pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Assess the Efficacy, Safety and Tolerability of Pregabalin in Patients With Symptoms of Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Uncontrolled Advanced Glaucoma With Prior Failed Trabeculectomy or Tube Shunt
Status: UNKNOWN
Conditions: Advanced Glaucoma
Interventions: DRUG: Rho-Kinase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Physical Activity and Abstain From Smoking on the Precancerous Lesion
Status: UNKNOWN
Conditions: Cancer Cervix Uterus|Precancerous Lesions|Smoking
Interventions: BEHAVIORAL: Physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Endoscopic Epidural Neuroplasty and Percutaneous Epidural Neuroplasty in Low Back and Radicular Pain
Status: COMPLETED
Conditions: Low Back Pain|Radiculopathy
Interventions: PROCEDURE: Endoscopic epidural neuroplasty|PROCEDURE: Percutaneous epidural neuroplasty (PEN)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SWOG 8897-A DNA Analysis in Predicting Treatment Outcome in Women With Breast Cancer in SWOG 8897
Status: COMPLETED
Conditions: Breast Cancer
Interventions: GENETIC: mutation analysis|GENETIC: polymorphism analysis|OTHER: surface-enhanced laser desorption/ionization-time of flight mass spectrometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adult Bipolar Mania
Status: COMPLETED
Conditions: Acute Mania
Interventions: DRUG: Quetiapine fumarate XR|DRUG: Lithium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Licorice Versus Sugar-water Gargling for Pain in Patients Recovering From Ear-Nose-Throat and Maxilla-Facial Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Surgery, Oral
Interventions: OTHER: Licorice|OTHER: Sugar water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Secondary Cardiovascular Prevention Post-acute Myocardial Infarction (AMI) Through a Web-based Empowerment Program
Status: RECRUITING
Conditions: Acute Myocardial Infarction
Interventions: BEHAVIORAL: Digital empowerment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of a 4-phasic Oral Contraceptive for the Treatment of Heavy Menstrual Bleeding
Status: COMPLETED
Conditions: Metrorrhagia
Interventions: DRUG: EV/DNG (Qlaira, Natazia, BAY86-5027)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Fenebrutinib|DRUG: Teriflunomide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ventilation Strategy Reduces Postoperative Atelectasis
Status: WITHDRAWN
Conditions: Pulmonary Atelectasis
Interventions: PROCEDURE: No CPAP/PEEP and 100 % oxygen|PROCEDURE: CPAP/PEEP and 30 % oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 2
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Follitropin Delta (FE 999049)|DRUG: Follitropin Alfa (GONAL-F)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Dose Escalation Study of VX-993 in Healthy Participants
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: VX-993|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The FreMRI Study: Advanced MRI on Migraine Patients Treated With Fremanezumab
Status: RECRUITING
Conditions: Migraine Disorders|Migraine With Aura|Migraine Without Aura|Brain Diseases
Interventions: DRUG: Fremanezumab Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-Piece Zirconia Dental Implant vs Two-Piece Titanium Dental Implant- Randomized Clinical Control Trial
Status: UNKNOWN
Conditions: Osseointegration Failure of Dental Implant Due to Infection|Osseointegration Failure of Dental Implant Prior to Intentional Prosthetic Loading
Interventions: DEVICE: Dental Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of BIBR 953 ZW After Administration of BIBR 1048 MS in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 1048 MS Capsule I|DRUG: BIBR 1048 MS Capsule K|DRUG: Pantoprazole|DRUG: BIBR 1048 MS drinking solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid to Reduce Contraceptive-related Bleeding Side Effects
Status: RECRUITING
Conditions: Bleeding|Contraceptive Device; Complications
Interventions: DRUG: Tranexamic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regulatory Post-Marketing Surveillance Study for TETRAXIM™
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Poliomyelitis
Interventions: BIOLOGICAL: TETRAXIM™: Combined adsorbed diphtheria, tetanus, acellular pertussis and enhanced inactivated polio
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Peer-mentored Cooking Classes for Parents of Toddlers: Do Families Cook More and Eat Healthier After the Intervention?
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Peer mentoring intervention ('Cooking with Friends')
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Micro-doses of Physical Activity for COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Endothelial Dysfunction|Vascular Stiffness|Hypertension|Cardiovascular Diseases
Interventions: BEHAVIORAL: Microdoses of activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The SUSTAIN 2 Study - SUStained HIV Treatment for Adherence After Interruption in Care
Status: NOT_YET_RECRUITING
Conditions: Human Immunodeficiency Virus
Interventions: BEHAVIORAL: SUSTAIN-DSD|OTHER: Enhanced (guideline-driven) Standard of Care (E-SoC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Dietary Modifacation on Microbiota in Overweight and Obese Polycystic Ovary Syndrome Patients
Status: UNKNOWN
Conditions: PCOS
Interventions: DIETARY_SUPPLEMENT: Dietary and life style modification and probiotic Sanprobi Super Formula|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, PK and PD of AP303 in Healthy Chinese Participants
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: AP303 150 μg|DRUG: Placebo 150 μg|DRUG: AP303 300 μg|DRUG: Placebo 300 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous ETX2514 Administered in Healthy Subjects
Status: COMPLETED
Conditions: Acinetobacter Baumannii Infection
Interventions: DRUG: ETX2514|DRUG: Placebo|DRUG: Sulbactam|DRUG: Imipenem/Cilastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PF-06804103 Dose Escalation in HER2 Positive and Negative (Negative Only in Part 2) Solid Tumors
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: PF-06804103|DRUG: PF-06804103 + Palbociclib +Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in Giant Cells Arteritis
Status: TERMINATED
Conditions: Giant Cells Arteritis
Interventions: BEHAVIORAL: Clinical evaluation|OTHER: Paraclinical evaluation|DEVICE: Imaging|OTHER: Ophthalmologic examination|BIOLOGICAL: Dosage of biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions
Status: COMPLETED
Conditions: Metformin|Organic Cation Transporter 1|Codeine
Interventions: DRUG: Oral metformin|DRUG: Intravenous metformin|DRUG: Oral codeine and oral metformin|DRUG: Oral codeine and intravenous metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Utilizing Exhaled Breathe Condensate Collection to Study Ion Regulation in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Healthy
Interventions: DRUG: Albuterol|DRUG: Placebo saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Flap Advancement Techniques in Ridge Augmentation
Status: COMPLETED
Conditions: Flap Advancement|Primary Wound Closure
Interventions: PROCEDURE: coronally advanced lingual flap|PROCEDURE: periosteal releasing incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Palliative Transfusions on Quality of Life in Patients With Blood Cancers on Hospice
Status: COMPLETED
Conditions: Hematologic Malignancy
Interventions: PROCEDURE: Blood and/or platelet transfusion|PROCEDURE: Complete blood count (CBC) collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Selective Rather Than Routine Histopathological Examination Following Appendectomy and Cholecystectomy
Status: COMPLETED
Conditions: Appendix|Appendectomy|Appendiceal Neoplasms|Gallbladder|Cholecystectomy|Gallbladder Neoplasms
Interventions: OTHER: Inspection and palpation of the appendix|OTHER: Inspection and palpation of the gallbladder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhanced Problem-Solving Training
Status: COMPLETED
Conditions: Brain Concussion
Interventions: BEHAVIORAL: Enhanced Problem-Solving Training (E-PST)|BEHAVIORAL: Healthy Living Messages (HLM)|BEHAVIORAL: Enhanced Problem-Solving Training (E-PST) (non-randomized)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Substance P on Perception of Breathlessness During Resistive Load Breathing
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: aprepitant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Clinical Study of MeRes100 Sirolimus Eluting Bioresorbable Vascular Scaffold System
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: MeRes100 Sirolimus Eluting Bioresorbable Vascular Scaffold System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effect of Botulinum Toxin in Extensor Digitorum Brevis Via Strain Gauge and Nerve Conduction Studies
Status: COMPLETED
Conditions: Muscle Strength|Botulinum Toxins, Type A
Interventions: DRUG: Botulinum Toxin, Type A|DRUG: Botulinum Toxin, Type A|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: BONDIR Study: A Study of Intravenous Bonviva (Ibandronate) After Recent Vertebral Osteoporotic Fracture in Patients With Osteoporosis.
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Placebo|DRUG: ibandronate [Bonviva/Boniva]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%
Status: UNKNOWN
Conditions: Chlorhexidine|Ventilator Associated Pneumonia
Interventions: DRUG: Chlorhexidine gluconate at 2%|DRUG: Chlorhexidine gluconate at 0.12%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study of Rosuvastatin and AT-527 (R07496998)
Status: COMPLETED
Conditions: Healthy Volunteer Study
Interventions: DRUG: Drug: AT-527 + rosuvastatin|DRUG: AT-527 + rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food as Medicine for HIV and Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|HIV Infections|PreDiabetes
Interventions: BEHAVIORAL: MTM + ILI|BEHAVIORAL: Standard MTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Verteporfin Added to Ranibizumab in the Treatment of Symptomatic Macular Polypoidal Choroidal Vasculopathy
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: Verteporfin Photodynamic Therapy|DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Phase II Double-Blind Exploratory Study to Evaluate Differences Among Various Zidovudine/Didanosine Regimens on Quantitative Measures of Viral Burden in Relatively Early HIV-1 Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Surgery Versus Sclerotherapy for Isolated Accessory Great Saphenous Vein Varicosis
Status: COMPLETED
Conditions: Varicose Veins
Interventions: PROCEDURE: surgery|DRUG: sclerotherapy with aethoxysclerol foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Metformin|DRUG: Letrozole|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Imiquimod in Treating Patients With Recurrent Paget's Disease of the Vulva
Status: COMPLETED
Conditions: Vulvar Cancer
Interventions: DRUG: imiquimod|PROCEDURE: biopsy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab, Rituximab, Gemcitabine and Oxaliplatin in Patients With Relapsed or Refractory DLBCL Not Suitable for High-dose Therapy
Status: TERMINATED
Conditions: Diffuse Large B Cell Lymphoma|Relapsed Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Atezolizumab|DRUG: Rituximab|DRUG: Gemcitabine 1000 mg|DRUG: Oxaliplatin 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Value of 18F-Choline PET/CT in Patients With a Thyroid Nodule With an Indeterminate Cytology: Pilot Study
Status: COMPLETED
Conditions: Thyroid Gland
Interventions: DEVICE: Radiation : PET-CT with F18-choline examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hepatitis B Vaccine Booster Study (V232-058)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Comparator: Modified Process Hepatitis B Vaccine|BIOLOGICAL: Comparator: Comparator: ENGERIX-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Motor and Premotor Cortex Stimulation for Treatment of Secondary Focal Dystonia With Striato Palliadal Lesion : Evaluation of Safety and Effectiveness
Status: COMPLETED
Conditions: Focal Dystonia
Interventions: DEVICE: Implantation of neurostimulators and their auxiliary components
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Infusions of Stem Cells in the Treatment of COVID-19 Patients
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: BIOLOGICAL: Intravenous Infusions of Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Angel® Catheter Pivotal Clinical Trial
Status: COMPLETED
Conditions: Pulmonary Embolism|Deep Vein Thrombosis|Venous Thromboembolism|Trauma
Interventions: DEVICE: The Angel® Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis (RA) Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDs
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety of Extended Treatment With Pegsunercept (PEG sTNF-RI)in Subjects With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Pegsunercept (PEG sTNF-RI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Invigor Toric 1-Day Contact Lenses
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: 1-day toric test contact lens|DEVICE: 1-day toric control contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Compared With No Treatment Following Surgery in Treating Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: etoposide|DRUG: vinblastine sulfate|DRUG: vindesine|DRUG: vinorelbine tartrate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Bimatoprost Monotherapy vs. Dual Therapy With Travoprost and Timolol in Patients With Glaucoma and Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Bimatoprost 0.03%, Travoprost 0.004%, Timolol 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose:
Clinical trial: Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery
Status: COMPLETED
Conditions: Surgery|Coronary Artery Disease
Interventions: DRUG: Rocuronium|DRUG: Neostigmine|DRUG: Glycopyrrolate|DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combined Radiotherapy and Radiofrequency Ablation for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: Radiofrequency ablation|DEVICE: IMRT & SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PHARMACODYNAMICS ASSESSMENT PRODUCT HEPARIN SODIUM (INTRAVENOUSLY) OF THE SWINE 5.000UI/ML OF BLAU FARMACÊUTICA S/A IN HEALTHY SUBJECTS IN COMPARISON OF SODIUM HEPARIN APP PHARMACEUTICALS
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Nerve Block, Periarticular Nerve Group (PENG) Block, and Preoperative IV Fentanyl
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Femoral nerve block with0.25% bupivacaine guided by ultrasound.|DRUG: PENG block with0.25% bupivacaine guided by ultrasound.|DRUG: Preoperative IV fentanyl 100microgram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Portland Cement in Primary Anterior Teeth Pulpotomy.
Status: COMPLETED
Conditions: Pulpotomies
Interventions: OTHER: Pulpotomy therapy by White Portland Cement|OTHER: Pulpotomy therapy by White MTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Stress Reduction and Lifestyle Modification for Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: BEHAVIORAL: lifestyle-modification|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zanubrutinib and Venetoclax as Initial Therapy for Chronic Lymphocytic Leukemia (CLL) With Response-based Obinutuzumab
Status: RECRUITING
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: Zanubrutinib Pill|DRUG: Venetoclax Pill|DRUG: Obinutuzumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Afatinib After Chemoradiation and Surgery in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck at High-Risk of Recurrence
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: afatinib|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NMDA Receptor Modulation for the Treatment of Bipolar I Disorder
Status: RECRUITING
Conditions: Bipolar I Disorder
Interventions: DRUG: NMDAE|DRUG: Placebo Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Pharmacokinetic Study of LEO 29102 in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: LEO 29102 cream|DRUG: LEO 29102 placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Scapular Stabilization Program in Patients Chronic Non-specific Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Relaxation Exercises and Scapular Stabilization exercise program|OTHER: Relaxation Exercises of cervico- scapular region
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Body Vibration and Unstable Shoes on Balance in Healthy Young People
Status: COMPLETED
Conditions: Balance
Interventions: OTHER: Unstable shoes plus Whole-body vibration|OTHER: Stable shoes plus Whole-body vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Surgery or Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Maximum Tolerated Dose, Safety and Pharmacologic Study of TRF in Women With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer Female
Interventions: DIETARY_SUPPLEMENT: Tocotrienol-rich Fraction (TRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Tocotrienols in CADASIL
Status: UNKNOWN
Conditions: Cadasil
Interventions: DRUG: HOV-12020 (Palm tocotrienols complex)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization
Status: UNKNOWN
Conditions: Liver and Intrahepatic Bile Duct Carcinoma
Interventions: RADIATION: Computed Tomography Perfusion Imaging|PROCEDURE: Liver Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Adaptive SBRT Plus Chemoimmunotherapy for ES-SCLC
Status: RECRUITING
Conditions: Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: Durvalumab 50 MG/1 ML Intravenous Solution|DRUG: Etoposide Injection|DRUG: Cisplatin|DRUG: Carboplatin|DEVICE: Stereotactic Body Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: B-cryptoxanthin and Phytosterols on Bone Remodeling and Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Postmenopausal Disorder
Interventions: DIETARY_SUPPLEMENT: b-cryptoxanthin and phytosterols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Airtime Incentive Amounts to Improve Interactive Voice Response Surveys in Bangladesh and Uganda
Status: COMPLETED
Conditions: Surveys and Questionnaires|Noncommunicable Diseases
Interventions: OTHER: 1X airtime incentive|OTHER: 2X airtime incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Sit Less, Interact, Move More (SLIMM) Intervention for Sedentary Behavior in Chronic Kidney Disease (CKD)
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: BEHAVIORAL: Sit Less, Interact, Move More (SLIMM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Italian Study of the Efficacy of Atomoxetine in the Treatment of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) and Comorbid Oppositional Defiant Disorder (ODD).
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Oppositional Defiant Disorder
Interventions: DRUG: atomoxetine 0.5 mg/kg/day|DRUG: placebo|DRUG: atomoxetine 1.2 mg/kg/day|DRUG: atomoxetine 1.2-1.4 mg/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Inflammatory Challenge Using Endotoxin
Status: COMPLETED
Conditions: Alcohol Use Disorder|Inflammatory Response|Craving|Depressed Mood
Interventions: DRUG: Placebo|BIOLOGICAL: Endotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Purpose of This Study is to Determine if Tetrodotoxin (TTX) is Effective in the Treatment of Pain Resulting From Chemotherapy Treatment
Status: TERMINATED
Conditions: Pain|Peripheral Neuropathy|Neuropathic Pain
Interventions: DRUG: Placebo|DRUG: Tetrodotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kefir Versus Milk on Time-Trial Performance in Masters Athletes
Status: COMPLETED
Conditions: Gastrointestinal Complication|Exercise Performance|Aerobic Endurance
Interventions: OTHER: Water|OTHER: Flavored Kefir|OTHER: Flavored Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI
Status: RECRUITING
Conditions: Stroke|Intracranial Atherosclerosis
Interventions: DRUG: Ferumoxytol Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ventilatory Strategy for the Prevention of Atelectasis During Bronchoscopy Under General Anesthesia, VESPA Trial
Status: COMPLETED
Conditions: Lung Disorder
Interventions: PROCEDURE: Anesthesia Procedure|PROCEDURE: Anesthesia Procedure|PROCEDURE: Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block.
Status: COMPLETED
Conditions: Hallux Valgus|Surgery
Interventions: DEVICE: Virtual reality|DRUG: Droleptan|DRUG: Propofol|DRUG: Sufentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mantram Repetition Meditation for Veterans With PTSD
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: Mantram Repetition Program (MRP)|BEHAVIORAL: Present Centered Therapy (PCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Indacaterol Maleate (QAB149) as a New Formulation in the EPIC Test Fixture
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: QAB149 75 mg Concept 1|DRUG: QAB149 75 mg Epic Test Fixture|OTHER: Placebo Concept 1|OTHER: Placebo EPIC Test Fixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Difluprednate in the Treatment of Inflammation Following Ocular Surgery (ST-601A-002a)
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: Difluprednate|DRUG: Difluprednate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Romiplostim Treatment of Thrombocytopenia in Subjects With Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: MDS|Myelodysplastic Syndromes|Thrombocytopenia
Interventions: DRUG: Placebo|BIOLOGICAL: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prophylactic Negative Wound Therapy in Laparotomy Wounds.
Status: UNKNOWN
Conditions: Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay
Interventions: DEVICE: Smith & Nephew PICO Negative wound pressure versus standard dresing|DEVICE: PREVENA Negative pressure wound versus standard dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Variability of Physical Assessments in an Older Population That is Overweight or Obese
Status: COMPLETED
Conditions: Obesity|Aging
Interventions: BEHAVIORAL: Short Performance Physical Battery (SPPB Test)|BEHAVIORAL: 30 Second Chair Stand Test (30CST)|BEHAVIORAL: Hand grip dynamometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liver MRI With Primovist/Eovist in Pediatric Subjects Who Are Suspected or Have Focal Liver Lesions.
Status: COMPLETED
Conditions: Liver Neoplasms|Adenoma|Carcinoma|Liver Abscess
Interventions: DRUG: Gadoxetic Acid Disodium (Eovist, BAY86-4873)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: Suspension of human autologous MSC 3P in 1.5 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Short-message-based Re-education (SMRE) on Helicobacter Pylori Eradication
Status: UNKNOWN
Conditions: Helicobacter Pylori Eradication Rate
Interventions: BEHAVIORAL: Short-message-based Re-education|BEHAVIORAL: conventional education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids
Status: TERMINATED
Conditions: Uterine Fibroids
Interventions: DRUG: Vilaprisan (BAY1002670)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness Research to Enhance Outcomes in African-Americans With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Portable monitoring|OTHER: Polysomnography|DEVICE: Home portable monitoring|DEVICE: Laboratory portable monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lactulose for the Prevention of Hepatic Encephalopathy in Cirrhotic Patients With Upper Gastrointestinal Hemorrhage
Status: UNKNOWN
Conditions: Hepatocerebral Encephalopathy|Portal-Systemic Encephalopathy|Encephalopathy, Hepatic|Encephalopathy, Hepatocerebral
Interventions: DRUG: Lactulose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity
Status: TERMINATED
Conditions: Adenotonsillectomy|Analgesia|Surgery
Interventions: DRUG: Dexamethasone|DRUG: Ibuprofen|DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma
Status: RECRUITING
Conditions: Advanced Renal Cell Carcinoma
Interventions: BIOLOGICAL: MEDI5752|DRUG: Axitinib|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of a New Device for Real-Time Muscle Pressure Measurements in Patients at Risk for Acute Compartment Syndrome
Status: COMPLETED
Conditions: Compartment Syndrome Traumatic Lower Extremity|Compartment Syndrome Traumatic Upper Extremity
Interventions: DEVICE: MY01 Continuous Compartmental Pressure Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Safety and Pharmacokinetics of KSP-1007 Alone and Coadministered With Meropenem in Healthy Subjects
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: KSP-1007|OTHER: Placebo:0.9% sodium chloride|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effects of Isoflavone and Estrogen in Sex Response in Climacteric Women
Status: UNKNOWN
Conditions: Postmenopausal Symptoms
Interventions: DRUG: estradiol|DRUG: isoflavone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Epilepsy After Traumatic Brain Injury With Topiramate
Status: TERMINATED
Conditions: Traumatic Brain Injury|Epilepsy
Interventions: DRUG: topiramate|DRUG: topiramate|DRUG: phenytoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intracoronary Abciximab With Clearway Catheter
Status: TERMINATED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Intracoronary bolus wtih ClearWay™RX catheter|DRUG: IV abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Study to Assess the V Needle in End-Stage Renal Disease Patients During In-Clinic Hemodialysis
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: V Needle AV Fistula Set
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: THE TRAVEL II TRIAL: Transcatheter Right Atrial-ventricular Valve rEplacement With LuX-Valve Via Jugular Vein
Status: RECRUITING
Conditions: Tricuspid Valve Regurgitation
Interventions: DEVICE: Tricuspid Valve Replacement System via jugular vein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the BIOTRONIK AutoAdapt Algorithm for Continuous Automatic Adaptive Cardiac Resynchronization
Status: RECRUITING
Conditions: Heart Failure|Cardiac Arrhythmia|Left Ventricular Dysfunction
Interventions: PROCEDURE: Echo-based assessment of the acute hemodynamic effect of the CRT AutoAdapt feature.|PROCEDURE: Echocardiography AV optimization|PROCEDURE: Echocardiography|OTHER: Self Assessment Score
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multifaceted Intervention Using Telehealth to Reduce the Risk of Falls and Fractures in Older Men
Status: RECRUITING
Conditions: Osteoporosis|Osteoporotic Fractures|Osteoporosis, Age-Related|Muscle Loss|Men|Aging
Interventions: BEHAVIORAL: Multifaceted Virtual Fracture Prevention Program|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture and Relaxation Response for GI Symptoms and HIV Medication Adherence
Status: COMPLETED
Conditions: HIV Infections
Interventions: PROCEDURE: Acupuncture|BEHAVIORAL: Relaxation Response|OTHER: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Intravaginal Treatment With Carboxymethyl-β-glucan and Polycarbophil in HR-HPV Clearance
Status: UNKNOWN
Conditions: Human Papilloma Virus
Interventions: DEVICE: Colpofix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Neuromodulation|Neurogenic Bladder|Neurogenic Bowel|Neurogenic Detrusor Overactivity
Interventions: DEVICE: Epidural Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics (PK), Pharmacodynamics(PD), Safety, Tolerability of SR1375 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SR1375 capsules|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Pharmacodynamic Study of Bococizumab Alone and When Combined With Recombinant Human Hyaluronidase
Status: TERMINATED
Conditions: Healthy|Hypercholesterolemia
Interventions: BIOLOGICAL: Cohort 1: bococizumab 150 mg + rHuPH20|BIOLOGICAL: Cohort 2: bococizumab 300 mg|BIOLOGICAL: Cohort 3: bococizumab 300 mg + rHuPH20|BIOLOGICAL: Cohort 5: bococizumab 450 mg + rHuPH20|BIOLOGICAL: Cohort 4: bococizumab 300 mg + rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety and Efficacy Study of Oral Dimebon in Patients With Mild-To-Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Dimebon|DRUG: Dimebon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial Using the Health TAPESTRY Approach to Care for Older Adults
Status: COMPLETED
Conditions: Aging
Interventions: OTHER: Health TAPESTRY Intervention|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chronic Pain Self-management for Older Adults With Cognitive Impairment: A Randomized Pilot Trial
Status: RECRUITING
Conditions: Chronic Pain|Cognitive Impairment
Interventions: BEHAVIORAL: STEPS-CI (Support, Training, and Education for Pain Self-management- Cognitively Inclusive version)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electromyographic Biofeedback on Quadriceps Neuromuscular Function in Patients With Quadriceps Inhibition
Status: TERMINATED
Conditions: Knee Injuries
Interventions: DEVICE: Electromyographic Biofeedback|BEHAVIORAL: Traditional Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 64Cu-DOTA-U3-1287 in Subjects With Advanced Solid Tumors
Status: TERMINATED
Conditions: Carcinoma|Sarcoma|Lymphoma
Interventions: DRUG: 64Cu-DOTA-U3-1287|DRUG: U3-1287 (unlabeled)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy of an Experimental Dissolvable Strip in Rapidly Relieving Dentinal Hypersensitivity (DH)
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Dissolvable polymer strip containing Novamin (calcium sodium phosphosilicate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of LBM and PPIs on Pharmacokinetics and Safety of Regorafenib (BAY 73-4506) in Cancer Patients
Status: WITHDRAWN
Conditions: Metastatic Solid Malignancies|Locally Advanced Solid Malignancies
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab in Treating Patients With Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelofibrosis
Status: WITHDRAWN
Conditions: Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase|Primary Myelofibrosis
Interventions: BIOLOGICAL: Durvalumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT