pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of XEN901
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: XEN901|DRUG: Inert Ingredients Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety of HP3070 in Subjects Diagnosed With Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Low Dose Asenapine maleate transdermal patch|DRUG: High Dose Asenapine maleate transdermal patch|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving the Medication Management of Patients With Attention-Deficit Hyperactivity Disorder
Status: WITHDRAWN
Conditions: Attention Deficit-hyperactivity Disorder
Interventions: BEHAVIORAL: Clinical decision support for medication titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The ONE-MIND Study: Evaluating the Efficacy of Online Mindfulness-Based Cancer Recovery During Chemotherapy Treatment
Status: RECRUITING
Conditions: Breast Cancer|Colorectal Cancer|Chemotherapy Effect
Interventions: BEHAVIORAL: Online Mindfulness Based Cancer Recovery (MBCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Progel Sealant to Standard of Care (SOC) for Patients Undergoing Decortication
Status: WITHDRAWN
Conditions: Lung Diseases|Mesothelioma
Interventions: OTHER: Progel Sealant|OTHER: Talcum Powder|BEHAVIORAL: Pain Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ginger Extract (Compare Between the Ginger Preparation of Ancient Concept of Thai Traditional Practitioner, Standard Drug and Placebo) by Using Pain Score to Evaluate After Pain of Three Groups of First Normal Postpartum Women.
Status: COMPLETED
Conditions: Postpartum Disorder
Interventions: DRUG: Ginger|DRUG: Placebo oral capsule|DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Stability After Implantation of Two Different Lens Models: FEMTIS-study
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: FEMTIS 313G IOL|DEVICE: Acrysof SN60WF IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of NMS-03592088 in Patients With Relapsed or Refractory AML or CMML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|Chronic Myelomonocytic Leukemia (CMML)
Interventions: DRUG: NMS-03592088
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Phase 2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF)
Status: RECRUITING
Conditions: Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-Essential Thrombocytosis Myelofibrosis
Interventions: DRUG: Ruxolitinib|DRUG: Tasquinimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Image Guided Stereotactic Ablative Radiotherapy for Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: RADIATION: Image Guided Stereotactic Ablative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone as a Model for Reversible Activation of Adipose Tissue Fibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibrosis
Interventions: BIOLOGICAL: Growth hormone, saline and GH receptor blockade (Pegvisomant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DEVICE: Endoscopy (FICE and pCLE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessment of Response Before, During and After Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma|Rectal Neoplasms
Interventions: OTHER: 18F- FDG PET scans|OTHER: DW-MRI scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: Triamcinolone Acetonide + laser|DRUG: Ranibizumab + laser|DRUG: Sham injection + laser|DRUG: Ranibizumab + deferred laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Immunogenicity of Poly ICLC (Hiltonol) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Hiltonol (poly ICLC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Trial To Assess Fesoterodine On Treatment Satisfaction And Symptom Improvement In Overactive Bladder Patients
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: fesoterodine fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Plasma Metabolomics Profiling of Primary Aldosteronism
Status: COMPLETED
Conditions: Primary Aldosteronism|Essential Hypertension|Idiopathic Aldosteronism|Aldosterone-producing Adenoma
Interventions: DIAGNOSTIC_TEST: liquid chromatography-mass spectrometry (LC/MS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Follow-up of Patients With Multivessel Coronary Artery Disease After CABG
Status: UNKNOWN
Conditions: Coronary (Artery); Disease
Interventions: OTHER: Myocardial Perfusion Scan|OTHER: Coronary CTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: RC48 Combined With EGFR or HER2 TKI for Locally Advanced or Metastatic NSCLC Patients With HER2 Alterations
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|ERBB2 Mutation-Related Tumors|ERBB2 Gene Duplication|Disitamab Vedotin
Interventions: DRUG: Disitamab Vedotin|DRUG: third-generation EGFR TKIs (Almonertinib/Furmonertinib/Osimertinib)|DRUG: pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
Status: COMPLETED
Conditions: Chest Pain|Acute Coronary Syndrome|Acute Myocardial Infarction|Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: CT Coronary Angiography (CTCA)|PROCEDURE: Traditional Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Lutetium-177-PSMA Radioligand Therapy in Advanced Salivary Gland Cancer Patients
Status: COMPLETED
Conditions: Salivary Gland Cancer|Salivary Duct Carcinoma|Adenoid Cystic Carcinoma
Interventions: DRUG: Lutetium-177-PSMA-I&T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Silicone-based vs. B-Lite® Light Weight Breast Implant After Total Mastectomy and Radiotherapy for Breast Cancer
Status: COMPLETED
Conditions: Breast Implant; Complications|Breast Implant Protrusion|Breast Cancer|Radiotherapy Side Effect
Interventions: DEVICE: B-Lite® light weight breast implant|DEVICE: Standard silicone-based breast implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: First in Human Safety Study of FX-345 in Adults With Sensorineural Hearing Loss
Status: TERMINATED
Conditions: Hearing Loss, Sensorineural
Interventions: DRUG: FX-345|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of Imiglucerase Treatment in Chinese Patients With Gaucher Disease Type Ⅲ
Status: COMPLETED
Conditions: Gaucher's Disease
Interventions: DRUG: Cerezyme® / Imiglucerase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection
Status: TERMINATED
Conditions: Brain Metastases
Interventions: RADIATION: intraoperative radiotherapy (IORT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Convulsive Therapies for Bipolar Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Bipolar Disorder|Bipolar Depression|Bipolar I Disorder|Bipolar II Disorder
Interventions: DEVICE: Magnetic Seizure Therapy (MST)|DEVICE: Electroconvulsive Therapy (ECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Prospective, Randomized, Multi-center, Phase II Comparative Trial of Thymoglobulin Versus Simulect for the Prevention of Delayed Graft Function and Acute Allograft Rejection in Renal Allograft Recipients.
Status: COMPLETED
Conditions: Cadaveric Donor Renal Transplantation|Acute Renal Allograft Rejection|Induction Therapy
Interventions: BIOLOGICAL: Thymoglobulin [Anti-thymocyte Globulin (rabbit)]|DRUG: Simulect (basliximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Long-term Follow up Helicobacter Pylori Reinfection Rate After Second-Line Treatment: Bismuth-Containing Quadruple Therapy Versus Moxifloxacin-Based Triple Therapy
Status: COMPLETED
Conditions: Helicobacter Infections
Interventions: DRUG: esomeprazole|DRUG: tripotassium dicitrate bismuthate|DRUG: metronidazole|DRUG: tetracycline|DRUG: moxifloxacin|DRUG: amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Open-label, Single-arm, Phase II Study of NHWD-870 HCl in Adults and Adolescents With Advanced NUT Cancer
Status: RECRUITING
Conditions: Patients With Advanced NUT Cancer
Interventions: DRUG: NHWD-870 HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bufei Jianpi Granule for Delaying Pulmonary Function Decline in Early-Stage COPD
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Bufei Jianpi granule|DRUG: Placebo Bufei Jianpi granule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Skin Microbiome in Graft Versus Host Disease
Status: RECRUITING
Conditions: Skin Microbiome|Graft Versus Host Disease|Graft Versus Host Disease in Skin
Interventions: DIAGNOSTIC_TEST: Skin swabs|DIAGNOSTIC_TEST: Skin punch biopsies|DIAGNOSTIC_TEST: additional blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Evaluation and Antimicrobial Effect of Papain Based Chemo-mechanical Caries Removal Agents
Status: RECRUITING
Conditions: Dental Caries
Interventions: PROCEDURE: BRIX3000|PROCEDURE: papacarie|PROCEDURE: hand excavation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of Lebrikizumab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Lebrikizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of IgAN With Multi-glycoside of Tripterygium Wilfordii HOOK. f.
Status: UNKNOWN
Conditions: IgA Nephropathy
Interventions: DRUG: Multi-glycoside of Tripterygium Wilfordii HOOK. f. (TWH)|DRUG: Mycophenolate mofetil (MMF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Redesign of Everyday Activities and Lifestyle With Occupational Therapy for Chronic Pain Patients
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Lifestyle-oriented Occupational Therapy added to current treatment of chronic non-malignant pain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Trial, Evaluating the Long-term Safety and Tolerability of Brivaracetam Will Provide Subjects Suffering From Epilepsy, Who May Have Benefited From Brivaracetam as Adjunctive Treatment, the Opportunity to Receive Open Label Brivaracetam Treatment
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Labetalol vs Phentolamine for the Management of Severe Preeclampsia.
Status: NOT_YET_RECRUITING
Conditions: Severe Pre-eclampsia
Interventions: DRUG: Labetalol|DRUG: Phentolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Influence of Variations in Systemic Blood Flow and Blood Pressure on Cerebral Oxygenation Measured by Cerebral Oximetry
Status: COMPLETED
Conditions: Cerebral Oxygen Saturation
Interventions: DEVICE: A disposable NIRS (near-infrared spectroscopy) sensor will be applied on the patient's forehead for continuous registration of the cerebral oxygen saturation.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Liposomal Mitoxantrone Hydrochloride Injection,Cyclophosphamide, Vincristine and Prednisone in the Treatment of PTCL
Status: TERMINATED
Conditions: Treatment-naïve|Peripheral T Cell Lymphoma
Interventions: DRUG: Dose-finding stage: Liposomal mitoxantrone hydrochloride, Cyclophosphamide, Vincristine and Prednisone|DRUG: Dose-expansion stage: Liposomal mitoxantrone hydrochloride, Cyclophosphamide, Vincristine and Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ingavirin®, Capsules, 60 mg, in Children With Influenza and Other Acute Respiratory Viral Infections
Status: RECRUITING
Conditions: Influenza, Human|Acute Respiratory Infection|Common Cold
Interventions: DRUG: Ingavirin®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebellar rTMS Theta Burst for Dual-task Walking in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson|Parkinson Disease|Gait Disorders, Neurologic|Parkinsonism|Gait, Festinating
Interventions: DEVICE: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Fluid Therapy on Postoperative Vomiting in Children Undergoing Otorhinolaryngological Surgery
Status: COMPLETED
Conditions: Postoperative Vomiting
Interventions: OTHER: Intraoperative lactated Ringer's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fully Automated Scan Technique Optimisation of Scan Timing in Chest CT
Status: TERMINATED
Conditions: Pulmonary Disease
Interventions: OTHER: FAST start software delay|OTHER: Manual bolus tracking delay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Advances in Treatment: Examining the Effectiveness of a Behavioral Intervention.
Status: UNKNOWN
Conditions: Psychosocial Problems
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Nirmatrelvir/Ritonavir for Treating Omicron Variant of COVID-19
Status: COMPLETED
Conditions: Omicron Variant of COVID-19
Interventions: DRUG: Nirmatrelvir/Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of LAVA-1207 in Patients With Therapy Refractory Metastatic Castration Resistant Prostate Cancer (mCRPC) Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: BIOLOGICAL: LAVA-1207|BIOLOGICAL: LAVA-1207 plus Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Methoxsalen|PROCEDURE: Extracorporeal Photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Vulvovaginal Candidiasis
Interventions: DRUG: Terconazole Vaginal Suppository|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel
Status: TERMINATED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: ProDisc™-L Total Disc Replacement (TDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Evaluation of Energy Expenditure in ICU Patients From Admission to Discharge Using A Novel Indirect Calorimeter: LEEP-Forward Trial
Status: WITHDRAWN
Conditions: Metabolism Requirement|Energy Requirement|Indirect Calorimetry
Interventions: DEVICE: Q-NRG Metobolic Cart Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Shave Margins in Breast Conservation Therapy
Status: TERMINATED
Conditions: Breast Cancer|Cancer of Breast|Cancer of the Breast
Interventions: PROCEDURE: Breast-conserving surgery (BCS)|PROCEDURE: Cavity shave margins (CSM)|BEHAVIORAL: BREAST-Q Questionnaire|DEVICE: 3-D breast imaging|OTHER: Indocyanine green|DEVICE: Intraoperative imaging device|PROCEDURE: Peripheral blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Flu Vaccine Study in Neuromuscular Patients 2011
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy|Spinal Muscular Atrophy|Congenital Muscular Dystrophy
Interventions: BIOLOGICAL: 2011-2012 seasonal flu vaccine Subcutaneous|BIOLOGICAL: 2011-2012 seasonal flu vaccine Intramuscular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program
Status: RECRUITING
Conditions: Substance-Related Disorders|Adverse Childhood Experiences
Interventions: BEHAVIORAL: Strengthening Families Program + Family Advocate|BEHAVIORAL: Strengthening Families Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Brugger's Exercise With and Without Kendall Exercises in Sterno-Symphyseal Syndrome
Status: RECRUITING
Conditions: Upper Crossed Syndrome
Interventions: PROCEDURE: Brugger's exercise.|PROCEDURE: Kendall Exercise.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rheopheresis as Adjuvant Treatment of Calciphylaxis
Status: ENROLLING_BY_INVITATION
Conditions: Metabolic Disorder|End Stage Renal Disease|Rare Diseases
Interventions: PROCEDURE: Rheopheresis procedure|PROCEDURE: Sham-apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Prenatal/Early Infancy Project: An Adolescent Follow-up
Status: COMPLETED
Conditions: Behavior, Adaptive
Interventions: BEHAVIORAL: Developmental Screening|BEHAVIORAL: Screening plus Transportation|BEHAVIORAL: Screening, Transport, Prenatal Visits|BEHAVIORAL: Screen, Transport, Prenatal/Inf Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes
Status: COMPLETED
Conditions: Heart Transplant Surgery|Lung Transplant Surgery
Interventions: DRUG: iNO|DRUG: iEPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Multiple Dose Study of the Safety and Pharmacokinetics of NTRX-07
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: NTRX-07|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Feedback on Physical Activity Surveillance Using Wearable Device-Smartphone Application for Resolution of Metabolic Syndrome in Aged 60 or Older
Status: COMPLETED
Conditions: Metabolic Syndrome|Physical Activity|Wearable Device
Interventions: OTHER: Receving feedback|OTHER: No regular feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intraperitoneal Paclitaxel, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Stage III-IV Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenosquamous Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Mixed Adenocarcinoma|Endometrial Serous Adenocarcinoma|Endometrial Squamous Cell Carcinoma|Endometrial Undifferentiated Carcinoma|Recurrent Uterine Corpus Carcinoma|Stage IIIA Uterine Corpus Cancer|Stage IIIC Uterine Corpus Cancer|Stage IVA Uterine Corpus Cancer|Stage IVB Uterine Corpus Cancer
Interventions: DRUG: Cisplatin|DRUG: Doxorubicin Hydrochloride|BIOLOGICAL: Filgrastim|DRUG: Paclitaxel|BIOLOGICAL: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Photobiomodulation for Reducing Autism Symptoms in Children
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Cognilum TM: Light Treatment Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndrome|Myelodysplastic Syndrome|Secondary Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine (AZC)|DRUG: Decitabine|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Trifluridine/Tipiracil Plus an Anti-IL-1α True Human Antibody Versus Trifluridine/Tipiracil Plus Placebo in Metastatic Colorectal Cancer Patients After Failure of Oxaliplatin, Irinotecan, Fluoropyrimidine
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: trifluridine/tipiracil + XB2001|DRUG: trifluridine/tipiracil + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: single anaesthetic drug|DRUG: multimodal drug injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
Status: COMPLETED
Conditions: End-stage Renal Disease
Interventions: OTHER: high dialysate sodium concentration (138 mEq/L)|OTHER: Low dialysate sodium concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine Sulfate for Reduction of Proteinuria in Patients With IgA Nephropathy: a Self- Controlled Study
Status: COMPLETED
Conditions: Primary IgA Nephropathy
Interventions: DRUG: Hydroxychloroquine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block to Augment Trauma-focused Therapy Among Veterans With PTSD
Status: ACTIVE_NOT_RECRUITING
Conditions: PTSD|Trauma and Stressor Related Disorders|Trauma, Psychological|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Processing Therapy (CPT)|DRUG: Stellate Ganglion Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: Intermittent theta-burst stimulation (iTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paroxetine-mediated GRK2 Inhibition to Reduce Cardiac Remodeling After Acute Myocardial Infarction
Status: COMPLETED
Conditions: Cardiac Remodeling|Myocardial Infarction
Interventions: DRUG: Paroxetine|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma|Mesothelioma, Malignant|Mesothelioma; Pleura|Mesotheliomas Pleural|Mesothelioma Peritoneum|Cholangiocarcinoma|Cholangiocarcinoma Recurrent|Ovarian Cancer|Non Small Cell Lung Cancer|Non Small Cell Lung Cancer Metastatic|High Grade Ovarian Serous Adenocarcinoma
Interventions: BIOLOGICAL: gavo-cel|DRUG: fludarabine|DRUG: cyclophosphamide|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient
Status: WITHDRAWN
Conditions: Liver Transplant; Complications|Ischemia Reperfusion Injury
Interventions: PROCEDURE: remote ischemic preconditioning (rIC)|OTHER: non remote ischemic preconditioning (non-rIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mini-trampoline Intervention vs. Nordic Walking: Balance, Fitness and Neuropsychological Effects
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: OTHER: mini-trampoline|OTHER: Nordic Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Japanese Phase 1 Multiple Ascending Dose (MAD) Study
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: BMS-820836|DRUG: BMS-820836|DRUG: BMS-820836|DRUG: Placebo matching BMS-820836|DRUG: BMS-820836
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Three Insulin Protocols in Medical Intensive Care Unit Patients
Status: COMPLETED
Conditions: Intensive Care
Interventions: PROCEDURE: Computer-assisted IV insulin infusion protocol (algorithm A)|PROCEDURE: Leuven Strict glycemic control protocol (Algorithm B)|PROCEDURE: Conventional Intermittent Insulin Protocol (Algorithm C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Atkinson Product Design Urinary Slide Valve Versus Standard Catheter Drainage System on Social Functioning
Status: WITHDRAWN
Conditions: Urinary Catheterization|Urinary Tract Infections
Interventions: DEVICE: Truvalve|OTHER: Control (catheter drainage bag)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Anti-CD38 Antibody Treating APS With Thrombocytopenia
Status: RECRUITING
Conditions: Antiphospholipid Syndrome|Thrombocytopenia
Interventions: DRUG: Anti-CD38 antibody Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Achieving My Potential: A Randomized, Controlled Trial of a Telephone-Based Developmental Care Coordination System
Status: COMPLETED
Conditions: Child Development|Health Services Research
Interventions: BEHAVIORAL: Telephone-based early childhood developmental care coordination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Status: COMPLETED
Conditions: Cushing's Syndrome|Pituitary Adenoma|Carney Complex|Primary Pigmented Nodular Adrenocortical Disease|Peutz-Jeghers Syndrome
Interventions: DRUG: oCRH
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Effect of the VR Technology on Recovery of the Autonomic Nervous System in Volunteers Affected by Stress
Status: COMPLETED
Conditions: Stress
Interventions: DEVICE: Pure Purr VR technology|DEVICE: Sham VR technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?
Status: COMPLETED
Conditions: Ischemia Reperfusion Injury
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Written Dietary Advice on Lipoproteins - a Pragmatic Randomized Controlled Trial
Status: COMPLETED
Conditions: Cholesterol, LDL
Interventions: OTHER: Written advice LDL Cholesterol|OTHER: Written advice Triglycerides
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 6xFU/Epirubicin/Cyclophosphamide (FEC) Compared to 3xFEC-3xDocetaxel in High-risk Node-negative Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: 5-Fluorouracil, Epirubicin, Cyclophosphamide, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CS1001 in Subjects With Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Unresectable Locally Advanced, Recurrent or Metastatic Esophageal Squamous Cell Carcinoma
Interventions: DRUG: CS1001+ Fluorouracil+Cisplatin|DRUG: Placebo+ Fluorouracil+Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Buprenorphine transdermal delivery system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vildagliptin add-on to Glimepiride Versus Placebo Added to Glimepiride in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding
Status: COMPLETED
Conditions: Esophageal Varices|Bleeding
Interventions: DRUG: pantoloc 40 mg|DRUG: somatostatin or terlipressin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Amlodipine Besylate and Candesartan Cilexetil in Essential Hypertension Patient Who Are Not Adequately Controlled With Candesartan Cilexetil Monotherapy
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Candesartan cilexetil 16mg|DRUG: Amlodipine 10mg, Candesartan cilexetil 16mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Virtual Reality Glasses Pain, Anxiety and Satisfaction Level in Intrauterine Device Application'
Status: RECRUITING
Conditions: Virtual Reality|Pain|Anxiety|Distraction Cards
Interventions: DEVICE: Virtual Reality (VR) Group|DEVICE: Group using distraction cards
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis
Status: NOT_YET_RECRUITING
Conditions: Prurigo Nodularis
Interventions: DRUG: Povorcitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ameliorating Contrast Induced Nephropathy After Coronary Angiography
Status: COMPLETED
Conditions: Coronary Artery Disease|Nephropathy; Toxic, Drugs
Interventions: DRUG: Atorvastatin 80mg|DRUG: N-acetyl cysteine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of ASTARTE™ on Recurrent Urinary Tract Infection
Status: RECRUITING
Conditions: Recurrent Urinary Tract Infection
Interventions: DIETARY_SUPPLEMENT: ASTARTE™ oral capsules|DIETARY_SUPPLEMENT: Placebo oral capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Interest to Combine a CD4 Th1-inducer Cancer Vaccine Derived From Telomerase and Atezolizumab Plus Bevacizumab in Unresectable Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|DRUG: UCPVax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Single Dose of Wild Blueberries on Mood and Executive Function in Healthy Emerging Adults
Status: RECRUITING
Conditions: Mood|Affect|Executive Function
Interventions: DIETARY_SUPPLEMENT: Blueberry drink|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acceptability and Feasibility of a New Postural Management Night-time Intervention to Improve Respiratory Health of Children With Complex Neuro-disability
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Aspiration
Interventions: OTHER: Novel Postural Management Night-time Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Examination of the Metabolic Effects of Direct Bile Salt Delivery to the Ileum in Humans
Status: TERMINATED
Conditions: Glucose Intolerance|Gastric Bypass Surgery
Interventions: DRUG: Ursodeoxycholic Acid|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess Safety, Tolerability and Phamacokinetics of KAE609 Administered Intravenously in Healthy Subjects
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: KAE609|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of the Microbiome on Time to Pregnancy and Pregnancy Outcomes in Fertile Women Attempting to Conceive
Status: RECRUITING
Conditions: Pregnancy Complications|Contraception|Pregnancy Loss|Fertility|Microbial Colonization|Metabolome
Interventions: DIAGNOSTIC_TEST: Vaginal and rectal microbiome and metabolome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Double-Blinded, Placebo-Controlled Study of Sorafenib in Patients With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Sorafenib (Nexavar, BAY43-9006)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Profile of 'Blackadder' Blackcurrant Juice Effects Upon the Monoamine Axis in Humans
Status: COMPLETED
Conditions: Monoamine Oxidase Inhibitor Activity|Prolactin Levels|Postprandial Blood Glucose
Interventions: DIETARY_SUPPLEMENT: Blackadder Juice|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial Testing the Effect of Strategies on Performance of Brief Intervention Programmes for Harmful Alcohol Consumption
Status: COMPLETED
Conditions: Alcoholism
Interventions: OTHER: Training and support (T&S)|OTHER: Financial incentive|OTHER: E-SBI (online screening and brief intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Neoadjuvant TAK-700 and Leuprorelin Acetate Followed by Surgery Versus Surgery Alone
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: TAK-700 and LHRH agonist|PROCEDURE: prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Meloxicam 2 x 7.5 mg Tablets Compared to 15 mg Tablet and Dose Proportionality Over a Dose Range of 7.5 mg and 15 mg in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Treatment 1|DRUG: Treatment 2|DRUG: Treatment 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Matrilysin Expression in Different Stages of Colorectal Tumors
Status: COMPLETED
Conditions: Colorectal Cancer Stage 0|Colorectal Cancer Stage I|Colorectal Cancer Stage II|Colorectal Cancer Stage III|Colorectal Cancer Stage IV
Interventions: PROCEDURE: colonic or colorectal resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Intravascular Ultrasound(IVUS)-Guided Chronic Total Occlusion Intervention With Drug-eluting Stents
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Non-IVUS guided intervention with Endeavor Resolute stent (zotarolimus-eluting stent, Medtronic)|DEVICE: IVUS guided intervention with Endeavor Resolute stent (zotarolimus-eluting stent, Medtronic)|DEVICE: Non-IVUS guided intervention with Nobori stent (biolimus A9-eluting stent, Terumo)|DEVICE: IVUS guided intervention with Nobori stent (biolimus A9-eluting stent, Terumo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-CGRP for Inflamation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia
Status: COMPLETED
Conditions: Trigeminal Neuralgia|Glossopharyngeal Neuralgia
Interventions: DRUG: Galcanezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Life Success Through Residential Immersive Life Skills (RILS) Programs for Youth With Disabilities
Status: COMPLETED
Conditions: Child-onset Disability
Interventions: BEHAVIORAL: Residential Immersive Life Skills programming|BEHAVIORAL: Non-residential life skills programming
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Three Measures for the Prevention of Carious Lesions in Preschool Children
Status: UNKNOWN
Conditions: Dental Caries
Interventions: DRUG: fluoride varnish|BIOLOGICAL: Immunoglobulin Yolk|DIETARY_SUPPLEMENT: Probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis
Status: UNKNOWN
Conditions: Non-Traumatic Osteonecrosis
Interventions: DRUG: Alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: The Exploreration of the Management for the Positive IAA in Patients With Type 2 Diabetes After Premix Insulin Therapy
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: Add oral hyppoglycemia drug|OTHER: Add GLP-1 receptor agonist|OTHER: Change insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Health Effects of High Temperature Exposure
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular System|Respiratory System|Cognitive Function
Interventions: OTHER: high temperature (32℃) group|OTHER: moderate temperature (22℃) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of TQB2450 Injection Plus Chemotherapy Followed by TQB2450 Plus Anlotinib Versus Tislelizumab Plus Chemotherapy Followed by Tislelizumab in the Treatment of First-line Non-squamous Non-small Cell Lung Cancer(NSCLC).
Status: UNKNOWN
Conditions: Advanced Non-squamous Non-small Cell Lung Cancer
Interventions: DRUG: TQB2450 injection, Tilelizumab injection, Anlotinib hydrochloride capsule, Pemetrexed disodium injection, Carboplatin injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT