pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of Outcomes of Restoring Pelvic Floor Support With TOPAS in Women With Moderate Fecal Incontinence Symptoms
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DEVICE: TOPAS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Sodium Bicarbonate to Reduce the Incidence of Contrast Induced Chronic Kidney Injury in Patients With Kidney Disease
Status: TERMINATED
Conditions: Contrast Induced Kidney Injury.
Interventions: DRUG: sodium bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK2336805 Alone and With the Co-administration of TMC435 in Healthy Japanese Participants.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GSK2336805 30 mg|DRUG: GSK2336805 60 mg|DRUG: GSK2336805 120 mg|DRUG: TMC435 150 mg (Treatment A)|DRUG: GSK2336805 60 mg (Treatment B and part of Treatment C and D)|DRUG: TMC435 100 mg (part of Treatment C)|DRUG: TMC435 150 mg (part of treatment D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye
Status: COMPLETED
Conditions: Sjogren's Syndrome|Dry Eye|Ocular Surface Disease
Interventions: DRUG: Autologous serum tears combined with 0.05% cyclosporin eye drop
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Evaluate 1 Year Extension Study of the Efficacy and Safety of Tocilizumab in Patients With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: DMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential TACE and SBRT Followed by ImmunoTherapy for Downstaging HCC for Hepatectomy
Status: COMPLETED
Conditions: HCC
Interventions: PROCEDURE: TACE|RADIATION: SBRT|DRUG: Immune Checkpoint Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ponatinib Hydrochloride as Second Line Therapy in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib Mesylate, Dasatinib, or Nilotinib
Status: RECRUITING
Conditions: Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Ponatinib Hydrochloride|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-Fluciclovine PET Imaging for Detecting High Grade Glioma Recurrence After Radiochemotherapy
Status: RECRUITING
Conditions: Grade III or Grade IV Glioma
Interventions: DRUG: PET imaging with 18F fluciclovine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial of Neoadjuvant EndoTAG-1 in Combination With Paclitaxel in HER2-negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: EndoTAG-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plasma Concentration of Lidocaine and Bupivacaine Axillary BPB Mixture Solutions [PCLBAxMix]
Status: UNKNOWN
Conditions: Arm Injury
Interventions: DRUG: Lidocaine brachial plexus block|DRUG: Bupivacaine brachial plexus block|DRUG: Mixture brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation
Status: TERMINATED
Conditions: Alzheimers Disease|Dementia|Alzheimers Disease, Familial
Interventions: DRUG: Gantenerumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Tramadol Versus Oral Dexketoprofen for Reducing Pain During Office Hysteroscopy
Status: UNKNOWN
Conditions: Hysteroscopy
Interventions: DRUG: dexketoprofen|DRUG: Tramadol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radioembolization With Yittrium-90 for Intermediate and Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Radioembolization
Interventions: PROCEDURE: TACE|PROCEDURE: radioembolization with Y-90
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Adjuvant Statin Therapy in Patients Who Underwent Radical Prostatectomy for Locally Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Atorvastatin 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Ejaculatory Dysfunction in Men With Low Testosterone Levels
Status: COMPLETED
Conditions: Ejaculatory Dysfunction|Hypogonadism
Interventions: DRUG: Testosterone Solution 2%|DRUG: Placebo Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT of Mushroom Based Natural Product to Enhance Immune Response to COVID-19 Vaccination
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Vaccination
Interventions: DIETARY_SUPPLEMENT: FoTv
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microvascular Angina Intervention With Compound Danshen Dripping Pill (MAIDS)
Status: RECRUITING
Conditions: Microvascular Angina
Interventions: DRUG: Compound Danshen Dropping Pills|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of D3L-001 as Monotherapy in Subjects With HER2-Positive Advanced Solid Tumors
Status: RECRUITING
Conditions: HER-2 Positive Advanced Solid Tumors
Interventions: BIOLOGICAL: D3L-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CML
Status: NOT_YET_RECRUITING
Conditions: CML, Chronic Phase|Chronic Myeloid Leukemia, Chronic Phase|Chronic Myeloid Leukemia, BCR/ABL-Positive|Chronic Myeloid Leukemia
Interventions: DRUG: Asciminib|DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL).
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Adult B-Cell|Acute Lymphoblastic Leukemia, in Relapse|Non-Hodgkin Lymphoma, B-cell|Diffuse Large B Cell Lymphoma|Central Nervous System Lymphoma|Lymphoma, Follicular|MCL
Interventions: BIOLOGICAL: CD19/CD22-CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunct Episcleral Brachytherapy for PCV
Status: NOT_YET_RECRUITING
Conditions: Age-Related Macular Degeneration|Polypoid Choroidal Vasculopathy
Interventions: RADIATION: Episcleral Brachytherapy|DRUG: Aflibercept Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Effects of Oats and Oat Bioactive in Human
Status: COMPLETED
Conditions: Postprandial Glucose Regulation
Interventions: COMBINATION_PRODUCT: Oat Beverage 1|COMBINATION_PRODUCT: Oat Beverage 2|COMBINATION_PRODUCT: Oat Beverage 3|COMBINATION_PRODUCT: Oat Beverage 4|COMBINATION_PRODUCT: Control product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Early Laparoscopic Cholecystectomy Versus Percutaneous Cholecystostomy in Grade II Acute Cholecystitis Guidelines
Status: COMPLETED
Conditions: Acute Cholecystitis|Empyema, Gallbladder
Interventions: PROCEDURE: laparoscopic cholecystectomy|PROCEDURE: percutaneous cholecystostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study With Pembrolizumab in Combination With Dual Anti-HER2 Blockade With Trastuzumab and Pertuzumab in Early Breast Cancer Patients With Molecular HER2-enriched Intrinsic Subtype (Keyriched-1)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Trastuzumab Biosimilar ABP 980|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Trunk Postural Change on CO2 Removal Efficiency in ARDS Patients: Quasi-experimental Study
Status: COMPLETED
Conditions: ARDS
Interventions: OTHER: Ppostural change from 45° to 10° in supine position
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium
Status: COMPLETED
Conditions: Stomach Ulcer
Interventions: DRUG: E0671|DRUG: rabeprazole sodium|DRUG: E0671 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Afatinib in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of Esophagus
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of Esophagus
Interventions: DRUG: BIBW2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FATA: Randomized Study on Facilitated Angioplasty With Tirofiban or Abciximab
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: tirofiban high-bolus dose regimen|DRUG: Abciximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events
Status: COMPLETED
Conditions: Retinal Detachment|Achilles Tendon|Aneurysm, Dissecting
Interventions: DRUG: Oral Fluoroquinolones (FQ)|DRUG: Other Antibiotics|OTHER: Febrile Illness Not Treated with Antibiotics Will be Analyzed as an Exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Misoprostol Ripening Efficacy With Dilapan
Status: COMPLETED
Conditions: Labor Onset and Length Abnormalities|Induced; Birth
Interventions: DEVICE: Dilapan|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a
Status: COMPLETED
Conditions: ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)
Interventions: DRUG: CERC-501|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lamotrigine 25 mg Chewable Tablets, Non-Fasting
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lamotrigine 25 mg Chewable Tablets|DRUG: Lamictal® 25 mg Chewable Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Antiperistaltic Effect and Safety of L-menthol in the Elderly With Contraindication to Buscopan
Status: UNKNOWN
Conditions: Upper Gastrointestinal Endoscopy
Interventions: DRUG: L-menthol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of AT & PR Training to Improve Functional Ability After Breast Cancer Surgery
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Aerobic Training|DIAGNOSTIC_TEST: Progressive Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SHR-A1921 Combined With Adebrelimab in the Treatment of Advanced NSCLC Who Failed the Previous Standard First-line Treatment
Status: NOT_YET_RECRUITING
Conditions: NSCLC
Interventions: DRUG: SHR-A1921 injection and adebrelimab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9933 in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN9933|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of CAR-T Technology for the Treatment of Relapsed Refractory Malignant Haematological Tumours
Status: RECRUITING
Conditions: Hematological Malignancy
Interventions: DRUG: CAR-T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - Phase 2 Clinical Trial
Status: UNKNOWN
Conditions: Actinic Cheilitis|Leukoplakia|Erythroplakia
Interventions: DRUG: Metil 5-aminolevulinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Expression in Renal Transplant Patients With Field Actinic Keratosis Undergoing Metvix® Photodynamic Therapy (PDT)
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: PROCEDURE: Metvix PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PPI Therapy Impact on GERD After Sleeve Gastrectomy
Status: UNKNOWN
Conditions: Gastro Esophageal Reflux|Barrett Esophagus|Bariatric Surgery Candidate
Interventions: DRUG: Lansoprazole oral tablets 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia
Status: COMPLETED
Conditions: Arnold-Chiari Malformation, Type 1|Chiari Malformation Type I|Type I Arnold-Chiari Malformation|Syringomyelia
Interventions: PROCEDURE: Posterior fossa decompression|PROCEDURE: Dural Augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plant Based Protein and Whey Protein: Effects on Body Composition and Performance
Status: COMPLETED
Conditions: Protein Supplementation
Interventions: DIETARY_SUPPLEMENT: Plant based protein|DIETARY_SUPPLEMENT: Whey protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Compare the Effect on Cognitive Functioning of Two Formulations of Seroquel, Seroquel XR and IR in Patients With Stable Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Seroquel XR- quetiapine fumarate extended release|DRUG: Seroquel IR - quetiapine fumarate|DRUG: Placebo matching Seroquel XR|DRUG: Placebo matching Seroquel IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of VG-3927 in Healthy Adults
Status: ENROLLING_BY_INVITATION
Conditions: Healthy
Interventions: DRUG: VG-3927|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Adipose-Derived Stem Cell Injection Partial Thickness Rotator Cuff Tears
Status: COMPLETED
Conditions: Rotator Cuff Tear - Partial Thickness
Interventions: BIOLOGICAL: Adipose derived regenerative cells|DRUG: Cortisone Injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nintedanib for Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Patients
Status: UNKNOWN
Conditions: Telangiectasia, Hereditary Hemorrhagic
Interventions: DRUG: Nintedanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acalabrutinib Study in Indian Patients With Chronic Lymphocytic Leukaemia & Relapsed and Refractory Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia and Relapsed and Refractory Mantle Cell Lymphoma
Interventions: DRUG: Acalabrutinib capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients
Status: RECRUITING
Conditions: Extubation
Interventions: OTHER: Total intravenous anesthesia (TIVA)|OTHER: Sevoflurane initiated intravenous anesthesia (SIIVA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Conbercept in Macular Edema Secondary to Retinal Vein Occlusion
Status: UNKNOWN
Conditions: Retinal Vein Occlusion
Interventions: BIOLOGICAL: Conbercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Crosstrees Pod™ in the Treatment of Pathologic Fracture of the Vertebral Body (Levels T4 - L5) in Adult Patients
Status: COMPLETED
Conditions: Pathologic Fracture of the Vertebra Due to Osteoporosis
Interventions: DEVICE: Crosstrees Pod system for PVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Local Anesthetic Transversus Abdominis Plane (TAP) Blocks in Abdominal Surgery
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: US-Guided Ropivacaine TAP Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 24 Gy in One Fraction Urethral-sparing "HDR Like" SBRT for Prostate Cancer
Status: RECRUITING
Conditions: Localized Prostate Carcinoma
Interventions: RADIATION: prostate SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Docetaxel or Vinorelbine Plus Cisplatin in Neoadjuvant Chemoradiotherapy for Esophageal Cancer (NEOCRTEC308)
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Esophageal Cancer|Oesophageal Cancer
Interventions: DRUG: Docetaxel|DRUG: Cisplatin|RADIATION: Radiation|PROCEDURE: Surgery|DRUG: Vinorelbine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosing and Tolerability of Deoxycholic Acid Versus Polidocanol in the Treatment of Neurofibromatosis Type 1 Cutaneous Neurofibromas
Status: RECRUITING
Conditions: Neurofibromatosis 1
Interventions: DRUG: Kybella|DRUG: Asclera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Limiting Emergence Phenomena After General Anesthesia With Combined LMA and ETT Airway Management Technique
Status: RECRUITING
Conditions: Limit Emergence Phenomena After General Anesthesia
Interventions: PROCEDURE: Induction of anesthesia|DEVICE: Placement of LMA [Ambu (R) AuraGain (TM) disposable laryngeal mask]|DEVICE: Laryngoscopy and placement of ETT|PROCEDURE: Ventilation via the ETT|PROCEDURE: Removal of the ETT|PROCEDURE: Intubation of the trachea through the LMA|PROCEDURE: Ventilation via the LMA|PROCEDURE: Emergence from anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug-Drug Interaction Study Between CJ-12420 and Clarithromycin in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CJ-12420 200mg + Clarithromycin 500mg|DRUG: CJ-12420 200mg|DRUG: Clarithromycin 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Duramesh™ vs Polydioxanone Suture for Laparotomy Closure
Status: RECRUITING
Conditions: Laparotomy Closure After Abdominal Surgery
Interventions: DEVICE: Duramesh|DEVICE: Polydioxanone suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Preoperative Intra Gastric Balloon in Morbidly Obese Patients Selected for Gastric By-pass
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DEVICE: inflatable intra-gastric balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Methamphetamine on Residual Latent HIV Disease Study
Status: COMPLETED
Conditions: HIV-1-infection|Methamphetamine-dependence
Interventions: DRUG: Oral Methamphetamine|OTHER: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of VMCore Biopsy Versus Standard of Care Biopsy
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DEVICE: VMCore Biopsy System|DEVICE: Standard of Care Biopsy Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Feasibility and Acceptability of Digital Pills to Monitor PrEP Adherence in MSM With Substance Use
Status: COMPLETED
Conditions: HIV/AIDS|Substance Use Disorders|Adherence, Medication
Interventions: DEVICE: Digital pill|DRUG: Truvada
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial Analyzing the Efficacy of Oral Administration of Tranexamic Acid in Spine Surgery.
Status: COMPLETED
Conditions: Tranexamic Acid (TXA)|Prospective Study|Evidence-based Medicine|Randomized Controlled Trial
Interventions: DRUG: Tranexamic Acid Oral Product|DRUG: Placebo pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
Status: RECRUITING
Conditions: Suicide|Suicidal|Suicide, Attempted|Suicidal Ideation|Depression|Anxiety|Aggression|Trauma, Psychological
Interventions: BEHAVIORAL: MHSAFE app recording
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HLA and it Relation With the Development of Proliferative Diabetic Retinopathy in Mexican Population
Status: WITHDRAWN
Conditions: Diabetes Mellitus Type 2|Proliferative Diabetic Retinopathy
Interventions: PROCEDURE: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: A Media Based Motivational Intervention to Prevent Alcohol Exposed Pregnancies (AEPs)
Status: COMPLETED
Conditions: Alcohol Consumption|Fetal Alcohol Syndrome Disorders|Students
Interventions: BEHAVIORAL: Self-guided Motivational Intervention|BEHAVIORAL: Informational Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Exposure Therapy for Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Prolonged Exposure|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coenzyme Q-10 and Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q-10 in Pulmonary Hypertension subjects|DIETARY_SUPPLEMENT: Coenzyme Q-10 in Normal Control subjects
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin in Pregnant PCOS Women
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of VX-985 in Subjects With Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: VX-985 or matching placebo|DRUG: VX-985 or matching placebo|DRUG: VX-985 or matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Allogeneic Blood Stem Cell Transplantation in High-risk Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Melphalan, ATG, Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual Hemisphere rTMS for Rehabilitation of Post Stroke Aphasia
Status: COMPLETED
Conditions: Non Fluent Aphasia in Subacute Stroke
Interventions: PROCEDURE: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose Pharmacokinetics and Safety Study of Ceftobiprole in Pediatric Patients =3 Months to <18 Years of Age
Status: COMPLETED
Conditions: Staphylococcal Skin Infections|Streptococcal Infections
Interventions: DRUG: Ceftobiprole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Fluoxetine in Refractory Constipation Treatment
Status: NOT_YET_RECRUITING
Conditions: Refractory Constipation
Interventions: DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Non Crossover Study of the GuardianTM Versus SupremeTM Laryngeal Mask Airway
Status: COMPLETED
Conditions: Adverse Anesthesia Outcome
Interventions: DEVICE: Guardian Laryngeal Mask|DEVICE: Supreme Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Diagnostic Accuracy of Ultrasound Compared to Epidurography for Epidural Catheter Localization"
Status: RECRUITING
Conditions: Open Abdominal Surgery|Epidural Analgesia
Interventions: DEVICE: Doppler color and M-Mode ultrasound|DEVICE: Epidurography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fluorescence Molecular Endoscopy and Molecular Fluorescence-guided Surgery in Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: DRUG: Cetuximab-IRDye800|DEVICE: Fluorescent molecular endoscopy and surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial
Status: TERMINATED
Conditions: Metastatic Colon Adenocarcinoma|Metastatic Rectal Adenocarcinoma|Stage III Colon Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Colon Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Colon Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Colon Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8|Stage IV Colon Cancer AJCC v8|Stage IV Rectal Cancer AJCC v8|Stage IVA Colon Cancer AJCC v8|Stage IVA Rectal Cancer AJCC v8|Stage IVB Colon Cancer AJCC v8|Stage IVB Rectal Cancer AJCC v8|Stage IVC Colon Cancer AJCC v8|Stage IVC Rectal Cancer AJCC v8|Unresectable Colon Adenocarcinoma|Unresectable Rectal Adenocarcinoma
Interventions: OTHER: Genetic Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Yoga-CBT Group Intervention for Adolescents With Chronic Pain and Their Caregivers
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Chronic Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|OTHER: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Strength Training on Freestyle Swimming Performance and Core Muscles Strength in Swimmers
Status: UNKNOWN
Conditions: Sports Physical Therapy
Interventions: OTHER: Experimental: Experimental group exercises|OTHER: No Intervention: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Respiration-induced Deformations in Visceral and Renal Arteries Before and After Stenting During Branched Stent Treatment.
Status: UNKNOWN
Conditions: Complex Aortic Aneurysms
Interventions: PROCEDURE: Angioscan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Radiotherapy With Leuprolide and Enzalutamide in High Risk Prostate Cancer
Status: TERMINATED
Conditions: Prostatic Neoplasms|Pelvic Nodal
Interventions: DRUG: Enzalutamide|DRUG: Leuprolide|RADIATION: Intensity-Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Functional Assessment of a Novel Children's Synbiotic
Status: COMPLETED
Conditions: Constipation|Signs and Symptoms|Digestive Signs and Symptoms|Infrequent or Difficult Evacuation
Interventions: DIETARY_SUPPLEMENT: PDS-08|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: ENERGI-F703 for Diabetic Foot Ulcers Phase II Study
Status: COMPLETED
Conditions: Diabetic Foot|Foot Ulcer|Diabetes Mellitus|Wounds
Interventions: DRUG: ENERGI-F703|DRUG: ENERGI-F703 matched vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Eustachian Tube Dysfunction (ETD) and Facial Pain With Combined Acoustic Vibration and Oscillating Expiratory Pressure
Status: RECRUITING
Conditions: Eustachian Tube Dysfunction|Facial Pain
Interventions: DEVICE: SinuSonic Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis
Status: UNKNOWN
Conditions: Halitosis
Interventions: DRUG: L. reuteri Prodentis® lozenges|OTHER: Placebo lozenges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Functional MRI Changes Resulting From the Feuerstein Program in Older People With Mild Cognitive Impairment (MCI)
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Feuerstein Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Electrical Stimulation of the Mandibular Nerve for Pain and Function Management in Temporomandibular Disorders
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Disorder
Interventions: PROCEDURE: Percutaneous nerve stimulation|OTHER: Manual therapy|OTHER: exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensified Treatment With Carfilzomib in Myeloma Patients Still PET-positive After First Line Treatment.
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Lenalidomide|DEVICE: PET-CT|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid for Craniofacial Surgery
Status: TERMINATED
Conditions: Craniosynostosis|Bleeding
Interventions: DRUG: Tranexamic acid|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Core Stability in Ataxic Cerebral Palsied Children
Status: COMPLETED
Conditions: Ataxic Cerebral Palsied Children|Core Stability|Balance and Coordination|Severity of the Ataxia
Interventions: OTHER: core stability training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II/III Study of Anti-VEGF in Neovascular AMD
Status: COMPLETED
Conditions: Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: EYE001 anti-VEGF aptamer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Pericapsular Nerve Group Block vs Femoral Nerve Block for Perioperative Pain Management in Patients With Hip Fracture.
Status: RECRUITING
Conditions: Pain
Interventions: PROCEDURE: PENG block|PROCEDURE: FN block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment Efficacy of a Modified Positive Airway Pressure Device to Treat Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: FPH Device with SensAwake On + Pressure Support A|DEVICE: FPH Device with SensAwake Off + Pressure Support A|DEVICE: FPH Device with SensAwake On + Pressure Support B|DEVICE: FPH Device with SensAwake Off + Pressure Support B|DEVICE: Competitor's PAP Released Device + Pressure Support A|DEVICE: Competitor's PAP Released Device + Pressure Support B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Efficacy & Safety of Aflibercept IVT for the Treatment of DME in Subjects Who Completed the VISTA-DME Trial
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aflibercept|PROCEDURE: Focal Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nose Selection Using Rhnoscope on Epistaxis of Nasotracheal Intubation
Status: COMPLETED
Conditions: Nasotracheal Intubation
Interventions: DIAGNOSTIC_TEST: rhinoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: GIS-SUSANTI-TNF-2015 (Anti-TNF Discontinuation )
Status: COMPLETED
Conditions: Crohn's Disease|Inflammatory Bowel Disease|Ulcerative Colitis
Interventions: BIOLOGICAL: Anti-TNF: Infliximab (Infusion)|DRUG: Anti-TNF discontinuation: Physiological saline solution|BIOLOGICAL: Anti-TNF:Adalimumab (Subcutaneus)|DRUG: Anti-TNF discontinuation: Physiological saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluations of Cardiopulmonary Function and Motor Development of Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease in Children|Infant Development|Infant Conditions|Motor Neuropathy|Motor Delay|Cardiopulmonary
Interventions: BEHAVIORAL: exercise-guidance on rehab APP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ruxolitinib Efficacy and Safety in Patients With HU Resistant or Intolerant Polycythemia Vera vs Best Available Therapy.
Status: COMPLETED
Conditions: Polycythemia Vera
Interventions: DRUG: Best Available Therapy|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Procedural Discomfort Related to Number of Intradetrusor Botox Injections
Status: RECRUITING
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: Intradetrusor Botox Injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate an Experimental Universal Influenza Vaccine, INFLUENZA G1 mHA, in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza Prevention
Interventions: BIOLOGICAL: INFLUENZA G1 mHA|BIOLOGICAL: Placebo|BIOLOGICAL: Al(OH)3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: DBT for Chronically Self-harming Individuals With BPD: Evaluating the Clinical & Cost Effectiveness of a 6 mo. Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Dialectical Behaviour Therapy-6 months|BEHAVIORAL: Dialectical Behaviour Therapy-12 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Using Two Different Suturing Techniques on Free Gingival Marginal Stability
Status: COMPLETED
Conditions: Altered Passive Eruption of Teeth
Interventions: PROCEDURE: esthetic crown leghthening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Bortezomib and Rituximab Plus Plasmapheresis in AMR
Status: RECRUITING
Conditions: Antibody-mediated Rejection
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Head and Neck Cancer|Lung Cancer|Ovarian Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cisplatin|DRUG: lurtotecan liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the Hydrus Aqueous Implant in Subjects With POAG
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma
Interventions: DRUG: prestudy topical glaucoma medications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Clonidine in Glycemia During Coronary Artery Bypass Graft With Cardiopulmonary By-pass
Status: COMPLETED
Conditions: Glycemia During Coronary Artery Bypass Graft|Sedation During Pre-anesthetic Medication
Interventions: DRUG: Clonidine|DRUG: Ringer lactato
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dasatinib and Lapatinib Ditolsylate in Treating Patients With Advanced Solid Tumors That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: dasatinib|DRUG: lapatinib ditosylate|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AGEN1884 Plus AGEN2034 Combined With Cisplatin-Gemcitabine for Muscle-Invasive Bladder Cancer
Status: TERMINATED
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: AGEN1884|DRUG: AGEN2034|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention to Improve HCV Treatment Uptake and Adherence in HIV/HCV Coinfection
Status: COMPLETED
Conditions: HIV|Hepatitis C|Co-Infection
Interventions: BEHAVIORAL: Prep-C|BEHAVIORAL: Educational Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rituximab, Pentostatin, Cyclophosphamide, and Lenalidomide in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: Rituximab|DRUG: Cyclophosphamide|DRUG: Lenalidomide|DRUG: Pentostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AX Versus AC as Adjuvant Treatment for Node-Negative Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Doxorubicin, Cyclophosphamide|DRUG: doxorubicin, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAT3221032: A Study to Evaluate the Effects of Switching From Cigarette Smoking to Using One of Five Variants of a Heated Tobacco Product on Biomarkers of Exposure and Biomarkers of Potential Harm in Healthy Subjects
Status: COMPLETED
Conditions: Smoking|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Product A: Non-Combusted Cigarette Variant 42001402 and product use Mode B|OTHER: Product B: Non-Combusted Cigarette Variant 42001399 and product use Mode B|OTHER: Product C: Non-Combusted Cigarette Variant 42001401 and product use Mode B|OTHER: Product D: Non-Combusted Cigarette Variant 40007386 and product use Mode B|OTHER: Product E: Non-Combusted Cigarette Variant 42001402 and product use Mode A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Sprint Stair Climbing "Snacks" on Markers of Metabolism and Vascular Function
Status: COMPLETED
Conditions: Physical Activity|Diet Modification
Interventions: BEHAVIORAL: High-Carbohydrate Sedentary|BEHAVIORAL: High-Carbohydrate Active|BEHAVIORAL: Low-carbohydrate Sedentary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Basal Cell
Interventions: DRUG: CX-4945
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of 200mg/5 mL Azithromycin Oral Suspension Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Azithromycin|DRUG: Zithromax®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Image Guided EVD Placement
Status: NOT_YET_RECRUITING
Conditions: External Ventricular Drain (EVD)|Image Guidance
Interventions: DEVICE: Image Guided External Ventricular Drain Placement Using the NAV3 System|PROCEDURE: Free Hand External Ventricular Drain Placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT