pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacokinetics and Safety Comparison of Tiotropium Inhalation Powder Administered as the Bromide Salt From Hard Polyethylene Capsule Via the HandiHaler® 2 and Spiriva® HandiHaler® in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium low dose|DRUG: Tiotropium medium dose|DRUG: Spiriva® HandiHaler® high dose|DRUG: Placebo via the blue HandiHaler®|DRUG: Placebo via the grey HandiHaler®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PK Linearity and Steady State PK of CHF 6532 in Healthy Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D|DRUG: Treatment E|DRUG: Treatment F
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Human Electrophysiological Model to Quantify the CGRP-related Axon Reflex of Trigeminal Afferents
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine
Interventions: DIAGNOSTIC_TEST: High frequency stimulation (HFS)|DIAGNOSTIC_TEST: Low-frequency sinusoidal transcutaneous stimulation (sLFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cohort Assessing the Immunogenicity and the Safety of the COVID-19 Vaccine Janssen in Healthy Volunteers Based on 2 Age Groups: 65 Years or Older - 55 to 65 Years. Covicompare-Janssen
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: COVID-19 Vaccine Janssen (Ad26.COV2-S)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Effects of Multiple Doses of Mipomersen (200 mg SC) on the Pharmacodynamics and Pharmacokinetics of Single-dose Warfarin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: warfarin sodium|DRUG: mipomersen sodium; warfarin sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Placebo-Controlled Trial Of Pregabalin In Patients With Fibromyalgia.
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: pregabalin|DRUG: pregabalin|DRUG: pregabalin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of Kinesiotherapy Exercises With Cervical Mobilization in Cervicobrachial Neuralgia
Status: RECRUITING
Conditions: Cervico-Brachial Neuralgia
Interventions: PROCEDURE: kinesiotherapy exercises with cervical mobilization|PROCEDURE: cervical Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Bevacizumab in Preventing Acute Respiratory Distress Syndrome (ARDS)
Status: WITHDRAWN
Conditions: Severe Sepsis|Acute Respiratory Distress Syndrome
Interventions: DRUG: Bevacizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of YL-13027 in Combination With Gemcitabine and Nab-paclitaxel in Patients With Refractory Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Nab-paclitaxel|DRUG: YL-13027
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REducing Stress and Improving professionaLs' vItality Using innovativE iNtervenTions
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health Issue|Healthy Lifestyle|Stress, Psychological
Interventions: OTHER: Your World|OTHER: Control app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interleukin-2 Plus Anti-HIV Therapy in HIV-Infected Children With Weakened Immune Systems
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed|BIOLOGICAL: Diphtheria and Tetanus Toxoids Adsorbed|BIOLOGICAL: Tetanus and Diphtheria Toxoids Adsorbed|DRUG: Bacteriophage phi X 174|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Diagnostic Performances of Preoperative Echo-guided Uterine Biopsy in the Management of Suspect Uterine Sarcoma Tumors (BIOPSAR)
Status: NOT_YET_RECRUITING
Conditions: Fibroid Uterus|Sarcoma Uterus
Interventions: PROCEDURE: Echo-guided uterine biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparative Investigation of Standard Of Care (SOC) and Episil® in Combination Versus SOC Alone on Oral Mucositis
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DEVICE: episil(R)|OTHER: Oral hygiene procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Trial of Two Hypofractionated Radiotherapy Regimens Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children
Status: COMPLETED
Conditions: Pediatric Brain Stem Glioma
Interventions: RADIATION: Hypofractionated Arm (1)|RADIATION: Hypofractionated Arm (2)|RADIATION: Conventional Arm (3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Long-term Immunogenicity of an Inactivated Split-virion 2009 Pandemic Influenza A H1N1 Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: split-virion, non-adjuvanted H1N1 vaccine of 15 μg|BIOLOGICAL: split-virion, non-adjuvanted H1N1 vaccine of 30 μg|BIOLOGICAL: split-virion, non-adjuvanted H1N1 vaccine of 45 μg|BIOLOGICAL: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Compatibility of a Mild, Moisturizing Hand Cleanser for Patients With Mild to Moderate Hand Dermatitis
Status: COMPLETED
Conditions: Hand Dermatosis
Interventions: OTHER: Mild, moisturizing hand cleanser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Affirmative Psychotherapy for Sexual Minority Women's Mental and Behavioral Health
Status: RECRUITING
Conditions: Heavy Drinking|Mental Health Issue
Interventions: BEHAVIORAL: LGBTQ-affirmative Cognitive Behavioral Therapy|BEHAVIORAL: LGBTQ-affirmative Treatment-As-Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AZA + Venetoclax as Maintenance Therapy in Patients With AML in Remission
Status: RECRUITING
Conditions: Acute Myeloid Leukemia in Remission|FLT3 Gene Mutation|Hematologic and Lymphocytic Disorder|Acute Myeloid Leukemia|Minimal Residual Disease Persistence|Therapy-Related Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Hyperbaric Oxygen Therapy to Improve Umbilical Cord Blood Stem Cell Homing and Subsequent Engraftment
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndrome (MDS)|Hodgkins Lymphoma|Non-Hodgkins Lymphoma
Interventions: DEVICE: Administration of hyperbaric oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compatible Effect of Remimazolam Besylate Combined With Afentanil for ATI
Status: RECRUITING
Conditions: Remimazolam|Awake Endotracheal Intubation
Interventions: DRUG: Dos of Afentanil 20|DRUG: Dos of Afentanil 30|DRUG: Dos of Afentanil 40|DRUG: Dos of Afentanil 50|DRUG: Dos of Afentanil 60|DRUG: Dos of Afentanil 70|DRUG: Dos of Afentanil 80|DRUG: Dos of Afentanil 90|DRUG: Dos of Afentanil 100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons
Status: RECRUITING
Conditions: Traumatic Brain Injury|Mild Traumatic Brain Injury|Alzheimer's Disease|Brain Injury Traumatic Moderate|Brain Injury Traumatic Severe|Dementia
Interventions: BEHAVIORAL: Group Wellness Class 1|BEHAVIORAL: Group Wellness Class 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Central Mammary Duct Excision; How to Improve the Outcome?
Status: COMPLETED
Conditions: Duct Ectasia Breast|Benign Breast Disease
Interventions: PROCEDURE: major duct excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Integration Success of an Implant System With a Novel Abutment Attachment Design in Immediate Loading Cases
Status: COMPLETED
Conditions: Partial Edentulism|Tooth Disease
Interventions: DEVICE: New Abutment Connection implant|DEVICE: Nanotite Certain Tapered implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
Status: RECRUITING
Conditions: Cerebral Adrenoleukodystrophy (cALD)
Interventions: DRUG: Leriglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC)
Status: RECRUITING
Conditions: Malaria|Malaria,Falciparum
Interventions: OTHER: Seasonal Malaria Chemoprophylaxis (under 5 year old) implemented by the MoH without DOT|OTHER: Seasonal Malaria Chemoprophylaxis (under 5 years old) with DOT|OTHER: Seasonal Malaria Chemoprophylaxis (under 10 years old) with DOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients
Status: RECRUITING
Conditions: Septic Shock|Mechanical Ventilation Complication
Interventions: DRUG: Esketamine|DRUG: Saline|DRUG: Remifentanil + propofol|PROCEDURE: Pain and Sedation Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of Surgery and Radiotherapy After SHR-1316 (Adebrelimab) and Platinum-containing Doublet Induction Therapy for Limited-stage Small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Limited Stage Small Cell Lung Cancer
Interventions: COMBINATION_PRODUCT: chemotherapy and SHR-1316(Adebrelimab) comnined with surgery or radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Living in Fitness Together (LIFT): Testing an Innovative Fall Prevention Program
Status: COMPLETED
Conditions: Accidental Falls
Interventions: BEHAVIORAL: Group-based exercise and peer coaching|OTHER: Usual PT and attention control grp class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effect Study of Acupuncture for Anorexia in Patients With Gastrointestinal Tract and Lung Cancers
Status: UNKNOWN
Conditions: Anorexia|Cancer Cachexia
Interventions: OTHER: Acupuncture|OTHER: Sham Acupuncture|DRUG: Megestrol Acetate|DRUG: Placebo(Megestrol Acetate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Parenting Skills as a Novel Target for Improving Pediatric Medication Adherence: Study 3
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: BEHAVIORAL: CareMeds Intervention|BEHAVIORAL: Usual Care Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Symptoms, Complications and Side Effects of Adding Medications Continuously To Subcutaneous Infusion (Hypodermoclysis) In Home Care Hospice Patients
Status: COMPLETED
Conditions: Home Infusion Therapy|Infusion Pumps
Interventions: DEVICE: syringe driver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of αPD1-MSLN-CAR T Cells to Evaluate the Safety, Tolerability, and Effectiveness for Patients With MSLN-positive Advanced Solid Tumors
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries
Status: UNKNOWN
Conditions: Spinal Stenosis|Intervertebral Disc Displacement
Interventions: DRUG: Wound topically irrigated with 500mg TXA|DRUG: 1mg/kg/hr TXA intravenous infusion till the last suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD19-CAR-T2 Cells for CD19 Positive B Cell Malignancies
Status: COMPLETED
Conditions: B Cell Leukemia|B Cell Lymphoma
Interventions: BIOLOGICAL: CD19-CAR-T2 Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protective Effects of Long-term Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
Status: COMPLETED
Conditions: Carotid Artery Stenosis
Interventions: PROCEDURE: Remote ischemic preconditioning|PROCEDURE: Sham remote ischemic preconditioning|PROCEDURE: Carotid Artery Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spatial and Ocular Trajectories for the Early Diagnosis of Alzheimer's Disease.
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Aging
Interventions: DIAGNOSTIC_TEST: Cognitive assessment|OTHER: Questionnaires|DEVICE: Spatial navigation task with eye-tracking.|BIOLOGICAL: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS
Status: COMPLETED
Conditions: Sepsis
Interventions: DIAGNOSTIC_TEST: GFR by Iohexol|DIAGNOSTIC_TEST: Urine Collection|DIAGNOSTIC_TEST: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence Study of Zonisamide Capsules 100 mg of Dr.Reddy's Laboratories Limited Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zonisamide|DRUG: Zonegran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal MRI-guided rTMS to Treat Refractory Hallucinations
Status: COMPLETED
Conditions: Hallucinations|Schizophrenia|Perceptual Disorders
Interventions: DEVICE: MagPro X100 repetitive Transcranial Magnetic Stimulation|DEVICE: MagPro X100 repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CART19 to Treat B-Cell Leukemia or Lymphoma That Are Resistant or Refractory to Chemotherapy
Status: COMPLETED
Conditions: Hematopoietic/Lymphoid Cancer|Adult Acute Lymphoblastic Leukemia in Remission|B-cell Adult Acute Lymphoblastic Leukemia|B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma
Interventions: BIOLOGICAL: CART-19
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Safety and Efficacy of Dupilumab in Children With Asthma (Liberty Asthma Excursion)
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: DRUG: Dupilumab (SAR231893/REGN668)|DRUG: Asthma controller therapies (incl. prednisone/prednisolone)|DRUG: Asthma reliever therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urolithin A Supplementation in Middle-aged Adults With Obesity
Status: RECRUITING
Conditions: Obesity|Vascular Dementia|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Urolithin A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mindfulness Based Eating Awareness Training for Bariatric Surgery Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Morbid|Eating Disorder Symptom
Interventions: BEHAVIORAL: Mindfulness Based Eating and Awareness Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes in Adult Patients Undergoing Laparoscopic Surgery Under Neuraxial Anesthesia
Status: ENROLLING_BY_INVITATION
Conditions: Mortality|Surgical Complication|Neurological Complication|Respiratory Complication|Cardiovascular Complication|Nephrotoxicity|Metabolic Complication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sonographic Examination of Renal Function in Individuals With Long-term Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries|Renal Insufficiency
Interventions: DIAGNOSTIC_TEST: renal scintigraphy|DIAGNOSTIC_TEST: renal doppler sonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Small Cell Lung Cancer (SCLC)
Interventions: DRUG: Tarlatamab|DRUG: Lurbinectedin|DRUG: Topotecan|DRUG: Amrubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries
Status: TERMINATED
Conditions: Metabolic Diseases|Endocrine System Diseases|Heart Disease|Vascular Diseases|Diabetes|Cardiovascular Disease|Glucose Metabolism Disorders|Hypertension
Interventions: DRUG: Omega-3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Upregulation of PSMA Receptors After Androgen Deprivation Therapy on PSMA PET/CT Imaging in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PSMA PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Neural Substrates of Alcohol Craving by High-resolution Electroencephalography
Status: WITHDRAWN
Conditions: Alcoholism|Alcohol Dependence
Interventions: BEHAVIORAL: Induction of alcohol craving|OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Multiple Myeloma
Interventions: RADIATION: total body irradiation|DRUG: Thiotepa|DRUG: Cyclophosphamide|DRUG: Busulfan|DRUG: Melphalan|DRUG: Fludarabine|DRUG: Clofarabine|PROCEDURE: (CliniMACS) T-cell depleted PBSC Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacist-Led Study in Controlling Hypoglycemia in Older Adults With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2 With Hypoglycemia
Interventions: BEHAVIORAL: SUGAR Handshake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Almonertinib Combined With Stereotactic Body Radiotherapy (SBRT) in the Treatment of Non-small Cell Lung Cancer With EGFR Sensitive Mutation: a Single-arm, Open-label Clinical Trial
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: stereotactic ablative body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combined Portfolio Diet and Exercise Study
Status: COMPLETED
Conditions: Cardiovascular Diseases|Hypercholesterolemia|Type 2 Diabetes|Metabolic Syndrome
Interventions: BEHAVIORAL: Portfolio diet and structured exercise|BEHAVIORAL: DASH-like diet and structured exercise|BEHAVIORAL: Portfolio diet and routine exercise|BEHAVIORAL: DASH-like diet and routine exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma
Status: COMPLETED
Conditions: Melasma
Interventions: DRUG: Fluocinolone acetonide 0.1%/hydroquinone 4%/tretinoin 0.05% Cream in sequence with glycolic acid peels
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis of Periprosthetic Joint Infections With Calcium Sulfate Beads in Patients With Non-modifiable Risk Factors.
Status: COMPLETED
Conditions: Infection
Interventions: DEVICE: Antibiotic local prophylaxis with medicated calcium sulfate beads|PROCEDURE: Classical parenteral antibiotic prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bortezomib in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Adult Lymphocyte Depletion Hodgkin Lymphoma|Adult Mixed Cellularity Hodgkin Lymphoma|Adult Nodular Sclerosis Hodgkin Lymphoma|Recurrent Adult Hodgkin Lymphoma
Interventions: DRUG: 17-N-allylamino-17-demethoxygeldanamycin/bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Participants With Traumatic Brain Injury
Status: COMPLETED
Conditions: Neurobehavioral Disinhibition
Interventions: DRUG: Placebo|DRUG: AVP-786-28|DRUG: AVP-786-42.63
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Access for Minimally-invasive Leadless Pacemaker Implantation Through the Right Jugular routE
Status: ENROLLING_BY_INVITATION
Conditions: Leadless Pacemaker|Same-day Discharge
Interventions: DEVICE: Leadless pacemaker implantation through right internal jugular vein
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Anyu Peibo With Placebo in Treatment of MDD
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: Anyu Peibo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-VEGF Instead of Intraoperative PRP in Proliferative Diabetic Retinopathy
Status: UNKNOWN
Conditions: Anti-VEGF|Proliferative Diabetic Retinopathy|PRP|Vitrectomy
Interventions: PROCEDURE: anti-VEGF|PROCEDURE: PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Reducing Blood Loss in Patients With Pelvic Tumors Undergoing Hemipelvectomy Surgery
Status: RECRUITING
Conditions: Pelvic Mass
Interventions: PROCEDURE: Hemipelvectomy|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cryoballoon Pulmonary Vein Isolation Including Associated Esophageal Effects
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: Esophageal Temperature-Guided Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Macitentan-tadalafil Fixed Dose Combination Tablet Relative to the Concomitant Administration of the Reference Tablets of Macitentan and Tadalafil in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: COMBINATION_PRODUCT: Macitentan / tadalafil FDC|DRUG: Macitentan (Opsumit®)|DRUG: Tadalafil (Adcirca®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Proton Beam Radiation With Concurrent Chemotherapy and Nelfinavir for Inoperable Stage III Non Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Nelfinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Kinesio Taping in Musculoskeletal Neck Pain
Status: UNKNOWN
Conditions: Musculoskeletal Neck Pain
Interventions: OTHER: Kinesio taping|OTHER: Conventional bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thrombocytopenia (ITP)
Status: RECRUITING
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Rilzabrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Register for Patients With Thyroid Hormone Resistance.
Status: RECRUITING
Conditions: Hypothyroidism|Global Developmental Delay|Intellectual Disability|Dystonia|Muscle Hypotonia|Seizures|Allan-Herndon-Dudley Syndrome|Microcephalus
Interventions: OTHER: no intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Bevacizumab on the Trabeculectomy
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DRUG: intraocular injections of bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT)
Status: COMPLETED
Conditions: Stem Cell Transplantation|Ventricular Dysfunction, Left
Interventions: BIOLOGICAL: Autologous human mesenchymal cells (hMSCs)|BIOLOGICAL: Autologous human bone marrow cells (hBMCs)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Radiofrequency Ablation Versus Repeat Hepatectomy for Recurrent Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: HR|PROCEDURE: RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: ADVAIR DISKUS™ 250/50mcg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mitoxantrone, Etoposide, and Cytarabine (MEC) Plus Lenalidomide for Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: AML
Interventions: DRUG: Etoposide|DRUG: Cytarabine|DRUG: Lenalidomide|DRUG: Mitoxantrone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Mental and Physical Health of Women Veterans
Status: RECRUITING
Conditions: Cardiovascular Diseases|Overweight|Obesity|Smoking|Hypertension|Cholesterol|Diabetes Mellitus|Prediabetic State|Pregnancy|Depression, Postpartum|Prevention|Implementation Science|Quality Improvement|Virtual Care
Interventions: BEHAVIORAL: EBQI|BEHAVIORAL: REP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Content, Bioavailability and Health Effects of Trace Elements and Bioactive Components in Organic Agricultural Systems
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Organic or conventional diet|OTHER: Diet (organic or conventional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study of Effects of Ticagrelor on Microparticles and Micro-RNA in NSTE-ACS
Status: TERMINATED
Conditions: Non ST Segment Elevation Acute Coronary Syndrome
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pregnant Women's Maneuvers on Pregnancy Distress and Perception of Maternity Role"
Status: COMPLETED
Conditions: Pregnancy Related|Mother-Child Relations
Interventions: OTHER: I and II. Performing Leopold Maneuvers by the pregnant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Sitagliptin for the Treatment of Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Insulin (MK-0431-260)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Comparator: Placebo|BIOLOGICAL: Insulin Glargine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thoraflex Hybrid Post-Market Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Aortic Dissection|Aortic Rupture|Penetrating Aortic Ulcer|Aortic Dissection|Aortic Aneurysm, Thoracic
Interventions: BEHAVIORAL: EQ-5D-5L QOL questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety, Dose Conversion, and Dose Individualization of Duragesic® (Fentanyl Transdermal Patch) in the Treatment of Children With Chronic Pain Requiring Narcotic Pain Relief Therapy
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: DuragesicÂ® (fentanyl) Therapeutic Transdermal System (TTS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of UCon Bar Electrode for the Treatment of Overactive Bladder (OAB) and Bowel Dysfunction (BD)
Status: RECRUITING
Conditions: Urinary Incontinence|Urinary Incontinence, Urge|Fecal Incontinence|Fecal Incontinence With Fecal Urgency|Nocturia|Urinary Frequency More Than Once at Night|Bowel Disorders Functional|Incontinence, Nighttime Urinary
Interventions: DEVICE: UCon-Bar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study Comparing Compounded Topical Pain Creams vs. Placebo for Treating Pain Symptoms
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Neuropathic pain cream|OTHER: Nociceptive pain cream|OTHER: Mixed pain cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Antidepressants and Attention Bias Modification in Depression
Status: RECRUITING
Conditions: Depressive Disorder
Interventions: BEHAVIORAL: Attentional Bias Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Exercise Training or Multidisciplinary Treatment in Extremely Obese Adolescents
Status: COMPLETED
Conditions: Obesity|Cardiovascular Diseases
Interventions: BEHAVIORAL: intensity controlled interval training (AIT)|BEHAVIORAL: Multidisciplinary approach (MTG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab Plus Olaparib in LA-HNSCC
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Olaparib|DRUG: Cisplatin|RADIATION: IMRT (intensity modulated radiation therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Postoperative Intracranial Pressure in Patients Undergoing Intracranial Tumor Surgery
Status: NOT_YET_RECRUITING
Conditions: INTRACRANIAL TUMOR|INTRACRANIAL PRESSURE|OPTIC NERVE
Interventions: PROCEDURE: USG|PROCEDURE: BCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Omitting of Internal Mammary Irradiation Among Early Stage Intermediate Risk (N1) Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: omit of IMI group|RADIATION: IMI group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Curcumin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Virtual Reality and Progressive Muscle Relaxation on Anxiety and Attention Among Cardiac Care Unit Patients
Status: NOT_YET_RECRUITING
Conditions: Anxiety
Interventions: OTHER: Modified Progressive Muscle Relaxation Exercise|DEVICE: The virtual reality box
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the FARAPULSE™ Cardiac Ablation System Plus in the Treatment of Persistent Atrial Fibrillation(PersAFOne II)
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: DEVICE: Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reliability of Measuring Walking-related Performance Fatigability Using Six Minute Walk Test in Persons With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis|Osteoarthritis, Knee
Interventions: DIAGNOSTIC_TEST: Six minute walk test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A 12-Week Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Pitavastatin|DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Elimination Diet Using a New Amino Acid Based Formula: Immunological and Clinical Effects in Cow's Milk Allergy
Status: TERMINATED
Conditions: Allergy|Food Allergy
Interventions: OTHER: Special Medical Food|OTHER: Special Medical Food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of a New Treatment for Symptoms of Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DRUG: UISH001|DRUG: matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-Centered Anticoagulation Self-Monitoring in Minority Patients
Status: COMPLETED
Conditions: Thromboembolism|Blood Coagulation Disorders|Cardiovascular Disease|Vascular Disease
Interventions: OTHER: Patient Self-Monitoring vs Anticoagulation Clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy
Status: RECRUITING
Conditions: Multiple System Atrophy (MSA)
Interventions: DRUG: ONO-2808|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole Augmentation of Antidepressants in PTSD
Status: COMPLETED
Conditions: PTSD
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4-AP Peripheral Nerve Crossover Trial
Status: NOT_YET_RECRUITING
Conditions: Peripheral Nerve Injury|Crush Injury
Interventions: DRUG: 4-Aminopyridine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: External Ionizing Radiation to Prevent Restenosis on Haemodialysis Vascular Access
Status: TERMINATED
Conditions: Renal Insufficiency, Chronic|Graft Occlusion, Vascular|Thrombosis|Intimal Hyperplasia
Interventions: DEVICE: External ionizing radiations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Urotensin-II and Soluble Epoxide Hydrolase Inhibitors on Skin Microvessel Tone in Patients With Heart Failure, and in Healthy Volunteers
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Urotensine II|DRUG: Soluble epoxide hydrolase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 3 Trial of Pamrevlumab or Placebo With Systemic Corticosteroids in Participants With Non-ambulatory Duchenne Muscular Dystrophy (DMD)
Status: TERMINATED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Pamrevlumab|DRUG: Placebo|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Aripiprazole IM Depot in Adult Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Mental Disorder|Nervous System Diseases
Interventions: DRUG: Aripiprazole, OPC-14597
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinic-based and Tele-monitored Home-based Intervention in Patients With Knee OA
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Clinical Based Isometric contraction strengthening Exercises using Thera band|OTHER: Telemonitored Home based Isometric Cntraction strengthening exercises using Thera band
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: REtinal Markers In Neuroinflammatory Diseases ("REMIND")
Status: RECRUITING
Conditions: Multiple Sclerosis|Neuroinflammatory Diseases
Interventions: DIAGNOSTIC_TEST: Optical coherence tomography (OCT)|DIAGNOSTIC_TEST: Static retinal vessel analyzer|DIAGNOSTIC_TEST: Dynamic retinal vessel analyzer|DIAGNOSTIC_TEST: Laser speckle flowgraphy system|OTHER: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Health Pathway for People With Persistent Symptoms Covid-19
Status: RECRUITING
Conditions: COVID-19
Interventions: OTHER: usual care and follow-up by a nurse|OTHER: Personalized Multifactorial Intervention (IMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel Metabolism
Status: COMPLETED
Conditions: Hypovitaminosis D|Insulin Resistance|Obesity|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Euro D and Ci-CalD|DIETARY_SUPPLEMENT: Euro D, Ci-CalD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)
Status: COMPLETED
Conditions: Hypophosphatasia
Interventions: DRUG: asfotase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety, Growth, Tolerance and Effects on the Intestinal Fora of a New Milk for Healthy Infants
Status: COMPLETED
Conditions: Growth
Interventions: DIETARY_SUPPLEMENT: Pétunia 1|DIETARY_SUPPLEMENT: Regular formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Phase 4, Open-label Study to Assess the Feasibility and Efficacy on Motor and Non-motor Symptoms of Switching From Pramipexole or Ropinirole to Rotigotine Transdermal Patch in Subjects With Advanced Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Advanced Idiopathic Parkinson's Disease
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2
Status: COMPLETED
Conditions: Electronic Cigarette Use|E-Cig Use|Cigarette Smoking|Cigarette Use, Electronic
Interventions: OTHER: E-cigarette e-liquid self-administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial of Erlotinib and Pemetrexed for Maintenance Treatment in Lung Adenocarcinoma
Status: UNKNOWN
Conditions: Lung Adenocarcinoma
Interventions: DRUG: Erlotinib, Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
Status: RECRUITING
Conditions: Gastrointestinal Tract Malignancies
Interventions: DRUG: Domvanalimab|DRUG: Quemliclustat|DRUG: Zimberelimab|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Serious Adverse Events Following Angiography
Status: COMPLETED
Conditions: Acute Renal Failure|Kidney Disease|Coronary Artery Disease
Interventions: DRUG: IV isotonic saline|DRUG: IV isotonic bicarbonate|DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION