pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Effect of Mindfulness-based Yoga and Meditation on Some Parameters in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Mindfulness-based Meditation and Yoga program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Coronary Artery Computed Tomography to Diagnose Emergency Chest Pain
Status: COMPLETED
Conditions: Chest Pain|Angina Pectoris|Myocardial Infarction
Interventions: PROCEDURE: coronary artery computed tomography angiogram|PROCEDURE: single photon emission computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HELIOS China Registry: Evaluation of the HELIOS Stent in a 'Real-World' Patient Population
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: HELIOS biodegradable polymer sirolimus-eluting stents
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of A Single Dose of Lorazepam on Salivary Cortisol Response in Children Undergoing Digestive Endoscopy:
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: Lorazepam|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin Calcium in Preventing Metabolic Syndrome in Prostate Cancer Patients Receiving Androgen-Deprivation Therapy
Status: WITHDRAWN
Conditions: Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: atorvastatin calcium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prophylactic HIPEC for Colorectal Cancers at High Risk of Developing Peritoneal Metastases
Status: UNKNOWN
Conditions: Colorectal Cancer|Peritoneal Metastases
Interventions: PROCEDURE: HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Growth Hormone Administration and Its Effects on Cardiovascular Risk Factors in Growth Hormone Deficient Women
Status: COMPLETED
Conditions: Growth Hormone Deficiency
Interventions: DRUG: Somatropin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Menstrual Cycle Phase and Protein Dose on Muscle Protein Synthesis
Status: COMPLETED
Conditions: Muscle Protein Synthesis
Interventions: DIETARY_SUPPLEMENT: Dose of protein|OTHER: Menstrual cycle phase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Taste Profile of Different JNJ-53718678 Oral Liquid Formulations in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Formulation A|DRUG: Formulation B|DRUG: Formulation C|DRUG: Formulation D|DRUG: Formulation E|DRUG: Formulation F|DRUG: Formulation M1|DRUG: Formulation M2|DRUG: Formulation M3|DRUG: Formulation N1|DRUG: Formulation N2|DRUG: Formulation N3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Immune Checkpoint Inhibition With Radiation Therapy in Unresectable, Non-metastatic Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: DRUG: MEDI4736|DRUG: Tremelimumab|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Validation and Comparison of Different Ultrasound Methods for Discrimination Between Benign and Malignant Ovarian/Tubal Masses Prior to Surgery
Status: UNKNOWN
Conditions: Patients With Adnexal Mass Prior to Surgery
Interventions: OTHER: Standardized transvaginal ultrasound examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MGD007 Combined With MGA012 in Relapsed/Refractory Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: BIOLOGICAL: MGD007 + MGA012
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficiency of γδ T Cell Against Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: PROCEDURE: Cryosurgery or IRE surgery|BIOLOGICAL: γδ T cell|OTHER: γδ T cells/ A Cryosurgery or IRE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Mesenchymal Stem Cells for the Repair of Large Area Burn Wounds
Status: NOT_YET_RECRUITING
Conditions: Large Area Burns
Interventions: PROCEDURE: Stem cell preparation combined with Reticular skin|PROCEDURE: Stem cell preparation combined with MEEK skin|PROCEDURE: Stem cell preparation combined with split-thickness skin|PROCEDURE: autologous skin grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confocal Laser Endomicroscopy, IBS and Stress
Status: WITHDRAWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Stress|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Bioavailability Study of FL-101 in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: FL-101-Intravenous|DRUG: FL-101-Subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Broxuridine Plus Surgery in Treating Patients With Stage I or Stage II Prostate Cancer
Status: COMPLETED
Conditions: Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer
Interventions: DRUG: bromodeoxyuridine|PROCEDURE: conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Efficacy of 180 mg Subcutaneous Risperidone From 6 mg Oral Risperidone
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PERSERIS|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens
Status: TERMINATED
Conditions: Open Fracture|Post-Op Wound Infection
Interventions: DRUG: Ceftriaxone|DRUG: Ampicillin/sulbactam|DRUG: Piperacillin/tazobactam|DRUG: Cefazolin + Gentamicin|DRUG: Clindamycin + Gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prospective Exploratory Study of FAPi PET/CT in Prostate Cancer With Histopathology Validation
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Malignant Neoplasm in the Prostate Gland|Prostate Carcinoma|Recurrent Prostate Carcinoma
Interventions: PROCEDURE: Computed Tomography|OTHER: Gallium Ga 68 FAPi-46|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: STIMULUS MDS-US : Sabatolimab Added to HMA in Higher Risk MDS
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: MBG453|DRUG: Azacitidine|DRUG: Decitabine|DRUG: INQOVI (oral decitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Evaluate Contraceptive Efficacy and Safety of the Transdermal Contraceptive System of Norelgestromine and Ethinyl Estradiol
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Norelgestromine (NLGM)/ethinyl estradiol (EE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Two-part Study to Assess the Safety and Preliminary Efficacy of Givinostat in Patients With Polycythemia Vera
Status: COMPLETED
Conditions: Polycythemia Vera
Interventions: DRUG: Givinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Transection of the Omohyoid in the Incidence of Dysphagia in Patients
Status: NOT_YET_RECRUITING
Conditions: Anterior Cervical Pain
Interventions: PROCEDURE: Discectomy of Omohyoid|PROCEDURE: Control group no discectomy of Omohyoid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis|Inflammatory Bowel Disease
Interventions: DRUG: Vedolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Assessing the Impact on Facial Skin Quality, Hydration, and Skin Barrier of Three (3) Hydrafacial Treatments in Adults of All Skin Types.
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutis Laxa Facialis|Xeroderma
Interventions: DEVICE: HydraFacial Syndeo System|DRUG: ReGen-GF|DEVICE: HydraFacial Elite MD System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis
Status: COMPLETED
Conditions: Prurigo Nodularis|Nodularis Prurigo|Prurigo
Interventions: DRUG: nalbuphine HCl ER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-utility Analysis of Fenestrated Aortic Stents Versus Open Surgery for the Treatment of Complex Abdominal Aortic Aneurysms
Status: COMPLETED
Conditions: Complex Abdominal Aortic Aneurysm, ie. Juxtarenal or Suprarenal Aortic Aneurysms, Treated by Fenestrated Endovascular Aortic Aneurysm Repair or Open Repair
Interventions: PROCEDURE: Fenestrated endovascular aortic aneurysm repair|PROCEDURE: open repair of abdominal aortic aneurysm.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prenatal Yoga to Prevent Postpartum Depression
Status: NOT_YET_RECRUITING
Conditions: Postpartum Depression
Interventions: BEHAVIORAL: Prenatal Yoga to Prevent Postpartum Depression (PRY-D) intervention|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial
Status: RECRUITING
Conditions: Acute Exacerbation of COPD
Interventions: PROCEDURE: Personalized antibiotic treatment|OTHER: Usual antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage
Status: UNKNOWN
Conditions: Brain Ischemia|Intracranial Hemorrhages
Interventions: DRUG: Cilostazol|DRUG: Probucol|DRUG: Aspirin|DRUG: placebo of cilostazol|DRUG: placebo of aspirin|DEVICE: ankle-brachial index (ABI)|DEVICE: intima-medial thickness (IMT)|DEVICE: new asymptomatic brain hemorrhage|DEVICE: new ischemic lesions on follow-up FLAIR images
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioral Therapy for Core Autism Symptoms in School-Aged Children: A Randomized, Controlled Trial
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: cognitive behavioral therapy|BEHAVIORAL: Usual community care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin in Heart Failure With Reduced Ejection Fraction and End Stage Renal Disease
Status: NOT_YET_RECRUITING
Conditions: Heart Failure With Reduced Ejection Fraction|End Stage Renal Disease on Dialysis
Interventions: DRUG: Empagliflozin 25 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b Clinical Trial to Evaluate PEP and EUFLEXXA for Knee Osteoarthritis (KOA)
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: COMBINATION_PRODUCT: PEP/Euflexxa|DRUG: PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅲ Clinical Study Trial of Felbinac Trometamol Injection in China
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Felbinac Trometamol Injection|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SMART Brain Health in African-Americans
Status: UNKNOWN
Conditions: Opioid Use Disorder|Substance Use Disorders|Dopamine Dysregulation Syndrome|African Americans
Interventions: DIETARY_SUPPLEMENT: KB220Z|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Late Phase II Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: DE-089 ophthalmic solution|DRUG: DE-089 ophthalmic solution|DRUG: Placebo ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Effectiveness of Screening and Brief Interventions for Alcohol and Tobacco During Breast Cancer Treatment (ONKODETOX)
Status: COMPLETED
Conditions: Breast Cancer|Psychology, Social
Interventions: BEHAVIORAL: Motivational Intervention group|BEHAVIORAL: Educational advises group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease
Status: COMPLETED
Conditions: Prurigo Nodularis
Interventions: DRUG: Pimecrolimus|DRUG: Hydrocortisone|DRUG: Pimecrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Residual Neuromuscular Block of Rocuronium in Chemotherapy Patients Under Sevoflurane Anesthesia
Status: UNKNOWN
Conditions: Chemotherapeutic Toxicity
Interventions: DRUG: sevoflurane anesthesia|DRUG: Propofol Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
Status: NOT_YET_RECRUITING
Conditions: Depressive Disorder, Major|Anxiety Disorder
Interventions: DRUG: Nociceptin Receptor Antagonist|DEVICE: Aversive stimuli
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Resolution Enhancement by a Supplemental Obstruction Lessening Venoactive Drug for Eight Weeks in Deep Vein Thrombosis
Status: COMPLETED
Conditions: Deep Vein Thrombosis
Interventions: DRUG: Hydroxyethylrutoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cabozantinib in Advanced Adrenocortical Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: Cabozantinib-s-malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mupirocin to Reduce Staphylococcus Aureus Colonization in Infants Hospitalized in a NICU
Status: COMPLETED
Conditions: Staphylococcus
Interventions: DRUG: Mupirocin Topical Ointment|DRUG: Petroleum Jelly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Head-to-Head Study of Etelcalcetide (AMG 416) and Cinacalcet
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism|Chronic Kidney Disease
Interventions: DRUG: Etelcalcetide|DRUG: Cinacalcet|DRUG: Oral Placebo|DRUG: Intravenous Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ZAP-IT: ZN-c3 + Carboplatin + Pembrolizumab in mTNBC
Status: SUSPENDED
Conditions: Breast Cancer|Breast Cancer Female|Triple Negative Breast Cancer|Hormone Receptor Negative Malignant Tumor Breast Triple|HER2-negative Breast Cancer
Interventions: DRUG: Azenosertib|DRUG: Carboplatin|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Inulin-type Fructose Extracted From Jerusalem Artichoke on Improving Prediabetic State of Type 2 Diabetes
Status: COMPLETED
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: NIUCHANG|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome
Status: NOT_YET_RECRUITING
Conditions: Clinically Isolated Syndrome|Multiple Sclerosis
Interventions: OTHER: Optic nerve MRI sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Illness Management and Recovery- a Cluster Randomized Controlled Trial Within a Forensic Mental Inpatient Setting
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychotic Disorders|Forensic Psychology|Forensic Nursing|Antisocial Personality Disorder|Substance Use Disorders
Interventions: BEHAVIORAL: Illness Management and Recovery treatment programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sildenafil Trial in Children and Young Adults With CF
Status: WITHDRAWN
Conditions: Cystic Fibrosis With Mild to Moderate Lung Disease|CMRI of Lung Perfusion|Lung Perfusion|Lung Vascularization
Interventions: DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Naloxone Methadone Combination (NAMEKO)
Status: WITHDRAWN
Conditions: Opiate Dependence
Interventions: DRUG: Methadone, naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Inotuzumab Ozogamicin in Chinese Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: inotuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incretin-based Therapy in Preclinical Type 1 Diabetes in Adults
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: DRUG: Victoza®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment With Velcade (Bortezomib) Plus Dexamethasone (VD) or VD Plus Cyclophosphamide or VD Plus Lenalidomide in Patients With Multiple Myeloma Stabilized After 4 Cycles of VD
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Cyclophosphamide|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Hsp90 Inhibitor AUY922 Plus Capecitabine for the Treatment of Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Metastatic or Unresectable Solid Tumor Malignancy
Interventions: DRUG: Capecitabine|DRUG: Hsp90 Inhibitor AUY 922
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trandolapril 4 mg Tablet Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Trandolapril 4 mg Tablets|DRUG: Mavik® 4 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Changes in Eye Shape With Myopia Management Interventions
Status: NOT_YET_RECRUITING
Conditions: Myopia
Interventions: DRUG: Atropine Ophthalmic|DEVICE: MiSight 1-day disposable contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Flare Type Self-expandable Metal Stents (SEMS) vs Plastic Stent for the Treatment of Difficult Common Bile Duct Stone
Status: NOT_YET_RECRUITING
Conditions: Biliary Stones|Bile Duct Diseases|Bile Duct Obstruction
Interventions: DEVICE: Biliary drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bezafibrate Plus Berberine in Mixed Dyslipidemia
Status: COMPLETED
Conditions: Mixed Dyslipidemia
Interventions: DRUG: Berberine|DRUG: Bezafibrate|DRUG: Berberine plus Bezafibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Sucrose In The Treatment of Restless Legs Syndrome: Safety of Three Dose Regimens as Evaluated by Clinical Assessments
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Cohort I|DRUG: Cohort II|DRUG: Cohort III
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Early Postpartum Intrauterine Contraception
Status: COMPLETED
Conditions: Unplanned Pregnancy
Interventions: DRUG: Levonorgestrel-Releasing Intrauterine Contraceptive System (LNG-IUS), 52 Mg, 5 Year Duration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of the Kinesio Taping in Fibromyalgia.
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: OTHER: Upper trunk group (UTG)|OTHER: Global trunk group (GTG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modi-1 in Breast, Head and Neck, Ovarian, or Renal Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Cancer|Renal Cell Cancer|High Grade Ovarian Serous Adenocarcinoma|Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: Modi-1/Modi-1v|BIOLOGICAL: Pembrolizumab|DEVICE: MicronJet600™ microneedle device (NanoPass)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Clinical Project to Evaluate the Regenerative Capacity of CardioCell in Patients With No-option Critical Limb Ischemia (N-O CLI)
Status: UNKNOWN
Conditions: Critical Limb Ischemia
Interventions: DRUG: CardioCell|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 4 Week Combination of BI 207127 NA With Peg-IFN and Ribavirin in Chronic HCV Patients
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: BI 207127 middle dose +SOC|DRUG: BI 207127 high dose+SOC|DRUG: Placebo + SOC|DRUG: BI 207127 low dose + SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study Of The Safety And Efficacy Of AG-013,958 In Subjects With Subfoveal Choroidal Neovascularization Associated With Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: AG-013,958
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of F8IL10 (Dekavil) in Patients With Active RA Receiving MTX
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: F8IL10|DRUG: MTX|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Results of Suprachoroidal Steroids Injections in Two Chorioretinal Diseases
Status: UNKNOWN
Conditions: Central Serous Chorioretinopathy|Irvine-Gass Syndrome|Pars Planitis|Cystoid Macular Edema
Interventions: DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Catheter Ablation on Left Atrial Function in Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Cryoballoon ablation|PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healing Abutment Materials on Matrix Metalloproteinase-8 Level in Peri-implant Crevicular Fluid
Status: COMPLETED
Conditions: Dental Implants
Interventions: OTHER: Stock healing abutments|OTHER: Compoiste healing abutments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A ComparIson of Strategies to PrepAre SeveRely CALCified Coronary Lesions
Status: COMPLETED
Conditions: Calcified Coronary Artery Disease (Grade 3)
Interventions: DEVICE: Super High-Pressure NC PTCA Balloon (OPN NC)|DEVICE: Scoring PTCA Balloon (NSE Alpha)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastrozole in Preventing Breast Cancer in Postmenopausal Women at Increased Risk of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Recombinant SARS-CoV-2 Fusion Protein Vaccine Booster Immunization Study to Evaluate the Safety and Immunogencity
Status: UNKNOWN
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: Recombinant SARS-CoV-2 Fusion Protein Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Intracapsular Injection|PROCEDURE: Periarticular Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Yogurts Supplemented With Mobilee on Joint Function in Healthy Individuals With Joint Discomfort
Status: COMPLETED
Conditions: Low Intensity Knee Gonalgia
Interventions: DIETARY_SUPPLEMENT: Yogurt supplemented with Mobilee|DIETARY_SUPPLEMENT: Yogurt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Evaluation of the Efficacy, Safety and Immunogenicity of Adalimumab in Comparison With Humira®
Status: RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: Adalimumab|DRUG: Humira
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: UAB 0718 - Phase II Trial to Assess Target Oral Therapy as Adjuvant Chemoprevention in High-Risk Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Procedural Success and Safety of the Nit-Occlud® Patent Foramen Ovale (PFO) Closure Device and Its Application System
Status: COMPLETED
Conditions: Foramen Ovale, Patent|Heart Catheterization|Heart Septal Defects, Atrial
Interventions: DEVICE: Nit-Occlud® PFO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military
Status: TERMINATED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Sildenafil Citrate 50Mg Tab|DEVICE: functional Near-infrared Spectroscopy (fNIRS)|OTHER: Carbon Dioxide (CO2) 5%|OTHER: Neuropsychological Assessments|DRUG: Gadolinium contrast infusion|PROCEDURE: Blood sample collection for research purposes|OTHER: Structural brain Magnetic Resonance Imaging (MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of FYU-981 in Hyperuricemic Outpatients With or Without Gout (Effect on Two Hyperuricemic Types)
Status: COMPLETED
Conditions: Hyperuricemia With or Without Gout
Interventions: DRUG: FYU-981
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mobile Health to Enhance Exercise in Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Telemedicine|Mobile Applications|Exercise Therapy
Interventions: BEHAVIORAL: Exercise Programme and Counselling|DEVICE: Polar Ignite and App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody With or Without gp100 Peptides Plus Montanide ISA-51 in Treating Patients With Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: gp100 antigen|BIOLOGICAL: incomplete Freund's adjuvant|BIOLOGICAL: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin Plus Capecitabine in the Perioperative Treatment of Locally Advanced Gastric Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: XELOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Time Restricted Eating (TRE)|BEHAVIORAL: Caloric Restriction (CR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Caudal Injection Volume on Optic Nerve Sheath Diameter and Cerebral Oxygenation
Status: COMPLETED
Conditions: Anesthesia, Caudal|Pediatrics|Elevated Intracranial Pressure
Interventions: PROCEDURE: Caudal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study of Dideoxycytidine Plus Zidovudine (AZT) in HIV-Infected Children Who Have Taken AZT
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Lenalidomide, Bortezomib and Dexamethasone Induction Therapy With Either Intravenous or Subcutaneous Isatuximab in Patients With Newly Diagnosed Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Isatuximab|DRUG: Isatuximab|DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrauterine Navigation Using Intrauterine Insemination Catheter for Mock Embryo Transfer Prior to Day 3 Embryo Transfer on Pregnancy Rate: A Pilot Study
Status: COMPLETED
Conditions: The Study Focusses on Improving the Implantation Rate in IVF
Interventions: DEVICE: endometrial navigation one day before the embyo transfer using IUI catheter ,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surveillance Monitoring of Opioid Abuse in Poison and Drug Treatment Centers
Status: UNKNOWN
Conditions: Opioid-related Disorders|Opioid Addiction|Narcotic Abuse|Drug Abuse
Interventions: OTHER: Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS) System of post-marketing surveillance of prescription medication abuse, misuse, and diversion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
Status: RECRUITING
Conditions: Palsy Supranuclear|Supranuclear Palsy, Progressive
Interventions: DEVICE: Repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab, a Monoclonal Antibody Against PD-1, in Combination With Capecitabine and Oxaliplatin (CAPOX) in People With Advanced Biliary Tract Carcinoma (BTC)
Status: COMPLETED
Conditions: Biliary Tract Neoplasms|Cholangiocarcinoma|Bile Duct Cancer|Liver Cancer|Gallbladder Cancer
Interventions: BIOLOGICAL: Pembrolizumab (MK-3475)|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceramic-on-Ceramic Versus Ceramic-on-HXLPE THA
Status: COMPLETED
Conditions: Osteoarthritis, Hip|Avascular Necrosis of the Femoral Head|Arthropathy of Hip|Hip Arthr
Interventions: PROCEDURE: COC THA|PROCEDURE: COP THA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Strategy to Improve Adherence of Roflumilast
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Roflumilast escalation dosage|DRUG: Roflumilast conventional dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Different Concentrations of ZK 245186 in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: ZK 245186|DRUG: Placebo (vehicle ointment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage II Childhood Hodgkin Lymphoma|Stage III Childhood Hodgkin Lymphoma|Stage IV Childhood Hodgkin Lymphoma
Interventions: DRUG: brentuximab vedotin|DRUG: etoposide|DRUG: prednisone|DRUG: doxorubicin|DRUG: cyclophosphamide|DRUG: Dacarbazine(R)|DRUG: filgrastim|OTHER: quality of life assessment|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 22G-Adapt Needle Biopsy Versus Fine-needle Aspiration in Endoscopic Ultrasound-guided Sampling of Solid Lesions
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Neoplasms|Mediastinal Neoplasms|Abdominal Neoplasm, Excluding Pancreas Neoplasm
Interventions: DEVICE: FNA group|DEVICE: Adapt FNB group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study of the Effects on Sleep Disordered Breathing (SDB) When Using the Drug Liraglutide for 4 Weeks
Status: COMPLETED
Conditions: Sleep Apnea|Sleep Disordered Breathing
Interventions: DRUG: liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate CIS43LS in Healthy Adults
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: VRC-MALMAB0100-00-AB|OTHER: Plasmodium falciparum (P. falciparum) sporozoite challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel
Status: RECRUITING
Conditions: PTSD
Interventions: BEHAVIORAL: Exposure Therapy|BEHAVIORAL: Interpersonal Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remyelination in Multiple Sclerosis: a PET-MR Longitudinal Study Investigating Individual Profiles of Myelin Repair and the Contribution of Neuroinflammation
Status: RECRUITING
Conditions: Multiple Sclerosis|Inflammatory Disease
Interventions: PROCEDURE: PET-MRI with [18F]-Florbetaben and PET-MRI with [18F]-DPA-714
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetic/Pharmacodynamic Characteristics and Food Effect of HSG4112 in High Doses
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: HSG4112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab Combined With Pyrrolidine and Chemotherapy for Locally HER2 Positive Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Trastuzumab combined with Pyrotinib and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl)|DRUG: DDS-06C (650 mg acetaminophen and 75 mg tramadol)|DRUG: Zaldiar®|DRUG: Ultracet®|DRUG: Two tablets of DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl), multiple doses, under both fed and fasting conditions|DRUG: Zaldiar®, multiple doses,(fed & fasting):|DRUG: Ultracet®, multiple doses, (fed & fasting)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Biologically Guided Flap Stability: the Role of Periosteum Retention on the Performance of the Coronally Advanced Flap
Status: COMPLETED
Conditions: Gingival Recession, Localized
Interventions: PROCEDURE: CAF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Parental Acceptance to Silver Diamine Fluoride Staining Before and After Masking the Colour With Glass Ionomer
Status: COMPLETED
Conditions: Caries Arrested
Interventions: PROCEDURE: Silver diamine fluoride|PROCEDURE: Silver diamine fluoride and glass ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aspirin and Enoxaparin for VTE in Trauma
Status: TERMINATED
Conditions: Venous Thromboembolism|Thromboprophylaxis|Trauma
Interventions: DRUG: Aspirin|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oxygen Reserve Index and Prevention of Hyperoxemia
Status: COMPLETED
Conditions: Hyperoxemia|Oxygen Reserve Index|Hyperoxia|Fraction of Inspired Oxygen
Interventions: DRUG: Oxygen|DEVICE: Masimo Root Radical 7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adaptive Intervention to Facilitate PrEP Uptake/Adherence Among Transgender Women
Status: COMPLETED
Conditions: Prevention
Interventions: BEHAVIORAL: PrEP N' Shine: Strength Based Case Management (Stage 1)|BEHAVIORAL: PrEP N' Shine: Stepped Adherence Training and Counseling (Stage 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Dose-Response, Efficacy (Immunogenicity) and the Safety of GC1109
Status: COMPLETED
Conditions: Anthrax
Interventions: BIOLOGICAL: GC1109 or Placebo of GC1109
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Addition of Liraglutide to Patients With Type 2 Diabetes Treated With Multiple Daily Insulin Injections
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Versus Later Re-valving in Tetralogy of Fallot With Free Pulmonary Regurgitation
Status: RECRUITING
Conditions: Tetralogy of Fallot|Pulmonary Regurgitation
Interventions: PROCEDURE: Pulmonary valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of 4 Daily Disposable Soft Contact Lenses
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: verofilcon A contact lenses|DEVICE: senofilcon A contact lenses|DEVICE: stenfilcon A contact lenses|DEVICE: etafilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thromboembolism (DVT) and Pulmonary Embolism (PE). A Study of BAY59-7939 in the Prevention of Venous Thrombo Embolism (VTE) in Subjects Undergoing Elective Total Knee Replacement.
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Enoxaparin|DRUG: Placebo: tablet of Rivaroxaban|DRUG: Placebo: syringes of Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Multiple Myeloma and Renal Disease
Status: COMPLETED
Conditions: Relapsed Multiple Myeloma|End-stage Renal Disease
Interventions: DRUG: Carfilzomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Yhteispeli - Effectiveness Study on Promoting Childrens' Socio-emotional Skills in School
Status: COMPLETED
Conditions: Children's Socio-emotional Skills and Psychiatric Symptoms
Interventions: OTHER: Yhteispeli, whole school programme|OTHER: Two theoretical lectures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION