pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Investigation of Newly Developed 1-piece Convex Baseplates in Subjects With Ileostomy
Status: COMPLETED
Conditions: Ileostomy - Stoma
Interventions: DEVICE: Coloplast Test 1|DEVICE: Coloplast Test 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of a Mobile Application as an Adjunct to Medical Advice to Promote Healthy Habits
Status: UNKNOWN
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: APP + health advice|BEHAVIORAL: health advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Caffeine on Heart Rate Variability in Newborns
Status: COMPLETED
Conditions: Caffeine|Heart Rate Variability|Apnoea of Newborn|Newborn
Interventions: DIAGNOSTIC_TEST: Electrocardiogram|DIAGNOSTIC_TEST: Monitoring of vital functions|DRUG: Caffeine Citrate 5 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Donepezil Hydrochloride in Preadolescent and Adolescent Children With Attention Impairment Following Cancer Treatment
Status: COMPLETED
Conditions: Attention Impairment
Interventions: DRUG: Donepezil hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease
Status: COMPLETED
Conditions: Platelet Dysfunction Due to Drugs
Interventions: DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Self Tonometry and Transfer of Glaucoma Patients' Data for Improving the Supply Situation
Status: COMPLETED
Conditions: Glaucoma|Intraocular Pressure|Patient Empowerment|Telemedicine
Interventions: PROCEDURE: Self-tonometry by means of ICareHOME|PROCEDURE: Intraocular measurement by means of rebound tonometry or Goldmann applanation tonometry|PROCEDURE: Blood pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Outcomes of Extensive Brilliant Blue G-Assisted Internal Limiting Membrane Peeling in Proliferative Vitreoretinopathy
Status: COMPLETED
Conditions: Proliferative Vitreoretinopathy
Interventions: PROCEDURE: 3D Pars Plana Vitrectomy associated with Extensive Brilliant Blue G-Assisted ILM Peeling Method
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Effects of Cryotherapy and Infrared Light on Pain, Redness, and Healing of Episiotomy Wound
Status: RECRUITING
Conditions: Episiotomy Wound
Interventions: OTHER: Cryotherapy|DEVICE: Infrared light therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study of CT053PTSA in Relapsed / Refractory Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Acute Myeloid Leukemia (AML)
Interventions: DRUG: CT053PTSA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Redox Imbalance and the Development of Cystic Fibrosis Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Cystic Fibrosis
Interventions: OTHER: Oral Glucose Tolerance Test|OTHER: High Glycemic Index Meal|OTHER: Low Glycemic Index Meal|OTHER: Test Soda|OTHER: Fruit juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Adipose Tissue Derived Mesenchymal Stem Cells as Osteogenic Component in Composite Grafts
Status: TERMINATED
Conditions: Osteoporotic Fractures
Interventions: PROCEDURE: Cellularized composite graft augmentation|PROCEDURE: Acellular composite graft augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Surgery With or Without Radiation Therapy in Treating Patients With Stage 2 or Stage 3 Neuroblastoma
Status: UNKNOWN
Conditions: Neuroblastoma
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: vincristine sulfate|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FSME IMMUN NEW Follow-up to Study 208 in Volunteers Aged 16 to 66 Years
Status: COMPLETED
Conditions: Encephalitis, Tick-borne
Interventions: BIOLOGICAL: Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of a Smartphone App. Designed to Manage Craving & Individual Predictors of Substance Use/Addictive Behavior
Status: RECRUITING
Conditions: Addiction
Interventions: OTHER: Smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Quantitative Fluorescence Molecular Imaging of Ustekinumab-800CW to Elucidate the Drug Distribution Throughout Inflamed Tissue in Crohn's Disease and Psoriasis.
Status: NOT_YET_RECRUITING
Conditions: Psoriasis|Crohn Disease
Interventions: DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal in Healthy Subjects
Status: UNKNOWN
Conditions: Hyperglycemia, Postprandial|Healthy
Interventions: DIETARY_SUPPLEMENT: Enriched pomegranate juice|DIETARY_SUPPLEMENT: Placebo beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization
Status: COMPLETED
Conditions: Corneal Neovascularization
Interventions: DRUG: Bevacizumab (Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Designed Protocol of Care for Postpartum Perineal Trauma
Status: COMPLETED
Conditions: Perineal Injury
Interventions: OTHER: 1-perineal ice-gel pad application|OTHER: 2-performance of pelvic floor exercises (Kegel exercises)|OTHER: 3- perineal warm compresses application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential CAR-T Cells Therapy for CD5/CD7 Positive T-cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Using CD5/CD7-Specific CAR-T Cells
Status: RECRUITING
Conditions: T Cell Lymphoma|T Cell Leukemia|T-cell Acute Lymphoblastic Leukemia|T-Cell Lymphoma of CNS|T Cell Prolymphocytic Leukemia|T Cell Childhood ALL
Interventions: BIOLOGICAL: CD5/CD7 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ukulele Playing to Improve Cognition in People With Multiple Sclerosis: A Feasibility Study
Status: RECRUITING
Conditions: Multiple Sclerosis|Pathologic Processes|Demyelinating Autoimmune Diseases, CNS|Autoimmune Diseases of the Nervous System|Nervous System Diseases|Demyelinating Diseases|Autoimmune Diseases|Immune System Diseases
Interventions: BEHAVIORAL: Music Training Intervention|BEHAVIORAL: Music Listening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Food Effect Study of Abiraterone Acetate for Treatment of Patients With Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration-resistant Prostate Cancer|Stage IV Prostate Cancer
Interventions: DRUG: abiraterone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Copper Cu 64-DOTA-Trastuzumab PET in Predicting Response to Treatment With Ado-Trastuzumab Emtansine in Patients With Metastatic HER2 Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bone Metastases|HER2-positive Breast Cancer|Liver Metastases|Lung Metastases|Recurrent Breast Cancer|Soft Tissue Metastases|Stage IV Breast Cancer
Interventions: RADIATION: fludeoxyglucose F 18|PROCEDURE: positron emission tomography|PROCEDURE: computed tomography|BIOLOGICAL: trastuzumab|RADIATION: copper Cu 64-DOTA-trastuzumab|PROCEDURE: positron emission tomography|BIOLOGICAL: ado-trastuzumab emtansine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acupoint Stimulation and Postoperative Sleep
Status: COMPLETED
Conditions: Anesthesia|Sleep
Interventions: OTHER: transcutaneous electrical acupoint stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Trial of Low-Dose Interleukin-2 (IL-2) Added to Extra-Corporeal Photopheresis for Steroid-Refractory cGVHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Graft-versus-host-disease
Interventions: PROCEDURE: Extracorporeal Photopheresis (ECP)|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oromucosal Nicotine Spray (ONS)|DRUG: Nicotine Gum|OTHER: Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: TST002 Intervenous Injection in Postmenopausal Women and Men With Reduced Bone Mineral Density
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: DRUG: TST002 Injection|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine Serum and Skin Biopsy Biomarkers in Patients Receiving Topical Corticosteroid (TCS) and Following TCS Withdrawal
Status: TERMINATED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Triamcinolone 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EHealth Mindful Movement and Breathing in Improving Outcomes in Participants Undergoing Gynecologic Surgery
Status: COMPLETED
Conditions: Female Reproductive System Neoplasm|Malignant Female Reproductive System Neoplasm|Malignant Uterine Neoplasm|Ovarian Carcinoma|Ovarian Neoplasm|Suspicious for Malignancy|Uterine Neoplasm
Interventions: OTHER: Questionnaire Administration|PROCEDURE: Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of MET and AIS on Erector Spinae Muscle in Low Back Pain
Status: COMPLETED
Conditions: Mechanical Low Back Pain
Interventions: OTHER: Muscle Energy Technique|OTHER: Active Isolated Stretching|OTHER: Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Technetium Tc 99m Sulfur Colloid and Blue Dye In Detecting Sentinel Lymph Nodes in Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: patent blue V dye|PROCEDURE: radionuclide imaging|PROCEDURE: sentinel lymph node biopsy|RADIATION: technetium Tc 99m sulfur colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns
Status: COMPLETED
Conditions: Neonatal Jaundice|Hyperbilirubinemia
Interventions: DEVICE: Transcutaneous bilirubin screening|OTHER: Standard care (Visual inspection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Technology-assisted Collaborative Care Program for Depressed Patients With Chronic Disease at Primary Care
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: "Me cuido y me siento mejor"|BEHAVIORAL: Enhanced Usual Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Morphine on Dyspnea and 6-Minute Walk Distance in Pulmonary Arterial Hypertension
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-Drug Combination Chemotherapy Compared With Four-Drug Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: methotrexate|DRUG: paclitaxel|DRUG: vinblastine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Assess Pharmacokinetics, Safety, and Tolerability of MT-7117 in Subjects With Normal and Impaired Hepatic Function
Status: COMPLETED
Conditions: Mild and Moderate Hepatic Impairment
Interventions: DRUG: MT-7117
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Immunogenicity of 1 Dose of GSK134612 in Children 12-14 Months and 3-5 Years Old
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Conjugated meningococcal ACWY-TT (vaccine)|BIOLOGICAL: DTPa-IPV/Hib vaccine (Infanrix™-IPV/Hib)|BIOLOGICAL: DTPa-HBV-IPV/Hib vaccine (Infanrix hexa™)|BIOLOGICAL: Meningitec™|BIOLOGICAL: Mencevax™ACWY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Pitavastatin in Patient With a Metabolic Syndrome
Status: COMPLETED
Conditions: Hypercholesterolemia|Metabolic Syndrome
Interventions: DRUG: pitavastatin|BEHAVIORAL: Lifestyle Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High-dose Coenzyme Q10 on Biomarkers of Oxidative Damage and Clinical Outcome in Parkinson Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: coenzyme q10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3 Limus Agent Eluting Stents With Different Polymer Coating
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DEVICE: biodegradable polymer Rapamycin-eluting stent|DEVICE: permanent polymer rapamycin-eluting stent (Cypher)|DEVICE: permanent polymer everolimus-eluting stent (Xience, Promus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes"
Status: COMPLETED
Conditions: Achilles Tendinopathy
Interventions: DRUG: etoricoxib|DRUG: diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Clinical Telesurgery Using Chinese Independently Developed Surgical Robot System
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Bladder Cancer|Adrenal Tumor
Interventions: PROCEDURE: adrenalectomy for adrenal adenoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Avastin + Erbitux + Irinotecan as 2nd Line Treatment of Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Irinotecan|DRUG: Avastin|DRUG: Erbitux
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis (PBC)
Status: COMPLETED
Conditions: Fatigue|Primary Biliary Cirrhosis
Interventions: DRUG: Modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study Investigating the Effect of Rifabutin on the Pharmacokinetics of Maraviroc
Status: COMPLETED
Conditions: HIV Infection|HIV-1 Infection|Mycobacterium Avium Complex (MAC)
Interventions: DRUG: Rifabutin|DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 3TMPO (Triple-Tracer Strategy Against Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DIAGNOSTIC_TEST: FDG Positron emission tomography (PET) scan|DIAGNOSTIC_TEST: PSMA Positron emission tomography (PET) scan|DIAGNOSTIC_TEST: OCTREOTATE Positron emission tomography (PET) scan|OTHER: Optional Bone or soft-tissue biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Losartan Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibody Response to Human Papillomavirus Recombinant Vaccine (Gardasil®) in Girls and Young Women With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Gardasil® Vaccine (FDA-approved vaccination regimen)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Gemcitabine/Abraxane Chemotherapy and Dose Escalated Radiotherapy for Locally Advanced, Unresectable Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Abraxane|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Clinical Trial of DW340 and DW330SR + DW1030 Co-administration in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: combination drug: DW330SR, DW1030|DRUG: DW340
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Infant Malnutrition With Early Supplementation
Status: COMPLETED
Conditions: Underweight|Wasting|Stunting|Breastfeeding|Microbial Colonization
Interventions: OTHER: ESVS|OTHER: Exclusive breastfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 10 Years Follow-up Study of Plantar Pressure, Kinetics and Kinematics in a Cohort of Patients Diagnosed With Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetic Foot|Plantar Ulcer|Neuropathy|Gait Disorder, Sensorimotor|Motor Neuropathy|Foot Deformities|Foot Ulcer
Interventions: DEVICE: Prefabricated insoles|DEVICE: Soft custom-made insoles|DEVICE: Hard custom-made insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Meloxicam 15 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Meloxicam 15 mg Tablets|DRUG: Mobic® 15 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Outcomes of Frozen Shoulder Treated With Small Needle-Knife Through Microcirculation and Pulse Analysis.
Status: NOT_YET_RECRUITING
Conditions: Frozen Shoulder
Interventions: PROCEDURE: Small Needle-Knife|OTHER: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasted Bioequivalence Study of 2 Olanzapine Film-coated Tablets, 5 mg, in Healthy, Adult Male and Female Subjects.
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Olanzapine film-coated tablets 5 mg (JSC Farmak, Ukraine)|DRUG: Zyprexa® coated tablets 5 mg (Eli Lilly, Nederland B V)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Physiological Responses in Young and Older Adults During a Prolonged Simulated Heatwave
Status: COMPLETED
Conditions: Aging|Heat Stress|Physiological Stress
Interventions: OTHER: Simulated heatwave exposure|OTHER: Simulated heatwave exposure with mid-day cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: OT-101 in Combination With Pembrolizumab in Subjects With Malignant Pleural Mesothelioma Failing to Respond to Checkpoint Inhibition
Status: NOT_YET_RECRUITING
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: OT-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lapaquistat Acetate and Atorvastatin on Blood Cholesterol Levels in Subjects With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Lapaquistat acetate and atorvastatin|DRUG: Lapaquistat acetate and atorvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PrEP iT! Mobile App Intervention
Status: COMPLETED
Conditions: Treatment Adherence and Compliance
Interventions: BEHAVIORAL: PrEP iT! (plus usual PrEP care)|BEHAVIORAL: Usual PrEP care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Pharmacological Anti-lipolysis on FFA and VLDL-TG Metabolism Before and During Exercise
Status: COMPLETED
Conditions: Diabetes|Obesity
Interventions: DRUG: Acipimox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Validation of a Prognostic Score for Good Visual Recovery at One Year Following Combined Surgery for Cataract and Idiopathic Epiretinal Membrane
Status: RECRUITING
Conditions: Surgery for Cataract|Surgery for and Idiopathic Epiretinal Membrane
Interventions: OTHER: measurement of visual acuity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ExpressGraft-C9T1 Skin Tissue as a Treatment of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetes|Diabetic Foot Ulcer|Non-healing Wound
Interventions: BIOLOGICAL: ExpressGraft-C9T1 Skin Tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)
Status: COMPLETED
Conditions: Postoperative Wound Infection Deep Incisional Surgical Site|Prosthesis and Implants|Surgical Site Infection|Prosthetic Joint Infection
Interventions: OTHER: Photodynamic Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Eribulin With Gemcitabine in Patients With Advanced Liposarcoma or Leiomyosarcoma
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: Eribulin, gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: Placebo|DRUG: Belimumab 1 mg/kg|DRUG: Belimumab 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Dosage and Safety of Two Intramuscular Injections of an Investigational Clade B HIV Vaccine
Status: COMPLETED
Conditions: HIV
Interventions: BIOLOGICAL: Investigational HIV vaccine dose A|BIOLOGICAL: Investigational HIV vaccine dose B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Repaired Tetralogy of Fallot: Risc Score From MRI & Clinical Data to Predict the Need for Change of Treatment
Status: NOT_YET_RECRUITING
Conditions: Tetralogy of Fallot|Congenital Heart Disease
Interventions: DIAGNOSTIC_TEST: cardiac MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Apatinib With Pembrolizumab in Previously Treated Advanced Malignancies
Status: TERMINATED
Conditions: Advanced Malignancies|Urothelial Carcinoma|MSI-H or dMMR Solid Tumors|Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
Interventions: DRUG: Apatinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vapocoolant (Pain Ease) Use for Venipuncture
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: Vapocoolant (Pain Ease)|DEVICE: Nature's Tears Sterile Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Microcirculatory and Bioresorbable Vascular Scaffolds
Status: COMPLETED
Conditions: CHD - Coronary Heart Disease|Angina, Stable|Myocardial Ischemia
Interventions: DEVICE: Bioresorbable Vascular Scaffolds (BVS)|DEVICE: Drug-Eluting Stent (DES) - slow|DEVICE: Drug-Eluting Stent (DES) - standard(std)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple-ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD9977|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sensory Habituation in Autism Spectrum Disorders
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Autism|Sensory Processing Disorder|Sensory Over-Responsivity
Interventions: BEHAVIORAL: Sensory Habituation Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Digital-based Physical Activity Intervention in Individuals With Knee Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Digital-based physical activity intervention|OTHER: Patient education and exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine, Lenalidomide (Revlimid®) and Dexamethasone (BRd) as 2nd-line Therapy for Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proton Based Cardiac Sparing Accelerated Fractionated RadioTherapy in Unresectable NSCLC
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Durvalumab|RADIATION: Proton beam therapy RT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Open-Label Extension Trial for Subjects Completing the Phase 3 Trial of Fesoterodine (SP584) for the Treatment of Overactive Bladder Syndrome
Status: COMPLETED
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: SPM 907
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest
Status: COMPLETED
Conditions: Out-Of-Hospital Cardiac Arrest|Cardiac Arrest|Cardiac Arrest With Successful Resuscitation|Post Cardiac Arrest Syndrome|Systemic Inflammatory Response Syndrome|Neurological Injury
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Interference Between Oral Anticoagulants and Heparin During Ablation of Atrial Fibrillation (AF) or Left Atrial Tachycardia (GAD) by Catheter.
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Tachycardia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Equivalence of Monitoring by a Nurse Practitioner for Patients With Digestive Cancer
Status: UNKNOWN
Conditions: ColoRectal Cancer
Interventions: DRUG: standard chemotherapy for colorectal cancer|OTHER: Nurse practitioner consultation|OTHER: Medical practitioner consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Transplant Conditioning Regimen for Severe Thalassemia
Status: COMPLETED
Conditions: Severe Thalassemia
Interventions: DRUG: Transplant conditioning regimen of alemtuzumab, fludarabine, and melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of PPCI on Diastolic Function & Levels of Galactin-3 in Patients With STEMI
Status: UNKNOWN
Conditions: STEMI - ST Elevation Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: 2D Echocardiography with color Doppler assessment & Galactin-3 level in blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease
Status: WITHDRAWN
Conditions: Heart Failure, Systolic|Renal Disease, End Stage|Chronic Kidney Diseases
Interventions: DRUG: Anakinra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Residual Extensor Lag Approximately 1 Month After Splint or Cast Immobilization of a Mallet Finger
Status: WITHDRAWN
Conditions: Patients Present With Mallet Finger
Interventions: OTHER: PROMIS Upper Extremity|OTHER: Likert Pain Scale|OTHER: Mallet Finger Extensor Lag Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus
Status: UNKNOWN
Conditions: Keratoconus|Post LASIK Keratectasia
Interventions: RADIATION: 0.1% Riboflavin ophthalmic solution (KXL System With vibeX Rapid)|PROCEDURE: simultaneous KXL and topography-guided transepithelial photorefractive keratectomy(PRK)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Surgical Site Treatment With Ropivacaine in Laparoscopic Surgery
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Topical use|OTHER: laparoscopic repair of inguinal hernia|OTHER: laparoscopic bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: UB-312 in Patients With Synucleinopathies
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple System Atrophy|Parkinson Disease
Interventions: BIOLOGICAL: UB-312 Injection|BIOLOGICAL: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prucalopride Versus Placebo in Gastroparesis
Status: TERMINATED
Conditions: Gastroparesis
Interventions: DRUG: prucalopride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Romosozumab Use to Build Skeletal Integrity
Status: RECRUITING
Conditions: Osteoporosis|Osteoporosis, Postmenopausal|Osteoporosis Fracture
Interventions: DRUG: Romosozumab|DRUG: Placebo|DRUG: Zoledronic acid|DIETARY_SUPPLEMENT: Calcium and Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NovoTTF Therapy in Treating Patients With Recurrent Glioblastoma Multiforme
Status: TERMINATED
Conditions: Glioblastoma|Brain Neoplasms
Interventions: DEVICE: NovoTTF-100A|PROCEDURE: Quality-of-life assessment|GENETIC: Laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions
Status: COMPLETED
Conditions: Coronary Artery Bypass|Atherosclerosis
Interventions: DEVICE: Xience V coronary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy of Continued Versus Interrupted Novel Oral Anti-coagulant at Time of Device Surgery in Patients With Moderate to High Risk of Arterial Thromboembolic Events
Status: COMPLETED
Conditions: Hematoma
Interventions: DRUG: Dabigatran|DRUG: Rivaroxaban|DRUG: Apixaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Effect of LEO 152020 on the Heart of Healthy People
Status: COMPLETED
Conditions: Healthy Volunteers|Cardiac Repolarisation
Interventions: DRUG: LEO 152020|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy for Outer Retinal Degenerations
Status: COMPLETED
Conditions: Age Related Macular Degeneration|Stargardt's Disease|Exudative Age-related Macular Degeneration
Interventions: PROCEDURE: injection of hESC-RPE in suspension|PROCEDURE: injection hESC-RPE seeded in a substrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pomegranate on Aging and Inflammation of the Skin
Status: COMPLETED
Conditions: Skin Photoaging, Inflammation and Skin Pathogenic Bacteria
Interventions: DIETARY_SUPPLEMENT: Pomegranate Extract|DIETARY_SUPPLEMENT: Pomegranate Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Bioactivity of Ipilimumab and Nivolumab Combination Prior to Liver Resection in Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Outcomes in Neonatal Abstinence Syndrome
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome|Neonatal Opioid Withdrawal
Interventions: DRUG: Neonatal Morphine Solution|DRUG: Methadone|DRUG: Phenobarbital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Efficacy and Safety Relative to Standard of Care in Patients With COVID-19 Pneumonia
Status: UNKNOWN
Conditions: COVID-19|Pneumonia
Interventions: DRUG: Standard of Care (SOC) + ANG-3777|DRUG: Standard Of Care (SOC) + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-963272 in Participants With Nonalcoholic Fatty Liver Disease
Status: TERMINATED
Conditions: Nonalcoholic Fatty Liver Disease
Interventions: DRUG: BMS-963272|OTHER: Placebo matching BMS-963272
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Low or High Phosphate Diet on Phosphate and Calcium Excretion in Healthy People
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Aging|Nutrient; Excess
Interventions: DIETARY_SUPPLEMENT: Phosphate supplemented diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of High Cut-off (HCO) Hemodialysis on Central Memory CD4+ T and Treg Cells in Patients With End-stage Kidney Disease
Status: UNKNOWN
Conditions: End-stage Kidney Disease|CD4 T Cells|Central Memory T Cells|Regulatory T Cells|Uremic Toxins
Interventions: DEVICE: Polyamide HD membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: MB-102-- single dose of 4 µmol/kg|DRUG: MB-102-- single dose of 130 mg|DRUG: MB-102-single dose of 130 mg or 2 doses of 130 mg 12 hours apart|DRUG: MB-102-- two doses of 130 mg 24 hours apart|DRUG: Iohexol|DEVICE: QuantumLeap|DEVICE: Radiance|DEVICE: Brilliance (1 or 2 sensors)|DEVICE: Brilliance (2-part sensor)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Decolonization to Reduce After-Surgery Events of Surgical Site Infection
Status: RECRUITING
Conditions: Surgical Site Infection
Interventions: DRUG: 4% Chlorhexidine Gluconate|DRUG: 2% Mupirocin|DRUG: Soap Without Antiseptic Properties (Placebo)|DRUG: Placebo Nasal Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Macitentan in the Treatment of Organ Rejection After Lung Transplantation
Status: WITHDRAWN
Conditions: Lung Transplant Rejection
Interventions: DRUG: macitentan|DRUG: placebo (for macitentan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Biocleanse Allografts For ACL Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: ACL reconstruction control|PROCEDURE: ACL Biocleanse, surgical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Intraocular Melanoma|Melanoma (Skin)
Interventions: BIOLOGICAL: MART-1 antigen|BIOLOGICAL: gp100:209-217(210M) peptide vaccine|BIOLOGICAL: therapeutic autologous dendritic cells|BIOLOGICAL: tyrosinase peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Thoracic Manipulation and Muscle Energy Technique in Non-specific Mechanical Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: thoracic Manipulation Posterior anterior and conventional therapy|OTHER: Muscle Energy Technique (PIR) and conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) With Atomoxetine in Young Adults and Its Effects on Functional Outcomes
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab (Avastin®) Versus Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema
Status: COMPLETED
Conditions: Diabetic Retinopathy|Macular Edema
Interventions: DRUG: bevacizumab|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chidamide Combined With Clad/Gem/Bu With AutoSCT in R/R Diffuse Large B Cell Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: Chidamide|DRUG: Cladribine|DRUG: gemcitabine|DRUG: Busulfan|PROCEDURE: Autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-based, Mobile Health (mHealth) Smoking Cessation Intervention in Vietnam
Status: RECRUITING
Conditions: Smoking Cessation|Mindfulness|Telemedicine|Smoking
Interventions: BEHAVIORAL: Mindfulness-based, smoking cessation focused text messages.|BEHAVIORAL: Educational messages|BEHAVIORAL: Control messages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Probiotic Lysate (Postbiotic and Metabiotic) Supplementation for Type 2 Diabetes Patients (DELI_Diab Study)
Status: COMPLETED
Conditions: Obesity|Obesity, Abdominal|Insulin Resistance|Insulin Sensitivity|Type2 Diabetes|Type 2 Diabetes Mellitus in Obese
Interventions: DIETARY_SUPPLEMENT: Probiotic lysate (postbiotic and metabiotic)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NPC Staged N2-3M0:Adjuvant Chemotherapy or Just Observation After Concurrent Chemoradiation
Status: TERMINATED
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Adjuvant chemotherapy with paclitaxel and nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reversal of Preneoplastic Metaplasia in the Stomach With MEK Inhibitor
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric Cancer|Metaplasia|Stage I Gastric Cancer|Initial-onset Gastric Cancer
Interventions: DRUG: Trametinib treatment|PROCEDURE: Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Upper Thoracic Manipulation on Skin Surface Temperature of T3 Vertebral Region and Biceps Brachii Muscle
Status: COMPLETED
Conditions: Myofascial Dysfunction
Interventions: OTHER: Spine manipulation|OTHER: Manipulation sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Sargramostim Plus Pembrolizumab With or Without Pemetrexed in Patients With Advance Non-small Cell Lung Cancer After Completion of Chemoimmunotherapy
Status: RECRUITING
Conditions: Advanced Lung Non-Small Cell Carcinoma|Non-Small Cell Carcinoma of Lung, TNM Stage 4
Interventions: DRUG: Granulocyte-Macrophage Colony-Stimulating Factor|DRUG: Pembrolizumab|DRUG: pemetrexed|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-needling Soreness After Internal Gastrocnemius Muscle Treatment
Status: COMPLETED
Conditions: Heel Pain Syndrome
Interventions: PROCEDURE: Dry needling treatment with a thinner needle|PROCEDURE: Dry needling treatment with a medium-sized needle|PROCEDURE: Dry needling treatment with a thickest needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT