pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy
Interventions: DRUG: Intravitreal bevacizumab|PROCEDURE: Small-gauge pars plana vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nail Versus Sliding Hip Screw for Trochanteric Hip Fractures
Status: COMPLETED
Conditions: Hip Injuries
Interventions: DEVICE: sliding hip screw|DEVICE: intramedullary nial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Persona Total Knee Arthroplasty System Using CR or MC Polyethylene
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: MC polyethylene bearing|DEVICE: CR polyethylene bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of the S'TIM Serious-Game for Rehabilitation of Dysexecutive Disorders (S'TIM)
Status: UNKNOWN
Conditions: Dysexecutive Syndrome|Serious Game
Interventions: DEVICE: Serious Game S'TIM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Supraglottic Jet Oxygenation and Ventilation for Gastrointestinal Endoscopy at High-altitude
Status: UNKNOWN
Conditions: Hypoxia|High Altitude
Interventions: PROCEDURE: Supraglottic jet oxygenation and ventilation|PROCEDURE: Nasal cannula oxygen supply
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Amoxicillin|DRUG: Benzyl penicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of VR for Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar Disorder|VR|Interventional Study
Interventions: DEVICE: VR therapy|DEVICE: VR sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-week Extension Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Brexpiprazole|DRUG: Brexpiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting the Risk of Failure in Patients Undergoing Radiation Therapy for Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|Radiation Toxicity
Interventions: OTHER: medical chart review|OTHER: questionnaire administration|PROCEDURE: quality-of-life assessment|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Mechanistic Exploratory Study of AF-induced Cardiac Dysfunction and Symptoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation|Heart Failure
Interventions: OTHER: Holter monitoring|OTHER: stress echocardiography|OTHER: Cardiac MRI|OTHER: Patient questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improve the Treatment of Thoracic Esophageal Cancer
Status: COMPLETED
Conditions: Thoracic Esophageal Squamous Cell Carcinoma
Interventions: DRUG: adjuvant chemotherapy|PROCEDURE: standard two field Lymphadenectomy|PROCEDURE: Total two field Lymphadenectomy|PROCEDURE: three field Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurologic Disorder|Paralysis|Paralysis; Stroke|Amyotrophic Lateral Sclerosis|Muscular Dystrophies|Spinal Cord Injuries|Stroke, Lacunar|Stroke Brainstem|Cervical Spinal Cord Injury|Spinal Muscular Atrophy|Tetraplegic; Paralysis|Quadriplegia/Tetraplegia
Interventions: DEVICE: Motor Neuroprosthesis (MNP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial
Status: RECRUITING
Conditions: Preeclampsia
Interventions: DRUG: 75 mg acetylsalicylic acid|DRUG: 1.5g Metformin|DRUG: 150 mg acetylsalicylic acid|DRUG: Placebo of acetylsalicylic acid and Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-Inflammatory Effects of Rosiglitazone in Patients With Stage 4 and 5 Chronic Kidney Disease
Status: WITHDRAWN
Conditions: Chronic Kidney Disease|Inflammation
Interventions: DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics (PK) of Alefacept in Adolescent Subjects With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: alefacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extensively Diseased Left Anterior Descending Coronary Artery: On Pump vs Off Pump CABG?
Status: UNKNOWN
Conditions: CAD - Coronary Artery Disease
Interventions: PROCEDURE: On-Pump CABG|PROCEDURE: Off-Pump CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: QBW251|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Methylnaltrexone (MNTX) on Electrocardiogram (ECG) Parameters and Cardiac Repolarization
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Methylnaltrexone (MNTX)|DRUG: Methylnaltrexone (MNTX)|DRUG: Methylnaltrexone (MNTX)|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Revascularization Strategies in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome (NSTE-ACS) and Severe Coronary Artery Disease
Status: NOT_YET_RECRUITING
Conditions: Multivessel Coronary Artery Disease|Acute Coronary Syndrome
Interventions: PROCEDURE: PCI|PROCEDURE: CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Routine Video-recording on Colonoscopy Quality Indicators.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Implementation of routine videorecording|BEHAVIORAL: No routine videorecording
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of Lenalidomide as Maintenance Therapy After Completion of First-line Combination Chemotherapy in Patients With Mantle Cell Lymphoma (MCL).
Status: TERMINATED
Conditions: Mantle Cell Lymphoma|Non-Hodgkin's Lymphoma
Interventions: DRUG: Lenalidomide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study of the "Easy Light" Fluorecence Imaging System
Status: COMPLETED
Conditions: Uterine Cervical Neoplasms|Uterine Neoplasms
Interventions: DEVICE: Sentinel Lymph Node Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Analgesic Efficacy After Pancreatobiliary Surgery: Intravenous Versus Patient-controlled Epidural
Status: UNKNOWN
Conditions: Pancreatic Cancer|Biliary Tract Neoplasms
Interventions: PROCEDURE: Patient-controlled analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Response to Beverages With Various Sweetening Systems Consumed During Meal in Overweight and Obese Subjects
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: Control product E|OTHER: Test product A|OTHER: Test product B|OTHER: Test product C|OTHER: Test product D|OTHER: Comparative product F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Study of BYL719 in Combination With Cisplatin and Radiotherapy in Patients With Squamous Cell Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of Head and Neck|Locoregionally Advanced
Interventions: DRUG: BYL719|DRUG: Cisplatin|RADIATION: Intensity modulated radiation therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Control Post Endovascular Treatment of Aortic Aneurisms Through Magnetic Resonance and Ultrasound (SAFEVAR)
Status: COMPLETED
Conditions: Abdominal Aortic Aneurism
Interventions: RADIATION: CT with contrast agent|DIAGNOSTIC_TEST: MR without contrast agent|DIAGNOSTIC_TEST: Color-Doppler Ultrasound|OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma
Status: RECRUITING
Conditions: Bone Sarcoma|Soft Tissue Sarcoma|Pulmonary Metastases
Interventions: DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Chemotherapy With Anthracycline Followed by Nab-paclitaxel and Trastuzumab
Status: COMPLETED
Conditions: Breast Cancer|HER-2 Positive Breast Cancer|Effects of Chemotherapy
Interventions: DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supporting Decision Making for Musculoskeletal Preference-Sensitive Care
Status: COMPLETED
Conditions: Knee Pain Chronic|Arthritis (Hip)|Arthritis (Knee)|Back Pain
Interventions: BEHAVIORAL: Provision of condition specific shared decision making (SDM) aids only|BEHAVIORAL: Telephonic outreach and support by Health Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Day Long Prevention of Oral Malodor With a Palatal Patch (SmellX) Containing A Herbal Formula
Status: COMPLETED
Conditions: Halitosis|Gingivitis
Interventions: DIETARY_SUPPLEMENT: herbal formula for fresh breath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Hippotherapy on Postural Asymmetries and Balance in Adolescents With Idiopathic Scoliosis
Status: COMPLETED
Conditions: Idiopathic Scoliosis|Equine-assisted Therapy
Interventions: OTHER: Hippotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine
Status: COMPLETED
Conditions: Nicotine Addiction|Panic Attack
Interventions: DRUG: d-cycloserine|DRUG: Pill Placebo|DRUG: Nicotine replacement therapy|BEHAVIORAL: Panic and Smoking Reduction Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dolutegravir Pediatric Liquid Formulation Study
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dolutegravir dispersible tablet|DRUG: Dolutegravir oral suspension|DRUG: Dolutegravir oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Equivalence Study of Mometasone Nasal Spray
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: placebo|DRUG: Mometasone Nasal Spray|DRUG: Mometasone nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of Naldemedine in Paediatric Participants Receiving Opioids
Status: RECRUITING
Conditions: Opioid-Induced Constipation (OIC)
Interventions: DRUG: Naldemedine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patient-ventilator Asynchrony During Mechanical Invasive Assisted-ventilation in Pediatric Patients
Status: UNKNOWN
Conditions: Respiration, Artificial
Interventions: OTHER: Pressure Support|DEVICE: NAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of [18F]Fluoroethyl Triazole Labelled [Tyr3]-Octreotate Analogues for the Imaging of Neuroendocrine Tumours.
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: [18F]-FET-βAG-TOCA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
Status: RECRUITING
Conditions: Renal Failure Acute|Multiple Organ Failure|Cardiovascular Diseases
Interventions: PROCEDURE: renal replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Efficacy, Safety, Tolerability and PK of ND0612H in Subjects With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: ND0612 (Levodopa/Carbidopa solution)|DRUG: ND0612 (Levodopa/Carbidopa solution) + morning oral IR-LD/CD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Kidney Disease, Chronic|Kidney Injury
Interventions: PROCEDURE: Roux-en-Y gastric bypass|DRUG: Best medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Relative Bioavailability of ASC18 Tablets vs Reference Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ASC18|DRUG: ravidasvir and sofosbuvir|DRUG: ASC18
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3 Adjuvated Reduced Dose IPV-Al SSI and Non-adjuvated Full Dose IPV SSI Given as Primary Vaccinations to Infants
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Primary series of immunisation comprised by 3 vaccinations IPV-Al SSI|BIOLOGICAL: IPV Vaccine SSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Integrated Radio Frequency Denervation System for the Treatment of Hypertension
Status: COMPLETED
Conditions: Hypertension|Metabolic Syndrome
Interventions: DEVICE: iRF System Renal Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effect of Dietary Fat Content on the Recurrence of Pancreatitis
Status: RECRUITING
Conditions: Acute Pancreatitis
Interventions: BEHAVIORAL: Dietary intervention: reduced fat diet|BEHAVIORAL: Dietary intervention: standard healthy diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: S-Metoprolol XR 25-50 mg Tablets vs Metoprolol Zok 50-100 mg Tablets in Hypertension Patients.
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Metoprolol|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing ARNI With ACE Inhibitor on Endothelial Function
Status: WITHDRAWN
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: sacubitril/valsartan|DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Acid Sphingomyelinase/Ceramide Pathway Activation in Radiotherapy Patients Using Intravoxel Incoherent Motion (IVIM) Diffusion-weighted Magnetic Resonance Imaging and Serum Biomarkers
Status: WITHDRAWN
Conditions: Metastatic Disease to Bone|Metastatic Disease to Soft Tissue
Interventions: DEVICE: MRI with IVIM DW-MRI|OTHER: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Elucidation and Monitoring Postprandial Endothelial Function
Status: COMPLETED
Conditions: Cardiovascular Disease|Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: high fat meal|DIETARY_SUPPLEMENT: control meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Evaluation of the Degradation of Renal Function Post Nephrectomy According to Retinal Vascularisation Parameters
Status: RECRUITING
Conditions: Nephrostomy|Retinal Vascularisation
Interventions: OTHER: retinal imaging|OTHER: paraclinical surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Zinc and Green Tea Extract for Community Respiratory Viral Infections
Status: TERMINATED
Conditions: Respiratory Viral Infection
Interventions: DRUG: zinc-green tea extract-ascorbic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of BDB-001 Injection in Patients With Moderate to Severe Hidradenitis Suppurativa (HS)
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: BDB-001 Injection|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Prolapse Surgery Accompanied by Mid Urethral Sling Versus no Sling for Reduction of Postoperative Incontinence
Status: UNKNOWN
Conditions: Stress Urinary Incontinence|Vaginal Hysterectomy|Quality of Life
Interventions: DEVICE: Retro pubic sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study Evaluating The Safety And Tolerability Of PF-04427429 In Healthy Adult Volunteers. The Pharmacokinetics And Pharmacodynamics Of PF-04427429 Will Also Be Investigated
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-04427429|BIOLOGICAL: PF-04427429
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combinatory ImmunoTherapy-1 (Com-IT-1) Irradiation and PD-1 Blockade in Locally Advanced / Advanced NSCLC
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Atezolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy
Status: COMPLETED
Conditions: Narcolepsy|Cataplexy|Excessive Daytime Sleepiness
Interventions: DRUG: AXS-12 (reboxetine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Treatment for Ebola Virus in Healthy Adults (V920-001)
Status: COMPLETED
Conditions: Ebola Virus
Interventions: BIOLOGICAL: V920|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: OTHER: Grass pollen sublingual immunotherapy tablet|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Topical Anti-adhesive Film for Decreasing Perihepatic Adhesions in Repeat Hepatic Surgery
Status: NOT_YET_RECRUITING
Conditions: Adhesion|Liver Neoplasms
Interventions: OTHER: Adhesion barrier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Six Hours Low Dose Gemcitabine Plus Cisplatin in the Treatment for Advanced Pleural Mesothelioma
Status: UNKNOWN
Conditions: Advanced Malignant Pleural Mesothelioma
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALK21-010: Long-term Safety of Medisorb® Naltrexone (VIVITROL®) in Alcohol-dependent Adults
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Medisorb naltrexone 380 mg|DRUG: Medisorb naltrexone 190 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Raltegravir Plus Maraviroc Therapy in Controlled HIV Patients Presenting With Lipohypertrophy
Status: TERMINATED
Conditions: Human Immunodeficiency Virus|Lipohypertrophy
Interventions: DRUG: Raltegravir-Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing Devices Used for Cardioversion of Atrial Fibrillation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Zoll external defibrillator|DEVICE: Lifepak external defibrillator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TreEat Study- Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants With Peanut Allergy
Status: ACTIVE_NOT_RECRUITING
Conditions: Food Allergy in Infants|Nut Allergy
Interventions: OTHER: Home introduction|OTHER: Multi Nut oral food challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Transplant Studies for Safe and Effective Treatment of Leukemia
Status: COMPLETED
Conditions: Graft vs Host Disease|Hematologic Neoplasm|Leukemia|Multiple Myeloma|Myelodysplastic Syndrome
Interventions: PROCEDURE: Allogeneic Bone Marrow Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Health Education Provided to Couples on Utilization of Maternity Waiting Homes in Rural Ethiopia
Status: RECRUITING
Conditions: Maternal Death|Maternal Behavior
Interventions: BEHAVIORAL: Behavioral intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)
Status: COMPLETED
Conditions: Infant,Premature
Interventions: PROCEDURE: Pulmonary Function Testing|PROCEDURE: Electrocardiogram|PROCEDURE: Positron Emission Tomography|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Measuring Lung Mechanics in Patients With COPD Using the REOM Handheld Portable Device
Status: RECRUITING
Conditions: Copd
Interventions: DEVICE: Rapid Expiratory Occlusion Monitor (REOM)|DIAGNOSTIC_TEST: Standard oscillometry|DIAGNOSTIC_TEST: Standard pulmonary function test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcatheter Mitral Valve Repair for the Treatment of Mitral Valve Regurgitation In Heart Failure (The EVOLVE-MR Trial)
Status: TERMINATED
Conditions: Ventricular Remodeling, Left
Interventions: DEVICE: MitraClip|DRUG: Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Medical Record Alerts to Optimize Medical Therapy in Heart Failure and Reduced Ejection Fraction
Status: NOT_YET_RECRUITING
Conditions: HFrEF - Heart Failure With Reduced Ejection Fraction
Interventions: OTHER: EMR alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MEDIPSA Clinical Trial
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DIETARY_SUPPLEMENT: Omnibiotic Stress Repair (OBSR)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Regimens Comparison for Breast Cancers of Positive Lymph Nodes
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Epirubicin, CTX, Paclitaxel|DRUG: Epirubicin, Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Analysis of Value of Contrast-enhanced Sonography During Biopsies of Focal Liver Masses
Status: TERMINATED
Conditions: Liver Biopsy
Interventions: DRUG: Lumason 60.7Mg Powder for Injection|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Forced-air Warming and Circulating-water Mattress in Preventing Heat Loss During Vascular Surgery
Status: COMPLETED
Conditions: Hypothermia|Vascular Surgery|Forced-air Warming Mattress|Circulating-water Mattress
Interventions: DEVICE: warming device (a reusable, custom-made forced- air warming mattress)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Intravenous Omega 3 Fatty Acids Administration in Elderly Patients Undergoing Hip Surgery
Status: COMPLETED
Conditions: Hip Surgery
Interventions: DIETARY_SUPPLEMENT: Omegaven-IV FO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Co-Administering Testosterone With PDE5 Inhibitors in ED Patients Non Responders to PDE5 Inhibitors Alone
Status: COMPLETED
Conditions: Erectile Dysfunction|Hypogonadism
Interventions: DRUG: Testosterone gel|DRUG: testosterone|OTHER: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analytical Treatment Interruption (ATI) to Assess the Immune System's Ability to Control HIV in Participants Who Became HIV-infected During the HVTN 703/HPTN 081 AMP Study
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infection
Interventions: OTHER: Analytical Treatment Interruption
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combined Non-ablative Er:YAG Laser and Magnetic Stimulation for Treatment of Female Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Urinary Incontinence
Interventions: DEVICE: non-ablative Er:YAG laser and high intensity Tesla magnetic stimulation (HITS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Partial Meal Replacement and Inulin in Obese Women
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Partial meal replacement|DIETARY_SUPPLEMENT: Partial meal replacement with inulin|DIETARY_SUPPLEMENT: Inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients at High Risk for Breast Cancer Recurrence
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: Globo-H-GM2-Lewis-y-MUC1-32(aa)-sTn(c)-TF(c)-Tn(c)-KLH conjugate vaccine|BIOLOGICAL: QS21
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arimidex With or Without Faslodex In Postmenopausal Women With HR Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Arimidex|DRUG: Faslodex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Dosing of BAY73-4506 in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Neoplasm
Interventions: DRUG: Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 20 mg|DRUG: Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 40 mg|DRUG: Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 100 mg|DRUG: Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 120 mg|DRUG: Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 140 mg|DRUG: HCC Child-Pugh A expansion cohort: Regorafenib 100 mg|DRUG: HCC Child-Pugh B expansion cohort: Regorafenib 100 mg|DRUG: NSCLC expansion cohort: Regorafenib 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Phytalgic in Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: phytalgic|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients With Advanced or Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Solid Tumor
Interventions: DRUG: PEP07
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Cervical Neoplasm|Endometrial Neoplasms
Interventions: RADIATION: Online adaptive radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Xiflam™ Treatment in Patients Post COVID-19 Infection Suffering From What is Known as Long COVID (LC)
Status: RECRUITING
Conditions: Long COVID
Interventions: DRUG: Tonabersat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of a New Trial Drug (FE200486) in Prostate Cancer Patients
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix|DRUG: Degarelix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regenerative Combined Therapy With Enamel Matrix Derivative and Biphasic Calcium Phosphate Graft
Status: COMPLETED
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: EMD|PROCEDURE: BC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Elobixibat (A3309) in Patients With Chronic Idiopathic Constipation
Status: COMPLETED
Conditions: Constipation|Chronic Constipation
Interventions: DRUG: A3309
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Bioavailability of Red Clover Isoflavones
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Fermented red clover isoflavones in aglycone form|DIETARY_SUPPLEMENT: Unfermented glycosides (as aglycone equivalents)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: FX006 32 mg|DRUG: TCA IR 40
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCLA Health Patient Cardiology Care Gaps
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Maintenance|Cardiology
Interventions: BEHAVIORAL: Monthly report card intervention|BEHAVIORAL: Storyboard intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Studies of the Early Meal Phase in Healthy Individuals - Nutrient Absorption and Gastrointestinal Hormone Secretion
Status: UNKNOWN
Conditions: Healthy
Interventions: OTHER: Oral glucose tolerance test|OTHER: Liquid mixed meal test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations
Status: TERMINATED
Conditions: Borderline Personality Disorder|BPD|Schizotypal Personality Disorder|SPD|Autism Spectrum Disorder|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder
Interventions: DRUG: Syntocinon 24 Intranasal Units (IU)|DRUG: Syntocinon 40 Intranasal Units (IU)|DRUG: Intranasal Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)
Status: NOT_YET_RECRUITING
Conditions: Acute Leukemia|Lymphoblastic Leukemia|Lymphoblastic Lymphoma
Interventions: DRUG: LP-118|DRUG: Ponatinib|DRUG: Vincristine|DRUG: Dexamethasone|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Stress Amongst Female Entrepreneurs in Addis Ababa, Ethiopia: a Pilot Study
Status: UNKNOWN
Conditions: Stress, Psychological|Emotion Regulation|Social Psychology|Economic Problems|Mental Stress
Interventions: BEHAVIORAL: Stress and emotion management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Post-marketing Study to Evaluate the Efficacy of Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Mass Zinc Fortification Programs on Plasma Zinc Concentration
Status: COMPLETED
Conditions: Zinc Deficiency
Interventions: DIETARY_SUPPLEMENT: Zinc-fortified bread|DIETARY_SUPPLEMENT: Zinc supplement|DIETARY_SUPPLEMENT: Non-fortified bread|DIETARY_SUPPLEMENT: Placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Photobiomodulation in the Treatment of Hand-foot Syndrome
Status: RECRUITING
Conditions: Erythrodysesthesia Syndrome
Interventions: DEVICE: Photobiomodulation|OTHER: Moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine To Control Post-Operative Pain Following BMG
Status: COMPLETED
Conditions: Urethral Stricture
Interventions: DRUG: Liposomal Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Bullous Pemphigoid With Avdoralimab (IPH5401), an Anti-C5aR1 Monoclonal Antibody
Status: COMPLETED
Conditions: Bullous Pemphigoid
Interventions: DRUG: Avdoralimab (IPH5401)|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compression Device Safety Study
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DEVICE: Placebo - No device worn|DEVICE: Prototype device(unnamed)-A battery operated inflatable pneumatic cuffs|DEVICE: Prototype device(unnamed)-A battery operated inflatable pneumatic cuffs|DEVICE: Prototype device(unnamed)-A battery operated inflatable pneumatic cuffs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection
Status: COMPLETED
Conditions: Opioid-Related Disorders|Neuralgia
Interventions: DRUG: Dexmedetomidine|DRUG: Lidocaine|OTHER: placebo|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Deep-brain Stimulation in Obsessive-compulsive Disorder: Randomized, Double-blinded Clinical Trial
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Deep Brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Data Collection Study for the Spectrum Dynamics Multi-purpose CZT SPECT Camera
Status: COMPLETED
Conditions: Dementia|Parkinson Disease|Pulmonary Hypertension|Heart Diseases|Paget Disease|Bone Diseases|Bone Fracture|Renal Disease|Pulmonary Embolism|Bone Lesion
Interventions: DEVICE: CZT SPECT imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Norketotifen for the Treatment of Uncomplicated Influenza-like Illness
Status: COMPLETED
Conditions: Influenza -Like Illness
Interventions: DRUG: Norketotifen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of NRTX-1001, a Cellular Therapy Product, for the Treatment of Refractory Bilateral TLE
Status: NOT_YET_RECRUITING
Conditions: Epilepsy, Temporal Lobe
Interventions: BIOLOGICAL: NRTX-1001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF PURSE-STRING CLOSURE VERSUS CONVENTIONAL PRIMARY CLOSURE FOLLOWING STOMA REVERSAL TO REDUCE SURGICAL SITE INFECTION RATE"
Status: UNKNOWN
Conditions: Surgical Site Infection|Difference in Surgical Site Infection According to Gender and Age Groups
Interventions: PROCEDURE: Purse string closure of Ileostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients
Status: RECRUITING
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: Foralumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Respiratory Muscle Training on Postoperative Pulmonary Complications of Cardiac Surgery
Status: COMPLETED
Conditions: Heart Diseases|Coronary Disease|Cardiovascular Diseases|Coronary Artery Occlusion
Interventions: OTHER: Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Subcutaneous Mircera for the Treatment of Anemia in Dialysis Patients.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: epoetin alfa or beta|DRUG: methoxy polyethylene glycol-epoetin beta (Mircera)|DRUG: methoxy polyethylene glycol-epoetin beta (Mircera)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy
Status: RECRUITING
Conditions: Solid Tumors|Lymphoma
Interventions: DRUG: Eflapegrastim|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PUSH Plus Protein Pilot for Hip Fracture Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hip Fracture
Interventions: BEHAVIORAL: PUSH|DIETARY_SUPPLEMENT: Protein|DIETARY_SUPPLEMENT: Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Tisagenlecleucel in Chinese Adult Patients With Relapsed or Refractory Diffuse Large B-cell Non-Hodgkin Lymphoma (DLBCL)
Status: WITHDRAWN
Conditions: Diffuse Large B-Cell Lymphoma (DLBCL)
Interventions: BIOLOGICAL: Tisagenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: End-of-Life Care for African Americans
Status: COMPLETED
Conditions: Colonic Neoplasms|Breast Neoplasms|Lung Neoplasms
Interventions: BEHAVIORAL: Educational DVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Substance P Antagonists on Adrenal Secretion
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: aprepitant/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Effect of "Mindfulness-Based Compassionate Life Training" for University Students Affected by the Earthquake
Status: NOT_YET_RECRUITING
Conditions: Earthquake|Trauma|Stress, Psychological
Interventions: OTHER: Session 1: How We Evolved - Threat, Impulse, and Soothing Systems|OTHER: Session 2: Threat and Self-Compassion|OTHER: Session 3: Unraveling the Knots of Desire and Patterns|OTHER: Session 4: Internalizing compassion|OTHER: Session 5: Me and others - Expanding the circle|OTHER: Session 6: Growing happiness|OTHER: Session 7: Weaving Wisdom and Compassion into Daily Life|OTHER: Session 8: Living with the Heart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ropivacaine Transversus Abdominis Plane Blocks for Cesarean Section Analgesia
Status: TERMINATED
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT