pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes
Status: UNKNOWN
Conditions: Pre Diabetes|Exercise|Metformin|Atherosclerosis
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Probiotic Administration to Modulate the Airway Microbiome in Obese Asthmatic Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DIETARY_SUPPLEMENT: Seeking Health Probiota Bifido
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis
Status: COMPLETED
Conditions: Breast Cancer|Bone Metastases
Interventions: DRUG: Dasatinib|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Intravenous Iron to Treat Anaemia in Major Surgery
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: Ferric carboxymaltose|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trenev Trio/Healthy Trinity for Symptoms of Diarrhea-predominant Irritable Bowel Syndrome (IBS) and Functional Dyspepsia
Status: TERMINATED
Conditions: IBS-D and Functional Dyspepsia
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of High-level Laser and Electro-cautery in Lingual Frenotomy Surgeries in Infants
Status: UNKNOWN
Conditions: Lingual Frenum|High Power Laser|Breast Feeding
Interventions: PROCEDURE: Electro cautery surgery|PROCEDURE: High power diode laser surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating PK of Ustekinumab Administered Orally Via RaniPill™ Capsule
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Stelara|COMBINATION_PRODUCT: RT-111 (0.5mg)|COMBINATION_PRODUCT: RT-111 (0.75mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of SEEOX and SOX Regimens in Stage ⅢB/ⅢC Gastric Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Stomach Neoplasms|Gastric Cancer
Interventions: DRUG: oxaliplatin|DRUG: etoposide|DRUG: pharmorubicin|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Abuse Potential of Lasmiditan in Participants Who Are Recreational Drug Users
Status: COMPLETED
Conditions: Recreational Drug Use|Prescription Drug Abuse (Not Dependent)
Interventions: DRUG: Lasmiditan|DRUG: Alprazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Fasinumab (REGN475) in Healthy Japanese and Caucasian Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Fasinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Effectiveness and Safety of JNJ-42160443 in Patients With Diabetic Painful Neuropathy
Status: TERMINATED
Conditions: Diabetic Neuropathy
Interventions: DRUG: JNJ-42160443 (1 mg)|DRUG: JNJ-42160443 (3 mg)|DRUG: JNJ-42160443 (10 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Antagonist Wear Behavior and Patient Satisfaction of Zirconia Reinforced Lithium Silicate Glass When Compared to Monolithic Zirconia
Status: UNKNOWN
Conditions: Wear of the Natural Enamel
Interventions: OTHER: zirconia reinforced lithium silicate glass ceramic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Longidaze in the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms|Prostatic Hyperplasia
Interventions: DRUG: bovhyaluronidase azoximer|DRUG: tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Healthy Volunteers
Interventions: DRUG: fostamatinib|DRUG: rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effectiveness and Safety of SKI-O-703 in Patients Experiencing Active Rheumatoid Arthritis Despite Treatment With Conventional Therapies.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: SKI-O-703|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block for Post-operative Analgesia Following Cesarean Section
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: TAPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation
Status: NOT_YET_RECRUITING
Conditions: Emergence Agitation
Interventions: DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare The Ability of Different Anti-HIV Drugs to Decrease Viral Load After Nelfinavir (an Anti-HIV Drug)Treatment Failure
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine/Zidovudine|DRUG: Ritonavir|DRUG: Amprenavir|DRUG: Efavirenz|DRUG: Saquinavir|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Quadruple Therapy (VX-222, Telaprevir,Peginterferon-Alfa-2a, Ribavirin) in Subjects With Chronic Hepatitis C With Compensated Cirrhosis
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus
Interventions: DRUG: VX-222|DRUG: telaprevir|DRUG: ribavirin|BIOLOGICAL: peginterferon-alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Innovations in the Treatment of Sexual Health Post Prostate Cancer Treatment: Comparing Mindfulness vs. CBT
Status: COMPLETED
Conditions: Prostate Cancer|Sexual Dysfunctions, Psychological|Sexual Dysfunction, Physiological|Sexual Dysfunction Male|Relationships, Marital|Prostatic Neoplasms
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy (CBT)|BEHAVIORAL: Mindfulness-Based Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect and Safety Study of GP/FP Regimens in Advanced Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Neoplasms
Interventions: DRUG: gemcitabine and cisplatin|DRUG: 5-Fluorouracil and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Anaplastic Astrocytoma
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion.
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma|Hypertension Ocular
Interventions: DEVICE: Pulsed Electromagnetic Field Therapy|DRUG: Seawater eyedrops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine in Combination With Aromatase Inhibitor Versus Aromatase Inhibitors, in Hormonal Receptor Positive Recurrent or Metastatic Breast Cancer Patients, Randomized Controlled Study
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Capecitabine plus aromatase inhibitor|DRUG: A.I.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Evaluation of Mineral Trioxide Aggregate and Biodentine as Pulp Medicaments in Primary Molars
Status: UNKNOWN
Conditions: Pulp Disease, Dental
Interventions: PROCEDURE: Direct Pulp Capping|PROCEDURE: Partial Pulpotomy|PROCEDURE: Pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PoLyglycolic Acid Felt reiNforcEmenT of the PancreaticoJejunostomy (PLANET-PJ Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Disease of Pancreatic or Periampullary Lesions
Interventions: DRUG: PGA felt reinforcement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous Disease
Status: COMPLETED
Conditions: Chronic Granulomatous Disease
Interventions: DRUG: Interferon Gamma-1B
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG
Status: TERMINATED
Conditions: High Grade Glioma|BRAF V600E|BRAF V600K|Anaplastic Astrocytoma|Anaplastic Pleomorphic Xanthoastrocytoma|Gliosarcoma|Glioblastoma
Interventions: DRUG: Encorafenib|DRUG: Binimetinib|BIOLOGICAL: Research Bloods|BIOLOGICAL: Tumor Tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative Coronary Angiography Versus Imaging GUIDancE for Bioresorbable Vascular Scaffold Implantation
Status: TERMINATED
Conditions: Percutaneous Transluminal Coronary Angioplasty
Interventions: PROCEDURE: QCA and Aspirin|PROCEDURE: QCA and Clopidogrel|PROCEDURE: Imaging guided and Aspirin|PROCEDURE: Imaging guided and Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Autobiographical Memory Specificity Training for the Reduction of Depressive Symptomatology
Status: UNKNOWN
Conditions: Training Group|Control Group
Interventions: BEHAVIORAL: Autobiographical Memory Specificity Training PESCAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endurant Bifurcated and Aorto-Uni-Iliac (AUI) Stent Graft System
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysms
Interventions: DEVICE: Endurant Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Topical Clobetasol on Gingival Crevicular Fluid miRNAs in Subjects Affected by Oral Lichen Planus
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DRUG: Clobetasol Topical Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
Status: RECRUITING
Conditions: C3G
Interventions: DRUG: Placebo|DRUG: iptacopan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Relapsed and Refractory Gray-Zone Lymphoma (GZL), Primary Central Nervous System Lymphoma (PCNSL), and Other Extranodal Diffuse Large B-cell Lymphomas
Status: COMPLETED
Conditions: Non-Hodgkin Lymphoma|Lymphoma|Diffuse Large B-Cell Lymphoma|Gray-zone Lymphoma|Primary Central Nervous System Lymphoma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abuse Liability of Pregabalin and Its Effects on Benzodiazepine Withdrawal Symptoms
Status: TERMINATED
Conditions: Substance-Related Disorders
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Pleural Mesothelioma Malignant Advanced
Interventions: DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Bevacizumab|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroclinical Correlation of Anxiety
Status: RECRUITING
Conditions: Anxiety Disorder|Generalized Anxiety Disorder|Drug Resistant Epilepsy
Interventions: BEHAVIORAL: Anxiety-induced task|BEHAVIORAL: Neuropsychiatric assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Two Guided Transfusion Strategies on Blood Product Requirements in Liver Transplantation.
Status: UNKNOWN
Conditions: Fibrin Blood Clot
Interventions: DRUG: Fibrinogen Concentrate (Human) 1 MG [RiaSTAP]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia
Status: RECRUITING
Conditions: Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Blinatumomab|DRUG: Methotrexate|DRUG: Cytarabine|DRUG: Mercaptopurine|DRUG: Prednisone|DRUG: Pegfilgrastim|DRUG: Inotuzumab ozogamicin|DRUG: Rituximab|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR-guided Focused Ultrasound Treatment of Prostate Cancer: Focal Therapy for Locally Non-Advanced Disease
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: ExAblate 2100; InSightec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Accuracy of a CAD/CAM Surgical Template for Mandible Distraction
Status: UNKNOWN
Conditions: Facial Asymmetry|Mandible; Hypoplasia, Unilateral Condylar|Distraction of Bone
Interventions: DEVICE: CAD/CAM Surgical Template
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs. Placebo Plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer (MK-3475-355/KEYNOTE-355)
Status: COMPLETED
Conditions: Triple Negative Breast Cancer (TNBC)
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Nab-paclitaxel|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Normale Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCD
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: DRUG: Memantine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab & Cabozantinib in Patients With Head and Neck Squamous Cell Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Head and Neck Carcinoma|Paranasal Sinus Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma|Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Oral Cavity Squamous Cell Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVC Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVC Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7|Unresectable Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Cabozantinib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System
Status: WITHDRAWN
Conditions: Visceral Artery Aneurysms|Arteriovenous Malformations
Interventions: DEVICE: Penumbra Ruby Coil System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Follow-up of Lichtenstein's Operation Versus Mesh Plug Repair
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Lichtenstein's operation|PROCEDURE: Mesh Plug Repair|DRUG: Opiate|DRUG: Paracetamol|DRUG: non-steroidal anti-inflammatory drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Effectiveness Study of Telaprevir in Chronic, Genotype 1, Hepatitis C Patients That Failed Previous Standard Treatment
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Telaprevir|DRUG: Peg-IFN-alfa-2a|DRUG: Ribavirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Weekly Taxotere™ With Iressa™ /Placebo in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Gefitinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Music and Ambient Noise Cancellation in Patients Undergoing Total Knee Arthroplasty (TKA)
Status: RECRUITING
Conditions: Knee Osteoarthritis|Anxiety|Post Operative Pain|Noise Exposure
Interventions: PROCEDURE: No noise cancellation and no music playing|PROCEDURE: Noise cancelled but not allowed to listen to music|PROCEDURE: Music is played but noise is not cancelled
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Safety and Effectiveness of Didanosine Plus Stavudine Plus Nevirapine Combined With MKC-442 in HIV-Infected Patients Who Have Not Had Success With Protease Inhibitors
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Emivirine|DRUG: Hydroxyurea|DRUG: Nevirapine|DRUG: Stavudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Different HES Coload Volumes on the 90% ED of Norepinephrine
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Hydroxyethyl starch coload - 0 ml/kg|DRUG: Hydroxyethyl starch coload - 5 ml/kg|DRUG: Hydroxyethyl starch coload - 10 ml/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regadenoson Combined With Symptom-Limited Exercise in Patients Undergoing Myocardial Perfusion Imaging
Status: COMPLETED
Conditions: Coronary Artery Disease|Myocardial Ischemia
Interventions: DRUG: Regadenoson|OTHER: Symptom-limited exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Shingrix In Recipients of Allogeneic Transplants
Status: RECRUITING
Conditions: Bone Marrow Transplant|Stem Cell Transplant
Interventions: DRUG: Zoster Vaccine Recombinant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of BCAA Supplementation on Muscle Mass, Muscle Quality and Molecular Markers of Muscle Regeneration in CLD Patients
Status: COMPLETED
Conditions: Chronic Liver Disease
Interventions: DIETARY_SUPPLEMENT: Branched Chain Amino Acid|DIETARY_SUPPLEMENT: Whey Protein concentrate powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Psilocybin Analog (CYB003) in Humans With Major Depressive Disorder
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: CYB003|BEHAVIORAL: Psychological Support|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the COTID (Community Occupational Therapist in Dementia) Program and Usual Occupational Therapy Care on Recurrence of Falls at 12 Months in Elderly People With Neurocognitive Disorders Who Had Been Hospitalized for Falls, After Their Return Home
Status: NOT_YET_RECRUITING
Conditions: Nervous System Diseases
Interventions: BEHAVIORAL: COTID program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Studying Tumor Tissue Samples to Learn More About DNA Changes and Response in Patients With Breast Cancer Treated With Bevacizumab on Clinical Trial ECOG-2100
Status: COMPLETED
Conditions: Breast Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: immunohistochemistry staining method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Customized Healing Abutments on Peri-implant Soft Tissue and Bone
Status: ENROLLING_BY_INVITATION
Conditions: Peri-implant Tissue Response With Use of Customized Healing Abutments
Interventions: PROCEDURE: customized healing abutment|PROCEDURE: standard healing abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab "
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cohort for Research and Innovation in Chronic Inflammatory Respiratory Diseases
Status: RECRUITING
Conditions: Chronic Inflammatory Pulmonary Diseases
Interventions: OTHER: Clinical assessment|BEHAVIORAL: questionnaires|OTHER: pulmonary function test|BIOLOGICAL: blood test|BIOLOGICAL: microbiology|BIOLOGICAL: histology|OTHER: imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact in Life Quality of a Educational Program for Prevention of Occupational Musculoskeletal Disorders in Workers
Status: COMPLETED
Conditions: Occupational Musculoskeletal Disorders|Healthy
Interventions: BEHAVIORAL: educational program|BEHAVIORAL: General education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Regorafenib in Combination With Metronomic Chemotherapies, and Low-dose Aspirin in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colo-rectal Cancer|Metastatic Cancer
Interventions: DRUG: Regorafenib|DRUG: Cyclophosphamide|DRUG: Capecitabine|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Prevention of Infections Related to Chambers Implantable Catheter by a Taurolodine Lock in Patients With Cancer Receiving Parenteral Nutrition
Status: UNKNOWN
Conditions: Cancer|Infection
Interventions: DEVICE: Taurolock|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Disease
Interventions: DIETARY_SUPPLEMENT: Soy isoflavones|DIETARY_SUPPLEMENT: cholecalciferol|DIETARY_SUPPLEMENT: Placebo of soy isoflavones|DIETARY_SUPPLEMENT: placebo of cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Extracorporeal Shockwave Therapy and Nutraceutical Supplementation in the Treatment of Epicondylitis: a Clinical Trial
Status: RECRUITING
Conditions: Epicondylitis, Lateral|Epicondylitis of the Elbow|Tennis Elbow
Interventions: OTHER: Extracorporeal Shockwave Treatment (Group A)|OTHER: Nutraceutical Supplementation (Group B)|OTHER: Combined Treatment (Group C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Lymphocyte Infusion in Treating Patients With Persistent, Relapsed, or Progressing Cancer After Donor Hematopoietic Cell Transplant
Status: COMPLETED
Conditions: Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Hodgkin Lymphoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Plasma Cell Myeloma
Interventions: BIOLOGICAL: Therapeutic Allogeneic Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP, an Autoimmune Disorder That Affects the Peripheral Nerves)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Interventions: BIOLOGICAL: Efgartigimod PH20 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Sedative Drugs for Conscious Sedation During Ultrasound Guided Transbronchial Needle Aspiration
Status: COMPLETED
Conditions: Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
Interventions: DRUG: midazolam|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Oral Epigallocatechin-3-gallate (EGCG) in IPF Patients
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: COMBINATION_PRODUCT: EGCG 300 mg + Nintedanib|COMBINATION_PRODUCT: EGCG 300 mg + Pirfenidone|COMBINATION_PRODUCT: Placebo 2 capsules + Nintedanib or Pirfenidone|COMBINATION_PRODUCT: EGCG 600 mg + Nintedanib|COMBINATION_PRODUCT: EGCG 600 mg + Pirfenidone|COMBINATION_PRODUCT: Placebo 4 capsules + Nintedanib or Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Breast Cancer|Head and Neck Squamous Cell Carcinoma|Melanoma|Non Small Cell Lung Cancer|Pancreatic Cancer|Liver Cancer
Interventions: BIOLOGICAL: YE-NEO-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Controlled Trial of Velafermin for Prevention of Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis|Stomatitis
Interventions: DRUG: velafermin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transumbilical Laparoscopic Appendectomy
Status: RECRUITING
Conditions: Appendicitis|Surgical Site Infection
Interventions: PROCEDURE: Transumbilical laparoscopic appendectomy + Glove finger technique|PROCEDURE: Standard transumbilical laparoscopic appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-assisted vs Landmark Based Intrathecal Administration of Nusinersen
Status: COMPLETED
Conditions: Muscular Atrophy, Spinal|Ultrasound
Interventions: DEVICE: US-assisted nusinersen administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effects of Tegaserod in the Management of Gastroesophageal Reflux Disease (GERD) in Patients With Incomplete Response to Proton Pump Inhibitors (PPIs).
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DRUG: Tegaserod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Immune Response to Vaccines and Ixekizumab (LY2439821) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ixekizumab|DRUG: Boostrix®|DRUG: Pneumovax®23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EFFECT OF SMOKING ON MUCUS HYPERSECRETION MECHANISMS IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Status: COMPLETED
Conditions: CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Interventions: PROCEDURE: bronchial biopsies|OTHER: Determination of CO in exhaled air
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Transcranial Direct Current Stimulation (tDCS) and Probiotic Supplementation in Overweight Adults
Status: RECRUITING
Conditions: Overweight and Obesity
Interventions: DRUG: Probiotic Blend Capsule|DEVICE: tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adenoma Detection Rate in Colonoscopy Performed With EndoRings
Status: TERMINATED
Conditions: Colorectal Adenoma|Colorectal Neoplasms
Interventions: DEVICE: EndoRings II Distal Attachment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Analysis of Naxitamab (hu3F8) in the Treatment of Pediatric High Risk or Refractory/ Relapsed Neuroblastoma
Status: RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: Naxitamab monotherapy|DRUG: GM-CSF|DRUG: Irinotecan|DRUG: Temozolomide|DRUG: Naxitamab in combination therapy|DRUG: GM-CSF with combination regimen|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Intervention With Únicla Dairy Products (DANTIAN)
Status: UNKNOWN
Conditions: Subclinical Hypothyroidism
Interventions: OTHER: Experimental milk|OTHER: Experimental yogur|OTHER: Experimental fresh cheese|OTHER: Placebo milk|OTHER: Placebo yogur|OTHER: Placebo fresh cheese
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: DETAIL Study: Diabetes Exposed to Telmisartan and Enalapril
Status: COMPLETED
Conditions: Hypertension|Diabetes Mellitus, Type 2
Interventions: DRUG: telmisartan|DRUG: enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Probiotic on LDL-cholesterol Levels
Status: COMPLETED
Conditions: Cardiovascular Diseases|LDL-cholesterol
Interventions: BIOLOGICAL: Bifidobacterium BSL_PS404|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline
Status: RECRUITING
Conditions: Cognitive Decline|Osteoarthritis
Interventions: OTHER: Healthy Body & Mind Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROmotion of FLU Vaccine Uptake in the Emergency Department - PROFLUVAXED
Status: COMPLETED
Conditions: Influenza Vaccination
Interventions: OTHER: Question (Q)|OTHER: Messaging (M)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CVM-1118 and Sorafenib Combination in Subjects With Advanced Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma|Advanced Cancer
Interventions: DRUG: Sorafenib|DRUG: CVM-1118
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Radiation Therapy vs. Watchful Waiting Following Radical Prostatectomy in High Risk Prostate Cancer
Status: UNKNOWN
Conditions: Prostatic Neoplasms
Interventions: RADIATION: Adjuvant radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR Evidence of Cardiac Inflammation Post-Stroke
Status: RECRUITING
Conditions: Stroke, Ischemic|Inflammation|Myocardial Injury
Interventions: DIAGNOSTIC_TEST: Gadolinium-enhanced cardiac MRI|DIAGNOSTIC_TEST: B Natriuretic Peptide|DIAGNOSTIC_TEST: Systemic inflammatory markers
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD
Status: COMPLETED
Conditions: Lung, Hyperlucent|Positive-Pressure Respiration, Intrinsic
Interventions: PROCEDURE: ventilation|PROCEDURE: excecise training|PROCEDURE: Both
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Melatonin on Sleep Quality in Patients Dementia
Status: COMPLETED
Conditions: Sleep Disorders|Dementia
Interventions: DRUG: Melatonin 5 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Immunogenicity of GlaxoSmithKline Biologicals' Herpes Zoster Vaccine 1437173A
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: Herpes Zoster Vaccine 1437173A|BIOLOGICAL: Placebo vaccine (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Phenobarbital Sodium Injection for the Treatment of Neonatal Seizures
Status: WITHDRAWN
Conditions: Neonatal Seizure
Interventions: DRUG: Phenobarbital Sodium Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Mouth-opening Training on the Maximum Interincisal Opening
Status: COMPLETED
Conditions: Oral Cancer
Interventions: BEHAVIORAL: The mouth-opening training with follow-up telephone calls program|BEHAVIORAL: The mouth-opening training without follow-up telephone calls program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1, Single-Dose and Multiple-Dose Continuous Intravenous Infusions of TNP-2092 for Injection in Healthy Chinese Participants
Status: COMPLETED
Conditions: Acute Bacterial Skin and Skin Structure Infection (ABSSSI)|Prosthetic Joints Infection (PJI)
Interventions: DRUG: TNP-2092 for injection|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Site Infiltration Using Ketamine Versus Bupivacaine for Analgesia in Post-operative Appendectomy Operation
Status: COMPLETED
Conditions: Appendicitis Acute
Interventions: DRUG: Ketamine Versus Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Investigating the Metabolic Activity and Transcriptional Profiling in Vivo in Tumor Biopsies in Melanoma Patients During Treatment With Pazopanib Alone and in Combination With Paclitaxel
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Pazopanib/Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Disclosure: A Combat-Specific PTSD Treatment
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Adaptive Disclosure (AD)|BEHAVIORAL: Cognitive Processing Therapy, cognitive version only (CPT-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Factors and Prevention of Severe Pain Upon Cessation of a Peripheral Nerve Block
Status: UNKNOWN
Conditions: Surgery
Interventions: DRUG: Ketalar, 5 mg/mL Injectable Solution|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Micronutrient Supplementation for Maternal Anemia Prevention in Tanzania
Status: NOT_YET_RECRUITING
Conditions: Pregnancy Related
Interventions: DIETARY_SUPPLEMENT: Multiple Micronutrient Supplements with 30 mg of elemental iron|DIETARY_SUPPLEMENT: Multiple Micronutrient Supplements with 45 mg of elemental iron|DIETARY_SUPPLEMENT: Multiple Micronutrient Supplements with 60 mg of elemental iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: DRUG: Ketorolac tromethamine|DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vorinostat After Stem Cell Transplant in Treating Patients With High-Risk Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer
Interventions: DRUG: vorinostat|OTHER: Correlative studies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy & Cost Effectiveness of Antimicrobial-impregnated CVCs in CLABSI Prevention in a Malaysia Adult ICU
Status: RECRUITING
Conditions: CLABSI - Central Line Associated Bloodstream Infection
Interventions: DEVICE: Arrow Three-Lumen Central Venous Catheter|DEVICE: Arrowg+ard Blue Plus® Three-Lumen Central Venous Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Cold Application on Nausea and Vomiting in the Early Postoperative Period
Status: RECRUITING
Conditions: Local Application/Packing Too Cold|Patient Satisfaction|Postoperative Nausea and Vomiting
Interventions: OTHER: Cold application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients Wtih Advanced Hematopoietic Malignancies
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|Myelodysplasia|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia|Multiple Myeloma|Lymphomas|Low-grade NHL and Chronic Lymphocytic Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DIETARY_SUPPLEMENT: 2-HOBA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Adaptive Radiotherapy and Multimodal Information of Cervical Cancer Assisted by Artificial Intelligence
Status: UNKNOWN
Conditions: Cervical Cancer|Radiotherapy Side Effect|Biomarker|Artificial Intelligence
Interventions: RADIATION: Adaptive radiotherapy|RADIATION: no adaptive radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction of Stent Associated Morbidity by Minimizing Stent Material.
Status: COMPLETED
Conditions: Ureteral Stent Related Morbidity
Interventions: DEVICE: ureteral stenting with standard or modified ureteral stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postoperative Consequences of Intraoperative NOL Titration
Status: COMPLETED
Conditions: Anesthesia; Adverse Effect
Interventions: DRUG: Routine opioid management|DEVICE: PMD-200 Nol-guided opioid administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pomegranate Products for Prevention of Common Cold
Status: COMPLETED
Conditions: Influenza|Common Cold|Cough|Headache|Fever
Interventions: DIETARY_SUPPLEMENT: Pomegranate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome
Status: RECRUITING
Conditions: T Cells|Colorectal Cancer|Lynch Syndrome
Interventions: DRUG: Naproxen|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Transdiagnostic Group Treatment for Emotional Disorders Applied in Blended Format: a Controlled Study.
Status: NOT_YET_RECRUITING
Conditions: Anxiety Disorders|Depressive Disorders
Interventions: BEHAVIORAL: Blended group transversal protocol (BLGr-TP)|BEHAVIORAL: Face-to-face group transversal protocol (FFGr-TP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manual Chest Physiotherapy and Active Cycle of Breathing Techniques (ACBT) in Patients of Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: MCPT|OTHER: ACBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT