pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trial of Erlotinib and BKM120 in Patients With Advanced Non Small Cell Lung Cancer Previously Sensitive to Erlotinib
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: BKM120 and Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Specific Training Program on the Neuromodulation of Pain in Fibromyalgia Subjects
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: thermode (TSA-II model)|OTHER: Adapted Physical Activity|OTHER: Physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation Of Safety, Tolerability And Pharmacokinetics Of Single And Multiple Doses Of PF-06730512
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-06730512|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Cryoablation for the Palliation of Painful Bone Metastases
Status: COMPLETED
Conditions: Pain|Neoplasm Metastasis
Interventions: PROCEDURE: Cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Skin Attributes Following Dietary Supplement Consumption
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Low dose Polyphenol|DIETARY_SUPPLEMENT: High dose Polyphenol|DIETARY_SUPPLEMENT: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Perioperative Adebrelimab and Chemotherapy in Esophageal and Esophagogastric Junction Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Adebrelimab|Esophageal Cancer|Perioperative Period
Interventions: DRUG: adebrelimab,Paclitaxel,Lobaplatin,Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbidopa for the Treatment of Excessive Blood Pressure Variability
Status: COMPLETED
Conditions: Dysautonomia, Familial|Baroreflex Failure Syndrome
Interventions: DRUG: Carbidopa Low-Dose|OTHER: Placebo|DRUG: Carbidopa High-Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma
Status: COMPLETED
Conditions: Ewing's Sarcoma|Ewing Family of Tumors|Ewing's Tumor Metastatic|Ewing's Sarcoma Metastatic|Ewing's Tumor Recurrent|Rare Diseases|Sarcoma
Interventions: BIOLOGICAL: pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yinhu Qingwen Granula for the Treatment of Severe CoVID-19
Status: SUSPENDED
Conditions: COVID-19|Severe Pneumonia|Chinese Medicine
Interventions: DRUG: Yinhu Qingwen Granula|DRUG: Yin Hu Qing Wen Granula(low does)|OTHER: standard medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise in Adolescents With Insulin Resistance
Status: RECRUITING
Conditions: Insulin Resistance
Interventions: OTHER: Hypercapnia|DEVICE: Transcranial Doppler|DEVICE: Cycle ergometer|OTHER: Cognitive Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Single and Multiple Intravenous Administrations of Estetrol (E4) in Healthy Adult Volunteers
Status: UNKNOWN
Conditions: Safety|Pharmacokinetics
Interventions: DRUG: single E4 30 mg|DRUG: single E4 100 mg|DRUG: multiple E4 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Novel Lung Function Parameters and Quantitative Computed Tomography (qCT) in Patients With Pulmonary Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Bronchial Asthma|Interstitial Lung Disease
Interventions: DEVICE: multiple breath washout test (MBW)|DEVICE: impulse oscillometry (IOS)|DEVICE: body plethysmography (BP)|DEVICE: quantitative computed tomography (qCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of One Versus Two Doses of Influenza Vaccine in Children 5-8 Years of Age
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: 2 0.5 ml doses of '04-05 Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treating Schizophrenia by Correcting Abnormal Brain Development
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Tiagabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing Colonoscopy
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Esketamine|DRUG: Esketamine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Study Comparing the Clinical Performance of Two Silicone Hydrogel Lenses Over 1 Month of Daily Wear
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: comfilcon A|DEVICE: lotrafilcon B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Amount of Meloxicam in the Blood When it is Taken as Capsules or as Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Meloxicam Capsule (Test)|DRUG: Meloxicam Tablet (Reference)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nucleoside (Acid) Analogues Treatment in Patients With Normal ALT and Positive HBVDNA.
Status: RECRUITING
Conditions: Hepatitis B Virus
Interventions: DRUG: Tenofovir alafenamide Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation Effect In Children With Pulmonary Tuberculosis Treatment
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary
Interventions: DIETARY_SUPPLEMENT: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Abuse Potential of Intranasal Cebranopadol
Status: NOT_YET_RECRUITING
Conditions: Abuse, Drug
Interventions: DRUG: Cebranopadol- 600 ug|DRUG: Cebranopadol- 800ug|DRUG: Cebranopadol- 1000ug|DRUG: Treatment A:|DRUG: Treatment B|DRUG: Treatment C|DRUG: Qualification|DRUG: Qualification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cereal-based Products Fortified With Legumes and Effects on Glycemic Control and Appetite Regulation
Status: COMPLETED
Conditions: Appetite
Interventions: OTHER: Cereal-legume product 1|OTHER: Cereal-legume product 2|OTHER: Cereal product|OTHER: Reference food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Feasibility of an Endotoxemia Model
Status: COMPLETED
Conditions: Cardiovascular Disease|Inflammation
Interventions: DRUG: LPS (reference endotoxin, E. coli O113:H10:K:neg, manufactured under GMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Investigating the Impact of Tailored Reports on Anxiety Amongst Cancer Patients and Their Confidants
Status: COMPLETED
Conditions: Breast Neoplasms|Prostatic Neoplasms|Laryngeal Neoplasms|Cervix Neoplasms
Interventions: PROCEDURE: Issue of information booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: Apathy Cure Through Bupropion in Huntington's Disease
Status: COMPLETED
Conditions: Apathy|Huntington's Disease
Interventions: DRUG: Bupropion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Extension Trial to Assess the Safety of Long-Term Treatment of Rotigotine in Early-Stage Parkinson's Disease.
Status: COMPLETED
Conditions: Early-Stage Parkinson's Disease
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Comfort and Blur of Systane Ultra and Systane
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: Systane Ultra Lubricant Eye Drops|OTHER: Systane Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab in Patients With Advanced Gynaecological Clear Cell Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Clear Cell Tumor|Gynecologic Cancer|Advanced Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas
Status: RECRUITING
Conditions: Bone Sarcoma|Osteosarcoma|Chondrosarcoma|Ewing's Sarcoma|Osseous Sarcoma|Bone Neoplasm
Interventions: BEHAVIORAL: Toronto Extremity Salvage Score|BEHAVIORAL: Musculoskeletal Tumor Society Score|BEHAVIORAL: Timed Get Up and Go Test|DIAGNOSTIC_TEST: Orthogonal Radiographs|DIAGNOSTIC_TEST: Weight Bearing for lower extremities only|DIAGNOSTIC_TEST: Range of Motion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trunk and Upper Extremities Program Effect in Decreasing Compensation Patterns in Unilateral Cerebral Palsy Children
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy Infantile|Chronic Pain|Upper Extremity Dysfunction
Interventions: OTHER: TUPEX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Rozanolixizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pictorial Warning Labels and Memory for Relative and Absolute Cigarette Health-risk Information Over Time in Teens
Status: COMPLETED
Conditions: Smoking Cessation|Smoking, Cigarette
Interventions: BEHAVIORAL: text-only PWL|BEHAVIORAL: graphic PWL|BEHAVIORAL: absolute risk|BEHAVIORAL: relative risk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Safety Study With Intravitreal (IVT) REGN2176-3 in Patients Aged 50 Years and Older With Wet AMD
Status: COMPLETED
Conditions: Neovascular Wet Age-related Macular Degeneration (AMD)
Interventions: DRUG: REGN2176-3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: cTACE Plus Sintilimab for Unresectable Intermediate-stage HCC With Beyond Up-to-seven Criteria
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Sintilimab|DEVICE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety and Efficacy of CHO-H01 as a Single Agent/Combined With Lenalidomide in Subjects With Refractory or Relapsed Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: CHO-H01|DRUG: CHO-H01 at RP2D|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Study to Characterize the REAL-WORLD EVIDENCE Regarding Safety and Performance of the PTCA Catheters Family
Status: COMPLETED
Conditions: Coronary Artery Stenosis
Interventions: PROCEDURE: Percutaneous Transluminal Coronary Angioplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Different Colorectal Cancer Screening Strategies
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DIAGNOSTIC_TEST: Fecal immunochemical test|DIAGNOSTIC_TEST: APCS score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion
Status: UNKNOWN
Conditions: Image Changes of Lumbar Fusion|Bone Turnover Markers|Bone Mineral Density
Interventions: DRUG: zoledronic acid|DRUG: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Digital Therapeutic Solution for Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Prostate Cancer|Colorectal Cancer|Lung Cancer
Interventions: DEVICE: A digital solution for patients with Cancer|OTHER: Standard of care for patients with Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Fluid Transfer Through the Skin, by Increased Sweat Rate, on Hemodialysis Patients
Status: COMPLETED
Conditions: Acute Kidney Failure|Chronic Kidney Diseases
Interventions: DEVICE: The AquaPass System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Age 12 Follow-up of Early Preventive Intervention (Memphis)
Status: COMPLETED
Conditions: Child Rearing|Reproductive Behavior|Risk Reduction Behavior
Interventions: BEHAVIORAL: home visitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Irofulven in Treating Patients With Recurrent or Persistent Ovarian Epithelial or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Primary Peritoneal Cavity Cancer|Recurrent Ovarian Epithelial Cancer
Interventions: DRUG: irofulven
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study for Rivaroxaban in Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Myocardial Infarction|Myocardial Ischemia|Unstable Angina
Interventions: DRUG: Rivaroxaban 2.5 mg|DRUG: Rivaroxaban 5 mg|DRUG: Placebo|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Add-on Effectiveness of EA or TENS in Early Postpartum Breast Engorgement
Status: TERMINATED
Conditions: Breast Engorgement in Puerperium|Post Partum Depression
Interventions: OTHER: Routine care|PROCEDURE: Electrical Acupuncture|PROCEDURE: Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.
Status: COMPLETED
Conditions: Facial Wrinkles
Interventions: DEVICE: Belotero|DEVICE: Zyplast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Survodutide Helps Japanese People Living With Obesity Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: Survodutide|DRUG: Placebo matching survodutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Digital Team-based Communication on Patient-initiated Telephone Contacts to Hospital After Discharge
Status: COMPLETED
Conditions: Orthopaedic Surgery
Interventions: OTHER: Standard communication pathways after discharge|OTHER: Digital team-based communication after discharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dexmedetomidine to Lessen Intensive Care Unit (ICU) Agitation
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Skin and Plasma Pharmacokinetic of Multiple Doses of Povorcitinib After Oral Administration in Healthy Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Povorcitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of 11-oxygenated Androgens on Metabolic Dysfunction of Women With Polycystic Ovary Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: oral androgen challenge with dehydroepiandrosterone (DHEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Intravenous V/S Nasal Atomizer Delivery of Midazolam for Conscious Sedation for No-scalpel Vasectomy
Status: COMPLETED
Conditions: Vasectomy|Sedation
Interventions: DEVICE: midazolam by nasal atomizer|DRUG: intravenous midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Risk of Nocturnal Hypoglycemia and Arrhythmias With Sitagliptin Versus Glimepiride in Patients With Type 2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Sitagliptin|DRUG: Glimepiride|DRUG: Sitagliptin-Placebo|DRUG: Glimepiride-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Narcotic-Free Percutaneous Nephrolithotomy
Status: RECRUITING
Conditions: Nephrolithiasis
Interventions: DRUG: 5mg Oxycodone, Q6 PRN|DRUG: 10mg Ketorolac, Q6 PRN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of One Dose of an Inactivated Trivalent Sub-unit Influenza Vaccine Administered to Non-elderly Adult and Elderly Subjects
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Seasonal Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Development of a New Method for Steady-State Measurement of NO Lung Diffusing Capacity in Healthy Subjects
Status: UNKNOWN
Conditions: Pulmonary Diffusing Capacity
Interventions: DRUG: Nitric oxide, Carbon monoxide, Helium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of a Supervised Home-based Tele-rehabilitation Program on Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Telerehabilitation
Interventions: OTHER: Telerehabilitation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Generic Tazarotene Cream, 0.05% for the Treatment of Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Tazarotene Cream, 0.05%|DRUG: Vehicle|DRUG: Reference: Tazorac Cream, 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis.
Status: UNKNOWN
Conditions: Knee Osteoarthristis
Interventions: BIOLOGICAL: Human amniotic suspension allograft (ASA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Way to Quit - Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: Individual Rewards|BEHAVIORAL: Fixed Deposits|BEHAVIORAL: Competitive Deposits (Pari-Mutuel)|BEHAVIORAL: Collaborative Rewards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PVB Versus TAP in Hepatic Patients Undergoing Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Ultrasound Therapy|Hepatic Impairment|Laparoscopic Cholecystectomy
Interventions: OTHER: ultrasound-guided nerve block PVB|OTHER: ultrasound-guided nerve block TAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Acupressure in Treating Nausea in Women Receiving Combination Chemotherapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Drug-induced Nausea and Vomiting
Interventions: PROCEDURE: acupressure therapy|PROCEDURE: management of therapy complications|PROCEDURE: nausea and vomiting therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Jigsaw Technique on Childhood Epileptic Seizure Management Knowledge and Attitudes of Nursing Students
Status: COMPLETED
Conditions: Jigsaw Technique|Epilepsy in Children|Nursing Student
Interventions: OTHER: Training method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Peritoneal Metastases in Patients Undergoing Cytoreductive Surgery
Status: COMPLETED
Conditions: Peritoneal Carcinomatosis
Interventions: DRUG: pegsitacianine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Re-Irradiation of Progressive or Recurrent DIPG
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent or Progressive Diffuse Intrinsic Pontine Glioma
Interventions: RADIATION: re-irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Control of Tracheal Cuff Pressure and Microaspiration in Critically Ill Patients
Status: COMPLETED
Conditions: Critically Ill
Interventions: DEVICE: Continuous control of cuff pressure|DEVICE: Manual control of cuff pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Evaluate the Observance Rehabilitation of Upper Limbs by Visual-motor Simulation Associated at Transcranial Direct Current Stimulation (tDCS) in Hemiparetic Patient Post-stroke
Status: TERMINATED
Conditions: Stroke
Interventions: DIAGNOSTIC_TEST: transcranial Direct Current Stimulation (tDCS)|DIAGNOSTIC_TEST: Computerized Mirror Therapy (CMT)|DIAGNOSTIC_TEST: Tolerance Assessment Questionnaire|DIAGNOSTIC_TEST: Ashworth's scale|DIAGNOSTIC_TEST: Frenchay arm test|DIAGNOSTIC_TEST: Abilhand questionnaire|DIAGNOSTIC_TEST: Fugl-Meyer test|DIAGNOSTIC_TEST: Goal Attainment Scaling (GAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Characterization of the Prosocial and Prosexual Effects of GHB
Status: COMPLETED
Conditions: Depressive Disorder, Major|Bipolar Disorder|Autistic Disorder
Interventions: DRUG: GHB 35 mg/kg p.o.|DRUG: GHB 20 mg/kg p.o.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study Using FolateScan to Identify Subjects With Folate Receptor-Positive Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Technetium Tc 99m EC20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy
Status: COMPLETED
Conditions: Charcot Joint of Foot
Interventions: DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility - Beta Adrenergic Blockade (BB) in Cervical Cancer (CX)
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: Propranolol|BEHAVIORAL: Diary|BEHAVIORAL: Relaxation Audio Recording|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multicenter, Randomized, Double-blind, Three-arm, Parallel Clinical Endpoint Bioequivalence Study of Monometasone Furoate Nasal Spray in Patients With Seasonal Allergic Rhinitis
Status: RECRUITING
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Mometasone furoate as a nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RATNO, Reducing Antibiotic Tolerance Using Nitric Oxide in CF - a Phase 2 Pilot Study
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Nitric Oxide|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Dose Audit Reports to Reduce Radiation Exposure From CT Exams
Status: COMPLETED
Conditions: Decrease Variability and Amount of Radiation Dose From CT Exams
Interventions: BEHAVIORAL: Radiation Dose Audit Reports|BEHAVIORAL: Educational Seminar: Radiation Dose Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
Status: COMPLETED
Conditions: Excessive Daytime Sleepiness|Narcolepsy|Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
Interventions: DRUG: Armodafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A VSA003 Phase 1 Study in Chinese Adult Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Dyslipidemias|Familial Hypercholesterolemia|Hypertriglyceridemia
Interventions: DRUG: VSA003|DRUG: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste
Status: COMPLETED
Conditions: Gingivitis|Plaque, Dental
Interventions: DRUG: Test|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Same-session MR-only Simulation and Treatment With MRI-guided Adaptive Palliative RadioTherapy
Status: COMPLETED
Conditions: Malignancy|Metastasis|Hemoptysis|Gastrointestinal Bleeding|Pelvic Bleeding|Superior Vena Cava Syndrome|Mediastinal Disease
Interventions: DEVICE: Volumetric MR imaging|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Root Roughness and Smear Layer Formation Using Conventional and Contemporary Dental Curettes
Status: COMPLETED
Conditions: Dental Calculus
Interventions: DEVICE: Control group|DEVICE: Gracey Curette|DEVICE: After Five|DEVICE: Mini Five
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LycoRed 40051 Product as a Countermeasure to Exercise Stress
Status: COMPLETED
Conditions: Inflammation
Interventions: DIETARY_SUPPLEMENT: LycoRed (code 40051) product|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PTSD Prevention Using Oral Hydrocortisone
Status: RECRUITING
Conditions: PTSD|Acute Stress Disorder|Trauma-related Stressor
Interventions: DRUG: Placebo|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of SHR0302 Tablets (SHR0302) as Monotherapy in Active Rheumatoid Arthritis (RA) Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SHR0302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Botanical Oil Supplementation in Diabetic and Metabolic Syndrome Subjects
Status: COMPLETED
Conditions: Diabetes|Metabolic Syndrome x
Interventions: DRUG: borage/echium oil combination|DIETARY_SUPPLEMENT: fish oil|DIETARY_SUPPLEMENT: corn oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gastrointestinal Postoperative Early Enteral Nutrition: Immuno-enhanced Versus Standard Early Enteral Nutrition
Status: UNKNOWN
Conditions: Gastrointestinal Malignant
Interventions: DRUG: Immuno-enhanced|DRUG: Standard early enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ocsaar and CYP2C9 Ploymorphism, Is There a Connection Between Pharmacokinetics, Pharmacodynamics and Pharmacogenetics?
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: losartan|DRUG: valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Comparison of Intermittent Androgen Deprivation Therapy With or Without Irradiation Recovery in Prostate Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Oligometastasis
Interventions: DRUG: IADT|COMBINATION_PRODUCT: IADT + radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of DDP733 for IBS-c
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Constipation|Irritable Bowel Syndrome
Interventions: DRUG: DDP733
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Bilateral Versus Unilateral Lower Limb Training on Balance and Gait Parameters in Stroke Patients
Status: COMPLETED
Conditions: Stroke, Ischemic|Balance; Distorted|Gait, Hemiplegic
Interventions: OTHER: Unilateral training group (UTG)|OTHER: Bilateral training group (BTG).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Effect of a Mineral-enriched Powder on Iron Deficiency in Women of Reproductive Age
Status: RECRUITING
Conditions: Iron Deficiency|Iron Deficiency Anaemia
Interventions: OTHER: Mineral-enriched powder|OTHER: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tumor Response to Ipilimumab in the Treatment of Melanoma With Brain Metastases
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Corticosteroid: Betamethasone|DRUG: Corticosteroid: Dexamethasone|DRUG: Corticosteroid: Fludrocortisone|DRUG: Corticosteroid: Hydrocortisone|DRUG: Corticosteroid: Meprednisone|DRUG: Corticosteroid: Methylprednisolone|DRUG: Corticosteroid: Prednisolone|DRUG: Corticosteroid: Prednisone|DRUG: Corticosteroid: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae
Status: COMPLETED
Conditions: Urinary Tract Infection, Complicated|Acute Pyelonephritis|Hospital Acquired Bacterial Pneumonia|Ventilator-associated Bacterial Pneumonia|Bacteremia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Cisapride in Premature Infants With Feeding Problems
Status: TERMINATED
Conditions: Infant, Premature|Infant, Newborn
Interventions: DRUG: Placebo|DRUG: Cisapride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetics of Antiepileptic in Pediatrics
Status: RECRUITING
Conditions: Epilepsy
Interventions: BIOLOGICAL: Valproic acid|BIOLOGICAL: carbamazepine|BIOLOGICAL: phenobarbital|BIOLOGICAL: phenytoin|BIOLOGICAL: levetiracetam|BIOLOGICAL: lamotrigine|BIOLOGICAL: topiramate|BIOLOGICAL: oxcarbazepine|BIOLOGICAL: stiripentol|BIOLOGICAL: clobazam|BIOLOGICAL: brivaracétam|BIOLOGICAL: felbamate|BIOLOGICAL: lacosamide|BIOLOGICAL: rufinamide|BIOLOGICAL: gabapentine|BIOLOGICAL: pregabaline|BIOLOGICAL: sultiame|BIOLOGICAL: tiagabine|BIOLOGICAL: vigabatrine|BIOLOGICAL: mesuximide|BIOLOGICAL: primidone|BIOLOGICAL: perampanel|BIOLOGICAL: ethosuximide|BIOLOGICAL: zonisamide|BIOLOGICAL: cannabidiol|OTHER: genetic polymorphisms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Retinopathy
Interventions: DRUG: Ketorolac 0.45% ophthalmic solution|DRUG: Placebo - Preservative-free artificial tears|OTHER: Aqueous PGE2 and inflammatory cytokines measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Drug-Drug Interaction of Cladribine and Pantoprazole in Multiple Sclerosis Subjects
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Cladribine|DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Denosumab for Prevention of Post-Teriparatide Bone Loss in Premenopausal Women With IOP
Status: COMPLETED
Conditions: Adult Idiopathic Generalized Osteoporosis
Interventions: DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Single-center Study to Investigate How Quickly and to What Extent a Radioactive Dose of RO5285119 is Absorbed, Metabolized and Eliminated From the Body of Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO5285119
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Constraint-induced Movement Therapy and Hand Arm Bimanual Training in Children With Hemiplegic Cerebral Palsy (CP)
Status: UNKNOWN
Conditions: Cerebral Palsy|Hand Function
Interventions: OTHER: CIMT+HABIT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRI Study of BAY 43-9006 in Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: placebo|DRUG: Sorafenib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nipocalimab With Co-administration of Etanercept or Hydroxychloroquine in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nipocalimab|DRUG: Etanercept|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of a Perioperative Action Observation and Motor Imagery Training in Patients Undergoing Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Total Knee Arthoplasty
Interventions: BEHAVIORAL: Action observation and motor imagery|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Islet Transplantation Using Campath-1H and Infliximab Induction
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: alemtuzumab|PROCEDURE: islet transplant|DRUG: infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: OPC-34712|DRUG: Placebo|DRUG: ADT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Immunogenicity & Safety of GSK Bio's DTPa-HBV-IPV/Hib (Mixed Vaccine) and DTPa-IPV/Hib + HBV Vaccines
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Infanrix-Hexa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
Status: NOT_YET_RECRUITING
Conditions: Aphasia|Stroke
Interventions: DEVICE: Anodal transcranial direct current stimulation|DEVICE: Sham transcranial direct current stimulation|BEHAVIORAL: Speech-Language Therapy (SLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Metacognitive Skills Training in the Context of Forensic Psychiatric Care
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder|Psychotic Disorders|Delusional Disorder|Psychotic Depression
Interventions: BEHAVIORAL: Metacognitive Skills Training (MCT)|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of KN026 in Combination With HB1801 in the First-line Treatment of Subjects With HER2-positive Recurrent or Metastatic Breast Cancer.
Status: NOT_YET_RECRUITING
Conditions: First-line Treatment of HER2-positive Recurrent or Metastatic Breast Cancer
Interventions: DRUG: KN026|DRUG: HB1801|DRUG: Pertuzumab|DRUG: Trastuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Treatment of Children With Purpura Nephritis With Huaiqihuang Granules
Status: UNKNOWN
Conditions: Henoch Schönlein Purpura Nephritis
Interventions: DRUG: Huaiqinhuang|DRUG: valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SafERteens M-Coach
Status: COMPLETED
Conditions: Alcohol Drinking|Violence
Interventions: BEHAVIORAL: Step 1 Treatment BI+HC|BEHAVIORAL: Step 1 Treatment BI+TM|BEHAVIORAL: Step 2 Treatment Responders|BEHAVIORAL: Step 2 Treatment Non-Responders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of 3 Months of Supervised Exercise Training
Status: UNKNOWN
Conditions: Overweight/Obesity|Glucose Intolerance|Type 2 Diabetes|Sedentarity
Interventions: BEHAVIORAL: Behavior: Supervised physical training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Lactobacillus Rhamnosus (JB-1) on Stress and Cognition
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus Rhamnosus (JB-1)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis
Status: COMPLETED
Conditions: Acute Pancreatitis|Intra-abdominal Hypertension
Interventions: DRUG: early enteral nutrition|DRUG: Delayed enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Dapagliflozin in Combination With Metformin on Body Weight in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Metformin|DRUG: Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/1b Study of ZH9 Treatment in Patients With Non-Muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: NMIBC|High Risk NMIBC|Non Muscle Invasive Bladder Cancer
Interventions: DRUG: ZH9
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot Study
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: clomiphene plus gonadotropins|DRUG: Leuprolide flare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Endometrial Cancer Chemoprevention Study of Metformin
Status: COMPLETED
Conditions: Gynecology
Interventions: DRUG: Metformin|OTHER: Placebo|PROCEDURE: Endometrial Biopsy|BEHAVIORAL: Lifestyle Intervention|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing
Status: UNKNOWN
Conditions: Venous Ulcer|Foot Ulcer, Diabetic
Interventions: BIOLOGICAL: Becaplermin|DEVICE: Promagran Dressing|DEVICE: Placebo Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Pilot Clinical Trial of Omega-3 Supplement vs. Placebo for Post Covid-19 Recovery Among Health Care Workers
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Omega-3 (EPA+DHA)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT