGICAL: efgartigimod PH20 SC|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Autonomic Function in Women With Microvascular Coronary Dysfunction
Status: ACTIVE_NOT_RECRUITING
Conditions: Microvascular Coronary Dysfunction
Interventions: BEHAVIORAL: Mental Stress Testing|OTHER: Peripheral Arterial Tonometry (PAT) Testing|OTHER: Heart Rate Variability (HRV)|OTHER: RESPeRATE Breathing Trial|PROCEDURE: SPECT cardiac scan with 123I-mIBG and Myoview
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of NGM621 in Participants With Geographic Atrophy
Status: COMPLETED
Conditions: Geographic Atrophy
Interventions: BIOLOGICAL: NGM621|BIOLOGICAL: NGM621|BIOLOGICAL: NGM621|BIOLOGICAL: NGM621
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observation of Patients With Metastatic Colorectal Cancer Starting Chemotherapy Combined With Bevacizumab (Avastin)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: OTHER: Observational Chemotherapy|DRUG: Concomitant Bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravitreal Aflibercept in Wet Age Related Macular Degeneration Patients With an Incomplete Response to Routine Ranibizumab Injections
Status: TERMINATED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ezetimibe on the Absorption of Oxidized Cholesterol
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements
Status: COMPLETED
Conditions: HIV Infections|HIV Wasting Syndrome
Interventions: DIETARY_SUPPLEMENT: Multivitamin and mineral supplements|DIETARY_SUPPLEMENT: Peptamen|DIETARY_SUPPLEMENT: NuBasics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Pharmacokinetic Study of MT-3995 in Subjects With Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: MT-3995-Low|DRUG: MT-3995-High|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurodevelopment at 5.5 Years of Age in Children Who Received Infant Formula With Enriched Protein Fractions
Status: COMPLETED
Conditions: Cognitive Ability, General
Interventions: DIETARY_SUPPLEMENT: Enriched Protein Fractions|DIETARY_SUPPLEMENT: Protein Fraction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiofrquency Ablation Combined With Cytokine-induced Killer Cells for Colorectal Cancer Liver Metastases
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Radiofrequency ablation|BIOLOGICAL: Cytokine-induced killer cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a New Emulsion in Dry Eye Patients on Tear Layer Aberrometry, Contrast Sensitivity, and Reading Ability
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Optive|DRUG: Soothe|DRUG: New Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Urinary Claudin-2, Caveolin-1, and EGF as Diagnostic Biomarkers of Necrotizing Enterocolitis in Preterm Neonates
Status: UNKNOWN
Conditions: Enterocolitis, Necrotizing|Infant, Premature
Interventions: DIAGNOSTIC_TEST: Urinary Claudin-2|DIAGNOSTIC_TEST: Urinary Caveolin-1|DIAGNOSTIC_TEST: Urinary EGF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Effects Of Dialysate Flow Rate And Membrane Packing On The Performance Of Dialyzers Used For Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Renal Disease
Interventions: DEVICE: Polyflux HD-C4 Big|DEVICE: HD-C4 Small|DEVICE: Optiflux 160NR|DEVICE: Optiflux 200NR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation in Hypertension
Status: COMPLETED
Conditions: Hypertension, Resistant to Conventional Therapy|Renal Denervation
Interventions: PROCEDURE: renal denervation and optimized medication regimen|PROCEDURE: optimized medication regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant FDC With Melatonin or Metformin for Locally Advanced Breast Cancer.
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: metformin|DRUG: Fluoruracil|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of PXL770 Versus Placebo After 12 Weeks of Treatment in Patients With NAFLD
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver
Interventions: DRUG: PXL770|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Program Intensive Habilitation (PIH) for Young Children With Early Brain Damage
Status: RECRUITING
Conditions: Brain Injuries|Cerebral Palsy|Motor Skills Disorders|Empowerment|Parent-Child Relations|Parenting
Interventions: OTHER: Program Intensified Habilitation|OTHER: Habilitation as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Kinesio Taping Method for Knee Osteoarthritis.
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Taping application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Thirty Million Words Project: A Feasibility Trial
Status: COMPLETED
Conditions: Parental Language Behaviors
Interventions: BEHAVIORAL: LENA Linguistic Feedback Reports|BEHAVIORAL: Home Visiting Educational Session|BEHAVIORAL: Childhood Nutrition Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of RO5479599 Alone or in Combination With Cetuximab or Erlotinib in Participants With Metastatic and/or Locally Advanced Malignant Human Epidermal Growth Factor Receptor (HER3) Expressing Solid Tumors of Epithelial Cell Origin
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: RO5479599|DRUG: Cetuximab|DRUG: Erlotinib|DRUG: zirconium-89-labeled RO5479599
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Second-Line Treatments for Anovulatory Infertility in PCOS Patients
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Infertility|Anovulation
Interventions: DRUG: Metformin plus clomiphene citrate|PROCEDURE: Laparoscopic ovarian drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
Status: RECRUITING
Conditions: Kidney Stones|Nephrolithiasis
Interventions: BEHAVIORAL: Empiric Therapy: Diet|DRUG: Empiric Therapy: Drug|BEHAVIORAL: Selective Therapy: Diet|DRUG: Selective Therapy: Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Project to Distribute Water Filters and Cookstoves in Western Rwanda
Status: COMPLETED
Conditions: Faecal Contamination of Household Drinking Water (Environmental Outcome)
Interventions: BEHAVIORAL: Household drinking water filters and cookstoves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TMC114-C214: Trial of TMC114 Administered With Low Dose Ritonavir (RTV) in HIV-1 Infected Treatment Experienced Patients
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: LPV/rtv|DRUG: TMC114/rtv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The BARCODE 1 Study (Full Study): The Use of Genetic Profiling to Guide Prostate Cancer Targeted Screening.
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: GENETIC: Genetic SNP profiling|OTHER: Prostate cancer screening|PROCEDURE: MRI Scan|PROCEDURE: Prostate biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples
Status: TERMINATED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: GENETIC: microarray analysis|OTHER: flow cytometry|PROCEDURE: biopsy|PROCEDURE: colposcopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Better Living With Non-memory-led Dementia
Status: COMPLETED
Conditions: Primary Progressive Aphasia|Frontotemporal Dementia|Alzheimer Disease
Interventions: BEHAVIORAL: Better living with non-memory led dementia course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of NSAIDs After a Rotator Cuff Repair Surgery.
Status: WITHDRAWN
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Rotator cuff repair|DRUG: Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole|DRUG: Hydrocodone/Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Needle Modified With Supercritical Fluid
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DEVICE: SCF-N-treated needles|DEVICE: Untreated needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Nitrate Intake in Vegetarians and Omnivores
Status: COMPLETED
Conditions: Blood Pressure
Interventions: OTHER: Placebo mouthwash|OTHER: Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Growth and Tolerance of Healthy Term Infants to a New Infant Formula
Status: TERMINATED
Conditions: Healthy Term Infants
Interventions: OTHER: Milk based infant formula powder|OTHER: Investigational Infant Formula #1|OTHER: Investigational Infant Formula #2|OTHER: Human Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open, Dose-escalation Clinical Study of Chimeric Exosomal Tumor Vaccines for Recurrent or Metastatic Bladder Cancer
Status: UNKNOWN
Conditions: Recurrent or Metastatic Bladder Cancer
Interventions: BIOLOGICAL: Chimeric exosomal tumor vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Macular Degeneration|Macular Edema|Branch Retinal Vein Occlusion
Interventions: DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Nab-Paclitaxel|PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Intraoperative ETCO2 Levels and Postoperative Pain and Nausea-Vomiting
Status: RECRUITING
Conditions: Pain, Postoperative|Nausea, Postoperative|Vomiting, Postoperative
Interventions: OTHER: ETCO2 levels|OTHER: Patients with high ETCO2 levels
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of the Cardio First Angle Device on CPR Outcomes
Status: COMPLETED
Conditions: Cardiopulmonary Arrest
Interventions: DEVICE: Compression with Feedback|OTHER: Standard chest compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I/IIa Study of BR790 in Combination With Tislelizumab in Adult Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: BR790+Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Ventriculo-peritoneal Shunt in Subarachnoid Patients With External Ventricular Drainage
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage|Ventriculo-Peritoneal Shunt Infection|Hydrocephalus
Interventions: PROCEDURE: External ventricular drainage (EVD) conversion into ventriculo-peritoneal shunt (VPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
Status: UNKNOWN
Conditions: Keratoconus|Ectasia
Interventions: DRUG: Ricrolin+|DRUG: Epi-Off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intralesional HiLow Hyaluronic Acid in the Treatment of Peyronie's Disease (PD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Peyronie Disease
Interventions: DEVICE: Pre-filled syringe of HiLow Hyaluronic Acid Sodium Salt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Group-comparison P-III Study With Zolpidem MR Using Placebo and Nitrazepam in Insomnia Patients
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders
Interventions: DRUG: zolpidem MR|DRUG: nitrazepam|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Long Term Clarithromycin for Prevention of Exacerbations in Non-cystic Fibrosis Bronchiectasis in Asian Populations
Status: UNKNOWN
Conditions: Bronchiectasis Adult
Interventions: DRUG: Clarithromycin|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Metastatic Head-and-neck Squamous-cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Ficlatuzumab|BIOLOGICAL: Cetuximab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Immunogenicity & Safety of GSK Biologicals' HPV Vaccine in Female Subjects Aged 10-14 Years
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: HPV-16/18 L1/AS04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults
Status: RECRUITING
Conditions: Obesity|Insufficient Sleep
Interventions: BEHAVIORAL: sleep extension intervention|BEHAVIORAL: contact control intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Efficacy, Safety, and Tolerability of KAN-101 in People With Celiac Disease
Status: RECRUITING
Conditions: Celiac Disease|Coeliac Disease
Interventions: DRUG: KAN-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Foot Muscles Training and Foot Orthosis on the Medial Arch in Flatfoot Subjects
Status: COMPLETED
Conditions: Flexible Flatfoot
Interventions: DEVICE: foot insole|OTHER: short foot exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (CALM-2)
Status: RECRUITING
Conditions: Refractory Chronic Cough
Interventions: DRUG: BLU-5937|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery
Status: WITHDRAWN
Conditions: Pelvic Pain|Endometriosis|Pelvic Prolapse
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Ondansetron to Attenuate the Hypotensive, Bradycardic Response to Spinal Anesthesia in Healthy Parturients
Status: COMPLETED
Conditions: Hypotension|Pregnancy
Interventions: DRUG: ondansetron|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Routine in Thoracic Outlet Syndrome
Status: RECRUITING
Conditions: Thoracic Outlet Syndrome
Interventions: DIAGNOSTIC_TEST: Ultrasound|DIAGNOSTIC_TEST: angiography|DIAGNOSTIC_TEST: questionnaires|DIAGNOSTIC_TEST: Transcutaneous oximetry|DIAGNOSTIC_TEST: plethysmography|DIAGNOSTIC_TEST: Electromyogram|DIAGNOSTIC_TEST: Standard X-Ray
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A New Quantitative Fecal Immunochemical Test in Detecting Colorectal Advanced Adenoma
Status: COMPLETED
Conditions: Colorectal Adenoma|Colorectal Neoplasm|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: The new qFIT and colonoscopy with pathological examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of 'URSA SOFT CAP. (UDCA-003)' in Fatigue Patients With Liver Dysfunction
Status: COMPLETED
Conditions: Fatigue
Interventions: DRUG: Ursodeoxycholic acid, thiamine, riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts
Status: COMPLETED
Conditions: Bone Cyst Aneurysmal|Pathological Fracture|Recurrent Disease|Refractory Tumor
Interventions: DRUG: Denosumab (Xgeva)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phamacokinetics and Safety Profiles of DA-1229_01 2.5/500mg in Healthy Subjects at Fed State
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: DA-1229_01 2.5/500mg (Before)|DRUG: DA-1229_01 2.5/500mg (After)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: DRUG: pramlintide acetate|DRUG: sibutramine|DRUG: phentermine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Consumption of Alcohol-free Beers With Different Carbohydrates Composition on Postprandial Metabolic Response
Status: COMPLETED
Conditions: Healthy Diet|Postprandial Hyperglycemia
Interventions: OTHER: Sub-study 1|OTHER: Sub-study 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Asthma Clinical Research Network (ACRN)
Status: WITHDRAWN
Conditions: Asthma|Lung Diseases
Interventions: DRUG: Albuterol|DRUG: Colchicine|DRUG: Adrenal Cortex Hormones|DRUG: Adrenergic-Beta Agonists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Rater-blinded RCT to Compare Effectiveness of EMDR vs TAU in Patients With First Episode Psychosis and History of Psychological Trauma
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychotic Episode|Psychological Trauma
Interventions: BEHAVIORAL: Eye movement desensitization and reprocessing therapy|DRUG: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Glucoside- and Rutinoside-rich Material in Chemotherapy-induced Peripheral Neuropathy and Related Symptoms
Status: UNKNOWN
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DIETARY_SUPPLEMENT: Mulberry juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia
Status: COMPLETED
Conditions: Body Temperature Changes|Anesthesia
Interventions: DRUG: Midazolam|DRUG: Propofol|DRUG: Standard|DEVICE: SpotOn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding
Status: COMPLETED
Conditions: HIV Infections|Herpes Simplex
Interventions: DRUG: valacyclovir|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Intervention for Breast Cancer Survivors With Diabetes
Status: COMPLETED
Conditions: Diabetes|Breast Cancer
Interventions: BEHAVIORAL: Integrated Intervention for Breast Cancer Survivors with Diabetes|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in Treating Non-Smokers With Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: paclitaxel|DRUG: carboplatin|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AK112 in the Treatment of Advanced Gynecological Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Gynecologic Cancer|Cancer Metastatic|Ovarian Neoplasms|Cervical Neoplasm|Endometrial Neoplasms
Interventions: DRUG: AK112
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Preliminary Randomized Study of Tianjiu (Auto-moxibustion) Effects in Patients With Intradialytic Hypotension
Status: UNKNOWN
Conditions: Intradialytic Hypotension
Interventions: OTHER: Tianjiu|OTHER: Placebo (non-Tianjiu)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Supraclavicular Brachial Plexus Block Using Ropivacaine Alone and With Dexmedetomidine
Status: COMPLETED
Conditions: Brachial Plexus Anesthesia
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine with Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study of a Contact Force Catheter for Pulmonary Vein Antrum Isolation
Status: COMPLETED
Conditions: Atrial Fibrillation|Burden of Atrial Fibrillation
Interventions: PROCEDURE: Contact Force during ablation|OTHER: Standard ablation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Hepatitis B Vaccine Model for HIV Vaccine Trials in Drug Users
Status: COMPLETED
Conditions: Hepatitis B Infection|Hepatitis C Infection|HIV Infection
Interventions: BIOLOGICAL: hepatitis B vaccine 3 dose schedule (0,1,2 month)|BEHAVIORAL: HBV Vaccination Self-Efficacy Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic or Recovered Hepatitis B|Chronic or Recovered Hepatitis C|Chronic or Recovered Hepatitis D|NAFLD|NASH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endometrial Tissues and Mononuclear Cells Receptivity in Pathogenesis of Endometrial Proliferative Processes
Status: COMPLETED
Conditions: Endometrial Hyperplasia Without Atypia|Endometrial Hyperplasia With Atypia|Endometrial Cancer|Peripheral Blood Mononuclear Cells|Postmenopause|Estrogen Receptor|Progesterone Receptor
Interventions: DIAGNOSTIC_TEST: endometrial tissue and peripheral blood mononuclear cells receptivity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Colchicine on the Pharmacokinetic Profile of LC350189 in Healthy Aldults.
Status: COMPLETED
Conditions: Gout|Hyperuricemia
Interventions: DRUG: Xanthine Oxidase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seroquel Switching Study: Feasibility of Switching Any Antipsychotic Treatment to Seroquel in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Seroquel SR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia
Status: COMPLETED
Conditions: Post Herpetic Neuralgia
Interventions: DRUG: NXN-462|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE
Status: COMPLETED
Conditions: Pulmonary Embolism|Pulmonary Hypertension|Thromboembolism|Right Ventricular Dysfunction
Interventions: DRUG: Alteplase|DEVICE: EKOS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kinematics After Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: DePuy ATTUNE total knee arthroplasty system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: Masitinib (4.5)|DRUG: Riluzole|DRUG: Placebo|DRUG: Masitinib (3.0)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Can Methylnaltrexone Safely Treat Opioid Related Constipation in the Emergency Department?
Status: WITHDRAWN
Conditions: Colonic Inertia
Interventions: DRUG: Methylnaltrexone Bromide (MNTX)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Probiotic Supplement in IBS-D
Status: RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea|Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Therapy in Advanced Ovarian Cancer With Avastin
Status: TERMINATED
Conditions: Cancer, Ovarian
Interventions: DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress Disorders, Traumatic|Stress Disorders, Traumatic, Acute|Depressive Symptoms|Anxiety|Substance Use|Aggression|Coping Skills|Impulsive Behavior|Housing Problems|Recidivism|Stress|Occupational Stress|Psychological Distress
Interventions: BEHAVIORAL: Resiliency in Stressful Experiences (RISE) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Demonstrate Bioequivalence Between 3 x 2-mg Tablets of Perampanel and a Single 6-mg Tablet of Perampanel in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: perampanel|DRUG: perampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EPA for Metastasis Trial 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Metastasis|Colon Cancer
Interventions: DRUG: Icosapent Ethyl|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of NMN (Nicotinamide Mononucleotide) on Polycystic Ovary Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: NMN intervention|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Positron Emission Tomography (PET) Study With [18F]AZD4694 and [11C]AZD2184, Candidate PET Ligands for Aβ Amyloid
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: radioligand [18F]AZD4694|DRUG: radioligand [11C]AZD2184
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gene Therapy for Transfusion Dependent Beta-thalassemia
Status: UNKNOWN
Conditions: Beta-Thalassemia
Interventions: GENETIC: Autologous hematopoietic stem cells genetically modified with GLOBE lentiviral vector encoding for the human beta-globin gene
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study of QY101 Ointment in Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: QY101 ointment or vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Balloon Pulmonary Angioplasty for Patients With Chronic Thromboembolic Pulmonary Hypertension
Status: UNKNOWN
Conditions: Chronic Thromboembolic Pulmonary Hypertension
Interventions: PROCEDURE: Ballon pulmonary angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Formulations of Tablets Ramipril/Hydrochlorothiazide 10 mg/25 mg in Healthy Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Ramipril/Hydrochlorothiazide tablet 10 mg/25 mg|DRUG: Tritace® Plus tablet 10 mg/25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics of Intranasal Dexmedetomidine in Healthy Subjects
Status: UNKNOWN
Conditions: Sedation
Interventions: DRUG: Intranasal Dexmedetomidine|DRUG: Intravenous Dexmedetomidine|DRUG: Intranasal Placebo|DRUG: Intravenous Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Treatment of Thoracic & Cardiovascular Disease With Biological Therapy: ClinicalCellRegistry.Com
Status: UNKNOWN
Conditions: Cardiovascular System Diseases (& [Cardiac])
Interventions: BIOLOGICAL: cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tandospirone, Amlodipine and Their Combination in Adults With Hypertension and Anxiety
Status: UNKNOWN
Conditions: Hypertension|Anxiety
Interventions: DRUG: Tandospirone + Amlodipine|DRUG: Tandospirone placebo + Amlodipine|DRUG: Tandospirone + Amlodipine placebo|DRUG: Tandospirone placebo + Amlodipine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Cost of State Quitline Policies
Status: COMPLETED
Conditions: Smoking Cessation|Tobacco Use Cessation|Cost-effectiveness
Interventions: BEHAVIORAL: Multi-session telephone counseling|DRUG: NRT patches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vascular Effects of Sitagliptin in Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Placebo|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effectiveness of High-Intensity Laser Therapy in Patients With Cervical Radiculopathy:
Status: COMPLETED
Conditions: Radiculopathy|Musculoskeletal Diseases|Cervical Pain|Cervical Radicular Pain|Cervical Disc Disease
Interventions: DEVICE: High-intensity laser therapy (HILT)|DEVICE: Sham high-intensity laser therapy (Sham HILT)|OTHER: Therapeutic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Effects of Estradiol on Neural and Molecular Response to Reward
Status: RECRUITING
Conditions: Depression|Psychosis|Anhedonia
Interventions: DRUG: Transdermal Estradiol|DRUG: Micronized Progesterone|DRUG: Matching Placebo Patch|DRUG: Raclopride C11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Concordance of Five Times Sit To Stand Results Between a Physical Consultation and a Teleconsultation
Status: RECRUITING
Conditions: Rehabilitation|Elderly Person|Teleconsultation
Interventions: OTHER: Physical consultation|OTHER: Teleconsultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Second-line Therapy for Patients With Progressive Poorly Differentiated Extra-pulmonary Neuroendocrine Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Oncology|Neuroendocrine Carcinoma
Interventions: DRUG: Liposomal Irinotecan|DRUG: Fluorouracil|DRUG: Folinic Acid|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-term Safety and Efficacy of ATB200/AT2221 in Adult Subjects With LOPD
Status: ACTIVE_NOT_RECRUITING
Conditions: Pompe Disease (Late-onset)
Interventions: DRUG: AT2221|BIOLOGICAL: ATB200
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Tolerability, Safety, and Pharmacokinetics of CRA-024781 in Cancer Patients
Status: COMPLETED
Conditions: Hematologic Neoplasms|Neoplasms
Interventions: DRUG: CRA-24781
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatigue in Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Sjogren's Syndrome|Fatigue|Pain Syndrome|Depression|Anxiety|Fibromyalgia
Interventions: DIAGNOSTIC_TEST: FACT-F questionnaire|DIAGNOSTIC_TEST: Beck Depression Inventory|DIAGNOSTIC_TEST: Beck Anxiety Inventory|DIAGNOSTIC_TEST: Insomnia severity index.|OTHER: ESSPRI|OTHER: ESSDAI|OTHER: Pain Detect Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: PROCEDURE: Preoperative hepatic and regional arterial chemotherapy using oxaliplatin, MMC and FUDR|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery
Status: NOT_YET_RECRUITING
Conditions: Constipation|Surgical Procedure, Unspecified|Prolapse; Female
Interventions: DRUG: Polyethylene Glycol 3350
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of "Opening Doors to Recovery" for Persons With Serious Mental Illnesses
Status: COMPLETED
Conditions: Mental Disorders, Severe|Schizophrenia and Related Disorders|Bipolar Disorder|Depressive Disorder
Interventions: BEHAVIORAL: Opening Doors to Recovery|BEHAVIORAL: Case Management|BEHAVIORAL: Intensive Case Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Into Airways Disease Case Finding and Management
Status: COMPLETED
Conditions: COPD|Asthma
Interventions: PROCEDURE: Case finding Clinic|PROCEDURE: At Risk Case Clinics|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma
Status: COMPLETED
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: Mitotane|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of a Full Face Mask Seal for the Treatment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Toffee full face mask with 'Improved Seal'|DEVICE: Toffee full face mask with 'Normal Seal'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Interstitial Lung Disease
Interventions: GENETIC: Research Testing Performed (Laboratory)|DIAGNOSTIC_TEST: Information Collected as Standard of Care|OTHER: Research Testing Performed
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of ONO-2506 in Patients With Acute Ischemic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: ONO-2506|DRUG: ONO-2506|DRUG: ONO-2506
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dasatinib Combination Therapy With the Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML)
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Dasatinib|DRUG: BMS-833923
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of Pembrolizumab to the Standard of Care Chemotherapy in Patient With SCCOHT
Status: RECRUITING
Conditions: Small Cell Ovarian Carcinoma
Interventions: DRUG: Pembrolizumab 25 MG/ML [Keytruda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Determine the Best Feeding Practice in Preterm Infants on Non-invasive Ventilation.
Status: RECRUITING
Conditions: Prematurity; Extreme|Feeding Patterns|Ventilator Lung; Newborn
Interventions: OTHER: Continuous Feeds|OTHER: Intermittent Bolus Feeds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ASD (Autism Spectrum Disorder) Telehealth for Distress Related to COVID-19
Status: COMPLETED
Conditions: Psychological Distress|Stress, Psychological|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Emotional Support Plan|BEHAVIORAL: Daily Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION