pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Comparison of PRC-063 and Lisdexamfetamine in the Driving Performance of Adults With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: PRC-063|DRUG: lisdexamfetamine dimesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Absorption of Peroral Insulin in Dextran Matrix (ORA3)
Status: SUSPENDED
Conditions: Diabetes Mellitus
Interventions: DRUG: Insulin in dextran matrix capsule (and placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Posiphen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Study the Effect of Short-chain Fructooligosaccharides in Women With Irritable Bowel Syndrome
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome|Diarrhea- Irritable Bowel Syndrome|Constipation-predominant Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Short Chain Fructooligosaccharides|OTHER: Corn Starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic ACL Reconstruction: Hamstring Versus Quadriceps
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury|Anterior Cruciate Ligament Rupture
Interventions: PROCEDURE: Hamstring|PROCEDURE: Quadriceps tendon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of OSFIT Drug-Eluting Stent in Coronary Ostial Artery Stenosis
Status: RECRUITING
Conditions: Drug-eluting Stent|Coronary Artery Disease
Interventions: DEVICE: Genoss® DES system, Genoss® Osfit system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Study Between Pulse Therapy With Oral Itraconazole Versus Continuous Oral Terbinafine Therapy for Treatment of Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: itraconazole|DRUG: terbinafine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous ex Vivo Conjunctival Epithelial Cell Expansion for Ocular Surface Transplantation
Status: COMPLETED
Conditions: Pterygium|Ocular Surface Disease|Stevens Johnson Syndrome|Chemical Injury
Interventions: PROCEDURE: Cultivated conjunctival transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Centella Asiatica in the Elderly
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy|Elderly
Interventions: DRUG: 2g Centella asiatica water extract product|DRUG: 4g Centella asiatica water extract product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The SHARED, Project, Lung Cancer Screening for African American Men (AAM)
Status: COMPLETED
Conditions: Lung Cancer Screening
Interventions: OTHER: Educational Video about LDCT lung cancer screening|OTHER: A culturally tailored shared decision-making tool|OTHER: Flip chart|OTHER: Navigation support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Taclonex Ointment With Hydrogel Patch Occlusion for the Treatment of Psoriasis
Status: TERMINATED
Conditions: Plaque Psoriasis|Psoriasis Vulgaris
Interventions: DRUG: Taclonex Ointment and Hydrogel Patch|DRUG: Taclonex Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progesterone and Second Trimester Bleeding
Status: TERMINATED
Conditions: Antepartum Bleeding|Preterm Birth
Interventions: DRUG: micronized progesterone 200 mg (Utrogestan)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Computed Tomography|BIOLOGICAL: Mezigdomide|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Exercise Before Surgery in Women With Pelvic Organ Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Pelvic Floor Disorders
Interventions: BEHAVIORAL: pelvic floor exercises|OTHER: Waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib (VELCADE), Cladribine and Rituximab (VCR) in Mantle Cell Lymphoma (PSHCI 10-011)
Status: UNKNOWN
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Rituximab|DRUG: bortezomib|DRUG: Cladribine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intranasal Insulin on Depressive Symptoms in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Diluent / Insulin|DRUG: Insulin / Diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NOVAPAK Nasal Packing in Shellfish Allergic Patients
Status: NOT_YET_RECRUITING
Conditions: Shellfish Hypersensitivity|Epistaxis
Interventions: DEVICE: NOVAPAK nasal packing applied to forearm|DEVICE: NOVAPAK nasal packing applied to nasal cavity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Inhaled DMC-IH1 and Intramuscular (EpiPen®) Epinephrine in Healthy Male and Female Participants.
Status: COMPLETED
Conditions: Anaphylactic Reaction
Interventions: DRUG: Epinephrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Usability of an App Promoting Healthy Behaviours Amongst Young Women at Increased Risk of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Overweight and Obesity|Diet, Healthy|Weight Gain|Alcohol Drinking|Smoking Behaviors|Healthy Nutrition|Healthy Lifestyle|Healthy Eating Index
Interventions: BEHAVIORAL: App Promoting Healthy Behaviours
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Status: NOT_YET_RECRUITING
Conditions: B-cell Malignancies
Interventions: DRUG: AZD5492
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pegasys® Plus Ribavirin in Thalassemic Patients With Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Hepatitis C|Thalassemia
Interventions: DRUG: PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalating Study of SGX942 for Oral Mucositis in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: SGX942|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Ovarian Drilling Versus Letrozole In Clomiphene Citrate Resistant Polycystic Ovary
Status: UNKNOWN
Conditions: Induction of Ovulation
Interventions: DRUG: group A 2.5 mg letrozole oral tablets|PROCEDURE: laparoscopic ovarian drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of SQ-Kyrin TMVr System for Functional Mitral Regurgitation
Status: ACTIVE_NOT_RECRUITING
Conditions: Functional Mitral Regurgitation
Interventions: DEVICE: SQ-Kyrin Transcatheter Mitral Valve Repair System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ablation Versus Medical Management of Atrial Fibrillation in HFpEF
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation|Heart Failure With Normal Ejection Fraction
Interventions: PROCEDURE: Pulmonary Vein Isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Plus Prednisone In Patients With Metastatic Castration-Resistant Prostate Cancer After Failure Of Docetaxel Chemotherapy
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Prednisone|DRUG: sunitinib|DRUG: Placebo|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS ANGPTL3-LRx in Healthy Volunteers With Elevated Triglycerides and Participants With Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Hypertriglyceridemia|Familial Hypercholesterolemia
Interventions: DRUG: IONIS ANGPTL3-LRx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: FL3X Study: An Adaptive Intervention to Improve Outcomes for Youth With Type 1 Diabetes (FL3X)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: FL3X: Flexible Lifestyle Empowering Change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapsone Prurigo Study
Status: UNKNOWN
Conditions: Lichen Simples Chronicus and Prurigo
Interventions: DRUG: Dapsone gel - verum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thymosin Alfa 1 in Recipients of Allogeneic Hematopoietic Transplantation for Hematological Malignancies
Status: UNKNOWN
Conditions: Hematological Malignancies
Interventions: DRUG: Thymosin alpha 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traditional Septoplasty Vs Endoscopic Septoplasty for Treating Deviated Nasal Septum
Status: UNKNOWN
Conditions: Intranasal Surgery
Interventions: PROCEDURE: Endoscopic septoplasty|PROCEDURE: Traditional septoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PROMISE EBF: Safety and Efficacy of Exclusive Breastfeeding Promotion in the Era of HIV in Sub-Saharan Africa
Status: COMPLETED
Conditions: Diarrhea
Interventions: BEHAVIORAL: Peer-support for exclusive breastfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Coronary Bifurcation Lesions: Comparing Reverse T and Protrusion Versus Double-kissing and Crush Stenting
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: DK crush|PROCEDURE: Reverse TAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-951 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: TAK-951|DRUG: TAK-951 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Expanded Access Program: Safety of Erythrocytes Encapsulating L-asparaginase (GRASPA®) in Combination With Polychemotherapy in Patients Under 55 Years Old With Acute Lymphoblastic Leukemia (ALL) at Risk to Receive Other Formulation of Asparaginase
Status: NO_LONGER_AVAILABLE
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: suspension of erythrocytes encapsulating L-asparaginase
Study Type: EXPANDED_ACCESS
Clinical trial: Nocturnal Transnasal Insufflation (nTNI)
Status: COMPLETED
Conditions: COPD|Hypercapnia
Interventions: DEVICE: humidified transnasal insufflation (TNI20oxy)|OTHER: overnight oxygen treatment with individual flow rate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib Hydrochloride Capsule in Subjects With Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Anlotinib|DRUG: Placebos|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive-behavioral Therapy vs. Light Therapy for Preventing SAD Recurrence
Status: COMPLETED
Conditions: Seasonal Affective Disorder (SAD)|Winter Depression|Major Depressive Disorder, Recurrent, With Seasonal Pattern
Interventions: BEHAVIORAL: Cognitive-Behavioral Therapy (CBT)|DEVICE: Light Therapy (LT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Uses of Irradiated Human Amniotic Membrane in the Treatment of Dystrophic Epidermolysis Bullosa Patients
Status: COMPLETED
Conditions: Epidermolysis Bullosa|Chronic Skin Ulcer
Interventions: BIOLOGICAL: REGE pro dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Factors for Response to New Oral Anticoagulants in the Treatment of Non-valvular Atrial Fibrillation..
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Apixaban|DRUG: Edoxaban|DRUG: Rivaroxaban|DRUG: Dabigatran
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Buparlisib in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Mantle Cell Lymphoma|Transformed Recurrent Non-Hodgkin Lymphoma
Interventions: DRUG: Buparlisib|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Regional Lung Deposition of Inhaled Saline Using the tPAD Device
Status: COMPLETED
Conditions: Lung Diseases
Interventions: DEVICE: tPAD Device|DEVICE: PARI LC Star Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Safety and Efficacy of the Therapeutic Vaccine GI-4000 in Combination With Gemcitabine Versus Placebo for the Treatment of Non-metastatic, Post-resection Pancreas Cancer
Status: COMPLETED
Conditions: Pancreas Cancer
Interventions: BIOLOGICAL: GI-4000|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Motor Imagery in Fine Motor Skills
Status: COMPLETED
Conditions: Mental Retardation and Developmental Disabilities With No Organic Condition
Interventions: BEHAVIORAL: Motor Imagery + Psychomotor Battery of fine motor skills|BEHAVIORAL: Psychomotor Battery of fine motor skills Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral 25-hydroxyvitamin D3 and COVID-19
Status: UNKNOWN
Conditions: COVID 19
Interventions: DRUG: Oral 25-Hydroxyvitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prioritization of Cerebral Deoxygenation in Severe Traumatic Brain Injury and Mortality Benefit.
Status: COMPLETED
Conditions: Cerebral Hypoxia|Severe Traumatic Brain Injury
Interventions: DEVICE: Near infrared spectroscopy neuromonitor to prevent cerebral desaturation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of LY3471851 in Participants With Eczema
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: LY3471851|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety And Efficacy Study of Ibuprofen 250 mg / Acetaminophen 500 mg In The Treatment Of Post-Surgical Dental Pain
Status: COMPLETED
Conditions: Post-surgical Pain Following Extraction of Molar Teeth
Interventions: DRUG: Ibuprofen 250 mg / Acetaminophen 500 mg|DRUG: Ibuprofen 250 mg|DRUG: Acetaminophen 650 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Farletuzumab (MORAb 003) in Combination With Carboplatin Plus Paclitaxel or Carboplatin Plus Pegylated Liposomal Doxorubicin (PLD) in Participants With Low CA125 Platinum-sensitive Ovarian Cancer
Status: COMPLETED
Conditions: Platinum-Sensitive Ovarian Cancer in First Relapse
Interventions: DRUG: Farletuzumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of cineMRI to Evaluate Botox in Patients With Medication Refractory Overactive Bladder
Status: RECRUITING
Conditions: Overactive Bladder
Interventions: OTHER: Botulinum toxin and cineMRI-UDS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Regional Block, Caudal Block and Wound Infiltration in Inguinal Hernitomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: regional block|PROCEDURE: Caudal block|PROCEDURE: Epidural
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Silicone Hydrogel Soft Contact Lens 7-Day Extended Wear Basis
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Bausch + Lomb Samfilcon A Soft Contact Lens|DEVICE: Bausch + Lomb Pure Vision Soft Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: To Evaluate Safety and Efficacy of KX-826 in Chinese Female Subjects With Androgenetic Alopecia
Status: COMPLETED
Conditions: Alopecia
Interventions: DRUG: KX-826 dosed at 2.5mg|DRUG: KX-826 dosed at 2.5mg|DRUG: KX-826 dosed at 5 mg|DRUG: KX-826 dosed at 5 mg|DRUG: Matching placebo to KX-826|DRUG: Matching placebo to KX-826
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Treatment for Post-Traumatic Stress Disorder in People With Additional Serious Mental Illnesses
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)|BEHAVIORAL: Brief PTSD treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
Status: COMPLETED
Conditions: Post-ERCP Acute Pancreatitis
Interventions: DRUG: Pre-ERCP rectal Indomethacin|DRUG: Post-operational Rectal Indomethacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Open, Non-randomized Phase I/II Study of Therapeutic Angiogenesis in Diabetic Patients With Critic Ischemia of Lower Limbs While Administering Positive CD133 Mobilized With G-CSF
Status: TERMINATED
Conditions: Diabetic Patients With Critic Ischemia in Lower Limbs Who Are Administered With CD133+ Cells Mobilized by G-CSF
Interventions: BIOLOGICAL: CD133+ cells transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: RO5093151|DRUG: atazanavir|DRUG: ketoconazole|DRUG: rifampicin|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV
Status: RECRUITING
Conditions: Periodontitis|Periodontitis, Adult
Interventions: PROCEDURE: Periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Treatments for Multivessel Coronary Artery Disease in Individuals With Diabetes (FREEDOM)
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Coronary Disease|Diabetes Mellitus|Heart Diseases
Interventions: PROCEDURE: Coronary Artery Bypass Graft|DEVICE: Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Mesothelioma|Non-Small Cell Lung Carcinoma|Pleural Disorder
Interventions: DEVICE: Light Dosimetry for Intranoperative Therapy|PROCEDURE: Photodynamic Therapy|DRUG: Porfimer Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Vascular Disease|Atherosclerosis
Interventions: BIOLOGICAL: Ad2/HIF-1α/VP16|BIOLOGICAL: Ad2/HIF-1α/VP16|BIOLOGICAL: Ad2/HIF-1α/VP16|OTHER: Saline (Placebo Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: Placebo|DRUG: Fludrocortisone|DRUG: D-Cycloserine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Effect of the Physical Activity Promotion on the Clinical Characteristics and Vascular Risk in Patients With Mild-moderate Obstructive Sleep Apnea
Status: RECRUITING
Conditions: Sleep Apnea
Interventions: BEHAVIORAL: Promotion of daily physical activity with a pedometer|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Misoprostol for the Treatment of Postpartum Hemorrhage
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Misoprostol|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Young Adult Tobacco/Nicotine and Cannabis Co-use
Status: RECRUITING
Conditions: Tobacco Use Disorder|Nicotine Dependence
Interventions: BEHAVIORAL: Counseling|BEHAVIORAL: Contingency management|BEHAVIORAL: Text-based support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Efruxifermin in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) (Symmetry)
Status: ACTIVE_NOT_RECRUITING
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: EFX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty
Status: ENROLLING_BY_INVITATION
Conditions: Frailty|Aging
Interventions: DEVICE: Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Bevacizumab in the Treatment of Radiation Necrosis in Children With Central Nervous System Tumors
Status: TERMINATED
Conditions: Radiation Necrosis
Interventions: DRUG: Bevacizumab (Avastin®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin and Chemotherapy in CD30+ PMBL, Diffuse Large B-Cell, and Grey Zone Lymphoma Patients
Status: COMPLETED
Conditions: CD30 Positive Primary Mediastinal Large B-cell Lymphoma|CD30-Positive Diffuse Large B-Cell Lymphoma|CD30-Positive Gray Zone Lymphoma
Interventions: DRUG: brentuximab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics After Single Ascending Intravenous Doses of AZD2927 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD2927|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia
Status: UNKNOWN
Conditions: Anesthesia; Adverse Effect|Laryngeal Masks|Respiratory System Abnormalities
Interventions: DRUG: Desflurane|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Music for Pain in Primary Dysmenorrhea
Status: COMPLETED
Conditions: Pain, Menstrual|Primary Dysmenorrhea
Interventions: BEHAVIORAL: Music group|BEHAVIORAL: Silence Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telemedicine in Palliative Care: Interventions, Experiences and Perceptions of Patients Diagnosed With Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Cancer
Interventions: OTHER: Telemedicine Consultation|OTHER: Face-to-Face Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of a Respiratory Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Patients With Severe Confirmed COVID-19 Pneumonia
Status: COMPLETED
Conditions: Covid19|Pneumonia
Interventions: PROCEDURE: Combined use of a respiratory broad panel multiplex PCR and procalcitonin|OTHER: Usual antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Doses of Aspirin on Pathophysiological Markers in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: Aspirin|DRUG: Aspirin|DRUG: Aspirin|OTHER: placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Apalutamide and Gonadotropin-Releasing Hormone Analog With or Without Abiraterone Acetate in Treating Participants With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|Stage IIB Prostate Cancer AJCC v8|Stage IIC Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone Acetate|DRUG: Apalutamide|BIOLOGICAL: Gonadotropin-releasing Hormone Analog|DRUG: Prednisone|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Alveolar Ridge Preservation Technique on the Need of Performing Guided Bone Regeneration for Dental Implant Placement
Status: UNKNOWN
Conditions: Tooth Avulsion
Interventions: PROCEDURE: Tooth extraction and Alveolar ridge preservation|PROCEDURE: Tooth extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Ultrasound Diagnosis of Chronic Liver Diseases in Hepatology Consultation
Status: COMPLETED
Conditions: Liver Diseases|Liver Cirrhosis|Non-Alcoholic Fatty Liver Disease
Interventions: DEVICE: Ultrasound liver assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Study to Evaluate the Safety and Efficacy of Telomelysin (OBP-301) in Patients With Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: BIOLOGICAL: OBP-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Plus Chemotherapy for Patients With Advanced Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Neoplasms|Docetaxel|Pemetrexed|S-1|Anlotinib
Interventions: DRUG: anlotinib plus chemotherapy|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shade Matching Potential of Universal Shade Resin Composite Materials Compared to Multi Shade Resin Composite in Restoration of Carious Cervical Lesions in Anterior Teeth
Status: UNKNOWN
Conditions: Class V Dental Caries
Interventions: DIAGNOSTIC_TEST: Modified USPHS criteria
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intact-cord Stabilisation and Physiology-based Cord Clamping in Caesarean Sections
Status: COMPLETED
Conditions: Cesarean Section|Infant Conditions
Interventions: PROCEDURE: Extrauterine placental transfusion and physiology-based umbilical cord clamping|PROCEDURE: Extrauterine placental transfusion, intact cord stabilisation and physiology-based umbilical cord clamping|PROCEDURE: Delayed umbilical cord clamping
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Insulin Peglispro and Glargine on Fats in Participants With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Insulin Peglispro|BIOLOGICAL: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Post-hospitalisation Nutritional Support and Gait Speed in COPD
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive|Respiratory Tract Diseases|Lung Diseases, Obstructive|Bronchitis, Chronic|Pulmonary Emphysema
Interventions: DIETARY_SUPPLEMENT: Food fortification|DIETARY_SUPPLEMENT: Oral Nutritional Supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
Status: RECRUITING
Conditions: Suicidal Ideation|Suicidal and Self-injurious Behavior|Suicide|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Safety Planning Intervention tailored for Autistic Individuals|BEHAVIORAL: Safety Planning Intervention Tailored for Autistic Individuals Plus Structured Follow-Up Contacts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Effects of Chronic Ketosis.
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Ketone monoester (3-OHB)|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Controlled Trial Comparing Tension-Free Vaginal Tape (TVT), Pelvicol & Autologous Slings for Stress Urinary Incontinence(SUI)
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: PROCEDURE: Autologous fascial sling|PROCEDURE: TVT|PROCEDURE: Pelvicol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Co-administrated BR1018B and BR1018C
Status: RECRUITING
Conditions: Essential Hypertension|Primary Hypercholesterolemia
Interventions: DRUG: BR1018A|DRUG: BR1018A-1|DRUG: BR1018B|DRUG: BR1018B-1|DRUG: BR1018C|DRUG: BR1018C-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral Colostrum Derived Anti Influenza Antibodies in Healthy Volunteers
Status: UNKNOWN
Conditions: Influenza
Interventions: DIETARY_SUPPLEMENT: colostrum enriched with anti flu antibodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Safety and Effectiveness of Flow Modulation Device for Intracranial Aneurysms
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DEVICE: p64/p48 MW HPC Flow Modulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT
Status: COMPLETED
Conditions: Cetuximab-induced Papulopustular (Acneiform) Rash Who Have|Metastatic Colorectal Cancer or Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Topical Dapsone 5% Gel|OTHER: Moisturizer|DRUG: oral antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia
Status: NOT_YET_RECRUITING
Conditions: Hypophosphatasia
Interventions: DRUG: methotrexate|DRUG: rituximab|DRUG: bortezomib|DRUG: IVIg|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold
Status: NOT_YET_RECRUITING
Conditions: Common Cold
Interventions: DRUG: Acetylcysteine|DRUG: Paracetamol|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Multicenter Study of Different Surgical Methods in the Treatment of High Myopic Macular Schisis
Status: UNKNOWN
Conditions: Macular Schisis
Interventions: PROCEDURE: PPV+/-Cat|PROCEDURE: PPV+/-Cat+Gas|PROCEDURE: PPV+ILM+/-Cat+/-Gas|PROCEDURE: PPV+ILM+/-Cat+/-Oil|PROCEDURE: PSR|PROCEDURE: PSR+ PPV+ILM+/-Cat+/-Oil （or Gas）|PROCEDURE: Gas
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin as Adjuvant to Insulin Therapy in Insulin-resistant Diabetes Mellitus With Pregnancy
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Metformin|DRUG: Humulin Insulin Mixtard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Carnosine as an Adjuvant Therapy for Diabetic Nephropathy in Pediatrics With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Oxidative Stress|Carnosine|Diabetic Nephropathy
Interventions: DIETARY_SUPPLEMENT: Carnosine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Continuous Rhythm Monitoring With Implantable Cardiac Monitors And Wearable Devices With Real-time Smartphone Alerts During AF Episodes
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: LINQII/Apple Watch Series 6|DEVICE: LINQII/SkyLabs CART-I ring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: IPICK Blocking for TKA With Moderate Flexion Contracture
Status: COMPLETED
Conditions: Knee Osteoarthritis|Flexion Contracture of Knees|Anesthesia, Local
Interventions: PROCEDURE: CACB+IPACK|PROCEDURE: CACB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine + Cognitive Training for Suicidality in the Medical Setting: Pilot
Status: TERMINATED
Conditions: Suicide, Attempted
Interventions: DRUG: Intravenous ketamine|BEHAVIORAL: Cognitive training|BEHAVIORAL: Sham Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: External Beam Radiotherapy and Zevalin for Management of Indolent B-Cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, B-Cell
Interventions: OTHER: external beam radiotherapy plus 90-Y ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Disturbances in Patients With Psychotic Symptoms (AkuSleep)
Status: ENROLLING_BY_INVITATION
Conditions: Sleep Disturbance|Psychotic Disorders
Interventions: BEHAVIORAL: Modified CBT for insomnia|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Saxagliptin in Combination With Metformin IR Compared to Saxagliptin Monotherapy and to Metformin IR Monotherapy in Drug Naive Chinese Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic Control
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Saxagliptin 5 mg|DRUG: Placebo 5 mg for Saxagliptin|DRUG: Placebo 500 mg for metformin (with titration)|DRUG: Metformin 500 mg with titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duration of Physical Inactivity and Postprandial Lipid Metabolism
Status: RECRUITING
Conditions: Metabolism
Interventions: BEHAVIORAL: 4 hours of physical inactivity|BEHAVIORAL: 8 hours of physical inactivity|BEHAVIORAL: 12 hours of physical inactivity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lung Deposition of TRIMBOW® pMDI in Healthy Volunteers, Asthmatic and COPD Patients
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease|Asthma
Interventions: DRUG: Beclometasone dipropionate Formoterol Fumarate Glycopyrronium Bromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apixaban During Atrial Fibrillation Catheter Ablation: Comparison to Vitamin K Antagonist Therapy
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Vitamin K antagonist|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma
Status: RECRUITING
Conditions: Metastatic Renal Cell Carcinoma|Clear-cell Metastatic Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Drug Levels and Safety of Luspatercept (ACE-536) for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes in Chinese and Japanese Participants With Ring Sideroblasts Who Require Red Blood Cell Transfusions
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 24-Week Study to Evaluate the Safety and Efficacy of ADVAIR DISKUS® Inhaler 250/50mcg Plus SPIRIVA HANDIHALER® Inhaler Versus SPIRIVA HANDIHALER® Inhaler Plus Placebo DISKUS® Inhaler in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium Bromide|DRUG: Fluticasone Propionate/Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients With Moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan/HCTZ|DRUG: Irbesartan monotherapy|DRUG: HCTZ monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Mindful Community for People With ALS and Their Primary Caregivers
Status: RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Caregiver Burden
Interventions: BEHAVIORAL: Mindfulness|BEHAVIORAL: Mindful Learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of K-757 and K-833 in Overweight/Obese Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes Mellitus in Obese
Interventions: DRUG: K-757 and K-833|DRUG: Matching placebo to K-757 and K-833
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of SABR and L19-IL2 in Patients With Stage IV Lung Cancer (ImmunoSABR)
Status: WITHDRAWN
Conditions: NSCLC Stage IV|Limited Metastatic Disease
Interventions: DRUG: L19-IL2|RADIATION: SBRT|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase II Study of DCE-MRI-based Dose Escalation for Poor-prognosis and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Cisplatin|DRUG: Carboplatin|RADIATION: IMRT (Intensity-Modulated Radiation Therapy)|RADIATION: Boost Radiation to Hypoperfused Volumes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Photodynamic Therapy Versus Daylight Photodynamic Therapy for The Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: 5-Aminolevulinic Acid-Containing Product in Cutaneous Dose Form
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT