pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Long-term Study of CS-3150 as Monotherapy or in Combination With Other Antihypertensive Drug in Japanese Patients With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: CS-3150
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Knowledge Implantable Cardioverter-Defibrillators (ICDs)
Status: COMPLETED
Conditions: Pacemaker|Implantable Cardioverter-Defibrillators
Interventions: OTHER: Questionnaires|OTHER: Phone Interviews|BEHAVIORAL: Educational Packet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome
Status: WITHDRAWN
Conditions: Obstetric Pain|Other Complications of Obstetric Anesthesia - Delivered
Interventions: DRUG: Dexamethasone|DRUG: Placebo|DRUG: Ropivacaine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inmediate Feeding Tolerance in Acute Pancreatitis
Status: COMPLETED
Conditions: Acute Pancreatitis Due to Gallstones
Interventions: DIETARY_SUPPLEMENT: TIME OF FEEDING
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing PM-associated CV Health Effects for Seniors
Status: COMPLETED
Conditions: Cardiovascular Diseases in Old Age
Interventions: DEVICE: Low efficiency air filtration systems|DEVICE: High efficiency air filtration systems|DEVICE: Air filtration systems without filters (sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Gel With Ecological Extra Virgin Olive Oil in Peristomal Skin Hygiene
Status: COMPLETED
Conditions: Colostomy Stoma|Ileostomy - Stoma|Peristomal Skin Complication
Interventions: OTHER: A natural neutral Ecological Extra Virgin Olive Oil based gel|OTHER: A conventional neutral gel, without Ecological Extra Virgin Olive Oil or any other olive oil-derived products
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dendritic Cell-Based Treatment Plus Immunotherapy for the Treatment of Metastatic or Unresectable Triple Negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Unresectable Triple-Negative Breast Carcinoma
Interventions: BIOLOGICAL: Alpha-type-1 Polarized Dendritic Cells|PROCEDURE: Biopsy|PROCEDURE: Computed Tomography|PROCEDURE: Leukapheresis|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of ARRY-300 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ARRY-300, MEK inhibitor; oral|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Ultrasound Guided Epidural Block in Axial SPA
Status: COMPLETED
Conditions: Epidural Block in Axial Spondyloarthritis
Interventions: DRUG: Epidural block with lidocaine and triamcinilone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influencing Wound Healing Through the Application of Hyaluronic Acid With Perfluorodecalin and Physalis Angulata Extract After Split Skin Removal From the Thigh - A Study in "Split Wound Design"
Status: WITHDRAWN
Conditions: Wound Heal
Interventions: DRUG: Ready Medical Post Treatment|DEVICE: Conventionell Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ANTERO-5: Gastric Motility in Postoperative Ileus
Status: TERMINATED
Conditions: Postoperative Ileus
Interventions: DEVICE: Panel 1 - High risk for postoperative ileus (VIPUN Gastric Monitoring System)|DEVICE: Panel 2 - Postoperative ileus arm with investigational device (VIPUN Gastric Monitoring System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Serplulimab Combined With Bevacizumab Biosimilar and HAIC in Advanced Hepatocellular Carcinoma (HCC) Patients
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: HAIC+Serplulimab（HLX10）+ Bevacizumab Biosimilar（HLX04）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Diseases|Aortic Dissection|Aortic Aneurysm, Thoracic|Aortic Ectasia|Aortic Valve Insufficiency|Bicuspid Aortic Valve|Marfan Syndrome|Ehlers-Danlos Syndrome|Loeys-Dietz Syndrome
Interventions: PROCEDURE: Surgery on the proximal aorta (aortic root +/- ascending aorta)|OTHER: Patients diagnosed with thoracic aortopathy but not operated upon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Weekly Paclitaxel and Cisplatin in FIGO IB2 and IIA2 Cervical Cancer Followed by Radical Hysterectomy
Status: UNKNOWN
Conditions: Cervical Cancer
Interventions: DRUG: paclitaxel|DRUG: cisplatin|PROCEDURE: Radical hysterectomy and bilateral pelvic lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Constant Current to Constant Voltage Stimulation in Subthalamic Deep Brain Stimulation for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: Deep Brain Stimulation (Medtronic, Activa PC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) Augmentation by D-Cycloserine as a Treatment for Depression
Status: COMPLETED
Conditions: Major Depressive Disorder|Bipolar Disorder
Interventions: DRUG: D-Cycloserine|DEVICE: tDCS (Eldith DC-Stimulator (CE certified))
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity, Safety and Tolerability of Prepandemic Influenza and Seasonal Influenza Vaccine in Adult Subjects
Status: COMPLETED
Conditions: Pandemic|Avian Influenza
Interventions: BIOLOGICAL: MF59-eH5N1|BIOLOGICAL: eTIV_a|BIOLOGICAL: MF59-eH5N1 + eTIV_a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella (MMR) Vaccine
Status: COMPLETED
Conditions: Encephalitis, Japanese|Measles|Mumps|Rubella
Interventions: BIOLOGICAL: Live attenuated SA 14-14-2 Japanese Encephalitis vaccine|BIOLOGICAL: Measles, mumps, rubella vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Pharcodynamics of AMG 853 in Adolescents With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AMG 853|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Virtual Reality VAlidation Tool for Cognitive Rehabilitation, Oriented Project for People With Psychosocial Disabilieties
Status: COMPLETED
Conditions: Mood Disorders
Interventions: DEVICE: Cognitive remedy intervention with virtual reality (CEREBRUM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)
Status: RECRUITING
Conditions: Hematologic Malignancy|GvHD|GVHD,Acute|GVHD, Chronic|Hematopoietic Stem Cell Transplant|Acute Lymphoblastic Leukemia, Adult B-Cell|Acute Lymphoblastic Leukemia, Adult T-Cell|Acute Myeloid Leukemia in Remission|Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia, in Remission|Cancer Remission
Interventions: BIOLOGICAL: TRX103
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Vitamin D Supplementation on Obesity, Inflammatory and Metabolic Markers
Status: COMPLETED
Conditions: Overweight|Hypovitaminosis D
Interventions: DIETARY_SUPPLEMENT: Vitamin D supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elective vs Therapeutic Neck Dissection in Treatment of Early Node Negative Squamous Carcinoma of Oral Cavity
Status: UNKNOWN
Conditions: Oral Cancer
Interventions: PROCEDURE: Elective neck dissection in early oral cancer|PROCEDURE: Therapeutic Neck Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Diacutaneous Fibrolysis in Painful Shoulder
Status: COMPLETED
Conditions: Shoulder Pain
Interventions: OTHER: Diacutaneous Fibrolysis|OTHER: Diacutaneous Fibrolysis (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy in Treating Patients With Refractory Advanced Solid Tumors or Hematologic Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Breast Cancer|Colorectal Cancer|Gastric Cancer|Head and Neck Cancer|Kidney Cancer|Leukemia|Lung Cancer|Melanoma (Skin)|Ovarian Cancer|Prostate Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: tanespimycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Impact of Lofexidine on Stress, Craving and Opioid Use
Status: COMPLETED
Conditions: Opioid-use Disorder|Opiate Dependence
Interventions: DRUG: Lofexidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of GONB in Patients of Migraine
Status: COMPLETED
Conditions: Chronic Migraine|Headache
Interventions: DRUG: Greater Occipital Nerve Block with dexamethasone and lidocaine|DRUG: Greater Occipital Nerve Block with 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open and Closed Platform Robotic-assisted Versus Conventional Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis|Total Knee Arthroplasty
Interventions: PROCEDURE: KUNWU Navigation TKA procedure|PROCEDURE: CORI Surgical System TKA procedure|PROCEDURE: Conventional TKA procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia
Status: NOT_YET_RECRUITING
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Moderate Intensity Continuous Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: FiO2 and Outcomes After OPCAB (the CARROT Trial)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Fraction of inspired oxygen level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing the Inflammatory Response to Experimentally-induced Insomnia Symptoms
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Effect of Intravenous Supplementation of Omega-3 Fatty Acids on Outcome of Recipients in Living Donor Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation
Interventions: DRUG: Omega 3 fatty acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prophylactic Paracetamol or Dexamethasone for Post-spinal Anesthesia Shivering
Status: COMPLETED
Conditions: Shivering
Interventions: DRUG: Paracetamol|DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Evaluation of the propertieS of the Contact LAyer Dressing LOMatuell Pro® Versus UrgoTul® in the Management of Acute Wounds
Status: COMPLETED
Conditions: Acute Wounds
Interventions: DEVICE: Lomatuell Pro|DEVICE: UrgoTul
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 0 Evaluation of [18F]MNI-958 as a Potential PET Radioligand for Imaging Tau Protein in the Brain
Status: COMPLETED
Conditions: Alzheimer Disease|Healthy Volunteers|Progressive Supranuclear Palsy
Interventions: DRUG: [18F]MNI-958|DRUG: [18F]Florbetapir|DRUG: DaTscan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy
Status: COMPLETED
Conditions: Persistent Postsurgical Pain|Breast Cancer Female|Ductal Carcinoma in Situ
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pervasive Sensing and AI in Intelligent ICU
Status: RECRUITING
Conditions: Critical Illness|Pain|Delirium|Confusion
Interventions: OTHER: Video Monitoring|OTHER: Accelerometer Monitoring|OTHER: Noise Level Monitoring|OTHER: Light Level Monitoring|OTHER: Air Quality Monitoring|OTHER: EKG Monitoring|OTHER: Vitals Monitoring|OTHER: Biosample Collection|OTHER: Delirium Motor Subtyping Scale 4 (DMSS-4)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Neoadjuvant Chemotherapy for Stage II, III Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Stage II and III Esophageal Squamous Cell Carcinoma
Interventions: DRUG: DCX|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Single Primary Dose Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV®) in Healthy Subjects
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: Live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®)|BIOLOGICAL: Live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®)|BIOLOGICAL: Live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®)|BIOLOGICAL: Live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Long-term Clinical Outcome in Patients Undergoing Remote Ischemic Conditioning Before Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction: a Follow-up Study
Status: UNKNOWN
Conditions: ST-elevation Myocardial Infarction (STEMI)
Interventions: PROCEDURE: Remote ischemic perconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intralesional Measles, Mumps, Rubella (MMR) Vaccine Versus Cryotherapy in Treatment of Multiple Common and Planter Warts
Status: COMPLETED
Conditions: Common Wart|Plantar Wart
Interventions: DRUG: Measles-Mumps-Rubella Vaccine|PROCEDURE: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Midazolam Effect in Children Undergoing Voiding Cystourethrogram (VCUG)
Status: TERMINATED
Conditions: Vesicoureteral Reflux
Interventions: DRUG: midazolam|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study of the Effect of Glucagon-like Peptide 1(GLP-1) Receptor Agonist in Combination With Metformin Therapy on Diabetes Remission in Subjects With Newly Diagnosed Type 2 Diabetes Who Are Overweight or Obese
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Exenatide|DRUG: BIAsp30|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis
Status: COMPLETED
Conditions: Embolic Stroke of Undetermined Source|Ischemic Stroke|Atrial Fibrillation and Flutter|Myocardial Infarction|Cardiac Tumor|Endocarditis|Patent Foramen Ovale
Interventions: DIAGNOSTIC_TEST: ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dendritic Cell Therapy for Brain Metastases From Breast- or Lung Cancer
Status: UNKNOWN
Conditions: Brain Metastases|Lung Cancer Metastatic|Breast Cancer Metastatic
Interventions: BIOLOGICAL: DCVax-Direct
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascularized Composite Allotransplantation of the Hand and Upper Extremity (Hand Transplant)
Status: COMPLETED
Conditions: Traumatic Amputation of Arm|Traumatic Amputation of Hand
Interventions: PROCEDURE: upper extremity/ hand transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tech-wise Driver (Technology Acceptance of Targeted ADAS for Older Adults)
Status: NOT_YET_RECRUITING
Conditions: Older Adults|Driving|Simulator
Interventions: BEHAVIORAL: The intervention name in this study is ADAS-integrated driver simulation training.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
Status: RECRUITING
Conditions: Constitutional Mismatch Repair Deficiency Syndrome|Lynch Syndrome|Malignant Glioma|Recurrent Brain Neoplasm|Recurrent Childhood Ependymoma|Recurrent Diffuse Intrinsic Pontine Glioma|Recurrent Medulloblastoma|Refractory Brain Neoplasm|Refractory Diffuse Intrinsic Pontine Glioma|Refractory Ependymoma|Refractory Medulloblastoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Conventional Magnetic Resonance Imaging|PROCEDURE: Diffusion Tensor Imaging|PROCEDURE: Diffusion Weighted Imaging|PROCEDURE: Dynamic Contrast-enhanced MR Perfusion|PROCEDURE: Dynamic Susceptibility Contrast-Perfusion-Weighted Imaging|PROCEDURE: Magnetic Resonance Spectroscopic Imaging|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biphasic Effects of Acute Alcohol Intoxication on Bystander Intervention
Status: RECRUITING
Conditions: Alcohol Intoxication
Interventions: BEHAVIORAL: Alcohol Intoxication- Ascending Limb|BEHAVIORAL: Alcohol Intoxication- Descending Limb|BEHAVIORAL: No Alcohol Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibody Response to Prophylactic QHPV Vaccine at 48 Months Among HIV-infected Girls and Boys
Status: COMPLETED
Conditions: HPV Vaccine|HPV Infection|HIV-1-infection
Interventions: DRUG: Quadrivalent HPV [Type 6, 11, 16 and 18] L1 Virus-Like Particle Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Compare the Effect of Two Different Types of Humidifier on the Endotracheal Tube Patency
Status: COMPLETED
Conditions: Cancer of Head and Neck
Interventions: DEVICE: heated humidifier|DEVICE: mist humidifier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
Status: WITHDRAWN
Conditions: Metastatic Melanoma|Metastatic Breast Cancer|Advanced Renal Cell Carcinoma|Squamous Cell Carcinoma of Head and Neck|Non-small Cell Lung Cancer Stage III|Healthy
Interventions: DIAGNOSTIC_TEST: single arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Everolimus in Combination With Imatinib Mesylate in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Adult Synovial Sarcoma|Recurrent Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: OTHER: diagnostic laboratory biomarker analysis|DRUG: everolimus|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension
Status: COMPLETED
Conditions: Symptomatic Orthostatic Hypotension
Interventions: DRUG: Midodrine HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stenting Malignant Jaundice for Quality of Life
Status: COMPLETED
Conditions: Bile Duct Neoplasms Malignant
Interventions: PROCEDURE: ERCP with 10 French biliary plastic stent placement|PROCEDURE: ERCP with 11.5 French biliary plastic stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Boceprevir in Combination With Peginterferon Alfa-2a and Ribavirin in Participants With Chronic Hepatitis C Genotype 1 Who Failed Prior Treatment With Peginterferon/Ribavirin (Study P05685AM2)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Boceprevir|OTHER: Placebo|BIOLOGICAL: Peginterferon alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Explore the Efficacy and Safety of Camrelizumab Combined With SHR1020 in the Treatment of Advanced Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: camrelizumab|DRUG: SHR1020
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Continuous Positive Airway Pressure (CPAP) Treatment in the Control of Refractory Hypertension
Status: COMPLETED
Conditions: Sleep Apnea|Hypertension
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-Time Assessment of Cryoballoon Pulmonary Vein Isolation Using a Novel Circular Mapping Catheter
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Cryoballoon ablation.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Selinexor in Combination With Azacitidine and Venetoclax (SAV Regimen) in Treatment Naïve Participants With Acute Myeloid Leukemia
Status: RECRUITING
Conditions: AML, Adult
Interventions: DRUG: Selinexor|DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk of Stroke and Silent Cerebrovascular Thromboembolism After Cardioversion of Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Cardioversion|Cerebrovascular Stroke
Interventions: PROCEDURE: Cardioversion|DRUG: Oral Anticoagulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
Status: RECRUITING
Conditions: Atypical Hemolytic Uremic Syndrome
Interventions: DRUG: Crovalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: King Vision Video Laryngoscope Versus Glidescope Video Laryngoscope
Status: TERMINATED
Conditions: Difficult Intubation
Interventions: DEVICE: King Vision Video Laryngoscope|DEVICE: Glidescope Video Laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Genital Laser Treatment in Postmenopausal Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Dyspareunia|Menopause|Sexual Activity|Atrophy Vulva
Interventions: OTHER: Survey results before and after laser treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Varenicline on Cognitive Function in Cigarette Smokers With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4SC-202 in Combination With Pembrolizumab in Patients Primary Refractory/Non-responding to Prior Anti-PD-1 Therapy
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: 4SC-202 in combination with Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomine vs Dexamethasone in TAB Block for Abdominal Surgries
Status: UNKNOWN
Conditions: Anesthesia
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Auditory Cues on Gait Mechanics in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Metronome Normal|OTHER: Metronome Slow|OTHER: Metronome Fast|OTHER: Music Normal|OTHER: Music Slow|OTHER: Music Fast|OTHER: No Auditory cueing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CUped: An Approach to Motor Recovery Post-Stroke, Not Compensation
Status: RECRUITING
Conditions: Stroke|Hemiplegia
Interventions: BEHAVIORAL: Exercise with CUped - a motor-assisted, split crank pedaling device and undergo 50 m of gait training.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Evaluation of N1539 Following Bunionectomy Surgery
Status: COMPLETED
Conditions: Pain, Post-operative
Interventions: DRUG: N1539|DRUG: Intravenous Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Role of PlasmaJet in Patients Undergoing Groin Node Dissection for Vulval Cancer
Status: TERMINATED
Conditions: Vulvar Cancer|Groin Node
Interventions: DEVICE: PlasmaJet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-FAPI PET/CT in Patients With Various Types of Cancer
Status: UNKNOWN
Conditions: Tumor|Positron-Emission Tomography|Metastasis
Interventions: DRUG: 68Ga-DOTA/NOTA-FAPI-04|DIAGNOSTIC_TEST: PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Umbilical Cord Blood-derived Mesenchymal Stem Cells for the Treatment of Steroid-refractory Acute or Chronic Graft-versus-host-disease
Status: UNKNOWN
Conditions: Graft-Versus-Host Disease|GVHD|Allogeneic Hematopoietic Transplant|Disorder Related to Transplantation
Interventions: BIOLOGICAL: Human umbilical cord blood-derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Coronary Heart Disease With Amiloride
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: Amiloride|DRUG: Nitrates, clopidogrel, aspirin, statins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Clozapine Versus Olanzapine for Treatment-resistant Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Clozapine|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Potential Pharmacokinetic Interaction and Pharmacodynamic Effects on Renal Parameters of Bumetanide (1mg) and Dapagliflozin (10 mg) When Co-administered in Healthy Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Bumetanide|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Herceptin (Trastuzumab) Monotherapy in Patients With Metastatic Urothelial Cancer
Status: TERMINATED
Conditions: Urinary Tract Cancer
Interventions: DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sipuleucel-T With Immediate vs. Delayed Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Blockade for Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: SipT Treatment|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Non-invasive Ventilation Versus High-flow Oxygen in Patients With Hypoxemic Respiratory Failure Undergoing Fiberoptic Bronchoscopy.
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DEVICE: non-invasive ventilation|DEVICE: high-flow oxygen|PROCEDURE: fiberoptic bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Tumor Infiltrating Lymphocytes Plus IL-2 Following Non-Myeloablative Lymphocyte Depleting Chemo Regimen Alone or in Conjunction With 12Gy Total Body Irradiation (TBI...
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Melanoma|Skin Cancer
Interventions: DRUG: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Young TIL|RADIATION: Total Body Irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Bioequivalence of Test Oral Formulation of Alpha Lipoic Acid 600 mg HR Film Coated Tablets of Ilko Ilac San. Ve Tic. A.S. Versus Reference Thioctacid (Alpha Lipoic Acid) 600 mg HR Film Coated Tablets of Meda Pharma GmbH& CO .KG, Germany.
Status: COMPLETED
Conditions: Peripheral (Sensorimotor) Diabetic Polyneuropathy
Interventions: DRUG: Alpha Lipoic acid 600 mg HR film coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RAndomized Comparison of Efficacy and Safety of Lipid-lowerING With Statin Monotherapy Versus Statin/Ezetimibe Combination for High-risk Cardiovascular Diseases (RACING Trial)
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Cerebrovascular Disease|Peripheral Atherosclerotic Disease
Interventions: DRUG: Rosuvastatin|DRUG: Rosuvastatin plus ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms for Alcohol Treatment Change [MATCH] Study
Status: COMPLETED
Conditions: Alcohol Consumption
Interventions: BEHAVIORAL: Drinking Cognition Feedback (DCF)|BEHAVIORAL: Alcohol Risk Feedback (ARF)|BEHAVIORAL: Adaptive Goal Support (AGS)|BEHAVIORAL: COMBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Advanced Nurses vs. General Practitioners for the Management of Outpatient Alcohol Detox: a Safety and Cost Comparison
Status: TERMINATED
Conditions: Alcohol Dependence
Interventions: PROCEDURE: Advanced Nurse (AN)|PROCEDURE: General Practitioner (GP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravitreal Bevacizumab for Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: bevacizumab intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Computer-Based Intervention for Alcohol Misuse in the Emergency Department
Status: COMPLETED
Conditions: Alcohol Consumption
Interventions: BEHAVIORAL: Computer-based PAF|BEHAVIORAL: Computer-based Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Performance of the Infiniti Vision and the Series 20000 Legacy Phacoemulsification Systems
Status: COMPLETED
Conditions: Cataract Extraction
Interventions: DEVICE: Legacy 20000|DEVICE: Infinit system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SPH4336 in Combination With Endocrine Therapy in the Treatment of Locally Advanced or Metastatic Breast Cancer
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Breast Cancer
Interventions: DRUG: SPH4336 Tablets|DRUG: SPH4336 Tablets Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Foot Core Exercises or Foot Orthotics in Symptomatic Flexible Flatfoot
Status: RECRUITING
Conditions: Flatfoot, Flexible
Interventions: OTHER: Foot muscle strengthening|OTHER: Foot orthotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial on the Efficacy, Safety and Immunogenicity of Live-Attenuated Influenza Vaccine (LAIV)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Live-Attenuated influenza Vaccine(LAIV)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Thalidomide and Temozolomide in Relapsed or Progressive CNS Disease or Neuroblastoma
Status: COMPLETED
Conditions: Central Nervous System Tumor, Pediatric|Neuroblastoma
Interventions: DRUG: temozolomide|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Quality of Life and Outcomes in Patients With Primary Renal Cell Carcinoma Treated With SBRT
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: RADIATION: Stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sotagliflozin Versus Placebo in Chinese Patients With Type 2 Diabetes Mellitus Not Adequately Controlled by Diet and Exercise
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sotagliflozin (SAR439954)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetics of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification
Status: COMPLETED
Conditions: Intraocular Lens Replacement
Interventions: DRUG: OMS302|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Prevention and Treatment of Pyrotinib Associated Diarrhea With Traditional Chinese Medicine
Status: UNKNOWN
Conditions: Diarrhea Caused by Antitumor Drugs
Interventions: DRUG: Traditional Chinese Medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk of GAstric Adenocarcinoma After Cephalic Duodenopancreatectomy
Status: RECRUITING
Conditions: Cephalic Duodenopancreatectomy 10 or More Years Ago
Interventions: DIAGNOSTIC_TEST: high digestive endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Radial Shock Waves Therapy in the Treatment of Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Musculoskeletal Manipulations|Extracorporeal Shockwave Therapy
Interventions: OTHER: Radial Shock Wave Therapy|OTHER: Manual Therapy|OTHER: placebo shock waves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tracheal Dosage of Amylase : a New Surrogate for Microaspirations in Ventilated ICU Patients
Status: COMPLETED
Conditions: Ventilated-acquired Pneumonia
Interventions: OTHER: dosage of amylase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise and Transcranial Magnetic Stimulation: Increasing Brain Plasticity in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Sham rTMS|OTHER: Real rTMS|BEHAVIORAL: Supervised aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: VSL#3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism
Status: ENROLLING_BY_INVITATION
Conditions: Trauma Injury|Thromboembolism|Venous Thromboembolism
Interventions: DRUG: Thrombate infusion|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Stromal Vascular Fraction Versus Platelet Rich Plasma in Treatment of Androgenitic Alopecia
Status: NOT_YET_RECRUITING
Conditions: Androgenetic Alopecia
Interventions: PROCEDURE: stromal vascular fraction or platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence
Status: COMPLETED
Conditions: Brain Metastases|Adult Solid Tumor
Interventions: RADIATION: stereotactic radiosurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Xylitol on Subsequent Energy Intake
Status: COMPLETED
Conditions: Energy Intake|Gastrointestinal Hormones|Glycemic Control|Appetite|Satiation
Interventions: DIETARY_SUPPLEMENT: Xylitol|DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Acesulfame Potassium|DIETARY_SUPPLEMENT: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PROS Smokebusters: Adolescent Smoking Cessation in Pediatric Primary Care
Status: COMPLETED
Conditions: Health Care Quality, Access, and Evaluation|Smoking Cessation
Interventions: BEHAVIORAL: smoking cessation, practice change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cyclosporine A to Treat Hypertrophic Cardiomyopathy (HCM)
Status: COMPLETED
Conditions: Cardiomyopathy, Hypertrophic|Heart Hypertrophy
Interventions: DRUG: Cyclosporine A
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Insomnia Treatment for Women Veterans
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Acceptance and the Behavioral Changes to Treat Insomnia|BEHAVIORAL: Cognitive behavioral therapy for insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Busulfan Plus Melphalan Conditioning Regimen for Lymphoid Malignancies or Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma|Lymphoma
Interventions: DRUG: Busulfan|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Vibration in Patients With Severe Acquired Brain Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Acquired Brain Injury|Dysphagia
Interventions: DEVICE: Novafon® Pro|OTHER: Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proximal Row Carpectomy vs Four-corner Fusion for Osteoarthritis of the Wrist
Status: RECRUITING
Conditions: Wrist Osteoarthritis|Scapholunate Advanced Collapse
Interventions: PROCEDURE: Proximal Row Carpectomy|PROCEDURE: Four-corner fusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm|Coronary Heart Disease NOS|Unheralded Corronary Death|Intracerebral Haemorrhage|Heart Failure|Ischemic Stroke|Myocardial Infarction|Stroke|Peripheral Arterial Disease|Stable Angina Pectoris|Subarachnoid Haemorrhage|Transient Ischemic Attack|Unstable Angina|Cardiac Arrest, Sudden Cardiac Death
Interventions: OTHER: No treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology (PVC-RAM) Trial
Status: COMPLETED
Conditions: Surgery|Perioperative Complication|COVID
Interventions: OTHER: Virtual Care and Remote Automated Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Incisional Hernia Repair by Abdominal Wall Component Release With Contemporary Onlay Mesh Fixation
Status: ACTIVE_NOT_RECRUITING
Conditions: Incisional Hernia|Onlay Mesh|Abdominal Wall Component Release
Interventions: PROCEDURE: Incisional Hernia Repair by Abdominal Wall Component Release with Contemporary Onlay Mesh Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Electronic Population Health and Personal Health Record Tools to Improve Once Lifetime Hepatitis C Screening
Status: COMPLETED
Conditions: Hepatitis C
Interventions: OTHER: Bulk ordering and bulk messaging|OTHER: Routine alerting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SCREENING