pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: 18F-florbetaben PET-CT to Non-invasively Diagnose Cardiac AL Amyloidosis
Status: RECRUITING
Conditions: Amyloid|Amyloid Cardiomyopathy
Interventions: DIAGNOSTIC_TEST: 18F-florbetaben PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intercalated Combination of Chemotherapy and Tyrosine Kinase Inhibitors as First-line Treatment for Patients With Non-Small-Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Gefitinib|DRUG: Icotinib|DRUG: Docetaxel|DRUG: Pemetrexed|DRUG: Platinum (cisplatin or carboplatin)|DRUG: Erlotinib|DRUG: Gefitinib|DRUG: Icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Steroid Formulation and Wet Wraps
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: 0.1% triamcinolone CREAM|DRUG: 0.1% triamcinolone OINTMENT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation and Acceptance and Commitment Therapy
Status: RECRUITING
Conditions: Chronic Pain|Depression
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation|BEHAVIORAL: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: abSorbable vErsus Non-absorbable SuturEs for Wound Closure in Carpal Tunnel Release
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome|Wound Infection|Suture, Complication
Interventions: PROCEDURE: Carpal Tunnel Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T790M Plasma Testing Methodology Comparison and Clinical Validation
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: T790M+ Testing|PROCEDURE: Baseline Visit Blood & Urine Testing|PROCEDURE: Baseline ECG|PROCEDURE: Visual Slit-Lamp Testing|DRUG: AZD9291 Dosing|PROCEDURE: Plasma AZD9291 testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I/II Study of Linperlisib Plus Chidamide for R/R Peripheral T-cell Lymphoma: a Prospective, Multi-center Study
Status: RECRUITING
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: Linperlisib in combined with Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis
Status: UNKNOWN
Conditions: Deep Venous Thrombosis
Interventions: PROCEDURE: Percutaneous mechanical thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of VG161 Combined With Camrelizumab in Patients With Advanced Primary Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Primary Hepatocellular Carcinoma
Interventions: DRUG: Recombinant Human IL12/15-PDL1B Oncolytic HSV-1 Injection (Vero Cell))|DRUG: camrelizumab for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
Status: COMPLETED
Conditions: Locally Advanced Malignant Neoplasm|Breast Cancer
Interventions: DRUG: Propranolol|OTHER: DOT imaging|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Doxorubicin|DRUG: Cyclophosphamide|PROCEDURE: Surgery|DRUG: Premedication|DRUG: Anti-nausea therapy|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Non-vascular ICD Electrode Configuration Feasibility Study
Status: COMPLETED
Conditions: Ventricular Arrythmia
Interventions: PROCEDURE: Temporary implantation of defibrillation coils and pulse generator|PROCEDURE: Defibrillation following induction of VA (Configuration A first)|PROCEDURE: Defibrillation following induction of VA (Configuration B first)|PROCEDURE: Removal of defibrillation coils and pulse generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Lenvatinib Combined With Chinese Herbal Medicine for Patients With Unresectable Hepatocellular Carcinoma: A Real-world Study in China
Status: COMPLETED
Conditions: Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Chinese Herbal Medicine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Caring for the Caregiver Network
Status: COMPLETED
Conditions: Caregivers of Alzheimer's Disease or Memory Problem Patients
Interventions: BEHAVIORAL: Caregiving condition|BEHAVIORAL: Nutrition condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy and Radiation Therapy With/Without Surgery In Patients With Stage II/III Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|DRUG: paclitaxel|RADIATION: radiation therapy|DRUG: Gemcitabine|PROCEDURE: Radical cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence/Food Effect - Saxa/Dapa Dual Fixed Dose Combination (FDC)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Saxagliptin|DRUG: Dapagliflozin|DRUG: Saxagliptin/Dapagliflozin FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III)
Status: RECRUITING
Conditions: Prosthesis and Implants|Surgical Site Infection|Prosthetic Joint Infection|Postoperative Wound Infection Deep Incisional Surgical Site
Interventions: DRUG: Photodynamic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vitamin D and Chronic Obstructive Lung Disease
Status: WITHDRAWN
Conditions: Chronic Obstructive Lung Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D (D3, cholecalciferol)|DIETARY_SUPPLEMENT: Placebo (cellulose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autonomic Dysfunction in Functional Dysphonia
Status: RECRUITING
Conditions: Functional Voice Disorder|Psychogenic Voice Disorder|Muscle Tension Dysphonia
Interventions: BEHAVIORAL: ANS regulation therapy|BEHAVIORAL: conventional voice therapy (CVT)|BEHAVIORAL: ANS regulation therapy + CVT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TENS for Relief of Postoperative Pain in Orthopedic Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Orthopedic Disorder|Post Operative Pain|Hip Fractures|Hip Osteoarthritis
Interventions: DEVICE: transcutaneous electrical nerve stimulation (TENS)|DEVICE: Sham transcutaneous electrical nerve stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients
Status: RECRUITING
Conditions: Cutibacterium Acnes Infection
Interventions: DRUG: 5% benzoyl peroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BDB001-101: Clinical Study of BDB001 as a Mono-therapy or in Combination With Pembrolizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Tumor, Solid
Interventions: DRUG: BDB001|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate the Effect on Corrected QT Interval Prolongation by Psychotropic Drugs
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Escitalopram|DRUG: Quetiapine|DRUG: Moxifloxacin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)
Status: COMPLETED
Conditions: Oxytocin Deficiency|Hypopituitarism|Hypothalamic Obesity|Pituitary Dysfunction|Central Diabetes Insipidus|Social Isolation
Interventions: DIETARY_SUPPLEMENT: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Functional Outcomes in COVID-19 Survivors and Use of a Digital Platform for Rehabilitation
Status: COMPLETED
Conditions: COVID-19|Coronavirus Infections|Exercise Therapy
Interventions: OTHER: Rehabilitation protocol through a digital platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Novel Post-Surgical Incision Management to Prevent Ostomy Complications
Status: NOT_YET_RECRUITING
Conditions: Ostomy|Enterocutaneous Fistula
Interventions: DEVICE: Limpet|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells
Status: RECRUITING
Conditions: CMV Infection|Cytomegalovirus Infections|CMV Viremia|Opportunistic Infections
Interventions: BIOLOGICAL: CMV-specific T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiotherapy vs Intensity-modulated Radiotherapy in Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: IMRT|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pilot Study to Treat Patients With Chronic Hepatitis C Virus (HCV) Genotype 1 and End-Stage Renal Disease (ESRD)
Status: UNKNOWN
Conditions: Chronic Hepatitis C|End Stage Renal Disease
Interventions: DRUG: Ribavirin|DRUG: Peginterferon|DRUG: Boceprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brace Monitoring for Adolescent Idiopathic Scoliosis (AIS)
Status: RECRUITING
Conditions: Adolescent Idiopathic Scoliosis
Interventions: DEVICE: Cinch Smart Strap|OTHER: Cinch Mobile App
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study Investigating the Excretion Balance, Pharmacokinetics and Metabolism of a Single Oral Dose of [14C]-Labeled Risdiplam (RO7034067) in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [^14C]-Risdiplam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Weight Loss on Cardiovascular Disease Risk Factors in Obese Women
Status: COMPLETED
Conditions: Obesity|Cardiovascular Diseases
Interventions: BEHAVIORAL: Diet|BEHAVIORAL: Diet Plus Aerobic Training|BEHAVIORAL: Diet plus Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)
Status: RECRUITING
Conditions: Lymphoma, Large B-Cell, Diffuse (DLBCL)
Interventions: BIOLOGICAL: Zilovertamab Vedotin|DRUG: Cyclophosphamide|DRUG: Doxorubicin|BIOLOGICAL: Rituximab|BIOLOGICAL: Rituximab Biosimilar|DRUG: Prednisone|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Acetaminophen in Craniotomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oropharyngeal Space in Videolaryngoscopy
Status: COMPLETED
Conditions: Abrasion of Soft Palate|Intubation Complication
Interventions: DEVICE: C-MAC ® videolaryngoscope|DEVICE: Coopdech® videolaryngoscope|DEVICE: McGrath® Series 5 videolaryngoscope|DEVICE: Glidescope® Cobalt videolaryngoscope|DEVICE: King Vision® videolaryngoscope|DEVICE: Venner® videolaryngoscope|DEVICE: McGrath® MAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Resminostat for Maintenance Treatment of Patients With Advanced Stage Mycosis Fungoides (MF) or Sézary Syndrome (SS)
Status: COMPLETED
Conditions: Mycosis Fungoides|Sezary Syndrome|Lymphoma, T-Cell, Cutaneous
Interventions: DRUG: resminostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting the Bipolar Care Model for Chronic Care Management in Community-based Health Care Sites
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Replicating Effective Programs Framework for the Bipolar Care Model|BEHAVIORAL: Bipolar Care Model Package Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Breast Ultrasound and Mammography in Screening Women at High Risk for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: breast imaging study|PROCEDURE: comparison of screening methods|PROCEDURE: magnetic resonance imaging|PROCEDURE: radiomammography|PROCEDURE: ultrasound imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SCREENING
Clinical trial: Effectiveness Trial of Temperament Based Therapy With Support (TBT-S)
Status: NOT_YET_RECRUITING
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Temperament Based Therapy with Support (TBT-S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Financial Incentives to Increase Colorectal Cancer Screening in Priority Populations
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Auto Mailing Plus Money|BEHAVIORAL: Auto Mailing Plus Lottery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Evaluation of Tabalumab Using Auto-Injector or Prefilled Syringe in Participants With Rheumatoid Arthritis (RA)
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tabalumab Auto-Injector|DRUG: Tabalumab Prefilled Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Efficacy and Safety of Levofloxacin vs Isoniazid in Latent Tuberculosis Infection in Liver Transplant Patients".
Status: TERMINATED
Conditions: Latent Tuberculosis Infection|Infection in Solid Organ Transplant Recipients
Interventions: DRUG: Levofloxacin|DRUG: Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manipulating Linguistic Complexity to Improve Child Language Treatment Outcomes
Status: COMPLETED
Conditions: Language Development Disorders|Speech Sound Disorder
Interventions: BEHAVIORAL: Phonological treatment|BEHAVIORAL: Morpheme treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease
Status: RECRUITING
Conditions: Autoimmune Inner Ear Disease|Meniere's Disease
Interventions: DRUG: Anakinra 100Mg/0.67Ml Inj Syringe (Period 1)|DRUG: Placebo injection (Period 1)|DRUG: Anakinra 100Mg/0.67Ml Inj Syringe (Period 2)|DRUG: Placebo injection (Period 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT- Comparing Testimonial Versus Documentary Organ Donation Video Education
Status: COMPLETED
Conditions: Organ Donation
Interventions: BEHAVIORAL: Control ending - Uplifting|BEHAVIORAL: Negative Consequences Ending|BEHAVIORAL: Unresolved Ending
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity
Status: COMPLETED
Conditions: Xerostomia|Depression|Hypertension
Interventions: DRUG: Malic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Specific IgG Antibody in Patients With Primary Antibody Deficiencies Treated With Subcutaneous Immunoglobulin
Status: COMPLETED
Conditions: Common Variable Immunodeficiency|Agammaglobulinemia
Interventions: BIOLOGICAL: gammaglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive|Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome|Small Airway Disease|Quality of Life
Interventions: DRUG: Budesonide(160ug) and Formoterol(4.5ug) bid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Postoperative Bracing Necessary After Spine Surgery for Degenerative Conditions
Status: COMPLETED
Conditions: Degenerative Lumbar Spinal Stenosis|Lumbarsacral Orthosis|Transforaminal Lumbar Interbody Fusion
Interventions: DEVICE: Knight-Taylor [chairback] brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-Center, Randomized Controlled Clinical Investigation Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System in the Healing of Diabetic Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: SyntrFuge System|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of IFX-1 to Replace Steroids in Patients With Granulomatosis With Polyangiitis and Microscopic Polyangiitis.
Status: COMPLETED
Conditions: Granulomatosis With Polyangiitis (GPA)|Microscopic Polyangiitis (MPA)
Interventions: DRUG: IFX-1|DRUG: Placebo-IFX-1|DRUG: Glucocorticoid (GC)|DRUG: Placebo-Glucocorticoid (Placebo-GC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Graft Versus Host Disease
Interventions: DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Behavioral Training on Physiological Responses to Smoking Cues, Affect and Cortisol
Status: COMPLETED
Conditions: Smokers
Interventions: BEHAVIORAL: Mindfulness behavioral intervention (MT),cognitive behavioral intervention (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II CT-2103/Carboplatin in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasm
Interventions: DRUG: CT-2103 (poly(L)glutamate-paclitaxel)|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Convalescent Plasma in the Treatment of Covid-19
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: Convalescent plasma from COVID-19 donors|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imagery Rescripting as a Stand-alone Treatment for OCD and BDD.
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|Body Dysmorphic Disorders|Anxiety Disorders
Interventions: BEHAVIORAL: Imagery rescripting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5407 in Adult Participants18 Years of Age and Older
Status: COMPLETED
Conditions: Influenza Immunization
Interventions: BIOLOGICAL: Quadrivalent Influenza mRNA Vaccine MRT5407|BIOLOGICAL: Quadrivalent Recombinant Influenza Vaccine|BIOLOGICAL: Quadrivalent Influenza Standard Dose Vaccine|BIOLOGICAL: Quadrivalent Influenza High-Dose Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Light Therapy and Electrical Stimulation on Functional Performance in Volleyball Athletes
Status: COMPLETED
Conditions: Muscle Weakness|Sports Performance
Interventions: OTHER: Exercise|OTHER: LASER|OTHER: NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Prospective Randomized Clinical Trial for Effect of Stellate Ganglion Block in Medically Refractory Ventricular Tachycardia
Status: UNKNOWN
Conditions: Refractory Ventricular Tachycardia
Interventions: DRUG: Antiarrhythmic drug|PROCEDURE: percutaneous stellate ganglion block (PSGB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Training in Patients With Rheumatoid Arthritis and Cryotherapy
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: OTHER: constant exercise|OTHER: cryotherapy|OTHER: intermittent exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms, Gastrointestinal Tract
Interventions: DRUG: Lapatinib|DRUG: Placebo|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Normal and Impaired Walking in Children Using the GAITRite Walkway
Status: COMPLETED
Conditions: Typically Developing Children|Talipes Equino Varus|Paediatric Orthopaedic|Paediatric Neurological
Interventions: DEVICE: Gait assessment using the GAITRIte walkway
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Post Isometric Relaxation and Post Facilitation Stretching on Hamstring Muscle Flexibility
Status: COMPLETED
Conditions: Hamstring Injury
Interventions: OTHER: Post isometric relaxation|OTHER: Post facilitation stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Puppet Show on Pain and Fear During Subcutaneous Injection in Children With Leukemia
Status: RECRUITING
Conditions: Pain, Acute|Fear
Interventions: BEHAVIORAL: puppet show
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Investigation of Effectiveness of a Calcium Silicate Cement
Status: RECRUITING
Conditions: Deep Caries|Dentin Caries
Interventions: DEVICE: Theracal (calcium silicate)|DEVICE: Dycal (calcium hydroxide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of UCB3101 in Healthy Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: UCB3101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sport-specific Endurance Training on Cardiorespiratory Fitness
Status: RECRUITING
Conditions: Cardiorespiratory Fitness
Interventions: OTHER: Warm Up Exercises|OTHER: Endurance Based Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Psychotherapy for Improving Quality of Life in Patients With Hypertrophic Cardiomyopathy and Depression
Status: UNKNOWN
Conditions: Hypertrophic Cardiomyopathy|Depression|Anxiety|Psychotherapy
Interventions: OTHER: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Effects of Three Iodinated Contrast Media (CM) in Patients at Risk Undergoing Coronary Angiography
Status: WITHDRAWN
Conditions: Coronary Artery Disease (CAD)|Renal Impairment|Diabetes Mellitus
Interventions: DRUG: Iodixanol, Ioversol, Iopromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prediction of Outcomes Following Total Knee Replacement- Pilot
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee|Knee Replacement
Interventions: BEHAVIORAL: Mindfulness-based Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer
Status: TERMINATED
Conditions: Advanced Cancer|Breast Cancer|Gastric Cancer|Esophageal Cancer|Colorectal Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Trastuzumab|DRUG: ado-trastuzumab emtansine|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Finding and Efficacy Study of Venetoclax, CC-486, and Obinutuzumab in Follicular Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Obinutuzumab|DRUG: CC-486
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Fludarabine monophosphate, melphalan, Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of UCT-01-097 in Participants With Advanced Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumor
Interventions: DRUG: UCT-01-097|DRUG: Gemcitabine|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes After PCI of the Aneurysmatic Right Coronary Artery
Status: RECRUITING
Conditions: Coronary Disease|Coronary Artery Ectasia|Right Coronary Artery Occlusion|Right Coronary Artery Stenosis|STEMI
Interventions: PROCEDURE: Percutaneous Coronary Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Catheter Ablation for Atrial Fibrillation in patientS With End-sTage Heart Failure and Eligibility for Heart Transplantation
Status: COMPLETED
Conditions: Heart Failure|Atrial Fibrillation
Interventions: PROCEDURE: Atrial fibrillation ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reactogenicity, Safety and Immunogenicity of a LAIV H7N9 Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: H7N9 live influenza vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lenalidomide and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: azacitidine|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Domiciliary Intervention by Occupational Therapy to Prevent Elderly Rehospitalization
Status: COMPLETED
Conditions: Rehospitalization
Interventions: OTHER: Domiciliary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief HIV Prevention Counseling for STI Patients in South Africa
Status: COMPLETED
Conditions: Sexually Transmitted Infections
Interventions: BEHAVIORAL: 60 Minute HIV/STI risk reduction counseling.Single 60 min Social Cognitive Theory-based counseling.|BEHAVIORAL: 20-Min education session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy, Weight Control, and Safety in Newly-diagnosed Type 2 Diabetes With Different Antidiabetic Therapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Triple combination therapy group|DRUG: Premixed insulin therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Can Child Health Services Identify and Respond to Family Violence
Status: COMPLETED
Conditions: Family Violence|Domestic Violence|Intimate-partner Violence
Interventions: PROCEDURE: Routine questions|PROCEDURE: Questions on evidence based indication|PROCEDURE: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Interactive Tablet Compared to Oral Midazolam as Premedication in Preoperative Anxiety in Children
Status: COMPLETED
Conditions: Anxiety
Interventions: PROCEDURE: elective surgery|DRUG: Midazolam|DEVICE: Interactive Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Versus Adjuvant Therapy in Treating Resectable Thoracic Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: OTHER: Neoadjuvant chemoradiotherapy|OTHER: Adjuvant chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steering Together in a New Direction: Reducing the Risk of HIV/STD Among African American Men
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)|Sexually Transmitted Disease (STD)
Interventions: BEHAVIORAL: STAND HIV Risk Reduction Intervention|BEHAVIORAL: Text Messaging Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium
Status: COMPLETED
Conditions: Gastric Ulcer
Interventions: DRUG: Esomeprazole Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Status: RECRUITING
Conditions: Chronic Sinusitis
Interventions: BIOLOGICAL: dupilumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Voice Analysis as a Measure of Frailty and Distress
Status: RECRUITING
Conditions: Frailty|Distress, Emotional
Interventions: OTHER: Data acquisition: Speech acquisition|DIAGNOSTIC_TEST: Data acquisition: G8 Screening tool|DIAGNOSTIC_TEST: Data acquisition: Distress Thermometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults.
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscle Atrophy|Aging|Energy Malnutrition Protein
Interventions: OTHER: Energy status
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Isthmus Ablation With Gold Electrode for Treatment of Atrial Flutter (AURUM 8)
Status: COMPLETED
Conditions: Atrial Flutter
Interventions: DEVICE: Gold tip catheter|DEVICE: Platinum-iridium tip catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Injection to Prevent Ventricular Arrhythmias
Status: UNKNOWN
Conditions: Symptomatic Ventricular Asystolia|Ventricular Tachycardia
Interventions: DRUG: Botulinum Toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Outcomes of Toric Intraocular Lens
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Precizon toric intraocular lens|DEVICE: Tecnis toric intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-term Safety and Performance of PanOptix Intraocular Lens (IOLs)
Status: RECRUITING
Conditions: Aphakia|Astigmatism|Presbyopia
Interventions: DEVICE: AcrySof IQ PanOptix IOL|DEVICE: AcrySof IQ PanOptix Toric IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Montelukast in Patients With Seasonal Allergic Rhinitis - Spring 2000 Study (MK-0476A-162)(COMPLETED)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Comparator: montelukast|DRUG: Comparator: loratadine|DRUG: Comparator: placebo|DRUG: Comparator: montelukast/loratadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketone Production With Acute Caffeine Intake
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Caffeine low dose|DIETARY_SUPPLEMENT: Caffeine high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of NovoMix® 30 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart|DRUG: biphasic human insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide
Status: COMPLETED
Conditions: Healthy Volunteers|Endotoxemia
Interventions: DRUG: Defibrotide|DRUG: Placebo (0.9% sodium chloride)|DRUG: Lipopolysaccharide|DRUG: Placebo (0.9% sodium chloride bolus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of Darunavir for the Treatment of HIV/AIDS
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: DRUG: Darunavir|DRUG: ART with 2 NRTIs plus LPV/r (or ATV/r)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trocar Site Incisional Hernia Prevention
Status: RECRUITING
Conditions: Incisional Hernia
Interventions: PROCEDURE: Hincisional hernia prevention by onlay prosthesis trocar closure|PROCEDURE: laparoscopic cholecystectomy|DIAGNOSTIC_TEST: Abdominal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Food on the Pharmacokinetics of Oral Treprostinil
Status: COMPLETED
Conditions: Hypertension, Pulmonary|Pulmonary Arterial Hypertension
Interventions: DRUG: Treprostinil diethanolamine|OTHER: Standardized meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Characterization of CD8+ T Cells After Supramaximal Exercise
Status: COMPLETED
Conditions: Exercise Induced CD8+ T Cell Recruitment and Characterization of Function and Phenotype of These Cells
Interventions: PROCEDURE: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Oral MD-0727 Administered to Patients With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MD-0727
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Decision-Making and Virtual Reality Exercise
Status: RECRUITING
Conditions: Degenerative Lumbar Spinal Stenosis|Degenerative Disc Disease|Degenerative Spondylolisthesis|Degenerative Intervertebral Discs
Interventions: OTHER: VR skateboarding training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Escitalopram in the Treatment of Dysthymic Disorder, Double Blind
Status: COMPLETED
Conditions: Dysthymic Disorder
Interventions: DRUG: Lexapro (escitalopram)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Safety, Tolerability and PK of KX-826 in Healthy Males With Alopecia Following Topical Multiple Dose Ascending
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: KX0826|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pilates Exercises on Diastasis Recti Abdominis in Postpartum Women
Status: COMPLETED
Conditions: Diastasis Recti
Interventions: OTHER: Abdominal belt|OTHER: Pilates exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects
Status: UNKNOWN
Conditions: Bypass Complications
Interventions: DRUG: Sustained release morphine sulfate, 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Type 2 Diabetes Mellitus Prevention Ukraine
Status: COMPLETED
Conditions: Impaired Fasting Glucose|Impaired Glucose Tolerance|Type 2 Diabetes
Interventions: OTHER: Physical activity|OTHER: Macronutrient modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study to Compare Capecitabine Combined With Dacarbazine(CAPDTIC) Versus Capecitabine Combined Temozolomide(CAPTEM) in Advanced and Metastatic Gastrointestinal Pancreatic and Esophageal Neuroendocrine Tumor
Status: UNKNOWN
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Capecitabine, Dacarbazine|DRUG: Capecitabine, Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REmotely Monitored, Mobile Health-Supported High Intensity Interval Training After COVID-19 Critical Illness (REMM-HIIT-COVID-19)
Status: COMPLETED
Conditions: Covid19|Critical Illness|High Intensity Interval Training|ICU|Intensive Care Units|Fitness Trackers
Interventions: BEHAVIORAL: REmotely Monitored, Mhealth (REMM) supported High Intensity Interval Training (HIIT)|OTHER: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Infertility|Menopausal Symptoms
Interventions: DRUG: cyclophosphamide|DRUG: goserelin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of a Risk Stratification Tool on the Outcome of Liver Transplant Recipients Colonized With Carbapenem Resistant Enterobacteriaceae: an Observational Study
Status: RECRUITING
Conditions: Liver Transplantation|Carbapenem-Resistant Enterobacteriaceae Colonization
Interventions: OTHER: Application of a prognostic score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Fixed Dose Study of Adjunctive Treatment to Antidepressant Therapy for Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: LY2216684|DRUG: Placebo|DRUG: SSRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BMS-354825 in Patients With Chronic Accelerated, or Blast Phase Chronic Myelogenous Leukemia or Philadelphia Positive Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia, Myeloid, Chronic-phase|Leukemia, Lymphoblastic, Acute, Philadelphia-positive
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Passive Paracentesis for Intra-abdominal Hypertension
Status: UNKNOWN
Conditions: Ascites Hepatic|Cirrhosis, Liver|Hypertension, Intraabdominal|Critical Illness|Paracentesis
Interventions: DEVICE: continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter|PROCEDURE: Ultrasound-guided intermittent large-volume paracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MAD Study of SSGJ-613 in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Arthritis, Gouty
Interventions: DRUG: SSGJ-613|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Probiotic ES1 for the Treatment of Non-Celiac Gluten Sensitivity
Status: UNKNOWN
Conditions: Non-Celiac Gluten Sensitivity
Interventions: OTHER: Probiotic ES1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention and Decolonization of Multidrug-resistant Bacteria With Probiotics
Status: UNKNOWN
Conditions: Probiotics|Enterobacteriaceae Infections
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Study of AO-176 as Monotherapy and in Combination With Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: AO-176|DRUG: AO-176 + Dex|DRUG: AO-176 + Dex + Bort
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT