pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Yoga-Based Exercise Program For Temporomandibular Disorders
Status: COMPLETED
Conditions: Temporomandibular Disorders|Myofascial Pain Dysfunction Syndrome|Temporomandibular Joint Pain|Range of Motion|Yoga|Quality of Life
Interventions: OTHER: Yoga Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled ETD001 in Healthy Subjects
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: ETD001 single dose|DRUG: Placebo single dose|DRUG: ETD001 multiple twice daily doses|DRUG: Placebo multiple twice daily doses|DRUG: ETD001 multiple once daily doses|DRUG: Placebo multiple once daily doses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Milk Product Substitution for Patients Suffering From Xerostomia Caused by Medication
Status: WITHDRAWN
Conditions: Xerostomia
Interventions: OTHER: LactoXeros|DEVICE: Aequasyal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Quantification Near Stented SFA Lesions Using Ultrasound Velocimetry
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DIAGNOSTIC_TEST: High-frame-rate contrast-enhanced ultrasound measurements (echoPIV)|DIAGNOSTIC_TEST: Computed tomography angiography (CTA) scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Life With Covid Since 2020: a Randomized Control Trial of a Real-time Data Collection Smartphone-based App Assessing and Treating the Covid-19 Psychological Impacts
Status: WITHDRAWN
Conditions: PTSD
Interventions: OTHER: Real-time assessment using the VieCovid2020 smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Apexification Treatment With MTA(Mineral Trioxide Aggregate) and Ca(OH)2
Status: COMPLETED
Conditions: Immature Teeth
Interventions: OTHER: Mineral trioxide aggregate|OTHER: Calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Ciclesonide Nasal Spray in Patients With Perennial Allergic Rhinitis During One Year Treatment (BY9010/M1-404)
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis|Allergic Rhinitis|Hay Fever
Interventions: DRUG: Ciclesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Omalizumab (Anti-IgE) on the Late-phase Response to Nasal Allergen Challenge
Status: COMPLETED
Conditions: Cat Allergy
Interventions: DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches
Status: WITHDRAWN
Conditions: Postdural Puncture Headache
Interventions: DRUG: 2% lidocaine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Doses of Intranasal Dexmedetomidine as Premedication in Children
Status: COMPLETED
Conditions: Patient Between 1-8 Years Old Undergoing Elective Surgery at Queen Mary Hospital
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Machine Learning Sepsis Alert Notification Using Clinical Data
Status: UNKNOWN
Conditions: Sepsis|Severe Sepsis|Septic Shock
Interventions: OTHER: HindSight|OTHER: InSight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Distress in the Pediatric Oncology Setting: Intervention Versus Natural Adaptation
Status: COMPLETED
Conditions: Pediatric Cancer
Interventions: OTHER: My Special Aflac Duck (MSAD)|BEHAVIORAL: Standard of care control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Myocardial Contrast Echocardiography for the Assessment of the Infarct Related Artery & Risk Area in Patients w/ NSTEMI.
Status: UNKNOWN
Conditions: STEMI
Interventions: PROCEDURE: Echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Aromatherapy on Nausea Levels
Status: COMPLETED
Conditions: Nausea, Postoperative
Interventions: OTHER: QUEASEEase aromatherapy quick tab|OTHER: Placebo product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety and Efficacy of Donafinib Combined With Anti-PD-1 Antibody as Adjuvant Therapy for HCC Patients
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Donafenib and anti-PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
Status: RECRUITING
Conditions: Melanoma|Non-Small-Cell Lung Cancer|Thyroid Cancer|Glioma
Interventions: DRUG: PF-07799933|DRUG: binimetinib|BIOLOGICAL: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nexavar-Tarceva Combination Therapy for First Line Treatment of Patients Diagnosed With Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Erlotinib (Tarceva)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of the Antidepressant Duloxetine in Plasma to Improve the Knowledge of the Analgesic Action of Antidepressants on Chronic Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exploratory Study of Efficacy on Selected Natural Extracts Reducing Post Prandial Blood Glucose Response
Status: COMPLETED
Conditions: Blood Glucose
Interventions: OTHER: Mulberry fruit|OTHER: Mulberry leaf|OTHER: White bean|OTHER: Apple|OTHER: Elderberry|OTHER: Turmeric|OTHER: Rice porridge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interaction Between Fosamprenavir/Ritonavir and a Single-dose Olanzapine (FORZA)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: fosamprenavir/ritonavir|DRUG: olanzapine|DRUG: olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating IL28B Polymorphism in Patients With HBeAg-Negative Chronic Hepatitis B Treated With Pegasys (Peginterferon Alfa-2a) in Study ML18253
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: OTHER: Interleukin 28B testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Heidelberg In Vivo Confocal Microscopy to Evaluate the Ocular Surface Disorders of Healthy and Diseased Individuals
Status: UNKNOWN
Conditions: Healthy Individuals|Diabetes|Hypertension|Fabry Disease|Metabolic Disease|Alzheimer Disease|Dementia|Limbal Insufficiency|Phlyctenulosis|Ocular Rosacea|Graft Versus Host Disease in Eye|Dry Eye Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SEP and the Impact of Price on Food Selection in a Simulated Food Delivery App
Status: NOT_YET_RECRUITING
Conditions: Food Selection|Healthy Eating|Eating Behavior
Interventions: BEHAVIORAL: Price reduction on healthier foods|BEHAVIORAL: Price increase to less healthy foods|BEHAVIORAL: Combination of price reduction on healthier foods and price increase on less healthy foods|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab
Status: UNKNOWN
Conditions: Mucinous Adenocarcinoma of the Colon|Mucinous Adenocarcinoma of the Rectum|Recurrent Colon Cancer|Recurrent Rectal Cancer|Signet Ring Adenocarcinoma of the Colon|Signet Ring Adenocarcinoma of the Rectum|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: BIOLOGICAL: panitumumab|DRUG: irinotecan hydrochloride|DRUG: fluorouracil|DRUG: leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Biodentine and Mineral Trioxide Aggregate in Sealing Root Perforations
Status: COMPLETED
Conditions: Root Perforation at the Bifurcation Area
Interventions: DRUG: Biodentine|DRUG: MTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors
Status: RECRUITING
Conditions: Atypical Teratoid/Rhabdoid Tumor|Epithelioid Sarcoma|Kidney Medullary Carcinoma|Malignant Solid Neoplasm|Poorly Differentiated Chordoma|Recurrent Atypical Teratoid/Rhabdoid Tumor|Recurrent Chordoma|Recurrent Epithelioid Sarcoma|Recurrent Kidney Medullary Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Rhabdoid Tumor|Refractory Atypical Teratoid/Rhabdoid Tumor|Refractory Chordoma|Refractory Epithelioid Sarcoma|Refractory Kidney Medullary Carcinoma|Refractory Malignant Solid Neoplasm|Refractory Rhabdoid Tumor|Rhabdoid Tumor
Interventions: BIOLOGICAL: Atezolizumab|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|OTHER: Fludeoxyglucose F-18|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Tiragolumab|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of NY-ESO-1 ISCOMATRIX® in Patients With High-risk, Resected Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: NY-ESO-1 ISCOMATRIX®|BIOLOGICAL: ISCOMATRIX® adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Study of Intra-Uterine Growth Restriction
Status: RECRUITING
Conditions: IUGR|Pregnancy
Interventions: RADIATION: Ultrasound|RADIATION: MRI|PROCEDURE: Blood collection|BEHAVIORAL: Neurological Function Assessment|PROCEDURE: Placental Analysis|PROCEDURE: Measurement of body fat|RADIATION: Pediatric heart ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Gabapentin on Postoperative Morphine Consumption After Sleeve Gastrectomy
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: DRUG: Gabapentin|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375
Status: TERMINATED
Conditions: Healthy Male Volunteers
Interventions: DRUG: BP1.5375 suspension|DRUG: Diphenhydramine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS-Related Primary Central Nervous System Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|HIV Infections
Interventions: DRUG: Filgrastim|DRUG: Vincristine sulfate|DRUG: Doxorubicin hydrochloride|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Telaprevir in Treatment-Naive Participants With Chronic Genotype 4 Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Telaprevir|DRUG: Pegylated-interferon-alfa-2a|DRUG: Placebo|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safe Use of Medication at Home by Caregivers. Experimental Study
Status: NOT_YET_RECRUITING
Conditions: Caregivers of Multi-pathological and Polypharmacy Adults
Interventions: BEHAVIORAL: Psychoeducational intervention for safe medication use at home + Medication dosing device|DEVICE: Medication dosing device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2
Status: RECRUITING
Conditions: Heart Failure, Systolic|Inflammation
Interventions: DRUG: Anakinra|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lutein on Learning and Memory in Chronically Stressed Subjects and in an Acute Stressful Situation (TSST - Trier Social Stress Test): A Randomized, Double-blind, Placebo-controlled Trial)
Status: COMPLETED
Conditions: Healthy But Chronically Stressed
Interventions: DIETARY_SUPPLEMENT: Nutritional beverage fortified with 6mg lutein/day|DIETARY_SUPPLEMENT: Nutritional beverage fortified with 12mg lutein/day|DIETARY_SUPPLEMENT: Nutritional beverage fortified with 12mg lutein/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RCT of CBT for Insomnia With PLWHA
Status: COMPLETED
Conditions: Insomnia|HIV|Aids
Interventions: BEHAVIORAL: CBT-I Treatment Condition|BEHAVIORAL: SH Comparison Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect Of a Goat Milk-Based Infant Formula On Gastrointestinal And Other Symptoms And Health-Related Quality Of Life.
Status: NOT_YET_RECRUITING
Conditions: Infant Nutrition Disorders|Gastrointestinal Diseases
Interventions: DIETARY_SUPPLEMENT: Goat milk-based infant formula|DIETARY_SUPPLEMENT: Cow milk-based infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Light Intensity in Home Workplaces on Remote Workers' Health
Status: WITHDRAWN
Conditions: Daytime Cognitive Performance|Sleep|Alertness
Interventions: OTHER: Bright Lighting|OTHER: Placebo Lighting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly
Status: RECRUITING
Conditions: Sarcopenia|Bladder Cancer
Interventions: DIAGNOSTIC_TEST: sarcopenia and mobility measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Stress
Interventions: BEHAVIORAL: Psychological background determinations|GENETIC: Genetic susceptibility determination|PROCEDURE: Cortisol release test|PROCEDURE: Saliva cortisol measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Absorption and Safety With Sustained Use of RELiZORB Evaluation (ASSURE) Study
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: RELiZORB (immobilized lipase) cartridge|OTHER: Impact Peptide 1.5
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Cisplatin Single Dose Versus Split Dose in the Treatment of Patients With Locally Advanced or Metastatic Breast Cancer After Failure of Anthracyclines and/or Taxanes
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: gemcitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics on the Periodontal Status of Orthodontic Patients
Status: RECRUITING
Conditions: Periodontal Health|Gingivitis
Interventions: DIETARY_SUPPLEMENT: Oral probiotics (L. reuteri)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: WS®1442 in Slightly Overweight Subjects
Status: COMPLETED
Conditions: Overweight
Interventions: DRUG: WS® 1442 900 mg/d|DRUG: WS® 1442 1800 mg/d|BEHAVIORAL: Nordic walking training 2 x 30 min/week|BEHAVIORAL: Nordic walking training 4x45 min/week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Surgical Treatment of Pelvic Joint Instability in Patients With Severe Pelvic Girdle Pain After Pregnancy and Trauma
Status: COMPLETED
Conditions: Pelvic Joint Instability|Pelvic Pain
Interventions: PROCEDURE: Arthrodesis to the sacroiliac joint and symphysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia
Status: COMPLETED
Conditions: Male Infertility, Azoospermia
Interventions: DRUG: 13-cis retinoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ARO-APOC3 in Adults With Mixed Dyslipidemia
Status: COMPLETED
Conditions: Mixed Dyslipidemia
Interventions: DRUG: ARO-APOC3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib and Nivolumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Classical Hodgkin Lymphoma
Interventions: DRUG: Ibrutinib|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Improved Outcomes Among Ambulatory Diabetes and/or Hypertensive Patients - an Intervention Study (CPCLINT)
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus|Hypertension
Interventions: BEHAVIORAL: Educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess the Safety, Tolerability and Efficacy of NVA237 Versus Placebo
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Glycopyrronium bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Colorectal Carcinoma|Advanced Digestive System Carcinoma|Advanced Gastric Carcinoma|Advanced Gastroesophageal Junction Adenocarcinoma|Clinical Stage III Gastric Cancer AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IV Gastric Cancer AJCC v8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Metastatic Colorectal Carcinoma|Metastatic Digestive System Carcinoma|Metastatic Gastric Carcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Stage III Colorectal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Diagnostic Imaging|DRUG: Elimusertib|DRUG: Fluorouracil|DRUG: Irinotecan Hydrochloride|DRUG: Leucovorin Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Misoprostol Versus Oxytocin Infusion On Reducing Blood Loss During Abdominal Myomectomy
Status: RECRUITING
Conditions: Myoma;Uterus
Interventions: DRUG: Misoprostol 200mcg Tab|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Curative Effect Between New Tension Band and Patellar Tension Reduction Band in the Treatment of Lower Pole Fractures of Patella
Status: COMPLETED
Conditions: Follow-up Time, Postoperative Knee Joint Score, Postoperative X-ray, Follow-up Postural Image Data
Interventions: PROCEDURE: New type of tension band or patellar tension reduction band for treatment of lower pole fracture of patella
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Two-week Study Assessing the Onset of Effect Questionnaire Administered Pre-dose Versus Post-dose in Adult Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Budesonide/formoterol pMDI|DRUG: Budesonide HFA pMDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) vs. Best Supportive Care in Participants With Previously Systemically Treated Advanced Hepatocellular Carcinoma (MK-3475-240/KEYNOTE-240)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Placebo|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immunogenicity of tOPV in 1 to 5 Years and at 6 Weeks of Age
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Oral Polio Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Uterocervical Angle: a Screening Tool That Estimates the Latent Phase Duration in Post Term Pregnancies
Status: COMPLETED
Conditions: Post Term Pregnancy
Interventions: OTHER: latent phase duration|OTHER: uterocervical angle (UCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Pilot Study Comparing the Effectiveness of Campus Intervention to Increase HPV Vaccine Rate Among College Aged Men
Status: TERMINATED
Conditions: Human Papilloma Virus, Male
Interventions: BEHAVIORAL: Message X Onsite/Offsite Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus
Status: RECRUITING
Conditions: Barrett Esophagus
Interventions: DEVICE: IVLCM tethered capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: ECMO ABI Detection With Hyperfine
Status: RECRUITING
Conditions: Acute Brain Injury|Extracorporeal Membrane Oxygenation Complication|Hypoxia-Ischemia, Brain|Stroke, Acute
Interventions: DEVICE: Hyperfine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Fluzoparib in Combination With mFOLFIRINOX in Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: Fluzoparib|DRUG: Fluzoparib placebo|DRUG: mFOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of XP23829 in Subjects With Moderate-to-Severe Chronic Plaque-Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: XP23829 400 mg QD|DRUG: XP 23829 800 mg QD|DRUG: XP23829 400 mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coupling Between Clotting Characteristics in Chronic Hemodialysis Patients and the Hemodialyzer Patency
Status: COMPLETED
Conditions: Bleeding|Coagulation
Interventions: OTHER: Amount of anticoagulant Clexane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VTEval Project - Prospective Cohort Studies to Evaluate and Improve Diagnostics, Management Strategies and Risk Stratification in VTE
Status: RECRUITING
Conditions: Venous Thromboembolism (VTE)|Deep Vein Thrombosis (DVT)|Pulmonary Embolism (PE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Escócia Association in the Treatment of Acute Pain
Status: WITHDRAWN
Conditions: Acute Pain
Interventions: DRUG: Escócia association|OTHER: Placebo Ketorolac|OTHER: Placebo Scopolamine|DRUG: Ketorolac Tromethamine|DRUG: Scopolamine|OTHER: Placebo Escócia association
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Delayed Tolerance Through Mixed Chimerism
Status: RECRUITING
Conditions: Kidney Failure|Kidney Transplant; Complications|Chimera
Interventions: OTHER: Bone Marrow Transplant|PROCEDURE: Peripheral Blood Stem Cell Collection|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Rituximab|DRUG: Siplizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers
Status: TERMINATED
Conditions: Breast Carcinoma|Healthy Subject|Malignant Soft Tissue Neoplasm|Sarcoma|Skin Carcinoma
Interventions: PROCEDURE: Photoacoustic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improvement of Memory in Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: transcranial alternating current stimulation (tACS)|DEVICE: high-density electroencephalography (hdEEG)|DIAGNOSTIC_TEST: Montreal Cognitive Assessment (MoCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 1
Status: NOT_YET_RECRUITING
Conditions: Healthy Aging|Health Care Utilization|Health-Related Behavior
Interventions: OTHER: Annual Wellness Visit|OTHER: Geriatric Resources and Assessment for the Care of Elders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dual Target CAR-T Cells in B-cell Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Dual-target CAR-T Cells|B ALL|Relapse|Refractory B Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Dual target CAR-T cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Silymarin Cream Versus Combined Silymarin Cream and Microneedling in Treatment of Melasma
Status: UNKNOWN
Conditions: Melasma
Interventions: COMBINATION_PRODUCT: Silymarin|PROCEDURE: Microneedling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 - Study of the Kinetics of the Immune Response During the Intensive Care Unit Stay in Adult Patients Infected With SARS-CoV-2: Multicentric Non Interventional Study
Status: UNKNOWN
Conditions: Intensive Care Unit|SARS-Cov-2
Interventions: BIOLOGICAL: Collection of blood samples in order to create a biocollection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Azithromycin Plus Hydroxychloroquine for COVID-19 Infection
Status: WITHDRAWN
Conditions: Respiratory Tract Infection Viral
Interventions: DRUG: Azithromycin plus hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GeoAsma: Pilot and Evaluation of a Clinical Decision Support System and a Mobile App for the Management of Asthma Patients.
Status: RECRUITING
Conditions: Asthma
Interventions: OTHER: Clinical Decission support system management & mobile App Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Endorectal Three-dimensional Ultrasound in the Diagnosis of Cryptogenic Fistulas of the Rectum.
Status: UNKNOWN
Conditions: Anal Fistula
Interventions: DIAGNOSTIC_TEST: The method of transrectal ultrasound in В-mode|DIAGNOSTIC_TEST: The method of transrectal ultrasound examination using three-dimensional image reconstruction.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Mechanical Ventilation on the Incidence of Pneumothorax After Subclavian Vein Catheterization
Status: COMPLETED
Conditions: Subclavian Vein Catheterization
Interventions: OTHER: Lungs were not mechanically ventilated during subclavian vein catheterization|OTHER: Lungs were mechanically ventilated during subclavian vein catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study in the Treatment of Children and Adolescents With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: duloxetine|DRUG: Placebo|DRUG: fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association Between tDCS and Lokomat Training in Patients With Incomplete Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Outpatient active group|DEVICE: Outpatient placebo group|DEVICE: Inpatient active group|DEVICE: Inpatient placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)
Status: ACTIVE_NOT_RECRUITING
Conditions: Grade 2 Glioma|Residual Glioma|Recurrent Glioma
Interventions: DRUG: Vorasidenib|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Uterine Cancer
Status: TERMINATED
Conditions: Stage IA Uterine Sarcoma|Stage IB Uterine Sarcoma|Stage IC Uterine Sarcoma|Stage IIA Uterine Sarcoma|Stage IIB Uterine Sarcoma|Stage IIIA Uterine Sarcoma|Stage IIIB Uterine Sarcoma|Stage IIIC Uterine Sarcoma|Stage IVA Uterine Sarcoma|Stage IVB Uterine Sarcoma|Uterine Carcinosarcoma
Interventions: DRUG: paclitaxel|DRUG: carboplatin|RADIATION: external beam radiation therapy|RADIATION: brachytherapy|RADIATION: intensity-modulated radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Golden Halo, Static Magnetic and Electric Field Device, in Recurrent Glioblastoma
Status: WITHDRAWN
Conditions: Glioblastoma|Recurrent Glioblastoma
Interventions: DEVICE: Static Magnetic and Electric (sBE) device|DRUG: Lomustine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BEZ235 as Monotherapy in Patients With Transitional Cell Carcinoma After Failure of Platinum Based Chemotherapy
Status: TERMINATED
Conditions: Carcinoma Transitional Cell
Interventions: DRUG: BEZ235
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Palbociclib (PD-0332991) as a Potential Targeted Treatment in Cancers With CCND1, 2, 3 Amplification (MATCH-Subprotocol Z1B)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm
Interventions: DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PSMA PET/CT Guided Intensification of Therapy in Patients at Risk of Advanced Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PSMA PET/CT guided intensification of therapy|OTHER: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Ketogenic Diet Intervention During Radiotherapy on Body Composition
Status: COMPLETED
Conditions: Neoplasms
Interventions: DIETARY_SUPPLEMENT: MyAmino|DIETARY_SUPPLEMENT: betaquik|RADIATION: Radio(chemo)therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Microbiome-based Prognostical Biomarkers in Patients With Morbid Obesity and Bariatric Surgery
Status: COMPLETED
Conditions: Obesity, Morbid|Bariatric Surgery Candidate|NAFLD|Microbiome
Interventions: PROCEDURE: Bariatric surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapeutic Effects of Insoles on Patients With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: OTHER: customized insoles|OTHER: ready made insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ChAMP (Chondral Lesions And Meniscus Procedures) Trial
Status: COMPLETED
Conditions: Meniscal Tear|Chondromalacia
Interventions: PROCEDURE: Arthroscopic debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovation for Small-scale Experiments: ReceptIVFity Test
Status: RECRUITING
Conditions: Pregnancy Related|Infertility, Female|Subfertility, Female
Interventions: OTHER: ReceptIVFity test (vaginal microbiome swab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of SHR-1703 in Asthma
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: SHR-1703|DRUG: placebo|DRUG: SHR-1703|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Geriatric Intervention in Frail Patients With Gastric, Biliary, and Pancreatic Cancer Receiving Palliative Chemotherapy
Status: RECRUITING
Conditions: GI Cancer
Interventions: BEHAVIORAL: Frailty intervention measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Persistent Postsurgical Pain After Thoracotomy
Status: COMPLETED
Conditions: Persistent Pain|Postoperative Hyperalgesia
Interventions: DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fixed-dose vs. Phenotype-based PrAsugrel Dose to MATCH Therapeutic Zone in Asians With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Platelet Thrombus|Bleeding
Interventions: DRUG: Prasugrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites
Status: COMPLETED
Conditions: Atopic Asthma
Interventions: PROCEDURE: Blood Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Relative Bioavailability of an Extemporaneous Oral Suspension of Aprepitant in Adolescents
Status: TERMINATED
Conditions: Nausea|Vomiting|Chemotherapy
Interventions: DRUG: Oral Aprepitant|DRUG: Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Interferon-Beta-1a and Estroprogestins Association in MS Patients
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: estroprogestins|DRUG: interferon-beta 1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: PhaseⅢOpen-label Study of MRA for Rheumatoid Arthritis(RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: MRA(Tocilizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Combined Omacor (Omega-3-acid Ethyl Esters) and Simvastatin Therapy in Hypertriglyceridemic Subjects
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Simvastatin|DRUG: Simvastatin + Lovaza
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Sugammadex in the Critically Ill
Status: UNKNOWN
Conditions: Critical Illness
Interventions: DRUG: Sugammadex|DRUG: Neostigmine|DRUG: Rocuronium|DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultra Sound Guided Fine Needle Aspiration Cytology (FNAC) of Liver and Pancreas Tumours
Status: SUSPENDED
Conditions: Tumors in Liver|Tumors in Pancreas
Interventions: PROCEDURE: FNAC (fine needle aspiration cytology)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Renal Sympathetic Denervation as Secondary Prevention for Patients After Percutaneous Coronary Intervention.
Status: UNKNOWN
Conditions: Coronary Heart Disease
Interventions: PROCEDURE: RSD|PROCEDURE: PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Metformin on Immunity
Status: COMPLETED
Conditions: Aging|Vaccine Response Impaired
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Gather Information About the Safety of Oral Anticoagulation Drugs and How Well These Drugs Work in Real World for Patients With Non-valvular Atrial Fibrillation (Irregularly Heart Beats Which is Not Caused by a Heart Valve Problem)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Rivaroxaban (Xarelto)|DRUG: Apixaban|DRUG: Dabigatran|DRUG: Warfarin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AlmegaPL CV Health Open Label Study
Status: COMPLETED
Conditions: Cholesterol|Triglycerides|Omega-3|Eicosapentaenoic Acid
Interventions: DIETARY_SUPPLEMENT: AlmegaPL (FDA NDIN # 826)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Laboratory-Treated T Cells in Treating Patients With High-Risk Relapsed Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia Previously Treated With Donor Stem Cell Transplant
Status: TERMINATED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Therapy-Related Acute Myeloid Leukemia|Donor|Hematopoietic Cell Transplant Recipient|HLA-A*0201 Positive Cells Present|Recurrent Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: WT1-Sensitized Allogeneic T-Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Co-Active Therapeutic Theatre (Co-ATT) for Dual-Diagnosis Patients
Status: NOT_YET_RECRUITING
Conditions: Mental Health Issue|Substance Use Disorders
Interventions: BEHAVIORAL: Co-Active Therapeutic Theatre (Co-ATT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Exercise in Subjects With Diastolic Heart Failure
Status: TERMINATED
Conditions: Diastolic Heart Failure
Interventions: DRUG: Alagebrium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aromatherapy on Pain, Anxiety and Satisfaction in Cannulation
Status: COMPLETED
Conditions: Hemodialysis Patients
Interventions: OTHER: aromatherapy|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: DEVICE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis
Status: NOT_YET_RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria|PNH|Extravascular Hemolysis
Interventions: DRUG: Danicopan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery
Status: COMPLETED
Conditions: Carotid Stenosis
Interventions: DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Delayed Coloanal Anastomosis for Medium and Lower Rectum Cancer Treatment. Phase 2 Clinical Trial (CASCADOR)
Status: COMPLETED
Conditions: Medium and Lower Rectal Cancer
Interventions: PROCEDURE: 2-stage pull-through colo-anal anastomosis without prophylactic derivation (2SCA)|PROCEDURE: Colo-anal anastomosis (CAA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT