pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET photon therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pain Management in Corneal Collagen Crosslinking for Keratoconus
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Gabapentin|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapy
Status: TERMINATED
Conditions: Leukaemia, Lymphocytic, Chronic
Interventions: BIOLOGICAL: Ofatumumab|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor Ablation With Talaporfin Sodium and Interstitial Light Emitting Diodes Treating Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Liver Neoplasms
Interventions: PROCEDURE: Photodynamic therapy|DRUG: Talaporfin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plan Development for Giving Teclistamab in the Outpatient Setting
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Relapsed Cancer|Refractory Cancer
Interventions: DRUG: Teclistamab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of the Resection Rate of Cold Snare Polypectomy for Large (10-15 mm) and Small (5-9 mm) Colorectal Polyps
Status: COMPLETED
Conditions: Adenomatous Polyps
Interventions: OTHER: Cold snare polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tau And Connectomics In TES Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Traumatic Encephalopathy|Traumatic Encephalopathy|Head Injury Trauma|Cognitive Impairment|Neurodegenerative Diseases
Interventions: RADIATION: [18F] PI-2620 Tau Ligand
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Anti-inflammatory Diet Effect on Metabolic, Inflammatory and Immune Status of Obese Younger Adults
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Anti-inflammatory energy-restricted diet|BEHAVIORAL: Control energy-restricted diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Hormone Exposure From Multiple Commercial Lots of ORTHO EVRA (a Transdermal Contraceptive Patch)
Status: COMPLETED
Conditions: Contraception|Female Contraception
Interventions: DRUG: EVRA transdermal contraceptive patch 6 mg NGMN and 0.75 mg EE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Effects of Fermented and Unfermented Pulses and Gut Microbiota
Status: NOT_YET_RECRUITING
Conditions: Fermented Food|Inflammation
Interventions: OTHER: Unfermented chickpea|OTHER: Fermented chickpea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Trauma Informed Care in Childbirth
Status: COMPLETED
Conditions: Psychological Well-being|Childbirth|Care Pattern, Maternal
Interventions: OTHER: Experimental: Supportive Care based on trauma informed care|OTHER: Standart care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Treatment With Subcutaneous Immunoglobulin (IgPro20)
Status: COMPLETED
Conditions: Chronic Inflammatory Demyelinating Polyneuropathy|Polyradiculoneuropathy
Interventions: BIOLOGICAL: IgPro20 (low dose)|BIOLOGICAL: Placebo|BIOLOGICAL: IgPro10|BIOLOGICAL: IgPro20 (high dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Dexmeditomidine for Prevention of Spinal Anesthesia Induced Shivering.
Status: UNKNOWN
Conditions: Postoperative Shivering|Cesarean Delivery
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Ataxia and Exercise Disease Using MRI and Gait Analysis
Status: COMPLETED
Conditions: Ataxia|Spino Cerebellar Degeneration|Spinocerebellar Ataxias
Interventions: BEHAVIORAL: Aerobic Training|BEHAVIORAL: Balance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biologic Mesh Versus Synthetic Mesh in Repair of Ventral Hernias
Status: COMPLETED
Conditions: Ventral Hernia
Interventions: DEVICE: Davol Bard Soft Mesh synthetic|DEVICE: LifeCell Strattice Reconstructive Tissue Biologic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gluten Immunity and Islet Autoimmunity in Type-1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes|Celiac Disease
Interventions: DIETARY_SUPPLEMENT: Gluten Challenge|DIETARY_SUPPLEMENT: Sham Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Choline Fenofibrate (SLV348) on Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Choline Fenofibrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous T-Cells Combined With Autologous OC-DC Vaccine in Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Carcinoma|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: BIOLOGICAL: OC-DC vaccine|DRUG: Bevacizumab|DRUG: cyclophosphamide 300 mg/m2/d for 3 days|DRUG: fludarabine 30 mg/m2/d for 3 days|DRUG: ex vivo CD3/CD28-costimulated vaccine-primed peripheral blood autologous T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Modification Programme for Patients With Peripheral Arterial Disease
Status: UNKNOWN
Conditions: Peripheral Arterial Occlusive Disease
Interventions: BEHAVIORAL: Risk Factors Modification Programme|BEHAVIORAL: Standard Healthcare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arbaclofen vs. Placebo in the Treatment of Children and Adolescents With ASD (ARBA)
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Arbaclofen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Sibling Oocytes: ICSI vs. the IMSI Sperm Selection Method
Status: UNKNOWN
Conditions: Infertility
Interventions: OTHER: Standard ICSI procedure for sperm injection into oocyte|DEVICE: MSOME|OTHER: IMSI Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bronchodilating and Bronchoprotective Effects of Deep Inspirations
Status: COMPLETED
Conditions: Asthma|Cough
Interventions: OTHER: Methacholine(MCh) Challenge Testing|OTHER: Methacholine(MCh) Challenge Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery
Status: TERMINATED
Conditions: Heart Diseases|Hypertension, Pulmonary
Interventions: DRUG: tezosentan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Transtheoretical Model Group Therapy for Cocaine
Status: COMPLETED
Conditions: Cocaine Use Disorders
Interventions: BEHAVIORAL: Transtheoretical Model Group Therapy|BEHAVIORAL: Education & Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Patient-Centered Strategy for Improving Diabetes Prevention in Urban American Indians
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Metabolic Syndrome|Insulin Resistance
Interventions: BEHAVIORAL: Standard DPP|BEHAVIORAL: Enhanced DPP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail
Status: UNKNOWN
Conditions: Intertrochanteric Fracture
Interventions: DEVICE: new type of intramedullary nail|DEVICE: The intramedullary nail of PFNA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bright Light Therapy in Seasonal Affective Disorder (SAD)
Status: UNKNOWN
Conditions: Seasonal Affective Disorder
Interventions: OTHER: Bright light therapy|OTHER: Inactive "placebo-light"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LFMS: Initial Trial in Geriatric Bipolar Depression
Status: TERMINATED
Conditions: Bipolar Depression Depressed Phase
Interventions: DEVICE: Active Low Field Magnetic Stimulation|DEVICE: Sham Low Field Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: BNC210|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in the Risk Factors of Coronary Heart Disease Observed After Scaling and Root Planing
Status: COMPLETED
Conditions: Coronary Heart Disease|Periodontitis
Interventions: DEVICE: piezoelectric ultrasonic scaler (frequency of 28-36 KHz)|DEVICE: Gracey curettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Camrelizumab for Injection in Combination With Famitinib Malate Capsule and Paclitaxel For Injection(Albumin Bound) in Advanced Solid Tumors of Patients
Status: ENROLLING_BY_INVITATION
Conditions: Advanced Solid Tumors
Interventions: DRUG: Camrelizumab for Injection, Famitinib malate capsule, Paclitaxel For Injection(Albumin Bound)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kybella With Triamcinolone
Status: COMPLETED
Conditions: Adiposity
Interventions: DRUG: Injectable sodium deoxycholate|COMBINATION_PRODUCT: Injectable sodium deoxycholate with Triamcinolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Rituximab Combined With Omalizumab in Patients With Bullous Pemphigoid
Status: WITHDRAWN
Conditions: Bullous Pemphigoid
Interventions: DRUG: Rituximab combined with Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Shivering Associated With Spinal Anesthesia
Status: NOT_YET_RECRUITING
Conditions: Shivering, Spinal Anesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine|DRUG: Meperidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Antibiotic Prescribing for Pediatric Respiratory Infections by Family Physicians With Peer Comparison
Status: COMPLETED
Conditions: Upper Respiratory Infection|Acute Bacterial Sinusitis|Acute Otitis Media
Interventions: BEHAVIORAL: Peer comparison feedback monthly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: GOS and Insulin Sensitivity
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Galactooligosaccharide|DIETARY_SUPPLEMENT: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of FLEXISEQ® for Treatment of Osteoarthritis of the Knee in NSAID-compromised Patients
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DEVICE: FLEXISEQ®|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Arch Watch Study: An Integrated Evaluation of Hemodynamics in Infants With Suspected Coarctation of the Aorta
Status: ENROLLING_BY_INVITATION
Conditions: Coarctation of the Aorta|Aortic Arch Obstruction
Interventions: DEVICE: Monitoring using resonance Raman spectroscopy, pulse oximetry, blood pressure, and near-infrared spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rescue Immunotolerance Study in Induction of Immune Tolerance (ITI)-Experienced Patients (RES.I.S.T. Experienced)
Status: COMPLETED
Conditions: Severe Hemophilia A
Interventions: DRUG: VWF/FVIII concentrates
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Enhanced Recovery After Surgery (ERAS) Pathways In Major Gynecologic Oncology Operations In Greece
Status: UNKNOWN
Conditions: Ovarian Cancer|Hysterectomy|Endometrial Cancer|Gynecologic Cancer
Interventions: OTHER: ERAS protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Non-surgical Mechanical Debridement With or Without Full-mouth Disinfection in the Treatment of Peri-implant Mucositis
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: OTHER: Placebo mouthwash|OTHER: Full mouth disinfection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Japan Diabetes Optimal Integrated Treatment Study for 3 Major Risk Factors of Cardiovascular Diseases
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Lifestyle consultation: weight control, diet, exercise|BEHAVIORAL: Lifestyle consultation: weight control, diet, exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of QGE031 (Ligelizumab) in Patients With Peanut Allergy
Status: TERMINATED
Conditions: Allergy, Peanut
Interventions: DRUG: ligelizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digestive and Nutritional Effects of Probiotics Supplementation in Premature Newborns
Status: COMPLETED
Conditions: Duration of Parenteral Nutrition
Interventions: DIETARY_SUPPLEMENT: Probiotics supplementation until weight reaches 1800g (Bifidobacterium Longum and Lactobacillus GG )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Collection of Samples From Subjects With Various Skin Conditions and Healthy Volunteers
Status: RECRUITING
Conditions: Acne|Atopic Dermatitis|Chronic Hand Eczema|Hidradenitis Suppurativa|Plaque Psoriasis|Palmoplantar Pustulosis
Interventions: PROCEDURE: Blood samples collection|PROCEDURE: Oral samples collection|PROCEDURE: Hair samples collection|PROCEDURE: Skin samples collection (skin tape strip and/or skin biopsy, and/or skin scraping)|PROCEDURE: Skin surface material samples|PROCEDURE: Drainage fluid samples collection|PROCEDURE: Stool samples collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Surgeon Perception of Gastric Decompression at Time of Gynecologic Laparoscopy
Status: RECRUITING
Conditions: Gynecologic Surgical Procedures|Gastric Injury|Aspiration|Nausea, Postoperative|Postoperative Complications|Enhanced Recovery After Surgery|Laparoscopy
Interventions: PROCEDURE: Gastric decompression (oropharyngeal or nasopharyngeal gastric tube)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Artificial Tears Study in Mild to Moderate Dry Eye Patients
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: (9587X) Blink Tears, classified as an OTC Drug with the active ingredient being plyethylene glycol 400|DRUG: Systane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Evaluating The Safety And Response To Neoadjuvant Dasatinib In Early Stage Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study of Panobinostat (LBH589) in Combination With 5-Azacitidine for Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML) or Acute Myeloid Leukemia (AML) Patients
Status: COMPLETED
Conditions: Myelodysplastic Syndromes (MDS)|Chronic Myelomonocytic Leukemia (CMML)|Acute Myeloid Leukemia (AML)
Interventions: DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Activity of Metformin With High-dose of Dexamethasone in Relapse Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Metformin XR|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic
Status: COMPLETED
Conditions: Pain, Postoperative|Morbid Obesity
Interventions: DRUG: Injected bupivacaine post-operatively|DRUG: Streamed bupivacaine versus streamed normal saline|DRUG: Aerosolized bupivacaine versus aerosolized saline|DRUG: Injected lidocaine pre-incision vs saline pre-incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Proton Pump Inhibitors in Gastrointestinal Erosions and/or Ulcers
Status: RECRUITING
Conditions: Gastrointestinal Erosions and/or Ulcers
Interventions: DRUG: Oral Bonoprazan|DRUG: Oral Esomeprazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Facebook as a Motivating Factor in a Weight-reduction Program for Obese and Overweight Adolescents
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: OTHER: Facebook Status Update
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Traxi Panniculus Retractor for Cesarean Delivery
Status: RECRUITING
Conditions: Obesity, Morbid|Cesarean Section Complications
Interventions: DEVICE: Traxi panniculus retraction (Clinical Innovations, LLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: San Rocco Study: Implementation of the Non-pharmacological Therapies for People With Dementia Living in Nursing Home
Status: COMPLETED
Conditions: Nursing Home|Dementia|Staff
Interventions: BEHAVIORAL: Training on non-pharmacological therapies' methodology
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of Void With Saline Bladder Instillation
Status: COMPLETED
Conditions: Urethral Catheter Removal After Urologic Procedure
Interventions: PROCEDURE: Room temperature saline instillation|PROCEDURE: Warmed saline instillation|PROCEDURE: No saline instillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Andrographis Paniculata Purified Standardized Extract (ApE) in Patients With Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: 1 - Andrographis paniculata p/st extract|DRUG: 2 - Excipients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Pharmacokinetics of BI 655066/ABBV-066 (Risankizumab) in Patients With Active, Moderate-to-severe Crohn's Disease.
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: risankizumab IV|DRUG: risankizumab SC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Compare Efficacy and Safety of Follitropin Delta Versus Placebo (Inactive Treatment) in the Treatment of Men With Idiopathic Infertility (Unexplained Reduction of Semen Quality) (ADAM)
Status: RECRUITING
Conditions: Male Idiopathic Infertility
Interventions: DRUG: FE 999049|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Mitomycin C, Amniotic Membrane Transplantation and Conjunctival Autograft for Primary Pterygium
Status: UNKNOWN
Conditions: Pterygium
Interventions: PROCEDURE: MMC|PROCEDURE: AMT|PROCEDURE: CAG|PROCEDURE: Pterygium excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Orally Administered JBPOS0101 in Refractory Infantile Spasms Patients
Status: TERMINATED
Conditions: Refractory Infantile Spasms
Interventions: DRUG: JBPOS0101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Topical Danazol for the Treatment of Pain Associated With Fibrocystic Breast Disease
Status: COMPLETED
Conditions: Fibrocystic Disease of Breast
Interventions: DRUG: danazol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Reinfusion of Tisagenlecleucel in Pediatric and Young Adult Patients With Acute Lymphoblastic Leukemia (ALL)
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Tisagenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of GLA (5 mcg) on Human Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: GLA-AF|BIOLOGICAL: GLA-SE|BIOLOGICAL: EM060G (SE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Empirical Antifungal Treatment in ICUS
Status: COMPLETED
Conditions: Invasive Candidiasis
Interventions: DRUG: Micafungin|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages
Status: COMPLETED
Conditions: Vitamin D Insufficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: EXCEL Clinical Trial
Status: COMPLETED
Conditions: Chronic Coronary Occlusion|Unprotected Left Main Coronary Artery Disease|Stent Thrombosis|Vascular Disease|Myocardial Ischemia|Coronary Artery Stenosis|Coronary Disease|Coronary Artery Disease|Coronary Restenosis
Interventions: DEVICE: Percutaneous Coronary Intervention|PROCEDURE: CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Efficacy and Safety of VTAMA® (Tapinarof) Cream, 1% in Plaque Psoriasis in the Head and Neck Region
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: VTAMA (tapinarof) cream, 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Experience From the Italian S-ICD Registry
Status: UNKNOWN
Conditions: Sudden Cardiac Death|Cardiac Arrest|Ventricular Arrythmia|Implantable Cardiac Defibrillator
Interventions: DEVICE: Subcutaneous Implantable Cardioverter Defibrillator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Hematopoietic Stem Cell Transplantation Combined With CAR-T Cells in the Treatment of Refractory and Relapsed Malignant Lymphoma
Status: RECRUITING
Conditions: Lymphoma
Interventions: BIOLOGICAL: Autologous hematopoietic stem cell transplantation combined with CD19 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Towards Comparative Effectiveness in Military Vestibular Rehabilitation
Status: UNKNOWN
Conditions: Vestibular Problem|Traumatic Brain Injury
Interventions: OTHER: Generalized Vestibular Rehabilitation Treatment|OTHER: Individualized Vestibular Rehabilitation Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind-randomized,Placebo Controlled Trial for Chemotherapy-associated Oral Mucositis Using Doxycycline Hyclate
Status: UNKNOWN
Conditions: Mucositis
Interventions: DRUG: Doxycycline hyclate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Ulevostinag (MK-1454) Alone or in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors or Lymphomas (MK-1454-001)
Status: COMPLETED
Conditions: Solid Tumors|Lymphoma
Interventions: DRUG: Ulevostinag|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lidocaine 1% and 2% in the Tube Cuff on Postoperative Sore Throat and Cough
Status: UNKNOWN
Conditions: Postoperative Sore Throat|Postoperative Cough
Interventions: OTHER: cuff inflation with air|DRUG: cuff inflation with lidocaine 1%|DRUG: cuff inflation with lidocaine 2%|OTHER: Induction of anesthesia|OTHER: Maintenance of anesthesia|OTHER: Endotracheal intubation|OTHER: Systematic post-operative analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of QLS1128 and in Combination With Ritonavir in Healthy Participants
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: QLS1128 A-Dose 1~5 and Ritonavir|DRUG: QLS1128 C-Dose 1~3 and Ritonavir|DRUG: QLS1128 D-Dose 1 and Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAPOX + Bevacizumab + Tirelizumab Treating PDL1 CPS < 5 GEA
Status: RECRUITING
Conditions: Advanced Gastroesophageal Adenocarcinoma|First-line Therapy|PDL1 CPS < 5
Interventions: DRUG: CAPOX combined with bevacizumab and Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Clinical Trial of ST-02 for Ablation of Upper Tract Urothelial Carcinoma
Status: RECRUITING
Conditions: Urothelial Carcinoma of the Renal Pelvis and Ureter|Transitional Cell Cancer of the Renal Pelvis and Ureter
Interventions: DRUG: ST-02
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK of Clindamycin and Trimethoprim-sulfamethoxazole in Infants and Children
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: Clindamycin|DRUG: trimethoprim-sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Microbiome Use to Stratify Use of Inhaled Corticosteroids: MUSIC Trial
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Budesonide & formoterol fumarate and Aclidinium bromide|DRUG: Fluticasone 500 & salmeterol and Aclidinium bromide|DRUG: Fluticasone 250 & salmeterol and Aclidinium bromide|DRUG: Aclidinium bromide & formoterol fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused by Thyroidectomy in Thyroid Cancer Patients.
Status: UNKNOWN
Conditions: Thyroid Cancer, Papillary|Hypothyroidism
Interventions: DRUG: L-T4|DRUG: L-T4+T3 (thyroid tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: DRUG: REGN475|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Quadrivalent High-Dose Influenza Vaccine and a Moderna COVID-19 Vaccine Administered Either Concomitantly or Singly in Participants 65 Years of Age and Older Previously Vaccinated With a 2-dose Schedule of Moderna COVID-19 Vaccine
Status: COMPLETED
Conditions: Influenza Immunization|Healthy Volunteers
Interventions: BIOLOGICAL: Quadrivalent Inactivated Influenza High Dose|BIOLOGICAL: COVID-19 mRNA Vaccine (nucleoside modified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Carcinoma
Interventions: BIOLOGICAL: Botulinum Toxin Type A|PROCEDURE: Esophagectomy|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Modified Constraint-Induced Aphasia Therapy Schedule to Treat Patients Following Sub-acute Stroke
Status: COMPLETED
Conditions: Aphasia
Interventions: OTHER: Investigate efficacy of modified ciat schedule|OTHER: examine the efficacy of standard treatment versus modified ciat schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SOM3355 in Huntington's Disease Chorea
Status: COMPLETED
Conditions: Huntington's Chorea
Interventions: DRUG: SOM3355 100mg BID|DRUG: SOM3355 200mg BID|DRUG: Placebo BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Fermented Soy Product on Cognition, Immune Status and Vaccine
Status: COMPLETED
Conditions: Cognitive Change|Inflammation|Immune Response
Interventions: DIETARY_SUPPLEMENT: Q CAN PLUS|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)
Status: RECRUITING
Conditions: Urinary Incontinence in Children
Interventions: DRUG: Solifenacin|DRUG: Mirabegron|DRUG: Solifenacin + Mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Grade Adenovirus Specific T Cells for Immunotherapy After Allogeneic Stem Cell Transplantation (CTL-ADV)
Status: COMPLETED
Conditions: Adenovirus Infection
Interventions: OTHER: Infusion of ADV specific T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIA Assessment of Polymyoneuropathy in Critically Ill Patients
Status: RECRUITING
Conditions: Sepsis|Trauma|Respiratory Insufficiency|Surgery
Interventions: OTHER: Nutritional and physiotherapy protocol, BIA|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Benralizumab Treatment on Circulating Dendritic Cells in Patients With Eosinophilic Asthma
Status: UNKNOWN
Conditions: Severe Eosinophilic Asthma
Interventions: DRUG: Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cysteine Supplementation in Critically Ill Neonates
Status: UNKNOWN
Conditions: Sepsis|Bronchopulmonary Dysplasia|Necrotizing Enterocolitis|Retinopathy of Prematurity|Systemic Inflammatory Response Syndrome
Interventions: DIETARY_SUPPLEMENT: Parenteral cysteine-HCl supplementation|DIETARY_SUPPLEMENT: Placebo - added premasol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab and Irinotecan in Treating Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Alectnib|DRUG: Cisplatin|DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics and Pharmacodynamics Between HR011408 and NovoRapid® in Healthy Subject
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: HR011408 injection; NovoRapid®|DRUG: NovoRapid®；HR011408 injection|DRUG: HR011408 injection; NovoRapid®|DRUG: NovoRapid®；HR011408 injection|DRUG: HR011408 injection; NovoRapid®|DRUG: HR011408 injection; NovoRapid®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1B Study of KSP/QRH Dimer for Detection of Neoplasia in the Esophagus
Status: TERMINATED
Conditions: Barrett Esophagus
Interventions: DRUG: KSP/QRH dimer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Trial of Subcutaneous Immunotherapy in Mite Induced Asthma
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: BIOLOGICAL: Pangramin Plus D. pteronyssinus 100%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of LCZ696 and Valsartan in Asian Patients With Salt-sensitive Hypertension
Status: COMPLETED
Conditions: Salt-sensitive Hypertension
Interventions: DRUG: Valsartan|DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Adsorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled SPD557 in Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Radiolabeled SPD557
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Study of LY2787106 in Cancer and Anemia
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: LY2787106|DIETARY_SUPPLEMENT: Iron Supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Test Different Doses of BI 730357 and Find Out Whether They Reduce Symptoms in People With Active Psoriatic Arthritis
Status: WITHDRAWN
Conditions: Arthritis, Psoriatic
Interventions: DRUG: BI 730357|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Nutrition for Adult Recipients of Allogeneic Stem Cell Transplants - Effect on Quality of Life
Status: COMPLETED
Conditions: Effect of Individualized Nutrition on Quality of Life
Interventions: DIETARY_SUPPLEMENT: Individualized Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Investigational Study to Evaluate Experimental Medication BMS-986036 in Participants With Different Levels of Kidney Function
Status: COMPLETED
Conditions: NAFLD|Nonalcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis
Interventions: DRUG: BMS-986036
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restenosis Following Paclitaxel Eluting Balloon Angioplasty of Hemodialysis Access Stenosis
Status: COMPLETED
Conditions: Renal Failure
Interventions: DEVICE: Percutaneous Transluminal Angioplasty (PTA)|DEVICE: Paclitaxel Eluting Balloon Angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of the Solysafe Septal Occluder in Patients With Atrial Septum Defect and Patent Foramen Ovale
Status: COMPLETED
Conditions: Atrial Septal Defect|Patent Foramen Ovale
Interventions: DEVICE: Solysafe Septal Occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of the Drug Ster® Compared With Predfort® in Control of Postoperative Inflammation in Cataract Surgery
Status: COMPLETED
Conditions: Inflammation|Cataract Surgery
Interventions: DRUG: Ster|DRUG: Pred Fort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of IV Peramivir in Addition to Standard of Care Compared to Standard of Care Alone in Adults and Adolescents Who Are Hospitalized Due to Influenza
Status: TERMINATED
Conditions: Cough|Sore Throat|Nasal Congestion|Headache|Fever|Seasonal Influenza
Interventions: DRUG: Peramivir+SOC|DRUG: Placebo+SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Epilepsy, Temporal Lobe
Interventions: DEVICE: Central Thalamic Stimulation|DEVICE: Hippocampal Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Anti-PD1 Epigenetic Therapy Study in NSCLC.
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Epigenetic Therapy
Interventions: DRUG: Azacitidine|DRUG: Entinostat|DRUG: Nivolumab|DRUG: CC-486 300
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults
Interventions: DRUG: epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3)|DRUG: gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8)|DRUG: trabectedin 1.3 mg/m2|DRUG: high-dose ifosfamide 14 g/m2, given in in 14 days|DRUG: etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3)|DRUG: gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empiric Calcium in Massive Transfusion
Status: NOT_YET_RECRUITING
Conditions: Hemorrhage|Trauma|Hypocalcemia|Shock, Hemorrhagic
Interventions: DRUG: Calcium Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: PRC supported text + AI driven CSDH-enhanced text|BEHAVIORAL: AI driven CSDH-enhanced text only|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multi-Strategy Intervention for Anesthesia Care of Obese Patients A Factorial Randomized Controlled Trial
Status: WITHDRAWN
Conditions: Obesity|Bariatric Surgery Candidate|Tracheal Intubation Morbidity|Nausea and Vomiting, Postoperative|Hyperglycemia Drug Induced|Gastric Reflux
Interventions: DRUG: Dexamethasone 8 mg|DIAGNOSTIC_TEST: Applied inspiratory pressure (10, 15, 20, or 25 cmH2O)|DEVICE: Tracheal intubation using video intubating stylet, video laryngoscopy, or direct laryngoscopy|DEVICE: Goal-directed hemodynamic therapy targeting cardiac index|DRUG: Placebo (0.9% sodium chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Catheter Primary Percutaneous Coronary Intervention Method in Patients With ST Elevation Myocardial Infarction
Status: ENROLLING_BY_INVITATION
Conditions: ST Elevation Myocardial Infarction
Interventions: DEVICE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nalbuphine as an Adjuvant to Levobupivacaine in Caudal Analgesia in Children
Status: COMPLETED
Conditions: Caudal Anesthesia
Interventions: PROCEDURE: caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rituximab Therapy in Anti-Myelin Associated Glycoprotein Patients With Characteristics of Good Responders
Status: RECRUITING
Conditions: Anti-MAG Neuropathy
Interventions: DRUG: Rituximab infusion|DRUG: Placebo infusion|DRUG: Premedications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT