pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: 24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Travoprost/timolol fixed combination, travoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Niraparib Combined With Anlotinib in Homologous Recombination Repair (HRR) Gene-mutated Advanced Solid Tumors
Status: UNKNOWN
Conditions: HER2-negative Breast Cancer|Gastric Adenocarcinoma|Cholangiocarcinoma|Pancreatic Cancer
Interventions: DRUG: Niraparib|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bleeding Pattern Difference Between Levonorgestrel Intrauterine System (LNG-IUS) and Copper Intrauterine Devices (IUDs) Immediately Inserted After Abortion
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Levonorgestrel IUS (Mirena, BAY86-5028)|DEVICE: Copper-IUD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ENGAGE4HEALTH: A Combination Intervention Strategy for Linkage and Retention in Mozambique
Status: COMPLETED
Conditions: HIV
Interventions: OTHER: Point of care CD4+ after HIV diagnosis|OTHER: Accelerated ART initiation|BEHAVIORAL: SMS appointment reminders|OTHER: Non-cash Financial Incentives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Immunogenicity of a Booster Dose of -H5N1 Influenza Vaccine
Status: COMPLETED
Conditions: Avian Influenza
Interventions: BIOLOGICAL: H5N1 influenza vaccine|BIOLOGICAL: H5N1 influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: DRUG: placebo administration|DRUG: EMLA|DRUG: propofol|DRUG: fentanyl citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity
Status: COMPLETED
Conditions: Spasticity|Stroke
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Psychology for Acute Coronary Syndrome Patients
Status: COMPLETED
Conditions: ACS - Acute Coronary Syndrome
Interventions: BEHAVIORAL: Positive Psychology + Motivational Interviewing|BEHAVIORAL: Motivational Interviewing Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mirtazapine and Methamphetamine Drug-drug Interaction Study
Status: RECRUITING
Conditions: Methamphetamine Use Disorder|Drug Interaction|Cardiovascular Abnormalities
Interventions: DRUG: Mirtazapine|DRUG: Methamphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prelabor Visual Biofeedback by a Self-operated Ultrasound Device
Status: RECRUITING
Conditions: Obstetric Labor Complications|Obstetric Trauma
Interventions: DEVICE: Visual Biofeedback using self operated home ultrasound device|DEVICE: Visual Biofeedback using ultrasound at hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of IPX054 and Immediate-Release Carbidopa-Levodopa in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: IPX054 200 mg|DRUG: CD-LD IR|DRUG: IPX054 Placebo|DRUG: CD-LD IR Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Male Infertility Related With Post Infection Inflammatory Syndrome
Status: COMPLETED
Conditions: Male Infertility|Leukopenia|Postinfection Inflammation|Oxidative Stress
Interventions: DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation
Status: COMPLETED
Conditions: End Stage Renal Disease (ESRD)
Interventions: DRUG: Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Egg Shell Nanoparticles Combined With Titanium Dioxide Nanoparticles
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: DRUG: Egg Shell nanoparticles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Post-Market Clinical Follow-Up Study of GORE-TEX® Vascular Grafts and GORE® PROPATEN® Vascular Graft in Peripheral Artery Disease, Aortic Aneurysms, and Dialysis Access
Status: COMPLETED
Conditions: PAD - Peripheral Arterial Disease|AAA - Abdominal Aortic Aneurysm|End-Stage Renal Disease
Interventions: DEVICE: GORE® PROPATEN® Vascular Graft|DEVICE: GORE-TEX® Vascular Grafts
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Restoration of Thumb Strength and Function in Basal Joint Arthritis: A Comparative Effectiveness Trial (RESTART)
Status: RECRUITING
Conditions: Osteoarthritis Thumb
Interventions: PROCEDURE: Trapeziectomy with ligament reconstruction (I; LRTI)|PROCEDURE: Trapeziectomy with suture suspensionplasty (II; SS)|PROCEDURE: Arthroscopic Trapeziectomy (III; AT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intelligent Follow-up of Neonatal Jaundice Based on Early Indicators and Internet Communications
Status: NOT_YET_RECRUITING
Conditions: Hyperbilirubinemia, Neonatal
Interventions: DIAGNOSTIC_TEST: end tidal carbon monoxide corrected for ambient carbon monoxide （ETCOc）|OTHER: Internet Plus technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function
Status: COMPLETED
Conditions: Physiological Effect of TCC on Glucose Metabolism
Interventions: BEHAVIORAL: Classical Yang's TCC exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Vasopressin on Kidney and Cardiac Function in Septic Shock
Status: RECRUITING
Conditions: Kidney Injury, Acute|Cardiac Function Failed
Interventions: DRUG: Vasopressor test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CBT Through Internet and Smartphones for Adults With ADHD - a Randomized Controlled Trial
Status: COMPLETED
Conditions: ADHD
Interventions: BEHAVIORAL: iCBT for Adults with ADHD|BEHAVIORAL: Internet stress-reduction|OTHER: Treatment as usual (TAU)/waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AK112 Neoadjuvant/Adjuvant Treatment for Resectable NSCLC
Status: NOT_YET_RECRUITING
Conditions: Resectable Non-small Cell Lung Cancer
Interventions: DRUG: AK112|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy of Microwave Ablation and Cellular Immunotherapy for Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: adoptive immunotherapy|PROCEDURE: MWA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Success After Laparoscopic vs Abdominal Hysterectomy
Status: COMPLETED
Conditions: Metrorrhagia|Menorrhagia|Leiomyoma|Adenomyosis|Pelvic Pain|Endometriosis|Pelvic Inflammatory Disease
Interventions: PROCEDURE: Laparoscopic hysterectomy|PROCEDURE: Abdominal hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: COMPARISON OF A NEW FORMULATION OF GOSERELIN (Pepti 3.6 mg) to Zoladex® 3.6 mg
Status: COMPLETED
Conditions: Dysfunctional Uterine Bleeding
Interventions: DRUG: Pepti 3.6 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery
Status: RECRUITING
Conditions: Cryotherapy Effect|Compression|Postoperative Pain Management
Interventions: DEVICE: Game Ready Cryotherapy with Compression Group|OTHER: Control Cryotherapy Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Genetic Polymorphisms of UGT on the PKs of Indapamide in Egyptians
Status: UNKNOWN
Conditions: Pharmacogenomics
Interventions: DRUG: Indapamide 1.5 MG SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of AAI101 Safety, Tolerability & PK in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AAI101 i.v.|DRUG: Saline 0.9% infusion|DRUG: Piperacillin i.v.|DRUG: Cefepime i.v.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Action of Epigenetic Modifiers in Cystic Fibrosis Treatment
Status: COMPLETED
Conditions: Cystic Fibrosis|Healthy Subjects
Interventions: OTHER: Tests in vitro after sampling nasal cells of CF patients or controls
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ginsenoside-Rd for Acute Ischemic Stroke
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: ginsenoside-Rd 10 mg|DRUG: placebo|DRUG: ginsenoside-Rd 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
Status: COMPLETED
Conditions: Glucocorticoid Effect
Interventions: DRUG: Metyrapone 250 mg Oral Tablets|DRUG: Placebo 250 mg Tablets|DRUG: Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s|DRUG: Placebo (0,9% NaCl solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Supplementing Intracytoplasmic Sperm Injection Handling Medium With Chaetoglobosin A ( ICSI-CA)
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Medium Supplemented with Chaetoglobosin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A First-in-Human Study of CDK-002 (exoSTING) in Subjects With Advanced/Metastatic, Recurrent, Injectable Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: CDK-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Immediate Implants With or Without a Volume-stable Collagen Matrix
Status: RECRUITING
Conditions: Edentulous Alveolar Ridge
Interventions: DEVICE: Volume-stable collagen matrix Geistlich Fibro-Gide®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Assessment of the iZephyr Hood for NIV in COVID-19 Patients
Status: NOT_YET_RECRUITING
Conditions: Aerosol Disease|Covid19|Noninvasive Ventilation
Interventions: DEVICE: iZephyr hood
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy
Status: COMPLETED
Conditions: Gastrointestinal Disease
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy and Safety of the HAV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis
Status: RECRUITING
Conditions: End Stage Renal Disease (ESRD)
Interventions: BIOLOGICAL: HAV|OTHER: AVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Patients With Carpal Tunnel Syndrome, Median Nerve Conduction is Evaluated After Nerve Mobilizations
Status: NOT_YET_RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Manual mobilizations of the median nerve|OTHER: Wrist movements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Training and Intermittent Hypoxia: Additive Health Effects?
Status: COMPLETED
Conditions: Pre-Hypertension
Interventions: PROCEDURE: RMT|PROCEDURE: RMT + IH|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fermented Rice Flour for the Treatment of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DIETARY_SUPPLEMENT: Rice Flour|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tele-reha Versus Paper-based Aftercare Programme Following Inpatient Rehabilitation
Status: RECRUITING
Conditions: Neurologic Disorder
Interventions: DEVICE: Tele-Reha provided with EvoPads|OTHER: Paper-based exercises with option to do tele-reha afterwards|OTHER: Only paper-based exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Killer Cell (CYNK-001) Infusions in Adults With Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma|Neoplasm, Plasma Cell|Neoplasms by Histologic Type|Neoplasms|Hemostatic Disorder|Vascular Diseases|Cardiovascular Diseases|Paraproteinemias|Blood Protein Disorders|Hematologic Diseases|Hemorrhagic Disorders|Lymphoproliferative Disorders|Immunoproliferative Disorders|Immune System Diseases|Antineoplastic Agents|Analgesics, Non-Narcotic|Analgesics|Sensory System Agents|Peripheral Nervous System Agents|Physiological Effects of Drugs
Interventions: BIOLOGICAL: CYNK-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of Different Methods of HPV DNA Testing for Cervical Cancer Screening in Primary Care Settings
Status: NOT_YET_RECRUITING
Conditions: Uterine Cervical Neoplasms
Interventions: DIAGNOSTIC_TEST: Self-sampled HPV DNA testing|DIAGNOSTIC_TEST: Clinician-sampled HPV DNA test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tripletrumab Combined With Oxaliplatin and Teggio (SOX) in First-line Treatment of Gastric and Gastroesophageal Junction Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Toripalimab combined with oxaliplatin and Tegafur,Gimeracil and Oteracil Porassium Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis
Status: COMPLETED
Conditions: Acute Pancreatitis
Interventions: PROCEDURE: surgical intervention after percutaneous catheter drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of SCT1000 in Healthy Women Aged 18 to 45 Years
Status: UNKNOWN
Conditions: Interventional|Prevention|Randomized
Interventions: BIOLOGICAL: SCT1000|BIOLOGICAL: Gardasil®9|BIOLOGICAL: Gardasil®|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Efficacy and Safety of PEG-rhG-CSF（Jinyouli®） in Reducing Neutropenia in Patients With Cervical Cancer
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: PEG-rhG-CSF|DRUG: rhG-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction|Functional Mitral Regurgitation
Interventions: DRUG: Sacubitril-valsartan|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplant (FMT) Plus Fidaxomicin for Severe or Fulminant Clostridium Difficile Infection
Status: TERMINATED
Conditions: Clostridium Difficile
Interventions: DRUG: Fidaxomicin 200 mg|BIOLOGICAL: fecal microbiota transplantation (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab With Taxane Therapy in Participants With Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Bevacizumab|DRUG: Paclitaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Phytoestrogens as Risk Factors for Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus|Rheumatoid Arthritis|Autoimmune Thrombocytopenia
Interventions: OTHER: blood sample|OTHER: urine sample|OTHER: food questionnaire|OTHER: hair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy Study of Multiple Micro Nutrients Supplementation
Status: UNKNOWN
Conditions: Anemia, Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: Multi-micronutrients|DIETARY_SUPPLEMENT: Maltodextrin and Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ADRENAL FUNCTION IN PATIENTS WITH ACUTE HEPATITIS
Status: COMPLETED
Conditions: Acute Hepatitis
Interventions: BIOLOGICAL: Measure OF SERUM TOTAL CORTISOL, SERUM FREE AND SALIVARY CORTISOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions
Status: COMPLETED
Conditions: Autofluorescence|Thyroidectomy|Hypoparathyroidism|Hypocalcemia
Interventions: DEVICE: Fluobeam LX, Fluoptics, Grenoble, France
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Compare "Balloon Occluded Thrombolysis" With "Conventional Catheter Directed Thrombolysis" in Thrombotically Occluded DIPSS Stent in Patients of Budd- Chiari Syndrome.
Status: COMPLETED
Conditions: Budd-Chiari Syndrome
Interventions: PROCEDURE: Novel|PROCEDURE: Conventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Healthy Eating, Activity and Reduction of Teen Stress
Status: COMPLETED
Conditions: Overweight and Obesity|Overweight Adolescents|Emotional Stress|Stress, Psychological|Eating Behavior
Interventions: BEHAVIORAL: Mindfulness-Based Weight Control (MBWC)|BEHAVIORAL: Standard Behavioral Weight Control (SBWC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Crizotinib Plus Pembrolizumab In Alk-Positive Advanced Non Small Cell Lung Cancer Patients
Status: TERMINATED
Conditions: ALK-positive Advanced NSCLC
Interventions: DRUG: Crizotinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed in Advanced Non-Small-Cell Lung Cancer: at Progression vs Maintenance Therapy After Induction Chemotherapy
Status: TERMINATED
Conditions: Carcinoma, Non-small-cell Lung
Interventions: DRUG: maintenance pemetrexed|DRUG: pemetrexed at progression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gram Type Infection-Specific Sepsis Identification Using Machine Learning
Status: WITHDRAWN
Conditions: Sepsis|Severe Sepsis|Septic Shock
Interventions: DIAGNOSTIC_TEST: InSight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Oral Contraceptive Study
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: YAZ (DRSP 3 mg/EE 0.02 mg, BAY86-5300)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Thalidomide to Chemotherapy Related Nausea and Vomiting in Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer Stage IV|Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Thalidomide|DRUG: Nab paclitaxel|DRUG: Gemcitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Phase I Trial of the Combination of Topotecan and PS-341, a Novel Proteasome Inhibitor, in Advanced Malignancies
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: topotecan hydrochloride|DRUG: bortezomib|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Dexmedetomidine on a Closed-Loop Anesthesia System
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: NaCl 9/00|DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Vaginal Ring for Delivery of TMC120 (Dapivirine)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: placebo vaginal ring|DRUG: TMC120 (dapivirine) vaginal ring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Study With an Enteral Formula With Symbiotic and DHA for Malnourished Children
Status: COMPLETED
Conditions: Cystic Fibrosis|Failure to Thrive|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Symbiotic Formula with DHA and antioxidants|DIETARY_SUPPLEMENT: Standard Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing MRI to CT on Pediatric Craniosynostosis.
Status: ENROLLING_BY_INVITATION
Conditions: Craniosynostosis
Interventions: DIAGNOSTIC_TEST: Zero Echo Time Magnetic Resonance Imaging (ZTE MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Intraoperative Pain and Quality of Surgical Block During Shoulder Surgery Assessed by NOL Index
Status: WITHDRAWN
Conditions: Shoulder Surgery|Regional Anesthesia Morbidity
Interventions: PROCEDURE: Suprascapular Nerve Block + Posterior Cord Block|PROCEDURE: Interscalene Brachial Plexus Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DLBS1033 for the Treatment of Acute Ischemic Stroke
Status: TERMINATED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Placebo|DRUG: DLBS1033
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Prostate Cancer Recurrent|Prostate Cancer Metastatic
Interventions: DRUG: 18F-DCFPyL|DIAGNOSTIC_TEST: PET/CT Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assess Safety & Efficacy of WC3055 in Men With Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: WC3055|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Chemotherapy and Subtenon Carboplatin, and Local Ophthalmic Therapy in Children With Intraocular Retinoblastoma
Status: COMPLETED
Conditions: Intraocular Retinoblastoma
Interventions: DRUG: liposomal vincristine sulfate|PROCEDURE: cryosurgery|PROCEDURE: laser surgery|DRUG: carboplatin|DRUG: etoposide|BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secondary Prophylaxis Gastric Variceal Bleed
Status: COMPLETED
Conditions: Cirrhosis
Interventions: PROCEDURE: Endoscopic Cyanoacrylate injection|DRUG: beta-blocker (propranolol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: How Does Dietary Carbohydrate Influence the Formation of an Atherogenic Lipoprotein Phenotype (ALP)?
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)
Interventions: OTHER: High sugar low starch diet|OTHER: Low sugar high starch diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Novel Intertransverse Plane Block: a Magnetic Resonance Imaging and Volunteer Study
Status: COMPLETED
Conditions: Intertransverse Process Block|Thoracic Nerve Block|Thoracic Paravertebral Block
Interventions: PROCEDURE: Intertransverse process block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Dexlansoprazole Modified Release Formulation to Treat Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Dexlansoprazole MR|DRUG: Dexlansoprazole MR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Human Chorionic Gonadotrophin as Luteal Phase Support in Frozen Embryo Transfer
Status: COMPLETED
Conditions: Subfertility
Interventions: DRUG: Human chorionic gonadotrophin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin α
Status: COMPLETED
Conditions: Ovulation Induction
Interventions: DRUG: Follitropin alpha (r-FSH)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevena Incision Management
Status: COMPLETED
Conditions: Cardiac Event|Arrest; Cardiac, Complicating Surgery|Coronary Bypass Graft Stenosis|Complication of Coronary Artery Bypass Graft
Interventions: DEVICE: Bilateral Internal Mammary Artery grafts|DEVICE: Prevena
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of CPX-351 Versus 7+3 in Patients 60-75 Years Old With Untreated High Risk (Secondary) Acute Myeloid Leukemia
Status: COMPLETED
Conditions: High Risk Acute Myeloid Leukemia
Interventions: DRUG: CPX-351|DRUG: 7+3 (cytarabine and daunorubicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vildagliptin 100 MG as Compared to Placebo as Add-on to Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin AM|DRUG: vildagliptin pm|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Comparative, Open-label Study of IV Monofer® Administered as Maintenance Therapy by Single or Repeated Bolus Injections in Comparison With IV Iron Sucrose in Subjects With CKD-5D
Status: COMPLETED
Conditions: Chronic Kidney Disease Stage 5 (Dialysis Dependent)
Interventions: DRUG: Monofer|DRUG: Iron sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Foretinib in Combination With Lapatinib in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Foretinib|DRUG: Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PARPi or Capecitabine Combined With PD-1 Inhibitors as Adjuvant Therapy in High-risk TNBC
Status: RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: As per the germline BRCA1/2 mutation status, the selection of either Fluzopalil or capecitabine in combination with Camrelizumab is made for adjuvant therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: International Trial of Efficacy of Cytoflavin in Head Trauma
Status: RECRUITING
Conditions: Head Trauma,Closed
Interventions: DRUG: Cytoflavin ((Inosine + Nicotinamide + Riboflavin + Succinic Acid)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Preoperative Dose of Gabapentin to Decreases Postoperative Pain in Ambulatory Anal Surgeries
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quantitative Fluorescence Endoscopy Using Durvalumab-680LT in Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Cancer
Interventions: DRUG: Fluorescence endoscopy using durvalumab-680LT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zoledronate in Treating Patients With Solid Tumors That Have Spread to the Bone
Status: COMPLETED
Conditions: Hypercalcemia of Malignancy|Lung Cancer|Metastatic Cancer|Pain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: zoledronic acid|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Serenity Therapy on Symptoms Distress, Coping Styles, and Emotional Regulation Among Geriatric Patients Undergoing Hemodialysis: a Randomized Controlled Trial
Status: RECRUITING
Conditions: Geriatric Patients
Interventions: BEHAVIORAL: Sernity intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relationship Between Tracheal and Left Pulmonary Artery Stenosis Index and Prognosis of PA Sling With Tracheal Stenosis
Status: COMPLETED
Conditions: Anomalies of Pulmonary Artery, Congenital
Interventions: PROCEDURE: tracheoplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prehabilitative Exercise Prior to Immobilization
Status: RECRUITING
Conditions: Sarcopenia|Skeletal Muscle Atrophy|Disuse Atrophy
Interventions: OTHER: Prehabilitative exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlation Endoscopic View of Airway Obstruction With RRa in OSA Patients Under DEX Monitored With SedLine EEG
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DEVICE: SedLine EEG|DEVICE: RRa monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Dimethyl Fumarate (DMF) in Relapsing Forms of Multiple Sclerosis (RMS) Participants in China
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Dimethyl fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Dose Escalation of 5-FU for Gastrointestinal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Esophagus Cancer|Appendix Cancer|Small Bowel Cancer|Ampullary Cancer
Interventions: OTHER: FOX dose-escalation algorithm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of New Eye Drop Formulations With Refresh Tears® in Patients With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: carboxymethylcellulose sodium based New Eye Drop Formulation 1|DRUG: carboxymethylcellulose sodium based New Eye Drop Formulation 2|DRUG: carboxymethylcellulose sodium based Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Olmesartan Comparison to Losartan in Hypertensive Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: olmesartan medoxomil|DRUG: Placebo|DRUG: losartan potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tadalafil for Duchenne Muscular Dystrophy
Status: TERMINATED
Conditions: Muscular Dystrophy, Duchenne
Interventions: DRUG: Tadalafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity
Status: COMPLETED
Conditions: Apnea
Interventions: DRUG: Prophylactic caffeine citrate|DRUG: Therapeutic caffeine citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Re-introduction of Pemetrexed and Cisplatin With Prolonged Angiogenic Blocking by Bevacizumab in Advanced Lung Cancer.
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Metastatic|Nonsquamous Nonsmall Cell Neoplasm of Lung
Interventions: DRUG: Cisplatin|DRUG: Bevacizumab|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bowel Prep vs Non-Bowel Prep for Laparoscopic Colorectal Surgery
Status: UNKNOWN
Conditions: Anastomotic Leak|Surgical Site Infection
Interventions: PROCEDURE: low residue diet/no standard bowel preparation|PROCEDURE: standard bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Microbial-derived TMAO Production From Carnitine Intake by Testing Fecal Bbu Gene
Status: RECRUITING
Conditions: Gut Dysbiosis for TMAO Production From L-carnitine Consumption
Interventions: DIETARY_SUPPLEMENT: L-carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlation of Arterial Blood Gas (ABG) and Venous Blood Gas (VBG) in the Undifferentiated Critically Ill Patient
Status: COMPLETED
Conditions: Patients Needing Blood Gases
Interventions: OTHER: Venous Blood Gas
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of ALPN-303 in Adult Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ALPN-303|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
Status: RECRUITING
Conditions: Depressive Disorder, Major|Anhedonia
Interventions: DRUG: Aticaprant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Scleroderma
Status: COMPLETED
Conditions: Digital Ulcers|Systemic Sclerosis
Interventions: DRUG: Bosentan 62.5 mg|DRUG: Bosentan 125 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N2007-01: Ultratrace™ Iobenguane I 131 in Patients With Relapsed/Refractory High-Risk Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: UltratraceTM Iobenguane I 131 Imaging|DRUG: UltratraceTM Iobenguane I 131 Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis
Status: COMPLETED
Conditions: Adhesive Capsulitis of the Shoulder
Interventions: PROCEDURE: Arthroscopy|PROCEDURE: Arthroscopic manipulation|OTHER: Home therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Omega-3 Supplementation on Serum Level and Gene Expression of IGF-1and IGFBP-3 in Men With CVD.
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Omega-3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis (MF)
Interventions: DRUG: Navitoclax|DRUG: Ruxolitinib|DRUG: Best Available Therapy (BAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Patients With Hereditary and Familial Colorectal Cancer by Using an Online Risk Tool
Status: COMPLETED
Conditions: Colorectal Cancer|Lynch Syndrome|Familial Colorectal Cancer
Interventions: OTHER: Offering an online risk assessment questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Positioning of the Tibial Cut in Unicompartmental Medial Knee Replacement by Using Patient Specific Cutting Guides.
Status: COMPLETED
Conditions: Knee Prosthesis
Interventions: PROCEDURE: Unicompartmental Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Distance Savvy: Testing Tele-Savvy, a Distance Dementia Family Caregiver Education Program
Status: COMPLETED
Conditions: Dementia|Alzheimer's Disease|Depression
Interventions: BEHAVIORAL: Tele-Savvy|BEHAVIORAL: Tele-Savvy|OTHER: iPad
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rheopheresis for Raynaud's and Digital Ulcers in Systemic Sclerosis
Status: UNKNOWN
Conditions: Systemic Sclerosis|Raynaud Phenomenon|Digital Ulcer|Scleroderma
Interventions: PROCEDURE: Rheopheresis treatment|DRUG: Intravenous Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Data Analysis of CKRT (Continuous Kidney Replacement Therapy) Treatments in Adult Mode With multiFiltratePRO
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury|Renal Failure
Interventions: OTHER: multiFiltratePRO with all CKRT treatment modes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preference, Satisfaction and Ease of Use of Genuair® (Pressair™) and Breezhaler® (Neohaler™) Inhalers in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: Genuair®|DEVICE: Breezhaler®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study of Lenalidomide and Ofatumumab for the Treatment of Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Lenalidomide|DRUG: ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: placebo|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Tolerability of PCI-24781 in Patients With Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Hodgkin Disease|Lymphoma, Non-Hodgkin
Interventions: DRUG: PCI-24781
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose of Vestibular Rehabilitation for Vestibular Hypofunction
Status: RECRUITING
Conditions: Vestibular Disorder
Interventions: DEVICE: Gaze stabilization Exercises using Virtual Reality Device|BEHAVIORAL: Gaze stabilization non-instrumented
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ondansetron on Spinal-induced Hypotension for Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Percutaneous Nephrolithotomy
Interventions: DRUG: Ondansetron group|DRUG: Saline group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Long Term Safety and Tolerability of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep
Status: COMPLETED
Conditions: Insomnia Disorder
Interventions: DRUG: Daridorexant 10 mg|DRUG: Daridorexant 25 mg|DRUG: Daridorexant 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics
Status: UNKNOWN
Conditions: Hypertension
Interventions: OTHER: Sevoflurane/oxygen/air/nitrous oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE