pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Hyperpolarized 13C Pyruvate MRI for Early Immune Evaluation in Cervical Cancer Patients at Baseline and CCRT Therapy
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Hyperpolarized 13C Pyruvate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nivolumab With Ipilimumab in Subjects With Neuroendocrine Tumors
Status: TERMINATED
Conditions: Neuroendocrine Tumors|Carcinoid Tumor
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Safety and Efficacy of MesoCellA-Ortho Tissue-Engineered Advanced Therapy Product in Patients With Osteoarthrosis and Civilisation Diseases
Status: COMPLETED
Conditions: Osteoarthritis of Knee
Interventions: DRUG: MesoCellA-Ortho administration|DRUG: HA administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Efficacy of Proellex® (Telapristone Acetate) Administered Vaginally in the Treatment of Premenopausal Women With Uterine Fibroids Who Have Completed ZPV-200
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: Proellex 12 mg|DRUG: Proellex 24 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib Cream in Participants With Facial and/or Neck Atopic Dermatitis Involvement
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Ruxolitinib cream|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Comparing Nebivolol and Atenolol and Its Effects With Exercise in Patients With Mild to Moderate Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nebivolol and Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3b, Single-Center, Open-label Study to Assess the Immunogenicity and Safety of Novartis Meningococcal B Recombinant Vaccine When Administered at a 0, 2-Month Schedule in Healthy At-Risk Adults Aged 18 to 65 Years Inclusive.
Status: COMPLETED
Conditions: Prevention of the Meningococcal Disease
Interventions: BIOLOGICAL: rMenB+OMV NZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PET/MRI in the Diagnosis of Pediatric Chronic Pain
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Pain|Pediatric Disorder|Neuropathic Pain|Nociceptive Pain
Interventions: DRUG: [18F]FTC-146
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Suprasorb® A + Ag in the Treatment of Wounds at Risk of Infection and Infected Wounds
Status: COMPLETED
Conditions: Pressure Ulcer|Arterial Ulcers|Venous Leg Ulcer|Diabetic Ulcers|Surgical Wound|Skin Graft
Interventions: DEVICE: Suprasorb® A + Ag wound dressing and rope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravenous Versus Topical Administration of Low Dose Epinephrine Plus Combined Administration of Intravenous and Topical Tranexamic Acid (TXA)for Primary Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Blood Loss
Interventions: DRUG: Tranexamic acid (TXA)|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of SGLT-2 Inhibitors in Patients With Heart Failure and Diabetes
Status: COMPLETED
Conditions: Heart Failure|Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine as Adjuvant for FNB in TKA
Status: COMPLETED
Conditions: Nerve Block|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|PROCEDURE: ultrasound-guided femoral nerve block|DEVICE: intravenous patient-controlled analgesia pump with morphine|PROCEDURE: Continuous femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of RAS(ON) Inhibitor Combinations in Patients With Advanced RAS-mutated NSCLC
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer, NSCLC|KRAS, NRAS, HRAS-mutated NSCLC|KRAS G12C-mutated Solid Tumors, Lung Cancer|Lung Cancer Stage IV, Advanced Solid Tumor, Cancer
Interventions: DRUG: RMC-6291|DRUG: RMC-6236|DRUG: Pembrolizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antiplatelet Therapy for AIS Patients With Thrombocytopenia
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Thrombocytopenia
Interventions: DRUG: aspirin, clopidogrel, cilostazol, and dipyridamole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Activated Recombinant Human Factor VII in Cirrhotic Patients Undergoing Partial Hepatectomy
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Cirrhosis
Interventions: DRUG: activated recombinant human factor VII|DRUG: activated recombinant human factor VII|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke|Middle Cerebral Artery Infarction
Interventions: PROCEDURE: Intercerebral implantation of Autulogous Stem Cells|DRUG: convention therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
Status: COMPLETED
Conditions: Peripheral Neuropathy|Breast Cancer
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open Label Comparative Study Of De Novo Renal Allograft Recipients Receiving CSA + MMF + Corticosteroids Versus CSA + Rapamune + Corticosteroids
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: CsA+Rapamune+CS|DRUG: CsA+MMF+CS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Near-infrared Spectroscopy (NIRS) Versus Invasive Licox Intracranial Pressure
Status: WITHDRAWN
Conditions: Brain Injuries
Interventions: DEVICE: Licox® Brain Tissue Oxygen Monitoring System|DEVICE: Near-infrared spectroscopy (NIRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients
Status: RECRUITING
Conditions: Anal Basaloid Squamous Cell Carcinoma|Anal Canal Cloacogenic Carcinoma|Metastatic Anal Squamous Cell Carcinoma|Recurrent Anal Squamous Cell Carcinoma|Stage III Anal Cancer AJCC v8|Stage IV Anal Cancer AJCC v8|Unresectable Anal Squamous Cell Carcinoma
Interventions: DRUG: Carboplatin|BIOLOGICAL: Nivolumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of TAEST16001 in Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: BIOLOGICAL: NY-ESO-1(TCR Affinity Enhancing Specific T cell Therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Volunteer
Interventions: BIOLOGICAL: Ad4-Env145NFL|BIOLOGICAL: Ad4-Env150KN|BIOLOGICAL: VRC-HIVRGP096-00-VP (Trimer 4571) with alum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cardio-visual Stimulation in Augmented Reality for Pain Reduction
Status: COMPLETED
Conditions: Regional Pain Syndrome|Chronic Pain Syndrome
Interventions: DEVICE: HEART|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Testing in Predicting Tumor Response in Patients With Stage I-III HER2 Negative Invasive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Invasive Breast Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Conventional Surgery|OTHER: Genetic Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Maintenance of Effect of Duloxetine in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sinus Floor Elevation Using Separately Two Different Xenografts - A Prospective Randomized Clinical Trial
Status: UNKNOWN
Conditions: Posterior Maxilla Edentulous Patients With Insufficient Alveolar Bone Height
Interventions: DEVICE: Alpha-Bio's GRAFT Natural Bovine Bone|DEVICE: Bio-Oss xenograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction at Altitude
Status: WITHDRAWN
Conditions: Hypoxic Pulmonary Vasoconstriction
Interventions: DRUG: iloprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Dexamethasone in Prevention of the Second Phase or a Biphasic Reaction of Anaphylaxis
Status: RECRUITING
Conditions: Anaphylaxis
Interventions: DRUG: Dexamethasone Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Side-to-end Versus End-to-end Colorectal Anastomosis in Non-emergent Sigmoid and Rectal Cancers: Randomized Controlled Clinical Trial
Status: COMPLETED
Conditions: Gastrointestinal Neoplasms
Interventions: PROCEDURE: openSide to end colorectal anastomosis .|PROCEDURE: open end end to end stapler anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Parent-mediated Intervention With PACT on Children With ASD
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Preschool Autism Communication Therapy (PACT)|OTHER: Treatment As Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation
Status: NOT_YET_RECRUITING
Conditions: Non Squamous Non Small Cell Lung Cancer|EGFR Positive Non-small Cell Lung Cancer
Interventions: DRUG: Toripalimab plus Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fexofenadine HCL - Pseudoephedrine HCL Combination Versus Allegra in Patients With Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Rhinitis Seasonal
Interventions: DRUG: fexofenadine HCL (M016455)|DRUG: pseudoephedrine|DRUG: fexofenadine HCL matching placebo|DRUG: pseudoephedrine matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Aldurazyme® (Laronidase) Treatment on Lactation in Female Patients With Mucopolysaccharidosis I (MPS I) and Their Breastfed Infants
Status: TERMINATED
Conditions: Mucopolysaccharidosis I|Hurler's Syndrome|Hurler-Scheie Syndrome|Scheie
Interventions: BIOLOGICAL: Laronidase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer Presented and Physical Exercises to Maintain Cognitive Function and Emotional Health in Older Adults
Status: COMPLETED
Conditions: Cognitive Function|Depression in Old Age
Interventions: BEHAVIORAL: Physical exercise (PE) training and computer-based brain (CBB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multiple Ascending Dose, Phase 1b Study of YH35324 in Atopic Healthy Subjects or Subjects With Allergic Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Atopic Healthy Subjects|Adult Subjects With Allergic Diseases
Interventions: DRUG: YH35324|DRUG: Placebo|DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Pharmacodynamic Study of Bevacivumab and Pazopanib in Renal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Bevacizumab|DRUG: Pazopanib 2 week|DRUG: Pazopanib 3 week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hypothyroidism in Pregnancy and Neuropsychological Development in Children
Status: NOT_YET_RECRUITING
Conditions: Thyroid Dysfunction|Pregnancy Related|Language Development
Interventions: DIAGNOSTIC_TEST: Griffiths Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial of Efficacy and Safety of Oral Drug in Adult Patients With COVID-19
Status: UNKNOWN
Conditions: COVID-19|Mechanical Ventilation Complication|COVID-19 Acute Respiratory Distress Syndrome
Interventions: DRUG: WP1122
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Levonorgestrel 90 mg/Ethinyl Estradiol 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways
Status: UNKNOWN
Conditions: Sedative, Hypnotic, or Anxiolytic Withdrawal|Airway Control
Interventions: DEVICE: Respiratory Humidification Treatment Device, AIRVO 2 PT101AZ, Fisher & Paykel Healthcare, Inc.|DEVICE: Mask ventilation|DRUG: Midazolam(T group)|DRUG: Sufentani(T group)|DRUG: Propofol(T group)|DRUG: Rocuronium(T group)|DRUG: Drug use target(T group)|DRUG: Sufentanil(C group)|DRUG: Midazolam(C group)|DRUG: Propofol|DRUG: Tetracaine(C group)|DRUG: Drug use target
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a New Viscoelastic for Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Vitrax II|DEVICE: Viscoat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperthermia and High Dose Rate Radiation Therapy in Treating Patients With Recurrent Prostate Cancer After Radiation
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Prostate Carcinoma
Interventions: RADIATION: High-Dose Rate Brachytherapy|PROCEDURE: Hyperthermia Treatment|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive
Status: NOT_YET_RECRUITING
Conditions: Asthma|Mild Asthma
Interventions: DRUG: Salbutamol HFA-152a|DRUG: Salbutamol HFA-134a|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pain Relief After PrimaryTKA
Status: ENROLLING_BY_INVITATION
Conditions: Pain, Postoperative
Interventions: DRUG: Zynrelef (Bupivacaine 60 MG / Meloxicam 1.8 MG) Per 2.3 ML Extended Release Solution|DRUG: Bupivacaine HCl 0.5% Injectable Solution|PROCEDURE: primary total knee replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Routine Use of SSRI's at the Initiation of End-stage Renal Disease Treatment (RoSIE)
Status: TERMINATED
Conditions: End Stage Renal Disease
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pyrotinib Maleate Combined With ARX788 Neoadjuvant Treatment in Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: Next-generation Site-specific human epidermal growth factor receptor 2 (HER2)-targeting Antibody-drug Conjugate (ARX788)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplementation and Endurance Performance in Cyclists and Masters Runners
Status: COMPLETED
Conditions: Viral Upper Respiratory Tract Infection|Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: Probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Fecal Microbiota Transplantation (FMT) in the Treatment of Pouchitis
Status: COMPLETED
Conditions: Pouchitis|Ulcerative Colitis
Interventions: BIOLOGICAL: Fecal microbiota transplantation|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of St. John's Wort and Olive Oils on the Postoperative Complications
Status: COMPLETED
Conditions: Impacted Third Molar Tooth
Interventions: DRUG: Chlorhexidine Gluconate 0.12 % Mouthwash + benzydamine hydrochloride|PROCEDURE: St. John's wort oil|PROCEDURE: Virgin olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Sacral Neuromodulation for Treatment of Refractory Overactive Bladder (OAB)
Status: UNKNOWN
Conditions: Refractory Overactive Bladder
Interventions: DEVICE: PINS SNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modafinil in Cancer Related Fatigue
Status: COMPLETED
Conditions: Cancer Related Fatigue|Quality of Life
Interventions: DRUG: Modafinil|DRUG: Pyridoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fasting Study of Olanzapine Tablets 5 mg and Zyprexa® Tablets 5 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Olanzapine Tablets 5 mg|DRUG: Zyprexa® Tablets 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Characterization in 18F-FDG PET-CT of Brain and Lung Lesions in Subjects With a History of Severe COVID-19
Status: COMPLETED
Conditions: Covid-19
Interventions: DEVICE: 18F-FDG PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Comparing Premarin® Vaginal Cream Versus Premarin® Oral Tablets in Atrophic Vaginitis
Status: COMPLETED
Conditions: Atrophic Vaginitis
Interventions: DRUG: Premarin® Vaginal Cream|DRUG: Premarin® oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Open Label Study Investigating Safety and Efficacy of NPL2009 50 mg - 150 mg on Prepulse Inhibition Tests and Continuous Performance Tasks, Adults With Fragile X Syndrome
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: NPL-2009
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Online Brief Positive Cognitive Behavior Therapy Compared to Traditional Cognitive Behavior Therapy
Status: COMPLETED
Conditions: Emotional Distress|Well-Being, Psychological|Performance
Interventions: BEHAVIORAL: Positive Cognitive Behavioral Therapy|BEHAVIORAL: Traditional Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Angiotensin-converting Enzyme Inhibitors and Early Sickle Cell Renal Disease in Children
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: DRUG: Enalapril|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-utility of Ambulatory Surgery in the Management of Endometrial Cancer(AMBU-ENDO)
Status: COMPLETED
Conditions: Endometrial Cancer Stage I|Endometrial Cancer Stage II
Interventions: PROCEDURE: ambulatory surgery|PROCEDURE: standard surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EXtremely Early-onset Type 1 Diabetes EXtremely Early-onset Type 1 Diabetes (A Musketeers' Memorandum Study)
Status: RECRUITING
Conditions: Type1 Diabetes Mellitus
Interventions: DIAGNOSTIC_TEST: Beta Cell Loss and Immune Function|OTHER: Immune Function with RNAseq
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Nodular Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: PEP005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Stage I Lung Cancer AJCC v8|Stage IA1 Lung Cancer AJCC v8|Stage IA2 Lung Cancer AJCC v8|Stage IA3 Lung Cancer AJCC v8|Stage IB Lung Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8
Interventions: OTHER: Best Practice|OTHER: Informational Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Achieving Nutritional Adequacy Of Vitamins E and K With An Egg/Plant-Based Food Pairing - Study 2
Status: ACTIVE_NOT_RECRUITING
Conditions: Nutritional Requirements
Interventions: OTHER: Zero hard-boiled egg|OTHER: Two egg whites|OTHER: Two hard-boiled eggs|OTHER: Vegetable oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of CD276 Targeted Autologous Chimeric Antigen Receptor T Cell Infusion in Patients With CD276 Positive Advanced Solid Tumor
Status: UNKNOWN
Conditions: Osteosarcoma|Neuroblastoma|Gastric Cancer|Lung Cancer
Interventions: DRUG: Targeting CD276 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Oral Ferric Iron To Treat Iron Deficiency Anaemia in Quiescent Crohn's Disease (AEGIS-2)
Status: COMPLETED
Conditions: Iron Deficiency Anaemia|Inflammatory Bowel Disease|Crohn's Disease
Interventions: DRUG: ST10|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Matrix Metalloproteinase 14, Neopterin, and Orosomucoid 1 Levels in PPROM
Status: UNKNOWN
Conditions: Preterm Premature Rupture of Membranes
Interventions: DIAGNOSTIC_TEST: matrix metalloproteinase 14, neopterin, and orosomucoid 1 measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open Label Phase II Study of First-Line Maintenance Enzalutamide Following Docetaxel Plus Androgen-Deprivation Therapy in Patients With Previously-Untreated, Metastatic, Castration-Naive Prostatic Adenocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Prostatic Adenocarcinoma
Interventions: DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Jarvik 2000 Left Ventricular Assist System With Post-Auricular Connector--Destination Therapy Study
Status: RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: Jarvik 2000 VAS|DEVICE: HeartMate II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secondary Cytoreductive Surgery (CRS) in Patients With Relapsed Ovarian Cancer Who Have Progressed on PARP Inhibitor Maintenance
Status: RECRUITING
Conditions: Ovarian Cancer|Drug Related Neoplasm/Cancer
Interventions: PROCEDURE: secondary cytoreductive surgery|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Feasibility of Time-restricted Eating on Cardiometabolic Health in Adults With Overweight/Obesity
Status: COMPLETED
Conditions: Time Restricted Feeding|Obesity, Abdominal|Cardiometabolic Syndrome
Interventions: BEHAVIORAL: Early time-restricted eating|BEHAVIORAL: Late time-restricted eating|BEHAVIORAL: Self-selected time-restricted eating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiographic Bone Volume Alteration After Jaw Cyst Enucleation With Different Bone Grafts
Status: RECRUITING
Conditions: Jaw Cysts
Interventions: PROCEDURE: Collagen sponge|PROCEDURE: GBR|PROCEDURE: CS/GBR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tanezumab In Osteoarthritis Of The Hip Or Knee
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: tanezumab 10 mg|BIOLOGICAL: tanezumab 5 mg|DRUG: oxycodone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery
Status: COMPLETED
Conditions: Aortic Diseases|Abdominal|Aneurysm|Surgery
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects With Cognitive Impairment
Status: COMPLETED
Conditions: Cognitive Impairment, Mild
Interventions: DIETARY_SUPPLEMENT: Andrographis and Withania|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial.
Status: UNKNOWN
Conditions: Success of Inferior Alveolar Nerve Block
Interventions: DRUG: Magnesium sulfate|DRUG: Mepivacaine-Levonordefrin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Treatment With RP for Newly-diagnosed mPCa
Status: RECRUITING
Conditions: Prostatic Neoplasms|Neoplasm Metastasis
Interventions: PROCEDURE: Radical Prostatectomy (RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Bone Marrow Stem Cell Therapy for PSP, a Rare Form of Parkinsonism
Status: UNKNOWN
Conditions: Progressive Supranuclear Palsy
Interventions: BIOLOGICAL: stem cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer
Status: RECRUITING
Conditions: Cervical Carcinoma|Adenocarcinoma|Adenosquamous Carcinoma
Interventions: OTHER: Standard treatment: Control arm|PROCEDURE: Experimental arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Care in Multiple Clinics Versus Care in a Cardiac, Diabetes and Kidney Care Clinic
Status: COMPLETED
Conditions: Kidney Diseases|Heart Diseases|Diabetes Mellitus
Interventions: PROCEDURE: The Combined Cardiac Kidney Diabetes Care Clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Change of Head and Neck Position on Cricothyroid Membrane Localization and Membrane Height in Parturient Patients
Status: COMPLETED
Conditions: Airway Complication of Anesthesia
Interventions: DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Neuro-myo-electrical Stimulation on Insulin Sensitivity in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DEVICE: acute muscle exercise by NMES|DEVICE: daily workout sequence with NMES in one week|OTHER: rest situation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate and Compare Injections of Autologous Dermal and Epidermal Cells Into the Balding Scalp of Subjects With Hair Loss
Status: COMPLETED
Conditions: Androgenetic Alopecia|Male Pattern Baldness|Female Pattern Baldness
Interventions: BIOLOGICAL: Autologous cultured dermal and epidermal cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptation and Evaluation of the KEEP Model
Status: ENROLLING_BY_INVITATION
Conditions: Depression, Anxiety|Post Traumatic Stress Disorder|Suicide and Self-harm|Externalizing Behavior
Interventions: BEHAVIORAL: KEEP|BEHAVIORAL: Non-Affinity KEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Sterile Kinesio Tape on Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Postoperative Pain|Edema
Interventions: OTHER: sterile kinesio taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity
Status: TERMINATED
Conditions: Pediatric Obesity|Insulin Resistance|Impaired Glucose Tolerance|Cardiovascular Disease
Interventions: DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UARK 2015-03 A Phase II Trial of a Novel Proteasome/IMiD Combination
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Therapeutic Conventional Surgery|OTHER: Uniformly-labeled [13C]glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lateral Sagittal vs Costoclavicular Approach for Ultrasound-Guided Infraclavicular Block
Status: COMPLETED
Conditions: Anesthesia, Local|Nerve Block|Brachial Plexus Block
Interventions: PROCEDURE: Lateral Sagittal Approach|PROCEDURE: Costoclavicular Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Different Oral Thin Film (S)-Ketamine Formulations for Sublingual Administration in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: OTF 1|DRUG: OTF 2|DRUG: OTF 3|DRUG: OTF 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combined VCST With Phacoemulsification Versus Phacoemulsification in Primary Angle Closure Glaucoma
Status: COMPLETED
Conditions: Narrow-Angle Glaucoma
Interventions: PROCEDURE: Arm 1 : VCST-phaco group , Arm 2 : phaco group.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotic Supplementation on Cognitive and Emotional Functions in Healthy Elderly Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus and Bifidobacterium lactis|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Different General Anesthesia Methods on Immune Responses in Patients Undergoing Surgery for Tongue Cancer
Status: UNKNOWN
Conditions: Tongue Cancer
Interventions: PROCEDURE: intravenous anesthesia|PROCEDURE: combined intravenous-inhalational anesthesia|PROCEDURE: inhalational anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
Status: UNKNOWN
Conditions: Peptic Ulcer Hemorrhage|Peptic Ulcer, Acute With Hemorrhage|Peptic Ulcer|Proton Pump Inhibitor Overdose
Interventions: DRUG: intermittent (40mg as a bolus injection daily for 72hours)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED)
Status: COMPLETED
Conditions: Limbal Stem Cell Deficiency (LSCD)
Interventions: BIOLOGICAL: Amniotic Membrane Extract Eye Drop (AMEED)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Amiodarone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD
Status: NOT_YET_RECRUITING
Conditions: Cerebral Small Vessel Diseases|Stroke
Interventions: DRUG: Amlodipine folic acid 5.8mg+intensive antihypertensive therapy|DRUG: Amlodipine folic acid 5.8mg+standard antihypertensive therapy|DRUG: Amlodipine+intensive antihypertensive therapy|DRUG: Amlodipine+standard antihypertensive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Sacituzumab Govitecan (IMMU-132) in Patients With Recurrent or Persistent Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Sacituzumab govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Knee Injection RCT
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DRUG: Ketorolac Tromethamine Injection|DRUG: Methylprednisolone Acetate Injection|DRUG: Hylan G-F 20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending And Multiple Ascending Dose Study of RO5271983 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Placebo - MAD|DRUG: Placebo - SAD|DRUG: RO5271983 - MAD|DRUG: RO5271983 - SAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection
Status: TERMINATED
Conditions: Influenza A
Interventions: DRUG: Pimodivir 600 mg|DRUG: Placebo|OTHER: SOC Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of RWJ-445380 Cathepsin-S Inhibitor in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: RWJ-445380 100 mg|DRUG: RWJ-445380 200 mg|DRUG: RWJ-445380 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition
Status: WITHDRAWN
Conditions: Diarrhea, Malnutrition
Interventions: DRUG: alanyl-glutamine|DRUG: glycine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial
Status: COMPLETED
Conditions: Anal Canal Squamous Cell Carcinoma|Stage I Anal Cancer AJCC v8|Stage II Anal Cancer AJCC v8|Stage IIA Anal Cancer AJCC v8|Stage IIB Anal Cancer AJCC v8|Stage III Anal Cancer AJCC v8|Stage IIIA Anal Cancer AJCC v8|Stage IIIB Anal Cancer AJCC v8|Stage IIIC Anal Cancer AJCC v8
Interventions: DRUG: Cisplatin|DRUG: Fluorouracil|RADIATION: Linear Energy Transfer-Optimized Intensity Modulated Proton Therapy|PROCEDURE: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Efficacy And Safety Of a Novel Niclosamide Suspension Formulation For COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Niclosamide suspension|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients
Status: COMPLETED
Conditions: Serious Mental Illness|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Cardiovascular Disease|Major Depressive Disorder|Psychosis NOS
Interventions: DRUG: Simvastatin|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation
Status: COMPLETED
Conditions: Sedation in Intensive Care
Interventions: DRUG: HSK3486|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CIFASD 5 tDCS and Cognitive Training
Status: RECRUITING
Conditions: Fetal Alcohol Spectrum Disorders
Interventions: DEVICE: Active tDCS|BEHAVIORAL: Cognitive Training|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between 24-hour IOP Pattern and the 24-hour Blood Pressure Pattern in Patients With POAG
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Normal Tension Glaucoma
Interventions: DEVICE: Sensimed Triggerfish®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Multibending vs Conventional Endoscope for Direct Peroral Cholangioscopy
Status: UNKNOWN
Conditions: Common Bile Duct Calculi|Biliary Tract Cancer|Biliary Stricture|Bile Duct Diseases
Interventions: DEVICE: ultra-slim upper endoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Can the SurgInfoBot Improve the Consent Process for Endoscopy? A Randomised Controlled Trial
Status: UNKNOWN
Conditions: Gastro-Intestinal Disorder
Interventions: OTHER: Access to an automated conversational agent (SurgInfoBot)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Blood Flow Restriction Exercise Study
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Strength testing|BEHAVIORAL: Short Physical Performance Battery (SPPB)|BEHAVIORAL: Six-minute walk (SMW)|BEHAVIORAL: Numerical pain scale|BEHAVIORAL: Self-assessed function|PROCEDURE: Muscle biopsies|DEVICE: Determination of 1 Repetition Maximum (1-RM)|DEVICE: Blood flow restriction exercise|BEHAVIORAL: Borg CR10 scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pilot Study of DRibble Vaccine for Prostate Cancer Patients
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: DRibble Vaccine|BIOLOGICAL: HPV Vaccinations|DRUG: Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Uremic Pruritus|Chronic Kidney Disease-associated Pruritus|Hemodialysis|End-stage Renal Disease|Renal Replacement Therapy|ESRD
Interventions: DRUG: Fexofenadine|DRUG: Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplant
Interventions: OTHER: Cardio-oncology program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE