pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Evaluate Effect of Intranasal Teriparatide on Serum P1NP, a Biomarker of Bone Formation, in Postmenopausal Women With Low Bone Mass
Status: UNKNOWN
Conditions: Osteoporosis|Osteopenia
Interventions: DRUG: ZT-034 Low Dose Nasal Spray|DRUG: ZT-034 Mid Dose Nasal Spray|DRUG: ZT-034 High Dose Nasal Spray|DRUG: Teriparatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Twice Weekly Steroids and Exercise as Therapy for DMD
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy (DMD)
Interventions: DRUG: Prednisone|BEHAVIORAL: In-home Exercise Training|DRUG: Prednisone plus exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Ranolazine in Myotonia Congenita, Paramyotonia Congenita and Myotonic Dystrophy Type 1
Status: COMPLETED
Conditions: Myotonia Congenita|Paramyotonia Congenita|Myotonic Dystrophy 1
Interventions: DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block vs Erector Spinae Plane Block in Abdominal Hysterectomy
Status: COMPLETED
Conditions: Gynecologic Disease
Interventions: OTHER: No Block|PROCEDURE: Quadratus Lumborum Block Type III|PROCEDURE: Erector Spinae Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Application in Cervical Dilatation and Effacement Teaching
Status: NOT_YET_RECRUITING
Conditions: Virtual Reality|Educational
Interventions: BEHAVIORAL: virtual reality group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of CMR to Evaluate the Effect of Ivabradine on the Improvement of Left Ventricular Remodeling in STEMI Patients After Primary PCI
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: DRUG: Ivabradine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BGT007H Cells for the Treatment of Recurrent/Refractory Gastrointestinal Tumors
Status: RECRUITING
Conditions: Gastrointestinal Tumors
Interventions: BIOLOGICAL: First dose|BIOLOGICAL: Second dose|BIOLOGICAL: The third dose|BIOLOGICAL: The fourth dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GOUTMETALSAIN: Comparison of the Perception of Metallic Taste According to Lingual Locations in Healthy Volunteers
Status: COMPLETED
Conditions: Taste Disorders|Sensation Disorders|Taste, Metallic|Taste Disorder, Glossopharyngeal Nerve
Interventions: OTHER: swab with iron sulfate solution
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Unfolding the Wisdom Within: CFT for Adolescents in Residential Care
Status: RECRUITING
Conditions: Adolescent Behavior|Adolescent - Emotional Problem
Interventions: BEHAVIORAL: The Wise Adolescent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With CD19 CAR T-cells in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma
Status: COMPLETED
Conditions: Lymphoma Leukemia
Interventions: GENETIC: Welgenaleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Atacicept in Combination With Mycophenolate Mofetil Used to Treat Lupus Nephritis
Status: TERMINATED
Conditions: Lupus Nephritis
Interventions: DRUG: Atacicept|DRUG: Mycophenolate mofetil|DRUG: Placebo|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Symptom Management for Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: OTHER: Standard protocol|OTHER: Individualized protocol|OTHER: Sham acupuncture/Placebo moxa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Indacaterol 150 μg capsules|DRUG: Indacaterol 300 μg capsules|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tendon Repair and Physiotherapy in the Treatment of Small and Medium-sized Tears of the Rotator Cuff
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: PROCEDURE: Tendon repair with acromioplasty|PROCEDURE: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study, Called FINEGUST, to Learn More About How People With Chronic Kidney Disease and Type 2 Diabetes Are Treated and How the Introduction of New Treatment Options, Like Finerenone, Impacts Clinical Practice
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Kidney Disease|Type 2 Diabetes Mellitus
Interventions: DRUG: Finerenone (Kerendia, BAY 948862)|DRUG: Sodium-glucose cotransporter 2 inhibitors (SGLT2i)|DRUG: Glucagon-like peptide-1 receptor agonists (GLP 1 RA)|DRUG: Steroidal mineral corticoid receptor antagonists (sMRA)|DRUG: Non-steroidal mineral corticoid receptor antagonists (nsMRA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of HMPL-306 in Patients With IDH1 and/or IDH2 Mutation of Relapsed/Refractory Myeloid Leukemia/Neoplasms
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: HMPL-306
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis|Gonarthrosis
Interventions: DEVICE: Photomodulation Therapy with the Light-Aid system|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of an Oral Chemotherapy Teaching Tool to Improve Adherence in Patients With Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: BEHAVIORAL: Multinational Association of Supportive Care in Cancer Oral agent Teaching Tool|BEHAVIORAL: Standard of care consisting of standard counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixazomib With Pomalidomide, Clarithromycin and Dexamethasone in Treating Patients With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Myeloma
Interventions: DRUG: Clarithromycin|DRUG: Dexamethasone|DRUG: Ixazomib Citrate|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Two Regimen for Sedation for Transesophageal Echocardiography
Status: COMPLETED
Conditions: Hypotension
Interventions: DRUG: pethidin hydrochlorid, midazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Visualize Nociceptor Changes in Neuropathic Human
Status: UNKNOWN
Conditions: Chemotherapy-induced Peripheral Neuropathy|Peripheral Neuropathy
Interventions: DIAGNOSTIC_TEST: harmonic generation (HGM) microscopic methods.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Relapsed/Refractory Acute Myeloid Leukemia(AML)
Interventions: BIOLOGICAL: CART therapy in Acute myeloid leukemia(AML)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Quality of Recovery After General Anesthesia With Remimazolam
Status: NOT_YET_RECRUITING
Conditions: Anesthesia Recovery Period
Interventions: DRUG: Remimazolam besylate|DRUG: Propofol Injection Emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy, Safety, and Immunogenicity Study Comparing an Insulin Glargine Biosimilar Sansulin Log-G to Lantus
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: DRUG: Insulin Glargine Sansulin|DRUG: Insulin Glargine Pen Injector [Lantus]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Shared Decision Making in Patients With Osteoarthritis of the Hip and Knee
Status: COMPLETED
Conditions: Hip Osteoarthritis|Knee Osteoarthritis
Interventions: OTHER: Shared Decision Making Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Safety and Efficacy of RZL-012 in Subjects Seeking Fat Reduction in the Flanks
Status: COMPLETED
Conditions: Flank Mass
Interventions: DRUG: RZL-012|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Viome Nutritional Programs to Improve Clinical Outcomes for Mental Health Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health|Depression|Anxiety
Interventions: COMBINATION_PRODUCT: VIOME Precision Nutrition Program|DIETARY_SUPPLEMENT: VIOME-designed condition-based supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load
Status: COMPLETED
Conditions: SARS-CoV-2|COVID-19|Mouthwashes|Viral Load|Polymerase Chain Reaction|Coronavirus|Covid19|Saliva
Interventions: DRUG: Distilled Water|DRUG: 1% Povidone Iodine (PVP-I)|DRUG: 1.5% Hydrogen Peroxide (H2O2)|DRUG: 0.075% Cetylpyridinium Chloride (CPC)|DRUG: 0.1% Sodium Hypochlorite|OTHER: No rinse group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Hypnosis During Embryo Transfer Procedure on Clinical Pregnancy Rate for Patients Undergoing Assisted Reproductive Technology IVF or ICSI
Status: COMPLETED
Conditions: Infertility
Interventions: PROCEDURE: hypnosis during embryo transfer or usual transfer procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Xalatan, Travatan and Lumigan on Skin Pigmentation Near the Eye
Status: COMPLETED
Conditions: Glaucoma|Application Site Pigmentation Changes
Interventions: DRUG: latanoprost|DRUG: bimatoprost|DRUG: travoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Growth Hormone Treatment in Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DRUG: GH|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma
Status: COMPLETED
Conditions: Adult Anaplastic Astrocytoma|Adult Anaplastic Oligodendroglioma|Adult Diffuse Astrocytoma|Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Adult Mixed Glioma|Adult Oligodendroglioma|Recurrent Adult Brain Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Perifosine|DRUG: Temsirolimus|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Lynch Syndrome|Endometrial Cancer|Endometrial Hyperplasia|Mismatch Repair Deficiency|Microsatellite Instability
Interventions: DIAGNOSTIC_TEST: Immunohistochemical staining
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare Telmisartan (MICARDIS) 80 mg Versus Losartan (COZAAR) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy (AMADEO Study)
Status: COMPLETED
Conditions: Hypertension|Diabetic Nephropathies
Interventions: DRUG: telmisartan|DRUG: losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Swabs and Toothbrushes in Cleaning the Teeth of Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Dental Plaque|Gingivitis
Interventions: PROCEDURE: Cleaning of teeth with a toothbrush|PROCEDURE: Cleaning of teeth with a foam swab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Status: RECRUITING
Conditions: Depression|Bipolar I Disorder
Interventions: DRUG: Cariprazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Traditional Chinese Medicine Combined With Omeprazole in Patients With Non-erosive Reflux Disease
Status: UNKNOWN
Conditions: Non-erosive Reflux Disease
Interventions: DRUG: Treatment group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Creatine or Vitamin D Supplementation in Persons With Spinal Cord Injury Undergoing Resistance Training
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DIETARY_SUPPLEMENT: Creatine|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: [177Lu]Ludotadipep Treatment in Patients With Metastatic Castration-resistant Prostate Cancer.
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: [177Lu]Ludotadipep
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Traditional and Echocardiography Guided Fluid Management During Cytoreductive Surgery With HIPEC
Status: WITHDRAWN
Conditions: Peritoneal Neoplasms|Echocardiography Guided Fluid Management
Interventions: DEVICE: Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome
Status: COMPLETED
Conditions: Postural Orthostatic Tachycardia Syndrome
Interventions: BEHAVIORAL: Hybrid Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients.
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Placebo|DRUG: Intranasal Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of FOLFOX+Bevacizumab in Combination With Irinotecan in the Treatment of Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Oxaliplatin, 5FU/LV, Bevacizumab|DRUG: 5FU/LV, Oxaliplatin, Bevacizumab, Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence, Risk Factors, and Prognostic Factors of Intraabdominal Hypertension and Abdominal Compartment Syndrome in Critically Ill Surgical Patients in Ramathibodi Hospital
Status: UNKNOWN
Conditions: Intraabdominal Hypertension|Abdominal Compartment Syndrome
Interventions: DIAGNOSTIC_TEST: Intraabdominal pressure monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Protein-enriched Drink on Muscle Function
Status: UNKNOWN
Conditions: Contracture
Interventions: DIETARY_SUPPLEMENT: Protein-enriched drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Measure if There is Any Difference in How the Body Breaks Down or Inactivates Either Fluoxetine or LY2216684 When Both of These Medicines Are Given Together.
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: LY2216684|DRUG: Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tipifarnib, Gemcitabine, and Cisplatin in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: tipifarnib|DRUG: cisplatin|DRUG: gemcitabine hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Use of Specific Oral Hygiene Devices on Gingival Health Among Patients With Systemic Sclerosis
Status: RECRUITING
Conditions: Scleroderma Systemic
Interventions: DEVICE: Manual toothbrush|DEVICE: Manual toothbrush and water flosser (Philips Sonicare AirFloss)|DEVICE: Sonic toothbrush|DEVICE: Sonic toothbrush (Philips Sonicare) and water flosser (Philips Sonicare AirFloss)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Testing Trametinib as a Potential Targeted Treatment in Cancers With GNAQ or GNA11 Genetic Changes (MATCH-Subprotocol S2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: Trametinib Dimethyl Sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Controlled Trial of a Weight Loss Maintenance Program for Adults With Obesity: The WLM3P Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: WLM3P|BEHAVIORAL: Low-carb diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Rate of Pneumothorax in Severe Emphysema Secondary to Endoscopic Volume Reduction With Two-stage ZEPHYR® Valves Versus Endoscopic Volume Reduction With One-stage ZEPHYR® Valves
Status: RECRUITING
Conditions: COPD
Interventions: PROCEDURE: Endoscopic lung volume reduction in 2 stages|PROCEDURE: Endoscopic lung volume reduction in 1 stage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of SPL7013 Gel for Treatment of Bacterial Vaginosis (BV)
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: 0.5% SPL7013 Gel|DRUG: 1.0% SPL7013 Gel|DRUG: 3.0% SPL7013 Gel|OTHER: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Coordinated, Community-Based Medication Management Model for Home-Dwelling Aged in Primary Care
Status: COMPLETED
Conditions: Drug Therapy, Combination|Inappropriate Prescribing|Polypharmacy
Interventions: OTHER: Coordinated medication management model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Investigations of the Optimum Serum Bicarbonate Level in Renal Disease.
Status: COMPLETED
Conditions: Chronic Renal Insufficiency|Diabetes Mellitus
Interventions: DRUG: Sodium bicarbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Social Skills Training in Early Onset Psychosis
Status: UNKNOWN
Conditions: Schizophrenia|Schizoaffective Disorder|Psychosis NOS
Interventions: BEHAVIORAL: CBT + SST|BEHAVIORAL: Psychoeducation, habits and healthy lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Roxadustat in Participants With Anemia and Chronic Kidney Disease Not Requiring Dialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Anemia
Interventions: DRUG: Roxadustat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ablation Index Guided High Power Ablation for Pulmonary Vein Isolation in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Catheter Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Subjects That Are Taking Saxagliptin Added Onto Metformin XR Compared to Subjects Taking Metformin XR Alone
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin B12 Supplementation Study
Status: COMPLETED
Conditions: Vitamin B12 Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin B12|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Study to Evaluate the Efficacy of VR506 Using a New Inhaler for the Treatment of Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: VR506|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Vaccine RSVpreF In Pregnant Participants With HIV and Their Infants
Status: RECRUITING
Conditions: Respiratory Syncytial Virus
Interventions: BIOLOGICAL: RSVpreF vaccine|BIOLOGICAL: Placebp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Rimonabant Efficacy in Drug-NAive DiabEtic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Rimonabant (SR141716)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mildronate for Acute Ischemic Stroke
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: DRUG: infusion of mildronate|DRUG: placebo|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of Nitazoxanide on Chronic Hepatitis Patients
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Placebo|DRUG: Nitazoxanide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Two Doses of Pembrolizumab (MK-3475) Versus Docetaxel in Previously Treated Participants With Non-Small Cell Lung Cancer (MK-3475-010/KEYNOTE-010)
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Therapy for Scar Revision
Status: UNKNOWN
Conditions: Abdominoplasty Scar Revision
Interventions: OTHER: Platelet Rich Fibrin|OTHER: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Infection Using a Topical Gentamicin-Collagen Sponge in Diabetic Patients With An Uninfected Foot Ulcer
Status: TERMINATED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: gentamicin-collagen sponge|DRUG: placebo collagen sponge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Buen Provecho!: A Virtual Family-Based Intervention to Promote Health
Status: COMPLETED
Conditions: Health Behavior|Diet, Healthy|Childhood Obesity
Interventions: BEHAVIORAL: Virtual Family-Based Healthy Plate Club
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin icodec|DRUG: Placebo (insulin 287)|DRUG: Metformin|DRUG: Dipeptidyl peptidase-4 inhibitors|DRUG: Insulin glargine|DRUG: Placebo (insulin glargine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antidepressant Decision Aid for Major Depressive Disorder Patients
Status: COMPLETED
Conditions: Depression|Depressive Symptoms|Depressive Disorder, Major|Mood Disorders
Interventions: OTHER: Booklet of Scripts of Doctors|OTHER: Booklet of Scripts for Doctors and the Antidepressant Decision Aid for Major depressive disorder patients (ADAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessment of One-shot Cardiac-cervical-intracranial MRI in the Etiological Work up of Ischemic Stroke and Transient Ischemic Attacks
Status: UNKNOWN
Conditions: Ischemic Stroke|Transient Ischemic Attack
Interventions: OTHER: Current guidelines|OTHER: cc-MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Study to Evaluate the Effectiveness of Online Familiar Metacognitive Training (MCTf)
Status: NOT_YET_RECRUITING
Conditions: Psychosis|Mother-Child Relations
Interventions: BEHAVIORAL: Familiar Metacognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phenylephrine and Noradrenaline for Post Spinal Anesthesia Hypotension
Status: COMPLETED
Conditions: Adverse Anesthesia Outcome
Interventions: DRUG: phenylephrine|DRUG: Norepinephrine|DRUG: Bupivacaine|DRUG: Fentanyl|DRUG: Placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fludarabine / Total Body Irradiation Regimen for ALLO HCT in Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Adult Lymphoblastic Lymphoma
Interventions: DRUG: Fludarabine|PROCEDURE: Total Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Posttraumatic Stress Disorder|Traumatic Brain Injury
Interventions: BEHAVIORAL: Reconsolidation of Traumatic Memories (RTM)|BEHAVIORAL: Prolonged Exposure (PE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nike FuelBand on Exercise and Function in Claudicants; a Randomised Controlled Trial
Status: COMPLETED
Conditions: Peripheral Vascular Disease|Intermittent Claudication
Interventions: DEVICE: Nike FuelBand (NFB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radical Openness for Adolescents Pilot
Status: COMPLETED
Conditions: Anorexia Nervosa|Obsessive-Compulsive Disorder|Social Phobia|Depression, Anxiety
Interventions: BEHAVIORAL: Radically Open Dialectical Behavior Therapy (RO DBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I PK Study of Budesonide/Albuterol Delivered From PT027 in Healthy Chinese Participants.
Status: RECRUITING
Conditions: Healthy Volunteer
Interventions: COMBINATION_PRODUCT: budesonide/albuterol sulfate metered dose inhaleor (BDA MDI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AtriCure Exclusion of the LAA in Patients Undergoing Concomitant Cardiac Surgery
Status: COMPLETED
Conditions: Left Atrial Appendage Exclusion
Interventions: DEVICE: AtriCure LAA Exclusion System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness and Safety of Neoadjuvant Intravesical Mitomycin-C Instillation
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: intravesical mitomycin-C 40mg/20ml instillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intravenous Magnesium Infusion in Patients Undergoing Cardioversion of Atrial Fibrillation Trial
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Magnesium Sulfate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine Followed by Alemtuzumab in Treating Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: alemtuzumab|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dermatopharmacokinetic Trial of LEO 80185 Gel
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 80185 gel|DRUG: Dovobet(r) Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Investigating Whether Robot-assisted Surgery Can Reduce Surgical Complications Following Kidney Transplantation
Status: RECRUITING
Conditions: End Stage Renal Disease|Kidney Transplant; Complications
Interventions: PROCEDURE: Robot-Assisted Kidney Transplantation|PROCEDURE: Open Kidney Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Spinal Cord Stimulation in Patients With Refractory Angina Pectoris
Status: RECRUITING
Conditions: Refractory Angina Pectoris|Spinal Cord Stimulation
Interventions: DEVICE: Spinal Cord Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68-Ga-DOTATATE PET-CT Scan for Diagnosis of Primary and Metastatic Somatostatin Receptor-positive Neuroendocrine Tumors (NETs)
Status: COMPLETED
Conditions: Neuroendocrine Carcinoma
Interventions: DIAGNOSTIC_TEST: 68Ga-DOTATATE injection and PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Task Demands (Expt 2.1)
Status: ENROLLING_BY_INVITATION
Conditions: Basic Science: Visual Attention in Healthy Participants|Basic Science: Neural Representations of Location
Interventions: OTHER: Stimulus properties: task-defining feature
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of MEMOPTIC on Visual Field of Patients Followed for a Chronic Open-angle Glaucoma
Status: RECRUITING
Conditions: Open-angle Glaucoma|Visual Field
Interventions: DRUG: MEMOPTIC|DRUG: usual treatment of glaucoma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth
Status: COMPLETED
Conditions: Herpes Simplex
Interventions: DRUG: acyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus
Status: TERMINATED
Conditions: Cytomegalovirus Disease|Kidney Transplant Infection
Interventions: DRUG: Brincidofovir|DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses
Status: UNKNOWN
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Bepotastine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine and FR901228 in Treating Patients With Relapsed or Refractory Leukemia, Myelodysplastic Syndromes, or Myeloproliferative Disorders
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: decitabine|DRUG: romidepsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept Study to Evaluate the Safety and Immunomodulatory Effects of SCV 07 as Monotherapy or in Combination With Ribavirin in Noncirrhotic Subjects With Chronic Hepatitis C Who Have Relapsed
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: SCV-07
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Adaptive DBS Vs Conventional DBS in Patients With Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DEVICE: adaptive Deep Brain Stimulation|DEVICE: conventional Deep Brain Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Sofosbuvir-Based Regimens in the Treatment of Egyptian Patients With Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir|DRUG: Ribavirin|DRUG: Pegylated-interferon alfa-2a|DRUG: Simeprevir|DRUG: Daclatasvir|DRUG: Ritaprevir, paritaprevir, ombetasvir|DRUG: Sofosbuvir and Ledipasvir|DRUG: Salvage therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Anesthetic Concentration and Rebound Pain
Status: UNKNOWN
Conditions: Rebound Pain
Interventions: OTHER: Reduced concentration of local anesthetic (ropivacaine)|OTHER: Usual concentration of local anesthetic (ropivacaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study to Investigate Safety of KBP-7072 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: KBP-7072|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine
Status: UNKNOWN
Conditions: HIV Infections|Hypertension
Interventions: DRUG: candesartan|DRUG: lercanidipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial: Elbow Extension Versus Flexion Cast in Proximal Half Both Bone Forearm Fractures
Status: ENROLLING_BY_INVITATION
Conditions: Fracture of Radius and Ulna
Interventions: OTHER: Cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacologic and Clinical Testing of a D1 Agonist for Cognitive Enhancement in Neuropsychiatric Disorders
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: DAR-100A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of ExPreS in the Weaning of Patients in Invasive Mechanical Ventilation: a Multicenter Randomized Clinical Trial
Status: UNKNOWN
Conditions: Respiratory Insufficiency
Interventions: DIAGNOSTIC_TEST: ExPreS Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarkers in Women Receiving Chemotherapy & Celecoxib for Stage II or Stage III Breast Cancer Removable by Surgery
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: capecitabine|DRUG: celecoxib|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|GENETIC: gene expression analysis|GENETIC: polymorphism analysis|GENETIC: protein expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: imaging biomarker analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|PROCEDURE: needle biopsy|PROCEDURE: neoadjuvant therapy|PROCEDURE: radiomammography|PROCEDURE: ultrasound imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VZV Vaccine for Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Varicella Zoster Infection
Interventions: BIOLOGICAL: Zostavax|BIOLOGICAL: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Effectiveness Study of Paromomycin IM Injection (PMIM) for the Treatment of Visceral Leishmaniasis (VL) in Bangladesh
Status: COMPLETED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Paromomycin sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of ATG for Graft Versus Host Disease (GVHD) Prevention in Paediatric Patients Given an Unrelated Donor Stem Cell Transplantation
Status: UNKNOWN
Conditions: Paediatric Patients Affected by Haematological Malignancies and Eligible to Undergo HSCT From an Unrelated Volunteer
Interventions: DRUG: ATG Fresenius|DRUG: ATG Fresenius|DRUG: ATG Fresenius|DRUG: ATG Fresenius|DRUG: ATG Fresenius|DRUG: ATG Fresenius|DRUG: ATG Fresenius|DRUG: ATG Fresenius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Two Biphasic Insulin Regimens
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Premixed Human Isophane Insulin Suspension + Human Insulin Injection|DRUG: Premixed Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study in Adults With Cold Agglutinin Disease Previously Treated With SAR445088 or Never Treated With SAR445088
Status: ACTIVE_NOT_RECRUITING
Conditions: Autoimmune Haemolytic Anaemia
Interventions: DRUG: SAR445088
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of H.P. Acthar Gel to Treatment Regimen of Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: H.P. Acthar Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Versus Long-term Intravesical Instillation Chemotherapy for Recurrence After Nephroureterectomy for Upper Tract Urothelial Carcinoma
Status: UNKNOWN
Conditions: Intravesical Instillation
Interventions: DRUG: pirarubicin(THP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-ventilator Asynchrony During Mechanical Non-Invasive Assisted-ventilation in Pediatric Patients (NavPed-NI)
Status: COMPLETED
Conditions: Respiratory Failure|Mechanical Ventilation Complication
Interventions: OTHER: Non-invasive Ventilation under Pressure Support|OTHER: Non-Invasive ventilation under NAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Gliosarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Montanide ISA 51 VG|BIOLOGICAL: Sargramostim|BIOLOGICAL: SVN53-67/M57-KLH Peptide Vaccine|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OTX-DED for the Short-term Treatment of the Symptoms of Dry Eye Disease (DED)
Status: COMPLETED
Conditions: Dry Eye Syndromes|Eye Diseases
Interventions: DRUG: OTX-DED|DRUG: Controlled Insertion|DRUG: Collagen Punctal Plug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery
Status: COMPLETED
Conditions: Epilepsy
Interventions: OTHER: functional MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Temple University Employees With Musculoskeletal Conditions Receive Physical Therapy to Treat Limitations Early
Status: UNKNOWN
Conditions: Musculoskeletal Diseases
Interventions: BEHAVIORAL: Early Direct Access Physical Therapy|BEHAVIORAL: Physician management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH