pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Theory Driven, Rurally Tailored, Family-Based, Telehealth Intervention for Childhood Obesity
Status: COMPLETED
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: Newsletters|BEHAVIORAL: Family-based Telehealth Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tiotropium Handihaler vs. Tiotropium Respimat in COPD
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: tiotropium bromide inhalation powder (Spiriva HandiHaler)|DRUG: tiotropium bromide (Spiriva Respimat)|DRUG: Hyperpolarized 129XeMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in PD Patients
Status: COMPLETED
Conditions: Idiopathic Parkinson Disease
Interventions: OTHER: NeuraLight software-based platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children
Status: COMPLETED
Conditions: Dyspepsia|Malabsorption Syndrome|Gastroesophageal Reflux Disease|Abdominal Pain
Interventions: DRUG: Lidocaine|DRUG: Tannic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Randomized, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Efficacy and Safety of Fostamatinib in COVID-19 Subjects
Status: COMPLETED
Conditions: Covid19|SARS (Severe Acute Respiratory Syndrome)|SARS Pneumonia|SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere|Pneumonia|Pneumonia, Viral
Interventions: DRUG: Fostamatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Drug-Coated Balloon for De-novo Lesions in Patients With Acute Coronary Syndromes (DCB-ACS)
Status: COMPLETED
Conditions: Drug-Coated Balloon|De Novo Stenosis|Acute Coronary Syndromes|ACS|DCB|Clinical Trial|Coronary Artery Disease
Interventions: DEVICE: Drug-coated balloon|DEVICE: Zotarolimus-Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Methotrexate Carried by a Lipid Nanoemulsion on Left Ventricular Remodeling After STEMI
Status: TERMINATED
Conditions: Myocardial Infarction, Anterior Wall|Myocardial Remodeling, Ventricular
Interventions: DRUG: Methotrexate|DRUG: Placebo|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Glyco pMDI After Single and Repeated Administration
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Glycopyrrolate|DRUG: Tiotropium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Discontinuation of disease modifying therapy|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: exemestane|DRUG: tamoxifen|DRUG: triptorelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Cyclosporine Ophthalmic Emulsion in Post-LASIK Patients
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Cyclosporine Ophthalmic Emulsion 0.05% (RESTASIS®)|DRUG: Artificial Tears REFRESH ENDURA®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study That Will Evaluate How Well SEP-363856 Works and How Safe it is in People With Schizophrenia That Switch to SEP-363856 From Their Current Antipsychotic Medication
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: SEP-363856
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Chronic Low Back Pain in Older Adults Using Auricular Point Acupressure
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: Target ear points related to chronic low back pain (T-APA)|OTHER: Non-Target ear Points not related to chronic low back pain (NT-APA)|OTHER: Enhanced Educational Control Group (CG-2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Absorbance Study - Clinical Trial of the Absorbance of Nano Liquid D3
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Softgel Vitamin D3|DIETARY_SUPPLEMENT: Nano Liquid Vitamin D3|DIAGNOSTIC_TEST: 25(OH)D Blood Serum Test|OTHER: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Adderall-XR and Topiramate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Procedure for Duodenal-Ileal Diversion With a Sleeve Gastrectomy for Patients With Obesity and Type 2 Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Type 2 Diabetes Mellitus
Interventions: DEVICE: Self Forming Magnetic (SFM) Anastomosis System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: COMBINATION_PRODUCT: Cingal|DEVICE: Monovisc|DRUG: Triamcinolone Hexacetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290 In Combination With Cibisatamab With Obinutuzumab Pre-Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: RO7122290|DRUG: Cibisatamab|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Prospective Study of Selective Laser Trabeculoplasty (SLT) Versus Argon Trabeculoplasty (ALT) in Patients With Pseudoexfoliation Glaucoma and Ocular Hypertension
Status: COMPLETED
Conditions: Exfoliation Syndrome|Ocular Hypertension
Interventions: PROCEDURE: SLT|PROCEDURE: ALT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MHAB5553A in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: MHAB5553A|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Different Methods for Modulating Postprandial Fat Oxidation on Postprandial Lipemia the Next Day
Status: COMPLETED
Conditions: Time-restricted Feeding|Postprandial Lipemia
Interventions: OTHER: time-restricted feeding trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sugars-sweetened Commercial Beverages on Short-term Food Intake
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Water|DIETARY_SUPPLEMENT: Fruit drink|DIETARY_SUPPLEMENT: Cola|DIETARY_SUPPLEMENT: 1% chocolate milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to the Regional Nodes for Advanced Stage, Human Papilloma Virus (HPV) Positive, Oropharyngeal Cancer
Status: COMPLETED
Conditions: Oropharyngeal Cancer
Interventions: PROCEDURE: TORS|RADIATION: Adjuvant Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: tACS and tRNS Studies on Brain Control of Swallowing
Status: COMPLETED
Conditions: Dysphagia|Swallowing Disorder
Interventions: DEVICE: Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy in Mature Permanent Molars With Irreversible Pulpitis
Status: RECRUITING
Conditions: Irreversible Pulpitis
Interventions: OTHER: Epigallocatechin gallate (EGCG)|OTHER: Sodium hypochlorite (NaOCl)|OTHER: Mineral trioxide aggregate (MTA)|OTHER: Premixed bioceramic putty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Relative Bioavailability of Fixed-Dose Combination (FDC) Tablet (Simeprevir, Odalasvir and AL-335) Compared With Single Agents Administered Together, and to Assess the Effect of Multiple-Dose Lansoprazole or Omeprazole on Single-Dose Pharmacokinetics of SMV, ODV, and AL-335 (FDC)
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Simeprevir 75 mg|DRUG: Odalasvir 25 mg|DRUG: Odalasvir 12.5 mg|DRUG: Odalasvir 75 mg|DRUG: AL-335 800 mg|DRUG: Lansoprazole 30 mg|DRUG: Omeprazole 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Levosimendan Improvement of Prognosis of ARDS Patients by Optimizing Pulmonary Hemodynamics
Status: UNKNOWN
Conditions: ARDS, Human
Interventions: DRUG: Levosimendan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Xeloda (Capecitabine) in Combination With Avastin + Short Course Chemotherapy in Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine [Xeloda]|DRUG: capecitabine [Xeloda]|DRUG: bevacizumab [Avastin]|DRUG: oxaliplatin|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Wound Catheter Analgesia Associated With Intravenous Morphine PCA After Thoracotomy
Status: COMPLETED
Conditions: Pain|Thoracotomy
Interventions: DRUG: ropivacaine 0.75% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)|DRUG: Placebo|DRUG: ropivacaine 0.2% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prognostic Implications of AccuFFRangio-guided PCI in STEMI
Status: UNKNOWN
Conditions: Coronary Artery Disease|ST Elevation Myocardial Infarction
Interventions: OTHER: AccuFFRangio-guided strategy|OTHER: Angiography-guided strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Peritonsillar Infiltration of Tramadol Ketamine and Placebo on Pediatric Posttonsillectomy Pain
Status: UNKNOWN
Conditions: Sleep Disorder; Breathing-Related|Pain, Postoperative|Child, Only
Interventions: DRUG: Tramadol|DRUG: Ketamine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants
Status: RECRUITING
Conditions: Diarrhoea
Interventions: DRUG: altSonflex Placebo|BIOLOGICAL: altSonflex1-2-3 Dose C|BIOLOGICAL: altSonflex1-2-3 Dose B|BIOLOGICAL: altSonflex1-2-3 Dose A|BIOLOGICAL: GSK's Meningococcal A, C, Y and W-135 conjugate vaccine|COMBINATION_PRODUCT: GSK's Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine|COMBINATION_PRODUCT: GSK's Diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis (inactivated), and Haemophilus influenzae type b vaccine|COMBINATION_PRODUCT: Sanofi Pasteur's Typhoid Vi polysaccharide vaccine|BIOLOGICAL: Serum Institute of India's Measles and rubella vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: This Study in Healthy Men and Women Tests Whether BI 409306 Has an Effect on the ECG (Thorough QT Study)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 409306|DRUG: Moxifloxacin|DRUG: Placebo matching to BI 409306
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: hydroxychloroquine|DRUG: temozolomide|OTHER: pharmacological study|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Anlotinib Combined With Allitinib in Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: Anlotinib Hydrochloride Capsule Combined with Allitinib Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Learning From Falling: Perturbation-based Training to Prevent Falls in Older Adults
Status: COMPLETED
Conditions: Accidental Falls
Interventions: BEHAVIORAL: Balance recovery|BEHAVIORAL: Postural Sway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endoscopic Ultrasound Guided Radiofrequency Ablation (EUS-RFA) for Small Benign Pancreatic Tumors
Status: WITHDRAWN
Conditions: Neuroendocrine Tumors|Cystic Neoplasms
Interventions: DEVICE: endoscopic ultrasound - radiofrequency ablation (EUS-RFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP)
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DEVICE: Goldmann and Perkins applanation tonometry|DRUG: TAFLUPROST 0.0015% EYEDROPS|DRUG: LATANOPROST 0.005% EYEDROPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma (REDEFINE Study)
Status: COMPLETED
Conditions: COPD Asthma
Interventions: DEVICE: Spirometry at initial visit|DRUG: Albuterol|DEVICE: Spirometry at 12-month follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Hemodynamic Effect Between Two Types of Anesthesia in Esophageal Surgery
Status: COMPLETED
Conditions: Epidural Block|Oesophageal Cancer|Oesophagectomy
Interventions: OTHER: paravertebral block|OTHER: thoracic epidural block|DRUG: ropivacaine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Addition of Dexamethasone to Transversus Abdominis Plane (TAP) Peripheral Nerve Block
Status: COMPLETED
Conditions: Prostate CA
Interventions: DRUG: Dexamethasone|PROCEDURE: TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT of Nintedanib in Fibrotic Sarcoidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoidosis, Pulmonary
Interventions: DRUG: Nintedanib|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imuran Dosing in Crohn's Disease Study
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Azathioprine weight-based dose|DRUG: Azathioprine individualised dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Biomarkers to Predict CNS Involvement in Diffuse Large B-Cell Lymphoma: a Danish Nationwide Registry Study
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma|Diffuse Large B-Cell Lymphoma Cell of Origin|Diffuse Large B-cell Lymphoma Recurrent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)
Status: NOT_YET_RECRUITING
Conditions: Adenocarcinoma of the Bladder|Squamous Cell Carcinoma of the Bladder|Testicular Germ Cell Tumors
Interventions: DRUG: Pembrolizumab|DRUG: Enfortumab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flavopiridol in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: alvocidib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-FDG and 68Ga-FAPI PET/CT in Crohn's Disease
Status: UNKNOWN
Conditions: Crohn Disease
Interventions: DIAGNOSTIC_TEST: 18F-FDG and 68Ga-FAPI PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Exercise Induced Bronchoconstriction Using a Novel Automated Digital Clinical Decision System
Status: UNKNOWN
Conditions: Exercise Induced Asthma|Exercise Induced Bronchospasm|Pediatric Respiratory Diseases
Interventions: DIAGNOSTIC_TEST: AsthmaTuner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Learn About the Study Medication, Zavegepant, in Healthy Volunteers
Status: COMPLETED
Conditions: Biological Availability
Interventions: DRUG: Zavegepant 100mg non-enteric coated soft gel capsule|DRUG: Zavegepant 100mg immediate release tablet|DRUG: Zavegepant 2 x 100mg immediate release tablets|DRUG: Zavegepant 4 x 25mg enteric coated soft gel capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vaginal Progesterone to Prevent Preterm Delivery in Women With Preterm Labor
Status: TERMINATED
Conditions: Preterm Delivery|Morbidity|Perinatal Mortality
Interventions: DRUG: progesterone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Safety and Pharmacokinetics of Single and Multiple Oral Doses of AZD4316 in Healthy Subjects
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: AZD4316|DRUG: AZD4316|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Escalation Trial of Dalotuzumab (MK-0646) in Advanced Solid Tumors and Multiple Myeloma (MK-0646-001)
Status: COMPLETED
Conditions: Solid Tumor|Multiple Myeloma
Interventions: DRUG: Dalotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|PTSD|Depression|Anxiety Disorder
Interventions: DRUG: Midazolam|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Cervical Cancer Screening in Mayuge District Uganda (ASPIRE Mayuge)
Status: COMPLETED
Conditions: Human Papillomavirus 16|Human Papillomavirus 18|Papillomavirus Infections|Cervical Cancer|Pre-Cancerous Dysplasia
Interventions: BEHAVIORAL: Self-collected HPV testing for cervical cancer screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Clinical Trial to Explore the Efficacy and Safety of DA-4001 After Topical Application
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: DA-4001C|DRUG: 5% minoxidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone
Status: RECRUITING
Conditions: Respiratory Distress Syndrome|Ventilation Therapy; Complications
Interventions: BEHAVIORAL: With and Without Awake Prone Positioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Cisplatin Plus Gemcitabine Induction Chemotherapy and Intensity-modulated radiotherapyIntensity-modulated Radiotherapy With or Without Concurrent Cisplatin for NPC
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Inductive chemotherapy + concurrent cisplatin and IMRT|DRUG: Inductive chemotherapy + IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Using Placenta Derived Decidual Stromal Cells for Toxicity and Inflammation With Special Focus to the Allogeneic Hematopoietic Cell Transplantation Setting
Status: UNKNOWN
Conditions: Acute Lung Injury|Decidual Stromal Cells|Stem Cell Transplantation|Inflammation
Interventions: BIOLOGICAL: Decidual stromal cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CBM in the Context of Exposure for Acrophobia
Status: COMPLETED
Conditions: Acrophobia
Interventions: BEHAVIORAL: One session exposure treatment|BEHAVIORAL: Sham Cognitive Bias Modification training|BEHAVIORAL: Active Cognitive Bias Modification training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methadone Demonstration Project With Neonatal Intensive Care Unit Infants Diagnosed With Neonatal Abstinence Syndrome
Status: TERMINATED
Conditions: Neonatal Abstinence Syndrome
Interventions: DRUG: Methadone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Personalized Genomic Vaccine and Tumor Treating Fields (TTFields) to Treat Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Poly-ICLC|DEVICE: Tumor Treating Fields|BIOLOGICAL: Peptides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Metformin and S. Baicalensis Combination Therapy in Type 2 Diabetes Mellitus Patients
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: DRUG: Combination of Metformin + S. Baicalensis|DRUG: Combination of Metformin + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PaneLux PTCA : Proposing an Alternative Treatment to patiEnts for Whom DES Implantation is Not Indicated, Thanks to Pantera LUX Drug Eluting Balloon
Status: UNKNOWN
Conditions: Coronary Artery Disease|High Bleeding Risk Patients
Interventions: DEVICE: Pantera Lux Drug Eluting Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy or Observation Following Surgery in Treating Infants With Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: vincristine sulfate|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety, Effectiveness & Usability of the XACT Robotic System for Image Guided Percutaneous Procedures
Status: COMPLETED
Conditions: CT-guided Minimally Invasive Procedures e.g., Biopsies
Interventions: DEVICE: XACT Robotic System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a High-Dose Aflibercept in Participants With Diabetic Eye Disease
Status: COMPLETED
Conditions: Diabetic Macular Edema|Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: aflibercept|DRUG: High-dose aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Ventricular Arrhythmia Risk After CRT-D Replacement for Patients With Primary Prevention Indication
Status: COMPLETED
Conditions: Cardiac Resynchronization|Biventricular Pacemakers, Artificial|Cardioverter-Defibrillators, Implantable|Device Replacement
Interventions: DEVICE: CRT-D device replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Controlled Trial of Protein Enrichment of Meal Replacements for Weight Reduction With Retention of Lean Body Mass
Status: COMPLETED
Conditions: Weight Loss|Obesity
Interventions: DIETARY_SUPPLEMENT: high protein|DIETARY_SUPPLEMENT: standard protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) Assessment of LIK066 in Healthy Subjects and in Patients With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: LIK066|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: ketorolac 0.4%, bromfenac 0.09%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Quadriceps Muscle Electrostimulation Used in Patients Suffering From Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis|Mucoviscidosis
Interventions: BEHAVIORAL: Electrostimulation programme: using a cycloergometer|BEHAVIORAL: Usual sport activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: An Opioid Prescribing Nudge
Status: COMPLETED
Conditions: Opioid Use, Unspecified|Prescription Drug Abuse (Not Dependent)|Prescription Drug Abuse and Dependency|Health Behavior|Benzodiazepine Abuse|Benzodiazepine Dependent
Interventions: OTHER: Automated Reports on prescription patterns for their patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Endometriosis of the Recto-sigmoid: MRI (Magnetic Resonance Imaging) Criteria Predictive of Shaving or Segmental Resection
Status: COMPLETED
Conditions: Endometriotic Parietal Involvement of the Rectosigmoid
Interventions: OTHER: MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Less to Hold - A Comparison of Bladder Toxicities (Side Effects) in Patients Undergoing Prostate Radiotherapy Between Patients Treated With Empty Bladder and Those on a Drinking Protocol.
Status: COMPLETED
Conditions: Prostate Cancer|Radiotherapy Side Effect
Interventions: BEHAVIORAL: Empty bladder|BEHAVIORAL: Full bladder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial of Oral Karenitecin in Patients With Solid Tumors and Lung Cancer
Status: COMPLETED
Conditions: Carcinoma|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Karenitecin (BNP1350)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MargheRITA (Remote Intelligence for Therapeutic Adherence)
Status: COMPLETED
Conditions: Multiple Myeloma|Solitary Plasmacytoma|Amyloidosis|Chronic Myeloid Leukemia|Chronic Lymphocytic Leukemia|T Cell Non-Hodgkin Lymphoma|Lymphocytic Lymphoma|Hodgkin Lymphoma|B-cell Non Hodgkin Lymphoma|Acute Myeloid Leukemia|Myelodysplasia|Chronic Myeloproliferative Disorder|Treatment Adherence|Treatment Adherence and Compliance
Interventions: DEVICE: RITA (App)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Blood Flow Restriction And Veterans With MS
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: OTHER: Low-Load Exercise with Blood Flow Restriction|OTHER: Low-Load Exercise Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Airway Injuries After Intubation Using Videolaryngoscopy Versus Direct Laryngoscopy for Adult Patients Requiring Tracheal Intubation
Status: COMPLETED
Conditions: Airway Trauma|Airway Complication of Anesthesia
Interventions: DEVICE: Video laryngoscopy|DEVICE: Direct laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin
Status: COMPLETED
Conditions: Spinal Cord Diseases|Spinal Cord Injuries
Interventions: DEVICE: long-term paired associative stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Association Between the Duration of Acute Kidney Injury and New-onset Chronic Kidney Disease After Cardiac or Thoracic Aortic Surgery
Status: COMPLETED
Conditions: Acute Kidney Injury|Chronic Kidney Disease, Stage 3|Chronic Kidney Disease, Stage 5|Cardiac Surgery|Thoracic Aortic Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess Indices of SNAP vs VISTA on Surgical Patients Undergoing General Anesthesia
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: DEVICE: SNAP monitor; Bispectral Index Monitor (BIS Monitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Game-Based Learning and Telesimulation on Nursing Students' Management of Postpartum Hemorrhage
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: OTHER: Telesimulation|OTHER: Kahoot Game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Investigation of Oxidative Stress in West Nile Virus Infection
Status: WITHDRAWN
Conditions: West Nile Virus|West Nile Fever|West Nile Fever Encephalitis|West Nile Fever Meningitis|West Nile Meningitis|West Nile Virus Meningoencephalitis|West Nile Fever Meningoencephalitis|West Nile Fever With Neurologic Manifestation|Oxidative Stress
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: recombinant interferon alfa|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: etoposide|DRUG: melphalan|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Full Face Mask for the Treatment of Obstructive Sleep Apnea (OSA) in NZ
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: F&P Jupiter Full Face Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Oral Nicotine|DRUG: NiQuitinTM Nicotine Lozenge|DRUG: Nicorette® Nicotine Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension
Status: RECRUITING
Conditions: Tourniquet Hypertension|Intraoperative Hypertension|Total Ankle Arthroplasty|Ankle Fusion
Interventions: DRUG: Mepivacaine|DRUG: Saline|PROCEDURE: Perifemoral Injection of Local Anesthetic|PROCEDURE: Perifemoral Injection of Local Anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase Ⅱ Study Assessing the Safety and Efficacy of PLB1004 in EGFR ex20ins Mutation Patients With Advanced and Metastatic Non-small Cell Lung Cancer(NSCLC)
Status: RECRUITING
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: PLB1004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Forteo Trial on Idiopathic Osteoporosis in Premenopausal Women
Status: COMPLETED
Conditions: Adult Idiopathic Generalized Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of TJ011133 as Monotherapy and in Combination With Azacitidine (AZA) in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndromes(MDS)
Interventions: DRUG: TJ011133
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics Attenuate Postoperative Cognition Decline
Status: UNKNOWN
Conditions: Necrosis of Femoral Head|Knee Osteoarthritis|Fracture of Neck of Femur|Lumbar Disc Herniation
Interventions: DRUG: Bifidobacterium triple live capsule|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis
Status: RECRUITING
Conditions: Tuberculous Pericarditis|HIV Status
Interventions: DRUG: high dose Rifampicin (RIF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Coronary Flow Reserve by Doppler Flow WIre in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Differences Between the Loading Dose of Prasugrel and Ticagrelor .
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Non ST Elevation Myocardial Infarction|ST Elevation Myocardial Infarction|Unstable Angina
Interventions: PROCEDURE: Assessment of coronary flow reserve|PROCEDURE: Percutaneous Coronary Intervention|DRUG: Ticagrelor loading|DRUG: Prasugrel loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)
Status: COMPLETED
Conditions: Critically Ill|Hemodialysis
Interventions: DRUG: Daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Hyperbaric Oxygen Treatment for Veterans with Traumatic Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury|Military Operations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Hydromorphone for Pain Control After Cesarean Section
Status: COMPLETED
Conditions: Pain|Cesarean Section
Interventions: DRUG: Intrathecal morphine|DRUG: Intrathecal hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Consumer Engagement to Increase Advance Care Planning: Patient Randomization
Status: COMPLETED
Conditions: Advance Care Planning
Interventions: BEHAVIORAL: Financial incentive|BEHAVIORAL: Educational website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: simvastatin|DRUG: ezetimibe/simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gastric Partitioning Procedure for the Treatment of Unresectable and Obstructive Distal Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: Gastro-entero anastomosis only|PROCEDURE: Gastric partitioning Plus Gastro-entero anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of an Alphavirus Replicon Vaccine for Cytomegalovirus (CMV)
Status: COMPLETED
Conditions: Cytomegalovirus Infections
Interventions: BIOLOGICAL: AVX601|BIOLOGICAL: Placebo|BIOLOGICAL: AVX601|BIOLOGICAL: Placebo|BIOLOGICAL: AVX601|BIOLOGICAL: AVX601|BIOLOGICAL: AVX601|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
Status: COMPLETED
Conditions: Opiate Dependence|Chronic Pain
Interventions: BEHAVIORAL: CBT|DRUG: Buprenorphine|OTHER: Educational Counseling|OTHER: Physician Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Follow-up Study to Evaluate the Safety of ALLO-ASC-DFU in ALLO-ASC-DFU-301 Clinical Trial
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: BIOLOGICAL: ALLO-ASC-DFU|PROCEDURE: Vehicle sheet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between MR Arthrography ,ct Arthrography and Conventional MR in Osteoachondral Lesions of Knee Osteo Arthritis
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery
Status: RECRUITING
Conditions: Venous Thromboembolism|Pulmonary Embolism|Deep Vein Thrombosis|Cancer|Surgery
Interventions: BEHAVIORAL: Exposure to clinical decision support system and education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Enzymes on Dental Biofilm Accumulation in Healthy Individuals
Status: TERMINATED
Conditions: Dental Plaque
Interventions: OTHER: Enzyme lozenge 1|OTHER: Enzyme lozenge 2|OTHER: Placebo lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of a Progestin to Prevent Bleeding Associated With Initiation of Medical Menopause With GnRH Agonist
Status: TERMINATED
Conditions: Dysfunctional Uterine Bleeding
Interventions: DRUG: Medroxyprogesterone 17-Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Methods of Bilateral Stenting for Malignant Hilar Obstruction
Status: WITHDRAWN
Conditions: Bile Duct Neoplasm|Obstructive Jaundice
Interventions: PROCEDURE: parallel stent|DEVICE: Y-stent (BONASTENT M-Hilar)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Risk Adapted SABR(SABR) in Stage I NSCLC And Lung Metastases
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Neoplasm Metastasis
Interventions: RADIATION: 34 Gy in a single fraction|RADIATION: 54Gy 18Gy/fr. x 3 fractions|RADIATION: 60Gy (12 x 5 fr.s)|RADIATION: 60Gy (7.5Gy x 8fr.)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of SHR0410 Injection for the Treatment of Pain After Endoscopic Surgery of the Lower Abdominal
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: SHR0410 Injection|DRUG: Placebo|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Elafibranor in Adults With Primary Biliary Cholangitis and Inadequate Response or Intolerance to Ursodeoxycholic Acid.
Status: RECRUITING
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: Elafibranor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Impulsive Aggression (IA) in Adolescent With ADHD in Conjunction With Standard ADHD Treatment
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: SPN-810|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Perioperative Immunotherapy in MSI-H Gastrointestinal Tumors
Status: UNKNOWN
Conditions: To Evaluate the Safety and Effectiveness of Immunotherapy During the Perioperative Treatment Stage in MSI-H Gastrointestinal Cancer
Interventions: OTHER: No interventions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimetrexate glucuronate|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT