pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Neuromodulatary Efficacy of Transcranial Direct Current Stimulation in Severe Refractory Primary Dysmenorrhea
Status: COMPLETED
Conditions: Primary Dysmenorrhea
Interventions: DEVICE: Active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer
Status: RECRUITING
Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Oropharyngeal HPV-Positive Squamous Cell Carcinoma
Interventions: RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carnoy's Solution Versus Formalin in Rectal and Gastric Cancer Specimens Following: a Randomized Trial
Status: COMPLETED
Conditions: Rectal Cancer|Gastric Adenocarcinoma
Interventions: OTHER: Carnoy's solution|OTHER: 10% neutral buffered formaldehyde
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Open-label Extension Study of Brazikumab in Crohn's Disease
Status: TERMINATED
Conditions: Crohn's Disease|IBD
Interventions: DRUG: Brazikumab Induction Dose|DRUG: Brazikumab Maintenance Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Ketamine and Propofol Anesthesia for Electroconvulsive Therapy
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DRUG: Propofol|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Novel Positron Emission Tomography (PET Radiotracer for TARP Gamma-8
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: PROCEDURE: Brain Imaging (PET)|PROCEDURE: Aterial Line|PROCEDURE: Blood Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Multiple Rising Doses of TAK-137 in Adults With Attention-Deficit/Hyperactivity Disorder.
Status: TERMINATED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DRUG: TAK-137|DRUG: TAK-137 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cognitive Behavioural Therapy and Bright Light Therapy for Insomnia in Adolescents With Evening Chronotype
Status: RECRUITING
Conditions: Insomnia|Delayed Sleep Phase
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy for Insomnia (CBT-I) + Bright Light Therapy|BEHAVIORAL: Cognitive Behavioural Therapy for Insomnia (CBT-I) + Placebo Light Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Study in Patients With Chronic Obstructive Pulmonary Disease (COPD) Associated Pulmonary Hypertension.
Status: COMPLETED
Conditions: Hypertension, Pulmonary|Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Riociguat (Adempas, BAY63-2521) 1.0 mg|DRUG: Riociguat (Adempas, BAY63-2521) 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Allergen BioCube (ABC) Study Evaluating the Efficacy of Fluticasone Propionate Nasal Spray Compared to Placebo
Status: COMPLETED
Conditions: Allergic Rhinitis|Allergic Conjunctivitis
Interventions: DRUG: Fluticasone Propionate Nasal Spray|DRUG: Saline Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sorafenib Combined With Transarterial Chemoembolization in Treating HBV-infected Patients With Intermediate Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: PHENYTOIN/SORAFENIB [VA Drug Interaction]|Liver Neoplasms|Carcinoma, Hepatocellular|Digestive System Neoplasms|Neoplasms by Site|Liver Diseases|Adenocarcinoma|Carcinoma|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|DOXORUBICIN/TRASTUZUMAB [VA Drug Interaction]|HBV
Interventions: PROCEDURE: Transarterial Chemoembolization (TACE)|OTHER: Sorafenib in combination with TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injured Spinal Cord Pressure Evaluation
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: PROCEDURE: Insertion of intra spinal sub dural pressure monitor|PROCEDURE: Insertion of sub dural microdialysis probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SR-Registration Study 1, ROW: Efficacy and Safety of Seroquel® in the Treatment of Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenic Disorder
Interventions: DRUG: Seroquel Sustained Release (SR)|DRUG: Seroquel Immediate Release (IR)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans
Status: COMPLETED
Conditions: Insulin Resistance, Diabetes
Interventions: OTHER: Placebo capsules|OTHER: 2g capsules|OTHER: 4g capsules|OTHER: Water Control|OTHER: 2g tablets|OTHER: 4g tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Blood Flow Restriction Training on Hamstring Elasticity After Injury
Status: RECRUITING
Conditions: Hamstring Injury
Interventions: DEVICE: Blood Flow Restriction Training|DEVICE: Sham Blood Flow Restriction Training|OTHER: Classic rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Benefit of Ultrasound Guidance in Arteriovenous Fistula (AVF) Cannulation in Pediatric Hemodialysis
Status: RECRUITING
Conditions: Arteriovenous Fistula Cannulation
Interventions: OTHER: Ultrasound-guided AVF cannulation method|OTHER: Conventional AVF cannulation method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Comparing of With and Without Sequential Therapy of S-1
Status: RECRUITING
Conditions: Locally Advanced Gastric Adenocarcinoma|Chemotherapy Effect
Interventions: DRUG: Docetaxel|DRUG: Tegafur-Gimeracil-Oteracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PGS on Blastocysts From Vitrified and Fresh Oocytes
Status: COMPLETED
Conditions: Increase the Number of Blastocyst to Biopsy for Preimplantation Genetic Testing
Interventions: OTHER: chromosomal status of blastocysts from fresh and vitrified/warmed oocytes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Fasting-Mimicking Diet on Central and Peripheral Components of Fatigue, Muscular Resistance
Status: COMPLETED
Conditions: Fatigue; Muscle, Heart|Fasting|Diet, Healthy|Fatigue, Mental
Interventions: DIETARY_SUPPLEMENT: Fasting-Mimicking Diet (ProLon®)|DIETARY_SUPPLEMENT: Placebo bars
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Epodure Therapy of Anemia in End Stage Renal Disease on Dialysis With Epodure Skin Implant
Status: TERMINATED
Conditions: Anemia|End Stage Renal Disease
Interventions: PROCEDURE: implantation of autologous skin graft after ex-vivo treatment|BIOLOGICAL: Subcutan implantation of autologus skin graft after ex-vivo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Consciousness by EEG and Auditory Evoked Potentials
Status: COMPLETED
Conditions: Anesthesia|Electroencephalography/ Drug Effect
Interventions: DRUG: Propofol / Remifentanil|DRUG: Sevoflurane / Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dysbiosis and Immune Reconstitution After Allo-HSCT
Status: UNKNOWN
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: BIOLOGICAL: blood samples|BIOLOGICAL: fecal samples|BEHAVIORAL: Anxiety test|BEHAVIORAL: Stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acupuncture for Vasectomy Pre-procedural Anxiety and Pain Control in the Primary Care Setting
Status: RECRUITING
Conditions: Acupuncture|Pain, Postoperative|Vasectomy
Interventions: PROCEDURE: Acupuncture|OTHER: Standardized pre-procedure medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Histological Study Evaluating Silk Voice and Crosslinked Hyaluronic Acid
Status: COMPLETED
Conditions: Vocal Fold Palsy|Vocal Cord Paralysis|Vocal Cord Atrophy
Interventions: DEVICE: Silk Voice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord|Metastatic Epidural|Spine Stereotactic
Interventions: RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of SAR341402 to NovoLog in Adult Patients With Type 1 Diabetes Mellitus Also Using Insulin Glargine
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin Aspart SAR341402|DRUG: Insulin Aspart|DRUG: Insulin glargine U100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of DDO-3055 in Healthy Volunteers and Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: DDO-3055|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modified LPB and SPB vs Classical LPB and SPB
Status: RECRUITING
Conditions: Anesthesia, Local
Interventions: PROCEDURE: Combined anterior lumbar plexus and lateral sacral plexus block in a semi-supine position|PROCEDURE: Combined anterior lumbar plexus and lateral sacral plexus block in a classical position.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort
Status: RECRUITING
Conditions: Breast Neoplasms|Radiation Pneumonia|Radiation Pneumonitis|Radiation Induced Fibrosis
Interventions: RADIATION: Radiation therapy protocol for Breast cancer|DIAGNOSTIC_TEST: Spirography and assessment of pulmonary diffusion capacity|DIAGNOSTIC_TEST: Cardiopulmonary stress test|DIAGNOSTIC_TEST: Computed tomography of the chest organs|DIAGNOSTIC_TEST: SF-36 Quality of Life Questionnaire|DIAGNOSTIC_TEST: Demographic and anthropometric measures|OTHER: Indicators characterizing the severity of the underlying disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Absorption of Mango in Healthy Individuals
Status: UNKNOWN
Conditions: Absorption; Chemicals
Interventions: DIETARY_SUPPLEMENT: Mango polyphenolics|DIETARY_SUPPLEMENT: Sugary beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Trial of Acetazolamide for Uveitis-Associated Cystoid Macular Edema
Status: COMPLETED
Conditions: Macular Edema, Cystoid
Interventions: DRUG: Acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Observation on the Immune Persistence of People Aged 10-60 Years Old Immunized With Five Doses of Rabies Vaccine
Status: COMPLETED
Conditions: Rabies|Antibody
Interventions: BIOLOGICAL: 5 doses program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial in Painful Diabetic Peripheral Neuropathy With GRT3983Y
Status: TERMINATED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: GRT3938Y|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Fenestration Decompression Combined With Secondary Curettage for Ameloblastoma of the Jaw: Retrospective Radiographic Analysis
Status: COMPLETED
Conditions: Cystic Cavity Area Reduction Efficiency|the Recurrence of the Tumor
Interventions: PROCEDURE: fenestration decompression combined with secondary curettage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dry Needling in Post-operative Shoulder Pain
Status: COMPLETED
Conditions: Proximal Humeral Fracture Fixated With PHILOS© Plate|Rotator Cuff Tear Surgical Repair
Interventions: OTHER: Physical therapy plus dry needling|OTHER: Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-Hormone Therapy (With Anastrazole and Fulvestrant) Before Surgery to Treat Postmenopausal Women With Breast Cancer.
Status: COMPLETED
Conditions: Invasive Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Anastrazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Microbial Sealant to Reduce Surgical Site Infections.
Status: COMPLETED
Conditions: Surgical Site Infection|SCIP
Interventions: PROCEDURE: Open Colorectal Surgery|PROCEDURE: Laparoscopic Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: S. Aureus Screening and Decolonization
Status: COMPLETED
Conditions: Wound Infection Due to Staphylococcus Aureus|MRSA Infection of Postoperative Wound
Interventions: DRUG: antiseptic bundle|DRUG: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Novel SUBCUTaneous Preparation of Furosemide to Facilitate Early Supported Discharge of Patients With Heart Failure
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: SQIN-Furosemide|DEVICE: SQIN-Infusor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbon Monoxide and Oxidative Stress in Waterpipe Smokers
Status: COMPLETED
Conditions: Waterpipe Smoking|Oxidative Stress
Interventions: PROCEDURE: Breath carbon monoxide|PROCEDURE: Pulmonary function tests.|PROCEDURE: Oxidative stress and antioxidant status.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study To Assess Adverse Events and Drug to Drug Interaction of Oral Tablet Atogepant and Ubrogepant in Adult Participants With a History of Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Atogepant|DRUG: Ubrogepant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxymetazoline Drops for Acquired Blepharoptosis From Synkinesis
Status: ENROLLING_BY_INVITATION
Conditions: Blepharoptosis|Synkinesis|Hyperkinesis|Facial Paralysis
Interventions: DRUG: Oxymetazoline 0.1% (Pf) Oph Soln Ud|OTHER: Preservative free lubricating drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First Line Pazopanib in Poor Risk Patients With Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Locally Advanced and/or Metastatic Renal Cell Carcinoma|Carcinoma, Renal Cell|Clear-cell Metastatic Renal Cell Carcinoma
Interventions: DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAMPUS - Feasibility Sub-Study
Status: COMPLETED
Conditions: Suicide
Interventions: BEHAVIORAL: TAU - Phase 1|BEHAVIORAL: CAMS - Phase 1|BEHAVIORAL: DBT - Phase 1 and 2|BEHAVIORAL: CAMS - Phase 2|BEHAVIORAL: DBT - Phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Study to Evaluate Peginterferon in Reducing the Incidence of HCC in CHB Patients
Status: RECRUITING
Conditions: Chronic Hepatitis B|Intermediate to High Risk of HCC
Interventions: DRUG: Peginterferon alfa-2b Injection, Nucleos (t) ide Analogue|DRUG: Nucleos(t)ide analogue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Assess the Pharmacokinetics of Metformin When Administered Alone and in Combination With Vandetanib
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin 1000 mg|DRUG: Vandetanib 800 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Test Whether Survodutide (BI 456906) Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose Weight
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: survodutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetic Macular Edema - Obstructive Sleep Apnea Relationship Study
Status: UNKNOWN
Conditions: Diabetic Macular Edema|Sleep Apnea|Non Proliferative Diabetic Retinopathy
Interventions: DRUG: Aflibercept 40 MG/ML [Eylea]|DIAGNOSTIC_TEST: OSA diagnostic test - overnight sleep study|DEVICE: CPAP therapy for OSA positive patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laparoscopic and Endoscopic Collaborative Surgery as Rescue-treatment for Advanced Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: PROCEDURE: Laparoscopic and Endoscopic Collaborative Surgery (LECS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Comparing Pegylated rhG-CSF（HHPG-19K） and rhG-CSF in Breast Cancer Patients Receiving Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer|Neutropenia|Febrile Neutropenia
Interventions: DRUG: Pegylated rhG-CSF 100μg/kg|DRUG: Pegylated rhG-CSF:150 μg/kg|DRUG: rhG-CSF 5 μg/kg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Joint Replacement or Interpositional Arthroplasty for CMC1 Arthritis, a Prospective Trial
Status: COMPLETED
Conditions: Osteoarthrosis of the Carpometacarpal Joint of the Thumb
Interventions: PROCEDURE: Interpositional arthroplasty (Burton-Pellegrini procedure)|PROCEDURE: Total joint replacement|DEVICE: Elektra prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: This Study is a Prospective, Multi-center, Real World, Observational Study, Which Aims at Evaluating Intermediate and Long-term Efficacy of Endovascular Treatment for TASC C&D Aortoiliac Occlusive Disease.
Status: RECRUITING
Conditions: Peripheral Arterial Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Neutral Peritoneal Dialysis (PD) Solution With Minimal Glucose-Degradation-Product (GDP) on Fluid Status and Body Composition
Status: COMPLETED
Conditions: Renal Failure|ESRD|Cardiovascular Disease
Interventions: OTHER: double-chamber bag Stay-Safe Balance system|OTHER: glucose-based dialysis solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ertugliflozin 5 mg|DRUG: Ertugliflozin 15 mg|DRUG: Placebo for ertugliflozin 5 mg|DRUG: Metformin|DRUG: Sitagliptin|DRUG: Glimepiride|BIOLOGICAL: Insulin|DRUG: Placebo for ertugliflozin 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study With FLOT in Patients With Locally Advanced, Limited Metastatic or Extensive Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction
Status: COMPLETED
Conditions: Gastric Cancer|Adenocarcinoma of the Esophagogastric Junction
Interventions: DRUG: Docetaxel|DRUG: 5-Fluorouracil|DRUG: Oxaliplatin|DRUG: folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Network Disruptions Related to Traumatic Coma
Status: COMPLETED
Conditions: Traumatic Coma
Interventions: RADIATION: PET examination with radiopharmaceutical drug [18F] DPA-714|DIAGNOSTIC_TEST: MRI examination|BIOLOGICAL: Blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other Cancers
Status: RECRUITING
Conditions: HPV-Related Squamous Cell Carcinoma
Interventions: DRUG: HB-201 intravenous administration.|DRUG: HB-202 intravenous administration alternating with HB-201 intravenous administration.|DRUG: HB-201 intravenous administration + standard of care regimen including pembrolizumab.|DRUG: HB-202 / HB-201 alternating intravenous administration + pembrolizumab.|DRUG: HB-202 / HB-201 alternating intravenous administration + standard of care regimen including pembrolizumab.|DRUG: HB-201 or HB-201/HB-202 alternating treatment using CD8 PET Tracer (Zr-Df-IAB22M2C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Organ Transplantation Rehabilitation: Effect of Bedside Exercise Device and Activity Reinforcement
Status: UNKNOWN
Conditions: Heart Transplantation|Liver Transplantation
Interventions: BEHAVIORAL: direct feedback about exercise|BEHAVIORAL: PLacebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of I-131-CLR1404 in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: I-131-CLR1404|DRUG: dexamethasone|DRUG: I-131-CLR1404
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Plus Oxaliplatin in Advanced Stage IIIB/IV Non Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TruSkin®: Study for the Treatment of Chronic Diabetic Foot Ulcers
Status: TERMINATED
Conditions: Diabetic Foot Ulcers
Interventions: OTHER: TruSkin®|OTHER: Wound Cover
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of HLX208 in Adult Langerhans Cell Histiocytosis (LCH) and Erdheim-Chester Disease (ECD) With BRAF V600E Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Langerhans Cell Histiocytosis|Erdheim-Chester Disease|LCH|ECD
Interventions: DRUG: HLX208
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Luspatercept (ACE-536) for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in Japanese Subjects Who Are Not Requiring Red Blood Cell Transfusion
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Luspatercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Single-Blinded Randomized Trial Comparing Colonoscopic Preparation at Different Time
Status: COMPLETED
Conditions: Colonoscopy|Colon Neoplasm
Interventions: BEHAVIORAL: Different timing of taking polyethylene glycol(PEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Pilocarpine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Trial of Anti-GD2 T-cells (1RG-CART)
Status: COMPLETED
Conditions: Relapsed or Refractory Neuroblastoma
Interventions: OTHER: Leukapheresis|DRUG: Cyclophosphamide|DRUG: Fludarabine|GENETIC: 1RG-CART
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy of 5-Fluorouracil and CALcipotriol Versus 5-Fluorouracil in the Treatment of Actinic Keratosis
Status: NOT_YET_RECRUITING
Conditions: Actinic Keratoses
Interventions: DRUG: 5FU-Calcipotriol|DRUG: 5-FU 50 MG/ML Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BI 1356 BS as Tablet in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 1356 BS, low dose|DRUG: BI 1356 BS, medium dose|DRUG: BI 1356 BS, high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Carbonated Water Enriched With Amino Acids and Chromium Picolinate (Good Idea®) on Glucose Homeostasis.
Status: COMPLETED
Conditions: Postprandial Hyperglycemia|Metabolic Syndrome|Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Carbonated water with amino acids and chromium|DIETARY_SUPPLEMENT: Placebo Carbonated Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vismodegib and Gemcitabine Hydrochloride in Treating Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Recurrent Pancreatic Carcinoma|Stage IV Pancreatic Cancer
Interventions: DRUG: Gemcitabine Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects and Prognostic Factors of Intensive Pulse Light Treatment for Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: DEVICE: Intense Pulsed Light (IPL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Occupational Therapy Pre-operative Education in the Orthopedic Hand Setting
Status: UNKNOWN
Conditions: Flexor Tendon Rupture|Thumb Osteoarthritis|Distal Radius Fracture
Interventions: OTHER: Occupational Therapy Pre-operative Consult|OTHER: Typical Pre-Operative Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tislelizumab for Lung Adenocarcinoma With Asymptomatic Brain Metastatic
Status: RECRUITING
Conditions: Lung Adenocarcinoma
Interventions: DRUG: Tislelizumab,Platinum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: Bleomycin sulfate|DRUG: Stanford V regimen|DRUG: Doxorubicin hydrochloride|DRUG: Etoposide|DRUG: Mechlorethamine hydrochloride|DRUG: Prednisone|DRUG: Vinblastine|DRUG: Vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging Lung Function Using Oxygen Enhanced MRI
Status: COMPLETED
Conditions: COPD|Asthma|Cystic Fibrosis|Emphysema|Small Airways Disease
Interventions: DRUG: Medical Grade Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children
Status: COMPLETED
Conditions: Sinusitis
Interventions: DRUG: placebo|DRUG: azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Two Techniques Used in Treatment of Long Anterior Urethral Stricture
Status: NOT_YET_RECRUITING
Conditions: Urethral Stricture, Male
Interventions: PROCEDURE: Buccal mucosa substitution urethroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RoBotic TCD Ultrasound BubbLe Study Compared to Transthoracic Echocardiography for Detection of Right to Left Shunt
Status: COMPLETED
Conditions: Embolic Stroke of Undetermined Source|Transient Ischemic Attack|Right-To-Left Atrial Shunt|Patent Foramen Ovale
Interventions: DIAGNOSTIC_TEST: NeuralBot Investigational System|DIAGNOSTIC_TEST: Transthoracic Echocardiography (TTE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CO2 Gap Changes Versus Inferior Vena Cava Collapsibility in Relation to Cardiac Index as a Prognostic Value in Septic Shock
Status: RECRUITING
Conditions: Septic Shock
Interventions: DIAGNOSTIC_TEST: CO2 GAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phenylephrine in Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diltiazem Hydrochloride Cream for Anal Fissure
Status: COMPLETED
Conditions: Chronic Anal Fissure
Interventions: DRUG: Diltiazem hydrochloride 4% cream|DRUG: Diltiazem hydrochloride 2% cream|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Long-Term Safety of Desvenlafaxine Succinate Sustained Release With Japanese Adult Subjects in Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: desvenlafaxine succinate sustained release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Eccentric Pedaling at Different Rates on Neuromuscular Function
Status: RECRUITING
Conditions: Volunteers Who Can do Moderate Physical Activity
Interventions: OTHER: Neuromuscular evaluation|OTHER: Assessment of aerobic capacity, muscle architecture and habituation to the eccentric pedaling task|OTHER: Pedaling at 15 rpm|OTHER: No pedaling, usual activity|OTHER: Pedaling at 60rpm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ex Vivo Expansion of Mafosfamide Purged CD34+ Cells in Patients With Acute Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: busulfan|DRUG: cyclophosphamide|PROCEDURE: in vitro-treated bone marrow transplantation|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Precision Therapy in Refractory Tumor
Status: UNKNOWN
Conditions: Rare Tumor|Refractory Tumor
Interventions: DRUG: Gefitinib|DRUG: Erlotinib|DRUG: Afatinib|DRUG: Trastuzumab|DRUG: Oxazolidine|DRUG: Olaparib|DRUG: Everolimus|DRUG: Cabozantinib|DRUG: Vemurafenib|DRUG: Dabrafenib|DRUG: Palbociclib|DRUG: PD-1/L1 inhibitor plus anti-angiogenic agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Holly Mangrove Shower Gel in Atopic Dermatitis Patients
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: OTHER: Placebo shower gel|OTHER: Holly Mangrove Shower Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INM-755 (Cannabinol) Cream for Treatment of Epidermolysis Bullosa
Status: COMPLETED
Conditions: Epidermolysis Bullosa Simplex|Epidermolysis Bullosa, Junctional|Epidermolysis Bullosa Dystrophica|Kindler Syndrome
Interventions: DRUG: INM-755 (cannabinol) cream|DRUG: Vehicle Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peer Activate: Trial of Peer-Delivered Behavioral Activation for Methadone Adherence
Status: RECRUITING
Conditions: Substance-Related Disorders|Opioid Medication Assisted Treatment|Opioid Use Disorder|Opioid Use|Opioid Addiction|Treatment Adherence|Retention in Care
Interventions: BEHAVIORAL: Peer-Delivered Behavioral Activation ("Peer Activate")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioactivity of Olive Oils Enriched With Their Own Phenolic Compounds (VOHF1)
Status: UNKNOWN
Conditions: Polyphenol Absorption in Healthy People
Interventions: OTHER: olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PD-L1 Targeting Nanobody Probe for PET Imaging of Solid Tumor
Status: RECRUITING
Conditions: Lung Cancer|Melanoma|PD-L1|PET/CT
Interventions: DIAGNOSTIC_TEST: 68Ga-THP-APN09
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mobile Cardiac Outpatient Telemetry for Unexplained Syncope
Status: NOT_YET_RECRUITING
Conditions: Syncope|Arrhythmia|Near Syncope|Arrhythmias, Cardiac
Interventions: DEVICE: Mobile Cardiac Outpatient Telemetry Device (MCOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Out-Patient Study in Patients With Type 2 Diabetes Mellitus Who Are Taking no Diabetes Medication or Metformin Only
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Albiglutide (GSK716155) or exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder
Status: COMPLETED
Conditions: Acute Tendonitis|Bursitis
Interventions: DRUG: MRX-7EAT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Acupuncture for Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Disposable stainless steel acupuncture (0.2mmx4mm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Placebo-controlled Study of Oral Dimebon in Subjects With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Dimebon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation Therapy and Ipilimumab in Treating Patients With Stages IB2-IIB or IIIB-IVA Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Stage IB2 Cervical Cancer AJCC v6 and v7|Stage II Cervical Cancer AJCC v7|Stage IIA Cervical Cancer AJCC v7|Stage IIB Cervical Cancer AJCC v6 and v7|Stage IIIB Cervical Cancer AJCC v6 and v7|Stage IVA Cervical Cancer AJCC v6 and v7
Interventions: DRUG: Cisplatin|RADIATION: External Beam Radiation Therapy|RADIATION: Internal Radiation Therapy|BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Contraceptive Pill (OCP) Pharmacogenomics
Status: NOT_YET_RECRUITING
Conditions: Contraception|Pharmacogenomic Drug Interaction
Interventions: DRUG: Desogestrel / Ethinyl Estradiol Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthesia on Optic Nerve Sheath Diameter
Status: COMPLETED
Conditions: Optic Nerve Sheath Diameter
Interventions: PROCEDURE: The Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath Diamater
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Laughter Yoga on the Secondary Traumatic Stress Level and Psychological Well-Being of Midwives
Status: NOT_YET_RECRUITING
Conditions: Laughter Yoga
Interventions: OTHER: group-based laughter yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Transversalis Fascia Plane Block and Rectus Sheath Block in Renal Transplantation Donors
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Transversalis fascia plane block and rectus sheath block|DEVICE: Intravenous fentanyl patient control device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Korean Post-marketing Surveillance Study on Erbitux® in Patients With Metastatic Colorectal Cancer Refractory to Irinotecan-containing Treatment
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Erbitux (Cetuximab)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tidal Volume Challenge and Lung Recruitment Maneuver (TIDALREC): the Reliability of Pulse Pression Variation or Stroke Volume Variation on Fluid Responsiveness.
Status: COMPLETED
Conditions: Fluid Challenge|Hemodynamic Monitoring
Interventions: PROCEDURE: Starting LRM (Lung Recruitment Maneuver)|PROCEDURE: Starting VtC (Tidal Volume Challenge)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Treatment of Chronic Diabetic Foot Ulcers by Minimally Invasive Surgery
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer|Diabetic Foot|Diabetic Foot Infection|Diabetic Foot Ulcer Neuropathic|Deformities Foot
Interventions: OTHER: Distal Metatarsal Minimally invasive Osteotomy (DMMO)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating The Safety, Tolerability, And Efficacy Of Switching From Quetiapine To Ziprasidone
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hepatic Vein Pressure Gradient(HVPG)-Guided Therapy in Cirrhotic Patients With Esophagogastric Varices
Status: UNKNOWN
Conditions: Gastroesophageal Varices|Cirrhosis
Interventions: PROCEDURE: HVPG-guided therapy|OTHER: routine therapy|DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Docetaxel Followed by Doxorubicin Plus Cyclophosphamide for Node Positive or High-Risk Primary Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyberknife Radiosurgery for Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DEVICE: Stereotactic Radiosurgery (Cyberknife)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lung Cancer Informational Study (LCIS)
Status: COMPLETED
Conditions: Cancer|Enhanced Care|Decision-Making|Advance Lung Cancer|Stage III Lung Cancer|Stage IV Lung Cancer
Interventions: BEHAVIORAL: Enhance Care|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Crosslinked Hyaluronic Acid With Liposomes and Crocin in Dry Eye
Status: COMPLETED
Conditions: Dry Eye|Meibomian Gland Dysfunction|Dry Eye Syndromes
Interventions: DRUG: Hylauronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vinflunine and Capecitabine in Treating Patients With Previously Treated Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: capecitabine|DRUG: vinflunine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Single and Multiple Ascending Doses of ZE46-0134 in Healthy Volunteers
Status: RECRUITING
Conditions: AML
Interventions: DRUG: ZE46-0134 or placebo|DRUG: Rabeprazole, 20mg oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of PF-06741086 In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: PF-06741086|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0
Status: RECRUITING
Conditions: Rectal Cancer, Adenocarcinoma
Interventions: PROCEDURE: Tailored surgery|PROCEDURE: Total mesorectal excision (TME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Recovery of Functional Capillary Surface Area in Patients Undergoing a Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Status: RECRUITING
Conditions: Hypertension, Pulmonary|Pulmonary Thromboembolisms
Interventions: OTHER: Measurement of pulmonary functional capillary surface area
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: TMC125-TiDP2-C188: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Effect of Multiple-dose TMC125 on Buprenorphine and Norbuprenorphine Administered in HIV-negative Patients on Stable Buprenorphine/Naloxone Maintenance Therapy.
Status: COMPLETED
Conditions: HIV|Pharmacokinetics
Interventions: DRUG: TMC125
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT