pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of CC-90010 in Subjects With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin's Lymphomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, Non-Hodgkin|Neoplasms
Interventions: DRUG: CC-90010
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Doses and Duration of Low Molecular Weight Heparin (Parnaparin)in Superficial Vein Thrombosis
Status: COMPLETED
Conditions: Thrombophlebitis
Interventions: DRUG: LMWH parnaparin subcutaneously
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of SAR443820 on Serum Neurofilament Levels in Male and Female Adult Participants With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: SAR443820|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Preoperative Single-dose Methylprednisolone on the Postoperative Rehabilitation After Abdominal Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy|Methylprednisolone|Postoperative Pain
Interventions: DRUG: Methylprednisolone 125mg|DRUG: Sodium Chloride 2 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Safety, Tolerability, PK and PD of AZD2373 in Healthy Male Participants of Sub-Saharan West African Ancestry
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD2373 subcutaneous injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Roflumilast TMS-EEG Plasticity
Status: WITHDRAWN
Conditions: Synaptic Plasticity
Interventions: DEVICE: Transcranial Magnetic Stimulation|DRUG: Roflumilast|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Neuromuscular Block and Arterial PCO2 on Surgical Rating Scale (SRS), Following Reversal With Sugammadex
Status: COMPLETED
Conditions: Prostate Cancer|Renal Cancer
Interventions: OTHER: hypocapnia|OTHER: normocapnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immune Response of Different Pediatric Combination Vaccines.
Status: COMPLETED
Conditions: Diphtheria|Polio|Pertussis
Interventions: BIOLOGICAL: DAPTACEL®. (DTaP), IPOL®., and ActHIB®.|BIOLOGICAL: Pentacel®: DTaP-IPV/Hib combined|BIOLOGICAL: DTaP-IPV and ActHIB®|BIOLOGICAL: Pentacel®: DTaP-IPV/Hib combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation for Hallucinations in First-Episode Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia|Schizophreniform|Schizoaffective Disorder|Psychosis Not Otherwise Specified (NOS)
Interventions: DRUG: Risperidone|DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gadobutrol Enhanced MRA of the Supra-aortic Vessels
Status: COMPLETED
Conditions: Carotid Stenosis
Interventions: DRUG: Gadobutrol (Gadovist, BAY86-4875)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Association Between Vitamin D and the Risk of Uterine Fibroids
Status: UNKNOWN
Conditions: Gynaecological Disease|Vitamin D Deficiency|Uterine Fibroids
Interventions: DRUG: Vitamin D3 400 UNT Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Treatment of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain
Status: COMPLETED
Conditions: Melanoma and Brain Metastases
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Gardasil (V501) in Preadolescents and Adolescents (V501-018)
Status: COMPLETED
Conditions: Human|Papillomavirus Infections
Interventions: BIOLOGICAL: V501|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Effect Study Between Distal-proximal Point Association and Local Distribution Point Association in Chemotherapy-induced Nausea and Vomiting
Status: UNKNOWN
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: only antiemetic (Ramosetron, Tropisetron and dexamethasone)|OTHER: Matching points ST36+CV12 plus antiemetic drug|OTHER: Matching points PC6+CV12 plus antiemetic drug|OTHER: Matching points CV13+CV12 plus antiemetic drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority of Ultrasound for the Diagnosis of Upper Extremity Fractures in Children
Status: COMPLETED
Conditions: Pediatric Fracture Diagnosis by Ultrasound Compared to X-ray
Interventions: DIAGNOSTIC_TEST: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Investigate the Pharmacokinetics of CHF 6001 DPI Administered Via Nexthaler® Device or the Capsule for Oral Inhalation Via Aerolizer® Device
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: CHF 6001 dry powder for inhalation via NEXThaler®|DEVICE: CHF 6001 DPI capsules for inhalation via Aerolizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Combination of Ibrutinib With Nivolumab in Participants With Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Neoplasms
Interventions: DRUG: Ibrutinib|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot Walking Rehabilitation in Stroke Patients
Status: TERMINATED
Conditions: Stroke|Gait Disorders, Neurologic
Interventions: DEVICE: Robot-assisted walking|DEVICE: Treadmill Training|OTHER: Ground treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ESM Versus OM ：A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Endoscopic Subcutaneous Mastectomy
Interventions: PROCEDURE: subcutaneous mastectomy|PROCEDURE: endoscopic subcutaneous mastectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMC125-TiDP35-C213: Safety and Antiviral Activity of Etravirine (TMC125) in Treatment-Experienced, HIV Infected Children and Adolescents
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: Etravirine (TMC125)|DRUG: Optimized background regimen (OBR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeatability, Reproducibility and Comparison of Cirrus OCT, RTVue OCT, MS-39 OCT, and Insight 100 VHFDU
Status: SUSPENDED
Conditions: Corneal Thickness Measurement|Epithelial Thickness Measurement|LASIK Flap Thickness Measurement|SMILE Cap Thickness Measurement
Interventions: DEVICE: ArcScan Insight 100 very high-frequency digital ultrasound|DEVICE: Carl Zeiss Meditec Cirrus HD OCT 5000|DEVICE: Optovue RTVue OCT|DEVICE: CSO MS-39 OCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Role of a Natural Product, Containing Nanovesicles From Citrus Limon (L.) Juice, on Different CV Risk Factors
Status: UNKNOWN
Conditions: Metabolic Syndrome|Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Natural supplement containing nanovesicles delivered from Citrus Limon (L.) juice_MetS|DIETARY_SUPPLEMENT: Placebo (without any active ingredients)|DIETARY_SUPPLEMENT: Natural supplement containing nanovesicles delivered from Citrus Limon (L.) juice_HS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Natural Killer (NK) Cell Therapy for B-Cell Malignancies
Status: RECRUITING
Conditions: B-cell Lymphoma|B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: QN-019a|DRUG: Rituximab|DRUG: Cyclophosphamid|DRUG: Fludarabine|DRUG: VP-16
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent Treatment for Substance Dependent Individuals With Post-Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Substance-Related Disorders
Interventions: BEHAVIORAL: Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure|BEHAVIORAL: Relapse Prevention Treatment|BEHAVIORAL: Active Monitoring Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L-Arginine, Vascular Response and Mechanisms
Status: COMPLETED
Conditions: Hypertension|Diabetes
Interventions: DIETARY_SUPPLEMENT: L-Arginine|DIETARY_SUPPLEMENT: Placebo Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diagnosis of Pheochromocytoma
Status: RECRUITING
Conditions: Pheochromocytoma|Endocrine Disease|Endocrine Diseases
Interventions: DRUG: ([18F]-DOPA)|DRUG: ([18F]-6F-DA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SPIRIT IV Clinical Trial: Clinical Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: XIENCE V® Everolimus Eluting Coronary Stent|DEVICE: TAXUS™ EXPRESS2™ Paclitaxel Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ex Vivo Transformation of White Adipose Tissue (WAT) Into Brown Adipose Tissue (BAT) in Morbidly Obese Patients Using the Ex Vivo Adipocyte Expansion (ExAdEx) Approach: Proof of Concept. From White to Brown Adipose Tissue
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Envafolimab Combined With Endostatin in Recurrent or Metastatic MSS-type Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DRUG: Envafolimab|DRUG: recombinant human endostatin (endostatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Fecal microbiota transplantation capsules|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy
Status: UNKNOWN
Conditions: Ventilator Lung|Liver Cirrhosis|Hepatocellular Carcinoma|Blood Loss, Surgical
Interventions: PROCEDURE: conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group|PROCEDURE: low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Interfascial Plane Block Versus Thoracic Paravertebral Block in Gynecomastia Surgery
Status: COMPLETED
Conditions: Gynecomastia|Thoracic Interfascial Plane Block|Thoracic Paravertebral Block|Anesthesia
Interventions: DRUG: Tumescent local anesthesia|DRUG: Thoracic paravertebral block|DRUG: Thoracic interfascial plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of TRC041266 in Patients With Heart Failure, LVEF ≥40%, Diastolic Dysfunction and Type 2 Diabetes Mellitus
Status: WITHDRAWN
Conditions: Chronic Stable Heart Failure
Interventions: DRUG: TRC041266|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot-trial Testing Remote Sleep Apnea Evaluation in Patients With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation|Sleep Apnea
Interventions: DEVICE: NightOwl home-monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparative Effects of a2 Skim Milk on Mild Cognitive Impairment in Older Adults
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Adults
Interventions: OTHER: a2Milk skim milk powder|OTHER: Yili skim milk powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of NSRCT on HbA1c and Inflammatory Markers in Healthy and Type 2 Diabetes Patients With Apical Periodontitis
Status: ACTIVE_NOT_RECRUITING
Conditions: PERIAPICAL LESIONS
Interventions: PROCEDURE: Nonsurgical root canal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Counseling to Reduce Children's SHS Exposure: A Trial With Maternal Smokers
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: BEHAVIORAL: Behavioral Counseling|BEHAVIORAL: Self-help control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation (RFA) Of Tumors Acquired In Childhood
Status: SUSPENDED
Conditions: Neoplasms, Benign|Neoplasms, Malignant
Interventions: PROCEDURE: Radiofrequency ablation (RFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prismaflex HF20 Set and Prismaflex® System 7.10/7.20 for Acute Continuous Renal Replacement Therapy (CRRT) in Children
Status: TERMINATED
Conditions: Acute Kidney Injury in Pediatric Patients
Interventions: DEVICE: Prismaflex HF20 CRRT Filter|DEVICE: Prismaflex® System 7.10 and 7.20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment of Carpal Tunnel Syndrome: Local Anesthesia With Epinephrine x Intravenous Regional Anesthesia.
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Anesthesia
Interventions: PROCEDURE: Intravenous regional anesthesia (Bier)|PROCEDURE: Local anesthesia with adrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Effects of Pharmaton Tablets on Mental Performance and Physical Fatigue in Nurses Working Night Shift
Status: COMPLETED
Conditions: Sleep Disorders, Circadian Rhythm
Interventions: DRUG: Pharmaton® Caplets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)
Status: RECRUITING
Conditions: Nonvalvular Atrial Fibrillation|Severe Degenerative Mitral Regurgitation
Interventions: PROCEDURE: MitraClip TMVR and Watchman LAAO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Substitution of Out-of-hours Care From General Practitioners to Nurse Practitioners
Status: COMPLETED
Conditions: Out-of-hours Care Services|Primary Healthcare
Interventions: OTHER: care provided by Nurse Practitioners
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reducing In-Hospital and 60-Day Mortality in ICU Patients After Surgery With Strict Nutritional Supplementation
Status: COMPLETED
Conditions: Protein-Energy Malnutrition
Interventions: DIETARY_SUPPLEMENT: Active nutritional supplementation|DIETARY_SUPPLEMENT: Conventional nutritional supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-2206 in Combination With Trastuzumab and Lapatinib for the Treatment of HER2+ Solid Tumors (MK-2206-015)
Status: TERMINATED
Conditions: Advanced Solid Tumors|Breast Cancer
Interventions: DRUG: MK-2206|BIOLOGICAL: Trastuzumab|DRUG: Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Parallel Group Trial Of The Efficacy And Safety Of Ezetimibe With A Statin Versus Statin Dose Doubling In Patients With Persistent Primary Hypercholesterolemia (0653-152)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe|DRUG: statins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Moderate Altitude Training on Metabolic Parameters in Voluntary Study Participants With Metabolic Syndrome
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: OTHER: 2 weeks of exercise in low and moderate altitude
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Recurrent Adult Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Anti-CD33 CAR T-cells|PROCEDURE: Lymphodepletion Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electronic Tools to Increase Recognition and Improve Primary Care Management for Hypertension in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Hypertension
Interventions: OTHER: Intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess Cap-Assisted Colonoscopy Versus Regular Colonoscopy for the First or Repeated Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy|Lower Gastrointestinal Tract
Interventions: PROCEDURE: Cap-assisted colonoscopy|PROCEDURE: Cap-assisted colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Tailored Interactive Multimedia to Reduce Colorectal Cancer Screening Disparities
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: BEHAVIORAL: Personally tailored computer program|BEHAVIORAL: Non-tailored control computer program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Effect of a Resistance Training Program in Healthcare Workers on Pain, Workability and Physical Function.
Status: COMPLETED
Conditions: Musculoskeletal Pain|Physical Function|Work Ability
Interventions: OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Tiragolumab Plus Atezolizumab and Atezolizumab Monotherapy in Participants With Metastatic and/or Recurrent PD-L1-Positive Cervical Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Tiragolumab|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Ingenol Mebutate Compared to 5-FU to Treat Facial Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: ingenol mebutate|DRUG: 5% 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate and Interferon Alfa in Treating Patients With Chronic Myelogenous Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: BIOLOGICAL: recombinant interferon alfa|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry
Status: ENROLLING_BY_INVITATION
Conditions: Ventricular Arrhythmia|Ventricular Tachycardia|Premature Ventricular Contraction (PVC)|Cardiomyopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate if Response to Infliximab or Adalimumab May be Regained With an Immunomodulator
Status: TERMINATED
Conditions: Inflammatory Bowel Disease|Ulcerative Colitis|Crohn's Disease
Interventions: DRUG: Azathioprine|DRUG: 6 mercaptopurine|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Keeping it Simple Study (KISS)
Status: RECRUITING
Conditions: Musculoskeletal Pain|Chronic Pain
Interventions: OTHER: PNE4Adults - pain science education|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma
Status: COMPLETED
Conditions: Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System
Interventions: DRUG: carmustine|RADIATION: radiation therapy|DRUG: O6-Benzylguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Versus High Dialysate Sodium Concentration During Hemodialysis on Dialysis Recovery Time
Status: RECRUITING
Conditions: Dialysis; Complications
Interventions: OTHER: high dialysate Na|OTHER: low dialysate Na
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality
Status: COMPLETED
Conditions: Suicidal Ideation
Interventions: DRUG: Estradiol Transdermal Patch 0.1 mg/24 hrs|DRUG: Oral Micronized Progesterone|DRUG: Inactive Clear Patch|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Emotion Regulation and Burnout Impact on Communication Documentation
Status: WITHDRAWN
Conditions: Communication
Interventions: BEHAVIORAL: Communication Skills Training|BEHAVIORAL: Profile feedback|OTHER: Maslach burnout inventory|OTHER: Emotion Regulation Skills Question (ERSQ)|OTHER: Semi-structured interview|BEHAVIORAL: Priming
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Validate the Effects of an Outpatient Secondary Prevention Program for Stroke Victims
Status: COMPLETED
Conditions: Cerebrovascular Disorders|Stroke|Prevention
Interventions: BEHAVIORAL: Outpatient secondary prevention program|BEHAVIORAL: Standard treatment by family physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilates Exercise Versus Manual Lymphatic Drainage On Axillary Web Syndrome Post Mastectomy
Status: COMPLETED
Conditions: Mastectomy; Lymphedema
Interventions: OTHER: Pilates exercise|OTHER: Manual lymphatic massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Oxcarbazepine Oral Suspension 300 mg/5mL Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: oxcarbazepine 300 mg/5 mL oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: 1X level of MSCs-Exo|BIOLOGICAL: 2X level of MSCs-Exo|BIOLOGICAL: 4X level of MSCs-Exo|BIOLOGICAL: 6X level of MSCs-Exo|BIOLOGICAL: 8X level of MSCs-Exo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thymalfasin-based PRaG Mode for Advanced Refractory Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Refractory Tumor
Interventions: DRUG: Thymalfasin|RADIATION: Radiotherapy|DRUG: PD-1/PD-L1 inhibitor|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Oral MP1032 in Psoriasis Patients
Status: COMPLETED
Conditions: Psoriasis|Plaque Psoriasis
Interventions: DRUG: MP1032|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Alisertib (MLN8237) in Combination With Paclitaxel Versus Placebo in Combination With Paclitaxel as Second Line Therapy for Small Cell Lung Cancer (SCLC)
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: Alisertib|DRUG: Placebo|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Real-world Study to Explore the Effects of Fortified Powdered Beverage on Sleep Quality in Chinese Adults With Mild Sleep Issue(s) or Complaint(s)
Status: RECRUITING
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: Fortified Powdered Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Erlotinib, Gemcitabine, and Radiation Therapy in Treating Patients With Locally Advanced Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Recurrent Pancreatic Cancer|Stage II Pancreatic Cancer|Stage III Pancreatic Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compound Sodium Alginate Oral Suspension Sachet 4-hour Esophageal pH Study in GERD Patients
Status: TERMINATED
Conditions: Gastro-esophageal Reflux Disease (GERD)
Interventions: DRUG: Compound Sodium Alginate Oral Suspension sachet|DRUG: Matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam
Status: COMPLETED
Conditions: Analgesia, Patient-controlled|Spinal Stenosis
Interventions: DRUG: s-ketamine & midazolam|DRUG: Morphine PCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of BIS Monitoring in Deep Hypnotic State
Status: NOT_YET_RECRUITING
Conditions: Hypnotic; Withdrawal State With Delirium|Neurological Disorder|Postoperative Delirium|Postoperative Confusion|Anesthesia|Anesthesia Emergence Delirium|Gas; Inhalation
Interventions: DEVICE: BIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Using Beta Blockers to Treat Mitral Regurgitation
Status: TERMINATED
Conditions: Heart Disease|Mitral Regurgitation|Heart Valve Disease|Mitral Valve Insufficiency
Interventions: DRUG: Beta-blocker therapy (TOPROL-XL® )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults
Status: COMPLETED
Conditions: Smallpox|Poxvirus Infection
Interventions: BIOLOGICAL: Smallpox vaccine, LISTER strain, from chick embryo cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigating Microparticle Levels In Filtered Packed Red Blood Cell Units
Status: RECRUITING
Conditions: Packed Red Cells Causing Adverse Effects in Therapeutic Use
Interventions: DIAGNOSTIC_TEST: b. Detection of micro particles and their subtypes by flow cytometery on(BECKMAN COULTER CytoFLEX flow cytometer).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Redefining BMI: The Body, Mind, and Inflammation Trial
Status: NOT_YET_RECRUITING
Conditions: Obesity|Adiposity
Interventions: BEHAVIORAL: Integrated Lifestyle Intervention (ILI)|BEHAVIORAL: Monitoring with digital tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Bortezomib and Panobinostat in Treating Patients With Relapsed/Refractory Peripheral T-cell Lymphoma or NK/T-cell Lymphoma
Status: COMPLETED
Conditions: Peripheral T-cell Lymphoma (Not Otherwise Specified)|Angioimmunoblastic T-cell Lymphoma|Extranodal NK/T-cell Lymphoma Nasal Type|Enteropathy- Type T-cell Lymphoma|Hepatosplenic T-cell Lymphoma|Anaplastic Large Cell Lymphoma (ALCL) (ALK-1 Negative)|Relapsed ALCL (ALK-1 Positive) Post Autologous Transplant
Interventions: DRUG: panobinostat and bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Open-Label Single-Arm Multi-Cohort Phase I Study of BCD-100 in Patients With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Melanoma|Lung Cancer|Renal Cell Carcinoma
Interventions: BIOLOGICAL: BCD-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-acetyl Cysteine Effect in Peripheral Neuropathy in Cancer Patients
Status: COMPLETED
Conditions: Peripheral Neuropathy Due to Chemotherapy
Interventions: DIETARY_SUPPLEMENT: low dose N-acetylcysteine|DIETARY_SUPPLEMENT: high dose N-acetylcysteine|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Addition of Fluticasone Propionate/Salmeterol (250/50mcg) Twice-daily to 2 Doses of Umeclidinium Bromide Inhalation Powder (62.5 or 125mcg) Once-daily Over 12 Weeks.
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Umeclidinium bromide 62.5mcg|DRUG: Umeclidinium bromide 125mcg|DRUG: Fluticasone propionate 250mcg/Salmeterol 50mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Single-Dose Oral CEM-101 in Patients With Uncomplicated Urogenital Gonorrhea
Status: COMPLETED
Conditions: Uncomplicated Urogenital Gonorrhea
Interventions: DRUG: solithromycin|DRUG: Solithromycin (CEM-101)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Cancer Therapy for Patients With Metastatic Medullary Thyroid or Metastatic Colon Cancer
Status: TERMINATED
Conditions: Medullary Thyroid Cancer|Colon Cancer
Interventions: OTHER: Tumor Genomic Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Multimedia Education for Patients With Type 2 Diabe Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Insulin|Education
Interventions: BEHAVIORAL: multimedia health education|BEHAVIORAL: regular health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Adaptive Open-label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of CCTx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients With Relapsed/Refractory Acute Myeloid Leukaemia
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia, in Relapse|Acute Myeloid Leukemia Refractory
Interventions: GENETIC: CCTx-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Metformin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Placebo-controlled Study of Levetiracetam in Epilepsy Patients With Generalized Tonic-clonic Seizures (Except Partial Seizures Evolving to Secondarily Generalized Seizures)
Status: COMPLETED
Conditions: Epilepsy|Generalized Tonic-Clonic Seizures
Interventions: DRUG: Levetiracetam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tiotropium Bromide in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: tiotropium Respimat® inhaler|DRUG: Placebo Respimat® inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study Of Intraductal Carboplatin In Women With Ductal Carcinoma In Situ (DCIS)
Status: UNKNOWN
Conditions: Ductal Carcinoma In Situ
Interventions: DRUG: Carboplatin i.d. Days 1 & 15|DRUG: Carboplatin i.d. Day 1; Normal Saline i.d. Day 15|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy, Chemoradiotherapy and Surgery in Locally Advanced Gastric Cancer Patients
Status: COMPLETED
Conditions: Gastric Cancer|Adenocarcinoma|Effects of Chemotherapy|Surgery|Gastrointestinal Neoplasms
Interventions: DRUG: Induction chemotherapy|RADIATION: Radiotherapy with concurrent chemotherapy|PROCEDURE: Salvage surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma, Burkitt's
Interventions: DRUG: Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation (tDCS) in the Primary Motor Cortex in Healthy Individuals
Status: COMPLETED
Conditions: Basic Physiology|Brain Stimulation
Interventions: DEVICE: Sooma transcranial direct current stimulation device|DEVICE: Placebo Sooma transcranial direct current stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topical Formulations of Liposomal Local Anesthetics
Status: COMPLETED
Conditions: Administration, Topical Drug|Administration, Topical|Anesthetic Drugs
Interventions: DRUG: Ropivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Liver Resection and Simultaneous Sleeve Gastrectomy for MS-HCC (LIRESS)
Status: NOT_YET_RECRUITING
Conditions: Carcinoma, Hepatocellular|Metabolic Syndrome
Interventions: PROCEDURE: Liver resection and simultaneous sleeve gastrectomy for HCC induced by metabolic syndrome|PROCEDURE: Liver resection for HCC induced by metabolic syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fit Families Program: Fundamental Motor Skill Intervention in Children With Autism Spectrum Disorders and Their Parents
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: OTHER: 12-week FMS Intervention|BEHAVIORAL: Physical Activities & Activity Booklets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reliability and Physiological Analysis of an Isometric Test of Localized Muscular Fatigue
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIAGNOSTIC_TEST: Reliability of IET|DIAGNOSTIC_TEST: Physiological analysis of IET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pilot Study of Swift Microwave Device for Onychomycosis
Status: RECRUITING
Conditions: Onychomycosis of Toenail
Interventions: DEVICE: Swift Microwave treatment - weekly x 4wks|DEVICE: Swift Microwave treatment - Every other week x 4wks|DEVICE: Swift Microwave treatment - Every other week x 24wks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine To Prevent Hypotension After Spinal Anesthesia For Cesarean Delivery: A Dose Finding Study
Status: COMPLETED
Conditions: Hypotension
Interventions: DRUG: Norepinephrine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting|Cardiopulmonary Bypass
Interventions: DRUG: Nicardipine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis
Status: TERMINATED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: Cilofexor|DRUG: Placebo to match cilofexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid-Free Pain Protocol After Shoulder Arthroplasty
Status: RECRUITING
Conditions: Shoulder Arthropathy|Shoulder Pain
Interventions: DRUG: Celecoxib|DRUG: Pregabalin|DRUG: Tramadol|DRUG: Dexamethasone|DRUG: Acetaminophen|DRUG: Ropivicaine|DRUG: Epinephrine|DRUG: Ketorolac|DRUG: Tizanidine|DRUG: Magnesium|DRUG: Ibuprofen|DRUG: Oxycodone Hydrochloride 5 Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate SAGE-547 in Participants With Severe Postpartum Depression
Status: COMPLETED
Conditions: Severe Postpartum Depression
Interventions: DRUG: SAGE-547|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response
Status: COMPLETED
Conditions: Muscle Protein Synthesis
Interventions: DIETARY_SUPPLEMENT: Bolus ingestion of protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nitric Oxide Footbath for Treatment of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: Nitric Oxide-Releasing Solution|DRUG: Saline solution, hypotonic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Versus Bupivacaine for Sphenopalatine Ganglion Block
Status: COMPLETED
Conditions: Septum; Deviation, Congenital
Interventions: PROCEDURE: Sphenopalatine Ganglion Block (SPGB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thrombectomy Under Reopro Versus Alteplase to Treat Stoke
Status: TERMINATED
Conditions: Infarction, Middle Cerebral Artery
Interventions: PROCEDURE: abciximab IV and thrombectomy|DRUG: alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Elimination Procedure of Teriflunomide With Colestipol Hydrochloride
Status: TERMINATED
Conditions: Teriflunomide Elimination|Healthy Volunteers
Interventions: DRUG: teriflunomide|DRUG: Colestipol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Long-term Follow-up Study of Botulinum Toxin Type A in Patients With Overactive Bladder as a Result of Spinal Injury or Multiple Sclerosis
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: Botulinum Toxin Type A 300U|BIOLOGICAL: Botulinum Toxin Type A 200U
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelial Function in Patients With Type 2 Diabetes Versus Healthy Subjects
Status: COMPLETED
Conditions: Insulin Resistance|Type 2 Diabetes
Interventions: OTHER: mixed meal|OTHER: Acute in vivo induced hyperinsulinemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Frailty and Physician Modified Fenestrated Endograft for Thoracoabdominal Aortic Pathologies
Status: RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysm|Thoracoabdominal; Aortic, Aneurysm, Dissecting|Pararenal Aneurysm|Frailty Syndrome
Interventions: DEVICE: Physician Modified Endografts
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hetrombopag for Lower-risk MDS With Thrombocytopenia: a Prospective，Open-label, Single-arm Study.
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Hetrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections
Status: TERMINATED
Conditions: Soft Tissue Infections
Interventions: DRUG: daptomycin (up to 14 days)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melphalan, Bortezomib, and Stem Cell Transplant in Treating Patients With Primary Systemic Amyloidosis
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: filgrastim|DRUG: bortezomib|DRUG: melphalan|PROCEDURE: Stem Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT