pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of BGB-A317 in Participants With Relapsed or Refractory Mature T- and NK-cell Neoplasms
Status: COMPLETED
Conditions: Peripheral T Cell Lymphoma|PTCL|Extranodal NK/T-cell Lymphoma|Extranodal NK/T-cell Lymphoma, Nasal Type|Extranodal NK T Cell Lymphoma|Extranodal NK T Cell Lymphoma, Nasal|Adult Nasal Type Extranodal NK/T-cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Angioimmunoblastic T-Cell Lymphoma Recurrent|Angioimmunoblastic T-Cell Lymphoma Refractory|Peripheral T-cell Lymphoma NOS|Peripheral T-Cell Lymphoma, Not Otherwise Specified|Peripheral T-Cell Lymphoma Refractory|Anaplastic Large Cell Lymphoma|Anaplastic Large Cell Lymphoma, ALK-Positive|Anaplastic Large Cell Lymphoma, ALK-negative|ALK-negative Anaplastic Large Cell Lymphoma|ALK-Positive Anaplastic Large Cell Lymphoma|Cutaneous T-cell Lymphoma
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Oshadi Icp In Patients With Type 1 Diabetes Mellitus - Phase Ib Clinical Study
Status: COMPLETED
Conditions: Diabetes Mellitus, Insulin-Dependent, 1
Interventions: DRUG: Oshadi Icp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Birth Outcomes in Bangladesh
Status: RECRUITING
Conditions: Birth Weight|Small for Gestational Age at Delivery|Diet; Deficiency|Gestational Weight Gain
Interventions: OTHER: Base cash transfer|BEHAVIORAL: Behavior change communication (BCC)|OTHER: Food basket|OTHER: Top-up cash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dasatinib in Combination With Chemotherapy for Relapsed or Refractory Core Binding Factor Acute Myeloid Leukemia
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Dasatinib|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Idarubicin|DRUG: Intrathecal (IT) cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The ADAPT Study: Use of Emtricitabine and Tenofovir Disoproxil Fumarate for Pre-Exposure Prophylaxis (PrEP)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Daily dosing|DRUG: Time-driven dosing|DRUG: Event-driven dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Estimate the Efficacy of Treatment With TNFi as Monotherapy or Combination Therapy With MTX and Compare and Contrast Efficacy With Tofacitinib as Monotherapy and Combination Therapy in a Real World Setting.
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: patterns of use of combination therapy and monotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chloroquine Phosphate Against Infection by the Novel Coronavirus SARS-CoV-2 (COVID-19): The HOPE Open-Label, Non Randomized Clinical Trial
Status: TERMINATED
Conditions: Pneumonia, Viral|Covid-19
Interventions: DRUG: UNIKINON (Chloroquine phosphate) 200mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LARC Forward Contraceptive Counseling at MHCC
Status: TERMINATED
Conditions: Contraception
Interventions: DRUG: Long Acting Reversible Contraception (LARC)|OTHER: Referral for Long Acting Reversible Contraception (LARC)|OTHER: Prescription for Short-Acting Hormonal Contraception
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Using the Speedometer During Colonoscopy
Status: UNKNOWN
Conditions: Colonic Polyp|Colonic Adenoma|Adenoma Colon
Interventions: DEVICE: Speedometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke (REVISE-1)
Status: COMPLETED
Conditions: Acute Stroke
Interventions: DEVICE: Remote ischemic conditioning|PROCEDURE: Endovascular treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Orthodontic Treatment on the Stability of Pre-Orthodontic Recession Coverage
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Connective Tissue Graft before Orthodontic treatment|PROCEDURE: Orthodontic treatment only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A VR Intervention for Promoting Prosocial Behavior and Well-being in Youth
Status: NOT_YET_RECRUITING
Conditions: Youth
Interventions: BEHAVIORAL: Prosocial VR intervention|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Tolerability, and Anti-Viral Effect of Locteron Compared to PEG-Intron in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: OTHER: Locteron (controlled-release interferon alpha 2b)|BIOLOGICAL: pegylated IFNa2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Term Effects of Anodal Cerebellar vs Anodal Cerebral Transcranial Direct Current Stimulation in Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Anodal tDCS cerebellar stimulation group|OTHER: Anodal tDCS cerebral (M1) stimulation group|OTHER: Sham Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Narrative Medicine for Improving Well-Being in Patients With Gastrointestinal Cancers
Status: RECRUITING
Conditions: Malignant Digestive System Neoplasm
Interventions: PROCEDURE: Discussion|OTHER: Interview|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety and Tolerability of Propionyl-L-Carnitine Hydrochloride in Patients With Mild Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Propionyl-L-Carnitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pregabalin on Pain Related to Walking in Patients With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy|Nerve Pain
Interventions: DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Prone Position Ventilation in Danish Patients With COVID-19 Induced Severe ARDS Treated With VV-ECMO
Status: COMPLETED
Conditions: ARDS, Human|Extracorporeal Membrane Oxygenation|COVID-19 Acute Respiratory Distress Syndrome|Prone Position|Adverse Event
Interventions: OTHER: Prone position ventilation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Peak Expiratory Flow Rate for Emergency Department Management of Acute Asthma Exacerbation
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Peak Expiratory Flow Rate (PEFR)|OTHER: Standard Clinical Judgement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Arteriosclerosis|Endothelial Function
Interventions: DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Celecoxib in Preventing Skin Cancer
Status: WITHDRAWN
Conditions: Non-melanomatous Skin Cancer
Interventions: DRUG: celecoxib|PROCEDURE: anti-cytokine therapy|PROCEDURE: antiangiogenesis therapy|PROCEDURE: biological therapy|PROCEDURE: cancer prevention intervention|PROCEDURE: chemoprevention of cancer|PROCEDURE: growth factor antagonist therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Status: RECRUITING
Conditions: Primary Brain Neoplasm
Interventions: DRUG: Hyperpolarized Carbon C 13 Pyruvate|PROCEDURE: Magnetic Resonance Spectroscopic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Daily Chlorexidine Bath for Health Care Associated Infection Prevention
Status: COMPLETED
Conditions: Health Care Associated Infection|Ventilator Associated Pneumonia|Central Line-associated Bloodstream Infection (CLABSI)|Catheter-Associated Urinary Tract Infection
Interventions: OTHER: 2% chlorhexidine digluconate solution with surface-active agents|OTHER: Usual Baths
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Digital Strategy-based Educational Skills Group for Secondary Students With Organization and Academic Motivation Challenges
Status: UNKNOWN
Conditions: ADHD
Interventions: BEHAVIORAL: BPT/OST|BEHAVIORAL: Peer Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Desmopressin on Nocturia in Obstructive Sleep Apnoea Patients
Status: TERMINATED
Conditions: Nocturia|Obstructive Sleep Apnoea
Interventions: DRUG: Desmopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Response to Immunotherapy Using Spliceosome Mutational Markers (PRISMM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Solid Tumor|SF3B1 Gene Mutation|Spliceosome Mutation|U2AF1 Gene Mutation|SRSF2 Gene Mutation
Interventions: OTHER: Recommendation for treatment with immunotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Program for the Identification of "Actionable" Atrial Fibrillation in the Family Practice Setting
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: 30 Second Pulse Check|DEVICE: Watch BP Home A|DEVICE: HeartCheck Hand-held ECG device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Men Engagement in Women Empowerment for Improving Maternal Mental Health Through Cash Transfer and Life Skills Building
Status: COMPLETED
Conditions: Empowerment|Domestic Violence|Depression|Self Efficacy
Interventions: BEHAVIORAL: Life Skills Building Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury
Status: TERMINATED
Conditions: Stomatitis
Interventions: DRUG: Etanercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of S-1 Plus DC-CIK for Patients With Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: BIOLOGICAL: DC-CIK|DRUG: S-1|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emotional Wellbeing in Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1|Diabetes|Depression|Anxiety|Distress, Emotional|Diabetes Distress|Loneliness|Social Functioning|Quality of Life
Interventions: DEVICE: COMPASS: digital CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cryocompression Therapy for Peripheral Neuropathy in Patients With Multiple Myeloma
Status: TERMINATED
Conditions: Chemotherapy-induced Peripheral Neuropathy|Plasma Cell Myeloma
Interventions: DEVICE: VascuTherm5 vascular compression device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate the Safety and Efficacy of Long-term Treatment With TEZ/IVA in CF Participants With an F508del CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: TEZ/IVA|DRUG: IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rolapitant Plus Olanzapine in Multiday Cisplatin Chemotherapy
Status: WITHDRAWN
Conditions: Germ Cell Tumor
Interventions: DRUG: Rolapitant|DRUG: Palonosetron|DRUG: Olanzapine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MEDI4736 Alone and in Combination With Tremelimumab or AZD9150 in Adult Subjects With Relapsed/Refractory DLBCL (D4190C00023)
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: MEDI4736|DRUG: tremelimumab|DRUG: AZD9150
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elimination of Microemboli During Aortic Valve Replacement
Status: UNKNOWN
Conditions: Neurocognitive Outcome After Aortic Valve Replacement
Interventions: PROCEDURE: Embol-X intra-aortic emboli filter|PROCEDURE: DBT dynamic bubble trap|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pragmatic Trial of Obsessive-compulsive Disorder
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Sertraline 200 milligram(mg)|DRUG: Sertraline 300 milligram(mg)|DRUG: Fluvoxamine|DRUG: Venlafaxine|DRUG: Augment with Memantine|DRUG: Augment with Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TAC T-cells for the Treatment of HER2-positive Solid Tumors
Status: TERMINATED
Conditions: HER2 Positive Gastric Cancer|Metastatic HER2 Positive Gastroesophageal Junction Cancer
Interventions: BIOLOGICAL: TAC01-HER2|BIOLOGICAL: TAC01-HER2 plus pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers
Status: RECRUITING
Conditions: Cigarette Smoking-Related Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|DIETARY_SUPPLEMENT: Broccoli Sprout/Broccoli Seed Extract Supplement|DRUG: Placebo Administration|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Ribociclib With Endocrine Therapy in Hormone Receptor+/HER2- High Risk Early Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Ribociclib|DRUG: Adjuvant endocrine therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Persistence of Immunity to Hepatitis B in Adults Vaccinated With GlaxoSmithKline (GSK) Biologicals' Hepatitis B Vaccine (HBV), Engerix-B
Status: COMPLETED
Conditions: Hepatitis B Vaccine
Interventions: BIOLOGICAL: Engerix-B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Bromodomain and Extra-Terminal Protein (BET) Inhibitor RO6870810 as Mono- and Combination Therapy in Advanced Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: RO6870810|BIOLOGICAL: daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryovagotomy Diabetes Trial
Status: COMPLETED
Conditions: Diabetes Type 2|Diabetes Mellitus|Obesity
Interventions: DEVICE: Cryoablation of the Vagus Nerve|BEHAVIORAL: Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The i-GelTM. A Randomized, Crossover Study With the Laryngeal Mask Airway ProSealTM in Anesthetized Pediatric Patients
Status: COMPLETED
Conditions: Device Success Rate|Device Performance
Interventions: DEVICE: i-Gel|DEVICE: ProSeal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exercise Training Following Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure
Status: COMPLETED
Conditions: Cardiac Resynchronization Therapy|Chronic Heart Failure
Interventions: BEHAVIORAL: Exercise training program|DEVICE: Cardiac resynchronization therapy (CRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy|Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy|Wild-Type Transthyretin Cardiac Amyloidosis
Interventions: BIOLOGICAL: NTLA-2001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Device Evaluation of Contak Renewal 2and Easytrak 2 - DECREASE-HF
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: DEVICE: CONTAK RENEWAL 2/4/4HE CRT-D|DEVICE: EASYTRAK 2 Lead
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment
Status: TERMINATED
Conditions: Non Alcoholic Steatohepatitis (NASH)
Interventions: DRUG: Obeticholic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ketamine|DRUG: Lidocaine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Empagliflozin vs Metformin in PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Empagliflozin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Roniciclib (BAY 1000394) Drug-Drug Interaction (DDI) Study
Status: COMPLETED
Conditions: Medical Oncology
Interventions: DRUG: Roniciclib (BAY 1000394)|DRUG: Itraconazole (Sporanox)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Investigating the Effect of Onyx Sorghum on Blood Glucose in Individuals With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DIETARY_SUPPLEMENT: onyx sorghum|DIETARY_SUPPLEMENT: whole wheat flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: 3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: triapine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Safety and Tolerability of Odronextamab in Patients With CD20+ B-Cell Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia
Interventions: DRUG: Odronextamab multiple dose levels|DRUG: Odronextamab multiple dose levels
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Bioequivalence of Two New Formulations of Premarin/MPA With Premarin/MPA Reference Formulation.
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis|Postmenopause
Interventions: DRUG: Formulations A and B of Premarin/MPA 0.45 mg/0.5 mg and PREMPRO0.45 mg/0.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clotrimazole vs. Mycelex® in Patients With Human Insufficiency Virus (HIV) Infection for the Treatment of Oropharyngeal Candidiasis
Status: COMPLETED
Conditions: Candidiasis, Oral
Interventions: DRUG: Roxanes's clotrimazole troches|DRUG: Mycelex® troches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infections
Status: COMPLETED
Conditions: Clostridium Difficile Infection (CDI)
Interventions: DRUG: Fidaxomicin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel as Salvage Treatment in Locally Advanced or Metastatic Gastric Cancer
Status: COMPLETED
Conditions: Stomach and Gastro-Esophageal Junction (GEJ) Cancer
Interventions: DRUG: nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)
Status: RECRUITING
Conditions: Hiv|Syphilis|HBV
Interventions: OTHER: TRI-MOM intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin glargine/lixisenatide fixed ratio combination|DRUG: liraglutide|DRUG: exenatide|DRUG: exenatide extended-release|DRUG: albiglutide|DRUG: dulaglutide|DRUG: Background therapy: Oral Anti-diabetic Drug (Metformin, Pioglitazone, SGLT2 inhibitor)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 32 Week, Open, Randomized, 2 Way Cross Over Multicentre Trial to Compare Safety & Efficacy of Combination of HOE901 Insulin Analogue Once Daily at Bedtime + Lispro Insulin Before Meals vs NPH Insulin (Twice a Day) + Regular in Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy
Interventions: OTHER: gait recordings|OTHER: brain magnetic resonance imaging|OTHER: oculomotor movement recordings
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Toric IOL vs Non-toric IOL With LRI for Corneal Astigmatism
Status: UNKNOWN
Conditions: Corneal Astigmatism
Interventions: DEVICE: Toric intraocular MX60T lens|OTHER: Standard MX60 plus corneal incisions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Oral Nutrition Intervention for Patients Undergoing Radical Cystectomy
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DIETARY_SUPPLEMENT: Ensure Plus®|DIETARY_SUPPLEMENT: Multivitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Influence of Protein Hydrolysis on Dietary Protein Digestibility and Metabolism in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Intestinal and metabolic exploration|DIETARY_SUPPLEMENT: 15N-labelled intact casein|DIETARY_SUPPLEMENT: 15N-labelled hydrolyzed casein|DIETARY_SUPPLEMENT: mixture of AA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose:
Clinical trial: EndoSearch : Endometriosis Biomarkers
Status: UNKNOWN
Conditions: Endometriosis (Diagnosis)|Blood Biomarkers|Endometrium Biomarkers
Interventions: OTHER: Assessment of endometrium and blood biomarkers for endometriosis diagnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Nicotinic Agonist Treatment Trial for Autism
Status: TERMINATED
Conditions: Autism
Interventions: DRUG: DMXB-A 150 mg|OTHER: placebo|DRUG: DMXB-A 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement
Status: TERMINATED
Conditions: Osteoarthritis|Post-traumatic Arthritis|Collagen Disorder|Avascular Necrosis|Traumatic Femoral Fractures|Nonunion of Femoral Fractures|Congenital Hip Dysplasia|Slipped Capital Femoral Epiphysis
Interventions: DEVICE: Ultima LX Collared Stem - Non-Polished/Blasted Finished|DEVICE: Ultima LX Collared Stem - Polished Finished|DEVICE: Ultima LX Collarless Stem - Non-Polished/Blasted Finished|DEVICE: Ultima LX Collarless Stem - Polished finished
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Light Therapy in Treatment of Chronic Cluster Headache
Status: NOT_YET_RECRUITING
Conditions: Cluster Headache
Interventions: OTHER: use of Luminettes ® with active light emission|OTHER: use of Luminettes ® with a light emission presumed to have no therapeutic effect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neodymium-doped Yttrium Aluminum Garnet (Nd:YAG) Laser Treatment for Granular Corneal Dystrophy
Status: RECRUITING
Conditions: Granular Dystrophy, Corneal
Interventions: DEVICE: Nd:YAG Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Placebo-Controlled, Double-Blind Comparative Study of E2080 in Lennox-Gastaut Syndrome Patients (Study E2080-J081-304)
Status: COMPLETED
Conditions: Lennox-Gastaut Syndrome
Interventions: DRUG: Rufinamide (E2080)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Chloral Hydrate for Pediatric Sedation During EEG
Status: WITHDRAWN
Conditions: Procedural Sedation
Interventions: DRUG: Dexmedetomidine|DRUG: Chloral hydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RCT on the Combined Modality Treatment of Squamous Cell Carcinoma of the Esophagus
Status: TERMINATED
Conditions: Esophageal Neoplasms|Squamous Cell Cancer
Interventions: PROCEDURE: transthoracic esophagectomy 2-field extended lymphadenectomy|DRUG: neoadjuvant chemotherapy (cisplatin, 5-fluorouracil)|RADIATION: neoadjuvant chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic And Pharmacodynamic Study Of A Single-Dose Of PF-04950615 (RN316) In Combination With Atorvastatin
Status: COMPLETED
Conditions: Hypercholesterolemia|Dyslipidemia
Interventions: BIOLOGICAL: 4 mg/kg|BIOLOGICAL: 0.5 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adults With Diabetic Gastroparesis
Status: RECRUITING
Conditions: Diabetic Gastroparesis
Interventions: DRUG: CIN-102 Dose 1|DRUG: CIN-102 Dose 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Substrate of Patients With Myocardial Infarction With and Without Modifiable Cardiovascular Risk Factors
Status: WITHDRAWN
Conditions: Cardiovascular Diseases|Acute Myocardial Infarction|Acute Coronary Syndrome|Metabolic Disturbance
Interventions: DIAGNOSTIC_TEST: Investigation of the metabolic substrate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Evaluation of Octreotide in the Treatment of Congenital Hyperinsulinemia
Status: COMPLETED
Conditions: Congenital Hyperinsulinaemic Hypoglycaemia|Octreotide Adverse Reaction
Interventions: DRUG: Octreotide Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Neoplasms
Interventions: DRUG: tucatinib|DRUG: trastuzumab|DRUG: bevacizumab|DRUG: cetuximab|DRUG: oxaliplatin|DRUG: leucovorin|DRUG: levoleucovorin|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niclosamide for Familial Adenomatous Polyposis
Status: UNKNOWN
Conditions: Familial Adenomatous Polyposis
Interventions: DRUG: Niclosamide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive TMS of the Default Mode Network in AD
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients
Status: WITHDRAWN
Conditions: Pain Intractable|Delirium|Dyspnea|Nausea
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
Status: COMPLETED
Conditions: Lumbar Osteoarthritis|Spondylosis|Lumbar Disc Disease|Spinal Stenosis
Interventions: DRUG: Ketorolac|DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Everolimus Alone or in Combination With Pasireotide LAR in Advanced PNET
Status: TERMINATED
Conditions: Islet Cell Tumor
Interventions: DRUG: Everolimus|DRUG: Pasireotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HX008 Plus Irinotecan Versus Placebo Plus Irinotecan as Second-line Treatment in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Cancer
Interventions: DRUG: Irinotecan Hydrochloride Injection|DRUG: HX008|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Metformin Plus Paclitaxel/Carboplatin/Bevacizumab in Patients With Adenocarcinoma.
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Adenocarcinoma
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Bevacizumab|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using NICU Discharge Education Tools to Enhance Discharge Preparation for Parents of Moderate to Late Preterm Infants
Status: ENROLLING_BY_INVITATION
Conditions: Discharge Readiness
Interventions: OTHER: NICU Discharge Passport|OTHER: NICU Infant Care Class
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Prostate Adenocarcinoma|Prostate Adenocarcinoma With Focal Neuroendocrine Differentiation|Recurrent Prostate Carcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: DRUG: Abiraterone Acetate|DRUG: Apalutamide|DRUG: Leuprolide Acetate|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alpha-type-1 Dendritic Cell-based Vaccines in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: DC-based vaccine|BIOLOGICAL: DC-based vaccine|BIOLOGICAL: DC-based vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Belimumab Impacting Transplant Eligibility
Status: COMPLETED
Conditions: Renal Transplant Rejection
Interventions: DRUG: belimumab|DRUG: Bortezomib|DRUG: Rituximab|DRUG: Plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Stage-Based Tailored, Nutrition Education Package for Childhood Obesity (ST-NEPCO) (7-12 Years Old)
Status: UNKNOWN
Conditions: Educational Materials (ST-NEPCO) During Nutrition Counselling for Obese Children
Interventions: BEHAVIORAL: Lifestyle modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate and Cognitive Training in Elderly
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Methylphenidate|DRUG: Placebo|OTHER: CogniPlus software|OTHER: Pseudo cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study With Intranasal Kinetic Oscillation Stimulation (KOS) in the Prevention of Chronic Migraine
Status: RECRUITING
Conditions: Chronic Migraine
Interventions: DEVICE: KOS (Intranasal kinetic oscillation stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion
Status: COMPLETED
Conditions: Symptomatic Vitreomacular Adhesion
Interventions: DRUG: Ocriplasmin|DRUG: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The PrEPARE Project: Prevention, Empowering, and Protecting Young Women in South Africa
Status: COMPLETED
Conditions: HIV Prevention
Interventions: BEHAVIORAL: Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum|BEHAVIORAL: Young Women's Health CoOp (YWHC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HPV Prevalence in Transpersons - a Prospective Study
Status: COMPLETED
Conditions: Papillomavirus Infection|Transsexualism
Interventions: DIAGNOSTIC_TEST: Colli-Pee urine collection device|OTHER: Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of C2L-OCT-01 PR in Acromegalic Patients
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: C2L-OCT-01 PR, 30 mg|DRUG: Octreotide acetate prolonged release, 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System
Status: RECRUITING
Conditions: Recurrent Prostate Cancer
Interventions: DRUG: Verteporfin|DEVICE: SpectraCure P18 System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TacTIC- Trans-disciplinary Chronic Disease Continuity of Care Model
Status: WITHDRAWN
Conditions: Chronic Disease|Geriatrics
Interventions: BEHAVIORAL: TacTic care model|BEHAVIORAL: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Multiple Gingival Recessions With a MCAF or a MCAT and a Collagen Matrix
Status: ACTIVE_NOT_RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: MCAF+CM|PROCEDURE: MCAT+CM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adverse Neonatal Outcomes With a Shortened Clinical Regimen of Dexamethasone.
Status: RECRUITING
Conditions: Preterm Birth|Distress Respiratory Syndrome
Interventions: DRUG: Dexamethasone 12 mg QD|DRUG: Dexamethasone 6 mg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant
Status: UNKNOWN
Conditions: Acromegaly|Heart Failure|Hypertrophy, Left Ventricular
Interventions: DRUG: pegvisomant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prismatic Lenses and tDCS in Neglect
Status: RECRUITING
Conditions: Stroke, Ischemic
Interventions: COMBINATION_PRODUCT: Prismatic adaptation and electric stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact on Survival of Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Hepatocellular Carcinoma And Portal Vein Tumor Thrombosis (PVTT) Who Underwent Hepatectomy : A Random, Controlled, Stage III Clinical Trial.
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TAI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block vs Tranversus Abdominis Plane Block for Cesarean Section
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Quadratus Lumborum block|PROCEDURE: Tranversus Abdominis plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Granisetron Hydrochloride Nasal Spray (GNS) in Healthy Volunteers
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: GNS Spray 0.5mg|DRUG: GNS Spray 1.0mg|DRUG: GNS Spray 2.0mg|DRUG: Kytril 1mg (IV injection)|DRUG: Kytril 1mg (Tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Recovery With Liposomal Bupivacaine in Orthognathic Surgery
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Liposomal Bupivacaine|DRUG: Bupivacaine and Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3885125 in Participants With Dyslipidemia or Non-Alcoholic Fatty Liver Disease (NAFLD)
Status: RECRUITING
Conditions: Dyslipidemias|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: LY3885125|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Innovative Approach to Automated Carbon Dioxide Angiography During Endovascular Abdominal Aortic Aneurysm Repair
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Endovascular Aortic Repair using Carbon Dioxide Angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of LY2605541 in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2605541|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Renal Effect of Dipeptidyl-peptidase 4 Inhibitors and Sulfonylureas
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Proteinuria
Interventions: DRUG: Dipeptidyl Peptidase 4 Inhibitor|DRUG: Sulfonylurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Interaction Study of Ketoconazole/Verapamil Versus AZD1305
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ketoconazole|DRUG: Verapamil|DRUG: AZD1305
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Vitamin C in Assessing the Severity of Oral Mucositis in Chemoradiation of Head and Neck Cancers
Status: COMPLETED
Conditions: Oral Mucositis
Interventions: DRUG: Ascorbic Acid|DRUG: Zinc acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clofarabine in Treating Patients With T-Cell or Natural Killer-Cell Non-Hodgkin's Lymphoma That Has Relapsed or Not Responded to Previous Treatment
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Small Intestine Cancer
Interventions: DRUG: clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Values of PET Examination With 11 C-Fe_CIT With Voxel-based Analysis Method in Patients With Sporadic Parkonson's Disease and Parkinsonisms (Prot.PD-diagn).
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DIAGNOSTIC_TEST: PET with 11C-Fe-CIT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase Ib/II Study of PLX 3397 and Eribulin in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: PLX3397|DRUG: Eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of WX-037 Alone and in Combination With WX-554 in Solid Tumours
Status: TERMINATED
Conditions: Advanced Solid Tumours
Interventions: DRUG: WX-037|DRUG: WX-554
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Adoport® (Tacrolimus) in Patients With de Novo Kidney Transplantation
Status: COMPLETED
Conditions: Transplantation|Kidney|Pharmacokinetic
Interventions: DRUG: Tacrolimus monohydrate (ADOPORT®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER