pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Preoperative Turning in Bed and Mobilization Training on the Postoperative First Mobility
Status: COMPLETED
Conditions: Postoperative Mobility
Interventions: BEHAVIORAL: Turning in Bed|BEHAVIORAL: Mobilization|OTHER: information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Daily Use of The Emanate Tray Adjunct to Full Mouth Debridement Compared to Full Mouth Debridement Alone
Status: COMPLETED
Conditions: Wound Heal|Mouth; Wound|Periodontal Inflammation
Interventions: DEVICE: Emanate Tray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Action of AMG 357 in Females With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: AMG 357|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NMRC-M3V-Ad-PfCA Vaccine - Clinical Trial 1
Status: COMPLETED
Conditions: Plasmodium Falciparum
Interventions: BIOLOGICAL: NMRC-M3V-Ad-PfCA|BIOLOGICAL: NMRC-MV-Ad-PfC, NMRC-M3V-Ad-PfCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of the Therapeutic Vaccine GI-5005 Versus Placebo for the Treatment of Chronic Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: BIOLOGICAL: GI-5005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors
Status: RECRUITING
Conditions: Cancer|Immune-related Adverse Event|Cardiac Abnormalities, Variable|Immune Checkpoint Inhibitor-Related Myocarditis|Diastolic Dysfunction|Atherosclerosis|Cardiotoxicity
Interventions: PROCEDURE: Cardiology consultation|DIAGNOSTIC_TEST: Chest Computed Tomography (CT) without contrast|PROCEDURE: Non-invasive endothelial function tests|PROCEDURE: Electrocardiogram|DIAGNOSTIC_TEST: Extra serum sample (7.5 mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Advanced Imaging Techniques in Aortic Stenosis
Status: WITHDRAWN
Conditions: Aortic Stenosis
Interventions: RADIATION: Cardiac I123-MIBG Scintigraphy|OTHER: Cardiac MRI|OTHER: Stress and rest Echocardiogram|OTHER: High Sensitivity Troponin I|OTHER: Brain Natriuretic Peptide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory
Status: UNKNOWN
Conditions: Central Nervous System Diseases
Interventions: DEVICE: Functional near infrared spectroscopy|DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edaravone on the Ischemia-Reperfusion(I/R) Injury in Kidney Transplantation Patients
Status: UNKNOWN
Conditions: Kidney Transplantation
Interventions: DRUG: Edaravone|DRUG: 0.9%%NaCl solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Technologically-Augmented Referrals to Mitigate Addiction Consequences
Status: COMPLETED
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Technology Augmented Treatment for Screening, Brief Intervention, Referral, and Treatment (SBIRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Effect of Noninvasive Brain Stimulation on Hypokinetic Dysarthria in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Transcranial magnetic stimulation- sham rTMS|DEVICE: Transcranial magnetic stimulation- real rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Anti-neutrophil Cytoplasm Antibodies Test
Status: UNKNOWN
Conditions: Immunological Testing in Small-vessel Vasculitis
Interventions: DIAGNOSTIC_TEST: Indirect immunofluorescence (IIF) , myeloperoxidase antibody(MPO)- and anti-proteinase 3 (PR3-) ANCA immunoassays
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating Within-Person and Between-Person Effects Of A Personalized Normative Feedback Intervention On Drinking As They Are Moderated By Self-Determination
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: BEHAVIORAL: Alcohol-Specific Personalized Normative Feedback|BEHAVIORAL: Social Media Personalized Normative Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Plaque Composition in Patients With ST-Segment Elevation Myocardial Infarction (MI)
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Rosuvastatin 5mg|DRUG: Rosuvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Febrile Neutropenia|Sarcoma|Doxorubicin Adverse Reaction|Hospitalization-Associated Infection
Interventions: DEVICE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Randomized Evaluation of the Effectiveness of Clozapine and Aripiprazole Versus Clozapine and Haloperidol in the Treatment of Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracking Results of Ablations to Combat AF Registry Generation 2
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Concomitant Open Heart Surgical Ablation Procedures|DEVICE: Hybrid (Convergent) Ablation Procedures|DEVICE: AtriCure LAA Exclusion Procedures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive Disorder
Status: COMPLETED
Conditions: Bipolar Depression|Major Depressive Disorder
Interventions: DRUG: Lumateperone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Modification of Lifestyle in the Treatment of Ankylosing Spondylitis: a Pilot Study
Status: COMPLETED
Conditions: Arthritis|Rheumatic Diseases|Autoimmune Diseases
Interventions: DIETARY_SUPPLEMENT: Probiotic group|OTHER: Exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ulmus Macrocarpa Hance Extract and Lipid Profile
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DIETARY_SUPPLEMENT: UMH extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Characteristics and Pathophysiology of Post-Traumatic Headache
Status: COMPLETED
Conditions: Post-Traumatic Headache|Concussion, Mild
Interventions: DRUG: Calcitonin Gene-Related Peptide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Protein-rich Nutritional Therapy Combined With Time-efficient Exercise in Cancer Therapy
Status: UNKNOWN
Conditions: Cancer|Cancer Cachexia|Inflammation
Interventions: OTHER: Resistance Training|OTHER: WB-EMS|OTHER: High-intensity interval training (HIIT)|OTHER: Combined HIIT and Resistance Training (Combi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Mesothelin-directed CAR-T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.
Status: UNKNOWN
Conditions: Solid Tumor, Adult
Interventions: BIOLOGICAL: anti-mesothelin CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted HD-tDCS to Improve Upper Limb Rehabilitation in SCI
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries|Spinal Cord Diseases
Interventions: DEVICE: High-definition Transcranial Direct Current Stimulation|DEVICE: Conventional Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study Evaluating Safety and Tolerability of SL-T10, GX-I7, and Pembrolizumab Triple Combination in mCRPC.
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC)
Interventions: BIOLOGICAL: SL-T10|BIOLOGICAL: GX-I7|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do Cobalt Chrome Stent and Paclitaxel-Eluting Stent Have Equivalent Clinical Result in Non-Complex Lesion?
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Taxus stent|DEVICE: Vision stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Homeopathy, Acupuncture or Anthroposophic Medicine in Women's Quality of Life
Status: UNKNOWN
Conditions: Anxiety|Depression|Premenstrual Tension|Hot Flashes|Muscular Diseases
Interventions: OTHER: World Health Organization Quality of Life Bref Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Safety, Efficacy and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric and Adult Subjects With Primary Generalized Tonic-Clonic (i.e., Grand Mal) Seizures.
Status: COMPLETED
Conditions: Generalized Tonic Clonic Seizures
Interventions: DRUG: Pregabalin Dose Level 1|DRUG: Pregabalin Dose Level 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden
Status: SUSPENDED
Conditions: Astrocytoma, IDH-Mutant, Grade 4|Diffuse Glioma|Glioblastoma, IDH-Wildtype|Secondary Glioblastoma
Interventions: BIOLOGICAL: Ipilimumab|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervical Traction vs. Active Management of 3rd Stage of Labor
Status: UNKNOWN
Conditions: Post Partum Hemorrhage
Interventions: DRUG: Oxytocin|DRUG: Oxytocin|PROCEDURE: cervical traction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Viral Hepatitis B and C Infection in Patients With Idiopathic Thrombocytopenic Purpura Treated With Triple Therapy
Status: UNKNOWN
Conditions: ITP - Immune Thrombocytopenic Purpura|Viral Hepatitis
Interventions: DRUG: triple therapy|DRUG: Steroids
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of the Treatment of Tension-type Headache With Manual and Manipulative Therapy
Status: COMPLETED
Conditions: Tension-type Headache
Interventions: OTHER: Manual Therapy|OTHER: Manual Therapy|OTHER: Manual Therapy|OTHER: placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
Status: COMPLETED
Conditions: Chronic Heart Failure|Coronary Artery Disease|PreDiabetes
Interventions: DRUG: Metformin Hydrochloride|OTHER: lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ondansetron, Metoclopramide and Granisetron on Perioperative Nausea and Vomiting in Patients Undergone Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery Candidate|Perioperative Complication|Nausea|Vomiting, Postoperative|Drug Effect
Interventions: DRUG: Metoclopramide|DRUG: Ondansetron|DRUG: Metoclopramide and Ondanteron|DRUG: Granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Epirubicin and Cyclophosphamide Followed By Docetaxel and Trastuzumab in Treating Women With HER2-Positive Stage III or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: epirubicin hydrochloride|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Randomized, Placebo-controlled Trial of Etanercept for 12 Months in Subjects With Inclusion Body Myositis
Status: COMPLETED
Conditions: Inclusion Body Myositis
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physician Disclosures in the Real World of Conflicting Interests
Status: COMPLETED
Conditions: Conflicts of Interest
Interventions: BEHAVIORAL: Disclosure Letter-RISKS|BEHAVIORAL: Disclosure Letter-BENEFITS|BEHAVIORAL: Disclosure Letter-RISKS AND BENEFITS|BEHAVIORAL: Disclosure Letter-NO RISKS OR BENEFITS|BEHAVIORAL: Letter-APPOINTMENT REMINDER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Development of a Monitoring Set-up and Algorithm Using Functional MRI (fMRI) and EEG for Prediction of Response to Repetitive Deep Transcranial Magnetic Stimulation (rDTMS) for Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson
Interventions: DEVICE: Brainsway Multiway deep TMS device (two channels)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capsaicin + Diclofenac Gel in Acute Back Pain or Neck Pain
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Diclofenac|DRUG: Capsaicin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamic Plantar Pressures Changes After Dry Needling in Flexor Digitorum Brevis Versus Non Emission Laser
Status: COMPLETED
Conditions: Flatfoot
Interventions: OTHER: Bilateral dry needling in latent trigger points of the Flexor digitorum Brevis Muscle|OTHER: Bilateral non emission Laser in latent trigger points of the Flexor digitorum Brevis Muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Tramadol/APAP Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: To Determine Bioequivalence Under Fasting Conditions
Interventions: DRUG: Tramadol APAP|DRUG: Ultracet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Parental Behavior on Child Anxiety Regulation
Status: COMPLETED
Conditions: Separation Anxiety Disorder|Social Phobia|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Family cognitive behavioral therapy|BEHAVIORAL: Child-focused cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind 2-arm NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
Status: RECRUITING
Conditions: Sjogrens Syndrome
Interventions: DRUG: Ianalumab (VAY736)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Different Doses of BI 765049 When Given Alone and When Given With Ezabenlimab to Patients With Advanced Solid Tumors Expressing the Protein B7-H6 on the Cell Surface
Status: RECRUITING
Conditions: Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms, Carcinoma, Hepatocellular, Head and Neck Neoplasms, Gastrointestinal Neoplasms
Interventions: DRUG: BI 765049|DRUG: ezabenlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Ramosetron|DRUG: Naloxone|DRUG: saline|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Usefulness of a PRN Regimen Using Ranibizumab for Macular Edema Due to Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complications Associated With Promontofixation for Pelvic Organ Prolapse: Comparing Robot Assisted Laparoscopic and Non-robot Assisted Laparoscopic Surgical Procedures
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Robot-assisted promontofixation|PROCEDURE: Non-robot assisted promontofixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FDG Metabolism in Dementia With Lewy Body (DLB) Patients as Indicated by PET Dynamic Acquisition
Status: UNKNOWN
Conditions: Dementia With Lewy Bodies
Interventions: DIAGNOSTIC_TEST: PET-CT FDG brain scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rituximab, Yttrium Y 90 Ibritumomab Tiuxetan, Melphalan, and Autologous Peripheral Stem Cell Transplant in Treating Patients With Previously Treated Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: rituximab|DRUG: melphalan|BIOLOGICAL: Stem Cell|BIOLOGICAL: Sargramostim (GM-CSF)|RADIATION: 90Y-Zevalin|BIOLOGICAL: 111In Zevalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predicting Illness Trajectories In Fully Remitted Major Depression Using Concurrent TBS/fNIRS
Status: NOT_YET_RECRUITING
Conditions: Major Depression in Remission|Healthy
Interventions: DEVICE: Theta-burst stimulation (TBS)|OTHER: telephone interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia
Status: RECRUITING
Conditions: T-Cell Large Granular Lymphocyte Leukemia
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Benefits of Intraoperative Nociception Level (NOL) Titration - Pilot
Status: COMPLETED
Conditions: Nociceptive Pain
Interventions: DEVICE: NOL Guided Analgesia|OTHER: Routine opioid management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Recommendations for Exercise to Prevent Weight Regain
Status: COMPLETED
Conditions: Overweight|Obesity|Weight Loss
Interventions: BEHAVIORAL: 150 Min/Week|BEHAVIORAL: 225 Min/Week|BEHAVIORAL: 300 Min/Week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Synergistic Enteral Regimen for Treatment of the Gangliosidoses
Status: TERMINATED
Conditions: GM1 Gangliosidoses|GM2 Gangliosidoses|Tay-Sachs Disease|Sandhoff Disease
Interventions: DRUG: miglustat|OTHER: Ketogenic Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling and Maitland Joint Mobilization Techniques in Patients With Myofacial Chronic Neck Pain
Status: COMPLETED
Conditions: Myofacial Pain|Neck Pain
Interventions: OTHER: Dry Needling|OTHER: Maitland Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Yili Mei Yi Tian Active Lactobacillus Drink to Improve Immunity and Digestive System
Status: COMPLETED
Conditions: Immunization|Human Influenza|Common Cold|Constipation|Dyspepsia|Flatulence|Abdominal Pain
Interventions: DIETARY_SUPPLEMENT: Yili "Mei Yi Tian" active lactobacillus drink|DIETARY_SUPPLEMENT: recombined milk drink contains no lactobacillus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Markers of Oxidative Stress in Inflammatory Bowel Diseases: Risk Factors and Implications for a Dietetic Approach
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases
Interventions: DIETARY_SUPPLEMENT: Antioxidant diet|DIETARY_SUPPLEMENT: Normal dietetic scheme
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Differentiated Access to Out-of-hours Primary Care Through Emergency Access
Status: COMPLETED
Conditions: After-hours Care
Interventions: BEHAVIORAL: Akutknappen - used|BEHAVIORAL: Akutknappen - not used
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prospective Cohort Study on Tolerability & Safety of Uro-Tainer® Polihexanide 0.02%
Status: TERMINATED
Conditions: Complications; Catheter, Urinary (Indwelling Catheter) (Suprapubic)
Interventions: DEVICE: Uro-Tainer Polihexanide 0.02%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Choline-PET: Exploratory Study Assessing the Potential Role of F-choline PET Imaging in New and Emerging Indications
Status: RECRUITING
Conditions: Lesion With Known or Suspected F-choline Uptake
Interventions: DRUG: F-choline intravenous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Abdominal CT to Predict the Risk of Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Leukemia, Myeloid, Acute|Leukemia, Myelogenous, Chronic|Multiple Myeloma
Interventions: RADIATION: Dynamic contrast-enhanced computed tomography|DRUG: Ioversol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Krill Oil as Supplementation to Healthy Young Adults.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Krill oil low dose|DIETARY_SUPPLEMENT: Krill oil high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Bangladesh Environmental Enteric Dysfunction Study
Status: UNKNOWN
Conditions: Malnutrition|Infection
Interventions: DIETARY_SUPPLEMENT: Egg|DIETARY_SUPPLEMENT: Milk|DRUG: Albendazole/Pyrantel Pamoate|BEHAVIORAL: Nutritional counselling|DIETARY_SUPPLEMENT: Micronutrient sprinkles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD
Status: RECRUITING
Conditions: End-stage Kidney Disease|Kidney Disease, Chronic|Dialysis|Diabetic|Non-diabetic|Kidney Dysfunction|Kidney Failure|Hemodialysis
Interventions: DRUG: Empagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders
Status: COMPLETED
Conditions: Sleep Disorders|Non-Erosive Reflux Disease|Gastroesophageal Reflux Disease
Interventions: DRUG: Pantoprazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of Antiepileptics in Patients on CRRT
Status: COMPLETED
Conditions: Acute Kidney Injury|Renal Insufficiency|Renal Failure|Pharmacokinetics
Interventions: DRUG: Levetiracetam|DRUG: Lacosamide|DRUG: Phenytoin|DRUG: Phenobarbital|DRUG: Ketamine|DRUG: Valproic Acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurodegenerative Diseases|Alzheimer Disease|Frontotemporal Dementia|Lewy Body Disease|Vascular Dementia|Parkinson Disease|Progressive Supranuclear Palsy|Corticobasal Degeneration|Multiple System Atrophy|Amyotrophic Lateral Sclerosis|Huntington Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Instrument-Assisted Soft Tissue Mobilization Technique on Flexibility and Thickness by Compression Elastography Method in Healthy Individuals.
Status: UNKNOWN
Conditions: Instrument-assisted Soft Tissue Mobilization|Flexibility|Thickness|Compression Elastography|Rehabilitation
Interventions: OTHER: Observational|OTHER: IASTM Technique Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DART I - A Phase IV Study of 3 Antiretroviral Medicines in Combination, in HIV Patients Who Have Not Been Previously Treated With Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV Infections|AIDS
Interventions: DRUG: efavirenz; didanosine EC; lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib and White Blood Cell Therapy for Advanced Melanoma
Status: TERMINATED
Conditions: Metastatic Cancer|Melanoma
Interventions: DRUG: Vemurafenib|BIOLOGICAL: Young TIL|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Amyotrophic Lateral Sclerosis (ALS) With R(+) Pramipexole Dihydrochloride Monohydrate at 60 mg/Day
Status: TEMPORARILY_NOT_AVAILABLE
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: R(+) pramipexole dihydrochloride monohydrate
Study Type: EXPANDED_ACCESS
Clinical trial: Concomitant Hybrid Versus Catheter Ablation for Atrial Fibrillation With Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Atrial Fibrillation|Cardiomyopathy, Hypertrophic|Radiofrequency Ablation
Interventions: PROCEDURE: hybrid ablation|PROCEDURE: catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Learning and Ear Stimulation
Status: COMPLETED
Conditions: Learning|taVNS
Interventions: DEVICE: transcutaneous auricular vagus nerve stimulation (taVNS) 15 minutes|DEVICE: taVNS 30 minutes|DEVICE: taVNS 45 minutes|DEVICE: taVNS 60 minutes|DEVICE: taVNS 75 minutes|DEVICE: taVNS 0 minutes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm
Status: RECRUITING
Conditions: Preterm|Infant Death
Interventions: PROCEDURE: Umbilical cord milking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Trial of Effects of DAIry PROtein Products on Liver Disease Severity and Metabolism in Patients With Non-Alcoholic Fatty Liver Disease.
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease|Metabolic Syndrome|Caseins|Whey|Diet, High Protein|Weight Loss|Lipoproteins, VLDL
Interventions: DIETARY_SUPPLEMENT: High-Protein Diet|BEHAVIORAL: Clinical dietician|BEHAVIORAL: Weight loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Amphotericin B With or Without Sargramostim in Treating Patients With Invasive Fungal Infection
Status: COMPLETED
Conditions: Infection
Interventions: BIOLOGICAL: sargramostim|DRUG: liposomal amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intergenerational Transmission of Traumatic Stress
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress, Psychological|Stress Disorders, Traumatic|Emotion Regulation|Behavior, Child|Emotional Stress|Trauma, Psychological|Anxiety|Depression|Coping Skills|Parent-Child Relations|Parenting
Interventions: BEHAVIORAL: Families OverComing Under Stress (FOCUS) for Early Childhood (FOCUS-EC)|OTHER: Parenting Education Website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nystagmus Assessment for Patients Consulting in the Emergency Department for Acute Vertigo
Status: ACTIVE_NOT_RECRUITING
Conditions: Nystagmus, Acquired|Stroke, Acute
Interventions: DEVICE: Frenzel Lens|DIAGNOSTIC_TEST: Diagnostic Algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bevacizumab and Capecitabine as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab Combined With ESHAP in Patients With Relapse or Refractory Diffuse Large B Cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Rituximab combined with ESHAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (PEG)-BHD1028
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: (PEG)-BHD1028 Single Ascending Dose|DRUG: (PEG)-BHD1028 Multiple Ascending Dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Psychology Intervention for Patients Post-bariatric Surgery and Their Partners
Status: RECRUITING
Conditions: Obesity, Morbid
Interventions: BEHAVIORAL: Reimagining Us in the Context of Bariatric Surgery (ReConnect)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective, Multicenter, Post-marketing Clinical Follow-up Research to Evaluate the Long-term Safety of Ellansé-S Dermal Filler Made of PCL Microspheres for the Correction of Moderate-to-severe Nasolabial Folds
Status: ENROLLING_BY_INVITATION
Conditions: Moderate-to-severe Nasolabial Folds (3-4 Level of WSRS Scores) on Both Sides of the Face
Interventions: DEVICE: Ellansé-S
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Two Resin Composites and Two Adhesives for a Novel Restorative Protocol to Treat Cervical Lesions
Status: COMPLETED
Conditions: Dental Abrasion|Gingival Recession|Composite Resins
Interventions: PROCEDURE: Periodontal surgery|PROCEDURE: Total Etch adhesive|PROCEDURE: Universal Adhesive|PROCEDURE: Nanofilled Composite|PROCEDURE: Micro-Hybrid Composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Mobile App for Peer-led Seeking Safety
Status: COMPLETED
Conditions: Substance Use Disorders|PTSD|Trauma|Emotional Dysfunction
Interventions: BEHAVIORAL: Peer-Led Seeking Safety app|BEHAVIORAL: Control app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect Of Pregabalin Treatment In Patients With Diabetic Nerve Pain Who Currently Use A Non-Steroid Anti-Inflammatory Drug (NSAID) For Another Pain
Status: COMPLETED
Conditions: Painful Diabetic Peripheral Neuropathy
Interventions: DRUG: pregabalin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab Plus Methotrexate With or Without Lenalidomide in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma
Status: RECRUITING
Conditions: PCNSL
Interventions: DRUG: Rituximab|DRUG: Lenalidomide|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Interventions in Neuro-Rehabilitation: Gotcha!
Status: RECRUITING
Conditions: Dementia|Alzheimer Disease|Anomia
Interventions: OTHER: Gotcha! Therapy application|OTHER: Gotcha Therapy application: Maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: 64Cu-DOTATATE-PET for Lyme Neuroborreliosis
Status: RECRUITING
Conditions: Borrelia Burgdorferi Neuroborreliosis
Interventions: DIAGNOSTIC_TEST: Cu DOTATATE PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Gastrointestinal Function In High-Risk Newborns By Stimulation Of The Enteric Nervous System
Status: RECRUITING
Conditions: Feeding and Eating Disorders
Interventions: PROCEDURE: HAPTOS (Handling Adapted to Postnatal age with Tactile-kinaesthetic and Oral sensorimotor Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RC48-ADC in Advanced Melanoma Subjects With HER2 Variant (Mutation, Amplification, Overexpression)
Status: RECRUITING
Conditions: Melanoma, Stage II|HER2-positive|Advanced Melanoma
Interventions: DRUG: RC48-ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naproxen Sodium ER Pharmacokinetic Study
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Naproxen sodium ER (BAYH6689)|DRUG: Commercial Naproxen (Aleve, BAYH6689)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Transcutaneous Spinal Cord Stimulation|BEHAVIORAL: Arm-crank bike exercise|OTHER: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy in Cancers With Mutations in DNA Repair Genes
Status: RECRUITING
Conditions: Metastatic Solid Tumor|BRCA1 Mutation|BRCA2 Mutation|ATM Gene Mutation|PALB2 Gene Mutation
Interventions: DRUG: Niraparib|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Mesenchymal Progenitor Cell Exosomes Nebulizer for the Treatment of Pulmonary Infection
Status: SUSPENDED
Conditions: Drug-resistant
Interventions: BIOLOGICAL: Dosage 1 of MPCs-derived exosomes|BIOLOGICAL: Dosage 2 of MPCs-derived exosomes|BIOLOGICAL: No MPCs-derived exosomes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of NIBS for Treatment of Addiction
Status: RECRUITING
Conditions: Opioid-use Disorder|Chronic Pain
Interventions: DEVICE: Active Comparator: Active tDCS + Active TUS|DEVICE: Sham Comparator: Sham tDCS + Sham TUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elesclomol Sodium and Paclitaxel in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube Mucinous Adenocarcinoma|Fallopian Tube Serous Adenocarcinoma|Fallopian Tube Transitional Cell Carcinoma|Fallopian Tube Undifferentiated Carcinoma|Ovarian Brenner Tumor|Ovarian Clear Cell Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Adenocarcinoma|Ovarian Seromucinous Carcinoma|Ovarian Serous Adenocarcinoma|Ovarian Transitional Cell Tumor|Ovarian Undifferentiated Carcinoma|Primary Peritoneal Serous Adenocarcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Elesclomol Sodium|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sample Collection for Evaluation of the Panbio™ COVID-19/ Flu A&B Rapid Panel.
Status: COMPLETED
Conditions: COVID-19|Influenza A|Influenza Type B
Interventions: DIAGNOSTIC_TEST: Nasal and Nasopharyngeal Sampling of the Panbio™ COVID-19/ Flu A&B Rapid Panel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: DRy Eye Outcome and Prescription Study
Status: UNKNOWN
Conditions: Dry Eye|Dry Eye Syndrome|Blepharitis|Meibomian Gland Dysfunction|Eye Pain|Punctate Epithelial Keratitis|Punctate Keratitis|Tear Film Insufficiency|Kerato Conjunctivitis Sicca|Eye Diseases
Interventions: DEVICE: Artificial tears (classified by MHRA as a medical device)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Infraclavicular Brachial Plexus Block With Bupivacaine Alone or With Both Dexmedetomidine and Dexamethasone
Status: NOT_YET_RECRUITING
Conditions: Upper Extremity Injury
Interventions: DRUG: Bupivacaine injection|DRUG: Bupivacaine+ Dexamethasone+ Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Can Training Increase Reporting Accuracy and Study Power in Human Pain Trials
Status: UNKNOWN
Conditions: Healthy|Placebo Response
Interventions: DRUG: Ibuprofen 400 mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Combining Varenicline and Naltrexone for Smoking Cessation
Status: COMPLETED
Conditions: Nicotine Dependence|Alcohol Use Disorder
Interventions: DRUG: Varenicline|DRUG: Varenicline plus Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Seprafilm in the Reduction of Incidence of Bowel Obstruction in General Surgery
Status: COMPLETED
Conditions: Intestinal Obstruction|Digestive System Surgical Procedures
Interventions: DEVICE: Seprafilm Bioresorbable Membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacokinetics Study of Ustekinumab Biosimilar GNR-068 and Stelara® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: GNR-068|BIOLOGICAL: Stelara®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Fixed Combination Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene BPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Epidural Hydromorphone Compared With Hydromorphone Infusion in Treating Patients With Prostate Cancer Undergoing Radical Prostatectomy
Status: COMPLETED
Conditions: Pain|Prostate Cancer
Interventions: DRUG: hydromorphone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Women's Health Through Coordinated Postpartum Planning
Status: ACTIVE_NOT_RECRUITING
Conditions: Maternal Death|Maternal Morbidity
Interventions: BEHAVIORAL: Enhanced Postpartum Care System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma
Status: COMPLETED
Conditions: Diabetic Retinopathy|Glaucoma, Neovascular
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment
Status: TERMINATED
Conditions: Neovascular (Wet) Age-related Macular Degeneration
Interventions: DRUG: Aflibercept(BAY86-5321, Eylea)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects
Status: UNKNOWN
Conditions: Acquired Immunodeficiency Syndrome|Lipodystrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective,Randomized,Controlled Study to Assess Efficacy,Safety, and Tolerability of SLT vs. PLT in Patients With POAG
Status: TERMINATED
Conditions: Glaucoma and Ocular Hypertension
Interventions: DEVICE: Selective laser trabeculoplasty (SLT)|DEVICE: Pattern laser trabeculoplasty (PLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentre 2x2 Factorial Randomised Study Comparing Tirofiban Versus Abciximab and SES Versus BMS in AMI
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: OTHER: abciximab followed by implantation of bare metal stent|OTHER: abciximab and Sirolimus eluting stent|OTHER: tirofiban and bare metal stent|OTHER: tirofiban and sirolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT