pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pediatric Endotracheal Intubation During Resuscitation
Status: UNKNOWN
Conditions: Pediatric|Cardiopulmonary
Interventions: DEVICE: McGRATH® MAC|DEVICE: AirTraq|DEVICE: GlideScope|DEVICE: Miller
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Valsartan/Hydrochlorothiazide Versus Amlodipine and Hydrochlorothiazide in Patients Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan/HCTZ|DRUG: amlodipine|DRUG: HCTZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Allergic Inflammation in Rhinitis Patients Following Nasal Allergen Challenge
Status: COMPLETED
Conditions: Allergic Rhinitis|Asthma
Interventions: DRUG: INCS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CPI-613, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: CPI-613|DRUG: cytarabine|DRUG: mitoxantrone hydrochloride|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Soft Tissue Esthetics Around Immediate Implant Using Dual Zone Therapeutic Concept Versus Buccal Gap Fill to Bone Level
Status: UNKNOWN
Conditions: Immediate Implant and Bone Graft
Interventions: PROCEDURE: dual zone concept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of Target-controlled Intravenous Anaesthesia (TCIVA) in Spinal Cord Stimulation
Status: COMPLETED
Conditions: Failed Back Surgery Syndrome
Interventions: PROCEDURE: Target-controlled intravenous anaesthesia|PROCEDURE: Total anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Pharmacokinetics and Efficacy of STI-2020 (COVI-AMG™) in Outpatients With COVID-19
Status: WITHDRAWN
Conditions: Covid19
Interventions: BIOLOGICAL: COVI-AMG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Azacitidine (Vidaza) vs MGCD0103 vs Combination in Elderly Subjects With Newly Diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Azacitidine|DRUG: MGCD0103|DRUG: MGCD0103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Quadrivalent Influenza Vaccine Given by Intramuscular Route in Subjects Aged 18 to 60 Years
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Quadrivalent influenza vaccine (QIV) (split virion, inactivated) Northern Hemisphere (NH) 2015-2016|BIOLOGICAL: Trivalent influenza vaccine (TIV) (split virion, inactivated) NH 2015-2016 formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effects of Education on Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD
Interventions: BEHAVIORAL: Pranayama|BEHAVIORAL: Education alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Occlusal Reduction Effect on Postendodontic Pain
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: PROCEDURE: Occlusal reduction|PROCEDURE: Sham occlusal reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients
Status: COMPLETED
Conditions: STEMI - ST Elevation Myocardial Infarction|Microvascular Coronary Artery Disease
Interventions: PROCEDURE: pressure-temperature sensor guidewire-based measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PROSPR Project 1: Identifying and Tracking Personalized CRC Screening Regimens for Patients in Clinical Settings
Status: ACTIVE_NOT_RECRUITING
Conditions: ColoRectal Cancer
Interventions: OTHER: Computerized Risk Stratification Tool|OTHER: Algorithmic Risk Stratification Tool|OTHER: Step completion assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Self-Forgiveness on Self-Stigma in Addiction.
Status: COMPLETED
Conditions: Substance Use Disorders|Opiate Dependence|Opiate Withdrawal Syndrome|Opioid-use Disorder|Alcohol Withdrawal|Alcohol Abuse|Alcohol Use Disorder|Cocaine Abuse|Cocaine Use Disorder|Cocaine Withdrawal|Benzodiazepine Abuse|Benzodiazepine Dependence|Substance Abuse|Heroin Overdoses|Heroin Withdrawal|Heroin Abuse
Interventions: BEHAVIORAL: Six Step Model of Self-Forgiveness|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Application of a Biphasic Calcium Sulfate Graft Material in Sinus Floor Elevation
Status: RECRUITING
Conditions: Alveolar Bone Loss|Edentulism Nos
Interventions: PROCEDURE: Sinus floor elevation (SFE)|DIAGNOSTIC_TEST: preoperative cone beam computed tomography (CBCT)|DIAGNOSTIC_TEST: postoperative CBCT|DIAGNOSTIC_TEST: bone core biopsy|PROCEDURE: dental implant placement|PROCEDURE: fixed dental prosthesis (FDP) fabrication|DEVICE: bone grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of GLP-1 on the Inhibition of Glucagon Secretion
Status: COMPLETED
Conditions: Type 2 Diabetes|Type 1 Diabetes
Interventions: DRUG: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))|DRUG: NaCl|DRUG: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))|DRUG: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Web-based Clinical Pedagogy Program to Enhance Nurse Preceptors' Teaching Competency
Status: COMPLETED
Conditions: Web-based Program for Nurse Preceptors
Interventions: OTHER: Web-based clinical pedagogy program (WCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Long COVID Brain Fog: Cognitive Rehabilitation Trial
Status: RECRUITING
Conditions: Long COVID|Brain Fog|Cognitive Impairment|Cognitive Dysfunction|Post-Acute COVID-19 Syndrome
Interventions: BEHAVIORAL: Processing Speed Training|BEHAVIORAL: In-lab Instrumental Activities of Daily Living Training|BEHAVIORAL: In-lab Brain Health Training|BEHAVIORAL: Transfer Package|BEHAVIORAL: Follow Up Phone Calls|BEHAVIORAL: Vocational Rehabilitation|BEHAVIORAL: Peer Mentoring|BEHAVIORAL: Reaction Time Training|PROCEDURE: Trans-auricular Vagus Nerve Stimulation: High Intensity|PROCEDURE: Trans-auricular Vagus Nerve Stimulation: Low Intensity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Trial of CPX-351 + Palbociclib in Patients With Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|AML
Interventions: DRUG: Palcociclib|DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Open-label, Multicenter, Dose Escalation Study of IBI363 (PD1-IL2m) in Subjects With Advanced Solid Malignancies or Lymphomas
Status: UNKNOWN
Conditions: Solid Malignancies or Lymphomas
Interventions: BIOLOGICAL: IBI363
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autoimmune Disease Treatment With Mesenchymal Stem Cells (MSCs) and CAR-T Cells
Status: RECRUITING
Conditions: Autoimmune Diseases
Interventions: BIOLOGICAL: fetal MSCs combined with 4SCAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia
Status: COMPLETED
Conditions: Gram-negative Bacteremia
Interventions: DEVICE: Accelerate PhenoTest™ BC Kit|DEVICE: Standard Culture and AST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Etrumadenant (AB928)|RADIATION: Radiation therapy|DRUG: FOLFOX regimen|DRUG: Zimberelimab (AB122)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a DeskCycle to Reduce Sedentary Behavior During the Workday
Status: COMPLETED
Conditions: Chronic Disease|Reduction, Weight
Interventions: BEHAVIORAL: Cycling/Using a DeskCycle|BEHAVIORAL: Regular activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Bioequivalence and Adhesion of a Transdermal Contraceptive Patch Manufactured With Newly Sourced Adhesive Components and Currently Marketed EVRA in Healthy Adult Women
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: EVRA patch (NGMN+EE) (Treatment A) (Reference)|DRUG: HMW PIB patch (NGMN+EE) (Treatment B) (Test)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety and Effectiveness of EyePeace on Signs and Symptoms of Dry Eye Disease
Status: NOT_YET_RECRUITING
Conditions: Evaporative Dry Eye
Interventions: DEVICE: EyePeace|DEVICE: Heated Eye Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy in Patients With Metastatic Esophageal Cancer Responding to PD-1 Inhibitor Plus Chemotherapy
Status: RECRUITING
Conditions: Esophageal Neoplasm Metastatic|Esophageal Cancer Stage IVb
Interventions: DRUG: TP (Paclitaxel with cisplatin or carboplatin) or PF (Fluoropyrimidine with cisplatin or carboplatin) regimen depended on investigator's choice.|BIOLOGICAL: PD-1 inhibitor|RADIATION: Consolidation Radiation|RADIATION: Salvage Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy of Prolotherapy Treatment in Patients With Plantar Fasciitis: a Randomized Double-blind Study
Status: COMPLETED
Conditions: Plantar Fascitis
Interventions: OTHER: 5 cc 30% dextrose + 4 cc salin + 1cc 2% lidocaine.|OTHER: 9 cc salin + 1cc 2% lidocaine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Postoperative Delirium With Continuous Theta Burst Stimulation
Status: UNKNOWN
Conditions: Postoperative Delirium|Continuous Theta Burst Stimulation
Interventions: DEVICE: Continuous theta burst stimulation (cTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion
Status: COMPLETED
Conditions: Type 2 Diabetes|Prediabetes
Interventions: DRUG: alpha lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fruquintinib CYP3A Inhibitor and Inducer Study
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Fruquintinib|DRUG: Itraconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Trial of huA33 Plus Chemotherapy in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: huA33
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cisplatin Combined With S-1 or Paclitaxel as First-line Treatment for Metastatic Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Cisplatin Combined With S-1|DRUG: Cisplatin Combined With Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Bronchodilator Effect of Inhaled Albuterol Sulfate and Ipratropium Bromide in Patients With Stable COPD
Status: COMPLETED
Conditions: COPD
Interventions: COMBINATION_PRODUCT: Albuterol Sulfate and Ipratropium Bromide|COMBINATION_PRODUCT: Albuterol Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress
Status: COMPLETED
Conditions: Asthma|Pneumonia|Respiratory Distress Syndrome
Interventions: DEVICE: Photo Electrochemical Oxidation (PECO) for Air Purification
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Kingasa Pilot Study
Status: COMPLETED
Conditions: HIV|Linkage to Care|PMTCT|PrEP|ART Adherence
Interventions: DIAGNOSTIC_TEST: POC viral load testing|OTHER: Wellness visit services for male partners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Leg Length Discrepancy and Adolescent Idiopathic Scoliosis: Clinical and Radiological Characteristics
Status: COMPLETED
Conditions: Leg Length Inequality|Scoliosis|Pelvic Obliquity
Interventions: DIAGNOSTIC_TEST: Leg Length Discrepancy Scoliometer Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of GDC-9545 Alone or in Combination With Palbociclib and/or Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: GDC-9545|DRUG: Palbociclib|DRUG: LHRH Agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Package of Interventions to Reduce the Burden of Malaria in the Urban Daaras of Touba, Senegal
Status: ACTIVE_NOT_RECRUITING
Conditions: Malaria
Interventions: COMBINATION_PRODUCT: Intervention package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety and Tolerability of STSA-1005 Following Intravenous Infusion in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: STSA-1005 injection|DRUG: Placebo|DRUG: STSA-1005 injection|DRUG: Placebo|DRUG: STSA-1005 injection|DRUG: Placebo|DRUG: STSA-1005 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Angiogenesis-related Pathways in the Development of Port Wine Stains
Status: COMPLETED
Conditions: Port Wine Stain
Interventions: RADIATION: Pulsed dye laser (PDL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase IIIb, Multicenter, International Study to Evaluate the Efficacy, Safety and Tolerability of EK-12 in Patients With RRMS
Status: TERMINATED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: EK-12|DRUG: INF beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Compare Cold Snare Underwater Polypectomy to Cold Snare Conventional Polypectomy for Colon Polyps [COLDWATER Study]
Status: COMPLETED
Conditions: Colon Polyps|Polypectomy
Interventions: PROCEDURE: Underwater Cold Snare Polypectomy|PROCEDURE: Conventional Cold Snare Polypectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dengzhanxixin Injection for Acute Ischemic Stroke Receiving Reperfusion Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Dengzhanxixin Injection|DRUG: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Electrocoagulation Versus Sclerosing Foam for Patients With Incompetent Perforating Veins
Status: RECRUITING
Conditions: Incompetent Perforating Veins
Interventions: PROCEDURE: treatment: puncture of coagulation|PROCEDURE: treatment: sclerosing agent injected
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Approaches for Open Reduction and Internal Fixation of Mandibular Condylar Fracture
Status: NOT_YET_RECRUITING
Conditions: Mandibular Fractures
Interventions: PROCEDURE: ORIF through transparotid approach|PROCEDURE: ORIF through retroparotid approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]AlF-NOTA-FAPI-04 PET/CT in Inflammation and Fibrosis in Renal Diseases
Status: RECRUITING
Conditions: 18F-FAPI PET/CT Examination|Renal Puncture Biopsy
Interventions: DEVICE: [18F]AlF-NOTA-FAPI-04 PET/CT examination|PROCEDURE: Renal puncture biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Guided Trigeminal Nerve Block in Maxillofacial Surgeries
Status: ACTIVE_NOT_RECRUITING
Conditions: Maxillofacial Injuries
Interventions: PROCEDURE: trigeminal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation Combined With Melatonin in the Treatment of Stage IA NSCLC
Status: UNKNOWN
Conditions: NSCLC and Theropy
Interventions: PROCEDURE: RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess the Efficacy and Safety of YYC405 in Type 2 Diabetes Patients
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: YYC405-T|DRUG: Metformin≥1000mg|DRUG: Dapagliflozin 10mg|DRUG: YYC405-T placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 3 Months to 5 Years Old
Status: COMPLETED
Conditions: Dysentery|Dysentery, Bacillary
Interventions: BIOLOGICAL: S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine|BIOLOGICAL: S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine|BIOLOGICAL: S.Flexneriza-S.Sonnei Bivalent Conjugate Vaccine|BIOLOGICAL: Haemophilus b Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Clinical Trial of RC19D2 Cell Injection in the Treatment of Diffuse Large B-cell Lymphoma
Status: RECRUITING
Conditions: Recurrent Diffuse Large B-Cell Lymphoma|Refractory Diffuse Large B-cell Lymphoma
Interventions: BIOLOGICAL: RC19D2 cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CORIMUNO19-ECU: Trial Evaluating Efficacy and Safety of Eculizumab (Soliris) in Patients With COVID-19 Infection, Nested in the CORIMUNO-19 Cohort
Status: UNKNOWN
Conditions: SARS-CoV-2|COVID19
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Long Term Safety of Lacosamide (LCM) to Carbamazepine Controlled-release (CBZ-CR); Initial Monotherapy in Epilepsy Subjects 16 Years and Older
Status: COMPLETED
Conditions: Epilepsy|Monotherapy
Interventions: DRUG: Lacosamide|DRUG: Carbamazepine-Controlled Release (CBZ-CR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Robot-assisted Technique vs Conventional Technique in Preventing Early Micromobilisation After UKA
Status: RECRUITING
Conditions: Loosening, Prosthesis
Interventions: PROCEDURE: Robot-assisted UKA|PROCEDURE: Standard technique UKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Study to Evaluate the Safety and Efficacy TPI ASM8 in Subjects With Asthma
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: BIOLOGICAL: TPI ASM8|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patients
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Ipilimumab|DRUG: GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supraspinal Processing of Sensory Aspects of Pain
Status: RECRUITING
Conditions: Migraine in Children|Complex Regional Pain Syndromes|Musculoskeletal Pain|Functional Abdominal Pain Syndrome|Fibromyalgia
Interventions: OTHER: Multisensory Task|OTHER: Graphesthesia|OTHER: Divided attention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexamethasone Dyspnea Study
Status: COMPLETED
Conditions: Advanced Cancers|Hematologic Disorder|Solid Tumors
Interventions: DRUG: Dexamethasone|DRUG: Placebo|BEHAVIORAL: Questionnaires|DEVICE: Spirometer|OTHER: Phone Calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cemented and Cementless Prostheses for Unstable Intertrochanteric Fractures in the Elderly
Status: COMPLETED
Conditions: Intertrochanteric Fractures
Interventions: DEVICE: cemented SPII prosthesis|DEVICE: cementless Wagner prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minoxidil 2% Solution and Botanical Hair Regimen in Women With Thinning Hair and Female Pattern Hair Loss/Androgenic Alopecia
Status: COMPLETED
Conditions: Female Pattern Hair Loss, Androgenic Alopecia
Interventions: DRUG: Treatment: Minoxidil 2% / Botanical Hair Solution for Women
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sirolimus & Mycophenolate Mofetil as GvHD Prophylaxis in Myeloablative, Matched Related Donor HCT
Status: TERMINATED
Conditions: Hematologic Diseases|Acute-graft-versus-host Disease|Leukemia|Non-Hodgkin Lymphoma (NHL)|Hodgkin Lymphoma
Interventions: DRUG: Sirolimus|DRUG: Mycophenolate mofetil (MMF)|DRUG: Carmustine|DRUG: Etoposide|DRUG: Cyclophosphamide (Cyclo, CY)|DRUG: FTBI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)
Status: TERMINATED
Conditions: Metastases, Neoplasm|Carcinoma, Non-Small-Cell Lung|Brain Neoplasms
Interventions: DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy of Para-discal Infiltration in Patients With Lateralized MODIC 1 Inflammatory Disc Disease
Status: RECRUITING
Conditions: Degenerative Disc Disease|Inflammation|Low Back Pain
Interventions: PROCEDURE: Para-discal injection of corticoid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomechanical Relationship Between Trunk Flexion and Mouth Opening: Pilot Study
Status: COMPLETED
Conditions: Hamstring Injury|Temporomandibular Joint Disorders|Stretch
Interventions: OTHER: Self-stretching of the masticatory musculature|OTHER: Control group intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Postoperative Delirium With CAM ICU Score in Patients Treated With Serotoninergic Reuptake (SSRI) Inhibitors and Undergoing Intervention of Heart Surgery on Pump
Status: COMPLETED
Conditions: Delirium
Interventions: OTHER: evaluation of delirium with CAM-ICU Score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robotic Brace Incorporating Electromyography (EMG) for Moderate Affected Arm Impairment After Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Myomo e100 Robot and repetitive task specific training|BEHAVIORAL: Repetitive task specific training (RTP) targeting the affected arm|DEVICE: Myomo e100 neurorobotic brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women
Status: NOT_YET_RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Behavioral weight loss intervention (Online; Rx Weight Loss)|BEHAVIORAL: Minority stress intervention|BEHAVIORAL: Social support intervention|BEHAVIORAL: Negative body image intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ascending Single-Dose and Multiple-Dose Study to Evaluate HSK31679 in Healthy Subjects and Subjects With Elevated LDL-C
Status: COMPLETED
Conditions: Healthy|Elevated LDL-C
Interventions: DRUG: HSK31679|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of TG103 Injection in Overweight or Obesity
Status: UNKNOWN
Conditions: Overweight or Obesity
Interventions: DRUG: TG103 15 mg|DRUG: TG103 22.5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: In Situ Caries Efficacy of Fluoride Toothpastes
Status: COMPLETED
Conditions: Caries
Interventions: DRUG: NaF|DRUG: Placebo|DRUG: NaMFP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robot-Assisted Laparoscopic Radio Frequency Ablation Assisted Enucleation of Renal Cell Carcinoma With T1a Stage
Status: UNKNOWN
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: zero ischemia robot-assisted laparoscopic RFA assisted TE|PROCEDURE: zero ischemia robot-assisted laparoscopic partial nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure
Status: RECRUITING
Conditions: Aging|Heart Failure With Preserved Ejection Fraction|Heart Failure With Reduced Ejection Fraction|Frailty|Physical Function|Quality of Life
Interventions: OTHER: Inspiratory Muscle Training (IMT)|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Re-Stimulated" TILs and IL-2 Therapy for Platinum Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent|Platinum-resistant|High Grade Serous Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Gou-Teng to Treat Patients With Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|White Matter Hyperintensity
Interventions: OTHER: Uncaria Rhynchophylla (Gou-Teng)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Rectus Sheath Block on the Postoperative Analgesia in the Patients Undergoing Robotic Single Port Cholecystectomy
Status: WITHDRAWN
Conditions: Gallbladder Diseases
Interventions: DRUG: denogan and rectus sheath block|DRUG: denogan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Calcium Phosphate and Incretins
Status: COMPLETED
Conditions: Healthy Men
Interventions: DIETARY_SUPPLEMENT: calcium phosphate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Time-in-range Using Continuous Glucose Monitoring Management of Gestational Diabetes Mellitus
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DIAGNOSTIC_TEST: Continuous glucose monitoring (CGM)|DIAGNOSTIC_TEST: Self-Capillary Blood Glucose Monitoring (SCBG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biomarkers for Event-driven PrEP Adherence
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: TDF/FTC Dose Schedule for Arm A|DRUG: TDF/FTC Dose Schedule for Arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Adapting an Evidenced-based Weight Management Intervention and Testing Strategies to Increase Implementation in Community Mental Health Programs
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: OTHER: training including in-person and online|OTHER: organizational strategy meetings|OTHER: performance coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effect of Chlorhexidine-benzidamine Administration
Status: COMPLETED
Conditions: Effects of Topical Chlorhexidine and Benzidine Spray
Interventions: DRUG: Chlorobenzene Liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Umbilical Cord Artery-derived Perivascular Stem Cells for the Critical Limb Ischemia Therapy
Status: RECRUITING
Conditions: Critical Limb Ischemia
Interventions: PROCEDURE: UCA-PSCs/bFGF or bFGF Intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Insect Bite Related Symptoms
Status: UNKNOWN
Conditions: Insect Bites
Interventions: DRUG: Dexchlorpheniramine 1% lotion|DRUG: Dexchlorpheniramine 1% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Costs & Outcomes of Hospitalization/Treatment With Levalbuterol & Albuterol in Asthma or Chronic Obstructive Pulmonary Disease (COPD) Subjects
Status: COMPLETED
Conditions: Asthma|COPD
Interventions: DRUG: levalbuterol HCl|DRUG: albuterol Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Safety of FG-3019 in Incipient Nephropathy Due to Type 1 or Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: FG-3019
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Karydakis Flap Versus Burow's Triangle Advancement Flap in the Surgery of Sacrococcygeal Pilonidal Sinus Disease
Status: RECRUITING
Conditions: Pilonidal Sinus|Sacrococcygeal Pilonidal Disease
Interventions: PROCEDURE: Karydakis Flap Procedure|PROCEDURE: Burow's Triangle Advancement Flap Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Caffeine Consumption on Protein Biomarkers and Cardiovascular Disease
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Caffeine Pill|DRUG: Placebo|DEVICE: TASSO+ Device|DEVICE: Finger prick and collection on Whatman Protein 903 Saver Cards|DEVICE: Intravenous Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase I Study of GZR18 Injection in Healthy Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes|Overweight and Obesity
Interventions: DRUG: GZR18|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia
Status: UNKNOWN
Conditions: Chronic Myeloproliferative Disorders|Kidney Cancer|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: filgrastim|BIOLOGICAL: graft-versus-tumor induction therapy|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: mycophenolate mofetil|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Status: RECRUITING
Conditions: Acne
Interventions: BIOLOGICAL: Acne mRNA vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aerobic Exercise and Gaming on Cognitive Performance
Status: COMPLETED
Conditions: Cognitive Performance in Healthy Volunteers
Interventions: OTHER: Aerobic exercise|OTHER: Video Gaming|OTHER: Aerobic exercise and Video Gaming|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lyon Granulomatous Hepatitis Study
Status: UNKNOWN
Conditions: Patient Diagnosed or Treated for Granulomatous Hepatitis Followed in the Internal Medicine (and or) Hepato-gastroenterology Departments
Interventions: OTHER: Evaluation of epithelioid and gigantocellular granulomas within the hepatic parenchyma by histopathology approach.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE)
Status: COMPLETED
Conditions: Critical Illness|Sepsis|Respiratory Failure|Shock|Coma|Bleeding|Trauma
Interventions: OTHER: Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Epoetin Alfa Versus Placebo in Patients With Persistent Anemia as a Result of Cancer Treatment With Cisplatin, a Platinum-containing Chemotherapy Drug
Status: COMPLETED
Conditions: Anemia|Neoplasms
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study of APR003 in Patients With Advanced Colorectal Cancer (CRC) With Malignant Liver Lesions
Status: COMPLETED
Conditions: Advanced Colorectal Carcinoma
Interventions: DRUG: APR003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Histamine and Local Heating for Evoking the Axon-reflex Flare Response in Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetic Neuropathy Peripheral|Small Fiber Neuropathy
Interventions: DIAGNOSTIC_TEST: Histamin-induced axon-reflex flare response|DIAGNOSTIC_TEST: Local heating-induced axon-reflex flare response|DIAGNOSTIC_TEST: 2-point discrimination tasks|DIAGNOSTIC_TEST: NC-Stat DPNCheck|DIAGNOSTIC_TEST: QST|DIAGNOSTIC_TEST: Biothesiometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Oxygen Inhalation on Fatigue After Chemotherapy of Breast Cancer in High Altitude Area
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: OTHER: Oxygen inhalation treatment group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PV-10 vs Chemotherapy or Oncolytic Viral Therapy for Treatment of Locally Advanced Cutaneous Melanoma
Status: TERMINATED
Conditions: Cutaneous Melanoma
Interventions: DRUG: PV-10 (10% rose bengal disodium)|DRUG: Dacarbazine, temozolomide or talimogene laherparepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Morcellator Versus Resectoscope in the Treatment of Uterine Polyps by Hysteroscopy
Status: COMPLETED
Conditions: Endometrial Polyps
Interventions: PROCEDURE: Hysteroscopic morcellation|PROCEDURE: Standard hysteroscopic resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of SPH5030 Tablets in the Treatment of Her2-positive/Mutated Biliary Tract OR Colorectal Cancer Patients.
Status: RECRUITING
Conditions: Biliary Tract or Colorectal Cancer With Her2-positive/Mutated
Interventions: DRUG: SPH5030
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of Mindfulness Versus Group Support for Treatment of Low Sexual Desire in Women
Status: COMPLETED
Conditions: Low Female Sexual Desire
Interventions: BEHAVIORAL: Mindfulness-based treatment|BEHAVIORAL: Sex therapy, education, and support treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Antiviral Activity of ANA598 Administered in Combination With Pegylated Interferon and Ribavirin for the Treatment of Genotype-1 Chronic HCV Infection
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: placebo|DRUG: ANA598|DRUG: ANA598|DRUG: Peginterferon|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty
Status: COMPLETED
Conditions: Astigmatism
Interventions: PROCEDURE: INTRASTROMAL CORNEAL RING SEGMENT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cannabinoids on Appetite in Scleroderma
Status: RECRUITING
Conditions: Systemic Sclerosis|Malnutrition|Loss of Appetite
Interventions: DRUG: CBD oil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neonatal Resuscitation in Zambia
Status: COMPLETED
Conditions: Asphyxia Neonatorum|Neonatal Mortality|Hypoxic Ischemic Encephalopathy
Interventions: PROCEDURE: Neonatal Resuscitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Influence of G-CSF and EPO on Associative Learning and Motor Skills
Status: COMPLETED
Conditions: Chronic Stroke|Amyotrophic Lateral Sclerosis
Interventions: DRUG: granulocyte - colony stimulating factor (G-CSF)|DRUG: erythropoetin (EPO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety of HPN (Hyperion)-100 for the Long-Term Treatment of Urea Cycle Disorders (Treat UCD)
Status: COMPLETED
Conditions: Urea Cycle Disorders
Interventions: DRUG: HPN-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study
Status: UNKNOWN
Conditions: Tricuspid Valve Insufficiency|Sick Sinus Syndrome
Interventions: DEVICE: LV pacing|DEVICE: RV pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Peer Support for Homelessness in the Emergency Department
Status: TERMINATED
Conditions: Homelessness|Health Behavior|Health Care Utilization|Health Care Seeking Behavior
Interventions: BEHAVIORAL: Peer Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants
Status: COMPLETED
Conditions: Infectious Disease
Interventions: DRUG: Acalabrutinib|DRUG: Rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Neoadjuvant Proton Beam Radiotherapy With Concurrent Chemotherapy in Locally Advanced Esophageal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophageal Cancer
Interventions: RADIATION: 18F-FDG (Fluorodeoxyglucose) PET|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of keepMED Positive Airway Pressure Device in Patients With Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: keepMED PAP device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CURATE.Dtx as a Diagnostic and Management Tool for Delirium
Status: NOT_YET_RECRUITING
Conditions: Delirium
Interventions: DEVICE: CURATE.Dtx|DEVICE: Optional games
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY