pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Preventing Stroke Triggers in Children With Sickle Cell Anaemia in Mulago Hospital, Kampala (PREST ): a Randomized Control Trial
Status: UNKNOWN
Conditions: Preventing Stroke in Sickle Cell Anaemia
Interventions: BIOLOGICAL: Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test
Status: COMPLETED
Conditions: Colo-rectal Cancer|Cancer Colon|Cancer, Rectum|Neoplasms,Colorectal|Polyps|Polyp of Colon|Adenoma|Adenoma Colon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multidimensional Assessment and Intervention for Elder Self-Neglect
Status: COMPLETED
Conditions: Self-Neglect|Cognitive Ability, General|Geriatric Disorder
Interventions: OTHER: Comprehensive Geriatric Assessment and APS Usual Care|OTHER: APS usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lung Transplant READY CF 2: A Multi-site RCT
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: BEHAVIORAL: Investigator-designed lung transplant education resource (Research Intervention)|BEHAVIORAL: Publicly available transplant education resource (Attention-control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ITI-007 for the Treatment of Agitation in Patients With Dementia, Including Alzheimer's Disease
Status: TERMINATED
Conditions: Agitation in Dementia, Including Alzheimer's Disease
Interventions: DRUG: ITI-007|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Interrupting Sedentary Time With Different Frequencies of Physical Activity on Cardiometabolic Risk Factors
Status: ENROLLING_BY_INVITATION
Conditions: Sedentary|Cardiometabolic Syndrome|Physical Activity
Interventions: BEHAVIORAL: Sedentary breaks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Nivolumab & Low Dose Ipilimumab for Stage III & Resected Stage IV Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Ipilumumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Neuroimaging Study of Open-label Placebo in Depressed Adolescents
Status: RECRUITING
Conditions: Depression
Interventions: BEHAVIORAL: Open Label Placebo with Rationale|BEHAVIORAL: Open Label Placebo without Rationale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.
Status: COMPLETED
Conditions: Carcinoma|Carcinoma, Renal Cell|Neuroendocrine Tumors|Carcinoid Tumor|Pancreatic Islet Cell Tumors
Interventions: OTHER: Blood sampling by vena punction.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Smoking Reduction or Cessation by Means of no Nicotine Electronic Cigarette Added to Standard Counselling.
Status: COMPLETED
Conditions: Cancer|Myocardial Infarction
Interventions: DEVICE: No nicotine electronic cigarette|OTHER: Standard counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Accuracy of the Stepped Screening Protocol and Its Screening Tools in the Perinatal Period.
Status: RECRUITING
Conditions: Depressive; Episode, Major|Depression, Postpartum|Anxiety Disorders|Obsessive-Compulsive Disorder|Posttraumatic Stress Disorder
Interventions: DIAGNOSTIC_TEST: SCID 5
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cadonilimab Plus Regorafenib and Gem-Cis Chemotherapy in Advanced Biliary Tract Cancer
Status: RECRUITING
Conditions: Advanced Biliary Tract Cancer
Interventions: DRUG: Cadonilimab+Regorafenib+GC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREVENT HPV-Related Cancers
Status: NOT_YET_RECRUITING
Conditions: Vaccine Hesitancy|HPV Vaccination|Vaccine; Uptake|Vaccination; Series Completion|Vaccine Refusal
Interventions: BEHAVIORAL: PREVENT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Determine the Safety and Dose of EN001 in Patients With Charcot-Marie-Tooth Disease (CMT) Type 1A
Status: COMPLETED
Conditions: Charcot-Marie-Tooth Disease, Type IA
Interventions: DRUG: EN001|DRUG: EN001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B
Status: COMPLETED
Conditions: Meningitis, Cryptococcal|HIV Infections
Interventions: DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Novel Drug for Borderline Personality Disorder
Status: RECRUITING
Conditions: Borderline Personality Disorder
Interventions: DRUG: NMDA receptor antagonist (active drug)|OTHER: Lactose packed capsule (inert/inactive arm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of NA Combined With PEG-IFN-α2b in the Continuous Versus Pulsed Treatment of Patients With Chronic Hepatitis B
Status: RECRUITING
Conditions: Hepatitis B, Chronic
Interventions: DRUG: PEGylated recombinant human interferon alpha-2b injection|DRUG: PEGylated recombinant human interferon alpha-2b injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propofol Versus Dexmedetomidine for Prevention of Sevoflurane Agitation in Recipients of Living Donor Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation
Interventions: DRUG: Propofol|DRUG: dexmedetomedine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Food Composition on Postprandial Insulin Secretion in Neonatal Diabetes
Status: COMPLETED
Conditions: Neonatal Diabetes
Interventions: OTHER: High protein meal|OTHER: High carbohydrate meal|DRUG: Paracetamol|OTHER: Fasting state - sulphonylurea only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Efficacy, Safety, and Tolerability of Serlopitant for Pruritus (Itch) in Atopic Dermatitis
Status: COMPLETED
Conditions: Pruritus|Atopic Dermatitis
Interventions: DRUG: Serlopitant High Dose|DRUG: Placebo Oral Tablet|DRUG: Serlopitant Low Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for the Validation of AR Based Neuronavigation System
Status: RECRUITING
Conditions: Brain Neoplasms|Cerebral Aneurysm|Cerebral Arteriovenous Malformation|Navigation, Spatial
Interventions: DIAGNOSTIC_TEST: AR-based navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Trial of Devimistat in Combination With Modified FOLFIRINOX in Patients With Metastatic Adenocarcinoma of the Pancreas
Status: WITHDRAWN
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Devimistat|DRUG: Modified FOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pre-warming on Perioperative Hypothermia During HoLEPunder Spinal Anesthesia
Status: COMPLETED
Conditions: Hypothermia
Interventions: OTHER: pre-warming|OTHER: no warming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Compare Influence of Breakfast With and Without Sweeteners on Postprandial Glycemic Response and Appetite-Satiety Sensation in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: OTHER: Test food breakfast with NCS or witout NCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Effect of a Ghrelin Receptor Agonist on Muscle and Bone
Status: COMPLETED
Conditions: Sarcopenia|Osteopenia
Interventions: DRUG: Anamorelin Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis
Status: RECRUITING
Conditions: Nephrocalcinosis|Renal Calculi|Hypercalciuria|Hyperparathyroidism|Cystinuria
Interventions: OTHER: videotape for mapping of renal anatomy and papillary biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: VITAL - VAP Prevention by BIP (Bactiguard Infection Protection) ETT Evac in Belgian ICUs
Status: COMPLETED
Conditions: Ventilator-associated Pneumonia
Interventions: DEVICE: ETTEvac|DEVICE: BIP ETTEvac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Mode of Administration and Safety of EUR-1008 (APT-1008) in Infants 1 to 12 Months of Age
Status: COMPLETED
Conditions: Cystic Fibrosis|Exocrine Pancreatic Insufficiency
Interventions: DRUG: EUR-1008 (APT-1008)|DRUG: EUR-1008 (APT-1008)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study in Healthy Men Tests How the Body Takes up BI 1467335
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1467335|DRUG: BI 1467335 (C-14) intravenous solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Moderate-to-Severe Atopic Dermatitis
Interventions: DRUG: Nemolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants
Status: COMPLETED
Conditions: Pneumococcal Immunisation|Diphtheria Immunisation|Tetanus Immunisation|Pertussis Immunisation|Hepatitis B Immunisation|Haemophilus Influenzae Type b Immunisation|Polio Immunisation|Measles Immunisation|Rubella Immunisation|Varicella Immunisation|Mumps Immunisation
Interventions: BIOLOGICAL: Pneumococcal Conjugate Vaccine formulation 1|BIOLOGICAL: Pneumococcal Conjugate Vaccine formulation 2|BIOLOGICAL: Pneumococcal Conjugate Vaccine formulation 3|BIOLOGICAL: Varicella Virus Vaccine Live|BIOLOGICAL: Measles, Mumps, and Rubella Virus Vaccine Live|BIOLOGICAL: Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]|BIOLOGICAL: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate)|BIOLOGICAL: Rotavirus Vaccine, Live, Oral, Pentavalent|BIOLOGICAL: Hepatitis B Vaccine* [Recombinant] *as applicable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Plant Sterols on the Lipid Profile of Patients With Hypercholesterolaemia
Status: UNKNOWN
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Plant stanol esters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Goat Milk Yogurt on Postprandial Glycemic Responses, Arterial Blood Pressure and Energy Intake
Status: COMPLETED
Conditions: Potential Abnormality of Glucose Tolerance|Appetite; Lack or Loss, Nonorganic Origin
Interventions: OTHER: Glucose as reference food|OTHER: Goat milk as test food|OTHER: Goat milk and currants as test food|OTHER: Currants as test food|OTHER: Sultanina raisins as test food|OTHER: Goat milk yogurt as preload|OTHER: Milk with lactic acid as preload
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Development and Testing of a New Generation of Diabetic Footwear
Status: COMPLETED
Conditions: Diabetes Complications|Diabetic Neuropathies
Interventions: DEVICE: Footwear :PU|DEVICE: Footwear: MCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preemptive Treatment With Acyclovir in Intubated and Mechanically Ventilated Patients With Herpes (PTH2)
Status: NOT_YET_RECRUITING
Conditions: Invasive Mechanical Ventilation|HSV Throat Reactivation
Interventions: DRUG: Intravenous acyclovir (ACYCLOVIR )|DRUG: Saline bags
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Gastro-intestinal Tolerance of an Upgraded Composition of an Enteral Tube Feed for Adults
Status: COMPLETED
Conditions: Enteral Tube Nutrition
Interventions: DIETARY_SUPPLEMENT: Upgraded tube feed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparative Study Between Ultrasound Guided Erector Spinae Plane Block and Combined Ultrasound Guided Pericapsular Nerve Group and Lateral Femoral Nerve Block Following Total Hip Arthroplasty
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: PENG block|PROCEDURE: LFCN block|PROCEDURE: ESP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Serum Bovine Immunoglobulin Protein Isolate in Improving Quality of Life and Post-Operative Recovery in Patients With Gynecological Cancer After Undergoing Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Female Reproductive Cancer
Interventions: BIOLOGICAL: serum-derived bovine immunoglobulin protein isolate|OTHER: placebo|OTHER: laboratory biomarker analysis|OTHER: quality-of-life assessment|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Biobehavioral Efficacy of the Semi-Elevated Side-Lying Position
Status: COMPLETED
Conditions: Feeding, Bottle|Infant, Premature, Diseases|Behavior, Infant
Interventions: OTHER: Arm 1 - Side-lying position followed by Supine position|OTHER: Arm 2 - Supine position followed by Side-lying position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase II, Multicenter, Randomized, Placebo -Controlled, Study To Evaluate The Efficacy and Safety Of Intramuscular Peramivir 600 mg In Subjects With Uncomplicated Acute Influenza
Status: COMPLETED
Conditions: Acute, Uncomplicated Human Influenza
Interventions: DRUG: Peramivir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
Status: RECRUITING
Conditions: Cognitive Impairment|Bipolar Disorder|Depression
Interventions: OTHER: Altitude-like hypoxia (12% O2)|OTHER: Normoxia (20% O2)|BEHAVIORAL: Cognitive training|BEHAVIORAL: Sham training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study of the Differences in Characteristics of the Spontaneous Electroencephalogram, Derived From the Left and Right Hemisphere in Patients With Unilateral Intracranial Tumor During Routine Anesthesia: Comparison With a Control Group Without Intracranial Pathology
Status: COMPLETED
Conditions: Intracranial Tumor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Survivorship Care Plan for Gynaecological Cancer Patients
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Cervical Cancer|Endometrial Cancer|Esophageal Cancer|Fallopian Tube Cancer|Gastric Cancer|Ovarian Cancer|Sarcoma|Vaginal Cancer|Vulvar Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease
Status: COMPLETED
Conditions: Peri-Implantitis|Bone Loss in Jaw|Dental Implant Failed|Dental Implant Failure Nos|Oxidative Stress
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for SPMS of Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: NeuroVax|BIOLOGICAL: IFA Incomplete Freund's Adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study of the Safety and Efficacy of Entecavir in Pediatric Patients With Chronic Hepatitis B Virus Infection
Status: COMPLETED
Conditions: Chronic Hepatitis B Virus, Pediatric
Interventions: DRUG: Entecavir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COEBICS: Comparison of Erythema Between Interrupted and Continuous Sutures
Status: UNKNOWN
Conditions: Surgical Scar Erythema
Interventions: PROCEDURE: Superior/Medial Running Sutures|PROCEDURE: Inferior/Lateral Running Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetic Retinopathy: Effects of Melatonin Treatment on Visual Functions and Circadian Rhythm
Status: COMPLETED
Conditions: Diabetic Retinopathy|Melatonin|Circadian Dysrhythmia|Circadian Rhythm Sleep Disorder, Unspecified Type
Interventions: DRUG: Melatonin 4 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CoQ10 in Statin-associated Asthenia
Status: COMPLETED
Conditions: Hypercholesterolemia|Physical Performance
Interventions: DIETARY_SUPPLEMENT: Coenzyme Q10|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Brief, Online Intervention for Military Personnel
Status: COMPLETED
Conditions: Experimental|Placebo Contol
Interventions: BEHAVIORAL: Cognitive Anxiety Sensitivity Treatment|BEHAVIORAL: Physical Health Education Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)
Status: RECRUITING
Conditions: Breast|Metastatic|Triple Negative|Cancer|Disseminated Tumor Cell
Interventions: DRUG: Capecitabine|COMBINATION_PRODUCT: Sarilumab 150mg or 200 mg plus Capecitabine|COMBINATION_PRODUCT: Sarilumab 150mg plus Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase II Study of FOLFOX Versus FOLFIRI.3 in Gemcitabine-refractory Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: FOLFIRI.3|DRUG: FOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on Remote Ischemic Preconditioning and Cerebral Small Vessel Disease
Status: COMPLETED
Conditions: Cerebral Small Vessel Disease
Interventions: PROCEDURE: remote ischemic preconditioning|PROCEDURE: sham remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Infant HIV Treatment in Botswana
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV|Pediatric AIDS
Interventions: DRUG: Nevirapine|DRUG: Kaletra|DRUG: Lamivudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Daily Pro-Omega LDL for Low-Density Lipoprotein Cholesterol and Triglyceride Reduction
Status: WITHDRAWN
Conditions: Mixed Hyperlipoproteinemia
Interventions: DIETARY_SUPPLEMENT: Pro-Omega LDL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of CEA Targeting Chimeric Antigen Receptor T Lymphocytes（CAR-T） for CEA Positive Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Gastric Cancer|Colon Cancer|Rectal Cancer|Breast Cancer|Lung Cancer|Esophagus Cancer|Cholangiocarcinoma|Pancreas Cancer
Interventions: BIOLOGICAL: CEA-targeted CAR-T cells|BIOLOGICAL: CEA-targeted CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SCHEDULE Follow Up Visit 5-7 yr
Status: COMPLETED
Conditions: Heart Transplantation
Interventions: DRUG: Everolimus|DRUG: Cyclosporine|DRUG: Mycophenolate mofetil|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ANIMATOR - RehUP BCI Controlled Robotic Therapy vs. an Attention-based Control
Status: NOT_YET_RECRUITING
Conditions: Chronic Stroke
Interventions: DEVICE: RehUp BCI Intervention|OTHER: Control Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: DMARDs|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Index of Pastry
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Glucose|OTHER: truffle match|OTHER: hazelnut chocolate cookie|OTHER: Paris Brest style eclair|OTHER: hazelnut chocolate finger|OTHER: lemon finger|OTHER: elderflower madeleine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes Trial
Status: COMPLETED
Conditions: Dipeptidyl-Peptidase 4 Inhibitors|LDL Cholesterol|Glycosylated Hemoglobin|Diabetes Mellitus|Coronary Disease
Interventions: DRUG: Anagliptin|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Thrombosis Risk in Chemotherapy Patients With Solid Tumors Who Receiving Thrombocytopenia Treatment
Status: COMPLETED
Conditions: Chemotherapy-induced Thrombocytopenia
Interventions: DRUG: Recombinant Human Interleukin-11 for Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assess the Efficacy and Safety of Alefacept With Narrow Band Ultraviolet B Phototherapy (nbUVB) vs. Alefacept Alone in Chronic Plaque Psoriasis Subjects
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: alefacept|PROCEDURE: Narrow Band UVB Phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Absorption of Magnesium Oxide Compared to Citrate in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects|Hypomagnesemia
Interventions: DIETARY_SUPPLEMENT: Magnesium oxide|DIETARY_SUPPLEMENT: Magnesium citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Medium-Dose UVA1 Versus Narrow-Band UVB in Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: PROCEDURE: UVA1 phototherapy|PROCEDURE: NB-UVB phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sevoflurane and Propofol on Hepato-splanchnic Pressure and Flow During Hepatobiliary Surgery
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: Propofol Fresenius|DRUG: sevorane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Brain Electrophysiological Study(EEG/ERP) on Opiate Addicts Treating by Bilateral NAc/ALIC Deep Brain Stimulation
Status: UNKNOWN
Conditions: Substance-Related Disorders
Interventions: DEVICE: Emotional pictures stimulation system|PROCEDURE: Deep brain stimulation|PROCEDURE: adjacent contact stimulation|PROCEDURE: microelectrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of Integrative Treatment for Pediatric Community Acquired Pneumonia
Status: UNKNOWN
Conditions: Pneumonia
Interventions: DRUG: Xiyanping injection|DRUG: wind-heat formula granules|DRUG: phlegm-heat formula granules|DRUG: Fu-xiong San|DRUG: second generation cephalosporin|DRUG: Erythromycin|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Early Screening Test for Pre-eclampsia and Growth Restriction
Status: COMPLETED
Conditions: Pre-Eclampsia|Placenta Diseases|Eclampsia Preeclampsia|Fetal Growth Retardation|Foetal Growth Restriction
Interventions: DRUG: Low dose aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: STIP: Statin Trial for Influenza Patients
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome|Influenza|H1N1 Influenza
Interventions: DRUG: Rosuvastatin (crestor)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep-disordered Breathing in Infants With Myelomeningocele
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep-disordered Breathing|Myelomeningocele
Interventions: DIAGNOSTIC_TEST: neonatal polysomnography|DIAGNOSTIC_TEST: 2-year Bayley Exam|DIAGNOSTIC_TEST: 2-year polysomnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Double-Blind Follow-on Safety Study of HZT-501 (Ibuprofen 800 mg/Famotidine 26.6 mg) in Subjects Who Have Completed Participation in HZ-CA-301 (NCT00450658) or HZ-CA-303 (NCT00450216)
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Chronic Low Back Pain|Chronic Regional Pain Syndrome|Chronic Soft Tissue Pain
Interventions: DRUG: HZT-501|DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Profile and Dermatomal Coverage of the Erector Spinae Plane Block
Status: WITHDRAWN
Conditions: Pain, Postoperative|Pain, Chest
Interventions: DRUG: Ropivacaine 0.25%-NaCl 0.9% Injectable Solution|DRUG: Ropivacaine 0.2%-NaCl 0.9% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Precancerous/Nonmalignant Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: carboplatin|DRUG: docetaxel|DRUG: ifosfamide|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate Safety and Tolerability of NoNO-42 in Healthy Adults
Status: COMPLETED
Conditions: First-In-Human Study to Evaluate Safety of a New Drug Intended for Treatment of Acute Ischemic Stroke
Interventions: DRUG: NoNO-42|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Management of Constitutional Thinness Through an Adapted Physical Activity Program, Whether or Not Associated With Food Supplementation. Interventional Study Compared to Matched Controls: NUTRILEAN + Study
Status: UNKNOWN
Conditions: Healthy Normal Weight Women|Constitutionally Lean Women
Interventions: BEHAVIORAL: Physical training alone|BEHAVIORAL: physical training + protein intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Obese Human Beta-2-adrenergic Stimulation and Muscle Glucose Uptake
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Clenbuterol Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Xtampza ER to Overcome Difficulties in Swallowing Opioid Pills
Status: TERMINATED
Conditions: Chronic Pain|Opioid Use|Deglutition
Interventions: DRUG: Xtampza ER (oxycodone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intra-individual Comparison of Conventional and Digital PET/CT Scanners
Status: COMPLETED
Conditions: Breast Cancer|Lung Cancer|Esophageal Cancer|Miscellaneous Neoplasm
Interventions: DIAGNOSTIC_TEST: Digital PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia
Status: COMPLETED
Conditions: Arthralgia|Arthritis
Interventions: DRUG: Abatacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LY231514 in Treating Patients With Locally Advanced or Metastatic Solid Tumors and Varying Degrees of Kidney Function
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: pemetrexed disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Antibiotics After Cesarean
Status: COMPLETED
Conditions: Surgical Site Infection
Interventions: DRUG: Cephalexin|DRUG: Placebo|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictive Response to Chemotherapy (FOLFOX or FOLFIRI) by ex Vivo Culture 3D Technique in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: biopsy to obtain a chemogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Antidepressant Trial With P2X7 Antagonist JNJ-54175446
Status: UNKNOWN
Conditions: Depressive Disorder, Major|Inflammation
Interventions: DRUG: Active JNJ-54175446|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction
Status: COMPLETED
Conditions: Heart Disease|Heart Failure With Preserved Ejection Fraction|Exercise Intolerance|Pulmonary Hypertension
Interventions: DRUG: Nitrite|DRUG: Saline Placebo for Nitrite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Best Assessment of Sore Throat and Antibiotic Prescribing
Status: RECRUITING
Conditions: Pharyngitis
Interventions: BEHAVIORAL: Physicians assess patients|BEHAVIORAL: Nurses assess patients|BEHAVIORAL: Pharmacists assess patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Effect Between Salsalate and Placebo in Osteoarthritis With Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non Alcoholic Fatty Liver|Osteo Arthritis
Interventions: DRUG: Salsalate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxygen Supplementation During Bronchoscopy: High Flow Versus Low Flow Oxygen
Status: UNKNOWN
Conditions: Hypoxia
Interventions: DEVICE: High flow nasal oxygen supplementation|DEVICE: low flow nasal oxygen supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of Aloe Vera in the Management of the Symptoms of Interstitial Cystitis
Status: NOT_YET_RECRUITING
Conditions: Interstitial Cystitis|Chronic Interstitial Cystitis|Bladder Pain Syndrome
Interventions: DRUG: Desert Harvest Aloe Vera Capsules|OTHER: Placebo Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Gut Microbiota and Prebiotic Response
Status: COMPLETED
Conditions: Healthy Gut Microbiota
Interventions: DIETARY_SUPPLEMENT: Prebiotic A - inulin|DIETARY_SUPPLEMENT: Prebiotic B - galactooligosaccharides(GOS)|DIETARY_SUPPLEMENT: Prebiotic C - wheat dextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cardiotoxicity Prevention in Breast Cancer Patients Treated With Anthracyclines and/or Trastuzumab
Status: UNKNOWN
Conditions: Breast Cancer|Cardiotoxicity
Interventions: DRUG: Bisoprolol|DRUG: Ramipril|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Feasibility of the AveCure Microwave Ablation Technology for the Bronchoscopic Treatment of Malignant Central Airway Obstructions
Status: RECRUITING
Conditions: Airway Obstruction|Central Airway Obstruction
Interventions: DEVICE: AveCure Flexible Microwave Ablation Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Immunogenicity of AERAS-402 Administered in HIV-negative, BCG-vaccinated, QFT (+) and (-) Adults Without Evidence of TB
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: AERAS-402
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Replacement Therapy With Sexual Steroid Hormones on the Insulin Sensitivity of Hypogonadal Man
Status: COMPLETED
Conditions: Hypogonadism
Interventions: BIOLOGICAL: Estradiol (Insulin sensitivity)|BIOLOGICAL: Testosterone (Insulin sensitivity)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Desflurane,Brain Natriuretic Peptide and Cardiac Surgery
Status: COMPLETED
Conditions: Brain Natriuretic Peptide|Coronary Artery Bypass Graft Surgery|Cardiac Surgery|Cardiopulmonary Bypass|Desflurane|Outcome
Interventions: DRUG: Desflurane Inhalational agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neurobehavioral Mechanisms of Cocaine Choice
Status: RECRUITING
Conditions: Cocaine Use Disorder
Interventions: DRUG: Sustained Release d-amphetamine|BEHAVIORAL: Money
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase Ib/II Clinical Study of LBL-007 in Treatment of Advanced Malignant Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: LBL-007 Injection|DRUG: Toripalimab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Probiotics for Reducing Infections in Veterans: The IMPROVE Study
Status: COMPLETED
Conditions: Anti-biotic Resistance
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus HN001|DIETARY_SUPPLEMENT: sugar pill (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness and Safety of Intravesical Docetaxel Instillation for Prevent Bladder Recurrence
Status: UNKNOWN
Conditions: Urothelial Carcinoma
Interventions: DRUG: Docetaxel|DRUG: Placebo Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sensory Processing in Tourette Syndrome
Status: COMPLETED
Conditions: Tourette Syndrome
Interventions: OTHER: The Sensory Profile|OTHER: The Adult/Adolescent Sensory Profile|OTHER: Children's Yale-Brown Obsessive Compulsive Scale|OTHER: Yale-Brown Obsessive Compulsive Scale|OTHER: Yale Global Tic Severity Scale|OTHER: Demographic Data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Behavioral and Neurofunctional Correlates of Intentional Motor Behaviors Towards Edible Stimuli in Normal-weight Subjects
Status: UNKNOWN
Conditions: Food Oriented Behavior
Interventions: OTHER: Neurofunctional imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: AUD Biomarkers Study (Proteomic and Genomic Analysis of Biospecimens)
Status: ENROLLING_BY_INVITATION
Conditions: Oncology|Hematologic Malignancy|Gastro-Intestinal Disorder|Autoimmune Diseases|Pregnancy Related|Infectious Disease|Cardiovascular Diseases|Genitourinary Disease|Renal Disease
Interventions: OTHER: Observational Study Only. NO Intervention.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Neoplasms
Interventions: BIOLOGICAL: Durvalumab|BIOLOGICAL: Cetuximab|RADIATION: Intensity modulated radiation therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thiamine and Acute Decompensated Heart Failure: Pilot Study
Status: COMPLETED
Conditions: Heart Failure|Diabetes
Interventions: DRUG: Thiamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect on Overall Mortality of a National Policy of Limiting Measles Vaccination to Children Below 12 Months of Age
Status: COMPLETED
Conditions: Mortality|Vaccines
Interventions: BIOLOGICAL: Providing measles vaccine for all children 9-35 months who have not yet received a routine measles vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Xiangjurupining Capsule in the Treatment of Hyperplasia of Breast (Liver Stagnation and Phlegm Coagulation)
Status: COMPLETED
Conditions: Hyperplasia of Breast
Interventions: DRUG: High dose Xiang Ju Ru Pi Ning capsule|DRUG: Low dose Xiang Ju Ru Pi Ning capsule|DRUG: Xiang Ju Ru Pi Ning capsule placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea in Patients Requiring Anterior Lamellar Keratoplasty
Status: COMPLETED
Conditions: Leukoma
Interventions: DEVICE: RHCIII-MPC cornea|DEVICE: Donor cornea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Cleft Lip and Palate
Interventions: DEVICE: Naso-alveolar molding (NAM)|DEVICE: Computer aided design NAM (CAD/NAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasonography of Chest Versus Pulmonary Artery CT Angiography in Patients With Symptoms and Signs in Favor of PTE
Status: UNKNOWN
Conditions: Pulmonary Thromboembolism
Interventions: OTHER: Pulmonary artery CT Angiography|OTHER: Emergency Bedside Ultrasonography of chest
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Hepatic Impairment Study For Crizotinib In Advanced Cancer Patients
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: crizotinib|DRUG: crizotinib|DRUG: crizotinib|DRUG: crizotinib|DRUG: crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PEP-DC and OC-DC Vaccine in High Grade Serous Ovarian Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Ovarian Carcinoma
Interventions: BIOLOGICAL: PEP-DC1|BIOLOGICAL: OC-DC|BIOLOGICAL: PEP-DC2|DRUG: Low dose cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Acalabrutinib|DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BPZE1 Intranasal Pertussis Vaccine (Administered Via VaxINator(TM)), Prime + Boost, in Healthy Adults
Status: COMPLETED
Conditions: Pertussis|Whooping Cough
Interventions: COMBINATION_PRODUCT: BPZE1 pertussis vaccine and VaxINator(TM) Atomization Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of 3D Heart Modelling on Family Quality of Life and Surgical Success
Status: NOT_YET_RECRUITING
Conditions: Congenital Heart Disease
Interventions: OTHER: Surgical Simulation with 3D Heart Model and Parental Education with "Congenital Heart Disease Parent Education Booklet" and tailored 3D Heart Modeling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER