pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Pilates Exercises On Fatigue In Post Menopausal Women
Status: UNKNOWN
Conditions: Fatigue
Interventions: OTHER: Pilates exercises|DIETARY_SUPPLEMENT: medical standard care for fatigue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 TAK-041 First-in-Human Safety, Tolerability, and Pharmacokinetics Study
Status: COMPLETED
Conditions: Healthy Volunteers|Schizophrenia
Interventions: DRUG: TAK-041|DRUG: TAK-041 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Long-Term Efficacy of Ramelteon on Endocrine Function in Adult Subjects With Chronic Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Ramelteon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Amputation Surgical Site Infection Trial (ASSIT)
Status: COMPLETED
Conditions: Wound Infection|Amputation Wound
Interventions: DRUG: Co-amoxiclav|DRUG: Iodine|DRUG: Metronidazole|DRUG: Chlorhexidine|DRUG: Teicoplanin|DRUG: Clindamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Bintrafusp Alfa (M7824) in Checkpoint Inhibitor Naive and Refractory Subjects With Urothelial Carcinoma
Status: TERMINATED
Conditions: Urothelial Cancer
Interventions: DRUG: Bintrafusp alfa (M7824)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Depth Control Using CLADS vs. TCI in Patients With LVSDF
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: Target Controlled Infusion|DEVICE: Closed Loop Anesthesia Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate the Efficacy of AlphaWave® L-Theanine on Stress
Status: COMPLETED
Conditions: Stress
Interventions: DIETARY_SUPPLEMENT: AlphaWave® LTheanine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Assessment of Pain and Treatment Success After VPT Versus RCT in Mature Permanent Mandibular Molars With SIP: A RCT
Status: NOT_YET_RECRUITING
Conditions: Symptomatic Irreversible Pulpitis
Interventions: PROCEDURE: Root canal treatment|PROCEDURE: Vital pulp therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Using Fluorine-18-Labeled Fluoro-Misonidazole Positron Emission Tomography To Detect Hypoxia in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: RADIATION: fluorine-18-labeled fluoro-misonidazole (18F-FMISO)|DEVICE: 18F-FMISO PET scan|DEVICE: MRI|DEVICE: FDG PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Effects of Cortexolone 17α-propionate (and Its Metabolites) on Healthy Volunteers' Heart
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Cortexolone 17α-propionate solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury
Status: RECRUITING
Conditions: Sleep Apnea|Spinal Cord Injury
Interventions: PROCEDURE: Acute episodic hypoxia|PROCEDURE: Supplemental oxygen|DRUG: Trazodone|DRUG: Placebo|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative Symptoms
Status: RECRUITING
Conditions: Chronic Sinusitis
Interventions: PROCEDURE: steroid-eluting sinus stent implant|DRUG: Systemic glucocorticoids|DRUG: saline irrigations|DRUG: Placebo|PROCEDURE: sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ANNAPURNA: A Study of The Combination of RO5466731, RO5190591, Ritonavir and Copegus (Ribavirin) With or Without RO5024048 in Patients With Chronic Hepatitis C Who Are Either Treatment-Naïve or Have Previously Experienced a Null Response to Interferon-Based Treatment
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: RO5024048|DRUG: RO5190591|DRUG: RO5466731|DRUG: ribavirin [Copegus]|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perineural Platelet-rich Plasma for Diabetic Neuropathy Pain
Status: COMPLETED
Conditions: Diabetic Neuropathies|Chronic Pain
Interventions: OTHER: perineural injection of platelet-rich plasma|DRUG: medical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupuncture Augmented With Pelvic Floor Exercises on Overactive Bladder
Status: RECRUITING
Conditions: Overactive Bladder Syndrome
Interventions: DEVICE: Acupuncture|OTHER: pelvic floor exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Mixed Phenotype Acute Leukemia
Interventions: DRUG: Blinatumomab|DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Sudy of Atazanavir Boosted With Ritonavir in the Treatment of HIV Infection in Pediatric Patients
Status: COMPLETED
Conditions: HIV, Pediatric
Interventions: DRUG: Atazanavir|DRUG: Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Cytokine-induced Killer Immunotherapy for Relapse After Allogeneic Marrow Transplant for Haematological Malignancies
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Chronic Myeloid Leukemia|Non Hodgkin's Lymphoma|Hodgkin's Disease|Myelodysplastic Syndrome|Multiple Myeloma
Interventions: BIOLOGICAL: infusion of allogeneic CIK cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance of Physical Activity After Cardiac Rehabilitation
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Heart Diseases|Myocardial Ischemia|Heart Failure|Arrythmia|Heart Arrest
Interventions: BEHAVIORAL: Maintenance intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Preoperative Active Warming and Passive Warming Methods on Perioperative Hypothermia
Status: COMPLETED
Conditions: Hypothermia|Perioperative Care|Vital Signs|Rewarming
Interventions: PROCEDURE: Pre Heating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study on the Effectiveness of WeChat-based Online Education to Reduce Perioperative Anxiety in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: BEHAVIORAL: follow the WeChat public platform to watch the education videos|BEHAVIORAL: regular preoperative visits and education by ward nurses.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sequential Therapy of Atorvastatin Improve Outcomes of ST-elevated Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Sequential therapy of atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Chronic Kidney Disease on Clopidogrel Effects in Diabetes Mellitus
Status: COMPLETED
Conditions: Chronic Kidney Disease (CKD)|Type 2 Diabetes Mellitus (T2DM)|Coronary Artery Disease (CAD)
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel active metabolite
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colistin Versus Colistin Plus Fosfomycin for Infections Caused by MDR Acinetobacter Baumannii
Status: UNKNOWN
Conditions: Drug Safety
Interventions: DRUG: colistin|DRUG: colistin plus fosfomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone as a Treatment for Lipid and Glucose Abnormalities In Patients With Schizophrenia
Status: COMPLETED
Conditions: Diabetes|Schizophrenia|Insulin Resistance|Cognitive Impairment
Interventions: DRUG: Pioglitazone|BEHAVIORAL: Life style diet group|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cladribine and Rituximab in Treating Patients With Hairy Cell Leukemia
Status: RECRUITING
Conditions: Hairy Cell Leukemia|Recurrent Hairy Cell Leukemia
Interventions: DRUG: Cladribine|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoring Sinus Rhythm With Cardiac Resynchronization in Patients With Atrial Fibrillation (ReSync AF)
Status: COMPLETED
Conditions: Heart Failure, Atrial Arrhythmia
Interventions: DEVICE: Cardiac Resynchronization Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Consuming a guaraná and Vitamin/Mineral Complex Pre-exercise on Affect, Exertion, Metabolism and Cognition
Status: COMPLETED
Conditions: Affect and Exertion During and Post-exercise
Interventions: DIETARY_SUPPLEMENT: Berocca Boost|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Proportional Assisted Ventilation on Dyspnea and Asynchrony in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Dyspnea
Interventions: DEVICE: PAV, Puritan Bennett 980 ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Effects of Different Enterostomy Approaches
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Neoplasms Malignant|Intestinal Neoplasms, Malignant
Interventions: PROCEDURE: Ileostomy|PROCEDURE: Transverse colostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navigating Pregnancy and Parenthood With Lyme Disease
Status: RECRUITING
Conditions: Lyme Disease|Post Treatment Lyme Disease|Chronic Lyme Disease|Tick-Borne Infections|Tick-Borne Diseases|Pregnancy Complications|Parenting
Interventions: OTHER: Quantitative surveys and qualitative interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transoral Daytime Neuromuscular Electrical Stimulation in Patients With Simple Snoring
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Sleep Apnea|Sleep|Snoring
Interventions: DEVICE: Transoral Neurostimulation Device (Snoozeal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab
Status: COMPLETED
Conditions: Advanced Malignant Neoplasm|Dermatologic Complication
Interventions: DRUG: Doxycycline|PROCEDURE: Management of Therapy Complications|OTHER: Placebo|OTHER: Questionnaire Administration|DRUG: Spironolactone|DRUG: Sunscreen|DRUG: Therapeutic Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 12-week Open-label Evaluation of Efficacy and Safety of Indacaterol
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Indacaterol|DRUG: Long-acting beta2-agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Study for Efficacy of Uncovered Double Bare Metallic Stent Compared to Uncovered Single Bare Metallic Stent in Malignant Biliary Obstruction
Status: COMPLETED
Conditions: Malignant Biliary Obstruction
Interventions: PROCEDURE: metallic biliary stent insertion (double bare - S&G Biotech.)|PROCEDURE: metallic biliary stent insertion (single bare - S&G Biotech.)|PROCEDURE: metallic biliary stent insertion (single bare - Taewoong Medical.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Liver Fat Quantification (LFQ) Phase 2 Pilot Study
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Non-Alcoholic Steatohepatitis
Interventions: DEVICE: Investigational Liver Fat Quantification Software
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Oxidative Pathways in MS Fatigue
Status: COMPLETED
Conditions: Progressive Multiple Sclerosis|Fatigue
Interventions: DRUG: N-acetyl cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Noradrenergic Manipulation and Virtual Reality Exposure Therapy in Phobic Participants
Status: COMPLETED
Conditions: Phobic Disorders
Interventions: BEHAVIORAL: Virtual Reality Exposure Therapy (VRET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety of CHF 1535 (BDP +FF) Inhalation Powder, Administered Via the NEXT Inhaler, Versus CHF 1535 (BDP +FF), Administered Via a pMDI, in Moderate to Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: BDP/Formoterol Next DPI|DRUG: Foster|DRUG: BDP/Formoterol Next DPI|DRUG: Foster
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Feasibility of Wireless Electrocardiography
Status: COMPLETED
Conditions: Atrial Fibrillation|Premature Atrial and Ventricular Beats|Conduction Defects|Normal Sinus Rhythm
Interventions: DEVICE: Observational ambulatory ECG monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single Center Study to Evaluate the Efficacy and Safety of ETC 1002 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Hyperlipidemia|Type 2 Diabetes
Interventions: DRUG: ETC-1002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide vs CPAP on Cardiometabolic Outcomes in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Liraglutide (Saxenda) 6Mg/Ml Inj Pen 3Ml|DEVICE: Continuous positive airway pressure treatment|COMBINATION_PRODUCT: Liraglutide and CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Efficacy of Regorafenib in Metastatic Colorectal Cancer Patients and to Discover Biomarkers
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM)
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Momelotinib|DRUG: Placebo to match danazol|DRUG: Danazol|DRUG: Placebo to match momelotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa for Ovarian Stimulation in Donors
Status: COMPLETED
Conditions: Controlled Ovaria Stimulation
Interventions: DRUG: Desogestrel (DSG) and Corifolitropin (FSH-CTP) Alfa
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antineoplaston Therapy in Treating Patients With Recurrent or Stage IV Lung Cancer
Status: TERMINATED
Conditions: Bronchial Alveolar; Tumor
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Formalin-free Fixatives for In-Vivo Fixation of Skin Lesions.
Status: UNKNOWN
Conditions: Skin Abnormality
Interventions: DEVICE: Formulations for in-vivo fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Anakinra vs. Steroids for the Treatment of Gout Attacks in Patients With Renal Disease (ASGARD): A Feasibility Study
Status: COMPLETED
Conditions: Gout|Chronic Kidney Diseases
Interventions: DRUG: Anakinra 100mg and Placebo Depo-Medrone|DRUG: Depo-Medrone 120mg and Placebo (Anakinra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Subcutaneous Administration of Anakinra in Patients With CF
Status: RECRUITING
Conditions: Cystic Fibrosis, 10011762
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of the Drug RG1068 in Patients With Obsessive Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder (OCD)
Interventions: DRUG: RG1068 (Synthetic Human Secretin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Screening for Ovarian Cancer in Older Patients (PLCO Screening Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Carcinoma|Ovarian Germ Cell Tumor
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Screening Questionnaire Administration|PROCEDURE: Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Homoharringtonine Plus Low-Dose Cytarabine in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia in Chronic Phase
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia
Interventions: DRUG: omacetaxine mepesuccinate|DRUG: cytarabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of MGCD0103 Given Twice Weekly in Patients With Leukemia or Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: MGCD0103
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Coronary Syndrome and Acupressure
Status: NOT_YET_RECRUITING
Conditions: Acute Coronary Syndrome|Nursing
Interventions: OTHER: acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dihydromyricetin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Treatment Resistant Dermatitis TaroIIR
Status: COMPLETED
Conditions: Atopic Dermatitis|Psoriasis
Interventions: BEHAVIORAL: Phone calls|DRUG: Desoximetasone 0.25% spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic-pharmacodynamic Interaction Between BIA 3-202 and Levodopa/Benserazide
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: BIA 3-202|DRUG: Placebo|DRUG: levodopa 100 mg / benserazide 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Interventions: DRUG: Acalabrutinib|DRUG: Venetoclax|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess LY4100511 (DC-853) in Healthy Adult Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: LY4100511 (DC-853)|DRUG: Itraconazole|DRUG: Fluconazole|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality
Status: RECRUITING
Conditions: Helicobacter Pylori Infections|Atrophic Gastritis|Gastric Cancer
Interventions: DRUG: Triple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Minimally Invasive Locking Plate Fixation vs Reamed Intramedullary Nail Fixation on Patients With Open Tibia Fracture
Status: NOT_YET_RECRUITING
Conditions: Open tíbia Fracture
Interventions: PROCEDURE: Minimally Invasive Locking Plate Fixation|PROCEDURE: Intramedullary Nail Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engaging Patients in Adherence Interventions Using Behavioral Science
Status: NOT_YET_RECRUITING
Conditions: Uncontrolled Hypertension
Interventions: BEHAVIORAL: Primer postcard|BEHAVIORAL: Control recruitment letter|BEHAVIORAL: Behavioral theory-informed recruitment letter|BEHAVIORAL: 2 phone calls|BEHAVIORAL: 4 phone calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Saliva Testosterone Increases in Irritable Bowel Syndrome (IBS) Patients Beginning Choir Singing
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Choir singing|BEHAVIORAL: Information Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Functional Effects of Nusinersen in 5q-spinal Muscular Amyotrophy Adults (SMA Type 2 or 3 Forms)
Status: RECRUITING
Conditions: Spinal Muscular Atrophy
Interventions: OTHER: Monthly assessments of functional motor abilities by a trained therapist|DRUG: Nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Time Limited Trials to Reduce Non-Beneficial Intensive Care Unit Treatments
Status: COMPLETED
Conditions: Critical Illness|Communication
Interventions: BEHAVIORAL: Family meetings using time limited trials as default ICU communication and care planning approach|BEHAVIORAL: Usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Testing a Reduced Conditioning Regimen FB2A2 Preceded by a Fractionated Radio-immunotherapy (RIT) With 90Y-Epratuzumab Before Allogeneic Stem Cell Transplantation for Patients With Lymphocyte B CD22 Positive Acute Lymphoblastic Leukemia
Status: WITHDRAWN
Conditions: Lymphocyte B CD22 Positive Acute Lymphoblastic Leukemia
Interventions: DRUG: 90Y-DOTA-Epratuzumab IgG/Epratuzumab IgG|DRUG: Busulfan|BIOLOGICAL: allogeneic stem cell transplantation.|DRUG: Fludarabine|BIOLOGICAL: Thymoglobulines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso
Status: COMPLETED
Conditions: Malaria
Interventions: OTHER: Standard long-lasting insecticidal net|OTHER: Chlorfenapyr insecticide treated net|OTHER: Piperonyl butoxide long-lasting insecticidal net
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oesophageal Probe Evaluation in RF Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Placement of oesophageal probe for temperature measurement|DEVICE: Power limitation of RF generator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination Therapy vs. Oseltamivir Alone for Hospitalised Paediatric Influenza Patients
Status: COMPLETED
Conditions: Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination Therapy vs. Oseltamivir Alone for Hospitalised Paediatric Influenza Patients
Interventions: DRUG: clarithromycin-naproxen-oseltamivir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Preliminary Efficacy of Combination Therapy for the Treatment of Acne Vulgaris
Status: TERMINATED
Conditions: Acne Vulgaris|Acne
Interventions: DEVICE: Blue light phototherapy|DEVICE: Microcurrent therapy|DEVICE: Combination of BLP and Microcurrent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Papilloma Virus Vaccine Consistency and Non-inferiority Trial in Young Adult Women With GSK Bio HPV-16/18
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: HPV-16/18 L1/AS04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Perioperative Chemoradiotherapy for Potentially Resectable Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: PROCEDURE: Chemotherapy|PROCEDURE: surgery|PROCEDURE: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Combined Immunodeficiency
Interventions: DRUG: Anti-thymocyte globulin (rabbit)|DRUG: Busulfan|DRUG: Fludarabine|DRUG: Thiotepa|DEVICE: CliniMACS|OTHER: Donor Lymphocyte Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-Arm Study Comparing the Analgesic Efficacy and Safety of Tramadol HCl Once-a-Day Versus Placebo for the Treatment of Pain Due to Osteoarthritis
Status: COMPLETED
Conditions: Pain|Osteoarthritis
Interventions: DRUG: Tramadol Once a day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative ICG Fluorescence Imaging for Peritoneal Carcinomatosis Detection
Status: UNKNOWN
Conditions: Peritoneal Carcinomatosis|Gastric Cancer
Interventions: DIAGNOSTIC_TEST: Fluorescence guided peritoneal exploration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combined Use of a Novel Cardioplegic Formula With MPS® Versus Cardioplexol ® in Urgent Isolated CABG Using MiECC in Patients With Recent Acute Myocardial Infarction
Status: COMPLETED
Conditions: Heart Attack|Cardioplegia Solution Adverse Reaction|Coronary Artery Bypass Grafting (CABG)
Interventions: OTHER: Myocardial protection system (MPS)|OTHER: Cardioplexol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Cost-effectiveness Study of Single Port Laparoscopic Cholecystectomies
Status: COMPLETED
Conditions: Cholecystolithiasis
Interventions: PROCEDURE: Single Trocar CCK|PROCEDURE: Standard CCK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Two Types of Non-invasive Erector Spinae Muscle Taut Band Therapy in University Students With Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Trigger Point Pain, Myofascial
Interventions: OTHER: Jones Group (Strain Counterstrain)|OTHER: Myofascial Induction Group|OTHER: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728mR in HIV-Infected Patients
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)
Interventions: DRUG: ZFN Modified CD4+ T Cells|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acamprosate Initiated During Alcohol Detoxification
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Acamprosate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ph I Study in Adult Patients With Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: NMS-03597812|DRUG: NMS-03597812 + dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Transdermal Metronidazole
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Metronidazole 0.75% Topical Gel|DRUG: Metronidazole 0.75% Topical Cream|DIAGNOSTIC_TEST: Transdermal water loss measurement|DIAGNOSTIC_TEST: Electrical Resistance|DIAGNOSTIC_TEST: Skin color measurement|OTHER: Micropatch application
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interprofessional Training to Improve Diabetes Care: The ReSPECT Trial
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Role modeling in Shared medical appointments to Promote Establishing Collaborative Teams (ReSPECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-interventional Study to Investigate the Short and Long Term Real-life Safety, Effectiveness, and Adherence of Velphoro® in Patients With Hyperphosphataemia Undergoing Haemodialysis (HD) or Peritoneal Dialysis (PD)
Status: COMPLETED
Conditions: Hyperphosphatemia
Interventions: DRUG: sucroferric oxyhydroxide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Observational Post-Authorization Safety Specialist Cohort Event Monitoring Study (SCEM) to Monitor the Safety and Utilization of Rivaroxaban (Xarelto®).
Status: COMPLETED
Conditions: Atrial Fibrillation|Deep Vein Thrombosis|Pulmonary Embolism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketamine Co-induction for Patients With Major Depressive Disorder
Status: UNKNOWN
Conditions: Ketamine|Depression|Anesthesia
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Propofol|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure
Status: COMPLETED
Conditions: Liver Failure
Interventions: DRUG: entecavir|DRUG: Traditional comprehensive medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panitumumab After Resection of Liver Metastases From Colorectal Cancer in KRAS Wild-type Patients
Status: UNKNOWN
Conditions: Colorectal Cancer|KRAS Wildtype|After Resection of Liver Metastases
Interventions: DRUG: Folic Acid|DRUG: 5-FU|DRUG: 5-FU|DRUG: Oxaliplatin|DRUG: Panitumumab|DRUG: Panitumumab|DRUG: Folic Acid|DRUG: 5-FU|DRUG: 5-FU|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketoconazole, Hydrocortisone, and GM-CSF in Treating Patients With Progressive Prostate Cancer After Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: sargramostim|DRUG: ketoconazole|DRUG: therapeutic hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UMCC 003 Cancer-Related Protein Biomarkers in Blood and Tumor Tissue of Patients With Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Esophageal Cancer|Liver Cancer|Lung Cancer|Ovarian Cancer|Pancreatic Cancer
Interventions: GENETIC: fluorescence in situ hybridization|GENETIC: polymerase chain reaction|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: mass spectrometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Edinburgh and Lothian Virus Intervention Study in Kids
Status: COMPLETED
Conditions: Upper Respiratory Tract Infections|Virus|Virus Shedding|Pediatric ALL
Interventions: OTHER: Na Cl solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Appeal of Nicotine Pouches Versus Cigarettes in the Ohio Appalachia Population
Status: COMPLETED
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: BEHAVIORAL: Cigarette Smoking|DRUG: Nicotine Oral Pouch|DRUG: Nicotine Oral Pouch|OTHER: Questionnaire Administration|DRUG: Nicotine Oral Pouch|DRUG: Nicotine Oral Pouch|DRUG: Nicotine Oral Pouch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Injectable Cabotegravir Compared to TDF/FTC For PrEP in HIV-Uninfected Men and Transgender Women Who Have Sex With Men
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: Cabotegravir Oral Tablet|DRUG: TDF/FTC tablets|DRUG: Placebo for TDF/FTC tablets|DRUG: Placebo for cabotegravir oral tablet|DRUG: CAB LA|DRUG: Placebo for CAB LA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimers Disease|Dementia|Alzheimers Disease, Familial
Interventions: DRUG: E2814|DRUG: Lecanemab|DRUG: Matching Placebo (E2814)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Altering Colonic Microflora After Fiber (FOS) Consumption
Status: COMPLETED
Conditions: Hyperlipidemia|Cardiovascular Disease|Diet Therapy
Interventions: PROCEDURE: Diet with polyfructans and viscous fibers or soy protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Ketone Supplements and Substrate Oxidation and Physical Performance
Status: UNKNOWN
Conditions: Ketosis|Glucose Metabolism
Interventions: DIETARY_SUPPLEMENT: Ketone ester|DIETARY_SUPPLEMENT: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Ertugliflozin on Cardiac Function in Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes|Heart Failure
Interventions: DRUG: Ertugliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD19 & CD20 Bispecific CAR T Cells for Relapsed / Refractory B Cell Hematological Tumors
Status: RECRUITING
Conditions: B-Cell Lymphoblastic Leukemia/Lymphoma
Interventions: DRUG: CD19&CD20 bispecific CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics/Pharmacodynamics of NOX-H94 in the Human Endotoxemia Model
Status: COMPLETED
Conditions: Anemia of Chronic Disease
Interventions: DRUG: NOX-H94|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Treatment of Metastatic Melanoma With Autologous Lymphocytes and the Bispecific Antibody rM28
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: rM28|DRUG: autologous PBMCs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUX-Lung 4: BIBW 2992 (Afatinib) Phase I Trial in Advanced Non Small Cell Lung Cancer Patients & Phase II Trial in Non Small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BIBW 2992 MA2 40mg/day|DRUG: BIBW 2992 MA2 50mg/day|DRUG: BIBW 2992 MA2 20mg/day|DRUG: BIBW 2992 QD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide in Treating Patients With Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma of the Skin|Recurrent Skin Cancer
Interventions: DRUG: arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of a Custom Temporary Foot Orthosis for Plantar Fasciitis Treatment
Status: UNKNOWN
Conditions: Plantar Fasciitis
Interventions: DEVICE: Custom PFO|OTHER: Faux orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Neural Stimulation in Individuals With Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia|Schizo Affective Disorder
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reducing College Student Drinking by Integrating Self-Affirmation and Implementation Intentions
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: BEHAVIORAL: SA and II|BEHAVIORAL: SA and No II|BEHAVIORAL: No SA and II|BEHAVIORAL: No SA and No II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of a2 Infant Formula on Growth and Tolerance in Healthy Term Infants
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: a2 Platinum Premium Infant Formula Stage 1|DIETARY_SUPPLEMENT: Frisolac Infant Formula Stage 1 (Dutch Edition)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Physical Therapy on Improving Disc Height, Postural Stability, Pain and Function in Persons With Discogenic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Disk Prolapse
Interventions: PROCEDURE: Mckenzie Extension Protocol|PROCEDURE: Lumbar SNAGs|DEVICE: Inferential therapy|PROCEDURE: Heat Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Eight-Week Study of NLS-2 (Mazindol Extended Release) in Participants With Narcolepsy Type 1
Status: NOT_YET_RECRUITING
Conditions: Narcolepsy Type 1|Narcolepsy With Cataplexy
Interventions: DRUG: NLS-2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Examine The Safety, Tolerability And Pharmacokinetics Of PF-04958242 In Psychiatrically Stable Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-04958242|DRUG: PF-04958242|DRUG: PF-04958242|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions
Status: RECRUITING
Conditions: Cancer|Advanced Cancer|Advanced Solid Tumor|Mental Health Issue|Behavior Disorders
Interventions: OTHER: Drug-Drug Interaction Profile|OTHER: Drug-Gene Interaction Profile|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CORonary MICrovascular Angina (CorMicA)
Status: COMPLETED
Conditions: Angina, Stable|Coronary Vasospasm|Coronary Circulation|Coronary Syndrome|Microvascular Angina|Coronary Disease
Interventions: DIAGNOSTIC_TEST: Stratified medicine involving a diagnostic intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents
Status: TERMINATED
Conditions: Vaping|Nicotine Dependence
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Alprazolam Extended-Release Tablets 1 mg to Xanax XR Tablets 1 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Alprazolam Extended-Release Tablets 1 mg|DRUG: Xanax XR Tablets 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pertussis and Meningitis C Concomitant Vaccination in Adolescents
Status: COMPLETED
Conditions: Pertussis|Meningitis|Preventive Immunization; Meningitis|Immunization
Interventions: BIOLOGICAL: Meningococcal vaccine|DRUG: Pertussis containing vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Meibomian Glands Massage on Signs and Symptoms of Dry Eye
Status: COMPLETED
Conditions: MGD-Meibomian Gland Dysfunction
Interventions: PROCEDURE: Meibomian Glands Massage|PROCEDURE: Sham Meibomian Glands Massage|DEVICE: Meibomian Massage device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT