pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Toca 511 & Toca FC in Patients With Recurrent High Grade Non-Muscle Invasive Bladder Cancer (Toca 8)
Status: WITHDRAWN
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: Toca 511|DRUG: Toca FC (extended-release formulation of flucytosine)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-polypectomy Surveillance Interval In High-risk Subjects After Screening Colonoscopy
Status: UNKNOWN
Conditions: Surveillance Colonoscopy
Interventions: PROCEDURE: 1) Risk of metachronous advanced neoplasia at 3-year, beyond 3 years surveillance colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy
Status: TERMINATED
Conditions: Hepatic Encephalopathy
Interventions: DRUG: Placebo|DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Hemodialysis Modality on Adiponectin,Vascular Function and Clinical Prognosis
Status: UNKNOWN
Conditions: End-Stage Renal Disease
Interventions: DEVICE: conventional artificial kidney (AK) vs. high flux AK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Radiation Therapy, Higher-Dose Radiation Therapy, or Chemotherapy in Treating Older Patients With Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: temozolomide|RADIATION: hypofractionated radiation therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: NeoAdjuvant Chemotherapy Followed by Radical Hysterectomy (OP) Versus Primary Chemo-RADiation in Cervical Cancer FIGO Stage IB2 and IIB
Status: NOT_YET_RECRUITING
Conditions: Cervical Cancer
Interventions: PROCEDURE: hysterectomy|RADIATION: Radiation|DRUG: Cisplatin|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Standardized Bereavement Intervention in Primary Care
Status: COMPLETED
Conditions: Bereavement|Grief
Interventions: BEHAVIORAL: Primary Bereavement Care|BEHAVIORAL: the current bereavement care in primary care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of NS-089/NCNP-02 in DMD
Status: ACTIVE_NOT_RECRUITING
Conditions: Duchenne Muscular Dystrophy (DMD)
Interventions: DRUG: NS-089/NCNP-02|DRUG: NS-089/NCNP-02
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STRIDES - a Clinical Research Study of an Investigational New Drug to Treat Spinocerebellar Ataxia
Status: TERMINATED
Conditions: Spinocerebellar Ataxia Type 3
Interventions: DRUG: SLS-005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Relative Bioavailability of AMG 510 Administered as Tablets and as a Water Dispersion in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: AMG 510
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Postherpetic Neuralgia
Status: COMPLETED
Conditions: Postherpetic Neuralgia
Interventions: DRUG: HSK16149 20mg BID|DRUG: HSK16149 40mg BID|DRUG: Placebo BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Aspirin in Gestation and Reproduction
Status: COMPLETED
Conditions: Birth|Spontaneous Abortion
Interventions: DRUG: acetylsalicylic-acid (aspirin)|DIETARY_SUPPLEMENT: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trental for the Treatment of Vertigo/Dizziness/Imbalance
Status: COMPLETED
Conditions: Dizziness|Vertigo
Interventions: DRUG: Pentoxifylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Exposure of Norelgestromin and Ethinyl Estradiol From Commercial Lots of EVRA (a Transdermal Contraceptive Patch Manufactured by LOHMANN Therapie-Systeme) and CILEST (an Oral Contraceptive)
Status: COMPLETED
Conditions: Contraception|Female Contraception
Interventions: DRUG: EVRA® transdermal contraceptive patch containing 6 mg of norelgestromin and 0.60 mg of ethinyl estradiol (versus CILEST® tablets).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of An Oral O1 / O139 Cholera Vaccine (Enteric Capsules)
Status: COMPLETED
Conditions: Safety of the Oral O1 / O139 Cholera Vaccine (Enteric Capsules)
Interventions: BIOLOGICAL: The oral O1 / O139 cholera vaccine (enteric capsules)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of a New Generation Botulinum Toxin A2NTX to Treat Spasticity After Stroke
Status: UNKNOWN
Conditions: Lower Limb Spasticity After Stroke
Interventions: DRUG: A2NTX|DRUG: BOTOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Lebrikizumab (LY3650150) in Moderate to Severe Atopic Dermatitis (ADvocate1)
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: Lebrikizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Effectiveness of CGB-500 Topical Ointment, 1% Tofacitinib, for the Treatment of Atopic Dermatitis
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DRUG: Tofacitinib Citrate|OTHER: placebo ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathy|Proteinuria|Oxidative Stress
Interventions: DRUG: N-acetylcysteine placebo and silibin placebo|DRUG: N-acetylcysteine active and silibin placebo|DRUG: N-acetylcysteine placebo and silibin active|DRUG: N-acetylcysteine active and silibin active|DRUG: N-acetylcysteine active + high-dose silibin active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angiotensin Converting Enzyme (ACE) Inhibition and Cardiac Allograft Vasculopathy
Status: COMPLETED
Conditions: Cardiac Allograft Vasculopathy
Interventions: DRUG: ramipril|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of a Bausch & Lomb Multipurpose Solution When Compared to Ciba Vision Aquify Multipurpose Solution
Status: COMPLETED
Conditions: Contact Lens Solutions
Interventions: DEVICE: Bausch & Lomb Multipurpose Solution - Rub Care|DEVICE: Bausch & Lomb Multipurpose Solution - No Rub Care|DEVICE: Ciba Vision Aquify Multipurpose Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy and Safety of Chlorhexidine Gluconate Chip (Periochip®) in Therapy of Symptoms in Patients With Peri-implantitis
Status: COMPLETED
Conditions: Peri-implantitis
Interventions: DRUG: Chlorhexidine 2.5 mg|DRUG: Placebo chip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series
Status: NOT_YET_RECRUITING
Conditions: Postpartum Depression
Interventions: BEHAVIORAL: interpersonal psychotherapy (IPT)|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Pancreatic Cancer|Colorectal Cancer|Rectal Cancer|Gastric Cancer|Esophageal Cancer|Gastrointestinal Stromal Tumor (GIST)
Interventions: DRUG: TGR-1202|DRUG: nab-paclitaxel + gemcitabine|DRUG: Oxaliplatin + Folinic acid + Fluorouracil|DRUG: Oxaliplatin + Folinic acid + Fluorouracil + Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture for Poststroke Patients With Shoulder Pain
Status: COMPLETED
Conditions: Stroke|Shoulder Pain|Stroke, Complication|Cerebral Infarction|Cerebral Hemorrhage
Interventions: DEVICE: electroacupuncture|DEVICE: sham electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China
Status: COMPLETED
Conditions: Lung Cancer|Small Cell Lung Cancer|Non-Small Cell Lung Cancer|Squamous Cell Carcinoma|Adenocarcinoma|Large Cell Carcinoma|Adenosquamous Carcinoma|Sarcomatoid Carcinoma|Respiratory Tract Infection|Acute Bronchitis|Pneumonia|Chronic Bronchitis|Chronic Obstructive Pulmonary Disease|Tuberculosis|Lung Neoplasm|Pulmonary Interstitial Fibrosis
Interventions: DIAGNOSTIC_TEST: Diagnostic Test: Sputum DNA methylation analysis|PROCEDURE: chest CT or pathological examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depression
Status: WITHDRAWN
Conditions: Major Depressive Disorder|Major Depressive Episode|Treatment Resistant Depression
Interventions: DRUG: botulinum toxin A|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma
Status: RECRUITING
Conditions: Myeloma
Interventions: DRUG: Belantamab mafodotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of PCV13 and Fluad in Adults Aged ≥60 Years
Status: COMPLETED
Conditions: Influenza|Streptococcus Pneumoniae
Interventions: BIOLOGICAL: Fluad and Prevenar13|BIOLOGICAL: Fluad|BIOLOGICAL: Prevenar13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: YUKON-drug-eluting Stent Below The Knee - Randomised Double-blind Study
Status: COMPLETED
Conditions: Arterial Occlusive Diseases
Interventions: DEVICE: Implantation of YUKON Sirolimus-eluting Stent|DEVICE: Implantation of YUKON Stent (uncoated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Enalapril and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients
Status: UNKNOWN
Conditions: Continuous Ambulatory Peritoneal Dialysis
Interventions: DRUG: Enalapril|DRUG: Enalapril plus Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament Reconstruction
Status: RECRUITING
Conditions: Knee Injuries
Interventions: OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Low Level Laser Treatment on Skeletal Muscle and Skin Tissue
Status: RECRUITING
Conditions: Muscles Metabolism|Skin Metabolism
Interventions: OTHER: Laser therapy|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Determine Safety and Efficacy of B244 in Subjects With Episodic Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: BIOLOGICAL: B244|BIOLOGICAL: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations
Status: COMPLETED
Conditions: Caloric Restriction|Exercise|Sleep
Interventions: DRUG: Testosterone Undecanoate|DRUG: Sesame Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Prepubertal Labial Adhesions
Status: COMPLETED
Conditions: Prepubertal Labial Adhesions
Interventions: DRUG: Estradiol cream 0.01%|DRUG: Cetaphil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medical and Psychosocial Issues in Adolescents and Young Adults With Colorectal Cancer
Status: TERMINATED
Conditions: Stage I Colorectal Cancer AJCC v8|Stage II Colorectal Cancer AJCC v8|Stage IIA Colorectal Cancer AJCC v8|Stage IIB Colorectal Cancer AJCC v8|Stage IIC Colorectal Cancer AJCC v8|Stage III Colorectal Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Medical Chart Review|OTHER: Physical Performance Testing|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Radiological Onset of Action After Treatment Initiation With Subcutaneous (SC) Natalizumab in Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Natalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Cost Effectiveness of Utilizing a Hydraulically Adjustable Walker in the Treatment of Hip Fracture
Status: WITHDRAWN
Conditions: Mobility Limitation
Interventions: DEVICE: Hydraulic Adjustable Walker|DEVICE: Conventional Walker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Using 41BB Selected Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma|Skin Cancer
Interventions: DRUG: Aldesleukin|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: 4-1BB Selected Tumor Infiltrating Lymphocytes (TIL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GM1 Prophylaxis for Post-chemotherapy Cognitive Impairment in Patients With Early Operable Breast Cancer
Status: TERMINATED
Conditions: Chemotherapy-Related Cognitive Impairment|Breast Cancer
Interventions: DRUG: Ganglioside-Monosialic Acid|DRUG: 250ml normal saline (NS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: You.Mind! | Boosting First-line Mental Health Care for Youngsters Suffering From Chronic Conditions With Mindfulness
Status: COMPLETED
Conditions: Chronic Illness
Interventions: BEHAVIORAL: Mindfulness-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hemorrhoidal Artery Ligation and Rectoanal Repair Versus Stapled Hemorrhoidopexy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemorrhoids
Interventions: PROCEDURE: Hemorrhoidal artery ligation with rectoanal repair|PROCEDURE: Stapled hemorrhoidopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of the Different Concentrations of Oral Dextrose Solution Applying With Supportive Positions on Pain During Heel-Stick Sampling in Premature Infants
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Placebo|DRUG: 10% Oral Dextrose Solution|DRUG: 20% Oral Dextrose Solution|DRUG: 30% Oral Dextrose Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First Progression
Status: WITHDRAWN
Conditions: Glioblastoma
Interventions: DRUG: Onfekafusp alfa|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Randomized, Observer-Blinded, Dose-Ranging Study in Healthy Subjects 24 to <72 Months of Age
Status: COMPLETED
Conditions: Respiratory Synctial Virus
Interventions: BIOLOGICAL: RSV F Vaccine with adjuvant (0.5mL injection)|BIOLOGICAL: RSV F Vaccine (0.5mL injection)|BIOLOGICAL: Hepatitis A Vaccine (0.5mL injection)|BIOLOGICAL: Placebo (0.5mL injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Efficacy and Safety of Regimens Containing BRII-179, BRII-835, and PEG-IFNα Treating Chronic Hepatitis B Virus (HBV) Infection (ENRICH)
Status: NOT_YET_RECRUITING
Conditions: For Treatment of Chronic Hepatitis B Virus Infection
Interventions: BIOLOGICAL: BRII-179|DRUG: BRII-835 (VIR-2218)|BIOLOGICAL: PEG-IFNα
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial to Assess Postoperative Pain After Sling Placement
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DRUG: 0.125% Marcaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MAST - Magnesium for Sickle Cell Acute Crisis in Children
Status: COMPLETED
Conditions: Anemia, Sickle Cell
Interventions: DRUG: Magnesium Sulfate|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SL-401 as Consolidation Therapy in Patients With Adverse Risk Acute Myeloid Leukemia in First Complete Remission
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Tagraxofusp-erzs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Blood Glucose Monitoring Systems
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Contour® NEXT LINK BGMS|DEVICE: OneTouch® UltraLink® BGMS|DEVICE: Nova Max Link® BGMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Trial to Evaluate the Sufentanil NanoTab® PCA System/15 mcg (Zalviso™) for Post-Operative Pain in Patients After Knee or Hip Replacement Surgery
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: DRUG: Sufentanil NanoTab PCA System/15 mcg|DRUG: Placebo Sufentanil NanoTab PCA System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Effect on Mitochondrial Function
Status: UNKNOWN
Conditions: Complication of Anesthesia|Ischaemia-reperfusion Injury
Interventions: DRUG: Dexmedetomidine|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Erector Spinae Plane Block for Rib Fracture Analgesia in the Emergency Department
Status: UNKNOWN
Conditions: Rib Fracture Multiple
Interventions: PROCEDURE: Erector Spinae Plane Block|DRUG: IV Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Automated Mononuclear Collection Systems in Patients Undergoing Extracorporeal Photochemotherapy. A Cross-over Equivalence Study. (MNC_CMNC)
Status: COMPLETED
Conditions: GvHD|Lung Graft Dysfunction
Interventions: DEVICE: Spectra Optia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Modified Twin Block in Skeletal Class II Growing Females With Mandibular Deficiency
Status: UNKNOWN
Conditions: Class II Division 1 Malocclusion
Interventions: DEVICE: twin block appliance|DEVICE: modified twin block appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TeleLifestyleCoaching for Weight Loss
Status: COMPLETED
Conditions: Overweight
Interventions: DEVICE: telemedical devices (weighing machine and step counter)|BEHAVIORAL: care calls once per week for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Screening for Stomach Diseases and Colorectal Neoplasms With the Fecal Testing
Status: UNKNOWN
Conditions: Colorectal Cancer|Stomach Disease
Interventions: OTHER: FIT(Eiken OC-Sensor) Two-day sampling|OTHER: FIT(Eiken OC-Sensor) One-year interval|OTHER: FIT(Eiken OC-Sensor) One-day sampling|OTHER: FIT(Eiken OC-Sensor) Two-year interval|OTHER: HpSA (Firstep Helicobacter pylori Antigen Rapid Test)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma
Status: COMPLETED
Conditions: Melasma
Interventions: DRUG: Tranexamic Acid Oral Product|DRUG: Hydroquinone 4% Cream|OTHER: Sunscreen|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bariatric Embolization Before Sleeve Gastrectomy for Super Obese Patients
Status: RECRUITING
Conditions: Sleeve Gastrectomy|Morbid Obesity|Bariatric Surgery
Interventions: PROCEDURE: bariatric embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sputum Clearance Effects of Hypertonic Saline in Non-cystic Fibrosis Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: OTHER: Hypertonic saline solution|OTHER: Hyaneb solution|OTHER: Isotonic saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Additional Study of NPC-22 in Healthy Adult Males
Status: COMPLETED
Conditions: Safety and Pharmacokinetics
Interventions: DRUG: NPC-22|DRUG: NPC-22|DRUG: NPC-22 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autologous Blood Transfusion After Local Infiltration
Status: COMPLETED
Conditions: Total Hip Arthroplasty|Total Knee Arthroplasty
Interventions: DRUG: Autologous blood transfusion with ropivacaine|DRUG: Autologous blood transfusion with ropivacaine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Randomized Study on Locally Advanced NSCLC Escalated Dose on Individual Basis Treatment With Radiochemotherapy
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Locally Advanced Disease
Interventions: RADIATION: Standard radiochemotherapy to 68 Gy|RADIATION: Dose escalated radiochemotherapy up to 84 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Psychological Interventions on Psychometric and Immunological Measures in Patients With Major Depression
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: CBT - active|BEHAVIORAL: CBT - euthymic|BEHAVIORAL: CBASP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Doses of Sitagliptin (MK-0431) in Participants With Type 2 Diabetes Mellitus (MK-0431-014)
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Placebo to sitagliptin|DRUG: Metformin|DRUG: Rescue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab, Capecitabine, and Radiation Therapy in Treating Patients With Mismatch-Repair Deficient and Epstein-Barr Virus Positive Gastric Cancer
Status: RECRUITING
Conditions: Epstein-Barr Virus Positive|Gastric Adenocarcinoma|Mismatch Repair Protein Deficiency|Stage IB Gastric Cancer AJCC v7|Stage II Gastric Cancer AJCC v7|Stage IIA Gastric Cancer AJCC v7|Stage IIB Gastric Cancer AJCC v7|Stage III Gastric Cancer AJCC v7|Stage IIIA Gastric Cancer AJCC v7|Stage IIIB Gastric Cancer AJCC v7|Stage IIIC Gastric Cancer AJCC v7
Interventions: DRUG: Capecitabine|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: USTekinumab in Fistulising Perianal Crohn's Disease (USTAP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Ustekinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures
Status: TERMINATED
Conditions: Supracondylar Humerus Fracture
Interventions: DRUG: Acetaminophen-Hydrocodone|DRUG: Acetaminophen and Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adolescent and Adult Subjects With Asthma and Seasonal Allergic Rhinitis Receiving Advair Diskus or Placebo
Status: WITHDRAWN
Conditions: Asthma|Seasonal Allergic Rhinitis
Interventions: DRUG: Adding Advair Diskus 100/50mcg (FSC) BID and Singulair 10mg is added to placebo Diskus BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Hormone Replacement Therapy on the Serotonergic System and Mood in Postmenopausal Women
Status: COMPLETED
Conditions: Hormone Replacement
Interventions: DRUG: estradiol valerate|DRUG: micronized progesterone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anterior and Posterior Decompression Surgery in Individuals With Cervical Radiculopathy and Headache
Status: COMPLETED
Conditions: Cervical Radiculopathy
Interventions: PROCEDURE: Anterior cervical decompression surgery|PROCEDURE: Posterior cervical foraminotomy with or without laminectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Utility of Bone Grafts in Open Wedge Corrective Osteotomy and Plate Fixation
Status: RECRUITING
Conditions: Malunion of Fracture of Radius
Interventions: PROCEDURE: Group without bone grafting|PROCEDURE: Group with bone grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
Status: RECRUITING
Conditions: Mental Health|Child Wellbeing|Infant Health|Child Health|Reproductive Health|Healthy Aging|Health Equity|Quality of Life|Social Determinants of Health|Environmental Exposure|Genetics|Cognition|Learning|Child Development|Congenital Abnormalities|Disability|Injuries|Communicable Diseases|Noncommunicable Diseases|Physical Fitness|Diet|Obesity|Allergy and Immunology|Inflammation|Intergenerational Relations
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pyrimethamine for the Treatment of Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Leukemia
Interventions: DRUG: pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Integrated Closed-loop Feedback System for Pediatric Cardiometabolic Disease
Status: UNKNOWN
Conditions: Obesity|Health Behavior
Interventions: BEHAVIORAL: mHealth wristband|BEHAVIORAL: mHealth scale|BEHAVIORAL: EMA|BEHAVIORAL: mHealth app|BEHAVIORAL: Health Behavior Feedback|BEHAVIORAL: Integrated closed-loop feedback system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Urinary 5-HIAA for Diagnosis of Acute Appendicitis in Children, Does it Help?
Status: COMPLETED
Conditions: Diagnosis of Acute Appendicitis in Children
Interventions: DIAGNOSTIC_TEST: measurement of urinary 5-HIAA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex
Status: TERMINATED
Conditions: Angiofibroma of Face|Tuberous Sclerosis
Interventions: DRUG: Sirolimus 0.2%|DRUG: Sirolimus 0.4%|DRUG: Placebo ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community-Based Physical Activity Intervention for Underserved Cancer Survivors
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Exercise Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)
Status: COMPLETED
Conditions: Alzheimer's Dementia|Parkinson Disease(PD)|Fronto-Temporal Dementia
Interventions: OTHER: No intervention. Only survey and normal use of eye-tracking
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Capecitabine Versus S-1 in Elderly Advanced Gastric Cancer (AGC): Randomized Trial
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: S-1|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Effects of Endothelium-Derived Versus Hemoglobin-Transported Nitric Oxide in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus|Healthy|Hypercholesterolemia|Hypertension
Interventions: PROCEDURE: hemoglobin-transported nitric oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Randomised Study Comparing Tissue Conservation in Conventional Versus Mohs' Surgery of Basal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Basal Cell
Interventions: PROCEDURE: standard surgery|PROCEDURE: Mohs micrographic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Pharmacokinetics, Safety, and Tolerability of Intravenous ETX2514 and Sulbactam Administered Concurrently to Subjects With Various Degrees of Renal Impairment and Healthy Matched Control Subjects
Status: COMPLETED
Conditions: Acinetobacter Baumannii Infection
Interventions: DRUG: ETX2514SUL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Preventing HPV in HIV-Positive Women in India
Status: COMPLETED
Conditions: Cervical Cancer|Nonneoplastic Condition|Precancerous Condition
Interventions: BIOLOGICAL: quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine|GENETIC: DNA analysis|GENETIC: polymerase chain reaction|OTHER: cytology specimen collection procedure|PROCEDURE: colposcopic biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Injection-Assisted Cold Snare Polypectomy Versus Endoscopic Mucosal Resection for Small Colorectal Polyps
Status: COMPLETED
Conditions: Colonic Polyps
Interventions: PROCEDURE: Injection-assisted Cold Snare Polypectomy|PROCEDURE: Endoscopic Mucosal Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RO4929097 Before Surgery in Treating Patients With Pancreatic Cancer
Status: TERMINATED
Conditions: Adenocarcinoma of the Pancreas|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer
Interventions: DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Solid Neoplasm|Bladder Carcinoma|Colon Carcinoma|Estrogen Receptor Negative|Head and Neck Squamous Cell Carcinoma|Hepatocellular Carcinoma|HER2/Neu Negative|Melanoma|Non-Small Cell Lung Carcinoma|Pancreatic Carcinoma|Progesterone Receptor Negative|Rectal Carcinoma|Renal Cell Carcinoma|Soft Tissue Sarcoma|Triple-Negative Breast Carcinoma|TP53 Gene Mutation|Unresectable Solid Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Modified Vaccinia Virus Ankara Vaccine Expressing p53|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surufatinib Combined With TAS-102 in Third-line and Later-line Therapy of Patients With Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Neoplasms
Interventions: DRUG: Surufatinib|DRUG: TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis
Status: COMPLETED
Conditions: Relationship Between the Exposure of Glucocorticoids During Pregnancy and Orofacial Cleft Development
Interventions: DRUG: Diflucortolone valerate (BAY866146)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Noninvasive Peripheral Nerve Stimulation for Medication-Naive and Medication-Refractory RLS
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DEVICE: NTX100 Neuromodulation System - Active|DEVICE: NTX100 Neuromodulation System - Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Canagliflozin (Invokana™) vs. Standard Dual Therapy Regimen for T2DM During Ramadan
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Canagliflozin|DRUG: Repaglinide|DRUG: Pioglitazone|DRUG: Gliclazide|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Diabetes and Hypertension
Status: TERMINATED
Conditions: Diabetes Mellitus|Hypertension
Interventions: BEHAVIORAL: Diet|BEHAVIORAL: Moderate exercise|DRUG: enalapril tablets|DRUG: placebo tablets|DRUG: Losartan Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study on the Effect of CPAP on AF Recurrence After Catheter Ablation in Patients With AF and OSA
Status: RECRUITING
Conditions: Atrial Fibrillation|Continuous Positive Airway Pressure|Obstructive Sleep Apnea|Recurrence|Observational Study
Interventions: DEVICE: CPAP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PERC Health Canada COVID-19
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: DIAGNOSTIC_TEST: Buccal Swabc- Copan flocked swab|DIAGNOSTIC_TEST: Standard of Care COVID-19 swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rhopressa for Corneal Edema Associated With Fuchs Dystrophy
Status: COMPLETED
Conditions: Fuchs Endothelial Dystrophy
Interventions: DRUG: Netarsudil Ophthalmic Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of 4-week Oral Administration of a Fermented Dairy Product Containing Lactobacillus Rhamnosus CNCM I-3690, on Subjective State Anxiety Levels in Healthy Women Undergoing Academic Stress.
Status: COMPLETED
Conditions: Anxious Healthy Subjects
Interventions: OTHER: Milk product fermented by lactic bacteria or not fermented
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study.
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Verapamil and Magnesium Sulfate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Apatinib Plus Concurrent Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: COMBINATION_PRODUCT: Apatinib,Paclitaxel,Cisplatin,RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Stimulation and Robotics in Chronic Stroke Motor Recovery
Status: COMPLETED
Conditions: Chronic Stroke
Interventions: DEVICE: Transcranial direct current stimulation|DEVICE: Upper extremity robotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Difference of Gastric Microbiota in the Process of Correa's Model.
Status: UNKNOWN
Conditions: Gastric Microbiota|Non-atrophic Gastritis|Atrophic Gastritis|Intestinal Metaplasia|Intraepithelial Neoplasia|Gastric Cancer|Helicobacter Pylori
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of a Local Vitamin-C Rich Fruit (Guava) in Improving Iron Absorption From Mungbean Based Meals and Its Effect on Iron Status of Rural Indian Children (6-10 Years)
Status: COMPLETED
Conditions: Iron Deficiency|Anemia
Interventions: OTHER: Mung Bean Meal|OTHER: Guava
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Resveratrol and Lipoic Acid Transdermal Patch for Lipolysis in Overweight Volunteers
Status: COMPLETED
Conditions: Lipolysis
Interventions: OTHER: Resveratrol lipoic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare Immunogenicity & Safety of 2 Formulations of GSK Biologicals' DTPa-HBV-IPV/Hib Vaccine Given in Healthy Infants
Status: COMPLETED
Conditions: Diphtheria|Hepatitis B|Poliomyelitis|Tetanus|Acellular Pertussis
Interventions: BIOLOGICAL: DTPa-HBV-IPV/Hib vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: An Investigational Immuno-therapy Study of Ulocuplumab in Combination With Low Dose Cytarabine in Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: BMS-936564|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shared Decision Making With Anal Cancer Patients on Radiation Dose
Status: ACTIVE_NOT_RECRUITING
Conditions: Anal Cancer
Interventions: RADIATION: 2.15 gray and 1.8 gray. Max. 6 weeks.|RADIATION: 2.15 gray and 1.8 gray. Max. 5 weeks.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country
Status: UNKNOWN
Conditions: Gestational Diabetes|Type 2 Diabetes|Pregnancy
Interventions: DRUG: Metformin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bridge-Enhanced ACL Repair (BEAR) in Meniscus Repair
Status: NOT_YET_RECRUITING
Conditions: Meniscus Tear
Interventions: PROCEDURE: Meniscal Repair Procedure|DEVICE: BEAR Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence Self Harm Application
Status: NOT_YET_RECRUITING
Conditions: Self-harm|Suicide
Interventions: BEHAVIORAL: The Artificial Intelligence intervention for Self-Harm prevention Application (AISHA) is a mobile intervention based on Y-CMAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pembrolizumab After Radiation Therapy in Treating Patients With Pleural Malignant Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Pleural Malignant Mesothelioma
Interventions: OTHER: Laboratory Biomarker Analysis|RADIATION: Palliative Radiation Therapy|BIOLOGICAL: Pembrolizumab|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Dasatinib (Sprycel) in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Status: TERMINATED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Global Hip Versus Isolated Abductors Strengthening Exercises in Patients Withsecondary Piriformis Syndrome
Status: COMPLETED
Conditions: Piriformis Syndrome
Interventions: OTHER: Global hip muscles strengthening exercises|OTHER: Hip abductors strengthening exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT