pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: Palovarotene|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disulfiram-Copper Gluconate in Met Pancreas Cancer w Rising CA19-9 on Abraxane-Gemzar, FOLFIRINOX or Gemcitabine
Status: TERMINATED
Conditions: Metastatic Pancreatic Cancer
Interventions: DIAGNOSTIC_TEST: Safety Laboratories|OTHER: AE Assessment|OTHER: Physical Exam|OTHER: Concomitant Medication Review|DIAGNOSTIC_TEST: Tumor Imaging|DRUG: nab-paclitaxel (Abraxane)/gemcitabine (Gemzar) Protocol Plus Disulfiram/Copper Gluconate|DRUG: FOLFIRINOX regimen Plus Disulfiram/Copper Gluconate|DRUG: Single-agent gemcitabine (Gemzar) regimen Plus Disulfiram/Copper Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis (EFEX-OA-01)
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Ergometer Cycling followed by treadmill running|OTHER: Treadmill Running followed by ergometer cycling|OTHER: Rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Whole Body Vibration Training Applied With Different Frequencies in Hypertensive Patients
Status: RECRUITING
Conditions: Hypertension
Interventions: OTHER: Whole body vibration intervention at 40 Hz|OTHER: Whole body vibration intervention at 25 Hz|OTHER: Whole body vibration intervention at 0 Hz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluoxetine Prevention Trial
Status: WITHDRAWN
Conditions: Cognitive Dysfunction
Interventions: DRUG: Fluoxetine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of Estramustine in Patient With Breast Cancer Progression After Treatment With Aromatase Inhibitor.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Estramustine|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Dapagliflozin|DRUG: Metformin|DRUG: Matching placebo to sitagliptin|DRUG: Matching placebo to dapagliflozin|DRUG: Sulfonylurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN)
Status: COMPLETED
Conditions: Herpes Zoster|Neuralgia|Pain|HIV Infections|Peripheral Nervous System Diseases
Interventions: DRUG: Capsaicin Dermal Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal
Status: COMPLETED
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: Pars plana vitrectomy and removal of epiretinal membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: EfiKroniK Research Program: Physical Exercise for People With Chronic Pathologies
Status: COMPLETED
Conditions: Neoplasms|Schizophrenia|COPD|Physical Activity|Quality of Life|Primary Care
Interventions: OTHER: Personalized Supervised physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantification of the Differences in the Diagnostic Relationships Between Centric Occlusion Versus Maximum Intercuspation in Adult Orthodontic Patients : A Cross-sectional Study
Status: RECRUITING
Conditions: Centric Relation Registration
Interventions: OTHER: centric relation registration|OTHER: maximum intercuspation registration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Trial to Test the Feasibility of Prolonged Fasting and Ketogenic Diet in Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis
Interventions: OTHER: Prolonged Fasting|OTHER: Ketogenic low glycemic load treatment|OTHER: Control diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eicosapentaenoic Acid (EPA) for Treatment of Colorectal Cancer Liver Metastases
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Eicosapentaenoic acid free fatty acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise to Reduce Obesity in Spinal Cord Injury
Status: COMPLETED
Conditions: Diabetes Mellitus|Obesity|Paraplegia|Quadriplegia|Spinal Cord Injury
Interventions: PROCEDURE: Arm Crank Ergometry|PROCEDURE: FES Cycle Ergometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Butyrate Enemas on Colonic Health
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Sodium butyrate|OTHER: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Safety and Effectiveness of Jobelyn in Pre-operative Management of Anaemia in Gynaecological Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Jobelyn|DRUG: Ferrous Sulphate + Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Immunogenicity of the Proposed Biosimilar Vedolizumab PB016 in Comparison With Entyvio®
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: BIOLOGICAL: Intravenous (IV) infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can PLIA Reduce Early Post-operative Pain After PAO Surgery?
Status: NOT_YET_RECRUITING
Conditions: Hip Dysplasia
Interventions: COMBINATION_PRODUCT: Ropivacaine, Epinephrine, Ketorolac, NaCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Two-Stage Tuberculin (PPD) Skin Testing in Individuals With Human Immunodeficiency Virus (HIV) Infection
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Tuberculin Purified Protein Derivative
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparative Evaluation of Minimally Invasive Nonsurgical Periodontal Therapy Versus Conventional Subgingival Instrumentation
Status: NOT_YET_RECRUITING
Conditions: Periodontitis|Subgingival Plaque
Interventions: PROCEDURE: Conventional Subgingival Instrumentation|PROCEDURE: minimally invasive non-surgical periodontal therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lidocaine Injection and Ischemic Compression on Chronic Pelvic Pain Treatment
Status: TERMINATED
Conditions: Pelvic Pain
Interventions: DRUG: lidocaine|PROCEDURE: Ischemic compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Chemical Therapy Induced Nausea and Vomiting: a Cross-over Trail
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: PROCEDURE: Manual acupuncture implemented by acupuncturist 1|PROCEDURE: Manual acupuncture implemented by acupuncturist 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PVP001, PVP002, and PVP003 in Healthy Adults and PVP001 and PVP002 in Adults With Celiac Disease
Status: COMPLETED
Conditions: Digestive System Disease
Interventions: OTHER: PvP001 placebo|DRUG: PvP001 100 mg|DRUG: PvP001 300 mg|DRUG: PvP001 900 mg|DRUG: Maximum Feasible Dose (MFD) of PvP002|DRUG: Maximum Tolerated Dose (MTD) of PvP001|DRUG: MTD of PvP001 following 7 days of PPI treatment|OTHER: PvP002 placebo|DRUG: PvP001 600 mg|DRUG: PvP003 placebo|DRUG: PvP003|DRUG: PvP003 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: African American Alzheimer's Progression Markers - CSF and Neuro-Imaging
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer's Disease
Interventions: PROCEDURE: Lumbar puncture|PROCEDURE: Blood draw|PROCEDURE: Magnetic Resonance Imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating Estradiol/Trimegestone in Vasomotor Symptoms (VMS) in Post-Menopausal Women.
Status: COMPLETED
Conditions: Postmenopause
Interventions: DRUG: Trimegestone|DRUG: 17b Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Durability of Protection and Immuno-persistence Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female
Status: RECRUITING
Conditions: Cervical Intraepithelial Neoplasia|Cervical Cancer|Vaginal Intraepithelial Neoplasia|Vulvar Intraepithelial Neoplasia|Persistent Infection
Interventions: BIOLOGICAL: Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of SEMG Biofeedback With Core Muscle Strengthening Exercises and Kinesiotaping on Diastasis Recti in Post-partum Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Diastasis Recti Abdominis
Interventions: DEVICE: Surface EMG Biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ovulation and Follicular Development Associated With Mid Follicular Phase Initiation of Combined Hormonal Contraception
Status: COMPLETED
Conditions: Ovulation Inhibition
Interventions: DRUG: Zoely|DRUG: Meliane ED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Transparent Elasticized Adhesive Occlusive Compression Bandage for Use as an Arterial Tourniquet
Status: COMPLETED
Conditions: Hemorrhage|Vascular Injury
Interventions: DEVICE: Pneumatic Tourniquet|DEVICE: One Windlass Tourniquet|DEVICE: Two Windlass Tourniquets|DEVICE: Tourniquet Tape 5 cm|DEVICE: Tourniquet Tape 10 cm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intense Therapeutic Ultrasound - Treatment for Chronic Plantar Fascia Musculoskeletal Pain Reduction
Status: COMPLETED
Conditions: Chronic Plantar Fasciitis
Interventions: DEVICE: Intense Therapeutic Ultrasound Treatment - ITU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Full-thickness Laparo-endoscopic Excision vs Laparoscopic Colectomy for Colonic Tumors
Status: UNKNOWN
Conditions: Colorectal Neoplasms, Benign
Interventions: PROCEDURE: full-thickness laparo-endoscopic colon adenomas excision|PROCEDURE: laparoscopic colon resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Causal Role of preSMA in Levodopa-induced Dyskinesia in Parkinson's Disease
Status: COMPLETED
Conditions: Dyskinesia, Drug-Induced|Parkinson Disease
Interventions: DEVICE: Repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Status: UNKNOWN
Conditions: Injuries, Spinal Cord|CVA (Cerebrovascular Accident)|Traumatic Brain Injury|MS (Multiple Sclerosis)|Muscle Spasticity|Cerebral Palsy, Spastic
Interventions: DEVICE: Prometra II Programmable Pump - Flowonix Medical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Diagnostic Efficacy and Safety of [123I]NAV5001 as an Imaging Agent to Aid in the Diagnosis of Parkinsonian Syndromes
Status: TERMINATED
Conditions: Parkinson's Syndrome
Interventions: DRUG: NAV5001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Avelumab and Cetuximab Plus Gemcitabine and Cisplatin in Participants With NSCLC
Status: COMPLETED
Conditions: Squamous Non-Small Cell Lung Cancer
Interventions: DRUG: Avelumab|DRUG: Cetuximab|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Systemic Mastocytosis|Aggressive Systemic Mastocytosis|Systemic Mastocytosis With an Associated Hematologic Neoplasm|Mast Cell Leukemia
Interventions: DRUG: Avapritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Offline Anosognosia For Spatial Neglect on Neglect Rehabilitation
Status: COMPLETED
Conditions: Hemispatial Neglect|Hemiplegia|Right Hemispheric Stroke|Anosognosia
Interventions: OTHER: Patient-tailored multimodal neglect rehabilitation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Digital Manipulation of Thyroid Cartilage and Fluency Shaping Therapy for the Management of Stuttering in Adult
Status: COMPLETED
Conditions: Developmental Stuttering
Interventions: BEHAVIORAL: Digital Manipulation of Thyroid cartilage|BEHAVIORAL: Fluency Shaping Therapy|BEHAVIORAL: combination Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Analgesic Efficacy of Serratus Anterior Plane Block and Intercostal Block
Status: COMPLETED
Conditions: Rib Fractures|Serratus Anterior Plane Block|Erector Spinae Plane Block|Acute Pain
Interventions: PROCEDURE: Serratus Anterior Plane Block|PROCEDURE: Intercostal Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Nerve Stimulation (TENS) for IUD Insertion Pain
Status: RECRUITING
Conditions: Pain
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Gardasil-9 and Cervarix
Status: COMPLETED
Conditions: HPV Vaccines Immunogenicity and Safety
Interventions: BIOLOGICAL: Immunogenicity two doses of Gardasil-9|BIOLOGICAL: Immunogenicity Cervarix and Gardasil-9
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Aliskiren When Added to Standardized Losartan and Optimal Antihypertensive Therapy in Patients With Hypertension, Type 2 Diabetes and Proteinuria
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of VX-407 in Healthy Participants
Status: RECRUITING
Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions: DRUG: VX-407|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Loss in Adults With Obesity Using a Combination of Low Energy Diet, Group Treatment and Intragastric Balloon
Status: UNKNOWN
Conditions: Obesity|Weight Loss|Non-Alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: Low energy diet using meal replacements|BEHAVIORAL: CBT-based group treatment|DEVICE: Intragastric balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Enterra Programming With Nocturnal Cycling in Gastroparetics
Status: RECRUITING
Conditions: Gastroparesis|Gastroparesis Nondiabetic|Gastroparesis Due to Diabetes Mellitus
Interventions: DEVICE: Enterra® Therapy System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-modality Imaging in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction|STEMI|Coronary Artery Disease|Atherosclerotic Plaque Disruption With Thrombosis of Artery
Interventions: PROCEDURE: Coronary Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety Study of ARRY-403 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: ARRY-403, glucokinase activator; oral|DRUG: Placebo; oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Food on the Pharmacokinetics of IN-A002 Capsule in Healthy Male Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: IN-A002(IN-115314) capsule|DRUG: IN-A002(IN-115314) capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Comparison of AmnioClear™ Human Allograft Amniotic Membrane vs. Moist Wound Dressing in the Treatment of Diabetic Wounds
Status: WITHDRAWN
Conditions: Diabetic Foot Ulcers|Wound Care
Interventions: BIOLOGICAL: AmnioClear™ Human Allograft Amniotic Membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Vitamin D on PFS in Indolent Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Follicular Lymphoma|Small Lymphocytic Lymphoma|Marginal Zone Lymphoma|Mucosal-Associated Lymphoid Tissue Lymphoma
Interventions: DIETARY_SUPPLEMENT: Vitamin D|BIOLOGICAL: Rituximab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study in Healthy Volunteers to Investigate the Effects of Quinidine on the Pharmacokinetics of NKTR-118
Status: COMPLETED
Conditions: Drug Induced Constipation
Interventions: DRUG: Nektar 118|DRUG: Quinidine|DRUG: Quinidine placebo|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Single and Multiple Escalating Dose Study of RGN1016 in Healthy Male Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: RGN1016|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacologic Optimization of Voriconazole
Status: COMPLETED
Conditions: Invasive Fungal Infection|Hematological Malignancy
Interventions: DRUG: voriconazole|DRUG: voriconazole (dosing according to the SPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of Vasovist® Magnetic Resonance Angiography (MRA) and an MRA With a Conventional Extracellular Contrast Agent With X-ray Angiography in Patients With Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Vascular Diseases
Interventions: DRUG: Vasovist (BAY86-5283, MS-325)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of the Mobile EEG-Neurofeedback in Healthy Child and Adolescent
Status: COMPLETED
Conditions: Internet Addiction
Interventions: DEVICE: mobile neurofeedback|DEVICE: sham mobile neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Postural Tachycardia Syndrome and Vasovagal Syncope in Relation to Serum Electrolytes and Adrenal Insufficiency
Status: RECRUITING
Conditions: POTS - Postural Orthostatic Tachycardia Syndrome
Interventions: DIAGNOSTIC_TEST: ECHO, Serum electrolytes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Haploidentical Hematopoietic Stem Cell Transplantation Patients With Wiskott-Aldrich Syndrome
Status: COMPLETED
Conditions: Wiskott-Aldrich Syndrome
Interventions: PROCEDURE: Hematopoietic stem cell transplantation|DEVICE: Miltenyi CliniMACS selection system|DRUG: Fludarabine, Melphalan, Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Cryoablation in Treating Patients With Painful Bone Metastases
Status: COMPLETED
Conditions: Metastatic Cancer|Pain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: questionnaire administration|PROCEDURE: cryosurgery|PROCEDURE: pain therapy|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Polycation-based New Dental Desensitizer on Dentin Hypersensitivity
Status: RECRUITING
Conditions: Dentin Sensitivity
Interventions: DEVICE: Polycation-based new dentinal desensitizer|DEVICE: GLUMA desensitizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Maitland Mobilization With Low Level Laser Therapy in Treatment of Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Low Level laser therapy|OTHER: Maitland mobilization technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Everolimus|DRUG: Exemestane|DRUG: Everolimus Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
Status: COMPLETED
Conditions: Physical Activity
Interventions: DRUG: Metformin|DRUG: Placebo|DIETARY_SUPPLEMENT: Carbohydrate Beverage|DIETARY_SUPPLEMENT: Protein Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Magnetic Resonance Imaging-guided Thermal Radiofrequencey Ablation of Primary Renal Cell Carcinoma, Hepatic Metastasis, and Other Sites of Solid Organ Tumor and Metastases
Status: COMPLETED
Conditions: Kidney Cancer|Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: PROCEDURE: radiofrequency ablation|PROCEDURE: thermal ablation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine and Bortezomib Combination Therapy in Indolent Non-Hodgkin's Lymphoma(NHL)
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Bendamustine|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An In-situ, Child-led Intervention To Promote Emotion Regulation Competence in Middle Childhood: Protocol For an Exploratory Randomised Control Trial
Status: UNKNOWN
Conditions: Emotions
Interventions: OTHER: Purrble|OTHER: Active control toy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Creative Drama on the Level of Mental Health Literacy
Status: NOT_YET_RECRUITING
Conditions: Nurse's Role|Mental Health Literacy|Education
Interventions: OTHER: mental health literacy training supported by creative drama|OTHER: mental health literacy training supported by classroom instruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate and Have Had Inadequate Response to Single TNF-alpha Antagonist
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: fostamatinib|DRUG: fostamatinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2a Study Evaluating AMG 232 in Metastatic Melanoma
Status: COMPLETED
Conditions: Advanced Malignancy|Advanced Solid Tumors|Cancer|Oncology|Oncology Patients|Tumors|Melanoma
Interventions: DRUG: AMG 232|DRUG: Trametinib|DRUG: Dabrafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of McGrath MAC®, Pentax-AWS® and Macintosh Direct Laryngoscopes for Nasotracheal Intubation
Status: COMPLETED
Conditions: Intubation;Difficult
Interventions: DEVICE: McGrath|DEVICE: Pentax|DEVICE: Macintosh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Vonorasan Versus Esomeprazole in the Treatment of Ulcers After Endoscopic Submucosal Dissection
Status: NOT_YET_RECRUITING
Conditions: Ulcers, Gastric
Interventions: DRUG: Vonoprazan|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin-Assisted Psychotherapy in Patients with Advanced Cancer on Maintenance Therapy
Status: RECRUITING
Conditions: Depression, Anxiety|Psilocybin-Assisted Psychotherapy|Advanced Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia
Status: TERMINATED
Conditions: Infant,Premature|Bronchopulmonary Dysplasia|Growth Failure
Interventions: DIETARY_SUPPLEMENT: Zinc Acetate|OTHER: No supplemental zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Imaging Study of Leukemia
Status: RECRUITING
Conditions: Acute Lymphocytic Leukemia|Acute Myeloid Leukemia|Ambiguous Lineage Leukemia or Lymphoma|Myeloma
Interventions: DRUG: FLT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Electromagnetic Field Therapy on Pain and Function in Patients With Mechanical Back Pain
Status: COMPLETED
Conditions: Mechanical Low Back Pain
Interventions: RADIATION: Pulsed electromagnetic field|OTHER: traditional physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Silicone Taping for the Improvement of Abdominal Donor Site Scars
Status: RECRUITING
Conditions: Hypertrophic Scar|Scar
Interventions: DEVICE: Silicone tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vismodegib in Treating Patients With Advanced Chondrosarcomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Clear Cell Chondrosarcoma|Dedifferentiated Chondrosarcoma|Locally Advanced Chondrosarcoma|Mesenchymal Chondrosarcoma|Metastatic Chondrosarcoma|Primary Central Chondrosarcoma|Unresectable Primary Central Chondrosarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacogenomic Study|DRUG: Vismodegib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptability, Feasibility, and Preliminary Impact of a Web-based, HIV Prevention Toolkit With Cisgender Male Couples in Lima, Peru
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections|Hiv|Sexually Transmitted Infections (Not HIV or Hepatitis)|Sexually Transmitted Diseases|Sexual Behavior|Risk Reduction
Interventions: BEHAVIORAL: Para ti, para mi, para nosotros (P3)|BEHAVIORAL: Waitlist Control Para ti, para mi, para nosotros (P3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy of Photodynamic Therapy in Basal Cell Carcinoma With 6 Months Follow-up
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: RADIATION: photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cystic Fibrosis and Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence|Cystic Fibrosis
Interventions: DEVICE: Reusable Underwear|DEVICE: Disposable urethral support|BEHAVIORAL: Pelvic floor physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RE-DEEM Dose Finding Study for Dabigatran Etexilate in Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DRUG: placebo|DRUG: dabigatran etexilate|DRUG: dabigatran etexilate|DRUG: dabigatran etexilate|DRUG: dabigatran etexilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Photodynamic Therapy vs. CO2 Laser Therapy in Treatment of Actinic Keratoses
Status: UNKNOWN
Conditions: Actinic Keratosis
Interventions: PROCEDURE: ablative CO2 laser therapy|PROCEDURE: photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Psychological Adjustment of Patients With LLA: a Multidisciplinary Rehabilitative Intervention Project
Status: RECRUITING
Conditions: Lower Limb Amputation|Prosthesis User
Interventions: DEVICE: Multidisciplinary Conventional and Technology-based Rehabilitation|OTHER: Multidisciplinary Conventional Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of 10XB-101 Injection in Adult Subjects With Submental Fat
Status: ACTIVE_NOT_RECRUITING
Conditions: Submental Fat
Interventions: DRUG: 10XB-101 Solution for Injection|DRUG: 10XB-101 Vehicle Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer
Status: RECRUITING
Conditions: Urinary Bladder Neoplasms|Receptors, Fibroblast Growth Factor
Interventions: DRUG: Erdafitinib Intravesical Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Prebiotics on Iron Absorption From High Dose Iron Supplements
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: ferrous fumarate|DIETARY_SUPPLEMENT: ferrous fumarate + 15 g GOS|DIETARY_SUPPLEMENT: ferrous fumarate + 15 g FOS|DIETARY_SUPPLEMENT: labelled iron as ferrous fumarate + 15 g acacia gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cast Sores With Waterproof Vs. Standard Cast Padding
Status: TERMINATED
Conditions: Pressure Ulcer
Interventions: OTHER: Casting using Gortex (waterproof) cast padding materials|OTHER: Casting using cotton/cotton-poly cast padding materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults
Status: COMPLETED
Conditions: Dengue Virus|Dengue Fever|Dengue Hemorrhagic Fever|Dengue Diseases
Interventions: BIOLOGICAL: Bivalent CYD-1,3 Dengue (Vero) + Bivalent CYD-2,4 Dengue (Vero)|BIOLOGICAL: Bivalent CYD-1,3 Dengue (Vero) + Bivalent CYD-2,4 Dengue (Vero)|BIOLOGICAL: Tetravalent blending VDV-2/CYD-1,3,4 Dengue (Vero)|BIOLOGICAL: Tetravalent CYD-1,2,3,4 Dengue (Vero)|BIOLOGICAL: JE-VAX®: Japanese encephalitis virus vaccine inactivated + Tetravalent CYD-1,2,3,4 Dengue (Vero)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients
Status: NOT_YET_RECRUITING
Conditions: Delirium
Interventions: DRUG: Clonidine|DRUG: SodiumChloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery
Status: RECRUITING
Conditions: Surgery, Cardiac|Tranxemic Acid|Activated Clotting Time|Heparin|Cardiopulmonary Bypass
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of AST-3424 in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors|Hepatocellular Carcinoma
Interventions: DRUG: AST-3424
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Osimertinib|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Placebo|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bupivacaine and Epinephrine Injection Study
Status: NOT_YET_RECRUITING
Conditions: Sinus Disease|Anesthesia|Bleeding
Interventions: DRUG: Sensorcaine with Epinephrine|OTHER: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobiology of Eating Disorders Treatments
Status: COMPLETED
Conditions: Anorexia Nervosa|Bulimia Nervosa
Interventions: BEHAVIORAL: CBT (Cognitive Behavioral Therapy)|OTHER: IBPP (individual psychology brief psychotherapy)|DRUG: CBT + OLANZAPINE|DIETARY_SUPPLEMENT: nutritional rehabilitation|DRUG: delorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laryngeal Masks in Urethral Cystoscopic Surgery Operations: a Prospective Randomized Clinical Study
Status: COMPLETED
Conditions: Ureteral Calculi
Interventions: DEVICE: proseal|DEVICE: baska-mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Immersive Virtual Reality-based Cognitive Remediation in Patients With Mood - or Psychosis Spectrum Disorders
Status: RECRUITING
Conditions: Bipolar Disorder|Depression|Psychotic Disorders|Cognitive Impairment|Schizophrenia|Schizotypal Disorder
Interventions: BEHAVIORAL: Virtual reality Based Cognitive Remediation|BEHAVIORAL: Virtual reality control training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tissue-Type Plasminogen Activator (t-PA) Release Predicts Major Adverse Cardiac Events (MACE) in Patients With Non-critical Coronary Artery Disease
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DRUG: Bradykinin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Efficacy of MK-8291 in Participants With Post-herpetic Neuralgia (PHN) With Allodynia (MK-8291-012)
Status: COMPLETED
Conditions: Postherpetic Neuralgia
Interventions: DRUG: MK-8291|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of 5 Years of Adjuvant Osimertinib in Completely Resected Epidermal Growth Factor Receptor Mutation (EGFRm) Non-small Cell Lung Carcinoma (NSCLC)
Status: RECRUITING
Conditions: Stage II-IIIB Non-small Cell Lung Carcinoma
Interventions: DRUG: Osimertinib 80 mg/40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Analyze the Efficacy of Chronic Intake With a β-alanine Supplement in Recreational Cyclists
Status: COMPLETED
Conditions: Beta Alanine Supplementation
Interventions: DIETARY_SUPPLEMENT: Beta Alanine high dose|DIETARY_SUPPLEMENT: Beta Alanine low dose|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of the Clinical Safety, Tolerability, and Efficacy of Zoledronic Acid Compared to an Oral Bisphosphonate
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Invisible Fishers
Status: COMPLETED
Conditions: Anemia
Interventions: BEHAVIORAL: Mobile phone audio messaging|BEHAVIORAL: Peer-to-peer learning|BEHAVIORAL: Conditional cash transfer|BEHAVIORAL: Entrepreneurship training|BEHAVIORAL: Market price information|BEHAVIORAL: Improved smoke ovens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment and Treatment Patients With Atypical Facial Pain Trough Repetitive Transcranial Magnetic Stimulation
Status: COMPLETED
Conditions: Atypical Facial Pain or Atypical Odontalgia
Interventions: PROCEDURE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Besifloxacin Ophthalmic Suspension Verses Gatifloxacin Ophthalmic Solution in Neonates With Bacterial Conjunctivitis
Status: TERMINATED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: Besivance|DRUG: Gatifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Virtual Reality and Passive Distraction on Burn Wound Care Pain in Adolescents
Status: TERMINATED
Conditions: Burns|Wound Care|Pain
Interventions: DEVICE: Virtual Reality|OTHER: Passive Distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigating ProCare4Life Impact on Quality of Life of Elderly Subjects With Neurodegenerative Diseases
Status: COMPLETED
Conditions: Neurodegenerative Diseases|Parkinson Disease|Alzheimer Disease|Quality of Life
Interventions: DEVICE: PC4L solutions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improved Therapy Response Assessment in Metastatic Brain Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain Metastases
Interventions: DIAGNOSTIC_TEST: Magnetic Resonance Imaging|RADIATION: Stereotactic Radiosurgery|DRUG: Ipilimumab, nivolumab or pembrolizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Digital Technique to Analyze the Wear of Implants and Natural Tooth as Antagonist.
Status: COMPLETED
Conditions: Dental Prosthesis Failure
Interventions: PROCEDURE: The wear of screw-retained implant-supported metal-ceramic dental prostheses and natural tooth
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Testosterone-Driven Growth-Hormone (GH) Secretion in Aging Men
Status: COMPLETED
Conditions: Aging
Interventions: DRUG: Placebo|DRUG: Testosterone|DRUG: Anastrazole|DRUG: Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open-Label, Safety, and Efficacy Study of Dexmedetomidine in Preterm Subjects Ages ≥28 Weeks to <36 Weeks Gestational Age
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam|DRUG: Fentanyl|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: B Cell Lymphocyte in Humoral Rejection and Alloimmunisation
Status: UNKNOWN
Conditions: Renal Transplant
Interventions: OTHER: Presence of DSA w/ cAMR|OTHER: Presence of DSA w/o cAMR|OTHER: No DSA No cAMR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: This Study Tests BI 1467335 in Healthy Japanese and Caucasian Men. The Study Tests How Different Doses of BI 1467335 Are Taken up in the Body and How Well They Are Tolerated
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1467335|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Cognitive Intervention in Amnestic Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: group cognitive intervention|OTHER: Home-based cognitive intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Mobocertinib Capsules in People With Severe Kidney Problems and People With Healthy Kidneys
Status: COMPLETED
Conditions: Renal Impairment|Healthy Volunteers
Interventions: DRUG: Mobocertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: First-in-Human Study With GNbAC1 in Healthy Volunteers
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: GNbAC1|BIOLOGICAL: GNbAC1 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT