pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Post-op Ketamine Study
Status: UNKNOWN
Conditions: Osteo Arthritis Knee
Interventions: DRUG: Isotonic saline|DRUG: Ketamine Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate (Gleevec) and Paclitaxel in Recurrent Patients of Ovarian and Other Cancers of Mullerian Origin
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: Gleevec/Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination High Dose Melphalan and Autologous Peripheral Blood Stem Cell (PBSC) Transplant With Bortezomib for Multiple Myeloma: A Dose and Schedule Finding Study
Status: TERMINATED
Conditions: Cancer|Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Melphalan|PROCEDURE: Autologous PBSC Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrazoloacridine and Stem Cell or Bone Marrow Transplantation in Treating Young Patients With High-Risk Neuroblastoma
Status: TERMINATED
Conditions: Disseminated Neuroblastoma|Recurrent Neuroblastoma
Interventions: DRUG: pyrazoloacridine|BIOLOGICAL: filgrastim|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Cohort Study of Incretin-based Therapy Combined With Insulin in Type 2 Diabetic Patients for 5 Years
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Incretin-based therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creating Resilient Workplaces Study
Status: COMPLETED
Conditions: PTSD|Anxiety Disorders|Depression|Stress Disorders, Posttraumatic
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy with Mindfulness Course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cardiometry Versus Fluid and Catheter Treatment Trial (FACTT Lite) on Fluid Management in Acute Respiratory Distress Syndrome Patients
Status: COMPLETED
Conditions: ARDS|Fluid Management|Cardiometry
Interventions: DEVICE: Electrical cardiometry|DRUG: Fluid and Catheter Treatment Trial "FACTT Lite"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b Study of Tizanidine in Pediatric Patients With Cerebral Palsy
Status: TERMINATED
Conditions: Spasticity Due to Cerebral Palsy
Interventions: DRUG: Zanaflex Capsules|DRUG: Zanaflex Capsules|DRUG: Zanaflex Capsules|DRUG: Zanaflex Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avycaz (Ceftazidime/Avibactam) Pharmacokinetics/Pharmacodynamics (PK/PD) in Critically Ill Patients
Status: COMPLETED
Conditions: Pharmacokinetics of Avycaz in ICU Patients
Interventions: DRUG: Ceftazidime/avibactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
Status: COMPLETED
Conditions: Stroke|Carotid Stenosis
Interventions: PROCEDURE: CEA|RADIATION: 18F PET-MRI|DIAGNOSTIC_TEST: Transcranial Doppler
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess Efficacy and Safety of Treamid for Patients With Reduced Exercise Tolerance After COVID-19
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection|Lung Fibrosis
Interventions: DRUG: Treamid|DRUG: Treamid twice a day|DRUG: Treamid once a day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thyroid Associated Orbitopathy Treatment by Methotrexate Against Triamcinolone Periocular Injections
Status: COMPLETED
Conditions: Thyroid Associated Orbitopathy
Interventions: DRUG: Methotrexate|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plantar Fasciitis Randomized Clinical Control Trial
Status: RECRUITING
Conditions: Plantar Fascitis
Interventions: PROCEDURE: Local Steroid Injection into the plantar heel|PROCEDURE: Ultrasound Guided Injection|PROCEDURE: Anatomical Guided injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine
Status: RECRUITING
Conditions: Migraine Without Aura|Headache
Interventions: DRUG: Levcromakalim|DRUG: Sumatriptan|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of ETC-1907206 With Dasatinib in Advanced Haematologic Malignancies
Status: WITHDRAWN
Conditions: Ph+ Acute Lymphoblastic Leukemia (Ph+ALL)|Ph- Acute Lymphoblastic Leukemia (Ph-ALL)|Chronic Myeloid Leukemia Accelerated Phase (CML-AP, Ph+)|Chronic Myeloid Leukemia Blast Crisis (CML-BC, Ph+)
Interventions: DRUG: ETC-1907206|DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of PF-06649751 in Parkinson's Disease Patients at Early Stage of the Disease
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DRUG: Placebo|DRUG: PF-06649751
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of ANK-101 in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Cutaneous Tumor|Subcutaneous Tumor|Malignant Solid Tumor|Solid Tumor|Metastatic Solid Tumor|Metastasis to Soft Tissue|Non Small Cell Lung Cancer
Interventions: DRUG: ANK-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 3)
Status: TERMINATED
Conditions: Depression|Anxiety Disorders|Stress Related Disorder|Adjustment Disorders|Chronic Illness
Interventions: BEHAVIORAL: Mindfulness Training for Primary Care|BEHAVIORAL: Low-Dose Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moxetumomab Pasudotox (CAT-8015, HA22) in Children With B-lineage Acute Lymphoblastic Leukemia and Minimal Residual Disease Prior to Allogeneic Hematopoietic Stem Cell Transplantation
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia (ALL)
Interventions: BIOLOGICAL: Moxetumomab Pasudotox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Strength-Based Intervention to Improve Job Interview Skills in Neurodiverse Young Adults
Status: NOT_YET_RECRUITING
Conditions: ADHD|Dyslexia|Learning Disabilities
Interventions: BEHAVIORAL: KF-STRIDE®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparative Study to Evaluate the Efficacy and Safety of Recombinant Anti-TNF-alpha Antibodies for Injection
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: GB242|BIOLOGICAL: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatments for Depression: Drug Versus Psychotherapy
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Supportive Expressive Therapy|DRUG: Sertraline|DRUG: Pill Placebo|DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)
Status: SUSPENDED
Conditions: Acute Myeloid Leukemia|Acute Lymphoid Leukemia|Mixed Phenotype Acute Leukemia|Acute Undifferentiated Leukemia|Chronic Myeloid Leukemia in Myeloid Blast Crisis|Chronic Myeloid Leukemia in Lymphoid Blast Crisis (Diagnosis)|Chronic Myeloid Leukemia - Accelerated Phase
Interventions: BIOLOGICAL: Orca-Q
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell/AML Fusion Cell Vaccine Following Allogeneic Transplantation in AML Patients
Status: RECRUITING
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: decitabine|BIOLOGICAL: DC/AML fusion cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients With Heart Failure With Preserved Ejection Fraction Adherence to ASV Therapy (PEP ASV)
Status: TERMINATED
Conditions: Sleep Disorder; Breathing-Related|Heart Failure
Interventions: BEHAVIORAL: Active Patient Engagement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Post Marketing Surveillance Study Assessing the Long-term Efficacy and Safety of Aptivus Co-administered With Low-dose Ritonavir in Treatment Experienced Patients With HIV-1 Infection in the Daily Clinical Practice.
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tipranavir|DRUG: ritonavir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chia Seeds Consumption in Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: OTHER: Control|DIETARY_SUPPLEMENT: Omega-3 supplementation|OTHER: Chia seed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers
Status: TERMINATED
Conditions: Cardiovascular Diseases
Interventions: OTHER: Eligibility and lifestyle restrictions check.|OTHER: Medical history, demographic and lifestyle factors|OTHER: Anthropometric measurements: height, weight, and body fat|OTHER: Blood pressure and heart rate|OTHER: Forearm blood flow: Visit 1 (EDNRA)|OTHER: Forearm blood flow: Visit 2 (EDNRA)|OTHER: Blood biochemistry (PNPLA3)|OTHER: Blood EPCR function (PROCR)|OTHER: Blood platelet coagulation and function (PROCR)|OTHER: Blood endothelial permeability (PROCR)|OTHER: Blood leukocyte-endothelium adhesion (PROCR)|OTHER: Baseline Venepuncture (PNPLA3, Visit 1)|OTHER: Deuterium water - Loading dose 1 (PNPLA3, Visit 1)|OTHER: Deuterium water - Loading dose 2 (PNPLA3, Visit 1)|OTHER: Energy-balanced dinner (PNPLA3, Visit 1)|OTHER: Fasting venepuncture (PNPLA3, Visit 2)|OTHER: Deuterium water - Maintenance dose (PNPLA3, Visit 2)|OTHER: Consumption of high carbohydrate meal (PNPLA3, Visit 2)|OTHER: Postprandial Venepuncture (PNPLA3, Visit 2)|OTHER: Venepuncture (PROCR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Access to Community-Based Occupations Via a Rideshare Training Program
Status: RECRUITING
Conditions: Autism
Interventions: BEHAVIORAL: Intervention Phase|BEHAVIORAL: Virtual Training Sessions|BEHAVIORAL: Ride-Along Training Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Safety of Nutritears® in Adults With Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye|Dry Eye Syndromes
Interventions: DIETARY_SUPPLEMENT: Nutritears®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Study Confirmed Inhibition of Autophagy Synergizes Anti-tumor Effect of High Dose CDK4/6i
Status: RECRUITING
Conditions: Inhibition of Autophagy Synergizes Anti-tumor Effect
Interventions: DRUG: 600mg bid dose of hydroxychloroquine combined with three predefined dose groups of palbociclib|DRUG: RP2D dose of 600mg bid of hydroxychloroquine combined with palbociclib was selected for phase II clinical trial.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension
Status: COMPLETED
Conditions: Congenital Heart Disease|Pulmonary Arterial Hypertension
Interventions: DRUG: Sildenafil singly or in association with Bosentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Aumonertinib 165mg orally once daily and intrathecal chemotherapy with pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ritonavir-Boosted GS-9137 vs. Ritonavir-Boosted Protease Inhibitor(s) in Combination With Background ART.
Status: COMPLETED
Conditions: HIV|HIV-1|Human Immunodeficiency Virus
Interventions: DRUG: GS-9137 - A Novel HIV-1 Integrase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of Lenalidomide in Relapsed or Refractory B-cell Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Leukemia, B-Cell, Chronic
Interventions: DRUG: lenalidomide|DRUG: lenalidomide|DRUG: lenalidomide|DRUG: lenalidomide|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impacts of Intermittent Chest Tube Clamping on Chest Tube Drainage Duration and Postoperative Hospital Stay After Lung Cancer Surgery
Status: COMPLETED
Conditions: Management of Lung Cancer Patients
Interventions: PROCEDURE: clamping group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Single-Agent Eribulin Mesylate as First-Line Therapy for Locally Recurrent or Metastatic Human Epidermal Growth Factor Receptor Two (HER2) Negative Breast Cancer
Status: COMPLETED
Conditions: Locally Recurrent|Metastatic Breast Cancer ( HER2 Negative)
Interventions: DRUG: Eribulin mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)
Status: COMPLETED
Conditions: Gastric Ulcers|Duodenal Ulcers
Interventions: DRUG: TAK-438|DRUG: Placebo|DRUG: TAK-438|DRUG: Placebo|DRUG: Lansoprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RFA Combined With Oxaliplatin + 5-FluoroUracil/LeucoVorin (5-FU/LV) (FOLFOX4) for Recurrent HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: RFA|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil/Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Dor Versus Toupet Fundoplication for the Treatment of Idiopathic Esophageal Achalasia
Status: COMPLETED
Conditions: Esophageal Achalasia
Interventions: PROCEDURE: Dor fundoplication|PROCEDURE: Toupet fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine
Status: COMPLETED
Conditions: Tobacco Toxicant Exposure
Interventions: DRUG: Deuterated phenanthrene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Holmium Laser vs Bipolar Enucleation of a Large Volume BPH: a Randomised Controlled Study
Status: COMPLETED
Conditions: BPH With Urinary Obstruction|Male
Interventions: PROCEDURE: Holmium laser enucleation of the prostate|PROCEDURE: Bipolar plasma kinetic enucleation of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Crossover, Multi-Dose Pharmacokinetics of EXCL-100 Pirfenidone-Sustained Release Tablet and Esbriet in Healthy Volunteers
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Esbriet 267 MG Oral Capsule|DRUG: EXCL-100, 600 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)
Status: COMPLETED
Conditions: Acute Rhinosinusitis
Interventions: DRUG: mometasone furoate nasal spray (MFNS)|DRUG: MFNS|DRUG: Amoxicillin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Plus Cisplatin Compared With Etoposide Plus Cisplatin for Extensive Stage Small-cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Irinotecan|DRUG: Etoposide|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COLLISION Trial - Colorectal Liver Metastases: Surgery vs Thermal Ablation
Status: RECRUITING
Conditions: ColoRectal Cancer|Liver Metastasis Colon Cancer|Liver Metastases|Surgery
Interventions: PROCEDURE: Thermal ablation|PROCEDURE: Surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Soft Fruit on Postprandial Blood Glucose
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Blackcurrants with polycal OGTT|DIETARY_SUPPLEMENT: Greencurrants with polycal OGTT|DIETARY_SUPPLEMENT: Blackcurrants with glucose OGTT|DIETARY_SUPPLEMENT: Sugar matched water with polycal OGTT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Plant Stanol Esters and Influenza Vaccination
Status: COMPLETED
Conditions: Immune Response
Interventions: BIOLOGICAL: Influenza vaccine|DIETARY_SUPPLEMENT: Plant stanol soft chews (2g per day)|DIETARY_SUPPLEMENT: Plant stanol soft chews (3g per day)|DIETARY_SUPPLEMENT: Plant stanol soft chews (4g per day)|DIETARY_SUPPLEMENT: Control soft chews
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Isolated Limb Infusion of Chemotherapy in Treating Patients With Melanoma or Soft Tissue Sarcoma of the Arm or Leg That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Melanoma (Skin)|Sarcoma
Interventions: BIOLOGICAL: dactinomycin|DRUG: isolated limb perfusion|DRUG: melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Coffee on Hepatic Steatosis Induced by a High Fructose Diet
Status: COMPLETED
Conditions: Hepatic Steatosis
Interventions: DIETARY_SUPPLEMENT: Ctl|DIETARY_SUPPLEMENT: High fructose diet; no coffee|DIETARY_SUPPLEMENT: fully torrefied, caffeine-free coffee|DIETARY_SUPPLEMENT: partially torrefied, caffeine-free coffee|DIETARY_SUPPLEMENT: Partially torrefied, caffeinated coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Extension Biased External Limb Loading in Addition to McKenzie Extension Protocol in Lumbar Derangement Syndrome
Status: COMPLETED
Conditions: Sciatica|Low Back Pain|Low Back Pain, Mechanical
Interventions: OTHER: Extension Biased External Limb Loading Exercises|OTHER: McKenzie Extension Exercise Protocol|OTHER: Moist Heat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of LuoXin Innovate (LXI-15028) in Healthy Chinese Subjects to Evaluate the Pharmacokinetics, Safety and Tolerability.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LXI-15028 50mg|DRUG: LXI-15028 100mg|DRUG: LXI-15028 200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic Myelomonocytic Leukemia (CMML)
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia|Chronic Myelomonocytic Leukemia
Interventions: DRUG: DTGM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Tumoral Biomarker B3 Adrenergic Receptor in Paediatric Solid Tumours
Status: RECRUITING
Conditions: Tumor
Interventions: OTHER: Analysis of peripheral blood (control group)|OTHER: Analysis of biological sample (Substudy-solid neoplasms)|OTHER: Analysis of biological sample (substudy-leukaemia patients)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Noninvasive Continuous Positive Airway Pressure (NCPAP) in Children
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: DEVICE: NCPAP by helmet|DEVICE: NCPAP by facial mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Thymosin Alpha 1 Plus Maintenance Therapy With the Standard of Care (SoC) in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC), EGFR Wild Type
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Thymalfasin (Thymosin alpha 1, Ta1)|DRUG: SoC (chemotherapy and platinum agent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cleaning Agents Impact on Invisalign Aligners: A Cross-Over Randomized Trial
Status: COMPLETED
Conditions: Aligner Staining
Interventions: OTHER: non-abrasive toothpaste|OTHER: abrasive toothpaste|OTHER: Efferdent|OTHER: Cleaning Crystals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Safety, Efficacy of Tegoprazan for the Prevention of PUD in Patients on Treatment With NSAIDs
Status: RECRUITING
Conditions: Preventive Peptic Ulcer
Interventions: DRUG: Lansoprazole 15 mg|DRUG: Tegoprazan 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Filgrastim, Cladribine, Cytarabine, and Mitoxantrone With Sorafenib in Treating Patients With Newly-Diagnosed, Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Biphenotypic Leukemia|Acute Myeloid Leukemia|de Novo Myelodysplastic Syndrome|Myelodysplastic Syndrome|Myeloproliferative Neoplasm
Interventions: DRUG: Cladribine|DRUG: Cytarabine|BIOLOGICAL: Filgrastim|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|DRUG: Mitoxantrone|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Serum interleukin10 Level in Patients With Immune Thrombocytopenic Purpura at Sohag University Hospital
Status: NOT_YET_RECRUITING
Conditions: Immune Thrombocytopenic Purpura
Interventions: DIAGNOSTIC_TEST: serum interleukin 10 level
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Assess the Bioequivalence of Ibrutinib 560- Milligram (mg) Tablet to Four 140 -mg IMBRUVICA Capsules
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IMBRUVICA (Treatment A)|DRUG: Ibrutinib (Treatment B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing Effects of Two Fixed Combinations Ophthalmic Solutions on Ocular Blood Flow
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: fixed combination of brimonidine tartrate 0.2% timolol maleate 0.5% ophthalmic solution|DRUG: fixed combination of dorzolamide hydrochloride timolol maleate ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Patient-Centered Home Care (PCHC) to Reduce Disparities in High-Risk Black Men (BM) With Advanced Prostate Cancer (CaP)
Status: RECRUITING
Conditions: Advanced Prostate Adenocarcinoma|Metastatic Prostate Adenocarcinoma|Stage III Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparation of Chidamide Plus VRD (Bortezomib, Lenalidomide, Dexamethasone) With VRD Regimen for Primary High-Risk Multiple Myeloma Patients
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Chidamide+VRD|DRUG: VRD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sativex and Behavioral-relapse Prevention Strategy in Cannabis Dependence
Status: COMPLETED
Conditions: Cannabis Dependence
Interventions: BEHAVIORAL: Motivational Enhancement/Cognitive Behavioral Therapy|DRUG: Sativex|DRUG: Placebo spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study of the Safety, Tolerability,PK & PD of EPZ-5676 in Treatment Relapsed/Refractory Patients With Leukemias Involving
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome|Myeloproliferative Disorders
Interventions: DRUG: EPZ-5676
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of PK, PD, Safety of Multiple Intravenous Injections of BCD-066 and Aranesp in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: BCD-066|BIOLOGICAL: Aranesp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: The ALA, DHA and EPA Esters in the Prevention of Cardiovascular Diseases.
Status: UNKNOWN
Conditions: Fatty Acids|Alpha-Linolenic Acid|Docosahexaenoic Acids|Eicosapentaenoic Acid|Preventive Health Services|Preventive Medicine|Cardiovascular Diseases|Anti-Inflammatory Agents
Interventions: DRUG: Fatty Acids, Unsaturated|DIAGNOSTIC_TEST: Diagnostic Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Closed-Loop With Faster Aspart in Young Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Fast-CL|DRUG: Regular-CL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tramadol and Dexmedetomidine in the Prevention of Urinary Catheter Discomfort in Urinary Surgery
Status: COMPLETED
Conditions: Catheter Related Complication
Interventions: DRUG: Tramadol|DRUG: Dexmedetomidine|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cladribine Based Induction Therapy With All-Trans Retinoic Acid and Midostaurin in Relapsed/Refractory AML
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Granulocyte colony-stimulating factor (G-CSF)|DRUG: Cladribine|DRUG: Cytarabine|DRUG: All-Trans Retinoic Acid (ATRA)|DRUG: Midostaurin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tenofovir Alafenamide (TAF) in Children and Teen Participants With Chronic Hepatitis B Virus Infection
Status: RECRUITING
Conditions: Chronic Hepatitis B
Interventions: DRUG: TAF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Varying Portion Size and Palatability on Food Intake of Preschool Children
Status: TERMINATED
Conditions: Feeding Behavior
Interventions: OTHER: Smaller Portion Size and Standard Appeal (non-divided plate)|OTHER: Smaller Portion Size and Enhanced Appeal (divided plate)|OTHER: Larger Portion Size and Standard Appeal (non-divided plate)|OTHER: Larger Portion Size and Enhanced Appeal (divided plate)|OTHER: Smaller Portion Size and Standard Appeal (divided plate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Oleclumab|DRUG: Monalizumab|DRUG: Dato-DXd|DRUG: AZD0171|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed/Cisplatin|DRUG: Pemetrexed/Carboplatin|DRUG: Carboplatin/Paclitaxel|DRUG: Volrustomig
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Effects of Vitamin D Supplementation on the Chronic Course of Patients With Crohn's Disease With Vitamin D Deficiency
Status: UNKNOWN
Conditions: Crohn's Disease|Vitamin D Deficiency|Vitamin D Supplement
Interventions: DRUG: Vitamin D drops
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-of-1 in ATS and MEPPC
Status: NOT_YET_RECRUITING
Conditions: Andersen Tawil Syndrome|Multifocal Ectopic Purkinje-related Premature Contractions
Interventions: DRUG: Flecainide|DRUG: Flecainide + beta-blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Between Capozide Versus ACE-Hemmer-ratiopharm in Healthy Adult Participants Under Fasting Conditions
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: Capozide|DRUG: ACE-Hemmer-Ratiopharm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of APX005M With Gemcitabine and Nab-Paclitaxel With or Without Nivolumab in Patients With Previously Untreated Metastatic Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: APX005M|DRUG: Nivolumab|DRUG: Nab-Paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Revaccination With PNEUMOVAX(TM) 23 in Older Adults (V110-007)
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: pneumococcal 23v polysaccharide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of CTP-543 in Adults With Moderate to Severe Alopecia Areata (THRIVE-AA2)
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: CTP-543 matching placebo|DRUG: CTP-543
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab Combined With Apatinib and Oxaliplatin Plus S1 Vs Oxaliplatin Plus S1 as Neoadjuvant Therapy for Borrmann IV、Large Borrmann III Type and Bulky N Positive Advanced Gastric Cancer
Status: RECRUITING
Conditions: Immunotherapy Gastrict Cancer
Interventions: DRUG: Tislelizumab|DRUG: apatinib|DRUG: oxaliplatin|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of SYN023 to Human Rabies Immune Globulin in Post Exposure Prophylaxis of Rabies
Status: COMPLETED
Conditions: Rabies
Interventions: BIOLOGICAL: SYN023|BIOLOGICAL: HRIG (HyperRab)|BIOLOGICAL: Rabies vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Short Stature
Interventions: DRUG: Vosoritide Injection|DRUG: Human Growth Hormone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Sleep Wearables to Adapt Cognitive-behavioral Therapy for Insomnia in the Context of Depression (CBTiA)
Status: NOT_YET_RECRUITING
Conditions: Insomnia|Major Depressive Disorder|Persistent Depressive Disorder
Interventions: COMBINATION_PRODUCT: eCBTi-obj|BEHAVIORAL: eCBTi-subj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-incubation Levulan Photodynamic Therapy Versus Vehicle for Face/Scalp Actinic Keratosis (AK)
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Broad Area ALA 1-hour incubation|DRUG: Broad Area ALA 2 hour incubation|DRUG: broad area ALA 3-hour incubation|DRUG: Spot ALA 2 hour incubation|DRUG: Vehicle PDT|DEVICE: Blue Light Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Preoperative Counseling and Education in Reducing Anxiety Levels in Patients With Gynecologic Tumors
Status: UNKNOWN
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Pre-operative Counseling and Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Preventive Treatment of Migraine With Low-Dose Naltrexone and Acetaminophen Combination
Status: COMPLETED
Conditions: Migraine With or Without Aura
Interventions: DRUG: Low-Dose Naltrexone and Acetaminophen Combination|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Mesh-RTL Project, for Prevention of Incisional Hernia
Status: COMPLETED
Conditions: Hernia Incisional
Interventions: PROCEDURE: Mesh reinforcement|PROCEDURE: RTL reinforcement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease
Status: TERMINATED
Conditions: Sickle Cell Disease|Sickle Cell Anemia
Interventions: DRUG: vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety of and Adherence to a Vaginal Matrix Ring Containing Dapivirine and Oral Emtricitabine/Tenofovir Disoproxil Fumarate in an Adolescent and Young Adult Female Population
Status: COMPLETED
Conditions: HIV Infections
Interventions: DEVICE: Dapivirine vaginal ring|DRUG: FTC/TDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multicenter Open Label Phase 2 Study of Isatuximab Plus Pomalidomide and Dexamethasone With Carfilzomib in Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory
Interventions: DRUG: Isatuximab|DRUG: Carfilzomib|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal Pockets
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DEVICE: 810 Nanometer Wavelenght GaAlAs Diode Laser|DEVICE: Gracey curettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Ovarian Sarcoma|Ovarian Stromal Cancer|Recurrent Endometrial Carcinoma|Recurrent Ovarian Epithelial Cancer|Recurrent Ovarian Germ Cell Tumor|Stage III Endometrial Carcinoma|Stage III Ovarian Epithelial Cancer|Stage III Ovarian Germ Cell Tumor|Stage IV Endometrial Carcinoma|Stage IV Ovarian Epithelial Cancer|Stage IV Ovarian Germ Cell Tumor|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: paclitaxel|DRUG: carboplatin|DRUG: temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an Anti-inflammatory Diet on Patients With Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer|Uterine Cervical Neoplasm|Pelvic Inflammatory Disease|Radiation Toxicity|Diet Modification
Interventions: OTHER: Omega-3 fatty acids|OTHER: Antioxidants|OTHER: Soluble fiber|OTHER: Probiotics|OTHER: Lactose restriction|OTHER: Fiber restriction|OTHER: Fat restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Digital Variance Angiography for Contrast Media Dose Reduction in Carotid Artery Stenting
Status: UNKNOWN
Conditions: Carotid Artery Diseases
Interventions: PROCEDURE: Carotid artery stenting with standard contrast media protocol|PROCEDURE: Carotid artery stenting with reduced contrast media protocol|DIAGNOSTIC_TEST: Carotid Duplex Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of a Food Supplement in the Prevention of Urinary Tract Infections in Kidney Transplant Patients.
Status: COMPLETED
Conditions: Kidney Transplant Infection
Interventions: DIETARY_SUPPLEMENT: MANOSAR®|DIETARY_SUPPLEMENT: Proanthocyanidins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Short-term Efficacy of Intravitreal Afilibercept Depending on Subtypes of Polypoidal Choroidal Vasculopathy: Polypoidal Choroidal Neovascularization or Idiopathic Choroidal Vasculopathy
Status: UNKNOWN
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: Aflibercept|DRUG: Indocyanine green angiography (intraveonus indocyanine green dye)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Intramural Fibroids on IVF Outcome
Status: UNKNOWN
Conditions: Infertility, Female|Assisted Reproduction
Interventions: DRUG: Gonadotropins|DRUG: human chorionic gonadotropin|PROCEDURE: Ovum pick up|PROCEDURE: Embryo transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Integrating Services for Noncommunicable Diseases in Continuum of Care for Mothers and Children
Status: COMPLETED
Conditions: Continuum of Care|Noncommunicable Diseases
Interventions: BEHAVIORAL: Integrating services for noncommunicable diseases in continuum of care for mothers and children|BEHAVIORAL: Ordinary health education for pregnant women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Role of Computerized Training in Post-Traumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Bias Modification of Appraisals (CBM-App)|BEHAVIORAL: Peripheral Vision Task (control condition)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk of Hypoglycemia in the Transition From Inpatient to Outpatient Setting. Comparative Study of Basal-bolus Insulin Versus Basal Insulin Plus GLP-1 Analogue
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2 Treated With Insulin
Interventions: DRUG: insulin degludec + liraglutide|DRUG: Insulin Glargine - Insulin Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Chicken Extract and a Peptide Supplement for the Prevention of Cognitive Decline in Non-demented Elderly Adults
Status: COMPLETED
Conditions: Cognitive Decline|Mild Cognitive Impairment|Aging
Interventions: DIETARY_SUPPLEMENT: Chicken extract supplement|DIETARY_SUPPLEMENT: Peptide Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Denufosol Tetrasodium Intravitreal Injection in Subjects With Post Cataract Extraction Macular Edema
Status: WITHDRAWN
Conditions: Macular Edema, Cystoid
Interventions: DRUG: denufosol tetrasodium (INS37217) Intravitreal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Immunogenicity of a Seasonal Influenza VLP Vaccine (Recombinant) in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza VLP Vaccine (recombinant)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility and Safety Study Comparing REG1 Anticoagulation System With Unfractionated Heparin in Elective PCI
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: REG1|DRUG: REG1|DRUG: Unfractionated Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontal Parameters in Orthodontic Patients With Stainless Steel and Ceramic Brackets.
Status: ENROLLING_BY_INVITATION
Conditions: Periodontal Inflammation|Dental Malocclusion
Interventions: OTHER: Fixed orthodontic treatment with stainless steel brackets|OTHER: Fixed orthodontic treatment with ceramic brackets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Olaptesed pegol|RADIATION: Radiotherapy|DRUG: Bevacizumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alprostadil as an Adjuvant Therapy With Indirect Angiosomal Revascularization in Critical Limb Ischemia.
Status: UNKNOWN
Conditions: Critical Limb Ischemia
Interventions: DRUG: Alprostadil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT