pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Extension Study to Assess the Efficacy and Safety of Repeat Treatment With Rituximab (MabThera) in Participants With Active Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Rituximab|DRUG: Methotrexate|DRUG: Methylprednisolone|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Adipose-derived Stem Cells (AdMSCs) for Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: autologous adipose derived stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Lignocaine and Bupivacaine Mix in Adult Safe Male Circumcision
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: DRUG: 3-3-4 mix|DRUG: 4-4-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Irrigation With Combination of 0.9% NaCl and Binahong Extract (Anredera Cordifolia) 2,5% In Allergic Rhinitis
Status: ENROLLING_BY_INVITATION
Conditions: Allergic Rhinitis|Allergic Rhinitis Due to House Dust Mite
Interventions: DRUG: extract Binahong|DRUG: Isotonic saline nasal irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cholangioscopic Assessment of Occluded Biliary Stent and Role of Biliary Radiofrequency Ablation
Status: UNKNOWN
Conditions: Obstructive Jaundice|Cholangitis
Interventions: DEVICE: Single operator cholangioscopy, Endoscopic biliary RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of a Diurnal Indwelling Urethral Catheter to Improve Quality of Life
Status: COMPLETED
Conditions: Spina Bifida|Neurogenic Bladder
Interventions: OTHER: Closed diurnal indwelling catheter (CDIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fractional Inactivated Poliovirus Vaccine Booster and Rotavirus Study
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: IPV at 14 and 22 weeks of age, Rotarix|BIOLOGICAL: IPV at 14 and 22 weeks of age, RotaTeq|BIOLOGICAL: IPV at 14 and fIPV at 22 weeks, Rotarix|BIOLOGICAL: IPV at 14 and fIPV at 22 weeks, RotaTeq|BIOLOGICAL: IPV at 6 and fIPV at 22 weeks, Rotarix|BIOLOGICAL: IPV at 6 and fIPV at 22 weeks, RotaTeq|BIOLOGICAL: fIPV at 6-14-22 weeks of age, Rotarix|BIOLOGICAL: fIPV at 6-14-22 weeks of age, RotaTeq
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Patient Portal - Flu Reminder Recall
Status: COMPLETED
Conditions: Influenza|Respiratory Tract Infections|Vaccines
Interventions: BEHAVIORAL: 1 MyChart R/R|BEHAVIORAL: 2 MyChart R/R|BEHAVIORAL: 3 MyChart R/R
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence Study of Benazepril HCl / Hydrochlorothiazide 20 mg/ 25 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Benazepril HCl/ Hydrochlorothiazide 20 mg/ 25 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Diaphragm-Sparing Nerve Block for Arthroscopic Shoulder Surgery?
Status: COMPLETED
Conditions: Regional Anesthesia Morbidity
Interventions: PROCEDURE: distal nerves blocks group|PROCEDURE: Diaphragmatic function assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endpoint Calibration for a Phase 2 Study of Lisinopril in Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: PROCEDURE: Multiple Sclerosis Functional Composite|PROCEDURE: Mobile Multiple Sclerosis Functional Composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Interscalene vs Anterior and Posterior Suprascapular Nerve Block for Shoulder Arthroscopic Surgeries
Status: COMPLETED
Conditions: Arthroscopic Shoulder Surgery|Interscalene Block|Suprascapular Nerve Block
Interventions: PROCEDURE: ISB|PROCEDURE: aSSB|PROCEDURE: pSSB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Urodynamic Evaluation of Surgical Repair of Pelvic Organ Prolapse Associated With Lower Urinary Tract Symptoms
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: DIAGNOSTIC_TEST: Urodynamic study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multicenter Randomized Open-label Study of Oseltamivir Combined With HD-DEX Versus HD-DEX in the Management of ITP
Status: COMPLETED
Conditions: Thrombocytopenia
Interventions: DRUG: Oseltamivir|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Walking Automaticity in Parkinson's Disease: Levodopa or Donepezil
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dose Escalation Study Of Chinese Herbs In Osteoarthritis Of The Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: HLXL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Observational Cohort Study of SYMBOL CUP DM 2
Status: COMPLETED
Conditions: Revision Total Hip Arthroplasty|Primary Total Hip Arthroplasty
Interventions: DEVICE: THA with SYMBOL CUP DMR HA|DEVICE: THA with SYMBOL CUP DM CEM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ButCoIns GUTS: - Gut Immunological Effects of Resistant Starch and Arabinoxylans in Subjects With Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Western Style Diet|DIETARY_SUPPLEMENT: Healthy Carbohydrate Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy & Safety of KAPVAY™ Extended-Release in Children & Adolescents With Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: clonidine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Demarcation Line Depth in Transepithelial Versus Epithelium-off Accelerated Cross-linking (AXL) in Keratocouns
Status: UNKNOWN
Conditions: Progressive Keratoconus
Interventions: PROCEDURE: corneal cross-linking
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic Seizures
Status: COMPLETED
Conditions: Partial-Onset or Primary Generalized Tonic-Clonic Seizures
Interventions: DRUG: Perampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Progressive Ventricular Dysfunction Prevention in Pacemaker Patients
Status: COMPLETED
Conditions: Cardiac Pacing Indication classI/IIa According AHA/ACC
Interventions: PROCEDURE: dual-chamber pacemaker implantation|PROCEDURE: biventricular dual-chamber pacemaker implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of the Aktivplan Digital Intervention (ACTIVE-CaRe Pilot)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiac Rehabilitation|Secondary Prevention|Cardiovascular Diseases
Interventions: OTHER: aktivplan|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TQB2450 Injection Combined With Stereotactic Body Radiation Therapy (SBRT) in Subjects With Advanced Oligometastatic Non-Small Cell Lung Cancer
Status: UNKNOWN
Conditions: Advanced Oligometastatic Non-small Cell Lung Cancer
Interventions: DRUG: TQB2450|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety, Tolerability and Efficacy of LP-10 in Subjects With Refractory Moderate to Severe Hemorrhagic Cystitis
Status: COMPLETED
Conditions: Hemorrhagic Cystitis
Interventions: DRUG: LP-10
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study in Patients With Schizophrenia by Using Clozaril 100 mg Tablet (Clozapine) and WID-CLZ18
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Clozaril 100 mg (Clozapine)|DRUG: WID-CLZ18
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Folfiri/Cetuximab in FcGammaRIIIa V/V Stage IV Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colorectal Cancer|ADCC
Interventions: DRUG: Folfiri/Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Evaluation of Visual Function After Bilateral Implantation of Two Types of Presbyopia-correcting IOLs
Status: COMPLETED
Conditions: Cataract|Presbyopia
Interventions: DEVICE: SYMFONY IOL|DEVICE: AT LISA tri 839MP IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes in Youth Visiting the ED With Mental Health Issues: a Pilot Text Based Intervention
Status: UNKNOWN
Conditions: Mental Health Disorder|Mental and Behavioral Disorder|Self-inflicted Injury
Interventions: BEHAVIORAL: Text message reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: BEhavioral EConomics for Oral Health iNnovation Trial
Status: COMPLETED
Conditions: Toothbrushing|Dental Plaque|Parent-Child Relations|Oral Hygiene|Dental Caries
Interventions: BEHAVIORAL: Drawing Incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sunitinib Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Adenocarcinoma|Endometrial Endometrioid Adenocarcinoma|Endometrial Serous Adenocarcinoma|Recurrent Uterine Corpus Carcinoma|Stage IVA Uterine Corpus Cancer AJCC v7|Stage IVB Uterine Corpus Cancer AJCC v7|Uterine Carcinosarcoma|Uterine Corpus Carcinosarcoma
Interventions: DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Probiotics on Gastrointestinal Function During Pregnancy
Status: COMPLETED
Conditions: Pregnancy Early|Nausea Gravidarum|Vomiting of Pregnancy
Interventions: DIETARY_SUPPLEMENT: Probiotic 10 (Nature's Bounty)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Therapeutic Strategy in Advanced Bronchioloalveolar Carcinoma
Status: COMPLETED
Conditions: Adenocarcinoma, Bronchiolo-Alveolar
Interventions: DRUG: erlotinib|DRUG: paclitaxel + carboplatine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination
Status: UNKNOWN
Conditions: Malignant Pleural Effusion
Interventions: DRUG: CHEMICAL PLEURODESIS WITH POVIDONE-IODINE-TETRACYCLINE COMBINATION|DRUG: CHEMICAL PLEURODESIS WITH POVIDONE-IODINE ALONE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Cardizem in Pulmonary Arterial Hypertension
Status: WITHDRAWN
Conditions: Idiopathic Pulmonary Arterial Hypertension|Primary Pulmonary Hypertension|Pulmonary Arterial Hypertension|Familial Primary Pulmonary Hypertension
Interventions: DRUG: Diltiazem Hydrochloride|DRUG: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Versus Delayed Urinary Catheter Removal After Minimally Invasive Lumbar Spine Surgery
Status: UNKNOWN
Conditions: Foley Catheterization|Ambulation
Interventions: OTHER: Experimental|OTHER: Active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?
Status: COMPLETED
Conditions: Tooth Extraction|Dental Anesthesia
Interventions: PROCEDURE: Nerve block technique|PROCEDURE: Infiltrative technique|DRUG: 4% articaine 1:100.000 epinephrine|PROCEDURE: Third molar extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions
Status: COMPLETED
Conditions: Coronary Occlusion
Interventions: BIOLOGICAL: Catheter-based intracoronary injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Non-Hodgkin Lymphoma
Interventions: DRUG: ABT-199
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of Lymphoma Using Labeled Technetium-99m 1-Thio-D-Glucose
Status: COMPLETED
Conditions: Hodgkin Lymphoma, Adult|Non-Hodgkin Lymphoma, Adult
Interventions: DIAGNOSTIC_TEST: SPECT with 99mTc-1-thio-D-glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Validation of a Machine Learning Predictive Model to Distinguish Post-capillary Pulmonary Hypertension
Status: RECRUITING
Conditions: Pulmonary Hypertension|Pulmonary Arterial Hypertension|HFpEF - Heart Failure With Preserved Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Optiek predictive model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: COAST Therapy in Advanced Solid Tumors and Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer Recurrent|Solid Tumor, Adult
Interventions: COMBINATION_PRODUCT: Hydroxychloroquine, Metformin, Sirolimus|COMBINATION_PRODUCT: Hydroxychloroquine, Metformin, Sirolimus, Dasatanib|COMBINATION_PRODUCT: Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir|COMBINATION_PRODUCT: Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib|COMBINATION_PRODUCT: Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir|COMBINATION_PRODUCT: Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fascial Scar Mobilization Techniques in Treating Chronic Caesarian Section Scar Pain
Status: UNKNOWN
Conditions: Cesarean Section|Cicatrix|Tissue Adhesions
Interventions: PROCEDURE: deep fascial mobilization|PROCEDURE: superficial fascial mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contralesional Inhibitory rTMS for Recovery of Arm Function After Stroke
Status: UNKNOWN
Conditions: Feasibility Study
Interventions: DEVICE: Active rTMS|DEVICE: Sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A 14 Week Study of Mindfulness Effects on Attentional Control in Older Adults
Status: COMPLETED
Conditions: Cognitive Aging
Interventions: BEHAVIORAL: Mindfulness-inspired treatment|OTHER: Brain health
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Tetracycline in Degradation and Permeability of Collagen Membrane
Status: COMPLETED
Conditions: Ridge Preservation Technique
Interventions: DRUG: The effect of tetracycline in degradation and permeability of collagen membranes.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrobulbar Block Versus Ketamine Infusion for Post-enucleation Analgesia
Status: COMPLETED
Conditions: Enucleated; Eye|Evisceration; Operation Wound|Pain, Postoperative
Interventions: PROCEDURE: Retrobulbar block|PROCEDURE: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study To Assess Adverse Events and Change in Disease Activity Of 24-hour Continuous Subcutaneous Infusion Of ABBV-951 In Adult Participants With Advanced Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson's Disease (PD)
Interventions: DRUG: ABBV-951
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Induction Carboplatin|DRUG: Induction Paclitaxel|PROCEDURE: Resection|DRUG: Consolidation Carboplatin|RADIATION: Radiation Therapy|DRUG: Consolidation Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation of Levofloxacin Triple Therapy for Helicobacter Pylori Eradication
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Levofloxacin|DRUG: Amoxicillin|DRUG: Lansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: What is the Best Sperm Source and Way of Sperm Selection in Cases With Abnormal sORP Levels on the Day of ICSI?
Status: UNKNOWN
Conditions: Oxidative Stress
Interventions: DEVICE: PICSI|PROCEDURE: TESA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Placebo|DRUG: Seralutinib|DEVICE: Generic Dry Powder Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Permanent Pacemaker Implantation or Cardioneuroablation in Sinus Node Dysfunction
Status: RECRUITING
Conditions: Sinus Node Dysfunction
Interventions: PROCEDURE: Permament pacemaker implantation|PROCEDURE: Cardioneuroablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: "Blind" vs. Fluoroscopy-Guided Steroid Injections for Knee Osteoarthritis
Status: WITHDRAWN
Conditions: Osteoarthritis
Interventions: OTHER: Fluoroscopy guided steroid injection|OTHER: Blind Steroid Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake
Status: UNKNOWN
Conditions: Healthy|Obesity
Interventions: DRUG: Denatonium benzoate|DRUG: Quinine hydrochloride|DRUG: Tap water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Label, Single-dose, Dose Escalating Evaluation of the Safety and Tolerability of DBI-001 in Patients With T. Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: J. Lividum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training for Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Other Primary Psychotic Disorders
Interventions: BEHAVIORAL: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia
Status: COMPLETED
Conditions: X-linked Hypophosphatemic Rickets/Osteomalacia
Interventions: DRUG: KRN23
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elemental Diets vs. Semi-solid Diets on Gastric Excretion and Gastroesophageal Regurgitation
Status: WITHDRAWN
Conditions: Gastro-oesophageal Reflux
Interventions: DRUG: Elmental diet|DRUG: Semi-solid diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Fidelity Simulation and Sedation Training of Non-anesthesiologists Residents
Status: COMPLETED
Conditions: Performance of Non-anesthesiologists Residents for the Management of Sedation's Complications
Interventions: OTHER: Simulation|DEVICE: Airway management|BEHAVIORAL: Crisis resource management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Individual and Family Motivational Interviews for Substance Using Truant Teens
Status: COMPLETED
Conditions: Substance Use|Risky Sexual Behavior
Interventions: BEHAVIORAL: Family Check-up/ Individual MI|BEHAVIORAL: Individual and family psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zinc Sulfate in the Treatment of Rosacea: A Randomized, Controlled Trial
Status: TERMINATED
Conditions: Rosacea
Interventions: DRUG: zinc sulfate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Investigate Safety and Efficacy of GSK933776 in Adult Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration
Status: COMPLETED
Conditions: Atrophy, Geographic
Interventions: DRUG: GSK933776|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DIVERT: Diversion of Flow in Intracranial VErtebral and Blood Blister-like Ruptured Aneurysms Trial: A Randomized Trial Comparing Pipeline Flow Diversion and Best-Standard-Treatment
Status: WITHDRAWN
Conditions: Ruptured Aneurysm of Intracranial Artery
Interventions: DEVICE: Flow Diversion|DEVICE: Best Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparison of Indirect Pulp Therapy and Mineral Trioxide Aggregate Pulpotomy in Decayed Primary Molars
Status: COMPLETED
Conditions: Dental Pulp Capping
Interventions: PROCEDURE: Indirect pulp therapy|PROCEDURE: Pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Imatinib in Chronic Myelogenous Patients in Relapse After Stem Cell Transplantation
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WIRE - Novel Treatments in Renal Cell Cancer
Status: RECRUITING
Conditions: Renal Cell Cancer
Interventions: DRUG: Olaparib|DRUG: Cediranib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP)
Status: COMPLETED
Conditions: Polyneuropathy, Amyloid|Neuropathic Pain|Cardiac Failure|Orthostatic Hypotension|Gastrointestinal Disorders
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fostering Efficacy of Anti - PD-1 - Treatment: Nivolumab Plus Radiotherapy in Advanced NSCLC
Status: COMPLETED
Conditions: Carcinoma，Non-Small-Cell Lung|Metastatic Lung Cancer|Nonsmall Cell Lung Cancer|Lung Adenocarcinoma Metastatic|Large Cell Lung Carcinoma Metastatic
Interventions: DRUG: Radiotherapy|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of Induction and Consolidation Chemotherapy With Venetoclax in Patients With Newly Diagnosed AML or MDS-EB-2
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Venetoclax|DRUG: Placebo|COMBINATION_PRODUCT: Standard chemotherapy|OTHER: Autologous stem cell transplantation|OTHER: Allogeneic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Xeloda (Capecitabine) in Combination With XELOX (Oxaliplatin) in Patients With Metastatic Nasopharyngeal Cancer.
Status: COMPLETED
Conditions: Nasopharyngeal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: capecitabine [Xeloda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: RADIATION: Arm 1 stereotactic body radiation therapy|RADIATION: Arm II stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Galcanezumab in Participants With Chronic Cluster Headache
Status: COMPLETED
Conditions: Chronic Cluster Headache
Interventions: DRUG: Galcanezumab 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Diclofenac Topical Sodium Gel 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling and Rehabilitatin Carpal Tunnel Syndrome
Status: RECRUITING
Conditions: Dry Needling|Carpal Tunnel Syndrome|Myofacial Pain
Interventions: OTHER: Dry needling|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fiberoptic Intubation and Transillumination-guided Fiberoptic Intubation：Success Rate and Time in Untrained Medical Personnel
Status: COMPLETED
Conditions: Transillumination-guided Fiberoptic Intubation Intubation
Interventions: DEVICE: Transillumination-guided Fiberoptic Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Nitrocamptothecin in Treating Patients With Metastatic Cancer of the Urinary Tract
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: rubitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in Indonesia
Status: COMPLETED
Conditions: Thalassemia|Pneumococcal Infection
Interventions: DIETARY_SUPPLEMENT: Zinc|DRUG: Sucrose|BIOLOGICAL: PCV Vaccine|BIOLOGICAL: PPV Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Efficiency of Manual Therapy and Exercise in People With Mechanical Neck Pain
Status: COMPLETED
Conditions: Neck Pain|Mobility Limitation
Interventions: OTHER: Manual Therapy|OTHER: Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rhythmic Sensory Stimulation on Fibromyalgia
Status: WITHDRAWN
Conditions: Chronic Pain, Widespread
Interventions: DEVICE: Vibroacoustic Therapy System - VTS 1000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study
Status: RECRUITING
Conditions: Endothelial Dysfunction|Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: Assessment of pulse wave amplitude (PWA)|DIAGNOSTIC_TEST: Salivary Nitric Oxide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Impact of Mechanisms of Action in Unguided Digital Mental Health Interventions
Status: NOT_YET_RECRUITING
Conditions: DPT-STD|DPT-TP
Interventions: BEHAVIORAL: DPT-TP|BEHAVIORAL: DPT-STD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The PIFPAF-PFA Study
Status: RECRUITING
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Pulmonary vein isolation without posterior wall ablation|PROCEDURE: Pulmonary vein isolation with posterior wall ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide in Combination With CHOP in Patients With Untreated PTCL
Status: RECRUITING
Conditions: PTCL, NOS|AITL|ALK- ALCL|Phase III-IV ALK+ ALCL|EATL
Interventions: DRUG: Lenalidomide|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Once-A-Day Prophylaxis for Youth and Young Adults With Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: Kogenate FS, Advate, or Humate-P, Recombinate, Helixate FS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15
Status: RECRUITING
Conditions: Tauopathies
Interventions: DRUG: 11C-HY-2-15 PET|DIAGNOSTIC_TEST: brain MRI|DIAGNOSTIC_TEST: Amyloid PET scan|BEHAVIORAL: Neurological assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Autonomic Nervous Activity During the Systemic Inflammatory Response in Trained and Untrained Healthy Volunteers
Status: COMPLETED
Conditions: Systemic Inflammatory Response Syndrome
Interventions: OTHER: Endotoxin|OTHER: Endotoxin + Nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Learn About How Well Riociguat Works, How Safe it is and How it is Used Under Real World Conditions in Patients in the United States Who Are Receiving Riociguat for High Blood Pressure in the Arteries That Carry Blood From the Heart to the Lungs (Pulmonary Arterial Hypertension, PAH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Therapy of Antibody Hu3F8 With Granulocyte- Macrophage Colony Stimulating Factor (GM-CSF) in Patients With Relapsed/Refractory High-Risk Neuroblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: Hu3F8 With GM-CSF|BIOLOGICAL: Hu3F8 With GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Food Acceptance Through Positive Parenting: the Play and Grow Study
Status: COMPLETED
Conditions: Obesity, Childhood|Overweight, Childhood|Overnutrition|Pediatric Obesity|Eating, Healthy
Interventions: BEHAVIORAL: Associative Conditioning|BEHAVIORAL: Repeated Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission
Status: COMPLETED
Conditions: Plasmodium Falciparum|Asymptomatic Parataemia|Sub Patent Parasitaemia
Interventions: DRUG: Sulfadoxine / Pyrimethamine (SP) plus artesunate (AS)|DRUG: placebo tablet similar to active drug in shape and size
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRebiotic Intervention for Metabolic and MEntal Health (PRIME)
Status: COMPLETED
Conditions: Metabolic Syndrome|Anxiety|Mood|Stress
Interventions: DIETARY_SUPPLEMENT: myota's prebiotic fibre blend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Benzydamine Oromucosal Solution in Oral Mucositis (BOOM)
Status: COMPLETED
Conditions: Radiation-Induced Mucositis|Head and Neck Cancer
Interventions: DRUG: Benzydamine Hydrochloride 0.15% w/v oromucosal solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Two Different Lower Limb Sensory Stimulation Strategies on Balance and Mobility in Older Adults
Status: COMPLETED
Conditions: Elderly|Balance
Interventions: OTHER: compression socks|OTHER: textured insoles|OTHER: smooth socks|OTHER: smooth insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Diagnostic Accuracy of [68Ga]Ga-PSMA-11 PET/CT in Primary Staging of Intermediate and High Risk Prostatic Cancer in Men Newly Diagnosed
Status: RECRUITING
Conditions: Prostate Cancer|Prostatic Neoplasm|Urogenital Neoplasms|Prostatic Disease|Disease Attributes|Neoplasms
Interventions: DIAGNOSTIC_TEST: [68Ga]Ga-PSMA-11 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of the Effect of Exenatide Versus Sitagliptin on 24-hour Average Glucose in Patients With Type 2 Diabetes on Metformin or a Thiazolidinedione
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide|DRUG: sitagliptin|DRUG: placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ozurdex in Reducing PVR After Vitreotomy in PDR
Status: UNKNOWN
Conditions: Diabetic Retinopathy
Interventions: PROCEDURE: slow-release dexamethasone implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Axillary Reverse Mapping (ARM) in Breast Cancer Surgery to Prevent Lymphedema. (ARMtrial)
Status: UNKNOWN
Conditions: Breast Cancer Lymphedema
Interventions: PROCEDURE: Axillary Reverse Mapping (ARM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Chylomicrons Metabolism in Sub-Clinical Atherosclerosis in Patients Whit Heterozigous Familial Hypercholesterolemia (FH) Treated With Statin Plus Ezetimibe
Status: UNKNOWN
Conditions: Heterozigous Familial Hypercholesterolemia
Interventions: DRUG: Statins and Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose:
Clinical trial: A Trial to Find Out How Safe REGN5668 is and How Well it Works When Given With Either Cemiplimab or REGN4018
Status: RECRUITING
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer|Endometrial Cancer
Interventions: DRUG: REGN5668|DRUG: Cemiplimab|DRUG: REGN4018|DRUG: Sarilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Aspheric Toric Intraocular Lens (IOL) Implantation Versus Aspheric Non-Toric Lens Implantation
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Toric T3 - T9|DEVICE: IQ SN60WF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of COVI-VAC as a Booster Dose in Adults Previously Vaccinated Against COVID-19
Status: COMPLETED
Conditions: COVID-19|SARS-CoV-2
Interventions: BIOLOGICAL: COVI-VAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Perioperative Outcomes Between Energy Device During Laparoscopic Gastrectomy
Status: COMPLETED
Conditions: Postoperative Inflammation|Postoperative Fever
Interventions: DEVICE: ULTRACISION Harmonic Scalpel|DEVICE: Ligasure Maryland|DEVICE: Thunderbeat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Docetaxel in Treating Women With Newly Diagnosed Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: pegfilgrastim|DRUG: docetaxel|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Food Effect on the Pharmacokinetics of YM178 in Healthy, Non-elderly Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer|Pharmacokinetics of YM178
Interventions: DRUG: YM178
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Lorcaserin on Cannabis Withdrawal and Self-administration
Status: COMPLETED
Conditions: Cannabis Use
Interventions: DRUG: Lorcaserin|DRUG: Placebo|DRUG: Marijuana
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Lanadelumab to Prevent Hereditary Angioedema (HAE) Attacks in Children
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: DRUG: Lanadelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olanzapine for the Prevention and Treatment of Nausea and Vomiting Induced by Chemotherapy of Lung Cancer
Status: UNKNOWN
Conditions: Chemotherapy-induced Nausea and Vomiting|Lung Cancer
Interventions: DRUG: Olanzapine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evolutionary Systems Therapy for Schizotypy
Status: RECRUITING
Conditions: Schizotypal Personality Disorder
Interventions: BEHAVIORAL: Evolutionary Systems Therapy for Schizotypy|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Intranasal Oxytocin and Cognitive Effects in Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DRUG: Intranasal Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of an Intra-articular Injection of Botulinum Toxin A Associated With Splinting for Base-of-thumb Osteoarthritis
Status: COMPLETED
Conditions: Base-of-thumb Osteoarthritis
Interventions: DRUG: botulinum toxin A|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Velusetrag|DRUG: Velusetrag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Oral Multi-vitamin Carbohydrate Beverage on Intraoperative Nausea and Vomiting
Status: NOT_YET_RECRUITING
Conditions: Nausea and Vomiting, Aspiration, Intraoperative
Interventions: DIETARY_SUPPLEMENT: multi-vitamin carbohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: X-ray Dose Reduction Study for Cardiac Angiography and Intervention
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: RADIATION: Angiographic run with new algorithm and low dose (50% dose)|RADIATION: Angiographic run with predecessor algorithm and dose (100%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraluminal Amoxicillin Powder Monotherapy for Helicobacter Pylori Infection
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Amoxicillin|DRUG: Rabeprazole, Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Duloxetine in Patients Undergoing Lumbar Discectomy
Status: UNKNOWN
Conditions: Acute Pain
Interventions: DRUG: Duloxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Myelodysplasia|Chronic Myeloid Leukemia|Histiocytosis
Interventions: DRUG: Chemotherapy and antibodies|DEVICE: Miltenyi Biotec CliniMACS|PROCEDURE: Allogeneic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placement of Peripheral Venous Catheters Under Echo Guidance in a Post-emergency Medical Service
Status: RECRUITING
Conditions: Catheterization, Peripheral|Echography|Hospital Units
Interventions: DEVICE: ultrasound guidance and therapeutic communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Find a Suitable Dose of ASP8731 and Check for Medical Problems at Each Dose in Healthy Adults
Status: TERMINATED
Conditions: Healthy Participants
Interventions: DRUG: ASP8731|DRUG: ASP8731 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE