pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Interactive Physical and Cognitive Exercise System
Status: UNKNOWN
Conditions: Alzheimer Disease, Early Onset|MCI|Aging|Mild Cognitive Impairment|Neurocognitive Disorder|Cognitive Impairment|Cognitive Change
Interventions: BEHAVIORAL: physical exercise alone (PES) first|DEVICE: cognitive exercise alone (iCE) first|DEVICE: interactive Physical and Cognitive Exercise (iPACES™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Adult Patients With Nonalcoholic Steatohepatitis Who Also Have Type 2 Diabetes
Status: WITHDRAWN
Conditions: Nonalcoholic Steatohepatitis|Type 2 Diabetes Mellitus
Interventions: DRUG: TEV-45478|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of VBY-036 in Healthy Volunteers After 7 Days of Oral Dosing
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: VBY-036
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensity-Modulated Radiation Therapy With Incorporated Boost and Capecitabine Before Surgery in Treating Patients With Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phase 3b Study of Metvix NDL-PDT Versus Metvix c-PDT in Subjects With Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: NDL-PDT|DRUG: c-PDT|DRUG: placebo c-PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Control of Iatrogenic Endobronchial Bleeding by Tranexamic Acid, Adrenalin and Hemagglutinase
Status: RECRUITING
Conditions: Iatrogenic Endobronchial Bleeding
Interventions: DRUG: Tranexamic Acid；|DRUG: Adrenalin|DRUG: Hemagglutinase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: COGNUTRIN in Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: VitaBlue™|OTHER: Placebo|DRUG: Lovaza®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose-Ranging Study of the Efficacy of ABT-894 in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder|ADHD
Interventions: DRUG: ABT-894|DRUG: atomoxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interventricular Delay of Lumax HF-T for Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DEVICE: Optimized interventricular delay biventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Carbon Dioxide (CO2) Acupulse Laser Treatment on Urinary Stress Incontinence.
Status: COMPLETED
Conditions: Exposure Laser
Interventions: DEVICE: CO2 AcuPulse Laser|DEVICE: Sham Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Danish Precocious Puberty Study - DAPP Study A National Cohort Study on Incidence and Etiologies for Precocious Puberty
Status: NOT_YET_RECRUITING
Conditions: Puberty, Precocious
Interventions: DRUG: Metformin Hydrochloride tablet|DRUG: Placebo|BEHAVIORAL: Lifestyle intervention|BEHAVIORAL: No lifestyle intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Status: RECRUITING
Conditions: Asthma
Interventions: BIOLOGICAL: Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of an Active Geriatric Evaluation for Geriatric Syndromes to Prevent Functional Decline in Family Medicine
Status: COMPLETED
Conditions: Geriatric Syndrome|Functional Ability
Interventions: OTHER: Active Geriatric Evaluation (AGE tool)|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Crestal Bone Level After Allogenic Bone Ring With Simultaneous Dental Implant Placement
Status: UNKNOWN
Conditions: Allogenic Bone Ring
Interventions: PROCEDURE: allogenic bone ring|PROCEDURE: autogenous bone ring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TPI 287 Administered Every 21 Days in Patients With Advanced Malignancies
Status: COMPLETED
Conditions: Neoplasms|Hodgkin's Disease|Non-Hodgkin's Lymphoma
Interventions: DRUG: TPI 287 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Expanded Safety Study of Dapivirine Gel 4759 in Africa
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome
Interventions: DRUG: dapivirine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated Syndrome
Status: RECRUITING
Conditions: Clinically Isolated Syndrome|Radiologically Isolated Syndrome|Multiple Sclerosis in Children
Interventions: DIAGNOSTIC_TEST: Tear collection and lumbar punction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands
Status: TERMINATED
Conditions: Malaria|Malaria in Pregnancy
Interventions: DRUG: Sulphadoxine-pyrimethamine|DRUG: Chloroquine prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anti-pseudomonas IgY to Prevent Infections in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Infection|Pseudomonas Aeruginosa
Interventions: DRUG: Anti-pseudomonas IgY gargle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Pharmacodynamics, Pharmacokinetics and Safety of a Single Oral Repeated Dose of 500 mg Nicotinic Acid as Tablets in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Nicotinic Acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transabdominal Versus Transvaginal Ultrasound to Assess the Thickness of the Lower Uterine Segment.
Status: COMPLETED
Conditions: Trans Abdominal Ultrasound|Transvaginal Ultrasound|Lower Uterine Segment Thickness
Interventions: DIAGNOSTIC_TEST: transabdominal ultrasound and transvaginal ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of GFH312 in Patients With Peripheral Artery Disease (PAD) and Intermittent Claudication (IC)
Status: WITHDRAWN
Conditions: Intermittent Claudication|Peripheral Artery Disease
Interventions: DRUG: GFH312|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Injection of Ranibizumab Versus Sham Before Vitrectomy in Patients With Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Interventions: DRUG: ranibizumab|DRUG: sham|PROCEDURE: pars plana vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lateral Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Laparoscopic Surgery
Status: COMPLETED
Conditions: Abdominal Pain
Interventions: PROCEDURE: Ultrasound guided QL block|PROCEDURE: Ultrasound guided TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy & Safety of Quetiapine Fumarate (SEROQUEL) & Placebo in the Treatment of Acutely Ill Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Quetiapine Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Does Limb Pre-Conditioning Reduce Pain After Hip Arthroscopy
Status: COMPLETED
Conditions: Hip Injuries|Hip Dislocation|Hip Fractures
Interventions: DIAGNOSTIC_TEST: standardized pre-conditioning treatment|DIAGNOSTIC_TEST: Partial occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy of the myDIET Software Tool in the Nutritional Management of Patients With Localized and Resectable Gastric or Esogastric Junction Cancer.
Status: RECRUITING
Conditions: Gastric Cancer|Oesogastric Junction Cancer
Interventions: OTHER: myDIET software tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Finding Study of CHF 4226 for Treating Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: carmoterol (CHF 4226)|DRUG: carmoterol (CHF 4226)|DRUG: carmoterol (CHF 4226)|DRUG: salmeterol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Healthy Adolescents
Status: COMPLETED
Conditions: Meningitis|Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (Serogroups A, C, Y, and W135) Tetanus Toxoid Conjugate Vaccine|BIOLOGICAL: Meningococcal (Groups A, C, Y and W135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine|BIOLOGICAL: Adacel®: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed|BIOLOGICAL: GARDASIL®: Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant|BIOLOGICAL: Meningococcal Polysaccharide (Serogroups A, C, Y, and W135) Tetanus Toxoid Conjugate Vaccine|BIOLOGICAL: Adacel®: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed|BIOLOGICAL: GARDASIL®: Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study of Lidocaine Infusion During Bowel Cancer Surgery for Cancer Outcome
Status: RECRUITING
Conditions: Colorectal Cancer|Quality of Life|Recurrent Cancer
Interventions: DRUG: Lidocaine hydrochloride 2% for injection|DRUG: 0.9% sterile Sodium Chloride solution for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PF-06952229 Treatment in Adult Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Breast Neoplasms|Prostate Neoplasms|Neoplasms, Squamous Cell|Melanoma|Mesothelioma|Pancreatic Neoplasms|Colorectal Neoplasms|Carcinoma, Renal Cell|Liver Neoplasms
Interventions: DRUG: PF-06952229|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Niaspan™ on High-density Lipoprotein (HDL) in Healthy Male Subjects (0000-069)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: Niaspan|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Blue Light Emitting Diode Therapy on Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Recurrent Vulvovaginal Candidiasis
Interventions: DEVICE: Blue Light Emitting Diode Therapy|DRUG: Azole Antifungal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study Using Glaukos® Trabecular Micro-Bypass Stent Model GTS400 Using the G2-M-IS Injector System in Conjunction With Cataract Surgery
Status: COMPLETED
Conditions: Primary Open-angle Glaucoma
Interventions: DEVICE: iStent inject|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Relation Between Rectus Femoris Muscle Tension and Hamstring Strength and Activity in Healthy Sprinters
Status: UNKNOWN
Conditions: Muscle Stretching Exercise
Interventions: PROCEDURE: Rectus femoris stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Polycystic Liver Disease in Kidney Transplant
Status: TERMINATED
Conditions: Polycystic Liver Disease
Interventions: DRUG: Tacrolimus|DRUG: Sirolimus|DRUG: Mycophenolate Mofetil|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban in the Treatment of Venous Thromboembolism (VTE) in Cancer Patients
Status: TERMINATED
Conditions: Venous Thromboembolism|Cancer
Interventions: DRUG: Rivaroxaban|DRUG: low-molecular heparine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transforaminal Epidural Injection in Acute Sciatica
Status: RECRUITING
Conditions: Sciatica|Sciatica Due to Intervertebral Disc Disorder|Sciatic Radiculopathy
Interventions: DRUG: Lidocaine|DRUG: Methylprednisolone Acetate|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: GnRH agonist trigger|DRUG: hCG trigger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Topical Minocycline FXFM244 in Rosacea Patients
Status: TERMINATED
Conditions: Rosacea
Interventions: DRUG: Topical Minocycline Foam FXFM244
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Envarsus XR and Digital Health Technology in Reducing Tacrolimus Fluctuation and Frequency of Dose Changes
Status: WITHDRAWN
Conditions: Medication Adherence|Renal Transplant
Interventions: COMBINATION_PRODUCT: Conversion to Envarsus-XR and use of smart phone app, TransMedAx|DRUG: Convert to Envarsus XR once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of tDCS on Schizophrenia With Negative Symptoms
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Intravenous Acetaminophen in Pediatrics Undergoing Spinal Fusion Surgery
Status: COMPLETED
Conditions: Scoliosis; Adolescence
Interventions: DRUG: intravenous acetaminophen|DRUG: intravenous acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children
Status: UNKNOWN
Conditions: Small for Gestational Age
Interventions: DRUG: Metformin|DRUG: Growth Hormone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine vs. Midazolam Sedation for Endobronchial Ultrasound
Status: COMPLETED
Conditions: Conscious Sedation During Procedure|Endobronchial Ultrasound
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam bolus|OTHER: Saline placebo|DRUG: Rescue midazolam|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Second-generation CD19-CAR T Cells for Pediatric Relapsed/Refractory B-ALL
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: CD19-CAR_Lenti_ALLO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemoglobinopathy Nursing Program and Pediatric Nursing Students
Status: COMPLETED
Conditions: Hemoglobinopathies|Thalassemia|Sickle Cell Disease|Nurse's Role
Interventions: OTHER: Hemoglobinopathy Nursing Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: OnTrack>An Online Role-Playing Game for Young People With First Episode Psychosis
Status: COMPLETED
Conditions: Psychosis|Schizoaffective Disorder|Schizophrenia
Interventions: BEHAVIORAL: OnTrack>TheGame (OTG)|BEHAVIORAL: Recovery Videos (RV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cytoreductive Surgery(CRS) Plus Hyperthermic Intraoperative Peritoneal Chemotherapy(HIPC) With Cisplatin to Treat Peritoneal Carcinomatosis From Upper Gastrointestinal Cancer
Status: TERMINATED
Conditions: Peritoneal Carcinomatosis|Gastrointestinal Cancer
Interventions: PROCEDURE: Cytoreductive Surgery (CRS) plus Hyperthermic Intraoperative Peritoneal Chemotherapy with Cisplatin (HIPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Female External Genital Region: a Clinical Trial
Status: COMPLETED
Conditions: Dissatisfaction Appearance of the External Genitalia
Interventions: DEVICE: Radiofrequency|DEVICE: Radiofrequency - OFF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema
Status: TERMINATED
Conditions: Macular Edema, Diabetic
Interventions: DRUG: Ranibizumab|DRUG: Placebo|DRUG: PF-04634817|DRUG: Masked Sham Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Rapid Onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysregulation (ROHHAD )
Status: WITHDRAWN
Conditions: ROHHAD Syndrome
Interventions: DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomics and Pharmacometabolomics of Acamprosate Treatment Outcome
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Acamprosate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fluconazole on Pharmacokinetics of SHR2554 in Healthy Subjects
Status: COMPLETED
Conditions: Malignant Tumor
Interventions: DRUG: SHR2554 Tablets|DRUG: Fluconazole Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults
Status: COMPLETED
Conditions: Cognitive Impairment|Cognitive Decline|Cognition Disorders in Old Age|Well-Being, Psychological|Inflammation|Cognitive Fun
Interventions: DIETARY_SUPPLEMENT: LasoperinTM|DIETARY_SUPPLEMENT: Placeo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Efficiency Of The Methotrexate At Patients Affected By Grave Pelade
Status: COMPLETED
Conditions: ALOPECIA AREATA
Interventions: DRUG: Methotrexate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Xylitol-based Chewing Gums, Sugar-free and Sugared, on Salivary Flow and pH in Young Adults
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Gum of Xylitol|OTHER: Gum of sugar free|OTHER: Gum of sugar|OTHER: Paraffin wax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparing the Visual Outcome, Visual Quality, and Satisfaction Among Three Types of Multi-focal Intraocular Lenses
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Mix-and-Match|DEVICE: EDOF|DEVICE: Trifocal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations
Status: WITHDRAWN
Conditions: Asthma
Interventions: DEVICE: NIPPV (PALMtop PTV)|DEVICE: Volumetric CO2 (NM3)|DEVICE: USCOM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sufentanil and Ropivacaine
Status: COMPLETED
Conditions: Anesthesia Complications
Interventions: DRUG: 0.25 sufentanil|DRUG: 0.5µg/ml sufentanil|DRUG: 0.1% ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Effectiveness of Educational Intervention to Help Physicians Address Inappropriate Patient Requests for Direct-to-Consumer Advertised Prescription Medications
Status: COMPLETED
Conditions: Lumbosacral Muscle Strain
Interventions: OTHER: Web-based educational modules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose:
Clinical trial: A Study of Participant Satisfaction and Safety With Subcutaneously Administered Trastuzumab (Herceptin) in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel|DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Neo-adjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for Subjects With Relapsed/Refractory Non-Hodgkin Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Non-Hodgkin Lymphoma Refractory/ Relapsed
Interventions: BIOLOGICAL: CD19 t-haNK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Insulin Glargine 300 U/mL in Patients With Type 2 Diabetes Mellitus Uncontrolled on Other Kinds of Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: INSULIN GLARGINE (U300)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ropivacaine Plasma Concentrations After Fascial Blocks in Elective Cardio-thoracic and Abdominal Surgery
Status: RECRUITING
Conditions: Local Anesthetic Toxicity|Regional Anesthesia Morbidity|Postoperative Pain
Interventions: PROCEDURE: Fascial block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis
Status: TERMINATED
Conditions: Psoriasis|Metabolic Syndrome|Hyperlipidemia|Obesity|Hypertension
Interventions: DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bed Rest on the Effect of CSF Leakage Repair After Transsphenoidal Pituitary Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Adenoma Pituitary|CSF Leakage
Interventions: OTHER: Bed rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare and Evaluate the Efficacy and Safety Between TS-RF System and BRK Transseptal Needles Used for Transseptal Puncture for Left Atrial Access.
Status: RECRUITING
Conditions: Arrhythmias, Cardiac|Atrial Fibrillation|Heart Diseases
Interventions: DEVICE: TS-RF Transseptal Needle|DEVICE: BRK Transseptal Needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immune Benefits of WGP in Elderly
Status: COMPLETED
Conditions: Elderly People
Interventions: DIETARY_SUPPLEMENT: Food fibers|DIETARY_SUPPLEMENT: Maltodextrin|BIOLOGICAL: Influenza vaccine (incl. criterion)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance
Status: TERMINATED
Conditions: Impaired Mitochondrial Function, Muscle Performance
Interventions: DIETARY_SUPPLEMENT: Acipimox|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Desloratadine and Pseudoephedrine Extended-release Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Desloratadine and pseudoephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Intermittent Catheters and Occurrence of Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DEVICE: SpeediCath|DEVICE: Conveen Uncoated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Strength-resistance Training in Valvular Heart Disease Patients
Status: NOT_YET_RECRUITING
Conditions: Exercise Based Prehabilitation in Valvular Surgery
Interventions: OTHER: Exercise based prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analyzing Gait Parameters Among Women With and Without Stress Urinary Incontinence
Status: RECRUITING
Conditions: Gait|Stress Urinary Incontinence|Women
Interventions: OTHER: Incontinence Symptom Severity Index|OTHER: Force platform|OTHER: The STT three-dimensional motion analysis (3DMA) system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oracea Soolantra Association in Participants With Severe Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Ivermectin 1% cream|DRUG: Doxycycline 40 mg MR (30 mg Immediate Release & 10 mg Delayed Release beads) capsules|OTHER: Oral placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Cues for Gait Training Post-stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Usual care|BEHAVIORAL: Overground visual cue training|BEHAVIORAL: Treadmill visual cue training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Walking Exercises in Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Quality of Life|Symptoms and Signs
Interventions: BEHAVIORAL: walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Outpatient Hospitalization of Unaccompanied Patients at Home for Endovascular Treatment of Peripheral Arterial Disease.
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: OTHER: 24 months of inclusion of unaccompanied patients|OTHER: 18 months of inclusion of unaccompanied patients|OTHER: 12 months of inclusion of unaccompanied patients|OTHER: 6 months of inclusion of unaccompanied patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical and Radiographic Evaluation of Immediate Implant Placement Using Osseodensification Versus Traditional Drilling Protocol
Status: RECRUITING
Conditions: Implant Complication
Interventions: PROCEDURE: Conventional drilling|PROCEDURE: Osseodensification drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Allergic Rhinitis In Patients Who Also Have Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: fluticasone propionate/salmeterol (FSC)|DRUG: montelukast (MON)|DRUG: fluticasone propionate (FP)|DRUG: placebo nasal|DRUG: ADVAIR DISKUS|DRUG: placebo capsule|DRUG: placebo DISKUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Benzyl penicillin|DRUG: Gentamicin Sulfate|DRUG: Ceftriaxone|DRUG: Amoxicillin Clavulanate|OTHER: Intravenous fluid|OTHER: Nasogastric feeds|DRUG: Ampicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended Bolus for Meals in a Closed-loop System
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DRUG: Extended bolus of insulin then standard bolus of insulin|DRUG: Standard bolus of insulin then extended bolus of insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study of Oral Steroid Sulphatase Inhibitor BN83495 Versus Megestrol Acetate (MA) in Women With Advanced or Recurrent Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: BN83495|DRUG: Megestrol Acetate (MA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Spinal Epidural Urinary Retention
Status: TERMINATED
Conditions: Anesthesia|Pain|Urinary Retention
Interventions: DEVICE: Foley catheter|OTHER: No foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diagnostic Performance of the Vesical Imaging-Reporting and Data System (VI-RADS) in Detecting Muscle-invasive Bladder Tumour (MIBC) in Clinical Practice: Comparison With Transurethral Resection of Bladder Cancer (TURB) and Evaluation of Diagnostic Accuracy According to Tumour Location
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: PROCEDURE: VI-RADS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of Rasagiline in Levodopa-Treated Parkinson's Disease Patients With Motor Fluctuations
Status: COMPLETED
Conditions: Parkinson´s Disease
Interventions: DRUG: Rasagiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of PM01183 in Non-Colorectal Cancer Patients as a Days 1 and 8 Intravenous Short Infusion Every 3 Weeks
Status: COMPLETED
Conditions: Major Advanced Solid Tumors Other Than Colorectal
Interventions: DRUG: PM01183
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive Assessment of Trunk, Scapula and Upper Limb in Neurological Patients. Reliability, Validity and Interrelatedness
Status: COMPLETED
Conditions: Multiple Sclerosis|Stroke
Interventions: OTHER: Clinical Scapular protocol (ClinScaP)|OTHER: the prevalence of trunk, scapula and upper limb impairments.|OTHER: the interaction between trunk, scapula and upper limb impairments.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Absolute Bioavailability and ADME Study of [14C]AZD9977 in Healthy Male Subjects
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DRUG: AZD9977 capsule 50 mg|DRUG: [14C]AZD9977 Solution for Infusion, 20 µg/mL (NMT 37.0 kBq/5 mL)|DRUG: [14C]AZD9977 Oral Suspension, 100 mg (NMT 9.9 MBq)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ph 2 Maintenance Trial: Ixazomib vs Ixazomib-Lenalidomide for MM Patients
Status: TERMINATED
Conditions: Newly Diagnosed Multiple Myeloma
Interventions: DRUG: Ixazomib|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Frequency Used in Transcutaneous Electrical Nerve Stimulation (TENS) for Treating Pelvic Pain in Adults
Status: RECRUITING
Conditions: Chronic Pelvic Pain
Interventions: DEVICE: Compass Health TENS 3000, 3 mode Analog Unit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Strength Training in Chronic Kidney Disease
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Hypertension|Aging|Blood Pressure
Interventions: DEVICE: IMST|DEVICE: Sham Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Cisplatin in Treating Patients With Locally Advanced or Metastatic Penile Cancer
Status: COMPLETED
Conditions: Penile Cancer
Interventions: DRUG: cisplatin|DRUG: irinotecan hydrochloride|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Effects of the Desipramine on the Neurovegetative Parameters of the Child With Rett Syndrome
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: DRUG: Administration of a high dose of desipramine|DRUG: Administration of a low dose of desipramine|DRUG: Administration of a placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving the HIV PrEP Cascade Using an Intervention for Healthcare Providers
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: OTHER: PrEP Optimization Intervention (PrEP-OI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Coronary Covered Stents Implantation for the Treatment of Coronary Artery Perforation
Status: RECRUITING
Conditions: Coronary Artery Perforation
Interventions: DEVICE: the Coronary Covered Stents System manufactured by Shanghai MicroPort Medical (Group) Co., Ltd.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Mesorectum Excision With Left Colic Artery Preservation for the Treatment of Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: a high ligation of IMA|PROCEDURE: a low ligation of IMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Different Clinical Techniques to Treat Patients With Chronic Low Back Pain
Status: RECRUITING
Conditions: Chronic Low Back Pain (CLBP)
Interventions: DRUG: NSAIDs (Nonsteroidal Anti-Inflammatory Drugs):|PROCEDURE: Standard Physical Therapy|PROCEDURE: Neuromodulation via Dorsal Root Ganglion (DRG):|PROCEDURE: Platelet-Rich-Plasma Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of the Meaning-Making Intervention (MMi)
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: BEHAVIORAL: Meaning-Making intervention (MMi)|BEHAVIORAL: Empathic visitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Exploratory Study of Herombopag for Thrombocytopenia Induced by Chemotherapy Combined With Immunotherapy in NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: herombopag olamine tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Obstructive Cardiomyopathy, Hypertrophic|Non-obstructive Hypertrophic Cardiomyopathy
Interventions: DRUG: Sotagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketorolac on Posterior Thoracolumbar Spinal Fusions
Status: RECRUITING
Conditions: Thoracolumbar Spinal Fusions
Interventions: DRUG: Saline|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study: An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post- Essential Thrombocythemia Myelofibrosis Previously Treated With Ruxolitinib
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-Polycythemia Vera Myelofibrosis|Post- Essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Dronabinol to Treat Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Dronabinol|DRUG: Placebo (for Dronabinol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: mesna|DRUG: methotrexate|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Supplementation of Critical Nutrients in a Plant-based Diet
Status: COMPLETED
Conditions: Deficiency, Vitamin|Vegan's Anemia (Vitamin B12 Deficiency)|Deficiencies Micronutrient
Interventions: OTHER: Questionnaire on the topic "Supplementation of critical nutrients in a plant-based diet"
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Immunogenicity of a Split-Virion Pandemic Influenza A (H5N1) Vaccine in Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: split-virion pandemic influenza vaccine (H5N1 strain NIBRG-14)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Sertraline and Cognitive Behavioral Therapy in Treating Pediatric Obsessive-Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Regular Titration|DRUG: Placebo|DRUG: Slow Titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Dance Therapy in Women With Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Chronic Pain|Chronic Low-back Pain
Interventions: OTHER: Dance Therapy Group|OTHER: Exercise Group|OTHER: Pyhsiotherapy Modalities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hepa Wash Treatment of Patients With Acute-on-Chronic Liver Failure in Intensive Care Units
Status: TERMINATED
Conditions: Acute on Chronic Hepatic Failure
Interventions: DEVICE: ADVOS (Hepa Wash)|PROCEDURE: Standard Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HBPL Study of the Impact of the NK1 Antagonist Aprepitant
Status: COMPLETED
Conditions: Cocaine Dependence|Alcohol Dependence
Interventions: DRUG: Placebo session 1, Aprepitant session 2|DRUG: Placebo session 1, Placebo session 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition Education for Low-Income Healthy Participants Who Eat an Unhealthy Diet
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BEHAVIORAL: behavioral dietary intervention|OTHER: educational intervention|OTHER: preventative dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Choline and Iron Deficiency
Status: NOT_YET_RECRUITING
Conditions: Pediatric Iron Deficiency|Anemia
Interventions: DRUG: choline bitartrate|OTHER: placebo drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Examining the Effectiveness of a Tablet Video Game on Mood and Cognition
Status: COMPLETED
Conditions: Mood Disturbance|Depressive Symptoms
Interventions: BEHAVIORAL: LOH game- high dose|BEHAVIORAL: LOH game- low dose|BEHAVIORAL: LOH sham game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 13-year Follow-up of Women With Chronic Low Back Pain in Primary Care - a Prospective Longitudinal Cohort Study
Status: UNKNOWN
Conditions: Low Back Pain|Chronic Widespread Pain|Predictors|Pain|Physical Activity|Work Ability
Interventions: OTHER: Change in function, activity, participation and other health related factors in CLBP and to identify predictors for pain, activity and work ability after 13 years.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Observation of 1565nm Non-ablative Fractional Laser in the Treatment of Androgenic Alopecia
Status: RECRUITING
Conditions: Androgenic Alopecia
Interventions: DEVICE: 1565nm Non-ablative Fractional Laser|DRUG: 5% minoxidil external use|DEVICE: 1565nm Non-ablative Fractional Laser combined with 5% minoxidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT