pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Endoscopy Every 2 Years or Only as Needed in Monitoring Patients With Barrett Esophagus
Status: UNKNOWN
Conditions: Esophageal Cancer|Precancerous Condition
Interventions: PROCEDURE: 2 yearly endoscopy|PROCEDURE: comparison of screening methods|PROCEDURE: diagnostic endoscopic procedure|PROCEDURE: endoscopic biopsy|PROCEDURE: endoscopic procedure|PROCEDURE: quality-of-life assessment|PROCEDURE: screening method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Family Psychoeducation for Children With Mood Disorders
Status: COMPLETED
Conditions: Mood Disorders
Interventions: BEHAVIORAL: Multifamily Psychoeducation Group (MFPG)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recurrence and Bowel Function After Laparoscopic Vaginorectopexy, a Modified Anterior Rectopexy
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Prolapse|Fecal Incontinence|Defecation Disorder|Enterocele|Rectocele
Interventions: PROCEDURE: Laparoscopic vaginorectopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Membrane Sweeping Versus Transcervical Foley Catheter for Induction of Labour in Women With Previous Caesarean Delivery
Status: COMPLETED
Conditions: Labour, Induced|Vaginal Birth After Caesarean
Interventions: PROCEDURE: Membrane Sweeping versus Transcervical Foley Catheter for Induction of Labour in Women with Previous Caesarean Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl 12 Mcg Transdermal Patch For Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Fentanyl transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Preoperative Inspiratory Muscle Training for Patients With Peritoneal Metastases
Status: COMPLETED
Conditions: Peritoneal Metastases
Interventions: DEVICE: Inspiratory muscle training|DEVICE: Mini-PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of Favipiravir in Volunteers With Hepatic Impairment
Status: COMPLETED
Conditions: Healthy|Hepatic Impairment
Interventions: DRUG: Favipiravir|DRUG: Favipiravir|DRUG: Favipiravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PACCELIO - FDG-PET Based Small Volume Accelerated Immuno Chemoradiotherapy in Locally Advanced NSCLC
Status: RECRUITING
Conditions: Stage III Non-small Cell Lung Cancer|Locally Advanced|Unresectable
Interventions: RADIATION: standard Radiotherapy|DRUG: Chemotherapy|DRUG: Immunotherapy|RADIATION: Experimental Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Preoperative Correction of Anemia With Intravenously Iron in Colorectal Cancer Patients.
Status: UNKNOWN
Conditions: Colorectal Cancer|Anemia|Iron-deficiency
Interventions: DRUG: Iron(III)isomaltoside
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients
Status: COMPLETED
Conditions: Malignant Glioma|Glioblastoma Multiforme|Anaplastic Astrocytoma|Mixed Oligoastrocytoma|Malignant Astrocytoma
Interventions: DRUG: IL13-PE38QQR|PROCEDURE: targeted fusion protein therapy|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOSE Trial of Opioid Sparing Effect
Status: TERMINATED
Conditions: Dexmedetomidine|Mechanical Ventilation Complication|Critically Ill
Interventions: DRUG: Fentanyl|DRUG: Dexmedetomidine|DRUG: Dexmedetomidine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extracellular Volume Associated With New-Onset Atrial Fibrillation
Status: COMPLETED
Conditions: Cardiac Magnetic Resonance|Extracellular Volume Overload|Myocardial Infarction|Atrial Fibrillation
Interventions: OTHER: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD
Status: UNKNOWN
Conditions: Iron Deficiency Anemia|Inflammatory Bowel Disease
Interventions: DRUG: Captafer®|DRUG: Iron Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dolastatin 10 in Treating Patients With Metastatic Or Recurrent Liver, Bile Duct, or Gallbladder Cancer
Status: COMPLETED
Conditions: Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer
Interventions: DRUG: dolastatin 10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Changes In Bone Mineral Density (BMD), And Safety Of Rhbmp-2/CPM In Subjects With Decreased BMD
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: rhBMP-2/CPM injection and bisphosphonates, calcium, and vitamin D (oral bisphosphonate therapy)|DRUG: rhBMP-2/CPM injection and bisphosphonates, calcium, and vitamin D (oral bisphosphonate therapy)|DRUG: bisphosphonates, calcium, and vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Clinical Study of GB222 to Evaluate the Safety, Tolerability and PK Profiles.
Status: UNKNOWN
Conditions: Brain Tumor
Interventions: BIOLOGICAL: GB222 3mg/kg|BIOLOGICAL: GB222 5mg/kg|BIOLOGICAL: GB222 7.5mg/kg|BIOLOGICAL: GB222 10mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Ex Vivo Expanded Allogenic Universal Donor, TGFβi Natural Killer (NK) Cells With or Without Naxitamab (Danyelza) for the Treatment of Patients With Metastatic, GD2 Expressing, HER2 Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|HER2-Negative Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Gemcitabine|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Naxitamab|BIOLOGICAL: Universal Donor Expanded TGF-beta-imprinted NK Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Surgical Resection in Patients With Hepatic Oligometastatic Adenocarcinoma of the Pancreas
Status: RECRUITING
Conditions: Pancreatic Cancer|Metastasis|Surgery|Oligometastatic Disease
Interventions: DRUG: nal-irinotecan (nal-iri) (Onyvide), oxaliplatin (ox), 5-fluouracil (5-FU), folinic acid (FA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subarachnoid Hemorrhage Recovery And Galantamine
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage
Interventions: DRUG: Placebo|DRUG: 8mg galantamine twice daily|DRUG: 12mg galantamine twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Airway Clearance Technique of Oscillation and Lung Expansion in Bronchiectasis
Status: RECRUITING
Conditions: Bronchiectasis Adult
Interventions: DEVICE: Oscillation and Lung Expansion|BEHAVIORAL: Postural drainage|DRUG: Anti-infective therapy|DRUG: Mucolytic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Adaptogens in Patients With Long COVID-19
Status: COMPLETED
Conditions: Covid19
Interventions: DIETARY_SUPPLEMENT: ADAPT-232 oral solution|OTHER: Placebo oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of KHK7580 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: 1mg KHK7580|DRUG: 3mg KHK7580|DRUG: 6mg KHK7580|DRUG: 12mg KHK7580|DRUG: 6mg KHK7580 for 8days
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CYP2C9/CYP2C19 Polymorphism on Pharmacokinetics of Phenobarbital in Korean Neonatal Seizure Patients.
Status: COMPLETED
Conditions: Neonatal Seizure
Interventions: DRUG: Phenobarbital
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Methenamine in a Non-antibiotic, Multimodal Approach to UTI Prevention
Status: WITHDRAWN
Conditions: UTI|Female Urogenital Diseases|UTI - Lower Urinary Tract Infection
Interventions: DRUG: Methenamine Hippurate 1000 MG|DRUG: Vaginal estrogen|DIETARY_SUPPLEMENT: D-mannose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Sapablursen (Formerly ISIS 702843, IONIS-TMPRSS6-LRx) in Patients With Polycythemia Vera
Status: RECRUITING
Conditions: Phlebotomy Dependent Polycythemia Vera
Interventions: DRUG: sapablursen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: [F-18]PBR06|DRUG: [C-11]Methylreboxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase II Trial to Validate Markers for a Response Evaluation of a Combined Therapy in Patients With HER2+ Breast Cancer
Status: TERMINATED
Conditions: Carcinoma, Ductal, Breast
Interventions: PROCEDURE: Biopsy before and after three weeks of study treatment|DRUG: paclitaxel|DRUG: lapatinib|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjustment of Aminoglycoside Dosing Based on Peak Serum Concentration and Bacterial Minimal Inhibitory Concentration
Status: RECRUITING
Conditions: Aminoglycoside Dosing Based on PK/PD Characteristics
Interventions: DRUG: Aminoglycoside dose adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24-month Ticagrelor-based Dual-antiplatelet Therapy Versus Clopidogrel-based Dual-antiplatelet theRapy aftEr 12 Months of DrUg-eluting Stent Implantation in High isChEmic Risk Patients: P-REDUCE Trial
Status: NOT_YET_RECRUITING
Conditions: High Ischemic Risk
Interventions: DRUG: Ticagrelor-based dual-antiplatelet therapy|DRUG: Clopidogrel-based dual-antiplatelet therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Ara-c at 18 gm/m2 Versus 12 gm/m2 for 3 Cycles Each in AML Consolidation
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Ara-c|DRUG: Ara-c
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Exoskeleton ATLAS 2030 as Robot-assisted Physical Therapy to Children With Neuromuscular Diseases
Status: COMPLETED
Conditions: Cerebral Palsy|SMA II|Neuromuscular Diseases
Interventions: DEVICE: Exoskeleton rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
Status: SUSPENDED
Conditions: Alzheimers Disease|Dementia|Alzheimers Disease, Familial
Interventions: DRUG: Gantenerumab|DRUG: Matching Placebo (Gantenerumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bimatoprost Ophthalmic Solution in Increasing Eyebrow and Eyelash Growth in Patients Who Have Undergone Chemotherapy for Breast Cancer and in Healthy Participants
Status: WITHDRAWN
Conditions: Alopecia|Breast Cancer
Interventions: DRUG: bimatoprost ophthalmic solution|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of Vitamin K2 Supplementation on the Progression of Coronary Artery Calcification
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Menaquinone-7 (Vitamin K2)|OTHER: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of a Prothetic Absorbable Mesh in Incisional Hernia Prevention After Midline Laparotomy
Status: UNKNOWN
Conditions: Incisional Hernia
Interventions: PROCEDURE: Reinforcement with Absorbable Mesh|RADIATION: Control CT|OTHER: Clinical Follow Up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Validation of Respiratory Epithelial Functional Assessment to Predict Clinical Efficacy of Orkambi®.
Status: COMPLETED
Conditions: Cystic Fibrosis|Homozygous F508del Mutation
Interventions: DIAGNOSTIC_TEST: Nasal brushing|OTHER: Sputum sample|OTHER: blood sample|DRUG: Orkambi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pain Management and Behavioral Outcomes in Patients With Dementia
Status: COMPLETED
Conditions: Dementia|Alzheimer Disease, Pain|Behavior, Agitation
Interventions: DRUG: acetaminophen 650 mg qid and placebo qid PRN. The other arm was placebo qid and acetaminophen 650 mg qid PRN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study for Treatment of Cancer in Children With Ataxia-telangiectasia
Status: COMPLETED
Conditions: Ataxia-Telangiectasia
Interventions: DRUG: vinblastine, vincristine, prednisone, daunorubicin|DRUG: doxorubicin, methotrexate, cyclophosphamide, L-asparaginase|DRUG: etoposide, cytarabine, mercaptopurine|DRUG: dexamethasone, procarbazine|PROCEDURE: chemotherapy, intrathecal chemotherapy, steroid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial on Innovative Technologies in Colonoscopy
Status: COMPLETED
Conditions: Polyps|Neoplasms|Inflammatory Bowel Disease
Interventions: DEVICE: Innovative colonoscopy (Olympus CF-HQ190F, NBI + Dual Focus)|DEVICE: Conventional colonoscopy (Olympus CF-H180DL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ultrasound-Guided Obturator Nerve Block for Ambulatory Hip Arthroscopy
Status: UNKNOWN
Conditions: Pain
Interventions: PROCEDURE: Obturator Nerve Block|DRUG: Ropivacaine|DRUG: Placebo Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-transplantation Benadamustine and Cyclophosphamide in Patients With Refractory Myeloid Malignancies
Status: RECRUITING
Conditions: Myeloid Leukemia, Acute|Chronic Myeloid Leukemia|Myelodysplastic Syndromes|Myeloproliferative Neoplasm
Interventions: DRUG: Bendamustine Hydrochloride|DRUG: Cyclophosphamid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medication Abortion Via Pharmacy Dispensing
Status: COMPLETED
Conditions: Pregnancy Related|Abortion Early
Interventions: DRUG: Mifepristone|OTHER: Training on mifepristone dispensing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: High Flow Nasal Oxygen During Sedation
Status: COMPLETED
Conditions: Anesthesia|Cardiac Disease
Interventions: DEVICE: High flow nasal oxygen|DEVICE: Standard oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Effects of Interleukin-12 (rhIL-12) in HIV-Positive Patients With CD4 Cell Counts Less Than 50 Cells/mm3 or 300-500 Cells/mm3
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Interleukin-12
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vitamin A Replacement in Patients Undergoing HSCT and Its Role on MBI-LCBI Rates
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplant
Interventions: DIETARY_SUPPLEMENT: Vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Venetoclax|DRUG: Rovalpituzumab Tesirine|DRUG: ABBV-181
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Substrate Mapping (DSM) for Ischemic VT
Status: TERMINATED
Conditions: Ischemic Ventricular Tachycardia
Interventions: DEVICE: Dynamic Substrate Mapping-guided ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Status: WITHDRAWN
Conditions: Traumatic Brain Injury|Subdural Hematoma|Cerebral Contusion|Head Injury|Cerebral Edema
Interventions: DRUG: Induced, sustained hypernatremia using hypertonic saline|DRUG: Standard of care (hypertonic saline and mannitol; serum sodium)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose-Derived Adult Stem Cell Implantation for Corneal Diseases (ADASCs-CT-CD)
Status: COMPLETED
Conditions: Ophthalmological Disorder|Corneal Dystrophy|Treatment|Therapy|Keratoconus
Interventions: PROCEDURE: Implantation|PROCEDURE: Lipoaspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of 3 Dose Regimens of BioChaperone to Becaplermin Gel for the Treatment of Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: DRUG: Biochaperone PDGF-BB Low dose|DRUG: Biochaperone PDGF-BB High dose|DRUG: Regranex|DRUG: Biochaperone PDGF-BB Very Low Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries
Status: COMPLETED
Conditions: Agitation, Emergence
Interventions: DRUG: "Ketamine" and "dexmedetomidine" and "propofol" and "0.9%saline"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Capecitabine,Oxaliplatin & Erbitux Given Throughout Multi-Modal Therapy for Locally Advanced Rectal Adenocarcinoma
Status: TERMINATED
Conditions: Rectal Cancer
Interventions: DRUG: Capecitabine, Oxaliplatin and Cetuximab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRA and ARB Treatment in Screening of Primary Aldosteronism
Status: COMPLETED
Conditions: Primary Aldosteronism Due to Aldosterone Producing Adenoma
Interventions: DRUG: canrenone 50-100 mg orally once a day|DRUG: olmesartan 10-20 mg orally once a day
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of SHR-1314 by Subcutaneous Injection in Active Moderate to Severe Graves' Orbitopathy Patients
Status: UNKNOWN
Conditions: Active Moderate to Severe Graves' Orbitopathy
Interventions: DRUG: SHR-1314
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache
Status: COMPLETED
Conditions: Postdural Puncture Headache
Interventions: DRUG: Cosyntropin|PROCEDURE: Epidural Blood Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microperimetry and Eye Progressing From Stage 3 to Stage 4 Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Stage 3 Age Related Macular Degeneration (AREDS Classification)
Interventions: DEVICE: MAIA™ (Centervue, Padova, Italy; distributed in France by EDC Lamy, Carvin, France)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Azacitidine|DRUG: Decitabine|DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Etoposide|COMBINATION_PRODUCT: ITMHA|DRUG: Idarubicin|DRUG: Fludarabine|DRUG: Mitoxantrone|DRUG: Erwinia asparaginase|DRUG: Sorafenib|DRUG: G-CSF|DRUG: Dexrazoxane|BIOLOGICAL: Stem Cell Transplant|DRUG: Asparaginase Erwinia Chrysanthemi, Recombinant-Rywn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupoint Transcutaneous Electrical Nerve Stimulation in Hospitalized COPD Patients With Severe Dyspnoea
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DEVICE: AcuTENS|DEVICE: Sham AcuTENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Cook Zilver PTX Drug-eluting Stent Versus Bypass Surgery for the Treatment The Cook Zilver PTX Drug-eluting Stent Versus Bypass Surgery of Femoropopliteal TASC C&D Lesions
Status: UNKNOWN
Conditions: Peripheral Vascular Disease
Interventions: DEVICE: Zilver PTX|DEVICE: prosthetic bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PSMA-PET CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer
Status: COMPLETED
Conditions: Peritoneal Neoplasms|Retroperitoneal Neoplasms|Gastrointestinal Neoplasms|Adenocarcinoma|Neuroblastoma|Ovarian Neoplasms|Sarcoma|Adrenocortical Carcinoma|Wilms Tumor|Rhabdomyosarcoma|Desmoplastic Small Round Cell Tumor
Interventions: DRUG: CHPP of Cisplatin|PROCEDURE: Abdominal Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine in Combination With Low Dose Intensity Venetoclax in Patients With AML Incl. Explorative AML Profiling
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of Withdrawal
Status: SUSPENDED
Conditions: Opioid Withdrawal (Disorder)
Interventions: DRUG: Lofexidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Piperacillin/Tazobactam in Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Neutropenia|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Piperacillin|DRUG: Piperacillin-tazobactam combination product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: T-Cell Responses to Neoantigens Post Treatment With Ipilimumab in Men With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs
Status: NOT_YET_RECRUITING
Conditions: Stage III Breast Cancer|Stage IV Breast Cancer|Stage III Lung Cancer|Stage IV Lung Cancer|AML|Multiple Myeloma in Relapse|Carcinoma|Carcinoma, Pancreatic|Carcinoma of Lung|Carcinoma, Non-Small-Cell Lung|Carcinoma Breast|Carcinoma Prostate|Carcinoma, Hepatocellular|Carcinoma, Renal Cell|Carcinoma, Neuroendocrine|Carcinoma, Small Cell Lung|Carcinoma, Ovarian|Carcinoma Bladder|Carcinoma of Esophagus|Carcinoma Cervix|Carcinoma, Thymic|Carcinoma, Ductal|Carcinoma of the Head and Neck|Carcinoma of the Lip|Carcinoma of the Oral Cavity|Carcinoma of Unknown Primary|Carcinoma of the Skin|Carcinoma of the Anus|Carcinoma of the Larynx|Carcinoma of the Penis|Carcinoma of the Oropharynx|Carcinoma of the Appendix|Carcinoma of the Paranasal Sinus|Carcinoma of the Vulva|Malignant Pleural Effusion|Malignant Ascites|Mesothelioma|Cholangiocarcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Loteprednol for Contact Lens Intolerance and Dryness
Status: UNKNOWN
Conditions: Contact Lenses Dryness
Interventions: DRUG: Loteprednol|OTHER: Rewetter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-center, Self-controlled, Prospective Case Series Pilot Study to Assess the Effect of Lamivudine (3TC) on Neurocognitive Impairment Biomarkers and Type-I IFN (Interferon)-Stimulated Genes in the Plasma of Patients With Mild Cognitive Impairment (MCI)
Status: NOT_YET_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Lamivudine 300 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypovitaminosis D in Neurocritical Patients
Status: COMPLETED
Conditions: Craniocerebral Trauma|Intracranial Aneurysm|Brain Neoplasms|Spinal Cord Injuries|Seizures|Meningitis|Stroke|Intracranial Hemorrhages|Critical Illness|Vitamin d Deficiency
Interventions: DRUG: Cholecalciferol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Assessing Treatment of Patients Ages 10-17 With Bipolar Depression
Status: COMPLETED
Conditions: Bipolar Depression
Interventions: DRUG: Olanzapine Fluoxetine Combination (OFC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Activity and Cell Kinetics of CYAD-211 in Patients With Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapse/Refractory Multiple Myeloma
Interventions: BIOLOGICAL: CYAD-211|DRUG: Endoxan|DRUG: Fludara
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can the Use of Uricap Female Device Lead to Better Care for Women > 75+Years?
Status: WITHDRAWN
Conditions: Urinary Incontinence|Urinary Tract Infections|Incontinence-associated Dermatitis|Cognition Disorders in Old Age|Behavioral and Psychiatric Symptoms of Dementia
Interventions: DEVICE: Use of Uricap Female, a New Urine Collecting Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quinidine Versus Verapamil in Short-coupled Idiopathic Ventricular Fibrillation
Status: ENROLLING_BY_INVITATION
Conditions: Short-coupled Idiopathic Ventricular Fibrillation
Interventions: DRUG: Quinidine|DRUG: Verapamil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BP1001-A in Patients With Advanced or Recurrent Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|Carcinoma, Ovarian Epithelial|Fallopian Tube Neoplasms|Endometrial Cancer|Peritoneal Cancer|Solid Tumor
Interventions: DRUG: BP1001-A (Liposomal Grb2 Antisense Oligonucleotide)|DRUG: BP1001-A (Liposomal Grb2 Antisense Oligonucleotide) with paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging 5HT7 Antagonist Effects in Bipolar Disorder
Status: UNKNOWN
Conditions: Bipolar Disorder
Interventions: DRUG: JNJ-18038683|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerous Inherited Disorders
Status: TERMINATED
Conditions: Immunodeficiency Syndrome|Severe Aplastic Anemia|Genetic Disorder
Interventions: PROCEDURE: Allogeneic Bone Marrow Transplantation|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|PROCEDURE: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Sirolimus|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improve Glaucoma Medication Adherence
Status: COMPLETED
Conditions: Glaucoma
Interventions: BEHAVIORAL: Educational - glaucoma|BEHAVIORAL: Dose monitoring and reminder|BEHAVIORAL: Educational - general|BEHAVIORAL: Dose monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Determine the Excretion Balance and Pharmacokinetics of 14C-GSK573719
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Treatment Period 1 - IV dose of GSK573719|DRUG: Treatment Period 2 - Oral dose of GSK573719
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concentration-controlled Therapy of Mycophenolate Mofetil (MMF) in Proliferative Lupus Nephritis
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Candonilimab Plus Bevacizumab for Patients With Advanced HCC Who Progressed on A+T
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Candonilimab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2b Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study, Evaluating Efficacy and Safety of Allocetra-OTS in Patients With Severe or Critical COVID-19 With Associated Acute Respiratory Distress Syndrome (ARDS)
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: ALLOCETRA-OTS|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tislelizumab in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Gastric, or Gastroesophageal Junction Carcinoma
Status: COMPLETED
Conditions: Gastric, or Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Tislelizumab|DRUG: Placebo|DRUG: Cisplatin|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Plus Montanide ISA-51 and Sargramostim in Treating Patients With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: sargramostim|BIOLOGICAL: telomerase: 540-548 peptide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: First in Human Study to Determine the Safety, Tolerability and Preliminary Efficacy of an Anti-CXCR4 Antibody in Subjects With Acute Myelogenous Leukemia and Selected B-cell Cancers
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Diffuse Large B-Cell Leukemia|Chronic Lymphocytic Leukemia|Follicular Lymphoma
Interventions: DRUG: BMS-936564 (Anti-CXCR4)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis
Status: UNKNOWN
Conditions: Optic Neuritis
Interventions: DEVICE: Corticosteroid & Plasma exchange|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D-Printed CPAP Masks for Children With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Craniofacial Abnormalities|Pediatric Disorder
Interventions: DEVICE: Personalized continuous positive airway pressure (CPAP) mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Therapy With Paclitaxel, Carboplatin and Megesterol Acetate for the Management of Uterine Cancer
Status: COMPLETED
Conditions: Uterine Cancer
Interventions: DRUG: Paclitaxel ,Carboplatin , Megesterol Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet.
Status: COMPLETED
Conditions: Primary Hyperparathyroidism|Parathyroid Adenoma|Parathyroid Hyperplasia
Interventions: DRUG: Cinacalcet 30 mg Tablet|DRUG: Denosumab Inj 60 mg/ml|OTHER: Placebo tablets|OTHER: Saline Injection (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reproducibility of Tearfilm Osmolarity Measurements Using TearLab® in Patients With Dry Eye Syndrome and Healthy Subjects
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DEVICE: Measurement of tear film osmolarity with the TearLab® instrument|OTHER: Schirmer I test|OTHER: Tear break up time|DEVICE: Optical Quality Analysis System|OTHER: Ocular Surface Disease Index
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Chitosan Brushes vs Air-Abrasive Devices on Peri-implant Mucositis Treatment: A Randomized Clinical
Status: RECRUITING
Conditions: Peri-implant Mucositis|Peri-Implantitis|Bleeding on Probing|Periodontal Pocket
Interventions: PROCEDURE: Labrida BioClean|PROCEDURE: EMS Handy 3.0 Perio Premium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of CBT in Improving Psycho-Neuro-Endocrine Factors in Women Following In Vitro Fertilization Program
Status: RECRUITING
Conditions: Cognitive Behavioral Therapy|Hormone Disturbance|In Vitro Fertilization
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Recovery of Laboratory, Clinical, and Community-Based Measures of Head and Trunk Control in People With Acquired Vestibulopathy
Status: UNKNOWN
Conditions: Vestibular Schwannoma|Vestibular Disorder
Interventions: BEHAVIORAL: Gaze and Postural Retraining Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Respiratory Drugs When Used In Combination And Separately From A Novel Inhaler Device In Healthy Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW685698X & GW642444M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Akt Inhibitor MK2206 in Treating Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: Recurrent Breast Carcinoma|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: Akt Inhibitor MK2206|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health Application for Adolescents With Asthma
Status: COMPLETED
Conditions: Adolescent|Nursing Care|Asthma in Children|Self Efficacy
Interventions: OTHER: Mobile Health Application|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Omega-3 Fatty Acids Supplement in Cognition of Young Healthy Adults and in Their Reaction Time of Computerized Test After 3 Months of Taking High-concentrated DHA and EPA Fish Softgels
Status: UNKNOWN
Conditions: Cognition|Brain|Neuroscience
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid|DIETARY_SUPPLEMENT: Eicosapentaenoic acid|DIETARY_SUPPLEMENT: Olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: COLLIGO-HCM: A Multinational Observational Study of the Real-World Effectiveness of Mavacamten Among Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertrophic Cardiomyopathy (HCM)
Interventions: DRUG: Approved Hypertrophic Cardiomyopathy drug treatments|DRUG: Mavacamten
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) Self-Referential Processing (rTMS-SRP)
Status: WITHDRAWN
Conditions: Schizophrenia|Schizo Affective Disorder
Interventions: DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Novel Sound Changing Principles in Hearing Instruments to Determine Their Application - 2020_09
Status: COMPLETED
Conditions: Hearing Loss
Interventions: DEVICE: Hearing Aid without NR enabled|DEVICE: Hearing Aid with NR(1)|DEVICE: Hearing Aid with NR(2)|DEVICE: Hearing Aid with NR(3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biochemotherapy and Bevacizumab Followed by Consolidation Therapy With Ipilimumab for Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Biochemo + bevacizumab then ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: active tVNS|DEVICE: sham tVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optically Pumped 4He Magnetometers Performances Compared With Medical Reference Methods (ECG and MEG)
Status: TERMINATED
Conditions: Healthy
Interventions: DEVICE: MINIMAG / MEG|DEVICE: MINIMAG / ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Posttraumatic Stress Disorder (PTSD) With Early Hydrocortisone Treatment: Pilot
Status: UNKNOWN
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Hydrocortisone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS Patients
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia, Adult|Myelodysplastic Syndromes, Adult
Interventions: DRUG: Hydroxyurea, Hydroxycarbamide|DRUG: Valproic acid|DRUG: 6-Mercaptopurine (6-MP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture for Postoperative Ileus After Laparoscopic Surgery for Mid and Low Rectal Cancer
Status: UNKNOWN
Conditions: Postoperative Ileus|Rectal Cancer
Interventions: PROCEDURE: Electroacupuncture|PROCEDURE: Sham Acupuncture|DEVICE: Electroacupuncture|DEVICE: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatic Venous Pressure Gradient and Elastography in Porto-sinusoidal Vascular Disorder
Status: NOT_YET_RECRUITING
Conditions: Portal Hypertension|Non-Cirrhotic Portal Hypertension|Non-Cirrhotic Portal Fibrosis|Regenerative Nodular Hyperplasia|Incomplete Septal Cirrhosis|Obliterative Portal Venopathy|Idiopathic Non-Cirrhotic Portal Hypertension|Hepatoportal Sclerosis|Idiopathic Portal Hypertension|Vascular Disorder of Liver
Interventions: PROCEDURE: Hepatic vein pressure gradient measurement|PROCEDURE: Ultrasound-guided percutaneous liver biopsy|DIAGNOSTIC_TEST: Multiparametric Abdominal Magnetic Resonance with Elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Massage Therapy and Tissue Flossing Technique
Status: RECRUITING
Conditions: Spastic Diplegia Cerebral Palsy
Interventions: OTHER: Transverese friction massage and tissue floss technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study to Compare the Dosing of Valproic Acid in Subjects With Different Body Weights
Status: TERMINATED
Conditions: Healthy|Obesity|Pharmacokinetics
Interventions: DRUG: Valproic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Experimental Analysis of HIV Risk Assessment Reactivity in South African Clinics
Status: COMPLETED
Conditions: HIV Prevention and Assessment Reactivity
Interventions: BEHAVIORAL: Detailed baseline interview, enhanced HIV intervention|BEHAVIORAL: General baseline interview, enhanced HIV intervention|BEHAVIORAL: No baseline interview, enhanced HIV intervention|BEHAVIORAL: Detailed baseline interview, standard of care intervention|BEHAVIORAL: General baseline interview, standard of care intervention|BEHAVIORAL: No baseline interview, standard of care intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Randomized Study to Evaluate a Novel Method of Specific Allergen Immunotherapy
Status: COMPLETED
Conditions: Rhinoconjunctivitis Due to Grass Pollen Allergy
Interventions: BIOLOGICAL: Allergen specific immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of DEcolonization in Patients With HAematological Malignancies (DEHAM)
Status: COMPLETED
Conditions: Hematological Infection
Interventions: DRUG: Colistimethate Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION