pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase 2 Study of SPI-2012 or Pegfilgrastim for the Management of Neutropenia in Participants With Breast Cancer
Status: COMPLETED
Conditions: Neutropenia
Interventions: DRUG: SPI-2012|DRUG: Pegfilgrastim|DRUG: Docetaxel|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ProQuad in Healthy 4 to 6 Year Old Children (V221-014)
Status: COMPLETED
Conditions: Measles|Mumps|Rubella|Varicella
Interventions: BIOLOGICAL: ProQuad (Measles, Mumps, Rubella and Varicella (Oka-Merck) Virus Vaccine Live)|BIOLOGICAL: Comparator: M-M-R II|BIOLOGICAL: Comparator: Varivax|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Intervention Psychosis and Addiction
Status: UNKNOWN
Conditions: Psychosis|Substance Abuse
Interventions: BEHAVIORAL: Skills trainig for patients with dual diagnosis|BEHAVIORAL: regular treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Efficacy and Safety of Ginsenoside Rg3 Capsule in Prevention of Postoperative Recurrence of Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Stage I Hepatocellular Carcinoma|Stage II Hepatocellular Carcinoma
Interventions: DRUG: the ginsenoside Rg3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nitrate and Exercise Performance in Middle to Older Aged Adults
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: High Nitrate Beetroot Juice|DIETARY_SUPPLEMENT: Low Nitrate Beetroot Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of [14 C]-Pevonedistat in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors, Neoplasms, Advanced Solid
Interventions: DRUG: Pevonedistat|DRUG: [14C]-Pevonedistat|DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Eye Mask on Sleep Quality and Tear Layer Function in Patients With Dry Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease
Interventions: DEVICE: Eye mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of ALiskiren, a Direct Renin Inhibitor, in Preventing Atrial Fibrillation in Patients With a Pacemaker; RALF.
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Role of ClO2 on Mucositis for Pt. Undergoing Head/Neck Radiotherapy
Status: TERMINATED
Conditions: Head and Neck Carcinoma
Interventions: DRUG: Chlorine Dioxide Sterilization|OTHER: Laboratory Biomarker Analysis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Status: RECRUITING
Conditions: Depressive Disorder|Major Depressive Disorder|Bipolar Disorder|Post Traumatic Stress Disorder|Suicidal Ideation
Interventions: DRUG: Perampanel 6 MG|DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs)
Status: RECRUITING
Conditions: Vascular Access Complication|Device Related Infection|Device Related Sepsis|Device Site Reactions|Catheter Infection|Catheter Complications|Catheter-Related Infections|Catheter Related Complication|Occlusive Dressings|Wound Infection|Wound of Skin|Wound
Interventions: DEVICE: Chlorhexidine gluconate impregnated bordered polyurethane dressing|DEVICE: Standard bordered polyurethane dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Recurrence in Buccinator Muscle Excision With the Skin Versus Without the Skin in Buccal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of the Oral Cavity
Interventions: PROCEDURE: surgical excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomics IND EXEMPT SNP Clinical Study - Etoposide and Single Nucleotide Polymorphisms
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Cancer
Interventions: DRUG: ETOPOSIDE - Usual|DRUG: ETOPOSIDE - Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Buteyko Breathing Technique on Asthma Control and Quality of Life in Children With Asthma
Status: RECRUITING
Conditions: Asthma in Children
Interventions: BEHAVIORAL: BUTEYKO RESPIRATORY TECHNIQUE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Human Umbilical Cord-derived Mesenchymal Stem Cells for Treatment of Refractory Immune Thrombocytopenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Thrombocytopenia|Mesenchymal Stem Cells
Interventions: OTHER: Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study Between Fluticasone Propionate 100 mcg and Salmeterol Xinafoate 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 100/50 Inhalation Powder/GSK in Healthy Volunteers
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Test Product|DRUG: Reference Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Orteronel Maintenance Therapy in Patients With Metastatic Castration Resistant Prostate Cancer and Non-progressive Disease After First-line Docetaxel Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Orteronel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD5 CAR-T Therapy for Refractory/Relapsed CD5+ T-cell Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: T-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: CD5 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Crenolanib in Combination With Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia and Activating FLT3 Mutations
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: chemotherapy (Mitoxantrone, Cytarabine)|DRUG: Placebo|DRUG: Crenolanib|OTHER: Allogeneic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Transversus Abdominis Plane Block (LTAP) for Appendicectomy Versus Standard Port Site Treatment
Status: UNKNOWN
Conditions: Pain|Appendicitis|Surgery|Analgesia|Laparoscopic|Bupivacaine
Interventions: OTHER: Tap Block - Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NAV-ALI: Neurally Adjusted Ventilatory Assist in Patients Recovering Spontaneous Breathing After Acute Lung Injury
Status: COMPLETED
Conditions: Acute Lung Injury|Mechanical Ventilation
Interventions: DEVICE: PSV - pressure suppot ventilation|DEVICE: NAVA - Neurally Adjusted Ventilatory Assist|DEVICE: NAVA - EMG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long Term Follow Up for RAD001 Therapy of Angiomyolipomata in Patients With Tuberous Sclerosis (TSC) and Sporadic Lymphangioleiomyomatosis (LAM)
Status: COMPLETED
Conditions: Tuberous Sclerosis|Angiolipoma
Interventions: DRUG: everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study
Status: RECRUITING
Conditions: Traumatic Brain Injury|Subarachnoid Hemorrhage|Brain Injuries|Near-Infrared Spectroscopy|Intensive Care Neurological Disorder|Anemia
Interventions: OTHER: Near-infrared spectroscopy (NIRS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of One Tablet of Paracetamol 1000 mg + Codeine 30 mg vs. Two Tablets of Paracetamol 500 mg + Codeine 30 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Paracetamol 1000 mg/codeine phosphate hemihydrate 30 mg tablet|DRUG: Paracetamol 500 mg/codeine phosphate hemihydrate 30 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells
Status: COMPLETED
Conditions: Infertility|Asherman Syndrome
Interventions: DEVICE: collagen/ABMNC scaffold|DEVICE: Foley catheter balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor
Status: TERMINATED
Conditions: Obstetric Labour, Premature
Interventions: DRUG: Retosiban IV infusion|DRUG: Placebo IV infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Post-operative Antibiotic Prophylaxis for Thoracic Surgery Requiring Tube Thoracostomy
Status: COMPLETED
Conditions: Antibiotic Prophylaxis
Interventions: DRUG: cefazolin or vancomycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind,Dose-escalating, Single-dose, Oral Phase I Clinical Study of Flunotinib Healthy People
Status: RECRUITING
Conditions: Healthy Person
Interventions: DRUG: flunotinib|DRUG: flunotinib placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Microsurgery vs Diode Laser Technique of Gingival Depigmentation
Status: NOT_YET_RECRUITING
Conditions: Gingival Pigmentation|Melanosis
Interventions: PROCEDURE: Gingival depigmentation using microsurgery|PROCEDURE: Gingival Depigmentation using Diode Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cirrhotic Cardiomyopathy Based on Point-of-care Echocardiography, Biomarkers and Histology
Status: RECRUITING
Conditions: Cirrhotic Cardiomyopathy|Cirrhosis, Liver|Cardiac Disease
Interventions: DEVICE: Echocardiographic assessment|DIAGNOSTIC_TEST: Histopathology and Immunohistochemistry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DaxibotulinumtoxinA Injection for Treatment of Adductor Spasmodic Dysphonia
Status: ACTIVE_NOT_RECRUITING
Conditions: Adductor Spasmodic Dysphonia|Voice Disorders|Spasmodic Dysphonia
Interventions: DRUG: DaxibotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Analgesia After ACL Reconstruction
Interventions: DRUG: 0.25% Bupivacaine|DRUG: 0.5% Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Epoetin Alfa on the Anemia of Patients With Selected Cancers Receiving Chemotherapy
Status: COMPLETED
Conditions: Anemia|Multiple Myeloma|Lymphoma|Breast Cancer|Ovarian Cancer|Carcinoma, Small Cell Lung|Esophagus Cancer|Prostate Cancer|Neoplasm
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Pharmacokinetics Study of Niraparib Plus an Androgen Receptor-Targeted Therapy in Men With Metastatic Castration-Resistant Prostate Cancer (BEDIVERE)
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Niraparib|DRUG: Apalutamide|DRUG: Abiraterone Acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension Associated With Connective Tissue Disease
Interventions: DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel Compared With Docetaxel in the Neoadjuvant Chemotherapy Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Chemotherapy Effect
Interventions: DRUG: Nab paclitaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Potential of Light Therapy in Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: DEVICE: White LED light|DEVICE: Green LED light
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation if Physostigmine Reduces Symptoms in Patients Who Has Developed a Delirium in Intensive Care After a Surgery
Status: UNKNOWN
Conditions: Suspected Delirium After Elective or Emergency Heart Surgery|CAM-ICU Diagnosed Delirium
Interventions: DRUG: Physostigmine|OTHER: Sodium Chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Pirfenidone in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction
Status: COMPLETED
Conditions: Cardiac Failure
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Radiotherapy Versus Observation After Radical Cystectomy in High Risk Urothelial Bladder Cancer
Status: UNKNOWN
Conditions: High-Risk Cancer|Urothelial Carcinoma Bladder
Interventions: RADIATION: Adjuvant Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adolescent Substance Use Prevention Intervention Research Study in Pediatric Primary Care
Status: RECRUITING
Conditions: Heavy Drinking|Driving Under the Influence|Riding With Driver Under the Influence
Interventions: BEHAVIORAL: Computer-facilitated Screening and Brief Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux Valve
Status: TERMINATED
Conditions: Biliary Obstruction|Cholangitis
Interventions: DEVICE: Cook´s biliary stent with an antireflux stent, normal biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Controlled Study of Popofol Versus Midazolam as Sedation in Endoscopy With Advanced Liver Disease.
Status: UNKNOWN
Conditions: Liver Diseases
Interventions: DRUG: Propofol|DRUG: Midazolam|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized, Open-Label, Crossover Study to Evaluate the Pharmacokinetic Profiles of Rotigotine After a Single Dose of LY03003 (28 mg) Versus After a Week of Daily NEUPRO® Transdermal Patch (4 mg Every 24 Hours) in Healthy Volunteers
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: LY03003 (rotigotine extended release microspheres for intramuscular [IM] injection)|OTHER: Neupro 4 mg / 24 Hr. Transdermal Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gender Solutions Natural Knee Post-Market Study
Status: WITHDRAWN
Conditions: Osteoarthritis|Inflammatory Arthritis|Post-traumatic Arthritis|Rheumatoid Arthritis|Osteonecrosis|Varus or Valgus Deformities
Interventions: DEVICE: Zimmer Gender(R) Solutions(TM) Natural-Knee(R) Flex System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Study With Carfilzomib and Dexamethasone Versus Bortezomib and Dexamethasone for Relapsed Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of ICP-332 in Healthy Subjects
Status: RECRUITING
Conditions: Healthy Subjects
Interventions: DRUG: ICP-332 Tablets|DRUG: ICP-332 Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Status: RECRUITING
Conditions: Obesity|Overweight|Knee Pain Chronic|Knee Osteoarthritis|Obstructive Sleep Apnea
Interventions: DRUG: Retatrutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
Status: RECRUITING
Conditions: Multiple Myeloma|Stem Cell Transplant Complications
Interventions: BEHAVIORAL: PARE|BEHAVIORAL: Waitlist Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Insulin Detemir With Insulin Glargine in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin glargine|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Daily Disposable Contact Lenses for Wearers With Astigmatism
Status: COMPLETED
Conditions: Astigmatism|Myopia
Interventions: DEVICE: Nelfilcon A investigational contact lens|DEVICE: Nelfilcon A commercial contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Digital Health Application (Lipodia) on LDL-cholesterol Levels
Status: NOT_YET_RECRUITING
Conditions: Hypercholesterolemia|Dyslipidemias
Interventions: BEHAVIORAL: lipodia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Hetrombopag in Primary Prevention of Thrombocytopenia Induced by the Niraparib Maintenance in Advanced Ovarian Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Thrombocytopenia
Interventions: DRUG: Hetrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BGB-B3227 Alone and in Combination With Tislelizumab in Participants With Advanced or Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Cancer|Advanced Solid Tumor|Metastatic Cancer|Metastatic Solid Tumor
Interventions: DRUG: BGB-B3227|DRUG: Tislelizumab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: LGX818|DRUG: MEK162|DRUG: LEE011|DRUG: BGJ398|DRUG: BKM120|DRUG: INC280
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
Status: RECRUITING
Conditions: Sickle Cell Disease|Thalassemia|Stem Cell Transplantation|Graft vs Host Disease
Interventions: DRUG: Alemtuzumab|DRUG: Sirolimus|DRUG: Cyclophosphamide|DRUG: Pentostatin|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy, Duration of Remission and Safety of a Light and Occlusive Patch Therapy for Plaque Psoriasis
Status: UNKNOWN
Conditions: Psoriasis
Interventions: DEVICE: Luma Light System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Enhancement Training Study for Novice Shiftworkers
Status: COMPLETED
Conditions: Shift-Work Sleep Disorder
Interventions: BEHAVIORAL: Sleep Enhancement Training System|BEHAVIORAL: NIOSH shiftwork booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis HBsAg Test at the Point-Of-Care Sites
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatitis B|Hepatitis B Infection
Interventions: DEVICE: iStatis HBsAg Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Connecting Women to Care: Home-based Psychotherapy for Women With MST Living in Rural Areas
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Skills Training in Affective and Interpersonal Regulation|BEHAVIORAL: Present Centered Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Randomized Phase II Adjuvant Chemotherapy ± FANG™ in Colorectal Carcinoma With Liver Metastases
Status: TERMINATED
Conditions: Colon Cancer
Interventions: BIOLOGICAL: Vigil™ Vaccine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD.
Status: NOT_YET_RECRUITING
Conditions: Daily Step Count|MASLD|BMI|Metabolic Syndrome|NAFLD|Insulin Resistance|Genetic Polymorphism|Cardiovascular Disease (CVD)
Interventions: OTHER: Encourage using pedometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of a School-based Intervention to Improve the Wellbeing of Children Aged 10 to 13 Years.
Status: RECRUITING
Conditions: Well-Being, Psychological|Child, Only
Interventions: BEHAVIORAL: A Lust for Life|BEHAVIORAL: Waiting List Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ten Years Results of a Score System to Address Adjuvant Therapies After Breast Conserving Surgery for Ductal Carcinoma in Situ of the Breast
Status: COMPLETED
Conditions: Carcinoma Breast
Interventions: PROCEDURE: Breast conservative surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Compares Pneumothorax Recurrence: Absorbable Mesh vs. Pleurectomy in Primary Spontaneous Pneumothorax.
Status: RECRUITING
Conditions: Primary Spontaneous Pneumothorax
Interventions: PROCEDURE: Partially absorbable mesh|PROCEDURE: Apical pleurectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Portable Diagnostic Device for Automatic Detection of Relative Afferent Pupillary Defect
Status: COMPLETED
Conditions: Multiple Sclerosis|Glaucoma
Interventions: DEVICE: O-Glass|OTHER: Swinging Flashlight Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer|Self Efficacy
Interventions: BEHAVIORAL: PATHWAYS|OTHER: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Novel Approach for Transjugular Intrahepatic Portocaval Shunt Creation Using Real-time Three Dimensional Roadmap
Status: COMPLETED
Conditions: Portal Hypertension
Interventions: OTHER: 3d roadmap guidance|OTHER: conventional TIPS procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Trial Protocol for the Inactivated Poliomyelitis Vaccine Made From Sabin Strains(Sabin IPV)
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Inactivated Poliomyelitis Vaccine (Sabin strains)|BIOLOGICAL: Inactivated Poliomyelitis Vaccine (Salk strains)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bone Health in Aging HIV Infected Women
Status: COMPLETED
Conditions: Osteoporosis|HIV|Menopause
Interventions: DRUG: tenofovir-alafenamide-emtricitabine|DRUG: tenofovir-emtricitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study Of Long-Term Safety And Efficacy Of Pregabalin As Monotherapy (Lyrica) In Patients With Partial Seizures
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparasion of Efficacy of Nebulized With Intravenous Magnesium Sulphate in Children With Asthma
Status: COMPLETED
Conditions: Asthma in Children
Interventions: DRUG: Nebulized Magnesium sulfate|DRUG: Intravenous magnesium sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Mechanical Nerve Stimulation in the Treatment of Incontinence
Status: TERMINATED
Conditions: Stress Urinary Incontinence|Urge Urinary Incontinence
Interventions: DEVICE: Transcutaneous mechanical nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Difference in the Metabolic Characteristics of COPD Patients and Healthy Adults
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Functional near infrared spectroscopy|PROCEDURE: Moxibustion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Interaction Between Etravirine or Darunavir/Ritonavir and Artemether / Lumefantrine
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Etravirine|DRUG: Darunavir/ritonavir|DRUG: artemether/lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Acoustic Attenuation Parameter Using FibroTouch With Liver Biopsy for Diagnosis of Hepatic Steatosis
Status: UNKNOWN
Conditions: Fatty Liver|Hepatic Steatosis|Liver Steatosis
Interventions: DEVICE: FibroTouch|PROCEDURE: Liver Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON)
Status: COMPLETED
Conditions: Optic Neuritis|Multiple Sclerosis|Encephalopathy
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcitriol in Preventing Prostate Cancer in Patients With Prostatic Intraepithelial Neoplasia
Status: TERMINATED
Conditions: Precancerous/Nonmalignant Condition|Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: calcitriol|PROCEDURE: observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: OTHER: Acute Intermittent Hypoxia (AIH)|BEHAVIORAL: Upper extremity training|OTHER: Sham Acute intermittent hypoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Campath-1H Induction Therapy Combined With CellCept® Therapy to Allow for a Calcineurin Inhibitor Free Regimen After Renal Transplantation
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Campath 1H®, Rituximab, mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Customized Foot Orthoses With Orthotic Wedges for Plantar Heel Pain
Status: NOT_YET_RECRUITING
Conditions: Foot Orthoses|Fasciitis, Plantar
Interventions: DEVICE: orthotic wedge|DEVICE: CFO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting a Web-Based Professional Development for Mexican School Mental Health Providers Delivering Evidence-Based Intervention for ADHD and ODD
Status: COMPLETED
Conditions: ADHD|Oppositional Defiant Disorder
Interventions: BEHAVIORAL: CLS-R-FUERTE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph1 Administration of VSV-IFNβ-NIS Monotherapy and in Combination With Avelumab in Pts With Refractory Solid Tumors
Status: COMPLETED
Conditions: Malignant Solid Tumour
Interventions: BIOLOGICAL: VSV-IFNβ-NIS|BIOLOGICAL: VSV-IFNβ-NIS and avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Self-Acupressure on Peripheral Neuropathic Pain and HbA1c
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Self-Acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Body Composition Measurements in Chronic Heart Failure
Status: UNKNOWN
Conditions: Cachexia|Sarcopenia|Body Composition
Interventions: DEVICE: bioelectrical impedance analysis (Bodystat, Quadscan 4000)|DEVICE: dual-energy X-ray absorptiometry (Hologic, Delphi QDR)|DEVICE: hand grip strength
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Mass Balance of [14C] ABBV-552 in Healthy Male Participants Following Single Oral Dose Administration
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: ABBV-552
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lactobacillus Kefiri LKF01 (DSM32079) in Newborns Born by Caesarian Section
Status: UNKNOWN
Conditions: Caesarean Section;Stillbirth|Microbial Colonization
Interventions: DIETARY_SUPPLEMENT: Lactobacillus kefiri LKF01 DSM32079|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Preschoolers' Mental Health: A RCT Assessing Two Parenting Programs
Status: RECRUITING
Conditions: Mental Health Issue|Parenting
Interventions: BEHAVIORAL: How-to talk so kids will listen and listen so kids will talk|BEHAVIORAL: Nobody's Perfect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dezocine for Prevention of Catheter-related Bladder Discomfort
Status: COMPLETED
Conditions: Catheter Related Bladder Discomfort
Interventions: DRUG: Dezocine|DRUG: Flurbiprofen Axetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of the Use of a Closed-loop Insulin Therapy on the Burden of the Diabetes and the Quality of Life
Status: UNKNOWN
Conditions: Quality of Life|Burden, Dependency
Interventions: DEVICE: Activation of a closed loop device in an insulin pump device with GCM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Neuromuscular Electrical Stimulation for Quadriceps and Triceps During Pulmonary Rehabilitation in COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease Overlap Syndrome|Asthma
Interventions: DEVICE: Neuromuscular Electrical Stimulation|DEVICE: Sham Neuromuscular Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Gene Signatures to Guide HR+MBC Therapy in a Diverse Cohort
Status: RECRUITING
Conditions: Invasive Mammary Carcinoma|Metastatic Breast Cancer
Interventions: DRUG: Capecitabine|OTHER: Endocrine-therapy|OTHER: MammoPrint ® and BluePrint assays
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
Status: NOT_YET_RECRUITING
Conditions: THC
Interventions: DRUG: THC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Assessing the Impact of Elelyso on Bone Involvement Currently Treated With Other ERTs
Status: COMPLETED
Conditions: Gaucher Disease, Type 1
Interventions: PROCEDURE: quantitative chemical shift imaging (QCSI)|DRUG: Elelyso
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility of Exoskeleton Robot Training in Patients With Septic Arthritis After a Thermal Injury: A Case Report
Status: NOT_YET_RECRUITING
Conditions: Septic Arthritis|Gait Disorder, Sensorimotor
Interventions: OTHER: robot assisted training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inulin and S. Salivarius Reduce Halitosis
Status: COMPLETED
Conditions: Halitosis|Tongue Diseases
Interventions: DRUG: Inulin+SS|DRUG: S salivarius|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Gait Biomechanics for Posttraumatic Osteoarthritis Prevention
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries|Post-traumatic Osteoarthritis|Knee Osteoarthritis|Knee Injuries|Cartilage, Articular|Gait
Interventions: BEHAVIORAL: Real-time gait biofeedback|BEHAVIORAL: Sham real-time gait biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Pergoveris in Aged IVF Patients
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Pergoveris (FSH and LH)|DRUG: Follitropin alpha (FSH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Cryosurgery and NK Immunotherapy for Recurrent Sarcoma
Status: COMPLETED
Conditions: Recurrent Adult Soft Tissue Sarcoma
Interventions: DEVICE: Cryosurgery|BIOLOGICAL: NK immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FRAMED Infrainguinal Venous Bypass Versus Conventional Autologous Bypass Trial
Status: RECRUITING
Conditions: Peripheral Arterial Occlusive Disease|Femoropopliteal Artery Occlusion|Femoropopliteal Stenosis|Critical Limb-Threatening Ischemia|Claudication, Intermittent
Interventions: PROCEDURE: FRAMED Infrainguinal Venous Bypass|PROCEDURE: Conventional Autologous Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplantation for Patients With Severe Aplastic Anemia
Status: COMPLETED
Conditions: Anemia, Aplastic
Interventions: DRUG: Cyclophosphamide,Campath IH and TBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topotecan in Treating Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: DRUG: Olaparib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donepezil Trial for Motor Recovery in Acute Stroke
Status: WITHDRAWN
Conditions: Acute Stroke
Interventions: DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triple in Asthma Dose Finding
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF 5259 plus Foster 100/6 µg|DRUG: Foster 100/6 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Mechanistic Effects of Dapagliflozin Alone or in Combination With Balcinrenone, Compared to Balcinrenone and Placebo on Body Fluid and Electrolyte Handling and Energy Metabolism in Participants Over 50 Years of Age With Chronic Kidney Disease.
Status: RECRUITING
Conditions: Chronic Renal Failure|Mechanistic Effects of SGLT2 Inhibition and/ or MR Antagonism on Body Fluid and Electrolyte Homeostatis
Interventions: DRUG: Dapagliflozin 10mg Tab|DRUG: Balcinrenone 50mg Capsule|DRUG: Balcinrenone 100mg Capsule|DRUG: Dapagliflozin matching Placebo|DRUG: Balcinrenone 50mg matching Placebo|DRUG: Balcinrenone 100mg matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Calcitriol Monotherapy for X-Linked Hypophosphatemia
Status: RECRUITING
Conditions: X-linked Hypophosphatemia|Hypophosphatemic Rickets|Hypophosphatemic Rickets, X-Linked Dominant
Interventions: DRUG: Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Randomized Phase III Study Comparing Hormonal Therapy +/-Docetaxel
Status: UNKNOWN
Conditions: Adenocarcinoma of the Prostate
Interventions: DRUG: Docetaxel + hormonal treatment (LH-RH agonist)|DRUG: Hormonal treatment (LH-RH agonist)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postural Drainage With and Without Aerobic Training on Chronic Suppurative Lung Disease
Status: COMPLETED
Conditions: Lung Disease Chronic
Interventions: OTHER: Postural Drainge and aerobic training|OTHER: Postural Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of the Minimally Invasive Coronary Artery Bypass Grafting
Status: UNKNOWN
Conditions: Coronary Artery Disease|Myocardial Ischemia|Heart Diseases
Interventions: PROCEDURE: MICS CABG|PROCEDURE: OPCABG|PROCEDURE: ONCABG|DEVICE: Octopus® Nuvo, Starfish® Non-Sternotomy, thoracic retractor (ThoraTrak®)|DEVICE: Starfish®, Octopus®, Clearview® blower, ClearView® Shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Test How Effective and Safe GLPG1690 is for Participants With Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: GLPG1690|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Immunogenicity of a Single Dose of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) in Older Adults in Turkey and Lebanon
Status: COMPLETED
Conditions: Healthy Volunteers (Meningococcal Infection)
Interventions: BIOLOGICAL: Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid conjugate vaccine MenACYW conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6)
Status: COMPLETED
Conditions: Renal Failure|Impaired Renal Function
Interventions: DRUG: 600 mg linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Predictive Genetic Risk Assessment Trial
Status: COMPLETED
Conditions: Colon Cancer|Lung Cancer|Atrial Fibrillation|Diabetes Type 2|Obesity|Breast Cancer|Graves Disease|Osteoarthritis|Celiac Disease|Myocardial Infarction|Prostate Cancer
Interventions: GENETIC: SNP analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Validity of Smart Cap and Smart Sweat Patch
Status: COMPLETED
Conditions: Fluid Intake in Athletes|Sweating Rate in Athletes|Sweat Chloride Concentration in Athletes
Interventions: DEVICE: Smart Cap, running and fitness exercisers only|DEVICE: Sweat Patch, all subjects- running, fitness, cycling|DEVICE: Reference sweat patch, all subjects - running, fitness, cycling|OTHER: Bottle Scale, all subjects - running, fitness, cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Validation Study of a Watch for the Detection of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Arrythmia, Cardiac
Interventions: DIAGNOSTIC_TEST: AF detection by ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC