pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer
Status: UNKNOWN
Conditions: Colonic Diseases|Adenocarcinoma
Interventions: DRUG: leucovorin+5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Abemaciclib|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Methods for Reducing Buccal Infiltration Local Anesthesia Injection Pain
Status: COMPLETED
Conditions: Dental Caries in Children
Interventions: DEVICE: Buzzy device (cold and vibration)|DEVICE: Buzzy device (vibration only)|OTHER: precooling|OTHER: Flavored Benzocaine topical anesthetic gel 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Differences Between Two Type Implants in Post-extraction Alveolus
Status: COMPLETED
Conditions: Dental Implants, Single-Tooth
Interventions: OTHER: A - Bone defect (clinical variables)|OTHER: B- Bacterial plaque index (O'Leary index)(clinical variables)|OTHER: C- Probing depth|OTHER: D- Bleeding on probing|OTHER: E- Gingival phenotype|OTHER: F- Implant insertion torque (Clinical variables)|OTHER: G- Implant stabilization quotient (ISQ) (clinical variables)|OTHER: Morphometric results (Direct measurements - millimeter)|OTHER: Morphometric results (plaster models measurements - millimeter)|OTHER: Imaging Results (X-ray) (millimeter)|OTHER: Imaging Results (CBCT)(millimeter)|OTHER: Photographic results PES/WES index
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: High Flow Nasal Cannulae vs Venturi Mask in Respiratory Failure Due to Pneumonia
Status: RECRUITING
Conditions: Respiratory Insufficiency|Pneumonia
Interventions: DEVICE: High Flow Nasal Cannula Oxygenation|DEVICE: Venturi Mask Oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, PK, and PD of PB2452 With and Without Ticagrelor Pretreatment in Chinese Healthy Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Bentracimab (PB2452) 100 mg or Placebo|DRUG: Bentracimab (PB2452) 300 mg or Placebo|DRUG: Bentracimab (PB2452) 1000 mg or Placebo|DRUG: Bentracimab (PB2452) 1000 mg or Placebo (With Ticagrelor Pre-Treatment)|DRUG: Bentracimab (PB2452) 3000 mg or Placebo (With Ticagrelor Pre-Treatment)|DRUG: Bentracimab (PB2452) 9000 mg or Placebo (With Ticagrelor Pre-Treatment)|DRUG: Bentracimab (PB2452) 18000 mg or Placebo (With Ticagrelor Pre-Treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Levocetirizine to Subjects With Perennial Allergic Rhinitis to House Dust Mites
Status: COMPLETED
Conditions: Rhinitis|Allergic|Perennial
Interventions: DRUG: Levocetirizine dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Multicentre Observational Study to Evaluate Clinical Outcomes of the G7 Acetabular System
Status: ACTIVE_NOT_RECRUITING
Conditions: Noninflammatory Degenerative Joint Disease|Rheumatoid Arthritis
Interventions: DEVICE: Metal on Polyethylene articulation|DRUG: Ceramic on Polyethylene articulation|DEVICE: Ceramic on Ceramic articulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Maytansinoid DM4-Conjugated Humanized Monoclonal Antibody huC242 in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Non-colorectal Cancer|Pancreatic Cancer
Interventions: DRUG: HuC242-DM4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obstetrics and Periodontal Therapy (OPT) Study
Status: COMPLETED
Conditions: Periodontitis|Infant, Premature
Interventions: PROCEDURE: Periodontal scaling and root planing|PROCEDURE: Scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Sacral Neuromodulation in Low Anterior Resection Syndrome
Status: COMPLETED
Conditions: Low Anterior Resection Syndrome|Sacral Neuromodulation - Interstim Therapy|Rectal Cancer
Interventions: DEVICE: Sacral neuromodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conversion Therapy of RAS/BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastases
Status: RECRUITING
Conditions: Colorectal Cancer|Liver Metastases
Interventions: DRUG: mFOLFOXIRI plus Cetuximab|DRUG: mFOLFOXIRI Plus Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study of Safinamide and a BCRP Substrate, Diclofenac, Concomitantly Administered to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Diclofenac sodium|DRUG: Diclofenac sodium and safinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Video Distraction to Decrease Use of Sedation in Pediatric Participants During Radiation Therapy
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|OTHER: Video
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Human ADME
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Intubating Laryngeal Airway in Children
Status: COMPLETED
Conditions: Intubating Laryngeal Airway
Interventions: DEVICE: AirQ Intubating Laryngeal Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Psychological Biofeedback-Relaxation Intervention on Clinical, Physical and Psychological Outcomes in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Attention Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis
Status: COMPLETED
Conditions: Infectious Endocarditis
Interventions: DRUG: Ceftriaxone 4g/ 24h|DRUG: Ceftriaxone 2g/ 12h
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Transumbilical Laparoendoscopic Single Site Cholecystectomy
Status: UNKNOWN
Conditions: Gallstone|Gallbladder Polyps
Interventions: PROCEDURE: CLC|PROCEDURE: TU-LESSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outpatient Treatment Of Deep Venous Thrombosis Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients
Status: TERMINATED
Conditions: Neoplasms|Deep Vein Thrombosis
Interventions: DRUG: Dalteparin (Fragmin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MSX-122 Administered Orally in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
Status: SUSPENDED
Conditions: Solid Tumors
Interventions: DRUG: MSX-122
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of NPT200-11 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: NPT200-11|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Attention Training for Opioid-maintained Cocaine Users
Status: COMPLETED
Conditions: Addiction|Cocaine|Methadone|Opiates
Interventions: BEHAVIORAL: Attentional retraining|BEHAVIORAL: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Identification and Validation of Biomarkers for Breast Cancer Resistance Protein (BCRP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Rosuvastatin|DRUG: Rosuvastatin (Inhibitor arm)|DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase II, Randomized Study of ACZONE™ (Dapsone) Gel, 5% for Papulopustular Rosacea.
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: Vehicle control, 2x/day|DRUG: ACZONE (dapsone) Gel, 5%, 2x/day|DRUG: ACZONE (dapsone) Gel, 5%, 1x/day|DRUG: MetroGel® (metronidazole gel), 1.0% 1x/day|DRUG: ACZONE (dapsone) Gel, 5%, 1x/day (AM) + MetroGel (metronidazole gel), 1.0%, 1x/day (PM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily?
Status: TERMINATED
Conditions: Hypertension in Pregnancy|Hypertension in Postpartum
Interventions: DRUG: Procardia XL 30Mg|DRUG: Procardia XL 60Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy
Status: RECRUITING
Conditions: Bowel Preparation
Interventions: DRUG: CLENPIQ|DRUG: MIRALAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Evidence Based Mental Wellness Programming Online for Adults Across Chronic Physical Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Biliary Cholangitis|Heart Failure|Digestive Diseases|Women Who Have Experienced a Cardiac Event|Cirrhosis, Liver|Post-Transplant|Cancer|Chronic Kidney Diseases|Other Chronic Physical Condition
Interventions: BEHAVIORAL: Online mind-body wellness program|BEHAVIORAL: Online mind-body wellness program + Weekly Check-ins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive and Psychological Disorders After Severe COVID-19 Infection
Status: COMPLETED
Conditions: COVID 19
Interventions: DIAGNOSTIC_TEST: Cognitive assessment|DIAGNOSTIC_TEST: Imaging|DIAGNOSTIC_TEST: Routine care|OTHER: Psychiatric evaluation|OTHER: Psychiatric evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using ROSA for Challenging The TKA Standard of Care
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: PROCEDURE: ROSA PSA Parapatellar Approach|PROCEDURE: ROSA PSA Subvastus Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Local Therapy for Oligometastatic ESCC Patients Treated With PD-1 Inhibitor
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma|Oligometastatic Disease|Radiotherapy
Interventions: COMBINATION_PRODUCT: PD-1 inhibitor+/- chemotherapy combined with local therapy|DRUG: systemic therapy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Precancerous/Nonmalignant Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: monoclonal antibody A27.15|BIOLOGICAL: monoclonal antibody E2.3
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Role of Hyperbaric Oxygen and Neuropsychological Therapy in Cognitive Function Following Traumatic Brain Injury
Status: TERMINATED
Conditions: Brain Injuries, Traumatic|Neuropsychology
Interventions: DEVICE: Hyperbaric Oxygen Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infliximab in High Need Versus Low Need Psoriasis Patients: The IHELP Study (Study P04320)(COMPLETED)
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Unilateral Vestibulopathy and Corticosteroid Treatment
Status: TERMINATED
Conditions: Vestibular Diseases|Vestibular Neuronitis
Interventions: DRUG: Betamethasone|DRUG: Placebo|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Study of Urelumab and Cetuximab in Patients With Advanced/Metastatic Colorectal Cancer or Advanced/Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Head and Neck Cancer
Interventions: BIOLOGICAL: Urelumab|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Biological Effects of a Polyphenol Supplement
Status: COMPLETED
Conditions: Healthy Aging
Interventions: DIETARY_SUPPLEMENT: DailyColors™|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Dose-finding Study of the Bromodomain (Brd) Inhibitor OTX015/ Birabresib (MK-8628) in Hematologic Malignancies (MK-8628-001)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Diffuse Large B-cell Lymphoma|Acute Lymphoblastic Leukemia|Multiple Myeloma
Interventions: DRUG: OTX015/Birabresib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Fitness Impact of Early Physiotherapy Intervention With a Standardized Exercise Therapy Program in Adult Patients Receiving Intensive Induction Chemotherapy for Treatment of Acute Leukemia During Extended Hospitalization.
Status: RECRUITING
Conditions: Acute Leukemia
Interventions: OTHER: KinHémo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of a Outpatient Appendectomy
Status: UNKNOWN
Conditions: Appendicitis Acute|Appendectomy
Interventions: PROCEDURE: Outpatient (OA)|PROCEDURE: Hospitalization appendectomy (HA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Integrated Digitally Enhanced Care for Long-term Conditions- Asthma
Status: WITHDRAWN
Conditions: Asthma
Interventions: DEVICE: myAsthma Application|DEVICE: Lloyds Pharmacy Online Doctor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacokinetics of Oral Doses of RP3128 of Rhizen Pharmaceuticals
Status: TERMINATED
Conditions: Healthy Volunteers|Asthma
Interventions: DRUG: RP3128|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chronic Hepatitis b Patients Switch to tAf After Discontinuation of Nucleoside Analogue
Status: UNKNOWN
Conditions: Chronic Hepatitis b|Hepatitis B Reactivation
Interventions: DRUG: Vemlidy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Oral-esophageal Tube Feeding in Delayed Dysphagia After Radiotherapy for Nasopharyngeal Carcinoma
Status: TERMINATED
Conditions: Nasopharyngeal Carcinoma|Dysphagia
Interventions: DEVICE: Intermittent Oral-esophageal Tube Feeding|DEVICE: nasogastric tube feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Incidence and Risk Factors of Postoperative Delirium in Elderly Patients After Lower Extremity Surgery
Status: COMPLETED
Conditions: Postoperative Delirium
Interventions: BEHAVIORAL: propofol and esmeron(rokuronyum)|BEHAVIORAL: marcaine and fentanyl
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy and Erlotinib for Lung Cancer With Low Abundance Epidermal Growth Factor Receptor Mutation
Status: TERMINATED
Conditions: Non-small-cell Lung Cancer
Interventions: DRUG: Intercalated combination of chemotherapy and erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durvalumab Combined With Chemoradiotherapy for Limited Stage Small Cell Lung Cancer (Camel-01)
Status: RECRUITING
Conditions: SCLC, Limited Stage
Interventions: DRUG: Durvalumab|DRUG: Chemotherapy drug of EP regimen|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia in Total Hip and Knee Arthroplasty
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Hip Osteoarthritis
Interventions: DRUG: Bupivacaine|DRUG: Ropivacaine|DRUG: Mepivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block in Lumbar Release Surgery
Status: COMPLETED
Conditions: Hernia Lumbar|Lumbar Canal Stenosis|Spinal Cord Compression
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stanford Neuromodulation Therapy (SNT) for the Treatment-Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Active iTBS-DLPFC|DEVICE: Sham iTBS-DLPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Inflammation and Lipids
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: EPA|DIETARY_SUPPLEMENT: DHA|DIETARY_SUPPLEMENT: sunflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19
Status: WITHDRAWN
Conditions: Sars-CoV2
Interventions: OTHER: Standard of care (SOC)|DRUG: Hydroxychloroquine|DRUG: Association of diltiazem and niclosamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Chemotherapy Versus Concurrent Chemoradiotherapy in Locally Advanced Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Pre-operative chemotherapy|OTHER: Pre-operative concurrent chemoradiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iCycle II: Recovery of Function Through FES Cycling With VR Biofeedback in People With SCI.
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DEVICE: iCycle Mark 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study Switching HIV-1 Infected Patients With an Undetectable Viral Load on a First Protease Inhibitor-Based Regimen to an Efavirenz-Based Regimen
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Videx EC|DRUG: Epivir|DRUG: Sustiva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shear Wave Sonoelastography in Pediatric Liver Fibrosis
Status: COMPLETED
Conditions: Sonoelastography|Elastography|Elastograms|Liver Fibrosis|Hepatic Fibrosis|Cirrhosis|Pediatrics
Interventions: DEVICE: Shear wave sonoelastography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a TAP Block Given During Laparoscopic Colorectal Surgery to Help Control Pain
Status: COMPLETED
Conditions: Colorectal Disease
Interventions: DRUG: bupivacaine|DRUG: normal saline placebo (for bupivacaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of IK-595 in RAS- or RAF-altered Advanced Tumors
Status: RECRUITING
Conditions: Solid Tumor, Adult|Colorectal Cancer|Pancreatic Cancer|Malignant Melanoma|Ras (Kras or Nras) Gene Mutation|BRAF Gene Mutation|CRAF Gene Mutation|Non-Small Cell Lung Carcinoma|Thyroid Carcinoma|Gliomas, Malignant
Interventions: DRUG: IK-595
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Cetrelimab (JNJ-63723283), a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, Administered in Combination With Apalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration-Resistant Prostatic Neoplasms
Interventions: DRUG: Cetrelimab 480 mg|DRUG: Apalutamide 240 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Preliminary Study of Choline and Betaine Supplementation Among Adults Exposed to Arsenic in Bangladesh
Status: COMPLETED
Conditions: Arsenic Metabolites Measured in Urine
Interventions: OTHER: Placebo|DRUG: Choline bitartrate|DRUG: Betaine|DRUG: Choline bitartrate + Betaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: mupirocin calcium ointment, 2%|DRUG: 3M Skin and Nasal Antiseptic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of the Neuro-Spinal Scaffold for the Treatment of AIS A Cervical Acute SCI
Status: WITHDRAWN
Conditions: Traumatic Cervical Acute Spinal Cord Injury
Interventions: DEVICE: Neuro-Spinal Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Efficacy and Safety of CKD-501 Added to D150 Plus D745 25mg Therapy in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type2 Diabetes
Interventions: DRUG: CKD-501 0.5mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Obese|Overweight
Interventions: RADIATION: Gastric Emptying test|OTHER: Mixed Oral Glucose Tolerance test|DRUG: Conjugated bile acids sodium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study To Evaluate The Efficacy And Safety Of An Investigational Drug In Adolescent And Adult Subjects With Asthma Uncontrolled on Non-steroidal Therapy.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW685698X|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose Chemo/Radiotherapy and Hematopoietic Stem Cell Transplant for Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Cyclophosphamide|DRUG: ATG|DRUG: MESNA|PROCEDURE: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PrOsPective Cohort Study for STereotactic Arhythmia Radioablation (STAR) of Refractory Ventricular Tachycardia
Status: RECRUITING
Conditions: Refractory Ventricular Tachycardia
Interventions: RADIATION: STereotactic Arhythmia Radioablation (STAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation for Post Bleaching Hypersensitivity Using Desensitizing Agent During In-office Bleaching
Status: COMPLETED
Conditions: Tooth Bleaching
Interventions: OTHER: ACP oral care gel|OTHER: glycrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Amniotic Membrane Wrapping and Tenolysis Versus Tenolysis Alone for Treatment of Tendon Adhesions of the Hand/Wrist
Status: UNKNOWN
Conditions: Tendinopathy|Adhesions Nos Postoperative|Scar|Fibrosis
Interventions: BIOLOGICAL: Amnion Tendon Wrapping|PROCEDURE: Surgical Tenolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study on the Impact of Economic Incentives to Improve the Management of Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Diabetes education|BEHAVIORAL: Goal setting|BEHAVIORAL: Companion Support|BEHAVIORAL: Individual Reward|BEHAVIORAL: Shared Reward
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Volume Imaging Using Diagnostic Ultrasound
Status: TERMINATED
Conditions: Bone Injuries|Muscle Injuries|Tendon Injuries
Interventions: PROCEDURE: Ultrasound Scan|DEVICE: Ultrasound Scan using a General Electric Ultrasound Scanner Model Logiq E9 (model name).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Safety, Tolerability, PK and PD of Intracerebroventricular GC1123 in Patients With MPS Ⅱ
Status: RECRUITING
Conditions: Mucopolysaccharidosis II|Hunter Syndrome
Interventions: BIOLOGICAL: GC1123
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hands-Up: Exercise and Education Program After a Wrist Fracture
Status: UNKNOWN
Conditions: Distal Radius Fracture|Osteoporosis
Interventions: OTHER: Hands-Up Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Improving Effect of Autologous Stromal Vascular Fraction (SVF) in Adipose Tissue on Skin Grafting
Status: UNKNOWN
Conditions: Skin; Deformity, Due to Scar
Interventions: BIOLOGICAL: stromal vascular fraction|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|Advanced Solid Tumors|Gastroesophageal Adenocarcinoma|Colorectal Cancer
Interventions: DRUG: ABBV-400|DRUG: Trifluridine/Tipiracil|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing a Patient Navigation Intervention for PrEP Continuum of Care Among Young Latino MSM (PrEParate)
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: Patient Navigation|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bradykinin Receptor Blocker in ACE Inhibitor-associated Angioedema
Status: TERMINATED
Conditions: Angioneurotic Edema
Interventions: DRUG: HOE-140|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Antiviral Therapy With Peg-interferon for Chronic Hepatitis B Complicated With Nonalcoholic Fatty Liver Disease（OCEAN PROJECT）
Status: RECRUITING
Conditions: Nonalcoholic Fatty Liver Disease|Chronic Hepatitis b
Interventions: DRUG: Peg-Interferon α
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAP Block in DIEP or Free MS-TRAM Donor Site: A RCT
Status: COMPLETED
Conditions: Transversus Abdominis Plane (TAP) Block Catheter|DIEP or Free MS-TRAM Breast Reconstruction|Local Pain Management|Abdominal/ Donor Site
Interventions: DRUG: Bupivacaine (study group)|DRUG: Isotonic saline (control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Interval-training in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: CON|BEHAVIORAL: IW-60|BEHAVIORAL: IW-45
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief COVID-19 Intervention for People With Serious Mental Illness and Co-Morbid Medical Conditions
Status: COMPLETED
Conditions: Mental Illness|Chronic Disease
Interventions: BEHAVIORAL: Integrated Illness Management and Recovery|BEHAVIORAL: Chronic Disease Self-Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Safety and Efficacy of an Oxalate Gel or Negative Control on Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: DEVICE: Potassium Oxalate|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Folinic Acid and Vascular Reactivity in HIV
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV) Infection
Interventions: DIETARY_SUPPLEMENT: Folinic Acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Shenkang Decoction on Creatinine and Blood Urea Nitrogen in Chronic Renal Failure Hemodialysis Patients
Status: COMPLETED
Conditions: Chronic Renal Failure|Hemodialysis
Interventions: DRUG: Shenkang decoction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QL1604 Plus Chemotherapy in Subjects With Stage IVB, Recurrent, or Metastatic Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: DRUG: QL1604|DRUG: Paclitaxel injection|DRUG: Cisplatin/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximal Cytoreductive Therapies on Post-treatment Metastases in Pts With mHSPC During Apalutamide Plus ADT Treatment
Status: NOT_YET_RECRUITING
Conditions: Metastatic Prostate Cancer|Castration-Sensitive Prostate Cancer
Interventions: DRUG: apalutamide|DRUG: androgen deprivation therapy|PROCEDURE: cytoreductive radical prostatectomy with/without pelvic lymph node dissection|RADIATION: metastasis-directed therapy with radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiorespiratory Training and Ventilatory Muscle Strength
Status: UNKNOWN
Conditions: Sarcopenia
Interventions: OTHER: Cardiorespiratory training|OTHER: ventilatory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Protein Intake and Early Exercise in Adult Intensive Care Patients
Status: COMPLETED
Conditions: Critically Ill Patients
Interventions: DIETARY_SUPPLEMENT: High protein nutrition|DEVICE: Cycle ergometry exercise|OTHER: Usual care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of a New Formulation of Insulin Glargine With Lantus in Patients With Type 2 Diabetes Mellitus on Basal Plus Mealtime Insulin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: HOE901-U300 (new formulation of insulin glargine)|DRUG: Lantus (insulin glargine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemostatic Effect of Intrauterine Instillation Of Tranexamic Acid In Hysteroscopic Myomectomy
Status: UNKNOWN
Conditions: Surgical Blood Loss|Fibroid
Interventions: DRUG: Topical application Tranexamic acid|DRUG: Placebo (Normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of PillCam With Blood-Sensing Feature: A Feasibility Study
Status: TERMINATED
Conditions: Upper GI Bleeding
Interventions: DEVICE: PillCam® capsule with Given PillCam® Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The DHA (Docosahexaenoic Acid) Oxford Learning and Behaviour (DOLAB) Study
Status: COMPLETED
Conditions: Learning|Behaviour
Interventions: DIETARY_SUPPLEMENT: DHA (docosahexaenoic acid)|DIETARY_SUPPLEMENT: Sunflower oil capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Women's Experience With EVRA (Norelgestromin + Ethinyl Estradiol) Transdermal Contraceptive Patch Compared With Previous Methods of Contraception.
Status: COMPLETED
Conditions: Contraception|Female Contraception
Interventions: DRUG: norelgestromin + ethinyl estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids in Carpal Tunnel Syndrome. Prospective Randomised Controlled Non-inferiority Study
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Systemic bethametasone injection|PROCEDURE: Local bethametasone injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox
Status: ACTIVE_NOT_RECRUITING
Conditions: Monkeypox
Interventions: BIOLOGICAL: JYNNEOS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test
Status: COMPLETED
Conditions: Liver Failure
Interventions: DRUG: 13-C-Methacetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Spinal Cord Stimulation on Gait and Balance in Chronic Low Back Pain Patients
Status: UNKNOWN
Conditions: Chronic Low Back Pain|Pain in Leg, Unspecified
Interventions: DEVICE: Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chronic Subdural Hematoma and Aspirin
Status: COMPLETED
Conditions: Chronic Subdural Hematoma
Interventions: DRUG: Acetylsalicylic acid|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Versus Robotic Myotomy for Treatment of Achalasia
Status: ACTIVE_NOT_RECRUITING
Conditions: Achalasia Cardia
Interventions: PROCEDURE: Robotic Heller Myotomy|PROCEDURE: Peroral Endoscopic Myotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Lymphoblastic Leukemia|Adult Acute Lymphoblastic Leukemia in Complete Remission|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Philadelphia Chromosome Positive|Untreated Adult Acute Lymphoblastic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Doxorubicin|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Methotrexate|DRUG: Ponatinib|DRUG: Ponatinib Hydrochloride|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of AMG 531 to Evaluate the Safety & Efficacy in Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: AMG 531|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Vincristine|DRUG: Doxorubicin|DRUG: Dexamethasone|DRUG: Methotrexate|DRUG: Cytarabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Arteriovenous Fistulae
Status: COMPLETED
Conditions: End-stage Renal Disease
Interventions: DRUG: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sitagliptin Treatment in Patients With Type 2 Diabetes During Ramadan (0431-263)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: Sitagliptin phosphate|DRUG: Comparator: Sulfonylurea|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resilient HIV Implementation Science With SGM Youths Using Evidence
Status: NOT_YET_RECRUITING
Conditions: Hiv
Interventions: BEHAVIORAL: HealthMPowerment (HMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Mobile Technology to Improve Diabetes Care in Adults With Type 1 Diabetes: the REMOTE-T1D Study, a Pilot Study
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: iBGStar meter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Angio-Seal® vs. Exo-Seal® for Closure of Arterial Puncture Sites
Status: COMPLETED
Conditions: Acute Coronary Syndromes|Stable Angina Pectoris
Interventions: DEVICE: percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: p53 Activation in Platinum-Resistant High Grade Serous Ovarian Cancer, a Study of PLD With APR-246
Status: COMPLETED
Conditions: High-grade Serous Ovarian Cancer
Interventions: DRUG: APR-246|DRUG: Pegylated Liposomal Doxorubicin Hydrochloride (PLD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Insulin Detemir Produced by a New Process as Measured by Antibody Formation in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin aspart|DRUG: insulin detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, 4-way Crossover Study to Evaluate the Efficacy of Bilastine in the Vienna Challenge Chamber
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Bilastine|DRUG: Fexofenadine|DRUG: Cetirizine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Consumption of a Fermented Dairy Drink on the Immune Function
Status: COMPLETED
Conditions: Healthy Free-living Elderly
Interventions: OTHER: 1-Fermented Dairy Product (test)|OTHER: 2-Milk-based non-fermented dairy product (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: An Phase III Study of Recombinant Anti-IL-17A Humanized Monoclonal Antibody in Chinese Participants With PsO
Status: NOT_YET_RECRUITING
Conditions: Plaque Psoriasis Patients
Interventions: DRUG: 608 Q2W|DRUG: 608 Q4W
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norepinephrine Weaning Guided by the Hypotension Prediction Index in Vasoplegic Shock After Cardiac Surgery
Status: RECRUITING
Conditions: Vasoplegia|Shock|Norepinephrine|Surgery
Interventions: DRUG: norepinephrine weaning protocol|DRUG: norepinephrine weaning protocol and guided by the HPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pulmonary Tele-rehabilitation and Progressive Muscle Relaxation on Discharged Covid-19 Patients
Status: COMPLETED
Conditions: Covid19
Interventions: OTHER: Pulmonary telerehabilitation|OTHER: progressive muscle relaxation training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Home-based Cardiac Rehabilitation on Outcomes After TAVR
Status: UNKNOWN
Conditions: Aortic Stenosis
Interventions: BEHAVIORAL: Home-based cardiac rehabilitation|BEHAVIORAL: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Candesartan's Effects on Alzheimer's Disease And Related Biomarkers
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Placebo|DRUG: Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Follicular Lymphoma|Relapsed Follicular Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT