pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Status: RECRUITING
Conditions: PreDiabetes|Insulin Resistance|Overweight|Obesity
Interventions: DIETARY_SUPPLEMENT: Palmitoleic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Lateral Ridge Augmentation Using Cross-linked or Non-cross-linked Collagen Membrane
Status: COMPLETED
Conditions: Bone Loss
Interventions: OTHER: non-cross-linked porcine skin collagen membrane|OTHER: glutaraldehyde cross-linked bovine collagen membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Long-term Safety Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease Who Have Completed a Previous AT1001 Study
Status: TERMINATED
Conditions: Fabry Disease
Interventions: DRUG: migalastat HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Determine the Safety, Tolerability and Effect of RLS-0071 Doses When Given to Healthy Adults After Inhaling LPS
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RLS-0071 (10 mg/kg intravenously every 8 hours for total of 3 doses)|DRUG: RLS-0071 (loading dose of 120 mg/kg followed by 40 mg/kg every 8 hours for 2 additional doses)|DRUG: Placebo (saline dosed every 8 hours for a total of 3 doses)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Novel Reamer-Irrigator-Aspirator on the Incidence of Fat Embolism
Status: COMPLETED
Conditions: Embolism|Femoral Fractures
Interventions: DEVICE: Reamer Irrigator Aspirator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acute Renal Injury After Major Elective Non-Cardiac Surgery
Status: COMPLETED
Conditions: Acute Renal Injury
Interventions: DRUG: Crystalloid Solutions|DRUG: Colloid Blood Volume Expanders|OTHER: blood replacement|DRUG: Diuretic|DRUG: noradrenaline|DRUG: Non-Steroidal Anti-Inflammatory Analgesics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of HRS9531 Injection in Obese Subjects With Obstructive Sleep Apnea
Status: NOT_YET_RECRUITING
Conditions: Weight Management
Interventions: DRUG: HRS9531 Injection|DRUG: HRS9531 Injection|DRUG: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Homecare Integral Support Program for IPF Patients
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: COMBINATION_PRODUCT: Comprehensive patient support program (educational, physiotherapy, nutritional, emotional)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ispinesib In Combination With Capecitabine In Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor Cancer
Interventions: DRUG: Ispinesib|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Punctal Plugs on Ocular Surface After Povidone-Iodine Preparation of Intravitreal Injection
Status: COMPLETED
Conditions: Dry Eye Syndromes|Dry Eye|Ocular Surface Disease
Interventions: DEVICE: Punctal plug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ureteric Visualization: Vitamin B Vs 5% Dextrose in Water
Status: COMPLETED
Conditions: Pelvic Floor Disorders|Ureter; Kink
Interventions: OTHER: Vitamin B (riboflavin, vitamin B2)|OTHER: 5% Dextrose in Water (D5W)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Forteo Alendronate Comparator Trial
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Alendronate|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Vitamin D|DRUG: Placebo-Oral|DRUG: Placebo-SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acute Statin Treatment in Patients Undergoing Percutaneous Coronary Intervention
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Agitation Control With Ketamine in the Emergency Department
Status: COMPLETED
Conditions: Violent Aggressive Behavior|Ketamine
Interventions: DRUG: Ketalar|DRUG: Midazolam injection|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methylprednisolone vs. Dexamethasone in COVID-19 Pneumonia (MEDEAS RCT)
Status: COMPLETED
Conditions: Covid19|Viral Pneumonia Human Coronavirus|Severe Acute Respiratory Syndrome
Interventions: DRUG: Methylprednisolone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SFIB vs Anterior QLB in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Ultrasound Guided Suprainguinal Fascia iliaca Block|PROCEDURE: Ultrasound Guided Anterior Quadratus Lumborum Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Labour Analgesia; Comparing a Combinations of Either Fentanyl or Bupivacaine With Intrathecal Morphine
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Intrathecal morphine with fentanyl|DRUG: Intrathecal morphine with bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Distal and Proximal Muscle Fatigue for Healthy Young Adults
Status: NOT_YET_RECRUITING
Conditions: Healthy|Young Adult|Fatigue
Interventions: OTHER: Distal Muscle Fatigue Protocol|OTHER: Proximal Muscle Fatigue Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Teach-back Method on Patient Satisfaction and Adherence to Wound Care Regimen
Status: RECRUITING
Conditions: Keratinocyte Carcinoma
Interventions: BEHAVIORAL: SOC education|BEHAVIORAL: Ask-tell-ask education|OTHER: Participant satisfaction survey|OTHER: Wound care adherence survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hemodynamic Effects of Cold Versus Warm Fluid Bolus
Status: COMPLETED
Conditions: Temperature Change, Body|Hypovolemia
Interventions: DRUG: Ringer's Acetate (warm)|DRUG: Ringer's Acetate (cold)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Combination of Anti-PD-1 AK105 and Anlotinib in First-line Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: AK105|DRUG: Anlotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of the Sensory Test Using the Laryngopharyngeal Endoscopic Esthesiometer in Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive|Larynx|Sensory Disorder
Interventions: OTHER: Laryngopharyngeal sensory test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Novel Mechanisms and Predictors of VEGF Receptor Inhibitor- or Immune Checkpoint Inhibitor-Associated Hypertension and Cardiovascular Disease
Status: TERMINATED
Conditions: Renal Cell Carcinoma|Hypertension|Melanoma|Cancer
Interventions: DIAGNOSTIC_TEST: Ambulatory Blood Pressure Measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections
Status: RECRUITING
Conditions: Glioblastoma
Interventions: PROCEDURE: Awake mapping under local anesthesia|PROCEDURE: Asleep mapping under general anesthesia|PROCEDURE: Resection under general anesthesia without mapping
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Safety, Tolerability, PK & PD Study of AD-214 Administered to Healthy Volunteers
Status: COMPLETED
Conditions: Interstitial Lung Disease
Interventions: BIOLOGICAL: AD-214|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myocet Plus Endoxan for Older Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Liposomal-encapsulated doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose of 10 mg Immediate Release Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight
Status: TERMINATED
Conditions: Pharmacology, Clinical
Interventions: DRUG: Neladenoson bialanate (BAY 1067197)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exercise Intervention During Chemotherapy in Advanced Lung Cancer Patients
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Non Small Cell Lung Cancer Stage IIIB|Non Small Cell Lung Cancer Metastatic
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Three Types of Dressings After Hip Surgery
Status: COMPLETED
Conditions: Tape Blisters|Hip Surgery
Interventions: DEVICE: Dressing of wound|DEVICE: Dressing of wound|DEVICE: Dressing of wound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Real-Time Optical Biopsy in Improving Lung Cancer Diagnosis in Patients Undergoing Lung Biopsy
Status: SUSPENDED
Conditions: Lesion|Lung Cancer|Diagnoses Disease
Interventions: PROCEDURE: Biopsy|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ticagrelor in Clopidogrel Resistant Patients Undergoing Chronic Hemodialysis
Status: COMPLETED
Conditions: Platelet Reactivity
Interventions: DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Etanercept Plus Methotrexate to Either Etanercept or Methotrexate Alone in Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Active Rheumatoid Arthritis
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline
Status: RECRUITING
Conditions: Early Syphilis
Interventions: DRUG: Doxycycline|DRUG: Ceftriaxone|DRUG: benzathine penicillin G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Heating on Thermal Comfort and Anxiety
Status: COMPLETED
Conditions: Anxiety|Nurse-Patient Relations
Interventions: DEVICE: Bair Paws Blanket 81003 and FOC device 87500|OTHER: routine hospital care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Controlling Environmental Risk Factors in Established RA
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Management of risk factors|BEHAVIORAL: Smoking cessation|BEHAVIORAL: weightloss|OTHER: periodontal disease treatment|BEHAVIORAL: increased physical activity|BEHAVIORAL: Decreased anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Depression in Spouses of People With Cognitive Impairment
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: PST-MCI/AD Caregiving|BEHAVIORAL: NT-MCI/AD Caregiving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation and Assesment of Ginigivitis Patients Treated by Yarrow Natural Extract in Compare to a Contro Group
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Yarrow and moringa mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Low-dose PCI vs Durvalumab and Observation in Radically Treated Patients With Stage III NSCLC (NVALT28)
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Durvalumab|RADIATION: low-dose PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of the Blood-stage Malaria Candidate Vaccines RH5.1 in Matrix-M and R78C in Matrix-M in Healthy UK Adults
Status: RECRUITING
Conditions: Malaria, Falciparum
Interventions: BIOLOGICAL: Matrix M with R78C and/or RH5.1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of an Physician-Nurse Supplementary Triage Assistance Team on Emergency Department Patient Wait Times
Status: COMPLETED
Conditions: Emergencies
Interventions: BEHAVIORAL: Interaction with MDRN STAT|BEHAVIORAL: No MDRNSTAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Techniques for Tracheal Tube Exchange in Standard and Critical Care Patients
Status: COMPLETED
Conditions: Airway Morbidity
Interventions: DEVICE: Prone Position|DEVICE: Laryngeal tube|DEVICE: Endotracheal tube Leackage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Human Immunodeficiency Virus 1 (HIV-1) Participants Treated With Antiretroviral (ARV) Combination Therapy Including Raltegravir (MK-0518-138)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Raltegravir|DRUG: ARV (non-raltegravir)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of Yimitasvir Phosphate Capsule in Subjects With Normal Renal Function and ESRD
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Yimitasvir Phosphate Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Actiste® Diabetes Management as a Service (ADMS) Clinical Investigation
Status: COMPLETED
Conditions: Diabetes type1|Diabetes type2
Interventions: DEVICE: Device: Actiste 1.0 and the Companion app with TBL Backend
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
Status: RECRUITING
Conditions: Spinocerebellar Ataxia Type 1|Spinocerebellar Ataxia Type 2|Spinocerebellar Ataxia Type 3|Spinocerebellar Ataxia Type 6
Interventions: GENETIC: All Participants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Effect of Genetic Polymorphisms in ERCC1 and OCT2 on the Occurrence and Severity of Cisplatin-induced Nephrotoxicity
Status: UNKNOWN
Conditions: Cisplatin Adverse Reaction
Interventions: GENETIC: ERCC1|GENETIC: OCT2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Avastin (Bevacizumab) and Oxaliplatin Plus Xeloda (Capecitabine) in Patients With Advanced Colorectal Cancer.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: capecitabine [Xeloda]|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Eradication With a New Sequential Treatment
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Non Ulcer Dyspepsia|Duodenal Ulcer|Gastric Ulcer|Chronic Active Gastritis|Gastritis
Interventions: DRUG: Sequential therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Cloths to Reduce Surgical Site Infection in Cesarean Deliveries
Status: WITHDRAWN
Conditions: Surgical Site Infection
Interventions: DEVICE: Chlorhexidine Cloth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Whether Transperineal Prostate Biopsy Under Local-anaesthesia Using a Transperineal-access System is Non-inferior to Standard Transrectal Biopsy to Detect Prostate Cancer in Biopsy-naïve Men
Status: UNKNOWN
Conditions: Prostate Cancer|Prostatic Hyperplasia
Interventions: PROCEDURE: Prostate Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Large Simple Trial (LST) Of Cardiovascular Safety Of Ziprasidone And Olanzapine- (Zodiac)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Ziprasidone|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Intervention on Improving Midlife Women's Menopause-related Symptoms
Status: COMPLETED
Conditions: Genitourinary Symptoms
Interventions: BEHAVIORAL: Pelvic floor muscles training (PFMT) combined with yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
Status: COMPLETED
Conditions: Child|Anesthesia Morbidity|Delirium on Emergence
Interventions: DRUG: Midazolam 0.03mg/kg|DRUG: Midazolam 0.05mg/kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas
Status: NOT_YET_RECRUITING
Conditions: Neurofibromatosis 1|Plexiform Neurofibroma
Interventions: DRUG: Cabozantinib Oral Tablet|DRUG: Selumetinib Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Oxford AstraZeneca Vaccine Against COVID-19 Infection
Status: COMPLETED
Conditions: Vaccine Adverse Reaction|Seroconversion
Interventions: BIOLOGICAL: SARS-Cov-2 neutralizing antibody titer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Prednisone Combined With Huaiqihuang Granule for Primary Nephrotic Syndrome in Children
Status: RECRUITING
Conditions: Nephrotic Syndrome in Children
Interventions: DRUG: Huaiqihuang granule|DRUG: Prednisone|DRUG: Levamisole placebo|DRUG: Levamisole|DRUG: Huaiqihuang Granule placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Entecavir in Treatment-Naive Patients With HBeAg-Positive Chronic Hepatitis B.
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Entecavir|DRUG: peginterferon alfa-2a [Pegasys]|DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of the Combination of Post-transplant High Dose Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Acute Graft-versus-Host Disease in Patients Eligible to Allogeneic Hematopoietic Stem Cell Transplant
Status: UNKNOWN
Conditions: Hematological Malignancies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Invasive Versus Non-invasive Assessment of Blood Pressure in Hypertensive Disorders of Pregnancy
Status: COMPLETED
Conditions: Hypertension in Pregnancy
Interventions: DIAGNOSTIC_TEST: Invasive blood pressure assessment by radial artery canulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rezvilutamide Plus Abiraterone for Metastatic Hormone-sensitive Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Hormone-Sensitive Prostate Cancer
Interventions: DRUG: Rezvilutamide|DRUG: Rezvilutamide plus abiraterone|DRUG: Continue previous treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regeneration in Cervical Degenerative Myelopathy
Status: RECRUITING
Conditions: Myelopathy|Spinal Cord Diseases
Interventions: DRUG: Ibudilast|PROCEDURE: Cervical decompressive surgery|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Volar Locking Plates in Patients Under 65 With a Distal Radius Fracture
Status: UNKNOWN
Conditions: Distal Radius Fracture
Interventions: PROCEDURE: Surgical Repair of Distal Radius Fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Subtalar Joint Pronation Amount on Lower Extremity Alignment and Performance
Status: COMPLETED
Conditions: Balance Disorders|Foot Injury|Lower Extremity Problem
Interventions: OTHER: Foot Posture Index-6
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Durvalumab and Grid Therapy for Non-small Cell Lung Cancer in Progression During or After Treatment With PACIFIC Regimen
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Stage III Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Durvalumab|RADIATION: Radiation Therapy|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: CXL-1427 Ascending Dose|OTHER: Placebo|DRUG: CXL-1427 Descending Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Is Diverting Loop Ileostomy Necessary in Completion Proctectomy With Ileal Pouch Anal- Anastomosis: A Multicentre, Randomized Study of the GETAID Chirurgie Group. IDEAL Trial
Status: RECRUITING
Conditions: Ulcerative Colitis|Ileostomy - Stoma
Interventions: PROCEDURE: ileal pouch-anal anastomosis with diverting loop ileastomy|PROCEDURE: ileal pouch-anal anastomosis with diverting loop ileastomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interest of Topical Spironolactone's Administration to Prevent Corticoid-induced Epidermal Atrophy
Status: COMPLETED
Conditions: Cutaneous Atrophy Due to Corticosteroids
Interventions: DRUG: Clobetasol + Spironolactone|DRUG: Clobetasol + Placebo|DRUG: Placebo + Spironolactone|DRUG: Placebo + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Thalidomide in Preventing CINV Induced by Cisplatin-containing Chemotherapy
Status: UNKNOWN
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Thalidomide|DRUG: Dexamethasone|DRUG: 5-HT3 antagonists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Medicated Aerosol Delivery Using A Jet Nebulizer Versus A Vibrating Mesh Nebulizer in COPD Exacerbation
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Vibrating Mesh Nebulizer|DEVICE: Jet Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of SGLT2 Inhibitors in Heart Transplant Recipients
Status: ENROLLING_BY_INVITATION
Conditions: Transplant; Failure, Heart|Cardiac Allograft Vasculopathy|Rejection Heart Transplant
Interventions: DRUG: SGLT2i
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
Status: RECRUITING
Conditions: Down Syndrome|Obstructive Sleep Apnea
Interventions: DEVICE: Inspire Upper Airway Stimulation (UAS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Treatment for Advanced Liver Cancer
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma|Hepatic Portal Vein Tumor Invasion
Interventions: PROCEDURE: chemoembolization|DEVICE: endovascular stents implantation|PROCEDURE: iodine-125 seed strand implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe
Status: COMPLETED
Conditions: Meningococcal Infections
Interventions: BIOLOGICAL: MenACYW conjugate vaccine|BIOLOGICAL: Meningococcal group A, C, W-135, and Y conjugate vaccine|BIOLOGICAL: DTaP-IPV-HB-Hib vaccine|BIOLOGICAL: Pneumococcal vaccine (13-valent)|BIOLOGICAL: Pneumococcal vaccine (10-valent)|BIOLOGICAL: MMR vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Continuous 28-day (28/28) Temozolomide Chemotherapy in Subjects With Recurrent Malignant Glioma Who Have Failed the Conventional 5-day (5/28) Treatment (P04601)
Status: COMPLETED
Conditions: Glioma|Astrocytoma|Oligodendroglioma|Glioblastoma
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis
Status: NOT_YET_RECRUITING
Conditions: Periodontal Diseases
Interventions: DRUG: cyproterone Acetate/Ethinyl Estradiol Combination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Siltuximab for the Prevention of Severe Immune-Related Adverse Events During Immune Checkpoint Inhibitor Rechallenge in Patients With Advanced Cancer, CIRES Trial
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphatic System Neoplasm
Interventions: BIOLOGICAL: Anti-PD-L1 Monoclonal Antibody|BIOLOGICAL: Anti-PD1 Monoclonal Antibody|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Siltuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies
Status: RECRUITING
Conditions: B-cell Lymphoma|Non Hodgkin Lymphoma|DLBCL|Primary Mediastinal Large B Cell Lymphoma|Marginal Zone Lymphoma|Follicular Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: ACE1831|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemotherapy Compared With Oral Chemotherapy in the Treatment of Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Transarterial chemotherapy|DRUG: Oral chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Autoimmune Disorder|Rheumatoid Arthritis|Systemic Lupus Erythematosus|Primary Sjögren's Syndrome
Interventions: DRUG: branebrutinib|DRUG: abatacept|DRUG: branebrutinib placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Allogeneic Mesenchymal Cells From Umbilical Cord Tissue in Patients With COVID-19
Status: WITHDRAWN
Conditions: COVID
Interventions: BIOLOGICAL: Mesenchymal cells|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine an Effective Dose of Epoetin Alfa to Decrease the Number of Units of Blood Required to be Transfused During Hip Replacement Surgery.
Status: WITHDRAWN
Conditions: Anemia|Blood Transfusion|Orthopedic Surgery
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Radiotherapy for Patients With IIIA (N2) Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Thoracic Neoplasms|Non-small Cell Lung Cancer
Interventions: RADIATION: Postoperative 3D-CRT or IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Gingivitis Effects of Various Dentifrices
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: 0.76% Sodium Monofluorophosphate Dentifrice|DRUG: 1.15% Sodium Monofluorophosphate Dentifrice|DRUG: 0.454% Stannous Fluoride Dentifrice|DRUG: 0.454% Stannous Fluoride Dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HLA-mismatched Microtransplantation for High Risk Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: idarubicin|BIOLOGICAL: microtransplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride, Dasatinib, and Erlotinib Hydrochloride in Treating Patients With Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Pancreatic Cancer AJCC v6 and v7
Interventions: DRUG: Dasatinib|DRUG: Erlotinib Hydrochloride|DRUG: Gemcitabine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: semaglutide|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M-Health Administered Sleep Treatment to Enhance Recovery in Bariatric Populations (MASTER)
Status: UNKNOWN
Conditions: Insomnia|Morbid Obesity
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Y-shape Pegylated Somatropin in Growth Hormone Deficiency Children
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: Y-shape pegylated somatropin|DRUG: Y-shape pegylated somatropin|DRUG: Y-shape pegylated somatropin|DRUG: Norditropin®|DRUG: Y-shape pegylated somatropin|DRUG: Norditropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Functional, Neuroplastic and Biomechanical Changes Induced by an Intensive, Playful Early-morning Treatment Including Lower Limbs (EARLY-HABIT-ILE) in Preschool Children With Uni and Bilateral Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: MRI|OTHER: Electro-Encephalography-High Density (children with unilateral PC only)|OTHER: 3D and EMG analysis|OTHER: care and classic activities|DEVICE: Accelerometers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-Optimization Study Evaluating the Efficacy, Safety and Tolerability of Vyvanse (Lisdexamfetamine Dimesylate) in Children Aged 6-12 Diagnosed With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: Vyvanse (lisdexamfetamine dimesylate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Wellbeing: The Five Ways to All Intervention
Status: COMPLETED
Conditions: Wellbeing|Health Attitude|Quality of Life
Interventions: BEHAVIORAL: 5waysA Intervention|BEHAVIORAL: 5waysA Active wait-list control|BEHAVIORAL: 5waysA Inactive wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Functional Outcomes of Voice Recognition Prosthesis
Status: COMPLETED
Conditions: Prosthesis|Amputation|Prosthesis User
Interventions: DEVICE: Voice Activated Prosthetic Interface (VAPI) Controller
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Oxytocin Intranasal Administrations in Children With Prader-Willi Syndrome Aged From 3 to 12 Years
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Oxytocin|DRUG: Placebo|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: VS-6063|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ambulatory BP Monitoring on the CliniCal coUrse and RenAl ouTcomE of CKD
Status: UNKNOWN
Conditions: Chronic Kidney Diseases|Renal Insufficiency, Chronic|Albuminuria|Hypertension
Interventions: DEVICE: Ambulatory blood pressure monitoring (ABPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment, Feedback, Incentive, Exchange (AFIX OB) A Customizable Quality Improvement Intervention to Increase Maternal Vaccine Uptake
Status: COMPLETED
Conditions: Influenza|Whooping Cough
Interventions: BEHAVIORAL: AFIX-OB Quality Improvement Package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acetyl-L-Carnitine for the Treatment of NRTI-Associated Peripheral Neuropathy
Status: COMPLETED
Conditions: HIV Infections|Peripheral Nervous System Diseases
Interventions: DRUG: Acetyl-L-carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Aripiprazole and Risperidone for the Treatment of People With First-Episode Psychosis
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue
Status: COMPLETED
Conditions: Post-Acute COVID19 Syndrome|Fatigue
Interventions: BEHAVIORAL: Adhera® Fatigue Digital Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sensitivity and Specificity of NGS in Detecting bMSI in Patients With Gastric, Duodenal and Small Intestinal Cancer
Status: UNKNOWN
Conditions: Gastrointestinal Cancer
Interventions: DIAGNOSTIC_TEST: Next generation sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BTRX-246040 Study in Subjects With Parkinson's Disease With Motor Fluctuations
Status: COMPLETED
Conditions: Parkinson Disease|Motor Disorder
Interventions: DRUG: BTRX-246040|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glucagon-like Peptide-1 Agonism With Very Low Calorie Diets
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus in Obese
Interventions: DRUG: Semaglutide Pen Injector [Ozempic]|DIETARY_SUPPLEMENT: Very-low Calorie Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children
Status: TERMINATED
Conditions: Chronic Sinusitis|Adenoid Disease - Chronic
Interventions: PROCEDURE: Endoscopic Sinus surgery|PROCEDURE: Adenoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Topical Recombinant Human Thrombin(rhThrombin) for Surgical Hemostasis
Status: COMPLETED
Conditions: Surgical Hemostasis
Interventions: BIOLOGICAL: recombinant human Thrombin(CHO cell)|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-Inhibitor
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]|DRUG: adalimumab|DRUG: placebo to tocilizumab|DRUG: placebo to adalimumab|DRUG: methotrexate|DRUG: folate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colorectal Cancer Screening Assessment Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Colocare Instruction Sheet: SAM + CAM SMOG|BEHAVIORAL: CDC Colorectal cancer screening for life brochure: SAM + CAM SMOG|BEHAVIORAL: Colocare Instruction Sheet: SAM + CAM - Superior rating SMOG - 5th Grade Level|BEHAVIORAL: CDC Colorectal Cancer Screening for Life Brochure: SAM + CAM - Superior rating SMOG - 5th Grade Level|BEHAVIORAL: Colocare Instruction Video: Modified SAM + CAM -Superior rating|BEHAVIORAL: Colocare Instruction Sheet: SAM + CAM Cloze Procedure|BEHAVIORAL: CDC Colorectal cancer screening for life brochure: SAM + CAM Cloze Procedure|BEHAVIORAL: Colocare Instruction Sheet: SAM + CAM - Superior rating Cloze Procedure|BEHAVIORAL: CDC Colorectal Cancer Screening for Life Brochure: SAM + CAM - Superior rating Cloze Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Air Barrier System for the Prevention of Surgical Site Infection
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DEVICE: Air Barrier System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BMS-247550 in Treating Patients With Cancers That Have Not Responded to Previous Therapy
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific|Neutropenia
Interventions: DRUG: BMS-247550|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: MRIdian "RADAR" Trial
Status: NOT_YET_RECRUITING
Conditions: Metastatic Epidural Spinal Cord Compression|Spinal Cord Compression
Interventions: RADIATION: ViewRay MRIdian Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Safety, Tolerability And Pharmacokinetics of HS-10345 In Treatment-Resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depressive Disorder
Interventions: DRUG: HS-10345 84mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients
Status: UNKNOWN
Conditions: Microbial Colonization
Interventions: DRUG: Prebiotics|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Abacavir Pharmacokinetic Study in the Absence/Presence of Darunavir/Ritonavir or Raltegravir in HIV-infected Subjects
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Abacavir|DRUG: Darunavir/ritonavir|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid as an Intervention in Abruptio Placenta
Status: COMPLETED
Conditions: Vaginal Bleeding|Prolonged Pregnancy
Interventions: DRUG: Tranexamic acid injection|OTHER: Glucose water 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Resistance Exercise and Hydrolyzed Collagen Supplementation
Status: COMPLETED
Conditions: Diet, Food, and Nutrition
Interventions: DIETARY_SUPPLEMENT: Experimental: Consumption of three different doses of hydrolyzed collagen (HC) with reistance exercise|DIETARY_SUPPLEMENT: Experimental: Consumption of two different doses of hydrolyzed collagen (HC) with reistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Tanespimycin (KOS-953) in Patients With Relapsed-refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: tanespimycin|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Benralizumab Added to High-dose Inhaled Corticosteroid Plus LABA in Patients With Uncontrolled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT