pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of a Laparoscopic High Intensity Focused Ultrasound Probe for the Ablation of Small Renal Masses
Status: COMPLETED
Conditions: Carcinoma, Renal Cell
Interventions: DEVICE: Sonatherm 600i ablation system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Follow-up of Early Breast Cancer (BC) Patients by Telephone or Mobile Software
Status: COMPLETED
Conditions: Breast Cancer, Early-Onset
Interventions: DEVICE: Mobile software for follow-up of early breast cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative Syndrome
Status: COMPLETED
Conditions: Autoimmune Disease|Lymphoproliferative Disorder
Interventions: DRUG: Fansidar (pyrimethamine and sulfadoxine)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: CD5-deleted Chimeric Antigen Receptor Cells (Senza5 CART5) for T Cell Non-Hodgkin Lymphoma (NHL)
Status: RECRUITING
Conditions: T Cell Non-Hodgkin Lymphoma
Interventions: DRUG: Senza5 CART5
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 16-week Randomized Evaluation of the Impact of Mind.Px Application on Response to Biologic Treatment in Patients Suffering From Plaque Psoriasis Through Clinical Utility and Health Outcomes.
Status: UNKNOWN
Conditions: Plaque Psoriasis
Interventions: DIAGNOSTIC_TEST: Mind.Px Report
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Noninvasive Monitoring of Vital Signs in Neonates
Status: UNKNOWN
Conditions: Admission to the NICU and Need for Physiological Monitoring.
Interventions: DEVICE: The new sensor is not on the market. We have named it Elfi-sensor.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Protecting the Eyes of Gamers With Lubricating Eyedrops
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Syndromes|Computer Vision Syndrome
Interventions: DRUG: TheaLoz Duo Eyedrop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain
Status: WITHDRAWN
Conditions: Compliance|Chronic Pain
Interventions: DRUG: acetazolamide|DRUG: Quinine|DRUG: Riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Refametinib(BAY86-9766) in RAS Mutant Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Refametinib (BAY86-9766)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dupilumab for Prevention of Recurrence of CRSwNP After ESS
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: Dupilumab 300 MG in 2 ML Prefilled Syringe|OTHER: Placebo|DRUG: Mometasone Furoate nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Recovery in Hip Fracture Surgeries
Status: NOT_YET_RECRUITING
Conditions: Hip Fractures
Interventions: PROCEDURE: Spinal Anesthesia|PROCEDURE: General Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Montelukast on Doxorubicin Induced Cardiotoxicity in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Doxorubicin Induced Cardiotoxicity
Interventions: OTHER: Placebo|DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S0329, Gemcitabine and Paclitaxel in Treating Patients With Persistent, Recurrent, or Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: gemcitabine|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estimation of Effective Dose 95 (ED95) of Intrathecal Isobaric 2-chloroprocaine (2-CP) Based on the Height (cm) of a Patient Undergoing Ambulatory Knee Arthroscopy
Status: COMPLETED
Conditions: Knee Arthroscopy
Interventions: DRUG: Isobaric 2-chloroprocaine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-386(2)
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-386|DRUG: D013, D326, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Different Particle Sizes on the Single-dose Pharmacokinetics of Rilpivirine After Intramuscular Injection of a Long-acting Nanosuspension in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rilpivirine|DRUG: Rilpivirine Long-acting Parenteral Formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility of Internet-delivered CBT for Adolescents With Depression
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Therapist-guided internet-delivered cognitive behavior therapy for depression in adolescents|BEHAVIORAL: Self-guided internet-delivered cognitive behavior therapy for depression in adolescents|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Difluprednate 0.05%|DRUG: Prednefrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: Functional Electric Stimulation|OTHER: Rehabilitation programs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Development of Ursodeoxycholic Acid 300 mg at Hospital Das Clinicas of the University of São Paulo School of Medicine
Status: COMPLETED
Conditions: Ursodeoxycholic Acid|Primary Biliary Cirrhosis
Interventions: DRUG: Ursodeoxycholic Acid 300mg tablet|DRUG: Ursodeoxycholic Acid 300mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Strategies for Patients With Chronic Dermatosis With Pruritus / Skin Picking Disorder
Status: COMPLETED
Conditions: Skin-Picking|Acne|Dermatosis
Interventions: BEHAVIORAL: internet-based cognitive-behavioral therapy|BEHAVIORAL: Quality of life improving intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Placement of Proseal Laryngeal Mask Airway With C-Mac Videolaryngoscopy
Status: COMPLETED
Conditions: Laryngeal Masks|Anesthesia, General|Videolaryngoscopy
Interventions: DEVICE: C-MAC videolaryngoscope|DEVICE: Blind
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Prophylactic Ranibizumab for Exudative Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Ranibizumab 0.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tolerance Assessment of Tailored 3d-printed TFO With Silicone Interface for the Treatment of Post-burn Face Scar
Status: NOT_YET_RECRUITING
Conditions: Burn Scar
Interventions: DEVICE: COFIS 3D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study of SHR-1707 in Healthy Young Adult and Elderly Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: SHR-1707|DRUG: Placebo|DRUG: SHR-1707|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: RAT-HEMATO : Return to Work After Malignant Hemopathy
Status: NOT_YET_RECRUITING
Conditions: Leukemia|Lymphoma|Multiple Myeloma
Interventions: OTHER: "Return-to-work after cancer" consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Placebo Optimization of the Presurgical Long-term Video-EEG Monitoring
Status: RECRUITING
Conditions: Symptomatic Epilepsy
Interventions: OTHER: Seizure placebo pill|OTHER: Well-being placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reduction of Pathogen Load From the Blood in Septic Patients With Suspected, Life-threatening Bloodstream Infection
Status: UNKNOWN
Conditions: Bloodstream Infection
Interventions: DEVICE: Seraph 100,The Microbind Affinity Blood Filter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Calcium-fortified Cereal Bars on Dietary Calcium Intake in Women
Status: COMPLETED
Conditions: Calcium Deficiency
Interventions: BEHAVIORAL: Receive Kellogg's Nutri-Grain® cereal bars first|BEHAVIORAL: Receive Kellogg's Nutri-Grain® cereal bars second
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Person-centred Care Transition Support for People With Stroke/TIA
Status: RECRUITING
Conditions: Stroke|Transient Ischemic Attack
Interventions: BEHAVIORAL: Person-centred care transition support|BEHAVIORAL: Regular care transition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Feasibility of 13-C Pyruvate Imaging in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: DRUG: Hyperpolarized Pyruvate (13C) Injection|OTHER: Coil Testing|DRUG: NAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: DRUG: LY3526318|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine if the Midazolam-Meperidine-Dexmedetomidine is Superior to the Midazolam-Meperidine for Sedation During ERCP
Status: COMPLETED
Conditions: Undergoing ERCP for Diagnostic or Therapeutic Purposes
Interventions: DRUG: Dexmedetomidine|OTHER: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Paritaprevir/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C in Canada
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Ombitasvir/paritaprevir/ritonavir|DRUG: Dasabuvir|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct Treatment of Deep Carious Lesions in Children
Status: COMPLETED
Conditions: Dental Caries
Interventions: RADIATION: Antimicrobial photodynamic therapy (aPDT)|OTHER: Without Antimicrobial phothodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SBRT Versus Ablation for Perivascular Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: Stereotactic Body Radiation Therapy|PROCEDURE: radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
Status: RECRUITING
Conditions: Out-Of-Hospital Cardiac Arrest|Postcardiac Arrest Syndrome
Interventions: DRUG: The combined supplement of Ascorbic acid, Thiamine, and Cortisol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Daclatasvir (BMS-790052) Add-on to Standard of Care in Treatment- naïve Patients
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: Daclatasvir|DRUG: Daclatasvir|DRUG: Placebo|DRUG: peg-interferon alfa-2a|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Six Week, Double-Blind Randomized, Efficacy and Safety, Sleep Lab Trial With Esmirtazapine (Org 50081) (P05707)
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: Esmirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM
Status: UNKNOWN
Conditions: Tuberous Sclerosis|Lymphangioleiomyomatosis
Interventions: DRUG: sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors
Status: RECRUITING
Conditions: Metastatic Chondrosarcoma|Locally Advanced Chondrosarcoma|Metastatic Sinonasal Adenocarcinoma|Locally Advanced Sinonasal Adenocarcinoma|Metastatic Large-cell Neuroendocrine Carcinoma|Locally Advanced Large-cell Neuroendocrine Carcinoma|Metastatic Olfactory Neuroblastoma|Locally Advanced Olfactory Neuroblastoma|Metastatic Sinonasal Undifferentiated Carcinoma|Locally Advanced Sinonasal Undifferentiated Carcinoma
Interventions: DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of BSI-045B in Healthy Adult Subjects and Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: BSI-045B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Post-operative Pain After Vital Pulpotomy in Primary Molars Using Allium Sativum Oil Versus MTA
Status: UNKNOWN
Conditions: Deep Caries
Interventions: PROCEDURE: vital pulpotomy primary molars using garlic oil|PROCEDURE: vital pulpotomy using mta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nedaplatin Combined With Gemcitabine in the Treatment of Recurrent and/or Metastatic Nasopharyngeal Carcinoma : a Single Arm and Phase Ⅱ Clinical Trail
Status: TERMINATED
Conditions: Recurrent and Metastatic Nasopharyngeal Carcinoma
Interventions: DRUG: nedaplatin and gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Influenza Viruses Isolated From Immunocompromised Children and Adolescents
Status: COMPLETED
Conditions: Influenza, Human
Interventions: OTHER: Blood sample|OTHER: Nasal swab|OTHER: Oropharyngeal swab|OTHER: Stool sample|OTHER: Symptom checklist
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 5 of 7)
Status: NOT_YET_RECRUITING
Conditions: Exposure to Man-made Visible Light
Interventions: OTHER: Visible light exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Etoricoxib in the Treatment of Osteoarthritis (MK-0663-007)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: MK0663, etoricoxib / Duration of Treatment: Part I (6 weeks), Part II (8 weeks)|DRUG: Placebo;Diclofenac 50mg(tid)/Duration of Treatment: Part I (Placebo) 6 weeks;Part II (Diclofenac) 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Magnesium Sulfate on Reducing Renal Colic in the Emergency Department
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: Magnesium Sulfate|DRUG: D5W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: the Role of Ivabradine in Causing AF in Patients With Chronic Coronary Syndrome
Status: UNKNOWN
Conditions: AF - Atrial Fibrillation
Interventions: DRUG: Ivabradine|DIAGNOSTIC_TEST: transthoracic echo|DEVICE: 24 hours holter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of HNC042 in Healthy Chinese Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: HNC042 for Injection|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block
Status: UNKNOWN
Conditions: Complex Regional Pain Syndrome
Interventions: PROCEDURE: lumbar sympathetic block
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Web-based Support to Manage Arthritis Pain
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Ankylosing Spondylitis|Other Arthritic Conditions (e.g., Psoriatic Arthritis)
Interventions: BEHAVIORAL: painACTION: Arthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Heartburn
Interventions: DRUG: rabeprazole sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Tolerability of STSA-1301 Subcutaneous Injection in Healthy Subjects
Status: COMPLETED
Conditions: Primary Immune Thrombocytopenia
Interventions: DRUG: STSA-1301 subcutaneous injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Crisis Intervention Team (CIT) Mental Health Training for Police Officers
Status: ENROLLING_BY_INVITATION
Conditions: Officers' Skills and Behaviors
Interventions: BEHAVIORAL: Crisis Intervention Team (CIT) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of LY2523355 in Participants With Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: LY2523355|DRUG: ixabepilone|DRUG: pegfilgrastim|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: OTHER: Telehealth|OTHER: In-person PC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Enhanced Support for Behavioral Barriers to Learning: An Evaluation of the SCHOOL STARS Program
Status: COMPLETED
Conditions: Disruptive Behavior Disorder, Childhood Onset|Attention Deficit Hyperactivity Disorder|Oppositional Defiant Disorder in Children|Disruptive Mood Dysregulation Disorder
Interventions: OTHER: enhanced model of primary care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Status: RECRUITING
Conditions: Delirium|Critical Illness|Sedation Complication|Executive Dysfunction|Post Traumatic Stress Disorder
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: LeMaitre LifeSpan® ePTFE Vascular Graft Retrospective Registry
Status: ACTIVE_NOT_RECRUITING
Conditions: Diseased or Occluded Blood Vessels|Arteriovenous Shunting for Blood Access
Interventions: DEVICE: AV Access|DEVICE: PVP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Improve Adolescent Bicycling Safety
Status: RECRUITING
Conditions: Bicycling|Knowledge|Adolescent|Self Efficacy|Education|Attitudes|Practice|Safety|Behavior
Interventions: BEHAVIORAL: Bike Club|BEHAVIORAL: Bike Club Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Personalised Approach Utilising the Frailty Index to Empower Consumers
Status: RECRUITING
Conditions: Gastrointestinal Diseases
Interventions: OTHER: Frailty Assessment|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Pharmacokinetic Study of AR882 in Subjects With Various Degrees of Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: AR882 Single Dose|DRUG: AR882 Multiple Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial in Patients With Relapsed Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Durvalumab, Tremelilumab, MEDI 9447, MEDI 0562
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of F-18 FDG and C-11 Acetate PET in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Fludeoxyglucose PET CT|DRUG: Sodium Acetate C11 PET CT|DRUG: Fludeoxyglucose PET MRI|DRUG: Sodium Acetate C11 PET MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pneumatic Compression and Post-induction Hypotension
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Pneumatic compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Therapy With Fludarabine, Mitoxantrone and Rituximab in Mantle Cell Lymphoma
Status: TERMINATED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Fludarabine, Mitoxantrone and Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Multimodal Physical Exercise and Functional Rehabilitation Program on Fatigue, Pain, Functional Capacity and Quality of Life in Cancer Patients With Tumor Asthenia.
Status: COMPLETED
Conditions: Cancer|Cancer-Related Syndrome|Fatigue
Interventions: OTHER: Multimodal Exercise and Functional Rehabilitation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Resveratrol With or Without Piperine to Enhance Plasma Levels of Resveratrol
Status: COMPLETED
Conditions: Focus of the Study: Normal Volunteers
Interventions: DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Resveratrol 2.5 grams x 1 dose and Piperine 5 mg x 1 dose|DIETARY_SUPPLEMENT: Resveratrol 2.5 grams x 1 dose and Piperine 25 mg x 1 dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Avatrombopag for the Treatment of Thrombocytopenia After Donor Hematopoietic Stem Cell Transplant
Status: WITHDRAWN
Conditions: Platelet Disorder
Interventions: DRUG: Avatrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Study to Evaluate Safety and Tolerability of Valbenazine in Participants With Chorea Associated With Huntington Disease in Canada
Status: ENROLLING_BY_INVITATION
Conditions: Chorea, Huntington
Interventions: DRUG: Valbenazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Oxidized Regenerated Cellulose (ORC) Applied to "Dirty" Surgical Wounds
Status: COMPLETED
Conditions: Infections
Interventions: DEVICE: oxidized regenerated cellulose (Fibrillar SURGICEL)|DEVICE: iodoform gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Laser Acupuncture in Rheumatoid Arthritis Geriatric Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: COMBINATION_PRODUCT: Laser, exercise, and methotrexate|COMBINATION_PRODUCT: Exercise, and methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy on Chronic Knee Joint Osteoarthritis Patients PATIENTS
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Group A (Experimental|DIAGNOSTIC_TEST: Group B (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-MAPTRx in Patients With Mild Alzheimer's Disease
Status: COMPLETED
Conditions: Mild Alzheimer's Disease
Interventions: DRUG: IONIS MAPTRx|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke (ANGEL-ACT): Phase Two
Status: UNKNOWN
Conditions: Intracranial Artery Occlusion With Infarction (Disorder)
Interventions: BEHAVIORAL: ANGEL Intervention Package and Toolbox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Feasibility of a Resistance Exercise and Dietary Protein Intervention in Elderly People in Practice (ProMuscle 65PK)
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Dietary protein products|OTHER: Resistance exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Nurse-led Intervention to Extend the Veteran HIV Treatment Cascade for Cardiovascular Disease Prevention
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Disease|Hypertension|Care Coordination|HIV Treatment Cascade
Interventions: BEHAVIORAL: Intervention group|BEHAVIORAL: Education control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tislelizumab Combined APF Chemotherapy in the Treatment of Locally Advanced Head and Neck Tumors
Status: RECRUITING
Conditions: Head and Neck Tumors
Interventions: DRUG: Tislelizumab, Paclitaxel (albumin-bound type), Cisplatin, 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bring Communities and Technology Together for Healthy Aging
Status: COMPLETED
Conditions: 65 Years Older|Requires IADL Support|Past Year History of Falls and/or Hospitalization
Interventions: OTHER: Elder Tree website
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Cognitive and spOrt Virtual EPIC Training Study for Cardiovascular Diseases
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Physical exercise training|BEHAVIORAL: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sepsis in Geriatric Patients With Suspected Infection.
Status: COMPLETED
Conditions: Sepsis
Interventions: DIAGNOSTIC_TEST: Quick Sequential Organ Failure Assessment (qSOFA)|DIAGNOSTIC_TEST: Modified Early Warning Score (MEWS)|DIAGNOSTIC_TEST: National Early Warning Score (NEWS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases
Status: RECRUITING
Conditions: Cancer|Metastasis|Metastatic Cancer|Brain Metastases|Brain Metastases, Adult
Interventions: DRUG: Azeliragon|RADIATION: Stereotactic radiosurgery|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COntrolled MyeloFibrosis Study With ORal JAK Inhibitor Treatment: The COMFORT-I Trial
Status: COMPLETED
Conditions: MPN (Myeloproliferative Neoplasms)
Interventions: DRUG: Ruxolitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CRx-102 Osteoarthritis Multicenter Evaluation Trial
Status: TERMINATED
Conditions: Knee Osteoarthritis
Interventions: DRUG: CRx-102 (2.7/90)|DRUG: Prednisolone|DRUG: Placebo|DRUG: CRx-102 (2.7/180)|DRUG: CRx-102 (2.7/360)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: (Study: Vertex IIS) Does Ivacaftor Alter Wild Type CFTR-Open Probability In The Sweat Gland Secretory Coil?
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Ivacaftor|DRUG: β-Adrenergic cocktail|DRUG: Pilocarpine Nitrate 5%|DEVICE: Macroduct sweat stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Status: RECRUITING
Conditions: Refractory Epilepsy
Interventions: OTHER: electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration|OTHER: transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of ALXN2050 in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)
Status: RECRUITING
Conditions: Lupus Nephritis|Immunoglobulin A Nephropathy|IgAN|LN
Interventions: DRUG: ALXN2050|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selinexor Combined With R-GemOx as Second-line Treatment in Patients With Diffuse Large B-cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Interventions: DRUG: selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease|Venous Thrombosis|Sickle Cell Trait|Hypercoagulable State|Venous Thromboembolism
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: VG101 Phase I/II to Treat Vulvar and Vaginal Atrophy in Post-Menopausal Women
Status: UNKNOWN
Conditions: Vaginal Atrophy|Vulvar Atrophy
Interventions: DRUG: VG101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety, and Tolerability of Tirabrutinib in Participants With Antihistamine-Resistant Chronic Spontaneous Urticaria
Status: WITHDRAWN
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: Tirabrutinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Angiotensin in Septic Kidney Injury Trial
Status: UNKNOWN
Conditions: Acute Renal Failure|Sepsis|Septic Shock
Interventions: DRUG: Angiotensin II|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INOVATYON STUDY -International, Randomized Study in Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Carboplatin|DRUG: Pegylated Lipoxomal Doxorubicin (PLD)|DRUG: Trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of a Quality of Life Instrument for Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: OTHER: AKRQ questionnaire|OTHER: Skindex-16, DLQI, Skin Health Calculator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: TMC125-TiDP2-C187: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Interaction Between TMC125 and Two Antifungal Agents (Fluconazole and Voriconazole), All at Steady-state in Healthy Subjects.
Status: COMPLETED
Conditions: HIV|AIDS|Fungal Infection
Interventions: DRUG: TMC125
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Second-line Zimberelimab and SIRIOX Chemotherapy for Patient With Previously AG Chemotherapy Treated Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Previously AG Chemotherapy Treated Pancreatic Cancer
Interventions: DRUG: Zimberelimab|DRUG: Oxaliplatin|DRUG: S-1|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: RADIATION: Radiation Therapy|DRUG: Capecitabine 1650 mg/m^2/day|DRUG: Capecitabine 1200 mg/m^2/day|DRUG: Irinotecan|DRUG: Oxaliplatin|PROCEDURE: Surgery|DRUG: Folinic Acid|DRUG: Fluorouracil|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Endostatin Adenovirus Combined With Chemotherapy for Advanced Head and Neck Malignant Tumors
Status: UNKNOWN
Conditions: Head and Neck Neoplasms
Interventions: DRUG: recombinant human endostatin adenovirus|DRUG: Cisplatin injection|DRUG: Paclitaxel injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Hair Regrowth Efficacy and Safety of ALRV5XR in Male Subjects With Hair Loss
Status: COMPLETED
Conditions: Androgenetic Alopecia|Androgenic Alopecia|Telogen Effluvium|Thinning Hair|Hair Loss/Baldness|Hair Thinning
Interventions: DIETARY_SUPPLEMENT: ALRV5XR|OTHER: ALRV5XR Shampoo|OTHER: ALRV5XR Conditioner|OTHER: ALRV5XR Hair Follicle Serum (Nutriment)|DIETARY_SUPPLEMENT: Placebo|OTHER: Placebo Shampoo|OTHER: Placebo Conditioner|OTHER: Placebo Hair Follicle Serum (Nutriment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Insomnia Therapy For Those With Insomnia and Depression
Status: UNKNOWN
Conditions: Insomnia|Major Depressive Disorder
Interventions: DRUG: Escitalopram + CBT-I|BEHAVIORAL: CBT-I plus placebo antidepressant medication|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fibromyalgia and Circadian Blood Pressure
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DEVICE: PBM TREATMENT|DEVICE: PLACEBO PBM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Effects of Vorinostat and HXTC on Persistent HIV-1 Infection in HIV-Infected Subjects Started on Antiretroviral Therapy (ART)
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Vorinostat|BIOLOGICAL: HXTC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles.
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging
Interventions: DRUG: Epidermal Growth Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Determine the Safety and Efficacy of Bio-Ray Knee Guard in Panelists With Varicose Vein and Knee Pain.
Status: NOT_YET_RECRUITING
Conditions: Varicose Veins With Self-declared Knee Pain
Interventions: DEVICE: Bio-Ray Knee Guard
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Based Compassion Training (CBCT) for People Living With HIV (PLHIV)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: BEHAVIORAL: Cognitive-Based Compassion Training (CBCT)|BEHAVIORAL: Health discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Study of Obicetrapib in Combination With Ezetimibe
Status: COMPLETED
Conditions: Dyslipidemias|High Cholesterol|Hypercholesterolemia
Interventions: DRUG: Obicetrapib 5mg|DRUG: Ezetimibe 10mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics in Occupational Shift Workers
Status: COMPLETED
Conditions: Shift-Work Related Sleep Disturbance|Healthy
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: First-in-human Study of S-588210 (S-488210+S-488211)
Status: COMPLETED
Conditions: Lung Cancer|Head and Neck Cancer|Bladder Cancer|Esophageal Cancer|Mesothelioma
Interventions: BIOLOGICAL: S-488210|BIOLOGICAL: S-488211
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BL3000 Compared to Pantogar® in the Treatment of Telogen Effluvium in Women.
Status: UNKNOWN
Conditions: Telogen Effluvium
Interventions: DRUG: BL 3000|DRUG: Reference Pantogar|DRUG: BL3000 Placebo|DRUG: Pantogar - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Ulinastatin for Treatment of Sepsis With Systemic Inflammatory Response Syndrome
Status: UNKNOWN
Conditions: Sepsis
Interventions: DRUG: Ulinastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neo-Adjuvant Immunotherapy With Nivolumab for Non Small Cell Lung Cancer Patients
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Nivolumab 360 mg|DRUG: Paclitaxel 200mg/m2|DRUG: Carboplatin AUC 6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Ibandronate Versus Placebo in Hip Osteonecrosis
Status: TERMINATED
Conditions: Aseptic Hip Necrosis|Hip Necrosis
Interventions: DRUG: ibandronate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of a Single Dose or Two Doses of Shenzhen Quadrivalent Influenza Vaccine
Status: COMPLETED
Conditions: Influenza|Flu
Interventions: BIOLOGICAL: Shz QIV 0.25 mL, 2 doses|BIOLOGICAL: Shz QIV 0.5 mL, 2 doses|BIOLOGICAL: Shz QIV 0.5 mL, single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Propranolol Administration and Prevention of Child PTSD in Child Trauma Victims
Status: COMPLETED
Conditions: Posttraumatic Stress Disorders
Interventions: DRUG: Inderol (propranolol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dermodialysis as Adjuvant Therapy in Renal Failure
Status: UNKNOWN
Conditions: Chronic Renal Failure
Interventions: DEVICE: infra-red sauna|DEVICE: argometer and treadmill|DEVICE: combination of sauna and hot bath
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma|Marginal Zone Lymphoma|Mantle Cell Lymphoma|Small Lymphocytic Lymphoma|Lymphoplasmacytic Lymphoma|Low Grade B-cell Lymphoma, Not Otherwise Specified|Diffuse Large B-cell Lymphoma|Peripheral T-cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Anaplastic Large-cell Lymphoma
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Chemotherapy With Lobaplatin and 5-FU in Recurrent Local or Distant Advanced NPC.
Status: UNKNOWN
Conditions: Recurrent Nasopharyngeal Carcinoma
Interventions: DRUG: Lobaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso.
Status: RECRUITING
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: Rabies vaccine|BIOLOGICAL: RH5.1 10μg adjuvated with 50μg Matrix-M|BIOLOGICAL: RH5.2 5μg adjuvated with 50μg Matrix-M
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION