pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Observational Clinical Study on Elderly Patients With Fracture of the Proximal Femur Treated With the Chimaera Nail
Status: UNKNOWN
Conditions: Hip Fractures|Subtrochanteric Fractures|Intertrochanteric Fractures|Pertrochanteric Fracture
Interventions: DEVICE: Chimaera short nail (length = 180 mm) in combination with one or two telescopic cephalic screws
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Cognitive Orientation Approach on Daily Occupational Performance With Autism Spectrum Disorder
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Executive Function|Patient Participation
Interventions: BEHAVIORAL: Cognitive Orientation Approach|BEHAVIORAL: Ayres Sensory Integration Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PD-1 Inhibitor Sintilimab Combined With Capecitabine for Adjuvant Treatment After Radical Resection of Cholangiocarcinoma.
Status: NOT_YET_RECRUITING
Conditions: Cholangiocarcinoma
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identify the Prosthesis Users' Necessities Concerning Their Devices.
Status: ENROLLING_BY_INVITATION
Conditions: Upper Limb Amputation at the Hand
Interventions: OTHER: Technology acceptance questionnaire for prostheses users.|OTHER: Technology acceptance questionnaire for relatives of prostheses users.|OTHER: Technology acceptance questionnaire for therapists
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaccine Therapy and Pembrolizumab in Treating Patients With Hormone-Resistant, Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Hormone-Resistant Prostate Cancer|Metastatic Malignant Neoplasm in the Bone|Metastatic Malignant Neoplasm in the Soft Tissues|Metastatic Prostate Carcinoma|Prostate Adenocarcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer
Interventions: BIOLOGICAL: Pembrolizumab|BIOLOGICAL: pTVG-HP Plasmid DNA Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How BI 1291583 is Processed in the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1291583 mixed with [C-14] BI 1291583
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obesity Treatment With a Very Low Energy Diet in Mexican Adults
Status: RECRUITING
Conditions: Obesity|Weight Loss
Interventions: OTHER: Intensive lifestyle change program with a very-low-energy diet|OTHER: Intensive lifestyle change program with a low-energy diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 Antibody Combined With Autologous DC and NK Cells in the Treatment of Digestive Carcinoma
Status: NOT_YET_RECRUITING
Conditions: PD-1 Antibody|DC-Cell|NK-Cell|Gastrointestinal Tumours
Interventions: DRUG: Pembrolizumab|DRUG: Nivolumab|DRUG: Sintilimab|DRUG: Toripalimab|DRUG: Camrelizumab|DRUG: Tislelizumab|BIOLOGICAL: NK-Cell or DC-Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Fructose/Glucose-rich Diet on Brown Fat in Healthy Subjects (GB7)
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Diet|OTHER: cold exposure|RADIATION: 18FDG|RADIATION: 11C-acetate|RADIATION: [3-3H]-glucose|OTHER: [U-13C]-palmitate|OTHER: 2H-Glycerol|DEVICE: MRI/MRS|DEVICE: Electromyogram (EMG)|DEVICE: DXA|DEVICE: Indirect calorimetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Detection of Autologous DEHP (DiEthylHexyl Phthalate)-Free Blood Transfusion in Anti-doping
Status: COMPLETED
Conditions: Transfusion Reaction
Interventions: BIOLOGICAL: Autologous blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate D-1553 in Subjects With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult|NSCLC|CRC
Interventions: DRUG: D-1553|DRUG: D-1553 in combination with Drug: pembrolizumab, Drug:KEYTRUDA® , Drug: cetuximab, Drug: other
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Aprepitant (Emend®) in Children
Status: COMPLETED
Conditions: Nausea|Vomiting|Childhood Cancer
Interventions: DRUG: Ondansetron, dexamethasone, aprepitant|DRUG: Ondansetron, Dexamethasone, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Exenatide for Myocardial Protection During Reperfusion Study
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subthreshold Laser Treatment for Reticular Pseudodrusen Secondary to Age-related Macular Degeneration
Status: RECRUITING
Conditions: Macular Degeneration, Senile|Laser Burn of Retina|Macular Degeneration Intermediate|Macular Degeneration, Dry
Interventions: DEVICE: Pascal Synthesis 577 sub-threshold laser (Topcon Corporation, Tokyo, Japan)|DEVICE: Pascal Synthesis 577 sham (Topcon Corporation, Tokyo, Japan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Vitamin D Supplementation in Elderly Women
Status: COMPLETED
Conditions: Optimal Vitamin D Administration
Interventions: DIETARY_SUPPLEMENT: vitamin D twice daily|DIETARY_SUPPLEMENT: Vitamin D3 oil three times in a year
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remembering Risk Using Visual Risk Display of MINS to Obtain Informed Consent to Undergo Elective Surgery
Status: UNKNOWN
Conditions: Risk
Interventions: OTHER: Visual Aid|OTHER: Scripted Risk Discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Neoadjuvant Treatment of Fruquintinib Combined With Concurrent Chemoradiotherapy for LARC
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: fruquintinib + concurrent radiotherapy + chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II
Status: COMPLETED
Conditions: Sickle Cell Disease|Stroke
Interventions: DRUG: Hydroxyurea (Moderate Dose)|DRUG: Hydroxyurea (Low Dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biological Standardization of Dactylis Glomerata Allergen Extract
Status: COMPLETED
Conditions: Allergy to Grass Pollen (Dactylis Glomerata)
Interventions: BIOLOGICAL: Four different concentrations of Dactylis glomerata allergen extract, positive control and negative control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Polyvalent Vaccine-KLH Conjugate + Opt-821 Given in Combination With Bevacizumab
Status: COMPLETED
Conditions: Fallopian Tubes Cancer|Ovarian Cancer|Peritoneal Cancer
Interventions: BIOLOGICAL: bevacizumab and the polyvalent vaccine-KLH conjugate + OPT-821
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TLIF Osteo3 ZP Putty Study (Also Known as the TOP Fusion Study)
Status: COMPLETED
Conditions: Degenerative Disc Disease|Degenerative Spondylolisthesis|Lumbar Spinal Stenosis
Interventions: DEVICE: Osteo3 ZP Putty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Inspiratory Muscle Training in Patients With Heart Failure and Obstructive Sleep Apnea Syndrome
Status: UNKNOWN
Conditions: Chronic Heart Failure
Interventions: OTHER: Inspiratory muscle training (IMT)|OTHER: Sham IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-term Testosterone Replacement in Testicular Cancer Survivors
Status: COMPLETED
Conditions: Testicular Cancer
Interventions: DRUG: Androgel (Testosterone gel)|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SubArachnoid Hemorrhage HEadache Treated by Lumbar Puncture
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage|Headache
Interventions: PROCEDURE: Lumbar puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: the Effectivness of the Thoracic Cage Mobilization on COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: conventional treatment|OTHER: thoracic mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of TA-650 in Patients With Refractory Kawasaki Disease
Status: COMPLETED
Conditions: Kawasaki Disease Refractory to Initial Therapy With Intravenous Immunoglobulin
Interventions: DRUG: TA-650|DRUG: Polyethylene Glycol-treated Human Immunoglobulin (VGIH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cinnamomum Supplementation in Chronic Kidney Disease Patients
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: cinnamomum|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tobramycin Tear Concentrations
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: TOBRADEX Ophthalmic Suspension|DRUG: Tobramycin 0.3% / Dexamethasone 0.05% Ophthalmic Suspension|DRUG: TOBREX Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Lansoprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of COVID-19 Protein Subunit Recombinant Vaccine
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 protein subunit recombinant vaccine|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Preliminary Efficacy of a Reverse Diet as a Novel Weight Loss Maintenance Strategy for Weight-Reduced Adults With Overweight/Obesity
Status: COMPLETED
Conditions: Overweight and Obesity|Weight Loss Maintenance|Dietary Habits
Interventions: BEHAVIORAL: Weight Loss Maintenance (Control vs. Reverse Diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Patient-Specific Computational Walking Models in Improving Surgical and Rehabilitation Treatment in Patients With Pelvic Sarcomas
Status: RECRUITING
Conditions: Pelvic Sarcoma
Interventions: OTHER: Functional Assessment|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Booster Superiority Study of PTX-COVID19-B Compared to Vaxzevria® in Adults Aged 18 Years and Older
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: PTX-COVID19-B|BIOLOGICAL: Vaxzevria®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Accuracy of Reconstruction of Orbital Walls Fracture Using Prebent Mesh Versus Patient Specific Implant
Status: ENROLLING_BY_INVITATION
Conditions: Orbital Fractures
Interventions: DEVICE: reconstruction of orbital walls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Conventionally vs. Digitally Fabricated Complete Dentures: Clinical Treatment Outcome Differences
Status: WITHDRAWN
Conditions: Mouth, Edentulous
Interventions: DEVICE: Complete traditional dentures|DEVICE: Complete CADCAM dentures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Outcomes of Hypertension in Obese Versus Non-obese Pregnant Women
Status: NOT_YET_RECRUITING
Conditions: Hypertension in Pregnancy
Interventions: DRUG: Anti-Hypertensive|RADIATION: Ultrasound|RADIATION: Doppler ultrasound|DIAGNOSTIC_TEST: complete blood count|DIAGNOSTIC_TEST: Body mass index
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Control of Postprandial Hyperglycemia
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: High-carbohydrate diet|BEHAVIORAL: Low-carbohydrate diet|BEHAVIORAL: Low-carbohydrate diet with post-meal walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating Therapy
Status: RECRUITING
Conditions: MRI Scans
Interventions: RADIATION: Quantitative Susceptibility Mapping (QSM) Magnetic Resonance Imaging (MRI)|RADIATION: R2* Magnetic Resonance Imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Betaseron 16-Year Long-Term Follow-Up (LTF) in Patients With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon beta-1b (Betaseron, BAY86-5046)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Adaptive Dose Painting by Numbers With Standard Radiotherapy for Head and Neck Cancer.
Status: COMPLETED
Conditions: Primary Non-operated Squamous Cell Carcinoma of Oral Cavity|Primary Non-operated Squamous Cell Carcinoma of Oropharynx|Primary Non-operated Squamous Cell Carcinoma of Hypopharynx|Primary Non-operated Squamous Cell Carcinoma of Larynx
Interventions: RADIATION: Adaptive dose-painting-by-numbers|RADIATION: standard intensity-modulated radiotherapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Cessation of Pomegranate Juice Intake on Inflammation and Oxidative Stress Markers and Glucose Control in Diabetic and Non Diabetic Chronic Hemodialysis Patients
Status: COMPLETED
Conditions: Inflammation|Oxidative Stress
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nanochip Technology in Monitoring Treatment Response and Detecting Relapse in Participants With Diffuse Large B-Cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type|Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|High Grade B-Cell Lymphoma
Interventions: PROCEDURE: Molecular Nanotechnology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Follicular Lymphoma (FL)|CLL|Small Lymphocytic Lymphoma (SLL)|Richter's Syndrome|Mantle Cell Lymphoma (MCL)|Indolent Non Hodgkin Lymphoma|Waldenström Macroglobulinemia|Multiple Myeloma|Hodgkin Lymphoma|Burkitt Lymphoma|Marginal Zone Lymphomas|Mediastinal Large B Cell Lymphoma|Hairy Cell Leukemia
Interventions: DRUG: Acalabrutinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅱ Dose-escalating Study of PEG-IFN-SA and Ribavirin in IFN Naive Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: PEG-IFN-SA /RBV low dose|DRUG: PEG-IFN-SA /RBV middle dose|DRUG: PEG-IFN-SA /RBV high dose|DRUG: Pegasys /RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D Mitral Anuloplasty Ring
Status: COMPLETED
Conditions: Mitral Valve Disease
Interventions: DEVICE: MEMO 3D ring|DEVICE: Standard use of rigid ring.|PROCEDURE: 3D Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Bioavailability and Adhesion Performance Study, Comparing a New Scopolamine Transdermal Delivery System Formulation to the Currently Established Reference Transdermal Delivery System in Healthy Adult Participants.
Status: COMPLETED
Conditions: Motion Sickness
Interventions: DRUG: Reformulated scopolamine patch|DRUG: Marketed scopolamine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis
Status: RECRUITING
Conditions: Radiation Mucositis
Interventions: DIETARY_SUPPLEMENT: Manuka honey mixed with aloe vera gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Augmentation of Cognitive Training in Children With TBI With D-Cyloserine
Status: UNKNOWN
Conditions: Traumatic Brain Injury
Interventions: DRUG: D-Cycloserine|BEHAVIORAL: Cogmed Working Memory Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Response of Ultrasound and Muscular Stretching in Temporomandibular Disorder Patients
Status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Interventions: OTHER: Ultrasound|OTHER: Ultrasound associated with stretching|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adolescent Sexually Transmitted Infection Screening in the Emergency Department
Status: ACTIVE_NOT_RECRUITING
Conditions: Gonorrhea|Chlamydia
Interventions: OTHER: Targeted STI Screening|OTHER: Universally Offered STI Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Comparison of the Outcomes of Distal Fingertip Amputations Treated With Either Artificial (Xeroform) or Biological Dressings
Status: WITHDRAWN
Conditions: Finger Injuries|Amputation, Traumatic
Interventions: OTHER: Bacitracin|OTHER: Skin Graft
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mesenchymal Stem/Stromal Cell Therapy in the Treatment of Frailty
Status: ACTIVE_NOT_RECRUITING
Conditions: Frailty
Interventions: BIOLOGICAL: Umbilical Cord Mesenchymal Stem Cells transplantation|DRUG: standard frailty treatment and supplementary medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of SkQ1 as Treatment for Dry-eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Low Dose - SkQ1|DRUG: High dose - SkQ1|DRUG: SkQ1 (Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids
Status: COMPLETED
Conditions: Heavy Uterine Bleeding|Uterine Fibroids
Interventions: DRUG: Elagolix|DRUG: Placebo|DRUG: Estradiol/Norethindrone acetate (E2/NETA)|DRUG: Estradiol|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia
Status: COMPLETED
Conditions: Aplastic Anemia
Interventions: DRUG: Mycophenolate mofetil|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of ESWL Alone and ESWL + Endoscopy for Painful Chronic Pancreatitis
Status: COMPLETED
Conditions: Pancreatitis
Interventions: PROCEDURE: Extracorporeal shock wave lithotripsy|PROCEDURE: Endoscopic drainage of the main pancreatic duct
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Trial of CERC-501 Augmentation of Antidepressant Therapy in Treatment-Resistant Depression
Status: TERMINATED
Conditions: Treatment Resistant Depression
Interventions: DRUG: CERC-501|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 12-Week Home-Based Electrical Stimulation Program for Strength in Adults With Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis|Osteoarthritis, Knee
Interventions: OTHER: 12-week exercise and walking program|DEVICE: NMES|DEVICE: FES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
Status: COMPLETED
Conditions: Pain, Postoperative|Thoracic|Acute Pain
Interventions: DRUG: Liposomal Bupivacaine|DRUG: Bupivacaine, 0.25%|DRUG: Bupivacaine, 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALK33-101: A Study of RDC-0313 (ALKS 33) in Adults With Binge Eating Disorder
Status: COMPLETED
Conditions: Binge Eating Disorder
Interventions: DRUG: RDC-0313 (ALKS 33)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effects of Constraint-Induced Movement Therapy on Young Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy Spastic Hemiplegic
Interventions: OTHER: Constraint-induced movement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Dupilumab for the Treatment of Patients With Prurigo Nodularis, Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable (LIBERTY-PN PRIME)
Status: COMPLETED
Conditions: Neurodermatitis
Interventions: DRUG: Dupilumab SAR231893|DRUG: Placebo|DRUG: Moisturizers|DRUG: Low to medium potent topical corticosteroids|DRUG: Topical calcineurin inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Atomization of Ropivacaine During Gynecologic Laparoscopic Surgery
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine|DRUG: placebo (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cannabidiol (CBD) on Resting-state Electroencephalography (EEG) and Neuropathic Pain Severity in People With Spinal Cord Injury (SCI)
Status: NOT_YET_RECRUITING
Conditions: SCI - Spinal Cord Injury|Neuropathic Pain
Interventions: DRUG: CBD|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Myofascial Release on Dysphagia in Parkinson's Patients
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Rehabilitation treatment|BEHAVIORAL: Myofascial Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effects of High-intensity and Moderate-intensity Exercise on Polycystic Ovary Syndrome
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome|Exercise|Cerebrovascular Circulation
Interventions: OTHER: High-Intensity Exercise|OTHER: Moderate-Intensity Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Velcade-Melphalan-Prednisone in Older Untreated Multiple Myeloma Patients.
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade|DRUG: Melphalan|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients
Status: UNKNOWN
Conditions: Pain|Opioid Tolerance|Analgesia Tolerance
Interventions: DRUG: Dextromethorphan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of the Baska Mask Airway to a Single-use LMA Device in Low-risk Female Patients
Status: COMPLETED
Conditions: Performance and Safety of an Airway Management Device
Interventions: DEVICE: supraglottic airway placement and use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cough Reduction in IPF With Nalbuphine ER
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: nalbuphine ER 27 mg|DRUG: Placebo|DRUG: nalbuphine ER 54 mg|DRUG: nalbuphine ER 108 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Community Partnership for Telehealth Solutions to Counter Misinformation and Achieve Equity
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: BEHAVIORAL: Video text message|BEHAVIORAL: In-clinic CRC screening promotion|BEHAVIORAL: Mailed FIT|BEHAVIORAL: Social needs navigation|BEHAVIORAL: Reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: Monalizumab|DRUG: Durvalumab|DRUG: Cetuximab|DRUG: mFOLFOX6|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors
Status: RECRUITING
Conditions: Tumor, Solid|Pancreatic Cancer|Melanoma
Interventions: DRUG: Ulixertinib|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myocardial Infarction in the Perioperative Setting
Status: COMPLETED
Conditions: Myocardial Infarction Postoperative|Myocardial Injury|Intraoperative Complications|Intraoperative Hypotension|Peroperative Complication
Interventions: PROCEDURE: Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DP303c in Patients With HER2-positive Advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Advanced Breast Cancer
Interventions: DRUG: DP303c|DRUG: Trastuzumab|DRUG: Vinorelbine Tartrate|DRUG: Capecitabine tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH)
Status: RECRUITING
Conditions: Gram-negative Bacterial Infection
Interventions: DRUG: Part A: ATM-AVI Single Dose, Cohorts 1-4|DRUG: Part B: Multiple-dose ATM-AVI, Cohorts 1-4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Axon Therapy for Post-Traumatic Peripheral Neuropathic Pain Compared to Conventional Medical Management
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuropathic Pain|Peripheral Neuropathy
Interventions: DEVICE: CMM + Axon Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remineralization Potential of Ginger and Rosemary Herbals Versus Sodium Fluoride in Treatment of White Spot Lesions
Status: UNKNOWN
Conditions: White Spot Lesions
Interventions: OTHER: ginger and rosemary gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts
Status: COMPLETED
Conditions: Tinnitus
Interventions: DEVICE: Burst-SCS/sham SCS|DEVICE: Sham SCS/Burst-SCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immediate Postoperative Course of Patients With Mini Video Assisted Total Thyroidectomy (miVAT) Versus Classic Total Thyroidectomy (cTT)
Status: COMPLETED
Conditions: Goiter
Interventions: PROCEDURE: Total Thyroidectomy (Mini Video Assisted Thyroidectomy)|PROCEDURE: Total Thyroidectomy (Classic Thyroidectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of Colon Capsule Endoscopy in Colon Cancer Screening
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: DEVICE: Pillcam® COLON 2 Capsule|PROCEDURE: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Clinical Trial Study to Determine the Effect of an Investigational Drug (SEP-363856) Has on the Way That the Drug Metformin Travels Through the Body in People With Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: placebo|DRUG: SEP-363856|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma
Status: TERMINATED
Conditions: Intracranial Meningioma
Interventions: DRUG: Everolimus|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Escalating Dose Study in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia
Status: COMPLETED
Conditions: B Cell Non-Hodgkin's Lymphoma|Chronic Lymphocytic Leukemia|Waldenstrom Macroglobulinemia
Interventions: DRUG: AVL-292
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Acute Kidney Injury (AKI) in Pediatric Patients
Status: UNKNOWN
Conditions: Acute Kidney Injury
Interventions: DRUG: Aminophylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Insulin Glulisine and Aspart in Postprandial Glycemic Control After High-GI Meal in Children With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin glulisine|DRUG: Insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Permeaderm Versus Homograft for Full-thickness Burns
Status: WITHDRAWN
Conditions: Full Thickness Burn
Interventions: DEVICE: PermeaDerm for temporary coverage|DEVICE: FHCA for temporary coverage|DEVICE: PermeaDerm over autograft|DEVICE: FHCA over autograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Pembrolizumab for the Treatment of Recurrent and/or Metastatic Salivary Gland Cancer
Status: RECRUITING
Conditions: Metastatic Salivary Gland Carcinoma|Recurrent Salivary Gland Carcinoma|Stage IV Major Salivary Gland Cancer AJCC v8|Adenoid Cystic Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Pemetrexed Disodium|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Positron Emission Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: PSMA PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-operative Analgesia in Elective, Soft-tissue Hand Surgery
Status: TERMINATED
Conditions: Carpal Tunnel|Ganglion Cyst|Trigger Finger|De Quervain Disease
Interventions: DRUG: Acetaminophen/Ibuprofen|DRUG: Acetaminophen/Hydrocodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Lactoferrin, a Dietary Supplement, vs. Placebo on Respiratory Tract Infections
Status: COMPLETED
Conditions: Immune Health
Interventions: DIETARY_SUPPLEMENT: Control: Placebo|DIETARY_SUPPLEMENT: bovine lactoferrin supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: PillCam® Platform With the PillCam Crohn's Disease Capsule
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: OTHER: Pillcam colon capsule and PillCam™ Prep Procedure|DEVICE: Ileocolonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Tissue Sodium in Autoimmune Disease
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus
Interventions: DIETARY_SUPPLEMENT: Low Dietary Sodium|DIETARY_SUPPLEMENT: High Dietary Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3023414 Formulations and the Effect of Food
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3023414 Reference Fasted|DRUG: LY3023414 Test Fasted|DRUG: LY3023414 Test Fed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Finafloxacin 300 mg Twice a Day (b.i.d.) Versus Ciprofloxacin 250 mg Twice a Day (b.i.d) in Patients With Lower Uncomplicated UTI (uUTI)
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Finafloxacin|DRUG: Ciprofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Wharton Jelly in Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction Associated With Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: Wharton Jelly Mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit
Status: COMPLETED
Conditions: Ulcer
Interventions: DRUG: esomeprazole 40 mg|DRUG: famotidine 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of Rituximab for Graves' Ophthalmopathy
Status: COMPLETED
Conditions: Thyroid-associated Ophthalmopathy
Interventions: DRUG: Rituximab|DRUG: Saline|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Dose-Response Relationship of Multiple Doses of GSK2269557 Administered as a Dry Powder to Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK2269557 100 MCG|DRUG: GSK2269557 500 MCG|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Folate vs. Synthetic Folic Acid in Pregnancy
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Folic acid|DIETARY_SUPPLEMENT: (6S)-5-methyltetrahydrofolic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Allogeneic Bone Marrow Transplantation for the Treatment of Genetic Disorders of Erythropoiesis
Status: COMPLETED
Conditions: Genetic Disorders|Sickle Cell Anemia
Interventions: PROCEDURE: Busulfan, Cyclophosphamide, BMD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Immunogenicity of Ad35.RSV.FA2 Regimens Boosted With Ad26.RSV.FA2 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: BIOLOGICAL: Ad35.RSV.FA2|BIOLOGICAL: Ad26.RSV.FA2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Pencil Beam Proton Therapy for Recurrences in Anal Cancer Patients Previously Treated With Radiotherapy (DACG 5)
Status: RECRUITING
Conditions: Anal Cancer|Recurrent Anal Cancer
Interventions: RADIATION: Pencil beam proton therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Ability to Produce Immune Response of Prevenar and Meningitec Given at the Same Time
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Prevenar and Meningitec|BIOLOGICAL: Prevenar|BIOLOGICAL: Meningitec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The BD Odon DeviceTM for Assisted Vaginal Birth: a Feasibility Study to Investigate Safety and Efficacy
Status: UNKNOWN
Conditions: Pregnant Woman
Interventions: DEVICE: The BD Odon DeviceTM is a new device for AVB that has been designed by a team of midwives, doctors and engineers.|PROCEDURE: forceps or ventouse
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Feasibility Study of a Sjögren's Syndrome Self-management App
Status: UNKNOWN
Conditions: Sjogren's Syndrome
Interventions: BEHAVIORAL: Self-management app with all intervention components|BEHAVIORAL: Self-management app with Information component only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Evacetrapib (LY2484595) in Japanese Participants With Primary Hypercholesterolemia
Status: TERMINATED
Conditions: Hypercholesterolemia
Interventions: DRUG: Evacetrapib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events
Status: RECRUITING
Conditions: Intracerebral Hemorrhage|CAA - Cerebral Amyloid Angiopathy|Cerebral Small Vessel Diseases
Interventions: DIAGNOSTIC_TEST: Combined 3- and 7 Tesla-MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Central Versus Peripheral Vestibular Stimulation in Patients With Peripheral Vestibular Disorders
Status: RECRUITING
Conditions: Peripheral Vestibular Disorders
Interventions: DEVICE: repetitive transcranial magnetic stimulation|DEVICE: Galvanic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adherence and Outcomes in Functional Constipation With a Constipation Action Plan
Status: COMPLETED
Conditions: Adherence, Medication|Functional Constipation|Pediatric ALL|Survey, Family Life
Interventions: BEHAVIORAL: Action Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Randomized Controlled, H1 Coil In Subjects With Bipolar Depression
Status: UNKNOWN
Conditions: Bipolar Depression
Interventions: DEVICE: H-Coil deep TMS|DEVICE: sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Gemcitabine in Hormonal Refractory Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Dose Requirements of Rocuronium Bromide (Zemuron®) in Pediatric and Adolescent Subjects (21048)(COMPLETED)(P05797)
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Rocuronium bolus maintenance|DRUG: rocuronium continuous infusion maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Psycho-education on Gestational Weight Gain and Anxiety/Depression in Obese Pregnant Women
Status: UNKNOWN
Conditions: Obese Pregnant Women
Interventions: BEHAVIORAL: Lifestyle counseling|OTHER: brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)
Status: UNKNOWN
Conditions: Acute Brain Injury
Interventions: PROCEDURE: Airway Management Pathway|PROCEDURE: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dietary Intervention in Patients With a History of Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DIETARY_SUPPLEMENT: Dietary Intervention|DIETARY_SUPPLEMENT: Dietary Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Identification of Anticancer Drugs Associated With Cancer Therapy-related Cardiac Dysfunction: a Pharmacovigilance Study
Status: COMPLETED
Conditions: Heart Failure|Cancer, Therapy-Related
Interventions: DRUG: Cancer therapy with FDA and/or European Medicines Agency approval on the 30th September 2023
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p