pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Novel Use of Extrapleural Autologous Blood Injection in CT-guided Percutaneous Lung Biopsy
Status: COMPLETED
Conditions: Lung Biopsy
Interventions: OTHER: EABPI plus IABPI|OTHER: IABPI-alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of 'Sniffing Position & Nasal Tip Lifting' in Nasotracheal Intubation
Status: COMPLETED
Conditions: Intubation Complication
Interventions: PROCEDURE: Sniffing position|PROCEDURE: Nasal tip lifting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: PIVKA-II Combined With Alpha-Fetoprotein for Diagnostic and Prognostic Value of Hepatic Tumors in Infants
Status: COMPLETED
Conditions: Hepatoblastoma|Hepatic Hemangioendothelioma
Interventions: DIAGNOSTIC_TEST: PIVKA-II
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Microneedle Patch With Botulinum Toxin in Management of Enlarged Facial Pores
Status: ACTIVE_NOT_RECRUITING
Conditions: Enlarged Pores
Interventions: DEVICE: Microneedle patch|DEVICE: Intradermal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potential Beneficial Effects of Resveratrol
Status: COMPLETED
Conditions: Metabolic Syndrome|Obesity
Interventions: DIETARY_SUPPLEMENT: Resveratrol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis
Status: RECRUITING
Conditions: HER2-negative Breast Cancer|Leptomeningeal Metastasis
Interventions: DEVICE: Ommaya reservoir|DRUG: Systematic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enrichment & Purging of Stem Cells in Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: PROCEDURE: high dose chemo then auto hematopoietic cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Insoles in Patients With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic|Foot Orthoses|Musculoskeletal Pain
Interventions: DEVICE: Custom-Made Foot Orthoses|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Intensive Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study
Status: RECRUITING
Conditions: Ischemic Stroke|Atrial Fibrillation
Interventions: OTHER: 7-day Holter ECG|OTHER: Implantable cardiac monitor|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-Term Safety and Efficacy of Imsidolimab (ANB019) in Subjects With Generalized Pustular Psoriasis
Status: TERMINATED
Conditions: Generalized Pustular Psoriasis
Interventions: BIOLOGICAL: Imsidolimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Bedside Placement of Nasal Jejunal Tube Confirmed by Ultrasound Compared to Placement by Endoscope in Patients With SAP
Status: UNKNOWN
Conditions: Bedside Placement of Nasal Jejunal Tube
Interventions: PROCEDURE: placing nasal jejunal tube with ultrasound|PROCEDURE: placing nasal jejunal tube endoscopically
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Stimulation to Treat Blepharospasm or Meige Syndrome
Status: COMPLETED
Conditions: Blepharospasm|Focal Dystonia
Interventions: PROCEDURE: repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study of Immediate Single Unit Implants in Early Loading Protocols, With or Without Photobiomodulation.
Status: RECRUITING
Conditions: Dental Implant|Tooth Absence|Tooth Extraction
Interventions: RADIATION: Low Laser Radiation|OTHER: Changing the implant surface|RADIATION: Low Laser Radiation off|PROCEDURE: Implant placement immediately after tooth extraction|PROCEDURE: Installing the dental crown with early loading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Corneal and Conjunctival Sensitivity and Staining Study
Status: COMPLETED
Conditions: Myopia|Hyperopia
Interventions: DRUG: Optifree RepleniSH Multipurpose Disinfecting Solution|DRUG: ReNu Multiplus Multipurpose Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: CD19+ Acute Leukemia
Interventions: BIOLOGICAL: Patient Derived CD19 specific CAR T cells also expressing an EGFRt
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Implication of Bone Marrow Perfusion Patterns Imaged by Dynamic MRI in Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma, Newly Diagnosed
Interventions: PROCEDURE: dynamic MRI and bone marrow sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients With Severe Preeclampsia
Status: COMPLETED
Conditions: Postpartum Preeclampsia
Interventions: DRUG: Diltiazem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lullaby and Breastmilk Smell on Preterm Newborns
Status: COMPLETED
Conditions: Preterm|Infant, Premature, Diseases|Postpartum Depression|Mother-Infant Interaction
Interventions: OTHER: Lullaby group|OTHER: Breast milk group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Research on Quantification of VR(Virtual Reality) Related Stress and Relaxation
Status: UNKNOWN
Conditions: Stress, Psychological|Motion Sickness|Visual Fatigue
Interventions: DEVICE: Existing Biofeedback|DEVICE: Biofeedback accompanied with virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial of Ublituximab and Umbralisib With CHOP (U2-CHOP) Followed by U2 Maintenance (U2-CHOP-U2) in Previously Untreated Mantle Cell Lymphoma (MCL)
Status: TERMINATED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Ublituximab|DRUG: Umbralisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Envafolimab Combined With Chemotherapy and Recombinant Human Endostatin in the First-line Treatment of Sq-NSCLC
Status: RECRUITING
Conditions: Squamous Non-small Cell Lung Cancer
Interventions: DRUG: "Envafolimab" and "Chemotherapy" and "Recombinant Human Endostatin"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: La CASA (Comunidad, Alimentación, Seguridad y Amén) Healthy Eating Intervention
Status: NOT_YET_RECRUITING
Conditions: Pediatric Obesity|Health Behavior, Risky
Interventions: BEHAVIORAL: La CASA (Comunidad, Alimentación, Seguridad y Amén) Program: Healthy Eating Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Single shot interscalene nerve block|DRUG: Continuous interscalene nerve block|DRUG: Local Infiltration Analgesia (LIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to MTX Therapy
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: ofatumumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atezolizumab Compared With Gemcitabine Plus (+) Cisplatin or Carboplatin for PD-L1-Selected Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower111)
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Atezolizumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bronchoscopic Microwave Intervention Treatment in Advanced Central NSCLC
Status: UNKNOWN
Conditions: Effect Increased|Safety Issues
Interventions: PROCEDURE: bronchoscopic microwave intervention|DRUG: anti-PD-1 / PD-L1 monoclonal antibody and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy Study of CTAP101 in Chronic Kidney Disease Subjects With Secondary Hyperparathyroidism (SHPT)
Status: COMPLETED
Conditions: Chronic Kidney Disease|Secondary Hyperparathyroidism|Vitamin D Insufficiency
Interventions: DRUG: Cohort 1 CTAP101 Capsules- 60µg|DRUG: Cohort 1 CTAP101 Capsules - 90µg|DRUG: Cohort 1 Matching Sugar Capsule|DRUG: Cohort 2 CTAP101 Capsules - 30µg|DRUG: Cohort 2 Matching Sugar Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Anticoagulation in Children - Thromboprophlaxis (COVAC-TP) Trial
Status: COMPLETED
Conditions: Infection Viral|Thromboses, Venous|COVID-19
Interventions: DRUG: Enoxaparin Prefilled Syringe [Lovenox]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Premium Trifocal IOL Comparative Analysis
Status: COMPLETED
Conditions: Cataract|Lens Opacities|Presbyopia
Interventions: DEVICE: POD F GF (BVI Medical), POD F (BVI Medical), Panoptix (Alcon Inc) IOL implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Acetaminophen in Morbidly Obese Patients
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: DRUG: acetaminophen 2 g
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Garnering Effective Telehealth 2 Help Optimize Multidisciplinary Team Engagement
Status: ENROLLING_BY_INVITATION
Conditions: Children With Complex Chronic Conditions
Interventions: BEHAVIORAL: GET2HOME Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Verbal Autopsy to Assess Early Neonatal Death and Stillbirth
Status: COMPLETED
Conditions: Perinatal Mortality|Cause of Neonatal Death|Cause of Stilbirth
Interventions: OTHER: Coordinator|OTHER: Physician-assigned cause of death
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating Safety & Efficacy Belinostat Combo w Nivo Alone & w Ipi in Patients w Treated Metastatic/Advanced Carcinomas w ARID1A Lof Mutation
Status: WITHDRAWN
Conditions: Metastatic Adenocarcinoma
Interventions: DRUG: Belinostat|DRUG: nivolumab|DRUG: ipilimumab|DRUG: nivolumab|DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PBM or Dry Float Therapy on Sleep Quality in Middle-aged and Elderly
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Quality
Interventions: DEVICE: NovoThor|DEVICE: VieLight|DEVICE: ZeroBody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Physical Therapy for Systemic Lupus Erythematosus (SLE)
Status: TERMINATED
Conditions: Lupus Erythematosus, Systemic|SLE
Interventions: BEHAVIORAL: Physical Therapy or Relaxation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of COVID-19 on Psychological Status in Case of IVF Interrupted or Postponed
Status: COMPLETED
Conditions: Infertility, Female|ART|IVF|COVID-19
Interventions: BEHAVIORAL: Generalized Anxiety Disorder-7 (GAD-7)|BEHAVIORAL: Patient Health Questionnaire-9 (PHQ-9)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Nucleo CMP Forte in Traumatic Brain Injury in Pediatrics
Status: RECRUITING
Conditions: Brain Injuries
Interventions: DRUG: Nucleo CMP Forte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of DXC006 in Patients With Advanced Solid Tumors and Hematologic Malignancies
Status: NOT_YET_RECRUITING
Conditions: Advanced Solid Tumors|Hematological Malignancies
Interventions: DRUG: DXC006
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ulcers Formation After Hand-Sewn vs Stapled Gastrojejunal Anastomosis In MGB.
Status: RECRUITING
Conditions: Ulcer Peptic
Interventions: PROCEDURE: Mini-gastric bypass with stapled anastomosis|PROCEDURE: Mini-gastric bypass with hand-sewn anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Characterisation of a New Wild-Type H3N2 Virus for the Human Viral Challenge Model
Status: COMPLETED
Conditions: Influenza
Interventions: OTHER: Infectious titre 1 (H3N2)|OTHER: Infectious titre 2 (H3N2)|OTHER: Infectious titre 3 (H3N2)|OTHER: Infectious titre 4 (H3N2)|OTHER: Infectious titre 5 (H3N2) (Subjects aged 18 to 45 years old)|OTHER: Infectious titre 5 (H3N2) (Subjects aged 46 to 64 years old)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Functional Postural Control Training on Functional Performance in People With Parkinson's Disease With Freezing of Gait
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Functional postural control training|OTHER: Treadmill training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intraoperative Oxygen Therapy on Oxygenation of Newborns Born Via Elective Cesarian Section
Status: COMPLETED
Conditions: Obstetrical Complication of Anesthesia
Interventions: OTHER: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cognitive Behavior Therapy and Work Outcome
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Support Group|BEHAVIORAL: Cognitive Behavior Therapy|BEHAVIORAL: Cognitive Remediation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROS-1-Male Hormonal Contraceptive Regimens on Prostate Tissue
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Testosterone gel|DRUG: Dutasteride|DRUG: Depo-Medroxyprogesterone (DMPA)|OTHER: Placebo Testosterone gel|OTHER: Placebo dutasteride|OTHER: Placebo DMPA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MOWOOT Device Treatment for Adults With Chronic Constipation
Status: NOT_YET_RECRUITING
Conditions: Constipation - Functional|Constipation-predominant Irritable Bowel Syndrome|Constipation Chronic Idiopathic|Constipation; Neurogenic|Constipation
Interventions: DEVICE: Intermittent Colonic Exoperistalsis with MOWOOT device|DEVICE: Standard of care with Trans-Anal Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Dose Escalation Study of VX-973 in Healthy Adults
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: VX-973|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Kinesio Tape Application With Different Verbal Input Given to With Patients With Rotator Cuff Tear
Status: COMPLETED
Conditions: Rotator Cuff Tear
Interventions: OTHER: Negative Verbal Input|OTHER: Neutral Verbal Input|OTHER: Positive Verbal Input
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib
Status: RECRUITING
Conditions: Brain Metastases|Human Epidermal Growth Factor 2 Positive Carcinoma of Breast|Advanced Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Trastuzumab Emtansine (T-DM1)|DRUG: Pertuzumab|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Clinical Effectiveness of RegenKit Platelet-rich Plasma (PRP) in Androgenetic Alopecia Treatment
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DEVICE: Autologous Platelet Rich Plasma|DEVICE: Saline solution injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Frailty Assessment and Treatment Strategies in the Elderly at Risk of Functional Decline in the Community
Status: COMPLETED
Conditions: Frail Elderly Syndrome
Interventions: OTHER: CGA, medication review, exercise and cognitive stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life 1y and 2 y After VV-ECMO for COVID-19
Status: COMPLETED
Conditions: COVID-19 Acute Respiratory Distress Syndrome|Extracorporeal Membrane Oxygenation Complication|Quality of Life|Death
Interventions: DEVICE: VV-ECMO
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sirolimus In Autosomal Dominant Polycystic Kidney Disease And Severe Renal Insufficiency
Status: TERMINATED
Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions: DRUG: Sirolimus|DRUG: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Women's Angiographic Vitamin and Estrogen Trial (WAVE)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Arteriosclerosis|Coronary Disease|Heart Diseases|Myocardial Ischemia|Postmenopause
Interventions: DRUG: estrogen replacement therapy|DRUG: estrogens, conjugated|DRUG: progesterone|DRUG: hormone replacement therapy|DRUG: supplementation, food|DRUG: ascorbic acid|DRUG: vitamin e
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Cheese Consumption and Human Microvascular Function
Status: COMPLETED
Conditions: Microvascular Dysfunction
Interventions: DRUG: Acetylcholine (ACh) Dose Response|DRUG: Local Heating (LH)|DRUG: Flow Mediated Dilation with nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Incentives for Primary Care Use in a Safety Net Setting
Status: COMPLETED
Conditions: Health Care Utilization|Primary Care Physician|Uninsured
Interventions: BEHAVIORAL: 0 dollars group|BEHAVIORAL: 50 dollars group|BEHAVIORAL: 25 dollars group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of ANKASCIN 568-P Products Regulating Blood Lipid
Status: NOT_YET_RECRUITING
Conditions: Hyperlipidemias
Interventions: DIETARY_SUPPLEMENT: ANKASCIN 568-P Red yeast rice capsules|DIETARY_SUPPLEMENT: Placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease
Status: ENROLLING_BY_INVITATION
Conditions: Inherited Mitochondrial Disease
Interventions: DRUG: Vatiquinone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulators of Gamma tACS in Alzheimer's Disease (Mod-GammAD)
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: Gamma tACS (40 Hz) over the superior parietal cortex|DEVICE: Sham tACS over the superior parietal cortex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of Jaundice in Newborns Using Smartphones
Status: COMPLETED
Conditions: Jaundice, Neonatal|Hyperbilirubinemia, Neonatal
Interventions: DEVICE: Bilirubin estimates from Smartphone Application|DIAGNOSTIC_TEST: Bilirubin concentration measured in standard blood samples|DEVICE: Bilirubin estimates from standard transcutaneous device|OTHER: Visual assessment of jaundice
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pharmacokinetics and Safety of the 100 Mcg Misoprostol Vaginal Insert (MVI 100)
Status: WITHDRAWN
Conditions: Cervical Ripening|Induction of Labor
Interventions: DRUG: Misoprostol Vaginal Insert (MVI 100)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Electrical Bioimpedance Assessments to Estimate Perioperative Total Body Water and Postoperative Fluid Need
Status: COMPLETED
Conditions: Intestinal Cancer|Diverticulitis|Pancreatic Cancer|Gastroesophageal Reflux Disease
Interventions: DEVICE: Bodystat Quadscan 4000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of tDCS Efficacy in Enduring Anorexia Nervosa
Status: TERMINATED
Conditions: Anorexia Nervosa
Interventions: DEVICE: transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Adjuvant Treatment With Capecitabine (Xeloda) in Combination With Oxaliplatin in Participants With Stage III Colon Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Capecitabine|BIOLOGICAL: Oxaliplatin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-antibiotic Prescribing for Acute Upper Respiratory Tract Infection
Status: WITHDRAWN
Conditions: Acute Upper Respiratory Tract Infection
Interventions: DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Course Regimens for Treatment of PKDL (Sudan)
Status: UNKNOWN
Conditions: PKDL - Post-Kala-Azar Dermal Leishmanioid
Interventions: DRUG: Paromomycin|DRUG: Ambisome|DRUG: Miltefosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting Study of Levothyroxine Sodium Tablets 300 μg to Synthroid® Tablets 300 μg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Levothyroxine Sodium Tablets 300 μg|DRUG: Synthroid® Tablets 300 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cleft Palate With Intravelar Veloplasty Repair
Status: COMPLETED
Conditions: Cleft Palate
Interventions: PROCEDURE: Repair of cleft palate with intravelar veloplasty (IVVP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: micafungin|DRUG: posaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vagal Stimulation in POTS
Status: ACTIVE_NOT_RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: DRUG: placebo sugar pill|DRUG: Pyridostigmine Pill|DRUG: Galantamine Pill|DEVICE: Vagal stimulation|DEVICE: Sham vagal stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Acetaminophen vs Placebo in the Pre-operative Setting and Outcomes on Post-operative Pain, Nausea and Vomiting
Status: TERMINATED
Conditions: Post Operative Pain|Post Operative Nausea and Vomiting
Interventions: DRUG: IV acetaminophen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Help With Early Detection of Postoperative Neuropathic Pain Using SMS After Ambulatory Surgery
Status: COMPLETED
Conditions: Chronic Postoperative Pain
Interventions: DIAGNOSTIC_TEST: SMS in the early detection of postoperative neuropathic pain
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SHR-1210 in Patients With Relapsed or Refractory Extranodal NK/T Cell Lymphoma
Status: UNKNOWN
Conditions: Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions: DRUG: SHR-1210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopy-Assisted Transanal Endoscopy Rectosigmoid Resection for Rectal Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Rectum
Interventions: PROCEDURE: Transanal endoscopic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Salvage Trial of AR Inhibition With ADT and Apalutamide With Radiation Therapy Followed by Docetaxel in Men With PSA Recurrent Prostate Cancer After Radical Prostatectomy (STARTAR)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Apalutamide|DRUG: Androgen deprivation|RADIATION: Salvage radiation therapy|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Anti-KIR in Smoldering Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma|Myeloma|Smoldering Multiple Myeloma
Interventions: DRUG: (Anti-KIR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAVI in Intermediate Risk Septuagenarians With Risk Factors Not Captured by the Traditional Surgical Risk Scores
Status: RECRUITING
Conditions: Transcatheter Aortic Valve Replacement
Interventions: DEVICE: Transcatheter Aortic Valve Implantation (TAVI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-954 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-954|DRUG: TAK-954 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Rosuvastatin on Triglyceride Levels in Mexican Hypertriglyceridemic Patients
Status: COMPLETED
Conditions: Hypertriglyceridemia|Hyperlipoproteinemia Type IV|Hyperlipoproteinemia Type V|Hyperlipoproteinemia Type IIb|Hyperlipidemia
Interventions: DRUG: rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Testing the Effectiveness of The Welcome Basket Intervention
Status: COMPLETED
Conditions: Psychosis
Interventions: BEHAVIORAL: Welcome Basket (WB)|BEHAVIORAL: Welcome Basket Brief (WBbr)|BEHAVIORAL: Treatment As Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Microbiota, Metabolome, and Environmental Toxins in Relation to Reproductive Health in Rwandan Women
Status: COMPLETED
Conditions: Vulvovaginal Candidiasis|Bacterial Vaginosis
Interventions: BIOLOGICAL: Lactobacillus GR-1 and Lactobacillus RC-14 oral capsules|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: In-vivo Wettability Grading and Assessment Study
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: lotrafilcon B|DEVICE: balafilcon A|DEVICE: senofilcon A|DEVICE: enfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Lidocaine in Ovarian Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer|Post Operative Pain
Interventions: PROCEDURE: intraperitoneal lidocaine analgesic or normal saline as control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
Status: COMPLETED
Conditions: Spontaneous Abortion in First Trimester
Interventions: DRUG: Vaginal Misoprostol|DRUG: Buccal Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy and Safety Evaluation of Co-administered HGP0904, HGP0608 and HGP0816 in Patients With Hypertension and Dyslipidemia
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: HGP0904|DRUG: HGP0608|DRUG: HGP0816|DRUG: HGP0904 Placebo|DRUG: HGP0816 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
Status: NOT_YET_RECRUITING
Conditions: Asthma in Children|Obesity|Pediatric Obesity|Pediatric Asthma
Interventions: DEVICE: Pro2 - Low Dose - 40% of participant's MIP|DEVICE: Pro2 - High Dose - 75% of participant's MIP|DEVICE: Pro2 - SHAM - 15% of participant's MIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP7713 in Healthy Non-Japanese Adult and Elderly Subjects and Healthy Japanese Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ASP7713|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Amnion Membrane Versus DFGG Using the Tunneling Technique in Management of Gingival Recession Defects.
Status: RECRUITING
Conditions: Gingival Recession
Interventions: PROCEDURE: Tunneling procedure with Amnion Membrane|PROCEDURE: Tunneling procedure with De-epithelialized Free Gingival Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2
Status: RECRUITING
Conditions: SCLC|Malignant Melanoma|Sarcoma
Interventions: DRUG: GD2-SADA:177Lu-DOTA Complex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation Programme in Workplaces in Hong Kong (Phase III)
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Health talk plus intensive social media intervention|BEHAVIORAL: Health talk plus less intensive social media intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Radiofrequency Interstitial Tissue Ablation in Treating Patients With Localized Renal Cell Carcinoma (Kidney Cancer)
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: PROCEDURE: laparoscopic surgery|PROCEDURE: radiofrequency ablation|PROCEDURE: thermal ablation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effect of Famotidine on the Drug Levels of BMS-986256 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986256|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma
Status: RECRUITING
Conditions: Plasma Cell Myeloma|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma|Smoldering Plasma Cell Myeloma
Interventions: BEHAVIORAL: Behavioral Intervention|DRUG: Beta-Adrenergic Antagonist|DRUG: Propranolol|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|OTHER: Resistance Training|OTHER: Short-Term Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Gene Modified Neuroblastoma Cells for the Treatment of Relapsed/Refractory Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: PROCEDURE: Skin Biopsy|GENETIC: Gene Modified Neuroblastoma Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visnadine, Prenylflavonoids and Bovine Colostrum to Treat Vulvovaginal Atrophy in Postmenopausal Women
Status: COMPLETED
Conditions: Vulvovaginal Atrophy|Menopause
Interventions: DRUG: Visnadine, prenylflavonoids and bovine colostrum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Baclofen for the Treatment of Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Baclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions
Status: COMPLETED
Conditions: Myopia|Hyperopia|Astigmatism
Interventions: DEVICE: RevitaLens OcuTec MPS (Investigational MPS) and Opti-Free RepleniSH MPS (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)
Status: COMPLETED
Conditions: Neurogenic Orthostatic Hypotension|Multiple System Atrophy (MSA) With Orthostatic Hypotension|Pure Autonomic Failure|Parkinson Disease|Hypotension, Orthostatic|Orthostatic Hypotension|Pure Autonomic Failure With Orthostatic Hypotension|Parkinson Disease With Orthostatic Hypotension
Interventions: DRUG: TD-9855|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplantation|Multiparametric Magnetic Resonance Imaging|Living Donors|Renal Fibrosis|Senescence
Interventions: PROCEDURE: Renal transplantation|PROCEDURE: Living kidney donation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Vitamin D Replacement on Airway Reactivity, Allergy and Inflammatory Mediators in Exhaled Breath Condensate in Vitamin D Deficient Asthmatic Children
Status: COMPLETED
Conditions: Asthma|Vitamin D Deficiency
Interventions: DRUG: Vitamin D3 as "BABY D3"|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Is TIme From adMission to surgEry an Independent Prognostic Factor for Survival of Patients With Gastro-intestinal Perforation Associated With Septic Shock: (TIME) An Italian Intersocietary Retrospective and Prospective Observational Trial
Status: UNKNOWN
Conditions: Emergency Surgery
Interventions: BEHAVIORAL: Surgical timing from ED admission to surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 2b Study of Modified Vaccinia Virus to Treat Patients Advanced Liver Cancer Who Failed Sorafenib
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Cancer|HCC
Interventions: BIOLOGICAL: JX-594 recombinant vaccina GM-CSF|OTHER: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iontophoretic Delivery of EGP-437 in Patients Who Have Undergone Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Anterior Chamber Inflammation|Pain, Postoperative
Interventions: COMBINATION_PRODUCT: Dexamethasone phosphate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalation Study of PHA-793887 in Patients With Advanced/Metastatic Solid Tumors
Status: TERMINATED
Conditions: Advanced/Metastatic Solid Tumors
Interventions: DRUG: PHA-793887
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidermal Cell Transplantation in Vitiligo Skin With and Without Narrow-band Ultraviolet B (UVB) Treatment
Status: COMPLETED
Conditions: Vitiligo
Interventions: RADIATION: UVB 311 nm radiation|DEVICE: UVB 311nm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2-year Follow-up After a Single Dose Acellular Pertussis Vaccination
Status: COMPLETED
Conditions: Pertussis
Interventions: BIOLOGICAL: Pertagen (aP BioNet)|BIOLOGICAL: Boostagen (TdaP BioNet)|BIOLOGICAL: Adacel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fludarabine in Combination With Daunorubicin and Cytarabine Liposome in Newly-diagnosed Acute Myeloid Leukemia.
Status: TERMINATED
Conditions: Acute Myeloid Leukemia, Adult|AML|AML, Adult
Interventions: DRUG: Fludarabine|DRUG: Vyxeos
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Intensity His Bundle Pacing in Heart Failure Patients With Narrow QRS Outcome Study
Status: RECRUITING
Conditions: Cardiac Conduction System|His Bundle Pacing|Heart Failure|Cardiomyopathies
Interventions: DEVICE: High Intensity His Bundle pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fish Oil and HMB Supplementation in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DIETARY_SUPPLEMENT: Capsule + Powder supplementation|OTHER: stable tracer infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Central Nervous System Efficacy of Capmatinib in NSCLC With Brain Metastases With cfDNA Positive MET Alterations
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Capmatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concentration- Versus Body Surface Area-based HIPEC in Colorectal Peritoneal Carcinomatosis' Treatment
Status: UNKNOWN
Conditions: Colorectal Peritoneal Carcinomatosis
Interventions: DRUG: Oxaliplatin: BSA-based HIPEC|DRUG: Oxaliplatin: Concentration-based HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tobramycin 300 mg Once-a-day (o.d.) Aerosol in Adults With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: tobramycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nintedanib as Switch Maintenance Treatment of Pleural Malignant Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Nintedanib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Alogliptin in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Alogliptin|DRUG: Alogliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ascending Dose Study of the Safety of AB-SA01 When Topically Applied to Intact Skin of Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: AB-SA01 (10^8 PFU per phage)|BIOLOGICAL: AB-SA01 (10^9 PFU per phage)|BIOLOGICAL: Placebo (for Cohort 10^8)|BIOLOGICAL: Placebo (for Cohort 10^9)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study of the Safety and Tolerability of the Addition of CHR-2797 to Paclitaxel in Patients With Advanced or Refractory Tumours
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: CHR-2797
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory, Open-Label, Oligo-Center Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Intravenous DNV3837 in Subjects With Clostridium Difficile Infection
Status: UNKNOWN
Conditions: Clostridium Difficile (C. Difficile)
Interventions: DRUG: DNV3837
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients
Status: COMPLETED
Conditions: Anemia, Iron-Deficiency|Kidney Failure, Chronic
Interventions: DRUG: Sodium Ferric Gluconate Complex in Sucrose Injection|DRUG: Ferrous sulfate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Equivalence Study of HCP0910 250/50 Mcg to Seretide 250 Diskus in Asthmatic Patients
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: HCP0910|DRUG: Seretide Diskus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT