pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Analyzing Challenging Clinical Discussions in Orthopaedics
Status: TERMINATED
Conditions: Teach-Back Communication|Arthritis|Knee Osteoarthritis|Knee Arthropathy
Interventions: OTHER: Teach-Back Lesson
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular Carcinoma (HCC)
Status: TERMINATED
Conditions: Hepatocellular Carcinoma Non-resectable|Hepatocellular Carcinoma Recurrent|Carcinoma, Hepatocellular|Liver Diseases|Neoplasms by Histologic Type|Digestive System Neoplasms|Carcinoma|Liver Neoplasms|Neoplasms|Neoplasms by Site|Digestive System Diseases|Adenocarcinoma|Neoplasms, Glandular and Epithelial
Interventions: DRUG: ABT-869|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Bendamustine Hydrochloride, and Lenalidomide in Treating Patients With Aggressive B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: bendamustine hydrochloride|DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Salbutamol on Emotional and Cognitive Functions in Healthy Subjects
Status: COMPLETED
Conditions: Memory Functions
Interventions: DRUG: Salbutamol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety Evaluation of ECG Intervals and Blood Pressure in Normal Healthy Volunteers After Use of Nebivolol, Atenolol, Moxifloxacin, or Placebo
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol|DRUG: Atenolol|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Neuro-glio-epithelial Unit (NGEU) in Biopsies Taken During Peroral Endoscopic Myotomy (POEM) for Achalasia: a Feasibility and Safety Study.
Status: COMPLETED
Conditions: Esophageal Achalasia
Interventions: PROCEDURE: Esophageal biopsies during Peroral Endoscopic Myotomy (POEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline (KW-6002)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Fatigue, Self-Regulation, and Academic Performance: A Physiological Study
Status: RECRUITING
Conditions: Cognitive Fatigue|Mental Fatigue|Behavioral Performance|Heart Rate Variability|Skin Conductance|Academic Performance|Self-regulation
Interventions: OTHER: Baseline|OTHER: Fatigue Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Systemic Stress Prevention Via Application SysLife© for Companies
Status: COMPLETED
Conditions: Stress, Psychological|Stress, Systemic|Application
Interventions: BEHAVIORAL: SysLife©|BEHAVIORAL: SysLife©, as intervention after closing the RCT-design
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Golimumab in Chinese Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Placebo|DRUG: Golimumab|DRUG: Golimumab (placebo group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy Of SCH1 In The Treatment Of Acute Infectious Conjunctivitis
Status: COMPLETED
Conditions: Acute Infectious Conjunctivitis (Disorder)
Interventions: DRUG: SCH-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-Term Immunogenicity in Subjects Boosted With a TBE Vaccine for Adults
Status: COMPLETED
Conditions: Encephalitis, Tick-Borne
Interventions: BIOLOGICAL: Tick-Borne Encephalitis vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety in Nasolabial Fold After Rhytidectomy Using Non-absorbable Mesh
Status: COMPLETED
Conditions: Nasolabial Fold
Interventions: DEVICE: Non-absorbable polypropylene mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Consumer m-Health Services for User Engagement and Health Promotion: An Organizational Field Experiment
Status: COMPLETED
Conditions: Dietary Habits|Compliance Behavior
Interventions: BEHAVIORAL: Self-monitoring via Smartphone|BEHAVIORAL: Peer support via Smartphone|BEHAVIORAL: Professional support via Smartphone|BEHAVIORAL: Self-monitoring via Web (Static)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ferric Derisomaltose (Iron Isomaltoside) Versus Iron Sucrose for Treatment of Iron Deficiency in Pregnancy
Status: RECRUITING
Conditions: Iron Deficiency Anaemia in Childbirth
Interventions: DRUG: Iron Isomaltoside 1000, ferric derisomaltose|DRUG: Iron sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab plus TP|DRUG: TP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Effect and Associated Mechanisms of Mango Consumption
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight or Obesity|Healthy
Interventions: DIETARY_SUPPLEMENT: Mango|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Venetoclax With High-dose Ibrutinib for CLL Progressing on Single Agent Ibrutinib
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG)
Status: RECRUITING
Conditions: Anemia|Coronary Disease|Coronary Artery Disease|Coronary Stenosis|Coronary Occlusion|Systemic Inflammatory Response|Bleeding|Epigenetic Disorder
Interventions: DRUG: Erythropoietin|PROCEDURE: blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension
Status: RECRUITING
Conditions: Hypertension
Interventions: DRUG: Placebo|DRUG: lorundrostat Dose 1|DRUG: lorundrostat Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Trial Evaluating the Use of SR34006 in the Treatment of Deep Vein Thrombosis (DVT)
Status: COMPLETED
Conditions: Deep Vein Thrombosis
Interventions: DRUG: SanOrg34006|DRUG: LMW heparin|DRUG: Unfractionated heparin|DRUG: Vitamin K antagonist (VKA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Dose Received by the Prostate With in Vivo Dosimetry in Patients Treated With Daily IGRT Associated With IMRT Using Two Repositioning Techniques for Localized Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: OTHER: CBCT|OTHER: fiducial marker (kV imaging)|RADIATION: IGRT Associated With IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SCIO-469: Open-Label Study for Patients With Myelodysplastic Syndromes.
Status: COMPLETED
Conditions: Bone Marrow Diseases|Myelodysplastic Syndromes|Hematologic Diseases|Bone Marrow Neoplasms
Interventions: DRUG: SCIO-469|DRUG: SCIO-469|DRUG: SCIO-469|DRUG: SCIO-469
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "HerzCheck" - Detection of Early Heart Failure Using Telemedicine in Structurally Weak Regions
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: BEHAVIORAL: Prevention offer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Efficacy of PECS II Block Versus Axillary Ring Block in Rotator Cuff Repair Patients
Status: RECRUITING
Conditions: Shoulder Pain
Interventions: PROCEDURE: Nerve Block - either PECS II or axillary ring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Injection (CNCT19) in the Treatment of Cluster of Differentiation 19 (CD19) Positive Relapsed or Refractory B Cell Malignancies
Status: UNKNOWN
Conditions: Relapsed or Refractory Hematological Malignancies
Interventions: BIOLOGICAL: CNCT19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chalazion Conservative Treatment Trial
Status: COMPLETED
Conditions: Chalazion Unspecified Eye, Unspecified Eyelid|Chalazion Left Eye, Unspecified Eyelid|Chalazion Right Eye, Unspecified Eyelid|Chalazion Both Eyes
Interventions: DRUG: Hot Compress plus Tobramycin Drops and Ointment|DRUG: Hot compress plus Tobramycin/Dexamethasone Drops and Ointment|OTHER: Hot Compresses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study , Association of Cisplatine Topotecan and Cetuximab in Patients Whith Late or in Progress Epithelial Cancer of the Cervix
Status: TERMINATED
Conditions: Cervix Cancer
Interventions: DRUG: ERBITUX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
Status: COMPLETED
Conditions: Normal Healthy Volunteers Without Chronic Medical Conditions|Coronary Artery Disease|Cardiac Risk Factors|Myocardial Infarction
Interventions: DRUG: Slow Infusion of Rubidium-82|DRUG: Slow Infusion of Rubidium-82|DRUG: Slow Infusion of Rubidium-82
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK).
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: PEG- 400 based artificial tear|DRUG: Systane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Hyperthermic Intraperitoneal Chemotherapy|Hepatocellular Carcinoma|Ruptured Liver
Interventions: PROCEDURE: intraperitoneal hyperthermic perfusion chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: EUS-FNI for Nonfunctional Pancreatic Neuroendocrine Tumors
Status: RECRUITING
Conditions: Nonfunctional Pancreatic Neuroendocrine Tumor|Pancreatic Neuroendocrine Tumor|Endoscopic Ultrasound
Interventions: PROCEDURE: EUS-guided ethanol ablation|PROCEDURE: EUS-guided lauromacrogol ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup
Status: COMPLETED
Conditions: Bronchitis
Interventions: DRUG: 1.35 g SCMC- lys powder|DRUG: Fluifort® syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S-1 and and Gemcitabine vs Gemcitabine Alone as Adjuvant Chemotherapy for Patients With Resected Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: S-1, Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Temsirolimus in Patients With Advanced Malignancy
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Bevacizumab|DRUG: Temsirolimus|PROCEDURE: Additional Blood Drawn|PROCEDURE: Biopsy|PROCEDURE: DCE-MRI Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Hepatic Safety of EGCG
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DIETARY_SUPPLEMENT: Epigallocatechin gallate (EGCG)|DRUG: Clomiphene Citrate|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: sTMS for Substance Use-disordered Veterans
Status: COMPLETED
Conditions: Cocaine Addiction|Opioid Addiction|Alcohol Addiction
Interventions: DEVICE: sTMS|DEVICE: sham sTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: RAD001, FOLFOX and Bevacizumab in Treatment of Colorectal Carcinoma
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: RAD001|DRUG: FOLFOX|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin and Gemcitabine in Treating Patients With Locally Recurrent or Metastatic Unresectable Renal Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma|Renal Cell Carcinoma With Sarcomatoid Features
Interventions: DRUG: Doxorubicin|DRUG: Gemcitabine|DRUG: G-CSF (granulocyte-colony stimulating factor)|DRUG: Neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of Camrelizumab Combined With Apatinib and Hyperfractionated Radiotherapy for Renal Cell Carcinoma
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: COMBINATION_PRODUCT: camrelizumab+apatinib+hyperfractionated radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Genomic and Metabolomic Markers Reflecting the Complications of Hypercortisolism (CUSHINGOMICS)
Status: RECRUITING
Conditions: Adult Glucocorticoid Excess|Adult Adrenal Insufficiency
Interventions: BIOLOGICAL: Biological samples|OTHER: Complications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Survival of Patients With Primary Prophylactic ICD Indication
Status: COMPLETED
Conditions: Primary Prevention|Tachycardia, Ventricular|Sudden Cardiac Death
Interventions: OTHER: Intensified diagnostic and treatment measures following 1st appropriate ICD therapy|OTHER: Standard follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Self-selected or Predetermined Internet-based Treatment for Generalized Anxiety Disorder With Different Types of Support
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Self-selected treatment|BEHAVIORAL: Predetermined treatment|BEHAVIORAL: Weekly support|BEHAVIORAL: Support on demand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexamethasone Adjuvant in Combined Supraclavicular Block and Suprascapular Block Versus Interscalene Block in Patients Undergoing Shoulder Arthroscopy
Status: NOT_YET_RECRUITING
Conditions: Shoulder Arthroscopy Blocks|Dexamethasone
Interventions: PROCEDURE: Shoulder arthroscopy blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MPS (RaDiCo Cohort) (RaDiCo-MPS)
Status: RECRUITING
Conditions: Mucopolysaccharidosis I|Mucopolysaccharidosis II|Mucopolysaccharidosis III|Mucopolysaccharidosis IV|Mucopolysaccharidosis VI|Mucopolysaccharidosis VII|Mucopolysaccharidosis IX|Multiple Sulfatase Deficiency Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Denervation for Osteoarthritis in the PIP-joint Efficacy Study (DOPS)
Status: RECRUITING
Conditions: Osteoarthritis Finger|Surgery
Interventions: PROCEDURE: PIP joint denervation|PROCEDURE: Patient education plus exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eight Week Clinical Study to Investigate Reduction of Extrinsic Tooth Stain by Electric Toothbrush
Status: UNKNOWN
Conditions: Tooth Bleaching
Interventions: DEVICE: Oclean electric toothbrush A|DEVICE: Oral B manual toothbrush|DEVICE: Oclean electric toothbrush B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PARP Inhibitor BMN-673 and Temozolomide or Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Metastatic Cancer|Unspecified Adult Solid Tumor
Interventions: DRUG: PARP inhibitor BMN-673|DRUG: temozolomide|DRUG: irinotecan hydrochloride|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution of the Imaging to the Expression of intégrines αvβ3 for the Characterization of Residual Masses of Non-seminoma Tumors at the End of Chemotherapy
Status: COMPLETED
Conditions: Non-seminomatous Germ Cell Tumors|Metastasis
Interventions: OTHER: K5-RGD PET|OTHER: FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Pandemic Influenza Vaccine (GSK1562902A)|BIOLOGICAL: Fluarix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Women First: Preconception Maternal Nutrition
Status: COMPLETED
Conditions: Maternal Malnutrition|Growth Failure|Mortality|Morbidity|Stunting
Interventions: DIETARY_SUPPLEMENT: Comprehensive Maternal Nutrition Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan
Status: RECRUITING
Conditions: Prostate Cancer|Metastatic Castration-resistant Prostate Cancer|Metastatic Castration-resistant Prostate Carcinoma
Interventions: DRUG: 18F-DCFPyl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Fluzoparib Combined With Adjuvant Endocrine Therapy for HR+/HER2- SNF3-subtype Early Breast Cancer (BCTOP-L-A01)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Fluzoparib|DRUG: Anastrozole|DRUG: Letrozole|DRUG: Exemestane|DRUG: Tamoxifen|DRUG: Toremifene|DRUG: Abemaciclib|DRUG: LHRH agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficiency of a Cognitive Remedial Program (PROCOG-SEP) Designed for Multiple Sclerosis Patients
Status: UNKNOWN
Conditions: Cognitive Disorders|Multiple Sclerosis
Interventions: OTHER: procog|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Educating Nurses About Venous Thromboembolism (VTE) Prevention
Status: COMPLETED
Conditions: Venous Thromboembolism|Venous Thrombosis
Interventions: BEHAVIORAL: Nurse education in contemporary format|BEHAVIORAL: Nurse education in traditional format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Sibling Oocyte Study- Comparison of ZyMotTM Microfluidics Device to Density Gradient for Sperm Selection During ICSI
Status: COMPLETED
Conditions: ART
Interventions: DEVICE: ZyMot Multi Sperm Separation Device (850 ul)|OTHER: Density Gradient Centrifugation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Immunogenicity of the Sm-p80 + GLA-SE (SchistoShield®) Candidate Vaccine in Healthy Adults in Burkina Faso and Madagascar
Status: RECRUITING
Conditions: Schistosomiasis
Interventions: BIOLOGICAL: Sm-p80 + GLA-SE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Post-market Clinical Evaluation of St. Jude Medical™ MR Conditional ICD System on Patients Undergoing Magnetic Resonance Imaging
Status: COMPLETED
Conditions: ICD|Tachycardia
Interventions: RADIATION: Thoracic MRI Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nab-Paclitaxel and Cisplatin or Nab-paclitaxel as Induction Therapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck|Carcinoma, Squamous Cell of the Head and Neck|Cancer of Head and Neck|Cancer of the Head and Neck|Head and Neck Cancer|Neoplasms, Head and Neck
Interventions: DRUG: nab-Paclitaxel|DRUG: Cisplatin|BIOLOGICAL: Cetuximab|RADIATION: Intensity-Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Experimental Study on the Effect of Tenofovir Amibufenamide on Blood Lipid During Anti-HBV Treatment
Status: UNKNOWN
Conditions: Hepatitis B, Chronic|Lipid Disorder
Interventions: DRUG: oral Tenofovir Amibufenamide 25mg each day|DRUG: lipid lowering drugs (e.g. Atorvastatin and amlodipine.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose Stem Cell Assisted Skin Graft
Status: NOT_YET_RECRUITING
Conditions: Skin Graft
Interventions: PROCEDURE: autologous adipose stem cell injection|PROCEDURE: saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Comorbid Sleep Disorders and Post Traumatic Stress Disorder (PTSD)
Status: UNKNOWN
Conditions: Trauma|Insomnia|Nightmares
Interventions: BEHAVIORAL: Cognitive Processing Therapy-Cognitive Only (CPT)|BEHAVIORAL: Cognitive Behavioral Therapy of Insomnia and Nightmares (CBTin)|BEHAVIORAL: Continuation Cognitive Processing Therapy-Cognitive Only (CPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Antimetabolite Induction, High-Dose Alkylating Agent Consolidation and Retroviral Transduction of the MDR1 Gene Into Peripheral Blood Progenitor Cells Followed by Intensification Therapy With Sequential Paclitaxel and Doxorubicin for Stage 4 Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Neoplasm Metastasis
Interventions: GENETIC: peripheral blood progenitor cells carrying MDR1
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trial of Vemurafenib and Cobimetinib in Patients With Advanced BRAFV600 Mutant Melanoma
Status: WITHDRAWN
Conditions: Melanoma
Interventions: DRUG: Cobimetinib|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study in Healthy Participants to Assess the Effect of Rifampin on the Pharmacokinetics of JNJ-42847922
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-42847922|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot
Status: RECRUITING
Conditions: Epilepsy|Lennox-Gastaut Syndrome, Intractable
Interventions: DEVICE: Deep brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effectiveness of a Treatment With the Robot - Assisted Gait Training System Walkbot in Patients With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Assisted gait training with Walkbot System|OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taxotere + Cisplatin in Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Simvastatin to Treat Generalized Vitiligo
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Technique for Uretero-ileal Anastomosis for Patient With Bladder Cancer Who Are Suitable for Orthotopic Neobladder
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: PROCEDURE: uretero ileal anastomosis in single trough
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy Without Psychosocial Stress
Status: UNKNOWN
Conditions: Depressive Symptoms|Anxiety Disorders and Symptoms|Depression, Postpartum
Interventions: BEHAVIORAL: Mom´s Supporting Mom|BEHAVIORAL: Enhanced Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Itopride 150mg Once a Day Versus Itopride 50 mg Thrice a Day; in Patients With Functional Dyspepsia
Status: RECRUITING
Conditions: Functional Dyspepsia
Interventions: DRUG: Itopride Hydrochloride 150 mg extended release tablets|DRUG: Itopride Hydrochloride 50 mg film coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CBP-4888 in Healthy, Non-Pregnant Female Subjects
Status: RECRUITING
Conditions: Healthy Volunteer Study
Interventions: DRUG: CBP-4888|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Fields in Neonatology: Exposure and Impact on the Nervous System
Status: RECRUITING
Conditions: Preterm Newborn
Interventions: OTHER: questionary|OTHER: Daily continuous recording of radiofrequency exposure levels|OTHER: Follow-up of daily infants clinical parameters|OTHER: recording of cerebral (EEG)|OTHER: autonomic nervous (ECG) activity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH
Status: COMPLETED
Conditions: Conscious Sedation
Interventions: DRUG: Magnesium sulphate|DRUG: Fentanyl|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterisation of the Nasal Microbiome in Patients With N-ERD
Status: COMPLETED
Conditions: Aspirin Exacerbated Respiratory Disease|Chronic Rhinitis
Interventions: OTHER: Microbiome swabs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Hypoglycemia Following Gastric Bypass Surgery
Status: COMPLETED
Conditions: Hypoglycemia|Obesity|Surgery
Interventions: DRUG: Glucobay (acarbose)|DRUG: Januvia (sitagliptin)|DRUG: Verapamil HEXAL (verapamil)|DRUG: Victoza (liraglutide)|DRUG: Signifor (pasireotide)|DEVICE: Continuous glucose monitoring (CGM)|DIETARY_SUPPLEMENT: Meal tolerance test (MTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Trial of Sertraline, Cognitive Behaviour Therapy & Combined Therapy for Postnatal Depression
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: DRUG: Sertraline|BEHAVIORAL: Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Tibial Nerve Stimulation Versus Pelvic Floor Exercises for Treatment of Overactive Bladder
Status: UNKNOWN
Conditions: Urge Incontinence
Interventions: OTHER: "Tibial stimulation" and "pelvic floor exercises"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Part 2 on the Study Prevalence of SARS -Cov2 Carriage in Asymptomatic and Mildly-symptomatic Children (COVILLE2) (WHO)
Status: WITHDRAWN
Conditions: COVID19
Interventions: DIAGNOSTIC_TEST: RT-PCR SARS-Cov2|DIAGNOSTIC_TEST: Sars-Cov2 serology
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Single Ascending Doses of PF-07258669 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: PF-07258669|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: GNB4 and Riplet Gene Methylation Combined Detection Kit (Fluorescence PCR Method)
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DIAGNOSTIC_TEST: GNB4 and Riplet Gene Methylation Combined Detection Kit (Fluorescent PCR Method)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of a Chewing Gum Containing POs-Ca and Fluoride on Enamel
Status: COMPLETED
Conditions: Enamel Subsurface Lesion
Interventions: DIETARY_SUPPLEMENT: chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Combination of Water Aerobics and Metacognitive Training
Status: RECRUITING
Conditions: Psychosis
Interventions: BEHAVIORAL: Water aerobics|BEHAVIORAL: Metacognitive Training (MCT)|BEHAVIORAL: Combined intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Radiation Therapy in Treating Patients With Locally Advanced Upper Gastrointestinal Cancer
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Gastric Cancer|Pancreatic Cancer|Small Intestine Cancer
Interventions: DRUG: gemcitabine hydrochloride|GENETIC: polymerase chain reaction|OTHER: immunohistochemistry staining method|PROCEDURE: conventional surgery|RADIATION: intraoperative radiation therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Etoricoxib in Acute Ankle Sprain: A Double-Blind Comparative Study Among 2 Treatments Protocols
Status: UNKNOWN
Conditions: Sprains and Strains|Contusions
Interventions: DRUG: etoricoxib 90mg 14 days|DRUG: etoricoxib 60mg daily for 14 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genetics of Wilms' Tumor and/or the Associated Conditions of Aniridia, Hemihypertrophy, and Genitourinary Anomalies
Status: UNKNOWN
Conditions: Wilms' Tumor|Aniridia
Interventions: BEHAVIORAL: Questionnaire|OTHER: Blood specimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nasogastric Versus Orogastric Route of Feeding in Preterm (<32 Weeks) Neonates
Status: COMPLETED
Conditions: Apnea Prematurity
Interventions: PROCEDURE: feeding tube insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Percutaneous Transforaminal Endoscopic Discectomy vs. Open Microdiscectomy for Lumbar Disc Herniation (PTED-study)
Status: UNKNOWN
Conditions: Lumbar Disk Herniation
Interventions: PROCEDURE: Transforaminal Endoscopic Discectomy|PROCEDURE: Open Microdiscectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of UCAD for Diagnosing Benign or Malignant Biliary Obstruction and Follow-up
Status: UNKNOWN
Conditions: Biliary Tract Neoplasms|Pancreatic Carcinoma|Gallbladder Cancer|Pancreatic Head Carcinoma
Interventions: DIAGNOSTIC_TEST: The level of CIN
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study to Evaluate the Pharmacokinetics, Safety and Tolerability of CKD-388 in Healthy Subjects
Status: UNKNOWN
Conditions: Chronic Hepatitis b
Interventions: DRUG: D418 Tab.|DRUG: CKD-388 Tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Aerobic Training for People Receiving Chemotherapy for Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Breast Carcinoma
Interventions: BEHAVIORAL: Adaptive Aerobic Training/AT Dosing|BEHAVIORAL: Standard (fixed) Aerobic Training/AT dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph II of Non-myeloablative Allogeneic Transplantation Using TLI & ATG In Patients w/ Cutaneous T Cell Lymphoma
Status: COMPLETED
Conditions: Mycoses|Sezary Syndrome|Lymphoma, T-Cell, Cutaneous|Bone Marrow Transplant Failure|Lymphoma, Non-Hodgkin|Cutaneous T-cell Lymphoma
Interventions: DRUG: anti-thymocyte globulin|DRUG: cyclosporine|RADIATION: Lymphoid radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Histological Change of The Dentinal-Pulp Complex and Root Resorption
Status: COMPLETED
Conditions: Laser|Intrusion|Histology|Resorption
Interventions: RADIATION: Low power laser in teeth after intrusive movement|OTHER: Simulated laser in teeth with intrusive movements
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Recombinant Human IL-4 Receptor Used in Treatment of Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Recombinant human soluble IL-4 receptor|BIOLOGICAL: Placebo for Recombinant human soluble IL-4 receptor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa and Interleukin-6 in Treating Patients With Recurrent Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: recombinant interferon-α|BIOLOGICAL: recombinant interleukin-6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nocturnal PtcCO2 Monitoring in Patients With Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: PtcCO2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF Pilot
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Strengthened Anticipatory Guidance Used in the MOH Malaysia Infant Oral Health Care Programme
Status: NOT_YET_RECRUITING
Conditions: Early Childhood Caries|Knowledge, Attitudes, Practice
Interventions: OTHER: Oral health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy, Safety, and Pharmacokinetic of MSC2156119J in Asian Participants With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Tepotinib 300 mg|DRUG: Tepotinib 500 mg|DRUG: Tepotinib 1000 mg|DRUG: Tepotinib|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diet for the Maintenance of Weight Loss and Metabolic Health in Obese Postmenopausal Women
Status: UNKNOWN
Conditions: Metabolic Syndrome|Diet Modification|Postmenopause
Interventions: OTHER: the MED|OTHER: the DASH|OTHER: Control diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability of Single Doses Oral CNDO 201 Trichuris Suis Ova in Patients With Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Trichuris suis ova|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Solid Tumors
Status: TERMINATED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: recombinant fowlpox-B7.1 vaccine|BIOLOGICAL: recombinant fowlpox-TRICOM vaccine|OTHER: laboratory biomarker analysis|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: daily TDF/FTC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Rollover Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: Alectinib|DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-interventional Substudy of ALX-HPP-502 to Assess Natural History of Patients With Juvenile-onset HPP Who Served as Historical Controls in ENB-006-09
Status: COMPLETED
Conditions: Hypophosphatasia|Bone Disease
Interventions: BIOLOGICAL: Retrospective Case Only
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multiple Dose Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ABT-288 in Stable Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ABT-288|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation
Status: RECRUITING
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial With Humanized TNFα Monoclonal Antibody Injection by Single Dose and Dose Escalation in Healthy Subjects
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Humanized TNFα monoclonal antibody|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Partial Breast Radiation Therapy in Treating Women Undergoing Breast-Conserving Therapy for Early Stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: adjuvant therapy|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimization of PEEP During Laparoscopic Surgery
Status: COMPLETED
Conditions: Post-Op Complication|Ventilator-Induced Lung Injury
Interventions: DIAGNOSTIC_TEST: Respiratory monitoring|DIAGNOSTIC_TEST: Capnography|DIAGNOSTIC_TEST: Arterial blood gas|DEVICE: Esophageal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Patient Satisfaction in Post-operative Breast Surgery Patients Having Physical Clinic and Tele Clinic Follow up: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Satisfaction, Patient|Satisfaction
Interventions: OTHER: Teleclinic|OTHER: Physical Clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Descriptive, Prospective, Non-interventional Study (NIS) to Describe Mirena and Amenorrhea Related Acceptability in Contraception Indication in Medical Practice
Status: COMPLETED
Conditions: Female Contraception
Interventions: DRUG: Levonorgestrel IUD (Mirena, BAY86-5028)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Healthy Volunteer Study to Evaluate the Impact of Various Common Interventions on Venous Pressure Signal Captured by PIVA
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DEVICE: Peripheral intravenous analysis (PIVA) algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Assessment of Arrhythmic BuRdEn With Post-ProCedural COntinuous ElectRocarDiographic Monitoring in Patients Undergoing Transcatheter Aortic Valve Implantation: The RECORD Study
Status: ACTIVE_NOT_RECRUITING
Conditions: TAVI|ECG Monitoring
Interventions: DEVICE: Cardiostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory Follicular Lymphoma
Interventions: BIOLOGICAL: Axicabtagene Ciloleucel|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Lenalidomide|DRUG: Rituximab|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
Status: COMPLETED
Conditions: Anxiety Disorders|Anxiety|Tobacco Dependence|Smoking, Cigarette|Smoking, Tobacco
Interventions: BEHAVIORAL: Personalized Feedback Intervention|BEHAVIORAL: Smoking Information Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT