pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Quantification of Viral Load in the Upper Respiratory Tract in Patients Treated With Olsetamivir for Influenza
Status: UNKNOWN
Conditions: Flu
Interventions: DIAGNOSTIC_TEST: Rapid test for diagnosis orientation|DIAGNOSTIC_TEST: quantitative PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Real Versus Sham Manual Therapy for RCRSP
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Manual therapy thoracic spine|OTHER: Manual therapy glenohumeral joint|OTHER: Sham thoracic manual therapy|OTHER: Sham glenohumeral manual therapy|OTHER: Therapeutic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy, Safety and Immunogenicity of GX-19N in Healthy Individuals Who Have Received COVID-19 Vaccines
Status: WITHDRAWN
Conditions: SARS-CoV2 Infection
Interventions: BIOLOGICAL: GX-19N|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Web-Based and Face-to-face Training Given to Office Workers on Health Beliefs and Physical Activity Levels Regarding Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Face-to-face training|BEHAVIORAL: web-based training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Pramipexole on the QT Interval of the ECG in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pramipexole extended-release (ER) tablets|DRUG: Pramipexole immediate-release (IR) tablets|DRUG: Moxifloxacin|DRUG: Pramipexole Placebo|DRUG: Moxifloxacin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography (PET) Study With (11C) Flumazenil to Determine Central GABAA Receptor Occupancy of AZD6280
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: AZD6280|DRUG: (11C) flumazenil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous Lidocaine and Quality of Recovery After Cesarean Delivery
Status: WITHDRAWN
Conditions: Pregnancy
Interventions: DRUG: Lidocaine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior Mesenteric Vein in Rectal Cancer Patients.
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer
Interventions: OTHER: Vein ligation first|OTHER: Artery ligation first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol-fentanyl-ketamine (PFK) Combination Versus General Anesthesia Using Propofol and Fentanyl in Patients Undergoing Endoscopic Procedures.
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: PK general anesthesia|DRUG: PFK combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Formulations of AZD5363 and the Effect of Food on Pharmacokinetic Exposure, Safety and Tolerability
Status: COMPLETED
Conditions: Advanced Solid Malignancy,|Safety and Tolerability,|Pharmacokinetics, Pharmacodynamics,|Tumour Response,
Interventions: DRUG: AZD5363|DRUG: AZD5363
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Eltrombopag in Subjects With AML
Status: COMPLETED
Conditions: Acute Leukaemia
Interventions: DRUG: Daunorubicin|DRUG: Cytarabine|DRUG: Eltrombopag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Optimal Diagnosis and Treatment Strategy of Major Depressive Disorder Based on Anhedonia
Status: RECRUITING
Conditions: Outpatients / Inpatients With Depression
Interventions: DRUG: Escitalopram|DRUG: Escitalopram+Aripiprazole|DRUG: Escitalopram+omega-3 PUFAs|DRUG: Escitalopram+Aripiprazole+omega-3 PUFAs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double Foley Catheter For Cervical Ripening
Status: COMPLETED
Conditions: Induction of Labour
Interventions: DEVICE: Double Foley Catheter For Ripening The Unfavorable Cervix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: PROVIZ - a Machine Learning Software, to Support Targeting of Prostate Biopsies on MR Images in Biopsy-naive Patients
Status: RECRUITING
Conditions: Prostate Cancer Diagnosis
Interventions: DEVICE: Automatic image analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Therapy With Bevacizumab (BEV), Epirubicin, and Cyclophosphamide Followed by Docetaxel Plus Trastuzumab and BEV Given as Neoadjuvant or Adjuvant Therapy for Women With Locally Advanced HER2 Positive Invasive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Trastuzumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idelalisib With Rituximab, Ifosfamide, Carboplatin, Etoposide (RICE) in Children and Adolescents
Status: WITHDRAWN
Conditions: Diffuse Large B-Cell Lymphoma|Mediastinal B-cell Lymphoma
Interventions: DRUG: Idelalisib|DRUG: Rituximab|DRUG: Ifosfamide|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Gemcitabine Plus AG-013736 Versus Gemcitabine For Advanced Pancreatic Cancer.
Status: COMPLETED
Conditions: Carcinoma, Pancreatic Ductal
Interventions: DRUG: AG-013736|DRUG: Gemcitabine|DRUG: Gemcitabine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Linsitinib in Treating Patients With Asymptomatic or Mildly Symptomatic Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: linsitinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Single and Multiple Dose of GLPG1972
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG1972 single ascending doses|DRUG: Placebo single dose|DRUG: GLPG1972 multiple ascending doses|DRUG: Placebo multiple doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Dimebon in Patients With Huntington Disease
Status: COMPLETED
Conditions: Huntington Disease
Interventions: DRUG: Dimebon|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Approach to Stop Hypertension With Sodium (Na) Reduction for Chinese Canadians
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: DASHNa-CC|BEHAVIORAL: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Pilot Study of Dirithromycin of (Abdi İbrahim İlaç San.Ve.Tic.A.Ş,Turkey) in Healthy Subjects Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DYNABAC 250 MG ENTERIC COATED TABLET|DRUG: DIRITHROMYCIN 500 MG ENTERIC COATED TABLET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Antiplatelet Therapy Versus Recommended Dose of Prasugrel
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Modification of Prasugrel based on a biological assay|DRUG: prasugrel / clopidogrel|DEVICE: Verify Now
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Regional Anaesthesia and Genetic Factors in the Development of Chronic Pain Following Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthroplasty, Replacement, Knee|Chronic Pain Post-Proceduraal
Interventions: PROCEDURE: Spinal anaesthesia|PROCEDURE: General anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of QVA149 in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: QVA149|DRUG: Umeclidinium/vilanterol|DRUG: Placebo (umeclidinium/vilanterol)|DRUG: Placebo (QVA149)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vinblastine and Methotrexate in Children With Pulmonary Vein Stenosis
Status: COMPLETED
Conditions: Intraluminal Pulmonary Vein Stenosis
Interventions: DRUG: Vinblastine|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Explorative Trial to Explore the Safety, Acceptability and Vaginal Bleeding Pattern of Three Etonogestrel-releasing Medicated Intrauterine Systems (Study P06060)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Etonogestrel-releasing IUS|DRUG: Etonogestrel-releasing IUS|DRUG: Etonogestrel-releasing IUS|DEVICE: Multiload-cu 375®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Does Erythropoietin Improve Outcome in Very Preterm Infants?
Status: COMPLETED
Conditions: Intracranial Hemorrhage|Periventricular Leukomalacia|Cerebral Palsy|Developmental Psychomotor Disorders
Interventions: DRUG: Recombinant human Erythropoietin|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Titration of Inspired Oxygen to Decrease the Incidence of Postoperative Pulmonary Complications
Status: RECRUITING
Conditions: Unrecognized Condition
Interventions: OTHER: Titration of Inspired Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety, Pharmacokinetic and Pharmacodynamic Study of COR-1, an Anti-ß1 Receptor Antibody Cyclopeptide
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: COR-1|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Assess the Excretion Balance and Pharmacokinetics of a Single Oral Dose of [14C]SB-681323 in Healthy Adult Males
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: A single 10 milligram (50 microcurie) oral dose of [14C]SB-681323
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Porcine Xenograft Versus Second Intention Healing
Status: TERMINATED
Conditions: Wound Healing and Scar Quality Following Mohs Surgery and Excisional Dermatologic Surgery
Interventions: DEVICE: Porcine xenograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing 2 Diagnostic Strategies for Preoperative Localization of Parathyroid Adenoma in Primary Hyperparathyroidism:TEMP / CT With Tc99m-sestaMIBI or PET / CT With F18-choline in First Intention
Status: COMPLETED
Conditions: Parathyroid Adenoma|Hyperparathyroidism|F18-choline
Interventions: DIAGNOSTIC_TEST: MIBI scintigraphy|DIAGNOSTIC_TEST: F18-choline PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of PF-07248144 in Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced or Metastatic ER+ HER2- Breast Cancer|Locally Advanced or Metastatic Castration-resistant Prostate Cancer|Locally Advanced or Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: PF-07248144|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: Palbociclib|DRUG: PF-07220060
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Concurrent Durvalumab and Radiotherapy for for Stage III Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer|Lung Cancer Stage III
Interventions: RADIATION: Thoracic RT and Durvalumab|DRUG: Consolidative Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study of [14C]-IDV184001AN ([14C]-IDV184001) in Healthy Adult Male Participants
Status: COMPLETED
Conditions: Opioid Use Disorder
Interventions: DRUG: [14C]IDV184001AN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Segmental Control Program on Hamstring Peak Torque in Patients With Non-specific Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: local segmental control and closed kinetic chain|OTHER: local segmental control and open kinetic chain|OTHER: traditional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrating HIV and Depression Self-Care to Improve Adherence in Perinatal Women
Status: COMPLETED
Conditions: HIV Infections|Depression
Interventions: BEHAVIORAL: BEST-maCARE|BEHAVIORAL: Attention Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Telemonitoring on CPAP Treatment Compliance in Obstructive Sleep Apnea (OSA) Patients
Status: COMPLETED
Conditions: Sleep Apnea Syndrome
Interventions: OTHER: Standard follow-up|OTHER: Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multicenter Vitamin E Trial in Aging Persons With Down Syndrome
Status: COMPLETED
Conditions: Alzheimer's Disease|Down Syndrome
Interventions: DRUG: Alpha-Tocopherol|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Immunogenicity of Influenza Vaccine in HIV Infected Individuals
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: Fluzone®|BIOLOGICAL: Fluzone®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Weight-Reducing Effect and Safety of Rimonabant In Obesity in ASIA (RIO-ASIA)
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Rimonabant (SR141716)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold Induced Activation of Brown Adipose Tissue in Winter Swimmers
Status: COMPLETED
Conditions: Adipose Tissue|Brown Adipose Tissue|Brown Fat|Uncoupling Protein 1|Adipokines|Proteomics|Infra-red Thermography|BAT|Winter Swimmers|Type2 Diabetes|Proteins
Interventions: PROCEDURE: Cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Reflective Breathing Therapy Compared With Conventional Breathing Therapy in Patients With Chronic Obstructive Pulmonary Disease (COPD) III-IV
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: conventional breathing therapy|OTHER: reflectory breathing therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm
Interventions: DRUG: Hydrocodone|DRUG: Hydromorphone|DRUG: Levorphanol|DRUG: Morphine|DRUG: Oxycodone|DRUG: Oxymorphone|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ready, Set, Go! A Physical Fitness Intervention for Children With Mobility Challenges
Status: ENROLLING_BY_INVITATION
Conditions: Cerebral Palsy|Myelomeningocele|Arthrogryposis|Motor Skills Disorders|Gross Motor Development Delay
Interventions: BEHAVIORAL: adapted Chicago Run running program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors
Status: COMPLETED
Conditions: Childhood Astrocytoma|Childhood Atypical Teratoid/Rhabdoid Tumor|Diffuse Intrinsic Pontine Glioma|Glioma|Recurrent Childhood Anaplastic Oligodendroglioma|Recurrent Childhood Brain Neoplasm|Recurrent Childhood Glioblastoma|Recurrent Childhood Medulloblastoma|Recurrent Primitive Neuroectodermal Tumor|Refractory Brain Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Sargramostim|BIOLOGICAL: Wild-type Reovirus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation to Improve Functioning in Veterans With PTSD
Status: RECRUITING
Conditions: PTSD
Interventions: DEVICE: TMS 1 hz|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Grass Pollen Sublingual Immunotherapy
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: DRUG: Oralgen|DRUG: grass pollen extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema
Status: COMPLETED
Conditions: Lymphedema Arm
Interventions: DRUG: Lumason|DRUG: Optison|DRUG: Definity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I/II Dose-escalation Study to Evaluate Safety, PK and Efficacy of TLC590 for Postsurgical Pain Management
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: DRUG: TLC590|DRUG: Naropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spectrophotometric Evaluation of Chlorhexidine Pigmentations After Oral Surgery: a Prospective Randomized Clinical Trial
Status: COMPLETED
Conditions: Staining Effect of Chlorhexidine
Interventions: DRUG: Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Adjunctive Treatment of Aripiprazole in Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Semaglutide's Effect on Renal Hemodynamics and Function in Patients With Type 2 Diabetes Mellitus and Nephropathy
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Kidney Disease, Chronic
Interventions: DRUG: Semaglutide, 0.5 mg/mL|DRUG: Placebo, Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal
Status: COMPLETED
Conditions: Atherosclerosis|Metabolic Syndrome
Interventions: BEHAVIORAL: Prolonged sitting with exercise|BEHAVIORAL: Prolonged sitting without exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of FES Cycling After a Severe Form of COVID-19
Status: RECRUITING
Conditions: Covid19|Ventilators, Mechanical|Respiratory Distress Syndrome
Interventions: BEHAVIORAL: Physical therapy that include a standardized cycling training with functional electrical stimulation|BEHAVIORAL: Physical therapy that include a standardized cycling training with no additional functional electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo-controlled, Randomized Trial of a Simplified Biofeedback Technique for the Treatment of Rumination
Status: COMPLETED
Conditions: Rumination Disorders
Interventions: BEHAVIORAL: Biofeedback|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Real-World Registry - The Vivally® System
Status: ENROLLING_BY_INVITATION
Conditions: Urinary Incontinence|Urinary Urge Incontinence
Interventions: DEVICE: Vivally® System Wearable, Non-Invasive Neuromodulation System, and Mobile Application
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sleep Hygiene Intervention on Undergraduate Students' Sleep and Stress
Status: COMPLETED
Conditions: Stress, Emotional|Sleep Disturbance
Interventions: BEHAVIORAL: Sleep Hygiene Intervention|BEHAVIORAL: Non-behavioral Sleep Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Mavacamten Capsule 1|DRUG: Mavacamten Capsule 2|DRUG: Mavacamten Capsule 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of an Innovative eHealth Transition Intervention on Self-Management Skills Among Young Adults With Congenital Heart Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Heart Disease|Congenital Heart Disease in Adolescence
Interventions: BEHAVIORAL: Use of the CHD app|BEHAVIORAL: Nurse-led intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two ACL Reconstruction Techniques: All-inside Versus Complete Tibial Tunnel Technique
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: Anterior Cruciate Ligament Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigator Initiated Phase 1 Study of TBI-1301
Status: UNKNOWN
Conditions: Solid Tumors
Interventions: DRUG: TBI-1301|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Participants With Previously Treated Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AndroGel in Men With Major Depression and Incomplete Response to Antidepressant Treatment
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Testosterone gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duration of Clopidogrel Therapy After Drug-Eluting Stent (DES-LATE)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Aspirin monotherapy|DRUG: Aspirin,Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONO-7475-03: ONO-7475 Phase I Study An Open-label, Uncontrolled Study of ONO-7475 in Combination With Osimertinib in EGFR Gene Mutation-positive Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: EGFR Mutated, Stage IIIB/IIIC/IV or Recurrent, NSCLC
Interventions: DRUG: ONO-7475|DRUG: Osimertinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calming Alternatives Learned During MRI-Guided Breast Biopsy
Status: COMPLETED
Conditions: Breast Cancer|Breast Pain|Pain, Acute|Anxiety|Coping Skills|Self Efficacy
Interventions: BEHAVIORAL: Controlled Breathing Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Nicardipine|DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Tai Chi Versus Conventional Exercise to Alleviate Depression in Insomniacs
Status: RECRUITING
Conditions: Depressive Symptoms|Chronic Insomnia
Interventions: BEHAVIORAL: Tai Chi|BEHAVIORAL: Conventional exercise|BEHAVIORAL: Health Education Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Spine Motion During Tracheal Intubation: Video Laryngoscope vs Rigid Video Stylet
Status: COMPLETED
Conditions: Intubation
Interventions: DEVICE: rigid video stylet intubation|DEVICE: video laryngoscope intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer in Japan
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: 177Lu-PSMA-617|RADIATION: 68Ga-PSMA-11|OTHER: Best supportive/best standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Arterial Waveforms and Oxygen Pressure During Supervised Exercise for Peripheral Artery Disease
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DIAGNOSTIC_TEST: transcutaneous oxygen pressure|PROCEDURE: Supervised Exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Imaging of Totally Blocked Arteries
Status: COMPLETED
Conditions: Atherosclerosis|Peripheral Artery Disease|Intermittent Claudication|Chronic Total Aterial Occlusion
Interventions: DRUG: MS-325 Injection (Gadofosveset Trisodium)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Deep Brain Stimulation (DBS) for the Suppression of Tremor
Status: COMPLETED
Conditions: Tremor|Action Tremor|Essential Tremor|Tremor, Limb
Interventions: DEVICE: ANS Totally Implantable Deep Brain Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Human Platelet Derivatives on Dental Implant
Status: NOT_YET_RECRUITING
Conditions: Platelet-Rich Fibrin|Dental Implantation|Bone Substitute
Interventions: BIOLOGICAL: PRF membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SAMe for Hot Flashes
Status: COMPLETED
Conditions: Healthy, no Evidence of Disease|Hot Flashes
Interventions: DRUG: S-adenosyl-L-methionine disulfate p-toluene-sulfonate|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Association Between the Transfer of Lactobacilli From the Gastrointestinal Tract to the Vagina and the Prevention / Eradication of Abnormal Vaginal Flora in High Risk Pregnancies
Status: TERMINATED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Urex Plus|OTHER: Placebo|DIETARY_SUPPLEMENT: Probotic capsule containing L. rhamnosus GR-1and L. reuteri RC-14
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aspirin as a Pre-Treatment for Exercise in Multiple Sclerosis
Status: COMPLETED
Conditions: Fatigue|Overheating
Interventions: DRUG: Acetylsalicylic acid at 1st visit, then Placebo at 2nd visit|DRUG: Placebo at 1st visit, then Acetylsalicylic acid at 2nd visit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Sequential Open-label Study to Evaluate the Efficacy and Safety of Sorafenib Followed by Pazopanib Versus Pazopanib Followed by Sorafenib in the Treatment of Advanced / Metastatic Renal Cell Carcinoma (SWITCH-II)
Status: COMPLETED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Sorafenib+Pazopanib|DRUG: Pazopanib+Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Tamsulosin on PE Compared With Paroxetine Hydrochloride
Status: UNKNOWN
Conditions: Premature Ejaculation
Interventions: DRUG: Tamsulosin|DRUG: Paroxetine Hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Effects of Exercise-related Hypoglycaemia in Patients With Type 1 Diabetes (Hypo Heart Exercise)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Arrhythmia
Interventions: OTHER: Exercise-related hypoglycaemia|OTHER: Hypoglycaemia under resting conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daily Duration of Compression Treatment in Patients With Symptomatic Chronic Venous Disease
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Venous Insufficiency|Varicose Veins of Lower Limb
Interventions: DEVICE: Compression socks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Caregiver-mediated Health Educational Intervention to Improve Constipation Status of Primary School Children
Status: COMPLETED
Conditions: Constipation
Interventions: BEHAVIORAL: Constipation Health Education Intervention Course|BEHAVIORAL: General Health Course
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Use of Airtime Structure to Improve Interactive Voice Response Surveys in Bangladesh and Uganda
Status: COMPLETED
Conditions: Surveys and Questionnaires|Noncommunicable Diseases
Interventions: OTHER: 1X Airtime Incentive|OTHER: Lottery Airtime Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Voriconazole Pharmacokinetics in Children With Gastrointestinal Graft Versus Host Disease
Status: COMPLETED
Conditions: Graft Versus Host Disease|Stem Cell Transplantation
Interventions: DRUG: voriconazole|DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of BOSU Exercises Added to Complete Decongestive Treatment on Balance in Breast Cancer-associated Lymphedema.
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Related Lymphedema
Interventions: PROCEDURE: Complete decongestive treatment program|PROCEDURE: Balance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Symptomatic Gastric Sleeve Stenosis After Laparoscopic Sleeve Gastrectomy
Status: WITHDRAWN
Conditions: Gastric Stenosis
Interventions: PROCEDURE: Endoscopic pneumatic balloon dilation|PROCEDURE: Gastric peroral endoscopic myotomy (G-POEM)|PROCEDURE: Roux-en-Y gastric bypass (RYGB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Plus Donor White Blood Cell Infusion in Treating Patients With Relapsed Hematologic Cancer Following Donor Peripheral Stem Cell Transplantation
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cyclophosphamide|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of NBI-1070770 in Adults With Major Depressive Disorder
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: NBI-1070770|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Muscle Energy Technique Combined With Strengthening of Deep Neck Flexors With and Without Core Stability Exercise in Upper Cross Syndrome Patients.
Status: COMPLETED
Conditions: Upper Cross Syndrome|Forward Head Posture
Interventions: OTHER: Muscle energy technique (MET)|OTHER: Core stability exercises:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Switching From Generic Selective Serotonin Reuptake Inhibitors (SSRIs) and Selective Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) to Three Different Dose Initiation Strategies With Vilazodone
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: Vilazodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Pantoprazole 40 mg DR Tablets and Protonix 40 mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pantoprazole 40 mg DR Tablet vs. Protonix 40 mg DR Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Catheter Insertion Site for Continuous Peripheral Nerve Blocks
Status: COMPLETED
Conditions: Upper-extremity Surgery|Post-operative Pain
Interventions: PROCEDURE: Supraclavicular vs. Infraclavicular ropivicaine infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pramipexole to Enhance Social Connections
Status: RECRUITING
Conditions: Anxiety Disorders|Anxiety|Depression|Social Disconnection
Interventions: DRUG: Pramipexole Pill|DRUG: Placebo Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Humidification Devices During Non Invasive Ventilation, in Acute Respiratory Failure
Status: TERMINATED
Conditions: Respiratory Failure|COPD|Hypoxemia|Non Invasive Ventilation
Interventions: DEVICE: Humidification devices: HH vs HME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Factors Predicting Erythropoietin Responsiveness in Children on Hemodialysis at Sohag University Hospital
Status: UNKNOWN
Conditions: Pediatric Patients on Hemodialysis
Interventions: DIAGNOSTIC_TEST: seum zinic,vit B12, parathyriod function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Computerized Template Entry for Compensation and Pension (C&P) Examinations
Status: COMPLETED
Conditions: Joint Diseases
Interventions: OTHER: Computer based template for exam documentation|OTHER: Dictation for exam documentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Pharmacokinetic (PK) Study of Intravenous (IV) Acetaminophen Administration in Pediatric Inpatients
Status: COMPLETED
Conditions: Pain|Fever
Interventions: DRUG: IV Acetaminophen|DRUG: IV Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintaining and imPrOving the intrinSIc capaciTy Involving Primary Care and caregiVErs
Status: UNKNOWN
Conditions: Frailty|Frailty Syndrome|Frail Elderly Syndrome
Interventions: DEVICE: Frailty multicomponent intervention supported by POSITIVE|OTHER: Frailty multicomponent intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow up After SG vs RYGB vs OAGB
Status: COMPLETED
Conditions: Weight Loss
Interventions: PROCEDURE: Sleeve Gastrectomy|PROCEDURE: Roux-en-Y gastric bypass|PROCEDURE: One-Anastomosis Gastric Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: TRx0237 150 mg/day|DRUG: TRx0237 250 mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ADH300004 in Surgically Resected Primary or Metastatic Colorectal Cancer and Liver Biopsy, or Planned Hepatic Resection
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: ADH300004
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ATG-018 (ATR Inhibitor) Treatment in Patients With Advanced Solid Tumors and Hematological Malignancies
Status: TERMINATED
Conditions: Advanced Solid Tumors|Hematological Malignancies
Interventions: DRUG: ATG-018
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Gut Microbiota After High-dose Dual Therapy Combined With Probiotics for Helicobacter Pylori Eradication
Status: RECRUITING
Conditions: Gut Microbiota|Metabolic Disturbance|Helicobacter Pylori Eradication
Interventions: DRUG: Vonoprazan|DRUG: Amoxicillin|DRUG: Bacillus subtilis enteric-coated capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Repeat Insult Patch Test of Wound Dressings
Status: COMPLETED
Conditions: Skin Sensitization
Interventions: DEVICE: IV Clear™|DEVICE: Tegaderm CHG™|DEVICE: Silicone Vehicle Control Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: DaHuang GangTsao Tang to Improve the Appetite Loss Condition of Cancer Patients
Status: COMPLETED
Conditions: Non-organic Loss of Appetite
Interventions: DRUG: DaHuang GanTsao Tang
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Study of the Combination of Mitoxantrone, Etoposide and Gemtuzumab Ozogamicin (MEGO) for Patients With Acute Myeloid Leukemia Refractory to Initial Standard Induction Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: mitoxantrone + etoposide + gemtuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor DNA and Follow-up of BRCA1 Mutation Carriers (CirCa 01)
Status: COMPLETED
Conditions: Women With BRCA1 Germline Deleterious Mutation
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of Second Intraperitoneal (I.P.) Infusion Cycle of Catumaxomab in Patients With Malignant Ascites
Status: COMPLETED
Conditions: Malignant Ascites Due to Epithelial Carcinoma
Interventions: DRUG: catumaxomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Encorafenib|BIOLOGICAL: Cetuximab|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Database Assessment of Clinical Effectiveness in Type 2 Diabetes Patients Treated With Liraglutide From Primary Care Centers in Sweden
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: sitagliptin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I Dose Escalation and Expansion of Oral BAY 1143269 in Combination With Intravenous Docetaxel
Status: TERMINATED
Conditions: Medical Oncology
Interventions: DRUG: BAY1143269 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone
Status: COMPLETED
Conditions: Hyperkalaemia|Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Sodium zirconium cyclosilicate|DRUG: Placebo|OTHER: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
Status: COMPLETED
Conditions: MELAS Syndrome
Interventions: DRUG: L-Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Autoantigens in EGPA and Severe Eosinophilic Asthma
Status: UNKNOWN
Conditions: Churg-Strauss Syndrome|Eosinophilic Asthma|Eosinophilic Esophagitis|Eosinophilic Pneumonia
Interventions: DIAGNOSTIC_TEST: Autoantibody ELISA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p