pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Online Transtheoretic Model Based Health Education on Overweight University Students
Status: COMPLETED
Conditions: Public Health Nursing
Interventions: BEHAVIORAL: Health education on healthy nutrition and regular physical activity based on the transtheoretic model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Carboplatin, Paclitaxel, and Radiation Therapy With or Without Thalidomide in Patients With Stage III Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel|DRUG: thalidomide|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AF CRT +/- Nimorazole in HNSCC
Status: UNKNOWN
Conditions: Locally Advanced Head and Neck HPV Negative Squamous Cell Cancers
Interventions: DRUG: Cisplatin|RADIATION: Radiotherapy|DRUG: Placebo|DRUG: Nimorazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Kinesio Tape on Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Kinesiotape using Rocktape®|OTHER: Sham taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Various Degrees of Impaired Renal Function
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia Impact of Narcotic Free Anesthesia
Status: COMPLETED
Conditions: Pain, Postoperative|Breast Cancer|Postoperative Nausea and Vomiting
Interventions: DRUG: fentanyl|DRUG: beta-blocker (esmolol, metropolol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III Open Label Study of MEDI 4736 With/Without Tremelimumab Versus Standard of Care (SOC) in Recurrent/Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: MEDI4736|BIOLOGICAL: Tremelimumab|BIOLOGICAL: MEDI4736+Tremelimumab|BIOLOGICAL: Cetuximab|DRUG: 5-fluorouracil (5FU)|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study for the Safety and the Pharmacokinetics of DWJ1567 in Healthy Adult Volunteers
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: DWJ1567|DRUG: DWC202312
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to See How Well an Eye Drop, SURF-201, Works and What Side Effects There Are in Cataract Surgery Subjects
Status: COMPLETED
Conditions: Post-surgical Ocular Inflammation|Post-surgical Ocular Pain
Interventions: DRUG: SURF-201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IDP-118 Lotion in the Treatment of Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: IDP-118 Lotion|DRUG: Tazorac Cream|DRUG: IDP-118 Vehicle Lotion|DRUG: IDP-118 Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suture of UTerus and Ultrasound Repair Evaluation
Status: COMPLETED
Conditions: Uterine Scar Defect
Interventions: PROCEDURE: Closure of the hysterotomy at the time of primary cesarean
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Episealer® Knee System IDE Clinical Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Degenerative Lesion of Articular Cartilage of Knee
Interventions: DEVICE: Episealer Knee System|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Develop and Test the Effects of the 'Computer-Assisted OPD COPSCCP on Early Stage Lung Cancer Patients
Status: RECRUITING
Conditions: Lung Cancer
Interventions: OTHER: Experimental Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children
Status: UNKNOWN
Conditions: Otitis Media|Conductive Hearing Loss
Interventions: DEVICE: Ear Popper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients
Status: RECRUITING
Conditions: Refractory Solid Tumor|Hepatocellular Carcinoma|Malignant Solid Tumor|Pediatric Cancer|Pediatric Solid Tumor|Fibrolamellar Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Sorafenib|DRUG: Bevacizumab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Glossopharyngeal Versus Diaphragmatic Breathing Exercise on Pulmonary Function After Decortication Surgery
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Disease
Interventions: OTHER: traditional chest techniques|OTHER: Glossopharyngeal breathing exercise|OTHER: Diaphragmatic breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Methoxyflurane for Pain Management in Nasal Bone Fracture Reduction
Status: UNKNOWN
Conditions: Pain, Acute|Nasal Fracture
Interventions: PROCEDURE: Closed nasal fracture reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Acute Exacerbation in Subjects With COPD by Bacterial Decolonization in Lower Respiratory Tract
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DIETARY_SUPPLEMENT: oral probiotics|DRUG: aerosol inhaled amikacin|BIOLOGICAL: combined vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Memantine for Agitation in Dementia
Status: COMPLETED
Conditions: DEMENTIA
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Nebulized Dexmedetomidine on Hemodynamic Changes in Laparoscopic Bariatric Surgery.
Status: RECRUITING
Conditions: Dexmedetomidine|Hemodynamics|Laparoscopic Bariatric Surgery
Interventions: DRUG: Saline|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mode of Action Study of Vilaprisan and Ulipristal Acetate in Patients With Uterine Fibroids for Whom Surgery is Planned
Status: TERMINATED
Conditions: Leiomyoma
Interventions: DRUG: Vilaprisan, BAY1002670|DRUG: Ulipristal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, and Efficacy of Donepezil (Aricept) in Parkinson' s Disease (PD) Patients With Dementia
Status: COMPLETED
Conditions: Parkinson's Disease|Dementia
Interventions: DRUG: Prior Donepezil 5mg|DRUG: Prior Donzepezil 10mg|DRUG: Prior Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma
Status: RECRUITING
Conditions: Diffuse Astrocytoma, IDH-Wildtype|Recurrent Glioblastoma
Interventions: BIOLOGICAL: Atezolizumab|PROCEDURE: Biospecimen Collection|PROCEDURE: Conventional Surgery|RADIATION: Fractionated Stereotactic Radiation Therapy|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Methoxyflurane (Penthrox) for the Treatment of Acute Pain in Minor Trauma
Status: COMPLETED
Conditions: Acute Pain Due to Trauma
Interventions: DRUG: Methoxyflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantitative Evaluation of Aerosols Produced in the Dental Office
Status: COMPLETED
Conditions: Aerosol Disease|Caries,Dental
Interventions: PROCEDURE: Caries treatment with a dental turbine|PROCEDURE: Caries treatment with Er:YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Honey and Dexamethason on Extraction Healing
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: DRUG: Normal saline|DRUG: Dexamethasone|DRUG: Honey|DRUG: Dexamethasone and honey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peptide-Pulsed Dendritic Cell Vaccination in Combination With Nivolumab and Ipilimumab for the Treatment of Recurrent and/or Progressive Diffuse Hemispheric Glioma, H3 G34-mutant
Status: NOT_YET_RECRUITING
Conditions: Diffuse Hemispheric Glioma, H3 G34-Mutant
Interventions: BIOLOGICAL: Dendritic Cell Tumor Peptide Vaccine|BIOLOGICAL: Ipilimumab|PROCEDURE: Leukapheresis|BIOLOGICAL: Nivolumab|DRUG: Placebo Administration|DRUG: Placebo Administration|DRUG: Poly ICLC|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Evaluating the Safety and Performance of the GeNO NITROsyl Delivery System for Inhaled Nitric Oxide
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Nitric Oxide generated by the GeNO nitrosyl delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Lowest Effective Dose of Dexmedetomidine in Attenuating the Hemodynamic Responses During Skull Pin Insertion in Patients Undergoing Elective Craniotomy
Status: UNKNOWN
Conditions: Skull Pin Insertion
Interventions: DRUG: Dexmedetomidine Injection [Precedex]|OTHER: normal saline 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety Study of Fuganlin Oral Liquid in Children With Influenza (Acute Upper Respiratory Infection)
Status: COMPLETED
Conditions: Acute Upper Respiratory Infection
Interventions: DRUG: Fuganlin Oral Liquid|DRUG: Xiaoer Jiebiao Oral Liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Binge Drinking of Alcohol Mixed With Energy Drinks
Status: UNKNOWN
Conditions: Healthy|Alcohol Drinking
Interventions: DIETARY_SUPPLEMENT: Alcohol and Energy Drink (AmED)|DIETARY_SUPPLEMENT: Alcohol and Energy drink Placebo|DIETARY_SUPPLEMENT: Alcohol placebo and Energy drink|DIETARY_SUPPLEMENT: Alcohol placebo and energy drink placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Online Psychosocial Cancer Screening, Monitoring and Stepped Treatment in Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Psychological Distress|Emotional Disorder
Interventions: BEHAVIORAL: Online integrated and stepped psychosocial care|BEHAVIORAL: Usual psychosocial care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expression of Pro- and Anti-inflammatory Cytokines During Anti-PCSK9 in Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia, Familial
Interventions: DRUG: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigational Imaging Technique During Brain Surgery
Status: NOT_YET_RECRUITING
Conditions: Astrocytoma|Glioblastoma|Oligodendroglioma
Interventions: PROCEDURE: Craniotomy|DEVICE: Quantitative Oblique Back-Illumination Microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Eye Exercises on Visual Function and Quality of Life After Multifocal Intraocular Lens Implantation
Status: NOT_YET_RECRUITING
Conditions: Cataract|Intraocular Lenses
Interventions: OTHER: Eye Exercise|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Goat or Cow Milk Based Infant Formula GMS
Status: RECRUITING
Conditions: Growth
Interventions: OTHER: Advance Infant Formula Powder|OTHER: "Kendamil Cow milk test product|OTHER: "Kendamil goat milk test product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Topical Tranexamic Acid (TXA) in Joint Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Hip Arthropathy|Shoulder Arthropathy
Interventions: BIOLOGICAL: Tranexamic acid (TXA)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing and Approaching Crises for Frail Community-dwelling Patients Through Through Innovative Care (PRACTIC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Frailty
Interventions: OTHER: TIME model in the prevention and treatment of crises in frail community-dwelling people
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High Dose Lurasidone for Patients With Treatment Resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Lurasidone|DRUG: Lurasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Parenteral Testosterone and Oral Etoposide as Therapy for Men With Castration Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Testosterone injection|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Tolerance and Lower-limb Muscle Power in Patients With Chronic Respiratory Disease
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Fibrosis|Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Functional capacity tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reduction of Groin Wound Infections After Vascular Surgery by Using an Incision Management System (IMS)
Status: COMPLETED
Conditions: Infections
Interventions: DEVICE: Prevena™ IMS|OTHER: sterile plaster dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of NM8074 in Patients With aHUS With Evidence of Ongoing Thrombotic Microangiopathy
Status: NOT_YET_RECRUITING
Conditions: aHUS - Atypical Hemolytic Uremic Syndrome
Interventions: DRUG: NM8074
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism.
Status: COMPLETED
Conditions: Hypoparathyroidism
Interventions: OTHER: Liquid meal (Nutridrink)|OTHER: GIP|OTHER: GLP-2|OTHER: Placebo (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Recovery of Short-term Renal Function in Post-transplant Patients Living Donor
Status: COMPLETED
Conditions: Nephrectomy
Interventions: PROCEDURE: Open nephrectomy|PROCEDURE: Hand-assisted laparoscopic nephrectomy|PROCEDURE: Laparoscopic nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing the A in SAFE for Trachoma
Status: COMPLETED
Conditions: Trachoma
Interventions: DRUG: Azithromycin for Routine Community-wide MDA|DRUG: Two Additional Rounds of Azithromycin for Children|DRUG: Azithromycin for Second Community-wide MDA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Bisphosphonates in Patients With Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome
Status: COMPLETED
Conditions: SAPHO Syndrome
Interventions: DRUG: pamidronate disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surfactant Replacement Guided by Early Lung Ultrasound Score in Preterm Newborns With Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Preterm Birth
Interventions: DRUG: Surfactant administration until 2020|DRUG: Surfactant administration since 2021
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Increasing Effective Mental Health Care for LGBT Clients
Status: ENROLLING_BY_INVITATION
Conditions: Sexual Orientation|Gender Identity
Interventions: BEHAVIORAL: Face-to-face and online LGBTQ+ training|BEHAVIORAL: On-line training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ambulatory Blood Pressure Monitoring in Oral Testosterone Undecanoate (TU, LPCN 1021) Treated Hypogonadal Men
Status: COMPLETED
Conditions: Hypogonadism, Male
Interventions: DRUG: LPCN 1021
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery
Status: UNKNOWN
Conditions: Endoscopic Sinus Surgery
Interventions: DRUG: Propofol infusion|DRUG: Magnesium Sulfate infusion|DRUG: Lidocaine|DRUG: Fentanyl|DRUG: Propofol|DRUG: Atracurium|PROCEDURE: Mechanical Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dendritic Killer Cell-based Immunotherapy for Solid Tumors
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Hepatocellular Carcinoma|Neoplasm Metastasis
Interventions: BIOLOGICAL: Dendritic Killer Cell (DKC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UT-15C SR in the Treatment of Critical Limb Ischemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia
Interventions: DRUG: UT-15C SR (treprostinil diethanolamine) 1mg oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carie Care, Chemomechanical Caries Removal Technique in Primary Teeth
Status: UNKNOWN
Conditions: Dental Caries|Primary Teeth
Interventions: OTHER: Chemomechanical caries removal by Carie-Care|OTHER: Mechanical caries removal by Atraumatic Restorative Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: [18F]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma
Status: RECRUITING
Conditions: Invasive Lobular Breast Carcinoma
Interventions: DRUG: [18F]Fluoroestradiol (FES) PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Methylphenidate Late Formula to Reduce Cannabis Use in Young Cannabis-Related Patients and Attention Deficit Disorder Hyperactivity
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: Methylphenidate|OTHER: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of BOTOX® for the Management of Urinary Incontinence in Patients With Idiopathic Overactive Bladder
Status: COMPLETED
Conditions: Urinary Incontinence|Urinary Bladder, Overactive
Interventions: BIOLOGICAL: botulinum toxin Type A
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing Counseling and Mobile Health Interventions to Improve Physical Activity and Diet Quality in Survivors of Childhood Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|BEHAVIORAL: Behavioral Intervention|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Effects of Oscillatory Mobilizations and Mckenzie Retraction Exercises on Mechanical Neck Pain
Status: UNKNOWN
Conditions: Mechanical Neck Pain
Interventions: OTHER: Oscillatory Mobilization|OTHER: Mckenzie Retraction Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Quadrivalent Influenza Virus Split Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: 0.5ml Quadrivalent influenza vaccine|BIOLOGICAL: 0.25ml Quadrivalent influenza vaccine|BIOLOGICAL: 0.25ml Trivalent influenza vaccine(B/V)|BIOLOGICAL: 0.25ml Trivalent influenza vaccine(B/Y)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hemiarthroplasty Versus Total Hip Replacement for Intracapsular Hip Fractures
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DEVICE: Hemiarthroplasty|DEVICE: Total hip arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2 Study of Decitabine and Venetoclax in Combination With the Targeted Mutant IDH1 Inhibitor Olutasidenib
Status: RECRUITING
Conditions: Mutant IDH1 Inhibitor Olutasidenib
Interventions: DRUG: Olutasidenib|DRUG: Venetoclax|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of Single Doses of GSK189075 in Subjects With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: GSK189075|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial of CinnaGen COVID-19 Vaccine (SpikoGen)
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: SARS-CoV-2 recombinant spike protein + Advax-SM adjuvant|BIOLOGICAL: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment
Status: COMPLETED
Conditions: Adjunctive Treatment of Major Depressive Disorder
Interventions: DRUG: Pimavanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases
Status: RECRUITING
Conditions: Adaptive Radiotherapy|Stereotactic Body Radiotherapy|Non-small Cell Lung Cancer|Lung Oligometastases|Toxicity
Interventions: RADIATION: Online adaptive SBRT|RADIATION: Conventional SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
Status: COMPLETED
Conditions: Diabetes Mellitus|Local Anesthesia
Interventions: DRUG: L+C maxillary anesthesia|DRUG: L+C mandibular anesthesia|DRUG: L+E maxillary anesthesia|DRUG: L+E mandibular anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety And Efficacy Of Sunitinib In Chinese Patients With Progressive Advanced Or Metastatic Well-Differentiated Unresectable Pancreatic Neuroendocrine Tumors
Status: COMPLETED
Conditions: Pancreatic Neuroendocrine Tumors
Interventions: DRUG: sunitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis
Status: COMPLETED
Conditions: HIV Infections|Histoplasmosis|Blastomycosis
Interventions: DRUG: Itraconazole|DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Impact of Exposure to Persistent Organic Pollutants During Pregnancy on the Composition of Breast Milk and Consequences on the Newborn
Status: COMPLETED
Conditions: Pesticide|Breast Milk|Pollution; Exposure|Meconium|Stool|Microbiota|Newborn
Interventions: BIOLOGICAL: breast milk collection|BIOLOGICAL: meconium collection|BIOLOGICAL: newborn feces collection|OTHER: questionary of pesticide exposure of the mother
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Continuous Glucose Sensors by Adolescents With Inadequate Diabetic Control
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Continuous Glucose Sensor|OTHER: Standard Care|BEHAVIORAL: CGS + Behavior Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The PRECISION Study: 3 Fractions of Prostate SBRT and RayPilot HypoCath Image Guidance
Status: NOT_YET_RECRUITING
Conditions: Localized Prostate Cancer|Low Risk Prostate Cancer|Intermediate Risk Prostate Cancer
Interventions: RADIATION: 3 fractions of prostate SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flurbiprofen Axetil as an Adjuvant to Pre-emptive Scalp Infiltration
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: FA plus ropivacaine|DRUG: ropivacaine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of Topical Oxybutynin 10% for Treating Primary Focal Hyperhidrosis-axillary, Palmar and Plantar.
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: Oxybutynin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation and Safety Study of I5NP in Patients Undergoing Major Cardiovascular Surgery
Status: COMPLETED
Conditions: Injury of Kidney|Acute Renal Failure
Interventions: DRUG: I5NP (a small interfering RNA)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis
Status: COMPLETED
Conditions: Prostate Cancer Patients With Bone Metastasis
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Reducing Indoor Air Pollution on the Adult Asthmatic Response
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: High Efficiency Particulate Air Cleaner|DEVICE: Sham air cleaner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Botulinum Toxin Type A in Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: botulinum toxin A|DRUG: Gabapentin|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heavy Bupivacaine in Peribulbar Block
Status: UNKNOWN
Conditions: Anesthetics, Local
Interventions: DRUG: hyperbaric bupvacaine in Peribulbar block|DRUG: isobaric bupvacaine in Peribulbar block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of a Maintenance Strategy With Protease Inhibitors With or Without Lamivudine in Virologically Suppressed HIV Patients on Second Line Antiretroviral Treatment in Africa
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: monoPI - boosted lopinavir or boosted darunavir|DRUG: bi therapy - (boosted lopinavir or boosted darunavir) + lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Coronary Revascularization Surgery With Injection of WJ-MSCs and Placement of an Epicardial Extracellular Matrix
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Heart Failure|Coronary Artery Disease|Mesenchymal Stem Cell Transplantation|Regenerative Medicine
Interventions: BIOLOGICAL: Wharton's jelly-derived mesenchymal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib in Treating Patients Who Are Undergoing Surgery for Metastatic Kidney Cancer
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: PROCEDURE: therapeutic conventional surgery|DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Clinical Activity of GSK525762 Plus Trametinib in Subjects With Solid Tumors
Status: WITHDRAWN
Conditions: Solid Tumours
Interventions: DRUG: GSK525762 Besylate tablets|DRUG: Trametinib tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Elranatamab (PF-06863135)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sildenafil in Treating Erectile Dysfunction in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Psychosocial Effects of Cancer and Its Treatment|Radiation Toxicity|Sexual Dysfunction|Sexuality and Reproductive Issues
Interventions: DRUG: sildenafil citrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: WIREDUP: Wearable Insoles for Recurrent Diabetic Ulcer Prevention
Status: NOT_YET_RECRUITING
Conditions: Diabetes|Peripheral Neuropathy|Diabetic Foot|Diabetic Foot Ulcer
Interventions: DEVICE: Orpyx SI Sensory Insole System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Chronic Kidney Insufficiency|Chronic Renal Diseases|Chronic Renal Insufficiency|Kidney Insufficiency, Chronic|C-Reactive Protein|High Sensitivity C-Reactive Protein|Hs-CRP|hsCRP
Interventions: DRUG: TOUR006 - 50 MG|DRUG: TOUR006 - 25 MG|DRUG: TOUR006 - 15 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wells and Enteric Disease Transmission Trial (WET - Trial)
Status: UNKNOWN
Conditions: Gastrointestinal Infection|Respiratory Viral Infection
Interventions: DEVICE: Active household UV water treatment device|DEVICE: Inactive household UV water treatment device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Placebo-Controlled, Dose-Escalating Study to Examine the Safety and Tolerability of Single Intravenous Doses of CF-301 in Healthy Subjects
Status: COMPLETED
Conditions: Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
Interventions: DRUG: CF-301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrocodone For Pain Control in First Trimester Surgical Abortion
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Hydrocodone/acetaminophen|DRUG: Placebo|DRUG: Ibuprofen|DRUG: Lorazepam|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nilotinib ± Peg-IFN for First Line Chronic Phase CML Patients
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Nilotinib (Tasigna ®), capsules of 150 mg|DRUG: Nilotinib (Tasigna ®) and Pegylated interferon alfa 2a (Pegasys®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Open-label, Two-arms, Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Mediastinal B-cell Lymphoma
Interventions: OTHER: observation|RADIATION: 3D-Conformal Radiotherapy (3D-CRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Gas Flow in Transnasal Pulmonary Aerosol Delivery: A Double-blinded, Randomized Controlled Trial
Status: COMPLETED
Conditions: COPD Asthma
Interventions: OTHER: nasal cannula gas flow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: CBT-Eb Plus EMDR Versus CBT-Eb in Patients With Eating Disorders
Status: UNKNOWN
Conditions: Eating Disorder
Interventions: BEHAVIORAL: EMDR|BEHAVIORAL: CBT-Eb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Fibrin Sealant (FS 4IU) for Skin Graft Fixation and Wound Healing in Subjects With Burn Wounds
Status: COMPLETED
Conditions: Burns
Interventions: DRUG: Sheet skin grafts affixed with Fibrin Sealant (lyophilized) with 4 IU/mL Thrombin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD
Status: TERMINATED
Conditions: Light Chain Deposition Disease|Primary Systemic Amyloidosis
Interventions: DRUG: pomalidomide|DRUG: bortezomib|DRUG: dexamethasone|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alveolar Bone Dehiscence and Fenestration Following Accelerated Maxillary Canine Retraction
Status: RECRUITING
Conditions: Fenestration|Dehiscence
Interventions: PROCEDURE: PRP injection|PROCEDURE: Combined decortication and PRP injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Protocol for Reconstruction of Anterior Cruciate Ligament and Anterolateral Knee Ligament Surgery
Status: UNKNOWN
Conditions: Anterior Cruciate Ligament Reconstruction|Anterolateral Ligament Reconstruction|Rehabilitation
Interventions: OTHER: partial knee immobilization protocol|OTHER: standard ACL reconstruction rehabilitation protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Niagen™|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Toripalimab as Consolidation Therapy After Postoperative Chemoradiotherapy in HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinomas
Interventions: DRUG: Consolidation Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib in Combination With PD1 With Gemcitabine Plus(+)Cisplatin for Unresectable or Metastatic Biliary Tract Cancer
Status: UNKNOWN
Conditions: Biliary Tract Cancer
Interventions: DRUG: Anlotinib Hydrochloride in Combination With PD1 With Gemcitabine Plus(+)Cisplatin|DRUG: Gemcitabine Plus(+)Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms
Status: RECRUITING
Conditions: Myeloproliferative Neoplasms
Interventions: DRUG: INCA033989|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jaktinib Hydrochloride Tablets In The Treatment of Active Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Jaktinib Hydrochloride Tablets|DRUG: Jaktinib Hydrochloride Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-0869 (Aprepitant) and MK-0517 (Fosaprepitant) in Pediatric Participants Receiving Chemotherapy (MK-0869-134)
Status: TERMINATED
Conditions: Chemotherapy-Induced Nausea and Vomiting
Interventions: DRUG: Experimental: aprepitant|DRUG: Experimental: fosaprepitant|DRUG: Comparator: ondansetron|DRUG: Ondansetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Investigation to Evaluate The Orkla Corn Plaster
Status: COMPLETED
Conditions: Corns
Interventions: COMBINATION_PRODUCT: Orkla Corn Plaster with salicylic acid|DEVICE: Orkla Corn Protector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiestrogen vs Aromatase Inhibitor After Adjuvant Chemotherapy for Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Toremifene citrate|DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Safety Study of Transdermal Testosterone (300 Mcg/Day) in Naturally Postmenopausal Women
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: Testosterone Transdermal System|DRUG: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROFIT - Prostate Fractionated Irradiation Trial
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: 7800 cGy/39 fractions in 8 weeks|PROCEDURE: 6000 cGy/20 fractions in 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Nemtabrutinib|DRUG: Ibrutinib|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Epidural Analgesia and Bilateral Erector Spinae Plane Block on Postoperative Pain in Open Heart Surgeries
Status: COMPLETED
Conditions: Pain, Postoperative|Respiratory Complication
Interventions: PROCEDURE: Thoracic epidural analgesia|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Nano-Ivermectin Impregnated Masks in Prevention of Covid-19 Among Healthy Contacts and Medical Staff
Status: UNKNOWN
Conditions: Covid-19
Interventions: OTHER: ivermectin impregnated mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Generation of Positive Biological Samples to Leuprolide Acetate for Doping Control
Status: COMPLETED
Conditions: There Are no Conditions Under Study. Healthy Volunteers
Interventions: DRUG: LEUPRORELIN ACETATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pasireotide (SOM230) With or Without Everolimus in Treating Patients With Hormone Resistant, Chemotherapy Naive Prostate Cancer
Status: TERMINATED
Conditions: Castrate Resistant Prostate Cancer|Chemotherapy Naive Prostate Cancer|Prostate Cancer
Interventions: DRUG: Pasireotide|DRUG: Everolimus|OTHER: Laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Description of Bullous Emphysema Using Lung Ultrasound and Comparison to the Characteristics of Pneumothorax
Status: COMPLETED
Conditions: Pulmonary Emphysema
Interventions: DIAGNOSTIC_TEST: Lung ultrasound|DIAGNOSTIC_TEST: Chest radiography|DIAGNOSTIC_TEST: Pulmonary function tests|OTHER: Clinical examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Irritable Bowel Syndrome and Lactibiane Tolerance
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Lactibiane Tolerance|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT