pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Ameliorating Effect of COVID-19 mRNA Vaccine in Individuals Immunized With Inactivated Vaccine
Status: UNKNOWN
Conditions: SARS-CoV-2 Acute Respiratory Disease
Interventions: BIOLOGICAL: SARS-Cov-2 mRNA vaccine immunization|BIOLOGICAL: Inactivated SARS-Cov-2 vaccine immunization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1/2 Study of KSQ-001EX, Autologous Tumor Infiltrating Lymphocytes Engineered to Inactivate the SOCS1 Gene, in Patients With Select Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Melanoma|Lung Neoplasms|Head and Neck Neoplasms
Interventions: DRUG: KSQ-001EX|DRUG: Interleukin-2|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Education on Breastfeeding
Status: COMPLETED
Conditions: Education|Mobile Messages|Breastfeeding Self-efficacy|Breastfeeding Attitude|Maternal Experience Satisfaction
Interventions: OTHER: Breastfeeding and Basic Maternal-Neonatal Care and mobile messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Initial Testing of the Diabeloop Algorithm in T1D Patients on Pump Therapy Over the Prandial Period and Physical Activity.
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Intra Ocular Pressure After Insertion of the LMA Supreme and LMA Proseal in Pediatric Patients
Status: UNKNOWN
Conditions: Intra Ocular Pressure
Interventions: DEVICE: I-gel|DEVICE: LMA Supreme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Purpose of This Study is to Determine Whether CerebroFlo™ EVD Catheter is Effective During the Treatment of IVH
Status: RECRUITING
Conditions: Intraventricular Hemorrhage|Subarachnoid Hemorrhage
Interventions: DEVICE: CerebroFlo™ EVD Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ONCOXIN in Patients With Breast Fibrocystic Disease
Status: COMPLETED
Conditions: Breast Fibrocystic Disease
Interventions: DIETARY_SUPPLEMENT: Oncoxin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of CelTx(TM) (Apligraf®) in the Treatment of Gingival Recession Requiring Root Coverage
Status: TERMINATED
Conditions: Gingival Recession
Interventions: DEVICE: CelTx|OTHER: Autologous sub-epithelial connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation Program Via Videoconference PAH - Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Arterial Hypertension|Cardiovascular Diseases|Respiratory Disease Nursing|Hypertension, Pulmonary|Pulmonary Hypertension
Interventions: OTHER: Aerobic and Resistance training with rehabilitation|OTHER: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeat Lumbar Puncture at 24 Versus 48 Hours After Traumatic Lumbar Puncture in Neonates
Status: COMPLETED
Conditions: Neonate|Meningitis|Spinal Puncture
Interventions: OTHER: 24 hours|OTHER: 48 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study Between Subcutaneous Tissue Closure Versus Drain in Obese Women Undergo Elective Cesarean Section
Status: COMPLETED
Conditions: Wound Infection
Interventions: PROCEDURE: Cesarean section|PROCEDURE: subcutanous sutures|DEVICE: subcutanous drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Anti-HIV Therapy on Treatment for Hepatitis C in HCV/HIV Infected Adults
Status: COMPLETED
Conditions: HIV Infections|Hepatitis C
Interventions: DRUG: Efavirenz|DRUG: Lamivudine|DRUG: Lopinavir/ritonavir|DRUG: Pegylated interferon alfa-2a|DRUG: Ribavirin|DRUG: Tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Antiviral Activity and Safety of Alovudine in Nucleoside-experienced HIV-infected Subjects Experiencing Virologic Failure
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Alovudine - low|DRUG: Alovudine - medium|DRUG: Alovudine - high|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Atorvastatin as an Anti-Inflammatory Agent in Non-Cystic Fibrosis Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter 12 Months Clinical Study to Evaluate Efficacy and Safety of Ranibizumab Alone or in Combination With Laser Photocoagulation vs. Laser Photocoagulation Alone in Proliferative Diabetic Retinopathy (PRIDE)
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy (PDR)
Interventions: DRUG: Ranibizumab 0.5 mg|PROCEDURE: Panretinal laser photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational, Prospective Evaluation of the Trifecta™ Valve
Status: COMPLETED
Conditions: Aortic Valve Insufficiency|Regurgitation, Aortic Valve|Aortic Valve Incompetence|Aortic Valve Stenosis
Interventions: DEVICE: Trifecta aortic heart valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab+ sEphB4 in Metastatic Urothelial Carcinoma
Status: RECRUITING
Conditions: Metastatic Urothelial Carcinoma
Interventions: DRUG: Pembrolizumab + sEphB4-HSA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil (MMF) Discontinuation From a Tacrolimus/MMF/Steroid Triple Regimen After Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil|DRUG: methylprednisolone and prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Auditory and Visual Cueing on Sensorimotor Recovery and Gait in Hemiplegia
Status: RECRUITING
Conditions: Hemiplegia
Interventions: OTHER: Rhtyhmical auditory stimulation and Visual cues (Experimental group)|OTHER: Rhtyhmical auditory stimulation (Control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interventions for Patients With Alzheimer's Disease and Dysphagia
Status: RECRUITING
Conditions: Dementia|Dysphagia|Alzheimer Disease
Interventions: DEVICE: Isometric tongue strengthening facilitated by Iowa Oral Performance Instrument (IOPI)|DEVICE: Biotene Oral Balance Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Tolerability and Efficacy Study of Cabaletta to Treat Oculopharyngeal Muscular Dystrophy (OPMD) Patients
Status: COMPLETED
Conditions: Oculopharyngeal Muscular Dystrophy
Interventions: DRUG: Cabaletta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Versus Proprioceptive Neuromuscular Facilitation on Postmastectomy Lymphedema
Status: COMPLETED
Conditions: Postmastectomy Lymphedema
Interventions: OTHER: virtual reality|OTHER: proprioceptive neuromuscular facilitation|OTHER: complete decogestive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cadonilimab (AK104) Plus Lenvatinib in Patients With Advanced Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer|Endometrial Adenocarcinoma
Interventions: DRUG: Cadonilimab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Building Evidence-Based Supports for Teens Via Technology
Status: UNKNOWN
Conditions: Depression
Interventions: BEHAVIORAL: PROJECT PERSONALITY|BEHAVIORAL: VR PERSONALITY PROJECT|BEHAVIORAL: SHARING FEELINGS PROGRAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AI-EBUS-Elastography for LN Staging
Status: COMPLETED
Conditions: Artificial Intelligence|Endobronchial Ultrasound|Elastography|NSCLC|Lung Cancer
Interventions: DEVICE: EBUS-Elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Developing a Smartphone App With Mindfulness Training for Teen Smoking Cessation
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: BEHAVIORAL: C2Q-Teen app|BEHAVIORAL: NCI's QuitSTART app|BEHAVIORAL: Written smoking cessation materials only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Post-prandial Effects of Extra Virgin Olive Oil on Endothelial Function in Adults at Risk for Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Extra Virgin Olive Oil|OTHER: Refined Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 4-aminopyridine Treatment for Nerve Injury
Status: SUSPENDED
Conditions: Nerve Injury|Prostate Cancer
Interventions: DRUG: 4-Aminopyridine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)
Status: COMPLETED
Conditions: COVID|COVID-19|SARS-CoV-2|SARS (Severe Acute Respiratory Syndrome)
Interventions: BIOLOGICAL: Hyperimmune immunoglobulin to SARS-CoV-2 (hIVIG)|OTHER: Placebo|DRUG: Remdesivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dietary Fiber-enriched Cereals on Glycemic Control and Secretion of Gut Hormones
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: dietary fiber-enriched cereal|OTHER: conventional cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot RCT on the Efficacy of TranS-C Intervention on Anxiety Symptoms
Status: UNKNOWN
Conditions: Anxiety
Interventions: BEHAVIORAL: Transdiagnostic Sleep and Circadian Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-surgical Alternatives to Treatment of Failed Medical Abortion
Status: TERMINATED
Conditions: Abortion Failure
Interventions: DRUG: Mifepristone|DRUG: Misoprostol|DRUG: Placebo mifepristone|DRUG: Placebo misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lifitegrast 5% on Tear Film Markers
Status: WITHDRAWN
Conditions: Dry Eye|Dry Eye Syndromes|Dry Eyes Chronic
Interventions: DRUG: Lifitegrast 5% Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Different Dietary Fat Sources on Blood Lipids and Other CVD Risk Factors
Status: UNKNOWN
Conditions: Dietary Modification
Interventions: OTHER: Coconut oil|OTHER: Butter|OTHER: Olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children
Status: COMPLETED
Conditions: The Efficacy of Inactivated EV71 Vaccine (KMB17) Against HFMD in Chinese Children and Infants
Interventions: BIOLOGICAL: 100U/0.5ml in 6-11 months old infants|BIOLOGICAL: 100U/0.5ml in 12-23 months old infants|BIOLOGICAL: 100U/0.5ml in 24-35 months old children|BIOLOGICAL: 100U/0.5ml in 36-71 months old children
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders
Status: COMPLETED
Conditions: Chronic Unexplained Nausea and Vomiting|Gastroparesis
Interventions: DEVICE: nVNS (gammaCore)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate The Safety And Efficacy Properties Of PF-00547659 In Patients With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: BIOLOGICAL: Single dose-group A|BIOLOGICAL: Single dose-group A|BIOLOGICAL: Multiple dose- Group B|BIOLOGICAL: Single dose-group A|BIOLOGICAL: Multiple dose- Group B|BIOLOGICAL: Single dose-group A|BIOLOGICAL: Single dose-group A|BIOLOGICAL: Single dose-group A|BIOLOGICAL: Single dose-group A|BIOLOGICAL: Multiple dose-Group B|BIOLOGICAL: Multiple dose- Group B|BIOLOGICAL: Multiple dose- Group B|BIOLOGICAL: Multiple dose- Group B|BIOLOGICAL: Multiple dose- Group B|BIOLOGICAL: Multiple dose-Group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Citicoline in Treatment of Neonates With Hypoxic Ischemic Encephalopathy
Status: RECRUITING
Conditions: Hypoxic Ischemic Encephalopathy of Newborn
Interventions: DRUG: Citicoline Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TACE Combined With Tislelizumab in Patients With Advanced Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Tislelizumab|COMBINATION_PRODUCT: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Endovenous 940 and 1470 Laser Ablation for Treating Great Saphenous Veins
Status: COMPLETED
Conditions: Varicose Veins|Insufficiency of Great Saphenous Vein
Interventions: PROCEDURE: Endovenous laser ablation (EVLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study on Safety and Immunogenicity of VPM1002 in Comparison to BCG in Healthy Volunteers in South Africa
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: VPM1002 live vaccine|BIOLOGICAL: commercially available live vaccine BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Out Come Study To Define Laboratory Parameters That Are Best Suited to Diagnose Functional Iron Deficiency
Status: COMPLETED
Conditions: Functional Iron Deficiency
Interventions: PROCEDURE: %-hypo (laboratory parameter, functional iron deficiency)|PROCEDURE: CHr (laboratory parameter, functional iron deficiency)|PROCEDURE: RET-HE (laboratory parameter, functional iron deficiency)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Dabigatran in Patients With Cirrhosis and Portal Vein Thrombosis
Status: UNKNOWN
Conditions: Liver Cirrhosis|Portal Vein Thrombosis
Interventions: DRUG: Dabigatran|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring Daily Grain Intake Study
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Control Refined Grain Diet|OTHER: Low Whole Grain Oat Diet|OTHER: High Whole Grain Oat Diet|OTHER: Low Whole Grain Wheat Diet|OTHER: High Whole Grain Wheat Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic Interactions Between Hydronidone and Entecavir Capsules in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Hydronidone
Interventions: DRUG: Hydronidone capsules& Entecavir capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EMD 521873 in Advanced Solid Tumors, MTD Finding
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: EMD 521873|BIOLOGICAL: EMD 521873|BIOLOGICAL: EMD 521873
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Repair of Acute Achilles Tendon Rupture With Assistance of Intraoperative Ultrasound
Status: COMPLETED
Conditions: Acute Rupture of Achilles Tendon
Interventions: OTHER: percutaneous repair with an intraoperative assisted ultrasound|OTHER: percutaneous repair without an intraoperative assisted ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combine Mirror Therapy and tDCS on CPSP
Status: COMPLETED
Conditions: Stroke|Pain
Interventions: BEHAVIORAL: mirror therapy|DEVICE: tDCS|BEHAVIORAL: sham mirror therapy|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vacc-4x + Lenalidomide vs. Vacc-4x +Placebo in HIV-1-infected Subjects on Antiretroviral Therapy (ART)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Lenalidomide|DRUG: Lenalidomide placebo|DRUG: Vacc-4X|DRUG: rhuGM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS)
Status: TERMINATED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Magrolimab|DRUG: Azacitidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib and Raltitrexed Versus Fruquintinib Monotherapy in Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Advanced Colorectal Carcinoma
Interventions: DRUG: Fruquintinib and raltitrexed|DRUG: Fruquintinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: World Digital Detox Program for Enhancing Youth and Family Well-being
Status: COMPLETED
Conditions: Psychological Well-Being|Adolescent Behavior|Family
Interventions: OTHER: World Digital Detox Family Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Pioglitazone in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ipragliflozin|DRUG: Placebo|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Risperidone to Augment SSRI Therapy in Patients With Treatment-resistant Depression
Status: COMPLETED
Conditions: Depressive Disorder|Depressive Disorder, Major|Depression
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prometa Pharmacotherapy for Methamphetamine Dependence
Status: COMPLETED
Conditions: Drug Abuse|Drug Dependence
Interventions: DRUG: Prometa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insomnia and Sleep Disturbances in Chronic Pain Patients - Relation to Physical Activity Level and Opioid Use
Status: UNKNOWN
Conditions: Chronic Pain|Insomnia|Exercise|Sleep|Sleep Disorder|Opioid Use
Interventions: DEVICE: Accelerometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Axetis Inert Coronary Stent System First In Man Clinical Investigation (AXETIS FIM)
Status: UNKNOWN
Conditions: Native Coronary Artery Stenosis
Interventions: DEVICE: Axetis Inert Coronary Stents
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Immunogenicity Phase IC Study of CryJ2 -DNA-LAMP Plasmid Vaccine for Assessment of Intradermal (ID) Route of Administration Using the Biojector 2000 Device
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: CryJ2-DNA-LAMP plasmid vaccine by intradermal injection|OTHER: Saline Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Saxagliptin in Combination With Dapagliflozin - Effects on Islet Cell Function
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus
Interventions: DRUG: Saxagliptin|DRUG: Placebo for Saxagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SC12267 (4SC-101) in Combination With Methotrexate in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SC12267 (4SC-101)|DRUG: Placebo|DRUG: Methotrexate|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Effect of Formulation on the Bioavailability of Ipatasertib in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: ipatasertib (Capsule)|DRUG: ipatasertib (Tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: rhNGF 20 µg/mL|DRUG: rhNGF 4 µg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MK-1029 in Participants With Persistent Asthma That Cannot Be Controlled With Montelukast (MK-1029-015)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MK-1029 150 mg|DRUG: MK-1029 Matching-image Placebo|DRUG: Montelukast 10 mg|DRUG: Albuterol/Salbutamol 90 mcg - 100 mcg per inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Anesthesia for Pediatric Cochlear Implant
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: DRUG: Lidocaine 1%/Epi 1:200000|OTHER: Na Cl 0.9%/Epi 1:200000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacological and Behavioral Treatments After Bariatric Surgery: Maintenance Treatment (Stage 2a)
Status: ENROLLING_BY_INVITATION
Conditions: Loss-of-Control Eating|Obesity/Overweight
Interventions: DRUG: Naltrexone and Bupropion (NB) medication|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)
Status: ACTIVE_NOT_RECRUITING
Conditions: Infections|Human Cathelicidin Antimicrobial Peptide (hCAP-18)
Interventions: DIETARY_SUPPLEMENT: vitamin D3|DRUG: omega-3 fatty acids (fish oil)|DIETARY_SUPPLEMENT: Vitamin D3 placebo|DIETARY_SUPPLEMENT: fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bevacizumab and Temozolomide Following Radiation and Chemotherapy for Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: Bevacizumab and Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D on Hormonal, Metabolic and Cardiovascular Risk Factors in Patients With Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: OTHER: Vitamin D3, 3200IU|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravenous Zotatifin in Adults With Mild or Moderate COVID-19
Status: COMPLETED
Conditions: Corona Virus Infection
Interventions: DRUG: Zotatifin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VITdAL@ICU - Correction of Vitamin D Deficiency in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness|Vitamin D Deficiency
Interventions: DRUG: Cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gait Analyses After Resurfacing Hip Arthroplasty Versus Metal on Metal Total Hip Arthroplasty, an Exploratory Study
Status: COMPLETED
Conditions: Difficulty Walking|Gait, Stumbling
Interventions: OTHER: Gait analysis on a trendmill
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Resistance Training Program and Cardiovascular Exercise in Increasing Muscle Mass in Adolescent and Young Adult Stem Cell Transplant Survivors
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: BEHAVIORAL: Exercise Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Safety/Efficacy of hUC Mesenchymal Stem Cells（19#iSCLife®-OA） Therapy for Patients With Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: Low dose mesenchymal stem cells|BIOLOGICAL: High dose mesenchymal stem cells|PROCEDURE: Intraarticular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PNEUMOCELL - Conjugated Pneumococcal Vaccination in Patients With Immunoglobulin G-deficiency
Status: COMPLETED
Conditions: IgG Deficiency
Interventions: BIOLOGICAL: Prevenar13
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficiency of γδ T Cell Against Breast Cancer(Her-, er-, and pr-)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: DC-CIK|BIOLOGICAL: γδ T Cell|BIOLOGICAL: Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Valvular Heart Disease
Interventions: PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: ERAS group|PROCEDURE: Conventional control group|PROCEDURE: ERAS group|PROCEDURE: Conventional control group|PROCEDURE: Conventional control group|PROCEDURE: Conventional control group|PROCEDURE: Conventional control group|PROCEDURE: Conventional control group|PROCEDURE: Conventional control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AJU-S56 in Dry Eye Syndrome Patients
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: (AJU-S56 5% and placebo)|DRUG: AJU-S56 5%|DRUG: Placebo(Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention Comparative Effectiveness for Adult Cognitive Training
Status: COMPLETED
Conditions: Cognitive Aging
Interventions: BEHAVIORAL: BrainHQ|BEHAVIORAL: Rise of Nations|BEHAVIORAL: IADL Training|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Melatonin and Oxygen Consumption and Choroidal Blood Flow
Status: COMPLETED
Conditions: Vasospastic Syndrome
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study of Whole Gland Salvage HDR Prostate Brachytherapy for Locally Recurrent Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer Recurrent
Interventions: RADIATION: HDR brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block Versus Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Surgeries
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: Quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
Status: RECRUITING
Conditions: HIV Associated Neurocognitive Disorder|HIV Dementia|HIV Encephalitis|Healthy
Interventions: DRUG: SV2A PET|DRUG: TSPO PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Purpose of This Study Was to Determine Whether or Not Functional Training Has Similar Effects on Muscular Strength, Flexibility, Agility, Speed and Anthropometric Measures in Basketball Players as Traditional Resistance Training
Status: COMPLETED
Conditions: Basketball|Exercise
Interventions: OTHER: Functional Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transbronchial Biopsies With Cryoprobe in Patients With Lung Transplantation.
Status: UNKNOWN
Conditions: Lung Transplant Rejection
Interventions: PROCEDURE: Biopsies CP|PROCEDURE: Biopsies FC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Therapy With MYOCET® (Doxorubicin HCL Liposome for Injection) in Participants With HER2-Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Liposomal doxorubicin hydrochloride|DRUG: Cyclophosphamide|DRUG: Trastuzumab|DRUG: Free doxorubicin hydrochloride|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Alogliptin|DRUG: Metformin|DRUG: Alogliptin Placebo|DRUG: Metformin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Murine CD19 CAR-T Therapy for Patients With Relapsed or Refractory CD19+ B-cell Hematological Malignancies
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Non-Hodgkin Lymphoma of Soft Tissue
Interventions: DRUG: Murine CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Two Dual PI3K/mTOR Inhibitors, PF-04691502 And PF-05212384 In Patients With Recurrent Endometrial Cancer
Status: TERMINATED
Conditions: Endometrial Neoplasms
Interventions: DRUG: PF-05212384|DRUG: PF-05212384|DRUG: PF-05212384
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breast Milk vs Sucrose in Relieving Procedural Pain in Preterm Neonates During Blood Draw by Automated Heel Lance
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Breast Human Milk|OTHER: 24 % Sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Regimens of PegIntron Plus Ribavirin in Previously Untreated Chronic Hepatitis C, Genotype 2 or 3 (Study P03548)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: peginterferon alfa-2b (SCH 54031)|BIOLOGICAL: peginterferon alfa-2b (SCH 54031)|BIOLOGICAL: peginterferon alfa-2b (SCH 54031)|DRUG: ribavirin (SCH 18908)|DRUG: ribavirin (SCH 18908)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Clinical Trial of VLA1553 in Healthy Children Aged 1 to 11 Years
Status: ACTIVE_NOT_RECRUITING
Conditions: Chikungunya Virus Infection
Interventions: BIOLOGICAL: VLA1553 full dose|BIOLOGICAL: VLA1553 half dose|BIOLOGICAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Beta Adrenergic Antagonist for the Healing of Chronic DFU
Status: COMPLETED
Conditions: Chronic Diabetic Foot Ulcers|Diabetic Neuropathic Ulcers|Non Healing Wound
Interventions: DRUG: Timolol|DRUG: Non biologically active gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)
Status: UNKNOWN
Conditions: Obesity|Insulin Resistance|Insulin Sensitivity|Beta-Cell Dysfunction|Prediabetes
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d)|DIETARY_SUPPLEMENT: High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Physical Therapy Interventions Relative to Dental Treatment in Individuals With Bruxism
Status: UNKNOWN
Conditions: Bruxism
Interventions: OTHER: Massage and stretching exercises|OTHER: Relaxation and imagination therapies|OTHER: Dental treatment|OTHER: Massage, exercises, relaxation and imagination therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of an Oral Contraceptive (OC) Preparation Versus Placebo for 6 Treatment Cycles in Women With Moderate Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: YAZ (DRSP 3 mg/EE 0.02 mg, BAY86-5300)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis
Status: COMPLETED
Conditions: Herpes Labialis
Interventions: DRUG: ME-609|DRUG: acyclovir in ME-609 vehicle|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Comparing the Dulaglutide Pen and the Semaglutide Pen
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Dulaglutide Pen|DRUG: Semaglutide Pen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: OTHER: Neurological and neuropsychological consultation, MRI|OTHER: Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigating the Effectiveness of a Seasonal Influenza Vaccination Promotion Campaign for Members of a Non-Profit, Community-Based Health Insurance Plan: 2018-2019
Status: UNKNOWN
Conditions: Influenza, Vaccination
Interventions: BEHAVIORAL: Messaging|BEHAVIORAL: Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Two Nutrition Interventions in Young Children in El Salvador
Status: UNKNOWN
Conditions: Micronutrient Deficiency
Interventions: DIETARY_SUPPLEMENT: 21 micronutrient-fortified supplement|DIETARY_SUPPLEMENT: Cereal Fortificado (Fortified Cereal)|DIETARY_SUPPLEMENT: Ferrous sulphate|DIETARY_SUPPLEMENT: Vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CPAP Versus Bilevel Pressure Support Ventilation in Cardiogenic Pulmonary Edema
Status: COMPLETED
Conditions: Severe Acute Cardiogenic Pulmonary Edema
Interventions: DEVICE: Boussignac CPAP - bilevel ventilation support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patients
Status: COMPLETED
Conditions: Sickle Cell Disease|Pharmacokinetics
Interventions: DRUG: L-glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DEVICE: PFC Sigma RP TC3 Revision knee system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Treatment of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Skin
Status: TERMINATED
Conditions: Metastatic Head-and-neck Squamous-cell Carcinoma
Interventions: DRUG: TH-4000 (Tarloxotinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise on Cognition in Older Adults At-risk for Diabetes: A Feasibility Pilot Study
Status: COMPLETED
Conditions: Cognitive Impairment
Interventions: BEHAVIORAL: Resistance Training|BEHAVIORAL: Balance and Tone Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Peripheral Blocks Under Ultrasound Control With and Without Electrical Nerve Stimulation
Status: COMPLETED
Conditions: Nerve Block|Efficiency|Sciatic Nerve|Ultrasonography
Interventions: OTHER: sciatic nerve blockade under ultrasound control with a peripheral nerve stimulator|OTHER: sciatic nerve blockade under ultrasound control without a peripheral nerve stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Impact of Clinical Pharmacist-Led Intervention on Management of Diabetic Hypertensive Patients in Eastern Nepal
Status: RECRUITING
Conditions: Type 2 Diabetes|Hypertension
Interventions: OTHER: Clinical Pharmacist-Led Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of MK0663 in Patients With Chronic Low Back Pain (0663-806)(COMPLETED)
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: DRUG: MK0663, etoricoxib / Duration of Treatment: 4 weeks|DRUG: Comparator: diclofenac / Duration of Treatment: 4 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Resistance to Participant-Supported Reaching on Workspace of the Hand in Severe Chronic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Impairment-based robotic intervention for reaching function
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Almonds on Insulin Sensitivity in Prediabetes
Status: COMPLETED
Conditions: PreDiabetes
Interventions: OTHER: 1.5 oz of whole, natural almonds|OTHER: Low-fat, high refined starches/sugars
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Study of Icotinib With Concurrent Radiotherapy in Elderly Patients With Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: Icotinib|RADIATION: Thoracic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastrazole Plus GnRH-agonist in the Treatment of Endometriosis Recurrence
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: anastrazole|DRUG: GnRH analog alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil 100 mg Tablets Relative to Viagra 100 mg Tablets
Status: NOT_YET_RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: Sildenafill-Test product|DRUG: Sildenafill-Reference product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Cerebral Toxoplasmosis in HIV/AIDS
Status: COMPLETED
Conditions: Toxoplasmic Encephalitis|AIDS
Interventions: DRUG: TMX-SMX (Bactrim(R))|DRUG: Pyrimethamine plus Sulfadiazine plus leucoverin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of add-on Dapsone Versus add-on Methotrexate in Patients With Bullous Pemphigoid
Status: RECRUITING
Conditions: Bullous Pemphigoid
Interventions: DRUG: Prednisolone|DRUG: Dapsone|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT