pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Glycaemic Index Determination in Oral Nutrition Supplements
Status: RECRUITING
Conditions: Glucose Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 1|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 2|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 3|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 4|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 5|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 6|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 7|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 8|DIETARY_SUPPLEMENT: Complete Oral Nutrition Supplement 9|DIETARY_SUPPLEMENT: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 16-week Efficacy and 3-year Safety, Tolerability and Efficacy of Secukinumab in Active Ankylosing Spondylitis Patients
Status: COMPLETED
Conditions: Spondylitis, Ankylosing
Interventions: DRUG: Secukinumab|DRUG: Placebo secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Safety and Pharmacokinetic Study of K305
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Tetracaine HCl 3% and Oxymetazoline HCl 0.05%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.
Status: RECRUITING
Conditions: Infertility
Interventions: DRUG: Progesterone-IBSA Injectable Solution|DRUG: Progesterone Vaginal Gel with Applicator|DRUG: Placebo Vaginal gel with applicator|DRUG: Placebo injectable solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immune Response to a Combination HIV Vaccine Regimen in HIV Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Clade B gag DNA/PLG and env DNA/PLG Microparticles|BIOLOGICAL: Clade B Recombinant, Oligomeric gp140/MF59 Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Comparison of Effectiveness of Ear Syringing With or Without Pre-Ear Oil Application , Non-randomized Control Trial.
Status: UNKNOWN
Conditions: Cerumen Impaction of Both Ears
Interventions: PROCEDURE: ear wax syringing without pre ear oil treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise
Status: COMPLETED
Conditions: Ocular Physiology|Regional Blood Flow
Interventions: DRUG: Clonidin|DRUG: Brimonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Low-Dose Methotrexate for Reducing Inflammation in HIV-Infected Adults on ARV Medications
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: LDMTX|DRUG: Placebo|DIETARY_SUPPLEMENT: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Marginal Bone Loss After Immediate Implant Placement in Esthetic Zone Without Xenograft.
Status: UNKNOWN
Conditions: Bone Loss
Interventions: PROCEDURE: xenograft placement .
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Vitamin D Supplementation on Dental Implant Osseointegration: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Osseointegration Failure of Dental Implant
Interventions: DRUG: Vitamin D3|DRUG: Vitamin E 400
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy and Safety of Meptin® Swinghaler and Berotec N® Metered Aerosol in Mild to Moderate Stable Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Meptin swinghaler|DRUG: Berotec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing to Improve Work Outcomes in Schizophrenia
Status: COMPLETED
Conditions: Schizoaffective Disorder|Schizophrenia
Interventions: BEHAVIORAL: IPS|BEHAVIORAL: IE|BEHAVIORAL: VOMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Unintentional Leakage When Using Nasal CPAP - Study A
Status: NOT_YET_RECRUITING
Conditions: Continuous Positive Airway Pressure|Adverse Effect|Obstructive Sleep Apnea
Interventions: DEVICE: CPAP (fixed mode)|DEVICE: APAP (automatic mode)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Cervical Stabilization Exercises on the Cervical Proprioception in Patients With Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Chronic Neck Pain
Interventions: BEHAVIORAL: Cervical Stabilization Exercise|BEHAVIORAL: Cervical Standard Exercise Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous Lactate on Brain Lactate Concentrations During Hypoglycemia
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus With Hypoglycemia
Interventions: DRUG: SodiumChloride|DRUG: Sodium Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations.
Status: UNKNOWN
Conditions: Iron Deficiency|Anemia
Interventions: DRUG: Ferrous gluconate and iron polysaccharide complex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemostatic Powder Following Injection Therapy Versus Conventional Dual Therapy for Endoscopic Hemostasis for Non-variceal Upper Gastrointestinal Bleeding
Status: COMPLETED
Conditions: Upper Gastrointestinal Bleeding
Interventions: DEVICE: Endo-Clot|DEVICE: hemoclip or electrical coagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accurate Point of Care Liver Disease Diagnostics
Status: RECRUITING
Conditions: NAFLD|Nonalcoholic Fatty Liver
Interventions: DIAGNOSTIC_TEST: Liverscope® exam|DIAGNOSTIC_TEST: MR exam|DIAGNOSTIC_TEST: FibroScan® exam (optional)|OTHER: Blood draw|OTHER: Body measurements|OTHER: Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Spectral Domain Optical Coherence Tomography Analysis for Glaucoma
Status: COMPLETED
Conditions: GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Interventions: DEVICE: RS-3000 OCT measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: The EpiGASTRIC/EDGAR Project: New Strategies for the Early Detection and Prevention of Gastric Cancer
Status: RECRUITING
Conditions: Gastric Neoplasms|Gastric Cancer|Gastric Lesion
Interventions: OTHER: Identification of risk factors|OTHER: Characterization of premalignant gastric lesions|OTHER: Identification of biomarkers|OTHER: Identification of gastric cancer hereditary predisposition
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Red Ginseng on Gastrointestinal Symptoms and Microbiota After Surgery for Gastrointestinal Cancer
Status: COMPLETED
Conditions: Stomach Cancer|Pancreatobiliary Cancer|Colorectal Cancer
Interventions: PROCEDURE: Arm I (Red ginseng)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Correlation Between Fasicitis Plantaris and Hallux Rigidus
Status: WITHDRAWN
Conditions: Hallux Rigidus|Fasicitis Plantaris
Interventions: PROCEDURE: Clinical examination and radiological evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 2 Dose Selection Trial of Candesartan Cilexetil and Amlodipine Besylate to Treat Essential Hypertension
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: Amlodipine 5mg|DRUG: Amlodipine 10mg|DRUG: Candesartan Cilexetil 8mg|DRUG: Candesartan cilexetil 16mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Paracervical Block on Post Operative Pain in Laparoscopic Gynecologic Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Paracervical Block|Laparoscopic Gynecologic Surgery
Interventions: DRUG: Bupivacaine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy Between Helicobacter Pylori Eradication Therapy and Motilitone in Functional Dyspepsia
Status: UNKNOWN
Conditions: Functional Dyspepsia
Interventions: DRUG: Motilitone®|DRUG: A-Cilin®, Clari® and Pantoline®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Folinic Acid Intervention for Autism Spectrum Disorders
Status: TERMINATED
Conditions: Autism Spectrum Disorder|Autistic Disorder|Autism|Asperger's Syndrome|Pervasive Development Disorders
Interventions: DRUG: Folinic Acid and placebo|DRUG: Folinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature
Status: COMPLETED
Conditions: Idiopathic Short Stature
Interventions: DRUG: Aromatase Inhibitor|DRUG: Growth Hormone|DRUG: Aromatase Inhibitor and Growth Hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Crossword and Word Search Puzzles on Nursing Students' Parenteral Medication Administration Knowledge
Status: COMPLETED
Conditions: Nursing Education|Medicatioon Administration Knowledge|Puzzle
Interventions: OTHER: Crossword and word search puzzles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Irreversible Electroporation for Inoperable Hepatic and Pancreatic Malignancy
Status: TERMINATED
Conditions: Hepatic Malignant Tumors|Pancreatic Cancer
Interventions: PROCEDURE: IRE treatment|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Ganglioneuroblastoma|Neuroblastoma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|DRUG: Busulfan|DRUG: Carboplatin|DRUG: Cisplatin|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Dexrazoxane Hydrochloride|BIOLOGICAL: Dinutuximab|DRUG: Doxorubicin Hydrochloride|PROCEDURE: Echocardiography|DRUG: Etoposide Phosphate|RADIATION: External Beam Radiation Therapy|RADIATION: Iobenguane I-123|RADIATION: Iobenguane I-131|DRUG: Isotretinoin|DRUG: Lorlatinib|PROCEDURE: Magnetic Resonance Imaging|DRUG: Melphalan Hydrochloride|PROCEDURE: Multigated Acquisition Scan|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Sargramostim|PROCEDURE: Therapeutic Conventional Surgery|DRUG: Thiotepa|DRUG: Topotecan Hydrochloride|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Flow in Hypercapnic Stable COPD Patients
Status: TERMINATED
Conditions: Adherence, Treatment
Interventions: DEVICE: Nasal High Flow installation|DEVICE: Non Invasive Ventilation|OTHER: Training session|OTHER: Education session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Function After Cardiac Surgery.
Status: RECRUITING
Conditions: Platelet Dysfunction
Interventions: DEVICE: Autologous blood cell salvage with in-house device|DEVICE: Autologous cell salvage with i-Sep SAME device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Laparoscopic vs Open Bilateral Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Inguinal Hernia Bilateral
Interventions: PROCEDURE: Laparoscopic bilateral inguinal hernia repair|PROCEDURE: Open bilateral inguinal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pontic Site Development With Connective Tissue Graft Using Modified Pouch Technique Versus Pouch Technique
Status: UNKNOWN
Conditions: Ridge Deficency|Soft Tissue Augmentation
Interventions: PROCEDURE: soft tissue augmentation using pouch technique|PROCEDURE: soft tissue augmentation using modified pouch technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Four Weeks-check Cystoscopy and Urine Cytology After Primary Complete Resection of T1 Bladder Cancer Replace Repeat Biopsy?
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: PROCEDURE: Outpatient check cytoscopy|DIAGNOSTIC_TEST: Urine cytology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience
Status: RECRUITING
Conditions: Alcohol Use Disorder|Alcohol Drinking|Substance Use|Drinking, Alcohol|Alcohol Use Disorder (AUD)
Interventions: DEVICE: Real TBS to the mPFC|DEVICE: Sham TBS to the mPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
Status: RECRUITING
Conditions: Stage I Uterine Corpus Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Diagnostic Imaging|PROCEDURE: Excisional Biopsy|DRUG: Indocyanine Green Solution|PROCEDURE: Minimally Invasive Surgery|PROCEDURE: Pelvic Lymphadenectomy|OTHER: Questionnaire Administration|PROCEDURE: Sentinel Lymph Node Mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Esomeprazole on Antiplatelet Action of Clopidogrel Associated With Aspirin
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Acute Myocardial Infarction
Interventions: DRUG: esomeprazole 20 mg daily|DRUG: famotidine 40 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Deucravacitinib in Participants With Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: BMS-986165|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compression Therapy as a Prophylactic Method Against CIPN: a Prospective Self-controlled Trial
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma|CIPN - Chemotherapy-Induced Peripheral Neuropathy
Interventions: OTHER: Pressurized gloves and foot caps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gabapentin Treatment of Alcohol Dependence
Status: COMPLETED
Conditions: Alcoholism|Alcohol Dependence
Interventions: DRUG: Gabapentin 900mg|BEHAVIORAL: behavioral counseling|DRUG: placebo|DRUG: gabapentin 1800mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 20101299: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: AMG 747|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Immune Globulin Plus Rituximab for Desensitization in Highly HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: BIOLOGICAL: Rituxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock
Status: RECRUITING
Conditions: Sepsis|Hypotension|Septic Shock
Interventions: DEVICE: NICOM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Polyene Phosphatidylcholine in Treatment of Patients With Acute Drug-induced Liver Injury
Status: COMPLETED
Conditions: Acute Drug Induced Liver Injury
Interventions: DRUG: Polyene phosphatidylcholine injection 930 mg QD|DRUG: Magnesium Isoglycyrrhizinate injection 200 mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
Status: RECRUITING
Conditions: Achalasia|Esophageal Spasm, Diffuse|Gastroparesis|Swallowing Disorder|Zenker Diverticulum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiation Therapy Boost Before Surgery for the Treatment of Non-metastatic Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Invasive Breast Carcinoma|Non-Metastatic Breast Carcinoma|Prognostic Stage 0 Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Boost|PROCEDURE: Therapeutic Surgical Procedure|RADIATION: Whole Breast Irradiation|OTHER: Breast MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: dexamethasone|DRUG: etoposide|DRUG: idarubicin|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: mesna|DRUG: pegaspargase|DRUG: therapeutic hydrocortisone|DRUG: thioguanine|DRUG: vincristine sulfate|RADIATION: low-LET cobalt-60 gamma ray therapy|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of BIA 9-1067 at Steady-state on the Pharmacokinetics of Levodopa/Carbidopa and Levodopa/Benserazide
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: BIA 9-1067|DRUG: Placebo|DRUG: levodopa/carbidopa|DRUG: levodopa/benserazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SIRPant-M in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Refractory Non-Hodgkin Lymphoma|Relapsed Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: SIRPant-M|RADIATION: External-beam radiotherapy (XRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: OTHER: Placebo|DRUG: GLWL-01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Axitinib (AG-013736) For the Treatment of Metastatic Renal Cell Cancer
Status: COMPLETED
Conditions: Kidney Neoplasms
Interventions: DRUG: Axitinib (AG-013736)|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Tivozanib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Accelerated Partial Breast Irradiation in Patients With Locally Recurrent or Second Primary Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Preoperative accelerated partial breast irradiation|PROCEDURE: Breast conserving surgery|PROCEDURE: Sentinel node procedure|PROCEDURE: Biopsy track removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperglycemia and Exercise.
Status: COMPLETED
Conditions: Aerobic Exercise|Hyperglycemia|Glucose Metabolism Disorders (Including Diabetes Mellitus)
Interventions: PROCEDURE: Steady-state hyperglycemia|PROCEDURE: Fluctuating hyperglycemia|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Performance of New 1-piece Ostomy Product
Status: COMPLETED
Conditions: Stoma Ileostomy
Interventions: DEVICE: Coloplast Adhesive baseplate A|DEVICE: Coloplast Adhesive baseplate B|DEVICE: Coloplast Adhesive baseplate C|DEVICE: SenSura 1-Piece
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders
Status: RECRUITING
Conditions: AML|ALL|MDS|MPD Withou Myelofibrosis|NHL or HL|Inherited Metabolic Disorders|Hemoglobinopathies|Bone Marrow Failure|HLH
Interventions: DRUG: Clofarabine|DRUG: Fludarabine|DRUG: Busulfan|DRUG: Cyclosporine-A|DRUG: Mycophenolate Mofetil|BIOLOGICAL: Cord Blood Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ozurdex for Diabetic Macular Edema Treated With Pars Plana vitrEctomy and Membrane RemovAl (OPERA Study)
Status: COMPLETED
Conditions: Diabetic Macular Edema|Epiretinal Membrane
Interventions: DRUG: Ozurdex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiplexing Prism Fitting for Field Expansion of Monocular Vision
Status: ACTIVE_NOT_RECRUITING
Conditions: One Eye Blindness|Blind Left Eye|Blind Right Eye
Interventions: DEVICE: Multiplexing Prism
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery
Status: UNKNOWN
Conditions: Pain, Postoperative|Anesthesia, Local|Opioid Use
Interventions: DRUG: Bupivacaine|DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CLAG Gleevec in Relapsed or Refractory Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: CLAG Regimen|DRUG: Gleevec®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Folfoxiri Plus Bev Followed by Reintroduction of Folfoxiri Plus Bev at Progression Versus Folfox Plus Bev Followed by Folfiri Plus Bev in mCRC
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: fluoruracil|DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Teriparatide|DRUG: calcium citrate|DRUG: Vitamin D|DRUG: TNF antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interaction Study to Assess the Effect of Repeat Doses of Rifampin on Mirabegron (YM178) in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics of YM178
Interventions: DRUG: mirabegron|DRUG: rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Nurse-led Family-oriented Resilience Program for Caregivers of Community-dwelling Dependent Older Adults
Status: SUSPENDED
Conditions: Caregiver Burden
Interventions: BEHAVIORAL: Evidence-based caregiving training|BEHAVIORAL: family resilience intervention|BEHAVIORAL: usual service
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Functional Imaging of Treatment Effects: A Companion Protocol to a Study of Extracranial Stereotactic Radioablation in Early Stage Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-small-cell Lung Cancer
Interventions: PROCEDURE: Functional Imaging of Treatment Effects
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: ACP-104 in Acutely Psychotic Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ACP-104|DRUG: ACP-104|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Liposomal Paclitaxel Plus Capecitabine in Chinese Patients With Advanced Gastric Carcinoma
Status: UNKNOWN
Conditions: Advanced Gastric Carcinoma
Interventions: DRUG: Liposomal paclitaxel plus capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Development of PATH, a Program to Support NICU Parent Mental Health Through the Transition From Hospital to Home
Status: RECRUITING
Conditions: Perinatal Depression|Perinatal Anxiety|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: PATH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of SDI-118 in Participants in Remission From Depression
Status: WITHDRAWN
Conditions: Depression in Remission
Interventions: DRUG: SDI-118|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Poliovirus Vaccine Trial in Bangladesh
Status: COMPLETED
Conditions: Healthy Infants
Interventions: BIOLOGICAL: Bivalent OPV 2 week interval|BIOLOGICAL: Bivalent OPV 4 week interval|BIOLOGICAL: Monovalent OPV 2 week interval|BIOLOGICAL: Monovalent OPV 4 week interval|BIOLOGICAL: Trivalent OPV 4 week interval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-Dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients
Status: RECRUITING
Conditions: Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|DIETARY_SUPPLEMENT: D Vitamin|PROCEDURE: Dual X-ray Absorptiometry|DRUG: Placebo Administration|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Far Red Light to Improve Functioning in PAD
Status: RECRUITING
Conditions: Peripheral Artery Disease|Peripheral Vascular Disease|Aging|Walking, Difficulty
Interventions: DEVICE: Far red light therapy|DEVICE: Sham light therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dual Eradication Therapy vs PPI on Gastrointestinal Bleeding in ACS Patients
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Helicobacter Pylori Infection
Interventions: DRUG: Vonoprazan-based dual eradication therapy for two weeks|DRUG: amoxicillin|DRUG: Pantoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ASC - Autism Study
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Gastrointestinal Dysfunction|Leaky Gut Syndrome|Mesenchymal Stromal Cells|Inflammatory Bowel Diseases
Interventions: DRUG: Adipose tissue derived mesenchymal stromal/stem cells (Cell2Cure®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Levosimendan Administration in Pulmonary Hypertension
Status: COMPLETED
Conditions: Hypertension, Pulmonary|Cardiac Failure|Pulmonary Vascular Resistance Abnormality
Interventions: DRUG: levosimendan at a dose of 3 mcg/kg|DRUG: levosimendan at a dose of 6 mcg/kg|DRUG: levosimendan at a dose of 12 mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assess the Efficacy and Safety of Multi-target Therapy in Lupus Nephritis
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: DRUG: Tacrolimus+Mycophenolate mofetil|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Consuming Oat Bran Mixed in Water Before a Meal on Glycemic Responses in Healthy Humans - a Pilot Study
Status: COMPLETED
Conditions: Glucose Intolerance
Interventions: OTHER: 0 grams oat bran|OTHER: 4.5 grams oat bran|OTHER: 13.6 grams oat bran|OTHER: 27.3 grams oat bran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of and Immune Response to an HIV-1 Vaccine Boost (VRC-HIVADV014-00-VP) in HIV Uninfected Adults Who Participated in HVTN 052
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC-HIVADV014-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study to Determine the Metabolism and Elimination of 14C-E7080 in Patients With Advanced Solid Tumors or Lymphomas, Who Are Unsuitable For, or Have Failed, Existing Therapies.
Status: COMPLETED
Conditions: Advanced Solid Tumors|Lymphomas
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multifunctional Magnetic Resonance Imaging in Predicting Breast Lesions in Women Undergoing Mastectomy for Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: gadolinium-chelate|PROCEDURE: conventional surgery|PROCEDURE: magnetic resonance imaging|PROCEDURE: magnetic resonance spectroscopic imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Lumbar Fusion When NanOss Bioactive Is Used With Posterolateral Gutter Fusions
Status: TERMINATED
Conditions: Degenerative Disc Disease|Spinal Stenosis|Spondylolisthesis
Interventions: DEVICE: nanOss Bioactive Bone void filler|DEVICE: Interbody FCage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Meal Patterning on Carotenoid Absorption From Vegetables
Status: COMPLETED
Conditions: Carotenoid|Bioavailability|Dietary Modification
Interventions: OTHER: Meal Pattern Treatment A|OTHER: Meal Pattern Treatment B|OTHER: Meal Pattern Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Effect of Patient Portal Messaging Before Mailing Fecal Immunochemical Testing Kit on Colorectal Cancer Screening Rates
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Neoplasms|Colorectal Cancer Screening
Interventions: BEHAVIORAL: MyChart Priming Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Lidocaine Block in Traumatic Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Rehabilitation therapy|PROCEDURE: Stellate ganglion block|DRUG: Lidocaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of General Anaesthesia and Sedation on the Stone Fragmentation in Lithotripsy
Status: UNKNOWN
Conditions: Urolithiasis
Interventions: OTHER: Anaesthesia and Lithotripsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Benralizumab Efficacy in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History
Status: COMPLETED
Conditions: Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Benralizumab Arm A|DRUG: Benralizumab Arm B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rural Veterans With Post-traumatic Stress Disorder (PTSD) And Comorbid Mild Traumatic Brain Injury (TBI): A Feasibility Study
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorders|Traumatic Brain Injury
Interventions: BEHAVIORAL: Control|BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Sacral Nerve Modulation and Pudendal Nerve Stimulation in Treatment of Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: PROCEDURE: Sacral nerve modulation|PROCEDURE: Pudendal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozine on Systemic and Renal Endothelial Function
Status: UNKNOWN
Conditions: Endothelial Function|Type 2 Diabetes
Interventions: DRUG: Metformin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis.
Status: RECRUITING
Conditions: Lyme Borreliosis|Physical Activity|Lyme Borreliosis, Nervous System
Interventions: OTHER: physical activity program|OTHER: Advice and recommendations of physical activity at home
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of the Self-expanding Intracranial Stent (Tonbridge) for Endovascular Treatment of Intracranial Aneurysms
Status: RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DEVICE: Self-expanding Intracranial Stent (Tonbridge)|DEVICE: LVIS and LVIS Jr. (MicroVention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors
Status: TERMINATED
Conditions: Non-Hodgkin Lymphoma|Hodgkin Lymphoma|Kaposi Sarcoma|Gastric Cancer|Nasopharyngeal Cancer|EBV|Castleman Disease
Interventions: DRUG: Nelfinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-DM1 With Abraxane and Lapatinib for Metastatic HER2 Positive Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: T-DM1|DRUG: Lapatinib|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing BL-B01D1 With Platinum Based Chemotherapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BL-B01D1|DRUG: Pemetrexed+Cisplatin or Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Apatinib Combined With TACE in Patients With Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Refractory to Transcatheter Arterial Chemoembolization
Interventions: DRUG: Apatinib|RADIATION: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Thermogenic Dietary Supplement on Metabolic, Hemodynamic, and Mood Responses
Status: COMPLETED
Conditions: Energy Metabolism|Heart Rate|Blood Pressure|Mood
Interventions: DRUG: Sugar Pill (placebo)|DIETARY_SUPPLEMENT: Caffeine (plus Teacrine and Cayenne)|DIETARY_SUPPLEMENT: Caffeine (plus Teacrine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Study Comparing Safety and Immunogenicity of bOPV of Bilthoven Biologicals
Status: COMPLETED
Conditions: Immune Response to Oral Polio Vaccine
Interventions: BIOLOGICAL: Part 1 study - BBio bOPV|BIOLOGICAL: Part 2 study - BBio bOPV Lot 1|BIOLOGICAL: Part 2 study - BBio bOPV Lot 2|BIOLOGICAL: Part 2 study - BBio bOPV Lot 3|BIOLOGICAL: Part 2 study - Licensed bOPV|BIOLOGICAL: Part 1 study - Licensed bOPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility and Usability of Intraoperative Fluorescent Angiography With Indocyanine Green in Penetrating Abdominal Trauma
Status: COMPLETED
Conditions: Abdominal Injuries
Interventions: DIAGNOSTIC_TEST: Indocyanine Green
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity and Safety of Adjuvanted Reduced Dose Inactivated Polio Vaccine Given as a Booster at Age 15-18 Months
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: IPV-Al SSI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer NSCLC
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: Abraxane + carboplatin|DRUG: Gemcitabine + cisplatin|DRUG: Gemcitabine + carboplatin|DRUG: Pemetrexed + carboplatin|DRUG: Pemetrexed + cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuation of Nintedanib After Single Lung Transplantation in IPF Subjects
Status: TERMINATED
Conditions: Idiopathic Pulmonary Fibrosis|Lung Transplant; Complications
Interventions: DRUG: Nintedanib|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors
Status: COMPLETED
Conditions: Teratoid Tumor, Atypical|Choroid Plexus Neoplasms|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Brainstem Tumors|Giant Cell Glioblastoma|Glioblastoma|Gliosarcoma|Medulloblastoma|Neuroectodermal Tumor, Primitive
Interventions: DRUG: azurin-derived cell-penetrating peptide p28
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: COMBINATION_PRODUCT: Controlled low central venous pressure (CLCVP) technology|DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prevention of Arthritis-Related Work Disability
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Systemic Lupus Erythematosus|Osteoarthritis, Knee|Ankylosing Spondylitis
Interventions: OTHER: Rehabilitation counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Thalamic Deep Brain Stimulation for Secondary Dystonia in Children and Young Adults
Status: COMPLETED
Conditions: Dystonia
Interventions: DEVICE: Activa PC Primary Cell Neurostimulator - (Model 37601)|DEVICE: Activa RC Rechargeable Neurostimulator - (Model 37612)|DEVICE: Activa SC Single Cell Neurostimulator (Models 37602/37603)|DEVICE: DBS Lead - (Model 3387|DEVICE: DBS Extension - (Models 37085/6)|DEVICE: Patient Programmer - (Model 37642)|DEVICE: Test Stimulator - (Model 3625)|DEVICE: N'Vision Clinician Programmer - (Model 8840)|DEVICE: N'Vision Software Application Card - (Model 8870)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Fruquintinib in Combination With Gefitinib in Patients With Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: NSCLC
Interventions: DRUG: Fruquintinib|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Calcium Hydroxide With Silver Nanoparticle and Conventional Calcium Hydroxide Intra Canal Medications on Post-Operative Pain in Symptomatic Root Canal Treatment Failure Cases:
Status: COMPLETED
Conditions: Retreatment|Root Canal Retreatment|Nonsurgical Retreatment|Endodontic Failure|Symptomatic Endodontic Failure|Nanosilver|Intracanal Medicament|Intracanal Dressing|AgNPs|Calcium Hydroxide|Ca (OH)2|Discomfort|Pain|Flare up|Postoperative|Ache|Post-operative|Post Obturation
Interventions: COMBINATION_PRODUCT: silver nano particulate solution mixed with calcium hydroxide powder|COMBINATION_PRODUCT: conventional calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT