pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Avatar Intervention for the Treatment of Cannabis Use Disorder in Patients With Severe Mental Health Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychotic Disorders|Cannabis Use Disorder|Mental Health Disorder
Interventions: BEHAVIORAL: Avatar Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dexmedetomidine in Spine Surgery
Status: COMPLETED
Conditions: Collapse of Thoracic Vertebra|Collapse of Lumbar Vertebrae
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DNA Plasmid Encoding a Modified Human Telomerase Reverse Transcriptase (hTERT), Invac-1 in Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: BIOLOGICAL: INVAC-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Low Dose Sugammadex Combined With Neostigmine and Glycopyrrolate Versus Full Dose Sugammadex for Reversal of Rocuronium-induced Neuromuscular Blockade: a Cost Saving Strategy"
Status: COMPLETED
Conditions: Anesthesia Recovery
Interventions: DRUG: Sugammadex|DRUG: Sugammadex|DRUG: Neostigmine|DRUG: glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Isotretinoin on Muscle Strength in Patients With Acne Vulgaris: A Prospective Controlled Study
Status: COMPLETED
Conditions: Muscle Strength
Interventions: DEVICE: Isokinetic device (Biodex System 4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Carboplatin and Temozolomide (Temodar) for Recurrent and Symptomatic Residual Brain Metastases
Status: COMPLETED
Conditions: Brain Tumor|Brain Metastases
Interventions: DRUG: carboplatin|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Intervention Effect of a Hybrid Exercise Program on Elderly With Sarcopenia
Status: COMPLETED
Conditions: Sarcopenia
Interventions: BEHAVIORAL: self-determine sequence exercise program|BEHAVIORAL: resistance training|BEHAVIORAL: Taichi exercise and resistance training|BEHAVIORAL: Randomly selected exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Levonorgestrel-releasing Intrauterine Device on Obese Women: Effects on Hemostatic and Arterial Function
Status: UNKNOWN
Conditions: Contraception Desired|Obesity
Interventions: DEVICE: Levonorgestrel releasing device|DEVICE: Cu-IUD insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: GS-0201|DRUG: Sacituzumab Govitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy With 5-Fluorouracil, Interferon-an Interleukin-2, & Thalidomide for Metastatic, Advanced or Recurrent Renal Cell Carcinoma
Status: COMPLETED
Conditions: Kidney|Cancer
Interventions: DRUG: 5-Flourouracil, Interferon-a, IL-2 and Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Next-generation Effects of Vitamin D Supplementation in Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Growth|Vitamin D Supplementation|Immune System Diseases|Child Development
Interventions: OTHER: Intrauterine 90µg D-vitamin|OTHER: Intrauterine 10µg D-vitamin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Performance of Ultrasound in the Early Diagnosis of Vocal Cords Paralysis
Status: COMPLETED
Conditions: Thyroidectomy|Paralysis of Vocal Cords
Interventions: DIAGNOSTIC_TEST: Pre and postoperative ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Asymmetry of the Center of Pressure During Gait After Amputation of Lower Limbs
Status: COMPLETED
Conditions: Lower Limb Amputation Below Knee (Injury)|Lower Limb Amputation Above Knee (Injury)
Interventions: OTHER: usual care : Evaluation of walking on a baropodometric platform
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Induction Chemotherapy With GP Versus TPF in the Treatment of Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: A combination of Gemcitabine and cisplatin|DRUG: A combination of Docetaxel, cisplatin and 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Positive End Expiratory Pressures on Regional Cerebral Oxygen Saturation
Status: COMPLETED
Conditions: Regional Cerebral Oxygen Saturation
Interventions: OTHER: 5 cmH2O Positive end-expiratory pressure (PEEP)|OTHER: 10 cmH2O Positive end-expiratory pressure (PEEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Remotely Programmed Deep Brain Stimulation of the Bilateral Habenula for Treatment- Resistant Major Depression: An Open Label Pilot Trial
Status: TERMINATED
Conditions: Treatment Resistant Major Depressive Disorder
Interventions: PROCEDURE: Bilateral surgical implantation of DBS system to Habeluna|OTHER: Follow-up Period
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Study to Assess the Effects of Repeated Dosing of SAR247799 on Endothelial Function in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Microvascular Coronary Artery Disease
Interventions: DRUG: SAR247799|DRUG: Placebo|DRUG: Sildenafil|DRUG: Acetylcholine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety Evaluation Trial of TEV-48125 Self-administered in Migraine Patients
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Each subject will subcutaneously self-administer TEV 48125 at 225 mg/1.5 mL (150 mg/mL) once monthly for a total of 2 doses.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stress Generation and Recurrent Depression: The Role of Differential Treatment Response
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Interpersonal Therapy|DRUG: Antidepressant medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Respiratory Support After Delivery on Infants Born Before 28 Weeks Gestational Age
Status: COMPLETED
Conditions: Respiration; Insufficient or Poor, Newborn|Infant, Premature, Diseases
Interventions: DEVICE: T-piece used for respiratory support (several manufacturers)|DEVICE: New system used for respiratory support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Clinical Trial to Investigate Pharmacokinetics and Drug Interaction of Crestor and Glucodown OR SR in Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics and Drug Interaction of Crestor and Glucodown SR
Interventions: DRUG: Crestor 10mg(Rosuvastatin 10mg), Glucodown OR SR 750mg(Metformin SR 750mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Assess the Safety and Efficacy of Secukinumab in Alleviating Symptoms of Discoid Lupus Erythematosus
Status: WITHDRAWN
Conditions: Discoid Lupus Erythematosus
Interventions: DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durability of Combination Therapy With Exenatide/Pioglitazone/Metformin vs. Conventional Therapy in New Onset T2DM
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: metformin\pioglitazone\exenatide|DRUG: metformin, glyburide and glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tiotropium in Combination With Concomitant Cimetidine or Ranitidine in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cimetidine + Tiotropium|DRUG: Ranitidine + Tiotropium|DRUG: Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Ultrasound Neuromodulation Effects in Diabetes
Status: RECRUITING
Conditions: Insulin Sensitivity
Interventions: DEVICE: Ultrasound|DIAGNOSTIC_TEST: OGTT with unlabeled glucose and liver NMR|DIAGNOSTIC_TEST: OGTT with carbon-13 labeled glucose and liver NMR|DIAGNOSTIC_TEST: CGM glucose reading|DIAGNOSTIC_TEST: HEC - Hyperinsulinemic-Euglycemic-Clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Hypnosis for Sleep Quality for Individuals With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Poor Quality Sleep
Interventions: BEHAVIORAL: Self-Administered Hypnosis|BEHAVIORAL: Self-Administered White Noise Hypnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Epoetin Alfa in Patients With Anemia as a Result of Advanced Cancer and Treatment With Aggressive Chemotherapy
Status: COMPLETED
Conditions: Anemia|Neoplasms
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
Status: UNKNOWN
Conditions: Lung Injury|ARDS|Acute Cardiac Event|Covid19|Ultrasound|Hypoxemia|Acute Respiratory Distress Syndrome
Interventions: DIAGNOSTIC_TEST: Point of Care Ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Dual Bronchodilator Treatment on Cardiopulmonary Interactions in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Tiotropium + Olodaterol|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Physical Training on Bone Turnover and Quality of Life in Osteopenic Postmenopausal Women.
Status: COMPLETED
Conditions: Osteopenia|Bone Turnover Markers|Quality of Life
Interventions: OTHER: Physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulant Drug Treatment of Attention-Deficit Hyperactivity Disorder (AD/HD), Inattentive Type
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: methylphenidate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
Status: TERMINATED
Conditions: Trauma|Fractures, Closed|Children, Only|Deep Sedation|Ketamine
Interventions: DRUG: Intravenous Ketamine|DRUG: Intranasal Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Explore the Efficacy of Alprostadil Liposomes Injection in the Prevention of CI-AKI
Status: RECRUITING
Conditions: Contrast-induced Acute Kidney Injury
Interventions: DRUG: Alprostadil liposome injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety and Efficacy of Subcutaneously Administered REGN475 in Patients With Osteoarthritis of the Knee
Status: WITHDRAWN
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: REGN475|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab Combined With MSCs in the Treatment of PNS (3-4 Stage of CKD)
Status: UNKNOWN
Conditions: Renal Insufficiency, Chronic|Nephrotic Syndrome
Interventions: DRUG: Rituximab|DRUG: conventional therapy|DRUG: Mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moxibustion for the Prevention of Hemorrhagic Cystitis After Allo-HSCT
Status: RECRUITING
Conditions: Moxibustion|Hematopoietic Stem Cell Transplantation|Hemorrhagic Cystitis|Prevention
Interventions: OTHER: Moxibustion|OTHER: Symptomatic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cooperative Group for Clinical Research in G-POEM (POP), Jiangsu, China
Status: UNKNOWN
Conditions: Gastric Peroral Endoscopic Pyloromyotomy (G-POEM)
Interventions: PROCEDURE: Gastric peroral endoscopic pyloromyotomy (G-POEM)|DRUG: Esomeprazole + Mosapride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study on Optimization and Evaluation of Integrated Chinese and Western Medicine for pSS Glandular Damage
Status: ENROLLING_BY_INVITATION
Conditions: Primary Sjögren Syndrome
Interventions: DRUG: Yi Qi Yang Yin Decoction|DRUG: Hydroxychloroquine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-world Study to Evaluate the Safety and Immunogenicity of a Third-dose Booster After Two Doses of an Inactivated COVID-19 Vaccine
Status: UNKNOWN
Conditions: COVID-19|Vaccine Reaction
Interventions: BIOLOGICAL: an inactivated SARS-CoV-2 vaccine named BBIBP-CorV
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COMbination of Bipolar Androgen Therapy and Nivolumab
Status: COMPLETED
Conditions: Castration-resistant Prostate Cancer|Metastatic Prostate Cancer|Prostate Cancer
Interventions: DRUG: Testosterone cypionate|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate the Long-Term Safety, Tolerability, and Maintenance of Effect of BIIB074
Status: TERMINATED
Conditions: Neuropathic Pain From Lumbosacral Radiculopathy
Interventions: DRUG: BIIB074
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Chewing Gum Hasten Return of Bowel Function Post-Operatively in Patients Undergoing Spinal Surgery
Status: COMPLETED
Conditions: Return of Bowel Function Following Spinal Surgery
Interventions: DIETARY_SUPPLEMENT: Chewing gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emphasizing the Personal Versus the Social in Educational Interventions For Decreasing Vaccine Hesitancy
Status: UNKNOWN
Conditions: Vaccine Hesitancy|Communication
Interventions: BEHAVIORAL: "Personal" intervention|BEHAVIORAL: "Social" intervention|BEHAVIORAL: "Personal" + "Social" intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
Status: RECRUITING
Conditions: Parkinson's Disease and Parkinsonism
Interventions: DEVICE: High-Frequency, ipsilateral M1|DEVICE: High-Frequency, bilateral M1|DEVICE: High-Frequency, Lt. DLPFC|DEVICE: High-Frequency, bilateral M1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ringing a Bell on the Final Day of Radiation Therapy in Improving the Memory of Distress in Cancer Patients
Status: COMPLETED
Conditions: Distress|Malignant Neoplasm
Interventions: OTHER: Memory Intervention|OTHER: Questionnaire Administration|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I Study to Compare 3 Different Strengths of an Extended Release Formulation of ASP015K to an Immediate Release Formulation of ASP015K
Status: COMPLETED
Conditions: Pharmacokinetics of ASP015K|Food Effect|Healthy Volunteers
Interventions: DRUG: ASP015K ER|DRUG: ASP015K IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety, Efficacy and Acceptability of Flavocoxid (Limbrel)A Pilot Study
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: flavocoxid|DRUG: Naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oblimersen, Cytarabine, and Daunorubicin in Treating Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: BIOLOGICAL: oblimersen sodium|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies
Status: WITHDRAWN
Conditions: Adenoma, Pleomorphic|Mixed Salivary Gland Tumor|Salivary Gland Tumor, Mixed|Syringoma, Chondroid
Interventions: RADIATION: Radiation|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of TJ107 in Lympopenic Patients With Newly Diagnosed Glioblastoma Who Completed Standard Concurrent Chemoradiotherapy (CCRT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Newly Diagnosed Glioblastoma
Interventions: DRUG: TJ107|DRUG: TJ107 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aquatic Exercise and Reactive Balance
Status: NOT_YET_RECRUITING
Conditions: Aging|Aged|Accidental Falls|Postural Balance|Exercise|Exercise Therapy
Interventions: OTHER: Exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Antitumor Activity Trial of Immunoradiotherapy Combinations as a Treatment Option for Subjects With Metastatic Solid Tumors
Status: RECRUITING
Conditions: Non-CNS Tumor
Interventions: BIOLOGICAL: GEN1042|DRUG: Pembrolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Ziresovir in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Ziresovir|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Maveric Magnetic Resonance Imaging Used to Study Detailed Bone Apposition and Fixation of the Stryker Trident II Tritanium System
Status: COMPLETED
Conditions: Chronic Hip Pain
Interventions: DIAGNOSTIC_TEST: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Probiotic for Oral Health (PRO Health) Study
Status: COMPLETED
Conditions: Oral Microbiome
Interventions: DIETARY_SUPPLEMENT: Placebo-Control Supplement|DIETARY_SUPPLEMENT: Streptococcus-Containing Probiotic Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on Impact of Fentanyl Matrix on Improvement of Pain and Functioning in Spinal Disorder-related Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: fentanyl|DRUG: fentanyl|DRUG: fentanyl|DRUG: fentanyl|DRUG: fentanyl|DRUG: fentanyl|DRUG: fentanyl
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Negative Pressure Wound Therapy for the Prevention of Surgical Site Infection Following Lower Limb Revascularization
Status: UNKNOWN
Conditions: Surgical Wound Infection|Peripheral Vascular Diseases
Interventions: DEVICE: Prevena (Negative Pressure Wound Therapy Device)|DEVICE: Standard Tegaderm (3M Healthcare, St. Paul, MN) adhesive dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Effectiveness of an Intracranial Aneurysm Embolization System for Treating Large or Giant Wide Neck Aneurysms
Status: COMPLETED
Conditions: Brain Aneurysm
Interventions: DEVICE: Surpass Flow Diverter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation
Status: TERMINATED
Conditions: Irritable Bowel Syndrome With Constipation
Interventions: DRUG: Linaclotide Dose A|DRUG: Linaclotide Dose B|DRUG: Linaclotide Dose C|DRUG: Linaclotide Approved Adult Dose|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MGD019 DART® Protein in Unresectable/Metastatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Non Small Cell Lung Cancer|Prostate Cancer Metastatic|Cutaneous Melanoma|Colorectal Cancer|Advanced Cancer|Solid Tumor, Adult
Interventions: BIOLOGICAL: Lorigerlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natrunix Versus Methotrexate in Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Natrunix with MTX placebo (+folate)|DRUG: Natrunix placebo with MTX (+folate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel Followed by Radical Prostatectomy in Patients With High Risk Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Docetaxel|DRUG: Dexamethasone|DRUG: Estramustine|DRUG: Zoladex|DRUG: Casodex|PROCEDURE: Radical Prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Non-invasive ICP Monitoring in Patients Undergoing Invasive ICP Monitoring Via an External Ventricular Drainage (EVD) Device
Status: UNKNOWN
Conditions: Presence of High Intracranial Pressure
Interventions: DEVICE: EVD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Radiotherapy in Combination With Sintilimab，GM-CSF and Fruquintinib in Patients With MSS mCRC
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: RADIATION: hypofractionation Radiotherapy|DRUG: sintilimab|DRUG: GM-CSF|DRUG: Fruquintinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Single Dose, Open-Label Pharmacokinetic Study and Single-Blind, Placebo-Controlled Dose Escalation Study of NFC-1 in Adolescents With Attention-Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention-deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: NFC-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis
Status: COMPLETED
Conditions: Acute Otitis Externa
Interventions: DRUG: DPK-060|DRUG: Placebo for DPK-060 ear drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TENS in Reducing Symptoms of Peripheral Neuropathy Induced by Chemotherapy
Status: UNKNOWN
Conditions: Peripheral Neuropathy|Pain|Paresthesia|Neuritis
Interventions: DEVICE: active TENS|DEVICE: placebo TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
Status: RECRUITING
Conditions: Periodontal Diseases|Antibiotics|Pharmacokinetics
Interventions: DRUG: 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 7 days|DRUG: 3/d 500 mg Amoxicilline Sandoz plus 500 mg Flagyl for 3 days|DRUG: 1/d 500 mg Azithromycine Pfizer for 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: EUS-guided gallbladder drainage (EGBD)|PROCEDURE: Percutaneous cholecystostomy (PC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid-Free Orthopaedics
Status: RECRUITING
Conditions: Pain|Pain, Postoperative
Interventions: DRUG: Oxycodone 5 mg Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
Status: RECRUITING
Conditions: HIV Infections|Opioid Use
Interventions: DRUG: [18F]NOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Advanced Practice Physiotherapy Care in Emergency Departments
Status: NOT_YET_RECRUITING
Conditions: Musculoskeletal Diseases or Conditions|Emergency Department|Physiotherapy
Interventions: OTHER: Experimental: APP care|OTHER: Control - Usual physician care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Four-Drug Combination Treatment in Hiv-Infected Subjects Failing Therapy With Antiretroviral Regimens
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: capravirine|DRUG: Kaletra|DRUG: 2 NRTIs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Assess the Efficacy and Safety of Personalized Prophylaxis Human-cl rhFVIII in Patients With Severe Haemophilia A
Status: COMPLETED
Conditions: Severe Haemophilia A
Interventions: BIOLOGICAL: Human cl rhFVIII
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Decitabine, Vaccine Therapy, and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer
Status: COMPLETED
Conditions: Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer
Interventions: DRUG: decitabine|BIOLOGICAL: NY-ESO-1 peptide vaccine|DRUG: pegylated liposomal doxorubicin hydrochloride|BIOLOGICAL: sargramostim|BIOLOGICAL: incomplete Freund's adjuvant|OTHER: immunohistochemistry staining method|OTHER: liquid chromatography|OTHER: mass spectrometry|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: laboratory biomarker analysis|GENETIC: DNA methylation analysis|OTHER: enzyme-linked immunosorbent assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Multiple Dose Study to Evaluate the Pharmacology, Safety, and Tolerability of Patiromer in Participants on Hemodialysis
Status: TERMINATED
Conditions: Hyperkalemia
Interventions: DRUG: patiromer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Potentials of Preoperative Pregabalin,Magnesium Sulphate and Their Combination in Acute Post-thoracotomy Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Pregabalin & Placebo|DRUG: Magnesium sulphate & Placebo|DRUG: Pregabalin & Magnesium sulphate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of the Sentinel Cerebral Protection Device in Atrial Fibrillation Ablation
Status: RECRUITING
Conditions: Arrhythmia|Atrial Fibrillation
Interventions: DEVICE: Sentinel® Cerebral Protection System|DIAGNOSTIC_TEST: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Motivated Behavior in Adults With and Without ADHD
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: ADHD methylphenidate first, placebo second|DRUG: ADHD placebo first, methylphenidate second|DRUG: Non-ADHD methylphenidate first, placebo second|DRUG: Non-ADHD placebo first, methylphenidate second
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: KIDNET vs Meditation/Relaxation - a Dissemination Randomized Controlled Trial for the Treatment of Traumatized Children After War in Sri Lanka
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorders
Interventions: BEHAVIORAL: KIDNET|BEHAVIORAL: Meditation/Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TRE: Microbiome, Metabolic Health and Bone
Status: ACTIVE_NOT_RECRUITING
Conditions: Weight Loss|Time Restricted Feeding|Bone Loss
Interventions: BEHAVIORAL: Time Restricted Eating (TRE)|BEHAVIORAL: Calorie Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetic Study of Allegra in Pediatric Patients With Perennial Allergic Rhinitis (PAR)
Status: COMPLETED
Conditions: Rhinitis Perennial
Interventions: DRUG: fexofenadine/Allegra (M016455)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients
Status: RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DRUG: Pioglitazone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Nalmefene After Single Dose on the Blood Oxygen Level Dependent (BOLD) fMRI Signal in the Ventral Striatum to Reward Responding in the Monetary Incentive Delay Task (MIDT), in Non-treatment Seeking Subjects With Alcohol Dependence Following Alcohol Challenge
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Nalmefene 18 mg, then placebo|DRUG: Placebo, then Nalmefene 18 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer
Status: COMPLETED
Conditions: Recurrent Colon Carcinoma|Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Laryngeal Verrucous Carcinoma|Recurrent Lip and Oral Cavity Squamous Cell Carcinoma|Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Recurrent Oral Cavity Verrucous Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Recurrent Rectal Carcinoma|Recurrent Salivary Gland Carcinoma|Salivary Gland Squamous Cell Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7|Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7|Stage IVA Colon Cancer AJCC v7|Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Laryngeal Verrucous Carcinoma AJCC v7|Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVA Major Salivary Gland Cancer AJCC v7|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7|Stage IVA Oral Cavity Cancer AJCC v6 and v7|Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Rectal Cancer AJCC v7|Stage IVB Colon Cancer AJCC v7|Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Laryngeal Verrucous Carcinoma AJCC v7|Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVB Major Salivary Gland Cancer AJCC v7|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7|Stage IVB Oral Cavity Cancer AJCC v6 and v7|Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVB Rectal Cancer AJCC v7|Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7|Stage IVC Laryngeal Verrucous Carcinoma AJCC v7|Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7|Stage IVC Major Salivary Gland Cancer AJCC v7|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7|Stage IVC Oral Cavity Cancer AJCC v6 and v7|Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7|Tongue Carcinoma
Interventions: BIOLOGICAL: Cetuximab|OTHER: Laboratory Biomarker Analysis|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 99mTc-CNDG Injection in the Diagnosis of Malignant Tumors
Status: RECRUITING
Conditions: Malignant Tumor
Interventions: DIAGNOSTIC_TEST: 99mTc-CNDG SPECT/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Psychoeducational Intervention to Promote Adolescents' Mental Health Literacy in a School Context
Status: COMPLETED
Conditions: Health Literacy
Interventions: OTHER: Intervention ProLiSMentAl
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Esketamine Combined With Pregabalin on CPSP in Spinal Patients.
Status: NOT_YET_RECRUITING
Conditions: Esketamine|Pregabaline|Chronic Post Operative Pain
Interventions: DRUG: S-ketamine and pregabalin|DRUG: Normal saline and placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expansion Study to Evaluate the Efficacy and Safety of HM95573 in BRAF, KRAS or NRAS Mutant Solid Cancers
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: HM95573
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Transversalis Fascia Approach Versus Preperitoneal Space Approach for Inguinal Hernia Repair in Residents
Status: UNKNOWN
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Anterior transversalis fascia approach|PROCEDURE: Preperitoneal space approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy
Status: RECRUITING
Conditions: Progressive Multifocal Leukoencephalopathy
Interventions: BIOLOGICAL: Collection of blood and urine|BIOLOGICAL: Spinal tap|DIAGNOSTIC_TEST: Brain MRI|BIOLOGICAL: Neurological evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of V/Q Mismatch as Predictor of Pulmonary Postoperative Complications in Patients Undergoing Major Surgery
Status: COMPLETED
Conditions: Anesthesia|Postoperative Complications|Mechanical Ventilation Complication
Interventions: DEVICE: Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brain Stimulation for Concussion
Status: RECRUITING
Conditions: Transcranial Magnetic Stimulation|Magnetic Resonance Imaging|Neuropsychological Tests|Traumatic Brain Injury|Post-Concussion Syndrome
Interventions: DEVICE: Intermittent theta-burst treatment (iTBS) using MagPro Transcranial Magnetic Stimulator (manufacturer: Magventure)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Impact of Aripiprazole (Abilify®) Once Monthly Versus Standard of Care Oral Antipsychotic Medications on Changes in Brain Structure and Metabolism
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Standard of Care Oral antipsychotics|DRUG: IM aripiprazole once monthly|OTHER: No Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: On Probiotic, Dental Caries, and Orthodontic Patients
Status: UNKNOWN
Conditions: Dental Caries
Interventions: DIETARY_SUPPLEMENT: Active Probiotic|OTHER: Placebo Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: An Australian Study of Mesenchymal Stromal Cells for Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: Mesenchymal stromal cells (MSC) for infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of ACUVUE® OASYS® 1-Day and ACUVUE® OASYS®
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Senofilcon A contact lenses with HydraLuxe™|DEVICE: Senofilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimetrexate glucuronate|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Varying Regimens of CANDIN for Treatment of Common Warts (Verruca Vulgaris)
Status: COMPLETED
Conditions: Warts
Interventions: BIOLOGICAL: CANDIN|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients
Status: SUSPENDED
Conditions: Vitamin D Deficiency|Polytrauma|Orthopedic Disorder
Interventions: DRUG: Ergocalciferol 8000 IU/ML Oral Liquid [DRISDOL]|DRUG: Propylene Glycol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Post-SCI Hypotension
Status: COMPLETED
Conditions: Spinal Cord Injury|Autonomic Dysreflexia|Orthostatic Hypotension|Baroreceptor Integrity|Sympathetic Integrity|Vagal Integrity|Hypotension|Cerebral Blood Flow|Blood Pressure|Venous Occlusion Plethysmography
Interventions: DRUG: Midodrine Hydrochloride|DRUG: Midodrine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Solosec® for the Treatment of Trichomoniasis
Status: COMPLETED
Conditions: Trichomonas Infection
Interventions: DRUG: Secnidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir-Containing Regimens Without Interferon For Treatment of Acute Hepatitis C Virus (HCV) Infection
Status: COMPLETED
Conditions: HIV-1 Infection|Hepatitis
Interventions: DRUG: Sofosbuvir|DRUG: Ribavirin|DRUG: Ledipasvir/Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Supine Hypertension in Autonomic Failure
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Clonidine|DRUG: Nitroglycerin transdermal|DRUG: Dipyridamole/ Aspirin (Aggrenox)|DRUG: Desmopressin (DDAVP)|DRUG: Sildenafil|DRUG: Nifedipine|DRUG: Hydralazine|DRUG: Hydrochlorothiazide|DRUG: Placebo|DRUG: Bosentan|DRUG: Diltiazem|DRUG: Eplerenone|DRUG: guanfacine|DIETARY_SUPPLEMENT: L-arginine|DRUG: captopril|DRUG: carbidopa|DRUG: losartan|DRUG: metoprolol tartrate|DRUG: nebivolol hydrochloride|DRUG: prazosin hydrochloride|DRUG: tamsulosin hydrochloride|OTHER: Head-up tilt.|DRUG: aliskiren|OTHER: Local heat stress
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer|Locally Advanced
Interventions: DRUG: Chemotherapy With FOLFIRINOX ( 5 Fluorouracil, Oxaliplatine and Irinotecan)|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Combined SGT-53 Plus Gemcitabine/Nab-Paclitaxel for Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Metastatic Pancreatic Cancer
Interventions: GENETIC: SGT-53|DRUG: nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community-based Rehabilitation Management for Patients With Remitted Geriatric Depression
Status: NOT_YET_RECRUITING
Conditions: Geriatric Depression
Interventions: COMBINATION_PRODUCT: CBRM (community-based rehabilitation management)|COMBINATION_PRODUCT: TAR(treatment as routine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
Status: RECRUITING
Conditions: Systemic Sclerosis Associated Interstitial Lung Disease|Scleroderma, Systemic
Interventions: BIOLOGICAL: Belimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Demodex Blepharitis Treatment Study
Status: COMPLETED
Conditions: Chronic Blepharitis
Interventions: DRUG: Terpinen-4-ol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT