pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Technical Performance of a New Cardiac Technology "IQ-SPECT" Applied to SCINTI-CT Myocardial Imaging With 99mTc-Sestamibi in Coronary Patients
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: myocardial IQ-SPECT imaging applied to scintigraphic imaging|DEVICE: scintigraphic imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Virtual Reality Distraction for Dental Anxiety (PILOT)
Status: RECRUITING
Conditions: Dental Anxiety|Dental Phobia|Dental Trauma|Dental Diseases
Interventions: DEVICE: Virtual Reality Distraction|BEHAVIORAL: Dental Clinic's Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NOA-12: BIBF1120 and R-RT in Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma Multiforme
Interventions: DRUG: BIBF 1120|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study Comparing the Efficacy and Safety of EP2006 and Filgrastim
Status: COMPLETED
Conditions: Chemotherapy Associated Neutropenia|Breast Cancer
Interventions: DRUG: EP2006|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open-Label Phase 2 Study of Ofatumumab (Arzerra) in Combination With Oral GSK2110183 in the Treatment of Relapsed and Refractory Chronic Lymphocytic Leukemia (CLL)
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: Ofatumumab with GSK2110183
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registry of Arthrex Hand and Wrist Products
Status: RECRUITING
Conditions: Ulnar/Radial Collateral Ligament Reconstruction|Ligament Repair or Reconstruction|Small Bone Fragments and Arthrodesis|Scapholunate Ligament Reconstruction|Carpal Fusion (Arthrodesis) of the Hand|Digital Tendon Transfers|Carpometacarpal Joint Arthroplasty
Interventions: DEVICE: Products listed in cohort description
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effectiveness of Acupuncture in Patients Diagnosed With Interstitial Cystitis
Status: RECRUITING
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: OTHER: ACUPUNCTURE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient and Family Partners in Heart Failure Care: Pilot Test of a Pre-visit Question Prompt List to Enhance Engagement During Medical Visits
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: Question/Topic Prompt List
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Topical Versus Intravenous Tranexamic Acid in TKA
Status: COMPLETED
Conditions: Total Blood Loss
Interventions: DRUG: normal saline|DRUG: Tranexamic Acid|DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mediators of Abnormal Reproductive Function in Obesity (MARO)
Status: COMPLETED
Conditions: Infertility, Female|Obesity
Interventions: OTHER: Microdialysis|DIETARY_SUPPLEMENT: Vascepa - Fish Oil|DRUG: Aspirin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: AnaConDa Long Term Sedation Study
Status: COMPLETED
Conditions: Intubated Requiring Sedation for Greater Than 48 Hours
Interventions: DRUG: Isoflurane|DRUG: Propofol/midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C
Status: COMPLETED
Conditions: Cirrhosis|Chronic Hepatitis C|Hepatitis C|Hepatitis C, Chronic
Interventions: DRUG: DUAL|DRUG: QUAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
Status: COMPLETED
Conditions: Cocaine Addiction
Interventions: DRUG: placebo|DRUG: disulfiram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability Trial of Microbial Inulinase
Status: COMPLETED
Conditions: Digestive Health|Gastrointestinal Health
Interventions: DIETARY_SUPPLEMENT: Inulinase|DIETARY_SUPPLEMENT: Maltodextrin placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TAP Block vs Spinal Orphine for Postoperative Caesarean Section Analgetics
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: Transversus Abdominal Plane Block|PROCEDURE: Spinal Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on Continuous Intravenous of Unfractionated Heparin (UFH) to Treat Progressive Cerebral Infarction
Status: COMPLETED
Conditions: Heparin Causing Adverse Effects in Therapeutic Use|Heparin-induced Thrombosis|Acute Cerebral Ischemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robotic Assisted Versus Laparoscopic Cholecystectomy - Outcome and Cost Analyses of a Case-Matched Control Study
Status: COMPLETED
Conditions: Cholecystolithiasis
Interventions: PROCEDURE: robotic assisted cholecystectomy|PROCEDURE: Laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creatine Monohydrate Versus Creatine Hydrochloride on Strength and Body Composition in Elite Team-Sport Athletes
Status: COMPLETED
Conditions: Healthy Lifestyle
Interventions: DIETARY_SUPPLEMENT: Creatine Monohydrate|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Creatine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Change in Fat Distribution in Overweight and Obese Subjects With Type 2 Diabetes After Insulin Treatment
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: USG Nerve Blocks for ACL Reconstruction
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Ropivacaine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Placebo-Controlled Study: CroFab® vs Placebo for Copperhead Snake Envenomation
Status: COMPLETED
Conditions: Snake Bites
Interventions: BIOLOGICAL: Crotalidae polyvalent immune fab (ovine)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Avandamet 6 mg/1500 mg (ttd)|DRUG: Avandamet 4 mg/1000 mg (ttd)|DRUG: Avandamet 2 mg/500 mg (ttd)|DRUG: Avandamet 8 mg/ 2000 mg (ttd)|DRUG: Metformin 500 mg (ttd)|DRUG: Metformin 1000 mg (ttd)|DRUG: Metformin 1500 mg (ttd)|DRUG: Metformin 2000 mg (ttd)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Frailty on Opioid Consumption
Status: UNKNOWN
Conditions: Frailty|Opioid Use|Knee Arthropathy
Interventions: DEVICE: Patient-controlled analgesia pump (PCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Lesinurad and Intravenous [14C]Lesinurad
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lesinurad 400 mg|DRUG: [14C]lesinurad (100 μg per 10 mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stool Composition and Stool Characteristics in Healthy Term Infants Fed Human Milk or Infant Formulas
Status: COMPLETED
Conditions: Stool Composition
Interventions: OTHER: S-26 Gold|OTHER: S-26 Gold EF1|OTHER: S-26 Gold EF2|OTHER: S-26 Gold EF3|OTHER: Human Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Explore Acceptance and Performance of Using a Digital Medicine System With Healthcare Professionals and Adults With Schizophrenia, Schizoaffective Disorder, or First Episode Psychosis on an Oral Atypical Antipsychotic
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|First Episode Psychosis
Interventions: DEVICE: Digital Medicine System|DRUG: Aripiprazole|DRUG: Olanzapine|DRUG: Quetiapine|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison Between Hemitrapeziectomy and Total Trapeziectomy With Ligament Reconstruction and Tendon Interposition in Trapeziometacarpal Osteoarthritis II-III Eaton-Littler
Status: COMPLETED
Conditions: Trapeziometacarpal Osteoarthritis
Interventions: PROCEDURE: Ligamentoplasty with partial trapeziectomy|PROCEDURE: Ligamentoplasty with total trapeziectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Personalized NeoAntigen Cancer Vaccine Combined With Anti-PD-1 in Melanoma
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: DRUG: Peptide|DRUG: Anti-PD-1|DRUG: rhGM-CSF|DRUG: Imiquimod 5% Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Clinical Study to Evaluate Sodium Oxybate (Xyrem) on Potential Endocrine Changes
Status: COMPLETED
Conditions: Narcolepsy With Cataplexy
Interventions: DRUG: Sodium Oxybate (Xyrem)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder
Status: UNKNOWN
Conditions: PTSD
Interventions: DRUG: 5 mL of 0.5% preservative-free bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvanted Influenza Vaccination in U.S. Nursing Homes
Status: COMPLETED
Conditions: Influenza|Influenza-like Illness
Interventions: BIOLOGICAL: adjuvanted trivalent influenza vaccine|BIOLOGICAL: trivalent influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Suspension of Mechanical Ventilation in Ureteroscopic Lithotripsy Under General Anesthesia
Status: UNKNOWN
Conditions: Hypercapnia|Hypoxia
Interventions: OTHER: PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial
Status: RECRUITING
Conditions: Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8|Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8|Locally Advanced Merkel Cell Carcinoma|Metastatic Merkel Cell Carcinoma|Refractory Merkel Cell Carcinoma|Unresectable Merkel Cell Carcinoma
Interventions: DRUG: Avelumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|DRUG: Tuvusertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Genetic Causes of Calcific Aortic Valve Disease
Status: RECRUITING
Conditions: Calcific Aortic Stenosis|Calcific Aortic Stenosis - Bicuspid Valve|Aortic Valve Disease|Aortic Valve Calcification|Aortic Diseases|Aortic Aneurysm|Aortic Valve Cusp Abnormality|Aortic Valve Disease Mixed|Aortic Valve Insufficiency
Interventions: PROCEDURE: Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of an Organized Consultation "Return Home" of Patients With a Cancer (CREDO)
Status: COMPLETED
Conditions: METASTATIC CANCER
Interventions: OTHER: current standard of care|OTHER: CREDO standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Nasopharyngeal Carcinoma|Solid Tumor
Interventions: DRUG: BL-B01D1|DRUG: PD-1 Monoclonal Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Skin and Soft Tissue Abscesses in Pediatric Patients After Incision and Drainage
Status: COMPLETED
Conditions: Abscess
Interventions: DRUG: oral trimethoprim/sulfamethoxazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fixing the Short Stay Central Venous Catheter: Comparison of Two Techniques
Status: UNKNOWN
Conditions: Suture, Complication
Interventions: PROCEDURE: Fixation with "ballerina" technique and flip|PROCEDURE: Habitual Fixation|OTHER: Evaluation on the third and fift days, filogisticos and infectious signs, fixing loss, and culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: metoclopramide, injection,20mg, one time|DRUG: Sumatriptan, injection, 6 mg, one time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Trial of Docetaxel With or Without XH1 in Non-small Cell Lung Cancer (NSCLC) Patients
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Docetaxel|DRUG: Chinese traditional medicine XH1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Muscular Activation Levels Around the Scapula and Shoulder in Exercises Which Body Weight is Carried
Status: UNKNOWN
Conditions: Electromyography|Exercise|Exercise Therapy|Shoulder
Interventions: DIAGNOSTIC_TEST: Clinical Tests|OTHER: MVIC measurements|OTHER: Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: BonyPid-500TM Bone Graft Substitute Study
Status: COMPLETED
Conditions: Peri Implantitis
Interventions: DEVICE: BonyPid 500TM implantation concomitantly to SOC treatment|OTHER: SOC treatment only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety of Driving After Minor Surgery With Monitored Anesthesia Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Minor Surgical Procedures With Monitored Anesthesia Care|Driving Performance After Minor Ambulatory Surgery
Interventions: DRUG: Midazolam|DRUG: Sufentanil|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling
Status: COMPLETED
Conditions: Optimum Propionate Delivery to the Large Intestine
Interventions: DIETARY_SUPPLEMENT: Inulin|DIETARY_SUPPLEMENT: 2.5 g of propionate|DIETARY_SUPPLEMENT: 5 g of propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Do Fair Comparisons or Harms Data Increase Responsiveness to Feedback About Antibiotic Prescribing: 2x2 Factorial Trial
Status: COMPLETED
Conditions: Infection
Interventions: BEHAVIORAL: Audit and Feedback (A&F)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Detecting Generalized Tonic-Clonic Seizures With a Seizure Detection and Warning System in Epilepsy Patients
Status: COMPLETED
Conditions: Epilepsy|Generalized Tonic-Clonic Seizures
Interventions: DEVICE: Brain Sentinel Seizure Detection and Warning System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Inverse Ratio Ventilation in Neonatal Open Repair of Tracheoesophageal Fistula.
Status: COMPLETED
Conditions: Tracheo Esophageal Fistula
Interventions: PROCEDURE: Inverse Ratio Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Safety and Efficacy of SGLT2is Among LN Patients
Status: NOT_YET_RECRUITING
Conditions: Lupus Nephritis
Interventions: DRUG: Dapagliflozin 10mg Tab orally once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: PMR Versus MLD on RLS and Sleep Quality in Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis Complication
Interventions: OTHER: Progressive muscle relaxation (PMR)|OTHER: cnotrol group|OTHER: Manual lymphatic drainage (MLD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of a Highly Cross-linked Polyethylene Acetabular Component Doped With Vitamin E in Total Hip Arthroplasty of the Young and Active Subject
Status: RECRUITING
Conditions: Hip Arthropathy
Interventions: DEVICE: Prosthesis with CoPXE couple.|DEVICE: Prosthesis with CoC torque.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Is the Endoscopic Remission Evaluation, Using the CREDO 1 Index / Score in CD Patients in Clinical Remission at Baseline, Predictive of Sustained Clinical Remission Using a 2-year Follow up
Status: UNKNOWN
Conditions: CD
Interventions: DIAGNOSTIC_TEST: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety, Preliminary Efficacy, and Pharmacokinetic Properties of LASN01 in Healthy Subjects and in Patients With Pulmonary Fibrosis or Thyroid Eye Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Fibrosis|Thyroid Eye Disease
Interventions: DRUG: LASN01|DRUG: LASN01|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Investigational Dulaglutide Doses in Participants With Type 2 Diabetes on Metformin Monotherapy
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dulaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fatigue in Breast Cancer Survivors
Status: UNKNOWN
Conditions: Breast Cancer|Cancer Survivor|Fatigue|Psychosocial Effects of Cancer and Its Treatment
Interventions: GENETIC: protein analysis|OTHER: laboratory biomarker analysis|OTHER: mass spectrometry|OTHER: questionnaire administration|PROCEDURE: assessment of therapy complications|PROCEDURE: cognitive assessment|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study to Evaluate Combination Therapy With Nebivolol and Lisinopril vs. Placebo and Monotherapy in Patients With Stage 2 Diastolic Hypertension
Status: COMPLETED
Conditions: Stage 2 Diastolic Hypertension
Interventions: DRUG: nebivolol and lisinopril (free combination)|DRUG: nebivolol monotherapy|DRUG: lisinopril monotherapy|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-operative Cefazolin Prophylaxis at Time of Cesarean Delivery in the Obese Gravida
Status: COMPLETED
Conditions: Obesity|Pregnancy
Interventions: DRUG: Pre-operative cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Post-operative Voiding Trial on Length of Stay Following Laparoscopic Hysterectomy: A Prospective, Randomized Control Trial
Status: COMPLETED
Conditions: Minimally Invasive Surgical Procedure|Hysterectomy|Urinary Retention
Interventions: OTHER: Active voiding trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CBT-I to Improve Functional Outcomes in Veterans With Psychosis
Status: RECRUITING
Conditions: Insomnia|Psychosis
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy-Insomnia|BEHAVIORAL: Health and Wellness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two High Performance Guidewires in ERCP
Status: COMPLETED
Conditions: Stenosis of Bile Duct
Interventions: DEVICE: VisiGlide™ angled tip|DEVICE: VisiGlide2™ angled tip|DEVICE: VisiGlide™ straight tip|DEVICE: VisiGlide2™ straight tip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-dose, Dose-escalation Study of a Long-acting MOD-5014 in Healthy Adult Male
Status: COMPLETED
Conditions: Hemophilia A or B With Inhibitors
Interventions: BIOLOGICAL: MOD-5014|OTHER: MOD-5014 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Surgical Management of Postpartum Haemorrhage Without Embolization
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Second Line Management|Uterine Arteries Embolization|Surgical Management of Haemorrhage
Interventions: OTHER: Arterial embolization and/or surgical management.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of the Efficacy of Myofascial Chain Release Techniques on Plantar Fasciitis
Status: UNKNOWN
Conditions: Plantar Fascitis
Interventions: OTHER: Myofascial Chain Release Techniques|OTHER: Local Release Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Anaesthesia for Liver Transplantation: a Pilot Study
Status: COMPLETED
Conditions: Anesthesia|Liver Transplant
Interventions: DEVICE: Automated titration of propofol and remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bicarbonate Profiling in Dialysis Fluid on Phosphate Removal During Hemodialysis and Blood pH
Status: COMPLETED
Conditions: Phosphorus Metabolism Disorders|Acid-Base Balance Disorder
Interventions: OTHER: Group 1: B) Dbic 35 -30 mmol/L C) Dbic 30- 35 mmol/L|OTHER: Group 2: C) Dbic 30 -35 mmol/L B) Dbic 35- 30 mmol/L
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Around Immediate Implant
Status: COMPLETED
Conditions: Immediate Implant Placement|Bone Regeneration|Alveolar Bone Resorption
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Oxidative Stress on Erythrocyte Biology
Status: RECRUITING
Conditions: Sickle Cell Disease Without Crisis
Interventions: BIOLOGICAL: G6PD Deficient Red Blood Cell Transfusion|BIOLOGICAL: Non-G6PD deficient Red Blood Cell Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assess Aesthetic Improvement With QM1114-DP in Subjects With Moderate to Severe Lateral Canthal Lines and Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines|Canthal Lines
Interventions: BIOLOGICAL: QM1114-DP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Qigong Therapy in Patients With Advanced Lung and Gastrointestinal Cancer Undergoing Chemotherapy
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Cancer of the Gastrointestinal Tract
Interventions: BEHAVIORAL: Standard Exercise|BEHAVIORAL: Qigong Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Role of Gender Transformative Interventions to Strengthen Gender Equity and Improve Immunization Outcomes
Status: NOT_YET_RECRUITING
Conditions: Gender Equality and Its Impact on Immunization Uptake
Interventions: BEHAVIORAL: Gender and immunization activities|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic of Ceftriaxone in Septic ICU Patients
Status: UNKNOWN
Conditions: Sepsis|Severe Sepsis|Septic Shock
Interventions: DRUG: ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Solute Carrier Family 5 Member 2 (SLC5A2) Deficiency and the Glucagon-Incretin Axis
Status: UNKNOWN
Conditions: Familial Renal Glucosuria|Diabetes Mellitus|Cardiovascular Diseases
Interventions: OTHER: Mixed-meal-tolerance-test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of HL301 Versus Placebo in Acute Bronchitis Patients
Status: COMPLETED
Conditions: Acute Bronchitis
Interventions: DRUG: HL301|DRUG: HL301(Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alcohol Use and Chronic Pain Among Primary Care Patients
Status: COMPLETED
Conditions: Alcohol Drinking|Chronic Pain
Interventions: BEHAVIORAL: mhealth-pc for alcohol and pain|BEHAVIORAL: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Efficacy, and Safety of Human Plasma-Derived Fibrinogen (FIB Grifols) in Participants With Congenital Afibrinogenemia
Status: COMPLETED
Conditions: Congenital Afibrinogenemia
Interventions: BIOLOGICAL: Human Plasma-Derived Fibrinogen Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Antiretroviral Drug-Drug Interaction Study in Healthy Volunteers (DDI)
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: BMS-663068|DRUG: Darunavir|DRUG: Cobicistat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Opioid Free Anesthesia in Bariatric Surgeries
Status: COMPLETED
Conditions: Adverse Effect of Drugs and Medicaments in Therapeutic Use|Adverse Effects in the Therapeutic Use of Anaesthetics
Interventions: DRUG: Fentanyl|DRUG: Dexmedetomidine Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of OSI-211 vs. Topotecan in Patients With Relapsed Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: OSI-211 (Liposomal Lurtotecan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Personalized Robotic Therapy
Status: TERMINATED
Conditions: Stroke
Interventions: DEVICE: Arm Light Exoskeleton Rehab Station (ALEx RS)|DEVICE: Arm Light Exoskeleton Rehab Station (ALEx RS) - automatically personalized
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pulse Fibre Supplementation on Obesity and the Metabolic Syndrome
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Pulse fibre|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Study of Neurodegenerative Disorders
Status: RECRUITING
Conditions: MLD|Krabbe Disease|ALD|MPS I|MPS II|MPS III|Vanishing White Matter Disease|GM3 Gangliosidosis|PKAN|Tay-Sachs Disease|NP Deficiency|Osteopetrosis|Alpha-Mannosidosis|Sandhoff Disease|Niemann-Pick Diseases|MPS IV|Gaucher Disease|GAN|GM1 Gangliosidoses|Morquio Disease|S-Adenosylhomocysteine Hydrolase Deficiency|Batten Disease|Pelizaeus-Merzbacher Disease|Leukodystrophy|Lysosomal Storage Diseases|Purine Nucleoside Phosphorylase Deficiency|Multiple Sulfatase Deficiency Disease
Interventions: OTHER: Palliative Care|BIOLOGICAL: Hematopoetic Stem Cell Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tramadol Infiltration for Tonsillectomy
Status: WITHDRAWN
Conditions: Postoperative Pain
Interventions: DRUG: Tramadol 2mg/kg|DRUG: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Occupational Passive Back-exoskeletons on the Biomechanical Load of Warehouse Workers.
Status: RECRUITING
Conditions: Work-related Musculoskeletal Disorders
Interventions: DEVICE: Use of an occupational passive back-exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hepatic Arterial Infusion Combined With Lenvatinib and Camrelizumab for Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: Hepatic arterial infusion chemotherapy|DRUG: Lenvatinib|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)
Status: RECRUITING
Conditions: B-Cell Malignancies
Interventions: DRUG: Parsaclisib|DRUG: parsaclisib + itacitinib|DRUG: parsaclisib + ruxolitinib|DRUG: parsaclisib + ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-based Intervention in Cardioverter-defibrillator Patients to Enhance Quality of Life
Status: UNKNOWN
Conditions: Heart Diseases|Implantable Cardioverter-Defibrillators
Interventions: BEHAVIORAL: web-based multifactorial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Lateral Sinus Floor Elevation in Implant Therapy.
Status: UNKNOWN
Conditions: Edentulous; Alveolar Process, Atrophy
Interventions: PROCEDURE: L-PRF block|PROCEDURE: DBBM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Efficacy of High Dose Escitalopram for the Treatment of Obsessive-Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DES Versus BiOSS LIM - POLBOS II Study
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Coronary angioplasty with stent implantation|DRUG: Dual antipletlet therapy (DAPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCP
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
Status: COMPLETED
Conditions: Atherosclerosis|Hypercholesterolemia
Interventions: DRUG: Statins, HMG CoA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety, Tolerability, and Pharmacokinetics of an Investigational, Injectable HIV Medicine (GSK1265744) in HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: GSK1265744 Tablets|DRUG: Injectable GSK1265744|DRUG: Placebo for GSK1265744 Tablets|DRUG: Injectable Placebo for GSK1265744
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ranibizumab to Treat Type 2 Idiopathic Macular Telangiectasia (RAMA-Trial)
Status: COMPLETED
Conditions: Type 2 Idiopathic Macular Telangiectasia
Interventions: DRUG: Intravitreal injection ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic Efficacy in VRE Eradication
Status: COMPLETED
Conditions: VRE Colonization
Interventions: DIETARY_SUPPLEMENT: lactobacillus probiotic strain|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Dose Escalation, Dose Expansion Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-575, in Subjects With Advanced Tumors.
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: MEDI-575
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety and Efficacy of the Atrial Shunt Implant System in the Treatment of Patients With Chronic Left Heart Failure
Status: RECRUITING
Conditions: Left Heart Failure
Interventions: DEVICE: Atrial shunt implant system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Laser Interstitial Thermal Therapy (LITT) Treatment Response Assessment With Fluciclovine PET MR
Status: WITHDRAWN
Conditions: Brain Metastases|Cancer|Gliomas|Glioblastoma
Interventions: DRUG: F18 Fluciclovine|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Feeding Infant Formula With Enriched Protein Fractions in the US
Status: TERMINATED
Conditions: Declarative Memory
Interventions: OTHER: Cow's milk-based infant formula|OTHER: Cow milk-based infant formula with enriched protein fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety and Efficacy Study of Pembrolizumab (MK-3475) in Chinese Participants With Locally Advanced or Metastatic Melanoma (MK-3475-151/KEYNOTE-151)
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-61803534 and to Evaluate the Effect of JNJ-61803534 on the Pharmacokinetics of Midazolam in Healthy Participants
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: JNJ-61803534|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: School Intervention Program to Promote Healthy Lifestyle Among Male Adolescent Students in King Faisal Residential City, Jeddah, Western Region, 2014-15
Status: COMPLETED
Conditions: Physical Activity|Sedentary Behaviors|Dietary Habits|Obesity
Interventions: BEHAVIORAL: Educational program for 2 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Partial Rib Resection On the Control of Post-thoracotomy Pain
Status: COMPLETED
Conditions: Pain, Postoperative|Iatrogenic Injury|Post-thoracotomy Pain Syndrome
Interventions: PROCEDURE: Partial rib resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: To Determine the Objective Response Rate of 4 Cycles of Docetaxel + Anthracycline (Epirubicin or Doxorubicine) Followed by 4 Cycles of Docetaxel Single Agent
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients
Status: TERMINATED
Conditions: Infertility, Male
Interventions: DIAGNOSTIC_TEST: Ejaculatory abstinence less than 24 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel) and Immunotherapy (Pembrolizumab) for Metastatic Triple-Negative Breast Cancer
Status: SUSPENDED
Conditions: Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Unresectable Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Decitabine and Cedazuridine|PROCEDURE: Magnetic Resonance Imaging|DRUG: Paclitaxel|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Consolidation Treatment With Iodine I 131 Tositumomab for Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Iodine I 131 Tositumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Randomized Controlled Trial of Brazilian Jiu Jitsu vs. Yoga for Symptoms of PTSD
Status: ACTIVE_NOT_RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: OTHER: Brazilian Jiu Jitsu|OTHER: Hatha Yoga|OTHER: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of a Home-based Nutrition and Exercise Program on Quality of Life of Palliative Cancer Outpatients
Status: RECRUITING
Conditions: Cancer, Gastrointestinal|Cancer, Lung|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Whey protein supplement high in leucine and β-hydroxy-β-methylbutyrate (HMB)|BEHAVIORAL: Standardized nutritional program|BEHAVIORAL: Standardized exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Autologous heMatopoietic Stem Cell Transplantation Versus Alemtuzumab, Cladribine or Ocrelizumab for RRMS (RAM-MS)
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Cyclophosphamide and ATG|DRUG: Alemtuzumab|DRUG: Cladribine Pill|DRUG: Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The HYsteroscopic Miscarriage MaNagement Trial: A Pilot RCT Investigating a Novel Management Pathway for RPOC
Status: COMPLETED
Conditions: Retained Products After Miscarriage
Interventions: PROCEDURE: Outpatient hysteroscopy|BEHAVIORAL: Expectant management|DRUG: Medical management|DRUG: Antibiotic|PROCEDURE: Surgical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UCSD Take Charge Study
Status: COMPLETED
Conditions: Overweight|Obese|Obesity|Diabetic|Type 2 Diabetes
Interventions: OTHER: Higher Carbohydrate, Lower Fat Diet|OTHER: Lower carbohydrate, Higher fat diet|OTHER: Individualized Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Atypical Antipsychotic and Valproate Combination Therapy on Glucose and Lipid Metabolism in Schizophrenia
Status: COMPLETED
Conditions: Insulin Resistance|Body Composition
Interventions: DRUG: Depakote (valproate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Icotinib as Adjuvant Therapy in Treating Non-small-cell Lung Cancer Patients With Positive EGFR Mutation
Status: UNKNOWN
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: 1-year treatment with icotinib|DRUG: 2-year treatment with icotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Colorectal
Interventions: DRUG: Recombinant Vaccinia GM-CSF; RAC VAC GM-CSF (JX-594)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of CGMS to Detect Alterations of Blood Glucose in Thalassemic Patients
Status: COMPLETED
Conditions: Diabetes|Prediabetes|B-Thalassemia
Interventions: DEVICE: insulin pump/CGMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Stereotactic Body Radiation and Monoclonal Antibody to OX40 (MEDI6469) in Breast Cancer Patients With Metastatic Lesions
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Lung Metastases|Liver Metastases
Interventions: BIOLOGICAL: MEDI6469
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT