pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Morphological Abnormalities of the Olfactory Bulb on MRI and Olfactometry in Anosmic Versus Normosmic COVID-19 Patients
Status: COMPLETED
Conditions: Olfaction Disorders|COVID-19
Interventions: DIAGNOSTIC_TEST: ENT exam|DIAGNOSTIC_TEST: Olfactometry|DIAGNOSTIC_TEST: Brain MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Efficacy, Safety, PK, and Immunogenicity Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoporosis, Postmenopausal
Interventions: BIOLOGICAL: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Active Smart Wearable Orthosis for Enhanched Rehabilitation THErapy
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Test upper limb robot assisted therapy device|DEVICE: Training with new upper limb robot assisted therapy device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Treatment Option for Demodicosis in Patients Undergoing Cataract Surgery
Status: COMPLETED
Conditions: Demodex Infestation|Demodicosis|Cataract
Interventions: OTHER: Tea Tree Oil Shampoo|DRUG: Ciprofloxacin Ophthalmic Ointment 0.3%|OTHER: Baby shampoo|OTHER: Blephaclean
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Placebo-controlled Phase II Study of Bone-targeted Radium-223 in Symptomatic Hormone-refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Neoplasm Metastasis
Interventions: DRUG: Radium-223 dichloride (BAY88-8223)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Testosterone for Fatigue in Male Multiple Sclerosis Patients
Status: TERMINATED
Conditions: Multiple Sclerosis|Fatigue
Interventions: DRUG: Testosterone undecanoate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel for the Treatment of Distal Radial Artery Arteriovenous Access Fistula Stenosis (PaciFIST-2)
Status: WITHDRAWN
Conditions: Arteriovenous Access Fistula Stenosis
Interventions: DRUG: Paclitaxel|PROCEDURE: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intermittent Fasting and Exercise: Effects on Gut Microbiota, Body Composition and Inflammation.
Status: COMPLETED
Conditions: Composition and Function of the Gut Microbiota Post Intervention|Metabolic and Inflammatory Variables Post Intervention
Interventions: OTHER: Intervention with intermittent fasting.|OTHER: Intervention with high-intensity interval training.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment Predictors Reflecting Beta-catenin Activation in Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: COMBINATION_PRODUCT: Fluorine-18 fluorocholine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pain Relieving Efficacy of TAP Block in Patients After Laparoscopic Gastric Bypass.
Status: COMPLETED
Conditions: Pain|Obesity|Surgery|Neuromuscular Inhibition
Interventions: DRUG: Placebo: sterile normal saline|DRUG: Marcaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dietary Management of Gestational Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes, Gestational|Dietary Modification|Glucose Intolerance During Pregnancy|Body Composition|Birth Weight
Interventions: OTHER: Carbohydrate restricted diet|OTHER: Plant-protein based diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Three Regimens of Chemoprophylaxis for Tuberculosis in Patients co-Infected by HIV and Mycobacterium Tuberculosis
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: isoniazid, rifampin + isoniazid or rifampin + pyrazinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Diode Laser in Peri-implantitis
Status: COMPLETED
Conditions: Implant|Peri-Implantitis|Alveolar Bone Loss|Complications
Interventions: PROCEDURE: Conventional peri-implantitis treatment|DEVICE: DL application in peri-implantitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy Study of MTS-01 for the Prevention of Alopecia Induced by WHole Brain Radiotherapy
Status: TERMINATED
Conditions: Alopecia
Interventions: DRUG: MTS-01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry "Bad Cholesterol" in the Blood
Status: COMPLETED
Conditions: Type 2 Diabetes|Insulin Sensitivity/Resistance|Inflammatory Response|Fatty Acids, Omega-3
Interventions: DIETARY_SUPPLEMENT: Omega-3 fatty acids (2.7 g/d, EPA:DHA, 2:1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Whole Breast Radiotherapy (RT) With Intensity Modulated Radiotherapy (IMRT) and a Simultaneous Integrated Boost Versus Conventional RT and a Sequential Boost
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: IMRT with an simultaneous integrated boost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Function Intervention Trial in Sickle Cell Disease
Status: UNKNOWN
Conditions: Sickle Cell Disease
Interventions: DIETARY_SUPPLEMENT: Vascular ready-to-use supplementary food|DIETARY_SUPPLEMENT: Regular Ready-to-use supplementary food|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan.
Status: COMPLETED
Conditions: Hyperaldosteronism
Interventions: OTHER: Ct-scan or adrenal vein sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bupivacaine 5 mg vs 7.5 mg for Spinal Anesthesia in Cesarean Delivery in Indonesian Population
Status: COMPLETED
Conditions: Cesarean Section|Hypotension Drug-Induced|Spinal Anesthesia|Postoperative Complications
Interventions: DRUG: Bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Resveratrol for Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Resveratrol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Combinations in Metastatic Breast Cancer (MBC), 1st Line
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: gemcitabine|DRUG: paclitaxel|DRUG: carboplatin|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TD-1473 Long-Term Safety (LTS) Ulcerative Colitis (UC) Study
Status: TERMINATED
Conditions: Ulcerative Colitis (UC)
Interventions: DRUG: TD-1473 Dose A|DRUG: TD-1473 Dose B|DRUG: TD-1473 Dose C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Function Improvement in HBsAg Positive Kidney Transplantation Patients Under Telbivudine Treatment.
Status: TERMINATED
Conditions: HBsAg-positive Renal Allograft Recipients
Interventions: DRUG: Telbivudine|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture and Solifenacin for Urgency-predominant Mixed Urinary Incontinence
Status: UNKNOWN
Conditions: Mixed Urinary Incontinence|Urgency-predominant Mixed Urinary Incontinence
Interventions: DEVICE: electroacupuncture|DEVICE: sham electroacupuncture|DRUG: Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induction of Labor in Morbidly Obese Patients
Status: RECRUITING
Conditions: Morbid Obesity|Pregnancy
Interventions: DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Intermittent Fasting and Insulin Resistance
Status: UNKNOWN
Conditions: Diabetes Mellitus|Non-alcoholic Fatty Liver Disease|Metabolic Syndrome|Obesity
Interventions: BEHAVIORAL: Intermittent fasting|OTHER: Time control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Consolidative Radiotherapy for Metastatic Urothelial Bladder Cancer Patients Without Progression and With no More Than Three Residual Metastatic Lesions Following First Line Systemic Therapy
Status: RECRUITING
Conditions: Urothelial Bladder Cancer
Interventions: RADIATION: Experimental arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluate the Immunogenicity and Safety of Recombinant COVID-19 Omicron-Delta Variant Vaccine (CHO Cell)
Status: RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Omicron-Delta Recombinant Novel Coronavirus Protein Vaccine (CHO cells)|BIOLOGICAL: Recombinant Novel Coronavirus Protein Vaccine (CHO cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Primary Prevention of Atopic Disease by Perinatal Administration of Probiotics
Status: COMPLETED
Conditions: Food Allergy|Atopic Dermatitis|Asthma|Rhinitis
Interventions: DIETARY_SUPPLEMENT: Probiotic bacteria|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Smartphone Parent-child Partner Exercises Application Study
Status: COMPLETED
Conditions: Physical Activity
Interventions: BEHAVIORAL: Family Move app intervention|BEHAVIORAL: "HK FitNuts" app intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Atlas Cedarwood Essential Oil Aromatherapy on Sleep Quality Among Patients With Coronary Heart Disease
Status: COMPLETED
Conditions: Sleep Quality|Coronary Heart Disease
Interventions: OTHER: Organic Atlas cedar wood essential oil (Cedrus Atantica)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Pain With Radiesse® With Lidocaine for Nasolabial Folds
Status: COMPLETED
Conditions: Nasolabial Folds
Interventions: DEVICE: Radiesse® Injectable Dermal Filler with Lidocaine|DEVICE: Radiesse® Injectable Dermal Filler without Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?
Status: COMPLETED
Conditions: Stress, Psychological|Inflammation|Cortisol|Sympathetic Nervous System
Interventions: DRUG: Propanolol hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair
Status: RECRUITING
Conditions: Esophageal Atresia|Tracheoesophageal Fistula
Interventions: DEVICE: Transanastomotic Tube (5FR)|OTHER: No Transanastomotic Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: BEHAVIORAL: Active Retraining|BEHAVIORAL: Sham Retraining|DEVICE: Active transcranial direct current stimulation (TDCS)|DEVICE: Sham transcranial direct current stimulation (TDCS)|DRUG: Nicotine Replacement Therapy (Habitrol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Methods for Assisting Needle Angle Selection During Image-guided Tissue Biopsy
Status: COMPLETED
Conditions: Lung Neoplasms|Liver Neoplasms|Kidney Neoplasms|Cancer
Interventions: DEVICE: Needle angle measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Tapentadol 100 MG Oral Tablet|DRUG: Pregabalin 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stories for Change: Digital Storytelling for Diabetes Self-Management Among Somali Adults
Status: COMPLETED
Conditions: Type2 Diabetes
Interventions: BEHAVIORAL: Digital Storytelling Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
Status: RECRUITING
Conditions: TIA|Carotid Artery Plaque|Carotid Atherosclerosis
Interventions: DRUG: Interleukin-2 [IL-2]|PROCEDURE: Standard care - Carotid Endarterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Commensal Oral Microbiota in Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer|Oral Mucositis
Interventions: OTHER: Standard of Care Oral Hygiene|PROCEDURE: Oral mucosal deterging and dental prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4 Week 2 Way Crossover Double Blind Treatment Phase With Combivent CFC Versus Albuterol Followed by a 4 Week Open Label Combivent Respimat When All Drugs Are Used for Symptom Relief as Needed in Pts With Moderate to Severe Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Combivent CFC MDI|DRUG: Albuterol HFA MDI|DRUG: Respimat Combivent
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: Assessment of Cognitive Function Before and After Conversion From Immediate Release Tacrolimus to Envarsus XR.
Status: COMPLETED
Conditions: Kidney Transplant; Complications
Interventions: DRUG: Tacrolimus, Extended Release, (Envarsus Xr)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Placebo|DRUG: Denosumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of V116 in Pneumococcal Vaccine-naïve Adults 50 Years of Age or Older (V116-010, STRIDE-10)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pneumococcal Disease
Interventions: BIOLOGICAL: V116|BIOLOGICAL: PPSV23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Maxillary Sinus Lift With and Without Self-hardening Biphasic Calcium Phosphate.
Status: COMPLETED
Conditions: Maxillary Sinus Augmentation
Interventions: OTHER: Moldable self-hardening biphasic calcium phosphate graft|PROCEDURE: No graft material placed - Blood Clot only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone Treatment of Women With Turner Syndrome
Status: COMPLETED
Conditions: Turner Syndrome
Interventions: DRUG: Growth Hormone|DRUG: Placebo|OTHER: Healthy controls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-durg Interaction of Leritrelvir(RAY1216) With Midazolam, Omeprazole, Rosuvastatin, Verapamil, and Rifampin
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Midazolam|DRUG: Omeprazole|DRUG: Rosuvastatin|DRUG: Verapamil|DRUG: Rifampin|DRUG: Leritrelvir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ciclosporin Versus Alitretinoin for Severe Atopic Hand Dermatitis.
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: Ciclosporin|DRUG: Alitretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tablet-Aided BehavioraL Intervention EffecT on Self-management Skills
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus, Adult-Onset|Diabetes Mellitus, Non-Insulin-Dependent|Diabetes Mellitus, Noninsulin Dependent|Diabetes Mellitus, Type II
Interventions: BEHAVIORAL: Tablets Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Group-based [ADAPT] Versus One-to-one [Usual] Occupational Therapy (Go:OT Trial)
Status: RECRUITING
Conditions: Chronic Condition|Chronic Disease|Chronic Conditions, Multiple
Interventions: BEHAVIORAL: The ADAPT Program|BEHAVIORAL: UOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Endotoxin, Escherichia Coli|PROCEDURE: Magnetic Resonance Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cranberry Juice for Treatment of Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Cranberry juice|DIETARY_SUPPLEMENT: Placebo cranberry juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy of Transmuscular Quadratus Lumborum in Patients Undergoing Total Abdominal Hysterectomy
Status: COMPLETED
Conditions: Pain Postoperative
Interventions: PROCEDURE: Transmuscular quadratus lumborum block|DRUG: morphine|DRUG: ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction
Status: RECRUITING
Conditions: Acute Myocardial Infarction|Non-ST Elevation Myocardial Infarction (nSTEMI)|ST Elevation Myocardial Infarction
Interventions: DRUG: Metoprolol Succinate|DRUG: Bisoprolol|DRUG: Carvedilol|DRUG: Nebivolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Hyaluronic Acid for Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Sono-guided injection with hyaluronic acid|PROCEDURE: Sono-guided injection with normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Evaluating The Effects Of Pyrotinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Hydromorphone Hydrochloride 8 mg Tablets and Dilaudid 8 mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Hydromorphone Hydrochloride tablet 8 mg|DRUG: Dilaudid® tablet 8 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Adriamycin and Ifosfamide Combined With Sintilimab
Status: RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: Sintilimab plus chemotherapy|DRUG: Adriamycin-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is it Necessary to Fix Mesh in Laparoscopic Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia|Pain, Acute|Pain, Chronic
Interventions: DEVICE: Tacker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Influence of Enteral Microbiome on Mortality of Patients With Cardiogenic Shock
Status: RECRUITING
Conditions: Cardiogenic Shock|Microbial Colonization|Out-Of-Hospital Cardiac Arrest|Acute Heart Failure|Acute Myocardial Infarction
Interventions: OTHER: Observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plerixafor and Clofarabine in Frontline Treatment of Elderly Patients With Acute Myelogenous Leukemia (AML)
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Plerixafor|DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate The Effectiveness Of Fospropofol (Lusedra®) For Induction Of Anesthesia
Status: WITHDRAWN
Conditions: Interstitial Cystitis
Interventions: DRUG: Fospropofol (Lusedra®) 6.5|DRUG: Fospropofol (Lusedra®) 10|DRUG: Fospropofol (Lusedra®) 12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness of Acetylsalicylic Acid on Markers of Vascular Dysfunction in Scleroderma Patients
Status: COMPLETED
Conditions: Systemic Sclerosis
Interventions: DRUG: Acetylsalicylic acid|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin- 17 (IL-17), Bcl-3, and NF-kappa-B Inhibitor Zeta (IκBζ) Expression Levels in the Psoriasis Patients
Status: COMPLETED
Conditions: Psoriasis|Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: Gingival crevicular fluid collection|DIAGNOSTIC_TEST: periodontal test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies
Status: COMPLETED
Conditions: Stage III Cutaneous Melanoma|Stage IV Cutaneous Melanoma|Locally Advanced Melanoma|Locally Advanced Solid Neoplasm|Metastatic Head and Neck Squamous Cell Carcinoma|Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Metastatic Urothelial Carcinoma|Non-Small Cell Lung Carcinoma|Stage IB Lung Cancer AJCC v7|Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage III Lung Cancer AJCC v8|Stage III Ureter Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8|Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IV Ureter Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Abexinostat|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Assessment for Gastro-Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Cancer|Gastric Cancer|Barrett Esophagus
Interventions: DIAGNOSTIC_TEST: Breath analysis|DIAGNOSTIC_TEST: Blood analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the PK Similarity of AK104 in Healthy Chinese Male Subjects
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: AK104 (before the change)|DRUG: AK104 (after the change)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Using MIST With or Without EMD in Treatment of Intrabony Periodontal Defects.
Status: UNKNOWN
Conditions: Intrabony Periodontal Defects
Interventions: PROCEDURE: Minimally Invasive Surgical Techniques (MIST)|PROCEDURE: Enamel Matrix Derivative (EMD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Immunogenicity of a Single Dose of GlaxoSmithKline's (GSK) Meningococcal MenACWY-CRM Vaccine (Menveo), Administered to Subjects 15 Through 55 Years of Age, Approximately 4-6 Years After Primary ACWY Vaccination
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal (groups A, C, W and Y) oligosaccharide diphtheria CRM-197 conjugate Vaccine (Menveo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Efficacy and Safety/Tolerability of Subcutaneous Tildrakizumab (SCH 900222/MK-3222) in Participants With Moderate-to-Severe Chronic Plaque Psoriasis Followed by a Long-term Extension Study (MK-3222-011)
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Tildrakizumab 200 mg|DRUG: Tildrakizumab 100 mg|DRUG: Tildrakizumab Placebo|DRUG: Etanercept Placebo|DRUG: Etanercept 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Androgen Deprivation Therapy (ADT) Versus ADT Plus Prostate Cryotherapy for Metastatic Prostate Cancer (mPCa)
Status: RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DEVICE: prostate cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning
Status: COMPLETED
Conditions: Organophosphate Poisoning
Interventions: DRUG: Rocuronium|DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tebipenem (SPR994) Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
Status: COMPLETED
Conditions: Diabetes|Wound Infection|ABSSSI|Healthy Volunteers
Interventions: DRUG: Tebipenem Pivoxil Hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Erector Spinae Block, Epidural Analgesia and Intrathecal Analgesia in Thoracic Surgery
Status: UNKNOWN
Conditions: Pulmonary Surgery
Interventions: PROCEDURE: Epidural anesthesia|PROCEDURE: Intrathecal morphine|PROCEDURE: Erector spinae block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Gastric Cancer|Gastroesophageal Junction Cancer
Interventions: DRUG: AZD7789
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Aprepitant in BEP Treatment of Patients With Testis Carcinoma (A-BEP)
Status: WITHDRAWN
Conditions: Nausea|Vomiting
Interventions: DRUG: Aprepitant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: Ulixertinib|DRUG: Encorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 Diabetics
Status: COMPLETED
Conditions: Insulin Secretion|Insulin Resistance
Interventions: DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Handover of Anesthesia Care on Adverse Postoperative Outcomes
Status: COMPLETED
Conditions: Anesthesia|Adverse Effect of Handovers of Anesthesia Care
Interventions: PROCEDURE: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT
Status: RECRUITING
Conditions: Post Operative Surgical Site Infection
Interventions: DRUG: Standard of care|DRUG: Vancomycin and Tobramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mental Health Care in People With Cancer
Status: RECRUITING
Conditions: Breast Cancer|Colorectal Cancer|Lung Cancer|Prostate Cancer
Interventions: OTHER: Questionnaires|OTHER: Interviews|OTHER: 30-minute telephone or videoconference sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Arm Motor Rehabilitation, Entertainment and Cognition System for the Elderly (Clinical Trial)
Status: COMPLETED
Conditions: Acute Stroke
Interventions: DEVICE: Rehabilitation Therapy on Experimental Robotic Table and standard of care|GENETIC: Rehabilitation Therapy as part of Standard of Care (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Biopsychosocial Effect of Service Dog Training on Post-traumatic Stress (PTS) and Post Concussive Symptoms
Status: UNKNOWN
Conditions: Post-traumatic Stress Disorder|Posttraumatic Stress Disorder|Traumatic Brain Injury
Interventions: OTHER: Service Dog Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Neoplasms|Adverse Drug Event
Interventions: DIETARY_SUPPLEMENT: Nutritional Support Team|DRUG: Docetaxel|DRUG: cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Melphalan+Prednisolon With or Without Thalidomide in Previously Untreated Elderly Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Thalidomide|DRUG: Melphalan+Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: YM150|DRUG: Placebo|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models
Status: RECRUITING
Conditions: Oxidative Injury|Stress Physiological|Discogenic Pain|Cardiovascular Risk Factor|Space Maintenance|Epigenetic Changes|LONGEVITY 1|Neuroplasticity|NGS
Interventions: OTHER: Biological sample collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Central Mechanisms of Chronic Pain and Fatigue Subtitle: Functional Imaging of Brain and Spinal Cord
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Fatigue Syndrome|Fibromyalgia
Interventions: DEVICE: A Peltier for Sensory testing|DEVICE: functional magnetic resonance imaging for Brain Neuroimaging|DEVICE: fMRI for Spinal Cord Neuroimaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Remifentanil for the I-gel and Laryngeal Mask Airway Insertion
Status: COMPLETED
Conditions: Supraglottic Airways for General Anesthesia
Interventions: DRUG: remifentanil|DEVICE: i-gel|DEVICE: laryngeal mask airway|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Two Epoetin Alfa Dosing Strategies in Subjects With Chronic Kidney Disease Receiving Hemodialysis
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Anemia|Renal Dialysis|Erythrocyte Transfusion
Interventions: DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Aleglitazar in Combination With Oral Contraceptive Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Aleglitazar|DRUG: Microgynon®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Prospective Randomized Trial Comparing Endoscopic Submucosal Dissection Against Laparoscopic Assisted Gastrectomy for Treatment of Early Gastric Cancer
Status: COMPLETED
Conditions: Early Gastric Cancer
Interventions: PROCEDURE: Endoscopic Submucosal Dissection|PROCEDURE: Laparoscopic assisted Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure
Status: COMPLETED
Conditions: Glaucoma, Angle-closure
Interventions: PROCEDURE: Paracentesis|DRUG: Acetazolamide|PROCEDURE: Peripheral iridotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Psoriasis Patients' Adherence to Topical Drugs
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: OTHER: Improved support by health-care professionals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) and Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: BIOLOGICAL: Sacituzumab tirumotecan|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Antihistamine|DRUG: H2 Receptor Antagonist|DRUG: Acetaminophen (or equivalent)|DRUG: Dexamethasone (or equivalent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contribution of L-Tyrosine to Human Decision Making in Stressful Situations
Status: COMPLETED
Conditions: Stress, Psychological
Interventions: BIOLOGICAL: Blood collection|DRUG: L-Tyrosine 500 Mg|DRUG: Placebo|BEHAVIORAL: Cognitive tasks|OTHER: Stress exposure|BEHAVIORAL: Anxiety scale|DEVICE: Electromyography (EMG)|DEVICE: Electroencephalography (EEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project
Status: ENROLLING_BY_INVITATION
Conditions: Coronary Artery Disease|Atrial Fibrillation|Heart Failure|Valvular Heart Disease
Interventions: DIAGNOSTIC_TEST: Early diagnosis strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of GlideScope-Specific Rigid Stylet to Standard Malleable Stylet for GlideScope Intubation by Novice Operators
Status: COMPLETED
Conditions: Airway
Interventions: DEVICE: GlideScope rigid stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effectivity of Bilateral Transversus Thoracis Muscle Plane Block After Open Heart Surgery
Status: COMPLETED
Conditions: Interleukin-6|Cortisol
Interventions: PROCEDURE: Bilateral transversus thoracis muscle plane block|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DRUG: AMG 510|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Study Efficacy and Safety of Two Dosing Regimens of MN-001 in Patients With Interstitial Cystitis
Status: COMPLETED
Conditions: Interstitial Cystitis
Interventions: DRUG: MN-001 BID|DRUG: MN-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interview in Adolescents With Poorly Controlled Type 1 Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Standard Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Syncardia 50cc TAH-t as a Bridge to Transplant
Status: TERMINATED
Conditions: Heart Failure, Right-Sided|Cardiac Failure|Heart Failure, Left-Sided
Interventions: DEVICE: SynCardia 50cc temporary Total Artificial Heart (TAH-t)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Transplantation for Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Imatinib Mesylate|PROCEDURE: Autologous Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Best Treatment Strategy: Surgical vs Pharmacological to Close the Ductus Arteriosus Persistent in Preterm Infants
Status: UNKNOWN
Conditions: Persistent Ductus Arteriosus
Interventions: PROCEDURE: Surgical treatment|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proficiency-Based Progression Training for Clinical Communication
Status: COMPLETED
Conditions: Clinical Communication|ISBAR|Simulation|Proficiency-Based Progression|Non Technical Skills|Performance|Deteriorating Patient
Interventions: BEHAVIORAL: Proficiency-based progression|BEHAVIORAL: National e-learning programme only|BEHAVIORAL: Standard simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Trial of Allogeneic Stem Cell Transplants From HLA Compatible, Related and Unrelated Donors After a Myeloablative Preparative Regimen With Hyperfractionated TBI, Thiotepa and Fludarabine For Adult Patients With Lymphohematopoietic Disorders
Status: COMPLETED
Conditions: Allogeneic Stem Cell Transplant|Leukemia|Non-Hodgkins|Lymphoblastic Lymphoma|Myelodysplastic Syndrome|Paroxysmal Nocturnal Hemoglobinuria (PNH)
Interventions: DRUG: cytoreductive regimen followed by a CD34+E- selected allogeneic stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Pazopanib With GSK1120212 in Advanced Solid Tumors, Enriched With Patients With Differentiated Thyroid Cancer, Soft-tissue Sarcoma, and Cholangiocarcinoma
Status: COMPLETED
Conditions: Solid Tumors|Thyroid Cancer|Soft-tissue Sarcoma|Cholangiocarcinoma
Interventions: DRUG: Pazopanib|DRUG: GSK1120212
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Paclitaxel + Carboplatin With/Out Cediranib Maleate in Stage III or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: cediranib maleate|DRUG: paclitaxel|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Kinesiotaping on Wrist Kinematics and Functional Performance
Status: COMPLETED
Conditions: Wrist Injuries|Kinematics|Functional Performance
Interventions: OTHER: Kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging in MGUS, SMM and MM
Status: COMPLETED
Conditions: Multiple Myeloma|Smoldering Multiple Myeloma|Monoclonal Gammopathy of Undetermined Significance
Interventions: DRUG: 18-NaF PET|OTHER: DCE-MRI|DRUG: 18-FDG PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Decreasing Hemorrhage Risk in Children With Alagille Syndrome
Status: ENROLLING_BY_INVITATION
Conditions: Alagille Syndrome|Pulmonary Artery Stenoses|Acquired Von Willebrand Disease
Interventions: OTHER: Assessment for bleeding disorder with tailored post-operative care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immediate Implant Using Socket Shield Technique With Xenogenic Bone Graft
Status: UNKNOWN
Conditions: Immediate Implant
Interventions: BIOLOGICAL: deproteinized bovine bone mineral (DBBM) by OneXeno Graft. ( OneGraft, Germany)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT