pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1B Clinical Trial of Trametinib Plus Digoxin in Patients With Unresectable or Metastatic BRAF Wild-type Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Trametinib (2mg)/Digoxin (.25mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ShapeMatch Cutting Guide Functional Outcomes Study
Status: TERMINATED
Conditions: Arthroplasty, Replacement, Knee
Interventions: DEVICE: Triathlon® CR/Kinematic Alignment|DEVICE: Triathlon® CR/Neutral Overall Limb Alignment|DEVICE: Triathlon® CR/Conventional Limb Alignment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of a PrEP Decision Aid for Women Seeking Domestic Violence Services in Baltimore
Status: RECRUITING
Conditions: HIV|Violence, Gender-Based|Pre-Exposure Prophylaxis
Interventions: BEHAVIORAL: Individual PrEP Decision Aid|BEHAVIORAL: CDC PrEP Video|BEHAVIORAL: Shared PrEP Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Adverse Events and How Intravenously (IV) Infused ABBV-400 Moves Through the Body of Adult Participants With Unresectable Locally Advanced/Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: ABBV-400
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Antenatal Model to Prevent Preterm Delivery
Status: UNKNOWN
Conditions: Preterm Delivery|Pregnant Women|Antenatal Care Model
Interventions: BEHAVIORAL: antenatal model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study of TQB3616 Capsules Combined With Anlotinib Hydrochloride Capsules or Standard Chemotherapy Second-line and Above in the Treatment of Advanced Lung Cancer
Status: UNKNOWN
Conditions: Advanced Lung Carcinoma
Interventions: DRUG: TQB3616 capsules|DRUG: Anlotinib Hydrochloride capsules|DRUG: Irinotecan Hydrochloride for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: Photodynamic therapy (PDT)|DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Pediatric Vaccines When Administered With Menactra® in Healthy Toddlers
Status: COMPLETED
Conditions: Meningococcal Meningitis|Measles|Mumps|Rubella|Varicella
Interventions: BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Conjugate Vaccine|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Conjugate Vaccine|BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Conjugate Vaccine|BIOLOGICAL: Measles, Mumps, Rubella and Varicella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Thyroid Cancer
Interventions: DRUG: Vemurafenib (All Groups)|DRUG: Vemurafenib (Post Surgery) - Group A + C|OTHER: Post Surgery - Group B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Aerobic and Cognitive Training System
Status: COMPLETED
Conditions: Healthy Aging
Interventions: BEHAVIORAL: Simultaneous exercise and cognitive training|BEHAVIORAL: Exercise training|BEHAVIORAL: Cognitive Training|BEHAVIORAL: Neutral video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Adjuvanted Seasonal Recombinant Quadrivalent Virus-Like Particles (QVLP) Influenza Vaccine in Adults 65 Years of Age and Older
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Instramuscular vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase I/II Follow-up Study of SAR422459 in Patients With Stargardt's Macular Degeneration
Status: ACTIVE_NOT_RECRUITING
Conditions: Stargardt's Disease
Interventions: DRUG: Long term follow up in all patients who received SAR422459 in previous study TDU13583
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phone-Based Postpartum Continuing Care for Smoking Cessation
Status: COMPLETED
Conditions: Smoking Cessation|Pregnancy
Interventions: BEHAVIORAL: Phone-based postpartum continuing care|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Maitland's Mobilization in Patients With Myofacial Chronic Neck Pain
Status: COMPLETED
Conditions: Myofascial Pain Syndrome of Neck
Interventions: OTHER: Maitland's mobilization|OTHER: Traditional Physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Stellate Ganglion Block in Obstructive Sleep Apnea
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: BEHAVIORAL: routine rehabilitation treatment|PROCEDURE: Stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Patient Satisfaction Using Autogenous Inlay (Sandwich) Eminoplasty Versus Patient Specific Poly Ether-ether Ketone (PEEK) Onlay Implant
Status: UNKNOWN
Conditions: Mandibular Dislocation
Interventions: DEVICE: PEEK eminoplasty|PROCEDURE: autogenous onlay grafting eminoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: L-carnitine supplementation|DIETARY_SUPPLEMENT: Leucine supplementation|PROCEDURE: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BEZ235 Trial in Patients With HER2-(Human Epidermal Growth Factor Receptor 2 Negative) /HR+ (Hormonal Receptor Positive) Metastatic Breast Cancer
Status: WITHDRAWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: BEZ235
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SLOG vs mFOLFIRINOX as the First-line Treatment in Locally Advanced Uncresectable or Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Locally Advanced or Metastatic Pancreatic Cancer
Interventions: DRUG: S-1|DRUG: Leucovorin(oral )|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: 5-FU|DRUG: Leucovorin(IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials to Reduce the Risk of Antimicrobial Resistance
Status: TERMINATED
Conditions: Bacterial Pneumonia
Interventions: DRUG: IV meropenem|DRUG: I.V. Meropenem|DRUG: Parenteral aminoglycoside; tobramycin for injection USP OR gentamicin sulfate injection solution concentrate 5mg.kg IV q24h; amikacin sulfate injection USP 20 mg/kg IV q24h|DRUG: Linezolid or Vancomycin (per institutional guidelines) will be available for MRSA coverage.|DEVICE: tobramycin nebulization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atomoxetine Versus Placebo for Symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in Children and Adolescents With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autistic Disorder|Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Safety, Tolerability and Efficacy of YM150 in Subjects With Acute Coronary Syndromes
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: YM150|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Treatment of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Carboplatin|DRUG: Nab-paclitaxel|DRUG: GM-CSF|DRUG: Trastuzumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-Approval Study of the Guidant Carotid Stent Systems and Embolic Protection Systems: CAPTURE
Status: COMPLETED
Conditions: Atherosclerotic Disease, Carotid
Interventions: DEVICE: RX ACCULINK(TM) Carotid Stent System and RX ACCUNET(TM) Embolic Protection System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Paracervical Vasopressin Injection Compared With Intramyometrial Vasopressin in Abdominal Myomectomy
Status: WITHDRAWN
Conditions: Myoma
Interventions: DRUG: Vasopressins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison
Status: UNKNOWN
Conditions: Parkinson's Disease|Dysarthria|Speech|Cross-language|Medical Treatment|Disease Progression
Interventions: OTHER: Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Digital Meditation for Postoperative Pain Control After Abdominal Surgery for Cancer
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Survey Administration|OTHER: Interview|OTHER: Text Message-Based Navigation Intervention|OTHER: Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A 12-Week Study With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Tenapanor for the Treatment of IBS-C
Status: COMPLETED
Conditions: Constipation Predominant Irritable Bowel Syndrome
Interventions: DRUG: Tenapanor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting Triple Negative BREAst Cancer Metabolism With a Combination of Chemoimmunotherapy and a FASTing-like Approach in the Preoperative Setting: the BREAKFAST 2 Trial
Status: RECRUITING
Conditions: Breast Cancer|Triple Negative Breast Cancer|Dietary Exposure|Fasting
Interventions: DIETARY_SUPPLEMENT: Control diet (ARM A) or Fasting-Like Approach (FLA, ARM B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions in Small Vessels
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: PROMUS Element Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Shang Ring Male Children Circumcision: Comparison Between Flip and No Flip Technique
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DEVICE: No flip technique of Shang Ring circumcision|DEVICE: Flip technique of Shang Ring circumcision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Response of Irritable Bowel Syndrome to Abdominal Fat Reduction
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Obesity|Abdominal Obesity
Interventions: PROCEDURE: focused ultrasound|BEHAVIORAL: Low Caloric Diet (LCD) and a low (FODMAPs) diet|OTHER: aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Mechanism of Repetitive Transcranial Magnetic Stimulation in Children With Autism Spectrum Disorders
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: repeated transcranial magnetic stimulation (continuous theta-burst stimulation)|DEVICE: sham repeated transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Effects of Preoperative Oral Domperidone on Gastric Residual Volume After Clear Fluid Ingestion in Patients Scheduled for Elective Surgeries
Status: COMPLETED
Conditions: Gastric Residual Volume
Interventions: DRUG: Domperidone|DRUG: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different States of Lipid in Food on Glycaemia, Lipaemia and Insulinaemia.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Cardiovascular Risk Factor
Interventions: OTHER: Cocoa butter|OTHER: Cocoa butter oleogel|OTHER: Sal seed oil|OTHER: Sal seed oleogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study To Compare The Amount Of Tasocitinib (CP-690,550) That Is Absorbed Into The Blood Of Healthy Subjects Following Oral Administration Of Three Different Tablet Versions Of Tasocitinib (CP-690,550)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment A|DRUG: Treatment C|DRUG: Treatment B|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment A|DRUG: Treatment C|DRUG: Treatment C|DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment B|DRUG: Treatment A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Developing New Clinical Management Strategies
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interstitial Cystitis: Elucidation of the Psychophysiologic and Autonomic Characteristics (ICEPAC) Study
Status: COMPLETED
Conditions: Interstitial Cystitis/Painful Bladder Syndrome|Myofascial Pelvic Pain
Interventions: DRUG: Bupivacaine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of the Effects of Classical Massage Application on Individuals With Chronic Low Back Pain
Status: NOT_YET_RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: Classical physiotherapy and classical massage|OTHER: Classical physiotherapy and placebo massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab In Combination With Cabozantinib in Patients With Non-Clear Cell Renal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Non-clear Cell Renal Cell Carcinoma|Unclassified Renal Cell Carcinoma|Papillary Renal Cell Carcinoma|Fumarate Hydratase Deficient Renal Cell Carcinoma|Succinate Dehydrogenase Deficient Renal Cell Carcinoma|Collecting Duct Renal Cell Carcinoma|Chromophobe Renal Cell Carcinoma
Interventions: DRUG: cabozantinib|DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-resolution Magnetic Resonance Imaging (MRI) Scans to Look for Spread of Melanoma to Nearby Lymph Nodes
Status: COMPLETED
Conditions: Melanoma
Interventions: PROCEDURE: High-resolution contrast-enhanced MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Virtual Reality as an Adjuvant Therapy for Sickle Cell Vaso-Occlusive Crisis in the Pediatric Emergency Department
Status: COMPLETED
Conditions: Sickle Cell Crisis
Interventions: OTHER: Virtual Reality Goggles
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Mesenchymal Stem Cells for Patients With Liver Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: DRUG: conventional plus MSC treatment|DRUG: conventional plus placebo treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Split-course SBRT for Borderline Resectable and Locally Advanced Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Neoplasms
Interventions: DRUG: nab-Paclitaxel+Gemcitabine|RADIATION: split-course SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liquid Biopsy (ctDNA) Guided Treatment in Localized Pancreatic Cancer: Neoadjuvant CTX vs. Upfront Surgery
Status: RECRUITING
Conditions: Pancreatic Cancer|Circulating Tumor Cell|Predictive Cancer Model
Interventions: PROCEDURE: Neoadjuvant chemotherapy instead of upfront surgery|PROCEDURE: Upfront surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teaching Associates Randomised to Evaluate the Effectiveness of Gynaecological Pelvic Examination Versus Traditional Teaching Using Manikins
Status: COMPLETED
Conditions: Female Pelvic Examination
Interventions: BEHAVIORAL: Gynaecology Teaching Associates (GTA's)|BEHAVIORAL: Manikin (conventional) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Safety of Ramelteon in Subjects With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Ramelteon and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Application of Portable Intelligent Multi Joint Isokinetic Training and Evaluation System Technology
Status: RECRUITING
Conditions: Stroke|Hemiplegia|Rehabilitation; Tobacco Use|Physical Disability
Interventions: DEVICE: Intelligent portable isokinetic muscle strength test training|DEVICE: isokinetic muscle strength test training|OTHER: without test training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Positioning of Molecular Markers in Clinical Routine for the Management of Patients With Adrenal Cancers/Tumors (COMETE-CARE)
Status: RECRUITING
Conditions: Cancer|Adrenal
Interventions: OTHER: Blood sample|OTHER: Urine sample|OTHER: Tumor sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 9-ING-41 in Pediatric Patients With Refractory Malignancies.
Status: RECRUITING
Conditions: Refractory Cancer|Refractory Neoplasm|Cancer Pediatric|Refractory Tumor|Pediatric Cancer|Pediatric Brain Tumor|Neuroblastoma|Neuroblastoma Recurrent|Pediatric Lymphoma|Pediatric Meningioma|Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: 9-ING-41|DRUG: Irinotecan|DRUG: Temozolomide|DRUG: Cyclophosphamide|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Biodistribution, Internal Radiation Dosimetry, and Effective Dose of DaTSCAN™ Ioflupane (123I) Injection in Chinese Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy Subjects (HS)
Interventions: DRUG: DaTSCAN™ Ioflupane (123I) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Arrhythmic Effects of Hight Dose Caffeine
Status: UNKNOWN
Conditions: Arrhythmia
Interventions: DIETARY_SUPPLEMENT: caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Benzydamine Hydrochloride Gargle in Reducing Propofol for ERCP
Status: COMPLETED
Conditions: ERCP
Interventions: DRUG: Benzydamine Hydrochloride 0.15% Oral Rinse|DRUG: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rapid Pleurodesis Through an Indwelling Pleural Catheter
Status: TERMINATED
Conditions: Pleural Effusion, Malignant|Pleurodesis|Pleural Diseases
Interventions: DRUG: Rapid pleurodesis protocol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E-Based Technology to Provide Decision Aid on Breast Reconstruction for Women With Breast Cance
Status: UNKNOWN
Conditions: Decision Support Technique|Breast Cancer
Interventions: OTHER: E-based & personalized breast reconstruction surgery decision aid|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Creatine Use and Muscle Stretching in Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Creatine monohydrate|DIETARY_SUPPLEMENT: Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Distraction in Pediatric Patients.
Status: NOT_YET_RECRUITING
Conditions: Virtual Reality|Distraction|Infiltration Anesthesia|Pediatric Patients
Interventions: DEVICE: Virtual reality goggles (VR )|DEVICE: regular screen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress
Status: COMPLETED
Conditions: Depressive Disorder|Anxiety
Interventions: DRUG: JNJ-42165279|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Geriatric Assessment Directed Trial to Evaluate Gemcitabine +/- Nab-paclitaxel in Elderly Pancreatic Cancer Patients
Status: COMPLETED
Conditions: Adenocarcinoma Pancreas
Interventions: DRUG: Nab-paclitaxel|DRUG: Gemcitabine|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of AQUAVAN® (Fospropofol Disodium) Injection for Sedation During Minor Surgical Procedures.
Status: COMPLETED
Conditions: Procedural Sedation
Interventions: DRUG: AQUAVAN® (fospropofol disodium) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery
Status: RECRUITING
Conditions: Postoperative Delirium|Elderly Patients
Interventions: DRUG: S-ketamine|DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Total Underwater Colonoscopy (TUC) for Improved Colorectal Cancer Screening: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Colorectal Neoplasia|Screening Colonoscopy|Colorectal Cancer|Colorectal Cancer Screening|Vasovagal Reaction
Interventions: PROCEDURE: Total underwater colonoscopy|PROCEDURE: Conventional colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Conventional Antibiotic Prophylaxis Versus Add-On 5 Days Levofloxacin Before Percutaneous Nephrolithotomy
Status: UNKNOWN
Conditions: Percutaneous Nephrolithotomy|Infection|Sepsis|Antibiotics
Interventions: DRUG: Levofloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Bevacizumab Followed by Bevacizumab Consolidation for Ovarian Cancer
Status: COMPLETED
Conditions: Advanced Ovarian Carcinoma|Primary Peritoneal Carcinoma|Ovarian Carcinosarcoma
Interventions: DRUG: Avastin|DRUG: Paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study
Status: RECRUITING
Conditions: Total Knee Replacement|Knee Arthroplasty
Interventions: DRUG: Bupivacaine-Liposomal Bupivacaine|DRUG: Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pediatric Pilot Study: Irrigation and Scrubbing in Facial and Scalp Wounds
Status: WITHDRAWN
Conditions: Facial and Scalp Lacerations
Interventions: PROCEDURE: Irrigation|PROCEDURE: No irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Topical Human FGF-1 for Wound Healing
Status: UNKNOWN
Conditions: Diabetic Foot Ulcers
Interventions: DRUG: FGF-1 141|DRUG: FGF-1 141
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy of SPD503 in Treating ADHD in Children Aged 6-17
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: SPD503 (Guanfacine HCl)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Postoperative Pain After Ambulatory Surgery
Interventions: DRUG: PCM/Oxy1|DRUG: PCM/Oxy2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Management for TA-BSM in HOCM
Status: COMPLETED
Conditions: Anesthesia|Transapical Beating-heart Septal Myectomy|Hypertrophic Cardiomyopathy
Interventions: PROCEDURE: transapical beating-heart septal myectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metronomic Treatment With Daily Oral Vinorelbine as First-line Chemotherapy in Patients With Advanced/Metastatic Hormone Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate the Safety and Efficacy for Levacalm Tab. Versus Valsartan/Amlodipine Combination Therapy in Essential Hypertension Patients
Status: UNKNOWN
Conditions: Lower Leg Edema|Orthostatic Hypertension
Interventions: DRUG: Levacalm|DRUG: Valsartan/amlodipine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Thermocool SF Catheter on the Common Cavo-tricuspid Isthmus Dependent Atrial Flutter Ablation
Status: UNKNOWN
Conditions: Atrial Flutter.
Interventions: DEVICE: CelsiusTMDS® 8 mm catheter|DEVICE: Thermocool® 3.5 mm catheter of irrigated tip|DEVICE: Thermocool® SF catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment Thrombolysis in Myocardial Infarction - Study 25 (ExTRACT-TIMI25)
Status: COMPLETED
Conditions: Myocardial Infarction|Acute ST-Segment Elevation
Interventions: DRUG: Enoxaparin sodium (XRP4563)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Statin Therapy on Coronary Flow Reserve and Inflammatory Markers in HIV-Positive Patients
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV)|Cardiovascular Disease (CVD)
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of ProTectis on Infant Colic and Its Effect on Infant Crying Time and Maternal Mental Health
Status: UNKNOWN
Conditions: Infantile Colic|Infant Sleeping Habits|Maternal Mental Health.
Interventions: OTHER: ProTectis drops (five drops per day) for 21 days|OTHER: Placebo drops (five drops per day) for 21 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ticagrelor in Methotrexate-Resistant Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Ticagrelor|DRUG: MTX therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Septra for Uncomplicated Skin Abscesses in Patients at Risk for Community Acquired Methicillin-Resistant Staphylococcus Aureus Infection
Status: COMPLETED
Conditions: Abscess|Methicillin-Resistant Staphylococcus Aureus Infection
Interventions: DRUG: Trim/ Sulfa DS|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: DRUG: amoxicillin/clavulanate postassium (Augmentin ES-600)|DRUG: azithromycin SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Progestin-primed Ovarian Stimulation Protocol Versus GnRH Antagonist Protocol in Polycystic Ovary Syndrome Patients Undergoing IVF/ICSI Cycles
Status: UNKNOWN
Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Interventions: DRUG: Dydrogesterone Tablets|DRUG: cetrorelix 0.25mg|DRUG: human menopausal gonadotropin|DRUG: triptorelin 0.1 mg|DRUG: human chorionic gonadotropin|PROCEDURE: cryopreservation|DRUG: Estradiol Valerate and progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Intravaginal Prasterone (Intrarosa®) in Postmenopausal Vulvovaginal Atrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Postmenopausal Vulvovaginal Atrophy
Interventions: DRUG: intravaginal prasterone|DRUG: Placebo ovules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolaemia
Interventions: DRUG: alirocumab SAR236553 (REGN727)|DRUG: statins|DRUG: ezetimibe|DRUG: cholestyramine|DRUG: fenofibrate|DRUG: omega-3 fatty acids|DRUG: nicotinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Gabapentin for Post-Covid-19 Olfactory Dysfunction
Status: COMPLETED
Conditions: COVID-19|Olfactory Disorder|Anosmia|Hyposmia|Parosmia
Interventions: DRUG: Gabapentin gelatin capsules 300mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Treatment of Pathological Fractures in Humerus
Status: COMPLETED
Conditions: Humerus Fracture Metastatic Bone Disease
Interventions: DEVICE: Photodynamic Bone Stabilization System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Pilot Study Examining the Use of Rituximab in Patients With Wegener's Granulomatosis Who Have Experienced Disease Relapse on Standard Therapies
Status: COMPLETED
Conditions: Wegener's Granulomatosis
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Using Topically Applied Glyceryl Trinitrate (GTN) for the Treatment of Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: MED2005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Classroom Study of SPN-812 in Children With ADHD
Status: WITHDRAWN
Conditions: ADHD
Interventions: DRUG: Placebo|DRUG: 200 mg SPN-812
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration
Status: ACTIVE_NOT_RECRUITING
Conditions: Age-related Macular Degeneration|Geographic Atrophy
Interventions: BIOLOGICAL: VOY-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Medication vs. Prostatic Urethral Lift: Assessment and Comparison of Therapies for BPH
Status: RECRUITING
Conditions: BPH
Interventions: DEVICE: UroLift System|DRUG: Tamsulosin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: R348 Ophthalmic Solution, 0.2%|DRUG: R348 Ophthalmic Solution, 0.5%|DRUG: R348 Ophthalmic Solution, 1.0%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients
Status: COMPLETED
Conditions: Ischemic Brain Injury
Interventions: DRUG: xenon|OTHER: Hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Speech Motor Learning and Retention (Master Protocol)
Status: NOT_YET_RECRUITING
Conditions: Speech
Interventions: DEVICE: continuous theta-burst stimulation (cTBS)|BEHAVIORAL: Adaptation|DEVICE: Single pulse Transcranial magnetic stimulation (TMS)|DEVICE: fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction
Status: RECRUITING
Conditions: Anesthesia
Interventions: DRUG: MTPI|DRUG: Classic Induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Blood Transplant for Hematological Malignancies
Status: COMPLETED
Conditions: CML|AML|MDS|ALL|NHL|Multiple Myeloma|Hodgkin's Disease
Interventions: BIOLOGICAL: Ex Vivo CD3/CD28 costimulated Umbilical Cord Blood T cells|OTHER: Observation Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Erythropoietin (EPO) in Kidney After Cardiac Surgery
Status: COMPLETED
Conditions: Kidney Failure, Acute
Interventions: DRUG: Erythropoietin-Beta|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Varenicline and Nicotine Interactions in Humans (VA)
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: Varenicline|DRUG: Placebo|DRUG: IV Nic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of MW02 in the Treatment of nAMD
Status: UNKNOWN
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: MW02|DRUG: Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLO
Status: TERMINATED
Conditions: Thalassemia
Interventions: DRUG: Busulfan|DRUG: Fludarabine|DRUG: Campath 1H|DRUG: Cyclophosphamide|DRUG: MESNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEF-Block & Ribs Fractures
Status: COMPLETED
Conditions: Chest Trauma With Ribs Fractures
Interventions: PROCEDURE: Intravenous morphine patient-controlled analgesia (PCA)|PROCEDURE: Block of the posterior exo-thoracic fascia with Ropivacaine|PROCEDURE: Block of paravertebral space with Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilizing Multiomic Advanced Diagnostics to Identify CDK 4/6 Inhibitor Response Predictors and a Post-treatment Multiomic Signature for Patients With ER+/HER2- Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: OTHER: biomarker study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 8 Continuous vs 8 Intermittent Cycles in First and Second Line in HER2/Neu Neg Metastatic Breast Cancer
Status: COMPLETED
Conditions: Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Metastatic Breast Cancer
Interventions: DRUG: Paclitaxel, Bevacizumab, liposomal doxorubicin, Capecitabine|DRUG: Paclitaxel, Bevacizumab, liposomal doxorubicin, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer
Status: COMPLETED
Conditions: Advanced Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Curcumin|DRUG: Paclitaxel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy of Andrographis Paniculata in Subjects With Mild to Moderate Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Andrographis Paniculata|DIETARY_SUPPLEMENT: Andrographis Paniculata
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart
Status: COMPLETED
Conditions: Idiopathic Dilated Cardiomyopathy
Interventions: DRUG: Carvedilol|DRUG: Metoprolol succinate|DRUG: Metoprolol succinate + doxazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Clinician Virtual Human Interaction Training in Emotional Self-Awareness on Patients Suicidal Ideation and Suicide Crisis Syndrome
Status: COMPLETED
Conditions: Suicide
Interventions: BEHAVIORAL: Emotional Self Awareness (ESA) Individual Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Intravenous Ibuprofen on Acute Pain After Laparoscopic Cholecystectomy
Status: NOT_YET_RECRUITING
Conditions: Cholecystitis/Cholelithiasis
Interventions: PROCEDURE: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Mountain Sickness, Systemic Vascular Function
Status: UNKNOWN
Conditions: Mountain Sickness|Chronic
Interventions: DIETARY_SUPPLEMENT: Vitamin C and E|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of a Mode of Vitamin D Supplementation (Sequential Dose vs Daily Dose) on the Incidence of Hypercalciuria in Subjets Aged From 2 to 18 Years
Status: RECRUITING
Conditions: Transient Hypercalciuria
Interventions: DRUG: Cholecalciferol sequential dose|DRUG: Cholecalciferol daily dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Chiauranib for Advanced Solid Malignant Tumors and Relapsed/Refractory SCLC.
Status: RECRUITING
Conditions: Small Cell Lung Cancer|Advanced Solid Malignant Tumor
Interventions: DRUG: Chiauranib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Administration of Lactose-free Milk in Children Presenting With Acute Diarrhea
Status: COMPLETED
Conditions: Acute Diarrhea
Interventions: DIETARY_SUPPLEMENT: lactose-free milk|DIETARY_SUPPLEMENT: conventional milk
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interactive Digital Game for Improving Visual Perceptual Defects in Children With Developmental Disability
Status: COMPLETED
Conditions: Developmental Disability
Interventions: DEVICE: Visual-perceptual interactive game system|BEHAVIORAL: standard rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cocaine Use Reduction With Buprenorphine
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Buprenorphine + Naltrexone|DRUG: Placebo + Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S0000 Selenium and Vitamin E in Preventing Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Vitamin E|DRUG: Selenium|OTHER: Vitamin E placebo|OTHER: selenium placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION