pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Rituximab Therapy for Patients on Kidney Transplant Waiting List With Positive Donor Specific Crossmatch to Living Donor
Status: WITHDRAWN
Conditions: Kidney Insufficiency
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Emergence Deliruim; Cerebral Palsy
Interventions: DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Proactive Reduction of Outpatient Malpractice: Increasing Safety, Efficiency, and Satisfaction
Status: UNKNOWN
Conditions: Medical Malpractice|Patient Safety
Interventions: OTHER: Training and in-office coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adherence to HIV Therapy in Heroin Addicts: Oral vs XR-NTX
Status: COMPLETED
Conditions: HIV|Substance Abuse|HIV Infections
Interventions: DRUG: Oral Naltrexone|DRUG: Naltrexone Implant|BEHAVIORAL: Group Drug Counseling Manual Driven
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy in Treating Patients With Ovarian Cancer or Primary Peritoneal Cancer in Remission Following Surgery and Chemotherapy
Status: UNKNOWN
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: RADIATION: yttrium Y 90 monoclonal antibody HMFG1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Rituximab Combined With Corticosteroids or Rituximab Monotherapy in the Treatment of Primary Membranous Nephropathy
Status: RECRUITING
Conditions: Primary Membranous Nephropathy
Interventions: DRUG: rituximab combined with corticosteroids|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Zhiwang Decoction Combined With Methotrexate in the Treatment of Early Rheumatoid Arthritis
Status: RECRUITING
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: Modified Zhiwang Decoction Combined with methotrexate|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Lutropin alfa|DRUG: Follitropin alfa and Lutropin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for the Treatment of Recurrent Urinary Tract Infections
Status: COMPLETED
Conditions: Recurrent Urinary Tract Infection
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Electrical Stimulation With Functional Task Training on Balance and Motor Abilities in Children With Diplegia
Status: COMPLETED
Conditions: Cerebral Palsy Spastic Diplegia
Interventions: DEVICE: functional electrical stimulation|OTHER: functional task training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vaper to Vaper: A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping
Status: ENROLLING_BY_INVITATION
Conditions: E-cigarette Use|Vaping
Interventions: BEHAVIORAL: Peer Messaging|BEHAVIORAL: Peer Coaching via Text|BEHAVIORAL: Gamification|OTHER: E-Cigarette Cessation Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Can Epinephrine Coated Syringe for Subcutaneous Immunotherapy (SCIT) Reduce Large Local Reaction?
Status: COMPLETED
Conditions: Injection Reactions Site|Systemic Reactions
Interventions: DRUG: Epinephrine or normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Once Weekly GLP-1 in Persons With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Insulin Resistance|Pre Diabetes|Obesity
Interventions: DRUG: Semaglutide 1MG Injection [Ozempic]|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heterologous Booster Study of COVID-19 Protein Subunit Recombinant Vaccine in Children 12-17 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 subunit protein recombinant vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of JNJ-40411813 as Supplementary Treatment to an Antidepressant in Adults With Depression and Anxiety Symptoms
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: JNJ-40411813|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nasal Continuous Positive Airway Pressure (CPAP) on Oral Feeding in Human Neonates
Status: UNKNOWN
Conditions: Oral Feeding in Human Neonates During Nasal CPAP
Interventions: DEVICE: Infant Flow nasal CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: SGLT2 Inhibitors Prophylaxis Against Post-contrast Acute Kidney Injury in Diabetic Kidney Disease?
Status: UNKNOWN
Conditions: SGLT2i Kideny Protection Against Contrast in Diabetic Kidney
Interventions: DRUG: Empagliflozin 25 MG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acupuncture for Chronic Low Back Pain in Older Adults
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: PROCEDURE: Standard Acupuncture|PROCEDURE: Enhanced Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Tumour|Surgery
Interventions: DRUG: Tranexamic acid (TXA)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) Bioequivalence and Pharmacodynamics of Julphar Insulin R and Huminsulin® Normal
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Julphar Insulin R (soluble human insulin, biosimilar)|DRUG: Huminsulin® Normal (soluble human insulin, reference)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prenatal Interventions to Promote Exclusive Breastfeeding
Status: COMPLETED
Conditions: Breastfeeding|Intention|Health Behavior
Interventions: BEHAVIORAL: Breastfeeding Champion|BEHAVIORAL: Positive Messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Spread And Effectiveness Of Botulinum Neurotoxin A In Spastic Equinus In Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy and Botulinum Toxin
Interventions: DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Early Swallowing Recovery in Older Dysphagic Patients Afetr Anterior Cervical Spine Surgery
Status: NOT_YET_RECRUITING
Conditions: Hypopharyngeal Pressure Changes Between Before and After Swallowing Rehabiliation
Interventions: PROCEDURE: the early swallowing rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma
Status: COMPLETED
Conditions: MGMT-unmethylated Glioblastoma (GBM)|GBM
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|RADIATION: Radiation Therapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Registry for Transperineal Laser Ablation of Prostate (TPLA) for Lower Urinary Tract Symptoms
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia|Prostatic Diseases
Interventions: PROCEDURE: Transperineal Laser Ablation of Prostate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ibuprofen Bioavailability Trial With Oral Single Dose Administration.
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Ibuprofen 400 mg oral powder|DRUG: Ibuprofen 400 mg film-coated tablet|DRUG: Ibuprofen 400 mg soft capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Metamizole Versus Ibuprofen and a Short Educational Intervention Versus Standard Care in Acute Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain
Interventions: DRUG: Metamizole Sodium|DRUG: Ibuprofen 600 mg|BEHAVIORAL: Patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 2 Raltegravir Doses in Naive HIV-1-infected Patients Receiving Rifampin for Active Tuberculosis
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: efavirenz|DRUG: raltegravir|DRUG: raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate a Human Monoclonal Antibody (MAb) 10E8VLS Administered Alone or Concurrently With MAb VRC07-523LS Via Subcutaneous Injection in Healthy Adults
Status: TERMINATED
Conditions: Healthy Adult Immune Response
Interventions: BIOLOGICAL: VRC-HIVMAB095-00-AB (10E8VLS)|BIOLOGICAL: VRC-HIVMAB075-00-AB (VRC07-523LS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Personalized Variable Versus Fixed Dose Glucocorticoid Therapy in AECOPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Glucocorticoids|DRUG: Antibiotics|DRUG: Inhaled corticosteroid (ICS)|DRUG: Long-Acting Muscarinic Antagonists(LAMA)|DRUG: Short-acting beta2-agonist (SABA)|OTHER: Physical treatments|DRUG: long-acting beta2-agonist (LABA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment
Status: UNKNOWN
Conditions: Acute Stroke
Interventions: OTHER: Intravenous anesthetics|OTHER: local anesthesia|OTHER: Controlled ventilation|OTHER: Spontaneous breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia
Status: UNKNOWN
Conditions: Gestational Trophoblastic Disease|Gestational Trophoblastic Neoplasia|Gestational Trophoblastic Tumor|Gestational Trophoblastic Neoplasms
Interventions: DRUG: MTX 1|DRUG: MTX 2|BIOLOGICAL: Act-d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization Plus Hypofractionnated Radiotherapy vs. Surgery in Locally Advanced Hepatocellular Carcinoma: an IPTW Comparison
Status: COMPLETED
Conditions: Non-metastatic Hepatocellular Carcinoma
Interventions: OTHER: TACE + hypofractionated EBRT|PROCEDURE: Surgical resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cemented K-wire Fixation vs Plating for Finger Fractures
Status: COMPLETED
Conditions: Closed Fracture of Finger|Finger Fracture Open
Interventions: DEVICE: Cemented K-wire Fixation|DEVICE: Plating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Neurostimulation and Blood Flow Restriction for PFPS in Active Duty
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Interventions: DEVICE: NMES and exercise supplemented with high BFR|DEVICE: NMES and exercise supplemented with low BFR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of LIV-GAMMA SN Inj. in Primary Immune Thrombocytopenia (ITP)
Status: COMPLETED
Conditions: Immune Thrombocytopenia
Interventions: BIOLOGICAL: LIV-GAMMA SN Inj.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Compared With Interferon Alfa in Treating Patients With Stage III Melanoma
Status: TERMINATED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: BCG vaccine|BIOLOGICAL: autologous tumor cell vaccine|BIOLOGICAL: recombinant interferon alfa|DRUG: chemotherapy|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Spectroscopy With Surface Coils and Decoupling
Status: COMPLETED
Conditions: Adrenal Cortical Cancer|Brain Cancer|Breast Cancer|CNS Cancer|Colon Cancer|HEENT Cancer|Hodgkin's Disease|Kaposi's Sarcoma|Liver Cancer|Lung Cancer|Non-Hodgkin's Lymphoma|Ovarian Cancer|Pancreatic Cancer|Prostate Cancer|Rectal Cancer|Renal Cancer|Sarcoma|Squamous Cell Carcinoma|Thyroid Cancer
Interventions: DEVICE: Proton-decoupled 31P MRS at 1.5T|DEVICE: 1H Spectroscopy at 1.5T and 3T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Thromboprophylaxis With Rivaroxaban In Patients With Malignancy and Central Venous Lines
Status: COMPLETED
Conditions: Upper Extremity Deep Vein Thrombosis|Central Venous Catheter Thrombosis|Cancer
Interventions: DRUG: Rivaroxaban 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of SGLT-2 Inhibitor in Patient With Atrial Fibrillation and Diabetes Mellitus
Status: ENROLLING_BY_INVITATION
Conditions: SGLT-2 Inhibitor|Atrial Fibrillation|Diabetes Mellitus, Type 2
Interventions: DRUG: SGLT2 inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Surgical Procedures for Treatment of Persistent Nasolacrimal Duct Obstruction in Children < 4 Years Old
Status: COMPLETED
Conditions: Nasolacrimal Duct Obstruction
Interventions: PROCEDURE: Nasolacrimal balloon catheter dilation|PROCEDURE: Nasolacrimal intubation|PROCEDURE: Nasolacrimal duct probing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Lean Beef Consumption on Cardiometabolic Health and Gut Microbiome
Status: RECRUITING
Conditions: Diet Intervention
Interventions: OTHER: Lean (93%) Grass-Fed Beef|OTHER: Lean (93%) Grain-Fed Beef|OTHER: Plant-Based Meat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Ultrasound Evaluation of Fasting Residual Gastric Volume in Patients With Previous Sleeve Gastrectomy : Comparative Study With Patients Without History of Bariatric Surgeries
Status: ENROLLING_BY_INVITATION
Conditions: Fasting
Interventions: DEVICE: Ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Restorelle® Mesh Versus Native Tissue Repair for Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: Restorelle Direct Fix A|DEVICE: Restorelle Direct Fix P|PROCEDURE: Native Tissue Repair Anterior|PROCEDURE: Native Tissue Repair Posterior
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gemcitabine, Capecitabine, and Bevacizumab in Treating Patients With Metastatic or Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: capecitabine|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community I-STAR Mozambique: Community Implementation of SBIRT Using Technology for Alcohol Use Reduction in Mozambique
Status: RECRUITING
Conditions: mSBIRT - Mobile Screening, Brief Intervention, Referral to Treatment|SBIRT-CTS - Screening, Brief Intervention, Referral to Treatment Conventional Training and Supervision Strategy
Interventions: BEHAVIORAL: Screening, Brief Intervention, Referral to Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Intravenous INO-1001 Plus Oral Temozolomide to Evaluate Tolerability, Safety, and Pharmacokinetics in Patients With Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: INO-1001|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Exercise and Electrical Brain Stimulation to Improve Memory in Dementia
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease
Interventions: OTHER: tDCS|OTHER: Exercise|OTHER: Exercise Education|OTHER: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function
Status: COMPLETED
Conditions: Hepatic Function Abnormal
Interventions: DRUG: tolebrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin, Paclitaxel, and Temozolomide for Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Paclitaxel, carboplatin, temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Blood Flow Changes and Microemboli During Carotid Surgery
Status: UNKNOWN
Conditions: Carotid Endarterectomy|Percutaneous Transluminal Angioplasty|Cognitive Aspects|Diffusion Weighted MRI
Interventions: PROCEDURE: carotid stenting|PROCEDURE: carotid endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial
Status: COMPLETED
Conditions: Critical Illness
Interventions: DRUG: Ketamine / Propofol Admixture|DRUG: Etomidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study With a New Insulin Glargine Formulation and Lantus® in Japanese Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin glargine HOE901|DRUG: Insulin glargine - New formulation HOE901
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Eradication With Probiotics Combined With Triple Therapy Versus Bismuth-containing Quadruple Therapy
Status: COMPLETED
Conditions: Gastritis|Peptic Ulcer|Dyspepsia
Interventions: DRUG: Clostridium butyricum capsule|DRUG: esomeprazole|DRUG: amoxicillin|DRUG: clarithromycin|DRUG: Bacillus clotting|DRUG: Bismuth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fitting Evaluation of Hydrogel and Silicone Hydrogel Spherical Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Methafilcon A IV|DEVICE: Ocufilcon B|DEVICE: Omafilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bendamustine and IXAZOMIB (MLN9708) Plus Dexamethasone in Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: MLN9708|DRUG: Dexamethasone|DRUG: Bendamustine (multiple dose levels)|DRUG: Bendamustine (MTD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CT 327 in the "Atopy Patch Test" Model
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: DRUG: CT327 application|DRUG: Placebo|DRUG: Active comparator|DRUG: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nerve Stimulator Versus Ultrasound-guided Infraclavicular Block
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: NS-guided infraclavicular block|PROCEDURE: US-guided infraclavicular block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-pharmacological Management of Chronic Migraine
Status: UNKNOWN
Conditions: Headache
Interventions: BEHAVIORAL: Manipulative articulatory (ART) and myofascial techniques|DEVICE: Transcutaneous Electrical Nerve Stimulation|DRUG: OnabotulinumtoxinA (Prophylaxis therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Pragmatic Use of Mobile Phone Based Follow up of Actinic Keratoses Treated With Topical 5-fluorouracil
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: OTHER: teledermatology feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic Clubfoot
Status: UNKNOWN
Conditions: Congenital Clubfoot
Interventions: PROCEDURE: Minimally Invasive Carroll's Technique|PROCEDURE: Ponseti method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo-controlled Four Way Crossover Study to Asses the Effect of a Single Oral Dose of NKTR-118 on QTc Interval in Healthy Male Subjects
Status: COMPLETED
Conditions: Amount of NKTR-118 in Blood|Variation in the Heart's Electrical Cycle
Interventions: DRUG: NKTR-118|DRUG: moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of a Peer Visitation Program to Improve Patient Activation and Quality of Life During Amputation Rehabilitation
Status: UNKNOWN
Conditions: Amputation
Interventions: BEHAVIORAL: Peer Visitation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Combining Pain Neuroscience Education and Transcranial Direct Current Stimulation on Pain Catastrophizing, Kinesiophobia, and Pain in Patients With Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low-back Pain|Catastrophizing Pain|Kinesiophobia
Interventions: DEVICE: Transcranial Direct Current Stimulation|BEHAVIORAL: Pain Neuroscience Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Natural Extracts Supplementation on NASH Patients
Status: UNKNOWN
Conditions: NAFLD
Interventions: DIETARY_SUPPLEMENT: Choline - Vitamin C, E and Ampelopsis Grossedentata natural extracts|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extent of Surgical Trauma in Open and Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Chronic Calculous Cholecystitis
Interventions: PROCEDURE: Laparoscopic cholecystectomy|PROCEDURE: Open Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Optical Imaging for Pretreatment Evaluation for Cutaneous Microparticle Delivery
Status: COMPLETED
Conditions: Acne Vulgaris|Microparticles
Interventions: DRUG: Adapalene-Benzoyl Peroxide Gel 0.1-2.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Remimazolam on Opioid Induced Hyperalgesia
Status: COMPLETED
Conditions: Hyperalgesia, Mechanical
Interventions: DRUG: Remimazolam|DRUG: Desflurane|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nintedanib in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors
Status: COMPLETED
Conditions: Carcinoid Tumor|Metastatic Carcinoid Tumor|Neuroendocrine Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Nintedanib|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Examine the Drug-drug Interactions Between ACT-541468 and Citalopram in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACT541468|DRUG: ACT541468 placebo|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Ocular Changes With Alpha-2 Receptor Agonist.
Status: RECRUITING
Conditions: Glaucoma, Suspect|Aberration, Corneal Wavefront
Interventions: DRUG: Low dosage selective alpha-2 receptor agonists topical eyedrop|DRUG: High dosage selective alpha-2 receptor agonists topical eyedrop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Mechanical Ventilation on the Occurrence of Myocardial Ischemia: a Pilot Study
Status: COMPLETED
Conditions: Myocardial Ischemia|Hypoxia
Interventions: PROCEDURE: Continued ventilation|PROCEDURE: Discontinued ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of CNTO 2476 in Participants With Visual Acuity Impairment Associated With Geographic Atrophy (GA) Secondary to Age Related Macular Degeneration (AMD)
Status: WITHDRAWN
Conditions: Visual Acuity|Geographic Atrophy|Macular Degeneration
Interventions: COMBINATION_PRODUCT: CNTO 2476 (6.0 * 10^4 cells)|COMBINATION_PRODUCT: CNTO 2476 (3.0 * 10^5 cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of an Angiographic Quantitative Flow Ratio-guided Endovascular Procedure in Patients With Lower Limbs Peripheral Arterial Disease.
Status: RECRUITING
Conditions: Lower Limbs Peripheral Arterial Disease
Interventions: PROCEDURE: Preoperative ultrasound examination.|PROCEDURE: Peroperatoire angiography procedure and QFR analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transplantation of Bone Marrow Mesenchymal Stem Cell in Crohn's Disease
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: mesenchymal cell transplantation|BIOLOGICAL: mesenchymal cell and fibroblast injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of Pre-surgical Aerobic Exercise on Patients With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Preoperative Aerobic Training|Solid Tumors
Interventions: BEHAVIORAL: treadmill walking (Proof-of-Concept)|BEHAVIORAL: treadmill walking Dose-Finding / Escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Rehabilitation for Reduction of Hospitalization After Coronary Bypass and Valvular Surgery.
Status: COMPLETED
Conditions: Patients Waiting for Elective Isolated Coronary Artery Bypass Grafting (CABG)|Patients Waiting for Aortic Valve Repair/Replacement for Moderate Aortic Stenosis or Severe Regurgitation|Patients Waiting for Mitral Valve Repair/Replacement for Moderate Stenosis or Severe Regurgitation|Patients Waiting for Combined Procedures. (CAGB and Valve)
Interventions: BEHAVIORAL: Prehab Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: First-in-human Study of SAR443579 Infusion in Male and Female Children and Adult Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), High Risk-myelodysplasia (HR-MDS), or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Status: RECRUITING
Conditions: Acute Lymphocytic Leukaemia|Acute Myeloid Leukaemia Refractory|Myelodysplastic Syndromes|Blastic Plasmacytoid Dendritic Cell Neoplasia
Interventions: DRUG: SAR443579
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-based vs Intradialysis Exercise Guided by Nursing Staff
Status: COMPLETED
Conditions: End Stage Renal Disease on Dialysis
Interventions: OTHER: Intradialysis exercise training|OTHER: Home-based exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Lenvatinib and Pembrolizumab for IVC Tumor Thrombus
Status: RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Neoadjuvant Lenvatinib|DRUG: Neoadjuvant Pembrolizumab|PROCEDURE: Radical nephrectomy, IVC thrombectomy, retroperitoneal lymph node dissection|DRUG: Adjuvant Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Interstitial Thermal Therapy (LITT) for the Treatment of Pediatric Central Nervous System Tumors
Status: COMPLETED
Conditions: Brain Tumor
Interventions: DEVICE: Laser Interstitial Thermotherapy (LITT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ociperlimab With Tislelizumab and Chemotherapy in Participants With Untreated Metastatic Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced, Unresectable, or Metastatic Nonsmall Cell Lung Cancer (NSCLC)|Nonsmall Cell Lung Cancer, Stage IV
Interventions: DRUG: Ociperlimab|DRUG: Tislelizumab|DRUG: histology-based chemotherapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BIOLOGICAL: Albiglutide 30 mg|BIOLOGICAL: Albiglutide 50 mg|BIOLOGICAL: Albiglutide matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SHTC - EUROPE-1 Synergo Hyperthermia-Chemotherapy by European Urologists' Research Operation Preserving Evolution Study I
Status: WITHDRAWN
Conditions: Urinary Bladder Neoplasms|Urologic Neoplasms|Urogenital Neoplasms|Neoplasms|Neoplasms by Site|Urinary Bladder Diseases|Urologic Diseases
Interventions: DEVICE: Synergo + MMC|DRUG: Bacillus Calmette-Guérin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amifostine Plus Topotecan in Treating Patients With Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: amifostine trihydrate|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Decreasing Chemotherapy Induced Distress Using Immersive Virtual Reality in Patients With Cancer
Status: NOT_YET_RECRUITING
Conditions: Malignant Neoplasm|Cancer
Interventions: DEVICE: Virtual Reality|OTHER: Preferred activity|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Retinal Diseases|Eye Diseases|Eye Disease, Hereditary|Retinal Degeneration
Interventions: DRUG: Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Safety, Efficacy, and Pharmacokinetics of "Regorafenib" Combined With Pemetrexed and Cisplatin in Patients With Nonsquamous Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Small Cell Lung Carcinoma
Interventions: DRUG: Regorafenib (BAY73-4506) - sequential / Cisplatin / Pemetrexed|DRUG: Regorafenib (BAY73-4506) - continuous / Cisplatin / Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Mental Health for Infants Exposed to Early Adversity: A Comparison of Breaking the Cycle and Maxxine Wright
Status: RECRUITING
Conditions: Mother-Child Relations|Substance Use
Interventions: BEHAVIORAL: Breaking the Cycle Program|BEHAVIORAL: Maxxine Wright Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravascular Ultrasound Guided Drug Eluting Stents Implantation in "All-comers" Coronary Lesions （ULTIMATE Trial）
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Angiography|PROCEDURE: IVUS|PROCEDURE: DES implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Rebastinib (DCC-2036) in Combination With Carboplatin in Patients With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Solid Tumor
Interventions: DRUG: rebastinib|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GS-0272 in Participants With Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: GS-0272|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity
Status: UNKNOWN
Conditions: Hypertension|Heart Failure|Chronic Kidney Disease|Diabetes|Heart Rhythm Disorders
Interventions: DEVICE: Renal denervation with Symplicity Flex Medtronic/Ardian|DEVICE: Renal denervation with EnligHTN St. Jude Medical|DEVICE: Renal denervation with Paradise Recor|DEVICE: Renal denervation with V2 Vessix
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Darwish Test (Office Hysteroscopic Bubble Suction and Tubal Peristalsis) in Cases of Intrauterine Polyp(s)
Status: UNKNOWN
Conditions: Intrauterine Polyp
Interventions: DIAGNOSTIC_TEST: Darwish test for a free endometrial cavity|DIAGNOSTIC_TEST: Darwish test for an endometrial cavity with endometrial polyps
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Dose BAYA1040_Nifedipine: a Long Term Combination Study
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Nifedipine (Adalat, BAYA1040)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SIM-PLICITY Study: The SIMulation Project - LIstening & Intervention in Pediatric obeSITY
Status: COMPLETED
Conditions: Childhood Obesity
Interventions: BEHAVIORAL: Educational Intervention|BEHAVIORAL: Wait List Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Modafinil in Treating Fatigue in Patients With Cancer
Status: UNKNOWN
Conditions: Cognitive/Functional Effects|Depression|Fatigue|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: modafinil|PROCEDURE: cognitive assessment|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Soft Tissue Mobilization on Postsurgical Adhesions, Pain, Lumbopelvic Muscle Functions, Spinal Mobility, and Posture in Postpartum Women With Caesarean Section
Status: RECRUITING
Conditions: Postsurgical Adhesion
Interventions: OTHER: Myofascial abdominal diaphragm release|OTHER: Direct focused scar release technique|OTHER: Direct manipulations to visceral structures|OTHER: pelvic anatomy education|OTHER: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease
Status: RECRUITING
Conditions: Polycystic Kidney, Autosomal Dominant
Interventions: DRUG: Empagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab Treatment of Diabetic Macular Oedema With Bimonthly Monitoring After a Phase of Initial Treatment
Status: COMPLETED
Conditions: Diabetic Retinopathy|Macular Oedema
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantifying the Influence of Expert Modeling
Status: COMPLETED
Conditions: Competence|Self-efficacy
Interventions: OTHER: Common readings and educational handouts|OTHER: Expert Modeling|OTHER: Voice Over Power Point
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: BIBW 2992 Administered as Tablet (Final Formulation) Compared to BIBW 2992 Drinking Solution and BIBW 2992 Tablet (Trial Formulation II) in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBW 2992 MA2|DRUG: BIBW 2992 MA2|DRUG: BIBW 2992 MA2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Long-term Effect of Perinatal Tissue Mesenchyme Stem Cells in the Treatment for Caesarean Section Scars
Status: WITHDRAWN
Conditions: Cicatrix
Interventions: BIOLOGICAL: Mesenchyme Stem Cells low-dose group|BIOLOGICAL: Mesenchyme Stem Cells high-dose group|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cera™ Vascular Plug System Post-Market Clinical Follow-Up
Status: NOT_YET_RECRUITING
Conditions: Aneurysm|Endoleak|Pulmonary Arteriovenous Malformation|Portal Hypertension|Arteriovenous Fistula|Splenic Laceration
Interventions: DEVICE: Cera™ Vascular Plug System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Apical Patency on Success of Root Canal Treatment in Non Vital Teeth
Status: COMPLETED
Conditions: Apical Periodontitis
Interventions: PROCEDURE: Apical patency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Fabrazyme (Agalsidase Beta) Dosing Regimens in Treatment-naïve, Male Pediatric Patients Without Severe Symptoms
Status: COMPLETED
Conditions: Fabry Disease
Interventions: BIOLOGICAL: Agalsidase beta|BIOLOGICAL: Agalsidase beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intranasal Oxytocin on Emotion Regulation in Adolescents
Status: COMPLETED
Conditions: Emotion|Parent-Child Relations
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Therapeutic Approaches to Malnutrition Enteropathy
Status: COMPLETED
Conditions: Severe Acute Malnutrition
Interventions: DIETARY_SUPPLEMENT: Colostrum high protein powder (Neovite)|DRUG: N-Acetyl Glucosamine (GInNAC)|DRUG: Teduglutide|DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Indolent B-Cell Non-Hodgkin Lymphoma|Recurrent Indolent B-Cell Non-Hodgkin Lymphoma|Refractory Indolent B-Cell Non-Hodgkin Lymphoma|Recurrent Indolent Non-Hodgkin Lymphoma|Refractory Indolent Non-Hodgkin Lymphoma
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Endoscopic Procedure|RADIATION: Involved-site Radiation Therapy (3 Fractions)|RADIATION: Involved-site Radiation Therapy (12 Fractions)|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smartphone-Based Intervention for Sleep Disturbance in Individuals Recovering From Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Abuse With Alcohol-Induced Sleep Disorder|Alcohol Use Disorder (AUD)|Sleep Disorder|Sleep Disturbance
Interventions: BEHAVIORAL: CueToSleep (Full Intervention Package)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Community-Based Intervention With Popular Opinion Leaders (C-POL) in Texas
Status: COMPLETED
Conditions: Risk Behavior|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Community-Popular Opinion Leader Model|BEHAVIORAL: Diffusion of Innovations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Proof of Concept Study of the Effects of Administration of SCFA in Rheumatoid Arthritis (EASi-RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Short Chain Fatty Acids (SCFA) Dietary Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimum Effective Volume of 0.375% Bupivacaine in Interscalene Brachial Plexus Block
Status: UNKNOWN
Conditions: Shoulder Surgery
Interventions: DRUG: Bupivacaine 0,375%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optiflow® to Prevent Post-Extubation Hypoxemia afteR Abdominal Surgery (the OPERA Trial)
Status: COMPLETED
Conditions: Postoperative Hypoxemia
Interventions: DEVICE: Nasal high flow cannula (OptiflowTM, MR850 heated humidified, Fisher & Paykel Healthcare, Auckland, New Zealand)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION