pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Vemurafenib|DRUG: Cobimetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Ginger Extract Consumption on Risk Markers of Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Ginger drink|DIETARY_SUPPLEMENT: Placebo: Super pure water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The BioRythm Guided Weight Loss Study Will Test a Novel Behavioral Health Intervention Combined With Fitbit Technology Monitoring in Obese Individuals to Determine if it Promotes Weight Loss, Improves Objective Measures of Sleep Health, and Aids in Developing a Consistent Mealtime Routine
Status: UNKNOWN
Conditions: Obesity
Interventions: BEHAVIORAL: The Circadian Rhythm Approach to Weight Loss (CRAWL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dark Chocolate, Coconut Water, and Ibuprofen in Managing Primary Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea Primary|Menstrual Pain|Ibuprofen
Interventions: DRUG: Ibuprofen 400 mg|OTHER: Young Coconut Water|OTHER: Dark Chocolate Bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating 13 Valent Pneumococcal Conjugate Vaccine With Trivalent Inactivated Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: 13 valent pneumococcal conjugate vaccine|BIOLOGICAL: 13 valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PostureCheck: A Vision-based Compensatory-posture-detection Tool for Robot-assisted Upper-limb Therapy
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: BURT|DEVICE: BURT + PostureCheck
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluorouracil, Cisplatin, Leucovorin Calcium, and Cetuximab in Treating Patients With Adenocarcinoma of the Stomach or Gastroesophageal Junction
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Gastric Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: cisplatin|DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: quality-of-life assessment|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-PD-1 Re-challenge After Immune Priming by Ipilimumab and Immune Boosting by Radiotherapy in Advanced NSCLC
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Ipilimumab|DRUG: Cemiplimab|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The StepSmart Project: A Pedometer Based Phased Intervention to Encourage Physical Activity in Schools
Status: COMPLETED
Conditions: Physical Activity|Health Behavior|Competitive Behavior|Incentives
Interventions: BEHAVIORAL: The StepSmart Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 18-month Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral UCB0599 in Study Participants With Early-stage Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Early-stage Parkinson's Disease
Interventions: DRUG: UCB0599|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm B (Fluvoxamine)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Fluvoxamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke
Status: RECRUITING
Conditions: Chronic Hemiparetic Stroke
Interventions: BEHAVIORAL: High intensity gait training in varying external environments|BEHAVIORAL: Treadmill walking in varying external environments
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clear Aligner Versus Removable Inclined Plane in Treatment of Anterior Crossbite
Status: RECRUITING
Conditions: Anterior Crossbite
Interventions: OTHER: inclined plane|OTHER: clear aligner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Home-based RCTs of Pilates Exercises and Cognitive Rehabilitation Exercises for Executive Functions and Anxiety in MS.
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Home-Based Pilates exercise|OTHER: Home-based Cognitive Rehabilitation|OTHER: waiting list group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Study of Cang Ai Volatile Oil (CAVO) on Mild to Moderate Depression in Children and Adolescents
Status: RECRUITING
Conditions: Depression
Interventions: DRUG: CAVO aromatherapy patch at 3% concentration+Fluoxetine hydrochloride mimetic|DRUG: Fluoxetine hydrochloride tablet+CAVO aromatherapy patch at 0.1% concentration|DRUG: Fluoxetine hydrochloride mimetic+CAVO aromatherapy patch at 0.1% concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Neoplasm|Recurrent Brain Neoplasm
Interventions: PROCEDURE: Cognitive Assessment|OTHER: Computer-Assisted Cognitive Training|PROCEDURE: Psychosocial Assessment and Care|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: I-124 PET/CT Based Remnant Radioiodine Ablation Decision Concept in Differentiated Thyroid Cancer
Status: RECRUITING
Conditions: Differentiated Thyroid Carcinoma
Interventions: RADIATION: Radioiodine I-131|RADIATION: I-124
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids in Children and Adolescents With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Flax oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ONO-1101 in Patients Scheduled for Multi-Slice Computed Tomography (CT)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: ONO-1101|DRUG: ONO-1101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Rotational Insertion Technique for ProSeal Laryngeal Mask Airway
Status: COMPLETED
Conditions: General Anesthesia|Elective Surgery
Interventions: PROCEDURE: Insertion fo ProSeal laryngeal mask airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Validation of SHADE a Mobile Technology for Monitoring of Ultraviolet Exposure
Status: COMPLETED
Conditions: Skin Cancer|Actinic Keratoses|Ultraviolet-Induced Change in Normal Skin|Behavior, Health|Behavior, Risk Reduction
Interventions: DEVICE: SHADE Ultraviolet Sensor|BEHAVIORAL: Standard of care counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drug Interaction Study of Isavuconazole and Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Pharmacokinetics of Ethinyl Estradiol and Norethindrone|Healthy Volunteers
Interventions: DRUG: isavuconazole|DRUG: Oral Contraceptive (ethinyl estradiol / norethindrone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Acceleration of Lower Anterior Teeth Leveling and Alignment Using Corticision
Status: COMPLETED
Conditions: Crowding, Tooth
Interventions: DEVICE: Traditional fixed appliance|PROCEDURE: Corticision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting and Piloting Behavioral Activation for Veterans With Alcohol Use Disorder and Posttraumatic Stress Disorder
Status: RECRUITING
Conditions: Alcohol Use Disorder|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Behavioral Activation (BA)|BEHAVIORAL: Relapse Prevention (RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Function, Pain, and Alignment Following Knee Replacement for the Treatment of Osteoarthritis
Status: UNKNOWN
Conditions: Knee Replacement, Total|Pain, Postoperative|Functional Independence
Interventions: PROCEDURE: Total Knee Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Neoadjuvant Pembrolizumab & Lenvatinib for Resectable Stage III Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma Stage III
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Insulin Protocol in Diabetes and Renal Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation|Diabetes|Hyperglycemia
Interventions: DRUG: insulin|DRUG: NPH Insulin or glargine insulin and aspartame insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating an Exercise and Education Programme for Individuals With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Spondylitis, Ankylosing
Interventions: OTHER: Exercise and Education|OTHER: Exercise and Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medico-economic Study of Three Strategies of Sentinel Lymph Node Analysis in Operable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Surgery
Interventions: PROCEDURE: SLN detection +/- complementary axillary lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Performance of Low Technique Sensitive Self Cured Universal Adhesive Vrs Light Cured Universal Adhesive in Patients With (NCCLs): 18 m RCT
Status: UNKNOWN
Conditions: Non Carious Cervical Lesion
Interventions: OTHER: light cure 3m single bond universal bond|OTHER: Self-cure universal bond (Palfique, Tokuyama, Japan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Study of Nateglinide+Valsartan to Prevent or Delay Type II Diabetes Mellitus and Cardiovascular Complications
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Valsartan 160 mg + nateglinide 60 mg|DRUG: Valsartan 160 mg + nateglinide placebo|DRUG: Nateglinide 60 mg + valsartan placebo|DRUG: Valsartan placebo + nateglinide placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intraoperative Methadone in Children Undergoing Surgery
Status: TERMINATED
Conditions: Pain, Acute|Pain, Postoperative|Children, Only
Interventions: DRUG: Methadone Hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of GSE and Xylitol (Xlear) on COVID-19 Symptoms and Time to PCR Negativisation in COVID-19 Patients
Status: WITHDRAWN
Conditions: Covid19
Interventions: OTHER: GSE and Xylitol|DRUG: Control Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Transcranial Alternating Current Stimulation（tACS）on Cerebellar Ataxia
Status: COMPLETED
Conditions: Spinocerebellar Ataxia Type 3|Multiple System Atrophy-cerebellar Type
Interventions: DEVICE: Transcranial Alternating Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Stimulation of Growth in Children With Short Stature
Status: COMPLETED
Conditions: Nutritional Stunting|Growth Failure
Interventions: DIETARY_SUPPLEMENT: Essential Amino Acid (EAA) group|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation Effect of Focused Ultrasound for Motor Recovery in Patients With Stroke
Status: RECRUITING
Conditions: Focused Ultrasound|Stroke
Interventions: DEVICE: NaviFUS® Neuronavigation-guided focused ultrasound system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Lung Cancer Diagnosis in HIV Infected Population With an Important Smoking History With Low Dose CT: a Pilot Study
Status: COMPLETED
Conditions: Hiv Infection|Lung Cancer
Interventions: RADIATION: Low dose computed tomography (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Phase 2, Randomized, Double-blind, Placebo Controlled Dose Ranging Study of Repeat Doses of AA4500 for the Treatment of Edematous Fibrosclerotic Panniculopathy
Status: COMPLETED
Conditions: Edematous Fibrosclerotic Panniculopathy (EFP)
Interventions: BIOLOGICAL: Collagenase Clostridium Histolyticum|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ARTERIAL EMBOLIZATION OF PERSISTENT GENICULATE ARTERIES FOR CHRONIC PAIN MANAGEMENT AFTER TOTAL KNEE-REPLACEMENT ARTHROPLASTY(KNEE EMBOLISATION)
Status: UNKNOWN
Conditions: Musculoskeletal Inflammatory
Interventions: PROCEDURE: arterial embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in High Risk for Cardiovascular Disease
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Cilostazol|DRUG: Dummy Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetics of CBT-008 in Patients With Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: CBT-008
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: Measure of visual acuity|OTHER: Interferometry|OTHER: Samples of basal tears|OTHER: Central corneal sensitivity|OTHER: Slit lamp examination and undilated fundus|OTHER: Conjunctival impression|OTHER: Evaluation of the corneal innervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Oral Calcitonin Given at Night to Healthy Postmenopausal Women
Status: COMPLETED
Conditions: Phase 1 Pharmacodynamic Study
Interventions: DRUG: Oral rsCT tablet|DRUG: Oral Placebo Tablet|DRUG: Oral rsCT tablet|DRUG: Fortical (rsCT) nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block Versus Liposomal Bupivacaine in TKA
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Post-operative Pain Control
Interventions: PROCEDURE: Liposomal Bupivacaine Peri-articular Injection|PROCEDURE: Adductor canal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation With Post-transplant Cyclophosphamide for Rescuing Patients With Graft Failure
Status: NOT_YET_RECRUITING
Conditions: Hematologic Diseases|Graft Failure|Allogeneic Hematopoietic Stem Cell Transplantation
Interventions: OTHER: haplo-SCT with PTCy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
Status: RECRUITING
Conditions: Heart Failure|Heart Failure Preserved Ejection Fraction|Cardiovascular Diseases|Heart Diseases
Interventions: DRUG: Tovinontrine (CRD-750|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azacitidine With or Without Entinostat in Treating Patients With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1|Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL|Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA|Alkylating Agent-Related Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndrome|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndrome|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Entinostat|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memantine Versus Placebo in Parkinson's Disease Dementia or Dementia With Lewy Bodies
Status: COMPLETED
Conditions: Parkinson's Disease Dementia|Dementia With Lewy Bodies
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Cutaneous Formulation of Gonyautoxin 2/3 (GTX 2/3) for the Treatment of Facial Wrinkles
Status: WITHDRAWN
Conditions: Facial Wrinkles
Interventions: OTHER: Wrinkle cream application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Immunodeficiency Virus|Smoking Cessation|Smoking, Cigarette|Smoking|Anxiety|Depression|Nicotine Dependence
Interventions: BEHAVIORAL: QUIT|BEHAVIORAL: Time-Matched Control (TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Postural Rehabilitation Program Based on Sensory-motor Control in Men With Urinary Incontinence After Prostatectomy
Status: UNKNOWN
Conditions: Urinary Incontinence|Prostate Cancer
Interventions: BEHAVIORAL: postural rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy
Status: NOT_YET_RECRUITING
Conditions: Refractory Epilepsy|Drug Resistant Epilepsy
Interventions: DRUG: Leucine-Enriched Essential Amino Acid powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Prophylactic Use of Letermovir in Kidney Transplant Recipients at Risk of Cytomegalovirus Infection
Status: NOT_YET_RECRUITING
Conditions: CMV Infection
Interventions: DRUG: Letermovir 480 MG|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide
Status: SUSPENDED
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: rifampicin|DRUG: pyrazinamide|DRUG: HRZE|DRUG: HR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of MB09 [Proposed Denosumab Biosimilar] to Prolia® [EU-sourced] in Postmenopausal Osteoporosis (SIMBA Study)
Status: COMPLETED
Conditions: Postmenopausal Women With Osteoporosis
Interventions: DRUG: MB09 (denosumab biosimilar)|DRUG: EU-Prolia|DIETARY_SUPPLEMENT: Elemental Calcium|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination, Miltefosine Monotherapy for Cutaneous Leishmaniasis in New World
Status: ACTIVE_NOT_RECRUITING
Conditions: Cutaneous Leishmaniases
Interventions: DRUG: Meglumine Antimoniate|DRUG: Miltefosine|DEVICE: Thermotherapy machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PILI 'Ohana Project: Partnerships to Overcome Obesity Disparities in Hawaii (3-Year Pilot)
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: PILI 'Ohana Lifestyle Program|BEHAVIORAL: Standard Behavioral Weight Loss Maintenance Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects Of Resistive Exercise or Proprioceptive Exercise Training Among Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: PROCEDURE: Proprioceptive Exercises|PROCEDURE: Resistive Exercises|PROCEDURE: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ventilatory Heterogeneity in Participants With Asthma (MK-0476-513)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: OTHER: Nicotine-Containing Electronic Cigarette|OTHER: Non-Nicotine Electronic Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Azithromycin Treatment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and Tracheostomy
Status: TERMINATED
Conditions: COPD|Tracheostomy
Interventions: DRUG: azithromycin (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of VEGF Trap Eye in Diabetic Macular Edema (DME) With Central Involvement
Status: COMPLETED
Conditions: Macular Edema
Interventions: BIOLOGICAL: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)|BIOLOGICAL: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)|PROCEDURE: Macular Laser Photocoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Propranolol Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery
Status: TERMINATED
Conditions: Prostate Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Propranolol Hydrochloride|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOuble SEquential External Defibrillation for Refractory VF
Status: COMPLETED
Conditions: Out-Of-Hospital Cardiac Arrest|Ventricular Fibrillation
Interventions: PROCEDURE: Double Sequential Defibrillation|PROCEDURE: Vector Change Defibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Frontosubthalamic Networks in Parkinson's Disease.
Status: RECRUITING
Conditions: Parkinson Disease|Impulse Control Disorder
Interventions: OTHER: DBS on/off
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Use of RAD001 With Docetaxel in the Treatment of Metastatic, Androgen Independent Prostate Cancer
Status: COMPLETED
Conditions: Metastatic, Androgen Independent Prostate Cancer|Prostate Cancer
Interventions: DRUG: RAD001|DRUG: Docetaxel|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary|Tuberculosis, Multidrug-Resistant|Tuberculosis, MDR|Tuberculosis|Extensively Drug-Resistant Tuberculosis|Pre-XDR-TB|XDR-TB
Interventions: DRUG: Pretomanid|DRUG: Linezolid|DRUG: Bedaquiline|DRUG: Placebo Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain and Quality of Life After Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS
Status: UNKNOWN
Conditions: Mediastinal Neoplasms|Thoracic Neoplasm|Thoracic Surgery
Interventions: PROCEDURE: Subxiphoid uniportal VATS|PROCEDURE: Intercostal uniportal VATS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurological Complications Comparing Endoscopically vs. Open Harvest of the Radial Artery
Status: COMPLETED
Conditions: Complications Due to Coronary Artery Bypass Graft|Coronary Artery Disease|Myocardial Ischemia|Coronary Disease|Heart Diseases|Cardiovascular Diseases|Arteriosclerosis|Arterial Occlusive Diseases|Vascular Diseases
Interventions: PROCEDURE: Endoscopic radial artery harvest|PROCEDURE: Open radial artery harvest|PROCEDURE: Mammarioradial graft (Y-graft)|PROCEDURE: Aortoradial graft (Free RA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety of PBCLN-003 Following Antibiotic Therapy in Subjects With C.Difficile-associated Diarrhea
Status: TERMINATED
Conditions: Clostridium Difficile Diarrhea
Interventions: DRUG: PBCLN-003|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peer Online Motivational Interviewing for Sexual and Gender Minority Male Survivors
Status: COMPLETED
Conditions: Sexual Abuse
Interventions: BEHAVIORAL: Trauma-informed SGM affirmative care|BEHAVIORAL: Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Rising Dose Study of BI 207127 NA in Healthy Male Asian Volunteers and Single Dose Study of BI 207127 NA in Healthy Male Caucasian Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Matching placebo (low dose)|DRUG: BI 207127 NA (medium dose)|DRUG: BI 207127 NA (low dose)|DRUG: Matching placebo (medium dose)|DRUG: BI 207127 NA (high dose)|DRUG: Matching placebo (high dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Visual Quality of Traditional Ultrasound Biometrics and Lenstar on the Cataract After Pars Plana Vitrectomy
Status: UNKNOWN
Conditions: Diabetic Retinopathy Patients After Vitrectomy
Interventions: DEVICE: Traditional ultrasound biometrics|DEVICE: Lenstar
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A 12-Week Study in Adult Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Propionate (FP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Changing dose of norepinephrine and blood pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes
Status: UNKNOWN
Conditions: Maturity-Onset Diabetes of the Young, Type 3|Maturity Onset Diabetes of the Young, Type 1|Childhood Diabetes Mellitus|Insulin-dependent Diabetes Mellitus
Interventions: DRUG: Sulfonylurea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ENGAGED 2 Study: Experiences With Mammography Screening and Breast Density 2
Status: COMPLETED
Conditions: Breast Density|Breast Cancer Female
Interventions: BEHAVIORAL: Usual Care Arm|BEHAVIORAL: Personalized Web Intervention Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases
Status: COMPLETED
Conditions: Colorectal Cancer|Islet Cell Tumor|Liver Cancer|Metastatic Cancer|Neuroendocrine Carcinoma
Interventions: DRUG: isolated perfusion|DRUG: melphalan|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Imaging Study on Physical Activity in Patients With Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: OTHER: Clinical-neurological and neuropsychological tests|DIAGNOSTIC_TEST: Blood sampling|OTHER: Assessment of physical activity via fitness tracker/diary|OTHER: MRI-examinations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer
Status: RECRUITING
Conditions: Locally Advanced Thyroid Gland Carcinoma
Interventions: DRUG: Anlotinib|DRUG: Lenvatinib|DRUG: Sorafenib|DRUG: Donafenib|DRUG: Everolimus|DRUG: Apatinib|DRUG: Dabrafenib + Trametinib|DRUG: Cabozantinib|DRUG: Vandetanib|DRUG: Entrectinib|DRUG: Pralsetinib|DRUG: Larotrectinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 in Adults With Congenital Adrenal Hyperplasia
Status: COMPLETED
Conditions: CAH - Congenital Adrenal Hyperplasia
Interventions: DRUG: NBI-74788
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Mindful Self-Compassion (MSC) Program
Status: RECRUITING
Conditions: Self-compassion|Mindfulness|Mental Health|Well-being|Inflammatory Response|Cardiovascular Health
Interventions: BEHAVIORAL: Mindful Self-Compassion (MSC) training|BEHAVIORAL: Mindfulness Based Stress Reduction (MBSR) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laser Lithotripsy During URS - Holmium vs Thulium
Status: COMPLETED
Conditions: Urolithiasis
Interventions: DEVICE: Holmium:YAG laser machine|DEVICE: Thulium Fiber laser machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity
Status: RECRUITING
Conditions: Bipolar Disorder|Obesity|Cognition
Interventions: DRUG: dulaglutide injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Versus 24 Hours Antibiotic Prophylaxis in Reduction Mammaplasty
Status: UNKNOWN
Conditions: Plastic Surgery|Mammaplasty|Anti-bacterial Agents|Prophylaxis|Wound Infection
Interventions: DRUG: Cephazolin|OTHER: Sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities
Status: NOT_YET_RECRUITING
Conditions: Refractive Errors
Interventions: DEVICE: Spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: When and How to Administer Oxytocin for Active Management of Third Stage of Labour
Status: COMPLETED
Conditions: Postpartum Bleeding
Interventions: DRUG: intravenous & intramuscular oxytocin|PROCEDURE: after delivery of the fetus & when anterior shoulder seen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Phase 3 Study of Tramadol Hydrochloride/Acetaminophen SR Tab. & Tramadol Hydrochloride/Acetaminophen Tab. in Acute Toothache Patients After Teeth Extraction Surgery
Status: COMPLETED
Conditions: Acute Toothache Patients Above Moderate Pain After Teeth Extraction Surgery
Interventions: DRUG: Tramadol hydrochloride/Acetaminophen Tab.|DRUG: Tramadol hydrochloride/Acetaminophen SR Tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Self-Efficacy Promoting Program Using Computer Game on Proteinuria in Thai Children With Nephrotic Syndrome
Status: COMPLETED
Conditions: Nephrotic Syndrome in Children
Interventions: BEHAVIORAL: Self-efficacy promoting program using computer game|BEHAVIORAL: Standard nursing care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Polynucleotides and Hyaluronic Acid Based Subgingival Periodontal Pockets Re-instrumentation
Status: COMPLETED
Conditions: Periodontal Pocket
Interventions: OTHER: subgingival re-instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Collaborative Power Mobility Innovative Learning OpporTunity (CoPILOT) - A Pilot Study of a New Training Approach (Phase 1)
Status: COMPLETED
Conditions: Power Wheelchair|Mild Cognitive Impairment|Spinal Cord Injuries
Interventions: BEHAVIORAL: CoPILOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Velaglucerase Alfa (VPRIV®) on Bone-related Pathology in Treatment-naïve Participants With Type 1 Gaucher Disease
Status: COMPLETED
Conditions: Gaucher Disease
Interventions: DRUG: Velaglucerase alfa|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study Evaluating Treatment Sessions of Restylane Skinboosters Vital Lidocaine in the Face
Status: COMPLETED
Conditions: Aged Skin
Interventions: DEVICE: Restylane Vital Skinboosters Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypertension Study: Multinational Torasemide Trial in Mild to Moderate Hypertension.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Torasemide Prolonged Release (loop diuretic)|DRUG: Torasemide Immediate Release (loop diuretic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: EFFICACY OF ORAL AROEIRA (Schinus Terebinthifolia Raddi) COMPARED TO OMEPRAZOLE IN DYSPEPPSIA
Status: NOT_YET_RECRUITING
Conditions: Dyspepsia
Interventions: DRUG: Oral Aroeira|DRUG: Omeprazole 20Mg Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 68Ga-PSMA-11 PET/CT Screening Prior to 177Lu-PSMA-617 Therapy for Patients With Metastatic Castrate Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Computed Tomography|DRUG: Gallium Ga 68 Gozetotide|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Processing on Food Reward
Status: RECRUITING
Conditions: Metabolic Diseases
Interventions: OTHER: Ultra-processed food - Picture Set Meal|OTHER: Ultra-processed food - Additives Meal|OTHER: Ultra-processed food - Ingredients Meal|OTHER: Minimally Processed Food - Picture Set Meal|OTHER: Minimally Processed Food - Additives Meal|OTHER: Minimally Processed Food - Ingredients Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High-intensity Training Safely Improves Exercise Capacity in Heart, Lung, Kidney, and Liver Transplant Recipients: a Comparative Study
Status: COMPLETED
Conditions: Physical Activity After Organ Transplantation
Interventions: OTHER: High-intensity training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Pharmacokinetics of Venlafaxine ER and Desvenlafaxine SR in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: desvenlafaxine SR|DRUG: venlafaxine ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcranial Direct Current Stimulation (tDCS) on the Excitability of the Diaphragmatic Primary Motor Cortex
Status: COMPLETED
Conditions: Excitability of Diaphragmatic Primary Motor Cortex
Interventions: DEVICE: Eldith DC stimulator ( Magstim Company Ltd. UK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility Assessment of Neurophysiological Measurement in Veterans With LBP
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Spinal manipulation|PROCEDURE: Therapeutic touch|PROCEDURE: fMRI|BEHAVIORAL: Pain Sensitivity Testing|OTHER: Questionnaires|BEHAVIORAL: Physical Impairment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Semaglutide on the Psoriatic Lesions in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Psoriasis Vulgaris|Diabetes Type 2
Interventions: DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fully Covered or Partially Covered Stents in Malignant Esophageal Strictures
Status: COMPLETED
Conditions: Esophageal Cancer|Esophageal Stenosis
Interventions: DEVICE: Partially covered SEMS|DEVICE: Fully covered SEMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Knee Osteoarthritis|Knee Arthritis|Knee Pain Chronic
Interventions: BIOLOGICAL: 4 mL injection of Ampion|DRUG: 4 mL Injection of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation With Right Atrial Enlargement
Status: COMPLETED
Conditions: Persistent Atrial Fibrillation|Right Atrial Enlargement
Interventions: PROCEDURE: Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation|PROCEDURE: Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Tamsulosin vs Prazosin in Treatment of Female Voiding Dysfunction
Status: UNKNOWN
Conditions: Neurogenic Bladder
Interventions: DRUG: tamsolusin|DRUG: prazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of ADR-001 in Patients With Severe Pneumonia Caused by SARS-CoV-2 Infection
Status: COMPLETED
Conditions: Severe Acute Respiratory Syndrome Coronavirus 2
Interventions: BIOLOGICAL: Mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Single Agent Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Ovarian or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Peritoneal Cancer
Interventions: DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Teriparatide or Zoledronic Acid Treatment on Bone in Postmenopausal Osteoporotic Women
Status: COMPLETED
Conditions: Osteoporosis, Post-menopausal
Interventions: DRUG: Teriparatide|DRUG: Zoledronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Estramustine and Oral Vinorelbine in the Treatment of Hormone-Refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Estramustine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interrater Variability for the Identification of Anesthetic-induced Burst Suppression EEG
Status: UNKNOWN
Conditions: Burst Suppression|General Anesthesia|Electroencephalogram
Interventions: OTHER: MATLAB-based interface, showing 50 EEG traces, classification of the EEG-pattern as Burst Suppression possible, yes, no.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC