pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase 1/2 Study of CF102 in Patients With Chronic Hepatitis C Genotype 1
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: CF 102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Paclitaxel in Treating Patients With Metastatic or Unresectable Cancer
Status: UNKNOWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: oxaliplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery
Status: COMPLETED
Conditions: Postoperative Wound Infection Superficial Incisional|Postoperative Wound Infection Deep Incisional Surgical Site
Interventions: DRUG: D-PLEX|PROCEDURE: Open heart surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Intravenous (IV) Cergutuzumab Amunaleukin and Atezolizumab in Combination in Participants With Locally Advanced and/or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Atezolizumab|DRUG: Cergutuzumab Amunaleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Nilotinib in Adult Patients With Imatinib-resistant or Imatinib-intolerant Chronic Myelogenous Leukemia (CML), or Relapse/Refractory Ph+ Acute Lymphoblastic Leukemia (ALL) (Extension Study)
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Cord Blood Mononuclear Cells for Bronchopulmonary Dysplasia in Very Preterm Neonates
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia|Premature|Neonatal Death
Interventions: OTHER: Autologous Umbilical Cord Blood Mononuclear Cells Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Olaparib in Treating Patients With Newly Diagnosed BRCA-Mutant Ovarian, Primary Peritoneal, or Fallopian Cancer Before Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: BRCA-Mutated Ovarian Carcinoma|BRCA1 Gene Mutation|BRCA2 Gene Mutation|High Grade Fallopian Tube Serous Adenocarcinoma|High Grade Ovarian Serous Adenocarcinoma|Primary Peritoneal High Grade Serous Adenocarcinoma|Stage III Fallopian Tube Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Primary Peritoneal Cancer AJCC v8|Stage IIIA Fallopian Tube Cancer AJCC v8|Stage IIIA Ovarian Cancer AJCC v8|Stage IIIA Primary Peritoneal Cancer AJCC v8|Stage IIIA1 Fallopian Tube Cancer AJCC v8|Stage IIIA1 Ovarian Cancer AJCC v8|Stage IIIA2 Fallopian Tube Cancer AJCC v8|Stage IIIA2 Ovarian Cancer AJCC v8|Stage IIIB Fallopian Tube Cancer AJCC v8|Stage IIIB Ovarian Cancer AJCC v8|Stage IIIB Primary Peritoneal Cancer AJCC v8|Stage IIIC Fallopian Tube Cancer AJCC v8|Stage IIIC Ovarian Cancer AJCC v8|Stage IIIC Primary Peritoneal Cancer AJCC v8|Stage IV Fallopian Tube Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Primary Peritoneal Cancer AJCC v8|Stage IVA Fallopian Tube Cancer AJCC v8|Stage IVA Ovarian Cancer AJCC v8|Stage IVA Primary Peritoneal Cancer AJCC v8|Stage IVB Fallopian Tube Cancer AJCC v8|Stage IVB Ovarian Cancer AJCC v8|Stage IVB Primary Peritoneal Cancer AJCC v8
Interventions: DRUG: Chemotherapy|DRUG: Olaparib|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secretory Otitis Media in Adenoids Hypertrophy Patients
Status: UNKNOWN
Conditions: Otitis Media With Effusion
Interventions: PROCEDURE: Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Tigilanol Tiglate in Combination With Pembrolizumab in Stage IIIB to IV M1c-melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: tigilanol tiglate|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Intradialytic Hypertension
Status: COMPLETED
Conditions: Renal Failure Chronic Requiring Hemodialysis|Haemodialysis-induced Symptom|Hypertension
Interventions: OTHER: Mindfulness Meditation|OTHER: Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics and Pharmacodynamics of BI 695500 vs. Rituximab as First Line-treatment in Patients With Low Tumor Burden Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Follicular
Interventions: DRUG: BI 695500|DRUG: MabThera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study Comparing Oral Contraceptive Containing Norgestimate or Desogestrel for Acne Treatment
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Ethinyl estradiol/Norgestimate (EE/NGM)|DRUG: Ethinyl estradiol/Desogestrel (EE/DSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DIAbetes TEam and Cgm in Managing Hospitalised Patients With Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Dexcom G6 Continuous Glucose Monitoring System (Dexcom Inc., San Diego, USA)|DEVICE: FreeStyle Precision Pro Glucometer for glucose POC testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Vitamin A on Multiple Sclerosis (MS)
Status: UNKNOWN
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: vitamin A|DRUG: Drug: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Consumption of a Fermented Milk on Common Infections in Children Aged 3-6 Years, Attending Day Care Centers
Status: COMPLETED
Conditions: Common Infectious Diseases
Interventions: OTHER: 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®)|OTHER: 2-Non fermented dairy product (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multiple Ascending Dose Trial of CVL-231 in Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: CVL-231|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Elucidating the Mechanism of Remission of Type 2 Diabetes in Morbid Obese Patients After Bariatric Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Morbid Obesity|Type2 Diabetes
Interventions: PROCEDURE: Laparoscopic Sleeve Gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Individualised Homoeopathic Treatment Using the Grant Bentley Method in Premenstrual Syndrome
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: OTHER: Individualised Homoeopathic Remedy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Pharmacokinetics, Safety, and Tolerability of Rotigotine in Healthy Korean Subjects
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Rotigotine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of the Use of FeelWell™ Compression Garment on Individuals With a BMI ≥35
Status: UNKNOWN
Conditions: Obesity|Obesity, Abdominal|Mobility Limitation|Quality of Life|Back Pain|Pain, Chronic|Weight Change, Body|Inactivity|Exercise|Body Composition|Redundant Skin
Interventions: DEVICE: FeelWell™ Compression garment|BEHAVIORAL: Increase Mobility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Lymphoma|Non-Hodgkin Lymphoma
Interventions: DRUG: Glofitamab|DRUG: Obinutuzumab (G)|DRUG: Rituximab (R)|DRUG: Tocilizumab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Polatuzumab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Clinical Pilates Exercises on Individuals With Lumbar Disc Herniation
Status: UNKNOWN
Conditions: Lumbar Disc Herniation
Interventions: OTHER: Clinical pilates exercises|OTHER: physiotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip
Status: TERMINATED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: Fasinumab|DRUG: Naproxen|DRUG: Diclofenac|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Three Calcium Supplements
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: calcium phosphate|DIETARY_SUPPLEMENT: Tricalcium Phosphate|DIETARY_SUPPLEMENT: Calcium carbonate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CAT-1004 Biomarkers in Healthy Subjects
Status: COMPLETED
Conditions: Assessment of Mechanistic Blood Biomarkers in Healthy Humans
Interventions: DRUG: CAT-1004|DRUG: Salsalate + DHA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Bexagliflozin in Type 2 Diabetes Mellitus Patients With Moderate Renal Impairment
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Bexagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Sonelokimab for the Treatment of Patients With Active Moderate to Severe Hidradenitis Suppurativa
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Sonelokimab (M1095)|DRUG: Adalimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Pharmacoepidemiological Evaluation of Autophagy Inhibition in Treatment of HCV Patients Resistant to Standard Therapy. Pilot Study"
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: 150 mg/daily chloroquine compare to placebo for 12 week|DRUG: Chloroquine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACURATE™ Transapical Aortic Bioprosthesis for Implantation in Patients With Severe Aortic Stenosis (2010-01)
Status: COMPLETED
Conditions: Aortic Symptomatic Stenosis
Interventions: DEVICE: ACURATE TA™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraoperative PEEP Individualization According to Driving Pressure in Major Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Mechanical Ventilation Complication
Interventions: PROCEDURE: Peep individualization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Extract of Ginkgo Biloba and Tardive Dyskinesia
Status: COMPLETED
Conditions: Tardive Dyskinesia|Schizophrenia
Interventions: DRUG: Extract of Ginkgo Biloba (EGb-761 capsules)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DIETARY_SUPPLEMENT: Antioxidant supplement|OTHER: Diabetes treatment|DRUG: Regular Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Does Pregabalin Improve Post-operative Pain After C-section Delivery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Pregabalin 150mg|DRUG: Placebos|DRUG: Pregabalin 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy to All Residual Lesions After Chemoimmunotherapy
Status: RECRUITING
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: RADIATION: Radiotherapy to all residual lesions|DRUG: Chemoimmunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estradiol Vaginal Softgel Capsules in Treating Symptoms of Vulvar and Vaginal Atrophy in Postmenopausal Women
Status: COMPLETED
Conditions: Vulvovaginal Atrophy|Menopause|Dyspareunia|Painful Intercourse
Interventions: DRUG: Estradiol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HABIT-ILE in Adults With Chronic Stroke (HABIT-ILE Stroke)
Status: UNKNOWN
Conditions: Stroke
Interventions: BEHAVIORAL: Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)|BEHAVIORAL: Regular care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of TruNatomy and HyFlex EDM Instrumentation on Postoperative Pain
Status: UNKNOWN
Conditions: Endodontically Treated Teeth
Interventions: DEVICE: TruNatomy Files|DEVICE: HyFlex EDM Files
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ezetimibe Combination Therapy for Patients With Atherosclerotic Cardiovascular Disease; Randomized Comparison of LDL-cholesterol Targeting <70 Versus <55mg/dL; Ez-PAVE Trial
Status: RECRUITING
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Ezetimibe/Statin Combination therarpy (ezetimibe plus rosuvastatin)|DRUG: Statin monotherapy (rosuvastatin or atorvastatin)|DRUG: Ezetimibe/Statin Combination therarpy (ezetimibe plus rosuvastatin)|DRUG: Statin monotherapy (rosuvastatin or atorvastatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Roles of MRI, DYNEELAX and Stress X-ray in First-Line Diagnosis of Cruciate Ligament Injury
Status: RECRUITING
Conditions: Knee Injuries|Anterior Cruciate Ligament Injuries|Knee Ligament Injury|Knee Arthritis
Interventions: DIAGNOSTIC_TEST: knee stability test (DYNEELAX)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of Dexmedetomidine in Severe Traumatic Brain Injury
Status: WITHDRAWN
Conditions: Traumatic Brain Injury
Interventions: DRUG: Precedex|DRUG: Propofol|DRUG: Fentanyl|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Capecitabine (Xeloda) as First-Line Chemotherapy in Participants With Metastatic Nasopharyngeal Cancer
Status: COMPLETED
Conditions: Nasopharyngeal Cancer
Interventions: DRUG: Capecitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hot Flashes|Breast Cancer
Interventions: DRUG: solifenacin|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Computer Assisted Instrument Guidance (CAIG) For Arterial Line Placement
Status: COMPLETED
Conditions: Arterial and Midline Catheterization
Interventions: DEVICE: Computer Assisted Instrument Guidance (CAIG), which supplements existing ultrasound capabilities.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Associations Between Diabetes, Arterial Stiffness and Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?
Status: UNKNOWN
Conditions: Coronary Artery Disease|Arteriosclerosis|Carotid Stenosis|Thrombosis|Aortic Aneurysm, Abdominal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extracorporeal Shockwave Therapy for Knee Osteoarthritis
Status: COMPLETED
Conditions: Shockwave Therapy|Knee Osteoarthritis
Interventions: DEVICE: shockwave therapy|OTHER: PT|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Speed Endurance Training on Agility and Functional Performance in Soccer Players
Status: RECRUITING
Conditions: Sports Physical Therapy
Interventions: OTHER: speed endurance production (SEP) training along with conventional training.|OTHER: conventional training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pregabalin and Alpha-lipoic Acid Combination Versus Each Monotherapy in Patients With Diabetic Peripheral Neuropathy
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathy
Interventions: DRUG: Pregabalin 150mg + Alpha-lipoic acid 480mg|DRUG: Pregabalin 150mg|DRUG: Alpha-Lipoic Acid 480mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sutures for Treatment of Knee Arthroscopy
Status: COMPLETED
Conditions: Knee Arthroscopy|Suture
Interventions: DEVICE: 3.0 monocryl suture|DEVICE: 3.0 nylon suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cosentyx (Secukinumab) for the Treatment of Adult Onset Pityriasis Rubra Pilaris
Status: COMPLETED
Conditions: PITYRIASIS RUBRA PILARIS
Interventions: DRUG: Cosentyx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mediterranean Diet in Obese Adolescents With Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: OTHER: Mediterranean diet|OTHER: Control diet: Low fat diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psychosocial eHealth in Advanced Lung Cancer
Status: RECRUITING
Conditions: Lung Cancer, Nonsmall Cell, Stage IIIA|Lung Cancer Non-Small Cell Stage IIIB|Lung Cancer Non-Small Cell Stage III|Lung Cancer Stage IV|Lung Cancer
Interventions: BEHAVIORAL: E-health ecosystem of stepped psychosocial care|BEHAVIORAL: Usual psychosocial care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 28-Day Repeat-Dose, Dose Escalation Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men
Status: UNKNOWN
Conditions: Healthy Men|Male Contraception
Interventions: DRUG: Placebo|DRUG: 11β-methyl-nortestosterone-dodecylcarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Multinational Survey-based Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Cardiologists
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease (ASCVD)|Chronic Kidney Disease (CKD)
Interventions: OTHER: No treatment given
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety & Efficacy of Peginesatide for the Treatment of Anemia in Participants With Chronic Renal Failure Not on Dialysis
Status: COMPLETED
Conditions: Chronic Renal Failure|Chronic Kidney Disease|Anemia
Interventions: DRUG: peginesatide|DRUG: peginesatide|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS)
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: DRUG: sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Grape Juice Consumption on the Parameters of Oxidative Stress and Muscle Fatigue in Judo Athletes
Status: COMPLETED
Conditions: Oxidative Stress|Muscle Fatigue|Polyphenol|Free Radical Oxidation of Tissue
Interventions: DIETARY_SUPPLEMENT: Grape juice|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized, Double-blind Comparison of Morphine and Sufentanil for Prehospital Traumatic Severe Acute Pain
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Sufentanil|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Quadrivalent Influenza Virus Vaccine in Healthy People Aged 3 Years and Older
Status: COMPLETED
Conditions: Quadrivalent Influenza Virus Vaccine
Interventions: BIOLOGICAL: One dose of Quadrivalent Influenza Virus Vaccine|BIOLOGICAL: One dose of Quadrivalent Influenza Virus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Rosuvastatin|DRUG: Simvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Defining the Best Approach to Block the Pain After Knee Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Fascia Iliaca Block|PROCEDURE: Femoral Block (with stimulating catheter)|PROCEDURE: Femoral Block (without stimulating catheter)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Apical Suspension Repair for Vault Prolapse In a Three-Arm Randomized Trial Design
Status: ACTIVE_NOT_RECRUITING
Conditions: Visceral Prolapse
Interventions: PROCEDURE: Open, Robotic, or Laparoscopic|PROCEDURE: Transvaginal Native Tissue Repair|PROCEDURE: Uphold™ LITE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Peripheral Arterial Resistive Index in Evaluation of Tissue Perfusion in Patients With Septic Shock
Status: COMPLETED
Conditions: Shock, Septic
Interventions: DIAGNOSTIC_TEST: hemodynamic monitoring|DIAGNOSTIC_TEST: resistive index|DIAGNOSTIC_TEST: Pleth variability index
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pragmatic Delivery of Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes type1|Diabetes Mellitus, Type 1|Diabetes, Autoimmune|Diabetes Mellitus|Distress, Emotional
Interventions: BEHAVIORAL: ReCharge|BEHAVIORAL: TakeCharge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.
Status: COMPLETED
Conditions: Hip Fractures|Hypotension on Induction|Intraoperative Hypotension|Acute Kidney Injury|Myocardial Ischemia|Wound Infection|Perioperative/Postoperative Complications
Interventions: DEVICE: Continuous non-invasive blood pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma
Status: RECRUITING
Conditions: Recurrent Glioblastoma
Interventions: BIOLOGICAL: Dendritic Cell Tumor Cell Lysate Vaccine|BIOLOGICAL: Pembrolizumab|OTHER: Placebo Administration|DRUG: Poly ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Na-APR-1 (M74)/Alhydrogel® Co-administered With Na-GST-1/Alhydrogel in Brazilian Adults
Status: COMPLETED
Conditions: Hookworm Infection|Hookworm Disease
Interventions: BIOLOGICAL: Na-GST-1/Alhydrogel plus GLA-AF|BIOLOGICAL: Na-APR-1 (M74)/Alhydrogel|BIOLOGICAL: Na-APR-1 (M74)/Alhydrogel plus GLA-AF|BIOLOGICAL: Sterile Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Leptomeningeal Metastases
Interventions: RADIATION: Involved-field Photon Radiation Therapy|RADIATION: Proton Craniospinal Irradiation (CSI)|OTHER: Neurocognitive Assessment|OTHER: MDASI-BT and MDASI-SP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis
Status: COMPLETED
Conditions: Neuroborreliosis, Borrelia Burgdorferi
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Intravenous ACU193 in Participants With Early Alzheimer's Disease (ALTITUDE-AD)
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: ACU193|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Interaction Study to Look at the Effects of Brivaracetam on Phenytoin When Taken Together in 15 Adult Patients With Epilepsy.
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam (ucb34714)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT for Gambling and Naltrexone, Using Use Eye-tracking Analysis to Predict Treatment Response
Status: UNKNOWN
Conditions: Eye Tracking|Gambling Disorder|Naltrexone
Interventions: DRUG: Naltrexone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Acetylsalicylic Acid on Immunoparalysis Following Human Endotoxemia
Status: COMPLETED
Conditions: Endotoxemia
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ketamine as a Supplement to Local Anesthesia for Minor Procedures
Status: RECRUITING
Conditions: Pain, Procedural|Minor Laceration|Abscess
Interventions: DRUG: Ketamine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Radiodermatitis in Breast and Head and Neck Cancer Patients in Cyprus
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer|Breast Cancer
Interventions: OTHER: MEDISKIN cream|OTHER: Panthenol cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reach Out 2: Emergency Department-Initiated Hypertension Mobile Health Intervention Connecting Multiple Health Systems
Status: RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: Self-Measured Blood Pressure Monitoring|BEHAVIORAL: Physician appointment and transportation scheduling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iAssist vs. Conventional Instrumentation in Total Knee Arthroplasty Using the Persona Knee System Among Patients With BMI>=30: Radiographic, Clinical and Economic Outcomes
Status: UNKNOWN
Conditions: Primary Knee Replacement
Interventions: PROCEDURE: iAssist Technique using Persona system vs. the conventional technique using Persona system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TPVB, PECSB, ESPB for Postmastectmy Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Ultrasound guided block|DRUG: IV morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Psilocybin for the Treatment of Cluster Headache
Status: COMPLETED
Conditions: Cluster Headache
Interventions: DRUG: 0.143 mg/kg Psilocybin or 10 mg Psilocybin|DRUG: 0.0143 mg/kg Psilocybin or 1 mg Psilocybin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA
Status: TERMINATED
Conditions: Carotid Stenosis
Interventions: DEVICE: NexStent Carotid Stent System (Monorail Delivery System)|DEVICE: FilterWire EZ™ Embolic Protection System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chorion Membrane With Photobiostimulation ,Chorion Membrane & SCTG in Treating Isolated RT 2 Recession Defects
Status: NOT_YET_RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: Test group 1 - CM+LLLT+VISTA|PROCEDURE: Test group 2 - CM+VISTA|PROCEDURE: Control group - SCTG+VISTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Azacitidine and Sargramostim as Maintenance Treatment for Poor-Risk AML or MDS
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study of How Well Macimorelin Works to Find Out if Children Have a Lack of Growth Hormone and How Safe it is
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: Macimorelin|DIAGNOSTIC_TEST: Arginine|DIAGNOSTIC_TEST: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Immersive Room for Visual Attention in Children With Autism Spectrum Disorders
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Autism
Interventions: BEHAVIORAL: Immersive room|BEHAVIORAL: stimuli in a paper format
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fluvastatin Sodium Extended Release Tablets 80 mg Once Daily in Chinese Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia
Status: COMPLETED
Conditions: Lipid Metabolism Disorders
Interventions: DRUG: Fluvastatin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Irritable Bowel Syndrome in Primary Care (MIBS Trial)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: mebeverine|DRUG: methylcellulose|DRUG: placebo|BEHAVIORAL: CBT website with support|BEHAVIORAL: No website|BEHAVIORAL: CBT website with minimal support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment by Surface Electromyography in Cerebral Palsy Footballers
Status: COMPLETED
Conditions: Assessment, Self|Cerebral Palsy|Technology Addiction
Interventions: DIAGNOSTIC_TEST: Adapted sport|DIAGNOSTIC_TEST: Adapted sport
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Intranasal Administration of Oxytocin in Adults With Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Oxytocin (OXT) continuous|DRUG: Placebo|DRUG: Placebo continuous|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polyglactin Sutures Versus Nylon Sutures for Suturing of Conjunctival Autograft in Pterygium Surgery: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Pterygium
Interventions: PROCEDURE: Polyglactin sutures for suturing of conjunctival autograft in pterygium surgery|PROCEDURE: Nylon sutures for suturing of conjunctival autograft in pterygium surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Induction and Maintenance Treatment of Advanced Non-squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Placebo|DRUG: Pemetrexed|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Profile of Remimazolam-alfentanil Combination for ERCP Sedation
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: remimazolam-alfentanil combination|DRUG: propofol-alfentanil combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A New Method for Delineation of Epileptic Brian Tissue During Epilepsy Surgery (The HFO Study)
Status: UNKNOWN
Conditions: Refractory Localization-related Epilepsy
Interventions: PROCEDURE: Tailoring of the resection based on biomarker in aEcoG during epilepsy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy Plus Surgery Versus Surgery First For Elderly Gastric Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Chemotherapy Effect|Elderly Patients|Surgery
Interventions: DRUG: Chemotherapy|PROCEDURE: Curative gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Adalimumab Plus Methotrexate (MTX) Versus Placebo Plus MTX on Cartilage in (RA) Patients
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics, Preliminary Pharmacokinetics and Tolerability of BIBB 1464 (Tablet) in Hyperlipemic Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBB 1464 MS low dose|DRUG: Placebo|DRUG: Pravastatin|DRUG: BIBB 1464 MS medium dose|DRUG: BIBB 1464 MS high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Anyu Peibo With Placebo in Treatment of MDD in China
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DRUG: Anyu Peibo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Initial Efficacy Study of the Vortx Rx for Treatment of Benign Prostatic Hyperplasia (US)
Status: TERMINATED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DEVICE: Vortx Rx - Histotripsy BPH Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability of LPRI-CF113 as an Oral Contraceptive in Females
Status: ACTIVE_NOT_RECRUITING
Conditions: Contraception|Change in Bone Mineral Density
Interventions: DRUG: Drospirenone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Web-Based Tool to Improve Breast Cancer Survivorship
Status: COMPLETED
Conditions: Breast Cancer|Hormone Dependent Neoplasms|Adherence to Hormone Therapy
Interventions: BEHAVIORAL: "OncoTool" Intervention (MBSR + HT education)|BEHAVIORAL: "Oncotool" Control (health +HT education)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Efficacy and the Safety of Dexmedetomidine Sedation on the Pediatric Intensive Unit(PICU) Patients.
Status: UNKNOWN
Conditions: Failed Conscious Sedation During Procedure
Interventions: DRUG: Midazolam|DRUG: Dexmedetomidine|DRUG: Dexmedetomidine|DRUG: Dexmedetomidine|DRUG: Fentanyl|OTHER: assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Combined Study in Pediatric Cancer Patients for Dose Ranging and Efficacy/Safety of Plerixafor Plus Standard Regimens for Mobilization Versus Standard Regimens Alone
Status: COMPLETED
Conditions: Ewing's Sarcoma/Soft Tissue Sarcoma|Neuroblastoma|Brain Tumors
Interventions: DRUG: plerixafor|DRUG: plerixafor|DRUG: plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regular Consumption of Leafy Vegetable Sauces and Micro-nutrient Status of Young Children in Burkina Faso
Status: WITHDRAWN
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Leafy vegetable-fish sauce|DIETARY_SUPPLEMENT: Leafy vegetable-fish/liver sauce|DIETARY_SUPPLEMENT: Misola
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Evaluation of a Nasal Mask for the Treatment of Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Obstructive Sleep Apnea
Interventions: DEVICE: Trial Nasal mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registry of Malignant Arrhythmias and Sudden Cardiac Death - Influence of Diagnostics and Interventions
Status: UNKNOWN
Conditions: Ventricular Tachycardia|Ventricular Fibrillation|Sudden Cardiac Death|Coronary Angiography|Electrophysiologic Testing (EP)|Catheter Ablation|Percutaneous Coronary Intervention (PCI)|Internal Cardioverter Defibrillator (ICD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Trial of Maternal Progesterone Therapy
Status: COMPLETED
Conditions: Congenital Heart Disease|Periventricular Leucomalacia|Brain Development|Cardiac Surgery|Neurodevelopmental Disability|Fetal Neuroprotection
Interventions: DRUG: Progesterone|DRUG: Vaginal lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INTREPID - IRay Plus Anti-VEGF Treatment For Patients With Wet AMD
Status: COMPLETED
Conditions: AMD|Wet AMD|Age-Related Macular Degeneration|Wet Age-Related Macular Degeneration|Macular Degeneration|Eye Diseases|Retinal Diseases
Interventions: DEVICE: IRay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Recto-Intercostal Fascial Plane Block in Epigastric Hernia Repair
Status: RECRUITING
Conditions: Recto-intercostal Fascial Plane Block|Epigastric Hernia|Analgesia
Interventions: PROCEDURE: recto-intercostal fascial plane block|DRUG: bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus
Status: RECRUITING
Conditions: Intracardiac Thrombus|STEMI|Heart Failure
Interventions: DRUG: Vitamin K antagonist|DRUG: Direct oral anticoagulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Evaluating Photobiomodulation Therapy for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DEVICE: Retilux|DEVICE: Sham Light Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Split-belt Treadmill|DEVICE: Transcutaneous Electrical Nerve Stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safe Stop Ipilimumab-nivolumab (IPI-NIVO) Trial
Status: RECRUITING
Conditions: Melanoma Stage IV|Melanoma Stage III|Immunotherapy|Toxicity, Drug
Interventions: DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Non-randomized, Non-comparative, Phase II Study of Safety and Immunogenicity of Combination of AZD1222 and rAd26-S for COVID-19 Prevention
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: AZD1222|BIOLOGICAL: rAd26-S
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Rimonabant as an Aid to Maintenance of Smoking Cessation
Status: COMPLETED
Conditions: Maintenance of Smoking Cessation
Interventions: DRUG: rimonabant (SR141716)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Relaxation Techniques on Pain, Fatigue and Kinesiophobia in Multiple Sclerosis Patients: A Three Arms Randomized Trial
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting|Pain, Chronic|Fatigue Syndrome, Chronic|Kinesiophobia
Interventions: BEHAVIORAL: PMR: Progressive Muscle Relaxation|BEHAVIORAL: BRT:Benson Relaxation Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE