pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis
Status: COMPLETED
Conditions: Seborrheic Keratosis
Interventions: DRUG: A-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single-dose, Two-way Crossover Bioequivalence of Lamotrigine in Healthy Male Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: Lamotrigine 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Short-term Intensive De-escalation Therapy on Long-term Regimen Simplification
Status: UNKNOWN
Conditions: Diabetes type2
Interventions: DRUG: CSII and thereafter combination therapy, followed up with wearable devices|DRUG: CSII and thereafter combination therapy, followed up in traditional ways|DRUG: Traditionally upgrading therapy, followed up in traditional ways
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0980|DRUG: GDC-0980|DRUG: GDC-0980|DRUG: GDC-0980|DRUG: GDC-0980|DRUG: GDC-0980|DRUG: rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot of an Outpatient Regimen of Medical Abortion With Mifepristone and Sublingual Misoprostol in the 11 and 12 Weeks
Status: COMPLETED
Conditions: Abortion, 3 Months
Interventions: DRUG: Mifepristone|DRUG: Sublingual misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Skin Prick Testing and Intradermal Skin Test Result of Local and Imported Insect Allergen Extracts
Status: COMPLETED
Conditions: Allergy to Arthropod Sting
Interventions: DIAGNOSTIC_TEST: Local insect allergen extracts skin test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Psychosocial Characteristics and Non-pharmacological Intervention of Patients With Treatment-resistant Depression
Status: COMPLETED
Conditions: Treatment-resistant Depression
Interventions: BEHAVIORAL: Nurse-led cognitive-behavioral-based group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HMPL-760 Safety and Tolerability Study in Patients With Previously Treated CLL/SLL or NHL
Status: WITHDRAWN
Conditions: CLL/SLL|NHL|MCL|MZL|Lymphoplasmacytic Lymphoma|Waldenstrom Macroglobulinemia|Follicular Lymphoma|DLBCL|Richter Syndrome
Interventions: DRUG: HMPL-760
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dacomitinib Treatment Followed by 3rd Generation EGFR-TKI in Patients With EGFR Mutation Positive Advanced NSCLC
Status: RECRUITING
Conditions: EGFR Activating Mutation|NSCLC Stage IV|NSCLC Stage IIIB|NSCLC, Recurrent
Interventions: DRUG: Dacomitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EC-104 Intravitreal Implant for the Treatment of Diabetic Macular Edema
Status: NOT_YET_RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: EC-104 high dose|DRUG: EC-104 low dose|DRUG: Dexamethasone intravitreal implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therapy in South Africa
Status: COMPLETED
Conditions: HIV/AIDS|Depression|Chronic Diseases of Lifestyle
Interventions: OTHER: Primary care 101 plus mental health|OTHER: Standard Primary Care 101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Impact of Free Fatty Acid Reduction on Vascular Function in the Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: acipimox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bevacizumab in Extensive Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Standard Chemotherapy (PCDE or PE)|DRUG: Experimental Treatment (PCDE or PE + bevacizumab)|DRUG: Prerandomization Chemotherapy (PCDE or PE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cueing and Pilates in Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Pilates Exercise|Pilates, Core Stability|Mind-body Exercise
Interventions: OTHER: Pilates with cueing|OTHER: Pilates without cueing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Local Anesthetic Block: Thoracolumbar Interfascial Plane
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Thoracolumbar Interfascial Plane Block|DRUG: Ropivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement
Status: RECRUITING
Conditions: Hemodynamics|Transcatheter Aortic Valve Replacement|General Anesthesia|Post-induction Hypotension
Interventions: DRUG: ciprofol|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Convalescent Plasma as a Possible Treatment for COVID-19
Status: RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Convalescent plasma|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tris-CAR-T Cell Therapy for Recurrent Glioblastoma
Status: RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: GENETIC: Inverse correlated dual-target, truncated IL7Ra modified CAR -expressing autologous T-lymphocytes.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement in Wound Healing With Negative Pressure Wound Therapy for Postoperative Total Hip Arthroplasty
Status: TERMINATED
Conditions: Complications; Arthroplasty, Infection or Inflammation|Wound Complication
Interventions: DEVICE: PREVENA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Sterol Enhanced Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DIETARY_SUPPLEMENT: phytosterol enhanced soy based beverage|DIETARY_SUPPLEMENT: 1% milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing CoQ10 Levels While Taking 3 Different Statins
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Pitavastin 4mg|DRUG: Atorvastatin 20mg|DRUG: Rosuvastatin 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Carotid Stenting Boston Scientific Surveillance Program
Status: COMPLETED
Conditions: Carotid Artery Disease
Interventions: DEVICE: Carotid WALLSTENT Monorail Endoprosthesis|DEVICE: FilterWire EZ™ System™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in ISIS 396443-CS2 (NCT01703988) or ISIS 396443-CS10 (NCT01780246)
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Erector Spinae Plane Block for Postoperative Analgesia in Adult Patients Undergoing Thoracoscopy
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: No injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Functional Status on 30-day Resource Utilization and Organ System Complications Following Bariatric Surgery
Status: COMPLETED
Conditions: Dependence|Perioperative/Postoperative Complications|Frailty
Interventions: PROCEDURE: Bariatric surgery|DRUG: General anesthetic|DEVICE: Indeterminate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Retrospective Clinical Study of Apatinib in Combination With Radiotherapy / Chemotherapy Second-line and Above in the Treatment of Recurrent / Metastatic Head and Neck Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Apatinib plus chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Short-Term Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Exenatide|DRUG: Humulin-N
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avoidable Mortality Case Note Review Trial
Status: UNKNOWN
Conditions: In Hospital Mortality
Interventions: OTHER: Explicit case note review checklist (nurse)|OTHER: Explicit case note review checklist (physician)|OTHER: Explicit case note review checklist (MDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Alpha Radiation Emitters Device for the Treatment of Liver Metastases (DaRT)
Status: RECRUITING
Conditions: Liver Metastases
Interventions: DEVICE: Diffusing Alpha Radiation Emitters Therapy (DaRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess Safety, Tolerability, and Immunogenicity of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold-Adapted (FluMist) and Measles, Mumps, Rubella, and Varicella Vaccines Administered Concurrently to Healthy Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: FluMist|BIOLOGICAL: FluMist|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: TreadWill, an Automated Intervention for Depressive Symptoms
Status: UNKNOWN
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Interactive and full-featured intervention|BEHAVIORAL: Feature-limited CCBT|OTHER: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck|Recurrent Head and Neck Squamous Cell Carcinoma|Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Oral Cavity Squamous Cell Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Recurrent Paranasal Sinus Squamous Cell Carcinoma|Recurrent Salivary Gland Carcinoma|Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Major Salivary Gland Cancer AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage III Sinonasal Cancer AJCC v8|Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage IV Hypopharyngeal Carcinoma AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IV Lip and Oral Cavity Cancer AJCC v8|Stage IV Major Salivary Gland Cancer AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IV Sinonasal Cancer AJCC v8|Unresectable Cutaneous Squamous Cell Carcinoma of the Head and Neck|Unresectable Head and Neck Squamous Cell Carcinoma|Unresectable Hypopharyngeal Squamous Cell Carcinoma|Unresectable Laryngeal Squamous Cell Carcinoma|Unresectable Oral Cavity Squamous Cell Carcinoma|Unresectable Oropharyngeal Squamous Cell Carcinoma|Unresectable Paranasal Sinus Squamous Cell Carcinoma|Unresectable Salivary Gland Squamous Cell Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Elimusertib|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography|OTHER: Quality-of-Life Assessment|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomics of the Variability in the In Vivo Response to Glucocorticoids
Status: COMPLETED
Conditions: Glucocorticoids Toxicity|Glucose Intolerance
Interventions: DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Validation of FDG-PET Segmentation Tools for Tumor Delineation by Correlation of CT- and FDG-PET Volume Measurements With Histopathology of Nodal Metastases of Head and Neck Carcinomas.
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: OTHER: CT-FDG/PET scan of the head-and-neck region
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH)
Status: NOT_YET_RECRUITING
Conditions: Hemophagocytic Lymphohistiocytoses
Interventions: DRUG: Ruxolitinib|DRUG: Etoposide|DRUG: Dexamethasone|PROCEDURE: Non-interventional Imaging|PROCEDURE: Research Biopsy|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Trial of the Group A and C Meningococcal Polysaccharide Vaccine
Status: UNKNOWN
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: Experimental Group A and C meningococcal polysaccharide vaccine|BIOLOGICAL: Control Group A and C meningococcal polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Of Oral PHA-848125AC In Patients With Malignant Thymoma Previously Treated With Multiple Lines Of Chemotherapy
Status: TERMINATED
Conditions: Malignant Thymoma
Interventions: DRUG: Milciclib Maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tivantinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Childhood Solid Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Tivantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fatigue in Patients With Amyotrophic Lateral Sclerosis
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis|Dysphagia|Dyspnea|Respiration Disorders
Interventions: DEVICE: Experimental expiratory muscle strength training (EMST)|DEVICE: Sham expiratory muscle strength training (EMST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Oculusgen (Ologen) Collagen Matrix Implant for Phaco-Trabeculectomy in Primary Glaucoma: A Case-Control Study
Status: UNKNOWN
Conditions: Cataract|Glaucoma
Interventions: DEVICE: ologen™ Collagen Matrix Implant as an aid in phacotrabeculectomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Family Collaborative Physiotherapy Programs With High-risk Infants
Status: COMPLETED
Conditions: Cerebral Palsy|Infant, Newborn, Disease|Infant, Small for Gestational Age|Infant Asphyxia|Infant, Very Low Birth Weight|Infant of Diabetic Mother|Infant, Premature, Diseases|Infant Development
Interventions: OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular and InflammAging Study
Status: RECRUITING
Conditions: Aging|Cardiovascular Diseases|Overweight or Obesity
Interventions: DIETARY_SUPPLEMENT: Juice Plus+ Fruit, Vegetable and Berry blends|DIETARY_SUPPLEMENT: Juice Plus+ Omega blend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of a Lumbar Rotational Spinal Mobilization Technique With Lumbar Disc Herniation
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: The Lumbar Rotational Spinal Mobilization Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MS-275 and Isotretinoin in Treating Patients With Metastatic or Advanced Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Adult Grade III Lymphomatoid Granulomatosis|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Primary Central Nervous System Non-Hodgkin Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Mixed Cell Lymphoma|Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Adult T-cell Leukemia/Lymphoma|Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma|Stage IV Marginal Zone Lymphoma|Stage IV Mycosis Fungoides/Sezary Syndrome|Stage IV Small Lymphocytic Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: DRUG: entinostat|DRUG: isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of TBI-1501 for Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoblastic Leukemia, Acute Adult
Interventions: BIOLOGICAL: TBI-1501
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia
Status: WITHDRAWN
Conditions: Patients With "ASA 3" Designation
Interventions: DRUG: Propofol|DRUG: Propofol-Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Effectiveness of Erector Spinae Plane Block in Peri-operative Analgesia for Laparoscopic Nephrectomy/Nephron Sparing Surgery (NSS)/Hynes-Anderson Procedures.
Status: COMPLETED
Conditions: Erector Spinae Plane Block
Interventions: PROCEDURE: bilateral ESP block with 0,25% Bupivacaine+ Adrenaline|PROCEDURE: ESP block continuous infusion with 0,125% Bupivacaine+Adrenaline|DRUG: Morphine PCA pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparaison of Two Prone Position Techniques on Occurence of Pressure Sores in ICU
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Pressure Ulcers Stage III
Interventions: OTHER: Swimmer Prone Position|OTHER: Prone position with arms alongside the body
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Sacituzumab Govitecan-hziy (IMMU-132) Versus Treatment of Physician's Choice in Participants With Metastatic or Locally Advanced Unresectable Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic Unresectable Urothelial Cancer
Interventions: DRUG: Sacituzumab Govitecan-hziy|DRUG: Paclitaxel|DRUG: Docetaxel|DRUG: Vinflunine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection in Chinese Participants With Acute Gout
Status: NOT_YET_RECRUITING
Conditions: Acute Gout
Interventions: DRUG: Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection 200 mg|OTHER: Placebo|DRUG: Compound Betamethasone Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With CS-1008 to Treat Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer Stage IIIC|Ovarian Cancer Stage IV
Interventions: DRUG: CS-1008|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Laparoscopic Proximal Gastrectomy Based on PTST(Parachute-tunnel- Style Technique) Esophagogastric Anastomose.
Status: ENROLLING_BY_INVITATION
Conditions: Gastroesophageal-junction Cancer|Proximal Gastrectomy|Gastroesophagostomy
Interventions: PROCEDURE: PTST(parachute-tunnel-style technique)for esophagogastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Propofol Target Controlled Infusion (TCI) and Sevoflurane
Status: COMPLETED
Conditions: Vitreous Detachment
Interventions: PROCEDURE: TCI Propofol|PROCEDURE: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Safety and Efficacy of Albiglutide Administered in Combination With Insulin Glargine
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BIOLOGICAL: albiglutide + insulin glargine|DRUG: insulin glargine + preprandial lispro insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Karenitecin (BNP1350) to Treat Malignant Melanoma
Status: COMPLETED
Conditions: Melanoma|Neoplasm
Interventions: DRUG: Karenitecin (BNP1350)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Basket Study of Pyrotinib Maleate Tablets in HER2 Mutated or Amplified of Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumor
Interventions: DRUG: Pyrotinib Maleate|OTHER: standard regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Androgen Suppression Plus Radiation Therapy for High-Risk Localized Adenocarcinoma Prostate
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Prostate
Interventions: RADIATION: Androgen suppression plus radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis
Status: COMPLETED
Conditions: Anemia, Sickle Cell|Pain
Interventions: DRUG: Fentanyl Citrate|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trendelenburg, Abdominal Insufflation and Time to Completion of Cystoscopy
Status: RECRUITING
Conditions: Bladder Integrity|Bladder Function|Ureteral Integrity|Ureteral Function
Interventions: OTHER: Flat position|OTHER: Trendelenburg position|DEVICE: Insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Refractory Chronic Cough
Status: COMPLETED
Conditions: Refractory Chronic Cough
Interventions: DRUG: 5 mg Serlopitant Tablets|DRUG: Matching Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromonitoring During Rapid Ventricular Pacing in Patients Undergoing Cerebral Aneurysm Surgery
Status: COMPLETED
Conditions: Cerebral Arterial Aneurysm|Ventricular Rate Response Pacing
Interventions: OTHER: rapid ventricular pacing|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RAPP- Systematic E-assessment of Postoperative Recovery in Patients Undergoing Day Surgery
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: DEVICE: Smartphone app Recovery Assessment by Phone Points (RAPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Feasibility of a Physical Activity Intervention for Advanced Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma|Hematologic Neoplasms|Advanced Cancer
Interventions: BEHAVIORAL: Physical Activity for Advanced Cancer Treatment (PAACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ketamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
Status: COMPLETED
Conditions: Tetralogy of Fallot With Pulmonary Stenosis
Interventions: OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A COMPARISON OF TRANSDERMAL DICLOFENAC AND ORAL COMBINATION OF PARACETAMOL AND IBUPROFEN IN POSTOPERATIVE PAIN MANAGEMENT FOLLOWING SURGICAL EXTRACTION OF MANDIBULAR THIRD MOLAR- A RANDOMISD CONTROLLED TRIALS.
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Oral tablet and transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops
Status: COMPLETED
Conditions: Glaucoma|Intraocular Pressure|Anesthesia
Interventions: DRUG: Tono-pen XL Applanation tonometer + Ocu-film +
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Effect of Intramuscular Ephedrine on the Incidence of Nausea and Vomiting During Elective Cesarean Section
Status: COMPLETED
Conditions: Nausea|Vomiting|Cesarean Section
Interventions: DRUG: Ephedrine [Synonyms: Ephedra, Ephedrinum]|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of ALTENS in Improving Dysphagia Induced by IMRT for Head and Neck Cancers
Status: UNKNOWN
Conditions: Head and Neck Cancer|Dysphagia
Interventions: DEVICE: Codetron ALTENS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pirfenidone Combined With Standard First-Line Chemotherapy in Advanced-Stage Lung NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Non Small Cell Lung Cancer|Advanced Cancer|Metastatic Lung Cancer|Squamous Cell Lung Cancer|Non-Squamous Non-Small Cell Neoplasm of Lung
Interventions: DRUG: Pirfenidone|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial)
Status: WITHDRAWN
Conditions: Mild Traumatic Brain Injury
Interventions: DEVICE: Active CN-NINM PoNS|DEVICE: Sham CN-NINM PoNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Reliability and Validity of the Modified Manual Muscle Test for Persons With MS
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: Modified Manual Muscle Test|DIAGNOSTIC_TEST: BMRC manual muscle test|DIAGNOSTIC_TEST: MicroFET2 handhold dynamometer|DIAGNOSTIC_TEST: Modified Tardieu Scale|DIAGNOSTIC_TEST: Fatigue Scale for Motor and Cognitive Functions|DIAGNOSTIC_TEST: numeric rating scale Fatigue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Low-protein Rice on Nutritional Status and Other Outcomes of Patients With Chronic Kidney Disease.(KS01)
Status: COMPLETED
Conditions: Chronic Kidney Disease (CKD)
Interventions: DIETARY_SUPPLEMENT: Low Protein Rice MATSUBUMAI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RCT for the Efficacy of Soothing Cream Jel in Improving Upper Limb Pain and Motion
Status: RECRUITING
Conditions: Upper Extremity Problem
Interventions: DRUG: SJC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection
Status: TERMINATED
Conditions: Non-erosive Reflux Disease|Gastroesophageal Reflux
Interventions: DRUG: Proton Pump Inhibitor (PPI) Therapy|DRUG: Sucralfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of ACS in Twin With LPB: Study Protocol for a RCT
Status: COMPLETED
Conditions: Twin Pregnancy, Antepartum Condition or Complication
Interventions: DRUG: Betamethason Sodium Phosphate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vitamin D Requirements During Pregnancy
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: cholecalciferol (vitamin D3)|DRUG: cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioral Therapy (CBT) for Posttraumatic Stress Disorder (PTSD) in Community Addiction Treatment
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Substance-Related Disorders
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Individual Addiction Counseling|BEHAVIORAL: Treatment-as-usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy
Status: RECRUITING
Conditions: Pancreatic Cancer|Liver Metastases|Surgery
Interventions: PROCEDURE: Synchronous resection of primary pancreatic cancer and liver oligometastasis|DRUG: Standard chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated LocoRegional Radiotherapy in Breast Cancer
Status: RECRUITING
Conditions: Breast Neoplasms|Radiotherapy|Lymphedema
Interventions: RADIATION: Locoregional radiation treatment - Conventional fractionation|RADIATION: Locoregional radiation treatment - Hypofractionation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children
Status: COMPLETED
Conditions: Hernia, Inguinal|Hydrocele
Interventions: DRUG: clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy, Safety and Pharmacokinetics Study of Beloranib (ZGN-440 for Injectable Suspension) in Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Beloranib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: PROCEDURE: skin biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery
Status: COMPLETED
Conditions: Brain Injury|Myocardial Injury
Interventions: DEVICE: Hyperbaric oxygen pretreatment (GR2200)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Osteopathic Manual Therapy on Vascular Supply
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Osteopathic evaluation|OTHER: Osteopathic evaluation with treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Inhibitor Based Induction Chemotherapy Followed by De-escalation Protocols in OPSCC
Status: RECRUITING
Conditions: Oropharyngeal Cancer
Interventions: PROCEDURE: Toxicities reduced treatment|PROCEDURE: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Posthospital Medication Management of Older Adults Through Health IT
Status: COMPLETED
Conditions: Adverse Outcomes Post-hospital Discharge
Interventions: OTHER: Electronic delivery of enhanced discharge information to the ambulatory physician|OTHER: Electronic delivery of enhanced discharge information to the ambulatory physician|OTHER: Electronic delivery of enhanced discharge information to the ambulatory physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator
Status: COMPLETED
Conditions: Maternal; Chorioamnionitis, Affecting Fetus|Early-Onset Sepses, Neonatal
Interventions: DIAGNOSTIC_TEST: EOS Calculator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Epidural Labor Pain Relief Techniques on Maternal and Fetal Outcomes
Status: COMPLETED
Conditions: Laboring Women Requesting Neuraxial Labor Analgesia
Interventions: PROCEDURE: Epidural Technique versus Dural Puncture Epidural Technique versus Combined Spinal Epidural Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy of Shunt Operation for Idiopathic Normal Pressure Hydrocephalus
Status: COMPLETED
Conditions: Idiopathic Normal Pressure Hydrocephalus
Interventions: PROCEDURE: ventriculo-peritoneal shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Drug Delivery System in Glaucoma
Status: COMPLETED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: High Dose Drug Device|DRUG: Low Dose Drug Device|DRUG: Placebo Device|DRUG: bimatoprost 0.03%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Patterned Oral Somatosensory Entrainment for Shortening Time to Oral Feeding
Status: UNKNOWN
Conditions: Infant, Extremely Premature|Length of Stay|Feeding
Interventions: DEVICE: NTrainer® Intervention|DEVICE: Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety and Immunogenicity of Norovirus Bivalent Vaccine
Status: COMPLETED
Conditions: Norwalk Gastroenteritis|Norovirus Infections
Interventions: BIOLOGICAL: Norovirus Bivalent (GI.1 / GII.4) Vaccine（low）|BIOLOGICAL: Norovirus Bivalent (GI.1 / GII.4) Vaccine（middle）|BIOLOGICAL: Norovirus Bivalent (GI.1 / GII.4) Vaccine（high）|BIOLOGICAL: Normal saline|BIOLOGICAL: Aluminum adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Integrating Insulin Delivery and Glucose Sensing in Subcutaneous Tissue for the Treatment of Type-1 Diabetic Patients
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: PROCEDURE: OGTT and CLAMP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reassessment of Premedication in Surgery
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: Zopiclone|DRUG: Alprazolam|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Cohort Prospective Study of Predictors Influencing the Quality of Visualization of the Operating Field During Orthognathic Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Malocclusion|Maxillofacial Injuries|Orthodontics|Hemorrhage
Interventions: DRUG: Nitroglycerin solution|DEVICE: monitoring of cerebral oxygen saturation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Osteoporosis: Effects of Mini-trampoline Training on the Bone Remodeling
Status: COMPLETED
Conditions: Perimenopausal Bone Loss|Postmenopausal Osteopenia
Interventions: OTHER: physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treat Malignant Ascites Caused by Gastrointestinal or Ovarian Cancer With M701 Bispecific Antibody
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Ascites
Interventions: DRUG: M701|DRUG: paracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Strategies for Titrating a High MAP on Microcirculation
Status: COMPLETED
Conditions: Septic Shock|Hypertension
Interventions: DRUG: Norepinephrine|DRUG: Crystalloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone as an Adjuvant to Ropivacaine for the Interscalene Brachial Plexus Block
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Placebo|DRUG: Dexamethasone 1 mg|DRUG: Dexamethasone 2 mg|DRUG: Dexamethasone 3 mg|DRUG: Dexamethasone 4 mg|DRUG: Ropivacaine 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Visnadin, Ethyl Ximeninate, Coleus Barbatus and Millet in Emulgel on Sexual Function in Postmenopausal Women
Status: RECRUITING
Conditions: Female Sexual Function|Vulvovaginal Atrophy|Postmenopausal Atrophic Vaginitis
Interventions: OTHER: Visnadin, ethyl ximeninate, coleus barbatus and millet in emulgel|OTHER: Emulgel-only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MAMA NO STRESS Project. The Effects of the "HAPPY MAMA" Intervention
Status: UNKNOWN
Conditions: Depression, Postpartum|Stress, Psychological|Postpartum Sadness|Self Efficacy|Mother-Infant Relations
Interventions: BEHAVIORAL: Collective Intervention "G"|BEHAVIORAL: Individual Intervention "I"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Stenosis|Heart Valve Diseases|Heart Diseases|Cardiovascular Diseases|Ventricular Outflow Obstruction
Interventions: DEVICE: JenaValve Pericardial TAVR System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-ethnic Multi-level Strategies and Behavioral Economics to Eliminate Hypertension Disparities in Los Angeles County
Status: NOT_YET_RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: Patient-focused strategies|BEHAVIORAL: Provider-focused strategies|BEHAVIORAL: Patient- and provider-focused strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Intradialytic Blood Pressure Slopes to Guide Ultrafiltration
Status: TERMINATED
Conditions: ESRD|Extracellular Fluid Alteration|Hypertension
Interventions: OTHER: Intradialytic Blood Pressure Slope Based Ultrafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IPV-102 Safety, Tolerability and Immunogenicity of TAK-195 in Healthy Infants, Toddlers and Adults
Status: TERMINATED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Sabin-Based Inactivated Poliomyelitis Vaccine (sIPV)|BIOLOGICAL: Reference IPV|BIOLOGICAL: sIPV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Maraviroc and/or Favipiravir With Standard Therapy in Severe COVID-19 Adults
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Maraviroc + Currently used therapy|PROCEDURE: Curently used therapy for COVID-19 non-critical patients|DRUG: Favipiravir + Currently used therapy|DRUG: Maraviroc+Favipiravir+CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT