pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Efficacy and Patient Tolerance of Ultrathin Nasal Endoscopy to Detect Barrett's Oesophagus
Status: COMPLETED
Conditions: Barrett's Esophagus|Dyspepsia
Interventions: PROCEDURE: Transnasal Endoscopy|DEVICE: Office-based disposable transnasal endoscopy Endosheath|DEVICE: Standard upper GI endoscopy|PROCEDURE: Esophageal biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Palatal Implants in Combination With Continuous Positive Airway Pressure to Treat Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DEVICE: Pillar Palatal Implant System|DEVICE: Sham system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reactogenicity and Immunogenicity of Cervico-vaginal CN54gp140-hsp70 Conjugate Vaccine
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: CN54gp140 glycoprotein-hsp70 conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy
Status: NOT_YET_RECRUITING
Conditions: Endometrial Cancer
Interventions: DRUG: Sacituzumab govitecan-hziy|DRUG: Doxorubicin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Computer-Based Functional Skills Assessment and Training Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Healthy Aging
Interventions: DEVICE: The Computerized Functional Skills Assessment and Training Program|DEVICE: Brain HQ Double Decision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Rituximab, Bendamustine (RB) for Patients With Follicular Lymphoma Refractory or Relapsed After Treatment With R-chemotherapy in First Line
Status: UNKNOWN
Conditions: Follicular Non-Hodgking´s Lymphoma Refractory or Relapsed After Treatment With R-chemotherapy in First Line.
Interventions: DRUG: Rituximab and Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Metformin Effect on Methylglyoxal in Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin Hydrochloride (500-mg capsule)|DRUG: Calcium carbonate (placebo)|OTHER: Glucometer (One Touch glucometer), strips and lancets|OTHER: Urine container for 24-hour urine collection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research on Human Insulin rDNA Safety and Efficacy in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Adverse Drug Event|Effect of Drug|Type 2 Diabetes Treated With Insulin
Interventions: DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria（PNH）
Status: RECRUITING
Conditions: Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: HSK39297
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Telmisartan 80 mg Plus Hydrochlorothiazide 12.5 mg to Telmisartan 80 mg in Patients Failed in Telmisartan 80 mg
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan/HCTZ|DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Non-ablative Er:Yttrium Aluminum Garnet Laser for Stress Urinary Incontinence (SUI)
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: laser|DEVICE: sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mortality Risk Estimation in Acute Calculous Cholecystitis: Beyond the Tokyo Guidelines
Status: COMPLETED
Conditions: Acute Calculous Cholecystitis
Interventions: PROCEDURE: CHOLECYSTECTOMY|PROCEDURE: PERCUTANEOUS CHOLECYSTOSTOMY|PROCEDURE: EXCLUSIVE ANTIBIOTICS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation
Status: UNKNOWN
Conditions: Sick Sinus Syndrome|Brady-Tachy Syndrome
Interventions: DEVICE: Pacemaker Vitatron Selection 9000|DEVICE: Pacemaker Vitatron T70
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: KNA Proof-of-Concept
Status: COMPLETED
Conditions: Adherence, Treatment|Retention|Cognitive Impairment, Mild
Interventions: BEHAVIORAL: Motivational Interviewing-Cognitive Behavioral Therapy Ketogenic Nutrition Adherence Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Everolimus Combined With First-line Endocrine Therapy for HR+/HER2- SNF1-subtype Advanced Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Advanced Breast Cancer
Interventions: DRUG: Everolimus 10 mg|DRUG: CDK4/6 Inhibitor SHR6390|DRUG: Aromatase inhibitor and Fulvestrant combined with CDK4/6 inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ultrasound-Guided Multifidus Cervicis Plan Block Vs Greater Occipital Nerve Block for Cervicogenic Headache
Status: COMPLETED
Conditions: Cervicogenic Headache
Interventions: PROCEDURE: Ultrasound-guided nerve block for headache management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Duloxetine Delayed-Relase Capsules 60 mg Under Fed Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Duloxetine|DRUG: Cymbalta®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Recurrent or Refractory Hodgkin's or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: carmustine|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: mesna|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of Autologous Bone Marrow Derived Stem Cell Transplantation In Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: stem cell harvest|PROCEDURE: angiographic transplantation of stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NIAGEN and Persistent Chemotherapy-Induced Peripheral Neuropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Chemotherapy-induced Peripheral Neuropathy
Interventions: DRUG: Nicotinamide riboside|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caudal Dexmetedomedine Versus Magnesium in Orthopedic Pediatric Surgeries
Status: UNKNOWN
Conditions: Pain in Pediatric Patients
Interventions: DRUG: Magnesium Sulfate|DRUG: Dexmetedomedine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Evaluation of Gemcitabine- Rituximab-Oxaliplatin Combination (GROC) in Relapsed Aggressive Lymphomas
Status: COMPLETED
Conditions: Refractory Aggressive Non-Hodgkin's Lymphoma|Relapsing Aggressive Non-Hodgkin's Lymphoma
Interventions: DRUG: Rituximab, Gemcitabine, Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normalization of Morning Testosterone Levels in Men With Secondary Hypogonadism
Status: COMPLETED
Conditions: Secondary Hypogonadism
Interventions: DRUG: Placebo|DRUG: topical testosterone|DRUG: Androxal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)
Status: RECRUITING
Conditions: Colorectal Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: 5-fluorouracil|DRUG: Irinotecan|BIOLOGICAL: Bevacizumab|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Xisomab 3G3 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: xisomab 3G3- Dose 1|DRUG: xisomab 3G3-Dose 2|DRUG: xisomab 3G3-Dose 3|DRUG: xisomab 3G3- Dose 4|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Diabetic Macular Edema and Retinal Vein Occlusion
Status: COMPLETED
Conditions: Diabetic Macular Edema|Retina Vein Occlusion
Interventions: DRUG: GB-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4%
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Dapsone Topical Gel + adapalene gel 0.1%|DRUG: Dapsone Topical Gel + benzoyl peroxide gel 4%|DRUG: Dapsone Topical Gel + vehicle control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Use of Very Low Calorie Diet Preoperatively to Bariatric Surgery
Status: RECRUITING
Conditions: Bariatric Surgery Candidate|Very Low Calorie Diet|Weight Loss
Interventions: DIETARY_SUPPLEMENT: VLCD|DIETARY_SUPPLEMENT: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Acute Kidney Injury in Patients With NSTEMI
Status: TERMINATED
Conditions: Non-ST Elevation Myocardial Infarction (NSTEMI)
Interventions: DRUG: conestat alfa or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Remifentanil Versus Propofol for TCI Sedation of Patients Undergoing Gastrointestinal Endoscopic Procedures
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Remifentanil|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nitrate Consumption and Gingival Inflammation
Status: COMPLETED
Conditions: Gingivitis
Interventions: DIETARY_SUPPLEMENT: nitrate-rich lettuce juice|DIETARY_SUPPLEMENT: nitrate-depleted lettuce juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pulse Width on Scar Treatment Using a 595-nm Pulsed Dye Laser
Status: COMPLETED
Conditions: Keloids|Hypertrophic Scars
Interventions: DEVICE: Pulsed dye laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Eszopiclone in the Treatment of Insomnia and Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Insomnia
Interventions: DRUG: Eszopiclone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beetroot Juice and Postprandial Vascular Activity
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: Beetroot Juice with oral fat load|DIETARY_SUPPLEMENT: Carbohydrate control drink with oral fat load
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET/CT Imaging of Small Cell Lung Cancer Using 89Zr-DFO-SC16.56
Status: RECRUITING
Conditions: Small Cell Lung Cancer|Small Cell Lung Carcinoma
Interventions: DRUG: 89Zr-DFO-SC16.56|DRUG: SC16.56, Phase I, Cohort 2|DRUG: SC16.56, Phase I, Cohort 3|DRUG: SC16.56, Phase II
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects
Status: COMPLETED
Conditions: Chronic Constipation
Interventions: DRUG: polyethylene glycol|DRUG: Bisacodyl|DRUG: Prucalopride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
Status: RECRUITING
Conditions: Anemia|Post-essential Thrombocythemia Myelofibrosis|Post-polycythemia Vera Myelofibrosis
Interventions: DRUG: INCB000928|DRUG: ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remembering Risk: Using Visual Risk Display of MINS to Obtain Informed Consent to Undergo Elective Surgery
Status: UNKNOWN
Conditions: Risk
Interventions: OTHER: Visual Aid|OTHER: Scripted Risk Discussion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: DEXTENZA VS. PREDNISOLONE ACETATE 1% Macular Edema With Diabetic Retinopathy After Cataract Surgery
Status: UNKNOWN
Conditions: Retinopathy, Diabetic
Interventions: DRUG: Prednisolone Acetate 1% Ophthalmic Suspension [PRED FORTE]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise Augmented CBT for GAD
Status: ACTIVE_NOT_RECRUITING
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy|BEHAVIORAL: Physical Exercise|BEHAVIORAL: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Access the Safety and Effects of Intravenous Administration of AMX-818 Alone and in Combination With Pembrolizumab in Adult Participants With Locally Advanced or Metastatic HER2-Expressing Cancers
Status: RECRUITING
Conditions: Locally Advanced or Metastatic HER2-Expressing Cancers
Interventions: DRUG: AMX-818|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Toripalimab and Neoadjuvant Chemoradiotherapy in Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma by AJCC V8 Stage|Resectable Esophageal Cancer
Interventions: DRUG: Toripalimab|DRUG: Paclitaxel/cisplatin|RADIATION: Intensity-modulated radiotherapy|PROCEDURE: Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Prone Position for Spinal Surgery on Visual Acuity
Status: NOT_YET_RECRUITING
Conditions: Vision; Disorder, Loss
Interventions: PROCEDURE: Desflurane Group|PROCEDURE: Propofol Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy
Status: COMPLETED
Conditions: Dexamethasone|Glucocorticoids|Mastectomy|Breast Cancer|Pain, Postoperative|Nausea and Vomiting, Postoperative|Steroid|Systemic Inflammatory Response Syndrome|Postoperative Complications
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Identify Barriers to Cellular Therapies for People With Plasma Cell Disorders
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: Lecture on the role of cellular therapies in relapse/refractory multiple myeloma/RRMM|BEHAVIORAL: Hospital Anxiety and Depression Scale|BEHAVIORAL: Duke-UNC Functional Social Support Questionnaire|BEHAVIORAL: Distress Thermometer|BEHAVIORAL: FACT-BMT|BEHAVIORAL: Psychosocial Assessments of Candidates for Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A PALG Prospective Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) and Two Standard Salvage Regimens (FLAG-IDA vs CLAG-M) in AML Patients ≤ 60 Years Old
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: A arm (DA-90)|DRUG: B arm (DAC)|DRUG: A arm (CLAG-M)|DRUG: B arm (FLAG-IDA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nefopam Versus Ondansteron for Prevention of Post Spinal Shivering.
Status: UNKNOWN
Conditions: Shivering|Adverse Effects in the Therapeutic Use of Anaesthetic
Interventions: DRUG: Ondansetron 8mg|DRUG: Nefopam Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intergenerational mHealth Diabetes Program OPPORTUNITIES PROGRAM IN TAIWAN
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Intergenerational Mobile Technology Opportunities Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assess the Immunogenicity of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine
Status: COMPLETED
Conditions: Infections, Streptococcal|Streptococcus Pneumoniae Vaccines
Interventions: BIOLOGICAL: Pneumococcal (vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: NuShield/Affinity for the Treatment of Neuropathic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Foot Ulcer, Diabetic
Interventions: OTHER: NuShield|OTHER: Affinity|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Tranexamic Acid (TXA) in Hip Fractures
Status: COMPLETED
Conditions: Hip Fracture|Anemia
Interventions: DRUG: Tranexamic Acid|OTHER: Saline Wash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-Pulsed Dye Laser and Intense Pulsed Light for Skin Rejuvenation.
Status: TERMINATED
Conditions: Photodamaged Skin
Interventions: DEVICE: Pulsed dye laser, Intense pulsed light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose:
Clinical trial: Independent and Combined Effects of Resistance Exercise Training and β-hydroxy β-methylbutyrate Plus Vitamin D
Status: UNKNOWN
Conditions: Aging|Skeletal Muscle
Interventions: BEHAVIORAL: Non-Exercise Control|BEHAVIORAL: Resistance Exercise Training|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: HMB+VitD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Structural Modification Effect of Diacerein (Artrodar®) in Knee Osteoarthritic Patients
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Artrodar|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of AFQ056 in Fragile X Patients
Status: COMPLETED
Conditions: Fragile X Syndrome
Interventions: DRUG: AF056|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant
Status: RECRUITING
Conditions: ST Segment Elevation Myocardial Infarction|Left Ventricular Thrombus
Interventions: DRUG: Rivaroxaban|DRUG: Vitamin K Antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: OTHER: Evaluation of global longitudinal strain using routinely recorded echocardiography images
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury
Status: RECRUITING
Conditions: Disorder of Consciousness|Consciousness, Loss of|Trauma, Brain|Traumatic Brain Injury|Acute Brain Injury
Interventions: DIAGNOSTIC_TEST: SeeMe|DIAGNOSTIC_TEST: Coma Recovery Scale-Revised (CRS-R)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal Diseases in Uvira, Democratic Republic of Congo
Status: COMPLETED
Conditions: Cholera|Diarrhea
Interventions: OTHER: Improved water supply
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Testing the Use of Nilotinib and Paclitaxel as a Treatment for Patients With Prior Taxane Treatment, A ComboMATCH Treatment Trial
Status: SUSPENDED
Conditions: Metastatic Malignant Solid Neoplasm|Refractory Malignant Solid Neoplasm
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Nilotinib Hydrochloride Monohydrate|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES)
Status: COMPLETED
Conditions: Candidiasis, Invasive|Candidemia
Interventions: DRUG: SCY-078
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence and Radiologists at Prostate Cancer Detection in MRI: The PI-CAI Challenge
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Histopathology and Magnetic Resonance Imaging with Follow-Up|DIAGNOSTIC_TEST: Histopathology and Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Regorafenib and Pembrolizumab in Treating Participants With Advanced or Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Colorectal Cancer Metastatic
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions
Status: COMPLETED
Conditions: Peripheral Vascular Disease|Intermittent Claudication|Critical Limb Ischemia
Interventions: DEVICE: Everflex 200
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Set up for in-Vivo Measurement of Dynamic Intraocular Pressure (IOP)
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DEVICE: phacoemulsifcation|DEVICE: phacoemulsifcation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy
Status: COMPLETED
Conditions: Lean Body Mass|Cannabis|Cancer|Nausea|Cachexia|Emesis|Appetitive Behavior
Interventions: DRUG: Cannabidiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Intraocular Concentrations (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Endophthalmitis
Interventions: OTHER: Pharmacokinetic and pharmacodynamic study of antibiotics used in severe endophthalmitis from samples taken from treated patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Itraconazole and Ticlopidine on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol
Status: COMPLETED
Conditions: Pharmacokinetics|Pharmacodynamics
Interventions: DRUG: Placebo|DRUG: Ticlopidine|DRUG: Ticlopidine and itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study to Evaluate Z7200 Pharmacokinetics Profile
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Z7200 without oral activated charcoal|DRUG: Symbicort Turbohaler without oral activated charcoal|DRUG: Z7200 with oral activated charcoal|DRUG: Symbicort Turbohaler with oral activated charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Present- Versus Past-focused Therapy for PTSD and Substance Use Disorder
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder|Substance Use Disorder|Alcohol Use Disorder
Interventions: BEHAVIORAL: Creating Change (CC)|BEHAVIORAL: Seeking Safety (SS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy of CREWS01 to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults
Status: NOT_YET_RECRUITING
Conditions: Asthma
Interventions: DRUG: Antipyrine-benzocaine otic solution|OTHER: Glycerin with Oxyquinoline Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detection and Classification of Diabetic Retinopathy From Posterior Pole Images With A Deep Learning Model
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Eye Problems|Diabetic Macular Edema
Interventions: PROCEDURE: Color Fundus Photography|DRUG: Mydriatic Agent|DEVICE: EyeCheckup - AI Based DR Screening
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Research Study of How Safe a New Medicine Called NNC0519 0130 is and to Test Its Effect in People Living With Excess Body Weight With or Without Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Obesity
Interventions: DRUG: NNC0519-0130|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1
Status: NOT_YET_RECRUITING
Conditions: Neurofibromatosis 1|Plexiform Neurofibroma
Interventions: DRUG: Selumetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trichuris Suis Ova Therapy for Relapsing Multiple Sclerosis - a Safety Study
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: BIOLOGICAL: Trichuris suis ova
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controller Medications in the Management of Bronchial Asthma
Status: COMPLETED
Conditions: Moderate to Severe Persistent Bronchial Asthma
Interventions: DRUG: inhaled budesonide and formeterol plus oral montelukast|DRUG: inhaled budesonide and formeterol plus oral doxophylline|DRUG: Doubling the dose of inhaled budesonide and formeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of GZR33 and GZR101 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: GZR33 Injection|DRUG: GZR101 Injection|DRUG: Placebo|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Sildenafil Protect Against Pulmonary Related Complications Following Cardiopulmonary Bypass?
Status: UNKNOWN
Conditions: Cardiopulmonary Bypass
Interventions: DRUG: Sildenafil Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of IV Cangrelor and Oral Ticagrelor Study
Status: COMPLETED
Conditions: Acute Coronary Syndrome (ACS)|High On-treatment Platelet Reactivity (HTPR)|Microvascular Obstruction (MVO)|ST-segment Elevation Myocardial Infarction (STEMI)|Thrombolysis in Myocardial Infarction (TIMI)|Unstable Angina (UA)
Interventions: DRUG: Cangrelor|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pericervical Analgesia Versus Analesia With Nitrous Oxide (N2O) in Outpatien Operative Hysteroscopy With Miniresector
Status: COMPLETED
Conditions: Hysteroscopy
Interventions: DRUG: Intervention Group: pericervical anesthesia|OTHER: Nitroux Oxide anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Time to Start Breast Milk Fortifiers on Neonatal Outcomes in Very Low Birth Weight Premature Infants.
Status: UNKNOWN
Conditions: Breast Milk Fortifier Supplements|Premature
Interventions: DIETARY_SUPPLEMENT: Breast Milk Fortifier supplements
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prebiotics in Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: DIETARY_SUPPLEMENT: Soluble Corn Fiber|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation
Status: TERMINATED
Conditions: Chronic Myeloproliferative Disorders|Graft Versus Host Disease|Leukemia|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: busulfan|DRUG: cyclophosphamide|DRUG: cyclosporine|DRUG: leucovorin calcium|DRUG: methotrexate|DRUG: methylprednisolone|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: in vitro-treated bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Impact of Severe Hepatic Impairment on Pharmacokinetics of Cenicriviroc and Its Metabolites
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Cenicriviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Seaweeds Combined With Probiotics on Intestinal Function of Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Seaweed and Duolac7S|DIETARY_SUPPLEMENT: Seaweed and Duolac7S-P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Glutathione on Immunity in Individuals Training for a Marathon
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Glutathione Supplement|DIETARY_SUPPLEMENT: Placebo Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Pandemic H5N1 Influenza
Interventions: BIOLOGICAL: Adjuvanted H5N1 pandemic influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Kidney Health: Eat Well, Live Well
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Kidney Diseases
Interventions: BEHAVIORAL: 1. Welcome package|BEHAVIORAL: 2. Welcome information (phone or text)|BEHAVIORAL: 3. Produce delivery + Recipes customized to produce|BEHAVIORAL: 4. E-gift cards to a grocery store of choice|BEHAVIORAL: 5. Personalized practical & emotional support through a dedicated health partner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study To Assess The Effects Of A Single Dose Of GSK598809 In Modulating Nicotine Reward
Status: COMPLETED
Conditions: Substance Dependence
Interventions: DRUG: GSK598809
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NPC - AXEL Study : Axitinib-Avelumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent or Metastatic NPC
Interventions: DRUG: Axitinib|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Celecoxib Versus Diclofenac in the Treatment of Ankylosing Spondylitis
Status: COMPLETED
Conditions: Spondylitis, Ankylosing
Interventions: DRUG: Celecoxib|DRUG: Celecoxib|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy
Status: TERMINATED
Conditions: Iron Overload Due to Repeated Red Blood Cell Transfusions
Interventions: DRUG: SPD602
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Lung Impedance Guided Preemptive Therapy of Chronic Heart Failure Patients With Preserved Ejection Fraction (LVEF ≥ 45%) in Our Hospital's Outpatient Clinic
Status: UNKNOWN
Conditions: Heart Failure
Interventions: OTHER: LI-Guided Therapy|OTHER: Heart Failure Guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Follow-up Study on the Antibody Response to Hepatitis B, Acellular Pertussis Toxin and Inactivated Poliovirus Antigens 1 Month After the 4th Hexavac® Vaccination in Healthy Children, Who Participated in NeisVac-C Study 216
Status: COMPLETED
Conditions: Meningococcal Meninigitis, Serogroup C
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Glenoid Component Position Using Intelligent Reusable Instrument (IRI) vs Standard Surgical Instruments
Status: COMPLETED
Conditions: Anatomic Total Shoulder Arthroplasty
Interventions: DEVICE: Anatomic TSA using IRI Instrumentation|PROCEDURE: Anatomic Total Shoulder Arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of the Opioid System in Placebo Effects on Pain and Social Rejection
Status: NOT_YET_RECRUITING
Conditions: Pain|Rejection|Placebo Effect
Interventions: DRUG: Placebo Cream with Naloxone|DRUG: Control Cream with Naloxone|DRUG: Placebo Cream with Saline|DRUG: Control Cream with Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Status: COMPLETED
Conditions: Endothelial Dysfunction|Aging
Interventions: DIETARY_SUPPLEMENT: Aronia full spectrum - half dose|DIETARY_SUPPLEMENT: Aronia full spectrum - full dose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Detection of an Endovascular Treatment Target in Patients With an Acute, Spontaneous Intracerebral Hemorrhage
Status: RECRUITING
Conditions: Intracerebral Hemorrhage|Nontraumatic Intracerebral Hemorrhage
Interventions: DIAGNOSTIC_TEST: Diagnostic, cerebral Digital Subtraction Angiography (DSA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer
Status: SUSPENDED
Conditions: Breast Adenocarcinoma|Metastatic Breast Carcinoma|Recurrent Breast Carcinoma|Recurrent Hodgkin Lymphoma|Recurrent Mycosis Fungoides|Recurrent Non-Hodgkin Lymphoma|Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Refractory Breast Carcinoma|Refractory Hodgkin Lymphoma|Refractory Mycosis Fungoides|Refractory Nodal Marginal Zone Lymphoma|Refractory Non-Hodgkin Lymphoma|Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Belinostat|DRUG: Carfilzomib|DRUG: Copanlisib Hydrochloride|BIOLOGICAL: Daratumumab|DRUG: Fludeoxyglucose F-18|DRUG: Gemcitabine Hydrochloride|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|BIOLOGICAL: Obinutuzumab|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Rituximab|DRUG: Romidepsin|OTHER: Saline|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: NRTIs (ABC, FTC, FTC/TDF, 3TC, 3TC/AZT, d4T, TDF, ddC, AZT)|DRUG: NNRTIs (EFV, NVP)|DRUG: PIs (AMP, IDV, LPV/r, NFV, SQV, RTV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficiency of a Jellyfish Sting Inhibitor Sun Lotion and Protocols for Jellyfish Sting Pain Relief
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: Safe Sea sun lotion with jellyfish sting protection SPF 15|OTHER: Nivea sun, caring sun lotion SPF 15
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of McGrath Series 5 and Airtraq Videolaryngoscope for Double-lumen Tube (DLT) Intubation
Status: COMPLETED
Conditions: Intubation;Difficult|Thoracic Disease|Intubation Complication
Interventions: DEVICE: McGrath Series 5|DEVICE: Airtraq
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Nalmefene in Patients With Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Placebo|DRUG: Nalmefene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy Plus Sequential Immune Checkpoint Inhibitor (ICI) Therapy in Locally Advanced Colon Cancer
Status: NOT_YET_RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: Serplulimab|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Dose Finding, PK/PD and 12 Month Exploratory Efficacy Study of ANAVEX2-73 in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ANAVEX2-73 Oral|DRUG: ANAVEX2-73 Intravenous|DRUG: ANAVEX2-73 Oral|DRUG: ANAVEX2-73 Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Tobacco Treatment in Primary Care (MOTIVATE)
Status: RECRUITING
Conditions: Physician's Role|Smoking Cessation|Smoking
Interventions: BEHAVIORAL: Precision Treatment|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Can Dexmedetomidine For Procedural Sedation In Knee Arthroplasty Reduce Postoperative Pain? A Randomized Control Study
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria.
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: DRUG: Artemether-lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lactobacillus Brevis CD2 in Prevention of Radio-chemotherapy Induced Oral Mucositis in Head and Neck Cancer
Status: UNKNOWN
Conditions: Mucositis
Interventions: DIETARY_SUPPLEMENT: CD#2|OTHER: bicarbonate sodium mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation and Implementation Preparation of a Proactive Palliative Care Model (ENABLE-SG)
Status: RECRUITING
Conditions: Neoplasms
Interventions: BEHAVIORAL: ENABLE-SG model|OTHER: Wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Point of Care Tests to Identify Opportunistic Infections in Advanced HIV Patients in Mexico City
Status: NOT_YET_RECRUITING
Conditions: Acquired Immunodeficiency Syndrome|Histoplasmosis AIDS|Tuberculosis Infection|Cryptococcal Meningitis
Interventions: DIAGNOSTIC_TEST: Histoplasma Urine Antigen Lateral Flow Antigen test|DIAGNOSTIC_TEST: Cryptococcal Lateral Flow Antigen test|DIAGNOSTIC_TEST: Tuberculosis-lipoarabinomannan Lateral Flow Antigen test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Angeliq on Blood Pressure (BP) in Postmenopausal Hypertensive Women
Status: COMPLETED
Conditions: Hypertension|Postmenopause
Interventions: DRUG: Angeliq (Drospirenone/17ß-estradiol, BAY86-4891)|DRUG: Angeliq (Drospirenone/17ß-estradiol, BAY86-4891)|DRUG: Angeliq (Drospirenone/17ß-estradiol, BAY86-4891)|DRUG: Angeliq (Drospirenone/17ß-estradiol, BAY86-4891)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Colon Cancer Treatment Decisions and Recurrence Predicting
Status: UNKNOWN
Conditions: Colonic Neoplasms
Interventions: BIOLOGICAL: OncoCare|DRUG: chemotherapy for colorectal carcinoma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Surgical Prehabilitation in Abdominal Surgery
Status: COMPLETED
Conditions: Older People|Prehabilitation|Surgical Procedure
Interventions: BEHAVIORAL: Multimodal prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE