pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ambu® Aura-ITM Versus Ambu Aura GainTM for Fiberoptic Intubation in Children
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DEVICE: Ambu Aura GainTM|DEVICE: Ambu® Aura-ITM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Six-Month Safety and Antiviral Study in HIV-1 Seropositive, AZT-Experienced Patients With CD4 Counts Less Than or Equal to 50 Cells/mm3 to Evaluate MK-639 Alone Versus Zidovudine (AZT) and 3TC Versus the Combination of MK-639 With AZT/3TC
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: OTI-010 for Graft-Versus-Host Disease Prophylaxis in Treating Patients Who Are Undergoing Donor Peripheral Stem Cell Transplantation for Hematologic Malignancies
Status: WITHDRAWN
Conditions: Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: autologous expanded mesenchymal stem cells OTI-010|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: methotrexate|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: JNJ-77242113|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center
Status: WITHDRAWN
Conditions: Colonoscopy|Positive-Pressure Respiration
Interventions: DEVICE: Nasal Cannula|DEVICE: Nasal Positive Airway Pressure System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Longitudinal Phenotyping of Bariatric Surgery Patients
Status: COMPLETED
Conditions: Obesity|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: Laparoscopic Roux-en-Y Gastric Bypass|PROCEDURE: Laparoscopic Sleeve Gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Additive Lorazepam on Patient Satisfaction as a Premedication in Diagnostic Flexible Bronchoscopy
Status: UNKNOWN
Conditions: Patient Satisfaction for Bronchoscopy
Interventions: DRUG: Lorazepam|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NICU2HOME+: Supporting Illinois Families
Status: ACTIVE_NOT_RECRUITING
Conditions: Premature Birth|NICU|Premature|Infant
Interventions: OTHER: Group 1: Standard of Care|OTHER: Group 2: NICU2HOME+ app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repeat Dose Subcutaneous Rhumatoid Arthritis Efficacy Study
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: subcutanious administration|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of TPN171H on the QT/QTc Interval in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: TPN171H 10 mg Group|DRUG: TPN171H 30 mg Group|DRUG: TPN171H 40 mg Group|DRUG: TPN171H 50 mg Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Continuous Infusion of Intravenous Nefopam on Postoperative Pain and Opioid Consumption After VATS
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Nefopam 80mg/day|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Examine the Effect of Gastric Bypass Surgery on Venlafaxine ER Blood Levels
Status: COMPLETED
Conditions: Bariatric Surgery|Gastric Bypass|Roux-en-Y Gastric Bypass
Interventions: DRUG: venlafaxine ER (extended-release) 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Lornoxicam and Paracetamol for Pre-emptive Intravenous Analgesia for Elective Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Inguinal Hernia|Postoperative Pain
Interventions: OTHER: Sterile Saline|DRUG: Intravenous lornoxicam|DRUG: Intravenous paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Carotid Peak Systolic Velocity Variation With Aortic Peak Systolic Velocity Variation in Pediatric Non-Cardiac Surgery
Status: COMPLETED
Conditions: Anesthesia, General|Anesthesia, Endotracheal|Mechanical Ventilation|Fluid Responsiveness
Interventions: OTHER: Measurement of aortic and carotid Doppler peak systolic velocity variation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status
Status: UNKNOWN
Conditions: Inflammatory Disorder of Immune System|Sepsis
Interventions: OTHER: blood sample collection|DRUG: Midazolam|DRUG: Morphine|PROCEDURE: Sedation interruption
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evidence Based Protocol for Oxytocin Administration in Vaginal Delivery
Status: WITHDRAWN
Conditions: Uterine Atony|Postpartum Hemorrhage
Interventions: DRUG: Oxytocin|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Preliminary Pharmacokinetics and Bronchodilator Properties of V0162
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Bronchodilatator|DRUG: Bronchodilatator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Venetoclax and Azacitidine in Advanced BCR-ABL Negative Myeloproliferative Neoplasms
Status: RECRUITING
Conditions: Myeloproliferative Neoplasm
Interventions: DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Cirrhosis|Hepatocellular Carcinoma
Interventions: DRUG: ARQ 197
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Efficacy Of The Combination Of Axitinib With Pemetrexed And Cisplatin In The Treatment Of Non-Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: axitinib|DRUG: axitinib|DRUG: chemotherapy|DRUG: axitinib|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lower-Limb Adventitial Infusion of DexaMethasone Via Bullfrog to Reduce Occurrence of Restenosis After Percutaneous Transluminal Angioplasty Revascularization
Status: UNKNOWN
Conditions: Chronic Limb Ischemia
Interventions: DRUG: Dexamethasone sodium phosphate injection, USP, 4 mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: "Safeguard Your Smile" an Oral Health Literacy Intervention Promoting Positive Oral Hygiene Self-care Behavior
Status: COMPLETED
Conditions: Gingivitis|Dental Plaque
Interventions: BEHAVIORAL: Safeguard Your Smile an oral health literacy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Bendamustine Combined With Bortezomib for Patients With Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: bendamustine|DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma Multiforme in First Relapse
Status: WITHDRAWN
Conditions: Adult Brain Glioblastoma|Recurrent Adult Brain Neoplasm
Interventions: PROCEDURE: Electric Field Therapy|BIOLOGICAL: Bevacizumab|DRUG: Carmustine|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Investigational Drug in Patients With Osteoarthritis (0663-073)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: MK0663, etoricoxib|DRUG: Comparators: ibuprofen and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Translational Manipulation Under Interscalene Block for Adhesive Capsulitis of the Shoulder (TMACS)
Status: COMPLETED
Conditions: Shoulder Adhesive Capsulitis|Frozen Shoulder|Adhesive Capsulitis of Shoulder
Interventions: PROCEDURE: Translational manipulation|PROCEDURE: Manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peer Approaches to Lupus Self-management
Status: ACTIVE_NOT_RECRUITING
Conditions: Systemic Lupus Erythematosus|Quality of Life|Behavior, Health
Interventions: BEHAVIORAL: Peer Mentoring|BEHAVIORAL: Social Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Open, Non-comparative Study of the Efficacy and Safety of Treatment of Acne Scars With Restylane Vital Lidocaine
Status: COMPLETED
Conditions: Acne Scars
Interventions: DEVICE: Restylane Vital Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Deruxtecan(T-DXd) and Afatinib Combination in HER2-low Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Stomach Neoplasm
Interventions: DRUG: Trastuzumab deruxtecan|DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated.
Status: RECRUITING
Conditions: Autophagy|Galectins|HIV Infections|Highly Active Antiretroviral Therapy
Interventions: BIOLOGICAL: expression of a panel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP)
Status: TERMINATED
Conditions: Social Phobia
Interventions: DRUG: Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photoprotection Efficacy With Sunscreen Formulas Containing the Cyclic Merocyanine Long-UVA Absorber MCE, Under Real Sun Exposure
Status: UNKNOWN
Conditions: Real Life Pigmentation
Interventions: OTHER: cyclic merocyanine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial Evaluating Stereotactic Body Radiotherapy With Integrated Boost for Clinically Localized Prostate Cancer (RAD 1203)
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Radiation Toxicity|Sexual Dysfunction
Interventions: RADIATION: Stereotactic Body Radiation Therapy with Integrated Boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OBSiDiAN in a Stapled Circular Esophagogastric Anastomosis After Ivor Lewis Esophagectomy
Status: WITHDRAWN
Conditions: Anastomotic Leak Esophagus
Interventions: DEVICE: Obsidian
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study in Patients With Advanced Non-Small Cell Lung Cancer Using New Agents With and Without Docetaxel.
Status: WITHDRAWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: docetaxel|DRUG: CP-868,596 + docetaxel|DRUG: AG-013736 + docetaxel|DRUG: CP-868,596 + AG-013736 + docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib for the Treatment of Leiomyosarcoma
Status: WITHDRAWN
Conditions: Locally Advanced Leiomyosarcoma|Metastatic Leiomyosarcoma|Stage III Retroperitoneal Sarcoma AJCC v8|Stage IIIA Retroperitoneal Sarcoma AJCC v8|Stage IIIB Retroperitoneal Sarcoma AJCC v8|Stage IV Retroperitoneal Sarcoma AJCC v8|Unresectable Leiomyosarcoma
Interventions: DRUG: Niraparib Tosylate Monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PF-04634817 Renal Impairment Study
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: PF-04634817|DRUG: PF-04634817|DRUG: PF-04634817|DRUG: PF-04634817
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: First in Human Study of the Infusion of ARI0003 Cells in Relapsed/Refractory to Treatment B-cell Aggressive Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Refractory Non-Hodgkin Lymphoma|Relapsed Non-Hodgkin Lymphoma
Interventions: GENETIC: ARI0003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy
Status: UNKNOWN
Conditions: Surgical Wound Infection|Thyroid Nodule
Interventions: DRUG: Amoxicillin Clavulanate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Related Study on Surgical Treatment of Knee Joint Meniscus Injury
Status: UNKNOWN
Conditions: Meniscus Injury
Interventions: PROCEDURE: Meniscus Suture|PROCEDURE: Partial meniscus resection|PROCEDURE: Subtotal meniscus resection|PROCEDURE: Complete meniscectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tel-Me-Box: Testing a New, Real-time Strategies for Monitoring HIV Medication Adherence in India
Status: COMPLETED
Conditions: HIV|Medication Adherence
Interventions: BEHAVIORAL: Tel-me-box with reminder features|BEHAVIORAL: Tel-me-box
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1
Status: COMPLETED
Conditions: Heroin Dependence|Morphine Dependence|Substance Withdrawal Syndrome
Interventions: DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Amnestic Mild Cognitive Disorder|Deep Brain Stimulation|Mild Alzheimer's Disease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases
Status: UNKNOWN
Conditions: Purpura, Schoenlein-Henoch|Graft Versus Host Disease|Anemia, Hemolytic, Autoimmune|Rheumatoid Arthritis|Churg-Strauss Syndrome|Hypersensitivity Vasculitis|Wegener's Granulomatosis|Systemic Lupus Erythematosus|Giant Cell Arteritis|Pure Red Cell Aplasia|Juvenile Rheumatoid Arthritis|Polyarteritis Nodosa|Autoimmune Thrombocytopenic Purpura|Takayasu Arteritis
Interventions: DRUG: anti-thymocyte globulin|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: filgrastim|DRUG: methylprednisolone|DRUG: prednisone|PROCEDURE: Autologous Peripheral Blood Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Plus Chemoprotection With Amifostine in Treating Patients With Recurrent or Refractory Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: amifostine trihydrate|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Mild Sedation and Analgesia on Radial Artery Cannulation in Novice Operators
Status: RECRUITING
Conditions: Sedation and Analgesia
Interventions: DRUG: mild sedation and analgesia|DRUG: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotic-Associated Diarrhea and the Role of Microorganisms in the Gut
Status: COMPLETED
Conditions: Antibiotic-associated Diarrhea
Interventions: DRUG: Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Advancing Diabetes Management in Adolescents Using Health Information Technology
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: HIT-aided approach|BEHAVIORAL: Contracted conflict management system|BEHAVIORAL: HIT plus contracted conflict management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Prospective Multicenter Pivotal Study to Evaluate Safety and Effectiveness of Venus-Neo Surgical Aortic Valve
Status: NOT_YET_RECRUITING
Conditions: Aortic Valve Disease|Cardiovascular Diseases
Interventions: DEVICE: Venus-Neo Surgical Aortic Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure (APAP) on Resistant Hypertension (HTN) and Arterial Stiffness
Status: UNKNOWN
Conditions: Resistant Hypertension|Obstructive Sleep Apnea
Interventions: DEVICE: CPAP|DEVICE: APAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of multımedıa-based educatıon ın dıstance learnıng on nursıng Students'
Status: COMPLETED
Conditions: Nursing Students
Interventions: BEHAVIORAL: A randomızed Controlled Study with pre-test and post-test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PS-341 and Doxorubicin in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bortezomib|DRUG: doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant PNG Women
Status: UNKNOWN
Conditions: Pregnancy|Infections, Plasmodia|Drug Kinetics|Clinical Efficacy
Interventions: DRUG: Azithromycin plus piperaquine phosphate|DRUG: Sulfadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate The Effects of Two Different Meal Types, Omeprazole And Ranitidine On Danoprevir Pharmacokinetics When Coadministered With Ritonavir in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: danoprevir|DRUG: omeprazole|DRUG: ranitidine|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-PSMA-1007 PET/CT in Prostate Cancer - Access Trial 2022 to 2028
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: 18F-PSMA-1007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: AZD2066|DRUG: Placebo|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy of Pain Reduction With Cryoneurolysis Compared With Sham-treatment in Adults With Trigeminal Neuralgia
Status: RECRUITING
Conditions: Trigeminal Neuralgia
Interventions: DEVICE: Cryoneurolysis|DEVICE: Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dichotic Listening as a Predictor of Medication Response in Depression
Status: COMPLETED
Conditions: Major Depressive Disorder|Dysthymia
Interventions: DRUG: escitalopram|DRUG: bupropion|DRUG: imipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Travoprost 3-Month Safety and Efficacy Study
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost ophthalmic solution, 0.003%|DRUG: Travoprost ophthalmic solution, 0.004%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Gluconate Versus Povidone-iodine
Status: UNKNOWN
Conditions: Vaginal Flora Imbalance
Interventions: OTHER: Chlorhexidine Gluconate|OTHER: Povidone-iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Diagnosis of Viral Acute Respiratory Infection to Decrease Unnecessary Antibiotic Utilization in the Emergency Department (RADIATE)
Status: RECRUITING
Conditions: Acute Respiratory Infection|Viral Infection|Upper Respiratory Tract Infections
Interventions: DEVICE: SPOTFIRE R Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pre-emptive Daratumumab Therapy of Minimal Residual Disease Reappearance or Biochemical Relapse in Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab 20 MG/ML [Darzalex]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An In Vivo 24-Hour Recovery Study of Leukoreduced RBCs After Automated Separation of Whole Blood by the Reveos System and Storage for 42 Days
Status: COMPLETED
Conditions: Device Validation of In-vivo Performance
Interventions: DEVICE: Reveos® Automated Blood Processing System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Telemonitoring in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DEVICE: Health Buddy system|DEVICE: Telemonitoring in patients with heart failure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans
Status: RECRUITING
Conditions: Obesity|Hypertension|Circadian Dysregulation|Salt; Excess
Interventions: OTHER: Oral sodium supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of the Erchonia® LunulaLaser™ for the Treatment of Toenail Onychomycosis
Status: RECRUITING
Conditions: Onychomycosis of Toenail
Interventions: DEVICE: Erchonia LunulaLaser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet Monitoring vs Medication to Control Blood Sugar in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Internet-Based Glucose Monitoring System|DRUG: Normal Medication Positive Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Community Wise: An Innovative Multi-level Intervention to Reduce Alcohol and Illegal Drug Use
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Critical Dialogue|BEHAVIORAL: Capacity Building Project|BEHAVIORAL: Quality of Life Wheel|BEHAVIORAL: PF|BEHAVIORAL: LC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flexible Laryngeal Mask Airway Versus Tracheal Intubation in Nasal Bone Fracture
Status: COMPLETED
Conditions: Laryngeal Mask Airway
Interventions: DEVICE: Laryngeal mask airway|DEVICE: Endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: APN401 in Treating Patients With Melanoma, Kidney Cancer, Pancreatic Cancer, or Other Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Recurrent Melanoma|Recurrent Pancreatic Cancer|Recurrent Renal Cell Cancer|Stage III Pancreatic Cancer|Stage III Renal Cell Cancer|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma|Stage IV Pancreatic Cancer|Stage IV Renal Cell Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: siRNA-transfected peripheral blood mononuclear cells APN401|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Males to Assess Bioavailability of 4 Different Fostamatinib Tablets
Status: COMPLETED
Conditions: Bioavailability|Pharmacokinetics
Interventions: DRUG: Fostamatinib|DRUG: Fostamatinib|DRUG: Fostamatinib|DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase II Trial Measuring the Integration of Stereotactic Radiotherapy Plus Surgery in Early Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: RADIATION: Stereotactic Body Radiation Therapy plus Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Evaluation of Trimbow in Critically Ill Patients Admitted in ICU Compared to Standard of Care
Status: UNKNOWN
Conditions: COPD Exacerbation
Interventions: DRUG: TRIMBOW® pressurised inhalation solution: Beclometasone dipropionate / formoterol fumarate /glycopyrronium 87/5/9 µg per inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: D Mannose in Recurrent Urinary Tract Infections
Status: COMPLETED
Conditions: Recurrent Urinary Tract Infection
Interventions: DIETARY_SUPPLEMENT: D Mannose|DRUG: trimethoprim/sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF : Double Blinded, Randomized Control Trial
Status: NOT_YET_RECRUITING
Conditions: Spinal Stenosis Lumbar|Disc Degeneration|Disc Disease|Fusion of Spine|Surgery
Interventions: DRUG: Dexamethasone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Retreatment With Brentuximab Vedotin in Subjects With Classic Hodgkin Lymphoma or CD30-expressing Peripheral T Cell Lymphoma
Status: TERMINATED
Conditions: Hodgkin Lymphoma|Peripheral T Cell Lymphoma|Anaplastic Large Cell Lymphoma
Interventions: DRUG: brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Star Excursion Balance for Patellofemoral Pain Syndrome
Status: UNKNOWN
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Star excursion balance test|OTHER: Kinesthetic Ability Trainer 2000|OTHER: SEBT and KAT 2000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regorafenib Plus Pembrolizumab in Patients With Advanced or Spreading Liver Cancer Who Have Been Previously Treated With PD-1/PD-L1 Immune Checkpoint Inhibitors
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-warmed Intravenous Fluids and Monitored Anesthesia Care
Status: COMPLETED
Conditions: Hypothermia
Interventions: OTHER: Pre-warmed fluids|OTHER: Room temperature fluids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cabozantinib for Patients With Hepatocellular Carcinoma (HCC) Refractory to First Line Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable|Metastatic Hepatocellular Carcinoma
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients
Status: COMPLETED
Conditions: Duodenal Ulcer
Interventions: DRUG: 5 mg ilaprazole|DRUG: 10 mg ilaprazole|DRUG: 10 mg Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levosimendan Versus Combination With Magnesium Sulphate on Spine Protection by NIRS in Infants Undergoing Coarctectomy
Status: COMPLETED
Conditions: Aortic Coarctation
Interventions: DRUG: Saline Solution|DRUG: Levosimendan|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Research Study in Healthy Volunteers of Patients With Fanconi Anemia, Myeloproliferative Disorders, or Myeloma
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Fanconi Anemia|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: GENETIC: microarray analysis|GENETIC: polyacrylamide gel electrophoresis|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|GENETIC: western blotting|OTHER: chromatography|OTHER: high performance liquid chromatography|OTHER: immunoenzyme technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NeuroControl of Nicotine Dependence
Status: NOT_YET_RECRUITING
Conditions: Nicotine Dependence
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances
Status: TERMINATED
Conditions: Malocclusion
Interventions: DEVICE: Fixed Appliance Orthodontic Treatment|DEVICE: OrthoPulse™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examination of the Safety and Tolerability of NNC 0070-0002-0349 in Overweight/Obese Volunteers
Status: WITHDRAWN
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC 0070-0002-0349|DRUG: NNC 0070-0002-0349|DRUG: NNC 0070-0002-0349|DRUG: NNC 0070-0002-0349|DRUG: NNC 0070-0002-0349|DRUG: placebo|DRUG: placebo|DRUG: placebo|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits
Status: COMPLETED
Conditions: Irreversible Pulpitis|Pain
Interventions: DRUG: 4% articaine with 1:100,000 epinephrine|DRUG: 2% lidocaine with 1:100,000 epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-arm, Single Center Phase 1b Trial of Bavituximab Plus Ipilimumab in Advanced Melanoma Patients
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Arm A-Bavituximab 3mg/kg IV over 90 minutes weekly x 3 followed by Bavituximab 3mg/kg IV over 90 minutes weekly x 12 plus ipilimumab 3mg/kg IV|DRUG: Arm B-Ipilimumab 3mg/kg IV over 90 minutes day 1 followed three weeks later by ipilimumab every 3 weeks x 3.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Regional Distribution of Ventilation During Labor With or Without Epidural Analgesia
Status: COMPLETED
Conditions: Pregnancy|Atelectasis
Interventions: DRUG: Epidural analgesia Ropivacaine|DRUG: Absence of epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Limiting Chemotherapy Side Effects by Using Moxa
Status: UNKNOWN
Conditions: Breast Neoplasms|Colorectal Neoplasms|Genital Neoplasms, Female|Toxicity Due to Chemotherapy
Interventions: OTHER: Moxibustion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Removal Time of Urinary Catheter After Laparoscopic Anterior Resection of the Rectum
Status: UNKNOWN
Conditions: Rectum Cancer
Interventions: PROCEDURE: Early removal group|PROCEDURE: Normal removal group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SUCTIONING AT BIRTH WITH BULB SYRINGE OR SUCTION CATHETER: A RANDOMIZED CONTROLLED TRIAL
Status: COMPLETED
Conditions: Neonatal Resuscitation
Interventions: DEVICE: Bulb syringe|DEVICE: Suction catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Green Tea Catechins in Men on Active Surveillance
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma
Interventions: DRUG: Sunphenon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: GDC-0084|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Alphanate FVIII/VWF Concentrate in Type 3 Von Willebrand Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Von Willebrand Disease
Interventions: BIOLOGICAL: Alphanate SD/HT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Pilot Study of Apixaban for the Prevention of Thromboembolic Events in Patients With Advanced (Metastatic) Cancer
Status: COMPLETED
Conditions: Thrombosis|Cancer|Pulmonary Embolism
Interventions: DRUG: Apixaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study on the Effect of Telerehabilitation Using Wearable Devices After ACL Reconstruction
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Reconstruction
Interventions: BEHAVIORAL: the traditional rehabilitation group|DEVICE: the remote rehabilitation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of CD 2027 Spray in Subjects With Plaque-type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CD 2027|DRUG: Calcitriol Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: MAGSTIM Rapid2 TMS system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: MK6186 in HIV-1 Infected Patients (MK-6186-007 AM2)
Status: TERMINATED
Conditions: HIV-1 Infection
Interventions: DRUG: MK6186|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Docetaxel in Combination With Capecitabine in Stomach and Esophagus Cancers
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Docetaxel|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Hematologic Response Rate (the Rate at Which the Hemoglobin Level Rises) of PROCRIT (Epoetin Alfa) Given at a Dose of 80,000 Units Once Weekly to Cancer Patients With Anemia Who Are Receiving Chemotherapy.
Status: COMPLETED
Conditions: Anemia|Cancer|Chemotherapy
Interventions: DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Treatment of Refractory Breast Cancer Based on Organoid Drug Sensitivity Results
Status: NOT_YET_RECRUITING
Conditions: Refractory Breast Cancer
Interventions: OTHER: Chemotherapy and targeted-therapy guided by organoid drug sensitivity test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot Assisted Laparoscopic Hysterectomy vs. Abdominal Hysterectomy in Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: PROCEDURE: Abdominal total hysterectomy|PROCEDURE: Robot assisted laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacodynamics and Pharmacokinetics After Single Oral Administration of Dabigatran Etexilate Capsule in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate low dose|DRUG: Dabigatran etexilate medium dose|DRUG: Dabigatran etexilate high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures
Status: UNKNOWN
Conditions: Bimalleolar Ankle Fractures
Interventions: DEVICE: Active Combined Magnetic Field OL1000 Bone Growth Stimulator|DEVICE: Sham Combined Magnetic Field OL1000 Bone Growth Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Can a Flavonoid-rich Pure Cocoa Reduce Fatigue in People With Parkinson's (PD)
Status: COMPLETED
Conditions: Parkinson Disease|Fatigue
Interventions: DIETARY_SUPPLEMENT: Cocoa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nitazoxanide Compared to Placebo in Subjects With HBeAG-Negative Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Placebo Oral Tablet|DRUG: Nitazoxanide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: Neuroblastoma Vaccine (unmodified SKNLP, with gene-modified SJNB-JF-IL2 and SJNB-JF-LTN neuroblastoma cells|DRUG: Cytoxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Fenofibrate and Niacin in Patients With Hypertriglyceridemia and Low High-Density Lipoprotein (HDL)-Cholesterol
Status: COMPLETED
Conditions: Hypertriglyceridemia With Low HDL-cholesterol
Interventions: DRUG: lipid modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma (ALCL 99)
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: therapeutic hydrocortisone|DRUG: vinblastine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Nasotracheal Intubation With VL vs DL in Infants Trial
Status: RECRUITING
Conditions: Intubation Complication|Intubation; Difficult or Failed|Hypoxia|Hypoxemia|Anesthesia Intubation Complication|Pediatric HD
Interventions: DEVICE: Nasotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Novel Pharmacological Therapy for Obstructive Sleep Apnea
Status: RECRUITING
Conditions: Sleep Apnea
Interventions: DRUG: Atomoxetine|DRUG: Oxybutynin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Bearing Exercise in Preventing Frailty in Stage I-IIIA Breast Cancer Survivors
Status: COMPLETED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Cancer Survivor|Overweight|Postmenopausal|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8
Interventions: BEHAVIORAL: Exercise Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nodes-sparing Short-course Radiation Combined With CAPOX and Tislelizumab for MSS Middle and Low Rectal Cancer
Status: RECRUITING
Conditions: Low Rectal Cancer
Interventions: RADIATION: Modified short-course radiotherapy|DRUG: PD-1 antibody|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT