pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency
Status: COMPLETED
Conditions: Common Variable Immunodeficiency|Agammaglobulinemia
Interventions: DRUG: Vivaglobin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Nicotinamide for Early Onset Preeclampsia
Status: COMPLETED
Conditions: Pregnancy Induced Hypertension|Superimposed Preeclampsia|Hypertension
Interventions: DRUG: Nicotinamide 500 mg|DRUG: Nicotinamide 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RandomizEd ClinicAL triaL on the Efficacy and saFety of Incremental Hemodialysis (REAL-LIFE)
Status: RECRUITING
Conditions: End Stage Renal Disease on Dialysis
Interventions: PROCEDURE: Incremental hemodialysis|PROCEDURE: Conventional hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK)/Pharmacodynamic (PD), Study of Single-dose Subcutaneous CDP6038 in Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: CDP6038|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Radiofrequency Ablation of Atrial Fibrillation Under Apnea
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: OTHER: Periods of Apnea|OTHER: Control Arm - No Periods of Apnea
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
Status: ENROLLING_BY_INVITATION
Conditions: Opioid Use Disorder|Substance-Related Disorders|Pregnancy Related|Narcotic-Related Disorders|Buprenorphine Dependence|Methadone Dependence
Interventions: DRUG: Buprenorphine or Methadone Treatment|DIAGNOSTIC_TEST: Fetal and Placental MRI|BEHAVIORAL: Child Developmental Assessment|BEHAVIORAL: Questionnaires|OTHER: Blood and Placental Samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Different Levels of Guidance in iCBT for Depression (RCT)
Status: COMPLETED
Conditions: Depressive Symptoms|Quality of Life|Self Esteem
Interventions: BEHAVIORAL: Selfapy with therapeutic guidance|BEHAVIORAL: Selfapy with additional peer support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixazomib in Combination With Thalidomide - Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Thalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Wasabi Leaf Extract on Skin
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Placebo drink|DIETARY_SUPPLEMENT: Wasabi Leaf Extract Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: COBRA PZF™ Coronary Stent for Early Healing, Thrombus Inhibition, Endothelialization and Avoiding Long-Term DAPT
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: COBRA PzF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Polarized Exercise in Adolescents With Severe Obesity (ALPOLAROB)
Status: RECRUITING
Conditions: Obesity|Exercise Training
Interventions: OTHER: Polarized workout program|OTHER: High intensity workout program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Safety and Effectiveness Pilot Study of PRF-108 and PRF-110 in Healthy Volunteers
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: PRF-108|DRUG: Placebo|DRUG: Ropivacaine|DRUG: PRF-110
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Flexible Sigmoidoscopy Screening as an Adjunct to the National FOBT Screening Programme in Scotland
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Adenoma
Interventions: PROCEDURE: Flexible Sigmoidoscopy|OTHER: Fecal occult blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of Generic to Brand Tacrolimus in Stable Renal Transplant Patients
Status: COMPLETED
Conditions: Renal Transplant
Interventions: DRUG: Generic Tacrolimus|DRUG: Branded Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study of rhFGF 18 in Patients With Knee Osteoarthritis Not Requiring Surgery
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: AS902330
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIL Therapy for Patients With Advanced Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Breast Cancer|Advanced Lung Cancer
Interventions: BIOLOGICAL: Tumor-infiltrating lymphocytes|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vildagliptin Added to Continuous Subcutaneous Insulin Infusion in Uncontrolled Type 2 Diabetes
Status: UNKNOWN
Conditions: T2DM
Interventions: DRUG: CSII+Vildagliptin|DRUG: CSII(insulin Lispro)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Autologous Human Umbilical Cord Blood Mononuclear Fraction to Treat Acquired Hearing Loss in Children
Status: WITHDRAWN
Conditions: Hearing Loss
Interventions: BIOLOGICAL: Autologous Human Umbilical Cord Blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of 48 Versus 96 Weeks of Peginterferon Alfa-2a [Pegasys] Treatment, With or Without Entecavir, in Patients With Chronic Hepatitis B.
Status: WITHDRAWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: entecavir|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant With or Without Lapatinib and/or Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast Cancer That Progressed After Previous Aromatase Inhibitor Therapy
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: exemestane|DRUG: fulvestrant|DRUG: lapatinib ditosylate|DRUG: letrozole|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid Arthritis
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Fontolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Infant Formulas Supplemented With Pre- and Probiotic(s)
Status: COMPLETED
Conditions: Healthy Infants
Interventions: OTHER: Experimental formulas (EF)|OTHER: Control formulas (CF)|OTHER: Breast feeding (BF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Gestational Weight and Incentive Research Study
Status: COMPLETED
Conditions: Gestational Weight Gain
Interventions: BEHAVIORAL: Lottery + Monthly Weight|BEHAVIORAL: Lottery + Overall Weight + Exercise|BEHAVIORAL: Lottery + Overall Weight|BEHAVIORAL: Loss + Overall Weight|BEHAVIORAL: Loss + Overall Weight + Exercise|BEHAVIORAL: Lottery + Monthly Weight + Exercise|BEHAVIORAL: Loss + Monthly Weight|BEHAVIORAL: Loss + Monthly Weight + Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Camrelizumab and Apatinib for Neoadjuvant Therapy in Thyroid Cancer
Status: UNKNOWN
Conditions: Thyroid Cancer
Interventions: DRUG: Camrelizumab and Apatinib|PROCEDURE: surgery|PROCEDURE: core needle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of NULOJIX® Usage Towards Minimizing CNI Exposure in Simultaneous Pancreas and Kidney Transplantation
Status: TERMINATED
Conditions: Simultaneous Kidney and Pancreas Transplantation
Interventions: BIOLOGICAL: Belatacept|DRUG: methylprednisolone|BIOLOGICAL: Anti-thymocyte Globulin (Rabbit)|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IDP-123 Lotion to Tazorac® Cream, in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-123 Lotion|DRUG: Tazorac Cream|DRUG: Vehicle Lotion|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Instestinal Microbiome of Patients With Transthyretin Amyloidosis
Status: UNKNOWN
Conditions: Amyloidosis, Hereditary, Transthyretin-Related|Microbial Colonization
Interventions: DIAGNOSTIC_TEST: collection of stools for genetic analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating an Enhanced Home-delivered Meal Program on Older Adults' Health and Well-being
Status: NOT_YET_RECRUITING
Conditions: Diet, Healthy|Food Insecurity|Loneliness|Quality of Life
Interventions: OTHER: Home-delivered meals|OTHER: Wellness check and socialization visit|BEHAVIORAL: Community Health Worker calls|OTHER: Supplemental grocery bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Electroacupuncture Combined With NGF on Clinical Effect and Functional Changes on Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: Nerver growth factor (NGF) injection|DRUG: Placebo injection|DEVICE: EA intervention|DEVICE: sham EA intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Next Science Wound Gel Efficacy in Chronic Wound Versus Standard of Care
Status: COMPLETED
Conditions: Wound Chronic Draining
Interventions: DEVICE: Next Science Wound Gel|DRUG: Triple Antibiotic Ointment Neosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Efficacy of Remimazolam in Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
Status: NOT_YET_RECRUITING
Conditions: Midazolam|Remimazolam
Interventions: DRUG: Byfavo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Videolaryngoscope on Intraocular Pressure
Status: COMPLETED
Conditions: Intubation Complication
Interventions: DEVICE: Mcgrath|DEVICE: Macintosh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study of HX008 Compared to Chemotherapy in the First-Line Treatment of Subjects With MSI-H/dMMR Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: HX008|DRUG: Investigator's Choice Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092)
Status: COMPLETED
Conditions: Infection|Pneumonia
Interventions: DRUG: MK0787B, imipenem/cilastatin sodium / Duration of Treatment: 7 Days|DRUG: Comparator: amikacin / Duration of Treatment: 3 Days|DRUG: Comparator: tazocin / Duration of Treatment: 3 Days|DRUG: Comparator: vancomycin / Duration of Treatment: 3 Days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: hOKT3γ1 (Ala-Ala) Combined With Sirolimus and Delayed Tacrolimus in Type 1 Diabetic Islet Allograft Recipients
Status: COMPLETED
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DRUG: Allogeneic Islets of Langerhans|DRUG: hOKT3γ1 (Ala-Ala)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modeling and Predicting Real World Behavior Using Mobile Sensor Data on Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: OTHER: Behavioral-data driven support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Methemoglobinemia|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Nonmalignant Neoplasm
Interventions: DRUG: chemotherapy|DRUG: dapsone|OTHER: medical chart review|PROCEDURE: assessment of therapy complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Atrial Fibrillation Health Literacy and Information Technology Trial
Status: COMPLETED
Conditions: Atrial Fibrillation|Familial Atrial Fibrillation|Arrythmia, Cardiac|Heart Diseases|Pathologic Processes
Interventions: BEHAVIORAL: Relational Agent and heart rate and rhythm monitor|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Positron Emission Tomography Using Carbon-11 Acetate and Fludeoxyglucose F 18 in Detecting Hepatocellular Carcinoma (Liver Cancer) in Patients With Known or Suspected Liver Cancer
Status: COMPLETED
Conditions: Liver Cancer
Interventions: PROCEDURE: 18F-Fluorodeoxyglucose-PET (FDG-PET)|PROCEDURE: 11Carbon-Acetate-PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Text Messaging Intervention to Improve Retention in Care and Virologic Suppression in an Urban HIV-Infected Population
Status: COMPLETED
Conditions: HIV|Patient Adherence|Mobile Technology
Interventions: BEHAVIORAL: Text Messages|BEHAVIORAL: Appointment Reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phenylbutyrate in Proteinuric Nephropathies
Status: COMPLETED
Conditions: Proteinuric Diseases
Interventions: DRUG: PBA 7,5g/d|DRUG: PBA 15g/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Irbesartan/Amlodipine 4 Fixed Combination Therapy in Hypertensive Patients Uncontrolled on Irbesartan or Amlodipine Monotherapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan/Amlodipine (150/5mg)|DRUG: Irbesartan/Amlodipine (150/10mg)|DRUG: Irbesartan/Amlodipine (300/5mg)|DRUG: Irbesartan/Amlodipine (300/10mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Electro-kinetically Modified Water for the Treatment of Pain Associated With Endometriosis
Status: TERMINATED
Conditions: Pelvic Pain
Interventions: OTHER: Electro-kinetically Modified Water|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exteriorization Versus Non-exteriorization of the Uterus During Repair of Uterine Incision in a Repeated Cesarean Section
Status: COMPLETED
Conditions: Intrapartum Hemorrhage
Interventions: PROCEDURE: Repair of uterine incision|PROCEDURE: Exteriorization of the uterus|PROCEDURE: Non exteriorization of the uterus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Low-Dose Celecoxib on SMN2 in Patients With Spinal Muscular Atrophy
Status: TERMINATED
Conditions: Spinal Muscular Atrophy (SMA)
Interventions: DRUG: celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Allopurinol on Inflammation and Ultrasonographic Changes in People With Elevated Uric Acid But no Symptoms
Status: UNKNOWN
Conditions: Musculoskeletal Degeneration|Inflammation|Hyperuricemia
Interventions: DRUG: Allopurinol Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Mental Health Disparities in Refugee Children: A Community-based Participatory Research (CBPR) Collaboration
Status: COMPLETED
Conditions: Child/Adolescent Problems|Mental Disorders
Interventions: BEHAVIORAL: Family Strengthening Intervention-Refugees
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers
Status: UNKNOWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: DN1406131|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of Two Different Fluoride Applications
Status: COMPLETED
Conditions: White Spot Lesion
Interventions: DEVICE: Fluoride Application (Experimental Fluoride Application)|DEVICE: Fluor Protector S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Patent Ductus in Premature Infants
Status: COMPLETED
Conditions: Cardiovascular Diseases|Defect, Congenital Heart|Ductus Arteriosus, Patent|Heart Diseases
Interventions: DRUG: indomethacin|PROCEDURE: surgery, cardiovascular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Saracatinib in Treating Patients With Locally Advanced or Metastatic Stomach or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Adenocarcinoma of the Stomach|Recurrent Gastric Cancer|Stage III Gastric Cancer|Stage III Esophageal Cancer|Stage IV Esophageal Cancer|Stage IV Gastric Cancer
Interventions: DRUG: saracatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Infiltration With Bupivacaine to Increase Quality of Post-operative Pain Control in Total Knee Replacement
Status: COMPLETED
Conditions: Pain, Postoperative|Arthropathy of Knee Joint
Interventions: DRUG: 0.25% Bupivacaine|DRUG: 0.9% normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using of Extracorporeal Shockwave Therapy in Treatment Of Achilles Tendinopathy
Status: COMPLETED
Conditions: Achilles Tendinopathy
Interventions: DEVICE: Extracorporeal Shockwave Therapy(ESWT)|OTHER: Eccentric training of the calf muscle:|OTHER: Gastrocnemius, soleus, and hamstring stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dolutegravir-Lamivudine as Dual Therapy in naïve HIV-Infected Patients With Documented M184V Mutation:A Pilot Study
Status: WITHDRAWN
Conditions: HIV-1 Infection
Interventions: DRUG: Dolutegravir plus lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Two Different Goals of Fluid Management in Patients Undergoing Supratentorial Tumour Resection
Status: NOT_YET_RECRUITING
Conditions: Supratentorial Brain Tumor
Interventions: OTHER: pulse pressure variation index guided fluid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Crossover Trial of AD109 in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: AD109|DRUG: Atomoxetine|DRUG: R-oxybutynin|DRUG: Placebo|DIAGNOSTIC_TEST: Digit System Substitution Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Metformin in Association to Chemoradiotherapy for Locally Advanced Rectal Cancer
Status: TERMINATED
Conditions: Rectal Neoplasms|Adenocarcinoma|Carcinoma
Interventions: DRUG: Capecitabine|DRUG: Metformin|RADIATION: Radiotherapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial of Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (rHuGM-CSF), Recombinant Alpha Interferon and Azidothymidine (AZT) in AIDS-Associated Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Interferon alfa-2b|DRUG: Zidovudine|DRUG: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Leukemia of Ambiguous Lineage in Relapse|Acute Myeloid Leukemia, in Relapse|Refractory Acute Leukemia of Ambiguous Lineage|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax|DRUG: Selinexor|DRUG: Cytarabine|DRUG: Fludarabine|BIOLOGICAL: Filgrastim|DRUG: Methotrexate|DRUG: methotrexate/hydrocortisone/cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intradialytic Exercises During Hemodialysis
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DEVICE: Medical Exercise Peddler 3000, Medi-Bike, Taiwan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Epidemiology of Parkinson's Disease in Croatia and the Influence of Genetic Factors and Microbiota on the Progression and Treatment Outcomes of the Disease (GiOPARK)
Status: UNKNOWN
Conditions: Parkinson Disease|Genetic Disease|Microbiota|Neuro-Degenerative Disease|Neuroinflammatory Response
Interventions: DIAGNOSTIC_TEST: Whole-exome sequencing|DIAGNOSTIC_TEST: Microbiota sequencing|DIAGNOSTIC_TEST: Magnetic resonance imaging|DIAGNOSTIC_TEST: Transcranial ultrasound and Electroencephalography|DIAGNOSTIC_TEST: ELISA (Enzyme-Linked Immunosorbent Assay)|DIAGNOSTIC_TEST: Fluorescent correlation spectroscopy (FCS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Microbial Surveillance in Children Hospitalized for Cardiovascular Surgery
Status: UNKNOWN
Conditions: Cardiac Surgery|Perioperative Prophylaxis
Interventions: PROCEDURE: samples from nostrils, mouth, axillas, perianal area and postoperative wound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Social Decision-making (SOCIAL-DECISION)
Status: TERMINATED
Conditions: Healthy
Interventions: OTHER: How people learn another's value preference during decision under risk|OTHER: Neural mechanism of making a group decision under risk that influences on in-group members|OTHER: Neural mechanism of making a group decision that influences on out-group members|OTHER: fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: mesna|DRUG: methotrexate|DRUG: prednisone|DRUG: therapeutic hydrocortisone|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Enteral-extended Anti-reflux Stents for Pancreatic Pseudocyst
Status: RECRUITING
Conditions: Pancreatic Pseudocyst
Interventions: COMBINATION_PRODUCT: Plant enteral-extended anti-reflux stents|COMBINATION_PRODUCT: Plant traditional stents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Women's Walking Program
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Walking Program + Motivational Interviewing Calls|BEHAVIORAL: Walking Program + Automated Calls|BEHAVIORAL: Walking Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy
Status: UNKNOWN
Conditions: Depressive Symptoms|Impaired Cognition|Electroconvulsive Therapy
Interventions: DRUG: ketamine and propofol|DRUG: propofol and normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corifollitropin Alfa Followed by hpHMG in a Long GnRH Agonist Protocol for the Treatment of Poor Ovarian Responders
Status: COMPLETED
Conditions: Infertility|Poor Ovarian Response
Interventions: DRUG: Triptorelin|DRUG: Corifollitropin alfa 150μg|DRUG: hpHMG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: DRUG: Celecoxib+Pregabalin+Vitamin B fixed dose|DRUG: Celecoxib + Vitamin B fixed dose|DRUG: Pregabalin + Vitamin B fixed dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Transfer Energy Capacitive and Resistive Therapy in Patients With Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Energy Transfer Capacitative and Resistive Therapy
Interventions: DEVICE: US therapy|DEVICE: TECAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of the Femoral Implant "Y-strut" on Lytic Bone Metastases of the Femoral Neck (WAZA-ARY)
Status: UNKNOWN
Conditions: Neoplasms, Bone Tissue|Pain, Intractable|Hip Fractures
Interventions: DEVICE: Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TIMES: Ticagrelor vs. Placebo/ Clopidogrel With Aspirin in Anterior STEMI Patients Treated With Primary PCI
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Ticagrelor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Study of the LMA SupremeTM vs Ambu-Aura GainTM
Status: UNKNOWN
Conditions: Airway Morbidity
Interventions: PROCEDURE: function tests|DEVICE: LMA SupremeTM|DEVICE: Ambu-Aura GainTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients.
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Acacia catechu|DRUG: Chlorhexidine gluconate|OTHER: Distilled water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HIPEC in Ovarian Carcinoma Clinical Stage IIIC and IV During Interval Laparotomy
Status: RECRUITING
Conditions: HPEC|Ovarian Cancer|Women's Health: Neoplasm of Ovary|Chemotherapy Effect
Interventions: PROCEDURE: HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial Designed to Determine Efficacy and Safety of Bendamustine+Dexamethasone+Thalidomide in R/R MM
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bendamustine|DRUG: Thalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate NBI-827104 in Pediatric Participants With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep
Status: ENROLLING_BY_INVITATION
Conditions: Epileptic Encephalopathy|Continuous Spike and Wave During Sleep
Interventions: DRUG: NBI-827104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of LY3209590 in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LY3209590|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.
Status: TERMINATED
Conditions: Heavy Proteinuria
Interventions: DRUG: ramipril 5 mg + valsartan 80 mg/day,|DRUG: ramipril 10 mg + valsartan 160 mg/day,|DRUG: ramipril 5 mg + valsartan 80 mg/day + increased dosage of furosémide.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: HLT transfemOral Replacement of aortIc Valve Via transcatherteriZatiON CANADA
Status: WITHDRAWN
Conditions: Severe Aortic Stenosis
Interventions: DEVICE: HLT Transcatheter Aortic Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D2C7-IT With Atezolizumab for Recurrent Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Glioma
Interventions: DRUG: D2C7-IT (6920 ng/mL via convection-enhanced delivery)|DRUG: Atezolizumab (1200 mg every three weeks)|DRUG: D2C7-IT (4613.2 ng/mL via convection-enhanced delivery)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Family Intervention Program for the Management of Overweight or Obese Children
Status: UNKNOWN
Conditions: Overweight|Obesity|Children
Interventions: BEHAVIORAL: Counselling group|BEHAVIORAL: Nereu group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effect of Liposomal L-Arg and Vit C Integration on Mitochondrial Function in Patients With Heart Failure
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: L-arginine and liposomal vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PCLs Using Three EUS-FNA Needles
Status: COMPLETED
Conditions: Pancreatic Cystic Lesions
Interventions: DEVICE: 19 G Flex Needle|DEVICE: 22 G Needle|DEVICE: 19 G Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of hLL1-DOX (Milatuzumab-Doxorubicin Antibody-Drug Conjugate) in Patients With Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: hLL1-DOX (the doxorubicin conjugate of milatuzumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of OPC-41061 Orally Disintegrating (OD) Tablets Using 2 Different Formulations and 2 Dosing Regimens in Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Healthy Adult Male
Interventions: DRUG: OPC-41061
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Physical Therapy With Vestibular Stimulation to Improve Postural Stability in Pusher's Syndrome
Status: WITHDRAWN
Conditions: Pusher Syndrome
Interventions: DEVICE: Galvanic Vestibular Stimulation|OTHER: Standard Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reshaping the Path of Vascular Cognitive Impairment (VCI)
Status: COMPLETED
Conditions: Transient Ischemic Attack|Vascular Cognitive Impairment|Subcortical Vascular Dementia
Interventions: BEHAVIORAL: Resistance exercise training|BEHAVIORAL: Control: stretching and relaxation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intra-operative Imaging in Women With Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Ovarian Carcinoma
Interventions: DIAGNOSTIC_TEST: Intravenous Indocyanine Green/ICG injection|DIAGNOSTIC_TEST: PINPOINT endoscopic fluorescence imaging system|DIAGNOSTIC_TEST: Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Baclofen for Smoking Cessation in a Non-Psychiatric Population
Status: TERMINATED
Conditions: Nicotine Dependence
Interventions: DRUG: Baclofen 30 mg/day|DRUG: placebo pill|DRUG: Baclofen 60 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduce Risk for Crohn's Disease Patients
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: DRUG: Methotrexate|DRUG: Adalimumab|DRUG: Azathioprine / 6 Mercaptopurine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Adult
Interventions: DRUG: BIO-11006|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Dexamethasone Vs. Conventional Dose Prednisolone in Adult ITP
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: Dexamethasone|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Trifluridine and Tipiracil Tablets in Colorectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Trifluridine and Tipiracil Tablets|DRUG: TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Analgesia and Sedation Using Intranasal Dexmedetomidine in Third Molar Surgery Under Local Anaesthesia
Status: COMPLETED
Conditions: Pain|Sedation
Interventions: DRUG: Intranasal dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Pre-Incisional Ketorolac for Patients Undergoing Surgery for Non-Small Cell Lung Cancer and Renal Cell Carcinoma
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Renal Cell Carcinoma
Interventions: DRUG: Preoperative Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation (AF)|Persistent Atrial Fibrillation|Longstanding Persistent Atrial Fibrillation
Interventions: DEVICE: AtriCure CryoICE & AtriClip LAA Exclusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation for the Prevention of Cardiovascular Risk
Status: COMPLETED
Conditions: Obesity|Overweight|Insulin Resistance
Interventions: DRUG: Vitamin D|DRUG: Placebo (for vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: QUILT-3.020: A Study of ALT-801 in Patients With Relapsed or Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: ALT-801
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MGUS, SMM, and MM Patient Experience With Coronavirus 19 (COVID-19) Survey
Status: UNKNOWN
Conditions: Multiple Myeloma|Smoldering Multiple Myeloma|Monoclonal Gammopathy of Undetermined Significance|Coronavirus
Interventions: BEHAVIORAL: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating High-flow Nasal Cannula Oxygen Therapy Through LUS During Weaning
Status: UNKNOWN
Conditions: High-flow Nasal Cannula Oxygen
Interventions: DEVICE: high-flow nasal cannula oxygen|DEVICE: Conventional oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty
Status: TERMINATED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aprepitant PO vs Ondansetron IV for Prevention of Postoperative Nausea and Vomiting
Status: WITHDRAWN
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: aprepitant 40 mg|DRUG: ondansetron 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lidocaine for Oxaliplatin-induced Neuropathy
Status: COMPLETED
Conditions: Neuropathy, Painful|Chemotherapy-induced Peripheral Neuropathy|Colorectal Cancer
Interventions: DRUG: Lidocaine Hydrochloride|DRUG: Placebo|DRUG: FOLFOX regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RCT of Motor Imagery of Extension for LBP vs. Exercise
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Motor Imagery. Imaging doing Extension exercises without actually doing them.|OTHER: Control: Physically performing extension based exercises.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Local Haemodynamic Effects of Apelin Agonists and Antagonists in Man in Vivo
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: PROCEDURE: Forearm venous occlusion plethysmography|PROCEDURE: Aellig hand vein technique|OTHER: Apelin agonist infusion|OTHER: Apelin receptor antagonist infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dental Cement in Post-operative Sensitivity: Randomized Clinical Trial
Status: COMPLETED
Conditions: Restored Decayed Teeth and Post-operative Sensitivity
Interventions: DEVICE: Teeth treated with composite resin, control group|DEVICE: Teeth treated with lining, pulp wall with PBS DTA® cement and composite resin restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy With or Without Sintilimab in Limited-stage SCLC
Status: UNKNOWN
Conditions: Small Cell Lung Cancer Limited Stage
Interventions: DRUG: Sintilimab|DRUG: Etoposide|DRUG: Cisplatin|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An mHealth Self-Management Program to Decrease Postoperative Symptom Distress
Status: COMPLETED
Conditions: Orthopaedic Surgery
Interventions: OTHER: mHealth application (PoCAH)|OTHER: As usual standard discharge and care instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D3-enhanced Eggs in Preschool Children
Status: COMPLETED
Conditions: Vitamin D Deficiency|25-Hydroxyvitamin D3 Deficiency, Selective
Interventions: DIETARY_SUPPLEMENT: vitamin D-enhanced egg|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wisconsin Tobacco Quit Line Medicaid Incentive Evaluation
Status: COMPLETED
Conditions: Smoking|Smoking Cessation|Nicotine Dependence
Interventions: BEHAVIORAL: Counseling from WTQL|OTHER: Financial incentive to participate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease
Status: NOT_YET_RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Mycophenolate Mofetil and Tacrolimus in the Treatment of Membranous Lupus Nephritis
Status: COMPLETED
Conditions: Lupus Nephritis|Glomerulonephritis, Membranous
Interventions: DRUG: prednisolone and mycophenolate mofetil|DRUG: prednisolone and tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell-Based Tumor Vaccine Adjuvant Immunotherapy of Human Glioblastoma Multiforme (WHO Grade IV Gliomas)
Status: UNKNOWN
Conditions: Glioblastoma Multiforme|Glioblastoma
Interventions: BIOLOGICAL: Single arm, open-label
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Azithromycin Intravenous Formulation Against Pelvic Inflammatory Disease (PID) In Japan
Status: COMPLETED
Conditions: Pelvic Inflammatory Disease
Interventions: DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sacral Erector Spinae Plane Block (SESPB) on Postoperative Pain and Catheter-related Bladder Discomfort
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Sacral ESP Block|PROCEDURE: Pudendal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT