pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) Screening: a Pilot Randomized Clinical Trial
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Microdrop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 6-7 μL)]|DRUG: Standard drop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 28-34 μL)]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: TP-6076|PROCEDURE: Bronchoalveolar lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Comparison of Effectiveness Between Epidural Combined Bilateral US TAP Block Versus Epidural Alone for Gynaecology Operation.
Status: RECRUITING
Conditions: Gynecologic Disease
Interventions: OTHER: Bilateral US TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD
Status: TERMINATED
Conditions: Heart Failure
Interventions: BIOLOGICAL: Mesenchymal Precursor cells (RevascorTM)|DRUG: Cryoprotective media alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
Status: COMPLETED
Conditions: Emphysema|Chronic Obstructive Pulmonary Disease (COPD)|Cystic Fibrosis|Pulmonary Fibrosis|Bronchiectasis|Sarcoidosis|Pulmonary Hypertension|Alpha-1 Antitrypsin Deficiency
Interventions: PROCEDURE: Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™|DEVICE: STEEN Solution™
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elective Percutaneous Coronary Intervention With or Without Supplemental OXYgen
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DRUG: Oxygen gas|OTHER: Ambient air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Demonstrate the Equivalence of CT-P10 to MabThera With Respect to the Pharmacokinetic Profile in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Air Pollution on the Course of Inflammatory Rheumatism
Status: ACTIVE_NOT_RECRUITING
Conditions: Rheumatoid Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis
Interventions: OTHER: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical Patients
Status: RECRUITING
Conditions: Pain, Postoperative|Pain, Acute|Pain, Chronic|Anesthesia
Interventions: DRUG: Methadone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: You Are What You Eat: A Randomised Controlled Trial of an Appearance-based Dietary Intervention
Status: COMPLETED
Conditions: Fruit and Vegetable Consumption
Interventions: BEHAVIORAL: Information-only|BEHAVIORAL: Generic appearance intervention|BEHAVIORAL: Personalised appearance intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Higher Frequency Zoledronic Acid in the Treatment of Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: dexamethasone|DRUG: thalidomide|DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Self-determination for Institutionalized Older People Without Decision-making Capacity: Advance Care Planning by Proxy
Status: COMPLETED
Conditions: Advanced Dementia|Loss of Medical Decision Making Capacity
Interventions: OTHER: Advance care planning by proxy for health care proxies of people without medical decision making capacity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adjuvant Erlotinib Intercalating Chemotherapy or Adjuvant Chemotherapy Alone in NSCLC With Common EGFR Mutation
Status: WITHDRAWN
Conditions: NSCLC
Interventions: DRUG: intercalation therapy using pemetrexed, cisplatin and erlotinib|DRUG: Vinorelbine, cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CGF on Short Term Clinical Outcomes After Partially Impacted Mandibular Third Molar Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Trismus|Edema
Interventions: PROCEDURE: Concentrated growth factor|OTHER: Non-Concentrated growth factor Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Margetuximab and Pembrolizumab for Advanced, Metastatic HER2(+) Gastric or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Stomach Cancer|Esophageal Cancer
Interventions: BIOLOGICAL: Margetuximab 10 mg/kg|BIOLOGICAL: Margetuximab 15 mg|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SofWave Treatment to Lift Lax Tissue in the Submental and Neck Zones and to Lift the Eyebrow
Status: COMPLETED
Conditions: Skin Laxity|Wrinkle|Brow Lifting
Interventions: DEVICE: Sofwave Treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and Biological Therapy in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Breast Cancer|Cervical Cancer|Colorectal Cancer|Lung Cancer|Ovarian Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: mutant p53 peptide pulsed dendritic cell vaccine|BIOLOGICAL: ras peptide cancer vaccine|BIOLOGICAL: sargramostim|BIOLOGICAL: therapeutic autologous lymphocytes|BIOLOGICAL: therapeutic tumor infiltrating lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Validation of Appetite Method Visual Analogue Scales in Home-setting: VASA-home
Status: COMPLETED
Conditions: Overweight and Obesity|Appetitive Behavior
Interventions: OTHER: Wheat home-based appetite assessment|OTHER: Rye home-based appetite assessment|OTHER: Wheat clinic-based appetite assessment|OTHER: Rye clinic-based appetite assessment|OTHER: Rye/Wheat clinic-based appetite assessment with blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial for the Use of a Novel Cell Collector Device to Retrieve Cells From the Uterine Cervix
Status: COMPLETED
Conditions: Uterine Cervical Dysplasia|Uterine Cervical Intraepithelial Neoplasia|Uterine Cervical Neoplasia|Uterine Cervical Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial Assessing 5-HT3 Receptor Antagonist (Ramosetron) for the Treatment of Anterior Resection Syndrome
Status: UNKNOWN
Conditions: Anterior Resection Syndrome
Interventions: DRUG: Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, PK of GC2129A in Healthy Volunteers Under Fasting Conditions
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: GC2129A(Period 1)|DRUG: Linaglptin 5mg and Metformin Hydrocholoride 1000mg(Period 1)|DRUG: GC2129A(Period 2)|DRUG: Linaglptin 5mg and Metformin Hydrochloride 1000mg(Period 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Spironolactone|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 4 Study of the Efficacy of Losartan Based Therapy in Hypertensives With and Without Diabetes
Status: WITHDRAWN
Conditions: Diabetes Mellitus|Hypertension
Interventions: DRUG: Losartan 50Mg Tab|DRUG: Losartan/Hydrochlorothiazide 50 Mg-12.5 Mg ORAL TABLET|DRUG: Losartan/Hydrochlorothiazide 100 Mg-25 Mg ORAL TABLET|DRUG: Amlodipine 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation + PVI vs PVI Alone for Persistent AF
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: catheter ablation|DEVICE: renal artery denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care (Study II)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: tiotropium 5mcg/day|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Pimavanserin 34 mg Capsule
Status: COMPLETED
Conditions: Parkinson Disease Psychosis
Interventions: DRUG: Pimavanserin 34 mg|DRUG: NUPLAZID 34 MG Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bioequivalence Study of Atorvastatin Calcium Tablets, 40 mg Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Atorvastatin Calcium Tablets, 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensive Home-based Bimanual and Lower-limb Training in Young Children With Hemiplegia
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Intensive Home-based Bimanual and Lower-limb Training in Young Children With Hemiplegia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Perioperative Clopidogrel Responsiveness on Ischemic Outcome in Patients With Acute Coronary Syndrome Undergoing Off-pump Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Acute Coronary Syndrome (ACS)
Interventions: DEVICE: MACE after OPCAB|DEVICE: without MACE after OPCAB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of an Investigational Compound on Tolerability of Extended Release Niacin (0524A-023)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesteremia|Hyperlipidemia
Interventions: DRUG: MK-0524A|DRUG: ER Niacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis.
Status: COMPLETED
Conditions: Rhizarthrosis
Interventions: DRUG: infiltration of corticosteroids|DRUG: infiltration of corticosteroids and hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Investigating the Safety, Tolerability, and PK, PD, of CB-0406
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CB-0406 100 mg|DRUG: CB-0406 200 mg|DRUG: CB-0406 400 mg|DRUG: CB-0406 800 mg|DRUG: CB-0406 1,000 mg|DRUG: Matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia TrEatment Study
Status: TERMINATED
Conditions: Tachycardia|Dyspnea|COVID-19
Interventions: DRUG: Metoprolol Succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MPDL3280A-imaging-IST-UMCG
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors Irrespective of PD-L1 Expression
Interventions: OTHER: 89Zr-MPDL-3280A-PET scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Doubled Quadrupled Versus Quadrupled Allograft Tissue Constructs for Anterior Cruciate Ligament (ACL) Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament|Injury
Interventions: PROCEDURE: ACL reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
Status: COMPLETED
Conditions: Hyperuricosuria|Kidney Stones
Interventions: DRUG: Febuxostat|DRUG: Allopurinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Orelabrutinib,Rituximab and Methotrexate in Newly-diagnosed Primary Central Nervous System Lymphoma(PCNSL)
Status: RECRUITING
Conditions: Primary Central Nervous System Lymphoma
Interventions: DRUG: Orelabrutinib,Rituximab and Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PF-05208756, Moroctocog Alfa (AF-CC), Xyntha For Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Intravenous infusions of Xyntha
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)
Status: COMPLETED
Conditions: Acute Lung Injury|Acute Respiratory Failure
Interventions: OTHER: O2 conventional|DEVICE: O2-HFN : high flow nasal oxygen therapy|DEVICE: O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of rhTSH for Adjuvant Radioiodine Ablation Therapy in Patients With Differentiated Thyroid Cancer
Status: RECRUITING
Conditions: Differentiated Thyroid Cancer
Interventions: BIOLOGICAL: rhTSH|RADIATION: Radioiodine (131I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of MG-K10 Humanized Monoclonal Antibody Injection in Healthy Adult Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Pharmacokinetics
Interventions: DRUG: MG-K10 humanized monoclonal antibody injection (prefilled syringe)|DRUG: MG-K10 humanized monoclonal antibody injection（Penicillin bottle）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Daratumumab as Maintenance After Peripheral Blood Stem Cell Transplantation From HLA-identical or Haploidentical Family Donor in the Treatment of Refractory or Relapsed Multiple Myeloma: a Phase 2 Trial
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Development and Evaluation of iCF-PWR for Healthy Siblings of Individuals With Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis|Siblings|Mental Health|Internet-based Intervention
Interventions: BEHAVIORAL: Internet-delivered Cystic Fibrosis Mental Health Prevention, Wellness, and Resource (iCF-PWR) program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sacral Neuromodulation in Dual Incontinence: Ultrasound and Afferent Nerve Sensation Assessment
Status: TERMINATED
Conditions: Dual Incontinence|Fecal Incontinence|Urinary Incontinence|Sacral Neuromodulation
Interventions: DEVICE: Neurometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metabolomic Study in Exhaled Breath Condensate of Thoracic Surgical Patients
Status: UNKNOWN
Conditions: Acute Pulmonary Insufficiency Following Thoracic Surgery|Ventilator-associated Lung Injury
Interventions: PROCEDURE: Thoracic Surgery with Lung Resection|PROCEDURE: Thoracic Surgery without Lung Resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot RCT of the PRISM Intervention for AYAs With Cancer
Status: COMPLETED
Conditions: Cancer|Acute Lymphoblastic Leukemia|Lymphoma|Sarcoma|Acute Myelogenous Leukemia|Brain Tumors|Germ Cell Tumor
Interventions: BEHAVIORAL: Promoting Resilience In Stress Management (PRISM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ECCO2R as an Adjunct to NIV in AECOPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: NIV|DEVICE: ECCO2R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ACTION ON COVID-19: A Study to Test Whether BI 764198 Helps Lung Health of People Hospitalised With COVID-19
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: BI 764198|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Frequent Dosing Regimen of Lucentis for Subjects With Persistent Diabetic Macular Edema Despite Standard antiVEGF Dosing
Status: WITHDRAWN
Conditions: Persistent Diabetic Macular Edema
Interventions: DRUG: ranibizumab|DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PEG-Interferon Alfa-2b in Treating Patients With Platinum-Resistant Ovarian Epithelial, Peritoneal, or Fallopian Tube Cancer
Status: TERMINATED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: PEG-interferon alfa-2b|DRUG: PEG-interferon alfa-2b|BIOLOGICAL: PEG-interferon alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma
Status: COMPLETED
Conditions: CNS Cancer|Meningioma|Intracranial Hemangiopericytoma|Hemangioblastoma|Neurofibromatosis
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Study of Safety, Tolerability, and Efficacy of TLC-2716 in Subjects With Hypertriglyceridemia and NAFLD
Status: RECRUITING
Conditions: Hypertriglyceridemia|Nonalcoholic Fatty Liver Disease
Interventions: DRUG: TLC-2716 Dose 1|DRUG: TLC-2716 Dose 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: TheraBionic Device|DEVICE: Placebo Device|DEVICE: Quality of Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PETACC-8 miR-31-3p and miR-31-5p Ancillary Study
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Different Endoscopic Preparations Used in Pediatric Colonoscopy
Status: UNKNOWN
Conditions: Digestive Illness
Interventions: DRUG: Polyethylene Glycol 4000 with electrolytes|DRUG: PEG-3350 with electrolytes|DRUG: Sodium picosulfate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I/II Study of Weekly Docetaxel and Cisplatin Together With Capecitabine and Bevacizumab in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Advanced Gastric Cancer
Interventions: DRUG: Docetaxel, Cisplatin, Capecitabine, Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: ketamine full dose|DRUG: Midazolam|DRUG: Normal saline|DRUG: ketamine half dose|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis
Status: RECRUITING
Conditions: Colorectal Carcinoma|Ulcerative Colitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Endovascular Repair of Descending Thoracic Aortic Aneurysms
Status: COMPLETED
Conditions: Aortic Aneurysm, Thoracic
Interventions: DEVICE: Endovascular thoracic aortic aneurysm repair using TALENT TAA Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating DyNamic Myocardial Blood Flow QUantitation As a Cost Effective Care ModeL for DiabEtic Patients With Coronary Artery DiSease
Status: RECRUITING
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: RADIATION: Myocardial perfusion imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Time Restricted Diet in Obese or Overweight Pre or Postmenopausal Participants
Status: TERMINATED
Conditions: Healthy, no Evidence of Disease|Obesity
Interventions: BEHAVIORAL: behavioral dietary intervention|BEHAVIORAL: telephone-based intervention|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison DW-MRI vs FDG PET/CT in the Detection of Early Recurrence of Cervical Well-differentiated Thyroid Carcinoma
Status: COMPLETED
Conditions: Thyroid Cancer|Relapse
Interventions: DEVICE: PET|DEVICE: MRI imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Low Dose Decitabine in Combination With Tirelizumab Comparison of Tirelizumab in the First-line Treatment of Advanced Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: PFS
Interventions: DRUG: Decitabine Injection|DRUG: tirelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pentazocine Versus Lorazepam on Manic Symptoms
Status: COMPLETED
Conditions: Bipolar Disorder|Schizoaffective Disorder|Manic Disorder|Mania|Manic State
Interventions: DRUG: Pentazocine|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise Given to Factory Workers With Ergonomics Training on Pain and Functionality
Status: COMPLETED
Conditions: Work-related Illness|Work Accident|Occupational Diseases
Interventions: OTHER: control|OTHER: exercise group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of JPI-547 in Platinum-resistant, Advanced/Relapsed Ovarian Cancer Subjects Previously Treated With a PARP Inhibitor
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: JPI-547
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ficlatuzumab, Cisplatin and IMRT in Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: TERMINATED
Conditions: Carcinoma, Squamous Cell of Head and Neck
Interventions: DRUG: Ficlatuzumab|DRUG: Cisplatin|RADIATION: Intensity Modulated Radiotherapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neuroimaging and CBD for Opiod Use Disorder
Status: RECRUITING
Conditions: Heroin Abuse|Opioid Use Disorder|Substance-Related Disorders|Opioid-Related Disorders
Interventions: DRUG: Cannabidiol (CBD)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)|CKD Stage 3|CKD Stage 4|CKD Stage 5|Diabetes Mellitus|Diabetic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: PLAFOND diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Casea S Contraceptive Implants (Casea S) Trial
Status: RECRUITING
Conditions: Contraception
Interventions: DRUG: 22.2 mg Etonogestrel (ENG)|DRUG: 44.4 mg Etonogestrel (ENG)|DRUG: 22.2-66.6 mg Etonogestrel (ENG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Senior Driving Simulation Training for Subjective Cognitive Decline and Mild Cognitive Impairment
Status: COMPLETED
Conditions: MCI|Subjective Cognitive Decline|Healthy Aging
Interventions: OTHER: Senior Driving Simulation Training|OTHER: Waiting list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of BNT162b2 Coadministered With SIIV in Adults 18 Through 64 Years of Age
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: BNT162b2|OTHER: Placebo|BIOLOGICAL: Seasonal Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nintedanib and Azacitidine in Treating Participants With HOX Gene Overexpression Relapsed or Refractory Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A|Fibroblast Growth Factor Basic Form Measurement|FLT3 Internal Tandem Duplication|Recurrent Adult Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|OTHER: Laboratory Biomarker Analysis|DRUG: Nintedanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Effects of Clarithromycin on Pharmacokinetics of JNJ-54861911 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-54861911, 25 mg|DRUG: Itraconazole 200 mg|DRUG: Clarithromycin 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracytoplasmic Sperm Injection in Non-male Factor Infertility in Advanced Maternal Age
Status: UNKNOWN
Conditions: Infertility, Female|ART
Interventions: PROCEDURE: ICSI|PROCEDURE: IVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Concomitant Chemotherapy in Patients With Locally Advanced HNSCC Treated by Radiotherapy-erbitux
Status: COMPLETED
Conditions: HNSCC
Interventions: DRUG: cetuximab|DRUG: Carboplatin, 5FU concomitant|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Non-invasive Oxygenation Strategies in Patients Admitted for Covid-19 Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Interventions: OTHER: Use of High Flow Nasal Cannula alone|OTHER: Use of Non-invasive Ventilation|OTHER: Use of Continuous Positive Airway Pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus
Interventions: OTHER: Clinical and laboratory evaluations, transesophageal echocardiography, carotid duplex, transcranial duplex, and magnetic resonance of the brain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Eblasakimab in Male or Female Moderate-to-Severe Atopic Dermatitis Patients Previously Treated With Dupilumab
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DRUG: Placebo|DRUG: ASLAN004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Reduction With Topical Bromfenac Versus Artificial Tear After Intravitreal Injection.
Status: COMPLETED
Conditions: Pain|Intravitreal Injection|Pain, Acute
Interventions: DRUG: Use of bromfenac 0.09% to reduce intravitreal injection pain|DRUG: Use of artificial tears to reduce intravitreal injection pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation
Status: TERMINATED
Conditions: Ventilator Induced Diaphragm Dysfunction
Interventions: DEVICE: Lungpacer Diaphragm Pacing Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in Human (FIH) Trial of ETH-155008 in Subjects With B-NHL, CLL/SLL and AML
Status: TERMINATED
Conditions: NHL|Leukemia
Interventions: DRUG: ETH-155008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of a New Protease Inhibitor, BMS-232632, in HIV-Positive Patients Who Have Received Previous Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atazanavir|DRUG: Ritonavir|DRUG: Saquinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Anti-CLL1 CAR T-cell Therapy in CLL1 Positive Relapsed/Refractory Acute Myeloid Leukemia (AML)
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: anti-CLL1 CART
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Artacent™ for Treatment Resistant Lower Extremity Venous and Diabetic Ulcers
Status: UNKNOWN
Conditions: Venous Ulcer|Foot Ulcer, Diabetic
Interventions: OTHER: Artacent Human Amniotic Membrane|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of LM-108 as a Single Agent or in Combination With Pembrolizumab in Subjects With Advanced Solid Tumours
Status: TERMINATED
Conditions: Advanced Solid Tumor
Interventions: DRUG: LM-108|DRUG: An Anti-PD-1 Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Dose Finding Study of 2 Dosages of CHF 4226 pMDI (Carmoterol) in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: carmoterol (CHF 4226)|DRUG: carmoterol (CHF 4226)|DRUG: placebo|DRUG: salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Artesunate-Amodiaquine and Artemether-Lumefantrine for the Treatment of Malaria in Yaounde
Status: COMPLETED
Conditions: Malaria,Falciparum
Interventions: DRUG: Artesunate-amodiaquine combination|DRUG: Artemether, Lumefantrine Drug Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2605541 in Participants With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: LY2605541|DRUG: Insulin Lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inpatient Group Acceptance and Commitment Therapy (ACT) for Psychosis Spectrum Disorder
Status: RECRUITING
Conditions: Psychotic Disorders|Acceptance and Commitment Therapy|Psychotherapy, Group|Inpatients
Interventions: BEHAVIORAL: ACT group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Substance Abuse and Trauma in Incarcerated Women
Status: COMPLETED
Conditions: Substance Abuse|Trauma|Post Traumatic Stress Disorder|Integrated Treatment|Incarcerated Women
Interventions: BEHAVIORAL: Helping Women Recover/Beyond Trauma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Imagery Rescripting With and Without Reconsolidation Disruption
Status: COMPLETED
Conditions: Fear of Failure
Interventions: BEHAVIORAL: ImRs-DSR|BEHAVIORAL: ImRs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial to Evaluate Zevor-cel (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: zevor-cel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Women With Overweight or Obesity to Test Whether Different Doses of BI 456906 Influence the Amount of a Contraceptive in the Blood
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: BI 456906|DRUG: Microgynon®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance and Safety of Restylane Lidocaine for Treatment of Depressed Facial Acne Scars
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: Restylane Lidocaine|OTHER: No-treatment control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the GLP-1 Exenatide on Satiety in Lean and Obese Women
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Exenatide|DRUG: Normal saline .2cc subcutaneous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: DRUG: warfarin|DRUG: apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Duloxetine Hydrochloride Hard Gelatinous Capsule Compared To Cymbalta
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: Cymbalta Capsules|DRUG: Duloxetine Hydrochloride Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate Safety, Tolerability, and PD of Tegoprazan on Healthy Male Volunteers
Status: COMPLETED
Conditions: Pharmacodynamics|Healthy Male Volunteers
Interventions: DRUG: Tegoprazan|DRUG: Revaprazan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metabolic Availability of Methionine in Mung Beans
Status: NOT_YET_RECRUITING
Conditions: Healthy Women of Child Bearing Potential
Interventions: DIETARY_SUPPLEMENT: Metabolic availability of methionine in mung beans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System.
Status: RECRUITING
Conditions: Arthroplasty|Replacement|Knee
Interventions: DEVICE: CORI™ KNEE TENSIONER
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IMC-1121B (Ramucirumab) in Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Carcinoma
Interventions: BIOLOGICAL: IMC-1121B (ramucirumab)|DRUG: Oxaliplatin|DRUG: Folinic acid|DRUG: 5-FU|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 'HI-4-TU' Study: Health Improvement for Teen Ugandans Study
Status: COMPLETED
Conditions: Pregnancy|Human Immunodeficiency Virus|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: enhanced group support|BEHAVIORAL: enhanced individual support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ethiopia Malaria Therapeutic Efficacy Study
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Chloroquine- P. vivax|DRUG: Artemether-Lumefantrine: P. vivax|DRUG: Artemether-lumefantrine: P. falciparum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Two-Way Communication Checklist (2-COM) in First Episode Psychosis Patients in Hong Kong
Status: COMPLETED
Conditions: Schizophrenia|Communication
Interventions: OTHER: The Two-Way Communication Checklist|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Dose Study of Controlled-Release Paroxetine Tablets in Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: Paroxetine 12.5 milligrams tablet|DRUG: Paroxetine 25 milligrams tablet|DRUG: Paroxetine 50 milligrams tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of Single Oral Doses Of PF-03716539 In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-03716539|DRUG: PF-03716539|DRUG: PF-03716539|OTHER: Placebo|DRUG: PF-03716539|DRUG: PF-03716539|DRUG: PF-03716539|OTHER: Placebo|DRUG: Midazolam|DRUG: Midazolam + PF-03716539 (100 mg)|DRUG: Midazolam + PF-03716539 (50 mg)|DRUG: Darunavir|DRUG: Darunavir + PF-03716539|DRUG: Maraviroc|DRUG: Maraviroc +PF-03716539|DRUG: Maraviroc|DRUG: Maraviroc +PF-03716539
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AVT03 With Prolia in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: BIOLOGICAL: AVT03|BIOLOGICAL: Prolia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone
Status: TERMINATED
Conditions: Tenosynovitis
Interventions: DRUG: Treatment Group: Corticosteroid injection|DRUG: Control Group (corticosteroid alone)|DRUG: Treatment Group: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Top-down Infliximab Study in Kids With Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Infliximab|DRUG: Prednisolone|OTHER: Exclusive enteral nutrition|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab in Primary Lymphocyte Predominant Hodgkin´s Disease(RIPL)
Status: COMPLETED
Conditions: Lymphocyte Predominant Hodgkin´s Lymphoma (LPHD)
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haemostatic Gel Prophylaxis for Post Duodenal Endoscopic Resection Bleeding
Status: RECRUITING
Conditions: Duodenal Bleeding
Interventions: PROCEDURE: duodenal mucosectomy|PROCEDURE: ampullectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimal Treatment Strategies for Sexually Abused Children
Status: COMPLETED
Conditions: Child Abuse, Sexual
Interventions: BEHAVIORAL: Trauma focused cognitive behavioral therapy (TF-CBT)|BEHAVIORAL: Brief abuse-focused treatment|BEHAVIORAL: Brief coping skills treatment|BEHAVIORAL: Extended abuse-focused treatment|BEHAVIORAL: Extended coping skills treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Organoleptic Perception of Oral Nutritional Supplements for Oncological Patients
Status: COMPLETED
Conditions: Cancer|Nutrition Related Cancer|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Flavoured Oral Nutritional Supplement (ONS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Effect of Phototherapy With Light Emitting Diode (LED) on Muscle and Pulmonary Oxygen Consumption on Diabetes Mellitus
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Phototherapy through light emitting diode (LED) - 150J|DEVICE: Placebo phototherapy - 150J|DEVICE: Phototherapy through light emitting diode (LED) - 300J|DEVICE: Placebo phototherapy - 300J
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing RadiaPlexRx Hydrogel and Standard-of-Care for Radiation Dermatitis in Breast Cancer Patients
Status: COMPLETED
Conditions: Radiation Dermatitis
Interventions: OTHER: RadiaPlexRx Gel|OTHER: Aquaphor Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Patients With Chronic Tension-type Headache
Status: COMPLETED
Conditions: Chronic Tension-Type Headache
Interventions: OTHER: acupuncture|OTHER: superficial acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Dosing Schedule of Inhaled Bronchodilator for Endotracheally Intubated COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Bronchodilators inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT