pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dog-rose, Cranberry Leaves, Cranberry Berries, Alfalfa, Fenugreek, Lemon Beebrush, Urtica and Sumac in Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: COMBINATION_PRODUCT: Capsules containing the combination products|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A PROMs Based Educational Tool (PROM-DA) for Patients Considering Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Total Knee Arthroplasty
Interventions: BEHAVIORAL: Baseline and Follow-up Surveys|OTHER: Patient Reported Outcome Measure informed Decision Aid|OTHER: Pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Green Coffee Extract Combined With Alpha-Lipoic Acid on Blood Glucose Homeostasis in Healthy Adults
Status: COMPLETED
Conditions: Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: GCE + Low ALA|DIETARY_SUPPLEMENT: GCE + High ALA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Personalized Reminder Information and Social Management System
Status: COMPLETED
Conditions: Social Isolation|Social Support (Formal and Informal)|Well-being/Quality of Life
Interventions: BEHAVIORAL: PRISM C: Computer Condition|BEHAVIORAL: PRISM B: Notebook Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Different Electrophysical Agents in Cervical Region Flexibility Training of Healthy Individuals
Status: COMPLETED
Conditions: Cervical Flexibility|Stretch|Physical Therapy|Electrotherapy
Interventions: PROCEDURE: Traction|PROCEDURE: Laser therapy|PROCEDURE: Hot pack|PROCEDURE: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bispecific Antibody Plus White Blood Cells in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: bispecific antibody MDX447|BIOLOGICAL: lymphokine-activated killer cells|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Randomized, Study to Evaluate the Iovera° Device in Treating Pain Associated With Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthritis of the Knee
Interventions: DEVICE: iovera°|DEVICE: iovera° Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rayner Toric IOL Rotational Stability
Status: UNKNOWN
Conditions: Cataract|Corneal Astigmatism
Interventions: PROCEDURE: Cataract surgery|DEVICE: Rayner T-flex Toric IOLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer)
Status: COMPLETED
Conditions: Iron-deficiency|Valvular Heart Disease
Interventions: PROCEDURE: myocardial biopsy|PROCEDURE: sternal bone marrow biopsy|BIOLOGICAL: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial
Status: RECRUITING
Conditions: Colonic Cancer|Rectal Cancer|Non Small Cell Lung Cancer
Interventions: DRUG: Sevoflurane|DRUG: Propofol|DRUG: Lidocaine IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Early Changes of Diabetes Parameters After Obesity Therapy
Status: UNKNOWN
Conditions: Bariatric Surgery Candidate
Interventions: OTHER: Laparoscopic sleeve gastrectomy|OTHER: Laparoscopic Roux-en-Y gastric bypass|OTHER: Caloric restriction diet|OTHER: easy digestible diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optetrak Posterior Stabilized Versus Optetrak Hi-Flex
Status: WITHDRAWN
Conditions: Arthropathy of Knee|Arthritis and/or Post-traumatic Degenerative Problems
Interventions: DEVICE: Optetrak PS|DEVICE: Optetrak Hi-Flex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Family Check-Up in Autism Services
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Behavior Problem|Emotional Problem
Interventions: BEHAVIORAL: Family Check-Up|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tele-Nursing on Parents of Circumcised Children
Status: COMPLETED
Conditions: Health Care Utilization|Nursing Caries
Interventions: OTHER: Tele nursing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes
Status: COMPLETED
Conditions: Murmur, Heart|Aortic Valve Stenosis|Tricuspid Regurgitation|Mitral Regurgitation|Innocent Murmurs|Heart Murmurs
Interventions: DEVICE: Use of Eko CORE and Eko DUO electronic stethoscopes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation
Status: COMPLETED
Conditions: Intubation; Difficult
Interventions: DRUG: dexmedetomidine group|DRUG: remifentanil group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Cholesterol Lowering Effect of an Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Patients With High Cholesterol and With High Cardiovascular Risk (0653A-809)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe (+) simvastatin|DRUG: Comparator : rosuvastatin calcium|DRUG: Comparator: Placebo (unspecified)|DRUG: Comparator: Placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Douching and Painting in Women Who Underwent Total Abdominal Hysterectomy
Status: COMPLETED
Conditions: Febrile Morbidity
Interventions: PROCEDURE: Vagina douching|PROCEDURE: Vagina painting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pandemic Influenza Plasmid DNA Vaccines (Needle-Free)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: VCL-IPM1|BIOLOGICAL: VCL-IPM1|BIOLOGICAL: VCL-IPT1|BIOLOGICAL: PBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fully Constrained Acetabular Liner vs. Dual Mobility Hip Joint in the Surgical Treatment of Metastatic Bone Disease of the Hip
Status: RECRUITING
Conditions: Metastatic Cancer to the Hip
Interventions: OTHER: Constrained Liner|OTHER: Dual Mobility
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition and Exercise Trial: Improving Diet and Physical Activity Patterns in Overweight Cancer Survivors
Status: COMPLETED
Conditions: Cancer Survivor|Overweight
Interventions: OTHER: Dietary Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Laboratory Biomarker Analysis|DIETARY_SUPPLEMENT: Nutritional Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of a Warming Mattress on Perioperative Hypothermia Following Cesarean Delivery
Status: TERMINATED
Conditions: Postoperative Hypothermia
Interventions: DEVICE: VitaHeat underbody heating mattress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Cancer Patients
Status: RECRUITING
Conditions: Endometrial Neoplasms|Atypical Endometrial Hyperplasia|Progesterone Resistance|Obesity
Interventions: DRUG: GnRH antagonist|DRUG: Letrozole 2.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutritional Counseling Based on Diet Quality on Metabolic Control in Patients With Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Nutritional Counseling|OTHER: Usual Diet Guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine, Levobupivacaine and Ropivacaine After Intrathecal and Extradural Injection in Labour
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: local anaesthetic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Treatment Combine With TXA for Elbow Stiffness
Status: UNKNOWN
Conditions: Tranexamic Acid|Elbow Stiffness
Interventions: DRUG: TXA|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ENABLE-1 (Engaging Toll-like Receptor Signalling for B-cell Lymphoma Chimeric Antigen Receptor Therapy)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphomas Non-Hodgkin's B-Cell|Diffuse Large B-cell Lymphoma (DLBCL)|Primary Mediastinal B-cell Lymphoma (PMBCL)|Transformed Follicular Lymphoma (TFL)|Follicular Lymphoma (FL)|Mantle Cell Lymphoma (MCL)
Interventions: BIOLOGICAL: WZTL002-1 (1928T2z CAR-T cells)|DRUG: Cyclophosphamide and Fludarabine lymphodepleting chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Saflutan® 15 microgram/ml Augentropfen im Einzeldosisbehältnis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Subjects With Previously Untreated Extensive-Stage Small-Cell Lung Cancer (SCLC) Treated With Platinum Plus Etoposide Chemotherapy With or Without Darbepoetin Alfa
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: placebo|DRUG: darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Interesterification of Commercially Used Fats on Postprandial Fat Metabolism
Status: COMPLETED
Conditions: Healthy Adults|Postmenopausal Women
Interventions: DIETARY_SUPPLEMENT: Interesterified blend of palm kernal and plam stearin|DIETARY_SUPPLEMENT: Un-interesterified blend of palm kernal and plam stearin|DIETARY_SUPPLEMENT: Rapeseed oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized Controlled Study on the Treatment of Cirrhosis Combined With Hypersplenism
Status: UNKNOWN
Conditions: Liver Cirrhosis|Esophageal and Gastric Varices|Hypersplenism
Interventions: PROCEDURE: Endoscopic therapy+ beta blockers|PROCEDURE: Endoscopic therapy+ PSE+beta blockers|PROCEDURE: Endoscopic therapy|PROCEDURE: Endoscopic therapy+ PSE|PROCEDURE: Endoscopic therapy+Somatostatin|PROCEDURE: Endoscopic therapy+PSE+Somatostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: pentostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Magnetic Resonance Imaging (fMRI) During Deep Brain Stimulation (DBS) to Treat Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Essential Tremor|Dystonia|Obsessive Compulsive Disorder
Interventions: PROCEDURE: Functional Magnetic Resonance Imaging (fMRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial to Evaluate Safety and Immunogenicity of INO-5150 Alone or With INO-9012 in Men With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: 2mg INO-5150 and electroporation device CELLECTRA®-5P|BIOLOGICAL: 8.5mg INO-5150 and electroporation device CELLECTRA®-5P|BIOLOGICAL: 2mg INO-5150 plus 1mg INO-9012 and electroporation device CELLECTRA®-5P|BIOLOGICAL: 8.5mg INO-5150 plus 1mg INO-9012 and electroporation device CELLECTRA®-5P|DEVICE: Electroporation using CELLECTRA®-5P
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Radiation Therapy in Treating Patients With Stage II or Stage III Cancer of the Larynx or Hypopharynx
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: docetaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery
Status: RECRUITING
Conditions: Acute Kidney Injury|Cardiac Surgery|Venous Congestion|Hemodynamic Stability
Interventions: OTHER: VeXUS score guided fluid management strategy|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vinorelbine Metronomic Chemotherapy Combined With Hypofractionated Radiotherapy, PD-1/PD-L1 Sequential GM-CSF and IL-2 for Treatment of Advanced Refractory Non-small Cell Lung Cancer and Breast Cancer(PRaG 6.0)
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma Breast
Interventions: DRUG: Vinorelbine|RADIATION: Radiotherapy|DRUG: PD-1/PD-L1 inhibitor|DRUG: GM-CSF|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH)
Status: COMPLETED
Conditions: Systemic Sclerosis|Pulmonary Hypertension
Interventions: DRUG: Ambrisentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adolescent Digital Mental Health-Kenya Effectiveness
Status: RECRUITING
Conditions: Mental Disorder in Adolescence
Interventions: BEHAVIORAL: mHealth Toolkit for Screening & Empowering Lives of Youth (mSELY-A) for Adolescents|BEHAVIORAL: mHealth Toolkit for Screening & Empowering Lives of Youth (mSELY-P) for Parents|OTHER: Control Tooklit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: The Eggs and actiVity in hEalth agiNg Pilot (EVEN-P) Trial in Older Persons
Status: WITHDRAWN
Conditions: Aging
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Exercise plus diet (egg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prophylaxis Prior to Cataract Surgery Conjunctival Flora and Optimal Ocular Sterilization Technique Prior to Cataract Surgery
Status: COMPLETED
Conditions: Endophthalmitis|Cataract Surgery|Prophylaxis
Interventions: DRUG: mupirocin ointment|OTHER: SOC sterilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Placebo-Controlled Study to Investigate the Onset of Action of Paroxetine in Premenstrual Dysphoria
Status: COMPLETED
Conditions: Premenstrual Dysphoric Disorder|Premenstrual Syndrome
Interventions: DRUG: paroxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Activity and Nutrition Trial in Lupus to Energize and Renew
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|Physical Activity|Sleep
Interventions: OTHER: Smartphone Application|OTHER: Fitbit Activity Monitor|OTHER: Coaching Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of YF476 and Rabeprazole on Gastric Function
Status: COMPLETED
Conditions: Hypergastrinaemia
Interventions: DRUG: YF476|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stereotactic Radiotherapy and Image-guided Intensity Modulated Radiotherapy for Spinal Metastatic Tumors
Status: UNKNOWN
Conditions: Radiotherapy|Spine Metastases|Radiosurgery
Interventions: RADIATION: Stereotactic radiotherapy|RADIATION: Conventionally-fractionated image- guided Intensity modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of MIS416 to Treat Secondary Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: BIOLOGICAL: MIS416|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ti-Mesh Frame Comparison for Alveolar Bone Augmentation
Status: ENROLLING_BY_INVITATION
Conditions: Tooth Loss
Interventions: PROCEDURE: CAD-CAM designed and preprinted Ti-Mesh frame|PROCEDURE: Conventional chairside fabrication of Ti-Mesh frame
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Increased Protein Intake on Colonic Metabolism
Status: COMPLETED
Conditions: Protein Fermentation|Toxicity in the Colon
Interventions: DIETARY_SUPPLEMENT: High protein intake|DIETARY_SUPPLEMENT: Low Protein intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Phase III Study to Evaluate the Efficacy and Safety of Xyzal® (Levocetirizine) vs Zyrtec® (Cetirizine) in Subjects With Dermatitis and Eczema
Status: COMPLETED
Conditions: Dermatitis|Eczema
Interventions: DRUG: Levocetirizine|DRUG: Cetirizine|DRUG: Placebo-Levocetirizine|DRUG: Placebo-Cetirizine|DRUG: Standard topical steroid (1% hydrocortisone) ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The CONQUEST-Study. Evaluation of Clinical Endpoints for Treatment-induced Changes in GERD-related Symptoms (BY1023/NL511)
Status: TERMINATED
Conditions: Gastroesophageal Reflux Disease|Non-erosive Reflux Disease
Interventions: DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Families With Substance Use and Psychosis: A Pilot Study
Status: COMPLETED
Conditions: Psychosis|Substance Use|Substance Use Disorders|Family|Tobacco Use|Nicotine Use Disorder|Cigarette Smoking|Cannabis|Marijuana|Alcohol Use Disorder|Alcohol|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Mental Disorder
Interventions: BEHAVIORAL: CRAFT-FT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia
Status: COMPLETED
Conditions: Ataxia, Cerebellar|Cerebellar Ataxia|Spinocerebellar Ataxias|Ataxia, Spinocerebellar|Spinocerebellar Ataxia Type 1|Spinocerebellar Ataxia Type 2|Spinocerebellar Ataxia 3|Spinocerebellar Degenerations|Friedreich Ataxia|Ataxia With Oculomotor Apraxia|Multiple System Atrophy
Interventions: DEVICE: Anodal cerebellar and cathodal spinal tDCS|DEVICE: Sham cerebellar and sham spinal tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: QuitBet Phase II: A Digital Social Game That Pays You to Stop Smoking
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: contingency management (deposit contract)|BEHAVIORAL: leaderboard and social feed|BEHAVIORAL: smoking cessation resource list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anticoagulation in Patients With Venous Thromboembolism and Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms|Embolism
Interventions: DRUG: Apixaban|DRUG: Rivaroxaban|DRUG: Edoxaban|DRUG: Dabigatran|DRUG: VKA|DRUG: LMWH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: S-1, Cisplatin, and Radiation Therapy in Treating Patients With Stage IIA, Stage III, or Stage IVA Esophageal Cancer That Can Be Removed by Surgery
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: cisplatin|DRUG: tegafur-gimeracil-oteracil potassium|OTHER: cytology specimen collection procedure|PROCEDURE: endoscopic biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Two Types of Fixed Lingual Retainers in Preventing Mandibular Incisor Relapse
Status: COMPLETED
Conditions: Relapse
Interventions: DEVICE: Orthodontic retainers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Safety and Performance of the EyenableTM Intraocular Lens for Cataract Treatment
Status: NOT_YET_RECRUITING
Conditions: Cataract
Interventions: DEVICE: EyenableTM PA60AS1 IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Dyskinesia Due to Cerebral Palsy
Status: RECRUITING
Conditions: Dyskinesia|Cerebral Palsy
Interventions: DRUG: Placebo|DRUG: Valbenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of the Combined Single Dose of Dactavira Plus Or Dactavira in Egyptian Adults With Chronic Genotype 4 HCV Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Dactavira Plus|DRUG: Sofosbuvir + Daclatasvir + Ribavirin|DRUG: Dactavira|DRUG: Sofosbuvir + Daclatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Certolizumab in Recurrent Implantation Failure (RIF)
Status: RECRUITING
Conditions: Recurrent Unexplained Implantation Failure
Interventions: DRUG: Certolizumab (CIMZIA® ; TNF-α antagonist)|DRUG: Placebo (NaCl 0.9 % solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation
Status: UNKNOWN
Conditions: Obesity
Interventions: PROCEDURE: Positive end-expiratory pressure (PEEP)|PROCEDURE: ZEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decreasing Stunting by Reducing Maternal Depression in Uganda: A Cluster Randomized Controlled Trial (CRCT) for Improved Nutrition Outcomes
Status: COMPLETED
Conditions: Depression, Postpartum|Malnutrition, Child
Interventions: OTHER: Care Groups|BEHAVIORAL: IPT-G
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Full-Thickness Placental Allograft in Lumbar Microdiscectomy
Status: TERMINATED
Conditions: Surgical Wound|Herniation
Interventions: OTHER: Other: Full-thickness placental allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Resilience Training for First Responders in the Opioid Epidemic
Status: COMPLETED
Conditions: Compassion Fatigue|Burnout|Stress|Mindfulness
Interventions: BEHAVIORAL: Mindfulness-Based Resilience Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physical Therapy Versus Internet-Based Exercise Training for Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: BEHAVIORAL: Internet Based Exercise Training|BEHAVIORAL: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of RO7062931in Healthy Volunteers and Subjects With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: RO7062931|DRUG: Placebo|DRUG: Immune Modulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Healthy vs Unhealthy Obesity: Mehanistic Insights and Effects of Time-Restricted Eating
Status: RECRUITING
Conditions: Metabolically Healthy Obesity|Intermittent Fasting
Interventions: BEHAVIORAL: Time-restricted eating
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Camrelizumab (Anti-PD-1 Antibody) in Recurrent HCC After Liver Transplantation
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Liver Transplantation
Interventions: DRUG: Camrelizumab treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of Near Infrared Transillumination in Combination With a Dye in the Cavitation Detection
Status: UNKNOWN
Conditions: Initial Proximal Caries
Interventions: DEVICE: Radiographic examination|DEVICE: Scanning with DIAGNOcam|DEVICE: Scan with DIAGNOcam and Indocyanine|DIAGNOSTIC_TEST: Visual-tactile exploration with separation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Apraxia of Speech: Comparison of EPG Treatment (Tx) and Sound Production Treatment (SPT)
Status: COMPLETED
Conditions: Apraxia of Speech|Aphasia, Acquired|Speech Disorders
Interventions: DEVICE: EPG Tx|BEHAVIORAL: SPT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholesterol Self-testing in Patients Post Acute Coronary Syndrome
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Prevention|LDL Hyperlipoproteinemia|Therapeutic Adherence
Interventions: OTHER: Cholesterol self-measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅱ
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DRUG: rt-PA|DRUG: rhTNK-tPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Lenrispodun|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diindolylmethane in Treating Patients With Abnormal Cervical Cells
Status: COMPLETED
Conditions: Cervical Cancer|Precancerous Condition
Interventions: DRUG: oral microencapsulated diindolylmethane|GENETIC: polymerase chain reaction|OTHER: cervical Papanicolaou test|OTHER: cytology specimen collection procedure|PROCEDURE: colposcopic biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Metabolic Syndrome Risk Factor in IGT: STOP-NIDDM Trial
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: acarbose|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM
Status: COMPLETED
Conditions: Tuberculosis Meningitis|HIV-1-infection
Interventions: DRUG: Linezolid|DRUG: High dose rifampicin|DRUG: Aspirin|DRUG: Standard of Care anti-tuberculous therapy|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Controlled Diet Combined With a Fermented Milk Product on Gas-related Symptoms
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders
Interventions: OTHER: Fermented milk product with probiotics (FMPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Folic Acid for Prevention of Contrast Induced Nephropathy
Status: UNKNOWN
Conditions: Kidney Diseases|Urologic Diseases
Interventions: DRUG: Folic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of DCC on Neonatal Jaundice and Blood Gas Analysis in Infants Born to GDM Mothers
Status: UNKNOWN
Conditions: Gestational Diabetes Mellitus|Neonatal Hyperbilirubinemia|Neonatal Asphyxia
Interventions: PROCEDURE: delayed cord clamping|PROCEDURE: early cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity
Status: COMPLETED
Conditions: Insulin Sensitivity/Resistance
Interventions: OTHER: 8 weeks of combined exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Uterine Repair Methods for Cesarean Delivery
Status: COMPLETED
Conditions: Complications; Cesarean Section
Interventions: PROCEDURE: Type A of uterine repair: In situ|PROCEDURE: Type B of uterine repair: Exteriorization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Protein and NAC Co-ingestion on Skeletal Muscle Recovery
Status: RECRUITING
Conditions: Aseptic Muscle Injury
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: NAC|DIETARY_SUPPLEMENT: NAC + Whey Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
Status: RECRUITING
Conditions: Erosive Esophagitis
Interventions: DRUG: Nexium 20mg|DRUG: Nexium 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of High Power Pain Threshold Ultrasound and Ischemic Compression Techniques for Treatment of Trigger Points
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial
Interventions: OTHER: high power pain threshold ultrasound which the dose was kept constant|OTHER: high power pain threshold ultrasound which the dose reduced to one half|OTHER: ischemic compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: NSAIDs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Low-frequency Magnetic Fields in the Hybrid Treatment of COVID-19 Patients
Status: RECRUITING
Conditions: COVID-19|COVID-19 Respiratory Infection|COVID-19 Pneumonia
Interventions: OTHER: magnetostimulation|OTHER: standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Evaluation of Blood Glucose Meter Systems in a Clinical Setting
Status: COMPLETED
Conditions: Diabetes
Interventions: DEVICE: Bayer G3 / Tatsu System|DEVICE: Accu-Chek® Aviva Nano Meter/Accu-Chek® Aviva Test Strips|DEVICE: Freestyle Lite® Meter and Test Strips with ZipwikTM tabs|DEVICE: OneTouch® Ultra®2 / OneTouch® Ultra® Blue Test Strips|DEVICE: One Touch® VerioTM Pro/One Touch® VerioTM Test Strips|DEVICE: Truetrack® Meter/Truetrack® Test Strips
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Modification of Diet in Renal Disease Study
Status: COMPLETED
Conditions: Chronic Renal Disease
Interventions: OTHER: Usual Protein Diet|OTHER: Low Protein Diet|OTHER: Very Low Protein Diet|DRUG: Medications needed to maintain usual blood pressure|DRUG: Medications needed to maintain low blood pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D in Pregnancy
Status: UNKNOWN
Conditions: Vitamin D Deficiency|Pre-Eclampsia|Fetal Growth Retardation|Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (90µg)|DIETARY_SUPPLEMENT: Vitamin D3 (10µg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Pretreatment to Reduce Pain and Discomfort During Fiberoptic Nasal Pharyngoscopy and Laryngoscopy
Status: COMPLETED
Conditions: Throat Disorder
Interventions: DRUG: Decongestant (oxymetazoline 0.05%)|DRUG: Anesthesia (Lidocaine 15%)|DRUG: Decongestants and Anesthesia (oxymetazoline and lidocaine)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Subcutaneous Testosterone to Intramuscular Testosterone in Gender Affirming Care of Transgender Male Adolescents
Status: COMPLETED
Conditions: Health Services for Transgender Persons|Transgender Persons
Interventions: DRUG: Testosterone injection|BEHAVIORAL: PedsQL questionnarie|OTHER: Masculinizing effects questionnaire|OTHER: Medication experience questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of the Safety and Immunogenicity of an Oral, Replicating Ad26 Vectored HIV-1 Vaccine
Status: COMPLETED
Conditions: HIV
Interventions: BIOLOGICAL: rcAd26.MOS1.HIV-Env 1x10^8 vp|BIOLOGICAL: rcAd26.MOS1.HIV-Env 1x10^9 vp|BIOLOGICAL: rcAd26.MOS1.HIV-Env 1x10^10 vp|BIOLOGICAL: rcAd26.MOS1.HIV-Env 1x10^11 vp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of MVA-NP+M1 in the Influenza H3N2 Human Challenge Model
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MVA-NP+M1|BIOLOGICAL: Saline|BIOLOGICAL: H3N2 (A/Belgium/2417/2015)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics and Safety of Sancuso and IV Granisetron in Pediatrics Aged 6 to 12 Years
Status: WITHDRAWN
Conditions: Chemotherapy Induced Nausea and Vomiting
Interventions: DRUG: Sancuso|DRUG: IV granisetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepatic Hilar Nerve Block Versus Sham in Pain Control During Liver Ablation and TACE Procedures
Status: RECRUITING
Conditions: Pain Control|Liver Cancer
Interventions: PROCEDURE: Hepatic Hilar Nerve Block Needle placement|DRUG: Injection of Ropivacaine in the hepatic hilum for the hepatic hilar nerve block|DRUG: Injection of normal saline in the hepatic hilum for the sham procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dobutamine for Management of Surgical Patients With Septic Shock
Status: RECRUITING
Conditions: Patients With Septic Shock|Surgical Patients|General Anesthesia
Interventions: DRUG: Dobutamine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)
Status: RECRUITING
Conditions: Chronic Graft-versus-Host-Disease|Allogeneic Hematopoietic Stem Cell Transplantation|Leukemia|Blood Cancer|Non-Malignant Hematologic and Lymphocytic Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Induction Chemotherapy Followed by Standard Therapy in Cervical Cancer With Aortic Lymph Node Spread
Status: RECRUITING
Conditions: Cervical Cancer TNM Staging Regional Lymph Nodes (N)
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Balance Study of Deferasirox, Deferoxamine and the Combination of Both
Status: UNKNOWN
Conditions: Thalassemia
Interventions: DRUG: Deferoxamine|DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of Melasma
Status: COMPLETED
Conditions: Melanosis
Interventions: DRUG: New trio de Kligman|DRUG: Trio Kligman
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: sIPOM vs pIPOM in Incisional Hernia Patients
Status: COMPLETED
Conditions: Incisional Hernia
Interventions: PROCEDURE: Intraperitoneal onlay mesh reinforcement with defect closure before placement of mesh (pIPOM)|PROCEDURE: Standard intraperitoneal onlay mesh repair (sIPOM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PhotobiomoduLation for pAtientS With Advanced hEart failuRe
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|Heart Failure, Systolic
Interventions: DEVICE: Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin Versus Ketamine in Treatment-Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: Psilocybin|DRUG: Ketamine Hydrochloride|DRUG: Midazolam Ph. Eur 9.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Back School and Supervised Walking in Sedentary Women With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: BEHAVIORAL: Back School Intervention|BEHAVIORAL: Supervised Walking Intervention|BEHAVIORAL: Back School and Walking|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A French Observational Study of Indocyanine Green for Patients With Breast Cancer Having a Sentinel Lymph Node Biopsy.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Sentinel lymph node identification|DRUG: indocyanine green|DRUG: methylene blue|DRUG: Technetium (99mTc)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PR104 and G-CSF in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: PR104|OTHER: F-18-fluoromisonidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mellowing Mind: Comparing Two Technology Based Mindfulness Interventions for Stress Impacted by COVID-19 in Underserved Communities
Status: ACTIVE_NOT_RECRUITING
Conditions: Worry|Stress
Interventions: BEHAVIORAL: Teleconference Mindfulness Intervention|BEHAVIORAL: Smartphone App Mindfulness Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Continous Adjuvant Lidocaine on General Anaesthesia on Tumor Craniotomy Surgery
Status: COMPLETED
Conditions: Surgery|Anesthesia; Functional|Haemodynamic Instability
Interventions: DRUG: NaCl 0.9%|DRUG: Adjuvant lidocaine continous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Exchanging a Double Lumen Tube to a Proseal Laryngeal Mask or a Single Lumen Tube After a Thoracic Surgery
Status: COMPLETED
Conditions: Cough|Laryngospasm|Apnea|Desaturation|Voice Hoarseness
Interventions: DEVICE: LMA Proseal|DEVICE: Tracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postoperative Pain Management After Minimally Invasive Esophagectomy
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: OTHER: continuous epidural infusion|OTHER: combined paravertebral infusion and single shot of TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis
Status: COMPLETED
Conditions: Lupus Nephritis|Systemic Lupus Erythematosus
Interventions: DRUG: KZR-616
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lenalidomide, Doxorubicin and Dexamethasone (RAD) in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Relapse|Refractory Multiple Myeloma
Interventions: DRUG: Revlimid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Intake of Corbella Extra Virgin Olive Oil on the Microbiota-gut-brain Axis in Healthy Adults (HEVOOC)
Status: COMPLETED
Conditions: Healthy Nutrition
Interventions: OTHER: EXTRA VIRGIN OLIVE OIL|OTHER: OLIVE OIL LOW POLYPHENOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION