pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Vaginal Axis on Magnetic Resonance Imaging After Laparoscopic Pectopexy Surgery: a Controlled Study
Status: RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: laparoscopic pectopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)
Status: RECRUITING
Conditions: Mesotheliomas Pleural
Interventions: DRUG: Pembrolizumab|PROCEDURE: Indocyanine Green (ICG) Image-Guided Surgery|DRUG: Cisplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Sunitinib, Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Sunitinib|DRUG: Temozolomide|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Retinopathy of Prematurity|Bronchopulmonary Dysplasia (BPD)
Interventions: DRUG: Inositol lower volume|DRUG: Inositol mid-level volume|DRUG: Inositol high volume|DRUG: Placebo low volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ClAraC or FLAMSA Followed by Stem Cell Transplantation to Treat High Risk AML or Advanced MDS
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|MDS
Interventions: DRUG: Clofarabine, ara-C|DRUG: FLAMSA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EMD 525797 in Combination With Cetuximab and Irinotecan in K-ras Wild Type Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: EMD 525797 250 mg|DRUG: EMD 525797 500 mg|DRUG: EMD 525797 750 mg|DRUG: EMD 525797 1000 mg|DRUG: Cetuximab|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desmopressin Melt: Impact on Sleep and Daytime Functioning
Status: COMPLETED
Conditions: Monosymptomatic Nocturnal Enuresis
Interventions: DRUG: Desmopressin lyophilisate (Melt)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personality Profile of Children and Adolescents With ADHD and With or Without Emotional Dysregulation
Status: COMPLETED
Conditions: Attention Deficit Disorder|Emotional Dysfunction
Interventions: OTHER: Evaluation of the CBCL-A-A-A and HiPIC in children with ADHD and with ED or without ED
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Bioavailability of a New Tablet Formulation of Minzasolmin and the Effect of Food in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Minzasolmin tablet formulation under fasting condition|DRUG: Minzasolmin Granules in capsule under fasting condition|DRUG: Minzasolmin tablet formulation under fed condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Glucagon In the Prevention of Hypoglycemia During Mild Exercise
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Bihormonal Bionic Pancreas|DEVICE: Insulin Only Bionic Pancreas|DRUG: Glucagon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PLX3397, Radiation Therapy, and Antihormone Therapy in Treating Patients With Intermediate- or High-Risk Prostate Cancer
Status: COMPLETED
Conditions: Stage I Prostate Adenocarcinoma|Stage II Prostate Adenocarcinoma|Stage III Prostate Adenocarcinoma
Interventions: DRUG: Antiandrogen Therapy|OTHER: Laboratory Biomarker Analysis|DRUG: Multitargeted Tyrosine Kinase Inhibitor PLX3397|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Turmeric Anti-Inflammatory and Cell-Damage Trial
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Placebo comparator|DIETARY_SUPPLEMENT: Curcumin|DIETARY_SUPPLEMENT: Turmeric powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Colecalciferol Substitution in Dialysis Patients
Status: COMPLETED
Conditions: RENAL INSUFFICIENCY, CHRONIC|Hyperparathyroidism, Secondary
Interventions: DRUG: Colecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Eptinezumab in Participants With Episodic Cluster Headache
Status: COMPLETED
Conditions: Cluster Headache, Episodic
Interventions: DRUG: Eptinezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia
Status: COMPLETED
Conditions: Spinocerebellar Ataxia
Interventions: DEVICE: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pain Quality in Young Swimmers Suffering From Myofascial Pain Syndrome Using Lidocaine Phonophoresis
Status: COMPLETED
Conditions: Neck Pain
Interventions: DEVICE: pulsed ultrasound|OTHER: myofascial release|DEVICE: lidocaine phonophoresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind Comparison of Placebo and Atomoxetine Hydrochloride Given Once a Day in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety Pharmacokinetics of a Human Monoclonal Antibody S315 Against Diphtheria Toxin in Healthy Subjects
Status: COMPLETED
Conditions: Diphtheria
Interventions: DRUG: S315|DRUG: 0.9% Sodium Chloride (NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peptide Vaccination for Patients at High Risk for Recurrent Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Glycoprotein 100 (GP100): 209-217 (210M)|DRUG: Interleukin-2 (IL-2)|DRUG: Montanide ISA 51|DRUG: Melanoma antigen recognized by T-cells (MART)-1: 27-35|DRUG: 27-35 (27L): melanoma antigen recognized by T-cells (MART)-1|DRUG: melanoma antigen recognized by T-cells (MART)-1: 26-35(27L)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Ideal Sequence of Hybrid Coronary Revascularization With Endoscopic Coronary Revascularization
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Standard hybrid coronary revascularization|PROCEDURE: Reverse hybrid coronary revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplemental Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter
Status: COMPLETED
Conditions: Coronary Occlusion
Interventions: DEVICE: NovaCross™ Chronic Total Occlusion micro-catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ENERGITO® 2 Study Compares 2 Inhaled Medicines for Chronic Obstructive Pulmonary Disease (COPD). One Medicine is a Combination of Tiotropium and Olodaterol (Stiolto®) Taken Using the Respimat® Inhaler and the Other Medicine is a Combination of Fluticasone and Salmeterol Taken Using the Diskus
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium|DRUG: Olodaterol|DRUG: Fluticasone propionate|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Telbivudine and Tenofovir Disoproxil Fumarate Treatment on the Hepatitis B Virus DNA Kinetics in CHB
Status: COMPLETED
Conditions: Hepatitis B Virus
Interventions: DRUG: Telbivudine|DRUG: Tenofovir|DRUG: Telbivudine plus tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Rosiglitazone on Renal Hemodynamics and Proteinuria of Type 2 Diabetic Patients With Renal Insufficiency Due to Overt Diabetic Nephropathy
Status: COMPLETED
Conditions: Type 2 Diabetes|Overt Diabetic Nephropathy
Interventions: DRUG: Rosiglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Immediate Versus Early and Selective Invasive Percutaneous Coronary Intervention in NSTEMI
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Timing of percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Level of Expression and Prognostic Value of CXCL4, CXCL4L1 and CXCR3 in Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma|Carcinoma Renal Cell|Kidney Neoplasms|Kidney Diseases|Chemokines
Interventions: BIOLOGICAL: Biological sample|BIOLOGICAL: Biological sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1 Study of SHR-A2102 in Subjects With Advanced Solid Tumors.
Status: RECRUITING
Conditions: Advanced Or Metastatic Solid Tumor Malignancies
Interventions: DRUG: SHR-A2102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMART Study (Sellick's Maneuver Assisted Real Time) to Deliver Target Cricoid Pressure in Simulated Environment
Status: COMPLETED
Conditions: Pulmonary Aspiration of Gastric Contents
Interventions: DEVICE: Cricoid force sensor monitor system|DEVICE: Sham Cricoid force sensor monitor system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Intrathecal Morphine in Robot-assisted Prostatectomy
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: The intravenous patient-controlled analgesia|DRUG: The intrathecal morphine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Game-Based Rehabilitation Platform for Children With Neurodevelopmental Disorders and Acquired Brain Injuries
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: computer game based rehabilitation protocol|OTHER: Conventional therapy protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis
Status: COMPLETED
Conditions: Familial Amyloid Polyneuropathy
Interventions: DRUG: Fx-1006A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Device for Surveillance of Vascular Access Sites for Bleeding
Status: COMPLETED
Conditions: Dialysis; Complications|Wound Complication|Catheter Complications|Hemorrhage|Bleeding Wound
Interventions: DEVICE: Application of device which monitors for bleeding - Blood Warning Technology with Continuous Hemoglobin sensor (BWATCH)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Endoscopic Surgery in the Treatment of Soft Tissue Sarcoma in Nasal and Paranasal Sinus
Status: RECRUITING
Conditions: Sarcoma,Soft Tissue|Nasal Cavity Cancer|Paranasal Sinus Cancer|Surgery
Interventions: PROCEDURE: endoscopic surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of the Efficacy of Intravenous Immunoglobulin for Treating Women With Unexplained Secondary Recurrent Miscarriage
Status: COMPLETED
Conditions: Secondary Recurrent Miscarriage
Interventions: DRUG: Intravenous immunoglobulin|DRUG: Human albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Ovarian Autotransplantation
Status: COMPLETED
Conditions: Ovarian Autotransplantation Using Cryopreserved Ovarian Tissue in Women Treated for Cancer
Interventions: PROCEDURE: Ovarian autotransplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Heat Therapy and Strength Training Effects in Individuals With Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: Heat Therapy|OTHER: StrengthTraining|OTHER: Sedentary Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Water Injection Temperatures on the Safety and Comfort of Patients Undergoing Ultrasound Endoscopy of Small Probes Under Intravenous Anesthesia
Status: UNKNOWN
Conditions: Small Probe Ultrasound Endoscopy|The Water Temperature
Interventions: OTHER: Change the water injection temperature
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Influence of Electronic and Traditional Cigarettes Smoking on Hemodynamic Parameters
Status: UNKNOWN
Conditions: Tobacco; Use, Harmful
Interventions: OTHER: Baseline|DEVICE: e-cigarette without nicotine|DEVICE: e-cigarette with nicotine|DEVICE: traditional cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Remission of Type 2 Diabetes Via Calorie Restriction
Status: ENROLLING_BY_INVITATION
Conditions: Type 2 Diabetes|Obesity, Morbid
Interventions: BEHAVIORAL: Calorie restriction via total food replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Treatment With a Glycine Uptake Inhibitor in Participants With Negative Symptoms of Schizophrenia (P05695) (MK-8435-001)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: MK-8435 (Org 25935) 4-8 mg|DRUG: Placebo|DRUG: MK-8435 (Org 25935) 12-16 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BAY43-9006 Phase II Study for Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Nexavar (Sorafenib, BAY43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Anticoagulation With a Reduced Dose Regimen of Rivaroxaban in End-stage Renal Disease Patients
Status: UNKNOWN
Conditions: Chronic Hemodialysis Patients
Interventions: DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mucosal Impedance and Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DEVICE: Mucosal Impedance|PROCEDURE: Upper Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Post Operative Quality of Life and Pain in Ankle Fractures: Cast Versus Functional Treatment
Status: TERMINATED
Conditions: Ankle Fractures
Interventions: OTHER: Functional mobilisation|OTHER: Short term plaster cast fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Prophylaxis in Children With Pyelonephritis
Status: WITHDRAWN
Conditions: Pyelonephritis
Interventions: DRUG: Trimethoprim Sulfamethoxazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Test to Aczone 7.5% and Both to a Placebo Control in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Dapsone gel 7.5% (Torrent Pharmaceuticals Ltd)|DRUG: ACZONE® (dapsone) gel, 7.5% (Allergan, INC.)|OTHER: Placebo for Dapsone gel 7.5% (Torrent Pharmaceuticals Ltd)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Brain Stimulation and Cognitive Training for Depressive Symptomatology Related to Breast Cancer (ONCODEP)
Status: RECRUITING
Conditions: Depressive Symptoms|Cognitive Impairment
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: Transcranial Alternating Current Stimulation|DEVICE: tES sham|DEVICE: Online Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute and Chronic Effects of 100% Florida Orange Juice Consumption on Cognitive Performance in 7-10 Year Old Children
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 100% Florida OJ|DIETARY_SUPPLEMENT: Placebo Equicaloric Orange Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial of Camrelizumab Combined With Famitinib Malate in Treatment Naïve Subjects With PD-L1-Positive Recurrent or Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: camrelizumab + famitinib|DRUG: pembrolizumab|DRUG: camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of orBec® With Prednisone Therapy in the Treatment of Patients With Graft Versus Host Disease (GVHD)
Status: TERMINATED
Conditions: Acute Gastrointestinal Graft vs Host Disease
Interventions: DRUG: oral beclomethasone 17,21-dipropionate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab for Relapsed Acute B Lymphoblastic Leukemia After Transplantation
Status: RECRUITING
Conditions: Acute B-cell Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of ABT-288 in Subjects With Mild-to-Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ABT-288|DRUG: donepezil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular Tachycardia
Status: COMPLETED
Conditions: Tachycardia, Ventricular
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine
Status: RECRUITING
Conditions: Chronic Migraine in Children
Interventions: DRUG: Eptinezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single-session tDCS in Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Perinatal Stroke|Periventricular Leukomalacia
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Addition of Fecal Microbiota Transplant (FMT) and Plasma Exchange to Tenofovir in Comparison to Monotherapy With Tenofovir in ACLF-HBV
Status: UNKNOWN
Conditions: Acute-On-Chronic Liver Failure|Hepatitis B
Interventions: BIOLOGICAL: Plasma Exchange|DRUG: Tenofovir|OTHER: Fecal Mircobiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Lateral Position and Prone Position for Endoscopic Retrograde Cholangiopancreatography
Status: COMPLETED
Conditions: Choledocholithiasis
Interventions: PROCEDURE: Endoscopic retrograde cholangiopancreatography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Crizotinib|PROCEDURE: Radiologic Examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis|Conjunctivitis
Interventions: DRUG: REGN5713|DRUG: REGN5714|DRUG: REGN5715|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Quizartinib in Treating Patients With FLT3-mutated Recurrent or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia With FLT3/ITD Mutation|Recurrent Acute Myeloid Leukemia|Refractory Acute Leukemia
Interventions: DRUG: Quizartinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of CPAP Therapy on Pulmonary Function Test in Patients With COPD-OSA Overlap Syndrome
Status: COMPLETED
Conditions: COPD|OSA|Lung Function Decreased
Interventions: DEVICE: CPAP therapy|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Very Low-calorie Protein-based Versus Hypocaloric Enteral Nutrition
Status: UNKNOWN
Conditions: Perioperative/Postoperative Complications
Interventions: OTHER: Very low-calorie protein-based diet|OTHER: Hypocaloric diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Tapering in JIA With Inactive Disease
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: etanercept|DRUG: adalimumab|DRUG: Abatacept|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Tolerability and Efficacy of PBGM01 in Pediatric Participants With GM1 Gangliosidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: GM1 Gangliosidosis|GM1 Gangliosidosis, Type I|GM1 Gangliosidosis, Type 2|Beta-Galactosidase-1 (GLB1) Deficiency
Interventions: BIOLOGICAL: PBGM01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vein Ablation of Atrial Fibrillation Using Magnetic Navigation: Single Ring Versus Circumferential Techniques
Status: COMPLETED
Conditions: Pulmonary Vein Isolation, Ablation Time, Procedure Time, Freedom Form Atrial Fibrillation
Interventions: PROCEDURE: Circumferential pulmonary vein ablation|PROCEDURE: single ring pulmonary vein ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Inulin on Satiety and Food Intake
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: inulin|DIETARY_SUPPLEMENT: inulin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Treatment of Prolonged Uterine Bleeding of Etonogestrel (ENG)-Releasing Implant
Status: RECRUITING
Conditions: Breakthrough Bleeding
Interventions: DRUG: Norethisterone 10mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synovial and Adipose Tissue Composition in Overweight/Obese Patients With Active Rheumatoid Arthritis Under JAK/STAT Inhibition
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Assessment of synovial- and adipose tissue-derived inflammatory biomarkers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety and Immunogenicity Study of SARS-CoV-2 Inactivated Vaccine
Status: COMPLETED
Conditions: SARS-CoV2 Infection
Interventions: BIOLOGICAL: SARS-CoV-2 vaccine (inactivated)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Investigational Scan (Ga-68 PSMA-11 PET/CT) for the Detection of Therapy Response in Patients With Metastatic Adenoid Cystic Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Metastatic Adenoid Cystic Carcinoma
Interventions: PROCEDURE: Computed Tomography|OTHER: Electronic Health Record Review|DRUG: Ga-68 PSMA-11|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Study Comparing Fluoroscopically-Guided Versus Blinded Trochanteric Bursa Injections
Status: COMPLETED
Conditions: Bursitis
Interventions: PROCEDURE: trochanteric bursa injection done under fluoroscopy with depomedrol and bupivacaine|PROCEDURE: Trochanteric bursa injection with depomedrol and bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Determine Imaging Parameters of LMI1195 in Heart Failure Patients at Low and High Risk of Defibrillator Firing
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: DRUG: LMI 1195
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Metabolic Effects of a Thermogenic Ready-to-drink Beverage
Status: COMPLETED
Conditions: Metabolic Rate|Metabolism
Interventions: OTHER: Thermogenic Ready-to-drink Beverage|OTHER: Placebo Ready-to-drink Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Intravitreal Bevacizumab on Early Post-Vitrectomy Hemorrhage in Diabetic Patients
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Muscle Energy Technique Versus Mulligan Technique for Treating Neck Pain in Breast Feeding Women
Status: UNKNOWN
Conditions: Neck Pain|Breast Feeding
Interventions: OTHER: Muscle Energy Technique|OTHER: Mulligan Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic and Pharmacodynamic Study of Phenoxymethylpenicillin for Children
Status: COMPLETED
Conditions: Phenoxymethylpenicillin
Interventions: DRUG: Phenoxymethylpenicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Pharmacokinetics and Pharmacodynamics of Insulin Lispro to Humalog® in Healthy Subjects
Status: COMPLETED
Conditions: Clamp Study
Interventions: DRUG: Insulin Lispro|DRUG: Humalog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: OPTImal PALliative Anti-epidermal Growth Factor Receptor Treatment in Metastatic Colorectal Cancer -
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic|Circulating Tumor DNA|KRAS Gene Mutation|NRAS Gene Mutation|BRAF Gene Mutation|Epidermal Growth Factor Receptor Inhibitor
Interventions: OTHER: Plasma circulating DNA analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ESWL Versus ESWL and Endoscopic Treatment
Status: UNKNOWN
Conditions: Pancreatitis
Interventions: PROCEDURE: extracorporeal shock wave lithotripsy|PROCEDURE: endoscopic drainage of the main pancreatic duct|DRUG: Analgesics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Risperidone (R064766) in Children and Adolescents With Irritability Associated With Autistic Disorder
Status: COMPLETED
Conditions: Autistic Disorder in Children and Adolescents
Interventions: DRUG: Risperidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of GX-70 in TB Patient
Status: WITHDRAWN
Conditions: Pulmonary Tuberculoses|High Risk Factors for Relapse|Treatment Failure
Interventions: DRUG: GX-70 by electroporation|DRUG: GX-70 by electroporation|DRUG: GX-70 by electroporation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Safety of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's Disease Currently Receiving Memantine
Status: WITHDRAWN
Conditions: Alzheimer's Disease|Dementia|Cognition
Interventions: DRUG: EVP-6124
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicentre Trial of Suboxone in Opiate-dependent Subjects in Taiwan
Status: COMPLETED
Conditions: Opiate Dependence
Interventions: DRUG: Buprenorphine + naloxone (Suboxone)|DRUG: Buprenorphine + naloxone (Suboxone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of BI 201335 Mediated UGT1A1 (Uridine-diphosphate-glucuronosyltransferases) Inhibition in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 201335 NA|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desflurane and Postoperative Sleep Quality in Patients Undergoing Elective Breast Surgery
Status: COMPLETED
Conditions: Desflurane|Propofol|Postoperative Sleep|PSQI|Breast Tumor
Interventions: DRUG: Desflurane Inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Nociception Guided by NoL Index and PK of Fentanyl in Pediatric Patients Under General Anesthesia
Status: COMPLETED
Conditions: Pain|Anesthesia|Pediatric ALL
Interventions: DRUG: Fentanyl|OTHER: Tetanic stimulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Administration of Fibrinogen in Polytraumatized Patients With Hypofibrinogenemia: a Randomized Feasibility Trial
Status: COMPLETED
Conditions: Trauma|Bleeding Disorder|Fibrinogen; Deficiency, Acquired
Interventions: DRUG: Fibrinogen concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate in Treating Patients With Fatigue Caused by Cancer
Status: COMPLETED
Conditions: Fatigue|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: methylphenidate hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel and Lansoprazole|DRUG: Clopidogrel and Dexlansoprazole|DRUG: Clopidogrel and Omeprazole|DRUG: Clopidogrel and Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: BEHAVIORAL: Performance of WHEELS-I in promoting DASH/SRD adoption|BEHAVIORAL: Effects of a 2-week DASH/SRD intervention vs. control diet on HFpEF functional cardiovascular risk factors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Status: RECRUITING
Conditions: Obesity, Morbid|Extubation Failure
Interventions: DEVICE: Noninvasive ventilation alternating with high flow nasal cannula|DEVICE: High flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy of SAGE-217 in the Treatment of Adult Participants With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: SAGE-217|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Pneumatic Compression to Improve Revascularization Outcome
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Intermittent pneumatic leg compressions|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Midlife Cholesterol Study
Status: COMPLETED
Conditions: Menopause|Postmenopause|Premenopause|Cardiovascular Disease
Interventions: DRUG: transdermal estradiol patch (Vivelle), oral estrogen (Estrace), progesterone (Prometrium)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Drug Interaction Study of LY3871801 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3871801|DRUG: Methotrexate|DRUG: Warfarin|DRUG: Dextromethorphan|DRUG: Midazolam|DRUG: Repaglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Effectiveness of Ozurdex Steroid Implants for DME After Vitrectomy Surgery
Status: TERMINATED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy
Status: ENROLLING_BY_INVITATION
Conditions: Epilepsy, Temporal Lobe
Interventions: DEVICE: LIFUP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure
Status: COMPLETED
Conditions: Renal Failure|Critical Care|Gram Positive Bacteria
Interventions: DRUG: Daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone
Status: COMPLETED
Conditions: Fibrous Dysplasia of Bone
Interventions: DRUG: risedronate|DRUG: placebo|DRUG: risedronate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Chemotherapy Using Focused Ultrasound for Liver Tumours
Status: COMPLETED
Conditions: Liver Tumour
Interventions: DRUG: ThermoDox® (LTLD)|DEVICE: Focused Ultrasound of Target Liver Tumour|DIAGNOSTIC_TEST: Pre-LTLD Biopsy of Target Liver Tumour|DIAGNOSTIC_TEST: Post-LTLD Biopsy of Target Liver Tumour|DIAGNOSTIC_TEST: Post-LTLD+FUS (Post-FUS) Biopsy of Target Liver Tumour|DEVICE: Thermometry of Target Tumour
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations in Fed and Fasting in Healthy, Postmenopausal Women
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bazedoxifene/conjugated estrogens combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A COHORT STUDY TO EVALUATE IMMUNOGENICITY FOR CHINESE CHILDREN AT THE TIME OF CLINICAL PNEUMONIA DIAGNOSIS
Status: COMPLETED
Conditions: Immunogenicity, Vaccine
Interventions: BIOLOGICAL: PCV13 PAC study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: ATG FRESENIUS (Anti-Lymphocyte-Globulin)|DRUG: ATG FRESENIUS (Anti-Lymphocyte-Globulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of UHAC62XX Tablets Compared With Capsules in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: UHAC 62 XX tablet|DRUG: UHAC 62 XX capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men
Status: UNKNOWN
Conditions: Healthy|Men|Male Contraception
Interventions: DRUG: Dimethandrolone-Undecanoate|DRUG: Levonorgestrel 0.03 MG|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Decision Aid for Parents of Infants With UPJO
Status: RECRUITING
Conditions: Ureteropelvic Junction Obstruction|Ureteropelvic Junction; Obstruction, Congenital
Interventions: BEHAVIORAL: Parent Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Apitegromab for the Treatment of Adults Who Are Overweight or Obese
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DRUG: Apitegromab|DRUG: Placebo|DRUG: Semaglutide|DRUG: Tirzepatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nofazinlimab (CS1003)+Lenvatinib|DRUG: Nofazinlimab (CS1003) Placebo+Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Pembrolizumab|RADIATION: Stereotactic Radiation Therapy|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Immunogenicity and Safety of Seqirus Quadrivalent Influenza Vaccine (QIV) in a Pediatric Population 6 Months Through 59 Months of Age.
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Seqirus Quadrivalent Inactivated Influenza Vaccine|BIOLOGICAL: Comparator Quadrivalent Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of TaiHao Breast Ultrasound Diagnosis Software RN-CES Descartes
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Diseases
Interventions: DIAGNOSTIC_TEST: Define Standard of Truth (SOT) by Taihao Breast Cancer Diagnostic Software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate Mirabegron in Pediatric Participants From 5 to Less Than 18 Years of Age With Overactive Bladder (OAB)
Status: TERMINATED
Conditions: Overactive Bladder (OAB)|Pharmacokinetics of Mirabegron
Interventions: DRUG: Mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of RR-HNK in OCD
Status: NOT_YET_RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: RR-HNK/Hydroxynorketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children
Status: COMPLETED
Conditions: Beta Thalassemia Major Anemia|Iron Overload
Interventions: DRUG: Deferiprone oral solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DEVICE: Platelet rich fibrine|DEVICE: Open Flap Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Safety Single-arm Study of CDK4/6 Inhibition With Palbociclib in Hospitalized, Moderate COVID-19 Cases to Prevent Thromboinflammation
Status: WITHDRAWN
Conditions: COVID-19
Interventions: DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adult Oxytocin Study
Status: COMPLETED
Conditions: Schizophrenia|Oxytocin|Social Cognition
Interventions: DRUG: Oxytocin|DRUG: Saline Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT