pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Tolerability of Single and Multiple Doses of LB-102 in Healthy Adults
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: LB-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma
Status: RECRUITING
Conditions: Thymic Epithelial Tumor|Recurrent Thymoma|Thymic Cancer
Interventions: DRUG: M7824
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preemptive Endoluminal Negative Pressure in Minimally Invasive Transthoracic Esophagectomy
Status: UNKNOWN
Conditions: Esophageal Cancer|Surgery--Complications|Leak, Anastomotic
Interventions: DEVICE: Eso-SPONGE® device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ambulatory Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: PROCEDURE: Ambulatory Laparoscopic Sleeve Gastrectomy|PROCEDURE: Conventional Laparoscopic Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 6-Week Proof-of-Concept Study of Travoprost/Brinzolamide Ophthalmic Suspension in Subjects With Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Dose Level A / Brinzolamide 1% ophthalmic suspension|DRUG: Dose Level B / Brinzolamide 1% ophthalmic suspension|DRUG: Dose Level C / Brinzolamide 1% ophthalmic suspension|DRUG: Brinzolamide 1% ophthalmic suspension AZOPT®|DRUG: Travoprost 0.004% ophthalmic solution TRAVATAN Z®|DRUG: Travoprost solution vehicle|DRUG: Brinzolamide suspension vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Continuous Positive Airway Pressure on Chronotype, Dietary Intake, and Cardiovascular Risk Markers
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea of Adult
Interventions: DEVICE: Device: active CPAP|DEVICE: Device: sham-CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PK and PD Study of IDN-6556 in Subjects With Hepatic Impairment and Matched Healthy Volunteers
Status: COMPLETED
Conditions: Hepatic Impairment|Liver Diseases|Digestive System Diseases
Interventions: DRUG: IDN-6556
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding Study of SC411 in Children With Sickle Cell Disease
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: DRUG: Docosahexaenoic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Protein on Calcium Absorption and Gastric Acid Production
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: esomeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Burdock and Blood Pressure in African-American Women
Status: UNKNOWN
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Burdock|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study on the Safety and Efficacy of a Single Intra-articular Administration of JTA-004 in Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Symptomatic Osteoarthritis of the Knee
Interventions: DRUG: JTA-004|DEVICE: Hylan G-F 20|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure
Status: COMPLETED
Conditions: Acute on Chronic Hepatic Failure
Interventions: DRUG: Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Sibutramine|DRUG: Orlistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Personalizing Intervention to Reduce Clinical Inertia in the Treatment of Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Audit and Feedback|BEHAVIORAL: Pharmacist E-Detailing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of a Single Oral Dose of KETone Ester ON Exercise Performance in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction|Heart Failure
Interventions: DIETARY_SUPPLEMENT: Ketone ester drink (DeltaG®, 500 mg/kg body weight)|DIETARY_SUPPLEMENT: Taste-matched, isovolumic placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caries Inhibitory Effect of Nano Silver and Tri Calcium Phosphate Varnishes Among Visually Impaired Children
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Nano silver fluoride varnish and tri calcium phosphate varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tidal Neonatal NO, Vitamins A and D, and Infant Lung Disease - The AD-ON Study
Status: COMPLETED
Conditions: Term Delivery With Preterm Labor, Third Trimester|Term Delivery With Preterm Labor, Unspecified Trimester|Bronchopulmonary Dysplasia
Interventions: PROCEDURE: measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Human Melanocytes After the Use of PRP Versus Fractional CO2 Laser in Vitiligo
Status: UNKNOWN
Conditions: Vitiligo
Interventions: PROCEDURE: Platelet rich plasma|PROCEDURE: Fractional CO2 laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Venetoclax (ABT-199) and Dexamethasone for Relapsed or Refractory Systemic AL Amyloidosis
Status: TERMINATED
Conditions: AL Amyloidosis
Interventions: DRUG: Venetoclax|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of DUR-928 in Patients With Alcoholic Hepatitis
Status: COMPLETED
Conditions: Alcoholic Hepatitis
Interventions: DRUG: DUR-928 30 mg|DRUG: DUR-928 90 mg|DRUG: DUR-928 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Doxorubicin and Bortezomib in Patients With Incurable Adenoid Cystic Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Adenoid Cystic Carcinoma
Interventions: DRUG: doxorubicin and bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Nemvaleukin Alfa in Combination With Pembrolizumab in Patients With Platinum-Resistant Epithelial Ovarian Cancer (ARTISTRY-7)
Status: ACTIVE_NOT_RECRUITING
Conditions: Platinum-resistant Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Interventions: BIOLOGICAL: Nemvaleukin and Pembrolizumab Combination|BIOLOGICAL: Pembrolizumab|BIOLOGICAL: Nemvaleukin|DRUG: Pegylated Liposomal Doxorubicin (PLD)|DRUG: Paclitaxel|DRUG: Topotecan|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug Drug Interaciton Study of Imrecoxib and Warfarin in Healthy Volunteers
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DRUG: Imrecoxib|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toric Contact Lens Digital Performance and Comfort Study
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Precision1 for Astigmatism|DEVICE: Precision1 Sphere
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Follow-Up to the DEVO Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers
Status: COMPLETED
Conditions: Venous Leg Ulcer
Interventions: DEVICE: Dermagraft|DEVICE: Profore
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Children With Primitive Neuroectodermal Tumors
Status: COMPLETED
Conditions: Childhood CNS Primitive Neuroectodermal Tumor
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Engagement for Learning to Effectively Control Type 2 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Lifestyle|Hyperglycemia|Physical Inactivity
Interventions: BEHAVIORAL: Focused App Prompt|BEHAVIORAL: No App Prompt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Adult Autologous Stem Cells in Treating People 2 to 3 Weeks After Having a Heart Attack (The Late TIME Study)
Status: COMPLETED
Conditions: Left Ventricular Dysfunction
Interventions: BIOLOGICAL: Adult stem cells|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment
Status: COMPLETED
Conditions: Recurrent Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: Ixazomib Citrate|DRUG: Pevonedistat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ?
Status: COMPLETED
Conditions: Anal Incontinence
Interventions: DRUG: Metronidazole|DRUG: CArbosylane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients
Status: TERMINATED
Conditions: Rib Fractures
Interventions: DRUG: Ropivacaine|DRUG: Normal Saline Flush, 0.9% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Chemo-immunotherapy as First Line Treatment in Adult Patients With Peripheral T- Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, T-Cell, Peripheral
Interventions: PROCEDURE: Clin A. CHOP-CAMPATH (Chemo-immunotherapy) + SCT|DRUG: Clin B (CHOP- CAMPATH) Chemo-immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia in Total Hip Arthroplasty by Quadratus Lumborum Block
Status: COMPLETED
Conditions: Total Hip Replacement Surgery
Interventions: PROCEDURE: Quadratus Lumborum Block|PROCEDURE: femoral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Adrenocorticotropin Injection With Weekly Interferon Beta in Patients With Relapsing Remitting Multiple Sclerosis (MS)
Status: WITHDRAWN
Conditions: Multiple Sclerosis
Interventions: DRUG: repository corticotropin injection|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition
Status: COMPLETED
Conditions: Barrett's Esophagus|Gastroesophageal Reflux Disease
Interventions: OTHER: Cessation of Acid Suppressing Medications
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Thorough QT Study of TR-701free Acid (FA) in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: TR-701 FA 1200 mg|DRUG: Moxifloxacin 400 mg|DRUG: TR-701 FA 200 mg plus Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A PHASE IIB, RANDOMIZED, ASSESSOR-MASKED, MULTICENTER CLINICAL TRIAL TO ASSESS THE SAFETY AND EFFICACY OF SUBRETINAL IMPLANTATION OF THE CPCB-RPE1 IMPLANT IN SUBJECTS WITH ADVANCED, DRY AMD (GEOGRAPHIC ATROPHY)
Status: NOT_YET_RECRUITING
Conditions: Dry Age-related Macular Degeneration|Geographic Atrophy
Interventions: DEVICE: Surgical implantation of the CPCB-RPE1 implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PhaseII,Open-label,Pilot Study Evaluating the Safety+Efficacy of Certican ® in the Prevention of Chronic Graft-versus-host Disease+Late Pulmonary Complications After Allogeneic Hematopoietic Cell Transplantation Blood
Status: COMPLETED
Conditions: Condition After Allogenic Peripheral Stem Cell Transplantation (SCT)
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of SSGJ-707 in Metastatic Colorectal Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: SSGJ-707|DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Calcium Folinate|DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis
Status: UNKNOWN
Conditions: Halitosis
Interventions: OTHER: Tongue Scraping|RADIATION: aPDT|RADIATION: Tongue scraper and aPDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Phacoaspiration and Angle Surgery Versus Phacoaspiration in Pediatric Cataract
Status: UNKNOWN
Conditions: Pediatric Glaucoma
Interventions: PROCEDURE: Group A :combined phacoaspiration and angle surgery|PROCEDURE: Group B : phacoaspiration only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of a High Protein Diet on Microbiota, Gastrointestinal Function and Wellness in Older Women
Status: COMPLETED
Conditions: Aging
Interventions: DIETARY_SUPPLEMENT: Probiotic capsule and Fiber Sachet|DIETARY_SUPPLEMENT: Probiotic capsule and Placebo sachet|DIETARY_SUPPLEMENT: Placebo capsule and Fiber Sachet|DIETARY_SUPPLEMENT: Placebo capsule and Placebo sachet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Virtual Reality and Buzzy Application on Pain, Fear and Anxiety During Prick Test in Children
Status: NOT_YET_RECRUITING
Conditions: Pain|Fear|Anxiety|Children, Only|Virtual Reality
Interventions: BEHAVIORAL: Virtual Reality Group|BEHAVIORAL: Buzzy Application Group|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ODM-201 vs Androgen Deprivation Therapy in Hormone naïve Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: ODM-201|DRUG: ADT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Assessment in Children Undergoing Spine Surgery
Status: COMPLETED
Conditions: Adolescent Idiopathic Scoliosis|Cerebral Palsy
Interventions: BEHAVIORAL: Pain assessment for verbal patients|BEHAVIORAL: Pain assessment for non-verbal patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirena Intrauterine System Timing of Insertion: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Postpartum Period
Interventions: DEVICE: Post-Placenta Mirena Insertion|DEVICE: Interval Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High-intensity Interval Training in Patients With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: High-intensity interval training|BEHAVIORAL: Moderate-intensity continuous training|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VRx@Home: Study to Evaluate VR-therapy for PwD Living at Home
Status: COMPLETED
Conditions: Dementia
Interventions: DEVICE: HMD: Immersive VR|DEVICE: Tablet: Non-immersive VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of 50% Nitrous Oxide/50% Oxygen Gas Premix in Chronic Leg Ulcer Debridement
Status: COMPLETED
Conditions: Chronic Leg Ulcer
Interventions: PROCEDURE: N2O/O2 analgesia|PROCEDURE: Lidocaine/Prilocaine analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Study Of CD07743 for the Improvement of Lateral Canthal Lines (CROW'S FEET)
Status: COMPLETED
Conditions: Canthal Lines
Interventions: DRUG: Botulinum Toxin Type A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ⅰa Clinical Trial of a Pneumococcal Vaccine
Status: COMPLETED
Conditions: Pneumonia|Respiratory Tract Diseases|Respiratory Tract Infections
Interventions: BIOLOGICAL: Protein based pneumococcal vaccine(Low dose)|BIOLOGICAL: Protein based pneumococcal vaccine placebo(Low dose)|BIOLOGICAL: Protein based pneumococcal vaccine(Middle dose)|BIOLOGICAL: Protein based pneumococcal vaccine placebo(Middle dose)|BIOLOGICAL: Protein based pneumococcal vaccine(High dose)|BIOLOGICAL: Protein based pneumococcal vaccine placebo(High dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Multiple-Dose LEA29Y vs CTLAG4Ig vs Placebo in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Belatacept|DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Novel Indirect Laryngoscopes to the Macintosh Laryngoscope in Patients With Cervical Spine Immobilization.
Status: COMPLETED
Conditions: Immobilization
Interventions: DEVICE: intubate with the macintosh laryngoscope|DEVICE: intubate with the C-MAC laryngoscope|DEVICE: intubate with the Airtraq device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CARDIOLOGIST Trial: Artificial Intelligence Enabled Electrocardiogram for Atrial Fibrillation Detection
Status: COMPLETED
Conditions: Atrial Fibrillation New Onset
Interventions: OTHER: AI-enabled ECG-based Screening Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: SM04690|OTHER: Placebo|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SAFETY-A for Promoting Equity in Suicide Prevention Outcomes in Schools
Status: RECRUITING
Conditions: Suicidal Ideation
Interventions: BEHAVIORAL: Safe Alternatives for Teens and Youth-Acute for Schools (SAFETY-A for Schools)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cancer Related Cognitive Impairment After Chemotherapy: Evaluation of Potential Therapeutic Interventions
Status: UNKNOWN
Conditions: Cognitive Impairment
Interventions: BEHAVIORAL: Mindfulness|BEHAVIORAL: Physical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Night Eye Mask on Post-operative Pain in Cardiac Surgery Patients
Status: COMPLETED
Conditions: Sleep Deprivation|Postoperative Pain
Interventions: OTHER: Flight Eye-masks; Dreaming, Zhuji City, Zhejiang, China
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "As Required" Oral Sildenafil in Raynaud's Phenomenon
Status: COMPLETED
Conditions: Raynaud's Phenomenon
Interventions: DRUG: Sildenafil 40 mg|DRUG: Sildenafil 80 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Lapatinib|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembro+Chemo in Brain Mets
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Lung Cancer Metastatic|Brain Cancer|Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Nab paclitaxel|DRUG: Paclitaxel|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Pts w/Chronic Myeloid Leukemia
Status: RECRUITING
Conditions: Chronic Myeloid Leukemia|Chronic Phase Chronic Myelogenous Leukemia
Interventions: OTHER: Interview
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Patupilone on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Advanced Malignancies
Status: TERMINATED
Conditions: Advanced Malignancies
Interventions: DRUG: Patupilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics (PK), and Efficacy of TAK-671 for the Treatment of Coronavirus Disease (COVID) 2019 in Adults
Status: WITHDRAWN
Conditions: Coronavirus Disease
Interventions: DRUG: TAK-671|DRUG: TAK-671 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Equitable and Effective (E-3) Post Traumatic Stress Disorder (PTSD) Disability Assessment
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: CAPS/WHODAS|BEHAVIORAL: Nonstructured Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparison of Two Target Mean Arterial Pressures in the Resuscitation of Hypotensive Trauma Patients
Status: UNKNOWN
Conditions: Hemorrhagic Shock|Trauma|Wounds, Penetrating|Shock, Traumatic|Multiple Trauma
Interventions: PROCEDURE: Intraoperative Hypotensive Resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis
Status: COMPLETED
Conditions: Myocarditis
Interventions: DRUG: DOTATOC-68Ga PET initial|DRUG: DOTATOC-68Ga PET at 6 months|BIOLOGICAL: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of Pronator Teres Release on Treatment of Median Nerve Compression Neuropathy
Status: UNKNOWN
Conditions: Median Nerve Compression
Interventions: PROCEDURE: Pronator Teres Release|PROCEDURE: dual compression release|PROCEDURE: dual compression release|PROCEDURE: median nerve release only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy on TMJ Disorders After Head and Neck Cancer.
Status: RECRUITING
Conditions: Temporomandibular Joint Disorders
Interventions: DEVICE: High intensity laser|OTHER: traditional physical therapy exercise program|DEVICE: placebo High intensity laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.
Status: COMPLETED
Conditions: Osteoporosis|Osteopenia
Interventions: DRUG: Alendronate|DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HAT for the Treatment of Sepsis Associated With NASTI
Status: TERMINATED
Conditions: Necrotizing Soft Tissue Infection|Sepsis
Interventions: DRUG: HAT|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Increasing Auditory Cueing Affect Gait Parameters in Children With Cerebral Palsy During a Functional Task?
Status: COMPLETED
Conditions: Cerebral Palsy|Children
Interventions: DEVICE: Auditory Cueing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Responses During Induction: Comparison of Marsh and Schnider Pharmacokinetic Models
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Marsh Plasma TCI with high initial target|PROCEDURE: Schnider Plasma TCI with high initial target
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Early Postprocedural Susceptibility-Weighted Imaging and Vessel-Wall Imaging For Prediction of Complications After Flow-Diversion Treatment
Status: RECRUITING
Conditions: Early Susceptibility-Weighted Imaging and Vessel-Wall Imaging Findings After Flow-Diversion Treatment of Intracranial Aneurysms
Interventions: DIAGNOSTIC_TEST: Pre-procedural, early and late post-procedural susceptibility weighted imaging and vessel wall imaging with a 3T Magnetic Resonance Imaging Device|PROCEDURE: Aneurysm Treatment with Flow-Diversion Therapy|PROCEDURE: Aneurysm Treatment with Metalic Bare Stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ankura™ AAA, Cuff and AUI Stent Graft System Post-Market Clinical Follow-Up
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Ankura™ AAA Stent Graft System; Ankura™ Cuff Stent Graft System; Ankura™ AUI Stent Graft System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AP-011 Study to Evaluate the Safety of a Single Intra-articular Injection of Ampion™ for Arthritis of the Basal Thumb Joint
Status: COMPLETED
Conditions: Osteoarthritis of the Hand
Interventions: BIOLOGICAL: AMPION™|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection
Status: TERMINATED
Conditions: HIV Infections|Neurologic Disorders
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Daytime Bright Light, Circadian Abnormalities, and Delirium in Medical ICU Patients
Status: COMPLETED
Conditions: Circadian Rhythm Disorders
Interventions: DEVICE: Daytime Bright Light|DEVICE: Usual Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Esomeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Docosahexaenoic Acid (DHA) Effects on Cognitive Function, Craving and Psychosocial Factors in Heavy Cigarette Smokers
Status: COMPLETED
Conditions: HEAVY TOBACCO SMOKERS
Interventions: DIETARY_SUPPLEMENT: DHA|DIETARY_SUPPLEMENT: Oral ingestion of 5 placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combined FDG PET/CT Imaging in Response Evaluation After Radiochemotherapy in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
Status: COMPLETED
Conditions: Locally Advanced Squamous Cell Carcinoma of the Head and Neck Region
Interventions: OTHER: Integrated FDG PET/CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hydrops: Diagnosing & Redefining Outcomes With Precision Study
Status: ENROLLING_BY_INVITATION
Conditions: Hydrops Fetalis|Birth Defect|Fetal Anomaly
Interventions: DIAGNOSTIC_TEST: Exome sequencing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Pharmacokinetics Study in Healthy Japanese Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ABX464|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Postprandial Glycemic and Insulinemic Response of ALLSWEET When Taken Alone or When Added to Sucrose
Status: COMPLETED
Conditions: Blood Sugar
Interventions: OTHER: ALLSWEET®|OTHER: ALLSWEET® and sucrose|OTHER: Sucrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open-Label Study to Evaluate the Response to Adalimumab in Patients With Active Ankylosing Spondylitis Who Have Failed Standard Therapy or TNF-Alpha Inhibitors (RHAPSODY)
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: adalimumab (Humira)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cardiorespiratory Exercise & Chinese Medicine for Rehabilitation of Discharged Coronavirus Disease (COVID-19) Patients
Status: UNKNOWN
Conditions: Coronavirus Disease (COVID-19)
Interventions: OTHER: Cardiorespiratory Exercise|OTHER: Modified Bai He Gu Jin Tang
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Versus Sham for Radiotherapy-Induced Emesis
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: PROCEDURE: Acupuncture|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Repeat Administration of Eslicarbazepine Acetate on the Pharmacokinetics of a Combined Oral Contraceptive
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: eslicarbazepine acetate and Microginon®|DRUG: Microginon®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of 3 Contact Lens Materials With 3 Solution Types
Status: COMPLETED
Conditions: Visual Acuity, Slit Lamp Biomicroscopy (Corneal Staining Assessment)
Interventions: DEVICE: Opti-Free : RevitaLens / Clear Care : RevitaLens|DEVICE: Opti-Free : RevitaLens / RevitaLens : Clear Care|DEVICE: Clear Care : RevitaLens/ Opti-Free : RevitaLens|DEVICE: Clear Care : RevitaLens / RevitaLens : Opti-Free|DEVICE: RevitaLens : Clear Care/ Opti-Free : RevitaLens|DEVICE: RevitaLens : Clear Care / RevitaLens : Opti-Free|DEVICE: RevitaLens : Opti-Free / Clear Care : RevitaLens|DEVICE: RevitaLens : Opit-Free / RevitaLens : Clear Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2)
Status: NOT_YET_RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: ShA9 Topical Gel|DRUG: Hydrocortisone Ointment|DRUG: Clobetasol Ointment|DRUG: Fluocinonide Ointment|DRUG: Placebo (Vehicle) Topical Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement in Clinical Outcomes in Heart Failure Patients With ICDs That Practice Meditation
Status: COMPLETED
Conditions: Congestive Heart Failure|Cardiac Resynchronization Therapy
Interventions: BEHAVIORAL: Vipassana Meditation practice and instruction|OTHER: Standard Medical Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens
Status: COMPLETED
Conditions: Itch
Interventions: DRUG: Emla 1 hour|DRUG: EMLA 3 hours|OTHER: Vehicle cream for 1 hour|OTHER: Vehicle cream for 3 hours|OTHER: Cowhage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Protocol for RCT of Posturing in Phacovitrectomy for Full Thickness Macular Hole (FTMH)
Status: COMPLETED
Conditions: Full Thickness Macular Hole
Interventions: BEHAVIORAL: Face down posture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Dose Strengths of Selexipag in Healthy Adults
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Selexipag (adult formulation)|DRUG: Selexipag (pediatric formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of Toric Soft Contact Lenses Containing a Chromophore to Block High-Energy Visible Light
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: soft contact lens in senofilcon A (C3) with HEVL-blocking chromophore|DEVICE: ACUVUE OASYS 1-Day for Astigmatism
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed Disodium and Carboplatin or Cisplatin With or Without Erlotinib Hydrochloride in Treating Patient With Stage IV Non-Small Cell Lung Cancer Resistant to First-Line Therapy With Erlotinib Hydrochloride or Gefitinib
Status: WITHDRAWN
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: DRUG: pemetrexed disodium|DRUG: carboplatin|DRUG: cisplatin|DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Lower Limb Functionality, Foot Joint Position Sensation and Balance in Haemiplegic Patients
Status: COMPLETED
Conditions: Being Between 40-80 Years Old|Being Diagnosed With Haemiplegia|Getting 20 Points or More in the Mini Mental Test|Volunteering to Participate in the Study|Level 2 or Above According to Functional Ambulation Classification
Interventions: OTHER: Humac Norm İsokinetic Machine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anesthetics in Rhytidoplasty - A Comparison Study
Status: COMPLETED
Conditions: Rhytidoplasty
Interventions: DRUG: clonidine|DRUG: glycopyrrolate|DRUG: propofol|DRUG: ketamine|DRUG: marcaine|DRUG: scopolamine|DRUG: midazolam|DEVICE: ondansetron|DRUG: metoclopramide|DRUG: glycopyrrolate|DRUG: lidocaine|DRUG: famotidine|DRUG: desflurane|DRUG: sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effect of Intravenous Dextrose on PONV in Patients Undergoing Gynecological Laparoscopy
Status: RECRUITING
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: 5% glucose|OTHER: lactated ringers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Children With Hemiparesis Arm and Hand Movement Project (CHAMP Study)
Status: COMPLETED
Conditions: Hemiparesis|Cerebral Palsy|Brain Injury
Interventions: BEHAVIORAL: Variations in Pediatric Constraint-Induced Movement Therapy (P-CIMT) versus usual and customary rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of NTRA-2112 on Intestinal Malabsorption in Preterm Infants
Status: UNKNOWN
Conditions: Premature Birth of Newborn|Intestinal Malabsorption
Interventions: DRUG: NTRA-2112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventive Effect of Boron-based Gel on Radiation Dermatitis
Status: COMPLETED
Conditions: Radiodermatitis
Interventions: DRUG: Boron-based Gel (Fibore)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: VX-950-C211 - A Dosing Regimen Study (Twice Daily Versus Every 8 Hours) of Telaprevir in Treatment-naïve Participants With Genotype 1 Chronic Hepatitis C Virus Infection
Status: COMPLETED
Conditions: Genotype 1 Chronic Hepatitis C|Treatment Naive
Interventions: DRUG: Ribavirin|DRUG: Telaprevir|DRUG: Pegylated interferon alfa-2a|DRUG: Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms
Status: RECRUITING
Conditions: Polycythemia Vera|Essential Thrombocythemia|Prefibrotic/Early Primary Myelofibrosis|JAK2 V617F|High-risk Patients
Interventions: DRUG: Direct Oral Anticoagulants|DRUG: Low-dose aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acthar Gel for Multiple Sclerosis That Keeps Getting Better and Worse (RRMS)
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Acthar Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Exercise Endurance Study to Evaluate the Effects of Treatment of Chronic Obstructive Pulmonary Disease (COPD) Patients With a Dual Bronchodilator: GSK573719/GW642444.Study B
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK573719/GW642444 125/25|DRUG: GSK573719/GW642444 62.5/25|DRUG: GSK573719 125|DRUG: GSK573719 62.5|DRUG: GW642444 25|DEVICE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes AutoimmunitY Withdrawn in Established Patients (DAY)
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: TOL-3021|OTHER: TOL-3021 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine
Status: COMPLETED
Conditions: Other Surgical Procedures
Interventions: DRUG: midazolam|DRUG: prilocaine 1%|DRUG: prilocaine 1%|DRUG: prilocaine 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study Of An Investigational Regimen Including FDA Approved HIV Drugs In HIV-Infected Pediatric Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: GW433908|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Pharmacokinetics and Pharmacodynamics of Romiplostim in Patients With Immune Thrombocytopenia (ITP)
Status: COMPLETED
Conditions: Immune Thrombocytopenia (ITP)
Interventions: DRUG: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells Therapy for Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: Mesenchymal progenitor cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Higher Positive End Expiratory Pressure on Patient-Ventilator Asynchrony
Status: UNKNOWN
Conditions: Critical Illness
Interventions: OTHER: Higher PEEP setting|OTHER: Lower PEEP setting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.
Status: COMPLETED
Conditions: Furcation Defects|Periodontal Disease
Interventions: DEVICE: Anorganic Bovine Bone|DEVICE: Enamel Matrix Derivative
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Adult Fibrosarcoma|Adult Leiomyosarcoma|Adult Liposarcoma|Adult Malignant Fibrous Histiocytoma|Adult Rhabdomyosarcoma|Dermatofibrosarcoma Protuberans|Endometrial Stromal Sarcoma|Recurrent Adult Soft Tissue Sarcoma|Recurrent Uterine Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage III Uterine Sarcoma|Stage IV Adult Soft Tissue Sarcoma|Stage IV Uterine Sarcoma|Uterine Carcinosarcoma|Uterine Leiomyosarcoma
Interventions: DRUG: saracatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT