pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability, Pharmacokinetic Characteristics, and Efficacy of CM369 in Advanced Solid Tumors & Hematologic Malignancies
Status: RECRUITING
Conditions: Advanced Solid Tumors and Hematologic Malignancies
Interventions: DRUG: CM369
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Study of Pharmacokinetics, Safety, Tolerability, and Efficacy of Intravenous Anti-Spike(s) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) for the Treatment of Pediatric Patients Hospitalized Due to COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: casirivimab+imdevimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Title: Effect of Therapeutic Touch on Daytime Sleepiness, Stress and Fatigue
Status: COMPLETED
Conditions: Stress|Fatigue|Sleepiness
Interventions: OTHER: Therapeutic Touch|OTHER: Control group|OTHER: Sham Therapeutic Touch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectivness of Distraction by Electric ride-on Cars for Peri Operative Anxiety in Ambulatory Pediatric Surgery
Status: COMPLETED
Conditions: Anxiety
Interventions: BEHAVIORAL: Using electric car
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Autogenous Vein Graft Failure in Coronary Artery Bypass Procedures
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: CGT003 (E2F Duplex Decoy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Metformin Treatment for Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: Metformin Hydrochloride|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of PRADO Heart Failure in Occitania
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: BEHAVIORAL: PRADO-IC|BEHAVIORAL: No intervervention Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ranibizumab Versus Low-fluence Photodynamic Therapy in the Treatment of Chronic Central Serous Chorioretinopathy
Status: COMPLETED
Conditions: Chronic Central Serous Chorioretinopathy
Interventions: DRUG: Verteporfin|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Protective Effect of Ginkgo Biloba Extract on Cisplatin-induced Ototoxicity in Humans
Status: COMPLETED
Conditions: Ototoxicity|Hearing Loss
Interventions: DRUG: Ginkgo Biloba Extract (GBE761)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Analysis of the Duration of Combination Therapy That is Necessary for HCV Genotype 1 Eradication
Status: COMPLETED
Conditions: Chronic Hepatitis C, HCV Genotype 1
Interventions: DRUG: Pegylated interferon-alfa2a (Pegasys); ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of TRU-016 Plus Bendamustine vs. Bendamustine in Relapsed Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: TRU-016 and bendamustine|DRUG: Bendamustine|DRUG: 15 mg/kg TRU-016 and bendamustine|DRUG: 20 mg/kg TRU-016 and bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Bifidobacterium Breve B-3 on Body Fat in Obese Adults
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium breve B-3|DIETARY_SUPPLEMENT: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Prospective Clinical Trial of Immediate Flap Closure Versus Wound Care for Management of Late-stage Pressure Ulcers
Status: WITHDRAWN
Conditions: Pressure Ulcer
Interventions: PROCEDURE: surgical reconstruction|PROCEDURE: wound management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Safety,Tolerability, PK and PD Of DA-1241 In Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Metformin|DRUG: DA-1241
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect
Status: WITHDRAWN
Conditions: Nicotine Dependence
Interventions: DRUG: Intravenous Nicotine|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Prospective Comparison of Fluoroscopic, Sonographic or Combined Approach for Renal Access in Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Urolithiasis
Interventions: PROCEDURE: US-guided renal access|PROCEDURE: Fluoroscopy-guided renal access|PROCEDURE: US combined with fluoroscopy-guided renal access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation
Status: TERMINATED
Conditions: Transient Tachypnea of the Newborn
Interventions: OTHER: High Flow Nasal Cannula|OTHER: Bubble Nasal CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase II Trial of Neoadjuvant Chemotherapy Compared With Chemoradiotherapy in Gastric Adenocarcinoma
Status: COMPLETED
Conditions: Stomach Neoplasms|Neoadjuvant Therapy|Chemoradiotherapy|Chemotherapy
Interventions: RADIATION: SIB-IMRT|DRUG: S-1|PROCEDURE: Surgery|DRUG: SOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microbiotic Product to Promote Microbiome Health and Improve Chemotherapy Delivery
Status: RECRUITING
Conditions: Metastatic Colon Carcinoma|Stage IV Colon Cancer AJCC v8|Stage IVA Colon Cancer AJCC v8|Stage IVB Colon Cancer AJCC v8|Stage IVC Colon Cancer AJCC v8
Interventions: DRUG: NBT-NM108
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery
Status: COMPLETED
Conditions: Opioid Use|Pain, Postoperative
Interventions: DRUG: Bupivacaine|DRUG: Dexamethasone|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Anesthetics and Surgery on Sleep Quality in Patients Undergoing Posterior Spinal Instrumentation Surgery
Status: COMPLETED
Conditions: Sleep Disturbance|Anesthesia; Adverse Effect
Interventions: PROCEDURE: Sevoflurane (Sevorane® liquid 100%, Abbvie Pharmaceuticals, Istanbul, Turkey)|PROCEDURE: Propofol (Propofol-PF® 1% (Polifarma Pharmaceuticals, Tekirdag, Turkey)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DE-111 Against Tafluprost Ophthalmic Solution 0.0015% Alone and Concomitant Use of Tafluprost Ophthalmic Solution 0.0015% Plus Timolol Ophthalmic Solution 0.5%
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: DE-111 ophthalmic solution|DRUG: Tafluprost ophthalmic solution 0.0015%|DRUG: Concomitant use of tafluprost ophthalmic solution 0.0015% plus timolol ophthalmic solution 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Epidural Steroid Injection Using Dexamethasone or Betamethasone
Status: COMPLETED
Conditions: Back Pain|Neck Pain
Interventions: DRUG: Dexamethasone|DRUG: Betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Accuracy of OPS™ Femoral Neck Resection Study
Status: COMPLETED
Conditions: Primary Total Hip Arthroplasty
Interventions: DEVICE: Primary Total Hip Replacement with Trinity cup and TriFit TS stem via posterolateral surgical approach.|DEVICE: Primary Total Hip Replacement with Trinity cup and MetaFix stem via direct anterior surgical approach
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Ischemic Heart Disease|Acute Coronary Syndromes
Interventions: DRUG: cilostazol in addition to aspirin and clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HCV Test and Treat Utilizing Simplified HCV Patient Education
Status: RECRUITING
Conditions: Hepatitis C
Interventions: DIAGNOSTIC_TEST: Cepheid POC HCV Viremia (RNA) test|OTHER: HCV education from a health care provider|DRUG: Glecaprevir and Pibrentasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of Next-generation CD19-UCART
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Non Hodgkin Lymphoma
Interventions: BIOLOGICAL: CD19-UCART
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole-body Vibration Versus Aerobic Exercise on the Inflammatory Status and Hormonal Parameters Premenstrual Syndrome
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: OTHER: whole body vibration|OTHER: aerobic exercise|OTHER: supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of GIP and GLP-2 in Postprandial Splanchnic Blood Flow Distribution and Metabolism
Status: COMPLETED
Conditions: Blood Flow
Interventions: OTHER: GIPR antagonist / study tool|OTHER: GLP-2R antagonist / study tool|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Implementing Precision Medicine Approaches to Guide Anti-platelet Selection
Status: UNKNOWN
Conditions: Acute Coronary Syndrome (ACS)|STEMI - ST Elevation Myocardial Infarction (MI)|NSTEMI - Non-ST Segment Elevation MI|Unstable Angina (UA)
Interventions: GENETIC: CYP2C19 genotyping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Isatuximab-based Therapy in Participants With Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: DRUG: isatuximab SAR650984|DRUG: cemiplimab REGN2810
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home-delivered Meals for Persons With Dementia: Which Model Delays Nursing Home Placement?
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: Bi-weekly frozen meal home delivery|BEHAVIORAL: Daily home meal delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses
Status: COMPLETED
Conditions: Aphakia
Interventions: DEVICE: Tecnis MF IOL|DEVICE: Crystalens AO IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Access Program for Zolbetuximab
Status: AVAILABLE
Conditions: Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma Cancer|Locally Advanced Unresectable Gastric Adenocarcinoma Cancer|Metastatic Gastric Adenocarcinoma Cancer|Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma
Interventions: DRUG: zolbetuximab
Study Type: EXPANDED_ACCESS
Clinical trial: CPI-613 in Treating Patients With Myelodysplastic Syndromes Who Failed Previous Therapy
Status: TERMINATED
Conditions: Previously Treated Myelodysplastic Syndromes
Interventions: DRUG: 6,8-bis(benzylthio)octanoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protocol to Minimize Injections and Blood Draws for Women Undergoing in Vitro Fertilization
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Menopur|DRUG: Synarel|DRUG: HCG trigger|DRUG: Clomiphene citrate|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
Status: WITHDRAWN
Conditions: Triple Negative Breast Cancer|Triple Negative Breast Neoplasms|Triple-Negative Breast Cancer
Interventions: BIOLOGICAL: Personalized synthetic long peptide vaccine (Poly ICLC)|DRUG: Poly ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Healthy Brain Development: Wellness for 2 Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Prenatal Stress
Interventions: BEHAVIORAL: Mothers and Babies (MB) Course|BEHAVIORAL: Just in Time Intervention (JITI) Content|DEVICE: Biostamp nPoint Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DRUG: MCI-186|DRUG: Placebo of MCI-186
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Glass-Ionomer Sealing Technique on Hypersensitive Teeth With Molar Incisor Hypomineralisation
Status: RECRUITING
Conditions: Hypersensitive|Molar Incisor Hypomineralization|Pit and Fissure Sealants
Interventions: COMBINATION_PRODUCT: GIC on MIH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Periodontal Treatment on Growth Differentiation Factor-15 Levels
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: OTHER: Full mouth Scaling and root planing|OTHER: Quadrant Scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of a New Drug for Type 2 Diabetes
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: GMC-252-L-Lysine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nutritional Products on Blood Glucose in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Nutritional Formula|OTHER: Usual diet|OTHER: Diabetes Meal Plan with experimental diabetes-specific nutritional shake, diabetes specific cereal, and diabetes specific snack bars.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate
Status: UNKNOWN
Conditions: Rhinitis|Nasal Obstruction|GERD
Interventions: DRUG: lansoprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of STYLAGE® XXL for Chin Augmentation in Chinese Adults
Status: COMPLETED
Conditions: Esthetic
Interventions: DEVICE: Stylage XXL at enrollment|DEVICE: Stylage XXL at Month 6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose of Cervarix Vaccine in Girls or Three Doses of Gardasil Vaccine in Women for the Prevention of Human Papillomavirus Infection, the PRIMAVERA-ESCUDDO Trial
Status: COMPLETED
Conditions: Human Papillomavirus-Related Cervical Carcinoma
Interventions: BIOLOGICAL: Quadrivalent Human Papillomavirus (types 6, 11, 16, 18) Recombinant Vaccine|BIOLOGICAL: Recombinant Human Papillomavirus Bivalent Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Extract of Curcuma Longa Complexed With Phosphatidilcholine(Motore®)in the Treatment of Adults With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Motore|DRUG: Alivium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists
Status: COMPLETED
Conditions: Solid Cancers
Interventions: DRUG: GDC-0449|DRUG: GDC-0449|DRUG: GDC-0449
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Siltuximab in Participants With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Siltuximab|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate of Cosmetic Benefit of a Moisturising Cream in People With Blemish Prone Skin
Status: COMPLETED
Conditions: Skin Care
Interventions: OTHER: Washout / Standard Cleanser|OTHER: Test product|OTHER: Positive control cleanser|OTHER: Positive control moisturiser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Anaesthetic Methods for Total Knee Replacement Surgery
Status: TERMINATED
Conditions: Total Knee Replacement
Interventions: PROCEDURE: Adductor Canal catheter delivering 0.0625% L- Bupivacaine|PROCEDURE: Femoral nerve catheter delivering 0.0625% L- Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of the Immune Response to Hepatitis B in 4-6 Years Old Children Previously Vaccinated With DTPa-HBV-IPV/Hib
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: hepatitis B vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nelfinavir and Lenalidomide/Dexamethasone in Progressive Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Nelfinavir|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effect of Malt Extract Versus Sucrose on the Response of Glucose and Insulin, Subjective Appetite Sensations and ad Libitum Energy Intake
Status: COMPLETED
Conditions: Obesity|Diabetes
Interventions: OTHER: The acute effect of malt extract versus sucrose on the response of glucose and insulin, subjective appetite sensations and ad libitum energy intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Short-term Psychodynamic Psychotherapy in Serious Physical Illness
Status: RECRUITING
Conditions: Malignant Neoplasm|Carcinoma|Palliative Care
Interventions: BEHAVIORAL: Short-term psychodynamic psychotherapy for patients with serious physical illness (ORPHYS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Glycopyrronium in Axillary Hyperhydrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: glycopyrronium Topical Wipes|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recurrent Laryngeal Nerve's Motor Function: Sometimes Motor Fibers May Also Be Located in The Posterior Branch
Status: COMPLETED
Conditions: Recurrent Laryngeal Nerve Injuries
Interventions: DEVICE: intraoperative neuromonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acrysof Toric SN60T3corneal Astigmatism Between 0.75 and 1.00 D.
Status: COMPLETED
Conditions: Cataracts
Interventions: DEVICE: The Acrysof toric SN60T3 IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Laboratory-Treated T Cells and Ipilimumab in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: BIOLOGICAL: ipilimumab|DRUG: cyclophosphamide|PROCEDURE: biopsy|BIOLOGICAL: aldesleukin|OTHER: immunohistochemistry staining method|GENETIC: polymerase chain reaction|OTHER: immunoenzyme technique|BIOLOGICAL: therapeutic cytotoxic T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Use of Celecoxib in Patients With Intraductal Papillary Mucinous Neoplasms (IPMNs)
Status: TERMINATED
Conditions: Pancreas Neoplasms
Interventions: DRUG: COX-2 Inhibitor 6-8 weeks prior to surgery|DRUG: COX-2 Inhibitor for 6 months prior to follow-up EUS or ERCP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study of Substance P-Saporin in Terminal Cancer Patients With Intractable Pain
Status: COMPLETED
Conditions: Terminally Ill|Histologically-confirmed Advanced Cancer|Pain, Intractable
Interventions: DRUG: Substance P-Saporin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Education for Patients With Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Patient Education|IBS - Irritable Bowel Syndrome
Interventions: BEHAVIORAL: Structured patient group education|BEHAVIORAL: Education via Internet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Ozone (O2-O3) Injections in the Treatment of Myofascial Pain Syndrome
Status: COMPLETED
Conditions: Myofascial Pain Syndrome|Myofascial Trigger Point Pain
Interventions: PROCEDURE: Ozone therapy|PROCEDURE: Lidocaine injection group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.
Status: COMPLETED
Conditions: Prosthesis-related Infections|Wound Complications|Joint Diseases|Musculoskeletal Diseases
Interventions: DEVICE: Prevena
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Post Operative Bone Loss in Children
Status: COMPLETED
Conditions: Osteoporosis|Cerebral Palsy|Spina Bifida|Osteopenia|Osteogenesis Imperfecta
Interventions: DRUG: pamidronate|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acceptability Assessment of an "Organization of Care Integrating Artificial Intelligence and a Solution of Telemedicine" on Care of the Nursing Home Residents Located in a Medical Desert: Pilot Study INTEL@MED-POC
Status: UNKNOWN
Conditions: Homes for the Aged
Interventions: OTHER: Telemedecine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Lung Non-Small Cell Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Stage I Lung Cancer AJCC v8|Stage I Ovarian Cancer AJCC v8|Stage IA Ovarian Cancer AJCC v8|Stage IA1 Lung Cancer AJCC v8|Stage IA2 Lung Cancer AJCC v8|Stage IA3 Lung Cancer AJCC v8|Stage IB Lung Cancer AJCC v8|Stage IB Ovarian Cancer AJCC v8|Stage IC Ovarian Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage II Ovarian Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIA Ovarian Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8|Stage IIB Ovarian Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIA Ovarian Cancer AJCC v8|Stage IIIA1 Ovarian Cancer AJCC v8|Stage IIIA2 Ovarian Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIB Ovarian Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IIIC Ovarian Cancer AJCC v8
Interventions: DRUG: Chemotherapy|OTHER: Functional Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Macugen(Pegaptanib)on Surgical Outcomes and VEGF Levels in Diabetic Patients With PDR (Diabetic Retinopathy or CSDME (Macular Edema)
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: Macugen (pegaptanib)|DRUG: Macugen (Pegaptanib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prostate Cancer Detection Using the Stockholm3 Test and MR/Fusion Biopsies
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: MRI/Fusion biopsies|PROCEDURE: Systematic biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NIvolumab COmbination With Standard First-line Chemotherapy and Radiotherapy in Locally Advanced Stage IIIA/B Non-Small Cell Lung Carcinoma
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Stage III
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Short Pulsed 1064 nm Nd-YAG Laser Versus 10600 nm Fractional CO2 Laser in Treatment of Striae Alba
Status: UNKNOWN
Conditions: Striae Distensae|Striae; Albicantes|Striae Alba|Nd-YAG Laser|Fractional CO2 Laser|High Frequency Skin Ultrasound|Short Pulsed Nd-YAG|Carbon Dioxide Laser|Neodymium-Doped Yttrium Aluminum Garnet Laser
Interventions: DEVICE: Laser|DEVICE: Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mitoxantrone Hydrochloride Liposome Injection in Patients With Advanced HER2 Negative Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 'Go With the Flow': Effects of Mindful Self-Compassion in Psychiatric Rehabilitation
Status: COMPLETED
Conditions: Meditation|Progressive Muscle Relaxation
Interventions: BEHAVIORAL: Mindful Self-Compassion|BEHAVIORAL: Progressive Muscle Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Fixed Combinations of Brimonidine/Timolol and Dorzolamide/Timolol in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination|DRUG: dorzolamide hcl 2%/ timolol maleate 0.5% fixed combination|DRUG: brimonidine tartrate 0.2%/timolol maleate 0.5% fixed combination as adjunctive to current prostaglandin therapy.|DRUG: dorzolamide hcl 2%/timolol maleate 0.5% fixed combinatin as adjunctive to current prostaglandin therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Importance of GLP-1 in Post RYGB Improvement in Glycaemic Control Type 2 Diabetic Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: SYN-004 Safety and Tolerability in Allo-HCT Subjects
Status: RECRUITING
Conditions: 121121000119106, Acute Graft-versus-host Reaction Following Bone Marrow Transplant (Disorder)
Interventions: BIOLOGICAL: SYN-004, Ribaxamase or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Multimodal Neuroimaging of Treatment Effects in Adolescent Mania
Status: COMPLETED
Conditions: Mania|Bipolar Disorder
Interventions: DRUG: Quetiapine & Placebo|DRUG: Lithium and Placebo|OTHER: Healthy Controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: NAION Treatment With Oral Prednisolone and Erythropoietin Injection
Status: UNKNOWN
Conditions: Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Interventions: DRUG: Oral prednisolone administration 50 mg|DRUG: Intravenous Erythropoietin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Saffron Extract on Sleep Quality and Stress
Status: COMPLETED
Conditions: Insomnia|Stress
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Saffron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
Status: RECRUITING
Conditions: Air Pollution|Atherosclerosis
Interventions: DEVICE: HEPA filtration|DEVICE: Sham filtration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Improving Sleep After TKA Using Mirtazapine and Quetiapine
Status: NOT_YET_RECRUITING
Conditions: Osteo Arthritis Knee|Insomnia
Interventions: DRUG: Mirtazapine|DRUG: Quetiapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-masked, Sham-controlled Phase 4 Study, Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept With Adjunctive Photodynamic Therapy in Patients With Polypoidal Choroidal Vasculopathy
Status: COMPLETED
Conditions: Polypoidal Choroidal Vasculopathy
Interventions: DRUG: Intravitreal Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Accuracy of a Personal Heart Rhythm Monitor to Detect Prolonged Paroxysmal Atrial Fibrillation
Status: WITHDRAWN
Conditions: Paroxysmal Atrial Fibrillation|Stroke
Interventions: DEVICE: Personal Heart Rhythm Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of RIvaroxaban for Prevention of Venous Thromboembolism After Knee Arthroscopy
Status: COMPLETED
Conditions: Venous Thromboembolism|Haemorrhage
Interventions: DRUG: Rivaroxaban|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: HLX35(EGFR×4-1BB Bispecific) in Patients With Advanced or Metastatic Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors|Squamous-cell Non-small Cell Lung Cancer
Interventions: DRUG: HLX35
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PENG Block vs. Intraoperative Local Anesthetic Infiltration for Total Hip Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Anesthesia
Interventions: PROCEDURE: PENG Block|PROCEDURE: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBI
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury|Posttraumatic Stress Disorders|Depression
Interventions: BEHAVIORAL: Multifamily Group for mTBI for Couples|BEHAVIORAL: Group Health Education (GHE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Examination of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Patients With Type II Diabetes
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: olmesartan medoxomil|DRUG: Olmesartan medoxomil plus Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Preoperative Chewing Gum on Anxiety and Sore Throat in Patients With Laryngeal Mask Airway
Status: ENROLLING_BY_INVITATION
Conditions: Laryngeal Mask|Throat Pain|Anxiety
Interventions: OTHER: Chewing Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study for Participants With Advanced, Not Amenable to Surgery, or Metastatic Lung Cancer Comparing Treatment With Pemetrexed + Cisplatin + Enzastaurin Versus Pemetrexed + Cisplatin + Placebo
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: enzastaurin|DRUG: pemetrexed|DRUG: cisplatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inflammation and Cardiovascular Health in Women
Status: COMPLETED
Conditions: HIV/AIDS|Myocardial Infarction
Interventions: RADIATION: Cardiac PET|RADIATION: 99mTc-tilmanocept SPECT/CT|RADIATION: Contrast Enhanced Coronary and Aortic Computed Tomography Angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low-Level Transcutaneous Vagus Stimulation in ST Segment Elevation Myocardial Infarction: TREAT MI Study
Status: WITHDRAWN
Conditions: STEMI - ST Elevation Myocardial Infarction|Inflammation
Interventions: DEVICE: Tragus stimulator|DEVICE: Sham Tragus stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eletriptan Provides Consistent Migraine Relief: Results Of A Within-Patient Multiple-Dose Study
Status: COMPLETED
Conditions: Migraine Without Aura|Migraine With Aura
Interventions: DRUG: Placebo|DRUG: Eletriptan HBr 40 mg|DRUG: Eletriptan HBr 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biologically Assisted Core Decompression of the Femoral Head Using the PerFuse Instrument and BioCUE
Status: UNKNOWN
Conditions: Avascular Necrosis of the Femoral Head
Interventions: DEVICE: PerFuse Percutaneous Decompression System|DEVICE: BioCUE Platelet Concentration System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Open-label Phase III Trial of Mapisal® Versus an Urea Hand-foot Cream as Prophylaxis for Capecitabine-induced Hand-foot Syndrome in Patients With Gastrointestinal Tumors or Breast Cancer
Status: NO_LONGER_AVAILABLE
Conditions: the Treatment Hand-foot Syndrome Patients With Gastrointestinal Tumors or Breast Cancer, Who Are Treated With Capecitabine
Interventions: DEVICE: Mapisal|OTHER: Urea hand-foot cream
Study Type: EXPANDED_ACCESS
Clinical trial: Safety and Immunogenicity of a Mycobacterium Tuberculosis Vaccine M72/AS01E in Participants With Well-controlled HIV
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: BIOLOGICAL: M72/AS01E Mycobacterium tuberculosis vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Iloprost in Adults With Abnormal Pulmonary Pressure and Associated With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Pulmonary Fibrosis|Pulmonary Hypertension
Interventions: DRUG: Iloprost Inhalation Solution (Ventavis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers
Status: RECRUITING
Conditions: Anxiety|Distress, Emotional|Effects of Vibration|Healthy
Interventions: OTHER: Neuvana 2.0 Transcutaneous Auricular Vagal Nerve Stimulation (TaVNS)|OTHER: Waitlist Control|OTHER: Healthy Controls: Substudy Group III|OTHER: Distressed Workers: Subgroup II
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Isosorbide Mononitrate in Induction of Labour
Status: UNKNOWN
Conditions: Labor Fast
Interventions: DRUG: Isosorbide Mononitrate 40 MG|DRUG: Isosorbide Mononitrate 60 MG|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab/Bendamustine + Rituximab/Cytarabine for Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Rituximab|DRUG: Bendamustine|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety And Tolerability Study Of RN6G In Subjects With Geographic Atrophy Secondary to Age-related Macular Degeneration
Status: TERMINATED
Conditions: Age-Related Maculopathy
Interventions: BIOLOGICAL: RN6G|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epidural Steroid Injection Versus Epidural Steroid Injection and Manual Physical Therapy and Exercise in the Management of Lumbar Spinal Stenosis
Status: COMPLETED
Conditions: Lumbar Spinal Stenosis
Interventions: OTHER: Epidural steroid injection plus physical therapy|OTHER: Epidural steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Haemocomplettan® P During Elective Complex Cardiac Surgery
Status: COMPLETED
Conditions: Fibrinogen Deficiency in Complex Cardiac Surgery
Interventions: DRUG: Haemocomplettan® P|DRUG: Human albumin (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MTBVAC Study in Adults With and Without Latent Tuberculosis Infection in South Africa
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: MTBVAC|BIOLOGICAL: BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Safety and Effectiveness of the InnAVasc Graft for Dialysis Access in Patients With Kidney Failure
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Failure, Chronic|Renal Dialysis
Interventions: DEVICE: InnAVasc arteriovenous graft surgical implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Epidermolysis Bullosa (Phase III, Cross-over)
Status: RECRUITING
Conditions: Epidermolysis Bullosa
Interventions: DRUG: allo-APZ2-OTS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate The Safety, Tolerability And Immunogenicity Of 4 mg Of ITI-3000 In Patients With Polyomavirus-Positive Merkel Cell Carcinoma (MCC)
Status: COMPLETED
Conditions: Merkel Cell Carcinoma
Interventions: DRUG: ITI-3000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assess Efficacy and Safety of AZD6244 in Combination With Docetaxel in Patients Receiving Second Line Non Small Cell Lung Cancer Treatment.
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV
Interventions: DRUG: Selumetinib 75 mg|DRUG: Docetaxel 75 mg/m2|DRUG: Docetaxel 60 mg/m2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Status: RECRUITING
Conditions: Schizophrenia|Cannabis Dependence|Prodromal for Psychotic Illness|Family History of Alcoholism|Healthy Control|Opioid-use Disorder|Post Traumatic Stress Disorder
Interventions: RADIATION: [11-C]OMAR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of PEG Solutions With and Without Electrolytes in the Treatment of Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Polyethylene glycol 4000|DRUG: Polyethylene glycol 4000 with electrolytes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT