pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder
Status: WITHDRAWN
Conditions: Bipolar Affective Disorder|Depression
Interventions: DRUG: Coenzyme Q10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations
Status: COMPLETED
Conditions: Non-small Cell Lung Carcinoma|Urothelial Carcinoma|Gastrointestinal Carcinoma, Non-colon|Upper Aerodigestive Tract Carcinoma
Interventions: DRUG: Afatinib|DRUG: Regorafenib|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial in Healthy Female Subjects to Compare the Pharmacokinetics of Ethinyl Estradiol of NuvaRing®, a Contraceptive Patch (EVRA(TM)) and an Oral Contraceptive (Microgynon® 30) (Study 34237 (P06650)) (COMPLETED)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Levonorgestrel (LNG)/Ethinylestradiol (EE) oral contraceptive tablets|DRUG: norelgestrominum and ethinylestradiol patch oral contraceptive patch|DRUG: Nuvaring ™ (etonorgestrel/ethinylestradiol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of the Usefulness of Omega 3 Vitamins in the Relief of Hot Flashes in Menopausal Women.
Status: COMPLETED
Conditions: Hot Flashes|Menopause
Interventions: DIETARY_SUPPLEMENT: Omega 3 fatty acid vitamins|DIETARY_SUPPLEMENT: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Concentration Impact Nicotine Salt
Status: RECRUITING
Conditions: Smoking Cessation|Vaping
Interventions: PROCEDURE: Smoking cessation counseling|OTHER: Open system vape device and nicotine salt e-liquids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low Dose Melphalan and Bortezomib for AML and High-Risk MDS
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Melphalan|DRUG: Bortezomib|DRUG: Melphalan and bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Central Venous Oxygen Saturation Measurements by Non-invasive Mespere Venous Oximeter and Central Venous Catheter
Status: UNKNOWN
Conditions: Sepsis|Post Cardiac Surgery Low Output Syndrome Requiring Inotropic/Vasopressor Therapy|Cardiogenic Shock Post Myocardial Infarction|Hypoxemic Respiratory Failure.
Interventions: DEVICE: Mespere Venous Oximeter|DEVICE: Co-Oximeter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Focal Laser Ablation for the Treatment of Focal Low-Intermediate Risk Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DEVICE: Procedure/Surgery: Transperineal Focal Laser Ablation (TPLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: LY500307 150mg|DRUG: LY500307 75mg|DRUG: Placebo|DRUG: LY500307 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Capecitabine and Weekly Docetaxel Followed by Capecitabine Maintenance for Patients With Metastatic Breast Carcinoma
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: docetaxel and capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Escalating Doses of LEO 43204 Applied Once Daily for Two Consecutive Days on Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LEO 43204|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Effects of a Herbal Drug Compared to Placebo on Sleep
Status: COMPLETED
Conditions: Healthy|Sleep Quality
Interventions: DRUG: Neurapas® balance (Herbal product (Hypericum, Passionflower, Valerian))|DRUG: film-coated sugar-pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Denosumab in Combination With Immune Checkpoint Inhibitors in Patients With Unresectable or Metastatic Melanoma
Status: UNKNOWN
Conditions: Melanoma Stage Iv|Melanoma Stage Iii|Melanoma
Interventions: DRUG: Denosumab|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Gait Automaticity in Older Adults by Exploiting Locomotor Adaptation
Status: RECRUITING
Conditions: Community Mobility of Older Adults|Locomotor Adaptability|Gait Automaticity
Interventions: OTHER: Split-belt walking|OTHER: Multiple transitions between split-belt and tied-belt walking
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of Cellular Proliferation in Tumors by Positron Emission Tomography (PET) Using [18F]ISO-1
Status: COMPLETED
Conditions: Breast Cancer|Head and Neck Cancer|Diffuse Large B-cell Lymphoma
Interventions: RADIATION: PET/CT|OTHER: Laboratory Testing|OTHER: Safety Testing|OTHER: Immunohistochemistry staining|DRUG: F-18-ISO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Automatic Testing Feature in New ICDs and CRT-Ds
Status: COMPLETED
Conditions: Heart Failure|Ventricular Arrythmias
Interventions: DEVICE: Testing of the autocapture features of the device|DEVICE: Testing of the autocapture features of the device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Sequential & Concurrent CarboTaxol + Radiotherapy for High Risk Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Carboplatin and Paclitaxel|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goal Management Training for Adult Survivors of Childhood Leukemia and Non-Hodgkins Lymphoma With Neurocognitive Sequelae
Status: ACTIVE_NOT_RECRUITING
Conditions: Childhood Non-Hodgkin Lymphoma|Childhood Acute Lymphoblastic Leukemia|Childhood Acute Myeloid Leukemia
Interventions: BEHAVIORAL: Goal Management Training (GMT)|BEHAVIORAL: Brain Health Workshop (BHW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy of Afatinib in the Treatment of Locally Advanced/Metastatic Non-Small Cell Lung Cancer With NRG1 Fusion
Status: UNKNOWN
Conditions: NRG1-fused Non-small Cell Lung Cancer
Interventions: DRUG: Afatinib Dimaleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of SHR-1819 Injection in Adult Patients With Severe Atopic Dermatitis
Status: NOT_YET_RECRUITING
Conditions: Moderate to Severe Atopic Dermatitis
Interventions: DRUG: SHR-1819|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Topical Twice Weekly Fluticasone Treatment to Reduce Relapse in Atopic Dermatitis in Children
Status: TERMINATED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Fluticasone, cream|DRUG: Placebo,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Trial of Alprazolam 0.25 mg Tablets
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: Alprazolam 0.25 mg|DRUG: Alprazolam 0.25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Presentation of Lumbar Disc and Reduction of Symptoms
Status: COMPLETED
Conditions: Radiculopathy
Interventions: BEHAVIORAL: Presentation of excised intervertebral disc fragments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topical Tazarotene Vs Placebo In Hand-Foot-Skin Reactions
Status: TERMINATED
Conditions: Solid Tumor|Hand-Foot Skin Reaction (HFSR)
Interventions: DRUG: Topical Tazarotene|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in Patients With Intermittent Claudication
Status: COMPLETED
Conditions: Intermittent Claudication|Peripheral Vascular Disease
Interventions: DRUG: Niacin Extended Release and Lovastatin Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Ventilation Versus Sham Ventilation in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Hypercapnic Respiratory Failure|Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Home non-invasive ventilation|DEVICE: Home non-invasive ventilation (sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiosurgery in Treating Patients With Liver Metastases, Lung Metastases, or Other Advanced Solid Tumors
Status: COMPLETED
Conditions: Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEAK PlasmaBlade TnA Versus Traditional Electrosurgery in Subcapsular Tonsillectomy
Status: TERMINATED
Conditions: Tonsillitis
Interventions: DEVICE: PEAK PlasmaBlade TnA|DEVICE: Traditional Electrosurgery with scalpel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Perifosine in Patients With Relapsed/Refractory Waldenstrom's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: Perifosine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Cyclosporine Ophthalmic Emulsion in Patients With Primary Pterygium
Status: COMPLETED
Conditions: Pterygium
Interventions: DRUG: cyclosporine ophthalmic emulsion 0.05%|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide
Status: COMPLETED
Conditions: CYSTOID MACULAR EDEMA
Interventions: DRUG: Ranibizumab,|DRUG: Triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Increased Protein Density Diet to Muscle Mass and Strength Among Mid-aged and Older Adults
Status: COMPLETED
Conditions: Muscle Loss|Muscle Weakness|Fragility
Interventions: DIETARY_SUPPLEMENT: 25% protein|DIETARY_SUPPLEMENT: 15% protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Intrathecal Oxytocin in Patients With Neuropathic Pain
Status: TERMINATED
Conditions: Neuropathic Pain
Interventions: DRUG: oxytocin 100 micrograms|DRUG: Normal Saline (preservative free)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PSMA-Guided Ablation of the Prostate
Status: RECRUITING
Conditions: Prostate Cancer|Localized Prostate Carcinoma
Interventions: DIAGNOSTIC_TEST: PSMA-1007 Positron Emission Tomography (PET) scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Implant Placement in Mandibular Molar Xenograft Versus PRF
Status: UNKNOWN
Conditions: Edentulous Alveolar Ridge
Interventions: PROCEDURE: extraction,implant placement,PRF|PROCEDURE: Exctraction,Implant placement,Bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose Response of a Tubule Occlusion Agent
Status: COMPLETED
Conditions: Dentine Hypersensitivity|Dental Pain
Interventions: DEVICE: 5% calcium sodium phosphosilicate toothpaste|DEVICE: 7.5% calcium sodium phosphosilicate toothpaste|DEVICE: Placebo toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid for Preventing Postpartum Haemorrhage Following a Vaginal Delivery
Status: COMPLETED
Conditions: Immediate Postpartum Hemorrhage
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hyaluronic Acid and Adelmidrol (Hyadrol®) in Patients With Degenerative Joint Disease
Status: RECRUITING
Conditions: Degenerative Joint Disease
Interventions: DEVICE: Hyadrol®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Ultrasound Guided Serratus Anterior Plane Block and Pectoral Nerve Block II
Status: RECRUITING
Conditions: Anesthesia|Radical Mastectomy
Interventions: PROCEDURE: Anethesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Therapy to Antibiotics in the Treatment of S. Aureus Ventilator-Associated Pneumonia With AR-301
Status: COMPLETED
Conditions: Lung Infection|Pneumonia, Ventilator-Associated|Infection, Bacterial|Staphylococcus Aureus
Interventions: DRUG: AR-301|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intradialytic Parenteral Nutrition in Hemodialysis Patients
Status: COMPLETED
Conditions: Malnutrition|Complication of Hemodialysis
Interventions: DRUG: Intradialytic Parenteral Nutrition (IDPN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Electrical Impedance Myography (EIM) as a Potential Biomarker of Idiopathic Inflammatory Myopathies
Status: COMPLETED
Conditions: Idiopathic Inflammatory Myopathies
Interventions: DEVICE: electrical impedance myography|OTHER: healthy control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: INtracorporeal Versus EXTracorpoREal anastoMOsis After Laparoscopic Right Colectomy for Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Laparoscopic right hemicolectomy for cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of MAGE-A3 + AS-15 in Patients With Muscle-invasive Bladder Cancer After Cystectomy
Status: TERMINATED
Conditions: Urinary Bladder Neoplasms
Interventions: BIOLOGICAL: recMAGE-A3 + AS15 ASCI|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mechanical Nerve Stimulation in the Treatment of Post Prostatectomy Incontinence
Status: UNKNOWN
Conditions: Urinary Incontinence|Radical Prostatectomy
Interventions: DEVICE: Transcutaneous mechanical nerve stimulation (TMNS) (FERTI CARE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the C3 Inhibitor AMY-101 in Patients With ARDS Due to COVID-19 (SAVE)
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome Due to SARS-CoV-2 Infection (Severe COVID19)
Interventions: DRUG: AMY-101|OTHER: WFI 5% glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Epigallocatechin Gallate and Other Antural Compounds in HPV Infections
Status: COMPLETED
Conditions: Papilloma-induced Cervical Lesions
Interventions: DRUG: EGCG, FA, HA, B12
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ThermoDox With Standardized Radiofrequency Ablation (RFA) for Treatment of Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: ThermoDox|DRUG: Dummy infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ulinastatin on the Action of NDMRs (Rocuronium / Cisatracurium)
Status: NOT_YET_RECRUITING
Conditions: Nondepolarising Muscle Relaxants
Interventions: DRUG: Ulinastatin|PROCEDURE: TOF monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Korean Hand Acupressure on Postoperative Nausea-Vomiting and Retching After Thyroidectomy
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: OTHER: Korean hand acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
Status: RECRUITING
Conditions: Autonomous Cortisol Secretion|Adrenal Incidentaloma|Non-functioning Adrenal Adenomas
Interventions: BEHAVIORAL: Cognitive function assessment; functional magnetic resonance imaging|PROCEDURE: laparoscopic adrenal surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bicarbonate in Cardiac Surgery
Status: TERMINATED
Conditions: Acute Kidney Injury
Interventions: DRUG: Sodium Bicarbonate|DRUG: Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Tcm Cells Immunotherapy in Patients With Non-Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Autologous Tcm cells immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistent Pulmonary Hypertension of the Newborn
Status: TERMINATED
Conditions: Persistent Pulmonary Hypertension of the Newborn
Interventions: DRUG: Bosentan|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Broccoli Supplement Dose Response
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Avmacol tablets|DIETARY_SUPPLEMENT: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study of SUNITINIB and Rapamycin in Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: sunitinib and rapamycin (Drug will be held)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Beetroot Juice on Racial Disparities in Vascular Health
Status: COMPLETED
Conditions: Blood Pressure|Racial Disparities|Cardiovascular Risk Factor
Interventions: OTHER: Acute Beetroot Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sequential Treatment of Postmenopausal Women With Primary Osteoporosis (FP-001-IM)
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Parathyroid Hormone (PTH)|DRUG: Risedronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab in Treating Patients With Previously Treated, Locally Advanced, or Metastatic Cancer of the Urothelium
Status: TERMINATED
Conditions: Distal Urethral Cancer|Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter|Proximal Urethral Cancer|Recurrent Bladder Cancer|Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter|Recurrent Urethral Cancer|Stage IV Bladder Cancer|Transitional Cell Carcinoma of the Bladder|Urethral Cancer Associated With Invasive Bladder Cancer
Interventions: BIOLOGICAL: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Complete Lower Dentures on 1 or 2 Implants
Status: ACTIVE_NOT_RECRUITING
Conditions: Tooth-loss|Edentulous Mouth|Complete Denture|Complete Lower Denture
Interventions: PROCEDURE: 1 implant placed surgically in the mandibular midline|PROCEDURE: 2 implants placed surgically in the mandibular canine sites|PROCEDURE: Soft reline (Coe Comfort) of the existing complete lower denture|DEVICE: 2.25mm ball patrix placed on 1 healed implant|DEVICE: 2.25mm ball patrices placed on 2 healed implants|PROCEDURE: Reline (Ivoclar acrylic-resin) with 1 retentive matrix in the lower denture|PROCEDURE: Reline (Ivoclar acrylic-resin) with 2 retentive matrices in the lower denture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
Status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes|Heart Failure
Interventions: DRUG: Sotagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Unilateral Versus Bilateral Intensive Training in Children With Cerebral Palsy
Status: RECRUITING
Conditions: Cerebral Palsy
Interventions: OTHER: unilateral upper limbs intensive training|OTHER: bilateral upper limbs intensive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014)
Status: RECRUITING
Conditions: Metastatic Esophageal Squamous Cell Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib|DRUG: Cisplatin|DRUG: 5-FU|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Levoleucovorin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Celecoxib|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hemodynamics in Chronic Hemodialysis Patients Undergoing Isolated Ultrafiltration Compared to Conventional Hemodialysis
Status: RECRUITING
Conditions: End Stage Kidney Disease
Interventions: PROCEDURE: isolated Ultrafiltration (iso-UF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo.
Status: UNKNOWN
Conditions: Wound|Anesthesia, Local
Interventions: DRUG: Lidocaine|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ECRB Tendinopathy: Needling ± PRP After Failure of Rehabilitation
Status: UNKNOWN
Conditions: Tennis Elbow|PRP|Tendinopathy|Tendinosis|Extracorporal Shockwave Therapy (ESWT)|Tendon Needling (Peppering)|Extensor Carpi Radialis Brevis (ECRB)
Interventions: OTHER: Initial rehabilitation protocol|PROCEDURE: Needling with PRP|PROCEDURE: Needling with saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS to Enhance Cognitive Training in Multiple Sclerosis
Status: WITHDRAWN
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DEVICE: Real tDCS + CCT|DEVICE: Sham tDCS + CCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Islatravir in Participants With Severe Renal Impairment (MK-8591-026)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV) Infection
Interventions: DRUG: Islatravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ATRA Plus G-CSF for Mobilization of Hematopoietic Stem and Progenitor Cells
Status: COMPLETED
Conditions: Multiple Myeloma|Cutaneous Lymphoma
Interventions: DRUG: ATRA plus G-CSF (filgrastim, NEUPOGEN (R)) combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Neural and Behavioral Therapies to Enhance Stroke Recovery
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: Real rTMS|PROCEDURE: Sham rTMS|PROCEDURE: Unimanual paretic UE Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Oral Hydroxyurea Solution
Status: COMPLETED
Conditions: Sickle Cell Disease|Sickle-Cell; Hemoglobin Disease, Thalassemia|Sickle Cell-beta-thalassemia|Sickle Cell Hemoglobin C
Interventions: DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Lornoxicam Infusion for Orthopaedic Surgery
Status: SUSPENDED
Conditions: Closed Non Comminuted Long Bone Fractures
Interventions: DRUG: Placebo|DRUG: Continuous infusion|DRUG: Scheduled
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of TAK-079 in Healthy Participants
Status: COMPLETED
Conditions: Autoimmune Disease
Interventions: DRUG: TAK-079|DRUG: Placebo to TAK-079
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Doses of Neural Stem Cell Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas
Status: RECRUITING
Conditions: Recurrent Anaplastic Astrocytoma|Recurrent Anaplastic Oligoastrocytoma|Recurrent Anaplastic Oligodendroglioma|Recurrent Glioblastoma|Recurrent Gliosarcoma|Recurrent Malignant Glioma|Recurrent WHO Grade II Glioma|Recurrent WHO Grade III Glioma
Interventions: BIOLOGICAL: Neural Stem Cells-expressing CRAd-S-pk7|PROCEDURE: Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Raltegravir + Lopinavir/Ritonavir Versus Efavirenz + Tenofovir + Emtricitabine in Treatment Naive Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Kaletra + Isentress|DRUG: Atripla
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Fomivirsen sodium|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hysteroscopy With Fundus Uterus Scratching Incision VS Office Hysteroscopy Before ET With Donor Eggs
Status: UNKNOWN
Conditions: Hysteroscopy, Oocyte Recipients
Interventions: PROCEDURE: Uterine fundus endometrial incision during hysteroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of CKDB-501A in Subjects With Moderate-to-severe Glabellar Lines in Phase 3 Trial
Status: COMPLETED
Conditions: Glabellar Lines
Interventions: DRUG: CKDB-501A|DRUG: Botox®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation for the Treatment of Benign or Low Risk Thyroid Nodule
Status: RECRUITING
Conditions: Benign Thyroid Gland Neoplasm|Recurrent Thyroid Gland Carcinoma|Thyroid Gland Follicular Tumor of Uncertain Malignant Potential|Thyroid Gland Nodule|Thyroid Gland Papillary Carcinoma
Interventions: OTHER: Quality-of-Life Assessment|PROCEDURE: Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence of Lamnet (Lamotrigine)100mg Tablet With the Reference Product Lamictal 100mg (Lamotrigine) Tablet Under Fasting Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Lamotrigine tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LY3108743 in Healthy Participants and Participants With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo - Capsule|DRUG: LY3108743 - Capsule|DRUG: Placebo - Solution|DRUG: LY3108743 - Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Telemonitoring After Surgery to Preserve Limb Function in Optimizing Mobility in Cancer Survivors With Skeletal Metastases
Status: TERMINATED
Conditions: Bone Metastases|Cancer Survivor|Metastatic Malignant Neoplasm in the Bone
Interventions: OTHER: Monitoring Device|OTHER: Physical Activity Measurement|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Standard Follow-Up Care|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Silicone and Porous Plate Ahmed Glaucoma Valves
Status: COMPLETED
Conditions: Glaucoma
Interventions: DEVICE: Silicone plate Ahmed Glaucoma Valve (Model FP7)|DEVICE: Porous Plate Ahmed Glaucoma Valve (Model M4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DIETARY_SUPPLEMENT: 1-month of 60-40 MCT oil|DIETARY_SUPPLEMENT: 1-month of C8 MCT oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Antioxidant Supplement on Blood Vessel Health
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: MitoQ|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CS1001 in Subjects With Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer Stage III
Interventions: BIOLOGICAL: CS1001 monoclonal antibody|BIOLOGICAL: CS1001 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial of Sublingual Immunotherapy With a Solution of Grass Pollen Allergen Extract in Children
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: BIOLOGICAL: Grass pollen allergens in a water/glycerol solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of the SGLT-2 Inhibitor Empagliflozin in Patients With Diabetic Nephropathy (MEDiaN)
Status: TERMINATED
Conditions: Diabetic Nephropathies
Interventions: DRUG: Empagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Edaravone-Sodium Ozagrel Comparative Post-Marketing Study on Acute Ischemic Stroke
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: Edaravone|DRUG: Sodium Ozagrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare MPR With MP in Newly Diagnosed Multiple Myeloma Subjects 65 Years Old or Older.
Status: COMPLETED
Conditions: Newly Diagnosed Multiple Myeloma
Interventions: DRUG: Lenalidomide: Double-blind Induction|DRUG: Melphalan|DRUG: Prednisone|DRUG: Aspirin|DRUG: Placebo|DRUG: Lenalidomide: Double-blind Maintenance|DRUG: Lenalidomide: Open-label
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Coated Balloons for Prevention of Restenosis
Status: UNKNOWN
Conditions: Atherosclerosis|Restenosis|Limb Ishemia
Interventions: DEVICE: Balloon angioplasty (uncoated conventional balloon)|DEVICE: Balloon angioplasty (conventional but coated with 3 µg/mm2 paclitaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synchronization of Ovarian Stimulation for in Vitro Fertilization With Follicular Wave Emergence
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Ovulation induction with choriogonadotropin alfa|PROCEDURE: Aspiration of the dominant follicle|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Aesthetic Results of Two Common Incisions in External Rhinoplasty
Status: COMPLETED
Conditions: Cosmetic Outcome
Interventions: PROCEDURE: inverted V incision|PROCEDURE: stair step incisions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of NanoDoce® in Participants With Urothelial Carcinoma
Status: COMPLETED
Conditions: Bladder Cancer|Urothelial Carcinoma|Urinary Bladder Neoplasm|Urinary Bladder Cancer|Urogenital Neoplasms|Urologic Neoplasms|Urologic Cancer|Malignant Tumor of the Urinary Bladder|Cancer of the Bladder
Interventions: DRUG: NanoDoce (direct injection)|DRUG: NanoDoce (intravesical instillation) - Visit 2 Instillation|OTHER: Institutional Standard of Care|DRUG: NanoDoce (intravesical instillation) - Induction and Maintenance Instillations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A European Registry Study to Prospectively Observe Treatment Patterns and Outcomes in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Unresectable Locally Advanced (LA) or Metastatic Breast Cancer (mBC) (SAMANTHA)
Status: COMPLETED
Conditions: Breast Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Dextrose Prolotherapy in Patients With Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: Intra-articular and extra-articular Dextrose Prolotherapy injection|PROCEDURE: Intra-articular and extra-articular Saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anterior Versus Posterior Artisan Intraocular Lens Fixation in Aphakic Children With Insufficient Capsular Support.
Status: COMPLETED
Conditions: Cataracts Infantile|Subluxation of Lens|Intraocular Lens Complication|Corneal Endothelial Cell Loss
Interventions: PROCEDURE: Anterior enclavation|PROCEDURE: Posterior enclavation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Two Intravaginal Rings (IVRs) Containing Different Dose Strengths of Vicriviroc (MK-4176) and MK-2048
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: MK-2048A IVR (Low Dose)|DRUG: MK-2048A IVR (Original Dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Integrated Neuromuscular Inhibition Technique With Myofascial Release on Rhomboids Trigger Points
Status: COMPLETED
Conditions: Trigger Point Pain, Myofascial
Interventions: OTHER: Integrated neuromuscular inhibition technique|OTHER: Myofascial Release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of an HIV DNA Vaccine Followed by an HIV Adenoviral Vector Vaccine for Prevention of HIV Infection in the Americas and Africa
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC-HIVDNA016-00-VP|BIOLOGICAL: VRC-HIVADV014-00-VP|BIOLOGICAL: VRC-HIVDNA016-00-VP placebo|BIOLOGICAL: VRC-HIVADV014-00-VP placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Sustained Off-treatment Response After HBeAg Loss in Chronic Hepatitis B Patients Treated With Nucleos(t)Ide Analogues
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Continue NA treatment|DRUG: Discontinue NA Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osimertinib and Locally Ablative Radiotherapy in Patients With Synchronous Oligo-metastatic EGFR Mutant NSCLC (STEREO)
Status: TERMINATED
Conditions: NSCLC Stage IV|EGFR Gene Mutation
Interventions: DRUG: Osimertinib|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: DRUG: 21mg transdermal nicotine patch (Nicoderm CQ)|DRUG: 1mg nicotine nasal spray|DRUG: placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bisoprolol in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Bisoprolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of SGI-110 With Irinotecan Versus Regorafenib or TAS-102 in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Previously Treated Metastatic Colorectal Cancer
Interventions: DRUG: SGI-110 Dose Escalation|DRUG: Regorafenib|DRUG: TAS-102|DRUG: SGI-110|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NBTXR3 Crystalline Nanoparticles and Stereotactic Body Radiation Therapy in the Treatment of Liver Cancers
Status: TERMINATED
Conditions: Liver Cancer
Interventions: RADIATION: NBTXR3, IL or IA injection + SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Comparison of Intradermal Versus Sub-cutaneous Insulin and Glucagon Delivery in Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes
Interventions: PROCEDURE: Intradermal injection|PROCEDURE: Subcutaneous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DRUG: conivaptan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of MoodElite T-4003-1 on Improving Mood in a Healthy Adult Population With Mild to Moderate Depressive Symptoms Not Eligible for Therapeutic Intervention
Status: COMPLETED
Conditions: Mood
Interventions: DIETARY_SUPPLEMENT: MoodElite T-4003-1|DIETARY_SUPPLEMENT: Comparator|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intraoperative Volume Replacement Determined by the Plethysmograph Variability Index (PVI) With That Determined by the Delta PP in the Digestive, Gynecological, Urological, and Abdominal Surgery and Their Impact on the Length of Stay
Status: COMPLETED
Conditions: Abdomino-pelvic Surgery
Interventions: DRUG: Geloplasma (PVI)|DRUG: Geloplasma (delta PP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Tragus Pressure in Guiding Emergence From Anaesthesia
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Guiding Emergence From Anaesthesia With Tragus Pressure|PROCEDURE: Guiding Emergence From Anaesthesia Without Tragus Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate CCS1477 in Advanced Tumours
Status: RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer|Metastatic Breast Cancer|Non-small Cell Lung Cancer|Advanced Solid Tumors
Interventions: DRUG: CCS1477|DRUG: Abiraterone acetate|DRUG: Enzalutamide|DRUG: Darolutamide|DRUG: Olaparib|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy and Safety Study of the Magnetecs CGCI System for Intracardiac Mapping
Status: UNKNOWN
Conditions: Tachycardia, Supraventricular|Tachycardia, Ventricular
Interventions: PROCEDURE: Remote magnetic navigation|DEVICE: Magnetecs Catheter Guidance Control and Imaging system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC