pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Pharmacokinetic Characteristics After Administration of HIP1503 and HGP1103 in Healthy Male Volunteers
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: HIP1503|DRUG: HGP1103
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers
Status: UNKNOWN
Conditions: Acute Kidney Injury
Interventions: DIETARY_SUPPLEMENT: Fructose/glucose/xylitol/saccharose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia
Status: COMPLETED
Conditions: Localized Provoked Vulvodynia
Interventions: PROCEDURE: Pelvic floor physical therapy|DRUG: estriol cream (ovestin)|PROCEDURE: Low-level-laser therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A First-in-Human Study of RPT193 in Healthy Volunteers and Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: RPT193|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Long-term Safety and Effectiveness of Fostamatinib in the Treatment of Rheumatoid Arthritis (RA)
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Fostamatinib|DRUG: Fostamatinib|DRUG: Fostamatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Thrombopoietin in Combination With Rituximab in Immune Thrombocytopenia (ITP)
Status: COMPLETED
Conditions: Purpura|Idiopathic Thrombocytopenic Purpura
Interventions: DRUG: rhTPO in combination with Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DT PACE, Tandem Autologous Transplant, Maintenance Therapy for Waldenstrom's Macroglobulinemia Patients
Status: TERMINATED
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: DT PACE + Rituxan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Capmatinib|DRUG: Amivantamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Optimization of Blood Pressure and Fluid Status Control With Eight-Polar Bioelectrical Impedance Analysis
Status: COMPLETED
Conditions: Hypertension|Fluid Overload|Heart Diseases
Interventions: DEVICE: Bioelectrical impedance-guide dry weight reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Shoulder Musculoskeletal Disorders in Type 2 Diabetes Mellitus: Contributing Factors and Rehabilitation Protocol"
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Musculoskeletal Pain|Shoulder Pain
Interventions: OTHER: Shoulder rehabilitation exercises and aerobic exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral and Neural Correlates of Post-Stroke Fatigue
Status: RECRUITING
Conditions: Stroke|Fatigue
Interventions: DEVICE: Anodal transcranial direct current stimulation|DEVICE: Sham transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Interventional Lymphangioleiomyomatosis (LAM) Early Disease Trial
Status: RECRUITING
Conditions: LAM|Lymphangioleiomyomatosis
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Diagnostic Sensitivity and Specificity of the Determine™ Syphilis Advanced Test.
Status: NOT_YET_RECRUITING
Conditions: Syphilis Infection
Interventions: DIAGNOSTIC_TEST: Diagnostic test: Determine™ Syphilis Advanced test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cleave-stage Transfer on Day 3 Versus Day 5 Transfer When Only One Embryo Available
Status: TERMINATED
Conditions: Infertility
Interventions: OTHER: Embryo transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of Soluble Beta-1,3/1,6-glucan (SBG) Versus Placebo in Chronic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetes|Diabetic Ulcer
Interventions: DRUG: SBG|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GEriatric Determinants of Curative RAdiotherapy Scheme Choice for Breast Cancer ELderly Patient Treatment Compliance and Tolerance
Status: TERMINATED
Conditions: Breast Cancer
Interventions: OTHER: Onco Geriatric Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula
Status: COMPLETED
Conditions: Rectovaginal Fistula
Interventions: PROCEDURE: Injection of autologous regenerative cells of adipose tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HLX301 (TIGIT×PDL1 Bispecific) in Patients With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors|Non-small Cell Lung Cancer
Interventions: DRUG: HLX301
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enteral Feeding Composition and Acute Respiratory Failure
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: OTHER: high-protein low-carbohydrate diet with high olive oil|OTHER: high-protein low-carbohydrate diet with high sunflower oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Simple Cognitive Task Intervention After Trauma During COVID-19 In Hospital Staff EKUT-P RCT
Status: COMPLETED
Conditions: Intrusive Memories of Traumatic Event(s)|Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Simple cognitive task intervention|BEHAVIORAL: Attention Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single Incision Laparoscopic Surgery vs Flexible Single Incision Surgery for Cholecystectomy
Status: COMPLETED
Conditions: Cholelithiasis|Surgery|Laparoscopy
Interventions: PROCEDURE: SILS Cholecystectomy|PROCEDURE: FSIS cholecystectomy|PROCEDURE: Conventional laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Mechanism of Ganoderma Lucidum Spore Powder in the Treatment of Depression
Status: COMPLETED
Conditions: Depression|Thyroid Cancer
Interventions: DIETARY_SUPPLEMENT: Ganoderma lucidum spore powder|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC
Status: RECRUITING
Conditions: Punctate Palmoplantar Keratoderma Type 1|Pachyonychia Congenita
Interventions: DRUG: KM-001 cream 1% 12 weeks treatment.|DIAGNOSTIC_TEST: Physical Examination|DIAGNOSTIC_TEST: Vital Signs|DIAGNOSTIC_TEST: Serum chemistry|DIAGNOSTIC_TEST: Hematology|DIAGNOSTIC_TEST: Serology|DIAGNOSTIC_TEST: Urinalysis|DIAGNOSTIC_TEST: ECG test|DIAGNOSTIC_TEST: Pharmacokinetics Assessments|DIAGNOSTIC_TEST: Clinical global impression of severity (CGI-S)|DIAGNOSTIC_TEST: Visual Analogue Scale (VAS) pain scale|DIAGNOSTIC_TEST: Peak pruritus-numerical rating scale (PP-NRS)|DIAGNOSTIC_TEST: Patient global impression of change (PGI-C) scoring|DIAGNOSTIC_TEST: Patient global impression of severity (PGI-S) scoring|DIAGNOSTIC_TEST: Lesion photography|DRUG: KM-001 cream 1% 16 weeks treatment.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta Agonist Nebulization in Non Invasively Ventilated COPD Patients: Safety, and Therapeutic Efficacy Range.
Status: COMPLETED
Conditions: Chronic Respiratory Failure
Interventions: DRUG: Salbutamol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacist-led Intervention on Adherence in Patients Undergoing Treatment With an Oral Oncology Medication
Status: COMPLETED
Conditions: Adherence, Medication
Interventions: BEHAVIORAL: pharmacist-intervention|BEHAVIORAL: Historical control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Double-Blind, Randomized Parallel Group Study Comparing Procysteine to Placebo in HIV-Infected Patients Who Are Taking Antiretroviral Nucleosides
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Procysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Insulin-based Strategies to Prevent Hypoglycemia During Two Types of Exercise
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: OTHER: Continous exercise|OTHER: Interval exercise|OTHER: Reduction of basal insulin by 40%|OTHER: Reduction of basal insulin by 80%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of VIMOVO in Adolescents With Juvenile Idiopathic Arthritis (JIA)
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis (JIA)
Interventions: DRUG: VIMOVO 250/20|DRUG: VIMOVO 375/20|DRUG: VIMOVO 500/20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collecting, Analyzing, and Storing Samples From Patients With Metastatic, Triple Negative Breast Cancer Receiving Anti-cancer Therapy
Status: TERMINATED
Conditions: Estrogen Receptor Negative|HER2/Neu Negative|Progesterone Receptor Negative|Stage IV Breast Cancer AJCC v6 and v7|Triple-Negative Breast Carcinoma
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LED Light As An Adjunct Treatment Modality of Periodontal Diseases
Status: UNKNOWN
Conditions: Periodontal Diseases
Interventions: DEVICE: LED appliance during mechanical debridement|DEVICE: LED appliance after mechanical debridement|DEVICE: Mechanical debridement alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis
Status: COMPLETED
Conditions: Cholestasis
Interventions: DRUG: sincalide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Personalized Prevention for Couples: A 16-month Digital RCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Hiv|HIV Infections|Sexually Transmitted Infection|Sexually Transmitted Diseases|Sexual Behavior|Risk Reduction
Interventions: BEHAVIORAL: Intervention LuvHub|BEHAVIORAL: Waitlist Control LuvHub
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Clofarabine, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk and/or Advanced Hematologic Cancer or Other Disease
Status: COMPLETED
Conditions: Graft Versus Host Disease|Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: filgrastim|DRUG: clofarabine|DRUG: melphalan|DRUG: mycophenolate mofetil|DRUG: tacrolimus|DRUG: thiotepa|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Serum Infliximab Levels in Severe Ulcerative Colitis.
Status: COMPLETED
Conditions: Ulcerative Colitis (UC)|Inflammatory Bowel Disease
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Surfaces on Fall in Elderly
Status: COMPLETED
Conditions: Falls, Accidental|Aging
Interventions: OTHER: Physical training on hard surface.|OTHER: Physical training on sand surface.|OTHER: Physical training on soft surface.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Power of Self-efficacy-based Interventions in Fostering Caring Self-efficacy and Overcoming Job-related Stress and Perceived Stigma Among Psychiatric Nurses
Status: RECRUITING
Conditions: Caring Efficacy
Interventions: BEHAVIORAL: self-efficacy-based interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Postoperative Sore Throat: Interest of the Videolaryngoscope
Status: COMPLETED
Conditions: Sore-throat|Anesthesia|Postoperative Pain|Tracheal Intubation Morbidity
Interventions: PROCEDURE: tracheal intubation by Videolaryngoscope|PROCEDURE: tracheal intubation by direct laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Ibrutinib in Patients With Relapsed or Refractory Primary Central Nervous Lymphoma or Intraocular Lymphoma
Status: COMPLETED
Conditions: Primary Central Nervous Lymphoma|Intraocular Lymphoma
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study for Eradication of Refractory Helicobacter Pylori
Status: UNKNOWN
Conditions: Gastritis
Interventions: DEVICE: The result of H pylori culture based on gram staining and enzyme activity testing|DEVICE: The result of 13C-urea breath test after treatment based on the selection of clarithromycin, levofloxacin, metronidazole, amoxicillin，tetracycline，furazolidone and the dose of esomeprazole|DEVICE: The result of Amoxicillin resistance in vitro based on antibiotic susceptibility testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immune Response of DNA/MVA Vaccines in HIV-1-Infected Young Adults Taking Anti-HIV Medications
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: GEO-D03 DNA Vaccine|BIOLOGICAL: MVA/HIV62B Vaccine|BIOLOGICAL: Placebo for DNA GEO-D03|BIOLOGICAL: Placebo for MVA/HIV62B Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Metastatic Cancer
Interventions: DRUG: temsirolimus|OTHER: pharmacological study|OTHER: cytokine levels
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients' Perspective on Radiofrequency Catheter Ablation of AVRT and AVNRT
Status: COMPLETED
Conditions: Tachycardia, Atrioventricular Nodal Reentry|Re-entrant Atrioventricular Tachycardia
Interventions: PROCEDURE: RFA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Idelalisib in Combination With BI 836826 in Participants With Chronic Lymphocytic Leukemia
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: Idelalisib|DRUG: BI 836826
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Evaluation of Bioidentical Compounded Estrogen Cream and Natural Progesterone
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: bioidentical hormone (Biest)|DRUG: bioidentical hormone (Biest)|DRUG: bioidentical hormone (Biest)|DRUG: bioidentical hormone (Vivelle-Dot)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microscopic Skin Tissue Column Grafting Technique Using the Autologous Regeneration of Tissue System
Status: NOT_YET_RECRUITING
Conditions: Wound of Skin|Burns
Interventions: PROCEDURE: Split-thickness skin grafting|DEVICE: High density microscopic skin tissue column grafting|DEVICE: Low density microscopic skin tissue column grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Hydrogel vehicle|DRUG: Eucerin Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Food Advertisements, Satiety and Food Intake in Children
Status: COMPLETED
Conditions: Obesity Prevention
Interventions: DIETARY_SUPPLEMENT: Glucose with water|DIETARY_SUPPLEMENT: non-caloric sweetener with water|BEHAVIORAL: TV program with non-food advertisements while feeding|BEHAVIORAL: TV program with food advertisements while feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Insulin Glargine Versus Sitagliptin in Insulin-naive Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin Glargine|DRUG: Sitagliptin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Efficacy Study in Fistulizing Crohn's Disease Patients
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: QAX576|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improvement Effect of Transcranial Direct Current Stimulation (tDCS) Applied During Exercise Training in Stroke Patients With Upper Limb and Hand Motor Function
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: tDCS stimulation with hand task|DEVICE: sham tDCS stimulation with hand task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Central Venous Catheter Replacement Strategies in Adult Patients With Major Burn Injury
Status: UNKNOWN
Conditions: Catheter-related Bloodstream Infection|Complication of Catheter
Interventions: DEVICE: central venous catheter replacement (Arrowgard Blue plus Quad-Lumen CVC )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Withdrawal of Immunosuppression in Long Term Stable Liver Transplant Recipients
Status: UNKNOWN
Conditions: Liver Transplantation
Interventions: PROCEDURE: immunosuppression withdrawal|PROCEDURE: continue of taking immunosuppressant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining the Effects of a Telehealth Self-management Intervention in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Social Support Program|BEHAVIORAL: Physical Activity Program|BEHAVIORAL: Physical Activity Plus Fatigue Management Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness and Change Mechanisms of Mentalization Based Therapy for Children (MBT-C)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Disorder, Child
Interventions: BEHAVIORAL: Mentalization-Based Treatment for Children (MBT-C)|BEHAVIORAL: Parenting and Social Skills Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Learn to Quit-HIV Pilot Study
Status: COMPLETED
Conditions: HIV/AIDS|Smoking Cessation|Tobacco Use Disorder
Interventions: DEVICE: Learn to Quit-HIV|BEHAVIORAL: QuitGuide|DRUG: Nicotine patch|BEHAVIORAL: Smartphone coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Russian Kogenate Pediatric Study
Status: COMPLETED
Conditions: Hemophilia A
Interventions: DRUG: rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week|DRUG: rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg)|DRUG: rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LM11A-31-BHS in Mild-moderate AD Patients
Status: COMPLETED
Conditions: Mild to Moderate Alzheimer's Disease
Interventions: DRUG: 400mg LM11A-31-BHS|DRUG: 800mg LM11A-31-BHS|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Evaluate Emtricitabine/Tenofovir Alafenamide (F/TAF) in Human Immunodeficiency Virus 1 (HIV-1) Infected Children and Adolescents Virologically Suppressed on a 2- Nucleoside/Nucleotide Reverse Transcriptase Inhibitor (2-NRTI)-Containing Regimen
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1
Interventions: DRUG: F/TAF|DRUG: 3rd ARV agent|DRUG: Boosted PIs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe POTS
Status: WITHDRAWN
Conditions: Postural Orthostatic Tachycardia Syndrome
Interventions: BIOLOGICAL: Albumin (Human) 5%, USP|DRUG: Normal Saline 0.9% Infusion Solution Bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A New Clinical Pathway for Patients With Fractured Neck of Femur
Status: COMPLETED
Conditions: Hip Fracture|Aged
Interventions: PROCEDURE: geriatric work-up|PROCEDURE: Orthopedic care as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Femoral Nerve Blocks in Elderly Patients With Hip Fractures
Status: COMPLETED
Conditions: Femoral Neck Fractures|Hip Fractures
Interventions: DRUG: Femoral nerve block: 25 mL of 0.5% bupivacaine|DRUG: Placebo: 3cc of 0.9% Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interval Training and Cardio-metabolic Health in Overweight/Obese Girls
Status: RECRUITING
Conditions: Exercise Overtraining|Enjoyment|Cardiometabolic Syndrome|Obesity
Interventions: OTHER: MIIT|OTHER: MIIT + HIIT|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Team Birth Project
Status: COMPLETED
Conditions: Pregnancy Complications|Cesarean Section Complications|Maternal Complication of Pregnancy|Communication, Multidisciplinary
Interventions: BEHAVIORAL: Exposed study site
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pegaspargase and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: imatinib mesylate|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: pegaspargase|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin in Renal Transplant Recipients
Status: COMPLETED
Conditions: Diabetes Mellitus|Renal Insufficiency|Safety Issues
Interventions: DRUG: Empagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives
Status: TERMINATED
Conditions: Premenstrual Syndrome|PMS|Premenstrual Dysphoric Disorder|PMDD|Depression
Interventions: DRUG: Ethinyl Estradiol/Drospirenone|DRUG: Placebo|DRUG: CDB 2914
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Flutamide In the Prevention of Prostate Cancer in Patients With Neoplasia of the Prostate
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: flutamide|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Feeding Infant Formula Containing Prebiotics and/or Probiotics
Status: TERMINATED
Conditions: Metabolomics
Interventions: OTHER: Control: Cow milk-based infant formula|OTHER: Experimental 1: Cow milk-based infant formula|OTHER: Experimental 2: Cow milk-based infant formula|OTHER: Experimental 3: Cow milk-based infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: WP16302 A Bioequivalence Study Comparing Ganciclovir From the Valganciclovir Syrup Formulation and the Commercial Valganciclovir 450mg Tablet (Valcyte®) at a Dose of 900mg in Kidney Transplant Recipients
Status: TERMINATED
Conditions: Kidney Transplant
Interventions: DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD0530 Phase II Study in Patients With Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms|Ovarian Cancer
Interventions: DRUG: AZD0530|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7
Status: COMPLETED
Conditions: Prostate Cancer|Recurrent Prostate Carcinoma|Stage IV Prostate Adenocarcinoma
Interventions: BIOLOGICAL: Ipilimumab|BIOLOGICAL: Nivolumab|DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Postoperative Pain After Cesarean Delivery Using Bridge Auricular Percutaneous Nerve Field Stimulator
Status: NOT_YET_RECRUITING
Conditions: Post-operative Pain, Acute|Cesarean Section|Opioid Use Disorder|Opioids; Harmful Use
Interventions: DEVICE: Auricular percutaneous nerve field stimulator|DEVICE: Sham auricular percutaneous nerve field stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isoleucine, Leucine, Valine and Tryptophan Requirements in TPN Fed Neonates
Status: NOT_YET_RECRUITING
Conditions: Stable Neonates Receiving Total Parenteral Nutrition (TPN)
Interventions: DRUG: Total parenteral nutrition (TPN): this is total nutrition provided by central vein.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: To Evaluate the Effectiveness(Immunogenicity) and Safety of 'GC3102C' Administered Intramuscularly in Healthy Adults
Status: COMPLETED
Conditions: Prophylaxis Against Influenza
Interventions: BIOLOGICAL: GC3102C|BIOLOGICAL: GC FLU inj.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial of Diet in Gestational Diabetes Mellitus: Metabolic Consequences to Mother and Offspring
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: BEHAVIORAL: Low Carbohydrate/Conventional|BEHAVIORAL: Choosing Healthy Options in Carbohydrate Energy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712)
Status: COMPLETED
Conditions: Pregnancy|Neonates
Interventions: DRUG: Corifollitropin Alfa 150 μg|BIOLOGICAL: 200 IU RecFSH/Follitropin beta (Days 1 to 7)|DRUG: Placebo for Corifollitropin Alfa|DRUG: Placebo for RecFSH/Follitropin beta|BIOLOGICAL: 200 IU RecFSH/Follitropin beta (Days 8 to hCG)|DRUG: Ganirelix|BIOLOGICAL: hCG|BIOLOGICAL: Progesterone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: STD Risk Reduction for Heterosexual Methamphetamine Users
Status: COMPLETED
Conditions: Substance-Related Disorders|HIV Infections|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Tri-focal cognitive behavioral therapy - social skills training (CBTSS) counseling program|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RELATE - Efficacy and Feasibility of a Cognitive Behavioural Module for Distressing Auditory Verbal Hallucinations
Status: COMPLETED
Conditions: Verbal Auditory Hallucination|Psychotic Disorders|Psychosis|Schizophrenia
Interventions: BEHAVIORAL: Relating Therapy|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety, and Tolerability of Efzofitimod in Patients With Systemic Sclerosis (SSc)-Related Interstitial Lung Disease (ILD) (SSc-ILD)
Status: RECRUITING
Conditions: Interstitial Lung Disease
Interventions: DRUG: efzofitimod 450 mg|DRUG: efzofitimod 270 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Diastolic Dysfunction
Interventions: DIETARY_SUPPLEMENT: MITOQUINOL MESYLATE then placebo|DIETARY_SUPPLEMENT: Placebo, then MITOQUINOL MESYLATE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Single Dose Morphine and Fentanyl Added to Intrathecal Mixture on Orthopedics Patients With Undiagnosed Obstructive Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea of Adult
Interventions: DRUG: Morphine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cocoa Flavanol Intake and Exercise in Hypoxia
Status: COMPLETED
Conditions: Hypoxia, Altitude
Interventions: DIETARY_SUPPLEMENT: cocoa flavanol|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Primary Vaccination Course in Children Receiving Pneumococcal Conjugate Vaccine GSK 1024850A or Prevenar™ and Hiberix™
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: Pneumococcal vaccine GSK1024850A (Synflorix)|BIOLOGICAL: Prevenar|BIOLOGICAL: GSK Biologicals' Hiberix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses
Status: RECRUITING
Conditions: Lower-limb Orthoses|Frailty/Sarcopenia|Chronic Overuse Musculoskeletal Injuries
Interventions: DEVICE: Modular powered orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Keratoconus, Cross-linking and Cross-linking Combined With Topo-guided Photorefractive Keratectomy on Self-reported Quality of Life. A Three-year Update.
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: Corneal Cross Linking|PROCEDURE: Corneal Cross Linking combined with topoguided PRK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Open-Label Investigator Sponsored Trial to Investigate the Safety, Tolerability and Development of Subfoveal Fibrosis By Intravitreal Administration of Altering Regimens of Fovista and Anti-VEGF Therapy in Subjects With Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: Fovista™|DRUG: Lucentis®|DRUG: Avastin®|DRUG: Eylea®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Five-Year Actively Controlled Clinical Trial in New Onset Juvenile Systemic Lupus Erythematosus Nephritis
Status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus Nephritis
Interventions: DRUG: cyclophosphamide-prednisone-azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Pressure Pain Threshold of Jaw Muscles in TMD Patients Submitted to a Conservative Treatment
Status: UNKNOWN
Conditions: Pain|Myofascial Pain|Temporomandibular Disorder Syndrome|Therapeutic Exercise|Facial Pain
Interventions: BEHAVIORAL: counseling and exercises|BEHAVIORAL: lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Intraarticular Sodium Hyaluronate Single Injection in Patients With Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Sodium hyaluronate 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Marrow Irradiation and High-dose Melphalan for Double Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: RADIATION: Total marrow irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors
Status: TERMINATED
Conditions: Dilated Cardiomyopathy
Interventions: DRUG: perindopril|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Negative Affect in Low Back Pain Patients
Status: RECRUITING
Conditions: Chronic Low Back Pain|Negative Affectivity
Interventions: DRUG: Antidepressant|OTHER: Enhanced Fear Avoidance Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Sleep Deprivation on Whole-body Heat Exchange During Exercise-heat Stress in Young and Older Men
Status: COMPLETED
Conditions: Thermoregulation|Sleep Disturbance|Heat Exchange|Aging|Exercise
Interventions: OTHER: Sleep deprivation|OTHER: Normal sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Myofascial Release and Neuromuscular Training for Pes Anserine Syndrome Associated With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pes Anserine Bursitis
Interventions: OTHER: Myofascial release|OTHER: Neuromuscular exercises|OTHER: Cold pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Using (PEKK) Framework Versus (Co- Cr) Framework on The Bone of Mandibular Implant Supported Hybrid Prostheses
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of MK-6194 (PT101) in Participants With Active Ulcerative Colitis (UC) (MK-6194-002)
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: MK-6194|DRUG: MK-6194-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of YM155 in Refractory Diffuse Large B-cell Lymphoma (DLBCL) Subjects
Status: TERMINATED
Conditions: Lymphoma, Large-Cell, Diffuse|Lymphoma, B-Cell Refractory
Interventions: DRUG: YM155
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally-invasive Surgery Versus Craniotomy in Patients With Supratentorial Hypertensive Intracerebral Hemorrhage
Status: COMPLETED
Conditions: Intracranial Hemorrhage, Hypertensive
Interventions: PROCEDURE: Endoscopic Evacuation|PROCEDURE: Stereotactic Aspiration|PROCEDURE: Craniotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Fecal Microbiota Transplantation in Children With ASD
Status: ENROLLING_BY_INVITATION
Conditions: Autism Spectrum Disorder
Interventions: BIOLOGICAL: Fecal microbiota transplantation|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery
Status: UNKNOWN
Conditions: Craniofacial Abnormalities|Maxillofacial Abnormalities|Cleft Lip|Cleft Palate
Interventions: PROCEDURE: 3D stereophotogrammetric imaging|PROCEDURE: 3D CT-imaging with cone-beam CT|PROCEDURE: Case report form
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SpaceIT Hydrogel System for Perirectal Spacing
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DEVICE: SpaceIT Hydrogel System|DEVICE: Commercially available Boston Scientific Spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Transdiagnostic Mentalization-based Intervention for Parents With Mental Disorders
Status: RECRUITING
Conditions: Mental Disorder|Behavior Disorders|Diagnosis, Psychiatric|Diagnosis Dual|Severe Mental Disorder|Mental Illness|Psychiatric Disorder|Psychiatric Disease|Psychiatric Illness
Interventions: BEHAVIORAL: Lighthouse MBT Parenting Program (LPP)|BEHAVIORAL: Care as usual (CAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weekly Family Food Packages: Food is Medicine
Status: ENROLLING_BY_INVITATION
Conditions: Food Insecurity|Overweight|Obesity|Cardiometabolic Syndrome
Interventions: OTHER: Weekly Family Food Packages|BEHAVIORAL: Family Health Group Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RC1012 Injection (Allo-DNT Cells) for the Prevention of Relapse in AML Patients After Allo-HSCT
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: RC1012 injection (allo-DNT cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients With Advanced Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|mCRPC|mCSPC
Interventions: DRUG: PRL-02 injection|DRUG: prednisone|DRUG: dexamethasone|DRUG: docetaxel infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
Status: UNKNOWN
Conditions: Bladder Cancer|Brain and Central Nervous System Tumors|Esophageal Cancer|Intraocular Melanoma|Kidney Cancer|Lymphoma|Melanoma (Skin)|Pancreatic Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter
Interventions: GENETIC: DNA analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Montelukast Sodium Chewable 5mg Tablet Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Torrent's Montelukast Sodium chewable Tablets 5mg|DRUG: Singulair® (Montelukast Sodium) Chewable Tablets 5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Testing the Efficacy of Social Robot-led Yoga
Status: COMPLETED
Conditions: Testing the Efficacy of Social Robot-led Yoga
Interventions: OTHER: Yoga (Robot-instructed)|OTHER: Yoga (Human-instructed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Psycho-Educational Interventions in Communication Partners of Older Adults With Hearing Impairment
Status: NOT_YET_RECRUITING
Conditions: Older Adults|Hearing Impairment|Nursing|Communication Partners
Interventions: BEHAVIORAL: Group-based multi-component psychoeducational inventions (GMC-PEIs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Effectiveness and Tolerability of a Second Maintenance Treatment in Participants With Ovarian Cancer, Who Have Previously Received Polyadenosine 5'Diphosphoribose [Poly (ADP Ribose)] Polymerase Inhibitor (PARPi) Treatment.
Status: WITHDRAWN
Conditions: Ovarian Cancer
Interventions: DRUG: Olaparib|DRUG: Ceralasertib|DRUG: Placebo to match olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination With Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Patients
Status: UNKNOWN
Conditions: Anxiety
Interventions: DRUG: Midazolam|DRUG: Dexmedetomidine|DRUG: Midazolam and Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT