pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy Subjects
Status: COMPLETED
Conditions: Liver Diseases|Hepatic Encephalopathy|Hepatic Insufficiency
Interventions: DIETARY_SUPPLEMENT: Branched chain amino acids
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Immunotherapy or Targeted Therapy with or Without Stereotactic Radiosurgery for Patients with Brain Metastases from Melanoma or Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|Melanoma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening and Treating Asymptomatic Bacteriuria Every Trimester and Preterm Birth
Status: COMPLETED
Conditions: Preterm Birth|Asymptomatic Bacteriuria in Pregnancy
Interventions: COMBINATION_PRODUCT: Griess,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon Awakening
Status: COMPLETED
Conditions: Sleep Inertia|Caffeine|Placebo
Interventions: DIETARY_SUPPLEMENT: Caffeine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Antiviral Activity of BLD-2660 in COVID-19 Hospitalized Subjects
Status: COMPLETED
Conditions: Sars-CoV-2|Covid19
Interventions: DRUG: BLD-2660
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Serostim® Human Immunodeficiency Virus-Associated Adipose Redistribution Syndrome
Status: COMPLETED
Conditions: Human Immunodeficiency Virus-Associated Adipose Redistribution Syndrome
Interventions: BIOLOGICAL: Serostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of Minimally Invasive Approach In The Surgical Treatment Of Complex Perianal Fistula
Status: RECRUITING
Conditions: Fistula Perianal
Interventions: PROCEDURE: Minimally Invasive Approach In The Mucosal Advancement Flap Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detecting Lung Infections Through Vibration
Status: COMPLETED
Conditions: Lung Infection
Interventions: PROCEDURE: Group 1 will receive 15 Hz|PROCEDURE: Group 2 will receive 30 Hz|PROCEDURE: Group 3 will receive 60 Hz|PROCEDURE: Group 4 will receive 100 Hz|PROCEDURE: Phase II Optimal Frequency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of and Immune Response to an HIV Preventive Vaccine (HIV-1 Gag DNA Alone or With IL-15 DNA) Given With or Without 2 Different Booster Vaccinations in HIV Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIV-1 gag DNA|BIOLOGICAL: IL-15 DNA adjuvant|BIOLOGICAL: IL-12 DNA adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: LIVIA 2.0 : A RCT Of Two French Internet Intervention For Adults Struggling With Prolonged Grief Symptoms
Status: COMPLETED
Conditions: Prolonged Grief Disorder
Interventions: DEVICE: LIVIA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Cellulitis|Abscess|Drain Abscess|Impetigo|Skin Infection|Antibiotic Duration|Behavioral Economics
Interventions: BEHAVIORAL: Default Duration order Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparative Study of High Performance Low-Cost Optical Coherence Tomography
Status: SUSPENDED
Conditions: Optical Coherence Tomography of Retina
Interventions: DEVICE: retinal imaging with low-cost OCT device|DEVICE: retinal imaging with commercial OCT device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Implementation of a CDSS in Oncology Patients During COVID-19
Status: COMPLETED
Conditions: Breast Cancer|Obesity|Cardiovascular Disease Other
Interventions: OTHER: Application of CDSS to provide nutritional care in breast cancer patients from home|OTHER: General lifestyle advice to breast cancer patients by phone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Transcatheter Aortic Valve Replacement|Intracranial Embolism
Interventions: DRUG: Preloading before TAVI|DRUG: Postloading after TAVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety of MRI Scans in People Who Have Breast Tissue Expanders After Mastectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Breast Neoplasms|Breast Adenocarcinoma
Interventions: DIAGNOSTIC_TEST: MRI Studies|BEHAVIORAL: Patient Reported Outcomes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Hyperbaric Bupivacaine With Fentanyl vs. Hyperbaric Bupivacaine With Dexmedetomidine in Reducing Visceral Pain During Cesarean Delivery Under Spinal Anaesthesia
Status: NOT_YET_RECRUITING
Conditions: Visceral Pain
Interventions: DRUG: Intrathecal Bupivacaine-Fentanyl and Bupivacaine-Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Dialysate Sodium in Chronic Hospitalized Hemodialysis Patients
Status: COMPLETED
Conditions: Intra-dialytic Hypotension
Interventions: DRUG: Lower dialysate sodium (138 mmol/L; using Renasol hemodialysis concentrate)|DRUG: Higher dialysate sodium (142 mmol/L; using Renasol hemodialysis concentrate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy With Single-Agent Cisplatin or Combination Chemotherapy in Defined Poor-Prognostic Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: Gemzar (gemcitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ENHANCE: Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA)
Status: COMPLETED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: seladelpar 5-10 mg|DRUG: seladelpar 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer
Status: TERMINATED
Conditions: Oral Cavity Squamous Cell Carcinoma
Interventions: DEVICE: Computed Tomography|DEVICE: Positron Emission Tomography and Computed Tomography Scan|DEVICE: Cone-Beam Computed Tomography|DEVICE: Magnetic Resonance Imaging|PROCEDURE: Therapeutic Conventional Surgery|PROCEDURE: Histopathologic Examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: AdCh63 ME-TRAP|BIOLOGICAL: MVA ME-TRAP|OTHER: Sporozoite challenge|BIOLOGICAL: Mixture of AdCh63 ME-TRAP and MVA ME-TRAP intramuscularly
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication|Critical Illness
Interventions: DRUG: ceftriaxone|DRUG: ciprofloxacin|DRUG: imipenem|DRUG: linezolid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Topical Prostaglandins on the Biomechanical Properties of the Cornea in Patients With Open Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DRUG: topical prostaglandin analogs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erbium Chromium: YSGG Laser Effect on Surgical Treatment of Chronic Periodontitis
Status: COMPLETED
Conditions: Generalized Chronic Periodontitis
Interventions: DEVICE: laser device Er,Cr:YSGG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Bioavailability of Rocatinlimab (AMG 451) Vial and Prefilled Syringe in Healthy Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Rocatinlimab vial injection|COMBINATION_PRODUCT: Rocatinlimab prefilled syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel/Carboplatin Plus Bevacizumab/Erlotinib in the First Line Treatment of Carcinoma of Unknown Primary Site
Status: COMPLETED
Conditions: Neoplasm, Unknown Primary
Interventions: DRUG: paclitaxel|DRUG: carboplatin|DRUG: bevacizumab|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feru-guard for Behavioral Symptoms in Dementia
Status: UNKNOWN
Conditions: Behavioral and Psychiatric Symptoms of Dementia
Interventions: DRUG: Feru-guard 100M|OTHER: Feru-guard 100M Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Protease Inhibitor Regimen Switch in HIV-1 Infected Patients With Undetectable Viral Load to Prove the Non-inferiority of Once Daily Dose Regimen Versus the Current Twice Daily Regimen to Maintain the Viral Load Under the Limit of Detection.
Status: COMPLETED
Conditions: HIV-1 Infection|HIV Infections
Interventions: DRUG: darunavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Tremelimumab in Treating Patients With Recurrent Stage IV Lung Cancer
Status: COMPLETED
Conditions: Recurrent Squamous Cell Lung Carcinoma|Stage IV Squamous Cell Lung Carcinoma AJCC v7
Interventions: BIOLOGICAL: Durvalumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Regional Anesthesia for Septic Limb Orthopedic Surgery
Status: UNKNOWN
Conditions: Osteo Arthritis|Cellulitis
Interventions: DRUG: Systemic analgesia + Continuous regional anesthesia|DRUG: Systemic analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fructose in Exercising Individuals With Type 1 Diabetes Using Insulin Degludec
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Diabetes Complications
Interventions: DIETARY_SUPPLEMENT: Fructose|OTHER: Plain water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study Between Posterior Lumbar Interbody Fusion(PLIF) and Intertransverse Process Fusion in Treatment of Spodylolithesis
Status: UNKNOWN
Conditions: Lumbar Spondylolisthesis
Interventions: PROCEDURE: Posterior lumbar interbody fusion|PROCEDURE: Inter transverse bone grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using a Systematic Review in Clinical Decision Making: a Pilot Parallel, Randomized Controlled Trial
Status: COMPLETED
Conditions: Evidence-Based Medicine
Interventions: OTHER: Shortened Format|OTHER: Full Length
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhalation to Improve Host Defense and Pulmonary Barrier Restoration
Status: COMPLETED
Conditions: ARDS
Interventions: DRUG: inhaled molgramostim (rhGM-CSF)|DRUG: inhaled placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Cooling Device for the Elimination of Warm Ischemia During Renal Transplantation
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplant; Complications|Delayed Graft Function
Interventions: DEVICE: Kidney cooling device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Displaced Proximal Humeral Fractures: Delta Prothesis or Philos Plate?
Status: COMPLETED
Conditions: Proximal Humeral Fractures, AO/OTA (2007) Group B2 and C2
Interventions: DEVICE: Reverse total shoulder arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Adebrelimab Combined With Famitinib and Chemotherapy in the Treatment of ES-SCLC.
Status: NOT_YET_RECRUITING
Conditions: Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: adebrelimab|DRUG: famitinib|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Prenatal DHA Supplements on Infant Development
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: DHA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Relative Bioavailability of Entrectinib Capsule Formulations F1 and F06 Under Fed Conditions in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Entrectinib Test Formulation (F1)|DRUG: Entrectinib Reference Formulation (F06)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant Followed By Donor White Blood Cell Infusions in Treating Young Patients With Hematologic Cancer
Status: TERMINATED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: filgrastim|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: melphalan|DRUG: methotrexate|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Ocular Blood Flow Effects of Unoprostone Isopropyl in Adults With Dry Age-related Macular Degeneration
Status: COMPLETED
Conditions: Dry Age-related Macular Degeneration
Interventions: DRUG: unoprostone isopropyl|DRUG: unoprostone isopropyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How Useful is the Advice: "Fill up a Handful of Sunscreen and Spread it All Over Your Body"
Status: COMPLETED
Conditions: Quantity of Sunscreen|Sun Protection Factor|Sun Safety Campaigns|Sunscreen Use
Interventions: BEHAVIORAL: Fill up a handful of sunscreen and spread it all over your body. Sunscreen, Actinica
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock
Interventions: DRUG: AZD9773|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, TAK-915-1001, Single-Rising Dose, Multiple-Rising Dose, Drug-Drug Interaction, Relative Bioavailability, Food Effect, and Effect on Elderly Participants Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-915 suspension|DRUG: Midazolam|DRUG: Placebo|DRUG: TAK-915 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Losartan or Eprosartan on Fructose Hyperuricemia
Status: COMPLETED
Conditions: Uric Acid Concentration, Serum, Quantitative Trait Locus 7
Interventions: DRUG: losartan and eprosartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction
Status: RECRUITING
Conditions: Cardiotoxicity|HER2-positive Breast Cancer|Heart Failure|Cancer, Therapy-Related
Interventions: OTHER: Phased withdrawal of heart failure medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant Depression
Status: WITHDRAWN
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Esketamine 28 mg|DRUG: Esketamine 56 mg|DRUG: Esketamine 84 mg|DRUG: Placebo|DRUG: Escitalopram|DRUG: Sertraline|DRUG: Duloxetine|DRUG: Mirtazapine|DRUG: Agomelatine|DRUG: Bupropion|DRUG: Trazodone Prolonged Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Versus Endovascular Repair of Popliteal Artery Aneurysm Trial
Status: TERMINATED
Conditions: Popliteal Artery Aneurysm
Interventions: PROCEDURE: Open repair of popliteal artery|PROCEDURE: Endovascular repair of popliteal artery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 'TOTAL' (Tracheal Occlusion To Accelerate Lung Growth) Trial
Status: COMPLETED
Conditions: Hernia|Hernia, Diaphragmatic|Hernia, DIaphragmatic, Congenital|Pathological Conditions, Anatomical|Congenital Abnormalities|Congenital Diaphragmatic Hernia|Fetal Anomaly|Fetal Surgery|Pulmonary Hypoplasia
Interventions: DEVICE: GoldBal2 detachable balloon|DEVICE: Baltaccidbpe100 Delivery Catheter|OTHER: Standardized postnatal care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comitial Prophylaxis in Neurosurgery in Patients Who Have Undergone Intracranial Surgery Programmed Supratentorial Surgery (Exeresis or Biopsy) Between 2019 and 2022
Status: ACTIVE_NOT_RECRUITING
Conditions: Anti-epileptic Prophylaxis in Intracranial Neurosurgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Long-term Effects Secondary to Cancer Therapy in Children
Interventions: RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine
Status: RECRUITING
Conditions: Long COVID|Post COVID Condition|Post Acute Sequelae of COVID-19
Interventions: DRUG: Ibudilast|DRUG: Pentoxifylline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Levothyroxine Post Radioactive Iodine
Status: COMPLETED
Conditions: Graves' Disease
Interventions: DRUG: Levothyroxine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Doxorubicin HCL Liposome Injection (DOXIL) in Combination With Abraxane in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: DOXIL|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Education During Waiting Time of Vaccination on the Knowledge Towards COVID-19 Among Chinese Residents
Status: UNKNOWN
Conditions: Covid19|Knowledge, Attitudes, Practice
Interventions: OTHER: Read leaflets containing knowledge of COVID-19 and vaccination.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Impact of Chronic Kidney Disease on the Effects of Ticagrelor in Patients With Diabetes and Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: DRUG: ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Locally Advanced Head and Neck Carcinoma
Interventions: DRUG: Gabapentin|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab and Peripheral Scatter Laser in Patients With Diabetic Macular Edema and Peripheral Nonperfusion
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: intravitreal injection of ranibizumab|PROCEDURE: peripheral laser|DRUG: intravitreal injection of triamcinolone acetonide|PROCEDURE: macular laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adherence to ASV Therapy in Heart Failure With Preserved Ejection Fraction Feasibility Study
Status: TERMINATED
Conditions: Heart Failure With Normal Ejection Fraction|Sleep Apnea
Interventions: DEVICE: ASV Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dermacyd PH_DETINBACK Tangerine Mix (Lactic Acid)- Compatibility
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: Lactic Acid (Dermacyd PH_DETINBACK Tangerine Mix)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Status: COMPLETED
Conditions: Diabetic Retinopathy|Retinal Vein Occlusion|Retinal Artery Occlusion|Central Serous Chorioretinopathy|Pathologic Myopia|Retinitis Pigmentosa|Epiretinal Membrane|Macular Holes|Nonexudative Age-related Macular Degeneration|Exudative Age Related Macular Degeneration|Suspect Glaucoma|Optic Atrophy|Retinal Detachment
Interventions: DIAGNOSTIC_TEST: Software assisted imaging diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise
Status: COMPLETED
Conditions: Insulin Resistance and Type 2 Diabetes
Interventions: BEHAVIORAL: Weight loss - diet only|BEHAVIORAL: Weight loss plus exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Betaine, Exercise Performance, and Gut Permeability
Status: RECRUITING
Conditions: Metabolic Disturbance|Permeability; Increased
Interventions: DIETARY_SUPPLEMENT: Betaine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autologous Stem Cells for Spinal Cord Injury (SCI) in Children
Status: TERMINATED
Conditions: Spinal Cord Injury
Interventions: BIOLOGICAL: bone marrow progenitor cells (BMPC) autologous transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacubitril-valsartan and Heart Failure Patients : the ENTRESTO-SAS Study
Status: COMPLETED
Conditions: Chronic Heart Failure|Sleep Apnea Syndrome
Interventions: DRUG: SACUBITRIL - VALSARTAN (formerly LCZ696, ENTRESTO®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies.
Status: COMPLETED
Conditions: Herpes Genitalis
Interventions: DRUG: Valaciclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anterior Thoracic Perforating Artery (PATA); Systematization and Applications in Reconstructive Surgery of the Head and Neck
Status: RECRUITING
Conditions: Upper Aero-intestinal Tract Cancer|Supraclavicular Flap|Anterior Thoracic Perforator Artery
Interventions: PROCEDURE: Doppler ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of a Fiber-enriched Bakery Product on Glucose, Insulin Values and Appetite
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Enriched panettone|OTHER: Panettone standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome|Aggression|Self-Injurious Behavior|Pathologic Processes|Behavioral Symptoms|Intellectual Disability|Neurobehavioral Manifestations|Neurologic Manifestations|Nervous System Diseases|Abnormalities, Multiple|Congenital Abnormalities|Chromosome Disorders|Genetic Diseases, Inborn|Obesity|Overnutrition|Nutrition Disorders|Antihypertensive Agents|Neurotransmitter Agents|Molecular Mechanisms of Pharmacological Action|Physiological Effects of Drugs|Skin-Picking
Interventions: DRUG: Guanfacine Extended Release|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aldosterone and Glucose Homeostasis
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Aldosterone infusion (A)|DRUG: Vehicle Infusion (V)|OTHER: High Sodium Diet (HS)|OTHER: Low Sodium Diet (LS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Biphasic Insulin Aspart 30 Twice Daily With Two Different Initial Dosage Split Regimens in Subjects With Type 2 Diabetes: An Extension to Trial BIASP-3756
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 30|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fetal Endotracheal Occlusion (FETO) in Severe and Extremely Severe Congenital Diaphragmatic Hernia
Status: COMPLETED
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: Goldballoon Detachable Balloon and delivery microcatheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: An Open Label Single-arm Phase 4 Study of Vedolizumab in Subjects With Newly Diagnosed Active Ulcerative Colitis
Status: WITHDRAWN
Conditions: Ulcerative Colitis
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers
Status: COMPLETED
Conditions: Metastatic Malignant Neoplasm in the Bone|Metastatic Malignant Neoplasm in the Lung|Salivary Gland Carcinoma|Stage IV Major Salivary Gland Cancer AJCC v8|Stage IVA Major Salivary Gland Cancer AJCC v8|Stage IVB Major Salivary Gland Cancer AJCC v8|Stage IVC Major Salivary Gland Cancer AJCC v8
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Korean Botulinum Toxin Type A Versus Botox in the Treatment of Essential Blepharospasm
Status: COMPLETED
Conditions: Blepharospasm
Interventions: DRUG: Korean Botulinum toxin type A (KbtxA) and Botox injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Tolerability, Pharmacokinetic Characteristics of PA1010 in Healthy Subjects
Status: COMPLETED
Conditions: Chronic HBV Infection
Interventions: DRUG: PA1010
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Factors of Graft Detachment Following Dmek
Status: COMPLETED
Conditions: Fuchs' Endothelial Corneal Dystrophy|Descemet Membrane Endothelial Keratoplasty|Pseudophakic Bullous Keratopathy|Graft Detachment
Interventions: PROCEDURE: Descemet Membrane Endothelial Keratoplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigating the Acute Effects of Flavonoids in Blueberries on Cognitive Function.
Status: COMPLETED
Conditions: Healthy Adults.
Interventions: DIETARY_SUPPLEMENT: Flavonoids|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Chitosan Chewing Gum in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: K2CG chewing gum (20mg chitosan)|OTHER: K2CG chewing gum (60mg chitosan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Simulation Trial of Telemedical Support for Paramedics
Status: NOT_YET_RECRUITING
Conditions: Emergencies|Cardiopulmonary Arrest|Acute Respiratory Failure|Status Epilepticus
Interventions: OTHER: Video teleconsultation|OTHER: Audio support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study of a Breast Cancer Vaccine Plus Poly-ICLC for Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: poly-ICLC|BIOLOGICAL: 9 Peptides from Her-2/neu, CEA, & CTA|BIOLOGICAL: Peptide-tet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Oligo-Fucoidan in Advanced Hepatocellular Carcinoma (HCC)
Status: SUSPENDED
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DIETARY_SUPPLEMENT: Oligo Fucoidan|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sevoflurane, Propofol and Desflurane on POD/POCD
Status: UNKNOWN
Conditions: Sevoflurane|Propofol|Desflurane
Interventions: DRUG: Sevoflurane|DRUG: Propofol|DRUG: Desflurane
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of BMS-354825 (Dasatinib) in Patients With Chronic Myeloid Leukemia Who Are Either Resistant or Intolerant to Imatinib
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia|Philadelphia-Positive Myeloid Leukemia
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Kefir Beverage on Immunity and Lipid Profile
Status: COMPLETED
Conditions: Prebiotics
Interventions: DIETARY_SUPPLEMENT: Prebiotic group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Salt Intake, Hydration Status and Gastrointestinal Discomfort During Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Salt 3 g|OTHER: Salt 6 g|OTHER: Salt 9 g
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Sleepio After Cancer Study
Status: NOT_YET_RECRUITING
Conditions: Insomnia|Cancer
Interventions: OTHER: Digital Cognitive Behavioural Therapy for Insomnia (dCBT-I)|OTHER: Sleep Hygiene Education (SHE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PuraStat for the Prevention of Delayed Bleeding After Endoscopic Resection of Colorectal Lesions
Status: UNKNOWN
Conditions: Bleeding After Resection of Colorectal Neoplastic Lesions
Interventions: DEVICE: Interventional arm: endoscopic resection plus PuraStat®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Swaddling on Infants During Feeding
Status: COMPLETED
Conditions: Premature Birth
Interventions: BEHAVIORAL: Swaddling Intervention for Preterm Infants|BEHAVIORAL: Unswaddled Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft.
Status: RECRUITING
Conditions: Degenerative Disc Disease|Spondylolisthesis
Interventions: DEVICE: NanoBone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide
Status: COMPLETED
Conditions: Newly Diagnosed High-Grade Glioma
Interventions: DRUG: Mebendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Facilitation of Extinction Retention and Reconsolidation Blockade in PTSD
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: 3-day differential fear conditioning, extinction, and extinction retention testing paradigm|DRUG: Allopregnanolone (Allo) with Dexolve in 0.9% saline for injection manufactured by University of California, Davis|OTHER: Matching IV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gemcitabine and Pazopanib in Chemotherapy Naïve Patients With Advanced/Metastatic Urothelial Carcinoma Ineligible for Cisplatin-based Chemotherapy
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Gemcitabine|DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthrocentesis Versus Operative Arthroscopy Treatment of TMJ Internal Derangement (TMJ)
Status: COMPLETED
Conditions: Temporomandibular Joint Disc Displacement|Temporomandibular Joint Disorders
Interventions: PROCEDURE: arthrocentesis|PROCEDURE: operative arthroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Metformin on Self-selected Exercise Intensity, Physical Fitness and Exercise-induced AMPK-activation
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Trial of rhTPO Versus Placebo for Low/Intermediate-1 Risk MDS With Thrombocytopenia
Status: UNKNOWN
Conditions: Low/Intermediate Risk-1 MDS
Interventions: DRUG: Danazol + rhTPO (recombinant human thrombopoietin injection)|DRUG: Danazol + sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Youth Metacognitive Therapy Feasibility Trial
Status: COMPLETED
Conditions: Child Mental Disorder|Anxiety Disorders|Depression
Interventions: BEHAVIORAL: Treatment as usual: Control|BEHAVIORAL: Group Metacognitive Therapy (Group-MCT): Experimental
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Cisplatin + Temozolomide in Malignant Glial Tumours in Children and Adolescents
Status: COMPLETED
Conditions: Glioma
Interventions: DRUG: Temozolomide, Cisplatinum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine|DRUG: Saline|DRUG: Acetaminophen|DRUG: Ibuprofen 400Mg Tablet / Celebra 100 Mg tablet|DEVICE: ultrasound-guided nerve block|DRUG: Morphine|DEVICE: Patient-controlled analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of P-3073 Nail Solution in the Treatment of Nails Affected by Psoriasis
Status: COMPLETED
Conditions: Nail Psoriasis
Interventions: DRUG: P-3073|DRUG: Vehicle of P-3073
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of Glycemic Index and Glycemic Load of Cereal Fiber Powder
Status: COMPLETED
Conditions: Glycemic Index
Interventions: DIETARY_SUPPLEMENT: Cereal powder|DIETARY_SUPPLEMENT: Pure glucose powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Medication Reviews in Severe Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Diabetes|Metabolic Syndrome|Severe Mental Disorder|Major Depressive Disorder|Bipolar Disorder|Psychosis|Psychotic Disorders
Interventions: OTHER: medication review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects
Status: COMPLETED
Conditions: Heart Failure|Type II; Diabetes
Interventions: DRUG: Empagliflozin|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism|Chronic Kidney Disease-Mineral and Bone Disorder|Dialysis|Hypocalcemia|Hypoparathyroidism
Interventions: DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing, a Mobile Health Application for HIV Infected and Uninfected Women With Co-morbidities in the Outpatient Setting
Status: COMPLETED
Conditions: Mobile Health|Asthma|Diabetes Mellitus
Interventions: BEHAVIORAL: Use mobile health app (WellXcel) to increase knowledge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Joint Awareness Between Fixed-bearing and Mobile-bearing Total Knee Arthroplasty Using Titanium-nitride Coated Posterior-stabilized Prostheses
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Arthropathy of Knee|Joint Awareness
Interventions: DEVICE: Fixed-bearing TKA|DEVICE: Mobile-bearing TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of LY2189265 on Insulin Secretion in Response to Intravenous Glucose
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BIOLOGICAL: LY2189265|DRUG: Placebo|DRUG: Insulin|DRUG: Glucose|DRUG: Glucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine to Prevent Agitation After Free Flap Surgery
Status: COMPLETED
Conditions: Agitation|Delirium
Interventions: DRUG: Dexmedetomidine|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Furosemide Versus Vascular Filling in Patients With Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Acute Myocardial Infarction With Right Ventricular Extension
Interventions: DRUG: Furosemide|DRUG: Placebo filling|DRUG: Placebo furosemide|DRUG: Vascular filling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Hydralazine and Valproic Acid in Advanced Solid Tumor Malignancies
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Hydralazine and Valproic Acid: Cohort -1|DRUG: Hydralazine and Valproic Acid: Cohort 0|DRUG: Hydralazine and Valproic Acid: Cohort 1|DRUG: Hydralazine and Valproic Acid: Cohort 2|DRUG: Hydralazine and Valproic Acid: Cohort 3|DRUG: Hydralazine and Valproic Acid: Cohort 4|DRUG: Hydralazine and Valproic Acid: Cohort 5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orelabrutinib,Rituximab and Methotrexate in Newly Diagnosed Primary Central Nervous System Lymphoma
Status: RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: Orelabrutinib|DRUG: Rituximab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Clinical Trial of Teriparatide in Japan
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Omicron Variant-Matched Vaccine Booster in Adults
Status: COMPLETED
Conditions: COVID-19 Pandemic|Immunogenicity|SARS CoV 2 Infection|COVID-19
Interventions: BIOLOGICAL: mRNA-1273.214 Vaccine|BIOLOGICAL: MRNA-1273 Vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: MRNA-1273.222 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Nelarabine in Patients With Relapsed/Refractory Lymphoid Malignancies
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Nelarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT