pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy of Doses of LEO 43204 Once Daily for Two Consecutive Days on Full Balding Scalp in Subjects With Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LEO 43204|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Serotoninergic System in Multiple System Atrophy: a Positron Emission Tomography (PET) Study
Status: COMPLETED
Conditions: Multiple System Atrophy
Interventions: RADIATION: PET (Positron Emission Tomography) Study|OTHER: Brain MRI (magnetic resonance imaging)|DRUG: Fluoxétine / Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Repetitive Transorbital Alternating Current Stimulation in Acute Autoimmune Optic Neuritis
Status: TERMINATED
Conditions: Acute Autoimmune Inflammatory Optic Neuritis
Interventions: DEVICE: active-rtACS treatment|DEVICE: sham-rtACS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Migraine Headaches.
Status: UNKNOWN
Conditions: Chronic Migraine Without Aura, Intractable|Migraine With Typical Aura|Migraine Disorders
Interventions: COMBINATION_PRODUCT: Dexamethasone, Lidocaine, Thiamine cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spine SABR - Dose-escalated Stereotactic Ablative Body Radiotherapy (SABR) for Solid Tumour Spine Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor Spine Metastases
Interventions: RADIATION: Radiation: image guided dose escalated SABR using a simultaneous integrated boost (SIB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing hCG Triggering Versus GnRH Agonist Triggering in PCOS Patients
Status: COMPLETED
Conditions: Infertility|PCOS
Interventions: DRUG: GnRh agonist +1500E hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RVU120 in Patients With Intermediate or High-risk, Primary or Secondary Myelofibrosis
Status: NOT_YET_RECRUITING
Conditions: Myelofibrosis
Interventions: DRUG: RVU120|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: 7-hydroxystaurosporine|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Prospective Study of the Health Benefits of Ultra-Violet Filtering Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: narafilcon A contact lens|DEVICE: nelfilcon A soft contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CORE: Study to Evaluate the Conducted AF-Response-Algorithm in Patients Suffering From Heart Failure and Atrial Fibrillation
Status: TERMINATED
Conditions: Heart Failure|Sudden Cardiac Death|Atrial Fibrillation
Interventions: DEVICE: Conducted AF-Response Algorithm (CAFR) On|DEVICE: Conducted AF-Response Algorithm (CAFR) Off
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Allogeneic Mesenchymal Bone Marrow Cells in Subjects With Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: BIOLOGICAL: Allogeneic adult mesenchymal bone marrow stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IV Study to Evaluate the Effects of Statin Monotherapy or Statin / Ezetimibe Combination Therapy on Hepatic Steatosis in Patients With Hyperlipidemia and Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease|Dyslipidemias
Interventions: DRUG: Rosuvastatin|DRUG: Rosuvastatin/ezetimibe combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Injury Prevention & Rehabilitation in Military Personnel
Status: COMPLETED
Conditions: Muscle Injury
Interventions: PROCEDURE: Healthy Muscle Group|PROCEDURE: Stretch-Contract Pre-rehabilitation Group|PROCEDURE: Stretch-Contract Control Group|PROCEDURE: Muscle Atrophy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Homeopathic-Based Treatment Approaches to Reduce the Prevalence of Malaria in Depressed Communities
Status: COMPLETED
Conditions: Malaria
Interventions: OTHER: Malaria Tropica Nosode D200
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effect of Dexamethasone in Postoperative Symptoms After Mastectomy for Breast Cancer
Status: COMPLETED
Conditions: Postoperative Pain|Postoperative Nausea|Postoperative Vomiting
Interventions: DRUG: intravenous dexamethasone|DRUG: Homologated placebo.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia Delivery System
Status: RECRUITING
Conditions: Obesity, Morbid|Anesthesia|Propofol
Interventions: DRUG: Propofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068)
Status: COMPLETED
Conditions: Hepatitis A Virus
Interventions: BIOLOGICAL: Comparator: VAQTA™|BIOLOGICAL: Comparator: Infanrix™|BIOLOGICAL: Comparator: PedvaxHIB™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))
Status: NOT_YET_RECRUITING
Conditions: Erythema Migrans of Lyme Disease
Interventions: DRUG: Amoxicillin + Saccharomyces boulardii CNCM I-745|DRUG: Amoxicillin + Placebo|OTHER: Stool samples|OTHER: BSFS : Bristol Stool Form Scale|OTHER: GSRS : Gastrointestinal Symptom Rating Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound-Based Imaging Using the Aixplorer System in Diagnosing Prostate Cancer in Patients Undergoing Biopsy
Status: COMPLETED
Conditions: Prostate Carcinoma
Interventions: PROCEDURE: Shear Wave Elastography|PROCEDURE: Ultrasound Elasticity Imaging|PROCEDURE: Ultrasound-Guided Prostate Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Acute Disease|Thrombosis|Heart Diseases|Stroke
Interventions: OTHER: Doppler echocardiogram exam|OTHER: Carotid duplex ultrasound exam|OTHER: Cardiac MRI|OTHER: Brain MRI|PROCEDURE: Reveal LINQ insertable cardiac monitoring system|OTHER: Coagulation blood test|OTHER: Transcranial Doppler monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intraoperative Fluorescence Angiography in Debridement of Open Fractures
Status: NOT_YET_RECRUITING
Conditions: Intraoperative Fluorescence Angiography
Interventions: DEVICE: Intraoperative fluorescence angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH)
Status: ENROLLING_BY_INVITATION
Conditions: Familial Hypercholesterolemia
Interventions: BEHAVIORAL: FH diagnosis program|BEHAVIORAL: Implementation strategy package: Develop and implement tools for quality monitoring|BEHAVIORAL: Implementation strategy package: Develop educational materials|BEHAVIORAL: Implementation strategy package: Conduct educational outreach visits|BEHAVIORAL: Implementation strategy package: Intervene with clinicians and patients to enhance|BEHAVIORAL: Behavioral (e.g., Psychotherapy, Lifestyle Counseling) Implementation strategy package: Identify and prepare champions Clinical lipid champions|BEHAVIORAL: Implementation strategy package: Audit and provide feedback|BEHAVIORAL: Implementation strategy package: Stage implementation scale up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: NVP-1805 Compared to Coadministration of NVP-1805-R1 With NVP-1805-R2 in Healthy Adult Volunteers (BE)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: NVP-1805|DRUG: NVP-1805-R1 and NVP-1805-R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LUCAR-20S in Patients With R/R NHL
Status: TERMINATED
Conditions: Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma|Small Lymphocytic Lymphoma
Interventions: DRUG: LUCAR-20S CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMC114IFD3001 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir(Rtv) in HIV1 Infected Adults, Adolescents and Children Aged 3 Years or Above and Coming From Previous Company Sponsored Studies With DRV
Status: COMPLETED
Conditions: HIV-1 Infections
Interventions: DRUG: Darunavir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Periodontal Treatment for the Glycemic Conttrol of Type II Diabetes Mellitus
Status: RECRUITING
Conditions: Patient Compliance
Interventions: PROCEDURE: periodontal care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Optimising Azithromycin Prevention Treatment in COPD to Reduce Exacerbations
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Azithromycin Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Functionality, Safety and Efficacy Study in Patients Undergoing Elective Unilateral Knee Replacement
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Sufentanil NanoTab PCA System/15 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Transcranial Magnetic Stimulation (dTMS) to Induce Smoking Cessation
Status: UNKNOWN
Conditions: Smoking Cessation|Transcranial Magnetic Stimulation
Interventions: DEVICE: Deep Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kineflex|C Artificial Disc System to Treat Cervical Degenerative Disc Disease (DDD)
Status: TERMINATED
Conditions: Degenerative Disc Disease (DDD)
Interventions: DEVICE: Artificial disk|DEVICE: Artificial disc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults
Status: COMPLETED
Conditions: Cognitive Function|Motor Activity|Obesity
Interventions: BEHAVIORAL: Experimental: High Intensity Interval|BEHAVIORAL: Resistance training|BEHAVIORAL: Plus: High Intensity Interval + Resistance Training|OTHER: Non-exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Safety & Efficacy of the Combination of LJM716 & BYL719 in Patients With Previously Treated Esophageal Squamous Cell Carcinoma (ESCC)
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: LJM716|DRUG: BYL719|DRUG: Paclitaxel|DRUG: Docetaxel|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Investigate the Effect of Esketamine Hydrochloride on Pulmonary Complications
Status: RECRUITING
Conditions: Heart Diseases|Heart Valve Diseases
Interventions: DRUG: Esketamine hydrochloride injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Management of Diabetes in Everyday Life Program
Status: UNKNOWN
Conditions: Diabetes Mellitus|Chronic Disease
Interventions: BEHAVIORAL: Text Messaging (TM)|BEHAVIORAL: Health Coaching (HC)|BEHAVIORAL: Enhanced Usual Care (EC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting the Skeletal Muscle to Treat Metabolic Dysfunction-associated Steatotic Liver Disease
Status: NOT_YET_RECRUITING
Conditions: Metabolic Dysfunction-associated Steatotic Liver Disease
Interventions: OTHER: High-intensity interval training|OTHER: Moderate intensity exercise training|OTHER: Low intensity exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Cardiac Rehabilitation Program in Patients With Heart Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: BEHAVIORAL: Interdisciplinary educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of ZSP1273 in Participants With Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment|Pharmacokinetics
Interventions: DRUG: ZSP1273|DRUG: ZSP1273|DRUG: ZSP1273
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Childhood Germ Cell Tumor|Extragonadal Germ Cell Tumor|Liver Cancer|Neuroblastoma|Ovarian Cancer|Sarcoma|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: etoposide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Intravenous Anesthesia Versus Sevoflurane Anesthesia for Endovascular Thrombectomy in Acute Ischemic Stroke
Status: RECRUITING
Conditions: Ischemic Stroke, Acute|Thrombectomy|General Anesthesia|Total Intravenous Anesthesia|Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: BEHAVIORAL: Cognitive function and delirium evaluation|BEHAVIORAL: Neurological functional assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse Managed Sequential Strength Training and Bicycle Training in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Resistance training|BEHAVIORAL: Aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sequential Anlotinib Followed by EP Regimen Plus Concurrent Radiotherapy for Unresectable Stage III Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Unresectable Stage III Non-small Cell Lung Cancer
Interventions: DRUG: Anlotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Dose Study Of PF-04603629 In Type 2 Diabetic Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: PF-04603629
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence in Echocardiography
Status: WITHDRAWN
Conditions: Cardiovascular Diseases
Interventions: DEVICE: Bay Labs EchoGPS Echcoardiogram|DEVICE: Native Terason Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection
Status: TERMINATED
Conditions: Pulmonary Infection|Covid-19
Interventions: DRUG: T3 solution for injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PeRsonalIzed remOtely Guided Preventive exeRcIse Therapy for a healThY Heart
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: BEHAVIORAL: PRIORITY|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Efficacy and Safety of Tolnaftate Cream in the Treatment of Patients With Fungal Infections
Status: UNKNOWN
Conditions: Fungal Infections|Tinea Pedis|Tinea Cruris|Tinea Corporis
Interventions: DRUG: Clotrimazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of StellaLife Oral Care Recovery Kit on Palatal Wound Healing After Free Gingival Graft
Status: NOT_YET_RECRUITING
Conditions: Wound Heal
Interventions: PROCEDURE: Free Gingival Graft Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Kinematics of Knees of Patients With Tumor Around Knee After Microwave Ablation With Plate Internal Fixation
Status: UNKNOWN
Conditions: Knee Tumor|Microwave
Interventions: PROCEDURE: Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab
Status: RECRUITING
Conditions: Unresectable Metastatic Colorectal Cancer
Interventions: DRUG: ABBV-400|DRUG: Bevacizumab|DRUG: Folinic Acid|DRUG: Fluorouracil|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation in Spinal Muscular Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Muscular Atrophy Type 3|Spinal Muscular Atrophy Type 4
Interventions: DEVICE: Spinal Cord Stimulator (octopolar Medtronic Vectris Leads)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reolysin Combined With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in Metastatic Castration Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel, Reolysin and Prednisone|DRUG: Docetaxel and Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Everolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Mechanism of Yisui Granule in Treatment of Low and Medium Risk Myelodysplastic Syndrome Through Demethylation
Status: NOT_YET_RECRUITING
Conditions: MDS
Interventions: DRUG: Yisui granule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Disitamab Vedotin Plus Pyrotinib or Naratinib in HER2-positive Breast Cancer Patients With Brain Metastasis
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Disitamab Vedotin plus pyrotinib or naratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Exploratory Efficacy Study of SF0166 for the Treatment of Diabetic Macular Edema (DME)
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: SF0166 Topical Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
Status: COMPLETED
Conditions: Papillomavirus Infections|Dysplasia|Cervix Cancer
Interventions: OTHER: Vaginal samples (biopsies + vaginal smear)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation
Status: UNKNOWN
Conditions: Invasive Pulmonary Aspergillosis
Interventions: DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Investigating the Use of Fluorescent Lectins to Identify Dysplasia and Cancer During Endoscopy and Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Polyp
Interventions: DRUG: Fluorescent Lectin Application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Avastin (Bevacizumab) in Combination With Gemcitabine With or Without Cisplatin in First-Line Treatment of Elderly Patients With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: cisplatin|DRUG: gemcitabine|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Lonafarnib / Ritonavir With and Without Pegylated Interferon -Alfa-2a
Status: COMPLETED
Conditions: Hepatitis Delta Virus
Interventions: DRUG: Lonafarnib|DRUG: Ritonavir|DRUG: PEG IFN-alfa-2a|DRUG: Placebo Lonafarnib|DRUG: Placebo Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib (Gleevec(Registered Trademark)) to Treat Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia|Chronic Myelogenous Leukemia
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Promyelocytic Leukemia (M3)|Blastic Phase Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Relapsing Chronic Myelogenous Leukemia
Interventions: DRUG: BMS-214662|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Hydrating Cream to Improve Repeated Hand Skin Injury Among Tug-of-war Players
Status: NOT_YET_RECRUITING
Conditions: Athletic Injuries|Eczematous Skin Diseases|Skin Avulsion
Interventions: DRUG: Hydrating Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
Status: RECRUITING
Conditions: E Cigarette Use
Interventions: DIAGNOSTIC_TEST: Hyperpolarized Xenon-129 MRI of the lungs|DIAGNOSTIC_TEST: Computed Tomography (CT)|DIAGNOSTIC_TEST: Pulmonary Function Tests (PFT)|DIAGNOSTIC_TEST: Cardiopulmonary exercise testing (CPET)|DIAGNOSTIC_TEST: Sputum analysis|DIAGNOSTIC_TEST: Blood analysis|OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Invention of Portable Laser Acupuncture and Joint Mobilization Device on Frozen Shoulder and Therapeutic Effects
Status: UNKNOWN
Conditions: Frozen Shoulder
Interventions: OTHER: Rehabilitation exercise|DEVICE: joint mobilization device treatment|DEVICE: laser acupuncture device treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Non-Vascular Renal Denervation Using the Verve Medical Phoenix ™ System
Status: UNKNOWN
Conditions: Hypertension|Uncontrolled Hypertension
Interventions: DEVICE: Renal Pelvic Denervation (bilateral)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Esketamine on Postpartum Depression
Status: UNKNOWN
Conditions: Postpartum Depression
Interventions: DRUG: Esketamine is not added|DRUG: Esketamine 0.2mg/kg|DRUG: Esketamine 0.4mg/kg|DRUG: Esketamine 0.6mg/kg|DRUG: Esketamine 0.8mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Effectiveness of Apidra® in Combination With Basal Insulin in Patients With Type 1 & 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Insulin Glulisine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine Skin Irritation Potential of an Antifungal Cream Containing Trolamine After Repeated Skin Application (Cumulative Irritation Patch Test)
Status: COMPLETED
Conditions: Hypersensitivity
Interventions: DRUG: Butenafine HCl 1% (BAY1896425)|DRUG: Positive Control-Sodium lauryl sulfate (SLS)|OTHER: Negative Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KUL0401: An Open-label Pilot Study of Oxatomide in Steroid-Naive Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: Oxatomide (tinset)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serplulimab Combined With Chemotherapy in Patients With Resectable Non-small-cell Lung Cancer
Status: RECRUITING
Conditions: NSCLC|Neoadjuvant Therapy
Interventions: DRUG: Serplulimab and neoadjuvant therapy|PROCEDURE: surgical resection of lung cancer|OTHER: Tumour will be Collected from participant. Fate of sample is Destruction after use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software
Status: ENROLLING_BY_INVITATION
Conditions: Long QT Syndrome|Sinus Bradycardia|Sinus Tachycardia|Premature Atrial Complexes|Premature Ventricular Complexes|Atrial Flutter|Right Bundle-Branch Block|Left Bundle-Branch Block|Left Ventricular Hypertrophy|Myocardial Infarction
Interventions: DRUG: Chang Gung ECG Abnormality Detection Software
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PD-1 Antibody in Addition to BACE in Patients With NSCLC: A Randomised Controlled Trial
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: PD-1 Antibody|DEVICE: BACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: National Multicenter Cohort Study of Robot-Assisted Gastrectomy Versus Laparoscopy in Gastric Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Gastric Cancer
Interventions: PROCEDURE: Robot-Assisted Gastrectomy|PROCEDURE: Laparoscopic Gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultra-Congruent(UC) Versus Posterior-stabilized(PS) Insert in Bilateral Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Ultra-Congruent(UC) Insert
Interventions: PROCEDURE: total knee arthroplasty with ultra-congruent (UC) insert|PROCEDURE: total knee arthroplasty with posterior-stabilized (PS) insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ExeNTrO: Exercise During Neoadjuvant Chemoradiation Treatment to Improve Rectal and Esophageal Cancer Outcome - Pilot Trial
Status: RECRUITING
Conditions: Oncology
Interventions: BEHAVIORAL: combined aerobic exercise + resistance exercise intervention (AE + RE)|BEHAVIORAL: Aerobic exercise prior to daily radiotherapy sessions (ExPR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy
Status: COMPLETED
Conditions: Carotid Artery Disease|Stroke|Amaurosis Fugax|Transient Ischemic Attack (TIA)
Interventions: DEVICE: RX Acculink Carotid Stent System (RX Acculink)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intra-Canal Cryotherapy on Postoperative Pain After Endodontic Procedures
Status: ACTIVE_NOT_RECRUITING
Conditions: Endodontically Treated Teeth|Post Operative Pain
Interventions: DRUG: cryotherapy with sterile saline at 2.5ºC|DRUG: control with sterile saline at room temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Quantitative Assessment and Characterization of Microvascular Function Using Diffuse Optical Tomography
Status: COMPLETED
Conditions: Atherosclerosis|Diabetes|Coronary Artery Disease
Interventions: DEVICE: diffuse optical tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics of GLPG3067 in Male Subjects With Cystic Fibrosis.
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: GLPG3067 single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess the Effect of Testosterone in Patients With Poor Ovarian Response (TESTOPRIM)
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: GROUP 1: Long testosterone|DRUG: GROUP 2: Short testosterone|DRUG: GROUP 3: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Potential Effect Of Lansoprazole On The Pharmacokinetics Of Bosutinib In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bosutinib|DRUG: Bosutinib|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Remediation Therapy for Adolescents With Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: CRT + Teach the Parent|BEHAVIORAL: CRT + Contact Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BB-101 for the Treatment of Diabetic Lower Leg and Foot Ulcers
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: BIOLOGICAL: BB-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of a Nasal Mask for the Treatment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Obstructive Sleep Apnea
Interventions: DEVICE: F&P nasal mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Invest-CTO PCI Trial
Status: RECRUITING
Conditions: Chronic Total Occlusion of Coronary Artery|Angina Pectoris|Quality of Life|PROM
Interventions: PROCEDURE: Chronic total occlusion(CTO) percutaneous coronary intervention (PCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haemodynamic Effects of GLP-1 and Glucagon in Healthy Male Volunteers
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Saline 0.9%|DRUG: Glucagon (25ng/kg/min)|DRUG: Glucagon (50ng/kg/min)|DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Oral Nutritional Supplements on Patients Undergoing Haematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Haematological Malignancy
Interventions: DIETARY_SUPPLEMENT: Traditional Control|DIETARY_SUPPLEMENT: Oral Nutritional Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of LP-168 in Healthy Volunteers
Status: COMPLETED
Conditions: Multiple Sclerosis|NMO Spectrum Disorder
Interventions: DRUG: LP-168 tablet|DRUG: LP-168 Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With Neratinib
Status: COMPLETED
Conditions: HER2 Amplified Breast Cancer
Interventions: DRUG: Neratinib|DRUG: Capecitabine|DRUG: Loperamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Screening for Latent Tuberculosis Infection (LTBI) in US Army Recruits
Status: COMPLETED
Conditions: Latent Tuberculosis Infection
Interventions: DRUG: BST|DRUG: TST|OTHER: QFT|OTHER: T-spot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Benefit of Machine Learning to Diagnose Deep Vein Thrombosis Compared to Gold Standard Ultrasound
Status: WITHDRAWN
Conditions: Deep Venous Thrombosis of Leg|Deep Vein Thrombosis
Interventions: DEVICE: 3-compression Ultrasound scan with AutoDVT software integrated Ultrasound probe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Empagliflozin and Atrial Fibrillation Treatment
Status: UNKNOWN
Conditions: Atrial Fibrillation|Heart Failure|Obesity|Diabetes Mellitus
Interventions: DRUG: Empagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine After Cesarean Delivery
Status: WITHDRAWN
Conditions: Pain, Postoperative|Opioid Use
Interventions: DRUG: Exparel|OTHER: Saline infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating OsseoSpeed™ Narrow Implant in the Upper and Lower Anterior Jaw
Status: COMPLETED
Conditions: Jaw, Edentulous, Partially
Interventions: DEVICE: OsseoSpeed™ TX 3.0S
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of HLX26 (Anti-LAG-3 Monoclonal Antibody Injection) Combined With Serplulimab and Chemotherapy in Previously Untreated Advanced NSCLC Patients
Status: RECRUITING
Conditions: NSCLC Stage IV
Interventions: DRUG: HLX26|DRUG: Serplulimab|DRUG: Chemotherapy drug|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia in Bilateral Knee Arthroplasties
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Arthroplasty, Total|Peripheral Nerve Block|Pain, Postoperative
Interventions: PROCEDURE: Bilateral Suprainguinal fascia iliaca compartment block|PROCEDURE: Local infiltration analgesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Status: COMPLETED
Conditions: Pulmonary Arteriovenous Malformations|Hereditary Hemorrhagic Telangiectasia
Interventions: OTHER: Cardiopulmonary exercise test|PROCEDURE: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 3VM1001 Cream for the Treatment of Pain Associated With Post Herpetic Neuralgia (PHN)
Status: COMPLETED
Conditions: Treatment of PHN
Interventions: DRUG: 3VM1001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open-label, Single-center, Study of the ACUSURGICAL Luca System for Treatment of Vitreoretinal Diseases
Status: RECRUITING
Conditions: Vitreoretinal Disease
Interventions: DEVICE: vitreoretinal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of a Study Medication on Exercise Function in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Acipimox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Effects GRC 17536 in Patients With Painful Diabetic Peripheral Neuropathy (Painful Extremities Due to Peripheral Nerve Damage in Diabetic Patients).
Status: COMPLETED
Conditions: Painful Diabetic Peripheral Neuropathy
Interventions: DRUG: GRC 17356|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer Stage II
Interventions: DRUG: Bevacizumab and FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - XT Intermediate and High Risk
Status: COMPLETED
Conditions: Symptomatic Severe Aortic Stenosis
Interventions: DEVICE: TAVR Implantation with SAPIEN XT|DEVICE: SAVR Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Elacestrant in Combination With Onapristone in Patients With Advanced or Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Elacestrant|DRUG: Onapristone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients
Status: UNKNOWN
Conditions: Mechanical Ventilation|Complication|Delirium
Interventions: DRUG: midazolam|DRUG: Fentanyl|DRUG: propofol|DRUG: Dexmedetomidine|PROCEDURE: Procedure:sedation assessment|PROCEDURE: Procedure:Weaning|DRUG: midazolam(used for passing the SBT safety screen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study for Patients With Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell|Neoplasm Metastasis
Interventions: DRUG: FK228 (romidepsin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fructose Breath-testing in Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders|Irritable Bowel Syndrome
Interventions: PROCEDURE: Open breath test with fructose|PROCEDURE: Breath test with sweet placebo (Assugrin)|PROCEDURE: Breath test with neutral placebo (still water)|PROCEDURE: Blinded breath test with fructose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Correlation Between RECIST, Morphologic Response by CT- Histopathologic Response in Hepatic Metastasis Secondary to Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Hepatic Metastasis
Interventions: OTHER: Evaluate the correlation of overall different objective response.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of TD-4208 on FEV1 in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease, COPD
Interventions: DRUG: Placebo|DRUG: TD-4208 700 μg|DRUG: TD-4208 350 μg|DRUG: Ipratropium 500 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motivations, Attitudes, and Perceptions Study
Status: RECRUITING
Conditions: Alcohol Drinking|Sexual Violence|Social Norms
Interventions: BEHAVIORAL: Motivate-the-Bystander|BEHAVIORAL: Motivate-the-Bystander+Alcohol|BEHAVIORAL: Attention-only Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Follicle Size and Oocyte Development
Status: COMPLETED
Conditions: IVF Treatment
Interventions: DIAGNOSTIC_TEST: Follicle measurment|DRUG: Ovitrelle ( Hcg 250 mcg)|DRUG: Decapeptyl ( GnRH Agonist 0.1 mg*2 )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders
Status: COMPLETED
Conditions: Pemphigus|Auto-immune Thrombocytopenic Purpura|Hemolytic Auto-immune Anaemia|Cold Agglutinin Disease|Cryoglobulinemia
Interventions: DRUG: Rituximab (MABTHERA® or RITUXAN®).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tolerability of a Foaming Facial Cleanser and Moisturizer SPF 30 in a Pediatric Population (7-11) With Acne Prone Skin.
Status: COMPLETED
Conditions: Acne Prone Skin
Interventions: DRUG: Facial Cleanser and Moisturizer SPF 30
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Placebo|DRUG: Omecamtiv mecarbil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT