pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Translational PKPD Modeling of Anti-infective Drugs Used in Pediatric Units.
Status: ACTIVE_NOT_RECRUITING
Conditions: Population Modeling of Anti-infective Drugs
Interventions: DRUG: Patients requiring cefotaxime treatment|DRUG: Patients requiring meropenem treatment|DRUG: Patients requiring fluconazole treatment|DRUG: Patients requiring isavuconazole treatment|DRUG: Patients requiring anidulafungin treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Conventional Impressions, Intraoral Scanners and Digital Photogrammetry for Full-arch Implant Prosthesis.
Status: RECRUITING
Conditions: Dental Implant Failed
Interventions: OTHER: Implant impression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Microfracture Technique for Talar Articular Cartilage Lesions With or Without Lateral Ligament Repairment
Status: UNKNOWN
Conditions: Lateral Ligament Repair|Talar Cartilage Lesion|Microfracture
Interventions: PROCEDURE: without lateral ligament repairment|PROCEDURE: lateral ligament repairment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing NicoBloc to Nicotine Lozenges
Status: COMPLETED
Conditions: Smoking Cessation|Nicotine Dependence
Interventions: DRUG: NicoBloc|DRUG: Nicotine Lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Muscadine Plus Grape Skin Extract|DRUG: Low-dose MPX|DRUG: High-dose MPX|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Blood Flow Restriction Training on Glycemic Control Among Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Low-intensity training combined with blood flow restriction (LI-BFR)|BEHAVIORAL: High-intensity aerobic exercise (HI)|BEHAVIORAL: Low intensity exercise (LI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I, The Study to Evaluate the Safety, Immunogenicity and Efficacy of YS-HBV-002
Status: NOT_YET_RECRUITING
Conditions: Chronic Hepatitis b
Interventions: BIOLOGICAL: YS-HBV-002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Posterior Capsule Opacification Study
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Square edge PMMA IOL|DEVICE: Round edge PMMA IOL|DEVICE: Acrysof IOL|DEVICE: square Edge PMMA IOL|DEVICE: Square Edge PMMA IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Tolerability and Pharmacokinetics of APX001 Administered by Intravenous Infusion to Healthy Subjects
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: APX001 single dose 1|DRUG: APX001 single dose 2|DRUG: APX001 single dose 3|DRUG: APX001 single dose 4|DRUG: APX001 single dose 5|DRUG: APX001 single dose 6|DRUG: APX001 multiple dose 1|DRUG: APX001 multiple dose 2|DRUG: APX001 multiple dose 3|DRUG: APX001 multiple dose 4|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Active and Placebo Controlled Study to Test the Efficacy and Safety of an Aspirin-Lidocaine Lozenge in the Symptomatic Treatment of Sore Throat Associated With a Common Cold
Status: COMPLETED
Conditions: Common Cold|Pharyngitis|Tonsillitis
Interventions: DRUG: Acetylsalicylic acid (Aspirin, BAYE4465) & Lidocain|DRUG: Acetylsalicylic Acid (Aspirin, BAYE4465)|DRUG: Lidocain|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Hemodialysis on Plasma Carnitine Levels in Patients With End Stage Renal Disease
Status: COMPLETED
Conditions: Hemodialysis Complication
Interventions: DRUG: L-Carnitine 500Mg thrice daily|DRUG: 1g L-Carnitine IV three times a week
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Iron and Vitamin Supplementation in Hip/Knee Surgery
Status: COMPLETED
Conditions: Orthopedic Disorder|Hip Arthropathy|Knee Arthropathy|Anemia|Iron Poor Blood
Interventions: DIETARY_SUPPLEMENT: Iron plus folic acid, vitamin B2, B6, B12, C, and E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of a Combination of Conservative Treatments Compared to Isometric Exercise on Clinical Outcomes in Patients With Cervical Radiculopathy
Status: NOT_YET_RECRUITING
Conditions: Cervical Radiculopathy
Interventions: PROCEDURE: 1.Isometric exercise 2.combined conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Glycaemic Control With L-carnitine
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: L-carnitine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Icodextrin Study to Test Short-Term Safety, Tolerability and Preliminary Efficacy of Sodium-Free Solution in PD Patients
Status: COMPLETED
Conditions: Chronic Kidney Failure
Interventions: DRUG: Icodextrin/Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Use of DIOVAN to Reduce Post-Cardioversion Recurrence of Atrial Fibrillation Trial (the DRAFT Trial)
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: My Lifestyle Intervention of Food and Exercise
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Tailored Lifestyle Intervention (TLI)|BEHAVIORAL: Commercial Weight Loss Program (CWLP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Efficacy, Tolerability and Safety of Different Budesonide Oral Gel Doses in Adults' Subjects of Both Genders With Eosinophilic Esophagitis (EoE)
Status: WITHDRAWN
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Budesonide Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dulce Digital-Me: An Adaptive mHealth Intervention for Underserved Hispanics With Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Dulce Digital|BEHAVIORAL: Dulce Digital-Me (Automated Delivery)|BEHAVIORAL: Dulce Digital-Me (Medical Assistant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peanut Oral Immunotherapy in Children With Peanut Allergy (Peanut Flour)
Status: COMPLETED
Conditions: Peanut Allergic Subjects
Interventions: BIOLOGICAL: Peanut Oral Immunotherapy (POIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Echocardiography to Identify Chemotherapy Induced Cardiotoxicity in Cancer Patients With Heart Failure Risk
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Echocardiography|OTHER: Electronic Health Record Review|OTHER: Questionnaire Administration|PROCEDURE: Stress Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: HIF-2 Alpha Inhibitor PT2385 in Treating Patients With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Recurrent Glioblastoma
Interventions: DRUG: HIF-2alpha Inhibitor PT2385|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacogenomic Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Changing to DUOTRAV® From Prior Therapy
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension|Pigment Dispersion Glaucoma
Interventions: DRUG: Travoprost 0.004%+Timolol 0.5% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed Dose Study Evaluating the Efficacy and Safety of Orvepitant in Subjects With Major Depressive Disorder
Status: TERMINATED
Conditions: Depressive Disorder, Major
Interventions: DRUG: orvepitant|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia
Status: UNKNOWN
Conditions: Hyperglycemia
Interventions: DRUG: Berberine; Insulin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preference for Clarinex Tablets vs. Zyrtec Tablets in Patients With Allergies (P03182)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis|Perennial Allergic Rhinitis
Interventions: DRUG: Desloratadine 5 mg (Clarinex)|DRUG: Cetirizine (Zyrtec)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Opioid Sparing General Venous Anesthesia With Magnesium Sulfate
Status: COMPLETED
Conditions: Magnesium Sulfate|Postoperative Pain|Opioid Use
Interventions: DRUG: Remifentanil group|DRUG: Magnesium sulfate group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Measurement of Blood Coagulation
Status: UNKNOWN
Conditions: Anticoagulants; Increased|Anticoagulant Overdosage|Coagulation Disorder|Blood Clot|Blood Coagulation Disorder
Interventions: DEVICE: Measurement of coagulability of blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase Deficiency
Status: TERMINATED
Conditions: Mevalonic Aciduria|Mevalonate Kinase Deficiency|Immune System Diseases|Periodic Fever Syndromes, Hereditary|Lipid Metabolism, Inborn Errors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Of SY-3505 Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: SY-3505 Capsules|DRUG: Crizotinib Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing the Pharmacodynamics and Pharmacokinetics of BC Combo THDB0207 and Lantus® and Humalog® in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Euglycemic clamp with BC Combo THDB0207|DRUG: Euglycemic clamp with Lantus®|DRUG: Euglycemic clamp with Humalog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Immunotherapy of Hematological Malignancies Using Regulatory T-cell Selective Depletion
Status: NOT_YET_RECRUITING
Conditions: Hematological Malignancies|Regulatory T Cell Depletion|Relapse
Interventions: DRUG: T-reg depleted DLI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3
Status: COMPLETED
Conditions: Shigella Infection
Interventions: OTHER: Placebo|BIOLOGICAL: WRSs2|BIOLOGICAL: WRSs3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location
Status: RECRUITING
Conditions: Abortion
Interventions: DRUG: Mifepristone plus one dose Misoprostol|DRUG: Mifepristone plus two doses Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Are Text Message Reminders an Effective Intervention for Improving the Uptake of Breast Screening?
Status: COMPLETED
Conditions: Breast Screening
Interventions: OTHER: Text Message Reminder for Breast Screening Appointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Potential Benefits of Sleeve Gastrectomy Surgery on Diabetic Gastroparesis Symptoms
Status: WITHDRAWN
Conditions: Weight Loss|Diabetic Gastroparesis|Bariatric Surgery Candidate|Sleeve Gastrectomy|Gastric Emptying
Interventions: OTHER: Gastroparesis Cardinal Symptom Index Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Phase III Trial With Mepitel Film for the Prophylaxis of Radiation Dermatitis in Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Radiation Dermatitis
Interventions: DEVICE: Mepitel Film
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety, Efficacy and Changes in Induced Sputum and Blood Biomarkers Following Daily Repeat Doses of Inhaled GSK2269557 in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Acute Exacerbation
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK2269557|DRUG: Placebo|DEVICE: DISKUS|DEVICE: ELLIPTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia and Partial Mastectomy
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: PROCEDURE: PECS II|PROCEDURE: Local anesthetic infiltration|PROCEDURE: Subcutaneus local anesthetic infiltration|DRUG: Ropivacaine|DEVICE: bk medical Flex Focus 500 Ultrasound Machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Economic and Functional Impact of Peri-Operative Bracing for Primary Total Knee Arthroplasty (TKA)
Status: TERMINATED
Conditions: Arthropathy of Knee
Interventions: DEVICE: OCSI Rehabilitator brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN
Status: COMPLETED
Conditions: Myocardial Infarction|Inflammation
Interventions: DEVICE: Ferumoxytol enhanced MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of GH and Lirglutide on AgRP
Status: RECRUITING
Conditions: Healthy|Growth Hormone Deficiency
Interventions: DRUG: growth hormone and lirglutide|DRUG: growth hormone|DRUG: liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Phase II Clinical Study of Fruquintinib Combined With RC48 in the Treatment of Previously Treated HER2-positive Locally Advanced or Metastatic Gastric or Gastroesophageal Junction (G/GEJ) Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Fruquintinib + RC48
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXERT: Exercise Physiology After Thrombosis
Status: UNKNOWN
Conditions: Venous Thrombosis Deep (Limbs)|Post Thrombotic Syndrome
Interventions: DIAGNOSTIC_TEST: Cardiopulmonary exercise test (CPET)|DIAGNOSTIC_TEST: Exercise cardiac MRI|OTHER: 6 minute walk test|DIAGNOSTIC_TEST: Blood tests|OTHER: Quality of life questionnaires|OTHER: Repeat baseline assessments|DIAGNOSTIC_TEST: MR venogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Low Protein Diet on Top of Dapagliflozin on Chronic Kidney Disease in Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin 10 mg Tab|BEHAVIORAL: Low protein diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loperamide Grapefruit Juice Interaction PK Trial
Status: COMPLETED
Conditions: Drug Interaction
Interventions: DRUG: Loperamide / Red Grapefruit Juice|DRUG: Loperamide/ White Grapefruit Juice|DRUG: Loperamide / Pink Grapefruit Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimal Haloperidol Dose for Postoperative Nausea and Vomiting Prevention in High-risk Patients
Status: COMPLETED
Conditions: Gynecological Disease
Interventions: DRUG: Dexamethasone iv injection|DRUG: Dexamethasone, haloperidol|DRUG: Dexamethasone, haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Repeated exposure to acute Intermittent Hypoxia (rAIH)|OTHER: Normal Room Air|OTHER: Upper-limb Training by Research Staff|OTHER: Lower-limb Training by Research Staff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Prospective Observational Study to Characterize Patients Treated at Internal Medicine Clinics
Status: RECRUITING
Conditions: Respiratory Disease|Cardiovascular Diseases|Infectious Disease|Critical Illness|Immunological Disease|Pregnancy Disease|Metabolic Syndrome|Chronic Disease
Interventions: OTHER: Inpatient or Outpatient visit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: International Study to Predict Optimised Treatment in Attention Deficit/Hyperactivity Disorder
Status: UNKNOWN
Conditions: Attention Deficit/Hyperactivity Disorder
Interventions: DRUG: Short Acting Methylphenidate|DRUG: Long Acting Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Of 6-Month Duration To Evaluate The Weight Loss Effect Of Various Doses Of CP-945,598 In Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: CP-945,598|DRUG: sibutramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PET Imaging of the Translocator Proteine Ligands (TSPO) With [18 F] DPA-714 Biomarker of NeuroInflammation in Cognitive Decline (NIDECO)
Status: COMPLETED
Conditions: Memory Complaint|Mild Cognitive Impairment|Alzheimer Disease
Interventions: DRUG: [18F]DPA-714 PET/ [18F]AV-45 PET/neuropsychological assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multinational Trial of the Efficacy of Albendazole Against Soil-transmitted Nematode Infections in Children
Status: COMPLETED
Conditions: Infections With Soil-Transmitted Helminths (STH)
Interventions: DRUG: Albendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study With Lu AF20513 in Patients With Mild Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI) Due to AD
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: Lu AF20513|BIOLOGICAL: booster vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of tDCS on Social Cognition in Aging
Status: COMPLETED
Conditions: Aging|Social Cognition
Interventions: BEHAVIORAL: Social Cognition Task|DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Energy Shots and Caffeine for Energy and Wakefulness Levels
Status: COMPLETED
Conditions: Focus: to Compare a Commercially Available Energy Drink, B Vitamins, Caffeine Alone, and Placebo for Effectiveness on Perceived Energy Level and Wakefulness
Interventions: OTHER: Regular "5-hour Energy"|OTHER: Decaf "5-hour Energy"|OTHER: Compounded concentrated caffeine liquid|OTHER: Flavored bottled water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Chemotherapy in Treating Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: epirubicin hydrochloride|DRUG: fluorouracil|DRUG: goserelin acetate|DRUG: tamoxifen citrate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Bisphosphonate in Stress Fracture Treatment -A Randomised Controlled Double Blinded Multicenter Trial
Status: TERMINATED
Conditions: Stress Fracture Foot|Stress Fracture Ankle
Interventions: DRUG: Zoledronic Acid Injectable Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Intranasal Dexmedetomidine in Pediatric Patients With Congenital Heart Disease
Status: TERMINATED
Conditions: Dexmedetomidine|Congenital Heart Disease
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Comparative Study of Intrathecal Magnesium Sulphate & Midazolam With Epidural Ropivacaine for Caesarean Patients
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: intrathecal magnesium sulphate,|DRUG: Intrathecal midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial of Recruitment Strategies for Research Participation
Status: COMPLETED
Conditions: This Study Will Focus on Recruitment Strategies and Attitudes Towards Research Among Patients Considering Participation in 2 Parent Randomized Controlled Trials|Cancer|Research Ethics
Interventions: BEHAVIORAL: High-level recruitment strategy consent form|BEHAVIORAL: Mid-level recruitment strategy consent form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Candonilimab Plus Bevacizumab for Patients With Advanced HCC Who Progressed on A+T
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Candonilimab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engage 24: Evaluation of the Safety and Effectiveness of URG101 in Subjects With Interstitial Cystitis/Bladder Pain Syndrome
Status: TERMINATED
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: DRUG: URG101|DRUG: Placebo|DRUG: Lidocaine|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement.
Status: COMPLETED
Conditions: Knee Osteoarthritis|Blood Clot|Transfusion Related Complication|Blood Loss
Interventions: DRUG: Oral Tranexamic Acid|DRUG: Oral Aminocaproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Predictive Factors Associated to Bile Cultures and Antibiogram Resistance in Patients With Laparoscopic Cholecystectomy
Status: NOT_YET_RECRUITING
Conditions: Biliary Infection|Antibiotic Resistant Strain
Interventions: DIAGNOSTIC_TEST: Bile culture and phenotypic antibiogram resistance test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Advancing Health Equity by Integrating Social-Clinical Models During Pregnancy
Status: RECRUITING
Conditions: Cardiovascular Diseases|Obesity, Maternal|Diabetes
Interventions: BEHAVIORAL: WIC Referral|BEHAVIORAL: RDN Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Photobiomodulation in Post Menopause Genitourinary Syndrome
Status: UNKNOWN
Conditions: Postmenopausal Symptoms
Interventions: RADIATION: Photobiomodulation|RADIATION: Placebo Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TMC435-TiDP16-C125 - Study in Healthy Volunteers to Evaluate the Potential of TMC435 to Increase the Sensitivity of the Skin Towards Exposure to Sun Light
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: TMC435|DRUG: Placebo|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Intermittent and Continuous Enteral Feeding on Glucose-Insulin Dynamics in Critically Ill Medical Patients
Status: COMPLETED
Conditions: Glucose-insulin Dynamics
Interventions: OTHER: Comparison of the Effects of Intermittent and Continuous Enteral Feeding on Glucose-Insulin Dynamics in Critically Ill Medical Patients|DIETARY_SUPPLEMENT: Osmolite 1.2 cal/ml Enteral Feeds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder
Status: COMPLETED
Conditions: Anxiety Disorders|Somatoform Disorders
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Efficacy and Safety of Ergoferon in the Treatment of Viral Intestinal Infections in Children
Status: COMPLETED
Conditions: Viral Intestinal Infection
Interventions: DRUG: Ergoferon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Change Cycle Intervention for Improving Quality of Life in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Coping Class|BEHAVIORAL: Standard of Care|BEHAVIORAL: FACT-B Quality of Life
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Describe the Safety Profile and Compare the Immune Response of 4 Different Formulations of an Investigational Tdap Vaccine When Compared to Licensed Tdap Vaccine in Young Adults in Canada
Status: COMPLETED
Conditions: Tetanus Immunisation (Healthy Volunteers)|Diphtheria Immunisation (Healthy Volunteers)|Pertussis Immunisation (Healthy Volunteers)
Interventions: BIOLOGICAL: Investigational Tdap vaccine Formulation B|BIOLOGICAL: Investigational Tdap vaccine Formulation C|BIOLOGICAL: Investigational Tdap vaccine Formulation A|BIOLOGICAL: Investigational Tdap vaccine Formulation D|BIOLOGICAL: Licensed Tdap vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Head Elevation by a Bed on Sleep-disordered Breathing
Status: UNKNOWN
Conditions: Sleep-disordered Breathing|Obstructive Sleep Apnea
Interventions: PROCEDURE: Head elevation by an automatic adjustable bed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HoLEP vs BPRP of a Large Volume BPH: a Randomised Controlled Trial
Status: COMPLETED
Conditions: BPH With Urinary Obstruction|Male
Interventions: PROCEDURE: holmium laser enucleation of the prostate|PROCEDURE: Bipolar resection of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on OMT-28 in Maintenance of Sinus Rhythm in Patients With Persistent Atrial Fibrillation (AF)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: OMT-28|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation, Combination Chemotherapy Safety Study of Birinapant (TL32711), in Subjects With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Birinapant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resveratrol in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: oral resveratrol|DRUG: oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cryoballoon Ablation as First Line Treatment of Atrial Flutter
Status: COMPLETED
Conditions: Atrial Flutter Typical
Interventions: PROCEDURE: Radiofrequency ablation of CTI|PROCEDURE: Cryoballoon PVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postmarketing Study to Determine Performance of the SIGMA HP® PARTIAL KNEE SYSTEM
Status: COMPLETED
Conditions: Osteoarthritis|Post-traumatic Arthritis|Gout|Pseudo-gout
Interventions: DEVICE: SIGMA HP PARTIAL KNEE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroke Research Consortium in Northern Bavaria (STAMINA)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: thrombolysis therapy|PROCEDURE: endovascular therapy|PROCEDURE: decompressive surgery|DIAGNOSTIC_TEST: multimodal imaging in acute ischemic stroke|PROCEDURE: transfer of acute stroke patients to tertiary stroke centers|DRUG: initiation of antiplatelets, oral anticoagulation and lipid lowering drugs for secondary prevention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase I Study to Assess the Safety, Tolerability and PK of Ceftazidime-Avibactam in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CAZ-AVI|DRUG: 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Spasticity, Muscle|Spastic Paraplegia|Spastic Quadriplegia|Spastic Tetraplegia|Paraplegia|Tetraplegia
Interventions: DEVICE: Extracorporeal Shockwave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplementation and Cognitive Functions in the Elderly
Status: NOT_YET_RECRUITING
Conditions: Cognitive Impairment|Old Age; Debility
Interventions: DIETARY_SUPPLEMENT: Dietary supplement with micronised diosmin, hesperidin and herbal extracts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of SAHA & Tamoxifen for Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: suberoylanilide hydroxamic acid (SAHA, Vorinostat)|DRUG: tamoxifen citrate (Tamoxifen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Assess the Safety and Efficacy of Alefacept in de Novo Kidney Transplant Recipients
Status: TERMINATED
Conditions: Transplant; Failure, Kidney
Interventions: DRUG: Alefacept (ASP0485)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robustness and Usability of the Dreem 3 System for at Home Sleep Monitoring in an Insomnia Population.
Status: COMPLETED
Conditions: Insomnia, Secondary|Sleep Disturbance|Sleep|Sleep Initiation and Maintenance Disorders
Interventions: DEVICE: Dreem 3 System vs WatchPAT One|OTHER: Usability Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Carbon Dioxide Guided Angiography in Endovascular Abdominal Aortic Aneurysm Repair
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Carbon Dioxide Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of Artificial Tears on the Response to the Latanoprost Punctal Plug Delivery System in Subjects With Ocular Hypertension or Open-Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Latanoprost punctal plug|DRUG: artificial tears preserved with Benzalkonium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levels of the Stat4 Alpha and Stat4 Beta Isoforms in PBMCs From Patients With Crohn's Disease and Ulcerative Colitis
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Crohn's Disease|Ulcerative Colitis
Interventions: OTHER: measurement of inflammatory markers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Intelligent Customer-driven Solution for Children and Their Parents Undergoing Day Surgery
Status: COMPLETED
Conditions: Tonsillitis|Herniorrhaphies|Surgery|Children|Parents
Interventions: DEVICE: IcorySolution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation
Status: COMPLETED
Conditions: Venous Disease|Venous Vascular Diseases and Syndromes|Venous Insufficiency|Venous Ulcers
Interventions: PROCEDURE: Cryotherapy: Cooling gel wrap|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Oral STAT3 Inhibitor, TTI-101, in Patients With Advanced Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Head and Neck Squamous Cell Carcinoma|Non Small Cell Lung Cancer|Hepatocellular Cancer|Colorectal Cancer|Gastric Adenocarcinoma|Melanoma|Advanced Cancer
Interventions: DRUG: TTI-101|DRUG: TTI-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant HAIC and PD-1 Plus Adjuvant PD-1 for High-risk Recurrent HCC
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma|Beyond Milan Criteria
Interventions: DRUG: Neoadjuvant HAIC and PD-1 Plus Adjuvant PD-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of NVR 3-778 in Healthy Volunteers and Hepatitis B Patients
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: NVR 3-778|DRUG: Placebo for NVR 3-778|DRUG: Pegasys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: IDE397|DRUG: Docetaxel|DRUG: Paclitaxel|DRUG: Sacituzumab govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Teneligliptin (MP-513) in Combination With Insulin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Teneli (Teneligliptin)|DRUG: Placebo|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: DSTA4637S|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anti-diabetic Drugs on Bone Metabolism and Glycemic Variability
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Menopause|Osteoporosis|Osteopenia
Interventions: DRUG: Vildagliptin|DRUG: Gliclazide MR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dialectical Behavior Therapy Guided Self-Help for Binge Eating Disorder
Status: COMPLETED
Conditions: Binge Eating Disorder
Interventions: BEHAVIORAL: DBT Guided Self-Help|BEHAVIORAL: DBT Unguided Self-Help|BEHAVIORAL: Self-Esteem-Focused Unguided Self-Help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Pharmacokinetics and Antiviral Activity of Dolutegravir in the Central Nervous System in HIV-1 Infected ART-naive Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: Dolutegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects
Status: COMPLETED
Conditions: Pharmacokinetics|Drug Interactions|Hypercholesterolemia|Immunosuppression
Interventions: DRUG: 1 tablet Ezetrol(R) (ezetimibe), MSD Sharp & Dohme GmbH, Germany|DRUG: 1 capsule Prograf(R) (tacrolimus), Astellas Pharma GmbH, Germany|DRUG: 1 tablet Ezetrol(R) + 1 capsules Prograf(R)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess Drug Levels and Safety of Golcadomide (BMS-986369) in Healthy Participants and Participants With Different Degrees of Hepatic Impairment
Status: NOT_YET_RECRUITING
Conditions: Hepatic Impairment|Healthy Volunteers
Interventions: DRUG: BMS-986369
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of 48 Hours of Treatment With the Natural Peptide-Hormone GLP-1 in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: GLP-1|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: Fisetin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Data Acquisition to Model Glycemic Response
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Dexcom continuous glucose monitor|DEVICE: Fitbit activity tracker|BEHAVIORAL: Subjects record daily activity|BEHAVIORAL: Subjects record psychological state
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Iron Loading and Iron Chelation Therapy on Innate Immunity During Human Endotoxemia
Status: COMPLETED
Conditions: Systemic Inflammatory Process|Anemia
Interventions: DRUG: iron sucrose|DRUG: Deferasirox|DRUG: endotoxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)
Status: RECRUITING
Conditions: Long COVID|Long COVID-19|Hypersomnia
Interventions: DRUG: Modafinil|DRUG: Modafinil Placebo|DRUG: Solriamfetol|DRUG: Solriamfetol Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of BA3071 as Monotherapy and in Combination With a PD-1 Blocking Antibody (Currently Enrolling Patients With Nonsquamous or Recurrent NSCLC (Type IIB, IIIA, IV)
Status: RECRUITING
Conditions: NSCLC|Melanoma
Interventions: BIOLOGICAL: BA3071|BIOLOGICAL: Nivolumab|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Visit Clinical Validation of ScreenFire, a Low-cost HPV Test
Status: RECRUITING
Conditions: Human Papilloma Virus
Interventions: DIAGNOSTIC_TEST: ScreenFire HPV test|DIAGNOSTIC_TEST: careHPV test|PROCEDURE: Colposcopy and biopsy|PROCEDURE: Gas-based cryotherapy|PROCEDURE: Thermal ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Body Fat Reducing Effect and Safety of Enzymatically Modified Isoquercitrin in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight|Obese
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: EMIQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Insomnia|Cardiomyopathy
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)|BEHAVIORAL: Heart Failure Self-Management Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bevacizumab, Cisplatin, Etoposide, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: cisplatin|DRUG: etoposide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0623 in Patients With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: GDC-0623
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy Study of MBS303 in B-Cell NHL
Status: RECRUITING
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: MBS303
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT