pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: T1-T2 Breast Cancer: Comparison Between Removal and Preservation of Axillary Lymph Nodes (SINODAR ONE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Removal of axillary lymph nodes.|PROCEDURE: Preservation of axillary lymph nodes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of a Reusable Silicone Hydrogel Multifocal Contact Lens
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: JJV Investigational Multifocal Contact Lens|DEVICE: 1-Day Acuvue® Moist Brand Multifocal Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Very-Low Nicotine Cigarettes and Non-Daily Smokers
Status: COMPLETED
Conditions: Smoking
Interventions: DRUG: Very low nicotine content cigarettes|DRUG: Normal nicotine content cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study Switching Individuals Receiving EFV With Continuing Central Nervous System Toxicity to TMC125
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Etravirine|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation Program and Detraining in Patients With Post-COVID-19 Sequelae
Status: COMPLETED
Conditions: COVID-19 Acute Respiratory Distress Syndrome
Interventions: OTHER: Telerehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Status: ACTIVE_NOT_RECRUITING
Conditions: Methamphetamine Abuse|Opioid-use Disorder|HIV Seropositivity
Interventions: BEHAVIORAL: High intensity contingency management|BEHAVIORAL: Low intensity contingency management|BEHAVIORAL: SMS reminders|BEHAVIORAL: Matrix only|BEHAVIORAL: Matrix + Contingency management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DKF-306 in Patients With Periodontal Diseases
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: DRUG: DKF-306|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chidamide in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma (R/R PTCL)
Status: RECRUITING
Conditions: Relapsed or Refractory Peripheral T-cell Lymphoma
Interventions: DRUG: Chidamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fractional Microneedle Radiofrequency and Fractional Erbium-Doped Glass 1,565-nm for Baggy Lower Eyelids
Status: UNKNOWN
Conditions: Photoaging
Interventions: PROCEDURE: Treatment one side BLE by NAFL|PROCEDURE: Treatment another side BLE by FMR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of Zirconium Silicate in Chronic Kidney Disease or Moderate Kidney Dysfunction With Mild Hyperkalemia
Status: COMPLETED
Conditions: Hyperkalemia|Chronic Kidney Disease|Kidney Dysfunction
Interventions: DRUG: Zirconium silicate (ZS)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of BATon BP and Sympathetic Function in Resistant Hypertension (The Nordic BAT Study)
Status: COMPLETED
Conditions: Resistant Hypertension
Interventions: DEVICE: BAT|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ANC1 Study Impact of a Geriatric and Nutritional Evaluation for the Malnutrition and Malnutrition Risk Screening in Patients Over 70 Years With Colorectal Surgery.
Status: UNKNOWN
Conditions: Colorectal Tumor
Interventions: PROCEDURE: Malnutrition screening and perioperative nutritional support
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evolutionary Nutrition Pilot: Enhancing Fetal Growth and Brain Development
Status: UNKNOWN
Conditions: Growth Disorders|Malnutrition, Fetal|Stunting|Development; Delayed, Malnutrition|Nutrition Disorder, Fetal|Maternal Nutritional Disorders Affecting Fetus or Newborn
Interventions: OTHER: Evolutionary Nutrition Package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exparel and Marcaine for Pain Management in Thoracoscopic Lobectomy Patients
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Lung Cancer Stage 1
Interventions: DRUG: Liposomal Bupivacaine|DRUG: Bupivacaine-Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using SWE and MFI
Status: RECRUITING
Conditions: Lower Extremity Musculoskeletal Injury
Interventions: DEVICE: Shear wave elastography and microvascular flow imaging.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baxdrostat Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Japanese Population
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: baxdrostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FIBrinogen REplenishment in Surgery
Status: COMPLETED
Conditions: Deficiency; Fibrinogen, Acquired
Interventions: DRUG: Octafibrin|DRUG: Cryoprecipitate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combing a Deep Learning-Based Radiomics With Liquid Biopsy for Preoperative and Non-invasive Diagnosis of Glioma
Status: UNKNOWN
Conditions: Glioma (Diagnosis)|Liquid Biopsy|Deep Learning
Interventions: DIAGNOSTIC_TEST: Prediction of glioma grading and molecular subtype
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Noninvasive Modulation of Chronic Neuropathic Pain
Status: RECRUITING
Conditions: Neuropathic Pain|Chronic Pain
Interventions: DEVICE: Active stimulation using low-frequency ultrasonic transducer|DEVICE: Sham stimulation using low-frequency ultrasonic transducer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Radiofrequency Ablation of Genicular Nerves on Postural Stability in Patients With Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cool Baby Oil for Pruritus and Sleep Quality Among Uremic Patients
Status: COMPLETED
Conditions: Haemodialysis-Associated Pruritus
Interventions: OTHER: Baby oil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antibody Persistence & Immune Memory in Healthy Adults Previously Vaccinated With Twinrix Adult
Status: COMPLETED
Conditions: Hepatitis A|Hepatitis B
Interventions: PROCEDURE: Blood sampling|BIOLOGICAL: Engerix-B|BIOLOGICAL: Havrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pneumostasis With Use of Bio-absorbable Mesh and Fibrin Sealant in Lung Resection
Status: WITHDRAWN
Conditions: Air Leak From Lung
Interventions: DEVICE: Polyglycolic acid felt|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Magnetic Therapy and Cervical Stabilization Exercises in Cervical Spondylosis
Status: NOT_YET_RECRUITING
Conditions: Cervical Spondylosis
Interventions: DEVICE: low Frequency High Intensity magnetic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Letrozole and Clomifene Citrate
Status: UNKNOWN
Conditions: Polycystic Ovarian Syndrome|Subfertility
Interventions: DRUG: Letrozole|DRUG: Clomiphene
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palbociclib and INCMGA00012 in People With Advanced Liposarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Well-differentiated/Dedifferentiated Liposarcoma
Interventions: DRUG: INCMGA00012|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Test AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) in Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)
Status: RECRUITING
Conditions: Recurrent T Acute Lymphoblastic Leukemia|Refractory T Acute Lymphoblastic Leukemia
Interventions: DRUG: AKR1C3-activated Prodrug OBI-3424
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Light Therapy in Modulating the Clinical Phenotype of Patients With Primary and Comorbid Chronic Insomnia.
Status: RECRUITING
Conditions: Insomnia Chronic
Interventions: OTHER: Luminette|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Olmesartan Medoxomil (CS-866) in Patients With Chronic Glomerulonephritis or Diabetic Nephropathy
Status: COMPLETED
Conditions: Chronic Glomerulonephritis|Diabetic Nephropathy
Interventions: DRUG: olmesartan medoxomil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: RNA analysis|GENETIC: nucleic acid sequencing|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: This is a Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of AZD9742 After Single IV Doses in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD9742|DRUG: Placebo to match AZD9742
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improvement of Quality of Life in Patients Using Low-dose Pills in the Different Phases of Menacme
Status: COMPLETED
Conditions: Quality of Life|Menopause|Contraception
Interventions: DRUG: gestoden 60 mcg|DRUG: ethinylestradiol 15 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy of a Sport Drink After High-intensity Aerobic Exercise
Status: COMPLETED
Conditions: Hydration|Blood Glucose|Sport Recovery|Microbiota
Interventions: DIETARY_SUPPLEMENT: Hydration drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Success and Survival Rate of Tranmucosal Versus Bone Level Implants: Randomized Clinical Trial
Status: RECRUITING
Conditions: Bone Loss
Interventions: OTHER: Prime taper implant + cover screw|OTHER: Prime taper implant + healing screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Versus Local Corticosteroid Injection for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Shock Wave
Interventions: DEVICE: Extracorporeal shock wave
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Quadratus Lumborum Block and Erector Spina Plane Block in Nephrectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Postoperative Complications
Interventions: PROCEDURE: Erector Spina Plane Block|PROCEDURE: Quadratus Lumborum Block 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With and Without Renal Impairment
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Dabigatran etexilate high dose|DRUG: Dabigatran etexilate low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Effectiveness of IV vs Oral Acetaminophen Given Perioperatively for Lap Choles for Pain Control,
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy
Interventions: DRUG: 2 capsules Oral Tylenol 2000 mg and IV "salt water"|DRUG: IV tylenol 1000mg and 2 oral capsule "sugar pills"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics and Pharmacodynamics of Biphasic Insulin Aspart 30 and 50 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae vs Fascia Iliaca Block in Hip Arthroplasty
Status: WITHDRAWN
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Single-shot erector spinae plane block|PROCEDURE: Single-shot fascia iliaca block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Activity of 90Y-Labeled IDEC-159 in Subjects With Metastatic Colorectal Adenocarcinoma
Status: TERMINATED
Conditions: Colorectal Cancer|Metastases
Interventions: DRUG: Unconjugated IDEC-159|DRUG: 111In-IDEC-159|DRUG: 90Y-IDEC-159
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treosulfan-TMI Conditioning and Rapamycin GvHD Prophylaxis Before Allo-HSCT
Status: TERMINATED
Conditions: Irradiated Bone Marrow|Transplant-Related Hematologic Malignancy|Leukemia, Acute|Multiple Myeloma|Graft Vs Host Disease
Interventions: DRUG: Conditioning treatment "Treosulfan-TMI"|PROCEDURE: SCT|DRUG: GvHD prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observe Intestinal Tract Cleaness of Senile Constipation Patients Used Gastrointestinal External Stimulation
Status: RECRUITING
Conditions: Electric Stimulation
Interventions: DEVICE: gastrointestinal external stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis
Status: COMPLETED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: EDP-305 1 mg|DRUG: EDP-305 2.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Insulin Resistance on the Safety and Efficacy of Pegylated Interferon and Ribavirin Treatment in HCV (Study P05562)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C Virus
Interventions: BIOLOGICAL: Pegylated Interferon|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cost-utility Analysis of Maintenance rTMS for Treatment-resistant Depression
Status: UNKNOWN
Conditions: Treatment-resistant Depression
Interventions: DEVICE: Systematic maintenance rTMS|DEVICE: rTMS course in case of relapse|DEVICE: sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Toddler Biomarker of Nutrition Study
Status: NOT_YET_RECRUITING
Conditions: Pediatric Nutrition|Nutrition, Healthy
Interventions: OTHER: Applesauce Pouch|OTHER: Fruit-vegetable puree blend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: NaliCap (Irinotecan Liposome (Nal-IRI)/Capecitabine) vs. NAPOLI (Nal-IRI/5-FU/LV) ) in Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Irinotecan Liposomal Injection [Onivyde]|DRUG: Capecitabine|DRUG: 5-fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib Trial of Two Folate Binding Protein Peptide Vaccines (E39 and J65) in Breast and Ovarian Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer
Interventions: BIOLOGICAL: E39 peptide vaccine|BIOLOGICAL: E39 vaccine then J65 vaccine|BIOLOGICAL: J65 vaccine then E39 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Fenugreek Wraps in Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Fenugreek wrap|DRUG: Diclofenac Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Inhibition of Ovulation of Two Oral Estrogen/Progestogen Regimens in Healthy, Young Females Over a Period of 3 Treatment Cycles
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: BAY86-4891 (Estradiol / Drospirenone)|DRUG: BAY86-4891 (Estradiol / Drospirenone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Grazoprevir/Elbasvir for Genotype 1b Chronic Hepatitis C After Liver or Kidney Transplantation
Status: TERMINATED
Conditions: Chronic Hepatitis c|Liver Transplant Infection|Kidney Transplant Infection
Interventions: DRUG: grazoprevir 100 mg/ elbasvir 50 mg, Zepatier®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Adjuvant Radiotherapy Combined With Chemotherapy for Patients With High-risk Endometrial Cancer
Status: COMPLETED
Conditions: Prosthesis Survival
Interventions: RADIATION: radiotherapy|DRUG: Cisplatin|DRUG: Cisplatin and Doxorubicin and Cyclophosphamide|DRUG: Paclitaxel and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy
Status: COMPLETED
Conditions: Anemia|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: darbepoetin alfa|DRUG: epoetin alfa|PROCEDURE: fatigue assessment and management|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the C5a/C5aR1 Axis in IgG4-associated Disease: a Potential Therapeutic Target
Status: NOT_YET_RECRUITING
Conditions: Immunoglobulin G4-Related Disease
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Moran AMD Genetic Testing Assessment Study
Status: COMPLETED
Conditions: Age-Related Macular Degeneration|Genetic Testing|Nutritional Biomarkers
Interventions: BEHAVIORAL: Early disclosure of genetic testing results|BEHAVIORAL: Late disclosure of genetic testing results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of an Amniotic Fluid Derived Allograft, (FlōGraft®) in Rotator Cuff Repairs: A Prospective Study
Status: UNKNOWN
Conditions: Rotator Cuff Tear|Fatty Atrophy
Interventions: BIOLOGICAL: Superiority of augmented repairs|BIOLOGICAL: Fat degeneration of supraspinatus muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: WT1 TCR Gene Therapy for Leukaemia: A Phase I/II Safety and Toxicity Study
Status: COMPLETED
Conditions: Acute Myeloid Leukaemia|Chronic Myeloid Leukaemia
Interventions: GENETIC: WT1 TCR-transduced T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Pharmacokinetic, Pharmacodynamic and Safety of CHF 1535 (Fixed Combination of Beclomethasone + Formoterol) Administered Via the NEXT DPI, Versus the Free Combination of Licenced Beclomethasone DPI and Formoterol DPI in Asthmatic Adolescent and Adult Patients.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF1535 NEXT DPI|DRUG: BDP DPI and formoterol DPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Best Approach to Care Compared to Diversified Chiropractic Adjustive Technique
Status: COMPLETED
Conditions: Low Back Pain|Headache|Shoulder Pain
Interventions: PROCEDURE: spinal manipulation & patient education/nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Somatropin in Children With Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Disorder|Growth Hormone Deficiency in Children
Interventions: DRUG: somatropin|DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Tricuspid Valve Insufficiency
Interventions: DEVICE: TRAIPTA (Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadruple Versus Sequential Therapy for Helicobacter Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Sequential therapy|DRUG: Quadruple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Papilloma Virus Vaccine Safety and Immunogenicity Trial in Young Adolescent Women With GSK Bio HPV-16/18.
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: HPV-16/18 L1/AS04
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation
Status: UNKNOWN
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active rTMS-DLPFC|DEVICE: Active iTBS-DLPFC|DEVICE: Sham TBS-DLPFC or Sham rTMS-DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Water Exchange (WE) vs. WE Plus Cap-assisted Colonoscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Colonoscopy|Real-time Maximum Insertion Pain
Interventions: DEVICE: cap|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Micronized Progesterone Versus Norethisterone Acetate in Combination With Estrogen as Menopausal Hormone Therapy
Status: RECRUITING
Conditions: Menopausal Symptoms
Interventions: DRUG: Micronized progesterone in continuous combination with oral estrogen|DRUG: Norethisterone acetate in continuous combination with oral estrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT Treatment Versus Non Treatment of Low-risk BCCs in Elderly
Status: RECRUITING
Conditions: Basal Cell Carcinoma|Elderly
Interventions: OTHER: Standard of care|OTHER: Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2 Dose-finding Study of TAK-272 in Participants With Type 2 Diabetes Mellitus and Microalbuminuria
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus and Microalbuminuria
Interventions: DRUG: TAK-272|DRUG: TAK-272 Placebo|DRUG: Candesartan cilexetil|DRUG: Candesartan cilexetil Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Workplace Wellness: Improving Your Experience at Work
Status: COMPLETED
Conditions: Sedentary Behavior|Obesity
Interventions: BEHAVIORAL: Nutrition condition|BEHAVIORAL: Affective condition|BEHAVIORAL: Instrumental condition|BEHAVIORAL: Self-regulation condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Necrotizing Bacterial Dermohypodermitis-necrotizing Fasciitis Mono- or Multi-microbial Streptococcus Beta-haemolytic
Status: UNKNOWN
Conditions: Streptococcus Infection
Interventions: OTHER: DHBN-FN arm|OTHER: Control arm (Erysipelas)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Heart Failure After Heart Transplantation Due to Chronic Rejection
Status: UNKNOWN
Conditions: Cardiac Allograft Vasculopathy|Chronic Rejection of Cardiac Transplant|Graft Dysfunction
Interventions: DIAGNOSTIC_TEST: Diagnostic investigations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety, Tolerability, and PK Profile of Single and Multiple Doses TJ202 in Patient With Systemic Lupus Erythematosus
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: DRUG: Placebo|BIOLOGICAL: TJ202 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
Status: ENROLLING_BY_INVITATION
Conditions: Retinopathy of Prematurity
Interventions: OTHER: Non-Interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brightening Cream and Lasers in Post-sclerotherapy Hyperpigmentation
Status: RECRUITING
Conditions: Hyperpigmentation|Varicosis
Interventions: DEVICE: QS Nd:YAG laser|DRUG: Triple cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tRNS in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients
Status: COMPLETED
Conditions: Substance Use Disorder|Attention Deficit Disorder With Hyperactivity|Bipolar Disorder|Schizophrenia|Personality Disorder
Interventions: DEVICE: Transcranial Random Noise Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab or Ramucirumab and Pembrolizumab in Pretreated Patients With NSQ NSCLC (CARMEN-LC04)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: DRUG: SAR408701|DRUG: ramucirumab|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Arginine and Nitric Oxide in Patients With Diabetes
Status: COMPLETED
Conditions: Ketosis Prone Diabetes
Interventions: DIETARY_SUPPLEMENT: Citrulline|DIETARY_SUPPLEMENT: Alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic Telangiectasia
Status: COMPLETED
Conditions: Hereditary Hemorrhagic Telangiectasia|Epistaxis
Interventions: DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Liver Histology of Vitamin D in Patients With Non-alcoholic Steatohepatitis
Status: UNKNOWN
Conditions: Non.Alcoholic Fatty Liver Disease
Interventions: DRUG: Vitamin D|BEHAVIORAL: Lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Life Kinetik Training on Lower Limb Coordination in Ataxic Patients
Status: COMPLETED
Conditions: Multiple Sclerosis|Ataxia
Interventions: OTHER: physical therapy|OTHER: life kinetic exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Dexmedetomidine and Midazolam|DRUG: Propofol, Midazolam, and Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Inverted Flap Versus Internal Limiting Membrane Peeling in Small Full Thickness Macular Holes
Status: UNKNOWN
Conditions: Full Thickness Macular Hole
Interventions: PROCEDURE: inverted flap|PROCEDURE: peeling internal limiting membrane (ILM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin
Status: COMPLETED
Conditions: Verruca Vulgaris
Interventions: DRUG: Liquid nitrogen and cantharidin|DRUG: Liquid nitrogen and topical placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HSP-glomerulonephritis Trial: MP vs CyA
Status: COMPLETED
Conditions: Purpura, Schoenlein-Henoch
Interventions: DRUG: Methylprednisolone pulses plus prednisone versus Cyclosporine A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of Mometasone Furoate Nasal Spray and Fluticasone Propionate Nasal Spray in Patients With Perennial Allergic Rhinitis (Study P04512)
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: Placebo for MF|DRUG: Placebo for FP|DRUG: Mometasone|DRUG: Fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV)
Status: WITHDRAWN
Conditions: Vertigo|Vestibular Disease
Interventions: OTHER: Liberatory Maneuver|OTHER: Placebo maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 655130 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 655130 (spesolimab)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe
Status: COMPLETED
Conditions: Hypercholesterolemia|Coronary Heart Disease|Atherosclerosis
Interventions: DRUG: Rosuvastatin (Crestor)|DRUG: Ezetimibe|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PREFORM Study: Rotational Fractional Resection for Submental Contouring
Status: COMPLETED
Conditions: Skin Laxity|Lipodystrophy
Interventions: DEVICE: Rotational fractional resection (1.5mm Diameter Device)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Lenvatinib in Patients With Advanced Biliary Tract Carcinoma
Status: RECRUITING
Conditions: Advanced Biliary Tract Carcinoma
Interventions: DRUG: Pembrolizumab Injection [Keytruda]|DRUG: Lenvatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Synchronization Versus Conventional Synchronization
Status: RECRUITING
Conditions: Acute Respiratory Failure|Pediatric Respiratory Distress Syndrome
Interventions: DEVICE: close-loop synchronization controller with SPONT mode|DEVICE: Conventional synchronization settings with SPONT mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa-2b Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: recombinant interferon alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Levosimendan in Acute Kidney Injury After Cardiac Surgery
Status: COMPLETED
Conditions: Acute Kidney Injury|Renal Insufficiency, Acute
Interventions: DRUG: Levosimendan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Therapeutic Effects Between Intravitreal Injection of Bevacizumab With Intravitreal Injection of Bevacizumab and Targeted Laser Photocoagulation of Non Perfused Areas of Retina in Patients With Acute Retinal Vein Occlusion
Status: UNKNOWN
Conditions: Retinal Vein Occlusion With Macular Edema
Interventions: DRUG: intravitreal injection of bevacizumab|RADIATION: intravitreal injection of bevacizumab+ targeted laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pelvic Floor Muscle Training in Female CrossFit and Functional Fitness Exercisers
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Pelvic Floor Disorders|Urinary Incontinence
Interventions: OTHER: Pelvic Floor Muscle Training in female CrossFit and functional fitness exercisers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Customized V Plate Versus Conventional Miniplates of Mandibular Angle Fracture
Status: UNKNOWN
Conditions: Mandibular Fractures
Interventions: PROCEDURE: Customized V plate fixation|PROCEDURE: Conventional miniplates fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bedtime Routines and Children's Health
Status: COMPLETED
Conditions: Myopia|Dental Caries|Sleep|Asthenopia
Interventions: BEHAVIORAL: Bedtime routine|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study
Status: COMPLETED
Conditions: Orthostatic; Hypotension, Neurogenic
Interventions: DRUG: Midodrine|DRUG: Pyridostigmine Bromide|DRUG: Midodrine + pyridostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Midazolam|OTHER: Placebo|DRUG: RO7049389
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of INS115644 Ophthalmic Solution in Subjects With Ocular Hypertension or Glaucoma
Status: COMPLETED
Conditions: Ocular Hypertension|Open Angle Glaucoma
Interventions: DRUG: INS115644 Ophthalmic Solution|DRUG: Placebo|DRUG: INS115644 Ophthalmic Solution|DRUG: INS115644 Ophthalmic Solution|DRUG: INS115644 Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE)
Status: NOT_YET_RECRUITING
Conditions: Pleural Infection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postprandial Response of Individuals to Dietary Inorganic Phosphate
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: inorganic phosphate|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examining Validity and Sensitivity of Pressure-Mediated Reflection Spectroscopy
Status: COMPLETED
Conditions: Dietary Habits|Diet, Healthy
Interventions: DIETARY_SUPPLEMENT: High carotenoid juice|DIETARY_SUPPLEMENT: Placebo control - Apple juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Microbiota and Oral Status of Adult Patients With Autism Spectrum Disorders (MICAA: MICrobiota Autism Adults)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: OTHER: collection of saliva, gum fluid and/or dental plaque samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stroke Volume Variation- Guided Hemodynamic Therapy Versus Oxygen Extraction Ratio-guided Hemodynamic Therapy
Status: NOT_YET_RECRUITING
Conditions: Goal-directed Fluid Therapy
Interventions: OTHER: SVV-GDHT|OTHER: O2ER-GDHT|OTHER: conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cooperative Parent Mediated Therapy in Children With Fragile X Syndrome and Williams Syndrome
Status: UNKNOWN
Conditions: Fragile X Syndrome|Williams Syndrome
Interventions: BEHAVIORAL: Cooperative Parent Mediated Therapy" (CPMT)|BEHAVIORAL: As usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects and Underlying Mechanism of Lipid Lowering Intervention on Vascular Protection in Hypertensive Patients
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Xuezhikang|DRUG: Atorvastatin|BEHAVIORAL: Lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Distance Learning Asthma Education Program for Pediatricians (The DALI Study)
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Distributed Asthma Learning Initiative (DALI) distance learning program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Efficiency of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula
Status: UNKNOWN
Conditions: Traumatic and/or Non-traumatic Brain Injury|Critically Ill
Interventions: DIETARY_SUPPLEMENT: Peptamen® AF|DIETARY_SUPPLEMENT: Sondalis® HP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
Status: COMPLETED
Conditions: Gynecologic Cancer|Post-operative Pain
Interventions: DRUG: Bupivicaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Screening for Hepatitis B, Hepatitis C and AIDS Viruses Using Dried Blood Spot
Status: UNKNOWN
Conditions: Hepatitis B|Hepatitis C|AIDS
Interventions: DIAGNOSTIC_TEST: Blood collection using Dried Blood Spot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis
Status: COMPLETED
Conditions: Transient Tachypnea of Newborn and Fetal Acidosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Asia Primary Tube Versus Trab (TVT) Study
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DEVICE: Ahmed Glaucoma Implant|PROCEDURE: Trabeculectomy with Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Analytics and Peer-Driven Intervention for Guideline-based Care for Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: OTHER: Peer-Buddy System|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability
Status: COMPLETED
Conditions: Tobacco Use|Smoking|Smoking, Tobacco
Interventions: PROCEDURE: Lung Permeability Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma|Head and Neck Carcinoma|Head and Neck Cancer Stage IV|Head and Neck Cancers - Throat
Interventions: RADIATION: Chemoradiation|DRUG: Pamiparib|DRUG: Hydroxyurea|DRUG: Fluorouracil (5FU)|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT