pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Subjective Evaluation of a Sound Processing Method for Hearing Aids on Auditory Distance Perception
Status: COMPLETED
Conditions: Hearing Disorders|Hearing Loss, Sensorineural
Interventions: OTHER: Digital signal processing algorithms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Image-Guided Hypofractionated Radiation Therapy With Stereotactic Body Radiation Therapy Boost and Combination Chemotherapy in Treating Patients With Stage II-III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Large Cell Lung Cancer|Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIA Non-small Cell Lung Cancer|Stage IIB Non-small Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer
Interventions: RADIATION: hypofractionated radiation therapy|OTHER: laboratory biomarker analysis|RADIATION: image-guided radiation therapy|DRUG: carboplatin|DRUG: paclitaxel|RADIATION: stereotactic body radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of 200 IU OnabotulinumtoxinA (Botulinum Toxin Type A) in Patients With Idiopathic Overactive Bladder Resistant to Anticholinergic Treatment: A Retrospective Analysis
Status: COMPLETED
Conditions: Idiopathic Overactive Bladder Resistant to Anticholinergic Treatment
Interventions: PROCEDURE: Injection of onabotulinumtoxinA into the bladder wall
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Anastomotic Leak in Gastrointestinal (GI) Anastomosis With the Application of Tisseal in the Anastomotic Line
Status: UNKNOWN
Conditions: Anastomotic Leak
Interventions: DRUG: Fibrin glue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Stenosis
Interventions: DEVICE: SAPIEN 3 THV|BIOLOGICAL: Optimal Heart Failure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Potential Pharmacokinetic Kratom-oxycodone Interaction Concurrent With Clinical Endpoints
Status: RECRUITING
Conditions: Herbal Interaction
Interventions: DIETARY_SUPPLEMENT: Kratom|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect in the Short and Medium Term of Different Techniques of Tactile Stimulations on Neurological Development in a Population of Very Preterm Infants
Status: UNKNOWN
Conditions: Very Preterm Infant
Interventions: OTHER: massage with oil|OTHER: massage without oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Opioid Modulation and Neural Reward Activation in Healthy Adults
Status: COMPLETED
Conditions: Alcohol Drinking|Opioid Use, Unspecified
Interventions: DRUG: Naltrexone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications
Status: COMPLETED
Conditions: Ventilator-associated Pneumonia|Cardiac Arrests With Shockable Rhythm|Mild Therapeutic Hypothermia|Preventive Antibiotics
Interventions: DRUG: Amoxicillin - clavulanic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: rosiglitazone|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: GSK4381562|DRUG: Dostarlimab|DRUG: GSK4428859A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Tenalisib (RP6530) in Combination With Pembrolizumab in Relapsed or Refractory cHL
Status: TERMINATED
Conditions: Classical Hodgkin Lymphoma
Interventions: DRUG: Tenalisib|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isotretinoin, Interferon Alpha-2b, and Paclitaxel in Stage IV, Recurrent, or Persistent Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: recombinant interferon alpha-2b|DRUG: isotretinoin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Therapy for Anal Incontinence
Status: COMPLETED
Conditions: Anal Incontinence|Fecal Incontinence
Interventions: BEHAVIORAL: Eccentric Training|BEHAVIORAL: Concentric Training|BEHAVIORAL: Isometric Training|BEHAVIORAL: Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Adenoma Detection Rate With ENDOCUFF VISION® vs. G-EYE®
Status: COMPLETED
Conditions: Adenoma|Colorectal Cancer
Interventions: DEVICE: ENDOCUFF VISION® device|DEVICE: G-EYE® colonoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: PRGN-2009 in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Recurrent or Metastatic Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer|HPV-Related Carcinoma|HPV-Related Malignancy|Recurrent Cervical Carcinoma|Metastatic Cervical Cancer
Interventions: BIOLOGICAL: PRGN-2009 plus Pembrolizumab|DRUG: Pembrolizumab alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mepolizumab Treatment for Rhinovirus-induced Asthma Exacerbations
Status: UNKNOWN
Conditions: Asthma|Viral Infection
Interventions: DRUG: Mepolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-investigational Study to Evaluate Adenovirus Serotype 5 (Ad5) Neutralizing Antibodies (nAb) in Patients With Chronic Hepatitis B Virus (HBV) Mono-infection
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: OTHER: blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SCREENING
Clinical trial: Electrophysiological Study of Berrettini Anastomosis
Status: COMPLETED
Conditions: Electrophysiologic Study|Hand Anastomosis
Interventions: OTHER: electrophysiological study|DEVICE: electromyograph
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Pranayama Breathing Technique on Asthma Control, Pulmonary Function and Quality of Life
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Pranayama Breathing Technique|BEHAVIORAL: Relaxation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Nipocalimab in Reducing the Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
Status: RECRUITING
Conditions: Thrombocytopenia, Neonatal Alloimmune
Interventions: DRUG: Nipocalimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intracorporeal Versus Extracorporeal Technique for Ileocolic Anastomosis in Laparoscopic Right Hemicolectomy
Status: COMPLETED
Conditions: Complication of Gastrointestinal Anastomosis|Intestinal Anastomosis Complication
Interventions: PROCEDURE: intracorporeal ileocolic anastomosis|PROCEDURE: extracorporeal ileocolic anastomosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Transfacial Sutures Versus Stapler for Mesh Fixation in Laparoscopic Ventral Hernia Repair
Status: COMPLETED
Conditions: Ventral Hernia|Pain
Interventions: PROCEDURE: mesh fixation by transfacial sutures|PROCEDURE: mesh fixation by staples
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, SAD Study to Evaluate the Safety and Tolerability of LY03017
Status: NOT_YET_RECRUITING
Conditions: Hallucinations and Delusions Associated With Alzheimer's Disease Psychosis|Hallucinations and Delusions Associated With Parkinson Disease Psychosis|Negative Symptoms of Schizophrenia
Interventions: DRUG: LY03017|DRUG: LY03017-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Older Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAS Treatment - Opiate Versus Non-Opiate
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome
Interventions: DRUG: Morphine|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction
Status: UNKNOWN
Conditions: HOCM, Hypertrophic Obstructive Cardiomyopathy|LVOTO - Left Ventricular Outflow Tract Obstruction|Remodeling, Ventricular
Interventions: PROCEDURE: PTSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Cervical Cancer|Fallopian Tube Cancer|Head and Neck Cancer|Lung Cancer|Malignant Mesothelioma|Ovarian Cancer|Pancreatic Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: SS1(dsFv)-PE38 immunotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients
Status: RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer|Cancer Therapy-Related Cardiac Dysfunction|Cardiotoxicity|Heart Failure
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment
Status: COMPLETED
Conditions: Anemia|Pregnancy Complications
Interventions: DRUG: Ferli-6® (Continental Pharm co., ltd.)|DRUG: Venofer® (Vifor AG, St. Gallen, Switzerland)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Effect on Inflammation and Endothelial Function After Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction|Inflammation|Endothelial Dysfunction
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improving Perinatal Outcomes Among Kenyan Pregnant Women With an Integrated STI Testing Model
Status: NOT_YET_RECRUITING
Conditions: Hiv|Sexually Transmitted Infections (Not HIV or Hepatitis)
Interventions: DIAGNOSTIC_TEST: Xpert® CT/NG and TV testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preoperative Intravenous Iron Infusion to Reduce Post-surgical Complications: a Pilot Randomised Control Trial
Status: UNKNOWN
Conditions: Anemia|Major Abdominal Surgery|Pre-operative
Interventions: DRUG: Ferric carboxymaltose|DRUG: Ferrous Fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lixisenatide (AVE0010)|DRUG: Placebo|DEVICE: Pen auto-injector|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Study of GAM501 in the Treatment of Diabetic Ulcers of the Lower Extremities
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: BIOLOGICAL: GAM501|BIOLOGICAL: Placebo|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Incidence of Atrial Fibrillation in Patients With Severe Obstructive Sleep Apnea: The Reveal XT-SA Study
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Atrial Fibrillation
Interventions: DEVICE: Implantable Loop Recorder Insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Trivalent Influenza Vaccine (TIV) in Type 2 Diabetes Mellitus (T2DM) Patients With and Without Complications of Chronic Kidney Disease (CKD)
Status: COMPLETED
Conditions: Influenza|Vaccine Reaction|Diabetes Mellitus|Chronic Kidney Diseases
Interventions: DRUG: Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Occlusal Forces and Muscle Activity in Fixed Versus Removable Mandibular Implant Supported Overdenture
Status: COMPLETED
Conditions: Occlusion
Interventions: PROCEDURE: dental implants (K1 line conical connection double thread, OXY, Italy)|DEVICE: Occlusense (Bausch GmbH & Co. KG)|DEVICE: electromyography (EMG) (Nemus II)".|OTHER: oral health-related quality of life (OHRQoL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genomic Changes Associated With the Use of Intradermal Avotermin (Juvista) in Small Wounds in Healthy Male Subjects
Status: COMPLETED
Conditions: Cicatrix|Wound Healing
Interventions: DRUG: Intradermal avotermin|DRUG: Intradermal avotermin|DRUG: Placebo (vehicle)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Consumption of a Probiotic on the Load of S. Agalactiae.
Status: UNKNOWN
Conditions: Streptococcus Agalactiae
Interventions: BIOLOGICAL: Probiotic|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open-label, Single-arm, Multicenter Phase II Clinical Study： Evaluating RC48-ADC Combined With Triplizumab in the Neoadjuvant Treatment of Her2-positive Muscle-invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Neoadjuvant Treatment of Her2-positive Muscle-invasive Bladder Cance
Interventions: DRUG: RC48- ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Escalation Reduce Acute Myocardial Infarction Mortality in Cardiogenic Shock
Status: ENROLLING_BY_INVITATION
Conditions: Cardiogenic Shock|Acute Myocardial Infarction|STEMI - ST Elevation Myocardial Infarction|NSTEMI - Non-ST Segment Elevation MI|STEMI|NSTEMI|Acute Myocardial Infarction of Right Ventricle (Disorder)|Acute Myocardial Infarction of Left Ventricle|Acute Myocardial Infarction With ST Elevation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Assessment of the Occurrence of Hypothyroidism in Patients Treated With RAI for Hyperthyroidism.
Status: UNKNOWN
Conditions: Nodule Solitary Thyroid|Toxic Multinodular Goiter|Radioactive Iodine-Induced Hypothyroidism
Interventions: RADIATION: radioacive iodine therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of WZTL-002 CAR T-cells for Adults With Relapsed Large B-cell Lymphoma
Status: RECRUITING
Conditions: Large B-cell Lymphoma|Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Primary Mediastinal Large B-cell Lymphoma (PMBCL)|Transformed Non-Hodgkin Lymphoma
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: WZTL-002 CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Lapatinib or Trastuzumab in Treating Women With HER2/Neu-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: docetaxel|DRUG: lapatinib ditosylate|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing an Educational Intervention Program on Knowledge, Attitude and Behaviour Towards Pregnancy Prevention Based on Health Belief Model Amongst Adolescent Girls in Northern Ghana
Status: COMPLETED
Conditions: Adolescent Behavior
Interventions: BEHAVIORAL: comprehensive sex education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Status: RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Selinexor|DRUG: Selinexor|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment and Referral Versus Exercise in Primary Prevention of Falls: PA Healthy Steps Program
Status: COMPLETED
Conditions: Lower Extremity Weakness Distal|Distorted; Balance
Interventions: BEHAVIORAL: Assessment and education|BEHAVIORAL: Healthy Steps with Falls Case Management|BEHAVIORAL: Healthy Steps in Motion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Insulin Modulation of fMRI Connectivity in Healthy Adults
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: Insulin|OTHER: Taste Task|OTHER: Magnetic Resonance Imaging|DRUG: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DA-4505 as a Single Agent and in Combination With Pembrolizumab in Adult Patients With Locally Advanced or Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: DA-4505|DRUG: DA-4505 + Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Doripenem in CerebrospinalFluid After Doripenem Administration in Pediatric Patients Less Than 1 Year of Age
Status: TERMINATED
Conditions: Meningitis
Interventions: DRUG: Doripenem|DRUG: Doripenem
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Metoclopramide on Gastric Emptying in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Gastric Emptying|Mechanically Ventilation|Randomized Controlled Trial|Metoclopramide
Interventions: DRUG: Metoclopramide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Co-analgesic Effects of Dexamethasone and Pregabalin After Lumbar Slipped Disc Surgery
Status: COMPLETED
Conditions: Patients Undergoing a Lumbar Slipped Disc Surgery
Interventions: DRUG: Pregabaline (150mg), Dexamethasone (20mg/5ml; 0.2mg/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FCR Versus FC Alone in the Treatment of Chronic Lymphocytic Leukemia (CLL) in Relapsed Patients
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Rituximab|DRUG: Fludarabine Phosphate|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Managing Chronic Pain Through Self-Help
Status: COMPLETED
Conditions: Chronic Pain
Interventions: BEHAVIORAL: Self-help Acceptance and commitment therapy (Web-based)|BEHAVIORAL: Self-help Acceptance and commitment therapy (bibliotherapy)|OTHER: Self-help Education pamphlets on pain (active control group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety and Efficacy of a Novel Treatment, Keratinocyte Growth Factor (KGF), in Asthmatic Patients
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: Keratinocyte Growth factor|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients
Status: COMPLETED
Conditions: Pressure Ulcer|Spinal Cord Injuries
Interventions: PROCEDURE: Adhesive elastic taping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Various Doses of BCD-121 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BCD-121|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tecnis Eyhance Versus Rayner RayOne Study
Status: UNKNOWN
Conditions: Cataract Senile|Pseudophakia
Interventions: DEVICE: Intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fosfomycin i.v. for Treatment of Severely Infected Patients
Status: RECRUITING
Conditions: Bacterial Infections|Bone Diseases, Infectious|Osteomyelitis|Central Nervous System Bacterial Infections|Meningitis, Bacterial|Encephalitis|Brain Abscess|Urinary Tract Infections|Respiratory Tract Infections|Pneumonia, Bacterial|Skin Diseases, Bacterial|Soft Tissue Infections|Intraabdominal Infections|Sepsis|Bacteremia|Endocarditis, Bacterial
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Assessing Corneal Endothelial Cells in Patients With Neovascular Age-related Macular Degeneration Treated With the Port Delivery System With Ranibizumab (PDS)
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DEVICE: SUSVIMO Port Delivery System with ranibizumab (PDS)|DRUG: LUCENTIS (ranibizumab injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERAS in Pediatric & Adolescent Gynecology Preoperative Counseling
Status: RECRUITING
Conditions: Enhanced Recovery After Surgery|Gynecologic Disease
Interventions: OTHER: Enhanced Recovery After Surgery (ERAS) Counseling to Patients|OTHER: Enhanced Recovery After Surgery (ERAS) Counseling to Caregiver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Electrophysiological Investigation of Higher Level Neural Manifestations of Freezing of Gait in Parkinson's Disease Patient
Status: COMPLETED
Conditions: Parkinson's Disease|Freezing of Gait
Interventions: DEVICE: PK-16CH EXG system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Volemic Resuscitation in Sepsis and Septic Shock
Status: UNKNOWN
Conditions: Hemodynamic Instability|Sepsis|Septic Shock
Interventions: DEVICE: Flotrac/Ev1000|DEVICE: Standard ICU monitorisation|DEVICE: VolumeView/Ev1000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1358894 in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1358894|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation
Status: COMPLETED
Conditions: Out of Hospital Cardiac Arrest
Interventions: OTHER: NAD-CPR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Treatment of Hot Flushes Caused by Leuprorelin 11.25 mg in Prostate Adenocarcinoma
Status: COMPLETED
Conditions: Adenocarcinoma, Prostate
Interventions: DRUG: Cyproterone acetate|DRUG: Medroxyprogesterone acetate|DRUG: Venlafaxine|DRUG: Leuprorelin|DRUG: Flutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pigtail or Chest Tube Placement After Uniportal Video-assisted Thoracoscopic Surgery
Status: RECRUITING
Conditions: Post Operative Pain, Acute|Post-Op Complication|Opioid Use, Unspecified|ERAS|Uniportal Video-Assisted Thoracic Surgery (VATS)
Interventions: PROCEDURE: uniportal VATS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised, db, Placebo-controlled Study of BI 1356 for 18 Weeks Followed by a 34 Week Double-blind Extension Period (Placebo Patients Switched to Glimepiride) in Type 2 Diabetic Patients for Whom Treatment With Metformin is Inappropriate
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Linagliptin|DRUG: Linagliptin Placebo|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Intervention for the Children With Severe Speech Sounds Disorders
Status: UNKNOWN
Conditions: Speech Sound Disorder|Apraxia of Speech|Developmental Verbal Dyspraxia
Interventions: BEHAVIORAL: Treatment for Children with Severe Speech Sound Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise in Postconcussion Symptoms and Posttraumatic Headache
Status: RECRUITING
Conditions: Brain Concussion|Post-Concussion Syndrome|Post-Traumatic Headache|Craniocerebral Trauma
Interventions: OTHER: Sub-symptom threshold exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BOS161721 in Systemic Lupus Erythematosus (SLE) Patients on a Background of Limited Standard of Care
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: BOS161721|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preemptive Ethanol Lock Therapy in Pediatric Bloodstream Infection
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Blood Disorders|Solid Tumors
Interventions: DRUG: Ethanol lock therapy (ELT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intralesional Injection of Acyclovir Versus Candida Antigen in Treatment of Plantar Warts
Status: UNKNOWN
Conditions: Acyclovir and Candida Antigen in Treatment of Plantar Wart
Interventions: DRUG: Acyclovir 250mg Powder for Solution for Infusion, each vial contains 250mg of acyclovir as the sodium salt, Chandra Bhagat Pharma Pvt. Ltd andcandida antigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of [18F]MNI-952 as a Potential PET Radioligand for Imaging Tau Protein in the Brain
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy|Alzheimer Disease|Healthy Volunteers
Interventions: DRUG: [18F]MNI-952|DRUG: [18F]Florbetapir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of High Intensity Interval Training on Mechanisms of Neuroplasticity in Parkinson's Disease Patients
Status: UNKNOWN
Conditions: Parkinson's Disease|Physical Activity|Neurorehabilitation|Neuroplasticity
Interventions: BEHAVIORAL: high-intensity interval training (HIIT)|BEHAVIORAL: conventional physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin and Alcohol Withdrawal and Dependence
Status: COMPLETED
Conditions: Alcoholism|Substance-Related Disorders
Interventions: DRUG: intranasal oxytocin spray|OTHER: intranasal spray without oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical CBD for Musculoskeletal Pain
Status: WITHDRAWN
Conditions: Musculoskeletal Pain
Interventions: DRUG: CBD|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tailored vs. Anatomical Ablation Strategy for Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Dispersion ablation + PVI|DEVICE: VX1|PROCEDURE: PVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abelcet Radiotagging Protocol: Inhaled Lipid Complex Abelcet® in Lung Transplant Recipients
Status: TERMINATED
Conditions: Lung Transplantation|Lung Diseases
Interventions: DRUG: Amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PaRTNer: Patient Reported Outcomes and Financial Toxicity in Head and Neck Cancer A Pilot, Survey Based Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: OTHER: Demographics questionnaires and the FACT HN questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Prophet Trial -Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension
Interventions: DEVICE: Occlutech AFR Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Add on Aliskiren to Angiotensin Converting Enzyme Inhibitor (ACEI) and Angiotensin I Receptor Blocker (ARB) Treatment in Type 2 Diabetes With Nephropathy
Status: UNKNOWN
Conditions: Type 2 Diabetes With Nephropathy
Interventions: DRUG: Aliskiren 300mg/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Regorafenib-pembrolizumab vs. TACE/TARE in Intermediate Stage HCC Beyond Up-to-7
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Regorafenib in combination with pembrolizumab|PROCEDURE: Loco-regional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SCH 66336 Plus Gemcitabine in Treating Patients With Advanced Cancer of the Urinary Tract
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: lonafarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Stem Cell Therapy Combined With Psychological Therapy and Rehabilitation for Autism
Status: COMPLETED
Conditions: Stem Cell Transplantation
Interventions: BIOLOGICAL: Stem cell transplantation|BEHAVIORAL: Psychological therapy and Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of CS1 CAR-T (WS-CART-CS1) in Subjects With Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: WS-CART-CS1|DRUG: Lymphodepleting chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Oral Motor Stimulation And Nonnutritive Sucking To The Time Of Transition To Oral Nutrition In Preterm
Status: COMPLETED
Conditions: Preterm|Nutrition Disorder, Infant|Feeding; Difficult, Newborn
Interventions: OTHER: PIOMI and non-nutritive sucking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cannabidiol and Cannabis Concentrate Users
Status: RECRUITING
Conditions: Cannabis Use Disorder
Interventions: DRUG: Broad Spectrum Cannabidiol (bsCBD) 400 mg|DRUG: Broad Spectrum Cannabidiol (bsCBD) 200 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-61393215 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-61393215|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Functional MRI and DTI Analysis of Post VNS Therapy Rehab Changes
Status: COMPLETED
Conditions: Stroke Hemorrhagic
Interventions: PROCEDURE: fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Safety, Tolerability and Drug Levels of BMS-986172 in Healthy and Obese Participants, Including an Assessment of the Effects of Food on BMS-986172 Absorption
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986172|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety/Efficacy of Everolimus in Adults With Advanced Pancreatic Neuroendocrine Cancer Not Responsive to Chemotherapy
Status: COMPLETED
Conditions: Islet Cell Carcinoma|Neuroendocrine Carcinoma|Neuroendocrine Tumor|Pancreatic Neoplasms
Interventions: DRUG: Everolimus 10 mg|DRUG: Octreotide Depot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Monovalent mRNA Vaccine Encoding Influenza Hemagglutinin in Adult Participants 18 Years of Age and Older
Status: COMPLETED
Conditions: Influenza|Influenza Immunization
Interventions: BIOLOGICAL: Influenza Hemagglutinin mRNA vaccine|BIOLOGICAL: Quadrivalent Recombinant Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Amoxicillin and Cephalexin PK/PD in Neonates
Status: ENROLLING_BY_INVITATION
Conditions: Neonatal Infection
Interventions: DRUG: Amoxicillin|DRUG: Cephalexin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants
Status: COMPLETED
Conditions: Nephrocalcinosis
Interventions: DRUG: Alkaline citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Early Short-term Intravenous Iron Supplements Combined EPO in Preterm Infants
Status: COMPLETED
Conditions: Malnutrition
Interventions: OTHER: standard PN|DRUG: Vifor|DRUG: Vifor and EPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia|Human Papilloma Virus
Interventions: DEVICE: Local Hyperthermia at 37℃|DEVICE: LEEP or cold knife|DEVICE: Local Hyperthermia at 44℃
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic
Interventions: DRUG: Beraprost|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NAPS-MS: NAtalizumab Effects on Parameters of Sleep in Patients With Multiple Sclerosis Experiencing Fatigue or Sleepiness
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Natalizumab (Tysabri)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: Phentolamine Ophthalmic Solution 0.75%|DRUG: Pilocarpine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serum Metabolomics Study of Traditional Chinese Medicine Formula （Shen Qi Tiao Ti Formula） Intervention to Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Chinese Medicine Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aldosterone Antagonism in Diastolic Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure|Diastole
Interventions: DRUG: Eplerenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perfluorocarbon (ABL-101) Oxygenation for Stroke: Trial With GOLD (Glasgow Oxygen Level Dependent Technology) Imaging Theranostic
Status: UNKNOWN
Conditions: Acute Ischaemic Stroke
Interventions: DRUG: ABL-101|OTHER: 0.9% NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Optimization of Bioavailability From Iron Supplements: Study 2
Status: COMPLETED
Conditions: Iron Deficiency|Anemia|Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Single oral iron dose of 120 mg per day for 3 consecutive days|DIETARY_SUPPLEMENT: Two oral iron doses of 60 mg per day (morning + afternoon) for 3 consecutive days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Late LTP-like Plasticity Effects of tDCS in Subacute Stroke Patients
Status: UNKNOWN
Conditions: Stroke|Hemiparesis
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROGNOSTIC ROLE OF SERUM ALBUMIN LEVEL IN RADIOLOGICAL PROGRESSION OF GONARTHROSIS: IS IT A BIOMARKER IN ITSELF? A BIOMARKER ASSOCIATED WITH SYSTEMIC INFLAMMATION?
Status: COMPLETED
Conditions: Gonarthrosis|Serum Albumin Low
Interventions: OTHER: serum albumin level
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Pharmacokinetics (PK) and Safety of IV Carbamazepine Relative to Oral Carbamazepine in Adults With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Intravenous Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Study of ZPR Regimen in Relapsed/Refractory Diffuse Large B-cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Zanubrutinib, Polatuzumab vedotin and Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olanzapine Anorexia Cachexia
Status: UNKNOWN
Conditions: Anorexia
Interventions: DRUG: Olanzapine 5 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Compassionate Use of Omegaven in Children
Status: COMPLETED
Conditions: Total Parenteral Nutrition-induced Cholestasis|Cholestasis|Short Bowel Syndrome|Gastroschisis|Intestinal Atresia|Infant, Premature, Diseases|Cholestasis of Parenteral Nutrition
Interventions: DRUG: Omegaven
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Cabozantinib (XL184) Therapy in Castrate Resistant Prostate Cancer (CRPC) With Visceral Metastases
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xylitol for Chronic Sinusitis
Status: COMPLETED
Conditions: Chronic Rhinosinusitis|Rhinosinusitis|Sinusitis|Drain Sinus|Endoscopic Sinus Surgery|Biofilms|Bacterial Overgrowth
Interventions: DRUG: Xylitol|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparing Simultaneous and Consecutive Drainage of Bilateral Chronic Subdural Hematoma
Status: COMPLETED
Conditions: Subdural Hematoma, Chronic
Interventions: OTHER: Simultaneous burr hole craniostomy|OTHER: Consecutive burr hole craniostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Local Injection of Local Anesthetic 24 Hours After Knee Replacement Surgery May Decrease Pain for Several More Hours
Status: COMPLETED
Conditions: Arthroplasty, Knee|Pain
Interventions: DRUG: Bupivacaine|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninferiority Trial of MitraClip Implantation Strategies: 1 Clip vs. 2 Clips in Patients With Functional Mitral Regurgitation
Status: WITHDRAWN
Conditions: Mitral Regurgitation Functional
Interventions: DEVICE: MitraClip implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Oral Rinse for Xerostomia
Status: COMPLETED
Conditions: Xerostomia
Interventions: DEVICE: HYDRAL Oral Rinse|DEVICE: BIOTENE® Oral Rinse|DEVICE: Placebo Oral Rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT