pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mechanical Bowel Preparation Before Laparoscopic Hysterectomy and Laparoscopic Sacrocolpopexy: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Laparoscopic Hysterectomy and/or Laparoscopic Sacrocolpopexy
Interventions: DRUG: Fleet Enema (sodium biphosphate and sodium phosphate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Liposome-encapsulated Daunorubicin-Cytarabine, Fludarabine Phosphate, Cytarabine, and Filgrastim in Treating Younger Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia Post Cytotoxic Therapy|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|BIOLOGICAL: Filgrastim|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone vs. Dexmedetomidine for Popliteal Nerve Block in Pain Management After Pediatric Ankle and Foot Surgery
Status: RECRUITING
Conditions: Foot Injuries and Disorders|Ankle Injuries and Disorders
Interventions: DRUG: 0.9%sodium chloride|DRUG: Dexamethasone|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ImmunoBoost: The Lymphatic Osteopathic Manipulative Treatment Protocol Study
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: PROCEDURE: Osteopathic Manipulative Treatment (OMT)|OTHER: Sham Light Touch|OTHER: Exercise Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Hypnosis on Adherence to Continuous Positive Airway Pressure.
Status: NOT_YET_RECRUITING
Conditions: Apnea Syndrome|Apnea, Obstructive
Interventions: OTHER: medical hypnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Nurse-led Coaching Programme With Telemonitoring in Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Telemonitoring|Hospitalizations|Feasibility|Mentoring
Interventions: COMBINATION_PRODUCT: Nurse-led telephone coaching intervention with home telemonitoring of vital signs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D and Grass Pollen Specific Immunotherapy
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: DRUG: Cholecalciferol|OTHER: middle-chain fatty acids (carrier)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Histamine and Bone Pain Association in Participants With Breast Cancer Metastatic in the Bone
Status: ACTIVE_NOT_RECRUITING
Conditions: Bone Pain|Breast Carcinoma Metastatic in the Bone
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study: Gene Expression Profiling of Immune Response to HBV Vaccination in Healthy Volunteers
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Hepatitis B Vaccine (Recombinant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zevalin for Patients With Incomplete Response to Chemo Prior to Autologous Stem Cell Transplant for Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: indium-111-ibritumomab tiuxetan|DRUG: 90Y Zevalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Detemir With NPH Insulin in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin NPH|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cord Blood and Human Placental Derived Stem Cells in Neonates With Severe Hypoxic-Ischemic Encephalopathy
Status: WITHDRAWN
Conditions: Severe Hypoxic-ischemic Encephalopathy
Interventions: DRUG: HPDSC|DRUG: Cord blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photon Therapy Face Mask on Dermatitis Post Head and Neck Radiotherapy
Status: COMPLETED
Conditions: Head and Neck Cancers - Nasopharyngeal
Interventions: DEVICE: photon therapy face mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors
Status: RECRUITING
Conditions: Be Diagnosed With Cancer and Have Completed Systemic Therapy
Interventions: DRUG: Bupropion Hydrochloride Controlled-release|OTHER: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy and Safety of Amlodipine Besylate and Candesartan Cilexetil in Essential Hypertension Patient Who Are Not Adequately Controlled With Amlodipine Besylate Monotherapy
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Amlodipine 5mg|DRUG: Amlodipine 5mg, Candesartan cilexetil 16mg|DRUG: Amlodipine 10mg, Candesartan cilexetil 16mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thulium Laser Versus Bipolar Enucleation of the Prostate
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: Thulium laser enucleation of the prostate|PROCEDURE: Bipolar enucleation of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Daratumumab in Combination With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared to CyBorD Alone in Newly Diagnosed Systemic Amyloid Light-chain (AL) Amyloidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyloidosis
Interventions: DRUG: Cyclophosphamide|DRUG: Bortezomib|DRUG: Dexamethasone, 40 mg|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Efficacy on Lipids in Tinnitus Patients With Obesity
Status: UNKNOWN
Conditions: Tinnitus, Subjective|Obesity|Lipids
Interventions: OTHER: true acupuncture|OTHER: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Bioavailability and Food Effect of Selumetinib (AZD6244) in Healthy Male Participants
Status: COMPLETED
Conditions: Neurofibromatosis Type 1 (NF1)-Related Plexiform Neurofibromas (PNs)|Healthy Participants
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Breathing Retraining in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: respiratory biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Study the Influence of Ultrasound Guidance on the Complications of Central Catheter
Status: UNKNOWN
Conditions: Central Venous Catheters|Obesity
Interventions: PROCEDURE: Central Venous Catheter Insertion|DEVICE: Ultrasound guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium Diet
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Aliskiren plus placebo|DRUG: Aliskiren|DRUG: Aliskiren plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Versus Low Dose Nitroglycerin in Acute Pulmonary Edema
Status: ENROLLING_BY_INVITATION
Conditions: Pulmonary Edema
Interventions: DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate Control
Status: UNKNOWN
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: DRUG: Metoprolol|DRUG: Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Approved Drugs in Patients With Osteoarthritis (0966-220)(COMPLETED)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: MK0966, rofecoxib|DRUG: Comparator: celecoxib, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease
Status: COMPLETED
Conditions: Genetic Risk for Alzheimer's Disease
Interventions: DRUG: donepezil HCL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Eluxadoline (Viberzi®) 100 mg Twice Daily on Diarrhea-Associated Fecal Incontinence
Status: WITHDRAWN
Conditions: Fecal Incontinence|Accidental Bowel Leakage|Anal Incontinence|Diarrhea|Urge Incontinence
Interventions: DRUG: Eluxadoline 100 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Time-restricted Eating on the Outcomes Associated With Polycystic Ovary Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: BEHAVIORAL: Time-restricted eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Convolutional Neural Network Model to Detect Coronavirus Disease 2019 (COVID-19) Pneumonia in Chest Radiographs
Status: COMPLETED
Conditions: COVID-19 (Coronavirus Disease 2019)|COVID-19 Pneumonia
Interventions: OTHER: Categorization of chest xrays images
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomised, Double Blind, Placebo Controlled, 4 Period, Incomplete Block, Crossover Study Assessing the Dose-response Curve of Fluticasone Propionate in an Antigen Challenge Chamber
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial|Allergic Rhinitis
Interventions: DRUG: Fluticasone propionate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FACBC Positron Emission Tomography/Computed Tomography(PET/CT) Used in the Diagnosis of Primary Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancers
Interventions: DRUG: anti [18F]FACBC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oregovomab With or Without Cyclophosphamide in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Responded to Second-Line Chemotherapy
Status: WITHDRAWN
Conditions: Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma|Recurrent Ovarian Carcinoma|Stage III Ovarian Cancer|Stage IV Ovarian Cancer
Interventions: DRUG: Cyclophosphamide|PROCEDURE: Laboratory Biomarker Analysis|BIOLOGICAL: Oregovomab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-dose and Multiple-dose X842 Phase 1 Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Single ascending dose of X842|DRUG: Multiple ascending dose of X842|OTHER: Food Effect
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Sitting and Moderate Exercise on Plasma Insulin and Glucose Responses to an Oral Glucose Tolerance Test
Status: UNKNOWN
Conditions: Sedentary Behavior|Insulin Sensitivity|Sedentary Lifestyle
Interventions: BEHAVIORAL: SIT|BEHAVIORAL: ACTIVE|BEHAVIORAL: EX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Forodesine in Patients With Relapsed B-cell Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: B-cell Chronic Lymphocytic Leukemia
Interventions: DRUG: Forodesine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab Versus Pembrolizumab for Advanced-stage Non-Small-Cell Lung Cancer
Status: UNKNOWN
Conditions: Nsclc
Interventions: DRUG: Sintilimab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Response Effects of Quillivant XR in Children With ADHD and Autism: A Pilot Study
Status: COMPLETED
Conditions: ADHD|Autism
Interventions: DRUG: Very Low Dose Quillivant XR|DRUG: Low Dose Quillivant XR|DRUG: Moderate Dose Quillivant XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantitative Detection of CEA mRNA in the Smog and Tissue Exudate Whole Process Collected During Laparoscopic (Robotic) Radical Gastrectomy in Gastric Cancer Patients
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: PROCEDURE: Radical Gastric Cancer Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nalbuphine, Fentanyl and no Additive to Local Anaesthetic Mixture
Status: COMPLETED
Conditions: Nalbuphine,Fentanyl and Local Anesthetic Mixture
Interventions: DRUG: Nalbuphine Group|DRUG: Fentanyl Group|DRUG: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Placebo Controlled, Dose Escalation Study to Evaluate Safety, Pharmacokinetics & Efficacy of SAP-001 in Gout Patients
Status: COMPLETED
Conditions: Gout, Hyperuricemia
Interventions: DRUG: SAP-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NMES Efficacy on Patients With NBPP
Status: COMPLETED
Conditions: Neonatal Brachial Plexus Palsy
Interventions: DEVICE: Standard NMES device|DEVICE: Sham NMES device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride
Status: COMPLETED
Conditions: Colorectal Adenomas
Interventions: DRUG: 100mg Berberine hydrochloride|DRUG: 300mg Berberine hydrochloride|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Follow-up Protocol of Colorectal Endoscopic Mucosal Resection Scars
Status: COMPLETED
Conditions: Colorectal Cancer|Recurrence, Local Neoplasm
Interventions: DIAGNOSTIC_TEST: WLE followed by NBI or NBI followed by WLE (crossover design)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Electrical Stimulation for Dysphagia in Head & Neck Cancer Patients
Status: COMPLETED
Conditions: Dysphagia
Interventions: DEVICE: Neurotech NT2000 Neuromuscular Electrical Stimulation (NMES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Acceptance and Commitment Therapy Group for Adjustment Difficulties in Neurological Conditions
Status: COMPLETED
Conditions: Brain Injuries|Multiple Sclerosis|Parkinson Disease|Stroke
Interventions: OTHER: Acceptance and Commitment Therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD30 Targeted CAR-T in Treating CD30-Expressing Lymphomas
Status: RECRUITING
Conditions: Hodgkin Lymphoma|Anaplastic Large Cell Lymphoma
Interventions: BIOLOGICAL: ICAR30 T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation
Status: ACTIVE_NOT_RECRUITING
Conditions: Transpulmonary Pressure|Pressure.Rate Product|Guide to Mechanical Ventilator Management|Extubation Readiness
Interventions: DEVICE: Transpulmonary Pressure measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PROSPECT II & PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial.
Status: COMPLETED
Conditions: Acute Coronary Syndrome (ACS)
Interventions: DEVICE: sham|DEVICE: ABSORB BVS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSL
Status: RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: ONO-4059|DRUG: Rituximab|DRUG: Methotrexate|DRUG: Procarbazine|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lauric Acid, a Dietary Fatty Acid, in Modifying the Latent Reservoir of HIV
Status: RECRUITING
Conditions: HIV Infections
Interventions: DIETARY_SUPPLEMENT: Control group placebo|DIETARY_SUPPLEMENT: Experimental group 1 lauric acid|DIETARY_SUPPLEMENT: Experimental group 2 lauric acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Online, Guided Interventions to Reduce Generalized Anxiety Disorder Among Indian University Students
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Lantern: Guided self-help program|BEHAVIORAL: Mental Health Online: Self-help program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3-Dimensional Conformal Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Recurrent Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: quality-of-life assessment|RADIATION: intensity-modulated radiation therapy|RADIATION: 3-dimensional conformal radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lybrido for Female Sexual Dysfunction
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: Placebo|DRUG: Sildenafil|DRUG: Testosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy
Status: RECRUITING
Conditions: Relapsed Follicular Lymphoma|Refractory Follicular Lymphoma
Interventions: DRUG: Epcoritamab|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Obinutuzumab|DRUG: Bendamustine|DRUG: Vincristine|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Prednisone|DRUG: Investigation agent 2|DRUG: Investigation agent 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moderate to Severe Plaque Psoriasis With Scalp Involvement
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: Etanercept|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy (TRANSACT)
Status: COMPLETED
Conditions: Uncomplicated Malaria
Interventions: DRUG: Artemether-Lumefantrine|DRUG: Dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Noradrenaline Administration Combined With Restrictive Intraoperative Fluid Substitution on Perioperative Outcome in Patients Undergoing Radical Cystectomy
Status: COMPLETED
Conditions: Bladder Cancer|Urinary Diversion
Interventions: PROCEDURE: restrictive intraoperative fluid substitution|PROCEDURE: assessment of the pelvic venous pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety Of PF-00885706 For The Relief Of Symptoms In Subjects With Gastro-esophageal Reflux Disease (GERD)
Status: TERMINATED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: PF-00885706|DRUG: Esomeprazole|DRUG: PF-00885706|DRUG: Esomeprazole|DRUG: PF-00885706|DRUG: Esomeprazole|DRUG: PF-00885706|DRUG: Esomeprazole|OTHER: Placebo|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy, Safety and Tolerability of PENNEL Capsule in the Patients With Chronic Liver Disease
Status: COMPLETED
Conditions: Chronic Liver Disease
Interventions: DRUG: PENNEL capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Softacort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ibrutinib in Combination With Bortezomib and Dexamethasone in Subjects With Relapsed/Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ibrutinib|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A French Study to Evaluate the Usefulness of an Implantable Continuous Glucose Monitoring (CGM) Sensor to Improve Glycemic Control in Participants With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Eversense XL CGM System|DEVICE: Usual SMBG or FGM device used by participants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pemetrexed Disodium and Carboplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: pemetrexed disodium|RADIATION: radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise During Pregnancy on Maternal and Child Health: a Randomized Clinical Trial
Status: COMPLETED
Conditions: Gestational Hypertension|Prematurity|Maternal Post-partum Depression|Maternal Post-partum Weight Retention|Child's Development
Interventions: BEHAVIORAL: Physical Exercise / Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cardiovasculorenal Phenotyping in Fabry Disease Through Noninvasive Testing
Status: RECRUITING
Conditions: Fabry Disease
Interventions: DIAGNOSTIC_TEST: Measures of arterial stiffness and endothelial function|DIAGNOSTIC_TEST: Ambulatory blood pressure monitoring|DIAGNOSTIC_TEST: Cardiopulmonary exercise testing (CPET)|DIAGNOSTIC_TEST: Serum and urine biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Voxelotor CYP and Transporter Cocktail Interaction Study
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Voxelotor|DRUG: Bupropion|DRUG: Repaglinide|DRUG: Flurbiprofen|DRUG: Omeprazole|DRUG: Midazolam|DRUG: Metformin|DRUG: Furosemide|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Influence of Cerebral Blood Flow and PETCO2 on Neuromuscular Function During Passive Heat Stress
Status: COMPLETED
Conditions: Healthy Males|Neuromuscular Function
Interventions: DRUG: Indomethacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Facial Lacerations Repaired With Dermabond Compared With Dermabond With Underlying Steristrips in Pediatric Patients
Status: COMPLETED
Conditions: Facial Laceration
Interventions: PROCEDURE: Dermabond and steristrips|PROCEDURE: Dermabond
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chiropractic and Self-care for Back-Related Leg Pain
Status: COMPLETED
Conditions: Sub-acute and Chronic Back-related Leg Pain
Interventions: OTHER: Home exercise|OTHER: Chiropractic Spinal Manipulative Therapy + Home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antidepressant Treatment Plus Cognitive Behavioral Therapy for Generalized Anxiety Disorder in Older Adults
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Escitalopram|DRUG: Placebo|BEHAVIORAL: Cognitive behavioral therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Pulsatile Insulin Delivery on Cognitive Function- Phase 1
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: Pulsatile IV insulin therapy|PROCEDURE: Effects of Pulsatile IV Insulin on Cognitive functions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Treatment of Recurrent HCV- Infection Post Liver Transplantation in the Era of DAAs
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: treatment of HCV with oral direct acting antiviral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Surgical Peri-implant Mucositis Treatment in Patients With Tissue-level and Bone-level Implants
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: OTHER: Bleeding on Probing change reduction following peri-implant mucositis non surgical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PMZ-2010 (Centhaquine) as a Resuscitative Agent for Hypovolemic Shock
Status: COMPLETED
Conditions: Hypovolemic Shock|Blood Loss
Interventions: DRUG: Normal Saline|DRUG: Centhaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of TPACK-Based Instruction in an Information Resources Course for Nursing Students
Status: RECRUITING
Conditions: Smart Classroom|Nursing Education
Interventions: OTHER: TPACK-Based Blended Learning Instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Determination of Safety and Consumers' Satisfaction of Moussik Versus Desitin Creamy Ointment in Diaper Rash Prophylaxis
Status: WITHDRAWN
Conditions: Diaper Rash
Interventions: OTHER: Moussik Diaper Rash Mousse|OTHER: Desitin Creamy Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Concomitant Therapy of H. Pylori
Status: UNKNOWN
Conditions: Gastritis, Gastric Ulcer, and Duodenal Ulcer
Interventions: DRUG: amoxicillin, clarithromycin, metronidazole, rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Investigational SAR256212 in Combination With SAR245408 in Patients With Solid Tumor Cancers
Status: COMPLETED
Conditions: Solid Tumor Cancers
Interventions: DRUG: MM-121 (SAR256212)|DRUG: SAR245408
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical Application of Iodex® Balm on Local Surface Temperature
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: IODEX® balm|OTHER: Placebo balm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase II Study of Tegafur-Uracil as Maintenance Chemotherapy in Patients With Stage II of Colon Cancer
Status: UNKNOWN
Conditions: MSI-L/MSS|Stage II Colon Cancer
Interventions: DRUG: tegafur-uracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Comprehensibility of Colorectal Cancer Screening Educational Materials: Effects on Patient Knowledge and Motivation
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: BEHAVIORAL: New colorectal cancer screening patient education document|BEHAVIORAL: Traditional colorectal cancer screening education document
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Home-Based Functional Exercise Program in Patients With Patellar Femoral Syndrome Over a 10-Week Period
Status: COMPLETED
Conditions: Patellar Femoral Syndrome
Interventions: BEHAVIORAL: 10 Week Exercise Program|BEHAVIORAL: DVD Program After 10 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intra-oral Neuromuscular Stimulation Training on Snoring and Mild Sleep Apnoea
Status: ENROLLING_BY_INVITATION
Conditions: Snoring|Sleep Apnea, Obstructive
Interventions: DEVICE: eXciteOSA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Trial of Cabozantinib in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Relapsed Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spatial Relationship of I-gelTM and Ambu® AuraOnceTM on Paediatric Airway: A Comparison on Three Dimensional MRI
Status: COMPLETED
Conditions: Pediatric Laryngeal Mask Airway|Spatial Relations With Pediatric Airway|Assessed With Three Dimensional Magnetic Resonance Imaging
Interventions: DEVICE: I-gel TM|DEVICE: Ambu AuraOnce (AO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure
Status: UNKNOWN
Conditions: Heart Failure|Ketosis
Interventions: DIETARY_SUPPLEMENT: KetoneAid KE4 Pro Monoester|DIETARY_SUPPLEMENT: Science in Sport Go Enegy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Brief Family Intervention (BFI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Effectiveness and Safety of ER OROS Paliperidone in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ER OROS paliperidone|DRUG: Placebo|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Therapeutic Effects of Cortical Autograft Implantation in Patients With Cerebral Ischemia
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: OTHER: Autologous transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: PROCEDURE: fatigue assessment and management|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hemopatch Compared to TachoSil in Postoperative Air Leak Duration After Pulmonary Resection
Status: COMPLETED
Conditions: Air Leak From Lung
Interventions: DEVICE: Hemopatch|DEVICE: Tachosil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Look Into How Well Semaglutide Medicine Works at Different Doses in People With Type 2 Diabetes and Overweight
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Dose Escalation SARS-CoV Recombinant S Protein, With and Without Adjuvant, Vaccine Study
Status: WITHDRAWN
Conditions: SARS
Interventions: DRUG: Aluminum hydroxide adjuvant (Alhydrogel®)|OTHER: Phosphate buffered saline Placebo|BIOLOGICAL: Recombinant S protein SARS vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Body Mass Index ≥ 27
Status: COMPLETED
Conditions: Cardiovascular Disease|Overweight
Interventions: DRUG: clopidogrel|DRUG: clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milrinone Versus Dobutamine in Critically Ill Patients
Status: COMPLETED
Conditions: Low Cardiac Output Syndrome|Cardiogenic Shock|Acute Coronary Syndrome|Pulmonary Edema
Interventions: DRUG: Milrinone|DRUG: Dobutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grain Fibre and Gut Health
Status: COMPLETED
Conditions: Intestinal Disorder|Glucose Metabolism Disorders|Inflammation
Interventions: OTHER: Rye bran bread intervention|OTHER: Rye bread intervention|OTHER: Wheat bread diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy (CRT) for Spinal Metastases
Status: COMPLETED
Conditions: Spinal Metastases
Interventions: RADIATION: 20 Gy in 5 fractions|RADIATION: Conventional SBRT: 24 Gy in 2 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multiple Rising Oral Doses of BI 1060469 in Healthy Subjects and Mild Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo to BI 1060469|DRUG: BI 1060469 Healthy|DRUG: Placebo to BI 1060469 asthmatics|DRUG: BI 1060469 asthmatics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Implementation and Cost-evaluation of a Smartphone-based Telemonitoring and Digital Support in Patients With HF
Status: UNKNOWN
Conditions: Heart Failure|Heart Failure NYHA Class II|Heart Failure NYHA Class III|Heart Failure NYHA Class IV
Interventions: DEVICE: Comunicare Solutions Smartphone Application|OTHER: Completing a quality of life (QOL)-questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Closed-loop FiO2 Controller During High Flow Oxygen Treatment In Pediatric Patients (COFICOHFOT)
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DEVICE: Close-loop FiO2 controller|DEVICE: Conventional
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific|Solid Tumor
Interventions: DRUG: BEZ235 + MEK162
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eflornithine and Sulindac in Preventing Colorectal Cancer in Patients With Colon Polyps
Status: COMPLETED
Conditions: Precancerous Condition
Interventions: OTHER: placebo|DRUG: eflornithine|DRUG: sulindac|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Placebo for pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Olaparib|DRUG: Placebo for olaparib|BIOLOGICAL: Bevacizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Bloodletting on Iron Metabolism in Type 1 Hemochromatosis
Status: COMPLETED
Conditions: Hemochromatosis Type 1
Interventions: PROCEDURE: First evaluation phase : no intervention / Second evaluation phase: bloodletting of 7 ml/kg (with a maximum of 500ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS)
Status: UNKNOWN
Conditions: IBS
Interventions: DIETARY_SUPPLEMENT: PHGG|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Follow-up Study of Patients With MPS IIIA Treated With ABO-102
Status: ENROLLING_BY_INVITATION
Conditions: Mucopolysaccharidosis III-A
Interventions: OTHER: No Investigational Product|DRUG: Adjuvant Immunosuppression (IS) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: BEdtime Sublingual TNX-102 SL as Fibromyalgia Intervention Therapy (BESTFIT)
Status: COMPLETED
Conditions: Primary Fibromyalgia
Interventions: DRUG: TNX-102 SL 2.8mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Etodolac Extended Release Tablets USP 600mg Under Fasting Condition
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: Etodolac Extended Release Tablets USP 600mg|DRUG: Etodolac Extended Release Tablets 600mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staccato® Granisetron Multiple Dose PK
Status: COMPLETED
Conditions: Healthy
Interventions: COMBINATION_PRODUCT: 0.5mg AZ-010|COMBINATION_PRODUCT: 1mg AZ-010|COMBINATION_PRODUCT: 3mg AZ-010
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic
Status: COMPLETED
Conditions: Colic|Inflammation
Interventions: DIETARY_SUPPLEMENT: Nutramigen with Enflora|DIETARY_SUPPLEMENT: Nutramigen A+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Inhalation Solution in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: GSP304 (tiotropium bromide) Inhalation Solution|DRUG: GSP304 Placebo Inhalation Solution|DRUG: Spiriva® Respimat® inhalation spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stratifying Psychoses for Personalized REpetitive TMS in Persistent NEgative Symptoms Alleviation
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia|Persistent Negative Symptoms|Progressive Periodic Catatonia|Aviation|Apathy
Interventions: PROCEDURE: Personalized rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: inhaled prostacyclin|DRUG: inhaled prostacyclin|DRUG: prostacyclin|DRUG: subcutaneous and intravenous prostacyclin|DRUG: oral ERA|DRUG: oral PDE5 inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Real-world Effectiveness of Combination Therapy in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone / formoterol metered dose inhaler|DRUG: Fluticasone / salmeterol dry powder inhaler|DRUG: Budesonide / formoterol dry powder inhaler|DRUG: Fluticasone / salmeterol dry powder inhaler|DRUG: Fluticasone / salmeterol metred dose inhaler|DRUG: BUD/FOR dry powder inhaler
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Intrathecal vs Intravenous Dexmedetomidine
Status: NOT_YET_RECRUITING
Conditions: Nausea and Vomiting, Postoperative
Interventions: DRUG: Dexmedetomidine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Pulsatile Hormone Administration on Insulin Action
Status: RECRUITING
Conditions: Insulin Sensitivity
Interventions: OTHER: Continuous Insulin administration during hyperinsulinemic euglycemic clamp test|OTHER: Pulsatile Insulin administration during hyperinsulinemic euglycemic clamp test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER