pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Targeting Vascular Reactivity in Idiopathic Pulmonary Fibrosis
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis|Pulmonary Fibrosis
Interventions: DRUG: Sildenafil|DRUG: Losartan|DRUG: Sildenafil and Losartan|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Russian Evaluation of Lp(a) Role in cardiovascUlar DiseasE
Status: COMPLETED
Conditions: Coronary Disease|Cardiovascular Diseases
Interventions: PROCEDURE: percutaneous coronary intervention|PROCEDURE: coronary artery bypass grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair
Status: RECRUITING
Conditions: Hiatal Hernia
Interventions: DEVICE: Biosynthetic Mesh|PROCEDURE: Hiatal Hernia Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Opioid-use Disorder
Interventions: DRUG: Sofosbuvir/Velpatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Orange Oil Aromatherapy on the Pain and Anxiety
Status: COMPLETED
Conditions: Hematopoietic Transplantation|Bone Marrow Transplantation
Interventions: OTHER: Orange oil aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of Stem Cells
Status: COMPLETED
Conditions: Anal Fistula
Interventions: DRUG: ◦Drug: ASCs. + fibrin glue|DRUG: fibrin glue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Efficacy and Safety of Docetaxel and Doxorubicin With INGN 201 in Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Locally Advanced Breast Cancer (LABC)
Interventions: GENETIC: INGN 201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BicepsTenodesis vs. Biceps Debridement in Combined RC Tears and SLAP Lesions
Status: TERMINATED
Conditions: SLAP Lesion
Interventions: PROCEDURE: Biceps Tenodesis|PROCEDURE: Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biseko Versus Albumin in Systemic Inflammatory Response Syndrome (SIRS) Patients
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome
Interventions: DRUG: Albumin (5% serum-protein solution containing immunoglobulins)|DRUG: Biseko
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Effectiveness and Safety of Tramadol HCl/Acetaminophen Versus Placebo for the Treatment of Painful Neuropathy in Diabetic Patients
Status: COMPLETED
Conditions: Diabetic Neuropathies
Interventions: DRUG: tramadol, acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Novel Patient Educational Booklet on Colonoscopy Quality
Status: COMPLETED
Conditions: Colon Cancer|Colonoscopy
Interventions: OTHER: Receiving an educational booklet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intravitreal Injection Anesthesia - Comparison of Different Topical Agents
Status: COMPLETED
Conditions: Age-Related Macular Degeneration (AMD)
Interventions: DRUG: Tetracaine|DRUG: Cocaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-interventional Study of Kyprolis® in Combination With Revlimid® and Dexamethasone or Dexamethasone Alone or in Combination With Darzalex® and Dexamethasone in Multiple Myeloma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma in Relapse
Interventions: DRUG: Carfilzomib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Muscles Oxygenation During Exercise in Fibrosing Interstitial Lung Diseases
Status: COMPLETED
Conditions: Lung Diseases, Interstitial|Exercise, Compulsive|Oxygen Deficiency
Interventions: OTHER: NIRS device usage during 6MWT|OTHER: Peripheral Muscle Strength Measurement|OTHER: Pulmonary Function Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multiple Ascending Oral Dose Evaluation of the Safety, Tolerability, and Pharmacokinetics of DSP-1053 and Its Metabolites in Healthy Subjects and in Subjects With Major Depressive Disorder
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: DSP-1053|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lactobacillus Johnsonii Supplementation in Adults With T1D
Status: RECRUITING
Conditions: Type 1 Diabetes (T1D)
Interventions: DRUG: L. johnsonii Probiotic|DRUG: Placebo Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study To Evaluate Safety and Efficacy of Vesatolimod for the Treatment of Chronic Hepatitis B Virus in Virally-Suppressed Participants
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Vesatolimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection
Status: COMPLETED
Conditions: Clostridium Difficile Infection
Interventions: BIOLOGICAL: RBX2660|DRUG: Standard of Care Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Motivational Interviewing for Loved Ones
Status: COMPLETED
Conditions: Psychotic Disorders|Psychosis|Psychotic Episode
Interventions: BEHAVIORAL: Motivational Interviewing for Loved Ones (MILO)|BEHAVIORAL: Mental Health Services Consultation and Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Induced Gait Variability
Status: COMPLETED
Conditions: Opioid Induced Motor Disturbances
Interventions: DRUG: Tapentadol 50 mg Oral Tablet|DRUG: Tramadol Hydrochloride 100 mg Extended Release Oral Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Radiofrequency Power for Faster and Safer Pulmonary Vein Ablation Trial (POWER FAST III)
Status: COMPLETED
Conditions: Atrial Fibrillation|Catheter Ablation
Interventions: OTHER: High-power and short-duration radiofrequency ablatio (70 W / 9-10 s)|OTHER: Low-power (25-40 W) radiofrequency ablation guided by lesion size index (LSI) and ablation index (AI) values|OTHER: Esophageal endoscopy|DIAGNOSTIC_TEST: Daily 30-seconds ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Neuro Hand Orthosis Program In Stroke Upper Limb Rehabilitation
Status: UNKNOWN
Conditions: Paralytic Stroke
Interventions: OTHER: Conventional upper limb stroke rehabilitation|DEVICE: Neuro Hand Orthosis Program (NHOP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Novel Trend Arrow Adjustment Tool for Diabetes Patients Using Continuous Glucose Monitoring to Guide Insulin Bolus Adjustment (TAAT Study)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: OTHER: Trend Arrow Adjustment Tool|OTHER: 10/20% bolus adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Analgesic Effects of PF-06273340 in Healthy Volunteers Using Evoked Pain Endpoints
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06273340|DRUG: PF-06273340|DRUG: Pregabalin|DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Permanent Right Internal Mammary Artery Occlusion on Extracardiac Coronary Collateral Supply
Status: COMPLETED
Conditions: Circulation, Collateral|Coronary Artery Disease|Internal Mammary-Coronary Artery Anastomosis|Ischemia
Interventions: DEVICE: Amplatzer vascular plug|OTHER: Sham Controll
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Meshed Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects
Status: NOT_YET_RECRUITING
Conditions: Gingival Recession, Localized
Interventions: PROCEDURE: Coronally Advanced Flap combined with a Connective Tissue Graft|PROCEDURE: Coronally Advanced Flap combined with a Meshed Connective Tissue Graft|DEVICE: Meshing of Connective Tissue Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ 10229570-AAA to Evaluate Safety and Tolerability in Japanese Participants With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: JNJ 10229570-AAA 1.2%|DRUG: JNJ 10229570-AAA 3.6%|DRUG: Color-matched vehicle containing 0 mg of JNJ 10229570-AAA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Roof Linear, Mitral Isthmus Linear and Left Anterior Septal Linear Ablation for Non-paroxysmal AF: PROMISED Trial.
Status: RECRUITING
Conditions: Atrial Fibrillation|Atrial Fibrillation, Persistent
Interventions: PROCEDURE: PROMISED|PROCEDURE: CPVI and LAAC|DEVICE: Radiofrequency ablation catheter|DEVICE: left atrial appendage occlusion device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Body, Liver and Labile Plasma Iron and Their Association With Outcome and Immunological Recovery in Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) Patients Undergoing Allogeneic Stem Cell Transplantation - ALLIVE (ALLogeneic Iron inVEstigators) Observational Trial
Status: COMPLETED
Conditions: MDS and AML Prior to Allogeneic SCT
Interventions: OTHER: No intervention and study treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Alirocumab and Plaque Regression in Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DRUG: Alirocumab|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Efficacy and Tolerability of a Lactic Acid Containing Vaginal Suppository in Post-menopausal Women With VVA
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DRUG: WO533
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Investigation Evaluating Two Abutment Surfaces
Status: NOT_YET_RECRUITING
Conditions: Peri-implant Crevicular Fluid
Interventions: DIAGNOSTIC_TEST: Immunological and microbiological sample of peri-implant crevicular fluid; clinical evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of the Administration of Ondansetron Versus Habitual Clinical Practice for the Treatment of Vomiting in Children With Mild and Moderate Dehydration: Randomized Clinical Trial
Status: UNKNOWN
Conditions: Vomiting in Infants and/or Children
Interventions: DRUG: Ondansetron 4 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Efficacy and Safety of Topiramate OROS Controlled-Release in Obese, Type 2 Diabetic Subjects Managed With Diet or Metformin
Status: COMPLETED
Conditions: Obesity|Diabetes Mellitus, Type 2|Diabetes Mellitus, Adult-Onset
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Versus Blind Technique in Medial Brachial Cutaneous Nerve and Intercostobrachial Nerve Blocks
Status: COMPLETED
Conditions: Upper Limb Surgery
Interventions: PROCEDURE: medial brachial cutaneous nerve block and intercostobrachial nerve block with blind technique|PROCEDURE: medial brachial cutaneous nerve block and intercostobrachial nerve block with ultrasound-guided technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Additivity Study: Additive Effect on Eye Pressure of Azopt and Alphagan P to Travatan
Status: COMPLETED
Conditions: Open Angle Glaucoma|Ocular Hypertension|Pseudoexfoliation Syndrome
Interventions: DRUG: Travatan|DRUG: Azopt|DRUG: Alphagan P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of the Theranostic Pair [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G in Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Cancer|Locally Advanced Pancreatic Adenocarcinoma
Interventions: DRUG: [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor in Combination With MTX+Ritu to Treat R/R CNSL
Status: RECRUITING
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: Selinexor|DRUG: Rituximab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: DRUG: Memantine|DRUG: bupropion|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Enteral Nutrient Delivery: A Prospective Randomized Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Sucrose plus Whole Milk Powder in Enteric Coating|DIETARY_SUPPLEMENT: Non coated Sucrose plus Whole Milk|DIETARY_SUPPLEMENT: Sucrose in Enteric Coating|DIETARY_SUPPLEMENT: Sucrose with Separate Enteric Coating Materials|DIETARY_SUPPLEMENT: Whey Protein in Enteric Coating|DIETARY_SUPPLEMENT: Whey Protein with Separate Enteric Coating Materials|DIETARY_SUPPLEMENT: Pea Protein in Enteric Coating|DIETARY_SUPPLEMENT: Pea Protein with Separate Enteric Coating Materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: BMS-9894923
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quetiapine and Concerta in the Treatment for ADHD and Aggressive Behavior.
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Oros Methylphenidate|DRUG: quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study on Extranodal Lymphoma or Lymphoma of Rare Pathological Types
Status: NOT_YET_RECRUITING
Conditions: Lymphoma|Extranodal Lymphoma|Diffuse Large B Cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Marginal Zone Lymphoma|Mucosa-Associated Lymphoid Tissue Lymphoma|NK/T-Cell Lymphoma, Nasal and Nasal-Type|Intravascular Large B-Cell Lymphoma
Interventions: OTHER: No interventions need to be specified for this study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-centre Observational Registry on Patients With Implantable Devices Remotely Monitored
Status: UNKNOWN
Conditions: Defibrillators, Implantable|Heart Failure With Reduced Ejection Fraction|Arrythmia|Pacemaker
Interventions: DEVICE: Assesment of outcome of implantable device patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aliskiren in Combination With Amlodipine in Hypertensive Patients Not Responding to Angiotensin Receptor Blocker (ARB) Plus Amlodipine
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Aliskiren/Amlodipine and Aliskiren/Amlodipine/HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 2-Part, Phase 2 Open-label and Crossover Study of Belumosudil for Treatment of Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Belumosudil|OTHER: BSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic KT on Pulmonary Function Ichildren With Pneumonia
Status: NOT_YET_RECRUITING
Conditions: Pneumonia Childhood
Interventions: OTHER: kinesotape|BEHAVIORAL: Chest physiotherapy exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of KeraStat Cream for Radiation Dermatitis During Head and Neck Radiotherapy
Status: COMPLETED
Conditions: Head and Neck Cancer|Radiation Dermatitis
Interventions: DEVICE: KeraStat Cream|OTHER: Routine Skin Care - Commercially Available Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tele-rehabilitation in Subjects With Congenital and Acquired Developmental Disabilities
Status: RECRUITING
Conditions: Congenital and Acquired Developmental Disabilities
Interventions: DEVICE: VRRS Home Tablet or Medico Amico Kids APP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Priming of the NEonatal Immune System by Transfer of Maternal Immunity
Status: UNKNOWN
Conditions: COVID-19|Maternal Vaccine Exposure|Respiratory Infections in Children
Interventions: BIOLOGICAL: Tozinameran|OTHER: COVID-19|OTHER: No SARS-CoV-2 exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Study: Evaluate the Effectiveness of Using a Topical Anesthetic Prior to Ultherapy™ Treatment
Status: COMPLETED
Conditions: Skin Laxity
Interventions: DRUG: L.M.X.4.® cream|OTHER: A placebo cream|DEVICE: Ulthera System Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: methotrexate|DRUG: vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Maximum Tolerated Dose, Safety and Effectiveness of Pomalidomide for Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Anemia, Sickle Cell
Interventions: DRUG: pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Tolerability of Iberdomide (CC-220) in Participants With Kidney Impairment Compared to Participants With Normal Kidney Function
Status: COMPLETED
Conditions: Renal Insufficiency
Interventions: DRUG: Iberdomide|DRUG: Iberdomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Customized Headrest or Standard Headrest in Holding Patients Still While Undergoing Radiation Therapy for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: OTHER: questionnaire administration|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: radiation therapy treatment planning/simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19 and CD22 Dual-targeted CAR-T Cells for Relapsed or Refractory B-NHL
Status: UNKNOWN
Conditions: B-cell Lymphoma Refractory|B-cell Lymphoma Recurrent
Interventions: BIOLOGICAL: CD19 and CD22 targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Performance Evaluation of NU-FlexSIV Socket
Status: COMPLETED
Conditions: Amputation|Artificial Limbs
Interventions: DEVICE: Northwestern University Flexible Sub-Ischial Vacuum Socket|DEVICE: Ischial Containment Socket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Disease|Myocardial Infarction|Stroke|Coronary Revascularization
Interventions: DRUG: Evolocumab|DRUG: Routine Lipid Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Peripheral T-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia
Interventions: DRUG: panobinostat|OTHER: laboratory biomarker analysis|GENETIC: western blotting|GENETIC: DNA analysis|OTHER: flow cytometry|OTHER: pharmacological study|OTHER: immunohistochemistry staining method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vivax Elimination With Tafenoquine (VET) Study
Status: NOT_YET_RECRUITING
Conditions: Malaria|Malaria, Vivax|Plasmodium Vivax|Plasmodium Vivax Malaria
Interventions: DRUG: Tafenoquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Study of BEZ235 and Trastuzumab in Patients With HER2-positive Breast Cancer Who Failed Prior to Trastuzumab
Status: COMPLETED
Conditions: Locally Advance Breast Cancer (LABC)|Metastatic Breast Cancer (MBC)
Interventions: DRUG: BEZ235 + Trastuzumab Phase l/Phase ll)|DRUG: Lapatinib + Capecitabine (Phase II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-centre Study of MBVD in Elderly and/or Cardiopathic Patients Affected by Hodgkin's Lymphoma (HL)
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: MBVD (Myocet+BVD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency
Status: COMPLETED
Conditions: Primary Immune Deficiency Disorders|Common Variable Immunodeficiency|X-linked Agammaglobulinemia|Hyper-IgM Syndrome|Wiskott-Aldrich Syndrome
Interventions: BIOLOGICAL: Gammaplex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LIRA-ADD2SGLT2i - Liraglutide Versus Placebo as add-on to SGLT2 Inhibitors.
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3)
Status: ENROLLING_BY_INVITATION
Conditions: Bronchiolitis Obliterans|Obliterative Bronchiolitis|Bronchiolitis Obliterans Syndrome
Interventions: DRUG: Liposomal Cyclosporine A 5 mg|DRUG: Liposomal Cyclosporine A 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psilocybin for Treatment of Obsessive Compulsive Disorder
Status: COMPLETED
Conditions: Obsessive-compulsive Disorder (OCD)
Interventions: DRUG: Psilocybin 100 mcg/kg|DRUG: Psilocybin 300 mcg/kg|DRUG: Lorazepam 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus
Status: UNKNOWN
Conditions: GDM
Interventions: DEVICE: FreeStyle sensors.|DEVICE: Glucometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Effects Kinesiotaping (KT) on Balance and Gait in Parkinson's Disease (DP)
Status: UNKNOWN
Conditions: Parkinson Disease|Kinesiotaping
Interventions: OTHER: Kinesiotaping|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Ketamine in Treatment-Resistant Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Efficacy and Safety of Drug Eluting vs. Bare-Metal Stents for Saphenous Vein Graft Interventions
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Drug eluting stent|DEVICE: Bare metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Epcoritamab for the Treatment of Previously Untreated Follicular Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|OTHER: Electronic Health Record Review|BIOLOGICAL: Epcoritamab|DRUG: Lenalidomide|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coblation Versus Cold Adenoidectomy -Safety and Efficiency
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: coblation (COBLATION II surgery system ,CE8001-01)|DEVICE: cold dissection adenoidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Traditional Chinese Medicine Formula in the Treatment of Osteoarthritis of Knees or Hips.
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: JING CEIH SHERN YUAN EXTRACT PILL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PROfiling Based Endometrial Cancer Adjuvant Therapy
Status: RECRUITING
Conditions: Endometrial Cancer Stage I|Endometrial Cancer Stage II
Interventions: RADIATION: Vaginal brachytherapy|RADIATION: External beam radiotherapy|OTHER: Observation|COMBINATION_PRODUCT: Chemoradiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profile of Glepaglutide After a Single Injection in Subjects With Varying Degrees of Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Glepaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Naloxone in Reducing Postictal Central Respiratory Dysfunction in Patients With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: naloxone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)
Status: COMPLETED
Conditions: CNS Lesion|Blood Brain Barrier Defect
Interventions: DRUG: gadopiclenol|DRUG: Gadobutrol 1Mmol/mL Solution for Injection Vial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomarker Study of Immune-mediated Mechanism of Action of Neoadjuvant Trastuzumab in HER2+ Breast Cancer Patients
Status: UNKNOWN
Conditions: Cancer, Breast
Interventions: BIOLOGICAL: Trastuzumab IV|BIOLOGICAL: Trastuzumab SC|BIOLOGICAL: Pertuzumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Application and Translational Research of 3D Printed in Treatment of Choledocholithiasis Under ERCP
Status: NOT_YET_RECRUITING
Conditions: Common Bile Duct Calculi
Interventions: OTHER: 3D printed models
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Farnesyl Protein Transferase Inhibitor (FPTI) in Combination With Docetaxel in Advanced Solid Tumors (Study P01964)(COMPLETED)
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Farnesyl Protein Transferase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Treatment of Neurogenic Bladder by Electroacupuncture on Ba Liao Point Under Ultrasound Guidance
Status: RECRUITING
Conditions: To Investigate the Clinical Effect of Acupuncturing Ba Liao for Neurogenic Bladder Under the Guidance of Ultrasound
Interventions: OTHER: Acupuncturing Ba Liao point under ultrasound guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravascular Access in Suspected/Confirmed COVID-19 Patient
Status: COMPLETED
Conditions: Emergency Medicine|Cardiopulmonary Arrest|Shock
Interventions: DEVICE: NIO® (Intraosseous access)|DEVICE: Standard of Care (Intravenous access)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Look at How a New Medicine Called NNC6019-0001 Works and How Safe it is for People Who Have Heart Disease Due to Transthyretin (TTR) Amyloidosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Interventions: DRUG: NNC6019-0001|DRUG: Placebo (NNC6019-0001)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Lactobacillus Plantarum GUANKE (CGMCC NO.21720) in Enhancement of Antibody Level After SARS-CoV-2 Vaccination (Trial 2)
Status: COMPLETED
Conditions: SARS-CoV-2
Interventions: DIETARY_SUPPLEMENT: 1 week placebo(Week 1)|DIETARY_SUPPLEMENT: 1 week of probiotics(Week 1)|DIETARY_SUPPLEMENT: 1 week placebo(Week 2)|DIETARY_SUPPLEMENT: 1 week of probiotics(Week 2)|DIETARY_SUPPLEMENT: 1 week placebo(Week 3)|DIETARY_SUPPLEMENT: 1 week of probiotics(Week 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL
Status: COMPLETED
Conditions: Cutaneous T-Cell Lymphoma/Mycosis Fungoides
Interventions: DRUG: Hypericin|DRUG: Mechlorethamine Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia
Status: RECRUITING
Conditions: Plasma Cell Leukemia|Recurrent Multiple Myeloma|Refractory Multiple Myeloma
Interventions: PROCEDURE: Biospecimen Collection|DEVICE: High Throughput Screening|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tositumomab and Iodine I 131 Tositumomab in Treating Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma in First Remission
Status: COMPLETED
Conditions: Lymphoid Leukemia in Remission|Stage I Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage III Small Lymphocytic Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Small Lymphocytic Lymphoma
Interventions: COMBINATION_PRODUCT: Tositumomab and Iodine I 131 Tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Megadose of Hydroxocobalamin for the Treatment of Pernicious Anemia
Status: COMPLETED
Conditions: Megaloblastic Anemia Nos|Pernicious Anemia
Interventions: DRUG: Hydroxocobalamin 10,000mcg, Thiamin 100mg, Pyridoxine 50mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study)
Status: COMPLETED
Conditions: Acute Respiratory Infections (ARIs)
Interventions: BEHAVIORAL: Clinical Decision Support (CDS): Accountable Justifications|BEHAVIORAL: Audit and Feedback: Peer Comparison|BEHAVIORAL: CDS Order Sets: Suggested Alternatives
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Endobronchial Ultrasound-Guided Biopsy Using Fine Needle Aspiration Versus Fine Needle Capillary Sampling
Status: COMPLETED
Conditions: Lymphadenopathy
Interventions: PROCEDURE: Lymph Node Needle Tissue Collections
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Epidural Stimulation and Resistance Training After SCI
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Exoskeletal assisted walking|DEVICE: Epidural Stimulation|PROCEDURE: Resistance Training|DEVICE: delayed-ES|PROCEDURE: no-Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: BIOLOGICAL: Autologous CD34+ HSC cells transduced with the lentiviral vector containing a shRNA targeting BCL11a
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Boost in Treating Patients With Low Blood Cells After Donor Stem Cell Transplant
Status: WITHDRAWN
Conditions: Anemia|Hematopoietic/Lymphoid Cancer|Lymphopenia|Neutropenia|Thrombocytopenia
Interventions: BIOLOGICAL: Allogeneic hematopoietic stem cell transplantation|BIOLOGICAL: Peripheral blood stem cell transplantation|PROCEDURE: Management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: tetracycline hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Graft Versus Host Disease|Lymphoma
Interventions: DRUG: carmustine|DRUG: melphalan|DRUG: etoposide|DRUG: cytarabine|DRUG: tacrolimus|DRUG: methotrexate|DRUG: sargramostim|PROCEDURE: transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mass Balance and Absolute Bioavailability of GLPG3667
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG3667 capsule|DRUG: [14C]-GLPG3667 solution for infusion|DRUG: [14C]-GLPG3667 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Evaluating 3-Level OLIF Spine Fusion
Status: WITHDRAWN
Conditions: Spondylolisthesis|Retrolisthesis|Degenerative Disc Disease
Interventions: OTHER: ViBone®|OTHER: Demineralized Bone Matrix|OTHER: Bone Morphogenetic Protein
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis From Colorectal, Appendiceal, Small Bowel, Gastric, Cholangiocarcinoma, Breast, Ovarian, or Other Gynecologic Primary Cancer
Status: RECRUITING
Conditions: Gynecologic Cancer|Gynecologic Neoplasms|Peritoneal Carcinomatosis|Peritoneal Neoplasms|Ovarian Cancer|Ovarian Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Appendiceal Cancer|Appendiceal Neoplasms
Interventions: DRUG: Paclitaxel|DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AFP Specific T Cell Receptor Transduced T Cells Injection(C-TCR055) in Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: AFP Specific T Cell Receptor T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies
Status: RECRUITING
Conditions: Myelodysplastic Syndrome|Acute Myeloid Leukemia
Interventions: DRUG: SEA-CD70|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate Hypertension
Status: COMPLETED
Conditions: Essential Hypertension ( Mild to Moderate)
Interventions: DRUG: Aliskiren|DRUG: Hydrochlorothiazide|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) and Tolerability of AVP-786 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AVP-786 Dose 1|DRUG: AVP-786 Dose 2|DRUG: AVP-786 Dose 1/Q Dose 1|DRUG: AVP-786 Dose 1/Q Dose 2|DRUG: AVP-786 Dose 2/Q Dose 2|DRUG: AVP-923
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Significance of Contralateral Central Lymph Node Dissection in Unilateral cN0 Differentiated Thyroid Carcinoma.
Status: UNKNOWN
Conditions: Lymph Node Dissection|Lymph Node Metastases|Differentiated Thyroid Carcinoma
Interventions: PROCEDURE: contralateral central lymph node dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK
Status: COMPLETED
Conditions: Neurotrophic Keratitis
Interventions: DRUG: rhNGF 20µg/ml|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban for the Treatment of Symptomatic Isolated Distal Deep Vein Thrombosis
Status: UNKNOWN
Conditions: Deep Vein Thrombosis
Interventions: DRUG: rivaroxaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study To Test How Filgrastim Hospira Works In The Body Of Healthy Study Subjects When Given By Subcutaneous Injection (Shot) Compared To An Already U.S.-Approved Drug Neupogen® (Amgen)
Status: COMPLETED
Conditions: Neutropenia (Low White Blood Cell Count)
Interventions: BIOLOGICAL: Filgrastim Hospira (US)|BIOLOGICAL: US-approved Neupogen®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reconstruction of Deficient Interdental Papilla Using Stem Cells vs Physiological Saline
Status: ENROLLING_BY_INVITATION
Conditions: Gingival Recession, Localized
Interventions: BIOLOGICAL: Umbilical cord-mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Nasal Spray.
Status: TERMINATED
Conditions: Epilepsy
Interventions: DRUG: diazepam nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of GraduCheck® to Enable Nurses to Achieve Ideal Sub-Bandage Pressures
Status: UNKNOWN
Conditions: Compression Bandage
Interventions: DEVICE: Compression bandaging without reference to GraduCheck pressure measurements|DEVICE: Compression bandaging using GraduCheck pressure measurements to monitor compression pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparative Therapeutic Efficacy and Safety of Different Antiviral and Anti Inflammatory Drugs in COVID-19 Patients.
Status: UNKNOWN
Conditions: Covid19|Pneumonia
Interventions: DRUG: Remdesivir|DRUG: Hydroxychloroquine|DRUG: Tocilizumab|DRUG: Lopinavir/ Ritonavir|DRUG: Ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 2 Doses of HRV Vaccine Given Concomitantly With Routine EPI Vaccinations Including OPV in Healthy Infants
Status: COMPLETED
Conditions: Infections, Rotavirus
Interventions: BIOLOGICAL: 2-dose oral live attenuated G1P[8] human rotavirus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of Stiripentol (Diacomit) as Monotherapy for the Treatment of Primary Hyperoxaluria
Status: COMPLETED
Conditions: Primary Hyperoxaluria
Interventions: DRUG: stiripentol (Diacomit)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT