pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Antibiotic Prophylaxis in Laparoscopic Cholecystectomy
Status: TERMINATED
Conditions: Cholelithiasis
Interventions: DRUG: Ciprofloxacin|DRUG: Ampicillin-sulbactam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systems of Support (SOS) to Increase Colon Cancer Screening and Follow-up Supplement
Status: COMPLETED
Conditions: Colorectal Cancer Screening
Interventions: OTHER: 3 sample g-SENSA|OTHER: 2 sample InSure|OTHER: 1 sample OC-Micron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Ibuprofen 200 mg + Pseudoephedrine HCL 30 mg Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibuprofen + Pseudoephedrine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Toothbrushing Without Chlorhexidine on Oral Hygiene Indices in Patients With Orotracheal Intubation
Status: RECRUITING
Conditions: Oral Hygiene|Intensive Care|Chlorhexidine
Interventions: OTHER: Oral care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Adynamic Bone Disorder With Parathyroid Hormone in Chronic Kidney Disease
Status: RECRUITING
Conditions: Adynamic Bone Disease|Chronic Kidney Diseases|Cardiac Disease|Chronic Kidney Disease-Mineral and Bone Disorder
Interventions: DRUG: Teriparatide|DIAGNOSTIC_TEST: DXA,VFA, X-ray, HR-pQCT, 18-F NAF PET/CT|PROCEDURE: Bone biopsy|DIAGNOSTIC_TEST: Cardiac tests|OTHER: Blood and urine samples and physical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men
Status: SUSPENDED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Branched chain amino acid|BEHAVIORAL: Strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Oxycodone in Bariatric Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Oxycodone Hydrochloride|DRUG: Dezocine|DRUG: Esketamine and Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of EBV-TCR-T Cells for EBV-associated Hemophagocytic Lymphohistiocytosis or EBV Infection
Status: RECRUITING
Conditions: EBV-associated Hemophagocytic Lymphohistiocytosis|EBV Infection
Interventions: BIOLOGICAL: EBV-TCR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D for Critically Traumatic Patients
Status: RECRUITING
Conditions: Vitamin D Deficiency|Major Trauma
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scoring-Balloon Angioplasty and Sirolimus-Eluting Balloon Angioplasty for the Treatment of Diffuse, Small Vessel Coronary Artery Disease (SCA-DEB Study)
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Mozec™ SEB Sirolimus Eluting Rx PTCA Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mailed FIT Outreach 2022
Status: COMPLETED
Conditions: Colorectal Cancer|Colon Cancer
Interventions: BEHAVIORAL: Differentiated Box|BEHAVIORAL: Standard Mail|BEHAVIORAL: Text|BEHAVIORAL: No Text|BEHAVIORAL: Reminder|BEHAVIORAL: No Reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Dose Levels of Ad26.COV2.S Administered as a Two-dose Schedule in Healthy Adults
Status: COMPLETED
Conditions: COVID-19 Prevention
Interventions: BIOLOGICAL: Ad26.COV2.S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Vitamin B in Reducing Temporomandibular Joint Disorder Pain
Status: COMPLETED
Conditions: Temporomandibular Joint Disorder
Interventions: DRUG: Neurovit Forte|DRUG: Corn Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage Pupilloplasty
Status: RECRUITING
Conditions: Aphakia|Mydriasis
Interventions: PROCEDURE: Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage Pupilloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Lifestyle and Combination Medication Therapy Diabetes Prevention Study
Status: COMPLETED
Conditions: Impaired Glucose Tolerance|Diabetes
Interventions: DRUG: Avandamet [Rosiglitazone 2mg/Metformin 500mg] BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Astaxanthin Bioavailability, and a New Technology for Improving it, Using Natural Food Materials Only
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: AX-olive oil-PP emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of a Sintilimab Plus ICE Regimen Versus ICE Regimen in Classic Hodgkin's Lymphoma Patients (cHL) Who Have Failed First-line Standard Chemotherapy
Status: RECRUITING
Conditions: Classic Hodgkin's Lymphoma
Interventions: BIOLOGICAL: Sintilimab|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Placebo|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Oncological and Functional Outcomes After Robot Assisted Partial Nephrectomy Versus Laparoscopic Partial Nephrectomy
Status: COMPLETED
Conditions: Kidney Neoplasms
Interventions: PROCEDURE: Laparoscopic partial nephrectomy|PROCEDURE: Robot assisted partial nephrectomy|DEVICE: Conventional laparoscopic instruments|DEVICE: Da- Vinci Robot and conventional laparoscopic instruments|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Explore the Effect of Diet Intervention on Lipid Metabolism and Body Mass Index Among the Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: BEHAVIORAL: Intermittent fasting|BEHAVIORAL: Low carb diet|BEHAVIORAL: Low carbon diet and intermittent fasting group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Atorvastatin as a Renal Protection in Patients With Systemic Inflammatory Response Syndrome Using Renal Arterial Resistive Index
Status: RECRUITING
Conditions: Renal Protection
Interventions: DRUG: Atorvastatin 40 Mg Oral Tablet|DRUG: placebo drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Apatinib Combined With TACE in Advance Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Diet on Parents' Mental Health in the Postnatal Period
Status: COMPLETED
Conditions: Mood|Healthy|Mothers|Fathers|Parents
Interventions: DIETARY_SUPPLEMENT: Flavonoid-rich diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cambridge 7 Tesla Cerebral Small Vessel Disease Study
Status: UNKNOWN
Conditions: Cerebral Small Vessel Diseases|Cerebral Small Vessel Ischemic Disease|Lacunar Stroke
Interventions: DIAGNOSTIC_TEST: 7 Tesla Magnetic Resonance Imaging|OTHER: Brief Memory and Executive Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Vitamin D3 Supplementation in Paediatric Autism
Status: COMPLETED
Conditions: Autism
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinic Navigation and Home Visits to Improve Guideline-based Care and Outcomes in Low Income Minority Adults With Asthma
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: BEHAVIORAL: Clinical intervention|BEHAVIORAL: Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus
Status: COMPLETED
Conditions: Patent Ductus Arteriosus|Neonate
Interventions: DRUG: Acetaminophen|DRUG: ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Observation of Titration Induction and Convention Induction of Propofol
Status: COMPLETED
Conditions: Propofol Overdose of Undetermined Intent
Interventions: PROCEDURE: titration induction to propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Reliability and Validity Tele-assessment of The TUG Test and 30s-CST
Status: COMPLETED
Conditions: Tele-assessment|The Timed Up & Go Test|Stroke|30second Chair-Stand Test
Interventions: OTHER: The Timed Up & Go Test and 30second Chair-Stand Test'
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Observer Presence and Type on Patients' Perception of Exercise After Bone Tumor Resection-A Qualitative Study
Status: UNKNOWN
Conditions: Bone Cancer|Tumor
Interventions: OTHER: Supervised Exercise by a physiotherapist via face to face|OTHER: Supervised Exercise by a physiotherapist via video conference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
Status: RECRUITING
Conditions: Eosinophilic Granulomatosis With Polyangiitis|Churg-Strauss Syndrome
Interventions: DRUG: NS-229|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality in Awake Surgery : Pilot Study VIRAS
Status: RECRUITING
Conditions: Surgery
Interventions: OTHER: Training session with the virtual reality mask|OTHER: Monitoring of the device|OTHER: Acceptability of the device|OTHER: Patient state of anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive Enhancing IDH-1 Mutant Glioma
Status: RECRUITING
Conditions: Astrocytoma
Interventions: DRUG: Vorasidenib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Immunotherapy Treatment for Patients With Hypersensitivity to Grass Pollen
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: BIOLOGICAL: Allergen extract (Phleum pratense)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies Empowering Activities in Everyday Life: An Internet-based Occupational Therapy Intervention
Status: NOT_YET_RECRUITING
Conditions: Chronic Disease
Interventions: BEHAVIORAL: Strategies Empowering Activities in Everyday life (SEE 2.0)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Pain, Anxiety and Depression in Patients With Resectable Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Carboplatin（ neoadjuvant）|DRUG: Paclitaxel （neoadjuvant）|DRUG: Anti-PD-1 Drugs|PROCEDURE: Surgical resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Efficacy and Safety of Recombinant Somatroipn in Patients With Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: somatropin|DRUG: Eutropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics & Safety Study of Clopidogrel 75mg and Aspirin 100mg Coadministration
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DRUG: G0041(75/100mg)|DRUG: Clopidogrel & Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alcohol and Bariatric Surgery
Status: TERMINATED
Conditions: Obesity
Interventions: OTHER: Oral Alcohol challenge test Alcohol visit first|OTHER: Oral Alcohol challenge test Placebo visit first|OTHER: Intravenous Alcohol Challenge Test (Clamp)|OTHER: Intravenous Alcohol Self-administration Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CHronic Nonbacterial Osteomyelitis International Registry
Status: RECRUITING
Conditions: Chronic Nonbacterial Osteomyelitis|Chronic Recurrent Multifocal Osteomyelitis
Interventions: DRUG: Methotrexate|DRUG: Sulfasalazine|DRUG: Leflunomide|DRUG: Pamidronate|DRUG: Zoledronic acid|DRUG: Etanercept|DRUG: Adalimumab|DRUG: Certolizumab|DRUG: Infliximab|DRUG: Golimumab|DRUG: NSAID
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: RECRUITING
Conditions: Xerostomia
Interventions: DRUG: D-Limonene Gelcaps|RADIATION: Intensity modulated radiotherapy (IMRT)|DRUG: Cisplatin|OTHER: Xerostomia questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma (SLL)|Diffuse Large B Cell Lymphoma (DLBCL)|Follicular Lymphoma (FL)|Mantle Cell Lymphoma (MCL)|Marginal Zone Lymphoma (MZL)|Waldenstrom Macroglobulinemia (WM)|Primary Central Nervous System Lymphoma (PCNSL)
Interventions: DRUG: NX-5948
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aprepitant Injectable Emulsion in Patients With COVID-19 (GUARDS-1)
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Aprepitant injectable emulsion|DRUG: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics, Pharmacodynamics and Safety Study of Warfarin in Combination With Tamiflu (Oseltamivir)
Status: COMPLETED
Conditions: Drug Therapy, Combination
Interventions: DRUG: Oseltamivir|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Hysteroscopic Morcellator (HM).
Status: COMPLETED
Conditions: Large Intrauterine Polyps|Smaller Type 0 and 1 Myomas|Residual Placental Tissue
Interventions: PROCEDURE: Hysteroscopic morcellator|PROCEDURE: Resectoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability and Oxidative Stress
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Sitagliptin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Market Clinical Follow-up of EUROSTEM Femoral Stem
Status: ACTIVE_NOT_RECRUITING
Conditions: Hip Osteoarthritis|Hip Arthropathy|Hip Arthritis|Hip Necrosis|Hip Fractures|Hip Dysplasia
Interventions: DEVICE: hip arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Photorefractive Keratectomy (PRK) and Sub-Bowman's Keratomileusis (SBK)
Status: COMPLETED
Conditions: Myopia
Interventions: PROCEDURE: PRK|PROCEDURE: SBK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity, Partially HLA Mismatched BMT to Treat Hematologic Malignancies
Status: RECRUITING
Conditions: Hematologic Malignancies
Interventions: DRUG: Fludarabine|DRUG: Cytoxan|RADIATION: Total Body Irradiation|PROCEDURE: Allogeneic Blood or Marrow Transplant|PROCEDURE: Peripheral Blood Stem Cell Transplant|DRUG: Mycophenolate Mofetil|DRUG: Sirolimus|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREFERS (Preserved and Reduced Ejection Fraction Epidemiological Regional Study) Stockholm Heart Failure Study
Status: COMPLETED
Conditions: Heart Failure, Diastolic|Heart Failure，Congestive
Interventions: DIAGNOSTIC_TEST: Cardiac imaging in the PREFERS and CABG PREFERS cohorts|OTHER: Biomarker analysis in the PREFERS and CABG PREFERS chorts|PROCEDURE: Cardiac biopsies in the CABG PREFERS cohort
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FIH Ph 1 Study of TRPC5 Channel Inhibitor GFB-887 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: GFB-887|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Improvement Obtained by Endoscopic Ilio-Psoas Tenotomy (Lesser Trochanter Versus Acetabular Notch)
Status: RECRUITING
Conditions: Tendinopathy
Interventions: PROCEDURE: Endoscopic tenotomy surgery of the iliopsoas tendon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Oral Darinaparsin (ZIO-101-C)in Advanced Solid Tumors and Non-Hodgkin's Lymphomas
Status: UNKNOWN
Conditions: Advanced Cancer
Interventions: DRUG: ZIO-101-C (Darinaparsin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Loss of Control Eating Following Weight Loss Surgery
Status: COMPLETED
Conditions: Loss of Control Eating
Interventions: BEHAVIORAL: Standard-of-Care|BEHAVIORAL: Behavioral Weight Loss Treatment|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients
Status: RECRUITING
Conditions: Hypothyroidism; Irradiation
Interventions: DRUG: Levothyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Home Hospital for Suddenly Ill Adults
Status: UNKNOWN
Conditions: Infection|Heart Failure|COPD|Asthma|Gout Flare|Chronic Kidney Diseases|Hypertensive Urgency|Atrial Fibrillation Rapid|Anticoagulants; Increased
Interventions: OTHER: Home Hospitalization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Placebo|DRUG: ISIS 757456
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of BPA on Insulin and Glucose Responses
Status: COMPLETED
Conditions: Environmental Exposure
Interventions: OTHER: Placebo|OTHER: BPA 4 ug/kg BW|OTHER: BPA 50 ug/kg BW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MEthylprednisolone Administered Intravenously for the Treatment of Patients With Active AnkyLosing spondyLitis (METALL)
Status: UNKNOWN
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) Profiles of Tenofovir Disoproxil Fumarate (TDF) 300 mg in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: TDF tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing The Effect On Cognition Of Adjunctive Therapy With Zonisamide Versus Sodium Valproate
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Zonisamide|DRUG: Sodium valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Supplementation With Butyrate in Individuals With Liver Steatosis and Metabolic Syndrome
Status: COMPLETED
Conditions: NAFLD|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Food for special medical purposes with calcium butyrate, zinc gluconate and vitamin D3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
Status: RECRUITING
Conditions: Fractures, Bone|Nonunion of Fracture|Fractures, Open|Fractures, Ununited|Fracture, Tibial|Fracture of Femur|Fracture Arm
Interventions: OTHER: Vivigen Cellular Bone Matrix
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extended Release Amantadine Safety and Efficacy Study in Levodopa-Induced Dyskinesia (EASED Study)
Status: COMPLETED
Conditions: Dyskinesia|Levodopa Induced Dyskinesia|Parkinson's Disease
Interventions: DRUG: ADS-5102 (extended release amantadine HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of DTP/HB/Hib (Bio Farma)Compared to DTP/HB Given Simultaneously With Hib(Registered)Vaccine
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: DTP/HB/Hib vaccine|BIOLOGICAL: DTP/HB and Hib vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Human-derived Human Milk Fortifiers (H2MF), Gut Microbiota and Oxidative Stress in Premature Infants
Status: COMPLETED
Conditions: Very Low Birth Weight Baby|Premature Birth|Microbial Colonization|Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: H2MF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized, Controlled Trial - Lactoferrin Prevention of Diarrhea in Children
Status: COMPLETED
Conditions: Diarrhea|Malnutrition
Interventions: DIETARY_SUPPLEMENT: bovine lactoferrin|DIETARY_SUPPLEMENT: placebo [maltodextrin]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Can Chronic Post-surgical Pain be Reduced by Preserving Intercostobrachial Nerve During Axillary Lymph Node Dissection? : A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Breast Cancer|Chronic Pain|Intercostobrachial Nerve Injury
Interventions: PROCEDURE: Intercostobrachial Nerve Preserving Axillary Lymph Node Dissection|PROCEDURE: Intercostobrachial Nerve Sacrificing Axillary Lymph Node Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of ATMX in Treating Adolescents With ADHD and SUD
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity|Substance-Related Disorders
Interventions: DRUG: Atomoxetine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Chinese Medicine Nuan-gong-ye on Primary Dysmenorrhea
Status: RECRUITING
Conditions: Chinese Medicine|Primary Dysmenorrhea
Interventions: DRUG: Nuan-gong-ye|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: European Multicenter Study Radiofrequency (RF) Versus Cryo in Atrioventricular Nodal Reentry Tachycardia (AVNRT)
Status: COMPLETED
Conditions: Atrioventricular Nodal Reentry Tachycardia
Interventions: PROCEDURE: RF-ablation|PROCEDURE: cryo ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCSD Q10 and Aging Study
Status: COMPLETED
Conditions: Age Related Symptoms|Age Related Quality of Life Issues
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|DIETARY_SUPPLEMENT: Coenzyme Q10|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Integrating Solution Focused Interventions in Integrated Care
Status: COMPLETED
Conditions: Depression|Diabetes Mellitus|Hypertension|Anxiety Disorders
Interventions: BEHAVIORAL: Solution Focused Intervention|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of XPF-001 in the Treatment of Pain From Primary/Inherited Erythromelalgia (IEM)
Status: COMPLETED
Conditions: Primary Erythromelalgia|Inherited Erythromelalgia
Interventions: DRUG: XPF-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary, Herbal and Alternative Medicine in Glioblastoma Multiforme
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors|Cerebral Edema
Interventions: DRUG: Boswellia serrata extract|DIETARY_SUPPLEMENT: cyanocobalamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Rolofylline in the Treatment of Patients With Heart Failure (7418-503)
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Comparator: Placebo|DRUG: rolofylline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS)
Status: COMPLETED
Conditions: Lambert Eaton Myasthenic Syndrome
Interventions: DRUG: Amifampridine Phosphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunogenicity of Different Tick Borne Encephalitis (TBE) Fast Protective Traveler Schemes With Inactivated TBE Whole Virus Vaccine
Status: UNKNOWN
Conditions: Tick Borne Encephalitis
Interventions: BIOLOGICAL: FSME vaccination (FSME-Immun)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations
Status: COMPLETED
Conditions: Familial Amyotrophic Lateral Sclerosis
Interventions: DRUG: ISIS 333611
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound
Status: UNKNOWN
Conditions: Healthy|Physiology
Interventions: DRUG: Definity|OTHER: Exercise|OTHER: Kidney Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Pembrolizumab and Cabozantinib in Patients With Metastatic Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of N-acetylcysteine on Performance and Redox Homeostasis
Status: COMPLETED
Conditions: Glutathione Metabolism Anemias
Interventions: DRUG: N-acetylcysteine|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Asciminib Roll-over Study
Status: RECRUITING
Conditions: Chronic Myelogenous Leukemia|Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interventions: DRUG: Asciminib single agent|DRUG: Imatinib|DRUG: Nilotinib|DRUG: Bosutinib|DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial With a New Needle Device Comparing Two Needles for EUS_FNA of Solid Lesions.
Status: UNKNOWN
Conditions: Pancreatic Cancer|Neuroendocrine Tumors|Lymphadenopathies|GIST|Gastric Wall Tumor
Interventions: DEVICE: 25G needle|DEVICE: 22G needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RCT of niPGT for Aneuploidy and Morphology Compared With Morphology Alone in IVF
Status: RECRUITING
Conditions: Preimplantation Diagnosis
Interventions: GENETIC: Non-invasive Preimplantation genetic testing for aneuploidy status
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Effects of tDCS Combined With Balance Training on Postural Control in Chronic Stroke Patients
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of GW483100 10 Milligram (mg) Tablets in Healthy Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Respiratory Disorders|Asthma and Rhinitis
Interventions: DRUG: Test Montelukast|DRUG: Reference Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Empathetic Process by Scanpath Study of an Artwork
Status: COMPLETED
Conditions: Alzheimer Dementia|Parkinson Disease|Fronto-Temporal Dementia
Interventions: OTHER: Eye-Tracking / Neuropsychological evaluations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 89Zr-DFO-Atezolizumab ImmunoPET/CT in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma
Status: RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: 89Zr-DFO-Atezolizumab|PROCEDURE: Positron Emission Tomography/Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating the Safety and Immune Response to Two Admixtures of a Tetravalent Dengue Virus Vaccine
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: TetraVax-DV Vaccine - Admixture TV003|BIOLOGICAL: TetraVax-DV Vaccine - Admixture TV005|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multiple Platelet-Rich Plasma Lateral Epidondylitis Injections Versus a Single Platelet-Rich Plasma Injection
Status: TERMINATED
Conditions: Tennis Elbow|Lateral Epicondylitis
Interventions: OTHER: Platelet Rich Plasma Injection|OTHER: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Robot-Assisted Upper Extremity Training on Cognitive and Physical Functions After Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Robotic group (Upper extremity robot-assisted training plus routine physical and rehabilitation medicine program)|BEHAVIORAL: Control group (routine physical and rehabilitation medicine program)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Rapamycin/Sirolimus for Complicated Vascular Anomalies and Other Susceptible Lesions
Status: RECRUITING
Conditions: Vascular Anomaly
Interventions: DRUG: Topical Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Acyl-Ghrelin on Kidney Function and Blood Pressure in Healthy Volunteers
Status: UNKNOWN
Conditions: Renal Tubular Transport
Interventions: DRUG: Acyl-Ghrelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Extracorporeal Shockwave Therapy on Gait Parameters in Patients With Planter Fascitis
Status: NOT_YET_RECRUITING
Conditions: Plantar Fascitis|Extracorporeal Shockwave Therapy
Interventions: DEVICE: Extracorporeal shockwave therapy|DEVICE: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of a Therapeutic Device to Improve Speech Sound Differentiation in Preterm Infants
Status: RECRUITING
Conditions: Premature Birth
Interventions: DEVICE: smallTalk NICU Active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PAS for Post-SCI Neuropathic Pain
Status: COMPLETED
Conditions: Spinal Cord Injury Cervical|Neuropathic Pain
Interventions: DEVICE: long-term paired associative stimulation|DEVICE: sham long-term paired associative stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Basophilic Leukemia|Adult Acute Eosinophilic Leukemia|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Childhood Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndromes|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: cytarabine|DRUG: idarubicin|DRUG: tipifarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Randomized, Open-label Study to Assess Whether Treatment With Mycophenolate Sodium (MPS) Allows Higher Dose Optimization Versus Mycophenolate Mofetil (MMF) Leading to a Dose Reduction of Tacrolimus. Maximiza Study.
Status: COMPLETED
Conditions: Prophilaxis of Acute Rejection in Patients Receiving a Renal Allograft
Interventions: DRUG: 1|DRUG: 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SPD465 in Adults With Moderately Symptomatic ADHD.
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Neutral salts of dextroamphetamine sulfate, USP, amphetamine sulphate, USP, d-amphetamine saccharate, d, l-amphetamine aspartate monohydrate.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy, Guided Self Help Versus Individual Therapy
Status: COMPLETED
Conditions: Anxiety Disorders|Major Depression|Stress Disorders|Primary Insomnia
Interventions: BEHAVIORAL: Continued self help CBT|BEHAVIORAL: Individual CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Analgesic Requirement|Stress Response|Return of Bowel Activity|Inadequate or Impaired Respiratory Function
Interventions: DRUG: Intraperitoneal Lignocaine|DRUG: Intravenous Lignocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FR01 and FR20 IUS (Intrauterine System) Wearing Study
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Placebo: Flexi ring FR01|DRUG: Placebo: Flexi ring FR20|DRUG: Placebo: Ultra low dose levonorgestrel contraceptive system (LCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: MOTIV BTK Randomized Controlled Trial
Status: RECRUITING
Conditions: Critical Limb Ischemia
Interventions: DEVICE: MOTIV Sirolimus-Eluting Bioresorbable Scaffold|DEVICE: Percutaneous Transluminal Angioplasty (PTA) Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury|Drug Use|Drug Interaction|Drug Toxicity|Drug-Induced Nephropathy|Machine Learning|Newborn Morbidity|Premature Birth
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: Canakinumab|DRUG: Placebo to canakinumab|DRUG: Naproxen|DRUG: Placebo to Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Effects of Drugs: Inpatient (35)
Status: COMPLETED
Conditions: Cocaine Use Disorder
Interventions: DRUG: Cocaine|DRUG: Placebo oral capsule|DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Computerized Exercise Training for Cognitive Remediation in Adults With Multiple Sclerosis Treated With Gilenya
Status: COMPLETED
Conditions: Multiple Sclerosis|Cognitive Deficits|Gilenya Modifying Therapy for MS
Interventions: OTHER: plasticity-based computerized cognitive remediation program|DRUG: Gileyna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TOPical Sirolimus in linGUal Microcystic Lymphatic Malformation -TOPGUN
Status: RECRUITING
Conditions: Lingual Microcystic Lymphatic Malformations
Interventions: DRUG: Sirolimus Oral Liquid Product 1mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Tolerance Evaluation of an Infant Formula
Status: COMPLETED
Conditions: Healthy, Full-term Infants Who Are Formula-fed
Interventions: OTHER: Routine Infant Formula 1|OTHER: Routine Infant Formula 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC
Status: ENROLLING_BY_INVITATION
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Furmonertinib Mesilate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Vigabatrin to Treat Methamphetamine Dependence
Status: TERMINATED
Conditions: Methamphetamine Dependence
Interventions: DRUG: CPP-109 vigabatrin|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Hemodynamics Effect of Glibenclamide on Levcromakalim Assessed by High Resolution Magnetic Resonance Angiography (MRA) Technique in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy Volunteers
Status: UNKNOWN
Conditions: Hemodynamics of Cranial Arteries|Headache|Cerebral Blood Flow
Interventions: DRUG: Levcromakalim|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Muscle Training With and Without Vascular Occlusion of Women With Patellofemoral Pain Syndrome: A Random Clinical Trial
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome|Vascular Occlusion
Interventions: OTHER: Muscle strengthening with vascular occlusion|OTHER: Conventional muscle strengthening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Characteristics and Treatment of Chest Tightness Variant Asthma
Status: UNKNOWN
Conditions: Asthma|Chest Syndrome|Clinical Anxiety|Clinical Depression|Lung Function|Quality of Life|Eosinophilia|Nitric Oxide|Airway Responsiveness|Induced Sputum
Interventions: DRUG: Inhaled corticosteriod/long-acting beta-agonist plus Montelukast|DRUG: Inhaled corticosteriod/long-acting beta-agonist only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Impact of Beta-3 Agonist on Psychological Distress and Blood Flow of the Bladder in Women With Overactive Bladder Syndrome
Status: WITHDRAWN
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Mirabegron 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT