pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1010 in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza
Interventions: BIOLOGICAL: mRNA-1010|BIOLOGICAL: Egg-based Quadrivalent Influenza Vaccine|BIOLOGICAL: Adjuvanted Quadrivalent Influenza Vaccine|BIOLOGICAL: Inactivated Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Tooth Sensitivity After Scaling and Root Planing Treated With Photobiomodulation
Status: NOT_YET_RECRUITING
Conditions: Photobiomodulation|Dental Hypersensitivity
Interventions: OTHER: Photobiomodulation|OTHER: simulation of Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Follow-up Study for the Patients of Illicit Substance Use Disorder
Status: UNKNOWN
Conditions: Substance Use Disorders|Illicit Drug Use
Interventions: BEHAVIORAL: motivational enhancement interview|BEHAVIORAL: the individual psychotherapy|BEHAVIORAL: the group psychotherapy|BEHAVIORAL: the family therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relevance of the Self-assessment of Skills for Self-administration of Adrenaline by Auto-injectors in Patients at Risk of Severe Anaphylactic Reaction (PacAdré)
Status: UNKNOWN
Conditions: Severe Anaphylactic Reaction, Self-administration, Adrenaline, Self-assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis
Status: UNKNOWN
Conditions: Acute Appendicitis
Interventions: DRUG: Ertapenem, Levofloxacin and Metronidazole|PROCEDURE: Endoscopic retrograde appendicitis therapy (ERAT)|PROCEDURE: Appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BRIDGE Percutaneous Nerve Stimulation for Cesarean Delivery Pain Control
Status: COMPLETED
Conditions: Opioid-use Disorder|Pain, Postoperative
Interventions: DEVICE: NSS-2 Bridge|DEVICE: Inactive NSS-2 Bridge|OTHER: Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Hydromorphone for Post-cesarean Delivery Pain - a Dose Finding Study
Status: TERMINATED
Conditions: Healthy|Pain|Pregnancy
Interventions: DRUG: Hydromorphone 25mcg|DRUG: Hydromorphone 50mcg|DRUG: Hydromorphone 100mcg|DRUG: spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
Status: RECRUITING
Conditions: Adverse Childhood Experiences|Nicotine Dependence, Cigarettes
Interventions: DRUG: Nicotine nasal spray 0.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Use of Tranexamic Acid (TXA) Intravenously, to Reduce Blood Loss in Proximal Femur Surgery
Status: WITHDRAWN
Conditions: Femur Surgery
Interventions: DRUG: Tranexamic Acid (TXA) treatment|DRUG: control grup: without Tranexamic Acid (TXA) treatment.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prospective Multi-center, Single Blinded, Randomized, Controlled Trial of EUS-FNB and EUS-FNA on Solid Occupying Lesion
Status: UNKNOWN
Conditions: Pancreas Neoplasms|Lymphatic Metastasis|Neoplasm Metastases|Unknown Primary Neoplasm Metastasis
Interventions: DEVICE: EUS-FNA (EchoTip Ultra)|DEVICE: EUS-FNB (EchoTip ProCore)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Transcutaneous Electrical Nerve Stimulation in Patients With Total Knee Replacement
Status: UNKNOWN
Conditions: Total Knee Replacement|Transcutaneous Electrical Nerve Stimulation|Total Knee Replacement Surgery
Interventions: DEVICE: TENS (Transcutaneous Electrical Nerve Stimulation) Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HAIC Plus A+T for Patients With High-risk HCC: a Single-arm Phase 2 Trial
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|PROCEDURE: HAIC with FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Inhibition After Pre-hospital Ticagrelor Using Fentanyl Compared to Morphine in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Fentanyl|DRUG: Morphine|DRUG: Ticagrelor|DRUG: Aspirin|DRUG: Unfractioned Heparin|PROCEDURE: Primary PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Videogames on Depression Symptoms and Brain Dynamics
Status: ACTIVE_NOT_RECRUITING
Conditions: Major Depressive Disorder
Interventions: DEVICE: MEL-T01|DEVICE: MEL-S01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tafluprost as an Adjunct to Medical Therapy for Residual Glaucoma After Trabeculectomy
Status: UNKNOWN
Conditions: Glaucoma; Drugs
Interventions: DRUG: tafluprostin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate and Capecitabine in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: capecitabine|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Substance Use Risk Education (SURE) Project
Status: COMPLETED
Conditions: Alcohol Abuse|Alcohol Drinking
Interventions: BEHAVIORAL: Counselor-administered Brief Motivational Intervention (BMI)|BEHAVIORAL: Alcohol 101 Plus (interactive CD-ROM)|BEHAVIORAL: AlcoholEdu (Internet-based tutorial)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Long Arm Vs Short Arm Fiberglass Cast for Treatment of Displaced Distal Radius Fractures
Status: RECRUITING
Conditions: Distal Forearm Fractures
Interventions: PROCEDURE: Closed Reduction|OTHER: Long Arm Fiberglass Cast|OTHER: Short Arm Fiberglass Cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pudendal Nerve Block vs Penile Nerve Block for Analgesia During Pediatric Circumcision
Status: UNKNOWN
Conditions: Male Circumcision|Regional Anesthesia
Interventions: PROCEDURE: Ultrasound-guided pudendal nerve block (PNB) and Ultrasound-guided penile nerve block (DPNB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Lixisenatide in Combination With Oral Anti-Diabetic Treatment in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: lixisenatide AVE0010|DRUG: biguanide|DRUG: TZD|DRUG: alpha-GI|DRUG: glinide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of Smoke-free Legislation on Perinatal Health in the Netherlands
Status: COMPLETED
Conditions: Premature Birth|Perinatal Mortality|Infant, Low Birth Weight|Stillbirth|Infant Mortality|Sudden Infant Death|Infant, Very Low Birth Weight|Infant, Small for Gestational Age
Interventions: OTHER: Smoke-free legislation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial on the Use of Cell Therapy in the Treatment of Patients With Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: ALS (Amyotrophic Lateral Sclerosis)
Interventions: DRUG: MNC (Mononuclear cells)|DRUG: Placebo / Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AZD2624 Multiple Ascending Dose Study in Japan
Status: COMPLETED
Conditions: Healthy|Safety
Interventions: DRUG: AZD2624|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
Status: COMPLETED
Conditions: Antibiotic-associated Diarrhea
Interventions: DRUG: Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet|BIOLOGICAL: BB-12|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cytosponge in Surveillance After Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: cytosponge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery
Status: COMPLETED
Conditions: Multinodular Goitre|Grave's Disease|Thyroid Nodule
Interventions: DEVICE: Ligasure Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Return to Sport and Functional Performance Following Surgical Intervention for Anterior Glenohumeral Instability
Status: RECRUITING
Conditions: Anterior Shoulder Dislocation|Anterior Shoulder Instability
Interventions: PROCEDURE: Bankart Repair and Remplissage|PROCEDURE: Latarjet Coracoid Transfer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Study of CDP870 in Subjects With Chronic Plaque Psoriasis Who Are Candidate for Systemic Therapy and/or Phototherapy/Photochemotherapy
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: Certolizumab Pegol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients With Advanced Biliary Tract Cancer (BTC)
Status: TERMINATED
Conditions: Biliary Tract Cancer
Interventions: DRUG: Nivolumab|DRUG: DKN-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-bacterial Clinical Study on Teeth, Tongue, Cheek, Gum, and Saliva
Status: COMPLETED
Conditions: Plaque, Dental
Interventions: DRUG: Stannous fluoride toothpaste|DRUG: Colgate Dental Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoldering Multiple Myeloma
Interventions: DRUG: Hiltonol|DRUG: Citarinostat|DRUG: Lenalidomide|BIOLOGICAL: PVX-410
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Methylene Blue and Ozone in Early Sepsis
Status: UNKNOWN
Conditions: Sepsis
Interventions: DRUG: methylene blue|DRUG: ozone|OTHER: saline infusion|OTHER: oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic
Status: UNKNOWN
Conditions: Renal Colic
Interventions: DRUG: Ketorolac and nefopam balanced analgesia|DRUG: Balanced analgesia using ketorolac and morphine|DRUG: Pain control with single analgesics (ketorolac)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Case Series on the Clinical Performance of VA Clavicle and Clavicle Hook Plate 2.7 Systems
Status: RECRUITING
Conditions: Clavicle|Acromioclavicular Joint|Fracture
Interventions: DEVICE: DPS VA-LCP® Clavicle Plate 2.7 System; DPS VA-LCP® Clavicle Hook Plate 2.7 System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Examining The Efficacy, Safety And Improved Tolerability Of Travoprost BAK Free Ophthalmic Solution (Travatan-Z) Compared To Prior Prostaglandin Therapy
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Travatan-Z
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.
Status: NOT_YET_RECRUITING
Conditions: Hydroxymethylglutaryl-CoA Reductase Inhibitors|Hypercholesterolemia|Cardiovascular Diseases|Pharmacists|Placebo Effect
Interventions: OTHER: Virtual Statin Management (VSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Smartphones for Selfmonitoring of Skill-use i Dialectical Behavior Therapy
Status: UNKNOWN
Conditions: Borderline Personality Disorder|Emotional Instability|Skill, Coping
Interventions: OTHER: Paper diary sheet|DEVICE: Monsenso DBT-app and IT monitoring program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Clinical Pharmacy Consultations in Patients With Cancer Treated With Oral Anti-cancer Therapies on the Rate of Serious Adverse Events
Status: UNKNOWN
Conditions: Oral Anticancer Therapy.
Interventions: OTHER: Pharmaceutical Consultations|OTHER: No Pharmaceutical Consultations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety, Tolerability, and Pharmacokinetics of AZD7268 After Single Ascending Oral Doses in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: AZD7268|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: Placebo Gel|DRUG: Clonidine Topical Gel (ARC-4558)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Two Different Tablet Formulations Of Bosutinib Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: SKI-606 (Bosutinib)|DRUG: SKI-606 (Bosutinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output
Status: WITHDRAWN
Conditions: Cardiogenic Shock
Interventions: DRUG: Sacubitril-Valsartan|DRUG: Standard Oral Vasodilators
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of New Botanical Component-LFCO- Compared With Existing TTO in Clinical Study
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: LFCO application|OTHER: TTO application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of SPECT-imaging Myocardial Perfusion Heterogeneity
Status: UNKNOWN
Conditions: Coronary Artery Disease|Coronary Atherosclerosis
Interventions: DEVICE: Stress Single Photon Emission Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Duration of Medication Therapy and Outcomes After Holmium Laser Prostate Surgery for Patients With Benign Prostatic Hyperplasia (BPH)
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: PROCEDURE: Holmium Laser Prostate Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Restoration of Pulmonary Compliance After Laparoscopic Gynaecologic Surgery Using a Recruitment Maneuver
Status: COMPLETED
Conditions: Atelectasis|Compliance, Patient
Interventions: DIAGNOSTIC_TEST: Recruitment Maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Comparative Pharmacokinetic Study of ORTHO EVRA (a Transdermal Contraceptive Patch) and CILEST (an Oral Contraceptive) in Healthy Female Volunteers
Status: COMPLETED
Conditions: Contraception|Female Contraception
Interventions: DRUG: EVRA® transdermal contraceptive patch containing 6 mg of norelgestromin and 0.75 mg of ethinyl estradiol (versus CILEST® tablets).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Two Different Types of Forces on Possible Root Resorption in Relation to Dentin Phosphoprotein Levels
Status: COMPLETED
Conditions: Root Resorption
Interventions: OTHER: Continuous force|OTHER: Intermittent force
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nosocomial Infections in ECMO Patients
Status: RECRUITING
Conditions: Acute Respiratory Distress Syndrome|Nosocomial Infection|Extracorporeal Membrane Oxygenation Complication
Interventions: DIAGNOSTIC_TEST: Collection of blood and bronchoalveolar samples to study Pharmacokinetics of ceftazidime/avibactam, meropenem/varbobactam, ceftolozane/tazobactam, or cefiderocol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FAP-targeting PET/CT for Noninvasive Monitoring of Renal Fibrosis
Status: ENROLLING_BY_INVITATION
Conditions: CKD|Renal Fibrosis
Interventions: OTHER: FAP-targeting PET/CT imaging will be performed on the enrolled patients.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatments for Psychogenic Nonepileptic Seizures (NES)
Status: COMPLETED
Conditions: Convulsion, Non-Epileptic|Conversion Disorder|Depression|Stress Disorders, Post-Traumatic
Interventions: DRUG: sertraline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Centanafadine Efficacy and Safety in Adolescents With Attention- Deficit/Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: DRUG: Centanafadine Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal and Urinary Microbiome Trial
Status: COMPLETED
Conditions: Atrophic Vaginitis|Menopause|Recurrent Urinary Tract Infections
Interventions: DRUG: Conjugated equine estrogen topical cream|DRUG: Apricot kernel oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: MRgFUS in the Treatment of Hand and Hip Osteoarthritic Pain
Status: COMPLETED
Conditions: Osteoarthritis|Hip Osteoarthritis|Hand Osteoarthritis
Interventions: DEVICE: MRgFUS treatment|DEVICE: MRgFUS treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated iTBS for Depressed Patients During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: MagPro X100 Stimulator, B70 Fluid-Cooled Coil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Entinostat in Treating Patients With Recurrent Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Azacitidine 30mg/m2|DRUG: Entinostat|DRUG: Azacitidine 40mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms
Status: COMPLETED
Conditions: Schizophrenia and Disorders With Psychotic Features
Interventions: DRUG: Minocycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Progressive Myopia Treatment Evaluation for NaturalVue Multifocal Contact Lens Trial
Status: RECRUITING
Conditions: Myopia
Interventions: DEVICE: Single vision contact lenses|DEVICE: Multifocal contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases
Status: NOT_YET_RECRUITING
Conditions: Radionecrosis of Brain|Brain Metastases
Interventions: DRUG: Bevacizumab|DRUG: Placebo|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide in Patients With Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasability of a Care Pathway Integrating Collaborative Tele-expertise to Prevent Recurring Hospitalisations for Diabetic Patients
Status: RECRUITING
Conditions: Diabetes Mellitus
Interventions: OTHER: Definition of the Individualized Care Pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SHP2 Inhibitor BBP-398 in Combination With Sotorasib in Patients With Advanced Solid Tumors and a KRAS-G12C Mutation
Status: RECRUITING
Conditions: Solid Tumor, Adult|Metastatic Solid Tumor|Metastatic NSCLC|Non Small Cell Lung Cancer
Interventions: DRUG: BBP-398|DRUG: sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontitis and Inflammation in Children With Down Syndrome/Trisomy 21: Study on Biological Samples
Status: NOT_YET_RECRUITING
Conditions: Periodontitis|Trisomy 21
Interventions: PROCEDURE: Biological sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Causal Role of Frontostriatal Circuitry in Goal-directed Behavior
Status: COMPLETED
Conditions: Executive Function
Interventions: DEVICE: Delta-beta TMS|DEVICE: Theta-gamma TMS|DEVICE: Arrhythmic TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Escalation Study of KB001 in Cystic Fibrosis Patients Infected With Pseudomonas Aeruginosa
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: BIOLOGICAL: KB001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Pediatric Size Phlebotomy Tubes in Adult Critically Ill Patients to Reduce Red Blood Cell Transfusions
Status: COMPLETED
Conditions: Anemia
Interventions: DEVICE: Pediatric phlebotomy tubes|DEVICE: Adult phlebotomy tubes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcutaneous Tibial Nerve Stimulation: the ZIDA Device Equivalence
Status: COMPLETED
Conditions: Overactive Bladder|Urge Incontinence|Urinary Incontinence|Urinary Frequency More Than Once at Night
Interventions: DEVICE: Zida
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Text-based Interventions to Promote COVID-19 Vaccinations
Status: COMPLETED
Conditions: Covid19, Vaccines
Interventions: BEHAVIORAL: Patient MyChart Scheduling Link|BEHAVIORAL: Patient Educational Video|BEHAVIORAL: Enhanced Follow through Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Mitiglinide vs Acarbose in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Mitiglinide|DRUG: Acarbose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back
Status: COMPLETED
Conditions: Skin Carcinoma
Interventions: DRUG: tazarotene|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Folic Acid on Efficacy of Sulfadoxine-pyrimethamine in Pregnant Women in Western Kenya
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Sulfadoxine-pyrimethamine/folic acid|DRUG: Sulfadoxine-pyrimethamine/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Web-based Support to Caregivers in Heart Failure
Status: RECRUITING
Conditions: Heart Failure|Family Caregivers
Interventions: BEHAVIORAL: web-based psychoeducational support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optical Coherence Tomography Assessment of Gender diVersity In Primary Angioplasty: The OCTAVIA Trial
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: PROCEDURE: Percutaneous Coronary Intervention|DEVICE: XIENCE PRIME Everolimus Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Study of Tedizolid Phosphate in Pediatric Participants With Gram-Positive Infections (MK-1986-014)
Status: COMPLETED
Conditions: Gram-Positive Infections
Interventions: DRUG: IV Tedizolid Phosphate|DRUG: Oral Suspension Tedizolid Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioengineered Allogeneic Immune Cells (AlloStim) Not Requiring HLA Donor Match for Blood Cancers
Status: TERMINATED
Conditions: Advanced or Refractory Leukemia, Lymphoma, Multiple Myeloma
Interventions: BIOLOGICAL: AlloStim-8|BIOLOGICAL: AlloStim-8|BIOLOGICAL: AlloStim-8|BIOLOGICAL: AlloStim-8
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GP Induction Chemotherapy us TPF Adjuvant Chemotherapy Combined With DDP Concurrent Chemoradiotherapy in the Treatment of Locally Advanced NPC
Status: UNKNOWN
Conditions: Locally Advanced Nasopharyngeal Carcinoma
Interventions: DRUG: GP+CCRT|DRUG: TPF+CCRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intratumoral Cancer Chemotherapy Through a Flexible Bronchoscope as an Adjunct to Brachytherapy
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects
Status: COMPLETED
Conditions: Prediabetic State
Interventions: DIETARY_SUPPLEMENT: BCAA High Protein supplement|DIETARY_SUPPLEMENT: BCAA Low Protein supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of RPL554 With Placebo and Salbutamol in Asthmatic Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: RPL554|DRUG: Salbutamol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Daratumumab Plus Gemcitabine, Dexamethasone, Cisplatin in pt R/R CD38+ PTCL-NOS, AITL and TFH
Status: UNKNOWN
Conditions: Refractory T-Cell Lymphoma|Relapsed T-Cell Lymphoma
Interventions: DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Technique of Pneumatic Posterior Capsulorhexis for Treatment and Prevention of Posterior Capsular Opacification
Status: COMPLETED
Conditions: Posterior Capsule Opacification
Interventions: PROCEDURE: Pneumatic Posterior Capsulorhexis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylprednisolone N Acetylcysteine in Hepatic Resections
Status: TERMINATED
Conditions: Ischemic Reperfusion Injury|Insufficiency; Hepatic, Postoperative|Liver Tumour
Interventions: DRUG: Methylprednisolone|DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of IBI318 Monotherapy for Relapsed/Refractory Extranodal NK/T Cell Lymphoma (Nasal Type) Trial
Status: TERMINATED
Conditions: Extranodal NK/T Cell Lymphoma, Nasal Type
Interventions: DRUG: IBI318(Recombinant human anti-PD1/PD-L1 bispecific antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy Rates in IVF After Ovulation Triggering With Recombinant or Urinary Human Chorionic Gonadotrophin (HCG)
Status: UNKNOWN
Conditions: Embryonic Development|Pregnancy|VEGF
Interventions: DRUG: 10000 IU urinary HCG|DRUG: 250 mcg recombinant HCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 75 or 150 mg Clopidogrel Maintenance Doses Following PCI (ISAR-CHOICE-2)
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH
Status: COMPLETED
Conditions: InFertility
Interventions: DRUG: Pulsatile gonadotropin-releasing hormone (GnRH)|DRUG: Clomiphene Citrate|DRUG: Placebo Pulsatile GnRH|DRUG: Placebo Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
Status: RECRUITING
Conditions: Hip Fractures|Myocardial Injury
Interventions: OTHER: Accelerated medical clearance and surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CyBorD vs. PAD in the Treatment of Newly Diagnosed Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Cyclophosphamide|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PS-341 Alone and PS-341 Plus EPOCH Chemotherapy to Treat Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: B-Cell Lymphoma
Interventions: DRUG: PS-341|DRUG: Etoposide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Cyclophosphamide|DRUG: Prednisone|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is the Expert Nail With Poller Screws Superior to the Distal Tibial Locked Plate in the Management of Short Oblique Distal Tibial Fractures?
Status: COMPLETED
Conditions: Tibia Fracture
Interventions: PROCEDURE: Locking expert intramedullary nail fixation|PROCEDURE: Distal locked plate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
Status: COMPLETED
Conditions: Acne Vulgaris|Allergic Rhinitis|Anxiety|Asthma|Back Pain|Prostatic Hyperplasia|Bursitis|Chronic Obstructive Pulmonary Disease|Cough|Coronary Artery Disease|Depression|Diabetes Mellitus|Diarrhea|Gastroesophageal Reflux|Fibromyalgia|Headache|HIV Infections|Hypothyroidism|Hyperlipidemia|Hypertension|Influenza|Sleep Initiation and Maintenance Disorders|Irritable Bowel Syndrome|Migraine Disorders|Obesity|Obstructive Sleep Apnea|Osteoarthritis|Senile Osteoporosis|Shoulder Pain|Sinusitis|Smoking Cessation|Tobacco Use Cessation|Menopause|Urinary Incontinence|Urinary Tract Infection|Vaginitis|Vertigo
Interventions: OTHER: health information prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Compare Clindamycin Phosphate and Benzoyl Peroxide Topical Gel 1.2%/2.5% to Acanya® Topical Gel in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne
Interventions: DRUG: Clindamycin Phosphate and Benzoyl Peroxide Topical Gel 1.2%/2.5%|DRUG: Acanya Gel|DRUG: Placebo of Clindamycin Phosphate and Benzoyl Peroxide Topical Gel 1.2%/2.5% product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Validation of Pathology-based Artificial Intelligence Diagnostic Model for Lymph Node Metastasis in Prostate Cancer
Status: RECRUITING
Conditions: Prostatic Neoplasms|Lymphatic Metastasis
Interventions: DIAGNOSTIC_TEST: Artificial intelligence (AI)-based diagnostic model (developed)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis
Status: RECRUITING
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Ivacaftor|DRUG: standard of care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Compare the Bioequivalence of Two Fluticasone Propionate 0.05% Topical Creams
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fluticasone Propionate 0.05% Cream-Reference Product|DRUG: Fluticasone Propionate 0.05% Cream-Test product
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Safety and Efficacy of Patients With Familial Hypercholesterolaemia Taking Colesevelam as add-on Therapy to Their Existing Medication
Status: COMPLETED
Conditions: Familial Hypercholesterolemia
Interventions: DRUG: Colesevelam hydrochloride film-coated tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Docetaxel Polymeric Micelles for Injection in Patients With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: Docetaxel Polymeric Micelles for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adipose Stem Cells for Traumatic Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injuries|Paralysis
Interventions: BIOLOGICAL: Autologous, Adipose derived Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stage IV Colorectal CA ALIMTA
Status: COMPLETED
Conditions: Locally Advanced Unresectable or Stage IV Colorectal Cancer
Interventions: DRUG: ALIMTA plus Oxaliplatin versus Oxaliplatin plus 5-Fluorouracil and Leucovorin (FOLFOX 4 Regimen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of JS401
Status: RECRUITING
Conditions: Hyperlipidemia
Interventions: DRUG: JS401|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Bortezomib Combined With ACVBP in Peripheral T-cell Lymphoma
Status: COMPLETED
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: Velcade|DRUG: Doxorubicin|DRUG: Prednisone|DRUG: Cyclophosphamide|DRUG: Vindesine|DRUG: Bleomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Epilepsy Patients BEEP 2b
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Oxcarbazepine (brand name vs generic drugs)|DRUG: Divalproex Sodium (brand name vs generic drugs)|DRUG: Carbamazepine (brand name vs generic drugs)|DRUG: Lamotrigine (brand name vs generic drugs)|DRUG: levetiracetam (brand name vs generic drugs)|DRUG: Topiramate (brand name vs generic drugs)|DRUG: Zonisamide (brand name vs generic drugs)|DRUG: Phenytoin sodium (brand name vs generic drugs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lung Protective One-lung Ventilation With Fix and Variable Tidal Volume
Status: COMPLETED
Conditions: Hypoxemia|Pulmonary Sepsis|ARDS, Human|Pneumonia
Interventions: OTHER: change of ventilatory settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Nefopam for Thermoregulation During Surgery
Status: COMPLETED
Conditions: Hypothermia
Interventions: DRUG: Nefopam Low dose|DRUG: Nefopam High dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose ICG for Biliary Tract and Tumor Imaging
Status: COMPLETED
Conditions: Cholecystitis|Hepatocellular Carcinoma|Liver Metastases
Interventions: DRUG: Indocyanine green|DEVICE: PINPOINT Endoscopic Fluorescence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Impact of Adalimumab on Quality of Life, Health Care Utilization and Costs of Ulcerative Colitis Subjects in the Usual Clinical Practice Setting
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Bran, Psyllium and Nopal on Intestinal Water Content Using Magnetic Resonance Imaging
Status: COMPLETED
Conditions: Constipation|Diet Modification
Interventions: DIETARY_SUPPLEMENT: Bran|DIETARY_SUPPLEMENT: Nopal|DIETARY_SUPPLEMENT: Psyllium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Course and Changes in the Respiratory Microbiota Based on Antibiotic Treatment in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Bronchopulmonary Infection
Interventions: OTHER: sputum samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of FDG and FAPI in Patients With Various Types of Cancer
Status: RECRUITING
Conditions: Tumor, Solid|Positron-Emission Tomography|Metastasis
Interventions: DIAGNOSTIC_TEST: 18F-FDG and 68Ga-DOTA-FAPI -04 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open-Label, Multicenter Study to Evaluate the Safety and Tolerability of Dideoxycytidine (ddC) in Patients With AIDS or Advanced ARC Who Previously Demonstrated Intolerance to Zidovudine (AZT) in Protocol N3300 or N3492
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Mirabegron Increase the Body Heat Generated by the Nervous System
Status: COMPLETED
Conditions: Thermoregulation
Interventions: DRUG: Myrbetriq 25Mg Extended-Release Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cabozantinib in Men With Castration-Resistant Prostate Cancer
Status: TERMINATED
Conditions: Adenocarcinoma of the Prostate|Castration-resistant Prostate Cancer|Recurrent Prostate Cancer|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anatomical Shoulder Domelock System Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Avascular Necrosis|Revision Surgery|Conditions Consequent to Earlier Operations|Arthritis, Rheumatoid|Arthritis, Degenerative|Arthritis;Traumatic
Interventions: DEVICE: AS Domelock System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Behavioral Interventions on Mechanisms of Pain Regulation and Hedonic Regulation
Status: TERMINATED
Conditions: Chronic, Non-neuropathic Back Pain
Interventions: BEHAVIORAL: Mindfulness-Oriented Recovery Enhancement (MORE)|BEHAVIORAL: Support Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Food on the Pharmacokinetics of XZP-3287 in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: XZP-3287|DRUG: XZP-3287|DRUG: XZP-3287|DRUG: XZP-3287|DRUG: XZP-3287|DRUG: XZP-3287
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Autologous Adipose Derived Regenerative Cells for the Treatment of Male Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence , Stress
Interventions: BIOLOGICAL: Periurethral injection of autologous ADRCs and adipose tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intensive Bolus Intravenous Insulin Delivery on Metabolic Integrity in Type 1 and Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus|Metabolic Integrity
Interventions: PROCEDURE: Humulin, Humalog, Novolog
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of Dry Needling and Cold Spray-stretching Treatments
Status: COMPLETED
Conditions: Myofascial Pain Syndromes|Myofascial Trigger Point Pain
Interventions: OTHER: dry needling|OTHER: cold spray and stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT