pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pharmacokinetics Study of MCI-186 in Subjects With Mild or Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy
Interventions: DRUG: MCI-186
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: RAD 1801: Pilot Study of Intra-Urethral Radiotransponder Beacon Guided Focal Prostate Stereotactic Body Radiotherapy
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DEVICE: 16 French Foley Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comprehensive Risk Assessment and Prevention Plan of Osteoporosis and Sarcopenia for the Elderly Participating in Community-based Long-term Care Services
Status: RECRUITING
Conditions: Osteoporosis|Sarcopenia|Frailty
Interventions: BEHAVIORAL: Osteoporosis screening and treatment as needed|BEHAVIORAL: Sarcopenia|BEHAVIORAL: Exercise|DIETARY_SUPPLEMENT: Nutrition|BEHAVIORAL: Pharmaceutical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Research Study Looking Into Levels of the Medicine NNC0385-0434 in the Body and How Well it is Tolerated in Participants With Impaired Kidney Function Compared to Participants With Normal Kidney Function
Status: TERMINATED
Conditions: Chronic Kidney Disease
Interventions: DRUG: NNC0385-0434 A 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Move For Surgery - A Novel Preconditioning Program
Status: COMPLETED
Conditions: Lung Cancer, Nonsmall Cell
Interventions: DEVICE: Move For Surgery Preconditioning Program using a Wearable Activity Tracker (Fitbit) Intervention Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient
Status: UNKNOWN
Conditions: Serum Cystatin C Before and After Coronary Angiogram|Serum Creatinine Before and After Coronary Angiogram
Interventions: PROCEDURE: limb ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma With Doxorubicin, Ifosfamide, Etoposide, and Cisplatin With Early Metabolic Assessment of Response
Status: TERMINATED
Conditions: Osteosarcoma|Lung Metastases
Interventions: DRUG: Dexrazoxane|DRUG: Doxorubicin|DRUG: Cisplatin|DRUG: G-CSF|DRUG: PEG-filgrastim|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Mesna|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-dispersing Liquids as Aerosol Drug Carriers
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: calfactant|DRUG: isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intracranial Pressure After Decompressive Craniectomy
Status: COMPLETED
Conditions: Traumatic Brain Injury|Middle Cerebral Artery Stroke|Intracranial Hemorrhages|Intracranial Hypertension
Interventions: DIAGNOSTIC_TEST: Intracranial pressure monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Estradiol and Progesterone on Arginine Vasopressin Regulation and Serum Sodium Concentration
Status: COMPLETED
Conditions: Exercise Induced Hyponatremia
Interventions: DIETARY_SUPPLEMENT: Gatorade Endurance Formula|OTHER: ganirelix acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Infant Colic Treatment With Probiotics
Status: COMPLETED
Conditions: Infant Colic
Interventions: DIETARY_SUPPLEMENT: B. breve|DIETARY_SUPPLEMENT: B. breve plus L. fermentum|DRUG: Simethicone 20 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
Status: ENROLLING_BY_INVITATION
Conditions: Pulmonary Disease, Chronic Obstructive|Osteoporosis
Interventions: DIAGNOSTIC_TEST: Vital signs|DIAGNOSTIC_TEST: Urine Pregnancy Test|OTHER: Questionnaires|DIAGNOSTIC_TEST: Blood Test|DIAGNOSTIC_TEST: Duel-energy X-ray absorptiometry scan|DIAGNOSTIC_TEST: Multi-detector computed tomography|DIAGNOSTIC_TEST: Dual-energy X-ray absorptiometry scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Convalescent Plasma Trial in COVID -19 Patients
Status: COMPLETED
Conditions: SARS-CoV 2|COVID-19
Interventions: OTHER: plasma therapy using convalescent plasma with antibody against SARS-CoV-2|OTHER: Routine care for COVID-19 patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Analgesia in Shoulder Arthroplasty
Status: WITHDRAWN
Conditions: Shoulder Pain|Opioid Use
Interventions: DRUG: Acetaminophen|DRUG: Celecoxib 200mg|DRUG: Celecoxib 400 mg|DRUG: Ropivacaine|DRUG: Ketorolac|DRUG: Acetaminophen Injectable Product|DRUG: Oxycodone|DRUG: Tramadol|DRUG: Morphine Injectable Solution|DRUG: hydrocodone bitartrate and acetaminophen|DRUG: Morphine|DRUG: Oxycodone Hydrochloride|DRUG: Meloxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irbesartan-Hydrochlorothiazide Phase IV Study: Treatment of Hypertension in Chinese Population
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan 150mg / Hydrochlorothiazide 12.5mg|DRUG: Irbesartan 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Dicopeg Junior in Comparison With Lactulose for the Treatment of Functional Constipation in Children Aged 6 Months to 6 Years.
Status: UNKNOWN
Conditions: Constipation
Interventions: DRUG: polyethylene glycols (PEG) 3350|DRUG: Lactulose Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IVC Ultrasonography Versus Plethysmographic Variability Index for Prediction of General Anesthesia Induction Hypotension
Status: UNKNOWN
Conditions: Hypotension on Induction
Interventions: DEVICE: IVC Ultrasonography|DEVICE: Plethysmographic variability index (PVI) and perfusion index readings (PI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety PK/PD Study of SLV337 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Placebo|DRUG: SLV337|DRUG: SLV337|DRUG: SLV337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Accuracy of [99mTc] ThromboView in the Detection of Deep Vein Thrombosis
Status: COMPLETED
Conditions: Deep Vein Thrombosis
Interventions: DRUG: ThromboView
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or HPV-Positive Oropharyngeal Cancer
Status: WITHDRAWN
Conditions: Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma|Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: IRX-2|BIOLOGICAL: Nivolumab|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Low Intensity Shockwave Therapy in Treating Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcers
Interventions: DEVICE: Extracorporeal Shockwave Therapy and debridement|OTHER: debridement and cleaning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasally and sc Administered Teriparatide in Healthy Volunteers
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: DRUG: Forsteo|DRUG: CP046 PTH CriticalSorb
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
Status: RECRUITING
Conditions: Obesity|Genetic Obesity
Interventions: DRUG: Setmelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Acute Toxicity and Cost Between Whole Breast Irradiation With Sequential Boost and Simultaneous Integrated Boost After Breast Conserving Surgery.
Status: COMPLETED
Conditions: Radiotherapy After Breast Conserving Surgery
Interventions: RADIATION: sequential boost (15 x 2.67 Gy WBI + 4 x 2.5 Gy boost)|RADIATION: SIB (15 x 2.67 Gy WBI and SIB 15 x 2.67-3.12 Gy)|RADIATION: sequential boost (15 x 2.67 Gy WBI + 6 x 2.48 Gy boost)|RADIATION: SIB (15 x 2.67 Gy WBI and SIB 15 x 2.67-3.33 Gy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis
Status: UNKNOWN
Conditions: Diverticulitis, Colonic|Acute Disease
Interventions: DRUG: ertapenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: ECT
Clinical trial: MicroPulse Transscleral Laser Cyclophotocoagulation With the Zig Zag Mode in Glaucoma.
Status: COMPLETED
Conditions: Refractory Glaucoma
Interventions: DEVICE: micropulse transscleral cyclophotocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2A Trial of FMX-8 Treatment for Anemia in Patients With ESRD on Hemodialysis HD
Status: TERMINATED
Conditions: Anemia of Chronic Disease
Interventions: DRUG: FMX-8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy
Status: COMPLETED
Conditions: Breast Cancer|Heart Failure
Interventions: DRUG: Metoprolol|DRUG: Placebo|DRUG: Candesartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Measurement of Lipogenic Flux by Deuterium Resolved Mass Spectrometry Via Non-invasive Breath Analysis
Status: COMPLETED
Conditions: De Novo Lipogenesis (DNL)
Interventions: OTHER: Assessment of de novo lipogenesis non-invasively in exhaled breath
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Effectiveness of S53P4 Bioactive Glass in Treatment of Long-bone Chronic Osteomyelitis
Status: UNKNOWN
Conditions: Osteomyelitis|Bone Infection|Non-Union Fracture|Bone Infection of Lower Leg|Bone Infection of Pelvis, Hip, or Femur
Interventions: DEVICE: S53P4 bioactive glass (BonAlive)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intrathecal Fentanyl or Sufentanil in 1 mg Bupivacaine Spinal Anesthesia for TURP in Elderly Patients
Status: COMPLETED
Conditions: Adequate Anesthesia With Unimpaired Motor Strength
Interventions: DRUG: Fentanyl|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Trial to Describe the Immunogenicity and Safety of 2 Doses of Bivalent rLP2086 (Trumenba) and a Pentavalent Meningococcal Vaccine in Healthy Subjects >=10 to <26 Years of Age.
Status: COMPLETED
Conditions: Meningococcal Vaccine
Interventions: BIOLOGICAL: MenABCWY|BIOLOGICAL: Saline|BIOLOGICAL: rLP2086|BIOLOGICAL: MenACWY-CRM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Localized Prostate Carcinoma
Interventions: BEHAVIORAL: Exercise Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU)
Status: COMPLETED
Conditions: Invasive Candidiasis
Interventions: DRUG: Caspofungin|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of a Web-based, Peer-supported Exercise Program for Patients With Hip and/or Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Major Depressive Disorder (MDD) With Mixed Features - Flexible Dose
Status: COMPLETED
Conditions: Major Depressive Disorder With Mixed Features
Interventions: DRUG: Lurasidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica
Status: COMPLETED
Conditions: Sciatica
Interventions: DRUG: methylprednisolone|DRUG: Ketoprofen|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Pain Control With Celecoxib (Celebrex) in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Celecoxib (Celebrex)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Endorings-2-assisted Colonoscopy: a New Accessory for Improvement of Adenoma Detection Rate?
Status: UNKNOWN
Conditions: Colonic Adenoma|Colonic Polyp|Colonic Neoplasms|Colonoscopy
Interventions: DEVICE: Endorings-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis
Status: COMPLETED
Conditions: Respiratory Insufficiency|Alkalosis
Interventions: DRUG: Acetazolamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project Arthritis Recovering Quality of Life by Means Education II (PARQVE II)
Status: COMPLETED
Conditions: Knee Osteoarthritis|Osteoarthritis
Interventions: BEHAVIORAL: Study Group Educational courses, DVD, print material of lectures|BEHAVIORAL: Control Group only make evaluations / consultations with all professional teams
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Zolpidem CR® in Sleep and Heart Recovery in Cardiac Intensive Care Unit Patients
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Sleep Deprivation
Interventions: DRUG: Zolpidem CR 12.5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of VIrtual REAlity to Reduce Postoperative Anxiety and Pain After Surgery for Colorectal Cancer
Status: RECRUITING
Conditions: Colon Tumor, Malignant|Rectum Tumor|Pain, Postoperative
Interventions: BEHAVIORAL: Pre-operative use of virtual reality headset|PROCEDURE: Standard surgery|BEHAVIORAL: Post-operative use of virtual reality headset
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Assessing the Efficacy and Safety of Intravitreal Injections of DE-122 in Combination With Lucentis® Compared to Lucentis® Monotherapy in Wet Age-related Macular Degeneration Subjects
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: 2.0 mg DE-122 Injectable Solution + Lucentis|DRUG: 4.0 mg DE-122 Injectable Solution + Lucentis|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)
Status: RECRUITING
Conditions: HER2-positive Advanced Gastric Cancer|HER2-positive Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Trastuzumab deruxtecan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Periconceptional Iron Supplementation in Rural Bangladesh
Status: COMPLETED
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Ferrous fumarate (iron)|DIETARY_SUPPLEMENT: folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D Supplements for HIV-positive Patients on cART
Status: COMPLETED
Conditions: HIV-associated Co-morbidities
Interventions: DIETARY_SUPPLEMENT: conventional vitamin D treatment|DRUG: tiered/titrated vitamin D dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Pharmacotherapy on Brain Mechanisms Underlying Cocaine Dependence.
Status: SUSPENDED
Conditions: Opioid-Related Disorders|Cocaine-Related Disorders
Interventions: DRUG: Provigil (Modafinil)|DRUG: Topamax (Topiramate)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Redox State in the Course of Chronic Renal Insufficiency and Hemodialysis: Implications in Morbimortality
Status: COMPLETED
Conditions: Chronic Renal Insufficiency
Interventions: OTHER: Sampling of blood|OTHER: Sampling of blood|OTHER: Sampling of blood
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Chemoprevention of Gastric Cancer by Intervention With Helicobacter Pylori and Cyclooxygenase Pathway
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: Triple therapy for H. pylori infection|DRUG: Cox-2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Phase II, Single-arm Exploratory Clinical Study of Tislelizumab Combined With Anlotinib in the Treatment of Advanced Pulmonary Pleomorphic Carcinoma
Status: RECRUITING
Conditions: Pulmonary Pleomorphic Carcinoma|Immunotherapy|Tislelizumab
Interventions: DRUG: Tislelizumab in combination with anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study is Designed to Assess the Safety and Tolerability of AZD4547 at Increasing Doses in Patients With Advanced Tumours
Status: TERMINATED
Conditions: Cancer|Advanced Solid Malignancies
Interventions: DRUG: AZD4547|DRUG: AZD4547|DRUG: AZD4547
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of Non-Invasive Vagus Nerve Stimulation (nVNS) With gammaCore®, for the Acute Treatment of Migraine Attacks
Status: COMPLETED
Conditions: Migraine
Interventions: DEVICE: gammaCore-S|DEVICE: gammaCore-S Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab With High Dose Methylprednisone Followed by Ofatumumab and Alemtuzumab in 17p CLL
Status: TERMINATED
Conditions: CLL|SLL
Interventions: DRUG: Ofatumumab|DRUG: High-Dose Methylprednisolone|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: epirubicin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cohort Study of Blood Biomarkers for TES
Status: RECRUITING
Conditions: Chronic Traumatic Encephalopathy|Traumatic Encephalopathy, Chronic|Traumatic; Encephalopathy, Postcontusional
Interventions: DIAGNOSTIC_TEST: Blood tests, Cognitive function tests, head MRI (plain scan and DTI sequence) examination and head PET (FDG-PET, Tau-PET and Amyloid-PET) examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Fructose and Allulose Catalytic Effects (FACE) Trial
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Allulose|OTHER: Fructose|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Supplementation With Vitamin D, Calcium or Both on Calcium Absorption and Bone Mineral Content in Children With JRA
Status: COMPLETED
Conditions: Juvenile Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Calcium and cholecalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Advanced Solid Tumors|Non-small Cell Lung Cancer
Interventions: DRUG: Phase I: X-396 (ensartinib)|DRUG: Phase II: X-396 (ensartinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of Cognitive Control Signals in Prefrontal Cortex by Rhythmic Transcranial Magnetic Stimulation
Status: COMPLETED
Conditions: Executive Function
Interventions: DEVICE: Theta TMS|DEVICE: Alpha TMS|DEVICE: Arrhythmic TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Selective Estrogen Receptor Modulators to Enhance the Efficacy of Viral Reactivation With Histone Deacetylase Inhibitors
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tamoxifen|DRUG: Vorinostat|DRUG: Antiretroviral drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valganciclovir in Congenital CMV Infants
Status: COMPLETED
Conditions: Cytomegalovirus Infections
Interventions: DRUG: Valganciclovir|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of RO4905417 in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery
Status: COMPLETED
Conditions: Coronary Heart Disease, Graft Occlusion, Vascular
Interventions: DRUG: Placebo|DRUG: RO4905417
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study on Treatment of Chronic Persistent Bronchial Asthma
Status: RECRUITING
Conditions: Bronchial Asthma
Interventions: DRUG: Ke Chuan Liu Wei Granule|DRUG: Yang He Ping Chuan Granule|OTHER: Ke Chuan Liu Wei Granule placebo|OTHER: Yang He Ping Chuan Granule placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Inhibitor Tislelizumab Maintenance Therapy in Newly Diagnosed DLBCL Patients After ASCT
Status: UNKNOWN
Conditions: Lymphoma, Large B-Cell, Diffuse|Transplantation|Chemotherapy
Interventions: DRUG: PD-1 Inhibitor Tislelizumab maintenance therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (MK-3475-564/KEYNOTE-564)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Caffeine on Deep Inferior Epigastric Perforator (DIEP) Flap Perfusion
Status: WITHDRAWN
Conditions: Breast Reconstruction|Deep Inferior Epigastric Perforator|Microvascular Free Flap Transfer
Interventions: DIETARY_SUPPLEMENT: Caffeinated Coffee|DIETARY_SUPPLEMENT: DecaffeinatedCoffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Ketamine-ketorolac Versus Fentanyl- Ketorolac I.M in Children During Bone Marrow Biopsy
Status: COMPLETED
Conditions: Hematological Malignancy (Leukemia- Lymphoma)
Interventions: DRUG: ketamine-ketorolac|DRUG: fentanyl- ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Bilateral Training Versus Unilateral Training in Stroke
Status: COMPLETED
Conditions: Stroke|Hemiparesis
Interventions: BEHAVIORAL: bilateral upper extremity training|BEHAVIORAL: Unilateral upper extremity training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dimethylfumarate (DMF) in Relapsed/Refractory CLL/SLL
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: dimethyl fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the EGG Abnormalities in Healthy Subjects and in Patients With Idiopathic and Diabetic Gastroparesis.
Status: RECRUITING
Conditions: Gastroparesis|Diabetes Complications|Idiopathic Gastric Motility Disorder|Dyspepsia
Interventions: DEVICE: Electrogastrography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Effectiveness of Night Shift, a Theory-based Customized Video Game
Status: ACTIVE_NOT_RECRUITING
Conditions: Trauma Injury|Physician's Role
Interventions: BEHAVIORAL: Night Shift|BEHAVIORAL: Usual education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: IBI310 (Anti-CTLA-4) in Combination With Sintilimab in Patients With Non-small-cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: NSCLC (Non-small-cell Lung Cancer)
Interventions: DRUG: Sintilimab|DRUG: IBI310
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TEOSYAL® PureSense ULTRA DEEP Versus Restylane® Lidocaine for the Correction of Moderate to Severe Nasolabial Folds in Chinese Adults
Status: RECRUITING
Conditions: Nasolabial Folds
Interventions: DEVICE: injection in NLF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exergame-Based Exercise on Hamstring and Quadriceps Isokinetic Muscle Parameters
Status: RECRUITING
Conditions: Exergaming|Sedentary Behavior|Muscle Strength
Interventions: OTHER: Exergame|OTHER: Game-free Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Response Study of GSK2330672 for the Treatment of Pruritus in Participants With Primary Biliary Cholangitis
Status: COMPLETED
Conditions: Cholestasis
Interventions: DRUG: Placebo|DRUG: GSK2330672
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pexy Versus Non-pexy for Full Thickness Rectal Prolapse
Status: COMPLETED
Conditions: Rectal Prolapse
Interventions: PROCEDURE: sacral rectopexy with sutures or meshes|PROCEDURE: full rectal mobilization from the sacrum without sacral rectopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Comparable Efficacy and Safety of Pulmozyme (Dornase Alfa) Delivered by the eRapid Nebulizer System in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: dornase alfa [Pulmozyme®]|DRUG: dornase alfa [Pulmozyme®]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Between DWP14012 and Three Different Kinds of NSAIDs
Status: UNKNOWN
Conditions: Healthy Male Volunteers
Interventions: DRUG: DWP14012|DRUG: Celecoxib|DRUG: Naproxen|DRUG: Meloxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Teenage Health and Wellness Study
Status: COMPLETED
Conditions: Stress|Externalizing Symptoms|Depression Symptoms|Anxiety
Interventions: BEHAVIORAL: The Mind in Action|BEHAVIORAL: Healthy Topics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Comparison of Mcgrath Mac, C-MAC, and Macintosh Laryngoscope in Novice Users: a Manikin Study
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Mcgrath Mac videolaryngoscope|OTHER: C-MAC videolaryngoscope|OTHER: macintosh laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TELAXMAN - Laser Lithotripsy With Automatic Real-time Stone Recognition
Status: COMPLETED
Conditions: Lithotripsy, Laser
Interventions: DEVICE: Laser lithotripsy with stone recognition|OTHER: Laser lithortripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensity of Physical Activity Level During Daily Living: Unravelling Its Relationship With Chronic Musculoskeletal Disorders and Evaluating Underlying Facilitators and Barriers, An Exploratory Survey Study
Status: UNKNOWN
Conditions: Chronic Musculoskeletal Disease|Exercise Intensity|Physical Activity|Online Survey
Interventions: OTHER: online survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Chemotherapy in Treating Patients With Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy
Status: NOT_YET_RECRUITING
Conditions: Islet Transplantation
Interventions: BIOLOGICAL: Infusion of recipient T regulatory cell|BIOLOGICAL: Infusion of concomitant Donor Derived Vertebral Bone Marrow
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium for Pre-Eclampsia Prevention (CPEP)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Eclampsia|Heart Diseases|HELLP Syndrome|Hypertension|Pre-Eclampsia|Pregnancy Toxemias|Vascular Diseases
Interventions: DRUG: calcium|BEHAVIORAL: dietary supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Brown Adipose Tissue and Body Mass Index
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes Mellitus
Interventions: OTHER: 18F- fluorodeoxyglucose-positron emission tomography Computed Tomography scan and 123I-metaiodobenzylguanidine-single-photon emission computed tomography scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Vaginal Cellulitis or Vaginal Cuff Abscess After Laparoscopic Hysterectomy
Status: UNKNOWN
Conditions: Hysterectomy|Cellulitis|Vaginosis|Abscess|Cuff
Interventions: DRUG: cephalosporin + Metronidazole Vaginal|DRUG: cephalosporin + Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Error-augmented Walking on Gait Performance and Brain Activities in Stroke
Status: UNKNOWN
Conditions: Healthy|Stroke
Interventions: OTHER: Error-augmented treadmill training|OTHER: active control group|OTHER: Error-augmented concept combined physical therapy group|OTHER: conventional physical therapy group|OTHER: NO INTERVENTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lapelga vs Gastrofil
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma|Lymphoma|Engagement, Patient|Febrile Neutropenia
Interventions: DRUG: Grastofil®|DRUG: Lapelga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Binimetinib Plus Belinostat for Subjects With Metastatic Uveal Melanoma
Status: RECRUITING
Conditions: Metastatic Uveal Melanoma
Interventions: DRUG: Binimetinib|DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Hygiene Solutions on Denture Biofilm
Status: COMPLETED
Conditions: Stomatitis
Interventions: OTHER: S1|OTHER: S2|OTHER: S3|OTHER: S4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
Status: COMPLETED
Conditions: Peripheral Artery Disease|Hypertension
Interventions: DRUG: nebivolol|DRUG: Metoprolol succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Study to Determine Safety and Tolerability of ESK-001 in Healthy Participants
Status: COMPLETED
Conditions: Safety and Tolerability
Interventions: DRUG: Experimental drug: ESK-001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Proton Pump Inhibition on Palpitations
Status: COMPLETED
Conditions: Arrhythmia
Interventions: DRUG: Lansoprazole Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Melatonin Treatment
Status: COMPLETED
Conditions: Metabolic Disease|Insulin Sensitivity|Glucose Metabolism Disorders (Including Diabetes Mellitus)|Type 2 Diabetes Mellitus|Blood Pressure|Inflammation
Interventions: DRUG: Melatonin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI
Status: RECRUITING
Conditions: SCI - Spinal Cord Injury|Upper Extremity Dysfunction|Upper Extremity Problem
Interventions: DEVICE: MyoMo|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Therapy for Patients With Covid-19 Using Food Supplements Viusid + Asbrip
Status: COMPLETED
Conditions: Covid19|COVID-19 Pneumonia|COVID-19 Respiratory Infection|Viral Infection|Respiratory Tract Infections|Infection, Coronavirus|SARS-CoV2 Infection
Interventions: DIETARY_SUPPLEMENT: Viusid and Asbrip|DRUG: COVID-19 Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion
Status: COMPLETED
Conditions: Syndrome of Inappropriate ADH (SIADH) Secretion|Hyponatremia
Interventions: DRUG: satavaptan (SR121463B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: administration of riboflavin for epi-off cross-linking|PROCEDURE: administration of riboflavin for epi-on cross-linking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study to Evaluate the Safety and Preliminary Efficacy of IL6-receptor Antibody Sarilumab in Combination With antiPD1 Antibody Cemiplimab for Patients With Non-small Cell Lung Cancer.
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: Cemiplimab|DRUG: Kevzara (Sarilumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Reslizumab Dose Escalation in Patients With Severe Asthma
Status: COMPLETED
Conditions: Asthma; Eosinophilic
Interventions: BIOLOGICAL: Reslizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CDX-1127 (Varlilumab) in Patients With Select Solid Tumor Types or Hematologic Cancers
Status: COMPLETED
Conditions: CD27 Expressing B-cell Malignancies for Example Hodgkin's Lymphoma|Chronic Lymphocytic Leukemia|Mantle Cell Lymphoma|Marginal Zone B Cell Lymphoma)|Any T-cell Malignancy|Solid Tumors (Metastatic Melanoma, Renal (Clear) Cell Carcinoma|Hormone-refractory Prostate Adenocarcinoma, Ovarian Cancer|Colorectal Adenocarcinoma, Non-small Cell Lung Cancer)|Burkett's Lymphoma|Primary Lymphoma of the Central Nervous System
Interventions: DRUG: CDX-1127|DRUG: CDX-1127|DRUG: CDX-1127
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCT Evaluation of Healing of COMBO Stent
Status: COMPLETED
Conditions: Coronary Restenosis|Coronary Thrombosis
Interventions: DEVICE: COMBO Stent (OrbusNeich Medical, Fort Lauderdale, Florida)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Tibial Nerve Stimulation for Idiopathic Overactive Bladder
Status: NOT_YET_RECRUITING
Conditions: Overactive Bladder|Overactive Bladder Syndrome|Overactive Detrusor
Interventions: BEHAVIORAL: Bladder training|DEVICE: Transcutaneous tibial nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TP-38 Toxin in Treating Young Patients With Recurrent or Progressive Supratentorial High-Grade Glioma
Status: TERMINATED
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: TGFa-PE38 immunotoxin|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study
Status: ENROLLING_BY_INVITATION
Conditions: Postural Orthostatic Tachycardia Syndrome|COVID-19|Post COVID-19 Condition|Post-Acute COVID-19 Syndrome
Interventions: OTHER: Individual tailored exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The TRUST Study - CardioVascular Imaging IMT
Status: COMPLETED
Conditions: Thyroid Dysfunction|Atherosclerosis|Heart Failure
Interventions: DRUG: Levothyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Online Breastfeeding Counseling Given At The Post-Birth Period On Breastfeeding Behavior
Status: NOT_YET_RECRUITING
Conditions: Breastfeeding|Breastfeeding Support
Interventions: OTHER: The Effect Of Online Breastfeeding Counseling Given At The Post-Birth Period On Breastfeeding Behavior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparative Evaluation of Various Patient Centered Outcomes Following Gingival Depigmentation Using Diode LASER in Different Modes: A Randomized Clinical Trial
Status: UNKNOWN
Conditions: Pain, Postoperative|Healing Surgical Wounds|Analgesia|Temperature Change, Body
Interventions: PROCEDURE: 400 µm fibre length will be used in continuous contact mode|PROCEDURE: 400 µm fibre length will be used in pulsed contact mode|PROCEDURE: 300 µm fibre length will be used in continuous mode|PROCEDURE: 300 µm fibre length will be used in pulsed contact mode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases
Status: COMPLETED
Conditions: Chronic Idiopathic Urticaria|Chronic Idiopathic Pruritus|Lichen Planus|Lichen Simplex Chronicus|Plaque Psoriasis
Interventions: DRUG: KPL-716|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ameliorating Stroke-induced Hemianopia Via Multisensory Training
Status: NOT_YET_RECRUITING
Conditions: Hemianopia, Homonymous|Cortical Blindness, Unspecified Side of Brain
Interventions: BEHAVIORAL: Multisensory Training|BEHAVIORAL: Unisensory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability of Intranasal Epinephrine
Status: COMPLETED
Conditions: Anaphylaxis|Anaphylactic Reaction
Interventions: DRUG: A: Epinephrine injection|DRUG: B: FMXIN002 3.6mg|DRUG: C: FMXIN002 4.0mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Efficacy of Dupilumab in Patients ≥6 Months to <6 Years With Moderate-to-Severe Atopic Dermatitis (Liberty AD PRESCHOOL)
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Dupilumab|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Stratification of VT / VF After Myocardial Infarction Based on Cardiac MRI 2
Status: RECRUITING
Conditions: Myocardial Infarction|Ventricular Tachycardia|Ventricular Fibrillation
Interventions: DEVICE: MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p