pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Deep TMS of the Left Auditory Cortex Using the HMCIPCC Coil, in the Treatment of Patients With Tinnitus.
Status: WITHDRAWN
Conditions: Tinnitus
Interventions: DEVICE: Deep Transcranial Magnetic Stimulation|DEVICE: Deep Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Oxaliplatin and Capecitabine in Patients With Advanced Cholangiocarcinoma
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ipilimumab With or Without Vaccine Therapy in Treating Patients With Previously Treated Stage IV Melanoma
Status: WITHDRAWN
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: gp100:209-217(210M) peptide vaccine|BIOLOGICAL: gp100:280-288(288V) peptide vaccine|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy and Safety of Selective Metabolically Adaptive Radiation Dose Escalation in Locally Advanced Non-Small Cell Lung Cancer Receiving Definitive Chemoradiotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: RADIATION: Chemoradiotherapy|RADIATION: Chemoradiotherapy with Integrated Boost Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Ablative Strategies After Endovascular Radioembolization
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DEVICE: PET/MRI|RADIATION: Percutaneous ablation|RADIATION: Stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normal Saline Use With Suctioning
Status: COMPLETED
Conditions: Tracheostomy
Interventions: OTHER: 3mL of normal saline from the pink sodium chloride bullet|OTHER: Sham Comparator of 3mL normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Early Treatment With Dexamethasone in Mild Acute Pancreatitis
Status: WITHDRAWN
Conditions: Patients With Acute Pancreatitis
Interventions: DRUG: Dexamethasone acetate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Closure of Tracheoesophageal Fistulas With Occluder Device
Status: TERMINATED
Conditions: Acquired Tracheo-esophageal Fistula
Interventions: DEVICE: Fistula closure with Gore Helex Septal Occluder|DEVICE: Gore Helex Septal Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can 3D Ultrasound be Used as an Alternative to MRI to Assess Myometrial Invasion in Endometrial Cancer?
Status: UNKNOWN
Conditions: Endometrial Cancer|Endometrial Neoplasms|Endometrial Hyperplasia
Interventions: DIAGNOSTIC_TEST: 3D Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study
Status: COMPLETED
Conditions: Newborn Complication|Hyponatremia of Newborn|Hypernatremia of Newborn|Fluid Therapy|Sodium Chloride|Isotonic Dehydration
Interventions: DRUG: Intravenous isotonic fluid - NaCl 131-154 mmol/L in 5% dextrose|DRUG: Intravenous Hypotonic fluid- Sodium Chloride < 130 mmol/L
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery
Status: TERMINATED
Conditions: Colorectal Cancer|Pain|Other Complications
Interventions: DRUG: Ropivacaine + opioid epidurally|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Patient Satisfaction Of Metered Dose Inhaler (MDI) With Counter In Asthmatics And Chronic Obstructive Pulmonary Disease Patients (COPD).
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone/Salmeterol HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracheal Palpation of Sliding Cuff to Assess Endotracheal Tube Location
Status: COMPLETED
Conditions: Anesthesia Intubation Complication
Interventions: PROCEDURE: cuff palpation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual-spatial and Visual-perceptual Disorders Following Cerebellar Strokes
Status: UNKNOWN
Conditions: Stroke, Ischemic|Cerebellar Lesions
Interventions: DEVICE: Additional MRI sequences|OTHER: Neuropsychological assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Developing Treatment, Treatment Validation and Treatment Scope in the Setting of an Autism Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Docosahexanoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise and Omega-3 on Metabolic Health in Elderly
Status: COMPLETED
Conditions: Metabolism Disorder|Adiposity|Inflammatory Response
Interventions: BEHAVIORAL: Exercise training|DIETARY_SUPPLEMENT: omega 3 supplementation|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcutaneous Mechanical Nerve Stimulation (TMNS) by Vibration in the Preservation and Restoration of Urinary Continence and Erectile Function and in the Treatment of Erectile Dysfunction and Urinary Incontinence in Conjunction With Nerve Sparing Radical Prostatectomy
Status: COMPLETED
Conditions: Erectile Dysfunction|Urinary Incontinence
Interventions: DEVICE: Transcutaneous mechanical nerve stimulation (TMNS)|OTHER: Pelvic floor muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study to Evaluate Bone Loss, Survival Rate and Stability of ICE Implant
Status: COMPLETED
Conditions: Implant Clinical Survival|Dental Implant Bone Loss
Interventions: DEVICE: ICE dental implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sup-Icu RENal (SIREN)
Status: COMPLETED
Conditions: Critical Illness|Acute Kidney Injury|End-stage Renal Disease|Renal Replacement Therapy|Proton Pump Inhibitor
Interventions: DRUG: Pantoprazole|DRUG: Saline 0.9% (matching placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Microdose Trial Investigating Binding of [68Ga]Ga-DOTA-CYS-ATH001 in Healthy Subjects and Different Patient Groups.
Status: RECRUITING
Conditions: MASH|PSC|Fibrostenotic Crohn's Disease|Healthy Volunteers
Interventions: DRUG: [68Ga]Ga-DOTA-Cys-ATH001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Music Therapy to Prevent Hospital-acquired Delirium in Parkinson's Disease and Dementia With Lewy Bodies
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease|Dementia, Lewy Body|Delirium
Interventions: BEHAVIORAL: Music therapy intervention|OTHER: Non-guided music listening|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF
Status: RECRUITING
Conditions: Microvascular Coronary Artery Disease|Heart Failure With Reduced Ejection Fraction
Interventions: DIAGNOSTIC_TEST: stress perfusion cardiac magnetic resonance|DIAGNOSTIC_TEST: cardiopulmonary exercise test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Dotarem® (Gd-DOTA) Versus Gadovist® (Gd-DO3A-butrol) for Late Gadolinium Enhancement Cardiac Magnetic Resonance
Status: UNKNOWN
Conditions: Coronary Artery Disease|Cardiomyopathy
Interventions: DRUG: Cardiac MRI taken using contrast agent, Dotarem® (Gd-DOTA)|DRUG: Cardiac MRI with contrast agent, Gadovist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Terminal Visual Feedback Therapy After Immersive Virtual Reality in Patients With Chronic Shoulder Pain
Status: NOT_YET_RECRUITING
Conditions: Shoulder Pain|Movement Disorders
Interventions: DEVICE: Oculus Quest II|DEVICE: Oculus Quest II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LASIK Flap Thickness and Visual Outcomes Using the WaveLight FS200 Femtosecond Laser
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: FS200 femtosecond laser LASIK|DEVICE: IntraLase femtosecond laser LASIK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Bowel Disease (IBD)
Interventions: DRUG: Oxygen Gas for Inhalation|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study
Status: RECRUITING
Conditions: Alzheimer's Disease (AD)
Interventions: DEVICE: Dreem headband|DEVICE: Dreem headband
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Influence of Persistent Food Allergy on Nutritional Status of Children With Food Allergy
Status: COMPLETED
Conditions: Food Allergy
Interventions: BIOLOGICAL: Blood sample analysis|OTHER: Anthropometrics measurement - at inclusion to the study (all groups).|RADIATION: Bone mineral density measurement (DXA)|OTHER: Influence of food allergy on growth (intervention groups)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Parenteral Fish Oil in Major Laparoscopic Abdominal Surgery
Status: UNKNOWN
Conditions: Gastric Tumor|Pancreatic Tumor|Liver Tumor
Interventions: DRUG: MCT/LCT and fish oil|DRUG: MCT/LCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Accuracy of a Subset of the Length-109 Probe Set Panel (a Genetic Test) in Predicting Response to Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: BIOLOGICAL: Golimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I, Dose Study to Look at the Safety and Pharmacokinetics of AZD8835 in Patients With Advanced Solid Tumours
Status: COMPLETED
Conditions: Advanced Solid Malignancies|Breast Cancer - ER+, HER2 -|Breast Cancer - ER+, HER2-, PIK3CA Gene Mutation
Interventions: DRUG: AZD8835|DRUG: AZD8835|DRUG: AZD8835 in combination with fulvestrant|DRUG: AZD8835 in combination with fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Techniques for Emergency Cricothyroidotomy
Status: COMPLETED
Conditions: Intubation, Intratracheal
Interventions: OTHER: Seldinger technique|DEVICE: Surgical Airway Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of DMPA With HIV PrEP
Status: COMPLETED
Conditions: HIV/AIDS|Contraception
Interventions: COMBINATION_PRODUCT: tenofovir/emtricitabine|DRUG: DMPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DEVICE: Therasphere 90Y|DEVICE: Microwave Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Adults With Grass Pollen-induced Rhinoconjunctivitis
Status: COMPLETED
Conditions: Allergy
Interventions: DRUG: 5-grass mix SLIT-drops|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 6-Months Infliximab Or Placebo Study In UA At High Risk Of RA:Clinical,Radiological And Synovial Benefit
Status: COMPLETED
Conditions: Undifferentiated Arthritis
Interventions: DRUG: Infliximab|DRUG: sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Paclitaxel in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus or Stomach
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: irinotecan hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of OMS103HP-S Administered in Joint Irrigation Solution to Subjects Undergoing Arthroscopic Meniscectomy
Status: COMPLETED
Conditions: Meniscal Tear
Interventions: DRUG: OMS103HP-S|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Bosentan in Patients With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: bosentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Immunogenicity and Safety of Ad26.COV2.S's COVID-19 Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Vaccine Reaction|SARS CoV 2 Infection|Vaccine Adverse Reaction
Interventions: BIOLOGICAL: Ad26.COV2.S
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
Status: RECRUITING
Conditions: PPA|Non-fluent Aphasia|Apraxia of Speech|Primary Progressive Non-fluent Aphasia|Primary Progressive Aphasia
Interventions: DRUG: AV-1451
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Phenethyl Isothiocyanate in Lymphoproliferative Disorders
Status: WITHDRAWN
Conditions: Leukemia|Lymphoproliferative Disorders
Interventions: DRUG: Phenethyl Isothiocyanate (PEITC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Change and the Risk of Chronic Pain Following Hip and Knee Arthroplasties
Status: NOT_YET_RECRUITING
Conditions: Persistent Postsurgical Pain|Arthritis Knee|Arthropathy of Knee|Arthropathy of Hip|Weight Loss|Weight Gain|Obesity
Interventions: OTHER: Weight gain|OTHER: Weight loss|OTHER: Weight unchanged
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery
Status: UNKNOWN
Conditions: Analgesia|Breast Cancer
Interventions: PROCEDURE: Ultrasound (US) bi-level erector spinae block|DRUG: levobupivacaine|DRUG: Ketamine|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Integration of Neutron Therapy in the Treatment Plan for Stage III Non-Small Cell Lung Cancer (NSCLC)
Status: WITHDRAWN
Conditions: Lung Cancer
Interventions: RADIATION: Radiation Therapy|DRUG: Chemotherapy - Squamous Cell Histologies|DRUG: Chemotherapy - NSCLC other than squamous cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability, Sensitivity and Validity of the 6 Minute Step Test in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Six-minute Step Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reduction of Postherpetic Neuralgia in Herpes Zoster
Status: COMPLETED
Conditions: Herpes Zoster|Post-herpetic Neuralgia
Interventions: DRUG: Gabapentin|DRUG: Valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Everolimus|DRUG: Pembrolizumab|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Effectiveness and Safety of Efgartigimod in Chinese Patients With Primary Membranous Nephropathy (ZL-1103-014)
Status: RECRUITING
Conditions: Membranous Nephropathy
Interventions: BIOLOGICAL: efgartigimod IV|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel/STI-3031 Complex (AP160-Complex) for the Treatment of Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Unresectable Melanoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Nab-paclitaxel/Danburstotug Complex AP160
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Twelve-month, Multicenter, Open-label, Randomized Study of the Safety, Tolerability and Efficacy of Everolimus With Basiliximab, Corticosteroids and Two Different Exposure Levels of Tacrolimus in de Novo Renal Transplant Recipients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Everolimus (RAD001)|DRUG: Tacrolimus|DRUG: Basiliximab|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Efficacy of MK-1293 Compared to Lantus™ in Participants With Type 1 Diabetes Mellitus (T1DM) (MK-1293-003)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: MK-1293|DRUG: Lantus™|DRUG: Prandial Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clopidogrel as Adjunctive Reperfusion Therapy - Thrombolysis in Myocardial Infarction
Status: COMPLETED
Conditions: Acute Coronary Syndromes
Interventions: DRUG: Clopidogrel (SR25990)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Cancer of the Colon or Rectum That Has Spread
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Colorectal Tumors|Colorectal Carcinoma|Colorectal Neoplasm
Interventions: BIOLOGICAL: Nivolumab|DRUG: Trametinib|BIOLOGICAL: Ipilimumab|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postendodontic Pain on Using Max-i-Probe vs NaviTip as Irrigation Needles
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DEVICE: Max-i-Probe|DEVICE: NaviTip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Exploring the Impact of " ACP Board Game for Life" on Death Preparation and Anxiety in Patients With Stage 4 and 5 Chronic Kidney Diseases: A Pilot Study
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Renal Failure|Chronic Renal Insufficiency|End of Life Care|Advance Care Planning|Death Anxiety
Interventions: OTHER: ACP board game for life
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Postoperative|Opioid Use
Interventions: DRUG: Gabapentin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: YY-20394 、GEMOX Treatment Diffuse Large B-cell Lymphoma Single Arm, Open, Multicentrized Phase 1b/2 Clinical Trial
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: YY-20394
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of DWP14012 in Chinese Patients With Reflux Esophagitis
Status: COMPLETED
Conditions: Reflux Esophagitis
Interventions: DRUG: DWP14012
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Amino Acid Based Moisturizing Cream as Part of the Daily Standard Skincare Regimen Recommended During Radiation Therapy
Status: NOT_YET_RECRUITING
Conditions: Erythema|Radiation Therapy, Secondary Skin Reactions
Interventions: OTHER: VS-200Cr|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Smoking Interventions in General Medical Practices
Status: UNKNOWN
Conditions: Tobacco Smoking|Nicotine Dependence
Interventions: BEHAVIORAL: Counselling Intervention|BEHAVIORAL: Expert-system intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)|Acute Lymphoblastic Leukemia (ALL)|Myelodysplastic Syndrome (MDS)|Mixed Phenotype Acute Leukemia (MPAL)
Interventions: DRUG: Selinexor|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: methotrexate/hydrocortisone/cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma, Ocular Hypertension
Interventions: DRUG: STN1012600 ophthalmic solution 0.002%|DRUG: Latanoprost ophthalmic solution 0.005%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contribution of 18F-FDG PET-CT in the Diagnosis and the Detection of Peripheral Emboli of Infectious Endocarditis on Native Valves
Status: COMPLETED
Conditions: Endocarditis
Interventions: DIAGNOSTIC_TEST: Whole-body 18F-FDG PET-CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ABR Characteristics and Salivary Cortisone Concentration in Noise-exposed Workers
Status: UNKNOWN
Conditions: Sensorineural Hearing Loss|Noise Induced Hearing Loss|Auditory Nerve; Lesion
Interventions: DIAGNOSTIC_TEST: ABR and salivary cortisone testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: S0601 Rituximab, Combination Chemotherapy, and Bortezomib Followed by Bortezomib Alone in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Preoperative Education, and Follow-up Sessions of Patients With Total Hip and Knee Arthroplasty (ESIPPES)
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Hip|Arthroplasty, Replacement, Knee
Interventions: OTHER: Control group|OTHER: Intervention group A|OTHER: Intervention group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care
Status: RECRUITING
Conditions: Childhood Cancer|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Survivorship mobile application|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: DAS181 Single Dose Escalation Study in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DAS181|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KDIGO Bundle to Prevent AKI in Sepsis
Status: UNKNOWN
Conditions: Septic Acute Kidney Injury
Interventions: PROCEDURE: Preventive recommendations for kidney disease: guidelines for improving overall outcomes (KDIGO) for AKI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Challenges in Achieving Adequate Vitamin D Status in the Adult Population/ Part 2
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Oil-based vitamin D|DIETARY_SUPPLEMENT: Water-based vitamin D|DIETARY_SUPPLEMENT: Vitamin D capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decompression of Odontogenic Cysts Using an Appliance Fabricated With a Fully Digital Workflow
Status: RECRUITING
Conditions: Odontogenic Cysts
Interventions: DIAGNOSTIC_TEST: Preoperative Cone Beam Computed Tomography (CBCT) scan|PROCEDURE: tooth removal and cystostomy|PROCEDURE: Decompression|DIAGNOSTIC_TEST: Postoperative Cone Beam Computed Tomography (CBCT) scan|PROCEDURE: Cyst Enucleation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: OTHER: Ventilation strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: S9704-S0014-S0313A Studying Genes in Samples From Patients With Limited or Advanced Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: GENETIC: RNA analysis|GENETIC: gene expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metronomic Capecitabine Plus Aromatase Inhibitor for First Line Treatment in HR(+), Her2(-) Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: Aromatase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Electroacupuncture (EA) on the Success of Inferior Alveolar Nerve Block (IANB) and Post-operative Pain Relief in Mandibular Molar With Symptomatic Irreversible Pulpitis (SIP) Among Malaysians: A Study Protocol for Randomized Double-Blinded Clinical Pilot Study
Status: RECRUITING
Conditions: Symptomatic Irreversible Pulpitis (SIP)
Interventions: OTHER: Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Colon Cleansing Quality Between the Setting of Colon Cleansing Room and the Standard Colon Preparation in a Community Base Setting -- a Prospective Randomized Controlled Trial
Status: COMPLETED
Conditions: Colon Cleansing Level
Interventions: PROCEDURE: colonoscopic examination in colon cleansing room
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-Tumor Activity of the Oral Anaplastic Lymphoma Kinase (ALK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Brigatinib (AP26113)
Status: COMPLETED
Conditions: Lymphoma, Large-Cell, Anaplastic|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Brigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated, Multidisciplinary, Person-centered Care for Patients With Complex Comorbidities: Heart, Kidney and Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Chronic Kidney Diseases|Cardiovascular Diseases|Chronic Disease|Multimorbidity
Interventions: OTHER: CareHND
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of a New Implant Neck Configuration on Hard and Soft Tissue Healing
Status: UNKNOWN
Conditions: Implant Geometry, Osseointegration, Soft Tissue Volume, Marginal Bone Levels, Soft Tissue Recession, Volumetric Analysis
Interventions: PROCEDURE: dental implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men
Status: NOT_YET_RECRUITING
Conditions: Hypogonadism, Male|Testosterone Deficiency|Prostate Cancer|Androgen Deficiency|Metabolic Disease|Metabolic Syndrome|Metabolic Disturbance|Obesity|Cardiovascular Diseases|NAFLD|Diabetes
Interventions: DRUG: Testosterone|DRUG: GnRH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Better Outcomes for Anticoagulation Treatment Through Observation of Atrial Rhythm
Status: COMPLETED
Conditions: Non-valvular Atrial Fibrillation
Interventions: DEVICE: Alive Cor Kardia mobile electrocardiogram monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SleepWell24: An Innovative Smartphone Application to Improve PAP Adherence
Status: COMPLETED
Conditions: Obstructive Sleep Apnea of Adult
Interventions: BEHAVIORAL: SleepWell24 Application|OTHER: Usual Care Plus Activity Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics, Safety and Tolerability of GSK557296 in Healthy Women Volunteers After Single and Repeat Dosing
Status: COMPLETED
Conditions: Embryo Transfer
Interventions: DRUG: GSK557296 10 mg|DRUG: GSK557296 150 mg|DRUG: GSK557296 dose 3|DRUG: GSK557296 dose 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
Status: RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: DRUG: Nicotine Replacement|OTHER: Questionnaire Administration|DEVICE: Vaping|DEVICE: Vaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: NKTR-214|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Upper Versus Lower Limb Responses to Higher Versus Lower Load Resistance Training in Young Men
Status: COMPLETED
Conditions: Muscle Hypertrophy|Muscle Strength
Interventions: BEHAVIORAL: Unilateral resistance exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Octreotide With or Without Prednisone in Treating Patients With Metastatic or Recurrent Thymoma
Status: COMPLETED
Conditions: Thymoma and Thymic Carcinoma
Interventions: DRUG: octreotide acetate|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for Health Products in Emotional Disorders and Insomnia
Status: NOT_YET_RECRUITING
Conditions: Emotional; Disorder|Insomnia
Interventions: DIETARY_SUPPLEMENT: Extra Strength VitaJoy (ES/VJ)|DIETARY_SUPPLEMENT: Extra Strength Vita Calm (ES/VC)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Interventions: DRUG: Nexium 40 mg|DRUG: amoxicillin 1.5 gr|DRUG: doxycycline 200 mg|DRUG: Nexium 20 mg|DRUG: clarythromicin 500 mg|DRUG: amoxicillin 1gr
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of the Combination of Tamsulosin and Tadalafil in Men With Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia and Erectile Dysfunction
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia|Erectile Dysfunction
Interventions: DRUG: Tamsulosin 0.2mg|DRUG: Tadalafil 5mg|DRUG: Placebo for Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission
Status: COMPLETED
Conditions: HIV Infections|AIDS|Sexually Transmitted Diseases|HIV Seroconversion
Interventions: DRUG: Carraguard (PC-515)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Maternal Depression in Home Visitation: Mother and Child Impacts
Status: COMPLETED
Conditions: Depressive Disorder in Mothers
Interventions: BEHAVIORAL: In-Home Cognitive Behavioral Therapy|BEHAVIORAL: Present-Centered Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Eptinezumab Administered Intravenously in Participants Experiencing Acute Attack of Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Eptinezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Ventilation- Weaning and Thoracic Impedance Tomography
Status: UNKNOWN
Conditions: Weaning From Mechanical Ventilation
Interventions: DEVICE: Variable PSV|DEVICE: Conventional PSV|DEVICE: Automated PSV|DEVICE: NAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navelbine And Radiotherapy in Locally Advanced Lung Cancer
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Navelbine|RADIATION: 66 Gy/33F|RADIATION: 60 Gy/30F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blinded Trial of Household-based Chlorination in India
Status: COMPLETED
Conditions: Diarrhoea
Interventions: BEHAVIORAL: Household-based water treatment with NADCC tablets|BEHAVIORAL: Household-based water treatment with placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MK-0646 and Gemcitabine +/- Erlotinib for Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Pancreatic Adenocarcinoma
Interventions: DRUG: MK-0646|DRUG: Gemcitabine|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of NVG-111 in Relapsed/Refractory ROR1+ Malignancies
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukaemia|Small Lymphocytic Lymphoma|Mantle Cell Lymphoma|Follicular Lymphoma|Diffuse Large B Cell Lymphoma|Non-small Cell Lung Cancer (NSCLC)|Malignant Melanoma
Interventions: DRUG: NVG-111
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALPN-202 With PD-1 Inhibition in Advanced Malignancies
Status: TERMINATED
Conditions: Advanced Solid Tumor|Lymphoma
Interventions: DRUG: ALPN-202|DRUG: pembrolizumab KEYTRUDA®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Amyloid Plaque Deposition in Chemotherapy-Induced Cognitive Impairment
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: [18F]Flutemetamol|DRUG: [18F]fluoro-2-deoxy-D-glucose (FDG)|DIAGNOSTIC_TEST: Functional Magnetic Resonance Imaging (fMRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Radio-chemotherapy With or Without Panitumumab (Vectibix®) in Irresectable Squamous Cell Carcinoma or Adenocarcinoma of the Oesophagus
Status: TERMINATED
Conditions: Irresectable Squamous Cell or Adenocarcinoma of the Oesophagus
Interventions: DRUG: CRT + Panitumumab|DRUG: Concurrent chemoradiation therapy without panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise on Brain Functions
Status: COMPLETED
Conditions: Pulmonary|EEG
Interventions: OTHER: Action observation and motor imagery|OTHER: Active breathing exercise|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of LY2928057 in Hemodialysis Participants
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Kidney Disease, Chronic
Interventions: DRUG: LY2928057|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ferrochelating Treatment in Patients Affected by Neurodegeneration With Brain Iron Accumulation (NBIA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Neurodegenerative Disease|Iron Overload
Interventions: DRUG: Deferiprone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPAP and NIV Interfaces : Side-effects in Home Care Patients
Status: COMPLETED
Conditions: Interface, Mask|Continuous Positive Airway Pressure (CPAP)|Non Invasive Ventilation (NIV)|Hyperventilation Anxiety|Sleep Apnea Syndrome (OSAS)
Interventions: OTHER: self questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open Label, Randomized, Crossover Study To Estimate The Pharmacokinetics And Evaluate The Safety Following A Single Dose Of Azithromycin 2g Extended-Release Powder For Oral Suspension With A 3-Day Dosing Regimen Of Azithromycin 500mg Tablet In Chinese Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: azithromycin (Zithromax)|DRUG: azithromycin (Zithromax)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Clinical Research of Mesylate Apatinib Combined With Docetaxel and S-1 as the First-line Treatment of Metastatic Gastric Cancer
Status: UNKNOWN
Conditions: Metastatic Gastric Cancer
Interventions: DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRI102 in the Treatment of Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: TRI102|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function
Status: COMPLETED
Conditions: Alzheimer's Disease|Obesity|Diabetes Mellitus
Interventions: OTHER: Boost (R) 5-2 diet|OTHER: Healthy Living Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral NSAI Versus Paracetamol or Placebo as a Second Line Treatment for Renal Colics
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: Piroxicam|DRUG: Placebo|DRUG: paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Neuraceq™ PET for Detection of Brain Changes in Young Athletes Post-concussion
Status: COMPLETED
Conditions: Concussion, Brain
Interventions: DIAGNOSTIC_TEST: NeuraCeq PET imaging with intravenous (IV) dose of 300MBq of Neuraceq™ ([F-18]Florbetaben)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Azilsartan medoxomil and chlorthalidone|DRUG: Azilsartan medoxomil and hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Regimen for Stage III (N2) NSCLC Using Induction Treatment Followed by Resection
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Stage IIIA
Interventions: OTHER: Neoadjuvant Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Depth of Botulinum Neurotoxin Injection for Treatment of Glabellar Lines
Status: ACTIVE_NOT_RECRUITING
Conditions: Glabellar Frown Lines
Interventions: DRUG: onabotulinumtoxinA at a depth of 2mm|DRUG: onabotulinumtoxinA at a depth of 4mm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT