pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Assess Safety & Efficacy of Sitagliptin as Initial Oral Therapy for Treatment of Type 2 Diabetes Mellitus in Pediatric Participants. (MK-0431-083)
Status: COMPLETED
Conditions: Diabetes Mellitus|Type 2 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: Metformin|DRUG: Placebo to sitagliptin|DRUG: Placebo to metformin|DRUG: Glycemic Rescue 1|BIOLOGICAL: Glycemic Rescue 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy
Status: COMPLETED
Conditions: Immunity
Interventions: OTHER: Infant formula with added synbiotics|OTHER: Standard infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine, Docetaxel, and Capecitabine in Treating Patients With Cancer of Unknown Primary Origin
Status: WITHDRAWN
Conditions: Carcinoma of Unknown Primary
Interventions: DRUG: capecitabine|DRUG: docetaxel|DRUG: gemcitabine hydrochloride|PROCEDURE: positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dalfampridine in Patients With Hereditary Spastic Paraplegia
Status: COMPLETED
Conditions: Hereditary Spastic Paraplegia
Interventions: DRUG: Dalfampridine 10 MG|DRUG: Placebo|BEHAVIORAL: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Progesterone Prevent Very Preterm Delivery in Twin Pregnancies?
Status: COMPLETED
Conditions: Preterm Delivery
Interventions: DRUG: Progesterone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Using SMART Experimental Design to Personalize Treatment for Child Depression
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Caregiver-Child Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I Trial of Tariquidar (XR9576) in Combination With Doxorubicin, Vinorelbine, or Docetaxel in Pediatric Patients With Solid Tumors
Status: COMPLETED
Conditions: Wilms' Tumor|Sarcoma|Adenaocortical Carcinoma|Refractory Cancer|Coldrhood Cancer
Interventions: DRUG: Tariquidar
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arterial Pulse Waveform Contour Analysis for Intraoperative Goal Directed Therapy in Major Abdominal Surgery
Status: COMPLETED
Conditions: Surgical Procedures, Operative
Interventions: DEVICE: Vigileo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interferon γ-Primed Mesenchymal Stromal Cells as Prophylaxis for Acute Graft v Host Disease
Status: SUSPENDED
Conditions: Acute Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Interferon gamma (IFNγ)-primed human bone marrow-derived mesenchymal stromal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China
Status: RECRUITING
Conditions: Cognitive Impairment|Alzheimer Disease|Vascular Cognitive Impairment|Dement|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Neurocognitive Disorders|Mental Disorder|Cognition Disorder
Interventions: BEHAVIORAL: Structured Multi-domain Intervention|BEHAVIORAL: Self-Guided Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3209590 on Low Blood Sugar in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin Glargine|DRUG: LY3209590
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Corticosteroids in Community Acquired Pneumonia
Status: WITHDRAWN
Conditions: Community-acquired Pneumonia|Cognition Disorder
Interventions: DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Oxidative Stress Related to 2 Different Oxygen Concentrations During General Anesthesia. Clinical Trial.
Status: UNKNOWN
Conditions: Oxidative Stress
Interventions: DRUG: 30% of oxygen concentration.|DRUG: 60% of oxygen concentration.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xarelto for VTE Prophylaxis After Hip or Knee Arthroplasty
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Standard care treatment for VTE prophylaxis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: ferroquine (SSR97193)|DRUG: amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of VB-201 in Patients With Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: VB-201 160mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD22 Redirected Autologous T Cells for ALL
Status: RECRUITING
Conditions: B Cell Leukemias|B Cell Lymphomas
Interventions: BIOLOGICAL: CART22 cells transduced with a lentiviral vector to express anti-CD22 scFv TCRz:41BB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Appendicitis: Active Observation With and Without Antibiotics
Status: COMPLETED
Conditions: Appendicitis
Interventions: DRUG: Antibiotic treatment (Piperacillin/Tazobactam, 4 gram x 3), followed by 8-10 days of out-hospital oral antibiotic treatment (Ciprofloxacin 500 mgx2,Flagyl 400 mgx3).|OTHER: Active observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Effect of Exercise Training on Patients With Dementia and Mild Cognitive Impairment
Status: COMPLETED
Conditions: Dementia
Interventions: DEVICE: Strength training|DEVICE: Aerobic training|DEVICE: Isokinetic trinaing|DEVICE: Isotonic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factor XI LICA to Reduce Events Such as Heart Attack and Stroke in Patients Whose Kidneys Are no Longer Able to Work as They Should and Require Treatment to Filter Wastes From the Blood: Focus is on the Safety of BAY2976217 and the Way the Body Absorbs, Distributes and Removes the Study Drug
Status: COMPLETED
Conditions: End Stage Renal Disease Requiring Hemodialysis
Interventions: DRUG: Fesomersen sodium (BAY2976217)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Divalproex Sodium (Depakote) for Explosive Tempers in Adolescents and Adults
Status: COMPLETED
Conditions: Attention Deficit and Disruptive Behavior Disorders|Marijuana Abuse
Interventions: DRUG: Divalproex Sodium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double Blind Study in Pediatric Subjects With Chronic Plaque Psoriasis, Studying Adalimumab vs. Methotrexate
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: Adalimumab|DRUG: Methotrexate|BIOLOGICAL: Placebo to Adalimumab|DRUG: Placebo to Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy
Status: WITHDRAWN
Conditions: Merkel Cell Carcinoma|Islet Cell Carcinoma|Neuroendocrine Carcinoma|Pituitary Tumor
Interventions: DRUG: antineoplaston A10|DRUG: antineoplaston AS2-1|PROCEDURE: alternative product therapy|PROCEDURE: biological therapy|PROCEDURE: biologically based therapies|PROCEDURE: cancer prevention intervention|PROCEDURE: complementary and alternative therapy|PROCEDURE: differentiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vaginal Cuff Closure by Modification of the Bakay Technique in Total Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy|Surgery|Laparoscopy
Interventions: PROCEDURE: Modified Bakay technique (MT)|PROCEDURE: Standard technique (ST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AZD6244 (Selumetinib) in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of Remotely-Supervised Transcranial Direct Current Stimulation (RS-tDCS) to Enhance Motor Learning in Progressive Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Active RS-tDCS +At-Home Manual Dexterity Training|DEVICE: Sham RS-tDCS +At-Home Manual Dexterity Training|OTHER: Manual dexterity training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Combining Exome and Transcriptome Data to Unravel the Genetic Basis of the Lissencephalies
Status: NOT_YET_RECRUITING
Conditions: Classical Lissencephalies and Subcortical Band Heterotopias
Interventions: DIAGNOSTIC_TEST: Venipuncture and skin biopsy for RNA extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Sihogayonggolmoryeo-tang on the Anxiety of Hwa-byung
Status: UNKNOWN
Conditions: Hwa-byung
Interventions: DRUG: SIHOGAYONGGOLMORYU TANG EXTRACT GRAN|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating PK of PTH Administered Orally Via RaniPill™ Capsule
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: COMBINATION_PRODUCT: RT-102 (80 μg)|DRUG: Forteo|COMBINATION_PRODUCT: RT-102 (20 μg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin
Status: COMPLETED
Conditions: Trachoma|Lymphatic Filariases
Interventions: DRUG: Administration of Albendazole on Day 1|DRUG: Administration of Ivermectin on Day 1|DRUG: Administration of Azithromycin on Day 1|DRUG: Administration of Azithromycin on Day 15
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Reconstruction and Inverse Reconstruction in Right Atrium by Multimodal Echocardiographic Techniques
Status: UNKNOWN
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: radiofrequency ablation (RFCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Of Caffeine On Cognitive Performance
Status: COMPLETED
Conditions: Caffeine
Interventions: DIETARY_SUPPLEMENT: PLACEBO|DIETARY_SUPPLEMENT: 3 mg/kg of caffeine|DIETARY_SUPPLEMENT: 6 mg/kg of caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 2 Study of Panzem® NCD Alone and Combined With Sunitinib Malate in Patients With Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Panzem® NCD|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis
Status: COMPLETED
Conditions: Menopause|Multiple Sclerosis
Interventions: DRUG: Tissue Selective Estrogen Complex|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Chyle-leak After Major Pancreatic Surgery
Status: RECRUITING
Conditions: Lymph Leakage|Chyle Into Mesentery; Extravasation|Pancreatic Cancer|Complication of Surgical Procedure
Interventions: DIETARY_SUPPLEMENT: Diet group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Association Between the Use of Pulmonary Artery Catheter and Clinical Outcomes After Liver Transplantation
Status: UNKNOWN
Conditions: End Stage Liver DIsease|Liver Transplant; Complications|Liver Cirrhosis|Liver Diseases
Interventions: DEVICE: Pulmonary artery catheter (Edward Lifesciences, Irvine, California, USA)|DEVICE: FloTrac Vigileo system (EV1000 clinical platform, Edward Lifesciences, Irvine, California, USA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modified Radical Prostatectomy for Prostate Cancer Patients With Enlarged Prostate and Severe Lower Urinary Tract Symptoms: a Single-center, Retrospective Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: Two-step Radical Prostatectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Previously Collected and Stored Tissue Samples From Patients Previously Enrolled in a Completed National Cancer Institute Clinical Trial
Status: TERMINATED
Conditions: Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|OTHER: flow cytometry|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Ambulatory Peritoneal Dialysis With Telemedicine
Status: UNKNOWN
Conditions: Peritoneal Dialysis, Continuous Ambulatory
Interventions: DEVICE: Telemedicine software for data transmission and analysis in CAPD.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: In Vivo Evaluation of an Experimental Fluoride-containing Dentifrice With Hydrocolloid
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Dentifrice F-Complex|OTHER: Dentifrice F-Complex + NaF|OTHER: Dentifrice standard|OTHER: Dentifrice with tara gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Pembrolizumab and Cryoablation in People With Mesothelioma
Status: COMPLETED
Conditions: Lung Cancer|Unresectable Mesothelioma
Interventions: DRUG: Pembrolizumab|PROCEDURE: Image-guided cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab and Auto-HSCT Sandwich Strategy as Consolidation Therapy for B-ALL
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: COMBINATION_PRODUCT: blinatumomab and auto-HSCT "sandwich " strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III/Seroquel SR Bipolar Depression Monotherapy - US
Status: COMPLETED
Conditions: Affective Psychosis, Bipolar|Depression, Bipolar|Manic-Depressive Psychosis|Psychoses, Manic-Depressive
Interventions: DRUG: Quetiapine fumarate (Seroquel) SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSD
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: Brexpiprazole|DRUG: Sertraline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Indomethacin Prophylaxis for Heterotopic Ossification After Surgical Treatment of Elbow Trauma
Status: UNKNOWN
Conditions: Elbow Trauma Requiring Operative Management
Interventions: DRUG: Indomethacin and Pantoprazole|DRUG: microcrystalline cellulose powder tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of a Pre-Workout Dietary Supplement
Status: COMPLETED
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: C4 Extreme|DIETARY_SUPPLEMENT: C4 Extreme (without Advantra Z|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Open-Label, Long-term Study of GFB-887 in Patients With Glomerular Kidney Diseases
Status: TERMINATED
Conditions: Kidney Diseases|Glomerulosclerosis|Focal Segmental Nephrosis|Lipoid Urologic Disease|Glomerulonephritis|Nephritis|Nephrosis
Interventions: DRUG: GFB-887
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency as Open Label Extension
Status: ACTIVE_NOT_RECRUITING
Conditions: XIAP Deficiency|NLRC4-MAS
Interventions: DRUG: Tadekinig alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Inhaled Iloprost in Pediatric Patients With Pulmonary Arterial Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Iloprost Inhalation Solution (Ventavis)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Testicular Injury and Oligospermia
Status: RECRUITING
Conditions: Testicular Injury|Oligospermia
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Viral Pandemic Associated Risk of Cancer Death Using Less Invasive Diagnostic Tests- Liquid Biopsies
Status: RECRUITING
Conditions: Neoplasm, Colorectal|Neoplasm of Lung|Neoplasm, Bladder|Neoplasms Pancreatic|Biliary Tract Neoplasms|Gastro Intestinal Stromal Tumour
Interventions: OTHER: ctDNA blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Long-term Safety and Efficacy of ASP015K in Subjects Previously Enrolled in a Phase 2 ASP015K Rheumatoid Arthritis Study
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: peficitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy
Status: COMPLETED
Conditions: Malignant Head and Neck Neoplasm|Mucositis|Radiation-Induced Disorder
Interventions: OTHER: Educational Intervention|DRUG: Gabapentin|OTHER: Pain Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Oxycodone/Acetaminophen|DRUG: Hydrocodone/Acetaminophen|DRUG: Fentanyl|DRUG: Ibuprofen|DRUG: Magic Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non-invasive Solution for Periodontal and Peri-implant Diseases (INPERIO)
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DEVICE: Zirconia implants with G3-coated abutments (test implants and abutments)|DEVICE: Zirconia implants with control abutments (test implants, negative control abutments)|DEVICE: Titanium implants with G3-coated abutments (control implants, test abutments)|DEVICE: Titanium implants with control abutments (negative control implants and abutments)|DEVICE: Zirconia implants and titanium implants, for histological and histomorphometric evaluation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
Status: COMPLETED
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Caffeic acid tablets|DRUG: Dexamethasone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study Evaluating the 3P-100 Device in Subjects With PH-ILD
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension, Pulmonary|Lung Diseases, Interstitial
Interventions: DEVICE: Inhaled Nitric Oxide (iNO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SYH2039 in Participants With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced or Metastatic MTAP-deleted Solid Tumors
Interventions: DRUG: SYH2039
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses of BI 11634 Solution in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 11634 drinking solution|DRUG: BI 11634 tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Training in Fibrotic Interstitial Lung Disease
Status: RECRUITING
Conditions: Fibrotic Interstitial Lung Disease
Interventions: OTHER: High intensity interval training|OTHER: Traditional pulmonary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single-Photon Emission Computed Tomography, Computed Tomography Lymphoscintigraphy, and Intensity-Modulated Radiation Therapy in Treating Patients Who Have Undergone Surgery for Stage I or Stage II Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Lymphedema
Interventions: OTHER: screening questionnaire administration|PROCEDURE: computed tomography|PROCEDURE: lymphoscintigraphy|PROCEDURE: single photon emission computed tomography|RADIATION: intensity-modulated radiation therapy|RADIATION: technetium Tc 99m sulfur colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase II Study of MRG003 Injection Combined With Pucotenlimab Injection ± Cisplatin Injection in the Neoadjuvant Treatment Locally Advanced EGFR-positive Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: DRUG: MRG003 combined with Pucotenlimab|DRUG: MRG003 combined with Pucotenlimab+Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Feeding Interval of Preterms on the Time of Transition From Tube Feeding to Oral Feeding
Status: COMPLETED
Conditions: Bottlefeeding|Infant, Premature, Diseases
Interventions: OTHER: Q2 feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prolonged-Use of Inhaled Gaseous Nitric Oxide (gNO) for Adult With Non-Tuberculous Mycobacteria Infection
Status: COMPLETED
Conditions: Non-Tuberculous Mycobacterial Pneumonia
Interventions: DRUG: Nitric Oxide gas at 160ppm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia
Status: WITHDRAWN
Conditions: COVID-19|Olfactory Disorder|Parosmia
Interventions: DRUG: Fluvoxamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LY3527727) and Rosuvastatin in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rosuvastatin|DRUG: Pirtobrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of VX-661/Ivacaftor in Pediatric Subjects With Cystic Fibrosis (CF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: TEZ|DRUG: TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+
Status: COMPLETED
Conditions: HIV Seropositivity
Interventions: OTHER: ARV's + Placebo|DRUG: Naltrexone|DRUG: Naltrexone + ARV's
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma
Interventions: DRUG: Ivonescimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Microscale Organotypic Assays to Predict Patient Response to Anti-Angiogenesis Therapies
Status: TERMINATED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: PSMA-based 18F-DCFPyL PET tracer for PET/CT exams
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase With Thrombospondin Type-1 Motifs 13 (ADAMTS-13) Activity Ratio as a Predictor of Development of Extrahepatic Organ Failure in Acute on Chronic Liver Failure (ACLF) Patients.
Status: NOT_YET_RECRUITING
Conditions: Acute on Chronic Liver Failure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)
Status: RECRUITING
Conditions: Lung Cancer|Colorectal Cancer
Interventions: DRUG: 50 mg 89Zr-DFO-Nimotuzumab|DRUG: 1 mg 89Zr-DFO-Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection
Status: COMPLETED
Conditions: SARS-CoV-2 (COVID-19) Infection|Advanced or Metastatic Hematological or Solid Tumor
Interventions: DRUG: Autophagy inhibitor (GNS651)|OTHER: Standard of care|DRUG: Avdoralimab|DRUG: Monalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory Systemic Lupus Erythematosus
Status: NOT_YET_RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)|Lupus Nephritis (LN)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The European Bifurcation Club Left Main Study
Status: UNKNOWN
Conditions: Percutaneous Transluminal Coronary Angioplasty|Coronary Artery Disease
Interventions: DEVICE: 1 Stent|DEVICE: 2 Stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does MiECC Improve Outcome in Diabetic Patients Undergoing Elective Coronary Bypass Grafting?
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DEVICE: Minimally invasive extracorporeal circulation (MiECC)|DEVICE: Conventional extracorporeal circulation (CECC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement
Status: COMPLETED
Conditions: Pain|Hispanics|Opioid Use|Multimodal Analgesia|Total Knee Arthroplasty
Interventions: DRUG: Opioid based protocol|DRUG: Opioid sparing protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Ceramic Bearing Primary Total Hip Arthroplasty
Status: COMPLETED
Conditions: Total Hip Replacement
Interventions: DEVICE: Secure-Fit™ arc-deposited Hydroxylapatite (HA) shell - surface ceramic and an Alumina Bearing Couple (ABC) ceramic insert and Ceramic C-taper head|DEVICE: Secure-Fit™ arc-deposited hydroxylapatite shell, a Crossfire® insert and a Ceramic C-taper head
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare the Efficacy and Safety of Pegfilgrastim Biosimilar in Subjects With High Risk Stage Breast Cancer Receiving Chemotherapy
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Eurofarma's pegfilgrastim|DRUG: Neulastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MAP4343 Treatment for Alcohol Use Disorder
Status: WITHDRAWN
Conditions: Alcohol Use Disorder
Interventions: DRUG: MAP4343|DRUG: Placebo|BEHAVIORAL: Standardized behavioral counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Approaches for the Management of Post-dural Puncture Headache
Status: COMPLETED
Conditions: Post-Dural Puncture Headache
Interventions: PROCEDURE: sphenopalatine ganglion block|DRUG: paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HRS-7535 Tablets in Adults With Type 2 Diabetic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetic Kidney Disease
Interventions: DRUG: Placebo|DRUG: HRS-7535
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Trivalent Subunit Influenza Vaccine Produced in Mammalian Cell Culture Using the Strain Composition 2007/2008
Status: COMPLETED
Conditions: Seasonal Influenza Vaccine
Interventions: BIOLOGICAL: cTIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness of Ciclesonide Nasal Spray in Children (6 to 11 Years) With Perennial Allergic Rhinitis (BY9010/M1-403)
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis|Allergic Rhinitis|Hay Fever
Interventions: DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study Evaluating Tarceva in Combination With Avastin Versus Avastin Alone in Treating Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Metastases
Interventions: DRUG: Avastin (bevacizumab)|DRUG: Tarceva (erlotinib HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Radical Resection of Single-hole Inflatable Mediastinal Mirror Synchronization With Laparoscopic Esophageal Carcinoma
Status: UNKNOWN
Conditions: Esophagus Cancer
Interventions: PROCEDURE: Single-hole inflatable mediastinal mirror
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Aliviado DSD Caregiving Mastery Program
Status: RECRUITING
Conditions: Delirium Superimposed on Dementia
Interventions: BEHAVIORAL: Aliviado DSD Caregiving Mastery Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatmant of Oral Lichen Planus With Lycopene
Status: COMPLETED
Conditions: Lichen Planus, Oral
Interventions: DRUG: Lycopene|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIBW 2992 and Letrozole in Hormonoresistant Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: BIBW 2992|DRUG: BIBW 2992|DRUG: Letrozole|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-CBT (Cognitive Behavioral Therapy) for Depression and Anxiety in Parkinsons Disease
Status: COMPLETED
Conditions: Parkinson's Disease|Depression|Anxiety|Insomnia
Interventions: BEHAVIORAL: ICBT|BEHAVIORAL: ICONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micronutrient Dose Response Study in Bangladesh
Status: RECRUITING
Conditions: Micronutrient Status
Interventions: DIETARY_SUPPLEMENT: Micronutrient Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Beneficial Effects of Natural Products on Management of Xerostomia
Status: COMPLETED
Conditions: Xerostomia|Diabetes Mellitus|Hypertension|Post COVID-19 Condition
Interventions: OTHER: (Manuka honey-green tea)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib (ACP-196) in Combination With ACP-319, for Treatment of B-Cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkins Lymphoma|Multiple Myeloma|B-All
Interventions: DRUG: Acalabrutinib|DRUG: ACP-319
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Revascularization for Symptomatic Non-acute Carotid Artery Occlusion
Status: RECRUITING
Conditions: Non-acute Carotid Artery Occlusion
Interventions: PROCEDURE: Carotid Endarterectomy (CEA)|PROCEDURE: Carotid Artery Stenting (CAS)|PROCEDURE: Hybrid Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transient and Immediate Motor Effects of Exercise in Progressive Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis, Chronic Progressive|High-Intensity Interval Training|Motor Symptoms
Interventions: BEHAVIORAL: HIIT|BEHAVIORAL: MCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular Disease
Status: UNKNOWN
Conditions: Uncontrolled Hypertension|Cardiovascular Risk Factor
Interventions: BEHAVIORAL: Positive Psychological Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Intensity Ultrasound for the Treatment of Upper Inner Arm Skin Laxity
Status: UNKNOWN
Conditions: Skin Laxity
Interventions: DEVICE: Sofwave|DEVICE: Ultherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Between Two Clindamycin 1%/Benzoyl Peroxide 5% Topical Gels
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin 1% / Benzoyl Peroxide 5% (Perrigo)|DRUG: Clindamycin 1% / Benzoyl Peroxide 5% (Benzaclin)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographic Surgery
Status: COMPLETED
Conditions: Basal Cell Carcinoma|Squamous Cell Carcinoma|Skin Cancer|Anxiety
Interventions: DRUG: Randomized Midazolam|OTHER: Placebo|DRUG: Local Anesthesia|DRUG: Prospective Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK, Safety & Tolerability of CyCol® Versus Sandimmune® in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sandimmun® IV|DRUG: CyCol® capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Partial-Breast Radiation Therapy in Treating Women With Early-Stage Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: PROCEDURE: adjuvant therapy|RADIATION: accelerated partial breast irradiation|RADIATION: intracavitary balloon brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4D-CT-based Ventilation Imaging for Adaptive Functional Guidance in Radiotherapy
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DEVICE: Real-time Position Management system|DEVICE: Discovery ST multislice PET/CT scanner|DEVICE: Infinia Hawkeye SPECT/CT gamma camera|DEVICE: Pinnacle3 treatment planning system|DEVICE: SKYLight nuclear camera|DRUG: DTPA|DRUG: TECHNETIUM TC 99M MAA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of HIV1 Mother to Child Transmission Without Nucleoside Analogue Reverse Transcriptase Inhibitors in the Pre-partum Phase. ANRS 135 Primeva
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Kaletra (lopinavir/ritonavir)|DRUG: Kaletra (lopinavir/ritonavir) + Combivir (zidovudine/lamivudine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrquency Targeting Mid Cervical Medial Branches vs GON in Cervicogenic Headache
Status: UNKNOWN
Conditions: Cervicogenic Headache
Interventions: DEVICE: Radiofrequency|PROCEDURE: Greater occipital nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Design Study of NEST sTMS in Subjects With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder|Depression|Depressive Disorder, Major|Depressive Episode|Major Depressive Disorder
Interventions: DEVICE: Synchronized Transcranial Magnetic Stimulation (sTMS)|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Ginger (Zingiber Officinale) Extract "Ginpax" to Manage Nausea in Cancer Patients Receiving High Emetogenic Treatments and Standard Anti-emetogenic Therapy
Status: COMPLETED
Conditions: Cancer|Nausea|Vomiting
Interventions: DIETARY_SUPPLEMENT: Standardized Ginger extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial
Status: RECRUITING
Conditions: On-pump Cardiac Surgery|High Risk for Bleeding|Autotransfusion
Interventions: PROCEDURE: Autotransfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: CyberKnife Stereotactic Accelerated Partial Breast Irradiation (SAPBI)
Status: TERMINATED
Conditions: Breast Cancer|DCIS|Invasive Ductal Carcinoma
Interventions: RADIATION: CK Stereotactic Accelerated Partial Breast Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dronabinol in the Improvement of Chemotherapy-induced and Tumor-related Symptoms in Advanced Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer Non-resectable|Chemotherapy-induced Nausea and Vomiting|Pancreatic Cancer Metastatic
Interventions: DRUG: Dronabinol in Oral Dosage Form|DRUG: Placebo in Oral Dosage Form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Performing a Composite Test 3 Months Post-operatively Reduce the Risk of Failure to Return to Sport After Lateral Ankle Ligamentoplasty?
Status: RECRUITING
Conditions: Ankle Injuries
Interventions: OTHER: Personnalized physiotherapy|OTHER: Usual physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of rBet v1 Tablets
Status: COMPLETED
Conditions: Birch Pollen-related Rhinoconjunctivitis|Rhinitis, Allergic, Seasonal
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: rBet v 1|BIOLOGICAL: rBet v 1|BIOLOGICAL: rBet v 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Afimoxifene Gel to Treat Cyclic Mastalgia in Premenopausal Women
Status: COMPLETED
Conditions: Cyclic Breast Pain, Cyclic Mastalgia
Interventions: DRUG: Afimoxifene (0.057%) in hydroalcoholic gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone, Azacytidine,Pegaspargase and Tislelizumab for NK/T Cell Lymphoma
Status: UNKNOWN
Conditions: NK/T Cell Lymphoma
Interventions: DRUG: Dexamethasone, azacytidine, Pegaspargase, Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Transdiagnostic Sleep and Circadian Intervention for Patients With Mental Disorders and Sleep Problems
Status: UNKNOWN
Conditions: Depression|Bipolar Affective Disorder|Attention Deficit Disorder
Interventions: BEHAVIORAL: Transdiagnostic sleep and circadian treatment|BEHAVIORAL: Active waitlist control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Flash Glucose Monitoring in People With Type 2 Diabetes Using Non-Insulin Antihyperglycemic Therapy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Glucose
Interventions: DEVICE: FreeStyle Libre Flash Glucose Monitor|OTHER: Diabetes self-management education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Count（PC）/Spleen Diameter(SD) Ratio to Predict the Variceal Haemorrhage in HBV Cirrhotic Patients in China
Status: COMPLETED
Conditions: Platelet Count/Spleen Diameter Ratio|Child-Pugh Classification
Interventions: OTHER: Platelet count/spleen diameter ratio
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p