pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: rTMS and EEG in DOC Patients
Status: NOT_YET_RECRUITING
Conditions: Disorder of Consciousness
Interventions: DEVICE: Sham Stimulation for Crossover Study|DEVICE: DLPFC Stimulation for Crossover Study|DEVICE: AG Stimulation for Crossover Study|DEVICE: Sham Stimulation for Parallel Study|DEVICE: DLPFC Stimulation for Parallel Study|DEVICE: AG Stimulation for Parallel Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of ABT-089 in Children With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DRUG: ABT-089|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha Therapy
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Anti-TNF-alpha|DRUG: Methotrexate|DRUG: Placebo|DRUG: RO7123520
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Multifocal Contact Lens to a Traditional Multifocal Contact Lens
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: Lotrafilcon B multifocal contact lens|DEVICE: Omafilcon A multifocal contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate APVO210 in Healthy Subjects, Patients With Psoriasis, and Patients With Ulcerative Colitis
Status: TERMINATED
Conditions: Psoriasis|Ulcerative Colitis
Interventions: BIOLOGICAL: APVO210|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protocol of Multi-domain Attention Training
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Multi-domain Attention Training (MAT)|BEHAVIORAL: Passive information activities (PIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Relevant Outcome Measures for Creatine Transporter Deficiency Patient
Status: RECRUITING
Conditions: Creatine Transporter Defect
Interventions: OTHER: Clinical endpoints|OTHER: Parental questionnaires|OTHER: Quality of life scale|OTHER: Cognitive assessments|OTHER: Language assessments|OTHER: Motor assessments|OTHER: Social assessments|OTHER: 3T MRI|OTHER: Cardiac assessments|OTHER: Biological collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: M-Health for Teen Substance Abuse and Mental Illness Pilot
Status: WITHDRAWN
Conditions: Substance Use Disorders|Post Traumatic Stress Disorder|Adolescent Behavior|Mental Health Disorder
Interventions: OTHER: Mobile Application (working name: Bright Path)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Binimetinib in Combination With Pembrolizumab in Advanced Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Carcinoma
Interventions: DRUG: Binimetinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Migraines and Neurofdeeback Mindfulness
Status: NOT_YET_RECRUITING
Conditions: Chronic Migraine, Headache
Interventions: BEHAVIORAL: Neurofeedback Mindfulness|BEHAVIORAL: Attention Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Radiculopathy Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Radiculopathy
Interventions: PROCEDURE: Anterior discectomy|BEHAVIORAL: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin E-Diffused Highly Cross-Linked Polyethylene Liner
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: E-poly|OTHER: ArComXL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Goal Directed Propofol Sedation With Magnesium Sulphate Versus Dexmedetomidine for ERCP Procedure
Status: COMPLETED
Conditions: Lack of Drug Action
Interventions: DRUG: Dexmedetomidine|DRUG: Magnesium Sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Nitazoxanide Therapy for Patients With COVID-19 Pneumonia
Status: COMPLETED
Conditions: Covid19|Corona Virus Infection|Pneumonia, Viral
Interventions: DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Prospective Observational Study for Early Diagnosis, and Development of Follow-up Protocol and Hearing Rehabilitation Program for Ototoxic Hearing Loss After Chemotherapy for Pediatric Solid Cancer
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor, Childhood
Interventions: OTHER: Chemotherapy involving cisplatin or carboplatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Elevated Platelet Count as Prognostic Factor in Colorectal Cancer With Synchronous Liver Metastases
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Carcinoma|Stage IV Colon Cancer
Interventions: DIAGNOSTIC_TEST: Measurement of platelet count at diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Explore the Therapeutic Effect of HEC585 on Delaying Forced Vital Capacity (FVC) Decline and Tolerance in Progressive Fibrosing Interstitial Lung Disease (PF-ILD) Patients
Status: RECRUITING
Conditions: Progressive Fibrosing Interstitial Lung Disease (PF-ILD) / Progressive Pulmonary Fibrosis (PPF)
Interventions: DRUG: HEC585 dose A|DRUG: HEC585 dose B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Dietary Therapy Using Crohn's Disease Exclusion Diet for Ileal Pouch Anal Anastomosis Patients
Status: UNKNOWN
Conditions: Pouchitis|Crhon's Disease Like of the Pouch
Interventions: OTHER: CDED diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Enteral Versus Parenteral Feeding in Healthy Human Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Enteral Continuous|DIETARY_SUPPLEMENT: Enteral Intermittent|DIETARY_SUPPLEMENT: Parenteral Continuous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chronic Obstructive Pulmonary Disorder and Acute Exercise
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: stable amino acid infusion|OTHER: acute exercise with amino acid infusion|OTHER: 24-hour post exercise amino acid infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Brain Imaging Study in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: I-123-MNI-168|DRUG: 123-I MNI-168
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Weight Loss
Interventions: BEHAVIORAL: Behavioral Treatment|BEHAVIORAL: Mindful Acceptance|BEHAVIORAL: Values|BEHAVIORAL: Mindful Awareness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music Interventions for the Facilitation of Sleep in the Acute Geriatric Setting
Status: UNKNOWN
Conditions: Sleep Disturbance|Insomnia|Music Listening Intervention|Non-musical Sound Listening Intervention
Interventions: OTHER: Music listening intervention|OTHER: Non-musical sounds listening intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Evaluation of Albumin and Starch Effects in Acute Lung Injury (ALI)
Status: TERMINATED
Conditions: Lung Injury, Acute (ALI)|Respiratory Distress Syndrome, Acute (ARDS)
Interventions: DRUG: 5% human albumin|DRUG: 6% hetastarch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AP-325 in Subjects With Peripheral Post-surgical Neuropathic Pain
Status: RECRUITING
Conditions: Peripheral Post-surgical Neuropathic Pain
Interventions: DRUG: AP-325|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lung-protective Ventilation During Robot-assisted Laparoscopic Radical Cystectomy
Status: COMPLETED
Conditions: Lung-protective Ventilation
Interventions: PROCEDURE: lung protective ventilation strategy|PROCEDURE: nonprotective ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety, Tolerability, and Efficacy of Orally Administered PTL201 in MS Patients With Spasticity-related Symptoms
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: PTL201|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Enfortumab Vedotin (ASG-22CE) in Chinese Participants With Locally Advanced or Metastatic Urothelial Cancer Who Previously Received Platinum-containing Chemotherapy and Programmed Cell Death Protein-1 ( PD 1) / (Programmed Death Ligand-1 (PD-L1) Inhibitor Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Urothelial Cancer
Interventions: DRUG: Enfortumab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azithromycin as Adjunctive Treatment for Uncomplicated Severe Acute Malnutrition
Status: NOT_YET_RECRUITING
Conditions: Malnutrition, Child|Severe Acute Malnutrition
Interventions: DRUG: Azithromycin|DRUG: Amoxicillin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hib-MenCY-TT Vaccine Study Compared to Licensed Hib and Meningococcal Serogroup C Conjugate Vaccines
Status: COMPLETED
Conditions: Neisseria Meningitidis|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: MenHibrix (Hib-MenCY-TT)|BIOLOGICAL: Infanrix® Penta|BIOLOGICAL: Prevenar®|BIOLOGICAL: ActHIB®|BIOLOGICAL: Meningitec®|BIOLOGICAL: M-M-R®II|BIOLOGICAL: Varivax®|BIOLOGICAL: PedvaxHIB®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Varenicline and Combined NRT for Smoking Cessation
Status: ACTIVE_NOT_RECRUITING
Conditions: Cigarette Smoker|Tobacco Use Disorder
Interventions: DRUG: Nicotine Lozenge|DRUG: Nicotine Patch|OTHER: Placebo|OTHER: Tobacco Cessation Counseling|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Targeted Gene Transfer in Colorectal Cancer Metastatic to Liver
Status: WITHDRAWN
Conditions: Colorectal Neoplasms
Interventions: GENETIC: Mx-dnG1 Retroviral Vector
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Low Energy Availability and High Impact Jumping on Markers of Bone (re)Modelling in Females
Status: COMPLETED
Conditions: Bone Resorption|Bone Atrophy|Energy Supply; Deficiency|Female Athlete Triad|Relative Energy Deficiency in Sport
Interventions: BEHAVIORAL: Low energy availability|BEHAVIORAL: High impact jumping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Follow-up Study on Total Endoscopic Thyroidectomy Bilateral Areola Approach
Status: COMPLETED
Conditions: Quality of Life
Interventions: PROCEDURE: Endoscopic Thyroidectomy Bilateral Areola Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Immunotherapy in Patients With Metastatic Cancers and CDK12 Mutations
Status: COMPLETED
Conditions: Metastatic Castration Resistant Prostate Cancer|Metastatic Cancer|Solid Tumor
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Sulforaphane in Broccoli Sprout Extract on Breast Tissue
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Broccoli sprout extract|DRUG: Mango juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Coffeeberry Ingestion on Soccer Skill Performance
Status: COMPLETED
Conditions: Skill Performance|Soccer Performance|Coffeeberry Effects
Interventions: DIETARY_SUPPLEMENT: Coffeeberry beverage|OTHER: Comparator beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol)
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: mTHS 2.2|OTHER: mCC|OTHER: NNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension|High Blood Pressure|Ventricular Hypertrophy|Diastolic Dysfunction|Systolic Dysfunction
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Exercise|BEHAVIORAL: Weight Loss|BEHAVIORAL: Low Sodium Diet|BEHAVIORAL: Smoking Cessation|DRUG: Pharmaceutical Therapy (no specific therapy; approach guided by the JNC 7 protocol guidelines)|BEHAVIORAL: Weight Loss|BEHAVIORAL: Low Sodium Diet|BEHAVIORAL: Smoking Cessation|DRUG: Pharmaceutical Therapy (no specific therapy; approach guided by the JNC 7 protocol guidelines)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess in Home Use of Evolocumab (AMG 145) Administration Using Either an Automated Mini-doser or a Prefilled Autoinjector/Pen
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Mixed Dyslipidemia
Interventions: BIOLOGICAL: Evolocumab AMD|BIOLOGICAL: Evolocumab AI/pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus (RAD001) Therapy of Giant Cell Astrocytoma in Patients With Tuberous Sclerosis Complex
Status: COMPLETED
Conditions: Tuberous Sclerosis|Subependymal Giant Cell Astrocytoma
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Efficacy and Safety of Etanercept 50 mg Twice Weekly (BIW) in Rheumatoid Arthritis (RA) Subjects Who Are Sub-Optimal Responders to Etanercept 50 mg Once Weekly (QW)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Energy-Based Lower Eyelid Rejuvenation - Proof of Concept for InMode AccuTite With or Without Morpheus8
Status: COMPLETED
Conditions: Periorbital Edema
Interventions: DEVICE: AccuTite|DEVICE: AccuTite + Morpheus 8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Analgesic and Antiemetic Regimen for Medical Abortion < 70 Days
Status: RECRUITING
Conditions: Nausea|Pain
Interventions: DRUG: Prophylactic use of ibuprofen and ondansetron post misoprostol administration|DRUG: Use of ibuprofen and ondansetron at symptom onset post misoprostol administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants
Status: COMPLETED
Conditions: Viral Pharyngitis|Viral Tonsillitis
Interventions: DIETARY_SUPPLEMENT: mixture of aromatic essential oils.|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electrical Stimulation Improves Exercise Tolerance in Patients With Advanced Heart Failure on Continuous Dobutamine Use
Status: COMPLETED
Conditions: Heart Failure|Ventricular Dysfunction, Left
Interventions: DEVICE: Neuromuscular Electrical Stimulator|OTHER: Physical Therapy Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: This Study Will Evaluate the Effect of Canakinumab or Pembrolizumab Given as Monotherapy or in Combination as Neo-adjuvant Treatment for Subjects With Early Stages NSCLC.
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Canakinumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BST-236 as a Single Agent in Adults With Relapsed or Refractory AML or HR-MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes|Acute Myeloid Leukemia
Interventions: DRUG: BST-236
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Recombinant Human Growth Hormone (r-hGH), Saizen®, on a Population of Children With Hypochondroplasia, Treated at Least 3 Years or Until Near Final Height, When Applicable, in Comparison With a Historic Cohort of Non-treated Children
Status: COMPLETED
Conditions: Hypochondroplasia
Interventions: DRUG: Recombinant human growth hormone (r-hGH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Early Knee Osteoarthritis With Autologous Adipose-derived Mesenchymal Stem Cells
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: Autologous adipose-derived mesenchymal stem cells|PROCEDURE: abdominal liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Collect and Assess Safety Data for a Radiofrequency Microneedling Device for Electrocoagulation and Hemostasis of Soft Tissues for Dermatologic Conditions
Status: RECRUITING
Conditions: Wrinkle|Fine Lines|Crepey Skin|Acne Scars|Active Acne|Enlarged Pores|Stretch Mark|Loose Skin
Interventions: DEVICE: RadioFrequency Microneedling Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions
Status: WITHDRAWN
Conditions: Skin Lesion
Interventions: DRUG: Cephalexin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chidamide Plus Azacitidine for the Treatment of Previously Untreated Nodal TFH Cell Lymphoma
Status: RECRUITING
Conditions: Peripheral T Cell Lymphoma|Epigenetic Repression
Interventions: DRUG: Chidamide|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Perioperative Photograph as a Motivation for Increasing Range of Motion After Primary Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Received perioperative photograph|PROCEDURE: Didn't receive perioperative photograph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of Oral ON 01910.Na in Patients With Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: ON 01910.Na
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Twenty-six Week Extension Trial of Org 50081 (Esmirtazapine) in Outpatients With Chronic Primary Insomnia (176003/P05721/MK-8265-007)
Status: TERMINATED
Conditions: Sleep Initiation and Maintenance Disorders|Mental Disorders|Dyssomnias|Sleep Disorders|Sleep Disorders, Intrinsic
Interventions: DRUG: esmirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of SBIRT-PN
Status: COMPLETED
Conditions: Substance Use|HIV/AIDS|Older Adults|Behavioral Intervention|Infectious Disease
Interventions: BEHAVIORAL: Psycho-educational content (5 Minutes)|BEHAVIORAL: Readiness Assessment (10 minutes)|BEHAVIORAL: Goal-Setting (5 minutes)|BEHAVIORAL: Identifying and prioritizing needs (5 minutes)|BEHAVIORAL: Explanation of Peer Navigator and Session wrap (5 minutes)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: "Hyaluronan" Formulation for Dry Mouth in Sleep Apnea Patients
Status: UNKNOWN
Conditions: Dry Mouth|Xerostomia|OSA|Sleep Apnea
Interventions: DEVICE: Test Oral Spray|DEVICE: Placebo Oral Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Determine the Efficacy of Near Infrared Spectroscopy to Detect Intracranial Hemorrhage in Children
Status: COMPLETED
Conditions: Intracranial Hemorrhage
Interventions: DEVICE: Near Infrared Spectroscopy (NIRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Management of Hypertension and Multiple Risk Factors to Enhance Cardiovascular Health
Status: UNKNOWN
Conditions: Hypertension|Cardiovascular Disease
Interventions: OTHER: Structured Multicomponent Intervention (MCI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively
Status: RECRUITING
Conditions: Hemophilia A|Hemophilia B
Interventions: DIAGNOSTIC_TEST: Testing of hepatic AAV Vector integration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)
Status: COMPLETED
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: KSI-301|DRUG: Aflibercept|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Negative Pressure Wound Closure Therapy by PICO System in Prevention of Complications of Femoral Artery Exposure
Status: UNKNOWN
Conditions: Wound Infection|Wound Surgical
Interventions: PROCEDURE: Femoral Wound Closure and dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Celliant Socks to Increase Tissue Oxygenation and Complete Wound Closure in Diabetic Foot Wounds
Status: TERMINATED
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: Celliant Diabetic Medical Socks|DEVICE: Control (placebo) Medical Socks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: E7080 in Combination With Carboplatin and Paclitaxel in Patients With Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: E7080|DRUG: E7080|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Insulin Therapy in the Hospital Comparing Two Protocols
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Glargine insulin|DRUG: NPH insulin and regular insulin|DRUG: lispro insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-amino Acid Oxidase Inhibition (DAAOI-1) add-on Treatment for Chronic Schizophrenia
Status: COMPLETED
Conditions: Schizophrenias|Psychoses|Psychotic Disorders|Schizophrenic Disorders
Interventions: DRUG: D-amino acid oxidase inhibition (DAAOI-1)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resources-Oriented Salutogenic (ROS) Intervention for Pre-diabetes
Status: RECRUITING
Conditions: Sense of Coherence|Salutogenesis|PreDiabetes
Interventions: BEHAVIORAL: Resources-Oriented Salutogenic (ROS) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: (ARFI) Shear Velocity Imaging of the Kidneys in Pediatric Patients
Status: WITHDRAWN
Conditions: Urine Reflux|Kidney Damage
Interventions: PROCEDURE: ARFI SVI Ultrasound Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate the Efficacy and Safety of the Cilostazol-coated BioMimics 3D Stent System in Patients With Peripheral Arterial Occlusive Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Standard stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microdosed Atropine 0.1% and 0.01% Ophthalmic Solutions for Reduction of Pediatric Myopia Progression
Status: RECRUITING
Conditions: Myopia
Interventions: DRUG: Atropine 0.1% Ophthalmic Solution|DRUG: Atropine 0.01% Ophthalmic Solution|DRUG: Placebo Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Propofol or Benzodiazepine Combined With Ketamine for Procedural Sedation in Emergency Setting
Status: NOT_YET_RECRUITING
Conditions: Procedural Sedation
Interventions: DRUG: ketamine- midazolam versus ketamine- propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ascending Multiple Intravenous Doses of AON-D21 in Healthy Male Subjects.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AON-D21|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab and Radiation in Muscle-Invasive Bladder Cancer
Status: RECRUITING
Conditions: Bladder Cancer|Muscle Invasive Bladder Cancer
Interventions: DRUG: Avelumab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AF Burden and Echo-guided Persistent AF Ablation Strategy Using Either PV Isolation Alone (CLOSE Protocol) or Optimized Compartmentalization of the Left Atrium (Pseudo-maze Technique)
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: PVI only|PROCEDURE: PVI with substrate ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Device-guided Breathing Exercises on Blood Pressure in Diabetic Patients
Status: COMPLETED
Conditions: Hypertension in Type 2 Diabetes
Interventions: DEVICE: Resperate|DEVICE: Resperate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BAX 855 Dose-Escalation Safety Study
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method|BIOLOGICAL: PEGylated Recombinant Factor VIII
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Liver Transplantation
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Tacrolimus modified-release|DRUG: Prograf
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Study of Enhanced CD33 CAR T Cells in Subjects With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Relapse Leukemia|Refractory Acute Myeloid Leukemia
Interventions: BIOLOGICAL: chimeric antigen receptor T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimum Radiographic Assessment of the Knee
Status: TERMINATED
Conditions: Osteoarthritis, Knee
Interventions: RADIATION: Valgus Stress|RADIATION: Varus stress|RADIATION: 0 degree flexion radiograph|RADIATION: 20 degree flexion radiograph|RADIATION: 45 degree flexion radiograph
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Utilization of Hepatitis B Virus NAT+ Donors for Hepatitis B Vaccinated Lung Transplant Candidates
Status: WITHDRAWN
Conditions: Lung Transplant|Hepatitis B
Interventions: DRUG: Hepatitis B Immune Globulin and entecavir, tenofovir disoproxil, or tenofovir alafenamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban 2.5 mg BID and Aspirin for Intermittent Claudication in PAD Patients
Status: COMPLETED
Conditions: Peripheral Artery Disease|Intermittent Claudication
Interventions: DRUG: Rivaroxaban 2.5 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Treatment by the Corsano CardioWatch 287-2 Evaluation Study
Status: RECRUITING
Conditions: High Blood Pressure
Interventions: DEVICE: Corsano CardioWatch 287-2 non-invasive blood pressure (NIBP) monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Survival Benefit of Primary Tumour Resection Compared to Systemic Therapy Alone in Stage IV Colorectal Cancer Patients
Status: COMPLETED
Conditions: Colorectal Cancer|Neoadjuvant Systemic Therapy
Interventions: PROCEDURE: Primary tumor resection|PROCEDURE: Systemic Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HMPL-453 Food Effect and PPI Study in Healthy Volunteer Study
Status: COMPLETED
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: HMPL-453|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Holistic Health Program for United Methodist Clergy
Status: COMPLETED
Conditions: Obesity|Depression|Diabetes|Hypertension|Hypercholesterolemia
Interventions: BEHAVIORAL: Holistic health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Duration of Analgesia After Popliteal Fossa Sciatiac Nerve Block With Ropivacaine 0.5% When Combined With Placebo, Dexamethasone 4mg or Dexamethasone 8 mg
Status: WITHDRAWN
Conditions: Pain, Sciatic Block
Interventions: DRUG: Placebo|DRUG: Dexamethasone 4 mg|DRUG: Dexamethasone 8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum NSAIDS and Maternal Hypertension
Status: UNKNOWN
Conditions: Preeclampsia|Gestational Hypertension|Superimposed Preeclampsia|Chronic Hypertension in Obstetric Context
Interventions: DRUG: Ibuprofen 600 mg|OTHER: Standard Postpartum Care without NSAIDs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory B-Lineage Leukaemia / Lymphoma - A Feasibility Protocol
Status: RECRUITING
Conditions: Lymphoblastic Leukemia|Lymphoblastic Leukemia in Children|Lymphoblastic Leukemia, Acute Adult|B-cell Acute Lymphoblastic Leukemia|Large B-cell Lymphoma|CAR
Interventions: BIOLOGICAL: Anti-CD19 CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib|BIOLOGICAL: Nivolumab|BIOLOGICAL: Ipilimumab|DRUG: Cabozantinib-matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Migraine and Recurrent Abdominal Pain in Children
Status: UNKNOWN
Conditions: Migraine|Abdominal Pain
Interventions: BEHAVIORAL: thermal biofeedback|BEHAVIORAL: relaxation training|BEHAVIORAL: cognitive coping skills|BEHAVIORAL: parent education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of VLX-1005 Versus Placebo in Suspected Heparin Induced Thrombocytopenia
Status: RECRUITING
Conditions: Thrombocytopenia, Immune|Heparin Induced Thrombocytopenia
Interventions: DRUG: VLX-1005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Killer Immunoglobulin-Like Receptor Transcripts Expression for the Diagnosis of Epidermotropic Cutaneous T Cell Lymphoma
Status: COMPLETED
Conditions: Mycosis Fungicides|Sezary Syndrome|Dermatitis|Dermatitis, Exfoliative
Interventions: OTHER: Detection of KIR receptor by RT PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intraoperative MRI-guidance in Frameless Stereotactic Biopsies
Status: TERMINATED
Conditions: Primary Brain Tumour
Interventions: DEVICE: iMRI-guided brain tumour biopsy|DEVICE: Stereotactic frameless brain tumour biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial to Demonstrate the Safety and Efficacy of the OptiVein IV Catheter In a Pediatric Population
Status: COMPLETED
Conditions: Injections, Intravenous|Administration, Intravenous
Interventions: DEVICE: Vasofix Certo Catheter|DEVICE: OptiVein Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Efficacy and Safety of iNK Cells for CAEBV /EBV-HLH After Allo-HSCT
Status: NOT_YET_RECRUITING
Conditions: CAEBV (Chronic Active Epstein-Barr Virus Infection) Syndrome|EBV|Hemophagocytic Lymphohistiocytoses
Interventions: OTHER: NCR300（Allogenic Ipsc-derived Natural Killer cells ）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Delirium Care Protocol After Cardiac Surgery
Status: COMPLETED
Conditions: Delirium, Postoperative
Interventions: OTHER: training nurses and caring for patients to prevent, diagnose, and intervene in postoperative delirium.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PR3-AAV Resilient Remission or PRRR
Status: TERMINATED
Conditions: Granulomatosis With Polyangiitis|Microscopic Polyangiitis|ANCA Associated Vasculitis
Interventions: DRUG: Obinutuzumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of TwiFlow-System for Acute Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism
Interventions: DEVICE: TwiFlow-Thrombectomy Catheter System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Non-invasive Brain Stimulation in Tobacco Use Disorder
Status: UNKNOWN
Conditions: Tobacco Use Disorder
Interventions: DEVICE: Non-invasive brain stimulation (active)|DEVICE: Non-invasive brain stimulation (sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fitbit and Social Support in Knee Replacement Patients & Buddies
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: BEHAVIORAL: Fitbit|BEHAVIORAL: Fitbit+Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multiple-Visit RCT in Teeth With SAP: Interappointment Dressing or Not?
Status: NOT_YET_RECRUITING
Conditions: Endodontically Treated Teeth|Calcium Hydroxide
Interventions: DRUG: Ca(OH)2 as intracanal medicament
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Audio-Visual-Perception-Enhancement (AVWF®) Method in Chronic Pain Patients
Status: COMPLETED
Conditions: Pain|Stress
Interventions: DEVICE: AVWF device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation of Botulinum Toxin in Subjects With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Botulinum toxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Virus-Specific Cytotoxic T-Lymphocytes(CTL), Persistent/Recurrent Viral Infection Post-HSCT (EAP CHALLAH)
Status: NO_LONGER_AVAILABLE
Conditions: EBV Infection|CMV Infection|Adenoviral Infection
Interventions: BIOLOGICAL: Trivirus-Specific CTLs
Study Type: EXPANDED_ACCESS
Clinical trial: Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychosis NOS|Autistic Disorder|Asperger Syndrome|Child Development Disorders, Pervasive|Bipolar I Disorder|Bipolar II Disorder|Mood Disorder NOS|Severe Major Depression With Psychotic Features|Single Episode Major Depression Without Psychotic Symptoms|Severe Mood Disorder With Psychotic Features
Interventions: DRUG: Latuda©
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SCM-AGH in Patients With Moderate to Severe Acute Pancreatitis
Status: COMPLETED
Conditions: Pancreatitis, Acute
Interventions: BIOLOGICAL: SCM-AGH|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage III Uterine Corpus Leiomyosarcoma AJCC v8|Stage IV Uterine Corpus Leiomyosarcoma AJCC v8|Uterine Corpus Leiomyosarcoma
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Core Biopsy|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Intensification of HIV-associated Non-Hodgkin's Lymphoma by Peripheral Blood Cell Transplantation Following Chemotherapy.
Status: TERMINATED
Conditions: HIV Infections|Lymphoma, Non-Hodgkin
Interventions: PROCEDURE: autologous peripheral blood cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeat Surgery for Patients With Post-operative Trachomatous Trichiasis Trial
Status: COMPLETED
Conditions: Trichiasis|Surgery
Interventions: PROCEDURE: BRAP (Bevel/rotate/advance procedure)|PROCEDURE: Trabut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia
Status: COMPLETED
Conditions: Pharmacodynamic Interaction
Interventions: DRUG: 0.0ng/ml Dexmedetomidine|DRUG: 0.4ng/ml Dexmedetomidine|DRUG: 0.6ng/ml Dexmedetomidine|DRUG: 0.8ng/ml Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One-year Persistence to Treatment of Participants Receiving Flixabi or Imraldi: a French Cohort Study
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Spondylitis, Ankylosing|Arthritis, Psoriatic|Crohn's Disease|Colitis, Ulcerative
Interventions: DRUG: Infliximab|DRUG: Adalimumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Highly Conformal, Hypofractionated, Focally Dose Escalated Post-Prostatectomy Radiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer Of Prostate|Prostate Neoplasms|Prostate Cancer|Neoplasms of Prostate|Prostatic Cancer
Interventions: RADIATION: Prostate bed with integrated boost|RADIATION: Prostate bed irradiation only|DIAGNOSTIC_TEST: Whole Body Bone Scan|DIAGNOSTIC_TEST: 18F-NaF PET Imaging|DIAGNOSTIC_TEST: CT|DIAGNOSTIC_TEST: mpMRI|DRUG: ADT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: SMR neurofeedback training to MCI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ATH-1017 for Treatment of Mild to Moderate Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Dementia of Alzheimer Type
Interventions: DRUG: ATH-1017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT