pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combined Therapy With L-Thyroxine and L-Triiodothyronine Compared to L-Thyroxine Alone
Status: COMPLETED
Conditions: Hypothyroidism
Interventions: DRUG: thyroxine|DRUG: thyroxine and triiodothyronine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin A on Atherosclerosis
Status: UNKNOWN
Conditions: Atherosclerosis
Interventions: DRUG: Vitamin A|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery
Status: COMPLETED
Conditions: One-Lung Ventilation|Thoracic Surgery
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Outcomes of Cognitive Behavioral Therapy (CBT) for Battered Women With Posttraumatic Stress Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Cognitive Trauma Therapy for Battered Women (CTT-BW)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Biology and Experience of Eating in Women With Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Naloxone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
Status: RECRUITING
Conditions: Respiratory Failure|Anxiety|Critical Illness
Interventions: BEHAVIORAL: Cognitive behavioral therapy based self-management for anxiety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum
Status: NOT_YET_RECRUITING
Conditions: HIV
Interventions: BIOLOGICAL: CD4BS CH505M5 Pr-NP1|BIOLOGICAL: CH505TF chTrimer|BIOLOGICAL: 3M-052-AF (labeled as AP 60-702)|BIOLOGICAL: Aluminum Hydroxide Suspension (Alum)|BIOLOGICAL: ACU-026-001-1 (labeled as empty LNP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improving Infant Nutrition in Southern Ethiopia
Status: COMPLETED
Conditions: Nutrition Disorders
Interventions: BEHAVIORAL: Orange Fleshed Sweet Potato (OFSP) agriculture promotion and nutrition education on vitamin A intake|BEHAVIORAL: Healthy Baby Toolkit|BEHAVIORAL: Standart of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: BiOSS LIM C vs 2nd Generation DES in Non-LM Bifurcations
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Percutaneous Coronary Intervention with stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LED Therapy for the Treatment of Concussive Brain Injury
Status: COMPLETED
Conditions: Brain Concussion
Interventions: DEVICE: MedX Health Console model 1100|DEVICE: MedX Health Console model 1100-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO)
Status: COMPLETED
Conditions: Macular Edema Secondary to Central Retinal Vein Occlusion
Interventions: BIOLOGICAL: VEGF Trap-Eye 2.0mg|DRUG: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Radiofrequency Ablation System in the Treatment of Peripheral Lung Tumors
Status: COMPLETED
Conditions: Lung Neoplasms|Pulmonary Metastasis
Interventions: DEVICE: Pulmonary Radiofrequency Ablation System and the Disposable Pulmonary Radiofrequency Ablation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors
Status: WITHDRAWN
Conditions: Non-muscle Invasive Bladder Cancer (NMIBC)|Bladder Tumor (TURBT)
Interventions: PROCEDURE: CBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scaling Up: A Multi-Site Trial of e-SBI for Alcohol Use in Pregnancy
Status: RECRUITING
Conditions: Fetal Alcohol Spectrum Disorders|Fetal Alcohol Syndrome|Fetal Alcohol Effect
Interventions: OTHER: General information|BEHAVIORAL: Baseline brief intervention|BEHAVIORAL: Remote online booster sessions|BEHAVIORAL: SMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety & Efficacy of Pilocarpine Eye Solutions for Temporary Improvement of Near Vision in Presbyopic Adults
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: Pilocarpine Ophthalmic|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinetics of B-Cell Responses to Live, Attenuated Influenza Vaccine (LAIV) in Young Children Two Years of Age
Status: TERMINATED
Conditions: Influenza
Interventions: BIOLOGICAL: 2008-2009 FluMist LAIV (Intranasal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy Study of 2',3'-Dideoxyinosine (ddI) (BMY-40900) Administered Orally Twice Daily to Zidovudine Intolerant Patients With AIDS or AIDS-Related Complex
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection
Status: UNKNOWN
Conditions: Spinal Cord Injury at C5-Th10 Level With Complete Lesion|Spinal Cord Transection
Interventions: PROCEDURE: obtaining of autologous human olfactory bulb, autologous sural nerve preparation|BIOLOGICAL: production of Glial Neuropatch|PROCEDURE: microsurgical reconstruction of the transected spinal cord with autologous Glial Neuropatch-nerve bridges
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RT-01 Monotherapy and in Combination With Nivolumab in Patients With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Advanced Solid Tumor
Interventions: BIOLOGICAL: Oncolytic Virus Injection (RT-01）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supporting Family Caregivers of Persons Living With Dementia: Effectiveness and Sustainability of MT4C-In Care
Status: COMPLETED
Conditions: Dementia|Family
Interventions: BEHAVIORAL: My Tools for Care - In Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PACE: PD-1 Antibody For dMMR/MSI-H Stage III Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Carcinoma
Interventions: DRUG: Sintilimab|DRUG: Oxaliplatin|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Finding Study of S.Pneumoniae Whole Cell Vaccine Adsorbed to Alum (PATH-wSP) in Healthy Kenyan Adults and Toddlers
Status: COMPLETED
Conditions: Pneumonia, Pneumococcal
Interventions: BIOLOGICAL: PATH-wSP|BIOLOGICAL: Synflorix|BIOLOGICAL: Pentavac|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Chimeric Antigen Receptor T Cell Redirected to Target CD4 Positive Relapsed Refractory Acute Myeloid Leukemia (AML ) as a Bridge to Allogeneic Stem Cell Transplant
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: CD4CAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultra-early STatin in Patients With Aneurysmal subaRachnoid Hemorrhage (Ue-STAR)
Status: NOT_YET_RECRUITING
Conditions: Subarachnoid Hemorrhage|Subarachnoid Hemorrhage, Aneurysmal|Aneurysmal Subarachnoid Hemorrhage|Hemorrhage, Aneurysmal Subarachnoid
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of TAP Block in the Control of Postoperative Pain After Laparotomy for Gynecological Procedures
Status: UNKNOWN
Conditions: Leiomyoma|Pelvic Organ Prolapse|Abnormal Uterine Bleeding|Chronic Pain|Premalignant Lesion|Endometriosis
Interventions: DRUG: Systemic multimodal analgesia administered intravenously|PROCEDURE: Transversus abdominis plane block (TAP block)|OTHER: Combined transversus abdominis plane block (TAP block) with systemic multimodal analgesia administered intravenously
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Furmonertinib Combined With Anlotinib in Lung Adenocarcinoma Patients With EGFR Mutations and Brain Metastases
Status: NOT_YET_RECRUITING
Conditions: Adenocarcinoma of Lung Metastatic to Brain
Interventions: DRUG: Furmonertinib|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of Bazedoxifene in Postmenopausal Asian Women
Status: COMPLETED
Conditions: Postmenopause|Osteoporosis
Interventions: DRUG: bazedoxifene BZA-20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Efficacy Confirmation Study of NPC-09
Status: COMPLETED
Conditions: GNE Myopathy|Distal Myopathy With Rimmed Vacuoles (DMRV)|Hereditary Inclusion Body Myopathy (hIBM)|Nonaka Disease
Interventions: DRUG: NPC-09|DRUG: NPC-09 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steady-State Pharmacokinetics of Rifaximin 550 mg Tablets in Healthy and Hepatically Impaired Subjects
Status: TERMINATED
Conditions: Severe Hepatic Impairment
Interventions: DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, Tolerability and Immunogenicity of HPV-L2 Vaccine in Healthy Adult Male and Female Subjects
Status: COMPLETED
Conditions: Papillomavirus Infections
Interventions: BIOLOGICAL: AAVLP-HPV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Purpose of This Study is to Evaluate the Safety and Efficacy of Human TH-SC01 Cell Injection in the Treatment of Complex Perianal Fistula
Status: NOT_YET_RECRUITING
Conditions: Complex Perianal Fistulas
Interventions: BIOLOGICAL: Human TH-SC01 Cell Injection|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Study of GSK3196165 Plus Methotrexate (MTX) in Subjects With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: GSK3196165|DRUG: Placebo|DRUG: MTX|DRUG: Folic (or folinic) acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Biomarkers of Bone Mineral Metabolism as Cardiovascular Risk Factors in Chronic Kidney Disease Patients
Status: RECRUITING
Conditions: Chronic Kidney Disease
Interventions: BIOLOGICAL: Plasma osteoprotegerin level|BIOLOGICAL: Plasma fibroblast growth factor 23 level|PROCEDURE: Vascular calcification score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Fordadistrogene Movaparvovec in Early Stage Duchenne Muscular Dystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Muscular Dystrophy, Duchenne
Interventions: GENETIC: PF-06939926
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum
Status: UNKNOWN
Conditions: Thymoma|Myasthenia Gravis|Mediastinal Tumor
Interventions: PROCEDURE: Subxiphoid approach extended thymectomy by VATS|PROCEDURE: Intercostal approach extended thymectomy by VATS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Light Therapy as an Adjunctive Treatment for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Spectramax light therapy device|DEVICE: Control light device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Doxil, Carboplatin, Bevacizumab in Triple Negative Untreated Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Doxil|DRUG: Carboplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intestinimonas for Prevention of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: PreDiabetes
Interventions: DIETARY_SUPPLEMENT: Intestinimonas-capsules|DIETARY_SUPPLEMENT: Placebo-capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MNCs for Bone Marrow Failure After Malignant Diseases Children Chemotherapy
Status: RECRUITING
Conditions: Cord
Interventions: OTHER: Intravenous infusion of cord blood mononuclear cells|DRUG: application of granulocyte stimulating factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nivolumab (BMS-936558) Compared With Dacarbazine in Untreated, Unresectable, or Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: BMS-936558 (Nivolumab)|BIOLOGICAL: Placebo matching BMS-936558 (Nivolumab)|DRUG: Dacarbazine|DRUG: Placebo matching Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in Patients With Unresectable CRLM
Status: UNKNOWN
Conditions: Colorectal Cancer Liver Metastasis
Interventions: DEVICE: Radiofrequency Ablation (RFA)|DRUG: chemotherapy ± target therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Concurrent With Apatinib in Advanced Soft Tissue and Bone Sarcomas of Head and Neck--RASS Study
Status: UNKNOWN
Conditions: Soft Tissue and Bone Tumor|Head and Neck Cancer|Sarcoma
Interventions: DRUG: Apatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine, Palbociclib, and Letrozole Before Surgery in Treating Patients With Estrogen Receptor Positive, HER2 Negative Breast Cancer
Status: COMPLETED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Anatomic Stage IV Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: DRUG: Hydroxychloroquine|DRUG: Letrozole|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroids for Pediatric Apnea Research in Kids
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome
Interventions: DRUG: Nasal Fluticasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Stuttering Remediation Exercises on Cortical Auditory Evoked Potentials
Status: RECRUITING
Conditions: Developmental Stuttering|Evoked Potentials Auditory
Interventions: BEHAVIORAL: Fluency shaping exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Improving Thinking in Everyday Life After Covid-19
Status: COMPLETED
Conditions: Covid-19|Cognitive Impairment
Interventions: BEHAVIORAL: Speed of Processing Training|BEHAVIORAL: Instrumental Activities of Daily Living Shaping|BEHAVIORAL: Transfer Package from CI Therapy|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Miner-Friendly (MF) Service Venues TB/HIV Integration Strategies|BEHAVIORAL: Public Sector (PS) Health Facilities TB/HIV Integration Strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Static Progressive Splinting in the Management of Knee Stiffness Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee
Interventions: OTHER: Multimodal Physical Therapy (MPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients
Status: UNKNOWN
Conditions: Vitamin C Deficiency
Interventions: DRUG: high-dose vitamin C 30gm|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose of a Marketed Drug Being Studied for a New Indication to Treat Surgical Site Infection Following Colorectal Surgery as Compared to a Marketed Drug Approved for This Indication (0826-039)
Status: COMPLETED
Conditions: Colorectal Surgery
Interventions: DRUG: MK0826, ertapenem sodium|DRUG: Comparator: cefotetan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Eccentric Training Effects on Functionality and Neuromechanical Properties After Achilles Tendon Surgical Repair
Status: COMPLETED
Conditions: Achilles Tendon Rupture
Interventions: OTHER: Isokinetic eccentric training|OTHER: Traditional eccentric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Distal Jejunal-release Dextrose Beads Formulation (APHD-012) in Subjects With a Pathological Oral Glucose Tolerance Test (OGTT)
Status: RECRUITING
Conditions: PreDiabetes|Glucose Tolerance Impaired
Interventions: DRUG: APHD-012|DRUG: APH-012P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eicosapentaenoic Free Fatty Acid and Fecal Calprotectin in Inflammatory Bowel Diseases
Status: COMPLETED
Conditions: Ulcerative Colitis|Crohn's Disease
Interventions: DIETARY_SUPPLEMENT: Eicosapentaenoic acid|DIETARY_SUPPLEMENT: Medium chain fatty acid (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hip Fractures Treated With Uncemented Arthroplasties
Status: UNKNOWN
Conditions: Femoral Neck Fractures
Interventions: PROCEDURE: cemented hemiarthroplasty|PROCEDURE: reverse hybrid total hip arthroplasty|PROCEDURE: cemented total hip arthroplasty|PROCEDURE: uncemented hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study Between Simvastatin, Atorvastatin, Rosuvastatin, and GSK2248761 in Healthy Subjects.
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK2248761|DRUG: Simvastatin|DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study on DMMET-01 Versus Metformin on Improvement of Metabolic Control in Naive Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DRUG: DMMET-01|DRUG: Metformin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BI836845 Plus Enzalutamide in Castrate Resistant Prostate Cancer (CRPC)
Status: COMPLETED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: BI 836845|DRUG: Enzalutamide|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Status: COMPLETED
Conditions: Early Menopause|Menopause
Interventions: DIETARY_SUPPLEMENT: Nitrate supplementation|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: -Methylenedioxymethamphetamine (MDMA, Ecstasy) Induced Changes in Drug Metabolism: Gender and Genetic Polymorphisms
Status: COMPLETED
Conditions: Metabolism|Interaction
Interventions: DRUG: MDMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: FFR Driven Complete Revascularization Versus Usual Care in NSTEMI Patients and Multivessel Disease
Status: RECRUITING
Conditions: Coronary Artery Disease|NSTEMI - Non-ST Segment Elevation MI|Fractional Flow Reserve, Myocardial|Myocardial Revascularization|Percutaneous Coronary Intervention
Interventions: PROCEDURE: Ischemia driven revascularization|OTHER: Usual care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsule Versus Sunitinib in Subjects With Advanced Renal Cancer
Status: UNKNOWN
Conditions: Advanced Renal Cancer
Interventions: DRUG: TQB2450|DRUG: Anlotinib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Post-Operative Pain After Use of Calcium Hydroxide and Bio Ceramic Sealer for Root Canal Treatment.
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Endosequence Bio ceramic Sealer|DRUG: Sealapex Calcium hydroxide Based Sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Prospective Assessment of HPV Associated Anogenital Pathology in Female Patients and Female Partners of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma, PAP-OP Study
Status: RECRUITING
Conditions: Oropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cancer Immunotherapy GSK1572932A as Adjuvant Therapy for Patients With Tumor-antigen-positive Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer, Non-Small Cell
Interventions: BIOLOGICAL: Immunotherapeutic GSK1572932A|DRUG: Cisplatin (CDDP)|DRUG: Vinorelbine|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: Radiation|DRUG: Androgen Suppression Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Study Medicine (Nirmatrelvir Plus Ritonavir) in Pregnant Women With COVID-19
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: nirmatrelvir|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PUSH-IT Continuing Enteral Feeds for Tracheostomy
Status: RECRUITING
Conditions: Tracheostomy Complication|Critical Illness|Nutritional Deficiency
Interventions: OTHER: Feeds continued|OTHER: Feeds held
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Home-based tDCS and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms
Status: RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: DEVICE: active tDCS paired with active MBM|DEVICE: sham tDCS paired with active MBM|DEVICE: active tDCS paired with sham MBM|DEVICE: sham tDCS paired with sham MBM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: F38-27: An Evaluation of 2 Different Bowel Cleansing Preparations in Adult Subjects
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: PEG electrolyte lavage solution + bisacodyl - reformulation|DRUG: PEG electrolyte lavage solution + bisacodyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Botox on Reducing Rest Tremor in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Onabotulinumtoxin A Injection|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Shoe Cushioning Position and Properties on Running-related Injury Risk
Status: NOT_YET_RECRUITING
Conditions: Running-related Injury
Interventions: OTHER: Shoe Cushioning Position and Properties
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Oral Treprostinil in Pediatric PAH Patients Aged 7 to 17 Years
Status: COMPLETED
Conditions: PAH
Interventions: DRUG: oral treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cell Implantation in Patients With Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: PROCEDURE: Autologous Adipose Tissue derived MSCs Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAR-T Cells Combined With Dasatinib for Patients With Relapsed and/or Refractory B-cell Hematological Malignancies
Status: RECRUITING
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory|Acute Lymphoblastic Leukemia, in Relapse|Acute Lymphocytic Leukaemia Refractory|Non-Hodgkin's Lymphoma, Relapsed|Non-Hodgkin's Lymphoma Refractory
Interventions: DRUG: CD19/BCMA Targeted CAR T-cells and dasatinib|DRUG: CD19/BCMA Targeted CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients Switched From EC-MPS.
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: DRUG: mycophenolate mofetil [CellCept]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Open-label Study of Alum-adjuvanted Chikungunya Virus-like Particle Vaccine (PXVX0317)
Status: COMPLETED
Conditions: Chikungunya
Interventions: BIOLOGICAL: Chikungunya
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
Status: NOT_YET_RECRUITING
Conditions: Peripheral Artery Disease|Critical Limb Ischemia
Interventions: DRUG: Temsirolimus|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinesio Taping and Manual Therapy Efficacity on Lumbar Pain During Pregnancy
Status: TERMINATED
Conditions: Manual Therapy
Interventions: PROCEDURE: TRIGGER|PROCEDURE: TRIGGER+CURETAPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exercising With a Surgical Mask in Both Athletic and Non-athletic Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: DIAGNOSTIC_TEST: CPET without mask|DIAGNOSTIC_TEST: CPET with mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Single-Agent Glasdegib In Patients With Myelofibrosis Previously Treated With Ruxolitinib
Status: TERMINATED
Conditions: Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Glasdegib (PF-04449913)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examination of Glutamate and mGluR5 in Psychiatric Disorders
Status: RECRUITING
Conditions: Major Depressive Disorder|Post-Traumatic Stress Disorder|Bipolar Disorder
Interventions: BEHAVIORAL: Cognitive Testing|OTHER: MRI|RADIATION: PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Pre-treatment With Magnesium Sulfate on the Duration of Deep Neuromuscular Blockade With Rocuronium
Status: UNKNOWN
Conditions: Magnesium Sulfate|Neuromuscular Blockade|Rocuronium|Deep Neuromuscular Blockade
Interventions: DRUG: Sulfate, Magnesium|OTHER: saline group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Pharmacokinetics and the Absolute Bioavailability of SRT2104 Given as a 250mg Oral Suspension and Intravenous Microdose of 100 µg Carbon-14 Radio-labeled SRT2104 in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: 250 mg SRT2104 Suspension|DRUG: Carbon-14 radio-labeled SRT2104
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Observation of Long-term Cardiac Function Prognosis in Patients With PPCM Who Have Recovered Cardiac Function
Status: NOT_YET_RECRUITING
Conditions: Cardiomyopathy, Dilated
Interventions: DRUG: Patients with cardiac function recovered for more than one year and discontinued were in the discontinuation group.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Microcirculation In Acute Coronary Syndromes
Status: COMPLETED
Conditions: ST Elevation (STEMI) Myocardial Infarction
Interventions: DRUG: Rosuvastatin|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined Use of Ivermectin and Colchicine in COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Ivermectin + colchicine|DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab With Gemcitabine, Oxaliplatin + Rituximab in r/r Elderly Lymphoma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Nivolumab|DRUG: Rituximab|DRUG: Gemcitabine|DEVICE: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib Plus Fulvestrant in Patients With HR+/HER2+ Metastatic Breast Cancer (Pyrotinib+Fulvestrant )
Status: UNKNOWN
Conditions: Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Pyrotinib Plus Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS in Promoting Smoking Cessation and Preventing Relapse in Current Smokers
Status: RECRUITING
Conditions: Cigarette Smoker|Current Every Day Smoker|Current Smoker
Interventions: OTHER: Questionnaire Administration|PROCEDURE: Repetitive Transcranial Magnetic Stimulation|PROCEDURE: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia
Status: COMPLETED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Cefditoren pivoxil 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating MM-310 in Patients With Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumors|Urothelial Carcinoma|Gastric Carcinoma|Squamous Cell Carcinoma of the Head and Neck|Ovarian Cancer|Pancreatic Ductal Adenocarcinoma|Prostate Adenocarcinoma|Non-small Cell Lung Cancer|Small Cell Lung Cancer|Triple Negative Breast Cancer|Endometrial Carcinoma|Soft Tissue Sarcoma
Interventions: DRUG: MM-310
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: AZD7986|DRUG: Verapamil|DRUG: Itraconazole|DRUG: Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mixed Methods Investigation of Chronic Facial Paralysis in Individuals With Synkinesis
Status: COMPLETED
Conditions: Synkinesis
Interventions: OTHER: Neuromuscular Retraining Therapy (4 months)|DRUG: Chemodenervation (4 months)|OTHER: Neuromuscular Retraining + Chemodenervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
Status: RECRUITING
Conditions: Chronic Pain|Chronic Insomnia|Opioid Use
Interventions: BEHAVIORAL: CBT-I|BEHAVIORAL: Treatment as usual|OTHER: Tapered Withdrawal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure|Cytokine Storm|Inflammatory Response|Heart Failure
Interventions: DRUG: Copaxone|DRUG: guideline directed medical therapy (GDMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare How Different Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Handled by the Body of Healthy People and People With Liver Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: Rosuvastatin|DRUG: Digoxin|DRUG: Metformin hydrochlorid|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Antineoplaston Therapy in Treating Patients With Recurrent or Refractory Oligodendroglioma
Status: TERMINATED
Conditions: Oligodendroglioma, Adult
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Collection and Application of Autologous Amniotic Fluid at Cesarean Delivery Closure.
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy Related|Cesarean Wound Disruption|Cesarean Section; Infection
Interventions: DEVICE: Application of Autologous Amniotic Fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Autologous or Syngeneic Stem Cell Transplant Followed by Donor Stem Cell Transplant and Bortezomib in Treating Patients With Newly Diagnosed High-Risk, Relapsed, or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Plasma Cell Myeloma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Bortezomib|DRUG: Cyclosporine|DRUG: Cyclosporine|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Melphalan|DRUG: Mycophenolate Mofetil|PROCEDURE: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|PROCEDURE: Peripheral Blood Stem Cell Transplantation|PROCEDURE: Syngeneic Bone Marrow Transplantation|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cilostazol in Combination With L-Carnitine
Status: COMPLETED
Conditions: Peripheral Vascular Disease|Intermittent Claudication|Peripheral Arterial Disease
Interventions: DIETARY_SUPPLEMENT: Levocarnitine tartrate|DRUG: cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of Recombinant Anti-EGFR Monoclonal Antibody in Patients With Wild-type RAS and BRAF mCRC
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: Recombinant Anti-EGFR Monoclonal Antibody（SCT200）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CB1 Receptors in Human Brown Adipose Tissue
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Cold exposure|OTHER: [18F]FMPEP-d2|OTHER: [18F]FDG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Molecular Neuroimaging to Assess the Link Between Neuroinflammation and Cognitive Impairment in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: 18F-labeled DPA-714 PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nudges for Statin Prescribing in Primary Care
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Clinician Nudge|BEHAVIORAL: Patient Nudge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of the Safety and Pharmacokinetics of Apixaban Versus Vitamin K Antagonist (VKA) or Low Molecular Weight Heparin (LMWH) in Pediatric Subjects With Congenital or Acquired Heart Disease Requiring Anticoagulation
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: Apixaban|DRUG: Vitamin K Antagonist (VKA)|DRUG: Low Molecular Weight Heparin (LMWH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation
Status: RECRUITING
Conditions: Colon Cancer Liver Metastasis|Colon Cancer|Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum|Liver Metastasis Colon Cancer|Colorectal Cancer
Interventions: RADIATION: Y90 TARE|DIAGNOSTIC_TEST: PET/CT|DIAGNOSTIC_TEST: PET/MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Weathering the Storm: Lung, Heart, and Brain Vascular Rehabilitation for COVID-19
Status: UNKNOWN
Conditions: Covid19
Interventions: OTHER: Supervised Exercise Training Protocol|OTHER: Inspiratory Muscle and Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Value Antiproteinuric Effects From Vitamin D Derivatives in Patient With Chronic Kidney Illness and the Lack of Vitamin D
Status: UNKNOWN
Conditions: Kidney Failure, Chronic|Disorder of Vitamin D
Interventions: DRUG: Hidroferol®|DRUG: Paricalcitol: Zemplar®|DRUG: Habitual medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Epidural Etanercept in the Treatment of Sciatica
Status: COMPLETED
Conditions: Sciatica
Interventions: DRUG: epidural injection of etanercept|DRUG: placebo (control procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VR-based Action Observation Treatment for Upper Limb Rehabilitation in Stroke: a Multimodal Study.
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Action Observation and following Action Execution|BEHAVIORAL: Landscape Observation and following Action Execution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abiraterone Acetate and Prednisone With or Without Veliparib in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration-Resistant Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer AJCC v7
Interventions: DRUG: Abiraterone Acetate|OTHER: Laboratory Biomarker Analysis|DRUG: Prednisone|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concomitant Association of Ultrafractionated Brain Irradiation - Temozolomide in Inoperable Primary Glioblastoma Multiforme
Status: COMPLETED
Conditions: Glioblastoma Multiforme
Interventions: RADIATION: Ultrafractionated brain irradiation|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring Responses to Sublingual Antigens
Status: COMPLETED
Conditions: Sexually Transmitted Diseases, Viral
Interventions: BIOLOGICAL: Human Papillomavirus 6,11,16,18 Vaccine Recombinant alum ads|BIOLOGICAL: Human Papillomavirus 6,11,16,18 Vaccine Recombinant alum ads
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE