pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy Comparison Study of Combination Regimens to Treat Advanced Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: First Line Chemotherapy|Capecitabine Plus Cisplatin Versus Capecitabine Plus Paclitaxel|Advanced or Recurrent Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Capecitabine plus cisplatin(XP) versus capecitabine plus paclitaxel(XT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of One-stop Hybrid Revascularization Versus Percutaneous Coronary Intervention for the Treatment of Multi-vessel Disease
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Hybrid MIDCAB/PCI|PROCEDURE: PCI with DES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tenofovir Disoproxil Fumarate (TDF) 300mg in Chinese Subjects With Chronic Hepatitis B (CHB)
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: Tenofovir disoproxil fumarate (TDF) tablets|DRUG: Adefovir dipivoxil (ADV) tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial
Status: COMPLETED
Conditions: Dengue
Interventions: DRUG: Carica Papaya Leaf Extract|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liquid Biopsy Based Multiomics Study for Colorectal Cancer Early Screening
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer|Adenomatous Polyps|Adenoma|Advanced Adenoma
Interventions: DIAGNOSTIC_TEST: multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of RO5024048 in Combination With Ritonavir-Boosted Danoprevir With or Without Copegus (Ribavirin) in Interferon-Naïve Patients With Chronic Hepatitis C Genotype 1 (INFORM-SVR)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Copegus placebo|DRUG: RO5024048|DRUG: danoprevir|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin [Copegus]|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Testosterone Replacement in Hypogonadal Opioid-treated Chronic Pain Patients: A Pilot Study.
Status: WITHDRAWN
Conditions: Pain|Hypogonadism
Interventions: DRUG: Testosterone Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Home-based Exercise Program With Smart Rehabilitation System
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Home-based exercise program with smart rehabilitation system ((Uincare®, D-gate Co.)|OTHER: Conventional home rehabilitation exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT System
Status: COMPLETED
Conditions: Total Knee Replacement|Total Knee Arthroplasty|Pain|Postoperative Pain|Orthopedic Disorders
Interventions: DEVICE: SPRINT Peripheral Nerve Stimulation (PNS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Osilodrostat in Cushing's Disease
Status: COMPLETED
Conditions: Cushing's Disease
Interventions: DRUG: osilodrostat|DRUG: osilodrostat Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor
Status: COMPLETED
Conditions: Sarcoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: vincristine sulfate|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of FB2001 in Hospitalized Patients With Moderate to Severe COVID-19 (BRIGHT Study)
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: FB2001|DRUG: FB2001 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Raman Probe for In-vivo Diagnostics (During Oesophageal) Endoscopy
Status: COMPLETED
Conditions: Barrett Esophagus|Esophageal Cancer
Interventions: DIAGNOSTIC_TEST: endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Influencing Panoramic Imaging Errors With Strips
Status: COMPLETED
Conditions: Panoramic Radiography
Interventions: BEHAVIORAL: Fruit leather on the tongue|BEHAVIORAL: Chewing gum strip|BEHAVIORAL: Celluloid matrix group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 3 Clinical Trial to Evaluate of the Efficacy and Safety of DW9801 in Patients With Primary Dysmenorrhea
Status: UNKNOWN
Conditions: Primary Dysmenorrhea
Interventions: DRUG: Pelubiprofen 45mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Disease Modifying Anti-rheumatic Drug (DMARD) But Not Responding.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: fostamatinib|DRUG: fostamatinib|DRUG: placebo, fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular|Colorectal Neoplasms|Pancreatic Ductal Adenocarcinoma|Biliary Tract Neoplasms|Endometrial Neoplasms|Esophageal Neoplasms
Interventions: DRUG: Pembrolizumab|DRUG: Belzutifan|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)
Status: UNKNOWN
Conditions: Pulmonary Healthy Controls|Interstitial Lung Disease|Idiopathic Pulmonary Fibrosis|Non-specific Interstitial Pneumonia|Sarcoidosis|Granulomatosis With Polyangiitis (Wegener's Disease)
Interventions: DEVICE: multiple breath washout tests|DEVICE: impulse oscillometry|DEVICE: body plethysmography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Tolcapone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC
Status: NOT_YET_RECRUITING
Conditions: NSCLC Stage IV|NSCLC, Stage III
Interventions: DRUG: Repotrectinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Research to Policy Collaboration Model
Status: COMPLETED
Conditions: Legislation|Policy|Child Abuse|Family and Household
Interventions: BEHAVIORAL: Research-to-Policy Collaboration|BEHAVIORAL: Light Touch Policy Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study of Single and Multiple Intravenous Doses of SM17 in Healthy Subjects
Status: RECRUITING
Conditions: 1. Asthma
Interventions: BIOLOGICAL: SM17|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of RG2077 in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: RG2077 (CTLA4-IgG4m)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UK Trial of Percutaneous Tibial Nerve Stimulation in Patients With Faecal Incontinence
Status: COMPLETED
Conditions: Faecal Incontinence|Bowel Incontinence
Interventions: DEVICE: Percutaneous Tibial Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Telerehabilitation in Veterans With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Multiple Sclerosis Home Automated Telemanagement (MS HAT) system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Anxiety Disorders With Trigeminal Nerve Stimulation
Status: ACTIVE_NOT_RECRUITING
Conditions: Panic Disorder|Generalized Anxiety Disorder|Social Anxiety Disorder
Interventions: DEVICE: Trigeminal nerve stimulation - active|DEVICE: Trigeminal nerve stimulation - sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequencing of Radium-223 and Docetaxel in Symptomatic Bone-only Metastatic Castration-resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: Radium-223|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amino Acid Chelated Iron Versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia With Pregnancy: Randomized Controlled Trial
Status: UNKNOWN
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Amino Acid chelated iron tab 15 mg|DRUG: Ferrous Fumarate tab 350 mg( 115 mg elemental iron)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: AGS-003-LNG|DRUG: Carboplatin|DRUG: Abraxane|DRUG: Alimta|DRUG: Cisplatin|DRUG: Taxol|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance (MR) Imaging With Hyperpolarized 13C-Pyruvate +/- 13C,15N-Urea in Patients With Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: hyperpolarized pyruvate +/-urea (13C/15N)|RADIATION: Non-investigational Stereotactic body radiotherapy (SBRT)|PROCEDURE: Radiotherapy (RT)|PROCEDURE: Multi-parametric magnetic resonance imaging (mpMRI)|BIOLOGICAL: Non-interventional hormone therapy|PROCEDURE: Prostate Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Costal Harvesting Technique on Postoperative Donor-site Morbidity: Does Muscle Sparing Technique Cause Less Postoperative Pain ? A Clinical Trial
Status: UNKNOWN
Conditions: Nasal Deformity|Revision Rhinoplasty|Autogenous Rib Graft|Costal Cartilage|Harvesting
Interventions: PROCEDURE: Harvesting rib cartilage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Mobile Medical Unit Study for I'm Fully Empowered4Her
Status: RECRUITING
Conditions: HIV Prevention|Pre-exposure Prophylaxis|PrEP|Prevention|Women's Health|Mobile Health
Interventions: OTHER: I'm Fully Empowered for Her (IFE4Her)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: F@ce 2.0 a Mobile Phone-supported and Family-centred Rehabilitation Intervention After Stroke in Uganda
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Mobile phone supported and family-centred rehabilitation|PROCEDURE: Information and blood pressure measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Nicotine on Arousal, Cognition and Social Cognition in Young and Elderly Healthy Subjects.
Status: COMPLETED
Conditions: Schizophrenia|Cognition Disorders
Interventions: OTHER: A643 (nicotine)|DRUG: placebo|OTHER: A643 (nicotine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Evaluation of Adjuvant Use in Selective Trunk Block
Status: COMPLETED
Conditions: Analgesia|Nerve Blocks|Postoperative Pain, Acute
Interventions: PROCEDURE: Dexamethasone|PROCEDURE: kontrol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1/2 Study of TP-0903 (an Inhibitor of AXL Kinase) in Patients With Previously Treated CLL
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|CLL|SLL|Small Lymphocytic Lymphoma
Interventions: DRUG: TP-0903|COMBINATION_PRODUCT: TP-0903 and ibrutinib combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics and Pharmacodynamics Study of Single and Multiple Dose of SP2086 in Type 2 Diabetes Patients
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: SP2086
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab and Vinorelbine in Elderly Subjects With Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Cetuximab|DRUG: Vinorelbine (Navelbine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AK-01 (LY3295668) in Solid Tumors
Status: COMPLETED
Conditions: Neoplasms|Neoplasm Metastasis|Triple Negative Breast Neoplasms|Head and Neck Neoplasms|Breast Neoplasms|Solid Tumor, Adult|Small Cell Lung Carcinoma
Interventions: DRUG: LY3295668
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or K-RAS Mutant Colon Cancers
Status: TERMINATED
Conditions: Cancer|Neuroendocrine|Ovarian Cancer|Colon Cancer
Interventions: DRUG: JI-101|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin E Versus Vitamin E Plus Pentoxiphyllin in Patients With Nonalcoholic Steatohepatitis: A Prospective Randomized Clinical Trial
Status: WITHDRAWN
Conditions: Non Alcoholic Steatohepatitis
Interventions: DRUG: Vitamin E plus Pentoxiphyllin|DRUG: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Study of the Effects of Orally Administered SAR302503 in Patients With Myelofibrosis
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: SAR302503 (TG101348)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK and PD Study of NPI-001 and Cysteamine Bitartrate
Status: RECRUITING
Conditions: Cystinosis
Interventions: DRUG: Cysteamine Bitartrate|DRUG: N-Acetylcysteine Amide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Of Distraction Methods On Procedure-Related Fear, Anxiety, And Pain During Intramuscular Injection
Status: COMPLETED
Conditions: Pain|Fear|Anxiety|Child, Only
Interventions: BEHAVIORAL: distraction methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: INHALATION CHAMBER MANAGEMENT IN PEDIATRICS: EFFICACY OF AN EDUCATIONAL INTERVENTION IN PATIENTS DIAGNOSED WITH BRONCHOSPASM AND THEIR FAMILY CAREGIVERS.
Status: RECRUITING
Conditions: Bronchospasm
Interventions: BEHAVIORAL: educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older
Status: RECRUITING
Conditions: HIV|Aging
Interventions: OTHER: Customized activity plan|OTHER: Customized nutrition plan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Primary Molars With Deep Caries Using Silver Diamine Fluoride
Status: UNKNOWN
Conditions: Deep Caries
Interventions: DRUG: Silver Diamine Fluoride|DRUG: Glass Ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Evaluating Methotrexate or Leflunomide + Targeted Therapy Versus Methotrexate or Leflunomide + Sulfasalazine + Hydroxychloroquine in Patients With Rheumatoid Arthritis and Insufficient Response to Methotrexate or Leflunomide
Status: RECRUITING
Conditions: Rheumatoid Arthritis|Insufficient Response to Methotrexate or Leflunomide
Interventions: DRUG: Methotrexate + targeted therapy administration|DRUG: methotrexate or leflunomide + sulfasalazine + hydroxychloroquine administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Cancer|Solid Tumor
Interventions: DRUG: Sym021|DRUG: Sym024
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Pharmacodynamics and Pharmacokinetics of Acetylsalicylic Acid Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Healthy Adults.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ASA|DRUG: non-enteric-coated chewable aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ignite Study of the Jewish Family and Children's Service of the Suncoast, Inc.
Status: RECRUITING
Conditions: Intervention|Wait-List Control
Interventions: BEHAVIORAL: Treatment Intervention: Responsible Parenting, Relationships, and Employment Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tripeptide/Hexapeptide Topical and Hybrid Laser Treatment for Acne Scarring
Status: COMPLETED
Conditions: Acne Scars - Mixed Atrophic and Hypertrophic
Interventions: DEVICE: Hybrid fractional laser|OTHER: Alastin Regenerating Skin Nectar with TriHex Technology|OTHER: Cetaphil face cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Intervention to Maintain Physical Capacity and Activity in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: BEHAVIORAL: Behavioural intervention|BEHAVIORAL: Usual care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of 18F-labeled RD2 PET/CT Imaging in the Diagnosis and Treatment of Small Liver Carcinoma
Status: COMPLETED
Conditions: Liver Carcinoma
Interventions: RADIATION: 18F-RD2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pericapsular Nerve Group Block: An Imaging Study for Determination of the Spread of the Injectate Using 3-D CT Scan
Status: COMPLETED
Conditions: Post Operative Pain|Mechanisms of Analgesia
Interventions: PROCEDURE: Pericapsular nerve group block|DRUG: 18 mL ropivacaine 0.5% + 2 mL radiopaque contrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying Time in Infants With Colic
Status: RECRUITING
Conditions: Colic, Infantile
Interventions: DIETARY_SUPPLEMENT: L. reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Liposomal Iron Versus Injectable Iron Sucrose for Anemia Treatment in Non-Dialysis Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: Anemia of Chronic Kidney Disease
Interventions: DRUG: Intravenous Iron Sucrose|DRUG: Oral Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Wood Stove Interventions and Child Respiratory Health
Status: COMPLETED
Conditions: Lower Tract Respiratory Infection
Interventions: BEHAVIORAL: Education Intervention (Tx1)|DEVICE: Air Filtration Unit Treatment (Tx2)|DEVICE: Placebo Intervention (Tx3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Diode Laser 940 nm Versus Electrosurgical Device During Second Stage Implant Surgery on Bone and Soft Tissue Healing
Status: RECRUITING
Conditions: Dental Implant|Bone Healing|Soft Tissue Healing
Interventions: DEVICE: Conventional surgery|DEVICE: Diode laser 940 nm|DEVICE: Electrosurgical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer|Non-squamous Non-small-cell Lung Cancer|Non-Squamous Non-Small Cell Neoplasm of Lung|KEAP1 Gene Mutation|NRF2 Gene Mutation|NFE2L2 Gene Mutation
Interventions: DRUG: Telaglenastat|DRUG: Carboplatin Chemotherapy|DRUG: Pemetrexed Chemotherapy|BIOLOGICAL: Pembrolizumab Immunotherapy|DRUG: Placebo|DIETARY_SUPPLEMENT: Folic acid 400 -1000 μg|DIETARY_SUPPLEMENT: Vitamin B12 1000 μg|DRUG: Dexamethasone 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Effects of Melatonin on Uterine Contractions in Women
Status: RECRUITING
Conditions: Pregnant Women
Interventions: DIETARY_SUPPLEMENT: Melatonin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dienogest Versus Luteal Phase Fluoxetine in the Management of Premenstrual Syndrome
Status: UNKNOWN
Conditions: Premenstrual Syndrome
Interventions: DRUG: Dienogest|DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Culturally Sensitive Behavioral Interventions to Enhance Living Kidney Donation / Living Kidney Transplantation
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: BEHAVIORAL: TALK PLUS|BEHAVIORAL: TALK Standard|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Newly Diagnosed Stage I, Stage II, or Stage III Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: pegfilgrastim|DRUG: melphalan|PROCEDURE: autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy in Treating Patients With Metastatic Breast Cancer, Non-small Cell Lung Cancer, or Prostate Cancer
Status: COMPLETED
Conditions: Male Breast Carcinoma|Prostate Adenocarcinoma|Recurrent Breast Carcinoma|Recurrent Non-Small Cell Lung Carcinoma|Recurrent Prostate Carcinoma|Stage IV Breast Cancer|Stage IV Non-Small Cell Lung Cancer|Stage IV Prostate Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention
Status: NOT_YET_RECRUITING
Conditions: Pediatric HIV Infection|Latent Tuberculosis
Interventions: DRUG: Rifapentine|DRUG: Dolutegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Ventilator-Associated|Pneumonia, Bacterial|Pneumonia|Abdominal Abscess|Bacterial Infections
Interventions: DRUG: Imipenem/cilastatin|DRUG: Imipenem/cilastatin|DRUG: Doripenem|DRUG: Doripenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAIC Plus PD-1 Antibody vs HAIC Plus Sorafenib for Advanced HCC
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: HAIC|DRUG: PD-1 antibody|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS Combined With BWSTT in Stroke With Body Weight Supported Treadmill Training (BWSTT) After Stroke
Status: TERMINATED
Conditions: Stroke
Interventions: DEVICE: High Frequency rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Immunogenicity of a Novel Glucagon Formulation
Status: COMPLETED
Conditions: Drug-specific Antibodies|Diabetes Mellitus
Interventions: DRUG: Nasal Glucagon (NG)|DRUG: Glucagon IM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies
Status: RECRUITING
Conditions: Scabies
Interventions: DRUG: Spinosad Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Customized Acoustic Stimulation for Long Term Medical Benefit for the Relief of Tinnitus and Hyperacusis
Status: UNKNOWN
Conditions: Tinnitus|Hyperacusis
Interventions: DEVICE: Oasis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone
Status: TERMINATED
Conditions: Cancer of the Prostate|Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Trial of DAS181 (Fludase®) in Adult Subjects With Well-Controlled Asthma or Bronchiectasis
Status: COMPLETED
Conditions: Asthma|Bronchiectasis
Interventions: DRUG: DAS181 dry powder, formulation F02|DRUG: Respitose ML006 (DMV-Fonterra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging of Intravenous (IV) Combidex to Brain, Intra-cerebral Tumors and in Central Nervous System (CNS) Inflammation
Status: TERMINATED
Conditions: Brain Neoplasms
Interventions: DRUG: Ferumoxtran-10 (Combidex)|PROCEDURE: Neurosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating the Neural Correlates in Memory Retrieval After HD-tDCS
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DEVICE: active anodal HD-tDCS|DEVICE: sham HD-tDCS|DEVICE: active cathodal HD-tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Internal Radiation Therapy for Hepatocellular Carcinomas With Therasphere: Optimized Dosimetry Versus Standard Dosimetry
Status: COMPLETED
Conditions: Adenoma, Liver Cell
Interventions: RADIATION: Optimized Internal Radiation Therapy|RADIATION: Standard Internal Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open, Randomised, Single Dose, 2-period, 2-sequence Crossover Adhesion Study of Two Different Transdermal Patches Containing Rotigotine.
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DRUG: Rotigotine TTS (Test)|DRUG: Neupro (Reference)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radial Diffusion of the Botulinum Toxin Type A (Botox®): Electromyographic Evaluation of the Frontal Muscle
Status: COMPLETED
Conditions: Wrinkles
Interventions: DRUG: Botulinum Toxin Type-A (day 0)|DRUG: Botulinum Toxin Type-A (day 0)|DRUG: Botulinum Toxin Type-A (day 0)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Formoterol and Beclomethasone Dipropionate in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inuvair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurobiology and Treatment of Reading Disability in NF-1
Status: COMPLETED
Conditions: Neurofibromatosis Type 1|Reading Disabilities
Interventions: BEHAVIORAL: Tutoring Program I|BEHAVIORAL: Tutoring Program II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Human Anti-D (rh) Immunoglobulin (Rhesoglobin) Efficacy, Safety and Some Pharmacokinetics Parameters in Pregnant Women
Status: RECRUITING
Conditions: Pregnancy Related
Interventions: DRUG: Human Anti-D (rh) immunoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III
Status: WITHDRAWN
Conditions: Hypothermia
Interventions: PROCEDURE: Incubator-torso bag|PROCEDURE: Incubator-no plastic bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: Risdiplam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
Status: RECRUITING
Conditions: Degenerative Osteoarthritis|Rheumatoid Arthritis|Posttraumatic Arthropathy|Chronic Instability of Knee|Stiffness of Knee|Deformity Knee
Interventions: DEVICE: Pheno4U
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of IFN-α Combined With CAR-T Cell Therapy in Relapsed and Refractory Acute Lymphoblastic Leukemia（R/R-ALL）
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: COMBINATION_PRODUCT: IFN-α combined with CAR-T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Pirfenidone to Treat Idiopathic Pulmonary Fibrosis(IPF)
Status: UNKNOWN
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Return to Continence and Potency Following Radical Prostatectomy
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: Robot-Assisted Radical Prostatectomy with MLG-COMPLETE Allograft Implantation|DEVICE: MLG-COMPLETE Allograft Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nucel for One and Two Level Lumbar Interbody Fusion
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Spondylolisthesis|Spondylosis
Interventions: PROCEDURE: One or two level lumbar interbody fusion surgery|OTHER: Nucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms
Status: COMPLETED
Conditions: GERD|Acid Reflux Disease|Heartburn|Regurgitation
Interventions: DRUG: AZD3355|DRUG: Placebo|DRUG: Gelusil®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients
Status: COMPLETED
Conditions: Opioid Dependence|Methadone Withdrawal Syndrome
Interventions: DRUG: Lofexidine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 12-Month Open-Label Long-term Safety Study of TNX-102 SL Tablets in Fibromyalgia Patients
Status: COMPLETED
Conditions: Primary Fibromyalgia
Interventions: DRUG: TNX-102 SL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
Status: NOT_YET_RECRUITING
Conditions: Aortic Stenosis
Interventions: OTHER: Transcatheter aortic valve replacement in the absence of B-blocker treatment|OTHER: Transcatheter aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Gatipotuzumab and Tomuzotuximab in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor, Adult
Interventions: DRUG: First part: Gatipotuzumab and Tomuzotuximab; Second part: Gatipotuzumab and Tomuzotuximab or anti-EGFR antibody (Cetuximab, Panitumumab or Necitumumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Omalizumab in the Prevention of Allergen Induced Airway Obstruction in Adults With Mild Allergic Asthma
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: omalizumab|DRUG: omalizumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept Injection|DRUG: Adalimumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kisspeptin in the Evaluation of Delayed Puberty
Status: COMPLETED
Conditions: Delayed Puberty|Kallmann Syndrome|Hypogonadotropic Hypogonadism|GnRH Deficiency
Interventions: DRUG: kisspeptin 112-121|DRUG: GnRH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: H. Pylori Eradication Using Pyklear in Adults in El Paso, Texas: a Pilot Study
Status: UNKNOWN
Conditions: H. Pylori Infection
Interventions: DRUG: bismuth subcitrate potassium, metronidazole,tetracycline hydrochloride and omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Imaging on the da Vinci Surgical System for Intra-operative Near Infrared Imaging of the Biliary Tree (up to 2-weeks Post-operatively)
Status: COMPLETED
Conditions: Gallbladder Disease|Biliary Colic|Gallstones
Interventions: DRUG: Indocyanine green (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Effect of Avacopan at Therapeutic and Supratherapeutic Doses on the QT/QTc Interval in Healthy Participants
Status: COMPLETED
Conditions: Electrocardiography
Interventions: DRUG: Avacopan|DRUG: Moxifloxacin|DRUG: Placebo for avacopan|DRUG: Placebo for moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiolabeled Monoclonal Antibody, Paclitaxel, and Interferon Alfa in Treating Patients With Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: chemotherapy|DRUG: paclitaxel|DRUG: topotecan hydrochloride|RADIATION: lutetium Lu 177 monoclonal antibody CC49|RADIATION: yttrium Y 90 monoclonal antibody CC49
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer With Peritoneal Dissemination
Interventions: DRUG: Prospidelong|PROCEDURE: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Spinal Manipulative Therapy Protocols
Status: COMPLETED
Conditions: Low Back Pain
Interventions: BEHAVIORAL: SMT|BEHAVIORAL: Mobilizing Exercises|BEHAVIORAL: Activation Exercises|BEHAVIORAL: SMT extended
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individual Versus Standard Follicle Stimulating Hormone Dose for Controlled Ovarian Stimulation and Insemination
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: rFSH drug dose|DRUG: "Standard" rFSH dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
Status: UNKNOWN
Conditions: Preterm Labor|Preterm Birth|Preterm Premature Rupture of Membrane|Cervical Incompetence|Miscarriage in Second Trimester|Miscarriage in Third Trimester
Interventions: COMBINATION_PRODUCT: LACTIN-V
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: H5 Vaccine Alone or With Adjuvant in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Aluminum hydroxide|BIOLOGICAL: Inactivated Influenza A/H5N1 Vaccine (sanofi pasteur pre-adsorbed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Importance of Neurogenic Inflammation in the Angiogenic Response of the Dental Pulp as a Defensive Response
Status: COMPLETED
Conditions: Occlusal Trauma|Orthodontic Appliance Complication
Interventions: DEVICE: Block of resin|DEVICE: Buccal tube, Bracket and 0.0017 × 0.025 in titanium molybdenum alloy wire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Dietary Intake of Cod Residual Material Meal on Lipid Regulation, Glucose Regulation and Body Composition in Physically Active Adults
Status: COMPLETED
Conditions: Physical Activity|Healthy
Interventions: DIETARY_SUPPLEMENT: Cod meal from residual material|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy Study of the Draeger Jaundice Meter (JM-105) in Neonates of ≥ 24 Weeks of Gestational Age
Status: COMPLETED
Conditions: Hyperbilirubinemia|Neonatal Jaundice
Interventions: DEVICE: JM-105
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Proactive Palliative Care for Patients With Ventricular Assist Devices (VAD) and Their Families
Status: COMPLETED
Conditions: Heart Failure|End-stage Disease
Interventions: BEHAVIORAL: Palliative Care|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gene Transfer Study of ABO-102 in Patients With Middle and Advanced Phases of MPS IIIA Disease
Status: TERMINATED
Conditions: MPS IIIA|Sanfilippo Syndrome|Sanfilippo A|Mucopolysaccharidosis III
Interventions: DRUG: ABO-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promiseb Topical Cream for Cradle Cap
Status: COMPLETED
Conditions: Cradle Cap|Infantile Seborrheic Dermatitis
Interventions: DEVICE: Promiseb Topical Cream|OTHER: Bland emollient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Wavefront Optimized (WFO) Profile in Non-anterior Astigmatisms
Status: COMPLETED
Conditions: Astigmatism
Interventions: OTHER: Laser in situ keratomileusis (LASIK)|OTHER: Photorefractive keratectomy (PRK)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saturated Fat Versus Monounsaturated Fat and Insulin Action
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: High palmitate or high oleate diet.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: BIOLOGICAL: Tislelizumab|DRUG: Pamiparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT