pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effectiveness of an Integrated Colorectal Cancer Screening in Saudi Arabia: A Pragmatic Randomized Trial
Status: COMPLETED
Conditions: Colorectal Neoplasms|Colorectal Cancer|Colonic Polyp|Occult Bleeding
Interventions: DIAGNOSTIC_TEST: Stool for Occult Blood Test and Colonoscopy with comprehensive medical checkups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU II)
Status: RECRUITING
Conditions: Diabetic Foot Infection|Non-healing Wound|Non-healing Diabetic Foot Ulcer
Interventions: BIOLOGICAL: TTAX01|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Nasogastric Tube Gastric Decompression on Postoperative Nausea and Vomiting in Orthognathic Surgery
Status: NOT_YET_RECRUITING
Conditions: Postoperative Nausea|Postoperative Vomiting
Interventions: PROCEDURE: No NG tube gastric decompression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Radiographic Assessment of Calcific Bridge Formation by Light Activated Calcium Silicate Versus Calcium Hydroxide for Deep Caries
Status: UNKNOWN
Conditions: Deep Carious Lesions
Interventions: OTHER: light activated calcium silicate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction
Status: RECRUITING
Conditions: Bone Loss, Alveolar
Interventions: DRUG: Soludronate®|DRUG: sterile saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis
Status: ENROLLING_BY_INVITATION
Conditions: Idiopathic Pulmonary Fibrosis|Interstitial Lung Disease
Interventions: DRUG: Inhaled Treprostinil|DEVICE: Treprostinil Ultrasonic Nebulizer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MAGE-A3 and NY-ESO-1 Immunotherapy in Combo With DTPACE Chemo and Auto Transplantation in Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: MAGE-A3|BIOLOGICAL: MAGE-A3 AND NY-ESO-1 IMMUNOTHERAPY
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients
Status: COMPLETED
Conditions: Post Extubation Respiratory Failure|Re-intubation|Septic Shock|Severe Sepsis
Interventions: DEVICE: Noninvasive positive pressure ventilation|DEVICE: High flow oxygen nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Iron Prehabilitation in Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer|Perioperative Complication|Prehabilitation
Interventions: DRUG: Ferrous Gluconate 300 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of DTap-IPV Compared to DAPTACEL® and IPOL® as the 5th Dose in Children 4 to 6 Years of Age
Status: COMPLETED
Conditions: Tetanus|Diphtheria|Pertussis|Measles|Polio
Interventions: BIOLOGICAL: Diphtheria and Tetanus Toxoids and Acellular Pertussis + Measles, Mumps, Rubella + Varicella Virus|BIOLOGICAL: Diphtheria and Tetanus Toxoids and Acellular Pertussis + Poliovirus + MMR + Varicella Virus|BIOLOGICAL: Diphtheria and Tetanus Toxoids and Acellular Pertussis + Measles, Mumps, Rubella + Varicella Virus|BIOLOGICAL: Diphtheria and Tetanus Toxoids and Acellular Pertussis + Poliovirus + MMR + Varicella Virus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Field Administration of Stroke Therapy-Blood Pressure Lowering
Status: TERMINATED
Conditions: Intracerebral Hemorrhage|Ischemic Stroke
Interventions: DRUG: Glycerly Trinitrate|DRUG: Glycerly Trinitrate|DRUG: Glycerly Trinitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reengineering Methadone Treatment Study of Patient-centered Methadone Treatment
Status: COMPLETED
Conditions: Opiate Dependence
Interventions: OTHER: Patient-Centered Methadone Treatment|OTHER: Methadone Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Different Window-preparation Approaches on the Clinical Outcomes of Lateral Sinus Floor Elevation
Status: COMPLETED
Conditions: Dental Implantation|Cone-Beam Computed Tomography|Surgical Procedure, Unspecified|Maxillary Sinus Floor Augmentation
Interventions: PROCEDURE: Piezoelectric osteotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: the Effect of High Caloric Oral Nutritional Supplements on Growth and Development of Malnourished Children
Status: NOT_YET_RECRUITING
Conditions: Malnutrition, Child|Malnourishment|Nutritional Deficiency|Undernutrition
Interventions: DIETARY_SUPPLEMENT: high caloric oral nutritional supplements|BEHAVIORAL: nutritional education|BEHAVIORAL: dietary guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Irinotecan and Bevacizumab With Temozolomide in Refractory/Relapsed Central Nervous System (CNS) Tumors
Status: COMPLETED
Conditions: Central Nervous System Tumors
Interventions: DRUG: Bevacizumab|DRUG: Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Supplementation With Multi-vitamins/Minerals, With and Without Fatty Acids, on Impulsivity and Aggression
Status: COMPLETED
Conditions: Aggression
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Multi-vitamin/mineral|DIETARY_SUPPLEMENT: Docosahexaenoic acid|DIETARY_SUPPLEMENT: DHA plus vitamins/minerals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reducing Acute Kidney Injury Occurence by Administering Angiotensin II
Status: COMPLETED
Conditions: Cardiac Surgery|Vasoplegia|Hyperreninemia
Interventions: DRUG: Angiotensin II|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Dactinomycin and Vincristine in Young Patients With Cancer
Status: COMPLETED
Conditions: Childhood Acute Lymphoblastic Leukemia|Childhood Rhabdomyosarcoma|Childhood Soft Tissue Sarcoma|Ewing Sarcoma|Ewing Sarcoma of Bone|Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor (PNET)|Unspecified Childhood Solid Tumor, Protocol Specific|Wilms Tumor and Other Childhood Kidney Tumors
Interventions: OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Veltuzumab and Fractionated 90Y- Epratuzumab Radioimmunotherapy in Follicular Lymphoma
Status: TERMINATED
Conditions: Follicular Lymphoma
Interventions: DRUG: 90Y-epratuzumab tetraxetan|BIOLOGICAL: veltuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DHEA Versus Placebo in Women With Poor Ovarian Response
Status: UNKNOWN
Conditions: Subfertility
Interventions: DRUG: DHEA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Spinal Cord Stimulation (SCS) in Painful Diabetic Polyneuropathy
Status: UNKNOWN
Conditions: Diabetic Neuropathies|Pain|Electric Stimulation Therapy
Interventions: PROCEDURE: Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrombolysis and RIPC in Acute Ischemic Stroke
Status: COMPLETED
Conditions: Acute Ischemic Stroke, Cerebral Embolism and Thrombosis
Interventions: DEVICE: RIPC device (IPC-906X)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of State-of-the-Art Exoskeleton Technology to Improve Mobility in Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson Disease
Interventions: DEVICE: Robotic-assist gait training device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patient Decision Aid in Supporting Decision-Making About When to Start or Stop New Drugs, Join Clinical Trials, or Continue Active Surveillance in Patients With Medullary Thyroid Cancer and Their Caregivers
Status: RECRUITING
Conditions: Thyroid Gland Medullary Carcinoma
Interventions: OTHER: Decision Aid|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Heparin, Low-Molecular-Weight|DRUG: no heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ventilation Strategy for the Elderly Patients in Prone Position
Status: UNKNOWN
Conditions: Ventilators, Mechanical
Interventions: PROCEDURE: ventilator setting vcv with pause|PROCEDURE: ventilator setting vcv|PROCEDURE: ventilator setting pcv-vg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study For Treatment of Paroxysmal Atrial Fibrillation (PAF) With the OMNYPULSE Catheter and the TRUPULSE Generator
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: OMNYPULSE Bi-Directional Catheter with TRUPULSE Generator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0
Status: NOT_YET_RECRUITING
Conditions: E-Cig Use
Interventions: OTHER: E-liquid coolant (WS-3, 0.05%)|OTHER: E-liquid coolant (WS-3, 0.1%)|OTHER: E-liquid coolant (WS-3, 0.5%)|OTHER: E-liquid coolant (WS-3, 1.0%)|OTHER: E-liquid coolant (WS-3, 2.0%)|OTHER: E-liquid coolant (menthol, 0.05%)|OTHER: E-liquid coolant (menthol, 0.1%)|OTHER: E-liquid coolant (menthol, 0.5%)|OTHER: E-liquid coolant (menthol, 1.0%)|OTHER: E-liquid coolant (menthol, 2.0%)|OTHER: E-liquid coolant (WS-23, 0.05%)|OTHER: E-liquid coolant (WS-23, 0.1%)|OTHER: E-liquid coolant (WS-23, 0.5%)|OTHER: E-liquid coolant (WS-23, 1.0%)|OTHER: E-liquid coolant (WS-23, 2.0%)|OTHER: E-liquid coolant (WS-23, 4.0%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Alternative Delivery of Dose Adjustment For Normal Eating (DAFNE) Trial in Patients With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: DAFNE course (Timing of delivery of education)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Valsartan in Hypertensive Non Responders Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Carboplatin, and Topotecan in Treating Patients With Relapsed/Refractory Acute Leukemia or Advanced Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: carboplatin|DRUG: fludarabine phosphate|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed With or Without Carboplatin for Elderly Non-squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: PemCarbo|DRUG: Pem only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of Pocket-size Lung Ultrasound in Pneumonia Etiology and Complications in Hospitalized Children
Status: NOT_YET_RECRUITING
Conditions: Pneumonia|Pneumonia, Viral|Pneumonia, Bacterial
Interventions: DEVICE: Pocket-size lung ultrasound for etiological definition of pneumonia and surveillance of complications in children hospitalized
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of CAMBRA Versus ICCMS Caries Risk Assessment Models Acquisition On Treatment Plan
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: ICCM|OTHER: CAMBRA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Panitumumab|RADIATION: Intensity Modulated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: MEDI7219|DRUG: Placebo|DRUG: Formulation without Active Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Everolimus in the Treatment of Neurocognitive Problems in Tuberous Sclerosis
Status: UNKNOWN
Conditions: Tuberous Sclerosis
Interventions: DRUG: Placebo|DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Residual Hypermetropic Refraction on Young Patients After LASIK Using Human Fresh Corneal Lenticule Implantation With ReLEX Smile Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Refractive Errors
Interventions: DEVICE: ReLex Smile
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicentre Phase I Trial of Engineered T Cells for Patients With Relapsed or Refractory Primary Cutaneous CD30+ Large T Cell Lymphoma or Transformed CD30+ Mycosis Fungoides
Status: UNKNOWN
Conditions: CD30 Positive Cutaneous T Cell Lymphoma|CD30 Positive Transformed Mycosis Fungoides
Interventions: GENETIC: Genetically modified T cells # 1138
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS)
Status: TERMINATED
Conditions: Urinary Tract Infection
Interventions: DRUG: Fosfomycin tromethamine|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Enzalutamide (MDV3100) in Patients With Incurable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: enzalutamide|DRUG: anastrozole|DRUG: exemestane|DRUG: fulvestrant|DRUG: enzalutamide|DRUG: exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Down Syndrome|Myelodysplastic Syndrome|Myeloid Leukemia Associated With Down Syndrome|Myeloproliferative Neoplasm
Interventions: DRUG: Asparaginase|DRUG: Asparaginase Erwinia chrysanthemi|DRUG: Cytarabine|DRUG: Daunorubicin Hydrochloride|DRUG: Etoposide|OTHER: Laboratory Biomarker Analysis|DRUG: Mitoxantrone Hydrochloride|DRUG: Thioguanine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome
Status: TERMINATED
Conditions: Marfan Syndrome
Interventions: DRUG: placebo|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aflibercept|DRUG: Faricimab|PROCEDURE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Based Stress Reduction and Post-Stroke Cognition
Status: COMPLETED
Conditions: Stroke|Stroke Sequelae|Depression|Cognitive Impairment
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction (MBSR)|BEHAVIORAL: Stroke Support Group (SSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Combination of Synthetic Bone Substitutes During Extractions
Status: UNKNOWN
Conditions: Periodontitis|Dental Caries|Alveolar Bone Losses
Interventions: DEVICE: Calcium Phosphate, Calcium Sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-centre, Randomised, Double-blind, Controlled, Parallel-group Study to Evaluate the Effect of a Fermented Dairy Product on Abdominal Distension, Digestive Symptoms and Rectal Sensitivity in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Status: COMPLETED
Conditions: Women With IBS-C
Interventions: OTHER: 1-fermented dairy product|OTHER: 2- milk-based non-fermented dairy product (control product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of Grass Pollen Allergen Concentration Inducing Rhinoconjunctivitis Symptoms in Subjects Allergic to Grass Pollen in ALYATEC Allergen Exposure Chamber
Status: COMPLETED
Conditions: Allergic Rhinitis Due to Grass Pollen
Interventions: OTHER: Grass Pollen Allergen Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Direct Superior Approach (DSA) vs Posterior Approach (PA) in THA
Status: COMPLETED
Conditions: Surgery|Surgical Incision|Patient Satisfaction
Interventions: DEVICE: Total hip arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Procedures for a Study of the AYA Survivors Coping and Emotional Needs Toolkit
Status: NOT_YET_RECRUITING
Conditions: Depression|Cancer|Adolescent|Young Adult|Adult
Interventions: BEHAVIORAL: AYA Survivors Coping and Emotional Needs Toolkit (ASCENT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF
Status: UNKNOWN
Conditions: Infertility, Female|Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: FertyBiotic Woman Plus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome
Status: COMPLETED
Conditions: Cardiovascular Disease|Metabolic Syndrome|Obesity
Interventions: OTHER: Low-Fat Milk|OTHER: Rice Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Bioavailability of a Single Oral Dose of the Acetylsalicylic Acid Containing Dry Powder 500 mg in Comparison to the Bioavailability of a Single Oral Dose of Aspirin Tablets and Aspirin Effervescent Tablets in Healthy Adults.
Status: COMPLETED
Conditions: Pharmacology, Clinical
Interventions: DRUG: Aspirin (Acetylsalicylic acid, BAYe4465)|DRUG: Aspirin (Acetylsalicylic acid, BAYe4465)|DRUG: Aspirin (Acetylsalicylic acid, BAYe4465)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Melphalan Flufenamide (Melflufen) Plus Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Melphalan flufenamide (Melflufen)|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flavonoids, Blood Pressure and Blood Vessel Function
Status: COMPLETED
Conditions: Cardiovascular Disease Risk Reduction
Interventions: DIETARY_SUPPLEMENT: Flavanone - supplement|OTHER: Flavanone - food|OTHER: Flavanone - placebo|DIETARY_SUPPLEMENT: Isoflavone - supplement|OTHER: Isoflavone - food|OTHER: Isoflavone - placebo|DIETARY_SUPPLEMENT: Isoflavone - metabolite supplement|DIETARY_SUPPLEMENT: Flavan-3-ol - supplement|OTHER: Flavan-3-ol - food|OTHER: Flavan-3-ol - placebo|DIETARY_SUPPLEMENT: Anthocyanin - supplement|OTHER: Anthocyanin - food|OTHER: Anthocyanin - placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ocular Manifestations in Rheumatic Diseases
Status: COMPLETED
Conditions: Uveitis|Conjunctivitis|Keratoconjunctivitis Sicca|Xerophthalmia|Eye Hemorrhage|Optic Neuritis|Papilledema|Orbital Diseases|Retinal Vein Occlusion|Retinal Artery Occlusion|Macular Edema|Retinitis|Chorioretinitis|Iridocyclitis|Scleritis|Choroid Hemorrhage|Blindness|Amaurosis Fugax
Interventions: OTHER: No intervention used
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of Pravafenix Cap to Verify the Superiority Than Atorvastatin
Status: COMPLETED
Conditions: Combined Dyslipidemia
Interventions: DRUG: Pravastatin40mg/Fenofibrate160mg|DRUG: Atorvastatin Sodium 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of XPO1 Inhibitor Selinexor Combined With COPL in Newly Diagnosed Advanced NK/T-cell Lymphoma
Status: RECRUITING
Conditions: nk/T-cell Lymphoma|Newly Diagnosed|Advanced Lymphoma
Interventions: DRUG: XPO1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of SARPE With 3 and 2-Segment Technique: A Randomized Clinical Trial
Status: UNKNOWN
Conditions: Maxillary Hypoplasia
Interventions: OTHER: 2-Segment SARPE|OTHER: 3-Segment SARPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Ultrasonographic Assessment of Optic Nerve Sheath Diameter in Children Receiving Caudal Block
Status: COMPLETED
Conditions: Orchiopexy|Inguinal Hernioplasty|Hydrocelectomy|Diverticulectomy|Fistula Repair|Penoplasty
Interventions: DRUG: 1.0 ml/kg of 0.15% ropivacaine|DRUG: 1.5 ml/kg of 0.15% ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug Interaction Study Between Inhaled Beclomethasone and Protease Inhibitors in Healthy Volunteers
Status: COMPLETED
Conditions: HIV|Asthma
Interventions: DRUG: Darunavir|DRUG: Ritonavir|DRUG: Beclomethasone Dipropionate HFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cryoablation of Bone Metastases From Endocrine Tumors
Status: TERMINATED
Conditions: Neoplasm Metastasis|Thyroid Neoplasm|Pheochromocytoma|Adrenal Neoplasm|Neuroendocrine Tumors|Bone Metastases
Interventions: DEVICE: cryoablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Treatment of Differentiated Thyroid Carcinoma With Anlotinib
Status: ACTIVE_NOT_RECRUITING
Conditions: DTC - Differentiated Thyroid Cancer
Interventions: DRUG: Anlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Effect of Glucocil® on Metabolic Health in Individuals With Prediabetes and Type 2 Diabetes Mellitus.
Status: NOT_YET_RECRUITING
Conditions: Pre Diabetes|Type2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: IP 1200 mg per soft gel capsule|DIETARY_SUPPLEMENT: Placebo Comparator: Placebo 1200 mg per soft gel capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Spastic Cerebral Palsy
Interventions: OTHER: Botulinum Toxin treatment combined with a post-BoNT intensive physical therapy period guided by individualized treatment goals.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A SHR3680 QT/QTc Study on Castration-Resistant Prostate Cancer Subjects
Status: RECRUITING
Conditions: Castration-Resistant Prostate Cancer
Interventions: DRUG: SHR3680 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GaslEss Macular Hole Surgery
Status: NOT_YET_RECRUITING
Conditions: Macular Holes
Interventions: PROCEDURE: Gasless Macular hole surgery|PROCEDURE: Standard Macular hole surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Interest of the Virtual Reality Headset in the Management of Perioperative Stress in Patients Candidates for Total Thyroidectomy
Status: RECRUITING
Conditions: Thyroid Cancer|Thyroidectomy
Interventions: BEHAVIORAL: Use of a virtual reality headset
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pulsed Electromagnetic Fields for Analgesia Post Mastectomy
Status: RECRUITING
Conditions: Female Breast Cancer|Post Operative Pain
Interventions: DEVICE: Active AlgoCare|DEVICE: Non-active AlgoCare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Point-of-Care HIV Testing and Early Dolutegravir Use for Infants
Status: RECRUITING
Conditions: HIV
Interventions: DIAGNOSTIC_TEST: Point-of-Care Cepheid Xpert HIV-1|DRUG: DTG/ABC/3TC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Enzalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Building a Healthy Temple: a Diabetes Self-management Support Program in Hispanic Faith Community Settings
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus
Interventions: BEHAVIORAL: Faith-Based (FB, BHT DSMS)|OTHER: Faith-Placed (FP, Stanford DSMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single and Repeat Dose First Time in Human Study for an Intranasal H1/H3 Dual Antagonist in Healthy Male Subjects
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: DRUG: GSK1004723|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Tetracaine Compared to Placebo for Reducing Pain With Palivizumab - A Pilot Study
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: tetracaine 4% gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 3 Clinical Trial to Assess the Effectiveness of BioChaperone PDGF-BB In the Treatment of Chronic Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: BioChaperone PDGF-BB|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Quetiapine on Methamphetamine-Induced Psychosis
Status: COMPLETED
Conditions: Methamphetamine-induced Psychosis
Interventions: DRUG: Diazepam|DIETARY_SUPPLEMENT: Vitamin B1-6-12|DRUG: Stugeron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rosiglitazone Effects on Cognition for Adults in Later Life
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine in Treating Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Iodine I 131
Status: COMPLETED
Conditions: Recurrent Thyroid Cancer|Stage IVA Follicular Thyroid Cancer|Stage IVA Papillary Thyroid Cancer|Stage IVB Follicular Thyroid Cancer|Stage IVB Papillary Thyroid Cancer|Stage IVC Follicular Thyroid Cancer|Stage IVC Papillary Thyroid Cancer
Interventions: DRUG: Decitabine|RADIATION: Iodine I 131|BIOLOGICAL: Recombinant thyrotropin alfa|RADIATION: Fludeoxyglucose F 18|PROCEDURE: Positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Prucalopride Plus Polyethylene Glycol in Bowel Preparation for Colonoscopy
Status: UNKNOWN
Conditions: Prucalopride Plus Polyethylene Glycol in Bowel Preparation for Colonoscopyp
Interventions: DRUG: 2 mg Prucalopride plus 2 L Polyethylene Glycol regimen|DRUG: 2 mg Placebo plus 2 L Polyethylene Glycol regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Danoprevir in Combination With Low-Dose Ritonavir in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: danoprevir|DRUG: danoprevir|DRUG: danoprevir placebo|DRUG: moxifloxacin|DRUG: moxifloxacin placebo|DRUG: ritonavir|DRUG: ritonavir placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Safety and Efficacy Study of Ravulizumab in Adults With Generalized Myasthenia Gravis
Status: COMPLETED
Conditions: Generalized Myasthenia Gravis
Interventions: BIOLOGICAL: Ravulizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Early Home-based Strength and Sensory-motor Training After THA on Functional Outcome and Patient Satisfaction
Status: COMPLETED
Conditions: Arthroplasty|Replacement|Hip|Strength Training
Interventions: PROCEDURE: Strength and Sensory-Motor Training|PROCEDURE: Current Standard Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I/II Study of Nivolumab, Ipilimumab and Plinabulin in Patients With Recurrent Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|SCLC
Interventions: DRUG: Nivolumab|DRUG: Plinabulin|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthritis
Status: RECRUITING
Conditions: Periodontal Diseases|Rheumatoid Arthritis
Interventions: OTHER: Non surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Vitamin D3 Improve Cognitive Function in Individuals With Type 2 Diabetes? (THINK-D)
Status: TERMINATED
Conditions: Diabetes|Executive Dysfunction
Interventions: DRUG: Cholecalciferol|DRUG: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Saccharomyces Cerevisiae on Vulvo-vaginal Candidiasis
Status: TERMINATED
Conditions: Candidiasis, Vulvovaginal
Interventions: DEVICE: Saccharomyces cerevisiae|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Glioblastoma Multiforme|Glioblastoma, Adult|Glioblastoma|Recurrent Brain Tumor|GBM
Interventions: DRUG: Sunitinib|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Duvelisib in Combination With Pembrolizumab in Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Duvelisib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intravenous Autologous Mesenchymal Stem Cells for MS: a Phase 2 Proof of Concept Study
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietary Treatment of Endometriosis-related Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Endometriosis|Irritable Bowel Syndrome|Visceral Syndrome|Visceral Hypersensitivity
Interventions: OTHER: Diet low in fermentable carbohydrates (low FODMAP diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: High and Low Resource Interventions to Promote HPV Vaccines
Status: COMPLETED
Conditions: Human Papilloma Virus|Tdap - Tetanus, Diphtheria and Acellular Pertussis Vaccination|Meningitis, Meningococcal|Communication|Satisfaction
Interventions: BEHAVIORAL: AFIX Only|BEHAVIORAL: AFIX+ Provider Communication Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Clinical Trial to Study the Safety, Tolerance and Immunogenic Response to Gardasil and Bivalent rLP2086 Vaccine When Given at the Same Time to Children Between the Ages of 11 and 17
Status: COMPLETED
Conditions: Vaccines|Meningococcal Vaccines
Interventions: BIOLOGICAL: rLP2086 and Gardasil|BIOLOGICAL: rLP2086|BIOLOGICAL: Gardasil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee
Status: COMPLETED
Conditions: Cartilage Ulceration of the Distal Joints
Interventions: DEVICE: CBCT prior to MDCT|DEVICE: MDCT prior to CBCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Upwards Laryngeal Handshake Technique and Simple Palpation for Locating the Cricoid Cartilage
Status: NOT_YET_RECRUITING
Conditions: Technique for Locating the Cricoid Cartilage
Interventions: OTHER: The cricoid cartilage is located.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: gabapentin|DRUG: Tramadol|DRUG: Ibuprofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Innovative Disease-net Management Model for Non-communicable Diseases (SIDERA^B)
Status: UNKNOWN
Conditions: Parkinson Disease (PD)|Chronic Heart Failure (CHF)|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: SIDERA^B|BEHAVIORAL: Usual Care Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of INCB054707 in Participants With Prurigo Nodularis
Status: COMPLETED
Conditions: Prurigo Nodularis
Interventions: DRUG: INCB054707|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study for the Management of Chronic and Functional Constipation Through the Intake of Probiotics and Prebiotics
Status: COMPLETED
Conditions: Functional Constipation
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Prebiotic|DIETARY_SUPPLEMENT: Probiotic + Prebiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Adults and Adult Subjects With Rheumatoid Arthritis to Evaluate the Safety, Tolerability and Pharmacokinetics After Multiple Doses of ABT-494
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: ABT-494|DRUG: Placebo|DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Study of Inhaled GB002 for Treatment of WHO Group I Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: GB002|DRUG: Placebo|DEVICE: Generic Dry Powder Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Virtual Reality in Pain Reduction in Orthopedic Pediatric Patients
Status: COMPLETED
Conditions: Orthopedic Disorder|Fractures, Bone
Interventions: BEHAVIORAL: Virtual Reality Headset and handheld remote control.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GnRH Agonist for Luteal Phase Support.
Status: UNKNOWN
Conditions: Use of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles
Interventions: DRUG: GnRH agonist|DRUG: Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Efficacy of Digestive Enzymes on Inflammation After a Meal
Status: UNKNOWN
Conditions: Post Prandial Inflammation Markers
Interventions: DIETARY_SUPPLEMENT: Digestive Enzyme #2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Pharmacokinetic Profiles and Safety of CKD-393
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: CKD-393|DRUG: CKD-501, D759, H053
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Versus Dexmedetomidine as Adjuvants for Nerve Blocks
Status: COMPLETED
Conditions: Pain, Postoperative|Pain, Acute|Upper Extremity Injury
Interventions: DRUG: Dexamethasone|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Normobaric Hyperoxia Combined With Intravenous Thrombolysis for Acute Ischemic Stroke：Longterm Outcome (OPENS-3L)
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Normobaric Hyperoxia|DEVICE: Nasal oxygen|DRUG: Intravenous thrombolysis(rt-PA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Plaque Removal of a Novel Brushing Device
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DEVICE: Automated mouthpiece-based toothbrush|DEVICE: Manual toothbrush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Psychological Group Rehabilitation for Patients With Chronic Fatigue Syndrome (ME/CFS)
Status: RECRUITING
Conditions: Psychological Adaptation|Cognitive Change|Adaptive Behavior|Functioning
Interventions: BEHAVIORAL: Health Psychological Group Rehabilitation for Patients With Chronic Fatigue Syndrome (ME/CFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Status: COMPLETED
Conditions: Sepsis|Critical Illness|Respiratory Failure|Nutrition Disorders|Calorie Deficiency|Diaphragm Injury|Quadriceps Muscle Atrophy
Interventions: OTHER: Caloric delivery will target results of IC measurement.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of the Precision SCS Systems Adapted for High-Rate Spinal Cord Stimulation
Status: COMPLETED
Conditions: Chronic Pain|Back Pain
Interventions: DEVICE: PRECISION SCS Adapted for High-Rate SCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Pulse Wave and Blood Pressure Measurements Before, During and After Ergometry in Healthy Women
Status: COMPLETED
Conditions: Healthy Female Subjects
Interventions: OTHER: Ergometry H|OTHER: Ergometry L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Promethazine vs. Lorazepam for Treatment of Vertigo
Status: COMPLETED
Conditions: Peripheral Vertigo.
Interventions: DRUG: Promethazine|DRUG: Lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT