pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pioglitazone in Patients With Mood Disorders
Status: COMPLETED
Conditions: Major Depressive Disorder|Insulin Resistance
Interventions: DRUG: Pioglitazone|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Kinesio Tape and Dry Needling for the Management of Rotator Cuff Tendinopathy: A Randomized Control Trial
Status: COMPLETED
Conditions: Rotator Cuff Tendinopathy
Interventions: OTHER: kinesio tape|OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: BI 655066 Versus Placebo & Active Comparator (Ustekinumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: risankizumab|DRUG: ustekinumab|DRUG: placebo for risankizumab|DRUG: placebo for ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PALACE 2: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Apremilast 20mg|DRUG: Apremilast 30mg|DRUG: Placebo + 20 mg Apremilast|DRUG: Placebo + 30 mg Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Treatment Modalities of Peri-implantitis - Blue Laser (445 nm) and Conventional Flap Surgery
Status: WITHDRAWN
Conditions: Peri-Implantitis
Interventions: DEVICE: Laser treatment|PROCEDURE: Mucosal flap surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention for Anxiety After Falls
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder (PTSD)|Specific Phobia|Anxiety
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Relaxation Training|BEHAVIORAL: Cognitive Restructuring|BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke.
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Ginkgolides Meglumine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of a New Immunotherapy Using Intramuscular Administration of Autologous Total IgG
Status: COMPLETED
Conditions: Immunotherapy
Interventions: BIOLOGICAL: Part A) Healthy subjects|BIOLOGICAL: Part B) Advanced solid tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Urtica Dioica on Glycemic Control in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Urtica Dioica (Tea bag)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Starches of Boba Pearls and Sugar Substitutes Used in Milk Tea on Glycaemia, Insulinaemia and Appetite Control (Pearl Study)
Status: COMPLETED
Conditions: Diabete Type 2|Obese
Interventions: OTHER: Starch 1|OTHER: Starch 2|OTHER: Starch 3|OTHER: Starch 4|OTHER: Sugar 1|OTHER: Sugar 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of a New Hysteroscopic Grasper for Endometrial Biopsy in Post-menopausal Patients
Status: COMPLETED
Conditions: Post-Menopausal Bleeding|Post-Menopausal Endometrial Thickness
Interventions: DIAGNOSTIC_TEST: Endometrial biopsy with the new hysteroscopic grasper with knurled terminal end and cutting jaws|DIAGNOSTIC_TEST: Endometrial biopsy with the hysteroscopic spoon grasper|DIAGNOSTIC_TEST: Endometrial biopsy with the hysteroscopic alligator grasper
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure
Status: RECRUITING
Conditions: Atrial Fibrillation|Stroke
Interventions: DEVICE: Imaging guidance with TEE and ICE for Left atrial appendage closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Parmigiano Reggiano on Muscle and Inflammatory Response to Eccentric Resistance Training in Older Adults
Status: UNKNOWN
Conditions: Atrophy, Muscular|Aging|Inflammation|Cholesterol Deposition
Interventions: DIETARY_SUPPLEMENT: Parmigiano Reggiano|DIETARY_SUPPLEMENT: Whey Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of an Investigational Drug in Adult Patients With Non Small-Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Neoplasms
Interventions: DRUG: Investigational drug
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ambulatory ECG Telemetry for the Early Detection of Atrial Fibrillation During Hospital Assessment of Cerebral Infarction
Status: TERMINATED
Conditions: Cerebral Infarction
Interventions: DEVICE: ECG telemetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Recombinant Bovine Lactoferrin (rbLf) in Iron Regulation
Status: RECRUITING
Conditions: Exercise Performance
Interventions: DIETARY_SUPPLEMENT: Recombinant Bovine Lactoferrin|DIETARY_SUPPLEMENT: Bovine Milk-Derived Lactoferrin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Phase II Study With the Trifunctional Antibody Ertumaxomab to Treat Metastatic Breast Cancer After Progression on Trastuzumab Therapy
Status: TERMINATED
Conditions: Metastatic Breast Cancer|Advanced Breast Cancer
Interventions: DRUG: ertumaxomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NerveTrend vs. i-IONM in Prevention of Recurrent Laryngeal Nerve Events During Bilateral Thyroid Surgery.
Status: UNKNOWN
Conditions: Thyroid Diseases|Surgery|Recurrent Laryngeal Nerve Injuries
Interventions: DEVICE: Neuromonitoring of the recurrent laryngeal nerves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MyPal ePRO-based Early Palliative Care System in Adult Patients With Hematologic Malignancies
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leukemia|Myelodysplastic Syndromes
Interventions: OTHER: Administration of the MyPal ePRO system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial to Find Out if REGN5678 is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer (mCRPC)|Clear Cell Renal Cell Carcinoma (ccRCC)
Interventions: DRUG: REGN5678|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Freedom Bed Compared to Manual Turning in Prevention of Pressure Injuries in Persons With Limited Mobility Due to Traumatic Brain Injury and/or Spinal Cord Injury.
Status: UNKNOWN
Conditions: Pressure Ulcer
Interventions: DEVICE: Freedom Bed|OTHER: Standard hospital bed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plerixafor in Diabetic Wound Healing
Status: TERMINATED
Conditions: Diabetes|Wounds|Critical Limb Ischemia
Interventions: DRUG: Plerixafor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Pharmacological Basis for the Increase in Visual Time Constants Induced by Single Oral Doses of Sildenafil
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: DRUG: sildenafil|DRUG: tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Back Pain Consortium Research Program Study
Status: RECRUITING
Conditions: Chronic Low-back Pain
Interventions: BEHAVIORAL: PainGuide|BEHAVIORAL: MBSR|BEHAVIORAL: PT and exercise|DEVICE: Self -administered acupressure|DRUG: Duloxetine|DEVICE: Pro-Diary monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Cannula HFNC In Covid-19 Patients
Status: UNKNOWN
Conditions: SARS-CoV Infection|SARS (Severe Acute Respiratory Syndrome)
Interventions: DEVICE: High flow nasal cannula HFNC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Treatment for Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Follow-up probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Non Severe Aplastic Anemia Treated With Cyclosporine, Androgen and Levamisole
Status: UNKNOWN
Conditions: Aplastic Anemia
Interventions: DRUG: levamisole hydrochloride|DRUG: Androgens|DRUG: Cyclosporins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition
Status: UNKNOWN
Conditions: Narcolepsy
Interventions: DRUG: Orexine A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Three Strategies for Implementing Motivational Interviewing on Medical Inpatient Units
Status: COMPLETED
Conditions: See One|Do One|Order One
Interventions: BEHAVIORAL: See One|BEHAVIORAL: Do One|BEHAVIORAL: Order One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Ibandronate [Bonviva/Boniva] and Alendronate in Female Patients With Post-Menopausal Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: alendronate|DRUG: ibandronate [Bonviva/Boniva]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subscapularis Strength After Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Shoulder Osteoarthritis
Interventions: PROCEDURE: Subscapularis Rehabilitation|PROCEDURE: Standard Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Therapy With a Loco-regional Treatment in Patients With Locally Advanced Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Pancreatic Cancer|Irreversible Electroporation
Interventions: DEVICE: Irreversible electroporation (NanoKnife® )
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate for Ptsd and Stroke Veterans
Status: RECRUITING
Conditions: PTSD|Stroke
Interventions: DRUG: Methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of MDRT vs CEE on Pulmonary Functions, Chest Expansion and Asthma Control in Asthma Patients
Status: RECRUITING
Conditions: Asthma
Interventions: OTHER: Manual Diaphragmatic Release Technique|OTHER: Chest Wall Expansion Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin for Treatment-Resistant Depression
Status: ENROLLING_BY_INVITATION
Conditions: Major Depressive Disorder|Anhedonia|Treatment Resistant Depression
Interventions: DRUG: Psilocybin 25mg|DRUG: Placebo (active placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects Two Diets Combined With Exercise in Persons With Abdominal Obesity (The SHAPE5 Study)
Status: COMPLETED
Conditions: Overweight|Obese|Sedentary|Abdominal Obesity
Interventions: BEHAVIORAL: Weight Loss Diets Plus Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of dRAST on Treatment for Bacteremia in Patients With Hematologic Diseases
Status: COMPLETED
Conditions: Hematologic Diseases|Bacteremia Sepsis
Interventions: DIAGNOSTIC_TEST: dRAST|DIAGNOSTIC_TEST: Current standard method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavioral Therapy and Tai Chi Chih for Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Tai Chi Chih|BEHAVIORAL: Health Education Seminar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Music Therapy in Controlling Symptoms in Patients With AML and Undergoing HSCT
Status: COMPLETED
Conditions: Acute Myeloblastic Leukemia|Hematopoietic Stem Cell Transplantation
Interventions: BEHAVIORAL: Passive music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Glucose-Dependent Insulinotropic Polypeptide - Effects on Markers of Bone Turnover in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: GIP|OTHER: GLP-1|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)
Status: TERMINATED
Conditions: Chronic Thromboembolic Pulmonary Hypertension|CTEPH
Interventions: DRUG: Riociguat|DRUG: Placebo|PROCEDURE: Pulmonary endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Autologous Mesenchymal Stem Cell Transplantation in Chronic Spinal Cord Injury: a Pilot Study
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: OTHER: Mesenchymal stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Amivantamab|DRUG: Tepotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AG-120 in Previously Treated Advanced Cholangiocarcinoma With IDH1 Mutations (ClarIDHy)
Status: COMPLETED
Conditions: Advanced Cholangiocarcinoma|Metastatic Cholangiocarcinoma
Interventions: DRUG: AG-120|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of KCC Peptide Application in the Colon
Status: COMPLETED
Conditions: Colon Polyps|Colorectal Cancer|Inflammatory Bowel Disease (IBD)
Interventions: BIOLOGICAL: Colon KCC Heptapeptide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Efficacy Study of Encapsulated Human Islets Allotransplantation to Treat Type 1 Diabetes
Status: WITHDRAWN
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: Encapsulated human islets in a "Monolayer Cellular Device"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study With Technolas® TENEO 317 Model 2 Excimer Laser to Treat Participants With Myopia or Myopic Astigmatism
Status: COMPLETED
Conditions: Myopia|Myopic Astigmatism
Interventions: DEVICE: Technolas® TENEO 317 Model 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Ceftolozane/tazobactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: IVOS cerebral oximeter|DEVICE: Licox cerebral oxygenation monitor|OTHER: Cerebral oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does the Reduction of Total Body Iron Storage (TBIS) Alter Mortality in a Population of Patients With Advanced PVD?
Status: COMPLETED
Conditions: Atherosclerosis|Intermittent Claudication|Peripheral Vascular Diseases
Interventions: PROCEDURE: Ferritin reduction to 25 ng/ml by phlebotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Ivacaftor in Subjects With Cystic Fibrosis (CF) Who Have the R117H-CF Transmembrane Conductance Regulator (CFTR) Mutation (KONDUCT)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ivacaftor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: US-guided FICB After Hip Fracture: the Effect of the Local Anesthetic Volume on the Quality of Preoperative Analgesia
Status: COMPLETED
Conditions: Hip Fractures
Interventions: PROCEDURE: supra inguinal fascia iliaca block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss
Status: COMPLETED
Conditions: Cognition Disorders
Interventions: DRUG: Placebo|DRUG: Solanezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery
Status: COMPLETED
Conditions: Anesthesia|Analgesia|Acute Pain|Chronic Pain|Pectoralis Nerve Block|Erector Spine Plane Block|Patient Controlled Analgesia
Interventions: PROCEDURE: Pectoralis nerve block II|PROCEDURE: Erector spine plane block|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance
Status: TERMINATED
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction|Heart Failure Acute|Cardiovascular Diseases
Interventions: DRUG: Metolazone Oral Tablet|DRUG: Chlorothiazide Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Lignocaine Injections as a Treatment Option for Acute Lumbosacral Radiculopathy
Status: UNKNOWN
Conditions: Pain, Acute
Interventions: PROCEDURE: peripheral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 5-aza-2-deoxycytidine With Pegylated Interferon-alfa 2B: A Phase I Study With Molecular Correlates
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Decitabine and Pegylated Interferon-Alfa 2B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effects of Dexmedetomidine and Lidocaine on Blood Pressure and Heart Rate Response
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Lidocain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HPV-Based Screen-and-Treat Demonstration Project in Lilongwe
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV Infection|Cervical Cancer|HIV Infections
Interventions: PROCEDURE: VIA and thermocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Stainless-Steel, Zirconia and Fiberglass Crowns for Deciduous Molars
Status: COMPLETED
Conditions: Caries of Infancy
Interventions: OTHER: stainless steel crown|OTHER: zirconia crown|OTHER: fiberglass crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Infant Formulas Fed to Infants With Common Feeding Problems
Status: COMPLETED
Conditions: Common Infant Feeding Problems
Interventions: OTHER: Marketed milk-based lactose-containing infant formula|OTHER: Marketed milk-based lactose-free infant formula|OTHER: Marketed soy-based lactose-free infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Dalteparin in Preventing DVT in Participants With Cancer
Status: COMPLETED
Conditions: Bone Sarcoma|Femur Fracture|Lymphoma|Metastatic Neoplasm|Pathologic Fracture|Plasma Cell Myeloma|Soft Tissue Sarcoma
Interventions: DRUG: Dalteparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: rabbit anti-thymocyte globulin (ATG)|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: busulfan|DRUG: fludarabine phosphate|DRUG: tacrolimus|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Busulfan (BU) Plus Fludarabine Vs Intravenous BU Plus Cyclophosphamide as Conditioning Regimens Prior Allogeneic Hematopoetic Stem Cells Transplant (HSCT) in AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: Busulphan plus Cyclophosphamide|DRUG: Busulphan plus Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pilates Standing Exercises on Walking Mobility and Postural Balance
Status: COMPLETED
Conditions: Aging|Mobility Limitation|Postural Balance
Interventions: OTHER: Standing Pilates protocol|OTHER: Standard Pilates protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Comparative Study of the Effect of Ezetimibe Versus Extended-Release Niacin on Atherosclerosis
Status: TERMINATED
Conditions: Atherosclerosis
Interventions: DRUG: extended release niacin|DRUG: ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ile-Pro-Pro (IPP) on Endothelial Function in Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: IPP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Specific Strength-Training on Tension-Type Headache in Children 9-17 Years
Status: COMPLETED
Conditions: Tension-Type Headache
Interventions: DEVICE: Specific Strength Training|BEHAVIORAL: Lifestyle Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration
Status: RECRUITING
Conditions: Low Grade Glioma (LGG) of Brain With BRAF Aberration|High Grade Glioma (HGG) of the Brain With BRAF Aberration|Low Grade Glioma of Brain With Neurofibromatosis Type 1
Interventions: DRUG: Dabrafenib|DRUG: Trametinib|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Decrease of Exposure to Hypnosedative Drugs in the Elderly Through the Discontinuation of Hospital-initiated Prescription
Status: UNKNOWN
Conditions: Sleep Disorders
Interventions: PROCEDURE: Hypnosedative discontinuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Feeding America's Bravest: Mediterranean Diet-Based Interventions to Change Firefighters' Eating Habits
Status: COMPLETED
Conditions: Diet, Mediterranean|Health Behavior|Program Sustainability|Program Effectiveness
Interventions: BEHAVIORAL: Mediterranean diet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas
Status: COMPLETED
Conditions: Astrocytoma|Oligo-Astrocytoma|Glioma
Interventions: BIOLOGICAL: GAA/TT-peptide vaccine and poly-ICLC|BIOLOGICAL: GAA/TT-peptide vaccine and poly-ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Treatment of Renal Anemia in Dialysis Subjects
Status: COMPLETED
Conditions: Anemia|Renal Insufficiency, Chronic
Interventions: DRUG: Molidustat (BAY85-3934)|DRUG: Darbepoetin alfa|DRUG: Placebo of Molidustat (BAY85-3934)|DRUG: Placebo of Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Autologous Cryopreserved Platelets in Patients With PTR
Status: RECRUITING
Conditions: Platelet Transfusion Refractoriness
Interventions: OTHER: Cryopreserved autologous platelet transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot, Proof-of-Concept Study of Sublingual Tizanidine in Children With Chronic Traumatic Brain Injury (TBI)
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Sublingual Tizanidine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustine Hydrochloride in Treating Patients With Previously Treated Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma|Plasma Cell Leukemia
Interventions: DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bipolar Maintenance Study of Lurasidone Adjunctive to Lithium or Divalproex
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: Lurasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison Between Signature Total Knee Arthroplasty (TKA) to Conventional TKA and Computer Assisted TKA
Status: COMPLETED
Conditions: Joint Disease
Interventions: DEVICE: Signature Knee Guide|DEVICE: Conventional Instrumentation|DEVICE: Computer Assisted Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study Evaluating the Use of SafeBreak Vascular in the Geriatric Trauma Population
Status: COMPLETED
Conditions: IV Dislodgement
Interventions: DEVICE: SafeBreak Vascular
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.
Status: COMPLETED
Conditions: Severe Eosinophilic Asthma|Nasal Polyps
Interventions: OTHER: FASENRA(benralizumab)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 4 Study to Assess the Effects of Aripiprazole Versus Other Atypical Antipsychotics in the Treatment of Schizophrenic Patients With Metabolic Syndrome
Status: TERMINATED
Conditions: Metabolic Syndrome|Schizophrenia
Interventions: DRUG: Aripiprazole|DRUG: Continued Antipsychotic (Risperidone or Quetiapine or Olanzapine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of tDCS as an Adjunct to Outpatient Physiotherapy in Children With ABI
Status: RECRUITING
Conditions: Acquired Brain Injury|Stroke|Traumatic Brain Injury|Hemiparesis
Interventions: DEVICE: active transcranial direct current stimulation|DEVICE: sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Models of Auditory Hallucination
Status: TERMINATED
Conditions: Schizophrenia|Schizo Affective Disorder|Auditory Hallucination
Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Compare the Effectiveness of Two Different Outpatient Endometrial Ablation Techniques Used for Heavy Periods
Status: COMPLETED
Conditions: Menorrhagia
Interventions: DEVICE: NovaSure|DEVICE: thermachoice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Palm And Rice Bran Oil Study
Status: COMPLETED
Conditions: Glucose Response
Interventions: OTHER: Breakfast with rice bran oil gel|OTHER: Breakfast with rice bran oil|OTHER: Breakfast with palm oil gel|OTHER: Breakfast with palm oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome (RLS)|Restless Legs Syndrome
Interventions: DRUG: Ropinirole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Rheumatology Diet Study
Status: RECRUITING
Conditions: Diet Habit|Rheumatologic Disease|Autoimmune Diseases|Rheumatoid Arthritis|Psoriatic Arthritis|Ankylosing Spondylitis|Dermatomyositis/Polymyositis|Sjogren's Syndrome|Systemic Lupus Erythematous|Scleroderma|Fibromyalgia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Clinical Trial Comparing Coronary Bypass Grafting With or Without Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Ischemic Heart Disease
Interventions: PROCEDURE: Coronary bypass surgery without cardiopulmonary bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Lipogems for Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: autologous microfragmented lipoaspirate tissue (Lipogems®).|PROCEDURE: arthroscopic debridment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability of 4 Formulations of Fentanyl Transdermal System Compared Against DUROGESIC Fentanyl Transdermal Patch After Single Application in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Treatment A: DUROGESIC (8.4 mg fentanyl)|DRUG: Treatment B: Transdermal System-Concept 1 (6.2 mg fentanyl)|DRUG: Treatment C: Transdermal System-Concept 2 (6.2 mg fentanyl)|DRUG: Treatment D: Transdermal System-Concept 3 (7.1 mg fentanyl)|DRUG: Treatment E: Transdermal System-Concept 4 (11.0 mg fentanyl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Enhancement Training Study for Experienced Shiftworkers
Status: COMPLETED
Conditions: Shift-Work Sleep Disorder
Interventions: BEHAVIORAL: NIOSH shiftwork booklet|BEHAVIORAL: Sleep Enhancement Training System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts
Status: COMPLETED
Conditions: Child Behavior
Interventions: BEHAVIORAL: Visual Scheduling|BEHAVIORAL: signalling change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of CCX140-B on Urinary Albumin Excretion in Subjects With Type 2 Diabetes and Albuminuria
Status: COMPLETED
Conditions: Diabetic Nephropathy|Type 2 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: CCX140-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Small-gauge Vitrectomy and Conventional Vitrectomy for Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Interventions: PROCEDURE: Vitrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Free α-hemoglobin Pool in the Red Blood Cells : Prognostic Marker and Severity Index in Thalassemic Syndromes
Status: COMPLETED
Conditions: Thalassemic Syndromes
Interventions: OTHER: Free α-Hb pool analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Daratumumab in Patients With Relapsed/Refractory Myeloma With Renal Impairment
Status: COMPLETED
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: DRUG: Daratumumab with dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CardioPROTECTion With Dapagliflozin in Breast Cancer Patients Treated With AnthrAcycline - PROTECTAA TRIAL
Status: RECRUITING
Conditions: Breast Cancer|Heart Failure
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acetyl-L-Carnitine Supplementation During HCV Therapy With Peg IFN-α2b Plus Ribavirin: Effect on Work Performance.
Status: COMPLETED
Conditions: Quality of Life|Daily Activity|Fatigue
Interventions: DRUG: Acetyl-L-carnitine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy
Status: COMPLETED
Conditions: Osteosarcoma|Nephrotoxicity|Ototoxicity
Interventions: DRUG: Pantoprazole|DRUG: High-dose methotrexate infusion duration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Analyse the Effect of Semaglutide on Vascular Structure and Function in Patients With Early Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide Pen Injector|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Arthroscopic Versus Open Surgical Discopexy for Treatment of Temporomandibular Joint Anterior Disc Displacement Without Reduction (RCT)
Status: RECRUITING
Conditions: Efficacy of TMJ Arthroscopy
Interventions: PROCEDURE: TMJ discopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of 1,064-nm Picosecond Laser With Microlens Array for the Treatment of Abdominal Striae Distensae
Status: UNKNOWN
Conditions: Striae Alba
Interventions: DEVICE: fractional picosecond 1,064 nm laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Geriatric Assessment for Frail Older People With Chronic Kidney Disease - The GOAL Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Frailty|Chronic Kidney Diseases
Interventions: OTHER: Comprehensive Geriatric Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Givinostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: dexamethasone|DRUG: asparaginase|DRUG: Asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin|DRUG: doxorubicin|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: mercaptopurine|DRUG: Methotrexate|DRUG: prednisone|DRUG: thioguanine|DRUG: Vincristine|DRUG: Vindesine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium
Status: COMPLETED
Conditions: Delirium|Postoperative Complications|Postoperative Cognitive Dysfunction
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction|Diabetes Mellitus
Interventions: DIAGNOSTIC_TEST: Nitric oxide synthase gene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
Status: TERMINATED
Conditions: Carotid Artery Plaque
Interventions: RADIATION: 99mTc-rhAnnexin V-128
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Silicon-based Formulations on Wound Healing of Laser-induced Microscopic Skin Lesions
Status: COMPLETED
Conditions: Wound Healing
Interventions: DEVICE: Stratacel|DEVICE: Stratamed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Metastatic|mCRC
Interventions: BIOLOGICAL: Aldoxorubicin Hydrochloride|BIOLOGICAL: ALT-803|BIOLOGICAL: ETBX-011|BIOLOGICAL: ETBX-021|BIOLOGICAL: ETBX-051|BIOLOGICAL: ETBX-061|BIOLOGICAL: GI-4000|BIOLOGICAL: GI-6207|BIOLOGICAL: GI-6301|BIOLOGICAL: haNK|DRUG: Avelumab|DRUG: Capecitabine|DRUG: Cetuximab|DRUG: Cyclophosphamide|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Nab-paclitaxel|DRUG: Oxaliplatin|DRUG: Regorafenib|PROCEDURE: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of A New High-speed and High-resolution Intravascular Ultrasound System
Status: COMPLETED
Conditions: Percutaneous Coronary Intervention|Coronary Artery Disease|Chronic Total Occlusion of Coronary Artery|Left Main Coronary Artery Disease
Interventions: DEVICE: Insight Lifetech IVUS System|DEVICE: Boston Scientific IVUS System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brimonidine Eye Drops for Treatment of Ocular Graft-vs-Host Disease (oGVHD)
Status: TERMINATED
Conditions: Dry Eye|Ocular Graft vs Host Disease|Meibomian Gland Dysfunction
Interventions: DRUG: Brimonidine 0.15%|DRUG: Brimonidine 0.075%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Topical TolaSure on Acute Induced Wounds in Healthy Participants
Status: COMPLETED
Conditions: Wound Healing
Interventions: DRUG: TolaSure Topical Gel|DRUG: Topical Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of BPL HRIG With Active Rabies Vaccine in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HRIG|DRUG: HyperRAB|BIOLOGICAL: RabAvert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Methyl-Sulphonyl-Methane on Osteoarthritis and Cartilage
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: MethylSulfonylMethane (MSM)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Test if Fremanezumab is Effective in Preventing Episodic Migraine in Patients 6 to 17 Years of Age
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Fremanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preserving Physical Function in Older Adults With Cancer: Impact of an Optimizing Nutrition Intervention Applied Before and After Surgery
Status: RECRUITING
Conditions: Cancer
Interventions: BEHAVIORAL: Structured perioperative nutrition and exercise|BEHAVIORAL: Nutrition and Exercise Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: BCI Post-stroke Neurorehabilitation
Status: COMPLETED
Conditions: Poststroke/CVA Hemiparesis|Paralytic Stroke|Hand Flaccid Paralysis
Interventions: DEVICE: EEG based Brain Computer Interface
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE