pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase I Study of 5-Fluorouracil in Children and Young Adults With Recurrent Ependymoma
Status: COMPLETED
Conditions: Central Nervous System Malignancies|Ependymoma
Interventions: DRUG: 5-fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Improvement in Control of Diabetes Influences the Production of a Hormone Produced in the Gut Which Improves the Release and Action of Insulin.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Glimepiride|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery and Neuroablative Procedures in Spasticity
Status: COMPLETED
Conditions: Upper Extermity Spasticity|Multidisciplinary Approach|Novel Algorithm|Diagnostic Nerve Block|Surgery|Percutaneous Neuroablative Procedures|Refractory Spasticity
Interventions: PROCEDURE: Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of IDN-6556 in Cirrhotic Subjects With Portal Hypertension
Status: COMPLETED
Conditions: Liver Cirrhosis|Hepatic Cirrhosis|Portal Hypertension
Interventions: DRUG: IDN-6556
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Intravitreal Aflibercept Injection in Eyes With Wet Age-related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Macular Degeneration
Interventions: DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety Study of GMDTC Injection in Healthy Participants
Status: COMPLETED
Conditions: Cadmium Exposure
Interventions: DRUG: GMDTC for injection|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Safety and Efficacy of Adalimumab in Chinese Subjects With Moderate to Severe Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: adalimumab|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HX008 Plus Chemotherapy VS Pembrolizumab Plus Chemotherapy As the First-line Treatment in Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Nonsquamous Non-small Cell Lung Cancer
Interventions: DRUG: HX008|DRUG: Pembrolizumab|DRUG: pemetrexed|DRUG: cisplatin/carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Laninamivir Octanoate TwinCaps® Dry Powder Inhaler in Adults With Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: 40 mg Laninamivir Octanoate|DRUG: 80 mg Laninamivir Octanoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Intragastric Fructose Infusion on Behavioural and Neural Responses to Negative Emotion Induction
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Fructose|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Disitamab Vedotin Combined With Tislelizumab in Advanced HER2 Positive Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Neoplasms
Interventions: DRUG: Disitamab vedotin|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persona Total Knee Arthroplasty Outcomes Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Pain Chronic|Osteoarthritis|Rheumatoid Arthritis|Traumatic Arthritis|Polyarthritis|Moderate Varus, Valgus or Flexion Deformities|Avascular Necrosis of the Femoral Condyle
Interventions: DEVICE: Zimmer Persona Total Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo Breakfast Consumption, Appetite and Food Intake
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Placebo breakfast|DIETARY_SUPPLEMENT: Typical whole-food breakfast|DIETARY_SUPPLEMENT: Water-only control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Efficacy of Topiramate in Patients With Prader Willi Syndrome Over 8 Weeks
Status: TERMINATED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Topiramate|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CD19 Targeted CAR T Cell Therapy in Patients With Severe, Refractory Systemic Lupus Erythematosus (SLE)
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Obecabtagene autoleucel (obe-cel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TNF-alpha Directed Therapy in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Study drug administration|PROCEDURE: Tuberculin intradermal skin test|PROCEDURE: Lung function test for FEV1|PROCEDURE: Asthma symptom scores diary|PROCEDURE: Quality of life diary|PROCEDURE: Breath nitric oxide|PROCEDURE: Breath condensate|PROCEDURE: Sputum induction|PROCEDURE: Blood sampling|PROCEDURE: Urinalysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Coronary Drug Project Mortality Surveillance
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Infarction|Myocardial Ischemia
Interventions: DRUG: estrogen|DRUG: clofibrate|DRUG: dextrothyroxine sodium|DRUG: niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
Status: UNKNOWN
Conditions: Chronic Fatigue Syndrome|Myalgic Encephalomyelitis|Systemic Exertion Intolerance Disease (SEID)|Postural Tachycardia Syndrome (POTS)|Neurally Mediated Syncope (NMS)
Interventions: DRUG: Normal Saline|DIETARY_SUPPLEMENT: Oral Rehydration Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pelvic Autonomic Nerve Monitoring System (PAMS I) in Female Patients With Pelvic Tumors
Status: UNKNOWN
Conditions: Cervical Cancer|Uterine Cancer|Ovarian Cancer
Interventions: DEVICE: PAMS I
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effects Of A Probiotic Formulation On Stress and Skin Health in Younger Adult Females
Status: COMPLETED
Conditions: Stress|Skin Imperfections|Skin Fine Lines
Interventions: DIETARY_SUPPLEMENT: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer
Status: RECRUITING
Conditions: Hearing Loss|Head and Neck Cancer
Interventions: OTHER: Placebo|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pressure Garments on Hypertrophic Hand Scar in Burn Children
Status: COMPLETED
Conditions: Burns Laser
Interventions: OTHER: Low Level LASER Therapy with Pressure Garment|OTHER: Low Level LASER Therapy without Pressure Garment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Telemonitoring Study - for Chronic Myeloid Leukemia (CML)
Status: TERMINATED
Conditions: Chronic Myeloid Leukemia
Interventions: BEHAVIORAL: no access to eMedonline|BEHAVIORAL: eMedonline access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GDC-0853 in Healthy Japanese and Caucasian Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0853|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utilizing Transcranial Direct Current Stimulation to Enhance Laparoscopic Technical Skills Training
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Contribution of Melatonin Vs. Placebo in Benzodiazepine Withdrawal in Methadone Maintenance Treatment Patients
Status: UNKNOWN
Conditions: Benzodiazepines
Interventions: DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Xenogeneic HER2/Neu DNA Immunization for Patients With Metastatic and High Risk Breast Cancer: A Phase I Study to Assess Safety and Immunogenicity
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: BIOLOGICAL: MAB HER 2 (HERCEPTIN)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent OCT and FFR-guided PCI in CAD
Status: RECRUITING
Conditions: Coronary Artery Disease|Image|Atheroscleroses, Coronary
Interventions: DIAGNOSTIC_TEST: optical coherence tomography and fractional flow reserve|DIAGNOSTIC_TEST: Coronary angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-78278343 in Combination With Either JNJ-63723283 (Cetrelimab), Taxane Chemotherapy, or Androgen Receptor Pathway Inhibitors for Metastatic Castration-Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Neoplasms
Interventions: DRUG: JNJ-78278343|DRUG: Cetrelimab|DRUG: Cabazitaxel|DRUG: Docetaxel|DRUG: Apalutamide|DRUG: Enzalutamide|DRUG: Darolutamide|DRUG: Abiraterone acetate plus prednisone (AAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Candesartan Cilexetil / Hydrochlorothiazide Combination Tablets Special Drug Use Surveillance: Long-term Use (12 Months)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan cilexetil / hydrochlorothiazide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evidence of Spreading Vasoconstriction in Human Gingiva
Status: COMPLETED
Conditions: Vasoconstriction|Oral Soft Tissue Conditions|Dental and Gingival Conditions
Interventions: DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: GSK2190915 Safety and Pharmacokinetic Study in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GSK2190915|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tucatinib + Abemaciclib + Herceptin for HER2+ MBC
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Tucatinib|DRUG: Abemaciclib|DRUG: Trastuzumab|DRUG: Aromatase Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Inspiratory Muscle Training on Respiratory Functions and Exercise Capacity
Status: RECRUITING
Conditions: Ankylosing Spondylitis
Interventions: DEVICE: Inspiratory Muscle Trainer (IMT) (POWERbreathe Medic Classic)|OTHER: The Sample Spondylitis Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Extracoporeal Shock Wave Therapy (ESWT) for the Treatment of Detrusor Underactivity/ Underactive Bladder (DU/UAB)
Status: COMPLETED
Conditions: Detrusor, Underactive|Detrusor Underactivity
Interventions: DEVICE: Extracoporeal shock wave therapy|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of the Treatment of Allergy Against Cupressaceae and Grasses.
Status: RECRUITING
Conditions: Rhinitis, Allergic|Rhinoconjunctivitis|Asthma, Allergic
Interventions: BIOLOGICAL: 10,000 MG01 +10,000 T521|BIOLOGICAL: 30,000 MG01 +10,000 T521|OTHER: Placebo subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Nutraceutic Compound on Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Placebo oral vial|DRUG: Choline Bitartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of Two 0.25 mL or 0.5 mL Doses of Two Different Influenza Vaccines in Healthy Children Aged 6 to <60 Months
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Trivalent Inactivated vaccines Novartis|BIOLOGICAL: Influenza Trivalent Inactivated vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Randomized Controlled Trial of Multi-Source Feedback to Pediatric Residents
Status: COMPLETED
Conditions: Education, Medical|Education, Competency-Based|Feedback|Communication|Humanism
Interventions: BEHAVIORAL: Multi-Source Feedback: including self-assessment & coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: ECT
Clinical trial: Nursing Intervention to Reduce Incidence and Duration of Delirium in Patients in Intensive Care
Status: UNKNOWN
Conditions: Delirium
Interventions: BEHAVIORAL: Control|BEHAVIORAL: Interventions to reduce delirium based on DSM and scientific evidence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair
Status: RECRUITING
Conditions: Aneurysm, Intracranial
Interventions: DEVICE: Contour Neurovascular System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pleuropulmonary Ultrasound With Clinical Examination to Check the Good Position of the Double Lumen Tube Intubation
Status: COMPLETED
Conditions: Thoracic|Surgery
Interventions: DIAGNOSTIC_TEST: Pleuropulmonary ultrasound with clinical examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Range of Contact Lenses and Care System Combinations
Status: COMPLETED
Conditions: Contact Lens Solutions
Interventions: DEVICE: Hy-Care Contact Lens Solution|DEVICE: Lite Contact Lens Solution|DEVICE: fanfilcon A soft contact lens|DEVICE: comfilcon A soft contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: OTHER: Treatment As Usual|OTHER: CARIBOU-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI and Gene Expression in Diagnosing Patients With Ductal Breast Cancer In Situ
Status: ACTIVE_NOT_RECRUITING
Conditions: Ductal Breast Carcinoma In Situ
Interventions: PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Therapeutic Conventional Surgery|PROCEDURE: Therapeutic Surgical Procedure|RADIATION: Radiation Therapy|DRUG: Endocrine Therapy|OTHER: Quality-of-Life Assessment|OTHER: Laboratory Biomarker Analysis|OTHER: Cytology Specimen Collection Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain With Machine Learning to Predict Treatment Response
Status: RECRUITING
Conditions: Phantom Limb Pain
Interventions: DEVICE: M1 anodal home-based tDCS|BEHAVIORAL: Somatosensory Training|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carvedilol for Psychostimulant Dependence
Status: COMPLETED
Conditions: Cocaine Dependence|Cocaine Withdrawal
Interventions: DRUG: controlled release carvedilol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD19 and CD22 Targeted CAR-T Cell Therapy for Relapsed/Refractory B Cell Leukemia and Lymphoma
Status: RECRUITING
Conditions: Leukemia, B-cell|Lymphoma, B-Cell
Interventions: BIOLOGICAL: CD19 and CD22 targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effectiveness of SGB in Preventing Post-op Atrial Fibrillation
Status: WITHDRAWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Bupivacaine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the AB HiFocusTM Mid Scala Electrode Movement Using Cone Beam Imaging Following Cochlea Implantation
Status: UNKNOWN
Conditions: Cochlear Implantation|Cone-Beam Computed Tomography
Interventions: RADIATION: Cone Beam Computed Tomography (CBCT)|DEVICE: Magnetic Resonance Imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics of Metronidazole Dermal Products
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Metronidazole gel 1|DRUG: Metronidazole gel 2|DRUG: Metronidazole cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Saline Hypertonic in Preschoolers + CT
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Active Treatment Group 7% Hypertonic Saline|DRUG: Control Group 0.9% Isotonic Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study Evaluating CTX130 in Subjects With Relapsed or Refractory Renal Cell Carcinoma (COBALT-RCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: CTX130
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VB-111 in Combination With Nivolumab in People With Metastatic Colorectal Cancer (mCRC)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer|Colorectal Neoplasms|Colorectal Carcinoma|Colorectal Cancer With Hepatic Metastases|Colorectal Tumors
Interventions: BIOLOGICAL: Vascular Biogenics (VB)-111|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Moringa Oleifera on hsCRP and Hgba1c Level of Patients in Ospital ng Maynila Medical Center Diabetic Clinic
Status: COMPLETED
Conditions: Diabetes
Interventions: DIETARY_SUPPLEMENT: Moringa oleifera
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
Status: RECRUITING
Conditions: Wounds|Wound of Skin|Wound Leg|Wound; Foot|Diabetic Foot Ulcer|Venous Leg Ulcer
Interventions: DEVICE: Mepilex Up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing the Effectiveness of a Computer-based Program for Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Active computer-based training|BEHAVIORAL: Inert computer training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of CRD-740 in Heart Failure
Status: TERMINATED
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction|Heart Failure With Preserved Ejection Fraction|Cardiovascular Diseases|Heart Diseases
Interventions: DRUG: CRD-740|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Carboplatin and Vorinostat for the Treatment of Advanced Stage Ovarian Carcinoma
Status: TERMINATED
Conditions: Ovarian Neoplasms
Interventions: DRUG: Vorinostat|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma
Status: RECRUITING
Conditions: Metastatic Melanoma|Unresectable Melanoma|Acral Melanoma|Mucosal Melanoma|Cutaneous Melanoma|Ocular Melanoma|Uveal Melanoma|Iris Melanoma|Conjunctival Melanoma|Non-Cutaneous Melanoma
Interventions: BIOLOGICAL: TBio-4101|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma
Status: RECRUITING
Conditions: Clinical Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage IIIA Cutaneous Melanoma AJCC v8|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Interventions: DRUG: Atezolizumab|DRUG: Cobimetinib|BIOLOGICAL: Tiragolumab|DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous Membrane Pemphigoid
Status: UNKNOWN
Conditions: Severe Forms of Mucous Membrane Pemphigoid
Interventions: DRUG: Rituximab 1g IV|DRUG: Cyclophosphamide 50Mg Oral Tablet|DRUG: Placebo of Rituximab|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of the Two Alternative Sweeteners D-allulose and Erythritol on Metabolism
Status: COMPLETED
Conditions: Physiological Satiation Mechanisms
Interventions: DIETARY_SUPPLEMENT: Erythritol|DIETARY_SUPPLEMENT: Erythritol + lactisole|DIETARY_SUPPLEMENT: D-allulose|DIETARY_SUPPLEMENT: D-allulose + lactisole|DIETARY_SUPPLEMENT: Tap water|DIETARY_SUPPLEMENT: Tap water + lactisole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Itraconazole in Castrate-resistant Prostate Cancer (CRPC) Post-chemotherapy
Status: TERMINATED
Conditions: Prostate Cancer|Prostatic Neoplasms|Castrate-resistant Prostate Cancer (CRPC)|Androgen-insensitive Prostate Cancer|Hormone-refractory Prostate Cancer|Metastatic Disease
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methotrexate for Central Serous Chorioretinopathy Treatment Trial
Status: UNKNOWN
Conditions: Central Serous Chorioretinopathy
Interventions: DRUG: Methotrexate|DRUG: Delayed treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Radiation Therapy to Lungs in Moderate COVID-19 Pneumonitis: A Case-Control Pilot Study
Status: UNKNOWN
Conditions: COVID-19|Pneumonia
Interventions: RADIATION: Low dose radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: F01 in the Treatment of Moderate-to-severe Refractory Systemic Lupus Erythematosus
Status: NOT_YET_RECRUITING
Conditions: Lupus Erythematosis
Interventions: BIOLOGICAL: After preconditioning with chemotherapy, F01 will be evaluated.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension To The B1451027 Protocol To Evaluate The Long Term Safety And Tolerability Of Dimebon In Patients With Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Dimebon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison Study of Feeding Prematures in the Side-lying Position on the Right and Left Side - a Pilot Study.
Status: COMPLETED
Conditions: Bottle Feeding|Premature
Interventions: OTHER: Experimental SLP-R|OTHER: Experimental SLP-L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Tonsil Fossa Closure in Pain Relief After Tonsillectomy in Children
Status: UNKNOWN
Conditions: Tonsillitis
Interventions: PROCEDURE: Tonsillectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome
Status: TERMINATED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Sertraline|PROCEDURE: Bone Marrow Aspirate/Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of NX-1207 for the Treatment of Benign Prostatic Hyperplasia (BPH)
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: NX-1207|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study To Assess Efficacy, Safety and Tolerability Of PF-06700841 Topical Cream In Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: PF-06700841|DRUG: Vehicle (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: asenapine|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Somatostatin in Polycystic Kidney: a Long-term Three Year Follow up Study
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions: DRUG: Long-acting somatostatin|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Modified Process Hepatitis B Vaccine in Japanese Young Adults (V232-062)
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: 2XP HEPTAVAX™-II SC|BIOLOGICAL: 1XP HEPTAVAX™-II SC|BIOLOGICAL: 2XP HEPTAVAX™-II IM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mobility Training to Improve Motor Behavior in Toddlers With or at Risk for Cerebral Palsy: A Pilot Study
Status: COMPLETED
Conditions: Developmental Delay|Cerebral Palsy
Interventions: BEHAVIORAL: mobility training with dynamic body weight support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety of IDP-120 Gel in the Treatment of Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-120 Gel|DRUG: IDP-120 Component A|DRUG: IDP-120 Component B|DRUG: IDP-120 Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
Status: RECRUITING
Conditions: Voice Change|Hypocalcemia
Interventions: DRUG: Dexamethasone|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Post-marketing Surveillance Study on the Safety and Effectiveness of Abiraterone Acetate Among Adult Filipino Male Patients With Advanced Metastatic Castration Resistant Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Neoplasms
Interventions: DRUG: Abiraterone acetate|DRUG: Prednisone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study of Herzuma® Plus Gedatolisib in Patients With HER-2 Positive Metastatic Breast Cancer
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab biosimilars(Herzuma), Gedatolisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-guided Dose Reduction in Patients With Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Axillary Dissection Based on the Histological Result of the Sentinel Node, in Patients With Breast Carcinoma
Status: COMPLETED
Conditions: Breast Carcinoma
Interventions: PROCEDURE: quadrantectomy and axillary dissection|PROCEDURE: quadrantectomy + sentinel node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QVA Mechanistic Efficacy Study (Receptor Effects, Etc)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: QVA149|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: T3-T4 Gray Sympathycotomy Versus Ramicotomy for Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis|Compensatory Sweating|Compensatory Hyperhidrosis
Interventions: PROCEDURE: Ramicotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Patients With New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation
Status: NOT_YET_RECRUITING
Conditions: Left Bundle-Branch Block
Interventions: PROCEDURE: Transcatheter Aortic Valve Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biocollection in MyeloDysplastic Syndrome (P-MDS)
Status: RECRUITING
Conditions: Myelodysplastic Syndromes|Myelodysplastic Anemia|Myelodysplastic Syndrome With Isolated Del(5Q)|Myelodysplastic Syndrome With Ring Sideroblasts|Acute Myeloid Leukemia With Multilineage Dysplasia|Chromosome Abnormality
Interventions: OTHER: description of MDS pzatient cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase 1 Study to Evaluate the Safety of an Oral Biologic in Healthy Participants
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: MB-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Acute Voiding Difficulty After Radical Proctectomy
Status: COMPLETED
Conditions: Rectal Cancer|Urinary Retention
Interventions: DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise Training on Angiogenesis and Cachexia in Lung Cancer Patients
Status: COMPLETED
Conditions: Non-small-cell Lung Cancer
Interventions: BEHAVIORAL: Exercise training|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Activity of ORE1001 in Subjects With Ulcerative Colitis
Status: UNKNOWN
Conditions: Mild to Moderate Ulcerative Colitis
Interventions: DRUG: ORE1001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Proximal Hamstring Avulsion Clinical Trial - Operative or Nonoperative Treatment
Status: COMPLETED
Conditions: Hamstring Tendon Injury
Interventions: PROCEDURE: Surgical reattachment of hamstring tendons
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Persistence of Hepatitis B Antibody Levels & Immune Response to a Hepatitis B Vaccine Challenge
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B Kinder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Efficacy and Safety of Ceralasertib Plus Durvalumab in Participants Aged ≥ 18 Years With Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Progressed on or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic NSCLC
Interventions: DRUG: Ceralasertib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Response to Atropine Drops (RAD) Study
Status: COMPLETED
Conditions: Myopia
Interventions: DRUG: 0.01% atropine|DRUG: 0.05% atropine|DRUG: 0.05% atropine|DRUG: 0.05% atropine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: External Counterpulsation (ECP) for the Promotion of Collateral Growth in Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: ECP Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Re-differentiation of Radioiodine-Refractory BRAF V600E-mutant Papillary Thyroid Carcinoma With GSK2118436
Status: COMPLETED
Conditions: Papillary Thyroid Carcinoma
Interventions: DRUG: GSK2118436
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ESR-15-11293 - Saxa/Dapa, Safety and Efficacy Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Saxagliptin|DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)
Status: COMPLETED
Conditions: Nicotine Dependence|Smoking Cessation
Interventions: DEVICE: E-Cigarette 7.2 mg nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome
Status: ENROLLING_BY_INVITATION
Conditions: Hyperphagia in Prader-Willi Syndrome
Interventions: DRUG: Carbetocin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Astragalus Membranaceus on Aneurysmal Subarachnoid Hemorrhage
Status: UNKNOWN
Conditions: Aneurysmal Subarachnoid Hemorrhage
Interventions: DRUG: Astragalus Membranaceus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Ritalin on Postural Stability of Hyper Active Children
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Ritalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Mineral Density in Adults With Hyperphenylalaninemia on Kuvan Therapy
Status: TERMINATED
Conditions: Hyperphenylalaninemia|Phenylketonuria
Interventions: DRUG: Sapropterin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men and Women Who Are Either Between 18 - 45 Years or Between 65 - 80 Years to Test How Different Doses of BI 474121 Are Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 474121|DRUG: Midazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Diabetic Gastroparalysis: a Randomized Controlled Trial
Status: UNKNOWN
Conditions: Gastroparesis|Diabetes Complications
Interventions: OTHER: acupoints combination 1|OTHER: acupoints combination 2|OTHER: sham acupoints combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Bardoxolone Methyl in Patients With CKD at Risk of Rapid Progression (MERLIN)
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: DRUG: Bardoxolone methyl oral capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Icotinib as Adjuvant Therapy Compared With Standard Chemotherapy in Stage II-IIIA NSCLC With EGFR-mutation
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Icotinib|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Demonstrate The Bioequivalence Of Rosiglitazone XR (BRL-049653) 8mgs XR Manufactured At Two Different Sites.
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: RSG XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Non-instrumental Pleural Chest Physiotherapy
Status: RECRUITING
Conditions: Infectious Pleural Effusion
Interventions: OTHER: KRP-NI + KM|OTHER: KM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: How Important Is Acupressure Application in Balancing Heart Rate and Blood Pressure in the Treatment of Atrial Fibrillation? Single-Blind Randomized Experimental Study
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: How Important Is Acupress Applyıng In Atrıal Fıbrılatıon Treatment?
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability-Guided Exercise Training in Type 2 Diabetes
Status: WITHDRAWN
Conditions: Type 2 Diabetes|Diabetes Mellitus, Type 2|Type 2 Diabetes Mellitus in Obese
Interventions: OTHER: Aerobic exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Effectiveness and Manipulability Evaluation of a Domestic PD Machine
Status: COMPLETED
Conditions: Kidney Failure,Chronic
Interventions: DEVICE: FM peritoneal dialysis machine|DEVICE: HOMECHOICE peritoneal dialysis machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Histoacryl™ vs. Suture for Mesh Fixation in Lichtenstein Hernioplasty: A Randomized Prospective Double-Blinded Study
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Lichtenstein Hernioplasty with Histoacryl|PROCEDURE: Lichtenstein Hernioplasty with Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Pleural Effusions
Status: COMPLETED
Conditions: Malignant Pleural Effusions
Interventions: DRUG: SCB-313
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of SI-B001 in the Treatment of Recurrent and Metastatic HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: SI-B001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Hydrochloride Versus Imatinib Mesylate in Locally Advanced, Unresectable or Metastatic Chordoma
Status: UNKNOWN
Conditions: Effect of Drugs|Quality of Life|Chordoma|Advanced Cancer
Interventions: DRUG: Anlotinib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guadecitabine in Treating Patients With Higher-Risk Myelodysplastic Syndromes
Status: COMPLETED
Conditions: High Risk Myelodysplastic Syndrome
Interventions: DRUG: Guadecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Radiation Therapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|DRUG: carboplatin|DRUG: etoposide|DRUG: ifosfamide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Insulin Lispro Mix in Type 2 Diabetic Asian Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lispro Mix 50/50
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep, Mood, and Behavior Study
Status: COMPLETED
Conditions: Sleep Difficulties in Pediatric Anxiety Disorder|Generalized Anxiety Disorder|Separation Anxiety Disorder|Social Phobia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy-Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT