pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab in Pretreated Participants With Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma Gastric|Gastrooesophageal Cancer
Interventions: DRUG: Ramucirumab (CYRAMZA®)|DRUG: Tusamitamab ravtansine (SAR408701)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Extracorporeal Shock Waves on Hypertrophy Scar
Status: UNKNOWN
Conditions: Hypertrophy; Scar
Interventions: DEVICE: extracorporeal shock-wave|OTHER: massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
Status: COMPLETED
Conditions: Disorder Related to Lung Transplantation|Brain Death|Graft Failure|Primary Graft Dysfunction
Interventions: PROCEDURE: EVLP Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Use of Trifluoperazine in Transfusion Dependent DBA
Status: TERMINATED
Conditions: Diamond Blackfan Anemia|Pure Red Cell Aplasia
Interventions: DRUG: Trifluoperazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Exercise Using Digital Healthcare System in Patients With Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteo Arthritis Knee
Interventions: DEVICE: Rehabilitation using Digital Healthcare System (Uincare Homeplus)|OTHER: Conventional Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Routine Or Selective Application of a Face Mask for Preterm Infants at Birth: the ROSA Trial
Status: COMPLETED
Conditions: Infant, Premature, Diseases|Continuous Positive Airway Pressure|Positive-Pressure Respiration|Resuscitation|Respiratory Distress Syndrome, Newborn
Interventions: OTHER: Face mask application for CPAP and/or PPV delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adverse Airway Effects From Tobacco and E-Cigarettes
Status: UNKNOWN
Conditions: Airway Morbidity|Smoking Cessation|Nicotine Adverse Reaction|Smoking, Tobacco|Smoking, Cigarette
Interventions: DEVICE: Electronic cigarette use|OTHER: Control regular cigarette smokers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Varenicline on Smoking Lapse in Smokers With and Without Schizophrenia
Status: COMPLETED
Conditions: Craving|Smoking|Schizophrenia
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment
Status: WITHDRAWN
Conditions: Nicotine Dependence
Interventions: DRUG: Nicotine patch|OTHER: ENDS|OTHER: Placebo patch|OTHER: Placebo ENDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Bi-annual CDTI on the Incidence of Epilepsy in an Onchocerciasis-endemic Area
Status: COMPLETED
Conditions: Onchocerciasis|Epilepsy
Interventions: DRUG: Bi-annual CDTI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Foot and Ankle Arthrodesis or Osteotomy With Io-Fix Type Fixation
Status: ACTIVE_NOT_RECRUITING
Conditions: Foot and Ankle Arthrodesis|Foot and Ankle Osteotomy
Interventions: OTHER: Follow-up of Io-Fix type fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Dx-pH Probe in Diagnosing Extra-esophageal Reflux Disease
Status: COMPLETED
Conditions: GERD|Larynx Disease
Interventions: DEVICE: Dx-pH Probe|PROCEDURE: Manometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Feasibility and Efficacy of Telecommunication Platforms as an Adjunctive Clinical Tool for a Parkinson's Disease Clinic
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: PROCEDURE: Telemedicine: Virtual visits (videoconferences, texts)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of DHEA/Exercise on Bone, Muscle and Balance
Status: COMPLETED
Conditions: Osteoporosis|Frailty
Interventions: DIETARY_SUPPLEMENT: DHEA|BEHAVIORAL: Yoga|DIETARY_SUPPLEMENT: Placebo|BEHAVIORAL: Aerobics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Binocularly Balanced Viewing Study
Status: COMPLETED
Conditions: Amblyopia
Interventions: DEVICE: Balanced Binocular Viewing (BBV)|OTHER: Standard Therapy - Occlusion (patching) or blurring (atropine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Ave-CRT Study for Newly Diagnosed Metastatic Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Tumor|Metastatic Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pilates Training on Respiratory Muscle Strenght in Patients With Ankylosing Spondylitis
Status: UNKNOWN
Conditions: Ankylosing Spondylitis
Interventions: OTHER: Pilates Training|OTHER: Conventional exercise programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TCH Versus EC-TH as Neoadjuvant Treatment for HER2-Positive Breast Cancer
Status: COMPLETED
Conditions: HER2-Positive Breast Cancer
Interventions: DRUG: TCH (docetaxel/carboplatin/trastuzumab) versus EC-TH(epirubicin/cyclophosphamide followed by docetaxe plus trastuzumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of C106 in Healthy Subjects
Status: COMPLETED
Conditions: Safety Issues|Tolerance|Idiopathic Pulmonary Fibrosis|Pulmonary Hypertension
Interventions: DRUG: C106 solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Topical and Systemic Decolonization of Staphylococcus Aureus (SA) in Pediatric Cystic Fibrosis (CF) Patients
Status: WITHDRAWN
Conditions: Cystic Fibrosis
Interventions: DRUG: decolonization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of Somatropin in Adults With Growth Hormone Deficiency Caused by Trauma and/or Head Injury
Status: TERMINATED
Conditions: Brain Injuries|Growth Hormone Deficiency Dwarfism
Interventions: GENETIC: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Point of Care Ultrasound Change Needle Insertion Location During Routine Bedside Paracentesis?
Status: COMPLETED
Conditions: Ascites|Paracentesis|Point of Care Ultrasound (POCUS)
Interventions: DIAGNOSTIC_TEST: Abdominal Point of Care Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy
Status: RECRUITING
Conditions: Hepatic Encephalopathy
Interventions: DRUG: Rifaximin|DRUG: Nitazoxanide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-nasal Drainage as an Extraesophageal Manifestation of Reflux
Status: COMPLETED
Conditions: Postnasal Drainage
Interventions: DRUG: Rabeprazole 20 mg twice a day for 90-day period treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Efficacy of Mizoribine With Mycophenolate Mofetil for Living Related Kidney Transplantation Recipients
Status: RECRUITING
Conditions: Kidney Transplant Immunosuppression
Interventions: DRUG: Mizoribine|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avastin and Tarceva for Upper Gastrointestinal Cancers
Status: COMPLETED
Conditions: Cholangiocarcinoma|Gallbladder Cancer
Interventions: DRUG: Erlotinib and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Surgical Treatment of Periimplantitis
Status: COMPLETED
Conditions: Peri-Implantitis and Peri-implant Mucositis
Interventions: PROCEDURE: ultrasonic|PROCEDURE: erythritol|DRUG: metronidazole gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stepped Care for Binge Eating Disorder: Predicting Response to Minimal Intervention in a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Binge Eating Disorder
Interventions: BEHAVIORAL: Group Psychodynamic Interpersonal Psychotherapy|BEHAVIORAL: Unguided Self-Help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Infusion Rituximab, Hematologic, Oncologic, and Rheumatologic Disorders
Status: COMPLETED
Conditions: Hematologic Disorders|Oncologic Disorders|Rheumatologic Disorders
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral LAT8881 in Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain|Diabetic Peripheral Neuropathy (DPN)|Post Herpetic Neuralgia (PHN)
Interventions: DRUG: LAT8881|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing contrAst Induced Nephropathy After TranscathEter Aortic Valve Replacement
Status: UNKNOWN
Conditions: Aortic Valve Disease|Chronic Kidney Disease|Contrast Induced Nephropathy|Acute Kidney Injury
Interventions: DRUG: sodium bicarbonate|DRUG: hypotone saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PSMA-PET Imaging Before and After ADT in Advanced SDC Patients
Status: UNKNOWN
Conditions: Salivary Gland Cancer|Salivary Duct Carcinoma
Interventions: DIAGNOSTIC_TEST: 68Ga-PSMA-PET/CT|DIAGNOSTIC_TEST: 18FDG-PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the OtoBand as a Treatment to Reduce the Perceived Loudness of Tinnitus
Status: UNKNOWN
Conditions: Tinnitus
Interventions: DEVICE: Otoband|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multimodal PT With and Without Proprioceptive Training in Lumber FJS
Status: RECRUITING
Conditions: Facet Joint Pain
Interventions: OTHER: Multimodal Physical therapy|OTHER: Proprioceptive training along with and Multimodal Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery
Status: WITHDRAWN
Conditions: Hernia|Ventral Hernia|Abdominal Hernia
Interventions: DRUG: Fibrin Sealant|DRUG: Silver Microparticles
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Robotic or Open Radical Cystectomy in Treating Patients With Bladder Cancer
Status: TERMINATED
Conditions: Stage 0is Bladder Urothelial Carcinoma|Stage I Bladder Urothelial Carcinoma|Stage II Bladder Urothelial Carcinoma|Stage III Bladder Urothelial Carcinoma
Interventions: OTHER: Questionnaire Administration|PROCEDURE: Radical Cystectomy|PROCEDURE: Radical Cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: DFN-11 Injection in Episodic Migraine With or Without Aura
Status: COMPLETED
Conditions: Episodic Migraine
Interventions: DRUG: DFN-11|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide in Treating Patients With High Risk Acute Myeloid Leukemia in Remission
Status: COMPLETED
Conditions: Alkylating Agent-Related Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
Status: COMPLETED
Conditions: Substance Use Disorders|Bipolar Disorder|Mood Disorders
Interventions: DRUG: Quetiapine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMX-150 Cream for Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: DRUG: IMX-150|DRUG: IMX-150|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RAD001 Study in Treatment of Relapsed or Refractory Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Acute Lymphocytic Leukemia
Interventions: DRUG: Everolimus (RAD001)|DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Doxorubicin|DRUG: Dexamethasone|DRUG: Mesna|DRUG: Methotrexate|DRUG: Ara-C (Cytarabine)|DRUG: Methylprednisone|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensory and Opioid Mechanisms of Affective Touch
Status: COMPLETED
Conditions: Pain|Touch
Interventions: OTHER: Placebo|DRUG: Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laparotomy vs. Drainage for Infants With Necrotizing Enterocolitis
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Enterocolitis, Necrotizing|Intestinal Perforation
Interventions: PROCEDURE: Laparotomy|PROCEDURE: Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Safety Study of NVG-291 in Healthy Adults
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DRUG: NVG-291|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Laryngeal Mask Airways in Sinonasal Surgery
Status: COMPLETED
Conditions: Conditions Requiring Sinonasal Surgery
Interventions: DEVICE: Mallinckrodt Endotracheal Tube (ETT)|DEVICE: Laryseal Laryngeal mask airway (LMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Study of a Vaginal Lubrication Ring to Treat the Symptoms of Vaginal Dryness
Status: COMPLETED
Conditions: Menopausal and Perimenopausal Disorder, Unspecified|Atrophic Vaginitis
Interventions: DEVICE: Vaginal Lubrication Ring for Vaginal Dryness
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary Hyperparathyroidism
Status: COMPLETED
Conditions: Primary Hyperparathyroidism|Primary Hyperparathyroidism Due to Adenoma
Interventions: DIAGNOSTIC_TEST: 11C-choline PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intraperitoneal Paclitaxel With XELOX in Gastric Cancer With Peritoneal Metastasis
Status: RECRUITING
Conditions: Stomach Neoplasms|Paclitaxel|Peritoneal Metastases
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Versus Delayed Orthodontic Treatment After Periodontal Surgery on Periodontal Health in Periodontally Compromised Patients
Status: COMPLETED
Conditions: Periodontitis, Adult
Interventions: PROCEDURE: Fixed Orthodontic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Childhood Obesity Through a Mindfulness-Based Parent Stress Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Child Obesity
Interventions: BEHAVIORAL: Parenting Mindfully for Health Nutrition (PMH)|BEHAVIORAL: Contact Control Nutrition (C+N)|OTHER: Non-randomized historical control (WLC) assessment only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Investigating the Association of NP137 With mFOLFIRINOX in Locally Advanced Pancreatic Ductal Adenocarcinoma
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: NP137|DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: Calcium levofolinate|DRUG: 5 FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Sensory Rehabilitation Program on Olfactory-gustatory Alterations in Patients Treated With Chemotherapy for Haematological Cancer
Status: RECRUITING
Conditions: Multiple Myeloma|Olfactivo-gustatory Disorder|Lymphoma|Haematological Cancer
Interventions: OTHER: Multifactorial sensory rehabilitation workshops|OTHER: Usual care|OTHER: Tests and Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A 24-month Clinical Evaluation of Different Bulk-fill Restorative Resins in Class II Restorations
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Tetric EvoCeram Bulkfill|OTHER: Surefil SDR Flowable bulkfill|OTHER: everX fiber-reinforced resin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone Before Peginterferon and Ribavirin for Hepatitis C Infection in HIV/HCV-Coinfected Patients With Insulin Resistance
Status: COMPLETED
Conditions: HIV-1 and Hepatitis C Co-Infection
Interventions: DRUG: pioglitazone|DRUG: peginterferon|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Rehabilitation for Patients With Critical Limb Ischemia After Revascularization
Status: UNKNOWN
Conditions: Peripheral Arterial Disease|Critical Limb Ischemia
Interventions: BEHAVIORAL: Supervised Exercise Program|OTHER: Best Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Istaroxime in Acute Decompensated Heart Failure Patients
Status: WITHDRAWN
Conditions: Heart Failure
Interventions: DRUG: Istaroxime|DRUG: Istaroxime|DRUG: Istaroxime|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin in Depression Resistant to Standard Treatments
Status: UNKNOWN
Conditions: Treatment Resistant Depression
Interventions: COMBINATION_PRODUCT: Psilocybin assisted therapy|COMBINATION_PRODUCT: Placebo assisted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ridge Splitting Using Autogenous Bone Wedge Versus the Conventional Intercortical Augmentation Technique in Horizontally Deficient Anterior Maxilla
Status: RECRUITING
Conditions: Horizontal Ridge Deficiency
Interventions: PROCEDURE: autogenous bone wedge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Respiratory Complications Associated With COVID19,Influenza ,Metapneumovirus,RSV Infection Using ProTrans®
Status: RECRUITING
Conditions: COVID-19 Acute Respiratory Distress Syndrome|Influenza A|Metapneumovirus Pneumonia|Respiratory Syncytial Virus (RSV)
Interventions: BIOLOGICAL: ProTrans®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UPTAKE - Virtual Care: Virtual Home Hospital With Remote Monitoring to Reduce Acute Care Hospitalization
Status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury
Interventions: OTHER: Virtual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Combination Product: BCI-024 + BCI-049
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Safety of Benjakul Recipe in Treating Primary Osteoarthritis of Knee Compared With Diclofenac
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Benjakul recipe|DRUG: diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic-pharmacodynamic Interaction Between Each of Three Different Single Doses of BIA 9-1067 and a Single-dose of Controlled-release 100/25 mg Levodopa/Carbidopa
Status: COMPLETED
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: BIA 9-1067|DRUG: Placebo|DRUG: Sinemet® CR 100/25
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nimodipine in Vestibular Schwanommas
Status: RECRUITING
Conditions: Vestibular Schwannoma
Interventions: DRUG: NiMODipine Injectable Solution|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination of Alpelisib and Trametinib in Progressive Refractory Meningiomas
Status: RECRUITING
Conditions: Meningioma
Interventions: DRUG: Trametinib|DRUG: Alpelisib|BIOLOGICAL: Blood sample|DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological Study of the Critical Closing Airway Pressure in a Population of Didgeridoo Players
Status: COMPLETED
Conditions: Sleep Apnea Syndromes
Interventions: OTHER: Measurement of critical airway closing pressure|OTHER: Respiratory function tests|OTHER: pharyngometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Oral Administration of DCI to Women With PCOS
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: DCI|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men
Status: COMPLETED
Conditions: Skeletal Muscle|Extracellular Matrix|Amino Acids Metabolism|Exercise|Dietary Supplements
Interventions: DIETARY_SUPPLEMENT: Essential Amino Acid|DIETARY_SUPPLEMENT: Collagen Peptide|DIETARY_SUPPLEMENT: Maltodextrin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HealiAid in the Treatment of Different Wounds
Status: COMPLETED
Conditions: Venous Ulcers|Bedsores|Diabetic Foot Wound|Burn Wound
Interventions: DEVICE: HealiAid Collagen Wound Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Camrelizumab Combined With Apatinib Mesylate for Perioperative Treatment of Resectable Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Immunotherapy|Molecular Targeted Therapy
Interventions: DRUG: Camrelizumab|DRUG: Apatinib Mesylate|PROCEDURE: TACE treatment|PROCEDURE: Radical surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of TENS on Patient Outcomes After Laparoscopic Cholecystectomy: A Randomized Controlled Study
Status: RECRUITING
Conditions: Cholecystitis; Gallstone|Cholecystolithiasis
Interventions: OTHER: Experimental group (Transcutaneous Electrical Nerve Stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controlled-trial.
Status: COMPLETED
Conditions: Kaposi Sarcoma|Human Immunodeficiency Virus|Immune Reconstitution Syndrome
Interventions: DRUG: Valganciclovir|DRUG: Antiretroviral Combinations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Single Arm Study of Obinutuzumab Short Duration Infusion in Patients With Previously Untreated Advanced Follicular Lymphoma
Status: COMPLETED
Conditions: Advanced Follicular Lymphoma
Interventions: DRUG: Obinutuzumab|DRUG: Bendamustine|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone/Prednisolone/Methylprednisolone|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zona Pellucida Thinning Versus Drilling During Laser-assisted Hatching
Status: RECRUITING
Conditions: Infertility
Interventions: PROCEDURE: Zona pellucida thinning|PROCEDURE: Zona pellucida drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Removal of Surgical Staples After Cesarean Delivery. Randomized Control Trial.
Status: COMPLETED
Conditions: Cesarean Section; Wound, Infection (Following Delivery)
Interventions: OTHER: Removal of surgical clips at day 4 post operative vs day 8 post operative|PROCEDURE: Elective cesarean delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: TAB08 in Patients With Psoriasis Vulgaris, Not Adequately Controlled With Current Treatment
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: TAB08|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Synergic Effects of Physical Activity and Probiotic on Gut Immune System and Quality of Life of Breast Cancer Survivors.
Status: WITHDRAWN
Conditions: Breast Cancer Females
Interventions: OTHER: Physical Exercise and probiotic group|DIETARY_SUPPLEMENT: Probiotic group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Flavonoid Supplementation on Cognition and Neural Mechanisms in Healthy Older Adults
Status: UNKNOWN
Conditions: Mental Processes
Interventions: DIETARY_SUPPLEMENT: Cocoa-Flavanol Supplements|DIETARY_SUPPLEMENT: Control Supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Methods Study to Characterize Early Indicators of Weight Loss in People
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: caloric restriction - 10%|BEHAVIORAL: caloric restriction - 25%|BEHAVIORAL: caloric restriction - 50%|BEHAVIORAL: caloric restriction - Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustainable Efficacy of Vardenafil OD Versus Vardenafil PRN in Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)|DRUG: Levitra (Vardenafil, BAY38-9456)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Crossover Study on the Effect of Omegaven in Combination With Different Lipid Emulsions in Home Parenteral Nutrition
Status: COMPLETED
Conditions: Parenteral Nutrition
Interventions: DRUG: ClinOleic (baseline)|DRUG: ClinOleic + Omegaven|DRUG: Lipoplus (baseline)|DRUG: Lipoplus + Omegaven|DRUG: SMOFlipid (baseline)|DRUG: SMOFlipid + Omegaven
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: DEVICE: active tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression
Status: RECRUITING
Conditions: Recurrent Ovarian Cancer|Folate Receptor-Alpha Positive
Interventions: DRUG: Mirvetuximab Soravtansine|DRUG: Lubricating Eye Drops|DRUG: Prednisolone acetate ophthalmic suspension 1% eye drops|DRUG: Brimonidine tartrate ophthalmic solution eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an Individual Counseling Session on Physical Activity Level of Individuals With COPD
Status: COMPLETED
Conditions: COPD
Interventions: BEHAVIORAL: Physical Activity Counseling session|OTHER: Pulmonary Reabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: dalcetrapib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury
Status: COMPLETED
Conditions: Cirrhosis, Liver|AKI
Interventions: DRUG: Dextran 40
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HPV Test-and-Treat-Strategy Versus Cytology-based Strategy for Prevention of CIN2+ in HIV-Infected Women
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: PROCEDURE: Cervical Cryotherapy|PROCEDURE: Loop Electrosurgical Excision Procedure (LEEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing State of the Art Remote Glucose Monitoring at Diabetes Camp
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Mini-glucagon|DEVICE: Remote monitoring|DIETARY_SUPPLEMENT: Carbohydrates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Tobi Inhalant Product|DRUG: Nebcin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact on Quality of Life With Pulmonary RehAbilitation After Pulmonary eMBOlism: RAMBO Study
Status: RECRUITING
Conditions: Pulmonary Embolism|Quality of Life and Dyspnea
Interventions: OTHER: Pulmonary rehabilitation (PR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immunogenicity and Safety of a Booster Dose of Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Hib Vaccine in 365-569 Days Old Healthy Infants
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b (Hib) Infection
Interventions: BIOLOGICAL: Haemophilus influenzae type b (Hib) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intra-myometrial Vasopressin During Cesarean Section in Placenta Previa
Status: COMPLETED
Conditions: Placenta Previa
Interventions: DRUG: Intramyometrial Vasopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Multi-mode Thermophysical Immunotherapy Study for Breast Cancer Liver Metastases
Status: NOT_YET_RECRUITING
Conditions: Breast Neoplasms|Liver Neoplasms|Metastasis
Interventions: DEVICE: Multi-mode tumor treatment system|DEVICE: Radiofrequency ablation therapeutic apparatus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Brachytherapy in Treating Patients With Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Adenocarcinoma|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer
Interventions: RADIATION: Internal Radiation Therapy|DRUG: Bicalutamide|DRUG: Leuprolide Acetate|DRUG: Goserelin Acetate|DRUG: Triptorelin Pamoate|DRUG: Degarelix|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib Combined With Chemotherapy Versus Chemotherapy in Second-line Gastric Cancer Receiving Prior Anti-PD-1 Therapy
Status: UNKNOWN
Conditions: Gastric Cancer|Randomized Controlled Study
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychosocial Mobile Application (THRIVE-M) for Patients With Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: BEHAVIORAL: THRIVE-M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Two Osteoporosis Drugs on Prosthetic Bone Mineral Density (BMD) Loss After Total Hip Arthroplasty(THA)
Status: UNKNOWN
Conditions: Bone Density|Arthroplasty, Replacement, Hip
Interventions: DRUG: alendronate, alfacalcidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone and Exercise Training: Effects on HIV-Infected People With Insulin Resistance, Hypertriglyceridemia, and Adipose Tissue Maldistribution
Status: COMPLETED
Conditions: HIV Infections|Insulin Resistance
Interventions: DRUG: rosiglitazone (Avandia)|BEHAVIORAL: Aerobic and weight lifting exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Impact of the Genetic Background as a Risk Factor for Atherosclerotic Cardiovascular Disease in the Brazilian Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Acute MI|Stroke|Peripheral Arterial Disease|Genetic Predisposition to Disease
Interventions: GENETIC: Exposure to genetics (polygenic)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Three Different Therapy Regimens in Treating Patients With Previously Untreated Hodgkin Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: bleomycin sulfate|DRUG: ABVD regimen|DRUG: carmustine|DRUG: cisplatin|DRUG: cytarabine|DRUG: dacarbazine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: gemcitabine hydrochloride|DRUG: ifosfamide|DRUG: melphalan|DRUG: methylprednisolone|DRUG: mitoguazone|DRUG: vincristine sulfate|DRUG: vindesine|DRUG: vinorelbine tartrate|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear Palsy
Status: UNKNOWN
Conditions: PSP - Progressive Supranuclear Palsy|PD - Parkinson's Disease|AD - Alzheimer's Disease|ALS (Amyotrophic Lateral Sclerosis)
Interventions: DIAGNOSTIC_TEST: Pupillometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acupuncture as a Complementary Treatment for Hypertension (ACT-HAS)
Status: UNKNOWN
Conditions: Hypertensive Disease
Interventions: OTHER: Laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity of a Surface Antigen, Inactivated Influenza Vaccine Formulation 2007-2008
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Surface antigen inactivated influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Early Closure Versus Conventional Closure in Postoperative Patients With Low Anteriresection for Rectal Cancer
Status: TERMINATED
Conditions: Colonic Neoplasms|Ileostomy - Stoma|Colorectal Surgery
Interventions: PROCEDURE: early ileostomy closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole in Preventing Breast Cancer in Healthy Postmenopausal Women at High Risk for Breast Cancer
Status: COMPLETED
Conditions: Healthy, no Evidence of Disease|Lobular Breast Carcinoma in Situ
Interventions: DRUG: letrozole|OTHER: quality-of-life assessment|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of ERCC and/or PEEP-ZEEP Maneuver on Oxygenation, Ventilation, and Airway Secretions Removal in MV Patients
Status: NOT_YET_RECRUITING
Conditions: Mechanically Ventilated Patients
Interventions: OTHER: Expiratory Rib Cage Compression|OTHER: PEEP-ZEEP Maneuver|OTHER: ERCC + PEEP-ZEEP maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Hepatocellular Cancer|Hepatitis B|Cirrhosis|Liver Cancer
Interventions: DEVICE: Study CT/MRI Imaging|DEVICE: Standard of Care CT/MRI Imaging|DIAGNOSTIC_TEST: Oncoguard™ Liver Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)
Status: RECRUITING
Conditions: Endovascular Thrombectomy|Large Vessel Occlusion|Acute Ischemic Stroke
Interventions: PROCEDURE: Mechanical Thrombectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Oncolytic Virus in Combination With HX-008 and Radiotherapy in Melanoma Patients With Liver Metastasis
Status: UNKNOWN
Conditions: Melanoma Stage IV
Interventions: DRUG: Recombinant Oncolytic HSV-2 Therapeutic Injecta (Vero Cell) for Human Use (rHSV2hGM-CSF)|DRUG: Recombinant humanized anti-PD-1 monoclonal antibody for injection|RADIATION: RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Research on the Efficacy of Thread-embedding Acupuncture on Herniated Intervertebral Disc of Lumbar Spine
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: PROCEDURE: Thread-embedding Acupuncture (TEA)|PROCEDURE: Sham Thread-embedding Acupuncture (STEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COMPARATIVE EVALUATION OF DIRECT PULP CAPPING AND COMPLETE PULPOTOMY IN MATURE PERMANENT MANDIBULAR MOLARS WITH CLINICAL SIGNS INDICATIVE OF MODERATE PULPITIS
Status: RECRUITING
Conditions: Moderate Pulpitis
Interventions: PROCEDURE: Direct pulp capping|PROCEDURE: Complete Pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Digital Technology-Supported Education on Patients Undergoing Breast Reconstruction After Mastectomy: A Randomized Controlled Study
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: digital technology-supported education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults
Status: COMPLETED
Conditions: Malaria|Malaria,Falciparum
Interventions: BIOLOGICAL: PfSPZ Vaccine|OTHER: Normal Saline Placebo|BIOLOGICAL: PfSPZ Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: UNAIR Inactivated COVID-19 Vaccine INAVAC as Heterologue Booster (Immunobridging Study) in Adolescent Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19 Pandemic|COVID-19 Vaccines
Interventions: BIOLOGICAL: INAVAC (Vaksin Merah Putih - UA- SARS CoV-2 (Vero Cell Inactivated) 5 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (Pilot)
Status: TERMINATED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Proxalutamide Therapy in Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Proxalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sodium Creatine Phosphate in Heart Valve Surgery
Status: UNKNOWN
Conditions: Heart Valve Diseases
Interventions: DRUG: sodium creatine phosphate|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE