pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease
Status: COMPLETED
Conditions: Moderate to Severe Dry Eye Syndrome
Interventions: DRUG: nonsteroid anti-inflammatory drops|DRUG: nonsteroid anti-inflammatory drops|DRUG: corticosteroids|DRUG: artificial tear substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychiatric Neurosurgery (PNS) for Obsessive Compulsive Disorder (OCD): A Qualitative Analysis of Patient and Family Member Experiences
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: deep brain stimulation|PROCEDURE: anterior capsulotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Eribulin Mesylate in Combination With PEGylated Recombinant Human Hyaluronidase (PEGPH20) Versus Eribulin Mesylate Alone in Subjects With Human Epidermal Growth Factor Receptor 2 (HER2)-Negative, High-Hyaluronan (HA) Metastatic Breast Cancer (MBC)
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Eribulin mesylate|DRUG: Eribulin mesylate|DRUG: Eribulin mesylate|OTHER: Biologic: PEGylated recombinant human hyaluronidase (PEGPH20)|OTHER: Biologic: PEGylated recombinant human hyaluronidase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multiple-Dose Study of BLU-5937 in Chronic Pruritus Associated With Atopic Dermatitis
Status: COMPLETED
Conditions: Chronic Pruritus|Atopic Dermatitis
Interventions: DRUG: BLU-5937|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of INX-08189, Pharmacokinetic and Pharmacodynamic With Ribavirin and Food Effect Study, in Chronically-infected Genotype 1 Hepatitis C Virus, Treatment-naïve Subjects
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: 200 mg INX-08189 Fasted|DRUG: Placebo QD Fasted|DRUG: 100 mg INX-08189 QD|DRUG: Placebo QD|DRUG: 100 mg INX-08189 with low-fat meal|DRUG: Placebo with low-fat meal|DRUG: 100 mg INX-08189 BID Fasted|DRUG: Placebo BID Fasted|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Free Gingival Graft Adjunct With Low Level Laser Therapy
Status: COMPLETED
Conditions: Wounds and Injuries|Transplants|Gingival Recession, Localized|Low-Level Light Therapy
Interventions: DEVICE: CheseeTM Diode Laser|OTHER: Clinical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of SU011248 in Subjects With High Risk Prostate Cancer Who Have Elected to Undergo Radical Prostatectomy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: SU011248|DRUG: SU011248|DRUG: SU011248|DRUG: SU011248|DRUG: SU011248
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanism of Mindfulness Based Online Intervention in Reducing Emotional Distress: Daily Dairy Research
Status: NOT_YET_RECRUITING
Conditions: Emotional Distress
Interventions: BEHAVIORAL: Mindfulness Intervention for Emotional Distress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor|Hormone-receptor-positive Breast Cancer|Breast Cancer|Metastatic Breast Cancer|Hormone Receptor Positive Malignant Neoplasm of Breast|HER2-negative Breast Cancer
Interventions: DRUG: BGB-43395|DRUG: Fulvestrant|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples
Status: COMPLETED
Conditions: Chlamydia Trachomatis Infection|Neisseria Gonorrheae Infection|Mycoplasma Genitalium Infection|Sensitivity|Polymerase Chain Reaction
Interventions: DIAGNOSTIC_TEST: Two samples on each of the three sites (pharynx, rectum, urine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: Brain Metastases
Interventions: DIAGNOSTIC_TEST: 18F-Fluciclovine (Axumin)|DIAGNOSTIC_TEST: Pet Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Genes in Predicting Outcome in Patients With Esophageal Cancer Treated With Cisplatin, Radiation Therapy, and Surgery
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: GENETIC: loss of heterozygosity analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Vedolizumab SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: General Anesthesia Emergence Induced by Methylphenidate
Status: COMPLETED
Conditions: Delayed Emergence From Anesthesia
Interventions: DRUG: Methylphenidate HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Nebivolol to Evaluate Its Vasodilatory Effects in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol|DRUG: Metoprolol ER (TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Sufentanil for Analgesia of Severe Sickle Cell Vaso-occlusive Pain Crisis in the Pediatric
Status: NOT_YET_RECRUITING
Conditions: Vaso-occlusive Crisis
Interventions: DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Physical Exercise on Postmenopausal Risk Factors in Women With Osteopenia
Status: COMPLETED
Conditions: Osteopenia, Osteoporosis
Interventions: OTHER: High Intensity Resistance (HIT-RT) and Endurance exercise (HIIT)|OTHER: Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Teriparatide on Bone Union in Unstable Intertrochanteric Fracture Patients Treated With PFNA
Status: UNKNOWN
Conditions: Unstable Intertrochanteric Fracture
Interventions: DRUG: Teriparatide|DRUG: Placebo|DIETARY_SUPPLEMENT: Calcium supplement|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing
Status: COMPLETED
Conditions: Wound Healing|Lower Extremity Amputation|Above Knee Amputation|Below Knee Amputation
Interventions: PROCEDURE: Lower Extremity Amputation|DEVICE: SPY Elite Imaging System|DRUG: Indocyaine Green
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Vitamin D Supplements on Vitamin D Status, Cardiometabolic Health and Immune Defense in Danish Children
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device
Status: TERMINATED
Conditions: Low Back Pain|Spondylolisthesis|Spinal Stenosis|Intervertebral Disc Displacement
Interventions: DEVICE: Lumbar Interbody Fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Episcleral Brachytherapy for the Treatment of Wet AMD
Status: ACTIVE_NOT_RECRUITING
Conditions: Macular Degeneration, Choroidal Neovascularization
Interventions: RADIATION: episcleral brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Cell Damage in Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, or Fanconi Anemia; in Patients Who Were Exposed to Alkylating Agents; and in Healthy Volunteers
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: GENETIC: cytogenetic analysis|GENETIC: fluorescence in situ hybridization|OTHER: flow cytometry|PROCEDURE: biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients
Status: NOT_YET_RECRUITING
Conditions: Emergency Psychiatric|Cognition Disorder|Movement Disorders|Antipsychotics and Neuroleptics Toxicity|Dementia With Lewy Bodies|Alteration in Mental Status|Behavior|Aging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: First-time-in-Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Placebo|DRUG: GSK3358699|BIOLOGICAL: GM-CSF|BIOLOGICAL: LPS|OTHER: Cantharidin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns
Status: COMPLETED
Conditions: Neonatal Sepsis|Omphalitis
Interventions: DRUG: Chlorhexidine Topical Cream|DRUG: Methylated Spirit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate Use of Elidel® in South and East Asian Pediatric Patients With Atopic Dermatitis.
Status: NOT_YET_RECRUITING
Conditions: Mild to Moderate Atopic Dermatitis
Interventions: DRUG: Elidel 1% Topical Cream
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Controlled Trial of a Digital, Self-testing Strategy for COVID-19 Infection in South Africa.
Status: RECRUITING
Conditions: COVID-19
Interventions: DEVICE: Abbott Panbio rapid antigen self-tests|OTHER: COVIDSmart CARE! app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Class II Restorations With High-Filled Flowable Composites
Status: NOT_YET_RECRUITING
Conditions: Dental Caries|Class II Dental Caries
Interventions: OTHER: High-filling flowable dental composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Laryngeal Morbidity After Orotracheal Intubation by Vocal Analysis and Laryngostroboscopy
Status: COMPLETED
Conditions: Intubation Complication|Vocal Cord Dysfunction|Vocal Tone Disorder|Intubation;Difficult
Interventions: DIAGNOSTIC_TEST: Vocal analysis and Laryngostroboscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study of Fish Oil Supplementation in Hemodialysis Patients
Status: COMPLETED
Conditions: End-Stage Renal Disease Patients on Hemodialysis
Interventions: DRUG: Fish oil capsules|DRUG: matched placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Youth and Adult Microfinance to Improve Resilience Outcomes in Democratic Republic of Congo
Status: COMPLETED
Conditions: Mental Health Disorders
Interventions: BEHAVIORAL: adult microfinance|BEHAVIORAL: Youth microfinance only|BEHAVIORAL: youth and adult micro finance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing Number of Injection Sites of In-office Intravesical Onabotulinumtoxin A Treatments for Overactive Bladder: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Overactive Bladder Syndrome|Overactive Bladder
Interventions: DRUG: OnabotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PTSD Mobile App for Cancer Survivors
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder|Cancer
Interventions: BEHAVIORAL: Cancer Distress Coach (CaDC) App|BEHAVIORAL: CaDC + mCoaching|BEHAVIORAL: mCBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Development of Read-outs in Healthy, Hepatitis B Virus Naive Adults Vaccinated With the Hepatitis B Surface Antigen (HBsAg) in Combination With a GlaxoSmithKline (GSK) Biologicals' Adjuvant System
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Adjuvanted Hepatitis B surface antigen (HBsAg) candidate vaccine GSK2231392A.|BIOLOGICAL: EngerixTM-B|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Randomized Salvage Radiation Therapy Plus Enzalutamide Post Prostatectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Prostate
Interventions: DRUG: Enzalutamide|RADIATION: SRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Weekly Abraxane and RAD001 in Women With Locally Adv. or Metastatic Breast Ca
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: everolimus|DRUG: abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Bevacizumab for the Management of Recurrent Epistaxis in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
Status: COMPLETED
Conditions: Hereditary Hemorrhagic Telangiectasia (HHT)
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LN-145, Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Cervical Carcinoma
Status: RECRUITING
Conditions: Cervical Carcinoma
Interventions: BIOLOGICAL: LN-145|BIOLOGICAL: LN-145 + pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Cognition Disorder|Nervous System Diseases|Mental Disorders|Brain Diseases
Interventions: DRUG: galantamine hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK Study in Subjects With Renal Impairment (Severe and if Required Mild & Moderate) Compared to Subjects With Normal Renal Function
Status: COMPLETED
Conditions: Renal Impairment|Normal Renal Function
Interventions: DRUG: MT-7117
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Safety and Efficacy of TOCOSOL(R) Paclitaxel Versus Taxol(R) for Treatment of Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasm
Interventions: DRUG: Taxol|DRUG: TOCOSOL Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of E10A in Head and Neck Cancer
Status: UNKNOWN
Conditions: Head and Neck Squamous Carcinoma|Nasopharyngeal Carcinoma
Interventions: DRUG: E10A|DRUG: Cisplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LY3214996 Plus Abemaciclib in Recurrent Glioblastoma Patients
Status: RECRUITING
Conditions: Glioblastoma|GBM|Glioma
Interventions: DRUG: Abemaciclib|DRUG: LY3214996
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orthopedic Study of the Aircast StabilAir Wrist Fracture Brace
Status: TERMINATED
Conditions: Radius Fractures
Interventions: DEVICE: StabilAir Wrist Brace|OTHER: Placement of sugar tong splint or plaster cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty
Status: ACTIVE_NOT_RECRUITING
Conditions: Frailty|Surgery--Complications|Disability Physical
Interventions: BEHAVIORAL: Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rhabdomyosarcoma and Malignant Soft Tissue Tumours of Childhood
Status: TERMINATED
Conditions: Rhabdomyosarcoma|Malignant Soft Tissue
Interventions: DRUG: Ifosfamide, oncovin, actinomycine D, epirubicine, carboplatinum, etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Bevacizumab Alone or Combined With Capecitabine and Oxaliplatin as Support Therapy in Metastatic Colorectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: XELOXA|DRUG: XELOXA-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dual-scopic Pancreatic Necrosectomy (DPN)
Status: RECRUITING
Conditions: Pancreatitis|Pancreatitis, Acute Necrotizing|Pancreatic Diseases
Interventions: PROCEDURE: Dual-scopic pancreatic necrosectomy（DPN）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research on Nicorandil Treatment of Patients Diagnosed as CHD (Coronary Heart Disease) With Stable Angina
Status: COMPLETED
Conditions: Stable Angina|Coronary Disease
Interventions: DRUG: Nicorandil|DRUG: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MONITOR Study: Remote Monitoring Of a Nutrition Intervention To Optimize Treatment Response
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: BEHAVIORAL: Quality fo Life Questionnaire (FHSI)|BEHAVIORAL: Vioscreen Food Frequency Questionnaire (FFQ)|BEHAVIORAL: Educational Handouts|BEHAVIORAL: NutritionCoaching|BEHAVIORAL: Follow-Up Survey|BEHAVIORAL: Functional Assessment of Anorexia/Cachexia Treatment (FAACT) Questionnaire|BEHAVIORAL: Patient Reported Outcomes Measure- Cognitive Function (PROMIS-Cog) Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radicle GI Health 24: A Study of Health and Wellness Products on GI Health and Related Health Outcomes
Status: RECRUITING
Conditions: Abdominal Pain|GI Disorders|Digestion
Interventions: DIETARY_SUPPLEMENT: Radicle GI Health Placebo Control Form 1|DIETARY_SUPPLEMENT: Radicle GI Health Active Study Product 1.1 Usage|DIETARY_SUPPLEMENT: Radicle GI Health Placebo Control Form 2|DIETARY_SUPPLEMENT: Radicle GI Health Active Study Product 2.1 Usage|DIETARY_SUPPLEMENT: Radicle GI Health Placebo Control Form 3|DIETARY_SUPPLEMENT: Radicle GI Health Active Study Product 3.1 Usage|DIETARY_SUPPLEMENT: Radicle GI Health Placebo Control Form 4|DIETARY_SUPPLEMENT: Radicle GI Health Active Study Product 4.1 Usage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Treatment Effects on Neuromuscular Properties on Young Women Symptomatic for Patellofemoral Pain Syndrome
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Model 1|OTHER: Model 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: doxycycline (tetracycline)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pneumovitreolysis for Vitreomacular Traction
Status: UNKNOWN
Conditions: Vitreomacular Traction Syndrome
Interventions: PROCEDURE: Pneumatic Vitreolysis in combination with "Drinking-Bird-Technique"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment and Treatment of Caffeine Dependence
Status: COMPLETED
Conditions: Self-identified Problematic Caffeine Use|DSM-IV Substance Dependence as Applied to Caffeine
Interventions: BEHAVIORAL: Individualized caffeine cessation instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Inspiratory Muscle Training on Respiratory Parameters and Functional Capacity in Idiopathic Scoliosis
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis
Interventions: OTHER: Home based exercise program|OTHER: Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Habitual Wearers of Bioclear 1-day Lenses When Refitted With Biomedics 1-day Extra for 1 Week
Status: COMPLETED
Conditions: Myopia|Hyperopia
Interventions: DEVICE: filcon IV 1|DEVICE: ocufilcon D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Determine the Effectiveness of Antiviral Combination Therapy to Treat Hepatitis C Virus (HCV) Infected Patients Who Have Previously Failed Standard of Care
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: BMS-790052|DRUG: BMS-650032|DRUG: BMS-650032|DRUG: BMS-650032|DRUG: Pegylated-interferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Rollover Safety Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Years and Older With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: LUM/IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between Heat Pain Detection Threshold and Area of Secondary Hyperalgesia
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Brief thermal sensitization|OTHER: Pain during 1 min. thermal stimulation|OTHER: Heat pain detection threshold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of ACZ885 in Adult Patients With Established Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ACZ885 (investigational)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Coadministration of FOV1101-00 and Prednisolone Acetate in Patients With Mild Ongoing Ocular Allergic Inflammation
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Prednisolone Acetate 0.12% (Pred Mild®)|DRUG: FOV1101-00|DRUG: Prednisolone Acetate 1% (Pred Forte®)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Volunteers, Absorption, Distribution, Metabolism and Excretion (ADME) Study With Single Oral Administration of [14C] AZD8931
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [14C] AZD8931
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Water and Food Intake on the Pharmacokinetics and Pharmacodynamics of Oral Salmon Calcitonin in Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: Oral salmon calcitonin, salmon calcitonin nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Superoxide Dismutase (SOD) as Antioxidant Treatment OF Age Related Macular Degeneration (ARMD)
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DIETARY_SUPPLEMENT: SOD|DIETARY_SUPPLEMENT: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SH-DS01 on Fecal Metagenomic Stability
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: DS-01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Nutritional Supplement vs Conventional Dietary Advice in Major Gastrointestinal Surgery
Status: UNKNOWN
Conditions: Surgery--Complications|Nutrition Aspect of Cancer
Interventions: DIETARY_SUPPLEMENT: Oral nutritional supplement (ONS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for Patients With Hypertension Associated With Dyslipidemia
Status: COMPLETED
Conditions: Hypertension|Dyslipidemia
Interventions: DRUG: DWJ1276|DRUG: Olmesartan|DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Candidate Tuberculosis (TB) Vaccine Given to PPD-Negative Adults
Status: COMPLETED
Conditions: Tuberculosis (TB)
Interventions: BIOLOGICAL: GSK's candidate Mycobacterium tuberculosis vaccine 692342
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mazor X Stealth Versus O-arm Navigation for Pedicle Screw Insertion
Status: UNKNOWN
Conditions: Disorder of Spine
Interventions: DEVICE: Guidance for pedicle screw insertion (Mazor Stealth)|DEVICE: Guidance for pedicle screw insertion (O-arm Navigation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Emtricitabine/tenofovir|DRUG: Colchicine Pill|DRUG: Rosuvastatin|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: Vaccinia virus: ACAM2000 smallpox vaccine|BIOLOGICAL: vaccinia virus (calf lymph): Dryvax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of the Effect of Central Sensitization (CS) on Steroid Injection Response in Rotator Cuff Lesion
Status: RECRUITING
Conditions: Central Sensitisation|Subacromial Impingement Syndrome
Interventions: DRUG: Injection of 1 CC Betamethasone Dipropionate + Betamethasone Sodium Phosphate (Diprospan) and 4 cc 2% Prilocaine (Priloc)mixture into the subacromial space
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial
Status: COMPLETED
Conditions: Diabetes|Endocrine System Diseases|Gastro-Intestinal Disorder|Neuro-Degenerative Disease|Epilepsy|Autoimmune Diseases|Renal Disease|Cardiac Disease|Metabolic Disease|Genetic Diseases, Inborn|Respiratory Disease|Hematologic Diseases|Autism Spectrum Disorder|Fetal Alcohol Spectrum Disorders|Traumatic Brain Injury|Stroke
Interventions: OTHER: Patient Navigator|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MIS-D Versus MIS-TLIF for the Treatment of Lumbar Spinal Stenosis
Status: NOT_YET_RECRUITING
Conditions: Spinal Stenosis
Interventions: PROCEDURE: minimally invasive spinal decompression (MIS-D)|PROCEDURE: minimally invasive spinal decompression and fusion (MIS-TLIF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Antidepressant Efficacy of a Selective, High Affinity Enkephalinergic Agonist in Anxious Major Depressive Disorder (AMDD)
Status: COMPLETED
Conditions: Anxious Major Depressive Disorder
Interventions: DRUG: AZD2327|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Estradiol Plus Olaparib for Breast Cancer (PHOEBE)
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Olaparib|DRUG: 17b-estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Colon Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: carboplatin|DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Thromboembolic Complications After Pacemaker or Implantable Cardioverter-Defibrillator Procedures
Status: UNKNOWN
Conditions: Bradyarrhythmias|Arrhythmias|Cardiovascular Disease|Venous Thrombosis|Pulmonary Embolism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chiropractic Care and a Specific Regimen of Nutritional Supplementation for Patients With Acute Ankle Sprain
Status: TERMINATED
Conditions: Ankle Sprains
Interventions: DIETARY_SUPPLEMENT: Dietary supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LCB01-0371|DRUG: Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Approaches for Dacryocystorhinostomy Surgery: The Effect of Adding Local Anesthesia to General Inhalational Anesthesia
Status: RECRUITING
Conditions: Effects of; Anesthesia, Local,Pain,in DISE
Interventions: PROCEDURE: Combination of General anesthesia and local anesthesia in dacryocystorhinostomy surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of RC48-ADC for the Treatment of Locally Advanced or Metastatic Breast Cancer With Low Expression of HER2
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: RC48-ADC|DRUG: Paclitaxel Injection|DRUG: Docetaxel Injection|DRUG: Vinorelbine Tartrate Injection|DRUG: Capecitabine Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Influenza Vaccination in U.S. Nursing Homes
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza|Influenza -Like Illness|Influenza, Human
Interventions: BIOLOGICAL: Recombinant Influenza Vaccine|BIOLOGICAL: Standard Dose Quadrivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Capmatinib in Chinese Adult Patients With Advanced Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Capmatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab(Henlius®) Combined With Pertuzumab(Perjeta®) and Chemotherapy in Chinese Patients With Her2-Positive Metastatic Breast Cancer Previously Treated With Trastuzumab
Status: UNKNOWN
Conditions: HER2-positive Metastatic Breast Cancer|Previously Treated With Trastuzumab|Trastuzumab Combined With Pertuzumab and Chemotherapy
Interventions: DRUG: trastuzumab(Henlius®) combined with Pertuzumab(Perjeta®) and Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of COVID-19 Outpatient Treatment in Individuals With Risk Factors for Aggravation
Status: COMPLETED
Conditions: Corona Virus Infection|Sars-CoV2
Interventions: DIETARY_SUPPLEMENT: Vitamins|DRUG: Telmisartan|DRUG: Ciclesonide|DRUG: interferon β-1b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Requirements of Propofol With Target Controlled Infusions for Supraglottic Airway Devices
Status: COMPLETED
Conditions: Appropriate Affect|Complication of Device Insertion
Interventions: DRUG: Propofol Fresenius
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab Plus Carboplatin-gemcitabine in Urothelial Carcinoma
Status: COMPLETED
Conditions: Metastatic Urothelial Cancer
Interventions: COMBINATION_PRODUCT: avelumab 10mg/kg with carboplatin/gemcitabine|COMBINATION_PRODUCT: carboplatin/gemcitabine alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III: Assess Conventional RT w/ Conventional Plus Accelerated Boost RT in the Treatment of Nasopharyngeal CA
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation the Safety and Efficacy of KL003 Cell Injection in the Treatment of Transfusion-dependent β-thalassemia.
Status: ACTIVE_NOT_RECRUITING
Conditions: Transfusion-dependent Beta-Thalassemia
Interventions: GENETIC: KL003 cell injection Drug Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of SPARC001 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SPARC001A|DRUG: SPARC001B|DRUG: Reference001 - Hydrocodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Lignan-rich Diet on Cardiometabolic Risk Factors
Status: COMPLETED
Conditions: Metabolic Syndrome|Overweight|Central Obesity|Impaired Glucose Tolerance
Interventions: OTHER: Whole-grain rye, high lignan|OTHER: Whole-grain wheat, low lignan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Looking at the Effectiveness, Immune Response, and Safety of a COVID-19 Vaccine in Adults in the United Kingdom
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 rS/Matrix M1-Adjuvant|OTHER: Placebo|BIOLOGICAL: Licensed seasonal influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US
Status: COMPLETED
Conditions: Dental Plaque|Gingivitis
Interventions: DRUG: Triclosan/fluoride toothpaste|DRUG: stannous fluoride toothpaste|DRUG: fluoride toothpaste|DRUG: Fluoride Mouthwash|DRUG: cetylpyridinium chloride Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas
Status: WITHDRAWN
Conditions: Soft Tissue Sarcomas
Interventions: DRUG: Chemoradiotherapy Temozolomide|RADIATION: Proton therapy|PROCEDURE: Proton Chemoradiotherapy followed by surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of the Answer to the Treatment by Biotherapies for Naive Spondyloarthritis by Combinatorial Analysis of Serum Biomarkers
Status: COMPLETED
Conditions: Spondylitis, Ankylosing
Interventions: DRUG: Etanercept ® 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effectiveness of Licorice Extract Dietary Supplement on the Treatment of Postmenopausal Symptoms
Status: UNKNOWN
Conditions: Postmenopausal Symptoms|Vaginal Dryness
Interventions: DIETARY_SUPPLEMENT: Calmera-Licorice Root Extract (Licogen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-Line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects With Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Status: RECRUITING
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: Tarlatamab|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Atezolizumab|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validity of PEEK PSI Containing Autogenous Bone Graft for Maxillary Reconstruction Following Lesion Enucleation
Status: UNKNOWN
Conditions: Maxillary Cyst
Interventions: DEVICE: Poly Ether Ether Ketone PSI (patient specific implant).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, PK and Efficacy of Single Doses of NV-5138 in Healthy Volunteers and Subjects With Treatment-Resistant Depression
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DRUG: NV-5138|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Efﬁcacy of Rebamipide Gargle And Benzydamine HCL Gargle in Prevention and Management of Chemo- and Radio-therapy-induced Oral Mucositis
Status: UNKNOWN
Conditions: Oral Mucositis
Interventions: DRUG: Ribamipide gargle \benzdymine HCL gargel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Novel Therapeutic Hepatitis B Virus Synthetic Long Peptide Vaccination ISA104
Status: RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: ISA104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality Improvement Project of Nurse Guiding Incentive Spirometry After Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Lung Expansion Therapy|Post-cardiac Surgery
Interventions: BEHAVIORAL: on-the-job training of lung expansion therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quality of Life and Autonomy in Health of Overweight or Obese People Receiving Reinforced Support
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Obese or overweight health subjects involved in the X-Ailes program (at least one contact with the health system navigator)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a Lopinavir/Ritonavir Monotherapy vs a Triple Therapy as Maintenance Regimens in HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: efavirenz/emtricitabin/tenofovir|DRUG: lopinavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management
Status: UNKNOWN
Conditions: Pain|Chronic Pain|Back Pain|Nociceptive Pain|Neuropathic Pain|Musculoskeletal Pain|Neck Pain|Pain, Intractable
Interventions: OTHER: Observational
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Recruitment Maneuver With Protective Ventilation During Thoracic Surgery
Status: COMPLETED
Conditions: Mechanical Ventilation Complication|Thoracic Surgery|Inflammation
Interventions: PROCEDURE: protective ventilation|PROCEDURE: Recruitment maneuver combined with protective ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Purple Sweet Potato (PSP)-Juice on Liver Enzymes and Blood Pressure
Status: COMPLETED
Conditions: Health|Blood Pressure|Liver Function|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: purple sweet potato (PSP)-juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Universal Use of EFV-TDF-FTC and AZT-3TC-LPV/r Combinations for HIV-1 PMTCT in Pregnant and Breastfeeding Women : a Phase 3 Trial
Status: WITHDRAWN
Conditions: HIV Infection|Pregnancy|Breastfeeding|HIV Infections
Interventions: DRUG: Efavirenz-Tenofovir-Emtricitabine|DRUG: Zidovudine-Lamivudine-Lopinavir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Building Community Health Volunteers' Capacity to Support Parents With Young Children With SafeCare Kenya
Status: RECRUITING
Conditions: Child Maltreatment|Parenting
Interventions: BEHAVIORAL: SafeCare Kenya|OTHER: Care as Usual by Community Health Volunteers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance
Status: COMPLETED
Conditions: Multiple Sclerosis|Mitochondrial Alteration
Interventions: DIAGNOSTIC_TEST: Oral glucose tolerance test|DIAGNOSTIC_TEST: Testing of autonomous nervous system function|DIAGNOSTIC_TEST: Stroop test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CSD190103: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products
Status: COMPLETED
Conditions: Tobacco Use
Interventions: OTHER: A19010-W|OTHER: B19010-F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER