pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients
Status: COMPLETED
Conditions: Hypoparathyroidism
Interventions: DIETARY_SUPPLEMENT: amorphous calcium carbonate|DIETARY_SUPPLEMENT: crystalline calcium supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of BD Onclarity™ HPV Assay With PreservCyt® -ASCUS Samples
Status: TERMINATED
Conditions: Uterine Cervical Neoplasm
Interventions: PROCEDURE: Colposcopy/biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Second Line Erlotinib (Tarceva) Plus Digoxin in Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: Erlotinib plus Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Occlusal Accommodation of the Mouthguard on the Degree of Satisfaction of Water Polo Players
Status: COMPLETED
Conditions: Satisfaction|Quality of Life
Interventions: DEVICE: Conventional Mouthguard|DEVICE: Occlusal-adjusted Mouthguard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Performance Evaluation of SARS-COV-2 (Covid-19) Antigen Rapid Test
Status: WITHDRAWN
Conditions: SARS-CoV-2|Covid-19|Coronavirus
Interventions: DIAGNOSTIC_TEST: Xiamen Wiz Biotech Co., Ltd. SARS-CoV-2 Antigen Rapid Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 2-Methoxyestradiol in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Stage III Multiple Myeloma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: 2-methoxyestradiol|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Hydrochloride Before Surgery in Treating Patients With Kidney Cancer
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Stage I Renal Cell Cancer|Stage II Renal Cell Cancer|Stage III Renal Cell Cancer
Interventions: DRUG: pazopanib hydrochloride|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Best Practice Alerts in Cardiology Outpatient Clinics
Status: COMPLETED
Conditions: Hypertension|Atrial Fibrillation
Interventions: OTHER: Best Practice Alert based in the Electronic Medical Record
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessing Current Peripheral Nerve Block Catheter Fixation and Dressing Strategies: An Equivalence Study
Status: WITHDRAWN
Conditions: Regional Anesthesia Morbidity
Interventions: DEVICE: 2-octyl cyanoacrylate|DEVICE: Gum Mastic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: New Combination Inhaler (FlutiForm HFA MDI 100/10 µg and 250/10 µg) in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone propionate/formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular EffectS of regUlar Cigarettes Versus electronIc Cigarette USe
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: DEVICE: electronic cigarette + 16mg nicotine & flavor|OTHER: electronic cigarette + 0mg nicotine & flavor|OTHER: Tobacco cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effect of a Five Week Electrical Myostimulation Program in Chronic Diseases
Status: UNKNOWN
Conditions: Heart Failure
Interventions: PROCEDURE: Medium-frequency alternating current|PROCEDURE: Burst-modulated alternating current|PROCEDURE: Placebo|PROCEDURE: Functional electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Combined Fulvestrant and Everolimus in Advanced/Metastatic Breast Cancer After Aromatase Inhibitor Failure
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Everolimus|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Hygiene Compliance in Orthodontic Patients Using Active Reminders
Status: RECRUITING
Conditions: Oral Hygiene|Dental Plaque
Interventions: OTHER: WhatsApp reminders|OTHER: Instagram reminders|OTHER: Phone calls|OTHER: Application alerts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Solifenacin, Levofloxacin or Lornoxicam, Which Is Ideal for Management of Intravesical Instillation BCG Side Effects?
Status: UNKNOWN
Conditions: Non-Muscle-invasive Bladder Cancer (NMIBC)|Bacillus Calmette-Guerin (BCG) Cystitis|Intra-vesical Instillation
Interventions: DRUG: sofenacin|DRUG: Tavanic|DRUG: Xefo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Increasing Testosterone on Insulin Sensitivity in Men With the Metabolic Syndrome
Status: TERMINATED
Conditions: Metabolic Syndrome
Interventions: DRUG: Zoladex|DRUG: Testosterone gel|DRUG: Anastrozole Pill|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Memantine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy
Status: RECRUITING
Conditions: Multiple System Atrophy
Interventions: BIOLOGICAL: Autologous Mesenchymal Stem Cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Tislelizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Urothelial Bladder Cancer
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advancing Health Information Exchange (HIE) During Inter-hospital Transfer (IHT) to Improve Patient Outcomes
Status: ENROLLING_BY_INVITATION
Conditions: Infections|Heart Failure|COPD Exacerbation|Asthma|Gastrointestinal Diseases|Cardiac Event|Arrythmia|Renal Failure|Renal Disease|Rheumatic Diseases|Urologic Diseases|Neurologic Disorder|Hematologic Diseases|Oncology Problem|Shock|Critical Illness
Interventions: OTHER: Health Information Exchange (HIE) platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Enrollment in and Utilization of the Flex Nutrition Program
Status: NOT_YET_RECRUITING
Conditions: Food Insecurity|Vulnerable Populations|Nutrition, Healthy
Interventions: OTHER: High Intensity Proactive Outreach|OTHER: Low Intensity Proactive Outreach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome
Status: RECRUITING
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Vaginal estrogen|DRUG: Mirabegron 50 MG [Myrbetriq]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Etanercept 50 mg Once Weekly Plus As Needed Topical Agent in Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: etanercept|DRUG: Topical agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Radiotherapy With Cisplatin Alone or in Combination With Iressa in Upper Aerodigestive Tract Carcinomas
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: Iressa (Gefitinib)|RADIATION: chemoradiotherapy with cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension Study of [S,S]-Reboxetine in Patients With Fibromyalgia
Status: TERMINATED
Conditions: Fibromyalgia
Interventions: DRUG: [S,S]-Reboxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of L04TD1 Compared to Administration of L04RD1 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: L04RD1|DRUG: L04TD1|DRUG: L04TD1|DRUG: L04RD1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Equivalence Study of Tuberculin Purified Protein Derivative in Comparison With a Reference Standard (PPD-S2)
Status: UNKNOWN
Conditions: Tuberculosis Identification.
Interventions: BIOLOGICAL: To compare new PPD to reference standard material|BIOLOGICAL: Reference standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Bioavailability Study of Risperidone Orally Disintegrating Tablets 1 mg of Dr.Reddy's Laboratories Limited Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Risperidone Orally Disintegrating Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFFECTS OF VESTIBULAR REHABILITATION THERAPY (VRT) ON BALANCE, SPEED AND AGILITY IN POST-CONCUSSION FOOTBALL PLAYERS
Status: COMPLETED
Conditions: Concussion, Mild
Interventions: OTHER: Cawthorne Cooksey Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Desmoplastic Small Round Cell Tumor|Rhabdomyosarcoma
Interventions: DRUG: Prexasertib|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose-Rate Brachytherapy and/or Intensity Modulated External Beam Radiation Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate
Interventions: PROCEDURE: high dose-rate brachytherapy|PROCEDURE: intensity-modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous CT-guided Cryoablation of the Splanchnic Nerves
Status: WITHDRAWN
Conditions: Type 2 Diabetes
Interventions: DEVICE: CT Guided Splanchnic Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Eprotirome for the Treatment of Dyslipidemia, Efficacy and Safety 12-Week, Phase ii Study to Assess the Safety and Efficacy of KB2115 in Patients With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: Eprotirome|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and Temozolomide
Status: TERMINATED
Conditions: Ewing Sarcoma|Ewing Family of Tumors|Ewing's Tumor Metastatic|Ewing's Sarcoma Metastatic|Ewing's Tumor Recurrent|Rare Diseases|Sarcoma|Neoplasms, Connective and Soft Tissue|Neoplasms by Histologic Type|Neoplasms, Bone Tissue|Neoplasms, Connective Tissue|Sarcoma, Ewing|Neoplasms
Interventions: BIOLOGICAL: Vigil|DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Subconscious Memory Extinction in Patients With Alcohol Dependence and Its Mechanism
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Very brief extinction|BEHAVIORAL: Clearly visible extinction|BEHAVIORAL: Very brief neutral extinction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of MEDI0382 in Japanese Preobese or Obese Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: MEDI0382 100 μg|DRUG: MEDI0382 200 μg|DRUG: MEDI0382 300 μg|DRUG: PlaceboA|DRUG: MEDI0382 50 ug|DRUG: PlaceboB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Promoting Physical Activity in Breast Cancer Survivors on Aromatase Inhibitors
Status: RECRUITING
Conditions: Breast Cancer Female|Hormone-receptor-positive Breast Cancer
Interventions: BEHAVIORAL: Brief Physical Activity Counselling|BEHAVIORAL: Structured Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Emapalumab and Anakinra in Reducing Hyperinflammation and Respiratory Distress in Patients With COVID-19 Infection.
Status: TERMINATED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: Emapalumab|BIOLOGICAL: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Daclizumab High Yield Process (DAC HYP) to Treat Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: BIOLOGICAL: BIIB019 (Daclizumab High Yield Process)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Lenvatinib Combined With VIC-1911 for the Treatment of Advanced HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Lenvatinib Combined with VIC-1911
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sarizotan in Participants With Parkinson's Disease Suffering From Treatment Associated Dyskinesia
Status: COMPLETED
Conditions: Parkinson's Disease|Dyskinesia
Interventions: DRUG: Sarizotan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of 3% Boric Acid in 70% Alcohol Versus 1% Clotrimazole Solution in Otomycosis Patients
Status: COMPLETED
Conditions: Otomycosis
Interventions: DRUG: clotrimazole|DRUG: 3% Boric acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thiotepa and Radiation Therapy in Treating Young Patients With Newly Diagnosed Malignant Brain Tumors
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: thiotepa|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Dose Escalation, Pharmacodynamic, Pharmacokinetic, and Effect of Food Phase 1 Study of E7820 to Determine the Maximum Tolerated Dose Following Twice Daily Oral Administration in Subjects With Unresectable Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: E7820|DRUG: E7820
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cellularity Yield of Three Different 22-gauge FNA Needles
Status: COMPLETED
Conditions: Pancreatic or Peripancreatic Lesions|Lesions in the Esophagus, Stomach, Duodenum or Rectum|Mediastinal ( Chest) Masses|Enlarged Lymph Nodes
Interventions: PROCEDURE: Endoscopic Ultrasound Fine Needle Aspiration (EUS-FNA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1b Trial to Evaluate Safety and Effect of SAR443122 on Immune System in Severe COVID-19
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: DRUG: SAR443122|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide-Adriamycin-Dexamethasone (RAD) Induction Followed by Stem Cell Transplant in Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: PROCEDURE: allogeneic stem cell transplant versus second autologous transplantation|DRUG: RAD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-controlled Study to Determine the Safety and Tolerability of Subcutaneous Doses of Sevuparin
Status: COMPLETED
Conditions: Safety and Tolerability
Interventions: DRUG: Sevuparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Osteoarthritis Pain
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DRUG: Buprenorphine|DRUG: Buprenorphine|DRUG: oxycodone immediate-release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Dialysis Dosage on Prognosis in Maintenance Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: End-stage Renal Disease
Interventions: DRUG: 6 L dialysate|DRUG: 8 L dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Wearable Devices to Assess the Impact of Stress in Workers' Life Quality
Status: COMPLETED
Conditions: Stress Disorder|Burnout, Professional|Sleep Disorder|Quality of Life|Anxiety State
Interventions: DEVICE: Xiaomi MiBand3|OTHER: Socio-demographic questionnaire|OTHER: EuroQol-5D-5L|OTHER: Pittsburgh Sleep Quality Index (PSQI)|OTHER: State-Trait Anxiety Inventory (STAI)|OTHER: Perceived Stress Scale-10 (PSS-10)|OTHER: Stress questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Norepinephrine as Early Vasopressor Therapy in Children Undergoing Mechanical Ventilation
Status: UNKNOWN
Conditions: Shock|Mechanical Ventilation
Interventions: DRUG: Norepinephrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tele-rehabilitation for Female Athletes With Pelvic Floor Dysfunctions
Status: COMPLETED
Conditions: Pelvic Floor Disorders
Interventions: BEHAVIORAL: Pelvic floor muscle training with biofeedback device|BEHAVIORAL: Pelvic floor muscle training|BEHAVIORAL: Information about pelvic floor and communication with health professionals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation in Supported Employment at Human Service Center (HSC)
Status: UNKNOWN
Conditions: Vocational Rehabilitation|Schizophrenia|Mental Disorders|Cognitive Symptoms
Interventions: DEVICE: Computerized cognitive training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis
Status: RECRUITING
Conditions: Primary Gonarthrosis
Interventions: DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
Status: RECRUITING
Conditions: Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Mobile App & Population Management System to Manage Rheumatoid Arthritis Flares
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthritis|Rheumatoid Arthritis
Interventions: OTHER: Mobile Application|OTHER: Population Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reducing Drug Use and HIV Risk in Drug-dependent Adults Arrested for Prostitution
Status: COMPLETED
Conditions: Substance-related Disorders|HIV Risk Behavior
Interventions: BEHAVIORAL: Therapeutic Workplace|DRUG: Methadone|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination of Gemcitabine, Oxaliplatin (GEMOX)-Sorafenib in Patients With Advanced Biliary Tract Cancer
Status: TERMINATED
Conditions: Cholangiocarcinoma|Biliary Tract Cancer|Gallbladder Cancer
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improved Cardiovascular Disease hEALth Service Delivery in Australia: Cluster Randomised Controlled Trial (IDEAL Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases
Interventions: DIAGNOSTIC_TEST: Cardiovascular disease risk assessment|DIAGNOSTIC_TEST: Usual care assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cryotherapy on the Outcome of Pulpotomy and Root Canal Treatment
Status: RECRUITING
Conditions: Pulpitis|Caries; Dentin|Pain, Postoperative
Interventions: PROCEDURE: Vital pulp cryotherapy|PROCEDURE: Intracanal cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Empiric Therapy of Helminth Co-infection to Reduce HIV-1 Disease Progression
Status: COMPLETED
Conditions: HIV Infections|Helminthiasis
Interventions: DRUG: Albendazole|DRUG: Praziquantel|DRUG: Current standard of care in Kenya
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Cisplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: cisplatin|DRUG: gemcitabine hydrochloride|PROCEDURE: biopsy|PROCEDURE: cystoscopy|PROCEDURE: therapeutic conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating the Efficacy and Safety of RPh201 Treatment in Individuals With Alzheimer's Disease With or Without Coexisting Cerebrovascular Disease
Status: COMPLETED
Conditions: Mild to Moderate Dementia Due to Alzheimer's Disease|With or Without Coexisting Cerebrovascular Disease
Interventions: DRUG: RPh201|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Interventions to Reduce Disability From Visual Loss in Nursing Home Residents
Status: COMPLETED
Conditions: Cataract|Refractive Error|Low Vision
Interventions: PROCEDURE: Visual impairment intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Patients With HBeAg Positive Chronic Hepatitis B.
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Ginger Supplement on Digestive Complaints in Healthy Adults Versus a Placebo
Status: NOT_YET_RECRUITING
Conditions: Dyspepsia
Interventions: DIETARY_SUPPLEMENT: Ginger formula|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of PONV With Traditional Chinese Medicine
Status: UNKNOWN
Conditions: Postoperative Nausea and Vomiting
Interventions: PROCEDURE: ST36 acupoint injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Cardiomyopathy, Hypertrophic
Interventions: DRUG: Mavacamten|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709)
Status: COMPLETED
Conditions: Insomnia|Sleep Initiation and Maintenance Disorders|Mental Disorders|Dyssomnias|Sleep Disorders
Interventions: DRUG: Esmirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Bone Marrow and Kidney Transplant for Multiple Myeloma With Kidney Failure
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Multiple Myeloma
Interventions: PROCEDURE: Combined bone marrow and kidney transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Salmeterol and Fluticasone Propionate Absorption From Salmeterol/Fluticasone Easyhaler With Seretide Diskus
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Seretide Diskus and charcoal|DRUG: Seretide Diskus|DRUG: SF Easyhaler and charcoal|DRUG: SF Easyhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Visual Outcomes After Bilateral Surgical Cataract Phacoemulsification: AcrySof Toric IOL Implantation Compared to Monofocal IOL Implantation
Status: TERMINATED
Conditions: Cataract
Interventions: DEVICE: Toric T3 - T9|DEVICE: Monofocal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Peer Navigator Model to Improve Quit Attempts and Smoking Cessation Rates Among HIV-positive Smokers
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Peer navigation social support for smoking cessation|BEHAVIORAL: Standard Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rectal Cancer, Adjuvant Chemotherapy, FOLFOX(5-fluorouracil/Leucovorin/Oxaliplatin), Total Mesorectal Excision
Status: UNKNOWN
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: Arm A : standard neoadjuvant chemoradiotherapy group|DRUG: Arm B : adjuvant FOLFOX group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Holmium Vs Trilogy Kidney Stones GUY's 1-2
Status: UNKNOWN
Conditions: Kidney Stone|Kidney Calculi|Kidney Diseases
Interventions: PROCEDURE: Fragmentation of calculi with 100 W Holmium laser or LithoClast Trilogy EMS and 1.5 mm x 440 mm probe, according to randomization.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Access the Metabolic Effects of Ranolazine in Subjects With Type 2 Diabetes Mellitus When Added to Ongoing Non-insulin Antidiabetic Therapy
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbial Transplantation for the Treatment of Fecal Incontinence in Women
Status: TERMINATED
Conditions: Fecal Incontinence
Interventions: BIOLOGICAL: fecal microbial transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Long-term Safety of BI 655130 in Patients With Atopic Eczema Who Took Part in Study 1368-0032
Status: TERMINATED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Spesolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefractive Keratectomy (PRK) in Keratoconus
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: Corneal Collagen Cross-Linking (CxL)|PROCEDURE: Corneal Collagen Cross-Linking combined with t-PRK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening for Uterine Cavity Abnormalities in Women Scheduled for IVF
Status: COMPLETED
Conditions: Infertility
Interventions: RADIATION: three dimensional ultrasound|DEVICE: Office hysteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of a Behavioral Treatment Program for Attention Deficit Hyperactivity Disorder, Inattentive Type
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: Parent Focused Training (PFT)|BEHAVIORAL: Child Life and Attention Skills (CLAS) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART)
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Vitamin D 3 cholecalciferol|DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of SARS-CoV-2 mRNA Vaccine (BNT162b2) in Chinese Healthy Population
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: BIOLOGICAL: BNT162b2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ONE PATH: Optimizing Nutrition Education for Parents and Teachers for Healthy Growth
Status: RECRUITING
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: CORE NAP SACC|BEHAVIORAL: ECE Provider|BEHAVIORAL: Parent Intervention|BEHAVIORAL: Child intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
Status: TERMINATED
Conditions: Acute Coronary Syndrome|Myocardial Infarction|Coronary Artery Disease|Percutaneous Coronary Intervention
Interventions: DRUG: CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin|DRUG: Plavix (clopidogrel 75 mg) and aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
Status: COMPLETED
Conditions: Impairment of Oral Perception|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Sucralose|DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Sucralose + maltodextrin|DIETARY_SUPPLEMENT: Sucralose + Sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lu AE58054 Added to Donepezil for the Treatment for Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Lu AE58054|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Sialic Acid in Patients With Glucosamine (UDP-N-acetyl)-2-epimerase Myopathy (GNEM) or Hereditary Inclusion Body Myopathy (HIBM)
Status: COMPLETED
Conditions: Hereditary Inclusion Body Myopathy|Distal Myopathy With Rimmed Vacuoles|Distal Myopathy, Nonaka Type|GNE Myopathy
Interventions: DRUG: aceneuramic acid extended-release (Ace-ER)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Ivacaftor in Subjects With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ivacaftor 25 mg/75 mg|DRUG: Ivacaftor 75 mg/150 mg|DRUG: Ivacaftor 150 mg or 250 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antimuscarinics as the First-line Treatment for Male With IPSS-V/S≤1
Status: COMPLETED
Conditions: Bladder Outlet Obstruction
Interventions: DRUG: Detrusitol 4 mg QD|DRUG: Doxazosin 4 mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.
Status: RECRUITING
Conditions: Eosinophilic Asthma|Asthma; Eosinophilic|Asthma
Interventions: DRUG: Dexpramipexole Dihydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Moderate to Severe Nasolabial Folds
Status: COMPLETED
Conditions: Correction of Moderate to Severe Nasolabial Folds (NLFs)
Interventions: DEVICE: Radiesse injectable implant (dermal filler)|DEVICE: Restylane injectable implant (dermal filler)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO)
Status: COMPLETED
Conditions: Moderate to Severe Gout|Hyperuricemia
Interventions: DRUG: Combination 400|DRUG: Allopurinol|DRUG: Combination 600
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation and Comparison of BCR-ABL p210 mRNA Transcripts (%IS Unit) Results Between Dr. PCR™ BCR-ABL1 Major IS Detection Kit (Optolane) and QXDx™ BCR-ABL %IS Kit (Bio-Rad) in Chronic Myeloid Leukemia Patients
Status: RECRUITING
Conditions: Chronic Myelogenous Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding
Status: COMPLETED
Conditions: Peptic Ulcer Hemorrhage
Interventions: DRUG: Tranexamic Acid Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Single-arm Trial of Prophylactic Tocilizumab for Acute GVHD Prevention After Haploidentical HSCT.
Status: RECRUITING
Conditions: Leukemia|Graft-versus-host-disease
Interventions: DRUG: Cytarabine|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Me-CCNU|DRUG: Rabbit antithymocyte globulin|DRUG: Tocilizumab|PROCEDURE: Allogeneic HSCT|DRUG: Cyclosporin A|DRUG: Mycophenolate Mofetil|DRUG: MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Comparative Bioavailability and Pharmacokinetics of ACM-001.1) and Pindolol in Healthy Volunteers (HV)
Status: COMPLETED
Conditions: Cachexia
Interventions: DRUG: Part 1 Group 1 Regime A (ACM-001.1)|DRUG: Part 1 Group 2 Regimen C (Pindolol)|DRUG: Part 2 Group D (Pindolol)|DRUG: Part 2 Group E (ACM-001.1)|DRUG: Part 2 Group F (ACM-001.1 )|DRUG: Part 2 Group G (ACM-001.1)|DRUG: Part 1 Group 1 Regimen B (Pindolol)|OTHER: Part 1 Group 1 Regimen A (Placebo)|OTHER: Part 2 Group E (Placebo)|OTHER: Part 2 Group F (Placebo)|OTHER: Part 2 Group G ( Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Characteristics, Treatment and Prognosis of Chest Tightness Variant Asthma
Status: COMPLETED
Conditions: Asthma|Chest Syndrome|Clinical Anxiety|Clinical Depression|Lung Function|Quality of Life|Eosinophilia|Nitric Oxide|Airway Responsiveness|Induced Sputum
Interventions: DRUG: Treat patient according to Global Initiative for Asthma (GINA) guideline
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MyHeart Counts Cardiovascular Health Study
Status: RECRUITING
Conditions: Cardiovascular Health
Interventions: BEHAVIORAL: Stand Prompt|BEHAVIORAL: Step Prompt|BEHAVIORAL: Cluster Prompt|BEHAVIORAL: Read AHA website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Neoadjuvant Sintilimab Plus FLOT Versus Sintilimab Plus SOX Phase II Clinical Trial for Patients With Locally Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Neoadjuvant Chemotherapy|Sintilimab|Locally Advanced Gastric Cancer
Interventions: DRUG: SOX+Sintilimab|DRUG: FLOT+Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin|DRUG: prednisone|DRUG: vincristine|RADIATION: tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Nonmalignant Neoplasm
Interventions: BIOLOGICAL: trivalent influenza vaccine|OTHER: Immunoenzyme technique|OTHER: Laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Imatinib and Peginterferon α-2b in Gastrointestinal Stromal Tumor (GIST) Patients
Status: TERMINATED
Conditions: Gastrointestinal Stromal Tumors|Cancer Brain|Solid Tumors
Interventions: DRUG: Peginterferon-alpha 2b (PegIFNa2b);|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)
Status: COMPLETED
Conditions: Anesthesia, Epidural
Interventions: PROCEDURE: Patient Controlled Epidural Analgesia for third trimester termination of preganancy analgesia|DRUG: Levobupivacaine|DRUG: sufentanil|DRUG: clonidine|DEVICE: epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Adult Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: LY2216684|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive-motor Intervention Using Virtual Reality for Middle-aged Individuals at High Dementia Risk
Status: UNKNOWN
Conditions: Alzheimer's Disease (AD)
Interventions: BEHAVIORAL: cognitive training by virtual reality|BEHAVIORAL: watching a scientific TV documentary|DEVICE: treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Menactra® in Children Aged 4 to 6 Years When Administered Concomitantly With a Fifth Dose of DAPTACEL®
Status: COMPLETED
Conditions: Meningococcal Meningitis|Tetanus|Diphtheria|Pertussis|Poliomyelitis
Interventions: BIOLOGICAL: Polysaccharide Diphtheria Toxoid Conjugate Vaccine|BIOLOGICAL: Polysaccharide Diphtheria Toxoid Conjugate Vaccine|BIOLOGICAL: Polysaccharide Diphtheria Toxoid Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: FPA150 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer|Endometrial Cancer|Advanced Solid Tumors
Interventions: BIOLOGICAL: FPA150|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS) to Assess the Efficacy, Safety and Tolerability of Glatiramer Acetate (GA) Injection 40 mg Administered Three Times a Week Compared to Placebo
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Glatiramer acetate (GA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Superior Trunk Block Catheter Versus Single-shot Superior Trunk Block With Intravenous Dexmedetomidine for Shoulder Arthroplasty
Status: COMPLETED
Conditions: Shoulder Arthroplasty|Postoperative Pain
Interventions: PROCEDURE: Single-shot superior trunk block with intravenous dexmedetomidine|PROCEDURE: Continuous superior trunk block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: First Line Treatment of Metastatic Colorectal Cancer With mFOLFOX6 in Combination With Regorafenib
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)|DRUG: Oxaliplatin|DRUG: Folinic acid|DRUG: 5-FU (mFOLFOX6)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT