pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease With Constipation
Status: RECRUITING
Conditions: Parkinson's Disease|Fecal Microbiota Transplantation
Interventions: PROCEDURE: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duration of Anti-PD-1 Therapy in Metastatic Melanoma
Status: RECRUITING
Conditions: Unresectable/Metastatic Melanoma
Interventions: DRUG: Intermittent PD-1 inhibitor therapy|DRUG: Continuous PD-1 inhibitor therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model
Status: UNKNOWN
Conditions: Ischemia-Reperfusion Injury|Myocardial Infarction
Interventions: DRUG: Epoetin alpha|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS)
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: MRI|OTHER: Clinical Exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dovitinib in Treating Patients With Recurrent or Progressive Glioblastoma
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor
Interventions: DRUG: dovitinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Brief Alcohol Intervention for Non Dependant Alcohol-misusing Patients Undergoing a Scheduled Surgery
Status: TERMINATED
Conditions: Alcohol Abuse|Alcohol Problem|AOD Misuse
Interventions: OTHER: Brief Alcohol intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or Secondary Myelodysplasia Previously Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant
Status: TERMINATED
Conditions: Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: donor lymphocytes|BIOLOGICAL: filgrastim|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: busulfan|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: mycophenolate mofetil|DRUG: tacrolimus|OTHER: reduced-intensity transplant conditioning procedure|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Altered Tumor Oxygenation by Metformin, a Potential Step in Overcoming Radiotherapy Resistance in LACC
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Metformin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Use of a Behavioral Health App Versus Care as Usual for 16-22 Year Olds With Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: dCBI|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity to Modify Sequelae and Quality of Life in Childhood Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: BEHAVIORAL: Physical Therapy|BEHAVIORAL: Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Packing Following Endoscopic Endonasal Pituitary Resection
Status: RECRUITING
Conditions: Pituitary Tumor
Interventions: PROCEDURE: No nasal packing.|PROCEDURE: Nasal Packing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potential Therapeutic Role of Effervescent Calcium-Magnesium Citrate in Chronic Kidney Disease Stage V
Status: RECRUITING
Conditions: CKD Stage 5
Interventions: DRUG: EffCaMgCit|OTHER: CaAcS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation of Ankle Muscles in Persons With SCI
Status: TERMINATED
Conditions: Spinal Cord Injuries|Spastic Gait|Foot Drop
Interventions: OTHER: Whole Body Vibration (WBV)|OTHER: Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparative Effectiveness Trial for Diagnosis of Necrotizing Enterocolitis
Status: RECRUITING
Conditions: Necrotizing Enterocolitis
Interventions: DIAGNOSTIC_TEST: Bowel Ultrasound|DIAGNOSTIC_TEST: Abdominal radiograph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hysteroscopic Versus Laparoscopic Tubal Occlusion in Cases of Hydrosalpinx and Planning for IVF
Status: COMPLETED
Conditions: Tubal Obstruction
Interventions: PROCEDURE: Laparoscopic and hysteroscopic tubal occlusion for hydrosalpinx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Evaluating the Safety and Effectiveness of The Tixel Fractional System in The Treatment of Periorbital Wrinkles
Status: COMPLETED
Conditions: Wrinkle|Periorbital|Tixel 2|Fractional|Resurfacing
Interventions: DEVICE: Tixel 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess SLN124 in Patients With Polycythemia Vera
Status: RECRUITING
Conditions: Polycythemia Vera
Interventions: DRUG: SLN124|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Placebo-controlled Phase 1 Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-1014-6470 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACT-1014-6470|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Efficacy of 10-day or 14-day Course of Bismuth-containing Quadruple Therapy:A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: 10-day Tegoprazan bismuth-containing quadruple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Fasting for the Treatment of Type 2 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Intermittent energy restriction (IER)|BEHAVIORAL: Time Restricted Eating (TRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal
Status: COMPLETED
Conditions: Anal Cancer|Rectal Cancer
Interventions: DRUG: Axalimogene filolisbac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma Patients
Status: RECRUITING
Conditions: Melanoma|Melanoma Stage III|Melanoma Stage IV|Unresectable Melanoma
Interventions: DIAGNOSTIC_TEST: 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sertaconazole 2% Cream to Improve Symptoms Associated With Atopic Dermatitis
Status: COMPLETED
Conditions: Skin Alterations Associated With Atopic Dermatitis
Interventions: DRUG: Sertaconazole 2% cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate Efficacy And Safety Of An Additional Dose Of Celecoxib (YM177) In Patients With Post-Tooth Extraction Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Celecoxib|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide
Status: RECRUITING
Conditions: Functional Constipation
Interventions: DRUG: Linaclotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wound Healing Following Tooth Extraction and Ridge Preservation Using DFDBA Alone in Particulate Fiber Form and in Combination With Xenograft
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Extraction|Wound Heal
Interventions: DEVICE: Vallos|DEVICE: Vallomix|DEVICE: Vallos-F|DEVICE: Vallomix-F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Eriobotyra Japonica Lindley Extract on Improvement of Cognitive Function
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Eriobotyra Japonica Lindley Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency
Status: COMPLETED
Conditions: Addison's Disease
Interventions: DRUG: dehydroepiandrosterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Paclitaxel Plus Epirubicin Versus Vinorelbine Plus Epirubicin in Breast Cancer With TEKT4 Variations
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Vinorelbine plus Epirubicin|DRUG: Paclitaxel plus Epirubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib Plus I-125 Seed Brachytherapy vs. Lenvatinib for TACE-refractory HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: PROCEDURE: Lenvatinib Plus I-125 Seed Brachytherapy|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Trial to Assess the Safety, Tolerability, and Pharmacokinetics of GS 9411 in Subjects With Cystic Fibrosis (CF)
Status: WITHDRAWN
Conditions: Cystic Fibrosis|Mucociliary Clearance
Interventions: DRUG: GS-9411|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Pharmacogenomic Variants for Cardiology Therapeutics
Status: COMPLETED
Conditions: Thrombosis|Stent Thrombosis|Bleeding|Myocardial Infarction|Ischemic Stroke
Interventions: DIAGNOSTIC_TEST: Cipherome Lighthouse Pilot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exparel Injection Effect on Postoperative Opioid Usage
Status: ENROLLING_BY_INVITATION
Conditions: Thyroid|Parathyroid Adenoma
Interventions: DRUG: Lidocaine Epinephrine|DRUG: Bupivacaine Hydrochloride-EPINEPHrine|DRUG: Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pectointercostal+ESP Block on Postoperatif Analgesia in Open Heart Surgery
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Pectointercostal and ESP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EMDR in Psychiatric Inpatients With Severe Mental Disorder
Status: COMPLETED
Conditions: Severe Mental Disorder|Psychological Trauma
Interventions: BEHAVIORAL: Eye Movement Desensitization and Reprocessing (EMDR) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-427 When Given to Patients With Advanced and Refractory Solid Tumors or Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: CUDC-427
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low-Fat Food on Pexidartinib Pharmacokinetics in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Treatment A - 400 mg Fasting|DRUG: Treatment B - 400 mg Fed|DRUG: Treatment C - 200 mg Fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thermosoftening of Double-lumen Tube for Airway Exchanger Catheter
Status: UNKNOWN
Conditions: Intubation Complication|Hoarseness|Sore Throat
Interventions: PROCEDURE: non-thermosoftening|PROCEDURE: thermosoftening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination of Netupitant and Palonosetron (Akynzeo®) in the Treatment of Refractory CINV
Status: TERMINATED
Conditions: Chemotherapy Induced Nausea Vomiting
Interventions: DRUG: Netupitant and Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preoperative and Postoperative Sublingual Misoprostol for Prevention of Postpartum Blood Loss in Cesarean Section
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Prevent Exposure to Tobacco Smoke at Home [Gesunde Atemluft zu Hause]
Status: UNKNOWN
Conditions: Smoking|Passive Smoking|Exposure to Environmental Smoke
Interventions: BEHAVIORAL: bio-chemical feedback and expert system intervention ETS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Procalcitonin-guided Algorithm on Early Discontinuation of Antibiotic Therapy
Status: RECRUITING
Conditions: Bacterial Infections
Interventions: PROCEDURE: Measurement of the PCT plasma levels|PROCEDURE: Usual practice based on guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate the Potential Efficacy and Safety of Human Umbilical Cord Blood and Plasma
Status: UNKNOWN
Conditions: Aging
Interventions: OTHER: Fresh cord blood(experimental group A)|OTHER: Frozen cord blood(experimental group B)|OTHER: Frozen plasma(experimental group C)|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Platelet Rich Plasma on Healing of Operated Pilonidal Sinus by Open Method
Status: COMPLETED
Conditions: Pilonidal Disease of Natal Cleft
Interventions: BIOLOGICAL: Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Falls Among Older Fallers to Test the Effect of LIVE-LiFE, a Home-Based, Tailored Fall Prevention Program
Status: COMPLETED
Conditions: Fall Prevention
Interventions: OTHER: LIVE-LiFE to Prevent Falls Among Older Fallers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation
Status: TERMINATED
Conditions: Dystonia|Parkinson Disease|Essential Tremor
Interventions: BEHAVIORAL: Music Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A PK Study GL2702 GLARS-NF1 and Omix Ocas® in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GL2702 GLARS-NF1|DRUG: Omix Ocas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extension Study of CTAP101-CL-3001 or CTAP101-CL-3002
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hyperparathyroidism, Secondary|Vitamin D Deficiency
Interventions: DRUG: CTAP101 Capsules|DRUG: Calcitriol|DRUG: Doxercalciferol|DRUG: Paricalcitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Electro-acupuncture Versus Manual Acupuncture on Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis Of Knee
Interventions: DEVICE: Electro-acupuncture|DEVICE: Manual acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II
Status: COMPLETED
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: Symetis ACURATE neo™ transfemoral TAVI system|DEVICE: Medtronic CoreValve Evolut R TAVI System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance
Status: COMPLETED
Conditions: Stroke, Acute, Stroke Ischemic
Interventions: DRUG: Tenecteplase|DRUG: Intravenous tissue plasminogen activator (tPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone furoate (FF)|DRUG: vilanterol (VI)|DRUG: umeclidinium bromide (UMEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation for TMD
Status: RECRUITING
Conditions: Temporomandibular Disorder|TMJ Disc Displacement With Reduction|TMJ Disc Displacement Without Reduction|Masticatory Myofascial Pain|TMJ Arthralgia|TMD Headache
Interventions: OTHER: Telerehabilitation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metformin ER 750 mg Tablets, Fed
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glucophage® XR 750 mg Tablets|DRUG: Metformin ER 750 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Beta-Amyloid Imaging With [18F]NAV4694 PET in Predicting Progression to AD in Subjects MCI
Status: TERMINATED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: [18F]NAV4694
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg and Salmeterol 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 100/50 mcg Inhalation Powder/GSK in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Propionate 100 mcg and Salmeterol 50 mcg inhalation Powder/Respirent Pharmaceuticals|DRUG: ADVAIR DISKUS® 100/50 mcg inhalation powder pre-dispensed/GSK|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Scheduled Intranasal Ketamine
Status: WITHDRAWN
Conditions: Pain|Trauma
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib Combined With PD-1 mAb and mFOLFIRINOX for Metastatic Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreas Cancer
Interventions: DRUG: Bortezomib Injection|DRUG: Sintilimab|DRUG: mFOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy for Colorectal Cancers Using CEA-Pulsed Dendritic Cells and Subsequent IL-2 Treatment
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: CEA pulsed dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Edentulous Maxilla Opposed by 2-implant Mandibular Overdenture?
Status: ENROLLING_BY_INVITATION
Conditions: Prosthesis Durability
Interventions: DEVICE: Maxillary implant overdenture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PAIR Study-PAP And IOP Relationship: Study 1
Status: TERMINATED
Conditions: Obstructive Sleep Apnoea|Primary Open Angle Glaucoma
Interventions: OTHER: Application of continuous positive airway pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antigen-specific T Cell Therapy for Patients With Relapsed Refractory Multiple Myeloma
Status: SUSPENDED
Conditions: Relapsed Refractory Multiple Myeloma
Interventions: BIOLOGICAL: NEXI-002 T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study
Status: NOT_YET_RECRUITING
Conditions: Periodontal Diseases|Furcation Defects
Interventions: PROCEDURE: root resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motor Learning Approaches From Working on a Vertical Surface in Hemiplegic Children's Upper Limb Motor Skills
Status: COMPLETED
Conditions: Hemiplegia|Spastic
Interventions: OTHER: motor learning and occupational therapy|OTHER: Motor Learning Approaches From Working on a Vertical Surface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: RFA+Highly-purified CTL vs. RFA Alone for Recurrent HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: RFA|PROCEDURE: RFA+highly-purified CTL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Maternal Mental Health & SUD Screening and Treatment
Status: ENROLLING_BY_INVITATION
Conditions: Mental Health Issue|Substance Use Disorders|Postpartum Depression|Postpartum Anxiety
Interventions: BEHAVIORAL: Listening to Women & Pregnant and Postpartum People
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparison of Caudal Block and Sacral Erector Spinae Block for Postoperative Analgesia
Status: COMPLETED
Conditions: Postoperative Pain|Children, Only
Interventions: PROCEDURE: Regional anesthesia intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Magnetic Resonance Imaging for Better Selection of Pancreatic Cancer Patients for Surgery: A Randomized Clinical Trial
Status: UNKNOWN
Conditions: Pancreas Cancer
Interventions: OTHER: MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Practical Telemedicine to Improve Control and Engagement for Veterans With Clinic-Refractory Diabetes Mellitus
Status: COMPLETED
Conditions: Telemedicine
Interventions: OTHER: PRACTICE-DM|OTHER: Standard VA Home Telehealth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Outcome of Esmolol Potassium Cardioplegia Compared to Potassium Cardioplegia in Patients With Solitary Valvular Disease; Randomized Controlled Study
Status: UNKNOWN
Conditions: Cardioplegia Solution Adverse Reaction
Interventions: DRUG: Esmolol|DRUG: Potassium Cardioplegic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: RCT Comparing the DEXA Results of the HA-Omnifit Versus the Symax Uncemented Hip Stem
Status: COMPLETED
Conditions: Patients With Osteoarthritis of the Hip Joint Elligable for a Uncemented Hipprosthesis
Interventions: PROCEDURE: uncemented total hip arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: OTHER: Self Epley Manoeuvre|OTHER: Brandt-Daroff Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dental Implants Rehabilitation in Patients With Vitamin D3 Imbalance
Status: COMPLETED
Conditions: Tooth Loss|Vitamin D3 Deficiency|Osteomalacia
Interventions: PROCEDURE: Dental implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Autologous RPE Versus Translocation of Autologous RPE and Choroid in AMD
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: PROCEDURE: Transplantation of autologous RPE|PROCEDURE: Translocation of autologous RPE and Choroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Recombinant M2e Influenza-A Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza A Vaccine: ACAM FLU-A|BIOLOGICAL: Influenza A Vaccine: ACAM FLU-A|BIOLOGICAL: Influenza A Vaccine: ACAM FLU-A|BIOLOGICAL: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: This is a Phase II, Open-label, Multicentre Study of Zanubrutinib-containing Regimens in Patients With Newly Diagnosed Mantle Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, Mantle-Cell|Lymphoma, Non-Hodgkin
Interventions: DRUG: Zanubrutinib,Obinutuzumab|DRUG: Zanubrutinib and R-BAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Knockout Engineered T Cells for Muscle-invasive Bladder Cancer
Status: WITHDRAWN
Conditions: Invasive Bladder Cancer Stage IV
Interventions: BIOLOGICAL: PD-1 Knockout T Cells|DRUG: Cyclophosphamide|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BAY43-9006 - Phase II Study in Non-Small Cell Lung Carcinoma (NSCLC)
Status: COMPLETED
Conditions: Cancer|Carcinoma, Non-Small Cell Lung
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Whitening Dentifrices on Tooth Color and Sensitivity
Status: COMPLETED
Conditions: Dentin Hypersensitivity
Interventions: OTHER: whitening dentifrices|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE)
Status: COMPLETED
Conditions: Frontotemporal Dementia|Dementia|Multi-Infarct Dementia|Vascular Dementia|Mixed Dementia|Alzheimer Disease|Lewy Body Disease|Pick Disease|Neurocognitive Disorders
Interventions: BEHAVIORAL: COPE online training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Preemptive Intravenous Ibuprofen on Postoperative Edema and Trismus in the Third Molar Teeth
Status: UNKNOWN
Conditions: Trismus|Edema
Interventions: DRUG: arveles|DRUG: intrafen|OTHER: placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Patient-individualized Peptide Vaccination Based on Tumor-specific Mutations in Children and Young Adults With Primary/Relapsed ALL
Status: COMPLETED
Conditions: Primary/Relapsed Acute Lymphoblastic Leukemia (ALL) of Childhood, Adolescents and Young Adults
Interventions: BIOLOGICAL: Individual peptide vaccination with adjuvant GM-CSF and Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FDG-Positron Emission Tomography (PET)/CT In the Evaluation of Persistent Febrile Neutropenia in Cancer Patients
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: [18F]fluoro-2-deoxy-D-glucose (FDG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of ANAVEX3-71 in Adults With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: ANAVEX3-71 oral capsules|DRUG: Placebo oral capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Youth FORWARD Phase 1 YRI and EPP Study
Status: COMPLETED
Conditions: Mental Health Disorder|Mental Health Impairment|Psychosocial Impairment|Emotional Dysfunction
Interventions: BEHAVIORAL: YRI|BEHAVIORAL: EPP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Carrier Outlook Toward Reproduction Survey
Status: COMPLETED
Conditions: Hypohidrotic Ectodermal Dysplasia|X-Linked Hypohidrotic Ectodermal Dysplasia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Detection of Proximal Coronary Artery Disease in the Work-up for Transcatheter Aortic Valve Implantation Using CTA (From the DEPICT CTA Database)
Status: COMPLETED
Conditions: Computed Tomography Angiography|Coronary Artery Disease|Coronary Angriography|Aortic Valve Disease
Interventions: DIAGNOSTIC_TEST: Computed tomography angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploring the Effect of Video Interventions on Intentions for Continued COVID-19 Vaccination
Status: COMPLETED
Conditions: Vaccine Refusal|COVID-19
Interventions: BEHAVIORAL: Informational Video|BEHAVIORAL: Altruistic Video|BEHAVIORAL: Individualistic Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Pediatric Anxiety Disorders by Predicting Treatment Response Through Biocellular Markers and Sleep
Status: TERMINATED
Conditions: Generalized Anxiety Disorder|Separation Anxiety Disorder|Social Phobia
Interventions: DRUG: Sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Probiotic and Prebiotic Combinations on Premature Infants
Status: COMPLETED
Conditions: Premature Infants|Stool Bacterial Composition|Growth
Interventions: DIETARY_SUPPLEMENT: ProBioPlus|DIETARY_SUPPLEMENT: Culturelle|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: DAREON™-7: A Study to Test How Well Different Doses of BI 764532 in Addition to Chemotherapy Are Tolerated by People With Advanced Neuroendocrine Cancers
Status: RECRUITING
Conditions: Neuroendocrine Neoplasms
Interventions: DRUG: BI 764532|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Two Different Radiosurgery
Status: COMPLETED
Conditions: Metastases to Brain
Interventions: RADIATION: Radiosurgery with Gamma Knife Perfexion|RADIATION: Linac-based Radiosurgery with EDGE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Maraviroc (MCV) on the Immunological Recovery of HIV-1 Discordant Patients With CD4 Lymphocyte Counts Below 200 Cells/mm3
Status: UNKNOWN
Conditions: HIV-1 Infection
Interventions: DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
Status: COMPLETED
Conditions: Anti-Psychotic|Management of Manifestations of Psychotic Disorders|Treatment of Schizophrenia|Control Nausea and Vomiting|Relief of Restlessness and Apprehension Before Surgery|Acute Intermittent Porphyria|Adjunct in the Treatment of Tetanus|Control Manifestations of the Manic Type of Mani-depressive Illness|Relief of Intractable Hiccups
Interventions: DRUG: Chlorpromazine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Different Timing for Early Laparoscopic Cholecystectomy in Acute Calcular Cholecystitis
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: from the onset of symptoms within the first 3 days|PROCEDURE: : from the onset of symptoms within the 4-7 days|PROCEDURE: from the onset of symptoms beyond 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Iron Overload Requiring Chelation Therapy
Status: WITHDRAWN
Conditions: Transfusional Iron Overload|Iron Overload|Iron Chelation|Beta-thalassemia|Transfusional Hemosiderosis|Iron Metabolism Disorders|Metabolic Diseases
Interventions: DRUG: SPD602|DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Job Interview Training in Severe Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Depressive Disorder
Interventions: BEHAVIORAL: Virtual Reality Job Interview Training|OTHER: Supported Employment (Services as Usual)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Individualized, Precise and Standardized Cervical Open-door Surgery for Cervical Spinal Stenosis
Status: RECRUITING
Conditions: Cervical Spinal Stenosis|Cervical Spinal Cord Injury|Individuation|Standardization
Interventions: PROCEDURE: Centerpiece titanium plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adipose Tissue Inflammation in HFpEF
Status: UNKNOWN
Conditions: Heart Failure With Preserved Ejection Fraction|Obesity
Interventions: DIAGNOSTIC_TEST: Adipose and myocardial tissue sampling|DIAGNOSTIC_TEST: Cardiac magnetic resonance imaging|DIAGNOSTIC_TEST: Cardiopulmonary exercise testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: International Collaboration of Comprehensive Physiologic Assessment
Status: COMPLETED
Conditions: Stable Angina|Unstable Angina|Non-ST Elevation Myocardial Infarction|ST-segment Elevation Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lifestyle Intervention for Young Adults With Serious Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Major Depressive Disorder|Overweight|Obesity
Interventions: BEHAVIORAL: PeerFIT|BEHAVIORAL: BEAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diffusion Tensor (DTI) for the Assessement of Therapeutic Evolution of Patients With Acute Lumbar Radiculalgia
Status: RECRUITING
Conditions: Lumbar Radiculopathy|Magnetic Resonance Imaging|Diffusion Tensor Imaging
Interventions: OTHER: DTI sequence acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sentinel Lymph Node After Neoadjuvant Chemotherapy in Breast Carcinoma
Status: UNKNOWN
Conditions: Invasive Breast Cancer|Axillary Metastases
Interventions: PROCEDURE: Tagged axillary metastatic node
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Modified and Immediate Release Anatabine Citrate Formulations
Status: COMPLETED
Conditions: Pharmacokinetics of Anatabine
Interventions: DRUG: Modified Release Formulation x (MRx)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Delipid Extracorporeal Lipoprotein Filter From Plasma (DELP) for Acute Hemorrhagic Stroke
Status: SUSPENDED
Conditions: Hemorrhagic Stroke
Interventions: DEVICE: DELP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association Between SNP of SP-D and Susceptibility and Prognosis of Infectious Keratitis
Status: COMPLETED
Conditions: Infectious Keratitis
Interventions: DRUG: Treatment of bacterial keratitis|DRUG: Treatment of fungal keratitis|DRUG: Treatment of viral keratitis|DIAGNOSTIC_TEST: corneal scraping|OTHER: Sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF Veterans
Status: COMPLETED
Conditions: Lower Back Pain
Interventions: DRUG: Pregnenolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Anti-HIV Monoclonal Antibody KD-247
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: KD-247|DRUG: Physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ibrutinib With Rituximab in People With Untreated Marginal Zone Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Marginal Zone Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Rituximab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Positron Emission Tomography in the Evaluation of Response to Sorafenib in Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: Positron emission tomography with fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety and Effectiveness of PCV Chemotherapy in Patients With Recurrent High-grade Glioma With IDH1/2 Mutation
Status: UNKNOWN
Conditions: Recurrent High-grade Glioma
Interventions: DRUG: Lomustine/Vincristine/Procarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of JMT101 Combined Wth Docetaxel / HB1801 in Patients With Squamous Cell Non-Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Squamous Cell Non-small Cell Lung Cancer
Interventions: DRUG: JMT101|DRUG: docetaxel|DRUG: HB1801
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Trial of the Immunogenicity and Safety of the Gam-COVID-Vac Vaccine Against COVID-19 in the UAE
Status: UNKNOWN
Conditions: Covid19|SARS-CoV Infection
Interventions: BIOLOGICAL: Gam-COVID-Vac|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Indoor Air Quality and Respiratory Symptoms in Former Smokers
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: HEPA portable air filter|OTHER: Sham Control/Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Changes in Perception and Cognition During a Meditation Retreat
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BEHAVIORAL: 10 days intensive meditation retreat|BEHAVIORAL: Waiting for a 10 days intensive meditation retreat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topiramate in Adolescents With Severe Obesity
Status: COMPLETED
Conditions: Obesity, Morbid|Obesity|Weight Loss
Interventions: DRUG: Topiramate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-detectable Endotracheal Tube: a Feasibility Study
Status: RECRUITING
Conditions: Cardiac Catheterization|Endotracheal Tube
Interventions: DEVICE: Ultrasound detectable cuffed endotracheal tube (USD-ETT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study Evaluating AL-3778 in Combination With Peginterferon Alpha-2a in Chronic Hepatitis B Subjects
Status: WITHDRAWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: AL-3778|DRUG: Peginterferon Alfa-2A|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Tumor|Cervical Cancer
Interventions: DRUG: 18F-FTX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC