pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combination Therapy With Differin® Gel 0.3% and Duac® (Clindamycin/Benzoyl Peroxide Gel) in Subjects With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: adapalene gel, 0.3%|DRUG: clindamycin/benzoyl peroxide gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Evaluation for Fu's Subcutaneous Needling (FSN) in Carpal Tunnel Syndrome.
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: wrist splinting|DEVICE: FSN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Allium Cepa in the Management of Shoulder Pain Post Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: BIOLOGICAL: Topical App. of Allium Cepa Extract|BIOLOGICAL: Phonophoresis of Allium Cepa Extract|BIOLOGICAL: Raw Mashed Allium Cepa Application|OTHER: Standard Physiotherapy Group (SPG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pathology, Venous Disease, and Clinical Correlations
Status: UNKNOWN
Conditions: Varicose Veins|Pathology|Symptoms and Signs
Interventions: PROCEDURE: Stab Avulsion of varicose veins|DIAGNOSTIC_TEST: Histopathologic evaluation of varicose veins
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Traditional Three Incisions vs Minimally Invasive Thoracol-laparoscopic Esophagectomy for Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Carcinoma
Interventions: PROCEDURE: MIE|PROCEDURE: OE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Resection of Adenoma and Colic Adenocarcinoma by EMR Piecemeal or EMR/ESD Hybrid Technique
Status: UNKNOWN
Conditions: Colorectal Adenoma|Intramucinous Adenocarcinoma
Interventions: PROCEDURE: Endoscopic resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Skills Training to Enhance Vocational Outcomes in Veterans With Serious Mental Illness
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder|Psychotic Disorders
Interventions: BEHAVIORAL: Social Cognition and Intervention Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of 0.1% and 0.2% Sodium Hyaluronate on Postoperative Discomfort Following Phacoemulsification Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Sodium Hyaluronate 0.1% drops|DRUG: Sodium Hyaluronate 0.2% drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Compare Outcomes After High and Low Ligation of Inferior Mesenteric Artery in Colorectal Cancer
Status: RECRUITING
Conditions: Colon Cancer
Interventions: PROCEDURE: ligation of inferior mesenteric artery in colorectal cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Apnea Screening
Status: TERMINATED
Conditions: Sleep Apnea/Hypopnea Syndrome
Interventions: OTHER: Berlin and Epworth questionaries|OTHER: Sleep apnea monitoring in those patients in whom a pacemaker with monitoring apnea system has been implanted.|OTHER: Night polygraph / Polysomnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: Treatment 1. (5% Hypertonic saline + Epinephrine)|DRUG: Treatment 3. (3% Hypertonic saline + Epinephrine)|DRUG: Treatment 2. (Normal saline + Epinephrine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Extension Study of Daclizumab High Yield Process (DAC HYP) (BIIB019) in Participants Who Have Completed Study 205MS202 (NCT00870740) to Treat Relapsing Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: BIOLOGICAL: BIIB019 (Daclizumab)|BIOLOGICAL: trivalent seasonal influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety and Immune Response of Stage IIB-IV Resected Melanoma After Treatment With MAGE-A3 ASCI
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: recMAGE-A3 + AS15 ASCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fasting on the Non-invasive Measurement of the Body's Water Compartments
Status: COMPLETED
Conditions: Dehydration|Perioperative Complication
Interventions: DIETARY_SUPPLEMENT: Nutricia Pre-op, 400 milliliters, per os
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A 14-week Pilot Prospective Clinical Trial With BiOkuris Product in Patients With Irritable Bowel Syndrome
Status: RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: DDI-IBS-001|OTHER: DDDI-IBS-001 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clinical Validation of Cervical Cancer Screening Methods
Status: UNKNOWN
Conditions: Cervical Cancer|Cervical Dysplasia|Human Papilloma Virus
Interventions: DIAGNOSTIC_TEST: Papanicolaou cytological test|DIAGNOSTIC_TEST: Local cytological test (H&E stain)|DIAGNOSTIC_TEST: Validated HPV DNA Test|DIAGNOSTIC_TEST: Local HPV test|DIAGNOSTIC_TEST: Colposcopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sequential Natalizumab - Alemtuzumab Therapy in Patients With Relapsing Forms of Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis (MS)
Interventions: DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SPI-guided Analgesia During CEA Under RA
Status: UNKNOWN
Conditions: Carotid Artery Stenoses
Interventions: DRUG: infiltration rescue intraoperative analgesia|DRUG: rescue IA|DRUG: rescue antyhypertensive medication|DRUG: rescue antyemetic medication|DRUG: rescue antyhypotensive medication|DRUG: rescue antyhypotensive medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Market Research - Acceptability Study for a Range of MCT Products
Status: COMPLETED
Conditions: Ketosis|Epilepsy|Ketogenic Diet|Fatty Acid Oxidation Disorder|Malabsorption
Interventions: DIETARY_SUPPLEMENT: MCT fats
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ifetroban in Treating Patients With Malignant Solid Tumors at High Risk of Metastatic Recurrence
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Solid Tumor
Interventions: DRUG: Ifetroban Sodium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KAZ954 Alone and With PDR001, NZV930 and NIR178 in Advanced Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors
Interventions: DRUG: KAZ954|DRUG: PDR001|DRUG: NIR178|DRUG: NZV930
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manual Therapy/Exercises vs. Physiotherapy/Back School vs. Waiting List in Patients With Chronic Low Back Pain
Status: TERMINATED
Conditions: Chronic Low-back Pain
Interventions: BEHAVIORAL: Manual Therapy/Exercises|BEHAVIORAL: Physiotherapy/Back School
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy to Reduce Anxiety in Community-Dwelling Individuals With Severe Mental Illness
Status: COMPLETED
Conditions: Severe Mental Disorder|Schizophrenia|Bipolar Disorder|Anxiety
Interventions: OTHER: Music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Olokizumab 64 mg SC q4w|DRUG: Olokizumab 64 mg SC q2w|DRUG: Concomitant treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Efficacy, and Pharmacokinetic (PK) Study of HBI-002, an Oral Carbon Monoxide (CO) Therapeutic, in Subjects With Sickle Cell Disease (SCD)
Status: NOT_YET_RECRUITING
Conditions: Anemia, Sickle Cell
Interventions: DRUG: HBI-002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooled RFA vs Conventional RFA to Manage Chronic Facetogenic Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low-back Pain
Interventions: DEVICE: Cooled Radiofrequency|DEVICE: Conventional Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A BE Study to Compare Beclomethasone Dipropionate Inhalation Aerosol, 40 mcg and QVAR® 40 mcg, Inhalation Aerosol
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Test Product|DRUG: Reference Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of the GILL eHealth Intervention to Improve Physical Health and Lifestyle Behaviours in Patients With Severe Mental Illness
Status: RECRUITING
Conditions: Severe Mental Disorder|Metabolic Syndrome|Lifestyle|Somatic Screening|eHealth
Interventions: DEVICE: GILL eHealth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded Cross-over Study
Status: TERMINATED
Conditions: Rectal Cancer|Ulcerative Colitis|Short Bowel Syndrome
Interventions: DRUG: Loperamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Nexvax2 in Subjects With Coeliac Disease
Status: COMPLETED
Conditions: Coeliac Disease|Celiac Disease
Interventions: BIOLOGICAL: 9 micrograms Nexvax2|BIOLOGICAL: 30 micrograms Nexvax2|BIOLOGICAL: 90 micrograms Nexvax2|BIOLOGICAL: 60 micrograms Nexvax2|BIOLOGICAL: Up to 900 micrograms Nexvax2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Versus Bolus Administration of Norepinephrine to Treat Hypotension During Anesthetic Induction
Status: RECRUITING
Conditions: Intraoperative Hypotension
Interventions: PROCEDURE: Continuous norepinephrine administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adults With Hyperhomocysteinemia
Status: UNKNOWN
Conditions: Hyperhomocysteinemia
Interventions: DIETARY_SUPPLEMENT: supplementation of compound nutrients|DIETARY_SUPPLEMENT: placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients With Severe Acute Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Acute Brain Injury
Interventions: OTHER: Hyperglycaemic clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Renal Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Renal Function
Status: COMPLETED
Conditions: Healthy Volunteers|Renal Impairment
Interventions: DRUG: fezolinetant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ig NextGen 10% in Idiopathic Thrombocytopenic Purpura (ITP) Patients
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura (ITP)
Interventions: DRUG: IgNextGen 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Probiotic Supplementation in Psoriasis Vulgaris
Status: UNKNOWN
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Lactobacillus Plantarum IS-10506|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of Postpartum Immunization of Rh and Coombs Negative Women With Sensitization Risk.
Status: SUSPENDED
Conditions: Pregnancy; Fetomaternal Hemorrhage
Interventions: BIOLOGICAL: Immunoglobulin Anti-RhD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for Tonsillectomy Pain
Status: COMPLETED
Conditions: Children|Postoperative Pain|Tonsillar Hypertrophy|Obstructive Sleep Apnea|Chronic Tonsillitis
Interventions: OTHER: Acupuncture|OTHER: Sham Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: Guselkumab Dose 1|DRUG: Guselkumab Dose 2|DRUG: Guselkumab Dose 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Diosmin|DRUG: Cabergoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Feasibility of the Infinity Catheter for Radial Access
Status: COMPLETED
Conditions: Brain Tumor|Stroke, Acute|Brain Aneurysm|Intracranial Arteriovenous Malformations|Carotid Stenosis|Cavernous Sinus Thrombosis
Interventions: DEVICE: Transradial approach
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodal Drug Infiltration in Total Knee Arthroplasty: Is Posterior Capsular Infiltration Worth the Risk?
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: 0.5% bupivacaine 100 mg, morphine sulfate 5 mg, 0.1% epinephrine 0.6 mg, and ketorolac 30 mg mixed NSS up to 100 mL|PROCEDURE: Drug injection at Anterior soft tissue (25 mL)+Medial gutter area (25 mL)+Lateral gutter area (25 mL)+Posterior capsular infiltration (25 mL)|PROCEDURE: Drug injection at Anterior soft tissue (34 mL)+Medial gutter area (33 mL)+Lateral gutter area (33 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Interactive Educational Website for Improving the Quality of Mental Health Care for People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Interactive Website on management of schizophrenia|BEHAVIORAL: Written materials and video on management of schizophrenia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Substance Abuse Pre-Treatment Screening Study
Status: RECRUITING
Conditions: Cocaine Abuse|Cocaine Dependence|Opiate Dependence|Alcohol Dependence|Substance Abuse
Interventions: DRUG: modafinil|DRUG: d-amphetamine|DRUG: L-Dopa|DRUG: Naltrexone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Tolerance and Pharmacokinetics of Suramin Sodium
Status: UNKNOWN
Conditions: Hand, Foot and Mouth Disease
Interventions: DRUG: suramin sodium|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775/E7080-G000-309 Per Merck Standard Convention [KEYNOTE-775])
Status: ACTIVE_NOT_RECRUITING
Conditions: Endometrial Neoplasms
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib|DRUG: Paclitaxel|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluoxetine vs Aripiprazole Comparative Trial (FACT)
Status: TERMINATED
Conditions: Attenuated Psychosis Syndrome
Interventions: DRUG: Aripiprazole|DRUG: Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery
Status: UNKNOWN
Conditions: Infratentorial Neoplasms
Interventions: DEVICE: SctO2|DEVICE: BIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AV-101 (L-4-chlorokynurenine) in Parkinson's Disease Subjects With Levodopa-Induced Dyskinesia
Status: UNKNOWN
Conditions: Parkinson Disease|Dyskinesia, Medication-Induced|L-Dopa Causing Adverse Effects in Therapeutic Use
Interventions: DRUG: AV-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients
Status: TERMINATED
Conditions: Surgical Site Infection
Interventions: DRUG: Chlorhexidine Gluconate 2% Wipe|OTHER: Theraworx Bath Wipes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mic-Key Versus Mini One Family Preference Comparison
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Feeding Disorder|Family Satisfaction
Interventions: OTHER: GT button change - Mic-Key|OTHER: GT button change - Mini One
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Chlorhexidine Scrub, ZnO Nanoparticles Socks and the Combination for Prevention of Pitted Keratolysis
Status: WITHDRAWN
Conditions: Foot Dermatoses
Interventions: DRUG: Chorhexidine scrub|DEVICE: ZnO-NPs socks|COMBINATION_PRODUCT: Combination of chorhexidine scrub and ZnO-NPs socks|DEVICE: Placebo socks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lateral Branch Cooled Radiofrequency Denervation vs. Conservative Therapy for Sacroiliac Joint Pain
Status: COMPLETED
Conditions: Sacroiliac Joint Pain
Interventions: DEVICE: SInergy Cooled Radiofrequency|OTHER: Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Understanding Brain Mechanisms Involved in Autobiographical Memory
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Alzheimer Disease|Memory Loss
Interventions: DEVICE: high-density electroencephalography (hdEEG)|DEVICE: Transcranial alternating current stimulation (tACS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized Trial of Vitamin D Supplementation With or Without Vitamin A in Stem Cell Transplantation
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplant
Interventions: DIETARY_SUPPLEMENT: Vitamin D and A|DIETARY_SUPPLEMENT: Vitamin D and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Treating Hepatolithiasis (Accompanied With SOL) With Choledochojejunostomy
Status: UNKNOWN
Conditions: Hepatolithiasis|Sphincter of Oddi Laxity
Interventions: PROCEDURE: Roux-en-Y choledochojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Cancer Effects of Carvedilol With Standard Treatment in Glioblastoma and Response of Peripheral Glioma Circulating Tumor Cells
Status: WITHDRAWN
Conditions: Glioblastoma|Glioblastoma Multiforme
Interventions: DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eltrombopag in Thrombocytopenic Chronic Lymphocytic Leukemia (CLL) Patients (CLL2S Study of GCLLSG)
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|Thrombocytopenia
Interventions: DRUG: Placebo|DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oltipraz for Liver Fat Reduction in Patients With Non-alcoholic Fatty Liver Disease Except for Liver Cirrhosis
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Oltipraz|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Probiotics and the Prevention of Traveler's Diarrhea
Status: TERMINATED
Conditions: Travelers' Diarrhea
Interventions: DIETARY_SUPPLEMENT: Protecflor|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Methylprednisolone on Immunological Function and Postoperative Pain
Status: COMPLETED
Conditions: Methylprednisolone|Immunological Function|Postoperative Pain
Interventions: DRUG: Methylprednisolone 1 mg•kg-1|DRUG: isotonic saline 1mg•kg-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Lactobacillus Rhamnosus GG Versus Placebo in Elderly Subjects Receiving Live Attenuated Influenza Vaccine
Status: COMPLETED
Conditions: Healthy|Influenza
Interventions: BIOLOGICAL: Lactobacillus rhamnosus GG ATCC 53103 (LGG)|BIOLOGICAL: Placebo|BIOLOGICAL: Live attenuated influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Cranberry (Poly)Phenol Consumption on Vascular Function
Status: COMPLETED
Conditions: Healthy Young
Interventions: DIETARY_SUPPLEMENT: cranberry (poly)phenol containing supplement|DIETARY_SUPPLEMENT: Placebo comparator: cranberry (poly)phenol deprived supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Knee Arthroplasty Activity Trial
Status: RECRUITING
Conditions: Knee Osteoarthritis|Total Knee Replacement
Interventions: BEHAVIORAL: Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives|BEHAVIORAL: Wrist based activity tracker wear|OTHER: Basic Study Activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis|Periodontal Pocket|Periodontal Attachment Loss|Periodontal Diseases
Interventions: BIOLOGICAL: autologous fibrin glue application as an adjunct to nonsurgical periodontal treatment of chronic periodontitis|OTHER: placebo application as an adjunct to nonsurgical periodontal treatment of chronic periodontitis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics and Safety of Antimicrobial Agents Administered by Subcutaneous Route in Patients AGEd Over 65 Years
Status: UNKNOWN
Conditions: Antimicrobials|Subcutaneous Injection|Antibiotic|Older People
Interventions: DRUG: Subcutaneous (SC) route for antibiotic treatment|DRUG: Intravenous (IV) route for antibiotic treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing Neurocognitive Effects of Gluten Exposure
Status: TERMINATED
Conditions: Celiac Disease|Neurobehavioral Manifestations
Interventions: DIETARY_SUPPLEMENT: gluten|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate Efficacy and Safety of Apremilast 30 mg Twice Daily (BID) in Chinese Participants With Moderate to Severe Plaque-type Psoriasis (PsO)
Status: RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: apremilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of QL1206 and Xgeva in Patients With Bone Metastases From Solid Tumors
Status: UNKNOWN
Conditions: Bone Metastases
Interventions: DRUG: QL1206|DRUG: Xgeva
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of 4-aminopyridin (Fampyra) on Gait, Vision, Cognition, Fatigue and Micturation in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis|EDSS 4-7
Interventions: DRUG: Fampyra
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Evaluation of Maxillary Antrostomy Versus Ostial Dilation Efficacy Through Long-Term Follow-Up
Status: COMPLETED
Conditions: Chronic Sinusitis
Interventions: DEVICE: Balloon Sinus Dilation|PROCEDURE: Functional Endoscopic Sinus Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Randomized Trial With Flecainide in ARVC Patients
Status: COMPLETED
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy
Interventions: DRUG: Flecainide Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants With Manifest Huntington's Disease
Status: COMPLETED
Conditions: Huntingtons Disease
Interventions: DRUG: RO7234292|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Versus Opioid Balanced Anesthesia
Status: COMPLETED
Conditions: PONV|Opioid Use
Interventions: DRUG: Fentanyl Opioid anesthesia|DRUG: Saline Nonopioid anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Telerehabilitation Based Exercise Program in Patients With Systemic Sclerosis
Status: UNKNOWN
Conditions: Systemic Sclerosis
Interventions: OTHER: Exercise training group|OTHER: Control training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel and Gemcitabine Plus Camrelizumab and Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: PDAC - Pancreatic Ductal Adenocarcinoma
Interventions: RADIATION: Radiotherapy|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Camrelizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Poly ICLC, Radiation, and Romidepsin for Advanced Cutaneous T Cell Lymphoma
Status: TERMINATED
Conditions: Cutaneous T-cell Lymphoma
Interventions: DRUG: Romidepsin|DRUG: Poly ICLC|RADIATION: Focal lesional radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cross-Sectional Study to Define and Validate "Doctor/Pharmacy Shopping" as Outcomes Suggestive of Abuse and/or Addiction
Status: COMPLETED
Conditions: Opioid-Related Disorders|Opiate Addiction|Narcotic Abuse|Drug Abuse
Interventions: OTHER: DB review for Doctor/Pharmacy Shopping Behavior
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PROVIDENCE-1: Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients
Status: UNKNOWN
Conditions: Peripheral Vascular Diseases|Intermittent Claudication
Interventions: DRUG: Rifalazil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Delayed Release (DR) Risedronate Compared to Immediate Release (IR) in Postmenopausal Women
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: 150 mg|DRUG: 75 mg|DRUG: 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Artificial Intelligence Assisted Socket Shield With Computer Guided Implant Placement
Status: RECRUITING
Conditions: Implant Complication|Dental Implant Failed
Interventions: PROCEDURE: free-hand socket shield|PROCEDURE: AI/guided socket shield
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ecological Effect of Arginine Dentifrice on Oral Microbiota
Status: COMPLETED
Conditions: Dental Caries|Oral Bacterial Infection|Microbiota
Interventions: OTHER: Colgate® Sensitive Pro-Relief® toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the V1a Agonist FE 202158 in Patients With Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: FE 202158 1.25|DRUG: FE 202158 2.5|DRUG: FE 202158 3.75|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Status: RECRUITING
Conditions: Disorders of Sex Development (DSD)|Pediatric and Adolescent Cancers of the Genital Tract|Reproductive Endocrine Conditions in Puberty|Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open-Label Extension Trial of UT-15C Sustained-release (SR) in Subjects With Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Oral Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Cohort Study of Bioabsorbable Screws for Syndesmosis Fixation Fixation in Ankle Fracture
Status: RECRUITING
Conditions: Syndesmotic Injuries|Ankle Fractures|Ankle Injuries and Disorders
Interventions: DEVICE: Syndesmosis fixation using Activascrew
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Assessment of Pharmacokinetic Gemigliptin and Metformin Interactions in Healthy Mexican Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Gemigliptin|DRUG: Gemigliptin 50 mg q.d. + metformin 1000 mg twice a day|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Abicipar Pegol for Safety and Treatment Effect in Participants With Neovascular Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Abicipar pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Proton Pump Inhibitor for Chronic Cough Caused by Gastroesophageal Reflux; Double-blind, Placebo-controlled, Randomized Clinical Trial
Status: COMPLETED
Conditions: Chronic Cough Caused by Gastroesophageal Reflux
Interventions: DRUG: High-dose PPI|DRUG: standard PPI|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Bioavailability of Iron in Iron Fortified Bouillon Cubes in Healthy Nigerian Women
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: OTHER: Meals prepared with iron fortified cube with Low stabilizer level|OTHER: Meals prepared with iron fortified cube with Medium stabilizer level|OTHER: Meals prepared with iron fortified cube with High stabilizer level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Head and Neck Cancer|Radiation Induced Xerostomia|Salivary Hypofunction
Interventions: BIOLOGICAL: AAV2hAQP1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Salicylic and Azaleic Acid Verus Trichloroacetic Acid 25% Peel in Treatment of Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Trichloroacetic acid peel|DRUG: combined azaleic and salicylic acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation of Octreotide-LAR as First-Line Therapy in Resistant Acromegaly
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Octreotide-LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sipuleucel-T Manufacturing Demonstration Study
Status: COMPLETED
Conditions: Cancer of Prostate|Cancer of the Prostate|Neoplasms, Prostate|Neoplasms, Prostatic|Prostate Cancer|Prostate Neoplasms|Prostatic Cancer
Interventions: BIOLOGICAL: sipuleucel-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Gastrointestinal Cancer Metastatic|Neuroendocrine Tumors
Interventions: DRUG: Tirapazamine|PROCEDURE: Conventional Transarterial Embolization (TAE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Subjects to Evaluate the Safety, Tolerability and Pharmacokinetics of GT20029
Status: COMPLETED
Conditions: Androgenetic Alopecia|Acne Vulgaris
Interventions: DRUG: GT20029 Gel|DRUG: GT20029 Gel Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Etelcalcetide in Healthy Male Volunteers
Status: COMPLETED
Conditions: Hyperparathyroidism, Secondary
Interventions: DRUG: Etelcalcetide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Two Different Strengths of DFN-11 Injection for Rapidly Escalating Migraine
Status: COMPLETED
Conditions: Rapidly Escalating Migraine
Interventions: DRUG: DFN-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Selenium on Prostate Cancer Related Biomarkers
Status: COMPLETED
Conditions: Effect of Selenium on Oxidative Stress in Healthy Men
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: selenomethionine|DIETARY_SUPPLEMENT: low dose selenized-yeast|DIETARY_SUPPLEMENT: high dose selenized-yeast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E (BRAFV600E)-Mutant Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Recurrent/Refractory BRAFV600E-mutant Gliomas
Interventions: DRUG: Vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Core Stability Training on Gait in Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis|Gait Disorders, Neurologic
Interventions: OTHER: Physiotherapy - Study group|OTHER: Physiotherapy - control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation With Tiotropium and Olodaterol
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Tiotropium & olodaterol|DRUG: fluticasone furoate & vilanterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of ALKS 8700, a Monomethyl Fumarate (MMF) Molecule, in Healthy Adults
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Study Drug|DRUG: Active Control|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT)
Status: UNKNOWN
Conditions: Dyslipidemia|Atherosclerosis
Interventions: DRUG: simvastatin|DRUG: Nicotinic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MK-7162 in Combination With Pembrolizumab (MK-3475) in Adult Participants With Advanced Solid Tumors (MK-7162-002)
Status: COMPLETED
Conditions: Solid Neoplasms
Interventions: DRUG: MK-7162|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
Status: RECRUITING
Conditions: Polymyositis, Dermatomyositis
Interventions: COMBINATION_PRODUCT: Anifrolumab (blinded)|OTHER: Placebo|COMBINATION_PRODUCT: Anifrolumab (unblinded, open label)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cediranib Plus Cisplatin Plus Capecitabine/S-1 in Japanese Gastric Cancer Patients
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Cediranib|DRUG: Cisplatin|DRUG: S-1|DRUG: Cisplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Fluids Versus Naso/Orogastric-tube Feeding in Hospitalized Infants With Bronchiolitis
Status: COMPLETED
Conditions: Viral Bronchiolitis
Interventions: PROCEDURE: IV fluids|PROCEDURE: Naso/oro gastric tube feedings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neonatal Sleep Intervention to Improve Postpartum Hypertension
Status: COMPLETED
Conditions: Pre-Eclampsia|Gestational Hypertension|Sleep
Interventions: DEVICE: SNOO|OTHER: Safe sleep education in the postpartum period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Low-Magnitude, High Frequency Vibration Treatment on Femoral Shaft Fracture Healing
Status: COMPLETED
Conditions: Fracture, Closed, Comminuted, Healing
Interventions: PROCEDURE: vibration platform provide low magnitude and high frequency vibration treatment, which is self-developed by our research team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune-Mediated Pathophysiology And Clinical Triage Program
Status: RECRUITING
Conditions: Arthritis|Arthralgia
Interventions: DRUG: Hydroxychloroquine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Value of Multiple Urine Flow Rate Measurements in Male Benign Prostatic Hyperplasia (BPH) Subjects
Status: COMPLETED
Conditions: Bladder Outlet Obstruction|Lower Urinary Tract Symptoms
Interventions: DEVICE: Disposable device|DEVICE: Digital device|DEVICE: Clinic flow measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of CoQ10 on Inflammatory Response in Cardiac Surgery
Status: UNKNOWN
Conditions: Cardiovascular Disease
Interventions: DRUG: Coenzyme Q10|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: STHLM3 - Prostate Cancer Diagnostic Trial
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: STHLM3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastases
Status: RECRUITING
Conditions: Clinical Stage IV Cutaneous Melanoma AJCC v8|Melanoma of Unknown Primary|Metastatic Malignant Neoplasm in the Brain|Metastatic Melanoma|Metastatic Mucosal Melanoma|Metastatic Ocular Melanoma|Pathologic Stage IV Cutaneous Melanoma AJCC v8
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|BIOLOGICAL: Pembrolizumab|RADIATION: Stereotactic Radiosurgery|PROCEDURE: Tumor Treating Fields Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Demcizumab Plus Paclitaxel in Subjects With Platinum Resistant Ovarian
Status: TERMINATED
Conditions: Primary Peritoneal Carcinoma
Interventions: DRUG: Demcizumab|DRUG: Taxol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT