pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Only Gonadotropin Vs. Letrozole Combined Gonadotropin Stimulation in IUI Cycles
Status: COMPLETED
Conditions: Infertility Unexplained
Interventions: DRUG: Letrozole 2.5mg|DRUG: Gonadotropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation
Status: COMPLETED
Conditions: Mechanical Ventilation Complication
Interventions: DRUG: propofol|DRUG: desflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmaceutical Collaborative Care Integrated to a Multidisciplinary Psychosocial Program
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: Psychosocial intervention|OTHER: Pharmaceutical care and psychosocial support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Docetaxel in Squamous Cell Carcinoma of the Head and Neck (TAX + Cisplatin in SCCHN)
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Four-Way Cross-Over Study To Compare The Plasma Concentrations Of PF-02413873 After Oral Administration Of Several Doses As Suspension And As Tablets.
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: 150 mg Suspension|DRUG: 30 mg Suspension|DRUG: 400 mg Suspension|DRUG: 5 mg Suspension|DRUG: 750 mg Suspension|DRUG: 150 mg Tablet|DRUG: 30 mg Tablet|DRUG: 400 mg Tablet|DRUG: 5 mg Tablet|DRUG: 750 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ph3 Study of Exemestane With or Without Entinostat in Chinese Patients With Hormone Receptor-Positive, Locally Advanced or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: Entinostat|DRUG: Placebo|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perceived Changes in Anxiety Symptom Burden During Treatment With Bryophyllum Pinnatum and Tolerability
Status: COMPLETED
Conditions: Anxiety Symptoms
Interventions: DRUG: Bryophyllum 50 % Chewing Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: Ebselen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of a Closed-loop System for the Treatment of Type 2 Diabetes at Home (DT2_2)
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2 - Insulin-Treated
Interventions: DEVICE: Closed-loop system|DEVICE: Open-loop system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Hypoparathyroidism|Endocrine System Diseases|Parathyroid Diseases
Interventions: COMBINATION_PRODUCT: eneboparatide|COMBINATION_PRODUCT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a Hydrogel, Applied Following Removal of Myomas During Gynecologic Surgery, Administered for the Prevention/Reduction of Postoperative Adhesion Formation
Status: COMPLETED
Conditions: Myoma
Interventions: OTHER: Adhibit Adhesion Prevention Gel|OTHER: Standard of Care Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of AVE0005 (VEGF Trap) in Patients With Chemoresistant Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Neoplasms|Cancer of the Ovary
Interventions: DRUG: Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)|DRUG: Aflibercept (ziv-aflibercept, AVE0005, VEGF trap, ZALTRAP®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-Post Intervention Study to Investigate the Safety, Feasibility, & Efficacy of the NeurGear ZenBud System for the Treatment of Anxiety & Anxiety-Related Symptoms
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Risperidone in Combination With Lorazepam Compared With Standard Therapy for Emergency Treatment of Schizophrenic Patients
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders|Emergency Treatment
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Probiotics in Reducing Duration and Symptoms of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: Probiotics (2 strains 10x10^9 UFC)|DIETARY_SUPPLEMENT: Placebo (potato starch and magnesium stearate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Videoconference Updates in Neonatal Intensive Care Unit on Parental Stress of Preterm Infants (VISIO-NEONAT)
Status: COMPLETED
Conditions: Preterm Infants|Parent-Child Relations|Parental Stress|Post Partum Depression|Neonatal Intensive Care Units|Videoconferencing
Interventions: OTHER: Videoconferencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure
Status: COMPLETED
Conditions: Raised Intraocular Pressure
Interventions: DRUG: AZD4017|DRUG: Placebo|DRUG: AZD4017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: LungVITamin D and OmegA-3 Trial (lungVITAL)
Status: ACTIVE_NOT_RECRUITING
Conditions: COPD|Asthma|Pulmonary Function|Pneumonia
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: fish oil|DIETARY_SUPPLEMENT: Vitamin D3 placebo|DIETARY_SUPPLEMENT: Fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients
Status: COMPLETED
Conditions: Pulmonary Hypertension|Mitral Regurgitation
Interventions: DRUG: inhaled milrinone|DRUG: intravenous milrinone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase ll Study of Pirfenidone in Patients With RAILD (TRAIL1)
Status: COMPLETED
Conditions: Rheumatoid Arthritis Interstitial Lung Disease
Interventions: DRUG: Pirfenidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NeoAdjuvant Therapy With Immunoreagent (SHR-1316) for Resectable Oesophageal Squamous Cell carciNoma
Status: UNKNOWN
Conditions: Oesophageal Squamous Cell Carcinoma
Interventions: DRUG: PD-L1 Antibody SHR-1316
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide, Rituximab, Gemcitabine, Oxaliplatin and Dexamethasone in Relapse and Refractory DLBCL
Status: UNKNOWN
Conditions: Diffuse Large B-cell Lymphoma Recurrent|Diffuse Large B Cell Lymphoma Refractory
Interventions: DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Dexamethasone|DRUG: Lenalidomide Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Observational Study for Determination of Minimal Clinically Important Difference of Allergic Rhinitis Symptoms Due to Grass Pollen (Equinoxe 2)
Status: COMPLETED
Conditions: Allergic Rhinitis Due to Grass Pollen
Interventions: OTHER: Allergic rhinitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Is There a Benefit to Optimize Heart Failure (HF) Treatment in Aged Over 80 Year's Old Patients?
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: - Angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decision Making Study in Young and Middle-Aged Adults: Part II
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: Dextroamphetamine|DRUG: Placebo|DIAGNOSTIC_TEST: [18F]Fallypride|DIAGNOSTIC_TEST: [18F]-FE-PE2I
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome
Status: TERMINATED
Conditions: Cushing Syndrome
Interventions: DRUG: ATR-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-interventional Study (NIS) on Sodium-glucose Co-transporter-2 Inhibitors (SGLT2i) Use in France
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Sodium/glucose cotransporter-2 inhibitors (SGLT2i)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: A Sequential Allocation Trial to Determine the Optimum Interval Time Between Boluses of a Fixed Volume of 2.5ml of Bupivacaine 0.25% Plus Fentanyl 8 mcg/ml
Status: COMPLETED
Conditions: Labor Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Parental Stress and Care Consumption Until 24 Months Corrected Age of Infants at a High Risk of Developmental Delay, After Discharge From Neonatal Intensive Care
Status: RECRUITING
Conditions: Cerebral Palsy
Interventions: OTHER: Parenting Stress Index (PSI)|OTHER: Collection of health care consumption|OTHER: Assessment of parent satisfaction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Weight Management Aimed to Reduce Risk and Improve Outcomes From Radical Prostatectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Prostate Cancer
Interventions: BEHAVIORAL: Weight Loss Program|BEHAVIORAL: Standardized educational flyer|BEHAVIORAL: Weight Maintenance Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multidetector Coronary CT In Vasospastic Angina
Status: UNKNOWN
Conditions: Vasospastic Angina
Interventions: PROCEDURE: Positive CAG with EG test|PROCEDURE: Negative CAG with EG test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Emotional Working Memory Training on Reducing Depressive Symptoms
Status: UNKNOWN
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Working memory training|BEHAVIORAL: Positive ABMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Visual Performance After Implantation of Multifocal Lens
Status: UNKNOWN
Conditions: Intraocular Lens
Interventions: PROCEDURE: trifocal lens|PROCEDURE: bifocal lens 1|PROCEDURE: bifocal lens 2|PROCEDURE: bifocal lens 3
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of the Fully Immersive VR Cognitive Training Based on Leisure Activities for the Elderly With MCI and SCD.
Status: UNKNOWN
Conditions: MCI|SCD|Virtual Reality
Interventions: BEHAVIORAL: VR cognitive training|BEHAVIORAL: Traditional cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Exercise Intervention to Improve Physical Function and Frailty in Multiple Myeloma Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: OTHER: Best Practice|OTHER: Exercise Intervention|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy Study of Fipamezole in Treatment of Motor Dysfunctions in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: fipamezole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Heart Trial
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Arteriosclerosis|Coronary Disease|Heart Diseases|Hypercholesterolemia|Hypertension|Myocardial Ischemia
Interventions: BEHAVIORAL: diet, vegetarianism|BEHAVIORAL: diet, fat-restricted|BEHAVIORAL: exercise|BEHAVIORAL: smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: Effects of 8 Week Plyometric Training on Physical Fitness and Technical Skills of Domestic Cricket Players
Status: COMPLETED
Conditions: Physical Fitness|Technical Skills
Interventions: OTHER: Plyometric Training|OTHER: Conventional Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Turmeric in Gingival Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Patient
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Tooth Brushing with Dentifrice|PROCEDURE: Turmeric Massaging|PROCEDURE: SRP with turmeric massaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia
Status: ENROLLING_BY_INVITATION
Conditions: Preeclampsia
Interventions: OTHER: H2S content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Peer Support Program in Cancer Patients Elkar Laguntza
Status: RECRUITING
Conditions: Neoplasms|Social Skills|Psychological Distress
Interventions: BEHAVIORAL: Peer support program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Saved From COVID-19 - Chloroquine (CQ) Prophylaxis for Health Care Workers at Risk for COVID
Status: TERMINATED
Conditions: COVID|Coronavirus Infection
Interventions: DRUG: Chloroquine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study Evaluating Efficacy of Pirepemat on Falls Frequency in Patients With Parkinson's Disease (PD)
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: Pirepemat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transdiagnostic Behavior Therapy vs TAU for Adjustment Disorder Following Traumatic Event Exposure
Status: NOT_YET_RECRUITING
Conditions: Adjustment Disorders|Mental Disorder
Interventions: BEHAVIORAL: Transdiagnostic Behavior Therapy (TBT)|BEHAVIORAL: Treatment as Usual-Problem Solving Therapy (TAU-PST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IO102 With Pembrolizumab, With or Without Chemotherapy, as First-line Treatment of Metastatic NSCLC
Status: COMPLETED
Conditions: NSCLC
Interventions: BIOLOGICAL: IO102|BIOLOGICAL: pembrolizumab (Keytruda)|DRUG: Carboplatin (Carboplatin Kabi)|DRUG: Pemetrexed (Pemetrexed Alvogen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Signal Switch Receptor Modified TIL for the Treatment of Advanced Gynecologic Tumors
Status: RECRUITING
Conditions: Advanced Gynecologic Tumors|Signal Switch Receptor Modified TIL|Treatment Side Effects|Effects of Immunotherapy
Interventions: BIOLOGICAL: Signal Switch Receptor Modified TIL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcome Measures in Myotonic Dystrophy Type 2
Status: COMPLETED
Conditions: Myotonic Dystrophy Type 2
Interventions: DIAGNOSTIC_TEST: DM1-ActivC|DIAGNOSTIC_TEST: R-PAct|DIAGNOSTIC_TEST: Beck depression inventory|DIAGNOSTIC_TEST: McGill pain questionnaire|DIAGNOSTIC_TEST: Brief Pain Inventory Short-Form|DIAGNOSTIC_TEST: Fatigue and Daytime Sleepiness Scale|DIAGNOSTIC_TEST: Myotonia Behaviour scale|DIAGNOSTIC_TEST: Hand opening time|DIAGNOSTIC_TEST: Pressure pain threshold|DIAGNOSTIC_TEST: Manual muscle testing|DIAGNOSTIC_TEST: Quantitative muscle testing|DIAGNOSTIC_TEST: Scale for Assessment and Rating of Ataxia|DIAGNOSTIC_TEST: Berg balance scale|DIAGNOSTIC_TEST: Quick motor function test|DIAGNOSTIC_TEST: GSGC|DIAGNOSTIC_TEST: 30 seconds sit to stand test|DIAGNOSTIC_TEST: Functional Index-2|DIAGNOSTIC_TEST: Six minute walking test|DIAGNOSTIC_TEST: Myotonia (from Individualised Neuromuscular Quality of Life Questionnaire)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Finding Study for a Botulinum Toxin Type A Injection to Treat Habitual Snoring
Status: TERMINATED
Conditions: Habitual Snoring
Interventions: DRUG: IncobotulinumtoxinA|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Progressive Relaxation Exercises and TENS on Women Delivering Via Cesarean
Status: COMPLETED
Conditions: Cesarean Section|Acute Pain
Interventions: DEVICE: Transcutaneous electrical neural stimulation (TENS)|OTHER: Progressive relaxation exercises (PRE)|OTHER: Transcutaneous electrical neural stimulation (TENS) and Progressive relaxation exercises (PRE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open-Label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis
Status: ACTIVE_NOT_RECRUITING
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: zilucoplan (RA101495)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Treatments Applied to Patients With Facial Myalgia on Occlusion Parameters
Status: COMPLETED
Conditions: Occlusion|Quality of Life
Interventions: DRUG: Etodolac 400 MG|DRUG: Thiocolchicoside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the WallFlex™ Biliary Fully-covered Stent for the Palliative Treatment of Malignant Bile Duct Obstruction
Status: COMPLETED
Conditions: Cholestasis, Extrahepatic
Interventions: DEVICE: WallFlex™ Biliary Fully Covered Metal Stent placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Sildenafil as a Therapy for Fatigue in Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer|Cholangiocarcinoma
Interventions: DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: IL-1ra Dose-range Study for Moderate-to-severe TBI Patients
Status: UNKNOWN
Conditions: Traumatic Brain INjury
Interventions: DRUG: Anakinra Prefilled Syringe|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous vs Conventional Radiofrequency Applications for the Treatment of Knee Osteoarthritic Pain
Status: RECRUITING
Conditions: Percutaneous|Conventional|Radiofrequency|Knee Osteoarthritis|Pain
Interventions: DEVICE: Percutaneous radiofrequency|DEVICE: Conventional radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone and Pemetrexed/Solid Tumors
Status: WITHDRAWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: Ixabepilone|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Penpulimab in Combination With Cetuximab as First-line Treatment in R/M SCCHN
Status: RECRUITING
Conditions: Head and Neck Neoplasms|Recurrent Disease|Metastatic Cancer
Interventions: DRUG: Penpulimab combined with cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Standard Dose and Reduced Dose Tacrolimus + Sirolimus + Corticosteroids in Renal Allograft Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Rapamune® (Sirolimus)|DRUG: Tacrolimus|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHF6467 SAD and MAD in Patients With Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Diabetic Neuropathic Foot Ulcers
Interventions: BIOLOGICAL: CHF6467 active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remotely Supervised tDCS for Slowing ALS Disease Progression
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: OTHER: Transcranial Direct Current Stimulation (tDCS)|OTHER: Sham tDCS + anodal tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can we Use a Simple Blood Test to Reduce Unnecessary Adverse Effects From Radiotherapy by Timely Identification of Radiotherapy-resistant Rectal Cancers? MeD-Seq Rectal Study
Status: NOT_YET_RECRUITING
Conditions: Pathological Response Rate, Circulating Tumour DNA
Interventions: DIAGNOSTIC_TEST: MeD-seq
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: placebo gel|DRUG: Aloevera|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation for Tissues Perfusion
Status: COMPLETED
Conditions: Renal Function Disorder|Critical Illness|Critical Illness Myopathy
Interventions: DEVICE: trans-cutaneous electrical nerve stimulation.|DEVICE: Sham TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Dose-response, Pharmacodynamic and Pharmacokinetic Bioequivalence of Filgrastim in Healthy Male Volunteers After Single and Multiple-dose Subcutaneous Administration of the Test Injectable Formulation BK0023 vs. Neupogen®
Status: COMPLETED
Conditions: Healthy Male Subjects
Interventions: DRUG: Filgrastim test|DRUG: Filgrastim reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nomacopan Therapy in Adult Patients With Bullous Pemphigoid Receiving Adjunct Oral Corticosteroid Therapy (ARREST-BP)
Status: WITHDRAWN
Conditions: Bullous Pemphigoid
Interventions: DRUG: nomacopan (rVA576)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Pilot Study Comparing Cost Effectiveness on Two Commercially Available Gastric Feeding Tubes
Status: TERMINATED
Conditions: Long Term Enteral Tube Feeding
Interventions: DEVICE: Capsule Dome G-Tube|DEVICE: Balloon Bolus feeding tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Ascending, Single Oral Dose Pharmacokinetic Study of 3'-Deoxy-3'-Fluorothymidine (FLT) in Asymptomatic Human Immunodeficiency Virus (HIV)-Infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Alovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cohort Study - SBRT for VT Radioablation
Status: RECRUITING
Conditions: Ventricular Tachycardia|Myocardial Infarction|Heart Disease Structural Disorder
Interventions: RADIATION: Stereotactic Body Radiotherapy (SBRT) ablation of VT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Value of Lentils and Chickpeas
Status: COMPLETED
Conditions: Healthy Adults
Interventions: OTHER: Control Diet|OTHER: Lentil Containing Diet|OTHER: Chickpea Containing Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ocular Signs and Symptoms in Glaucoma Patients Switched From Latanoprost to Preservative Free Tafluprost Eye Drops
Status: COMPLETED
Conditions: Ocular Hypertension|Open-Angle Glaucoma
Interventions: DRUG: tafluprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Vaccine (PDS0101) and Chemoradiation for the Treatment of Stage IB3-IVA Cervical Cancer, the IMMUNOCERV Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Stage IB3 Cervical Cancer FIGO 2018|Stage II Cervical Cancer FIGO 2018|Stage IIA Cervical Cancer FIGO 2018|Stage IIA1 Cervical Cancer FIGO 2018|Stage IIA2 Cervical Cancer FIGO 2018|Stage IIB Cervical Cancer FIGO 2018|Stage III Cervical Cancer FIGO 2018|Stage IIIA Cervical Cancer FIGO 2018|Stage IIIB Cervical Cancer FIGO 2018|Stage IIIC Cervical Cancer FIGO 2018|Stage IIIC1 Cervical Cancer FIGO 2018|Stage IIIC2 Cervical Cancer FIGO 2018|Stage IVA Cervical Cancer FIGO 2018
Interventions: DRUG: Cisplatin|BIOLOGICAL: Liposomal HPV-16 E6/E7 Multipeptide Vaccine PDS0101|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients
Status: COMPLETED
Conditions: Hip Fracture
Interventions: PROCEDURE: UFNB (Ultrasound guided femoral nerve block)|PROCEDURE: UFIB (Ultrasound Guided Fascia Iliaca Compartment Block)|DRUG: IVMS (IV Morphine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REDWIL: Reduction of Wound Infections in Laparoscopic Colon Resections by Wound Protectors
Status: COMPLETED
Conditions: Colorectal Surgery|Wound Infections
Interventions: DEVICE: wound protector|DEVICE: no wound protector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of an Adult Acute Lymphoblastic Leukemia Chemotherapy for Adult Lymphoblastic Lymphoma
Status: UNKNOWN
Conditions: Lymphoblastic Lymphoma
Interventions: DRUG: Prednisone, vincristine, daunorubicin , cyclophosphamide , L.-asparaginase, cytosine-arabinoside, methotrexate, etoposide|PROCEDURE: hematopoietic stem cell allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Tracheal Intubation vs Laryngeal Mask Airway in Laparoscopic Total Extraperitoneal Hernia Repair
Status: COMPLETED
Conditions: Lung Functions|Pain Score
Interventions: PROCEDURE: Tracheal intubation in laparoscopic extraperitoneal hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial of TTA-121 on Autism Spectrum Disorder
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: DRUG: TTA-121
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of BCG Vaccine in the Clinical Evolution of COVID-19 and in the Efficacy of Anti-SARS-CoV-2 Vaccines
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: BCG (Bacillus Calmette-Guérin) vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Management of Gestational Diabetes in Obese Pregnant Women
Status: TERMINATED
Conditions: Diabetes, Gestational|Dietary Modification|Tissue Glucose|Body Composition|Birth Weight
Interventions: OTHER: Carbohydrate restricted diet|OTHER: Plant-protein based diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Non-Squamous Non-Small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|DRUG: Sitravatinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma
Status: TERMINATED
Conditions: Melasma
Interventions: DRUG: Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%|DRUG: Cetaphil® Moisturizing Cream as Inactive Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Decitabine + Modified BUCY Conditioning Regimen for High Risk Acute Myeloid Leukemia Undergoing Allo-HSCT
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Allogeneic Hematopoietic Stem Cell Transplantation|Conditioning
Interventions: DRUG: Decitabine plus Modified BUCY|DRUG: Modified BUCY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Meningococcal Conjugate Vaccine Given Concomitantly With Other Vaccines in Toddlers
Status: COMPLETED
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: MenACYW conjugate vaccine|BIOLOGICAL: MMR|BIOLOGICAL: Varicella|BIOLOGICAL: DTaP-IPV-HB-Hib|BIOLOGICAL: PCV13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Natural History Study of Patients With HPDL Mutations
Status: RECRUITING
Conditions: Mitochondrial Encephalomyopathies|Hereditary Spastic Paraplegia|Spastic Paraplegia|White Matter Disease|Neonatal Encephalopathy|Mutation|Genetic Disease
Interventions: OTHER: Patient Registry|OTHER: Dry blood spots sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of a Series of Systemic Cryotherapy Treatments on the Functional State of Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis (ICD10-G35)|Surface Electromyography|Whole-body Cryotherapy
Interventions: OTHER: Whole body cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: This Phase II/III, Multicenter Study is Designed to Evaluate the Safety and Clinical Activity of AL3810 in Patients
Status: UNKNOWN
Conditions: Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: AL3810|DRUG: carboplatin + etoposide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study Comparing the Mifne Approach of Treating Childhood Autism With Routine Standard Treatment
Status: TERMINATED
Conditions: Child Development Disorders, Pervasive
Interventions: BEHAVIORAL: Mifne Approach to PDD|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With MK6592 and an Anti-cancer Drug in Patients With Advanced Solid Tumors (6592-001)
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: DRUG: MK6592|DRUG: comparator: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Clinical Study of rTMS for Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: OTHER: Routine treatment in Neurology|DEVICE: Routine treatment in Neurology and rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Gemcitabine v. Gemcitabine Plus Docetaxel in Unresectable Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: Gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chinese Herbal Medicine for Immune Reconstitution Following HSCT in Acute Leukemia Patients
Status: COMPLETED
Conditions: Acute Leukemia
Interventions: DIETARY_SUPPLEMENT: Sheng-Yu-Tang
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sentinel Lymph Node Biopsy Versus Pelvic Lymphadenectomy in Early-stage Cervical Cancer (PHENIX/CSEM 010)
Status: UNKNOWN
Conditions: Cervical Cancer|Surgery|Quality of Life
Interventions: PROCEDURE: no systematic pelvic lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 68Ga-NY104 PET/CT in Patients With Metastatic Clear Cell Renal Cell Carcinoma
Status: RECRUITING
Conditions: Metastatic Clear Cell Renal Cell Carcinoma
Interventions: DIAGNOSTIC_TEST: 68Ga-NY104 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mechanisms of Sleep Latency and Health: The Effect of a Melatonin Receptor Agonist in Inflammation and Insulin Resistance
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: ramelteon|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Analgesic Efficacy of the Erector Spina Plane Block and Quadratus Lumborum Block in Open Nephrectomy: a Prospective Randomized Clinical Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: preoperative remifentanil consumption|PROCEDURE: postopeartive controlled anlagesia with morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Open, Pharmacokinetic Study of Caspofungin Acetate in Immunocompromised Young Children With Febrile Neutropenia (0991-042)
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: caspofungin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Pharmacokinetics, Safety & Tolerability of Aripiprazole in Adults With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Robotic and Laparoscopic Total Gastrectomy With D2 Lymphadenectomy for Locally Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: PROCEDURE: Robotic-assisted Total Gastrectomy|PROCEDURE: Laparoscopic-assisted Total Gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improvement of Hemostasis Techniques After Median Sternotomy
Status: UNKNOWN
Conditions: Sternal Dehiscence|Sternal Infection|Sternal Pain
Interventions: DEVICE: Ostene|DEVICE: Bonewax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GlideScope®Video Laryngoscope for Difficult Intubation: Implication of the Size of Blade
Status: COMPLETED
Conditions: Intubation; Difficult
Interventions: DEVICE: Macintosh laryngoscope|DEVICE: GVL selected by weight|DEVICE: smaller sized GVL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Locally Advanced Solid Tumors|Metastatic Solid Tumors
Interventions: DRUG: RX108
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determinants, Impact and Adherence Related to the Duration of Performing Self Catheterization on Patient Satisfaction and Quality of Life
Status: COMPLETED
Conditions: Intermittent Urethral Catheterization|Lower Urinary Tract Symptoms|Treatment Adherence|Patient Satisfaction
Interventions: OTHER: Observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Donor Cellular Therapy After Cytarabine in Treating Patients With Intermediate-Risk Acute Myeloid Leukemia in Remission
Status: WITHDRAWN
Conditions: Adult Acute Myeloid Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission
Interventions: DRUG: Cytarabine|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Peripheral Blood Stem Cell Transplantation|BIOLOGICAL: Therapeutic Allogeneic Lymphocytes|BIOLOGICAL: G-CSF mobilized peripheral blood cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1
Status: COMPLETED
Conditions: Smoking Cessation|Tobacco Use Disorder
Interventions: DRUG: Nicotine Replacement Therapies|DRUG: Nicotine patch|DIETARY_SUPPLEMENT: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating SHEN26 Capsule in Patients With Mild to Moderate COVID-19
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: SHEN26 capsule|DRUG: SHEN26 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma
Status: RECRUITING
Conditions: Advanced Dedifferentiated Liposarcoma|Locally Advanced Dedifferentiated Liposarcoma|Metastatic Dedifferentiated Liposarcoma|Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Unresectable Dedifferentiated Liposarcoma
Interventions: DRUG: Palbociclib|BIOLOGICAL: Cemiplimab|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Computed Tomography|PROCEDURE: Biospecimen collection|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)
Status: UNKNOWN
Conditions: Vitreoretinal Surgeries|Postoperative Nausea and Vomiting|Postoperative Pain|Oculocardiac Reflex
Interventions: DRUG: paracetamol|DRUG: 0,5 % bupivacaine with of 2% lidocaine|DRUG: 1 % ropivacaine with of 2% lidocaine|DRUG: 1 % Ropivacaine|DRUG: 0,5 % bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma
Status: RECRUITING
Conditions: Anaplastic Astrocytoma|Anaplastic Astrocytoma, Not Otherwise Specified|Anaplastic Ganglioglioma|Anaplastic Pleomorphic Xanthoastrocytoma|Glioblastoma|Malignant Glioma|WHO Grade 3 Glioma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Dabrafenib Mesylate|PROCEDURE: Lumbar Puncture|PROCEDURE: Magnetic Resonance Imaging|RADIATION: Radiation Therapy|DRUG: Trametinib Dimethyl Sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid Injection Post Arthroscopy - Does it Improve Immediate Function? Double Blind Controlled Prospective Study
Status: UNKNOWN
Conditions: Cartilage Injury
Interventions: DEVICE: Hyaluronic Acid Injection|DRUG: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism
Status: COMPLETED
Conditions: Primary Hyperaldosteronism
Interventions: DRUG: LCI699
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a
Status: COMPLETED
Conditions: Shigellosis
Interventions: BIOLOGICAL: Flexyn2a|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study to Assess WATCHMAN FLX™ Implants by Cardiac Computed Tomography, Magnetic Resonance Imaging and Transesophageal Echocardiography: WATCHMAN FLX™ CT
Status: ACTIVE_NOT_RECRUITING
Conditions: The Focus of the Study is to Reduce the Risk of Stroke and Life-threatening Bleeding Events in Patients With Non-valvular Atrial Fibrillation
Interventions: DEVICE: Watchman FLX Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD0585 Phase III Long-term Study in Japan
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: AZD0585|DRUG: AZD0585 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation of Elderly Patients With Frailty Syndrome Before Elective Surgery (PRAEP-GO)
Status: RECRUITING
Conditions: Frailty|Frail Elderly
Interventions: BEHAVIORAL: Prehabilitation- new form of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer.
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: capecitabine [Xeloda]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT