pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Atropin and Glucose Stimulated Insulinsecretion and the Cephalic Insulin Response
Status: UNKNOWN
Conditions: The Focus of This Study is to Evaluete the Significances of the Vagal Cholinerg Nervuos System for the Effect of GLP-1 by Using Atropin Administration.
Interventions: DRUG: Atropine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ganitumab in Locally Advanced Unresectable Adenocarcinoma of the Pancreas
Status: TERMINATED
Conditions: Adenocarcinoma of the Pancreas|Locally Advanced|Unresectable
Interventions: DRUG: Gemcitabine|DRUG: AMG 479|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effect of AZD3199 on the Electrical Activity in the Heart
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Lung Disease
Interventions: DRUG: AZD3199|DRUG: Moxifloxacin|OTHER: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Immunogenicity Study of V503 (GARDASIL™9, 9vHPV Vaccine) Administered to 9- to 26-Year-Old Females and Males in Vietnam (V503-017)
Status: COMPLETED
Conditions: Papillomavirus Infections|Uterine Cervical Neoplasms|Vulvar Neoplasms|Vaginal Neoplasms|Adenocarcinoma in Situ|Condylomata Acuminata
Interventions: BIOLOGICAL: 9vHPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: DNAzyme targeting EBV-LMP1 (DZ1)|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Carboplatin in Treating Patients With Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: carboplatin|DRUG: docetaxel|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Sertraline 100 mg Tablet and ZOLOFT Following a 100 mg Dose in Healthy Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sertraline|DRUG: Sertraline Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Effect of Encapsulated vs Free Probiotic on Brain Function
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Maltodextrin|DIETARY_SUPPLEMENT: Encapsulated Lactocaseibacillus rhamnosus|DIETARY_SUPPLEMENT: Non-encapsulated Lactocaseibacillus rhamnosus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cortical Ischemic Stroke and Serotonin
Status: UNKNOWN
Conditions: Stroke
Interventions: DRUG: Serotonin Uptake Inhibitors|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose-response Study of Lidocaine and Etomidate
Status: COMPLETED
Conditions: Etomidate Overdose of Undetermined Intent
Interventions: DRUG: Lidocaine 1mg/kg|DRUG: Lidocaine 1.5mg/kg|DRUG: Lidocaine 2mg/kg|DRUG: Lidocaine 2.5mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004, KEYVIBE-004)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematological Malignancies
Interventions: BIOLOGICAL: Pembrolizumab/vibostolimab coformuation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol Versus D-chiro-inositol in the Treatment of Polycystic Ovary Syndrome and Insulin Resistance: Evaluation of Clinical, Metabolic, Endocrine and Ultrasound Parameters
Status: COMPLETED
Conditions: PCOS
Interventions: DIETARY_SUPPLEMENT: Myo-inositol + Folic acid|DIETARY_SUPPLEMENT: Myo-inositol + Folic acid|DIETARY_SUPPLEMENT: D-chiro-inositol, manganese, folic acid, vit B12|DIETARY_SUPPLEMENT: D-chiro-inositol, manganese, folic acid, vit B12|DRUG: Folic acid, vit B12|DRUG: Folic acid, vit B12
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: The Open Kinetic Chain and Closed Kinetic Chain Strengthening Exercises in Degenerative Meniscus Tears
Status: RECRUITING
Conditions: Degenerative Disease|Meniscus Tear|Knee Pain Swelling
Interventions: OTHER: Open kinetic chain strengthening exercise|OTHER: Closed kinetic chain strengthening exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vax Facts Human Papillomavirus (HPV): Study of a Computer-based Tailoring System and Mothers' Intentions to Vaccinate Their Daughters Against HPV
Status: COMPLETED
Conditions: Human Papillomavirus|Prevention
Interventions: BEHAVIORAL: Computer-based tailoring system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: SFX-01 After Subarachnoid Haemorrhage
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage, Spontaneous
Interventions: DRUG: SFX-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Bindarit in Preventing Stent Restenosis
Status: COMPLETED
Conditions: Coronary Restenosis
Interventions: DRUG: bindarit|DRUG: bindarit|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Pre-op Patient Education on Functional Outcomes After TKA
Status: COMPLETED
Conditions: Knee Arthropathy
Interventions: OTHER: Pre-operative education|OTHER: Pos-operative rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Focal MR-Guided Focused Ultrasound Treatment of Localized Intermediate Risk Prostate Lesions
Status: UNKNOWN
Conditions: Localized Intermediate Risk Prostate Lesions
Interventions: DEVICE: ExAblate MR Guided Focused Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Spinal Decompression of Metastatic Spinal Cord Compression, Minimal Access Versus Open Surgery
Status: COMPLETED
Conditions: Spinal Metastases
Interventions: PROCEDURE: open surgery|PROCEDURE: Minimal access surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 10 Year Follow up of RCT Comparing Different Regenerative Regenerative Procedures
Status: COMPLETED
Conditions: Periodontitis
Interventions: PROCEDURE: Modified minimally invasive surgery|PROCEDURE: Modified minimally invasive surgery with enamel matrix derivative|PROCEDURE: Modified minimally invasive surgery with enamel matrix derivative and bone replacement graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)
Status: TERMINATED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: DCS|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SYNB1618 and SYNB1934 in Adult Patients With Phenylketonuria
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: SYNB1618|DRUG: SYNB1934
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Infliximab on Insulin Sensitivity and Beta Cell Function in Insulin Resistant Human Obesity
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Metabolic Syndrome
Interventions: BIOLOGICAL: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Vitamin D Improve Glycemic Control in Type II DM?
Status: TERMINATED
Conditions: Diabetes Mellitus|Vitamin D Deficiency
Interventions: DRUG: vitamin D3 2000 IU|DRUG: vitamin D3 5000 IU|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Negative Pressure Wound Therapy to Standard Gauze Dressings for Acute Wounds in a Limited-Resource Setting
Status: WITHDRAWN
Conditions: Wounds and Injuries
Interventions: OTHER: Standard Gauze Dressing|DEVICE: WiCare NPWT dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Juvéderm® VOLUMA XC Injectable Gel for Cheek Augmentation
Status: COMPLETED
Conditions: Mid-facial Volume Deficit Related to Aging
Interventions: DEVICE: Juvéderm® VOLUMA XC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Investigation on the Benefits of Avoiding Conventional Food Packaging and Promoting Bioplastic Food Packaging
Status: COMPLETED
Conditions: Dietary Exposure
Interventions: BEHAVIORAL: Use of bio-plastic food packaging material and avoidance of plastic food packaging material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug-Drug Interaction Study of Lorecivivint and Triamcinolone Acetonide in Healthy Volunteers
Status: COMPLETED
Conditions: Drug-Drug Interaction
Interventions: DRUG: Lorecivivint (LOR)|DRUG: Triamcinolone acetonide (TA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Learn More About How the Study Treatment Elinzanetant (or BAY3427080) Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body After Taking Single and Multiple Doses in Healthy Women Aged 40 to 65 Years
Status: COMPLETED
Conditions: Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men|Hot Flashes|Healthy Volunteers
Interventions: DRUG: Elinzanetant (BAY3427080)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU)
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: PROCEDURE: Ultrasound group|PROCEDURE: Surgical group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis
Status: COMPLETED
Conditions: Pulpitis
Interventions: PROCEDURE: Partial endodontic treatment under local and/or locoregional anesthesia|DRUG: prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clostridium Histolyticum Collagenase Injection for Urethral Disease
Status: COMPLETED
Conditions: Urethral Stricture
Interventions: DRUG: Clostridium Histolyticum Collagenase|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of ABT-436 in Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: ABT-436|DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children
Status: COMPLETED
Conditions: Malaria, Cerebral
Interventions: DRUG: inhaled nitric oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Rehabilitation Exercise Program for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis
Interventions: OTHER: Exercise|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triple-site Biventricular Stimulation in the Optimization of CRT
Status: COMPLETED
Conditions: Heart Failure
Interventions: DEVICE: triple-site biventricular pacing with peri-operative echo guidance|DEVICE: standard biventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis
Status: UNKNOWN
Conditions: Dilated Cardiomyopathy
Interventions: PROCEDURE: cardiobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Welch Emotional Connection Screen (WECS) in the NICU
Status: UNKNOWN
Conditions: Premature Birth|Obstetric Labor, Premature
Interventions: BEHAVIORAL: Welch Emotional Connection Screen for Neonatal Intensive Care Unit|OTHER: NICU WECS Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Groningen International Study on Sentinel Nodes in Vulvar Cancer-III
Status: RECRUITING
Conditions: Vulvar Cancer|Sentinel Lymph Node|Lymph Node Metastases
Interventions: RADIATION: Radiotherapy combined with cisplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect on Tumor Perfusion of a Chemotherapy Combining Gemcitabine and Nab-paclitaxel (Abraxane) in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma Resectable|Pancreatic Adenocarcinoma Locally Advanced|Pancreatic Adenocarcinoma Metastatic
Interventions: DRUG: Gemcitabine|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Pegylated Interferon (PEG-IFN) Alfa-2a in HIV Infected People
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Pegylated interferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tofacitinib Versus Methotrexate as the First Line DMARD in the Treatment of Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methotrexate|DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Kudzu Effects on Brain Ethanol Levels: Proton Spectroscopy Assessment
Status: WITHDRAWN
Conditions: Alcohol Consumption|Cerebral Blood Flow
Interventions: DIETARY_SUPPLEMENT: Kudzu extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Tezepelumab (AMG 157) in Healthy Adults and Adults With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis|Healthy Volunteers
Interventions: DRUG: Tezepelumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Irbesartan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intracapsular Tonsillectomy in Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Tonsil Disease|Tonsillitis|Tonsillitis Acute|Tonsillitis Chronic
Interventions: PROCEDURE: tonsillectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Mesenchymal Stem Cells for Patients With Autoimmune Hepatitis
Status: UNKNOWN
Conditions: Autoimmune Hepatitis
Interventions: OTHER: conventional plus UC-MSC treatment|OTHER: Conventional plus placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Halofuginone Hydrobromide in Treating Patients With HIV-Related Kaposi's Sarcoma
Status: COMPLETED
Conditions: AIDS-related Kaposi Sarcoma|Recurrent Kaposi Sarcoma
Interventions: DRUG: halofuginone hydrobromide|OTHER: placebo|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Expressive Writing for Reducing Stress and Diabetic Symptoms in Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus|Stress|Depression
Interventions: BEHAVIORAL: Expressive writing|BEHAVIORAL: Neutral writing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies
Status: RECRUITING
Conditions: CNS Tumor|Solid Tumor
Interventions: DRUG: Nivolumab and Entinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Basic and Clinical Research on Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: OROS methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Intention In Aphasia: Neuroplastic Substrates
Status: COMPLETED
Conditions: Aphasia|Cerebrovascular Accident
Interventions: BEHAVIORAL: Word-finding with intention component|BEHAVIORAL: Word-finding with no intention component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study to Evaluate the Effect of Nitric Oxide on the Treatment of Tinea Pedis (Athlete's Foot)
Status: COMPLETED
Conditions: Tinea
Interventions: DRUG: Nitric Oxide|DRUG: Nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation|Delirium|Thiamine Deficiency
Interventions: DRUG: Thiamine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exploratory Study of Coronary Flow Reserve Measurements, a Non-Invasive Method for Coronary Function Measurements
Status: COMPLETED
Conditions: Atherosclerosis|Inflammatory Activity in Coronary Arteries
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Study in Patients With Advanced Solid Malignancies to Evaluate the Safety of ATOR-1017
Status: COMPLETED
Conditions: Solid Tumor|Neoplasms
Interventions: BIOLOGICAL: ATOR-1017
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Method JaPer. A New Strategy to Improve Inspirational Capacity
Status: COMPLETED
Conditions: Inspiratory Capacity
Interventions: OTHER: Respiratory muscle training 1 (Experimental Group)|OTHER: Respiratory muscle training 2 (Control Group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Alegitazar in Patients With Type 2 Diabetes And Chronic Kidney Disease (Alerenal Study)
Status: WITHDRAWN
Conditions: Diabetes Mellitus Type 2, Kidney Disease, Chronic
Interventions: DRUG: Aleglitazar|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Status: RECRUITING
Conditions: Primary Generalized Tonic-Clonic Seizures
Interventions: DRUG: XEN1101|DRUG: Placebo|DRUG: XEN1101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II - Brentuximab/5-Azacytidine in Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: Brentuximab Vedotin|DRUG: 5-Azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Using CR and PS Prosthesis in Total Knee Replacement
Status: UNKNOWN
Conditions: Total Knee Arthroplasty
Interventions: DEVICE: Cruciate-retaining (CR) prostheses|DEVICE: Posterior-stabilized (PS) prostheses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on All-Trans Retinoic Acid, Induction and Consolidation Therapy, and Pegfilgrastim After Consolidation Therapy in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Idarubicin|DRUG: Etoposide|DRUG: All-trans retinoic acid|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Platinum-Refractory Head and Neck Cancers
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of the Head and Neck
Interventions: BIOLOGICAL: REOLYSIN|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety Study of GSK Biologicals' Meningococcal Vaccine GSK 134612 Versus Menactra® in Healthy Adolescents/Adults
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal vaccine GSK 134612|BIOLOGICAL: Menactra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination of Dasatinib and Peg-Interferon Alpha 2b in First Line for Chronic Myeloid Leukemia in Chronic Phase
Status: COMPLETED
Conditions: Chronic Phase of Chronic Myeloid Leukemia
Interventions: DRUG: Dasatinib|DRUG: Peg-Interferon alpha2b
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Study of ACY-241 Alone and in Combination With Pomalidomide and Dexamethasone in Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: ACY-241|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 6 Week Study of MG01CI 1400 mg Compared With Placebo in Adults With ADHD ( Attention Deficit/Hyperactivity )
Status: COMPLETED
Conditions: ADHD|Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Interventions: DRUG: MG01CI (1400 mg)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Formal Versus Informal Mindfulness Among University Students With Self-reported ADHD, Nonsuicidal Self-injury, or Stress
Status: RECRUITING
Conditions: Nonsuicidal Self-injury|ADHD|Mindfulness
Interventions: BEHAVIORAL: Formal mindfulness instruction|BEHAVIORAL: Informal mindfulness instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post Myocardial Infarction's Rehabilitation Guided by Heart Rate Variability
Status: COMPLETED
Conditions: Myocardial Infarction|Cardiac Rehabilitation
Interventions: OTHER: HRV measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of an Oral Nutritional Supplement in Older Hospitalized Patients - NOURISH Study
Status: COMPLETED
Conditions: Hospitalized Elderly
Interventions: OTHER: Ready to Drink Flavored Beverage|OTHER: Ready to drink flavored beverage w/ AN 777
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Erythropoietin in the Treatment of Scleral Necrosis
Status: UNKNOWN
Conditions: Conjunctival and Scleral Avascular Lesions
Interventions: DRUG: Prescription of placebo|DRUG: Erythropoietin prescription|DRUG: Erythropoietin prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Study of AK104 and AK117 in Combination With or Without Chemotherapy in Advanced Malignant Tumors
Status: UNKNOWN
Conditions: Advanced Malignant Tumors
Interventions: DRUG: AK104|DRUG: AK117|DRUG: Capecitabine tablets|DRUG: Oxaliplatin|DRUG: Cisplatin|DRUG: Paclitaxel|DRUG: Irinotecan|DRUG: Docetaxel|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunologic Action of a Single Dose Cholecalciferol
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: single administration of 100.000 I.U. vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy and Safety Study of Omega-3 Free Fatty Acids (Epanova™) for the Maintenance of Symptomatic Remission in Subjects With Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Epanova™ (Omega-3 Free Fatty Acids)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Ability of HT-6184 to Reduce Inflammation and Pain After Third Molar Extraction
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: HT-6184|DRUG: HT-6184 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Host Genetic Factors in the Occurrence of Anemia and on the Virological Response to a Peg-interferon/Ribavirin Therapy in HIV-HCV Co-infected Patients
Status: COMPLETED
Conditions: HIV-HCV Co-infected Patients
Interventions: GENETIC: blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Squamous Cell Carcinoma of Anal Canal|Colorectal Cancer|Squamous Cell Carcinoma of the Lung|EGFR Amplification|Epithelial Ovarian Cancer|Pancreas Cancer|Cutaneous Squamous Cell Carcinoma|Head and Neck Neoplasms|Carcinoma, Squamous Cell|Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: BCA101|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strengthening Contraceptive Counseling Services: Research Protocol for a Multi-phase Complex Intervention in Pakistan and Nigeria
Status: NOT_YET_RECRUITING
Conditions: Contraception|Empowerment|Decision Making
Interventions: OTHER: Contraceptive counseling strengthening intervention package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MR Antagonist and LSD1
Status: RECRUITING
Conditions: Hypertension|Mineralocorticoid Excess
Interventions: DRUG: Eplerenone|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study Comparing Morbidity and Quality of Life Associated in the Treatment by Surgical Resection and the Conservative Treatment, After Favorable Evolution of Purulent Peritonitis That Originates From Diverticulitis Treated by Mini-invasive Surgery
Status: UNKNOWN
Conditions: Peritonitis|Diverticulitis
Interventions: PROCEDURE: Surgical reserction|OTHER: Radiological percutaneous drainage and washing drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) With or Without Opioids
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Remifentanil|DRUG: Fentanyl|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy With Trastuzumab and Chemotherapy and the Resultant Pathologic Complete Response Observed in HER2 Positive Breast Cancer;a Systematic Review
Status: COMPLETED
Conditions: HER2+ Breast Cancer
Interventions: DRUG: Trastuzumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prehabilitation to Revolutionize Oncology: Telehealth Exercise for Cognitive Triumphs (The PROTECT Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Cancer of the Breast
Interventions: OTHER: Physical Activity Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of Nitric Oxide for Inhalation on Chronic Lung Disease in Premature Babies
Status: COMPLETED
Conditions: Lung Disease
Interventions: DRUG: Nitric oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant PDT in the Treatment of Cholangiocarcinoma
Status: NOT_YET_RECRUITING
Conditions: Cholangiocarcinoma Resectable
Interventions: PROCEDURE: Neoadjuvant PDT + radical surgery|PROCEDURE: Radical surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of LiRIS® in Females With Interstitial Cystitis With Hunner's Lesions
Status: COMPLETED
Conditions: Cystitis, Interstitial|Ulcer
Interventions: DRUG: LiRIS®|DRUG: LiRIS Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Rett Syndrome With Recombinant Human IGF-1
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: DRUG: Recombinant Human Insulin Growth Factor 1 (rhIGF-1)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes
Status: TERMINATED
Conditions: Cardiovascular Disease
Interventions: DRUG: Rimonabant|DRUG: Placebo (for Rimonabant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Supradyn® Energy 3RDA on Fatigue/Stress, Substrate Metabolism During Exercise and Demanding Cognitive Tasks
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Supradyn® Energy 3RDA|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evolocumab in Patients With Acute MI
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Evolocumab|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasm|Squamous Cell Carcinoma
Interventions: DRUG: paclitaxel concurrent with radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Collecting Tumor Samples From Patients With Gynecological Tumors
Status: COMPLETED
Conditions: Borderline Ovarian Clear Cell Tumor|Borderline Ovarian Serous Tumor|Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Small Cell Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Childhood Embryonal Rhabdomyosarcoma|Childhood Malignant Ovarian Germ Cell Tumor|Endometrioid Stromal Sarcoma|Gestational Trophoblastic Tumor|Malignant Mesothelioma|Malignant Ovarian Epithelial Tumor|Melanoma|Neoplasm of Uncertain Malignant Potential|Ovarian Brenner Tumor|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Paget Disease of the Vulva|Recurrent Cervical Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Ovarian Germ Cell Tumor|Recurrent Primary Peritoneal Carcinoma|Recurrent Uterine Corpus Carcinoma|Recurrent Vaginal Carcinoma|Recurrent Vulvar Carcinoma|Stage I Ovarian Cancer|Stage I Uterine Corpus Cancer|Stage I Vaginal Cancer|Stage I Vulvar Cancer|Stage IA Cervical Cancer|Stage IA Fallopian Tube Cancer|Stage IA Ovarian Cancer|Stage IA Ovarian Germ Cell Tumor|Stage IB Cervical Cancer|Stage IB Fallopian Tube Cancer|Stage IB Ovarian Cancer|Stage IB Ovarian Germ Cell Tumor|Stage IC Fallopian Tube Cancer|Stage IC Ovarian Cancer|Stage IC Ovarian Germ Cell Tumor|Stage II Ovarian Cancer|Stage II Uterine Corpus Cancer|Stage II Vaginal Cancer|Stage II Vulvar Cancer|Stage IIA Cervical Cancer|Stage IIA Fallopian Tube Cancer|Stage IIA Ovarian Cancer|Stage IIA Ovarian Germ Cell Tumor|Stage IIB Cervical Cancer|Stage IIB Fallopian Tube Cancer|Stage IIB Ovarian Cancer|Stage IIB Ovarian Germ Cell Tumor|Stage IIC Fallopian Tube Cancer|Stage IIC Ovarian Cancer|Stage IIC Ovarian Germ Cell Tumor|Stage III Borderline Ovarian Surface Epithelial-Stromal Tumor|Stage III Cervical Cancer|Stage III Uterine Corpus Cancer|Stage III Vaginal Cancer|Stage III Vulvar Cancer|Stage IIIA Fallopian Tube Cancer|Stage IIIA Ovarian Cancer|Stage IIIA Ovarian Germ Cell Tumor|Stage IIIA Primary Peritoneal Cancer|Stage IIIB Fallopian Tube Cancer|Stage IIIB Ovarian Cancer|Stage IIIB Ovarian Germ Cell Tumor|Stage IIIB Primary Peritoneal Cancer|Stage IIIC Fallopian Tube Cancer|Stage IIIC Ovarian Cancer|Stage IIIC Ovarian Germ Cell Tumor|Stage IIIC Primary Peritoneal Cancer|Stage IV Borderline Ovarian Surface Epithelial-Stromal Tumor|Stage IV Fallopian Tube Cancer|Stage IV Ovarian Cancer|Stage IV Primary Peritoneal Cancer|Stage IV Uterine Corpus Cancer|Stage IVA Cervical Cancer|Stage IVA Vaginal Cancer|Stage IVB Cervical Cancer|Stage IVB Vaginal Cancer|Stage IVB Vulvar Cancer|Uterine Corpus Cancer|Uterine Corpus Leiomyosarcoma|Vulvar Squamous Cell Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Panitumumab-IRDye800 Compared to Sentinel Node Biopsy and (Selective) Neck Dissection in Identifying Metastatic Lymph Nodes in Patients With Head&Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Squamous Cell Carcinoma of the Head and Neck (SCCHN)|Head and Neck Cancer
Interventions: DRUG: Panitumumab-IRDye800|DRUG: Lymphoseek
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network
Status: COMPLETED
Conditions: Vaginitis
Interventions: DRUG: Terazol or oral fluconazole for candidal vaginitis|DRUG: Metronidazole or Clindamycin for Bacterial Vaginosis|DRUG: Flagyl for definitively diagnosed vaginal trichomoniasis|OTHER: Empiric Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine in Simultaneous Bilateral Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Pain
Interventions: DRUG: Liposomal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Postpartum Integration of Vaccines and Contraception Trial
Status: RECRUITING
Conditions: Contraception|Gender Equity
Interventions: OTHER: Postpartum Integration of Vaccines and Contraception Through Gender-Transformative Programming(PIVoT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: BN-Brachyury, Entinostat, Adotrastuzumab Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT)
Status: TERMINATED
Conditions: Breast Cancer|Triple Negative Breast Cancer|HER2+ Breast Cancer|Hormone Receptor Negative Breast Cancer|Metastatic Breast Cancer
Interventions: BIOLOGICAL: Brachyury-TRICOM|DRUG: Entinostat|BIOLOGICAL: M7824|BIOLOGICAL: Ado-trastuzumab emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of a Novel Dietary Microalgae Based Ingredient on Muscle Recovery and Endurance Capacity
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: MicAlgae|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of 4 Prime-boost Combinations of HIV Vaccine Candidates in Healthy Volunteers
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: LIPO-5|BIOLOGICAL: MVA HIV-B (MVATG17401)|BIOLOGICAL: GTU®-MultiHIV B: 0.5 mL IM via Biojector® 2000 and 0.5mL IntraDermic, 3 shots
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study To Determine The Maximum Range of Light Doses At Two HPPH Doses With Acceptable Normal Tissue Toxicity For PDT Treatment Of High Grade Dysplasia,CIS or Early Adenocarcinoma In Barrett's Esophagus
Status: COMPLETED
Conditions: Barrett's Esophagus|CIS|HGD
Interventions: DRUG: HPPH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: App-technology to Improve Healthy Lifestyle Behaviors Among Working Adults
Status: COMPLETED
Conditions: Lifestyle|Quality of Life|mHealth|Mobile Applications|Adults
Interventions: BEHAVIORAL: App-technology and active coaching to improve lifestyles behaviors|BEHAVIORAL: App-technology to improve lifestyle behaviors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Survival Observational Study in Patients With Advanced IIIB-IV Squamous Cell Lung Cancer Receiving PD-1 Combination With Chemotherapy
Status: UNKNOWN
Conditions: Lung Squamous Cell Carcinoma Stage IV
Interventions: DRUG: Nivolumab or Pembrolizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients
Status: COMPLETED
Conditions: Opioid Dependence|Buprenorphine Withdrawal Syndrome
Interventions: DRUG: Lofexidine HCl|DRUG: Lofexidine-matching sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Stem Cell Transplantation in Treating Patients With Stage IIIB Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: melphalan|DRUG: mesna|DRUG: paclitaxel|DRUG: tamoxifen citrate|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 4 Week Study of the Safety, Tolerability, and Pharmacodynamics of ShK-186 (Dalazatide) in Active Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: dalazatide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Trial of ARV-110 and Abiraterone in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: ARV-110 in Combination with Abiraterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Eight-week Study Evaluating the Efficacy of a 100mg Dose of Saredutant Once Daily, in Elderly Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: saredutant (SR48968)|DRUG: placebo|DRUG: escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robot-Assisted Ultrasound for Thermal Ablative Therapy in Treating Patients With Small Kidney Masses Undergoing Surgery
Status: WITHDRAWN
Conditions: Renal Carcinoma|Renal Mass
Interventions: PROCEDURE: Robot-Assisted Laparoscopic Surgery|PROCEDURE: High-Intensity Focused Ultrasound Ablation|PROCEDURE: Therapeutic Laparoscopic Surgery|DEVICE: Sonatherm 600i Ultrasonic Lesion Generating System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack.
Status: COMPLETED
Conditions: Acute Myocardial Infarction|Heart Failure
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Between Two Tramadol Formulations: Study of the Better Controlled Release of a New 200 mg Once A Day (OAD) Formulation Versus Zytram® 200 mg
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Tramadol Contramid OAD|DRUG: Zytram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT