pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Plasma Appearance of Xanthohumol in Healthy Adults
Status: COMPLETED
Conditions: Plasmakinetics of Xanthohumol
Interventions: DIETARY_SUPPLEMENT: solubilized Xanthohumol low dose|DIETARY_SUPPLEMENT: solubilized Xanthohumol high dose|DIETARY_SUPPLEMENT: native Xanthohumol low dose|DIETARY_SUPPLEMENT: native Xanthohumol high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Glycemic Control Using a Virtual Weight Control Program and Continuous Glucose Monitoring
Status: RECRUITING
Conditions: Diabetes Mellitus|Type 2 Diabetes|Obesity
Interventions: BEHAVIORAL: WW Intervention|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proximal Versus Distal Adductor Canal Blocks for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Post-Operative Pain
Interventions: PROCEDURE: Proximal Adductor Canal Block|PROCEDURE: Distal Adductor Canal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rumination Focus Cognitive Behavior Therapy
Status: UNKNOWN
Conditions: Depression|Dysthymic Disorder|Panic Disorder|Social Phobia|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Rumination-Focused CBT (RFCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-definition Surface Electromyography Markers for the Diagnosis of Sarcopenia
Status: RECRUITING
Conditions: Sarcopenia
Interventions: OTHER: HD-sEMG|OTHER: - Quadriceps muscle ultrasound|OTHER: IPAQ Physical Activity Questionnaire.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Therapeutic Options for Treatment of Burning Mouth Syndrome
Status: COMPLETED
Conditions: Burning Mouth Syndrome
Interventions: DIETARY_SUPPLEMENT: BioGaia Prodentis lozenges|PROCEDURE: low level laser treatment with Ga-Al-As laser|DIETARY_SUPPLEMENT: B vitamin injections (Neurobion, Merck, Darmstadt, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double or Single Dose Sirolimus-Eluting Stents in Diabetic Patients With de Novo Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: CYPHER Sirolimus-Eluting Coronary Stent|DEVICE: CYPHER Sirolimus-Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Controlled Regional Analgesia Following Carpal Tunnel Release: A Double-Blind Study Using Distal Perineural Catheters
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Ropivacaine 0.2%|DRUG: Ropivacaine 0.75%|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation and Capsulotomy for the Treatment of Refractory Anorexia Nervosa
Status: UNKNOWN
Conditions: Anorexia
Interventions: PROCEDURE: Deep Brain Stimulation(DBS)|PROCEDURE: Capsulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on Heart-rate Corrected QT(QTc) Interval Prolongation During Robotic-assisted Laparoscopic Radical Prostatectomy -Randomized Blind Clinical Trial-
Status: COMPLETED
Conditions: Prostate Cancer|Robotic Surgery
Interventions: DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of NG-641 in Combination With Nivolumab in Metastatic or Advanced Epithelial Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Cancer|Epithelial Tumor
Interventions: BIOLOGICAL: NG-641 in combination with Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Dexamethasone - Cyclodextrin Microparticle Eye Drops for Diabetic Macular Edema
Status: UNKNOWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: dexamethasone - Cyclodextrin eye drops|OTHER: intravitreal Avastin injection +/- macular laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Megavec 400 mg (Imatinib Mesylate) in Healthy Adult Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Megavec|DRUG: Glivec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chemosensitivity Testing to Assign Treatment for Patients With Stage III or Stage IV Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: in vitro sensitivity-directed chemotherapy|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Side Effects of Mandibular Advancement Devices
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome|Temporomandibular Disorders
Interventions: DEVICE: H-MAD with a hinge system according to Herbst
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Examine Sleep and Fatigue in Pediatric Brain Tumor Patients Hospitalized for High Dose Chemotherapy
Status: COMPLETED
Conditions: Sleep|Fatigue
Interventions: OTHER: Sleep Environment Intervention|OTHER: Normal Hospital Environment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Domperidone 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Foot Reflexology in Ocular Hypertensive and Glaucoma Patients
Status: COMPLETED
Conditions: Ocular Hypertension|Glaucoma
Interventions: DEVICE: Massage|PROCEDURE: Experimental insert|PROCEDURE: Sham insert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Liver Transplantation for Non-Resectable Intrahepatic Cholangiocarcinoma: a Prospective Exploratory Trial (TESLA Trial)
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: PROCEDURE: Liver Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Medical Taping Concept in Cancer Patients
Status: UNKNOWN
Conditions: Cancer-related Problem/Condition
Interventions: DEVICE: Cure Tape™ covering T 7 and T 8 dermatomes|DEVICE: Cure Tape™ away from dermatomes T 7 and T 8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low vs. Standard Dose CT for Appendicitis Trial
Status: COMPLETED
Conditions: Appendicitis
Interventions: DIAGNOSTIC_TEST: Diagnostic CT with low-dose radiation|DIAGNOSTIC_TEST: Diagnostic CT with standard-dose radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: To Study the Effect of Sevoflurane and Propofol V Sevoflurane and Dexmedetomidine on Postoperative Cognitive Dysfunction
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: Maintainance of anesthesia with Intravenous Propofol infusion|DRUG: Maintainance of anesthesia with Intravenous Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: TAS-102 in Extrapulmonary Neuroendocrine Carcinoma
Status: UNKNOWN
Conditions: High-grade Extra Pulmonary Neuroendocrine Cancer
Interventions: DRUG: All patients- TAS-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confocal Endomicroscopy for Improved Diagnosis of Barrett's Esophagus and Early Esophageal Cancer(CEBE Study)
Status: COMPLETED
Conditions: Barrett's Esophagus, Esophageal Intraepithelial Neoplasia
Interventions: PROCEDURE: endomicroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Direct Factor Xa Inhibitor YM150 for Prevention of Stroke in Subjects With Non-Valvular Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: YM150|DRUG: warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study of TQA3605 Tablets Monotherapy or in Combination With Nucleoside (Acid) Analogues in Treatment Naive and Treated Patients With Chronic Hepatitis B
Status: RECRUITING
Conditions: Chronic Hepatitis b
Interventions: DRUG: Placebo|DRUG: TQA3605 tablets|DRUG: Entecavir dispersible tablets|DRUG: Tenofovir disoproxil fumarate tablet|DRUG: Tenofovir alafenamide fumarate tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Bubble Continuous Positive Airway Pressure in Reducing Respiratory Distress in Children With Bronchiolitis
Status: UNKNOWN
Conditions: Bronchiolitis Acute Viral|Bronchiolitis|Bronchiolitis Acute|Bronchiolitis, Viral|Nasal Continuous Positive Airway Pressure
Interventions: DEVICE: nasal continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude.
Status: ACTIVE_NOT_RECRUITING
Conditions: Altitude Hypoxia
Interventions: DRUG: ACETAZOLAMIDE oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Two Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies
Status: RECRUITING
Conditions: Breast Cancer|Cardiotoxicity|Cardiovascular Diseases
Interventions: BEHAVIORAL: High Intensity Interval Exercise|BEHAVIORAL: Moderate Intensity Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pelvic Floor Muscle Training on Urinary Incontinence Symptoms and Quality of Life in Women Who Practice Physical Exercise
Status: UNKNOWN
Conditions: Urinary Incontinence|Pelvic Floor Disorders|Quality of Life
Interventions: OTHER: PFMT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Closed Loop Insulin Delivery System in Hypoglycemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Type1diabetes|Hypoglycemia Unawareness|Nocturnal Hypoglycemia|Hypoglycemia Night|Hypoglycemia
Interventions: DEVICE: MiniMed 670G system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Low-level Laser Therapy in the Treatment of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Diabetic Foot
Interventions: DEVICE: LG1|DEVICE: LG2|DEVICE: LG3|DEVICE: CC|PROCEDURE: Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacodynamics of IONIS-DGAT2Rx in Adult Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Hepatic Steatosis
Interventions: DRUG: IONIS DGAT2Rx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: THromboprophylaxis In Sickle Cell Disease With Central Venous Catheters (THIS)
Status: RECRUITING
Conditions: Sickle Cell Disease|Central Venous Catheter Thrombosis|Venous Thromboembolism
Interventions: DRUG: Rivaroxaban 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Etelcalcetide to Treat Secondary Hyperparathyroidism in Hemodialysis Patients With Chronic Kidney Disease-Mineral and Bone Disorder
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: Etelcalcetide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of SAR153191 (REGN88) With Methotrexate in Patients With Active Rheumatoid Arthritis Who Failed TNF-α Blockers
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Sarilumab|DRUG: Placebo|DRUG: Golimumab|DRUG: methotrexate (MTX)|DRUG: Folic/folinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EPC by Intracoronary Injection in Patients With Chronic Stable Angina
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: VesCell (TM)-Autologous EPCs/Angiogenic Cell Precursors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction
Status: RECRUITING
Conditions: Nicotine Dependence|Nicotine Addiction
Interventions: DRUG: n-acetylcysteine|BEHAVIORAL: Motivational Enhancement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgicel and Analgesic Reservoir
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: "Local Anesthetic", "Epinephrine" and "Morphine"|DRUG: "Local Anesthetic", "Epinephrine", "Morphine" and "Surgicel"|DRUG: "Normal Saline"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy
Status: RECRUITING
Conditions: Brain Cancer|Head and Neck Cancer|Lung Cancer|Gastric Cancer|Ovarian Cancer|Colon Cancer
Interventions: DEVICE: Halcyon 4.0 system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate the Effects of Rifampin on Pharmacokinetics (PK) of Pevonedistat in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Neoplasm
Interventions: DRUG: Pevonedistat|DRUG: Rifampin|DRUG: Docetaxel|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms
Status: COMPLETED
Conditions: Gastrointestinal Symptoms
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium lactis HN019|DIETARY_SUPPLEMENT: Bifidobacterium lactis HN019|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vibration Impact on Parkinson's Tremor
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: RMBand lower dose|DEVICE: RMBand higher dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CT Perfusion Scans for Assessment of Lung Cancer Before and After Chemo +/- Radiotherapy
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: PROCEDURE: contrast-enhanced dynamic CT perfusion study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oropharyngeal Administration Of Colostrum For Preventing Necrotizing Enterocolitis in Preterrms
Status: COMPLETED
Conditions: Prematurity
Interventions: OTHER: : Oropharyngeal Administration Of Colostrum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Perifosine in Treating Patients With Recurrent Prostate Cancer
Status: TERMINATED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: perifosine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Salivary Level of miR-155 and IL-10 in Oral Lichen Planus Patients Before and After Treatment With Topical Corticosteroid
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DRUG: Triamcinolone Acetonide in orabase
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The BEET Diabetes Feasibility Trial
Status: ENROLLING_BY_INVITATION
Conditions: Disordered Eating Behaviors
Interventions: BEHAVIORAL: The BEET Diabetes Program|BEHAVIORAL: Cognitive Behavioral Therapy Guided Self-Help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of 5-fluorouracil and Low Molecular Weight Heparin in High-risk Pediatric Retinal Detachment
Status: COMPLETED
Conditions: Retinal Detachment|Proliferative Vitreoretinopathy
Interventions: DRUG: Intraoperative infusion of 5-FU (200 µg/ml) and LMWH (5 IU/ml)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Prednisone Taper Versus Placebo for the Treatment of Acute Relapses in Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Prednisone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AK104 Plus Concurrent Chemoradiation Therapy in Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|B Acute Lymphoblastic Leukemia|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|BIOLOGICAL: Blinatumomab|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Computed Tomography|DRUG: Dasatinib|PROCEDURE: Echocardiography|PROCEDURE: Lumbar Puncture|PROCEDURE: Magnetic Resonance Imaging|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Methotrexate Sodium|DRUG: Prednisone|DRUG: Vincristine|DRUG: Vincristine Sulfate|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation
Status: UNKNOWN
Conditions: Nicotine Dependence|Vaping|Smoking
Interventions: BEHAVIORAL: Use of nicotine product (smoking/vaping)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Demonstrate the Equivalence of the Tofacitinib Oral Solution to the Tablet Formulation in Healthy Participants.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tofacitinib tablet|DRUG: Tofacitinib Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study Assessing Iron Sucrose or Venofer® in Healthy Adult Subjects
Status: COMPLETED
Conditions: Bioequivalance
Interventions: DRUG: Iron Sucrose Injection|DRUG: Venofer Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tailored Therapy for Hodgkin Lymphoma Using Early Interim Therapy PET for Therapy Decision.
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: OTHER: PET/CT post 2 cycles of chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remimazolam and Propofol on the Left Ventricular Strain During Anesthesia Induction for Non-cardiac Surgery
Status: RECRUITING
Conditions: Surgical Procedure, Unspecified
Interventions: DRUG: Remimazolam infusion|DRUG: Propofol infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of the Combination of BAT8008 With BAT1308 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: BAT8008 injection|DRUG: BAT1308 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Buccal Tablets for Exercise Induced Breakthrough Dyspnea
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Fentanyl Buccal Tablet|OTHER: Placebo Buccal Tablet|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Time Gain in the Diagnosis Myocardial Infarction by Troponin Point of Care Testing in the Emergency Room
Status: COMPLETED
Conditions: Non STEMI|Angina Pectoris|Angina, Stable|Angina, Unstable|Angina, Prinzmetal's
Interventions: DEVICE: Laboratory based troponin test|DEVICE: Point of care based troponin test 1|DEVICE: Point of care based troponin test 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Sinus-Venous Stent for the Treatment of Iliofemoral Venous Occlusive Disease
Status: WITHDRAWN
Conditions: Venous Vascular Diseases and Syndromes
Interventions: DEVICE: Sinus-Venous stent (Optimed GmbH)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Favipiravir Plus Hydroxychloroquine and Lopinavir/Ritonavir Plus Hydroxychloroquine in COVID-19
Status: COMPLETED
Conditions: COVID-19|Favipiravir|Kaletra|Hydroxychloroquine|Lopinavir/Ritonavir
Interventions: DRUG: Favipiravir|DRUG: Hydroxychloroquine|DRUG: Lopinavir / Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1a/1b Study of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: CB4211 Dose 1|DRUG: CB4211 Dose 2|DRUG: CB4211 Dose 3|DRUG: CB4211 Dose 4|DRUG: CB4211 Dose 5|DRUG: CB4211 Dose 6|DRUG: CB4211 Dose TBD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: a Study to Evaluate the Pharmacokinetics and Safety of TPN171H Tablets in Patients With Renal Insufficiency and Healthy Subjects
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Erectile Dysfunction
Interventions: DRUG: TPN171H single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Profiling Program of Advanced/Metastatic Pancreatic Cancer Patients
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer|Advanced Pancreatic Cancer
Interventions: BIOLOGICAL: Tumor samples (archival FFPE) and blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Sudapyridine (WX-081) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Sudapyridine 30mg|DRUG: Sudapyridine 100mg SAD|DRUG: Sudapyridine 200mg SAD|DRUG: Sudapyridine 200mg MAD|DRUG: Sudapyridine 300mg MAD|OTHER: Placebo tablet SAD|OTHER: Placebo 200mg SAD|OTHER: Placebo tablet MAD|OTHER: Placebo tablet MAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine for Post-operative Pain Control in Adolescent Bariatric Patients
Status: RECRUITING
Conditions: Bariatric Surgery Candidate|Post-operative Pain
Interventions: DRUG: Treatment with liposomal bupivacaine|DRUG: Treatment with standard bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Immunogenicity of a Universal Influenza A Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: FP-01.1|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Natamycin and Lactulose Vaginal Suppositories in Treatment of Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Vulvovaginal Candidiasis, Genital
Interventions: COMBINATION_PRODUCT: Natamycin + Lactulose 100 mg + 300 mg vaginal suppositories|DRUG: Lactulose 300 mg vaginal suppositories|DRUG: Pimafucin® (natamycin) 100 mg vaginal suppositories
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Improves Postoperative Symptoms After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting|Postoperative Pain|Postoperative Fatigue
Interventions: DRUG: Dexamethasone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study
Status: COMPLETED
Conditions: Coronary Artery Bypass Grafting
Interventions: DIETARY_SUPPLEMENT: Curcuminoids|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2940680 in Pediatric Medulloblastoma or Rhabdomyosarcoma
Status: WITHDRAWN
Conditions: Medulloblastoma, Childhood|Rhabdomyosarcoma
Interventions: DRUG: LY2940680|DRUG: LY2940680
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ginger on Functional Dyspepsia Symptoms and Body Fat Content Among Patients With Functional Dyspepsia
Status: ENROLLING_BY_INVITATION
Conditions: Functional Dyspepsia
Interventions: DIETARY_SUPPLEMENT: Swanson ginger capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease
Status: WITHDRAWN
Conditions: Peripheral Arterial Disease|Angina
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biochemical Changes in Patients With Trochanteric Region Fracture Fixation With DHS Versus PFN
Status: COMPLETED
Conditions: Hip Fractures
Interventions: PROCEDURE: Dynamic Hip Screw|PROCEDURE: Proximal Femoral Nail
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)
Status: NOT_YET_RECRUITING
Conditions: Chronic Hepatitis B Virus Infection
Interventions: DRUG: Daplusiran/Tomligisiran Dose Level 1|DRUG: Daplusiran/Tomligisiran Dose Level 2|DRUG: Bepirovirsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 2-Year, Open-Label, Safety Extension Study of Gevokizumab in Subjects With Pyoderma Gangrenosum
Status: TERMINATED
Conditions: Pyoderma Gangrenosum
Interventions: DRUG: gevokizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease
Status: COMPLETED
Conditions: Gingivitis
Interventions: OTHER: Listerine Advance Gum Defense|OTHER: Mouth rinse containing Chlorhexidine|OTHER: Mouth rinse containing 5% Hydroalcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Impact of Acetaminophen on Performance of Guardian™ Sensor (3) in Adults
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DEVICE: Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. C sensor algorithm applied retrospectively to raw sensor data.|DEVICE: Guardian™ Sensor (3) connected to a Guardian™ Connect Transmitter. Zeus sensor algorithm applied retrospectively to raw sensor data.|DRUG: Acetominophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Liraglutide on Subclinical Atherosclerosis in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Myofascial Decompression and Positional Release Therapies in Chronic Non-specific Neck Pain
Status: COMPLETED
Conditions: Chronic Non-specific Neck Pain
Interventions: OTHER: Myofascial Decompression Therapy|OTHER: positional Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)
Status: COMPLETED
Conditions: Hematologic Malignancies|Nonmalignant Diseases|Immunodeficiencies|Hemoglobinopathies|Genetic Inborn Errors of Metabolism|Fanconi's Anemia|Thalassemia|Sickle Cell Disease
Interventions: DRUG: Clofarabine|DRUG: Fludarabine Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Linagliptin in Combination With Metformin in Treatment Naive Patients With Type 2 Diabetes Mellitus and Insufficient Glycaemic Control
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: metformin placebo|DRUG: linagliptin placebo|DRUG: metformin|DRUG: metformin|DRUG: linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acceptability Study of a New Paediatric Form of Vigabatrin in Infants and Children With Infantile Spasms or Pharmacoresistant Partial Epilepsy
Status: COMPLETED
Conditions: Infantile Spasms
Interventions: DRUG: Vigabatrin: Vigabatrin new ST formulation then Sabril®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Tolerability of Antiretroviral Drug Regimens Used as Pre-Exposure Prophylaxis to Prevent HIV Infection in At-Risk Men Who Have Sex With Men and in At-Risk Women
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Maraviroc|DRUG: Emtricitabine|DRUG: Tenofovir disoproxil fumarate|OTHER: Maraviroc placebo|OTHER: Emtricitabine placebo|OTHER: Tenofovir disoproxil fumarate placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Immunological and Virological Response of Patients With COVID-19 and Presenting an Asymptomatic or Pauci-symptomatic Form (AMBUCOV)
Status: COMPLETED
Conditions: Covid19|SARS-CoV-2
Interventions: DIAGNOSTIC_TEST: Blood count|DIAGNOSTIC_TEST: Blood collection|DIAGNOSTIC_TEST: Nasopharyngeal swab|DIAGNOSTIC_TEST: Saliva samples|DIAGNOSTIC_TEST: Faeces samples|GENETIC: Genetic blood collection|OTHER: Data collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Endorotor Resection In Refractory Barrett's Dysplasia Patients
Status: RECRUITING
Conditions: Barrett's Esophagus With Dysplasia
Interventions: DEVICE: EndoRotor Mucosal Resection System|DEVICE: Continued Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Center, Clinical Study to Evaluate the Safety of a Fragranced Personal Lubricant in Healthy Female Subjects
Status: COMPLETED
Conditions: Erythema|Edema
Interventions: DEVICE: Miami w/ frag Personal lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: RAE Versus MIE in Patients With Esophageal Cancer After Neoadjuvant Therapy
Status: NOT_YET_RECRUITING
Conditions: Surgical Procedure, Unspecified
Interventions: PROCEDURE: ROBOTIC-ASSISTED ESOPHAGECTOMY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TARGTEPO Treatment for Anemia in PD US Trial
Status: TERMINATED
Conditions: Anemia of End Stage Renal Disease
Interventions: BIOLOGICAL: MDGN201 TARGTEPO|BIOLOGICAL: MDGN201 TARGTEPO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal ERT to Prevent Retinal Disease Progression in Children With CLN2
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuronal Ceroid Lipofuscinosis Type 2
Interventions: DRUG: Cerliponase Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effect of Clomiphene Citrate Plus Estradiol Valerate Versus Letrozole on Endometrial Thickness and Pregnancy Rate in Infertile Women
Status: COMPLETED
Conditions: Endometrial Thickness|Pregnancy Rate
Interventions: DRUG: Clomid; Aventis pharma S.AE, Global Napi pharmaceuticals, Cairo, Egypt|DRUG: letrozole (Femara; Novartis pharma AG, Basle, Switzerland)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: YF476 and Type I Gastric Carcinoids (Norway)
Status: TERMINATED
Conditions: Chronic Atrophic Gastritis|Hypergastrinemia|Type I Gastric Carcinoids
Interventions: DRUG: YF476
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Depot Buprenorphine in Treatment Seeking Subjects With Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid Use Disorder|Opioid-related Disorders
Interventions: DRUG: SUBOXONE sublingual film|DRUG: RBP-6000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Aortic Valve Lipoprotein(a) Lowering Trial
Status: WITHDRAWN
Conditions: Aortic Stenosis and Lipoprotein(a) Levels
Interventions: DRUG: Extended release Niacin|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Decision Impact Trial of KidneyIntelX
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Kidney Disease|Chronic Kidney Disease Stage 1|Chronic Kidney Disease Stage 2|Chronic Kidney Disease, Stage 3 (Moderate)
Interventions: DIAGNOSTIC_TEST: KidneyIntelX
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The PUMA Trial is a Trial of a Single ProHema Modulated-Cord Blood (CB) Unit as Part of a Double CB Transplant in Patients With Hematologic Malignancies.
Status: TERMINATED
Conditions: Hematologic Malignancies
Interventions: BIOLOGICAL: ProHema-CB|BIOLOGICAL: Untreated CB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder
Status: UNKNOWN
Conditions: Narcolepsy|Cataplexy
Interventions: OTHER: fMRI|OTHER: Videopolysomnography|OTHER: NC (narcolepsy-cataplexy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Rhinopharyngeal Retrograde Clearance in Children With Acute Viral Bronchiolitis
Status: COMPLETED
Conditions: Acute Viral Bronchiolitis
Interventions: PROCEDURE: Rhinopharyngeal clearance|PROCEDURE: Aspiration|OTHER: 0.9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Moksi® 400mg Tablet and Avelox® 400mg Tablet (Moxifloxacin) Under Fasting Condition in Healthy Adult Pakistani Subjects
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Moksi® 400mg Tablet|DRUG: Drug: Avelox® 400Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: the Effect of Prolonged Inflation Time During Stents Deployment for ST-elevation Myocardial Infarction
Status: UNKNOWN
Conditions: Acute ST-elevation Myocardial Infarction
Interventions: DEVICE: deploying the Drug-eluting Stents with a prolonged time|DEVICE: deploying the Drug-eluting Stents with a conventional time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovation in Postpartum Care for Women With Hypertensive Disorders of Pregnancy
Status: COMPLETED
Conditions: Hypertension in Pregnancy|Hypertension, Pregnancy-Induced|Postpartum Preeclampsia|Blood Pressure Disorders
Interventions: OTHER: At-home Blood Pressure Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sequential High-dose Dexamethasone and Response Adopted PAD or VAD Induction Chemotherapy Followed by High-dose Chemotherapy With Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: high dose dexamethsone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Type 1 Teamwork: A Tool for Parents of Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Type1diabetes|Type1 Diabetes Mellitus
Interventions: BEHAVIORAL: Type 1 Teamwork Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of Fulvestrant Combined With Chidamide in the Treatment of Hormone Receptor-positive Advanced Breast Cancer Resistant to CDK4/6 Inhibitors
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Chidamide+ Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Pharmacokinetics of Certolizumab Pegol in Adults With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Certolizumab pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Immunohistochemical Expression of Heparanase in Helicobacter Pylori-Associated Chronic Gastritis
Status: COMPLETED
Conditions: Chronic Gastritis
Interventions: GENETIC: immunohistochemical detection of Heparanase in chronic gastritis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Adding Dexmedetomidine as Adjuvant to Bupivacaine in US Guided ESPB for Post MRM Pain Management
Status: RECRUITING
Conditions: Erector Spinae Plane Block
Interventions: DRUG: Use Bupivacaine 0.25% Injectable Solution|DRUG: Bupivacaine 0.25% Injectable Solution plus Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I-II Clinical Trial With Autologous Bone Marrow Derived Mesenchymal Stem Cells for the Therapy of Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS)
Interventions: BIOLOGICAL: Bone marrow autologous mesenchymal stem cells transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Arteriovenous Malformations (PAVMs) in Hereditary Haemorrhagic Telangiectasia (HHT)
Status: COMPLETED
Conditions: Hereditary Haemorrhagic Telangiectasia|Pulmonary Arteriovenous Malformation|Cerebral Disorder
Interventions: OTHER: Data collection from standard follow up
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HRYZ-T102 TCR-T Cell for AFP Positive Advanced HCC and Other Solid Tumors
Status: RECRUITING
Conditions: Hepatic Cell Carcinoma
Interventions: BIOLOGICAL: AFP Specific T Cell Receptor T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hepatic Intraarterial Versus Systemic Intravenous 68Ga-PSMA PET/CT for Detection of Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: Gallium Ga 68 Gozetotide|PROCEDURE: Hepatic Artery Embolization|PROCEDURE: Positron Emission Tomography and Computed Tomography Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of the Effectiveness of Myofascial Release Technique in Young Basketball Players
Status: COMPLETED
Conditions: Sports Physical Therapy|Myofascial Release Technique|Performance Enhancement|Basketball Players
Interventions: OTHER: Myofascial Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Vaginal Dinoprostone Prior to Diagnostic Office Hysteroscopy in Postmenopausal Patients
Status: COMPLETED
Conditions: Office Hysteroscopy
Interventions: DRUG: Dinoprostone 3Mg Vaginal Tablet|DRUG: placebo vaginal tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endometrial Scratching by Pipelle on Pregnancy Rate in Unexplained Infertility
Status: UNKNOWN
Conditions: Unexplained Infertility
Interventions: PROCEDURE: Endometrial scratching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT