pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trial of Eribulin/Cyclophosphamide or Docetaxel/Cyclophosphamide as Neoadjuvant Therapy in Locally Advanced HER2-Negative Breast Cancer
Status: COMPLETED
Conditions: HER2 Negative Breast Cancer
Interventions: DRUG: Eribulin|DRUG: Cyclophosphamide|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantifying Hepatic Mitochondrial Fluxes in Humans
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Type 2 Diabetes|Mitochondrial Metabolism Disorders
Interventions: DRUG: Pioglitazone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Liposomal Bupivacaine After Arthroscopic Rotator Cuff Repair
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: DRUG: Liposomal bupivacaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Structural and Functional Effects of High Intensity Training (HIT) Program in Patients With Non-specific Chronic Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: high intensity training (HIT) program|OTHER: moderate intensity training (MIT) exercise therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Task-oriented Activity Based Neurodevelopmental Principles and Gross Motor Task Training.
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Task-oriented activities based on NDT (TOA-NDT) principle and Conventional Physical Therapy|OTHER: Gross motor task training and Conventional physical therapy (CPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Lanabecestat in Participants With Severe Kidney Impairment Compared to Healthy Participants
Status: WITHDRAWN
Conditions: Renal Insufficiency
Interventions: DRUG: Lanabecestat|DRUG: Iohexol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Efficacy of Brachytherapy With or Without Hormone Therapy, Using Triptorelin 22.5mg in Patients With Recurrence of Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: Triptorelin 22.5 mg|RADIATION: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transperineal Laser Ablation for Low- and Intermediate Risk Prostate Cancer: a Single Cohort Analysis
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: Soractelite Echolaser Transperineal focal laser ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravitreal Ozurdex on DME After Cataract Surgery
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: dexamethasone intravitreal implant (OZURDEX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Everolimus and Pasireotide (SOM230) in Patients With Advanced or Metastatic Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Advanced Adult Hepatocellular Carcinoma
Interventions: DRUG: Everolimus|DRUG: Pasireotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions
Status: COMPLETED
Conditions: Effect of Irrigation Activation on Periapical Healing
Interventions: PROCEDURE: Manual dynamic activation|PROCEDURE: Passive ultrasonic activation|PROCEDURE: Laser activation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain Reduction in the Administration of Saline Injections by the Usage of Pneumatic Skin Flattening
Status: UNKNOWN
Conditions: Healthy
Interventions: PROCEDURE: Saline Injection|DEVICE: Pneumatic Skin Flattening (PSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
Status: RECRUITING
Conditions: Heart Failure NYHA Class II|Heart Failure NYHA Class III
Interventions: DEVICE: Cordella™ Pulmonary Artery Sensor System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Selecting Effective Combinations of Treatment for Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Lumbar medial branch nerve radiofrequency ablation (LRFA)|PROCEDURE: Simulated LRFA with targeted steroid injections|BEHAVIORAL: AcTIVE-CBT|BEHAVIORAL: TBSCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: UCLA Health Patient Health Maintenance Text Reminder July 2023
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Maintenance|Diabetes|Cancer
Interventions: BEHAVIORAL: Reminder of preventive care measures|BEHAVIORAL: Persuasion via anecdote|BEHAVIORAL: Persuasion via anecdote without link|BEHAVIORAL: Persuasion via research
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Liposomal Doxorubicin in Treating Patients With Stage IIB, Stage IVA, or Stage IVB Recurrent or Refractory Mycosis Fungoides
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Escalation Study in Participants With Recurrent Malignant Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioma
Interventions: DRUG: LY2157299|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Trial of Cannabidiol (CBD; GWP42003-P) for Infantile Spasms: Open-label Extension Phase (GWPCARE7)
Status: COMPLETED
Conditions: Infantile Spasms
Interventions: DRUG: GWP42003-P
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: Methotrexate|DRUG: csDMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Plecanatide Chronic Idiopathic Constipation (CIC) Study
Status: COMPLETED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: plecanatide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N2O for Acute Suicidality and Depression in the ED
Status: NOT_YET_RECRUITING
Conditions: Suicidal Ideation|Major Depressive Disorder|Treatment Resistant Depression
Interventions: DRUG: Nitrous oxide gas for inhalation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Mozambique
Status: COMPLETED
Conditions: Malaria
Interventions: OTHER: Standard LLIN|OTHER: Piperonyl butoxide ITN|OTHER: Pyriproxyfen ITN|OTHER: Chlorfenapyr ITN
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 2a Study of BIIB074 in the Treatment of Erythromelalgia
Status: COMPLETED
Conditions: Primary Inherited Erythromelalgia
Interventions: DRUG: BIIB074|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2605541|DRUG: Insulin Glargine|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: R-MINE+X in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Rituximab|DRUG: Mitoxantrone hydrochloride liposome|DRUG: Isophosphamide|DRUG: Etoposide|DRUG: X: Orelabrutinib|DRUG: X: Chidamide|DRUG: X: Penpulimab|DRUG: X: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Smoked THC and CBD in Men and Women
Status: RECRUITING
Conditions: Drug Abuse|Intoxication by Drug|Impairment
Interventions: DRUG: Placebo Cannabis|DRUG: 20 mg CBD Cannabis|DRUG: 20 mg CBD + 20 mg THC Cannabis|DRUG: 20 mg THC Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Intratumoral Injection of Gene Therapy for Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma
Interventions: DRUG: Gene Therapy product CYL-02|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Examine the Effects of MultiStem in Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: MultiStem|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of PH-797804 on QTc Interval
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PH-797804|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Short Course Radiotherapy Followed Intensive Chemotherapy With Delayed Surgery for Rectal Cancer With Synchronous Distant Metastasis
Status: UNKNOWN
Conditions: Rectal Cancer|Liver Metastasis|Lung Metastasis
Interventions: RADIATION: Short Course Radiotherapy|DRUG: Chemotherapy|PROCEDURE: Delayed Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
Status: COMPLETED
Conditions: ADHD|Opioid-Related Disorders|Cocaine Dependence
Interventions: DRUG: Methylphenidate|DRUG: Bupropion|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose
Status: UNKNOWN
Conditions: Telangiectasia, Hereditary Hemorrhagic
Interventions: DRUG: bevacuzimab spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dosimetry Guided PRRT With 90Y-DOTATOC
Status: WITHDRAWN
Conditions: Neuroendrocrine Tumors|Meningioma|Neuroblastoma|Medulloblastoma
Interventions: RADIATION: 90Y-DOTA-3-tyr-Octreotide|PROCEDURE: Positron Emission Tomography (PET) whole body scan|DRUG: Amino Acids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ameliorating Cognitive Control in Binge Eating Disorder
Status: COMPLETED
Conditions: Binge-Eating Disorder
Interventions: OTHER: Behavioral training and verum stimulation|OTHER: Behavioral training and sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extended Treatment With Vancomycin for Clostridium Difficile Colitis
Status: WITHDRAWN
Conditions: Clostridium Difficile Colitis
Interventions: DRUG: Standard Vancomycin|DRUG: Extended Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAR3419 as Single Agent in Relapsed-Refractory Diffuse Large B-Cell Lymphoma (DLBCL) Patients
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: SAR3419
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Parathyroid Hormone (PTH) on Craniofacial Osseous Regeneration in Bone
Status: TERMINATED
Conditions: Implant
Interventions: DRUG: Teriparatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suture Reinforcement to Reduce the Leak Rate After Sleeve Gastrectomy
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Obesity, Morbid|Leak, Anastomotic|Bleeding
Interventions: PROCEDURE: laparoscopic sleeve gastrectomy without suture reinforcement|PROCEDURE: laparoscopic sleeve gastrectomy with suture reinforcement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of a Rehabilitation Program on Physical Performance and Disease Self-management in Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: experimental Fit-program|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fractional CO2 Laser Assisted Photodynamic Therapy
Status: COMPLETED
Conditions: Actinic Keratosis|Basal Cell Carcinoma
Interventions: DRUG: Conventional photodynamic therapy|DRUG: Fractional CO2 laser assisted PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Status in Infants in Ethiopia.
Status: UNKNOWN
Conditions: Iron-deficiency|Iron Deficiency Anemia|Aluminium Intoxication
Interventions: OTHER: Traditionally Threshed Teff (TTT)|OTHER: Lab Threshed Teff (LTT)|OTHER: Fortified Lab Threshed Teff (FTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Muscle, Essential Amino Acids, and eXercise in Heart Failure
Status: TERMINATED
Conditions: Heart Failure, Diastolic
Interventions: OTHER: Exercise|DIETARY_SUPPLEMENT: Essential Amino Acids|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: CPI-613 in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Small Cell Lung Cancer
Interventions: DRUG: 6,8-bis(benzylthio)octanoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study to Evaluate Safety, Tolerability and Pharmacokinetics of Various Doses of BCD-085 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: humanized monoclonal antibody against human IL-17
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)
Status: RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: OTHER: Placebo|DRUG: Cladribine Low Dose|DRUG: Cladribine High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multifunctional Nutrition Tube on Social Condition and Experience in Cerebralvascular Accident
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: comprehensive rehabilitation therapy|DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Displaced Supracondylar Fractures of the Humerus Using Lateral vs. Crossed K-wires
Status: COMPLETED
Conditions: Humeral Fractures
Interventions: PROCEDURE: Crossed K-wiring of supracondylar fracture of the humerus|PROCEDURE: Lateral K-wiring of supracondylar fracture of the humerus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) Versus Camrelizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation
Status: ACTIVE_NOT_RECRUITING
Conditions: Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation
Interventions: DRUG: Camrelizumab、Rivoceranib|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Flash Technique Via Self-Therapy App on Depression, Anxiety, and Traumatic Symptoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Traumatic Stress Disorder
Interventions: DEVICE: Self-Therapy Mobile App|OTHER: Psycho-education Videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effect of Simulated Live Piano Music on Preoperative Cancer Patients, Health Care Providers and Hospital Volunteers Using Validated Questionnaires and Proteomic Analysis
Status: WITHDRAWN
Conditions: Symptoms and Signs Involving Cognition Perception Emotion & Behaviour|Abdominal Cancer Patients
Interventions: BEHAVIORAL: Musical Intervention|PROCEDURE: Blood Draws|BEHAVIORAL: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: NestaCell® Mesenchymal Stem Cell to Treat Patients With Severe COVID-19 Pneumonia
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: BIOLOGICAL: NestaCell®|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Composite Flour and Its Antdiabetic Potential
Status: COMPLETED
Conditions: Blood Glucose, High|Body Weight Changes|Hyperlipidemias|Body Composition
Interventions: COMBINATION_PRODUCT: low GI composite flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Development of a Model for Digital Monitoring of the Mental State of the Hospitalized Patient
Status: RECRUITING
Conditions: Severe Mental Disorder|Schizophrenia|Personality Disorders|Mood Disorders|Bipolar Disorder|Depressive Disorder|Anxiety Disorders|Psychotic Episode|Schizoaffective Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SEMAGLUTIDE VERSUS GLP-1 RECEPTOR AGONISTS. EFFECTIVENESS , SAFETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS 2. OBSERVATIONAL, PROSPECTIVE AND MULTICENTER STUDY. SEVERAL STUDY.
Status: COMPLETED
Conditions: Weight Loss|Diabetes Mellitus, Type 2|Quality of Life|Safety Issues
Interventions: DRUG: GLP-1 receptor agonist
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effectiveness of Radial Shockwave Therapy on Myofascial Pain Syndrome in Neck and Upper Back.
Status: UNKNOWN
Conditions: Myofascial Pain Syndrome of Neck
Interventions: DEVICE: Radial shockwave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cosmetic Effects of Topical Acetyl Zingerone
Status: COMPLETED
Conditions: Wrinkle Appearance|Skin Pigment|Erythema|Side Effect|Microbiome|Lipidome
Interventions: OTHER: Acetyl Zingerone Topical Cream|OTHER: Topical cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Status: COMPLETED
Conditions: Cardiovascular Function|Genotoxicity
Interventions: OTHER: Electric train|OTHER: Diesel train
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Permanent Pacing for Drug-refractory Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy.
Status: RECRUITING
Conditions: Obstructive Hypertrophic Cardiomyopathy
Interventions: PROCEDURE: pace maker implant guided by acute hemodynamic testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seaweed-Derived Mineral-Rich Nutraceuticals in Cognition
Status: COMPLETED
Conditions: Cognition
Interventions: DIETARY_SUPPLEMENT: Aquamin/Aquamin MG|OTHER: Maltodextrin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(Alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis
Status: TERMINATED
Conditions: Axial Spondyloarthritis
Interventions: DRUG: Placebo|DRUG: Ustekinumab 45 mg|DRUG: Ustekinumab 90 mg|DRUG: Golimumab 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resynchronization in Patients With HF in AF Trial Undergoing Pace & AVNA Strategy With LBBAP Compared With BiV Pacing
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Heart Failure|Cardiomyopathies
Interventions: PROCEDURE: Left Bundle Branch Area Pacing|PROCEDURE: CRT|PROCEDURE: AV node ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Biliary Tract Carcinoma|Metastatic Colorectal Carcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Metastatic Malignant Digestive System Neoplasm|Metastatic Pancreatic Adenocarcinoma|Stage IV Colorectal Cancer AJCC v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7
Interventions: DRUG: Fluorouracil|DRUG: Irinotecan Sucrosofate|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Terlipressin Therapy in Acute Variceal Haemorrhage After EVL
Status: COMPLETED
Conditions: Acute Variceal Haemorrhage
Interventions: DRUG: Normal Saline|DRUG: Terlipressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Childhood Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: asparaginase (E. Coli)|DRUG: asparaginase (Erwina)|DRUG: dexrazoxane|DRUG: doxorubicin|PROCEDURE: cranial radiation (once daily fractionation)|PROCEDURE: cranial radiation (twice-daily fractionation)|PROCEDURE: Intrathecal chemotherapy without radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prostaglandins Versus Trans-cervical Balloon for Induction of Labor in Fetal Growth Restriction (PROBIN)
Status: RECRUITING
Conditions: Fetal Growth Restriction
Interventions: DEVICE: Trans-cervical balloon|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multi-Center Study of Phasix™ Mesh for Ventral or Incisional Hernia Repair.
Status: COMPLETED
Conditions: Ventral Hernia|Incisional Hernia
Interventions: DEVICE: Resorbable Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Promoting Informed Decision Making Through Advance Care Planning
Status: UNKNOWN
Conditions: Dementia|Neurodegenerative Diseases
Interventions: OTHER: 'Comfort Care at the End of Life for Persons with Dementia'|OTHER: Project Nurse - ACP Facilitator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Withdrawal of Inhaled Corticosteroids in Patients With COPD in Primary Care
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Fluticasone 500mcg BD via accuhaler or identical placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease
Status: RECRUITING
Conditions: Liver Diseases|Acute on Chronic Hepatic Failure
Interventions: OTHER: collection of liver biopsies collection of blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aortic or Mitral Valve Replacement With the Biocor and Biocor Supra
Status: COMPLETED
Conditions: Aortic Valve Insufficiency|Aortic Valve Regurgitation|Aortic Valve Stenosis|Aortic Valve Incompetence|Mitral Valve Insufficiency|Mitral Valve Regurgitation|Mitral Valve Stenosis|Mitral Valve Incompetence
Interventions: DEVICE: Biocor and Biocor Supra valves
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy
Status: COMPLETED
Conditions: Leber's Hereditary Optic Neuropathy
Interventions: DRUG: Idebenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy
Status: COMPLETED
Conditions: Periodontitis, Adult
Interventions: PROCEDURE: Minimally invasive non-surgical therapy|COMBINATION_PRODUCT: Subgingival application of collagen hydrogels with proanthocyanidins|DIAGNOSTIC_TEST: Collection of saliva samples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intraoperative Use of Dexmedetomidine During the Daytime Operation vs the Nighttime Operation on Postoperative Sleep Quality and Pain Under General Anesthesia
Status: UNKNOWN
Conditions: Postoperative Pain|Postoperative Sleep Quality|Intraoperative Dexmedetomidine|General Anesthesia
Interventions: OTHER: time of receiving operation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of REGN6569 and Cemiplimab in Adult Patients With Advanced Solid Tumor Malignancies
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: REGN6569|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Vortioxetine (Lu AA21004) for Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Vortioxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Complication Control in Community Clinics (D4C) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|Hypertension|Dyslipidemia|Cardiovascular Disease
Interventions: OTHER: Protocol-based integrated care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies
Status: RECRUITING
Conditions: Smoking Cessation|Smoking Cessation Intervention|Nicotine Addiction|Epigenetics|Molecular Biology|Genetic Epidemiology
Interventions: BEHAVIORAL: Flexiquit Smoking Cessation Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lenvatinib Plus HAIC of Modified FOLFOX Regime vs Lenvatinib Plus HAIC of ROX Regime in Patients With Advanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Stage IIIa
Interventions: DRUG: Lenvatinib|DRUG: mFOLFOX regimen|DRUG: ROX regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12)
Status: RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: mFOLFIRINOX-FOLFIRI intensified chemotherapy|DRUG: FOLFOX or CAPOX adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose, Dose-Ranging Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men
Status: UNKNOWN
Conditions: Healthy Men|Male Contraception
Interventions: DRUG: Placebo|DRUG: 11βmethyl nortestosterone dodecylcarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of CVGBM in Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma or Astrocytoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: BIOLOGICAL: CV09050101 mRNA vaccine (CVGBM) 12 μg|BIOLOGICAL: CV09050101 mRNA vaccine (CVGBM) 25 μg|BIOLOGICAL: CV09050101 mRNA vaccine (CVGBM) 50 μg|BIOLOGICAL: CV09050101 mRNA vaccine (CVGBM) 100 μg|BIOLOGICAL: CV09050101 mRNA vaccine RDE 100 μg|BIOLOGICAL: CV09050101 mRNA vaccine (CVGBM) 6 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK and Safety of SI-722 in IC/BPS
Status: COMPLETED
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: DRUG: SI-722|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Probiotics in the Eradication of Helicobacter Pylori
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Caps Lactolevure|DRUG: Caps Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BOTOX® in the Treatment of Crow's Feet Lines in China
Status: COMPLETED
Conditions: Lateral Canthal Lines|Crow's Feet Lines
Interventions: BIOLOGICAL: botulinum toxin Type A|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of BI 695502 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 695502|DRUG: bevacizumab|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effectiveness of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Adults 65 Years of Age and Older
Status: TERMINATED
Conditions: Influenza (Healthy Volunteers)
Interventions: BIOLOGICAL: Quadrivalent Influenza Vaccine (split virion, inactivated) High-Dose (QIV-HD)|BIOLOGICAL: Standard-Dose Inactivated Influenza Vaccine Quadrivalent, Northern Hemisphere strains (QIV-SD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EffiCacy and sAfEty of Low doSe orAl iRon for Anaemia in IBD
Status: RECRUITING
Conditions: Inflammatory Bowel Disease|Iron Deficiency Anemia
Interventions: DRUG: Ferrous fumarate syrup 2.5ml/70mg (22.5mg elemental iron)|DRUG: Ferrous fumarate syrup 2.5ml/70mg(45mg elemental iron)|DRUG: Ferrous fumarate syrup 2.5ml/70mg (90mg elemental iron)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Application in Subacromial Impingement Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Progressive Exercises|OTHER: Blood Flow Restriction Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)
Status: RECRUITING
Conditions: Childhood Acute Lymphoblastic Leukemia
Interventions: DRUG: Dexamethasone continuous|DRUG: Dexamethasone intermittent|DRUG: Dexamethasone|DRUG: Methylprednisolone|DRUG: Daunorubicin|DRUG: Idarubicin|DRUG: Bortezomib|DRUG: Second phase of induction|DRUG: Standard induction therapy|DRUG: Standard consolidation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Cisplatin, Plus Nivolumab in Patients With Muscle-invasive Bladder Cancer With Selective Bladder Sparing
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Nivolumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interaction of Alcohol With Energy Drinks
Status: COMPLETED
Conditions: Alcohol-Related Disorders|Drinking and Driving
Interventions: DIETARY_SUPPLEMENT: Alcohol and energy drink|DIETARY_SUPPLEMENT: Alcohol|DIETARY_SUPPLEMENT: Energy drink|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Ranging Study Comparing the Efficacy, Safety and Pharmacokinetics of Intravenous Infusions of ABT-874 vs Placebo in Subjects With Active Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: ABT-874|BIOLOGICAL: ABT-874
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Botulinum Toxin Injection Techniques in Spasticity
Status: NOT_YET_RECRUITING
Conditions: Spastic Hemiplegia
Interventions: DRUG: Onabotulinumtoxina for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Anesthesia With Hyperbaric Levobupivacaine 0.75% for Ambulatory Knee Arthroscopy
Status: COMPLETED
Conditions: Disorder of Knee|Anesthesia
Interventions: DRUG: Hyperbaric Levobupivacaine 0.75%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety of Cal-1 (LVsh5/C46) Drug Product in HIV-1 Infected Patient With High Risk Lymphoma
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Cal-1 (LVsh5/C46) drug product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Activity Study of PSCA-Targeted CAR-T Cells (BPX-601) in Subjects With Selected Advanced Solid Tumors
Status: SUSPENDED
Conditions: Metastatic Castration-resistant Prostate Cancer|Metastatic Prostate Cancer
Interventions: BIOLOGICAL: BPX-601|DRUG: Rimiducid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Artesunate-amodiaquine-methylene for Malaria Treatment in Children
Status: COMPLETED
Conditions: Uncomplicated Falciparum Malaria
Interventions: DRUG: artesunate (AS) - amodiaquine (AQ) - methylene blue (MB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Dapagliflozin Augment The Favorable Adaptation To Endurance Exercise Training?
Status: COMPLETED
Conditions: Physical Activity
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Trial of Avelumab-cetuximab-radiotherapy Versus SOCs in LA SCCHN (REACH)
Status: ACTIVE_NOT_RECRUITING
Conditions: HNSCC
Interventions: DRUG: Cetuximab|DRUG: avelumab|DRUG: Cisplatin|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Supplementary Effects of the Extract of Agaricus Blazei Murril on Type II Diabetes Mellitus (DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: Extract of Agaricus blazei Murill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study to Find Out the Appropriate Initial Dose of the Anticoagulant Drug Phenprocoumon
Status: COMPLETED
Conditions: Pulmonary Embolism|Atrial Fibrillation|Hip Replacement Postoperative|Knee Replacement Postoperative
Interventions: OTHER: Algorithm for phenprocoumon|OTHER: algorithm for phenprocoumon|DRUG: Phenprocoumon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Omega-3 FA on Glucose and Lipid Homeostasis Disorders in Obese/Diabetic Patients
Status: COMPLETED
Conditions: Hyperglycaemia (Diabetic)|Hyperlipidemias
Interventions: DRUG: Low dose omega-3 fatty acid supplementation|DRUG: High dose omega-3 fatty acid supplementation|DRUG: Control drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Sulopenem in Adolescents
Status: WITHDRAWN
Conditions: Urinary Tract Infections|Pyelonephritis Acute|Intraabdominal Infections
Interventions: DRUG: Sulopenem
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib in Treating Patients With Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: pazopanib hydrochloride|PROCEDURE: pharmacological study|PROCEDURE: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the PillCam™ Colon Capsule Endoscopy (PCCE) Night Procedure
Status: COMPLETED
Conditions: Colonic Diseases
Interventions: DEVICE: PillCam™ (Capsule Endoscopy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fractional CO2 Laser-assisted Cutaneous Delivery of Methotrexate Versus 5-fluorouracil in Stable Non-segmental Vitiligo
Status: UNKNOWN
Conditions: Vitiligo
Interventions: DRUG: Methotrexate|DRUG: 5-fluorouracil|DEVICE: Fractional CO2 laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Hemodialysis on the PK of JTZ-951 in Subjects With End-stage Renal Disease
Status: COMPLETED
Conditions: Anemia in Chronic Kidney Disease
Interventions: DRUG: JTZ-951
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeat Emergency Department Visits Among Patients With Asthma and COPD
Status: TERMINATED
Conditions: Asthma|COPD
Interventions: DRUG: beclamethasone dipropionate|DRUG: albuterol|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sunitinib Malate and Capecitabine in Treating Patients With Unresectable or Metastatic Liver Cancer
Status: TERMINATED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer
Interventions: DRUG: sunitinib malate|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function
Status: TERMINATED
Conditions: Smoking|Endothelial Dysfunction
Interventions: OTHER: Charcoal hookah|OTHER: E-coal hookah|OTHER: Cigarette|DRUG: Carbon Monoxide inhalation|OTHER: Room Air inhalation|DRUG: vitamin C|DRUG: tadalafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation
Status: COMPLETED
Conditions: Respiratory Distress Syndrome in Premature Infants|Very Low Birth Weight Baby
Interventions: DRUG: iNO|OTHER: Nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SUPARTZ Versus Placebo in Osteoarthritis of the Shoulder
Status: COMPLETED
Conditions: Osteoarthritis of the Shoulder
Interventions: DEVICE: SUPARTZ®|DEVICE: Phosphate Buffered Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Status: COMPLETED
Conditions: Stress
Interventions: DRUG: Metyrapone|DRUG: Dexamethasone|DRUG: Cortrosyn|DRUG: Corticorelin ovine triflutate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of GlutenShield, a Prebiotic, Probiotic, and Enzyme Supplement, on the Gut Microbiome of Adults With GI Symptoms
Status: UNKNOWN
Conditions: Gastrointestinal Symptoms
Interventions: DIETARY_SUPPLEMENT: GlutenShield|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Feasibility Study of Endobronchial Ultrasound Transbronchial Cryobiopsy (EBUS-TBCB 1.1 mm Probe) Among Patients With Mediastinal Lymphadenopathies
Status: NOT_YET_RECRUITING
Conditions: Endobronchial Mass
Interventions: PROCEDURE: Endobronchial ultrasound transbronchial cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects Of Unilateral Forearm Vibration On The Loss Of Muscle And Bone Of Contralateral Forearm
Status: WITHDRAWN
Conditions: Effects of Vibration
Interventions: OTHER: Forearm vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE