pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparison of MECHANISM of Early and Late Vascular Responses Following Treatment of ST-elevation Acute Myocardial Infarction With Two Different Everolimus-eluting Stents: Randomized Controlled Trial Between Biodegradable Polymer and Durable Polymer Stent (MECHANISM-AMI-RCT)
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of an Indoor Cycling Program on Cardio-Metabolic Factors in Women With Obesity and Normal Body Weight
Status: COMPLETED
Conditions: Obesity|Dyslipidemias|Hypertension|Type 2 Diabetes|Endothelial Dysfunction
Interventions: BEHAVIORAL: Indoor Cycling Interval Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of an Antiarrhythmic Drug to Treat Atrial Fibrillation in Patients With Pacemakers
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: ATI-2042|DRUG: ATI-2042 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients.
Status: COMPLETED
Conditions: Dentist-Patient Relations
Interventions: DRUG: Curcumin|DEVICE: LED|DRUG: Surfactant|DRUG: DMSO + water|DRUG: Chlorhexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Pharmacokinetics and Safety of BDP HFA Nasal Aerosol
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: BDP HFA Nasal Aerosol|DRUG: BDP HFA Nasal Aerosol|DRUG: BDP HFA Inhalation Aerosol (QVAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: A Study Evaluating Cadonilimab Injection in Combination With Regorafenib for the Treatment of Biliary Systemic Tumours
Status: RECRUITING
Conditions: Advanced Biliary Systemic Tumours That Has Failed at Least One Prior Systemic Therapy
Interventions: DRUG: Cadonilimab Injection|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MRD-associated Non-intensive But Non-interruptive Treatment of Ph-negative Acute Lymphoblastic Leukemia Adult Patients
Status: RECRUITING
Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions: DRUG: blinatumomab for B-ALL, venetoclax for T-ALL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Effects of Intensity and Delivery Style for Toddlers With Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Early Start Denver Model (ESDM)|BEHAVIORAL: Early Intensive Behavioral Intervention (EIBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients
Status: RECRUITING
Conditions: Bipolar I Disorder
Interventions: DRUG: Endoxifen|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pulse Radiofrequency and Occipital Nerve Block for Chronic Migraine Patients
Status: RECRUITING
Conditions: Chronic Migraine, Headache|Block|Occipital Neuralgia
Interventions: PROCEDURE: Greater occipital nerve block|PROCEDURE: Greater occipital nerve pulse radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Foot Thermometry and SMS and Voice Messaging to Prevent Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: BEHAVIORAL: SMS and voice messaging|DEVICE: Thermometry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: S0536: Cetuximab, Paclitaxel, Carboplatin, and Bevacizumab in Treating Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Recurrent Non-small Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: paclitaxel|BIOLOGICAL: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whey Protein Supplementation Associated With Resistance Training on Health Indicators in Trained Older Women
Status: COMPLETED
Conditions: Body Composition|Healthy
Interventions: DIETARY_SUPPLEMENT: Whey protein-placebo|DIETARY_SUPPLEMENT: Placebo-whey protein|DIETARY_SUPPLEMENT: Placebo-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Out of Plane Approach for Interscalene
Status: TERMINATED
Conditions: Acute Pain|Brachial Plexus Block
Interventions: PROCEDURE: Group 1 In-plane|PROCEDURE: Group 2 out of plane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Ipilimumab With Abiraterone Acetate Plus Prednisone in Chemotherapy and Immunotherapy-naïve Patients With Progressive Metastatic Castration-resistant Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of a Technology-enabled Disease Management Program to Reduce Hospitalizations for Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure|Diastolic Heart Failure|Systolic Heart Failure
Interventions: OTHER: Expanded technology disease management|OTHER: Telephonic disease management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment and Augmentation of Lip Appearance in Specific Study Populations
Status: COMPLETED
Conditions: Lip Aging|Lip Augmentation|Lip
Interventions: DRUG: Hyaluronic acid filler
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Therapeutic Efficacy in Use of Chamomilla Gel, Chamomilla Infuse and Urea in Radiodermatitis
Status: UNKNOWN
Conditions: Radiodermatitis
Interventions: OTHER: Chamomila recutita Gel|OTHER: Chamomila recutita Infuse|DRUG: Urea cream based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of Contrast Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Cysts
Status: COMPLETED
Conditions: Pancreatic Cyst
Interventions: DIAGNOSTIC_TEST: Contrast enhanced harmonic endoscopic ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Non Invasive Measurements of Intracranial Pressure in Patients With Malignant Glioma
Status: COMPLETED
Conditions: Glioma
Interventions: DEVICE: noninvasive method of ICP measurements (Elios)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome
Status: COMPLETED
Conditions: Alagille Syndrome
Interventions: DRUG: LUM001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bridging Study of Liposomal Cytarabine-Daunorubicin in Treating Olderly Patients With Treatment-naive High-Risk (Secondary) Acute Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: High-risk (Secondary) Acute Myeloid Leukemia
Interventions: DRUG: Liposomal cytarabine-daunorubicin for injection|DRUG: 7+3 (cytarabine and daunorubicin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study For Which Treatment, Tadalafil or Sildenafil, is Preferred For Problems Getting or Maintaining an Erection
Status: COMPLETED
Conditions: Impotence
Interventions: DRUG: tadalafil|DRUG: sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Use of a Silastic Spring-Loaded Silo for Infants With Gastroschisis
Status: TERMINATED
Conditions: Gastroschisis
Interventions: PROCEDURE: Primary placement of a spring-loaded silo|PROCEDURE: Primary Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Misoprostol+Oxytocin vs. Carbetocin in CS
Status: COMPLETED
Conditions: Cesarean Section
Interventions: DRUG: Misoprostol|DRUG: Oxytocin|DRUG: Carbetocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Blood and Tissue Samples From Patients With Stomach Cancer, Esophageal Cancer, or Gastroesophageal Junction Cancer
Status: UNKNOWN
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Esophageal Cancer|Gastric Cancer
Interventions: GENETIC: DNA analysis|GENETIC: RNA analysis|GENETIC: microarray analysis|GENETIC: protein analysis|OTHER: cytology specimen collection procedure|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Utilization of a Videoscope in Periodontal Regeneration
Status: RECRUITING
Conditions: Chronic Periodontitis
Interventions: DEVICE: Videoscope-assisted periodontal regeneration minimally invasive surgery|PROCEDURE: Periodontal regeneration minimally invasive surgery|PROCEDURE: Guided tissue regeneration surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of CAT-8015 Immunoxin in Patients With NHL With Advance Disease
Status: UNKNOWN
Conditions: Leukemia|Non-Hodgkin's Lymphoma|NHL
Interventions: DRUG: Immunotoxin therapy|DRUG: CAT-8015 Immunotoxin|PROCEDURE: Biological therapy|PROCEDURE: Antibody Therapy|PROCEDURE: Monoclonal Antibody Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi Tumor-Associated Antigen-Specific T Lymphocytes to Treat Patients With High Risk Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: BIOLOGICAL: Tumor-associated antigen-specific T cell (TAA-T)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety of a Personal Lubricant in Healthy Female Subjects
Status: COMPLETED
Conditions: Erythema|Edema
Interventions: DEVICE: Trojan "Simply Pleasure" Personal Lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lung Cancer STARS Trial - STARS Revised Clinical Trial Protocol: Stereotactic Ablative Radiotherapy (SABR) in Stage I Non-small Cell Lung Cancer Patients Who Can Undergo Lobectomy
Status: COMPLETED
Conditions: Lung Cancer
Interventions: RADIATION: Stereotactic Body Radiotherapy (SABR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Polytetrafluoroethylene (PTFE, MATFILL) for the Sealing of Prosthetic Chimneys.
Status: COMPLETED
Conditions: Edentulous Alveolar Ridge
Interventions: DEVICE: MATFILL (PTFE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: FASTFORWARDTM Bunion Correction System in Treating Hallux Valgus Patients
Status: UNKNOWN
Conditions: Hallux Valgus and Bunion (Disorder)
Interventions: DEVICE: FASTFORWARDTM Bunion|PROCEDURE: Conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Learn How a New Liquid Form of Rivaroxaban Behaves and How Safe it is Compared to the Current Tablet Form of Rivaroxaban in Healthy Male Participants
Status: COMPLETED
Conditions: Thromboembolic Disorders
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: botulinum toxin Type A (200U)|BIOLOGICAL: botulinum toxin Type A (300U)|OTHER: Normal saline (Placebo); botulinum toxin Type A (200U)|OTHER: Normal saline (Placebo); botulinum toxin Type A (300U)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Home Improvement Initiative of the TRaitement Optimisé Medicamenteux After Hospitalization
Status: UNKNOWN
Conditions: Older Adult|Chronic Disease|Clinical Pharmacy|Surgery|Ambulatory Care
Interventions: BEHAVIORAL: EOPC Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Label Trial on the Safety and Efficacy of Sym001 in the Treatment of Immune Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Immune Thrombocytopenic Purpura
Interventions: DRUG: Sym001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TENS Treatment for Bedwetting
Status: RECRUITING
Conditions: Nocturnal Enuresis|Bed Wetting
Interventions: DEVICE: pulse rate of 2 Hz|DEVICE: pulse rate of 10 Hz|DEVICE: pulse rate of 150 Hz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Four Interventions in the Management of Psychomotor Agitation, Safety and Efficacy Evaluation
Status: COMPLETED
Conditions: Psychomotor Agitation
Interventions: DRUG: haloperidol+promethazine|DRUG: haloperidol + midazolam|DRUG: olanzapine|DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Tolerability of Intravitreal LKA651 in Patients With Diabetic Macular Edema
Status: WITHDRAWN
Conditions: Diabetic Macular Edema
Interventions: BIOLOGICAL: LKA651 ophthalmic solution|BIOLOGICAL: Ranibizumab ophthalmic solution|BIOLOGICAL: Sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Efficacy and Safety of CT-P17 With Humira in Patients With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: CT-P17 SC|BIOLOGICAL: Humira SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rezum FIM Optimization Study
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia|Adenoma, Prostatic|Prostatic Adenoma|Prostatic Hyperplasia, Benign|Prostatic Hypertrophy|Prostatic Hypertrophy, Benign|Rezum
Interventions: DEVICE: Rezum System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Empagliflozin for Patients With Diabetes Mellitus and Planned Percutaneous Coronary Interventions
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes Mellitus|Percutaneous Coronary Intervention
Interventions: DRUG: Empagliflozin 10Mg Tab|DRUG: hypoglycemic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Dolutegravir in HIV-1 Infected Subjects With Virus Resistant to Raltegravir and/or Elivitegravir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dolutegravir 50 mg twice daily|DRUG: Dolutegravir placebo twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986406 as Monotherapy and Combination Therapies in Participants With Advanced Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Cancer
Interventions: BIOLOGICAL: BMS-986406|BIOLOGICAL: Nivolumab|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microsampling for Therapeutic Drug Monitoring of Oral Oncolytics in Oncology Patients
Status: NOT_YET_RECRUITING
Conditions: Drug Monitoring
Interventions: DIAGNOSTIC_TEST: Therapeutic drug monitoring with a dried blood spot and microatainer.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bortezomib, Rituximab, and Dexamethasone With or Without Temsirolimus in Treating Patients With Untreated or Relapsed Waldenstrom Macroglobulinemia or Relapsed or Refractory Mantle Cell or Follicular Lymphoma
Status: COMPLETED
Conditions: Recurrent Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Small Lymphocytic Lymphoma|Recurrent Waldenstrom Macroglobulinemia|Refractory Follicular Lymphoma|Refractory Mantle Cell Lymphoma|Refractory Marginal Zone Lymphoma|Refractory Non-Hodgkin Lymphoma|Refractory Small Lymphocytic Lymphoma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Rituximab|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Bacillus Containing Oral Hygiene Products on Gingivitis: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Gingivitis
Interventions: OTHER: probiotic oral hygiene products with Bacillus (PIP, Chrisal)|OTHER: oral hygiene products without Bacillus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Trametinib and Dabrafenib as a Potential Targeted Treatment in Cancers With BRAF Genetic Changes (MATCH-Subprotocol H)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: Dabrafenib Mesylate|DRUG: Trametinib Dimethyl Sulfoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omeza Combination Therapy for the Management and Treatment of Chronic Cutaneous Wounds/Ulcers of Multiple Etiologies
Status: COMPLETED
Conditions: Non-healing Wound|Non-Healing Ulcer of Skin
Interventions: COMBINATION_PRODUCT: Omeza Products Used in Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 2 Clinical Study of Pegerythropoietin Injection (RD01) for the Treatment of Anemia in Chronic Renal Failure Patients With Hemodialysis
Status: UNKNOWN
Conditions: Patient of Anemia in Chronic Renal Failure With Hemodialysis
Interventions: DRUG: RD01|DRUG: Recombinant Human Erythropoiesis Injection (CHO cell)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of TG103 Injection in Overweight/Obese Subjects Without Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: TG103 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
Status: COMPLETED
Conditions: Sepsis|Pneumonia|Gram-Negative Bacteria Infection|Multiple Organ Failure|Respiratory Distress Syndrome|Mortality|Biomarkers
Interventions: DRUG: Clarithromycin|DRUG: Water for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Two Fixed Dose Combinations of Aclidinium Bromide/Formoterol Fumarate, Aclidinium Bromide, Formoterol Fumarate and Placebo for 28-Weeks Treatment in Patients With Moderate to Severe, Stable Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Aclidinium bromide/formoterol Fixed-Dose Combination (FDC)|DRUG: Aclidinium bromide/formoterol Fixed-Dose Combination (FDC)|DRUG: Aclidinium bromide|DRUG: Formoterol Fumarate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Supplementation and Pancreatic β-Cell Function in Type 2 Diabetes
Status: COMPLETED
Conditions: Type2 Diabetes|Obesity|Insulin Resistance|Obesity, Abdominal
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hydrogen Peroxide ( H2O2) in Controlling Placental Site Bleeding in Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS)
Status: RECRUITING
Conditions: Placenta Accreta
Interventions: DRUG: packing placental site with hydrogen peroxide soaked towels|DRUG: normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting Response to Naltrexone With Eye Tracking in Videogame Disorder
Status: UNKNOWN
Conditions: Gaming Disorder
Interventions: DRUG: Naltrexone|DRUG: Placebo|BEHAVIORAL: Psychoeducational|DEVICE: Eye-tracking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Frontline Asciminib Combination in Chronic Phase CML
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Imatinib|DRUG: Nilotinib 300 mg|DRUG: Dasatinib|DRUG: Asciminib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Stair Climbing and One Mile Walking in Relation to Cardiorespiratory Fitness
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: DEVICE: 1 mile walk using treadmill|DEVICE: Stair Climbing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Measurements of Ketone Body Flux Versus Ketone Body Concentration as a Pharmacodynamic Marker of Hepatic Fatty Acid Oxidation (0000-110)
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Stable isotope tracer (13-C(4)-BHB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Participants Undergoing Radial Head Replacement Using the DePuy Synthes Radial Head Replacement System for Partial Replacement of the Elbow Joint
Status: WITHDRAWN
Conditions: Radial Head Fractures
Interventions: DEVICE: DePuy Synthes Radial Head Replacement System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Portal Hypertension and Systemic Endothelial Function
Status: UNKNOWN
Conditions: Cystic Fibrosis|Portal Hypertension
Interventions: OTHER: measure of endothelial function|BIOLOGICAL: Blood sample|OTHER: Hepatic elastography|DIAGNOSTIC_TEST: Injected abdominal CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Correlation of Solitary Dilated Duct at Mammography With Ultrasonography and Anatomopathological Findings
Status: COMPLETED
Conditions: Mammary Duct Ectasia of Unspecified Breast|Mammographic Findings|Female
Interventions: DIAGNOSTIC_TEST: Follow-up|DIAGNOSTIC_TEST: Ultrasound-guided percutaneous biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketamine- Propofol Versus Pethidine- Propofol in ERCP
Status: COMPLETED
Conditions: Sedation in ERCP
Interventions: DRUG: ketamine- propofol|DRUG: pethidine- propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Attention-Restorative Therapy (ART)-Based Virtual Reality Intervention to Address Cancer-Related Cognitive Impairments Among Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer Survivorship|Cancer-related Cognitive Impairment
Interventions: OTHER: Attention-restorative therapy (ART)-based virtual reality (VR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RGD-PET-CT in Cancer Angiogenesis
Status: TERMINATED
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: 18F-RGD-PET-CT and perfusion CT scans on 3 occasions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fasting Study of Controlled-Release Oxycodone Hydrochloride 40 mg Tablets and OxyContin® 40 mg Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Controlled-Release Oxycodone Hydrochloride 40 mg tablet|DRUG: OxyContin® 40 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Determining the Effects of Foley Catheter-assisted Nasal Intubation on Nasal Bleeding in Adult Patients
Status: UNKNOWN
Conditions: Nasal Bleeding
Interventions: DEVICE: Foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Men to Test How BI 1291583 is Taken up by the Body
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1291583|DRUG: [14C]-BI 1291583
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol Versus Sevoflurane on Acute Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: propofol and remifentanil|DRUG: sevoflurane and remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Lormetazepam and Midazolam Used as Sedatives for Patients That Require Intensive Care
Status: COMPLETED
Conditions: Sedation in Intensive Care Unit Patients
Interventions: DRUG: Lormetazepam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Disease|Myocardial Ischemia|Arterial Occlusive Diseases|Arteriosclerosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
Status: RECRUITING
Conditions: Medullary Thyroid Cancer|Infantile Myofibromatosis|Infantile Fibrosarcoma|Papillary Thyroid Cancer|Soft Tissue Sarcoma
Interventions: DRUG: LOXO-292
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study for the Degree of Biological Changes After Short-term 2 Weeks and 4 Weeks Preoperative Endocrine Therapy in Luminal Breast Cancer
Status: RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: Endocrine therapy|DRUG: Endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Thrombolysis, Ultrasound Assisted Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Embolism
Interventions: DRUG: Alteplase 20 Mg Powder for Solution for Injection Vial|DEVICE: Ultrasound assisted Thrombolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Uveal Melanoma
Interventions: BIOLOGICAL: IMCgp100|DRUG: Dacarbazine|BIOLOGICAL: Ipilimumab|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Behavioral Treatment for Anxiety in Young Children
Status: COMPLETED
Conditions: Obsessive-compulsive Disorder|Social Phobia|Generalized Anxiety Disorder|Specific Phobia|Separation Anxiety Disorder|Selective Mutism|Anxiety Disorder, Not Otherwise Specified
Interventions: BEHAVIORAL: Parent-Led Exposure Therapy|OTHER: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic and Zinc Supplementations on the Clinical Outcome in Pediatric Patients With Ventriculitis
Status: RECRUITING
Conditions: Ventriculitis, Infectious
Interventions: DRUG: Probiotic Formula|DRUG: Zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Informed Consent in Pediatric Endoscopy
Status: COMPLETED
Conditions: Informed Consent|Procedural State Anxiety|Subject's Satisfaction
Interventions: OTHER: Emmi Pediatric Upper Endoscopy Patient Education Module
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Itopride in Feeding Intolerance of Critically-ill Patients Receiving Enteral Nutrition
Status: UNKNOWN
Conditions: Critically-ill Patients
Interventions: DRUG: Itopride|DRUG: Metoclopramide 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peripheral and Central Influences on Auditory Temporal Processing & Speech Perception in Older Cochlear Implantees
Status: ENROLLING_BY_INVITATION
Conditions: Hearing Loss|Cochlear Hearing Loss|Hearing Loss, Sensorineural|Aging
Interventions: DIAGNOSTIC_TEST: Diagnostic tests of cochlear implant function|DIAGNOSTIC_TEST: Diagnostic tests of auditory function
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characterization and Support for Neurodevelopmental Disorders Associated With Congenital Heart Defects
Status: RECRUITING
Conditions: Congenital Heart Defects|Neurodevelopmental Disorder
Interventions: OTHER: Blood sampling|DIAGNOSTIC_TEST: Assessment of neurodevelopment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers
Status: TERMINATED
Conditions: Electronic Cigarettes
Interventions: OTHER: E-cigarette Lab Session 15 watts, 10 mg nicotine|OTHER: E-cigarette Lab Session 15 watts, 30 mg nicotine|OTHER: E-cigarette Lab Session 30 watts, 10 mg nicotine|OTHER: E-cigarette Lab Session 30 watts, 30 mg nicotine|OTHER: Own Brand Session - E-cigarette|OTHER: Own Brand Session - E-cigarette/Cigarette
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Impact of Prehabilitation on Recovery Following Open Surgery for Abdominal Aortic Aneurysm
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: OTHER: PREHABILITATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mindfulness to Reduce Ambulatory Hypertension in Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Hypertension|Mindfulness|Cardiovascular Risk Reduction
Interventions: BEHAVIORAL: Mindfulness-based coaching|BEHAVIORAL: Dietary cardiovascular risk reduction coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Detection of Barrett's Esophagus in Participants With Reflux Symptoms in Primary Care
Status: COMPLETED
Conditions: Barrett Esophagus|Esophageal Cancer
Interventions: DIAGNOSTIC_TEST: Breath test (eNose) followed by uTNE.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reproductive Aging and Obstructive Sleep Apnea
Status: WITHDRAWN
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Active CPAP|DEVICE: Sham CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Comparison of Bone Mineral Loss in Prostate Cancer Patients Who is Receiving GnRH Agonist and -Plus Anti-androgen Agent
Status: COMPLETED
Conditions: GnRH Agonist Alone vs. GnRH Agonist Plus Anti-androgen Combination Treated Prostate Cancer Patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Otago Exercise Program Applied By Telerehabilitation
Status: RECRUITING
Conditions: Older People--Abuse of|Falling|Balance; Distorted
Interventions: OTHER: telerehabilitation otago exercise program|OTHER: face to face otago exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hypothermia With Intrajugular Cooling in Acute Ischemic Stroke Thrombectomy
Status: UNKNOWN
Conditions: Acute Ischemic Stroke
Interventions: PROCEDURE: Hypothermia with intrajugular cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid Tumors
Status: WITHDRAWN
Conditions: Cancer|Non-small-cell Lung Cancer|Breast Cancer
Interventions: DRUG: XL647|DRUG: XL147
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polarization Perception in Health and Disease. Testing a New Sight Test
Status: UNKNOWN
Conditions: Cataract|Age Related Macular Degeneration|Pseudophakia|Macular Disease|Diabetic Retinopathy|Retinal Disease
Interventions: DIAGNOSTIC_TEST: polarization sensitivity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of COVID-19 Post-acute Cognitive Impairment Sequelae With tDCS
Status: COMPLETED
Conditions: Cognitive Impairment|Post-Acute Sequelae of SARS-CoV-2 Infection|COVID-19
Interventions: PROCEDURE: Active tDCS and cognitive training|PROCEDURE: Sham tDCS and cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety of Flomoxef Versus Cefepime in the Treatment of Participants With Urinary Tract Infections
Status: TERMINATED
Conditions: Urinary Tract Infection
Interventions: DRUG: Flomoxef|DRUG: Cefepime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Slow Response/Non-Rapid Response in Patients With Chronic Hepatitis C, Genotype 1, 2, 3 & 4 Treated With Pegasys (Peginterferon Alfa-2a) and Copegus (Ribavirin)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: peginterferon alfa-2a [Pegasys]|DRUG: ribavirin [Copegus]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pivotal Study of APG-2575 (Lisaftoclax) Combined With Azacytidine in the Treatment of Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Lisaftoclax (APG-2575)|OTHER: Placebo|DRUG: Azacitidine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Ablative Radiotherapy for Refractory Ventricular Tachycardia
Status: COMPLETED
Conditions: Refractory Ventricular Tachycardia
Interventions: RADIATION: Stereotactic Ablative Radiotherapy (SABR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Ultrasound Versus Fluoroscopy Guided S1 Injections and Radiofrequency
Status: COMPLETED
Conditions: Pain, Chronic
Interventions: PROCEDURE: Ultrasound-guided S1 Radiofrequency stimulation|PROCEDURE: Fluoroscopic-guided S1 Radiofrequency stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of a Regenerative Mitochondrial Medication on Physiological Parameters in Case of Diabetes Mellitus Type II
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type II
Interventions: DIETARY_SUPPLEMENT: Mitochondrial preparations|DIETARY_SUPPLEMENT: Infusion therapy|DEVICE: Webermedical device|BEHAVIORAL: Nutritional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Artificial Sweeteners on Blood Glucose Response
Status: WITHDRAWN
Conditions: Taste Receptors|Nutrient Sensing|Intestinal Absorption|Blood Glucose|Appetite
Interventions: DIETARY_SUPPLEMENT: Artificial Sweeteners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU
Status: COMPLETED
Conditions: Axial Spondyloarthritis (axSpA)|Anterior Uveitis (AU)
Interventions: DRUG: Certolizumab Pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Health Effects of Blueberry Anthocyanins in Metabolic Syndrome (the CIRCLES-study)
Status: COMPLETED
Conditions: Insulin Resistance|Metabolic Syndrome X
Interventions: OTHER: Full dose blueberry|OTHER: Half dose blueberry|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating the Impact of the Bridge Clinic in Patients With Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid Use|Opioid-use Disorder
Interventions: OTHER: Bridge Clinic|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Docosahexaenoic Acid (DHA) on Cardiovascular Disease on Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: First period DHA|DIETARY_SUPPLEMENT: Second period DHA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis
Status: NOT_YET_RECRUITING
Conditions: Adolescent Idiopathic Scoliosis (AIS)
Interventions: DRUG: open-label placebo|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LXRA Gene Polymorphisms and Response to Fenofibrate
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Fenofibrate capsule daily for 4 weeks|DRUG: Fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Efficacy and Safety of Buparlisib (BKM120) Plus Paclitaxel Versus Placebo Plus Paclitaxel in Recurrent or Metastatic Head and Neck Cancer Previously Pre-treated With a Platinum Therapy
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Buparlisib|DRUG: Buparlisib matching Placebo|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Probiotics to Allergic Pregnant Mother and Their Offspring to Prevent Allergic Disease
Status: WITHDRAWN
Conditions: Allergic Diseases
Interventions: DIAGNOSTIC_TEST: Physician diagnoses a history of asthma or eczema or allergic rhinitis or health pregnant women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Status: RECRUITING
Conditions: Osteoarthritis, Knee|Diabetic Neuropathic Pain|Chronic Low-back Pain
Interventions: DRUG: LY3016859 ISA|DRUG: LY3556050 ISA|DRUG: LY3526318 ISA|DRUG: LY3857210 ISA|DRUG: Placebo Oral|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Social Incentives to Improve Diabetes
Status: COMPLETED
Conditions: Type II; Diabetes|Obesity
Interventions: BEHAVIORAL: Supportive social incentive|BEHAVIORAL: Competitive social incentive|BEHAVIORAL: Collaborative social incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Monotherapy With Rapamycin in Long-standing Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: rapamycin|DRUG: Vildagliptin|DRUG: Placebo 1|DRUG: Placebo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: MART-1 antigen|BIOLOGICAL: filgrastim|BIOLOGICAL: flu matrix peptide p58-66|BIOLOGICAL: gp100 antigen|BIOLOGICAL: recombinant MAGE-3.1 antigen|BIOLOGICAL: tyrosinase peptide|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Use of Platelet-rich-fibrin in Lower Third Molar Surgery.
Status: COMPLETED
Conditions: Facial Swelling|Tooth Position Anomalies|Tooth, Impacted|Tooth Extraction Status Nos|Tooth Avulsion
Interventions: BIOLOGICAL: PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biological Function of Dreaming in Dreaming and Non-Dreaming Patients With PCA Infarction
Status: TERMINATED
Conditions: Dream Disorder|Thrombotic Infarction|PCA Infarct
Interventions: PROCEDURE: Polysomnographic examination in sleep laboratory (PSG measurement)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p