pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pregabalin and Remifentanil - Analgesia and Ventilation
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Pregabalin|DRUG: Remifentanil|DRUG: sugar pill, saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Biliopancreatic Limb Lenght on Long-term Weight Loss After Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Weight Loss
Interventions: PROCEDURE: BP limb 70cm|PROCEDURE: BP limb 120cm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phamacokinetics and Safety Profiles of DA-5213 10mg in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DA-5213 10mg|DRUG: DA-5213-R 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caldolor Versus Caldolor Plus OFIRMEV in Total Knee or Hip Arthroplasty Surgeries
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Ofirmev|DRUG: Caldolor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tumour and HEalthy Tissues DOse-response and Radiosensitivity Assay
Status: TERMINATED
Conditions: Sarcoma|Rectal Carcinoma|Esophagus Cancer
Interventions: RADIATION: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis
Status: TERMINATED
Conditions: Alcoholic Cirrhosis|Iron Overload
Interventions: PROCEDURE: phlebotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: G-CSF for the Prevention of Febrile Neutropenia in Gynecologic Cancer Patients
Status: UNKNOWN
Conditions: Gynecologic Cancer|Myelosuppression Adult|Febrile Neutropenia|Chemotherapy-induced Neutropenia
Interventions: DRUG: Long-acting G-CSF|DRUG: Short-acting G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AXIOS™ Gastroenterostomy for Gastric Outlet Obstruction IDE
Status: NOT_YET_RECRUITING
Conditions: Gastric Outlet Obstruction
Interventions: DEVICE: AXIOS(TM) Stent and Electrocautery Enhanced Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chlorpheniramine Nasal Spray to Accelerate COVID-19 Clinical Recovery in an Outpatient Setting: ACCROS-I
Status: COMPLETED
Conditions: COVID-19|Symptoms and Signs|COVID-19 Pandemic|Coronavirus Disease 2019|Coronavirus Infections
Interventions: COMBINATION_PRODUCT: Chlorpheniramine Maleate 1% Nasal Spray|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Pain Management During Dilation and Evacuation
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Air Barrier System for the Reduction of Airborne Colony Forming Units During Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Air Barrier System|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Ataluren (PTC124™) in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ataluren|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)
Status: RECRUITING
Conditions: Cardiac Surgery
Interventions: BIOLOGICAL: Human platelets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Apnea Syndrome in Obese Women During Pregnancy
Status: COMPLETED
Conditions: Apnea, Obstructive Sleep|Pregnancy Complications|Pre-Eclampsia|Obesity
Interventions: DIAGNOSTIC_TEST: polysomnography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Virtual Reality, Cold-Vibration Due To Intravenous Catheterization on Pain, Fear and Anxiety on Children
Status: UNKNOWN
Conditions: Procedural Anxiety|Fear|Procedural Pain|Child, Only
Interventions: BEHAVIORAL: Virtual reality|BEHAVIORAL: Local cold-vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia
Status: COMPLETED
Conditions: Healthy Brain Perfusion
Interventions: OTHER: Acute Intermittent Hypoxia|OTHER: Sham Acute Intermittent Hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Avastin (Bevacizumab) Plus Herceptin (Trastuzumab) in Patients With Primary Inflammatory HER2-Positive Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Standard chemotherapy|DRUG: bevacizumab [Avastin]|DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients Receiving Induction With Liposomal Daunorubicin and Cytarabine (CPX-351) for Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute
Interventions: BEHAVIORAL: Outpatient Care Model|DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Infant Formula With Bovine Lactoferrin and Low Iron Concentration on Infant Health and Immune Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Health of Formula-fed Children|Infant Infections in Formula-fed Children|Iron Status of Formula-fed Children
Interventions: DIETARY_SUPPLEMENT: Formula with low iron concentration (2 mg/L) supplemented with bovine lactoferrin|DIETARY_SUPPLEMENT: Formula with low iron concentration (2mg/L) without lactoferrin|DIETARY_SUPPLEMENT: Formula with normal iron concentration (8 mg/L) without lactoferrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.
Status: COMPLETED
Conditions: Azoospermia, Nonobstructive|Oligozoospermia
Interventions: DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Dose-finding Study of JNJ-26481585 for Patients With Advanced Solid Malignancies and Lymphoma.
Status: COMPLETED
Conditions: Lymphoma|Neoplasms
Interventions: DRUG: JNJ-26481585
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-Sparing Protocol Comparing With Opioid-based Protocol After Bilateral Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Replacement|Postoperative Pain|Opioid Use
Interventions: DRUG: Opioid-Sparing Protocol|DRUG: Opioid-Based Patient Controlled Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections
Status: COMPLETED
Conditions: Intravitreal Injection|Ocular Rinse|Age-Related Macular Degeneration|Diabetic Macular Edema|Cystoid Macular Edema
Interventions: OTHER: OSDI questionnaire|OTHER: SPEEDII questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of the Safety and Efficacy of BAT5906 Injection
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: 2.5mg of BAT5906|DRUG: 4.0mg of BAT5906
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the H-coil Transcranial Magnetic Stimulation TMS Device - Safety and Feasibility Study for Acute and Maintenance Treatment in Major Depressive Episode
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: H-coil dTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Focused Assessed Echocardiography to Predict Fluid Responsiveness
Status: COMPLETED
Conditions: Hypovolemia|Surgery|Hypotension
Interventions: DIAGNOSTIC_TEST: Fluid challenge|DIAGNOSTIC_TEST: Focused transthoracic echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-A*01 Positive
Status: TERMINATED
Conditions: Breast Cancer|Cervical Cancer|Renal Cancer|Melanoma|Bladder Cancer
Interventions: DRUG: Aldesleukin|DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Anti-MAGE-A3 human leukocyte antigen serotype within HLA-A A serotype group (HLA-A* 01)-restricted T-cell receptor (TCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mirvetuximab Soravtansine in Combination With Bevacizumab, Carboplatin, Pegylated Liposomal Doxorubicin, Pembrolizumab, or Bevacizumab + Carboplatin in Participants With Folate Receptor Alpha (FRα) Positive Advanced Epithelial Ovarian Cancer, Primary Peritoneal, or Fallopian Tube Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Primary Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Mirvetuximab soravtansine|DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Pegylated Liposomal Doxorubicin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope
Status: COMPLETED
Conditions: Infiltrative Breast Cancer
Interventions: DRUG: Methylene blue (1%)|DRUG: Rhenium sulfure|PROCEDURE: Surgical procedure|PROCEDURE: Anatomo-pathologic procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery
Status: COMPLETED
Conditions: Pharmacological Action|Post Operative Pain|Opioid Use|Obesity, Morbid|Anesthesia Morbidity
Interventions: DRUG: Control Group|DRUG: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DRUG: 0.1 % Dexamethasone|DRUG: 0.1% Fluorometholone|DRUG: 1% Rimexolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Antiviral Activity of Clevudine in Patients Who Have Completed the L-FMAU-301 or L-FMAU-302 Trials
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: Clevudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pittsburgh Study Early Childhood
Status: RECRUITING
Conditions: Child Development|Child Language|Child Behavior Problem|Parenting|Parent Child Abuse
Interventions: BEHAVIORAL: Text4Baby or Bright by Text Referral|BEHAVIORAL: Nurture Program Warm Referral|BEHAVIORAL: Video Interaction Project|BEHAVIORAL: Family Check-UP|BEHAVIORAL: Smart Beginnings|BEHAVIORAL: Healthy Families America Warm Referral|BEHAVIORAL: Family Center Warm Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Onlay Versus Inlay Humeral Component in Reverse Total Shoulder Arthroplasty
Status: RECRUITING
Conditions: Arthritis Shoulder|Rotator Cuff Injuries
Interventions: DEVICE: Tornier Ascend Flex stem|DEVICE: Tornier Perform Stem Reverse+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Vagus Nerve Stimulation for the Prevention of Migraines
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DEVICE: gammaCore Sapphire active|DEVICE: gammaCore Sapphire Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Checkpoint Blockade in COVID-19 Pandemic
Status: TERMINATED
Conditions: COVID-19|Pneumonia, Viral
Interventions: DRUG: Tocilizumab|BIOLOGICAL: Pembrolizumab (MK-3475)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Minimally Invasive Micro-Sclerostomy (MIMS) in Glaucoma Surgery
Status: RECRUITING
Conditions: Glaucoma
Interventions: PROCEDURE: Minimally invasive microsclerostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PRT1419 in Patients With Relapsed/Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Multiple Myeloma|Acute Myeloid Leukemia|Non Hodgkin Lymphoma|Myelodysplastic Syndromes
Interventions: DRUG: PRT1419
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assistance Program for Outpatients Following an Allogeneic Hematopoietic Stem-cell Transplant
Status: UNKNOWN
Conditions: Hematologic Neoplasms
Interventions: OTHER: Outpatient assistance program for transplant patients (AMA-ALLO) based on a "navigation" nurse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rapid Normalization of Vitamin D Deficiency in PICU
Status: RECRUITING
Conditions: Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of PTSD Family Coach, a Mobile Phone App for Family Members of Individuals With PTSD
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: BEHAVIORAL: PTSD Family Coach Full|BEHAVIORAL: PTSD Family Coach Basic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT
Status: UNKNOWN
Conditions: Reversible Pulpitis|Dental Pulp Diseases
Interventions: BIOLOGICAL: NeoMTA|OTHER: ProRoot MTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Infant Formula on Resolution of Cow's Milk Allergy
Status: TERMINATED
Conditions: Milk Allergy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus GG|DIETARY_SUPPLEMENT: Extensively Hydrolyzed Casein Formula|DIETARY_SUPPLEMENT: Amino Acid Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Microwave Ablation Combined With Immunotherapy ± Anti-angiogenic Drugs in the Treatment of Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: Adebrelimab|DRUG: Apatinib|PROCEDURE: microwave ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Evaluation of Intranasal Nalmefene
Status: COMPLETED
Conditions: Pharmacodynamic
Interventions: DRUG: Nalmefene hydrochloride|DRUG: Naloxone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Chemotherapy and Tilelizumab in Stage III（cTNM-IIIA.IIIB）Non-small-cell Lung Cancer
Status: UNKNOWN
Conditions: Stage III|Non-small Cell Lung Cancer
Interventions: DRUG: tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Pilot Study - HA35 (Hyaluronan Molecular Weight 35) Dietary Supplement for Promoting Intestinal Health
Status: COMPLETED
Conditions: Gastrointestinal Microbiome
Interventions: DIETARY_SUPPLEMENT: Hyaluronan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tocilizumab vs CRRT in Management of Cytokine Release Syndrome (CRS) in COVID-19
Status: UNKNOWN
Conditions: Covid-19|SARS|Cytokine Storm|Cytokine Release Syndrome|Tocilizumab
Interventions: DRUG: Tocilizumab|OTHER: Standard of care|PROCEDURE: Continuous renal replacement therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury
Status: COMPLETED
Conditions: Brain Trauma
Interventions: DIETARY_SUPPLEMENT: Salovum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Nitrate and Physiological Aging
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Super Beets|DIETARY_SUPPLEMENT: Super Beets Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: RENOVATE Fibrosis:HFNC Versus NIPPV in Acute Respiratory Failure in Patients With Pulmonary Fibrosis
Status: TERMINATED
Conditions: Acute Respiratory Failure|Pulmonary Fibrosis
Interventions: DEVICE: High Flow Nasal Catheter|DEVICE: Noninvasive positive pressure ventilation (NIPPV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|OTHER: Pemetrexed (Chemotherapy)|OTHER: Nab-paclitaxel (Chemotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in COvid-19 Patients With iveRmectin (CORVETTE-01)
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Ivermectin 3 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy and Periodontal Therapy. A Clinical, Microbiological and Immunoenzymatic Analysis
Status: COMPLETED
Conditions: Periodontal Disease
Interventions: PROCEDURE: Residual pockets will be treated by laser + photosensitizer|PROCEDURE: Residual pockets will be treated only photosensitizer|PROCEDURE: Residual pockets will be treated scaling and root planing|PROCEDURE: laser + photosensitizer associated with scaling and root planing|PROCEDURE: furcation defects will be treated by scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on Cytokines in Sepsis in Children
Status: COMPLETED
Conditions: Sepsis, Severe
Interventions: DIETARY_SUPPLEMENT: probiotics( Lactobacillus acidophilus, lactobacillus delbruekii and lactobacillus fermentum 10 billions),|OTHER: maltose dissolved in distilled water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a Human Immunodeficiency Virus (HIV) Blood Screening Assay
Status: COMPLETED
Conditions: Healthy Donors|HIV Positive
Interventions: DEVICE: collection of follow-up sample based on PRISM HIV O Plus result
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluation of a Virtual Reality Tool for Identifying the Cognitive Functions of the Right Hemisphere in Patients With Glioma -TANGO
Status: UNKNOWN
Conditions: Brain Tumor|Virtual Reality
Interventions: DIAGNOSTIC_TEST: VIRTUAL REALITY application
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Patient Outcomes by Selective Implantation of the Zephyr EBV - Study
Status: COMPLETED
Conditions: COPD Patients With Homogeneous Emphysema|Endoscopic Lung Volume Reduction With Endobronchial Valve
Interventions: DEVICE: Endobronchial Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: STX-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DRUG: BG00011|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin vs Tolvaptan for Treatment of Autosomal Dominant Polycystic Kidney Disease
Status: UNKNOWN
Conditions: ADPKD
Interventions: DRUG: Metformin|DRUG: Tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment
Status: COMPLETED
Conditions: Anemia|Iron Deficiency|Neonatal Jaundice
Interventions: PROCEDURE: Early (≤30 seconds) cord clamping|PROCEDURE: Delayed (≤180 seconds) cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DCE MRI in Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Familial Pancreatic Cancer|Pancreatic Adenocarcinoma|Pancreatic Intraductal Papillary-Mucinous Neoplasm
Interventions: PROCEDURE: Dynamic Contrast-Enhanced Magnetic Resonance Imaging|DRUG: Ferumoxytol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Injection Therapy for Lateral Epicondylosis
Status: COMPLETED
Conditions: Tennis Elbow
Interventions: PROCEDURE: Dextrose prolotherapy|PROCEDURE: PrT-DMS|PROCEDURE: Platelet Rich Plasma injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Couples With Mild Male Factor Infertility
Status: UNKNOWN
Conditions: Subfertility
Interventions: DRUG: Merional|DRUG: Choriomon|PROCEDURE: IUI|PROCEDURE: Ovulation detection|DEVICE: Shepherd catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Resection Rate for Cold and Hot Snare Polypectomy for 5-15 mm Colorectal Polyps
Status: UNKNOWN
Conditions: Adenomatous Polyps
Interventions: PROCEDURE: Cold snare polypectomy|PROCEDURE: Hot snare polypectomy|PROCEDURE: Endoscopic margin observation method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: EMPOWER AUD Pivotal Trial
Status: RECRUITING
Conditions: Alcoholism|Alcohol Abuse|Alcohol Use Disorder
Interventions: DEVICE: Empower Neuromodulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Immune Globulin Intravenous (Human) To Treat Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Immune Globulin Intravenous [Human], 10% Caprylate/Chromatography Purified|DRUG: Albumin (Human) 25%, United States Pharmacopeia (USP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of PNEUMOSTEM® Treatment in Premature Infants With Bronchopulmonary Dysplasia
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia
Interventions: BIOLOGICAL: Human Umbilical Cord Blood Derived-Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ponatinib With Chemotherapy for Young Adults Ph Positive Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: ALL
Interventions: DRUG: Prednisone|DRUG: Vincristine|DRUG: Daunorubicin|DRUG: Prednisone|DRUG: Ponatinib|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: VP-16|DRUG: ARA-C:|DRUG: TIT|DRUG: Ponatinib|PROCEDURE: Autologous transplantation|PROCEDURE: Allo transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase IIA Study of BMS-512148 to Assess Safety, Exposure, and Biological Effects in Stable Type 2 Diabetic Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BMS-512148|DRUG: BMS-512148|DRUG: BMS-512148|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis|Multidrug Resistant Tuberculosis|Extensively-drug Resistant Tuberculosis
Interventions: DRUG: Linezolid|DRUG: Bedaquiline|DRUG: Levofloxacin|DRUG: Pyrazinamide|DRUG: Isoniazid|DRUG: Ethionamide|DRUG: Terizidone|DRUG: Moxifloxacin|DRUG: Kanamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isolating and Exploiting the Mechanisms That Link Breakfast and Human Health - Intervention
Status: COMPLETED
Conditions: Physical Activity|Postprandial Metabolism|Weight Loss
Interventions: OTHER: Carbohydrate Rich Breakfast|DIETARY_SUPPLEMENT: Whey protein enriched breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA (PROVIDE)
Status: COMPLETED
Conditions: Poliomyelitis|Tropical Enteropathy
Interventions: BIOLOGICAL: IPV vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Remimazolam Reduces Emergence Delirium in Preschool Children Undergoing Laparoscopic Surgery by Sevoflurane Anesthesia
Status: UNKNOWN
Conditions: Emergence Delirium
Interventions: OTHER: normal saline|DRUG: Bolus Remimazolam|DRUG: Continuous Infusion Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multicenter Clinical Study on the Optimal Treatment Protocol and Outcome of Cough Variant Asthma With Chinese and Western Medicine
Status: RECRUITING
Conditions: Cough Variant Asthma
Interventions: DRUG: traditional chinese medicine Xuanfei-Zhike formula|DRUG: inhaled corticosteroids (ICS) and long-acting β2-agonist (LABA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ischemic Stroke
Interventions: DRUG: conventional blood pressure control (labetalol, nicardipine)|DRUG: intensive blood pressure control (labetalol, nicardipine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Protein Supplementation With or Without Urolithin A During Single-leg Immobilization
Status: RECRUITING
Conditions: Healthy|Muscle Disuse Atrophy
Interventions: DIETARY_SUPPLEMENT: Protein supplement|DIETARY_SUPPLEMENT: Protein supplement with Urolithin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of Permethrin 5%, Fusidic Acid 1% and Synthomycine 5% for Demodex - Blepharitis
Status: UNKNOWN
Conditions: Inflammation of the Eyelids
Interventions: DRUG: Permethrin 5%|DRUG: Synthomycine 5%|DRUG: Fusidic Acid 1% M/R Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Descartes-11 in Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Descartes-11|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leveraging mHealth to Enable and Adapt CHW Strategies to Improve TB/HIV Patient Outcomes in SA
Status: ACTIVE_NOT_RECRUITING
Conditions: Adherence, Patient|TB|HIV/AIDS|Care Coordination
Interventions: OTHER: CHW mHealth patient intervention for trigger escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pneumatic Compression of the Legs to Reduce Fluid Demand in Minor Surgery
Status: COMPLETED
Conditions: ENT Surgery
Interventions: DEVICE: Intermittent pneumatic compression (IPC)|DEVICE: IPC - placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Utilization of Target Ranges to Treat Parkinson's Disease With the PKG
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DEVICE: Personal KinetiGraph® (PKG®) Watch|DEVICE: Personal KinetiGraph® (PKG®) Report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects on Pain and Function of Orthopedic Manual Therapy in Patients With Painful Disc Displacement With Reduction
Status: COMPLETED
Conditions: Temporomandibular Disorder|Manual Therapy
Interventions: OTHER: Therapeutic exercise|OTHER: Orthopedic manual therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial Comparing the Quality of Life, Tolerability and Toxicity of PEG Intron With INTRON® A in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pegylated Interferon|DRUG: Interferon-alpha2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Assessment of Circulatory Compromise With Ox-Imager Using a Vascular Occlusion Test Protocol
Status: UNKNOWN
Conditions: Circulatory; Change
Interventions: DEVICE: The Ox-Imager Mini (Desaturation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Lactate-Containing Vaginal Lubricant on Sexual Dysfunction in Young Breast Cancer Survivors
Status: COMPLETED
Conditions: Sexual Dysfunction|Breast Cancer Survivors
Interventions: DRUG: Lactate-containing vaginal lubricant|DRUG: Placebo vaginal lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Impairment Study: Pharmacokinetics in Healthy and Hepatically Impaired Subjects
Status: COMPLETED
Conditions: Pain|Hepatic Impairment
Interventions: DRUG: SKY0402 300mg in healthy patients|DRUG: SKY0402 300mg in hepatically impaired patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nicotinamide on Retinal Ganglion Cell Functions in Glaucoma Patients
Status: RECRUITING
Conditions: Glaucoma
Interventions: OTHER: Nicotinamide(Mitovita)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Dexmedetomidine to Decrease Postoperative Nausea and Vomiting and Shivering.
Status: COMPLETED
Conditions: Intrathecal Dexmedetomidine
Interventions: DRUG: Dexmedetomidine Injection [Precedex]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia
Status: UNKNOWN
Conditions: Dyspepsia
Interventions: DRUG: Rebamipide|DRUG: Placebo (for Esomeprazole)|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wait List Controlled Trial of Brief ACT and Brief MBSR-informed Group Interventions for Anxiety in a University Setting
Status: COMPLETED
Conditions: Anxiety|Stress
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT) group based intervention|BEHAVIORAL: Mindfulness based stress reduction (MBSR) informed brief mindfulness skills group intervention|BEHAVIORAL: Wait list Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Y-3 Injection Through Skull Bone Marrow in the Treatment of Acute Malignant Middle Cerebral Artery Infarction (SOLUTION)
Status: COMPLETED
Conditions: Stroke, Acute Ischemic
Interventions: PROCEDURE: Intracalvaria bone marrow injection|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluticasone/Salmeterol (FP/SM) Versus Double the Dose Fluticasone (FP) in Patients With Mild to Moderate Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone/salmeterol|DRUG: fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome (PCOS)|Overweight|Obesity
Interventions: DRUG: Metformin-GLP-1 Receptor Agonist|DRUG: Metformin-Oral Contraceptive(OC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen
Status: UNKNOWN
Conditions: Fibrosis
Interventions: DRUG: pentoxifylline with tocopherol|OTHER: pentoxifylline+tocopherol + Hyperbaric Oxygen Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Non-Alcoholic Fatty Liver|Non-Alcoholic Steatohepatitis
Interventions: DIETARY_SUPPLEMENT: Vitamin E [(all-rac)-α-tocopheryl acetate]|DIETARY_SUPPLEMENT: Omega-3 fatty acid (DHA EE)|COMBINATION_PRODUCT: Omega-3 fatty acid (DHA EE) & Vitamin E [(all-rac)-α-tocopheryl acetate]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis
Status: COMPLETED
Conditions: Degenerative Arthritis|Knee Osteoarthritis
Interventions: BIOLOGICAL: JOINTSTEM|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Urtica Comp. Gel for Prevention and Therapy of Radiation Dermatitis
Status: COMPLETED
Conditions: Radiation Dermatitis
Interventions: DRUG: Urtica comp. gel|DRUG: institutional standard skin care "Excipial-Hydrolotion"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rifaximin Prophylaxis for Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome in Cirrhotic Patients
Status: COMPLETED
Conditions: Ascites Infection
Interventions: DRUG: Rifaximin 550 milligram Oral Tablet [XIFAXAN]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes in a Comparison of Manual Penetrating Keratoplasty and the IntraLase® Enabled Keratoplasty
Status: UNKNOWN
Conditions: Keratoconus
Interventions: PROCEDURE: Penetrating keratoplasty with IntraLase|PROCEDURE: Penetrating keratoplasty with vacuum trephine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR)
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin Glargine|DRUG: Metformin|DRUG: Prandial insulin|DRUG: Exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dose-Response and Pharmacokinetics of Gabapentin Enacarbil (GEn [XP13512 / GSK1838262]) in Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: GEn (XP13512/GSK1838262)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ReVeRA-201: Etripamil in Atrial Fibrillation, Phase 2
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Etripamil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eversense and Dexcom G5: Efficacy and Accuracy in Type 1 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Dexcom G5-Eversense|DEVICE: Eversense-Dexcom G5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Drug-induced Repolarization ECG Changes
Status: UNKNOWN
Conditions: Long QT Syndrome|ADHD|Depression|Death|Death, Sudden, Cardiac|Romano-Ward Syndrome|Pathologic Processes|Heart Arrest|Electrocardiogram: Electrical Alternans|Heart Diseases|Cardiovascular Diseases|Death, Sudden|Arrhythmias, Cardiac|Heart Defects, Congenital|Cardiovascular Abnormalities|Congenital Abnormalities|Genetic Disease|Genetic Syndrome|Qt Interval, Variation in|Psychiatric Disorder
Interventions: DIAGNOSTIC_TEST: Electrocardiogram examination|DIAGNOSTIC_TEST: Echocardiography|PROCEDURE: Blood Samples|BEHAVIORAL: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Ketamine as an Antidepressant
Status: UNKNOWN
Conditions: Major Depressive Episode
Interventions: DRUG: Ketamine|DRUG: Saline or Midazolam (active placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circumferential Versus Ganglionated Plexi Ablation for Atrial Fibrillation (AF)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: GP ablation|PROCEDURE: PV isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Carob and Probiotics on Acute Diarrhea in Children
Status: UNKNOWN
Conditions: Diarrhea
Interventions: DIETARY_SUPPLEMENT: Mineral solution|DIETARY_SUPPLEMENT: Carob powder with probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DEB Versus 2nd Generation DES in Patients With In-Scaffold Restenosis of Bioresorbable Vascular Scaffold
Status: WITHDRAWN
Conditions: Coronary Artery Disease|Coronary Restenosis
Interventions: DEVICE: PCI for in-bioresorbable scaffold stenosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Use in Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Metformin|DRUG: Conventional DMARDs|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 3D Printed Implant for Management of Gummy Smile Through VISTA Technique
Status: NOT_YET_RECRUITING
Conditions: Management of Gummy Smile
Interventions: PROCEDURE: VISTA technique and 3D printed PMMA implant|PROCEDURE: VISTA technique and 3D printed PEEK implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Anaesthesia With Chloroprocaine HCl 1% for Elective Lower Limb Procedures of Short Duration.
Status: COMPLETED
Conditions: Short Duration Lower Limb Surgery Via Spinal Anaesthesia
Interventions: DRUG: Chloroprocaine HCl 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Does the Insula Control Smoking-Induced Dopamine Release? A TMS/[11C]-PHNO Study in Humans.
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation|OTHER: repetitive Transcranial Magnetic Stimulation Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ExAblate (MRgFUS) Treatment of Metastatic Bone Tumors for the Palliation of Pain
Status: COMPLETED
Conditions: Bone Metastases|Multiple Myeloma
Interventions: DEVICE: ExAblate MRfFUS|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Autoimmune Diseases|Systemic Inflammatory Process|Knee Pain Chronic|Osteoarthritis|Rheumatoid Arthritis
Interventions: DRUG: Fish Oil|DIETARY_SUPPLEMENT: Vitamin D|OTHER: placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Immunogenicity of Zika Vaccine mRNA-1893 in Healthy Flavivirus Seropositive and Seronegative Adults
Status: COMPLETED
Conditions: Zika Virus
Interventions: BIOLOGICAL: mRNA-1893|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION