pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy of FSD201 for the Treatment of Chronic Pain Associated With Idiopathic MCAS (MCAD)
Status: TERMINATED
Conditions: Mast Cell Activation Syndrome|Mast Cell Activation Disorder Idiopathic
Interventions: DRUG: FSD201|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: hyperpolarized 129Xe gas MRI|DRUG: Bevespi Aerosphere
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacokinetic Study Comparing SCT400 And Rituximab in Patients With B-cell Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: B-cell Non Hodgkin's Lymphoma
Interventions: DRUG: SCT400|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Belimumab in Subjects With Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: belimumab|BIOLOGICAL: belimumab|BIOLOGICAL: belimumab|BIOLOGICAL: belimumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adapting and Evaluating a Tobacco Use Cessation Program for People Living With HIV in Uganda and Zambia
Status: RECRUITING
Conditions: Nicotine Dependence|Tobacco Dependence
Interventions: DRUG: Nicotine patch|BEHAVIORAL: text messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Lymphocyte Subpopulations in the Normal Mucosa of the Upper Digestive Tract
Status: UNKNOWN
Conditions: Lymphocytic Enteritis (Disorder)|Healthy Volunteers
Interventions: OTHER: Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study Using Bevacizumab, Capecitabine and Oxaliplatin for Colorectal Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vantictumab (OMP-18R5) in Combination With Docetaxel in Patients With Previously Treated NSCLC
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Docetaxel|DRUG: vantictumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Intervention on Hope, Anxiety, and Attitudes and Behavioral Intentions of Advance Care Planning in Older Adults With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advance Care Planning
Interventions: BEHAVIORAL: Handbook for Geriatric Prearranged Medical Care Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigating the Absorption, Metabolism and Excretion (AME) of Idalopirdine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: [ethyl-1-14C]-idalopirdine|DRUG: [benzyl-7-14C]-idalopirdine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum
Status: COMPLETED
Conditions: Infections|Vector Borne Diseases|Systemic Inflammatory Response Syndrome|Inflammation|Pathologic Processes|Malaria|Malaria,Falciparum|Parasitemia|Parasitic Diseases|Protozoan Infections|Antimalarials|Anti-Infective Agents
Interventions: DRUG: MMV367|OTHER: P. falciparum IBSM infection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of Different Doses of AG019 Administered Alone or in Combination With Teplizumab in Participants With Recent-onset Diagnosed Type 1 Diabetes (T1D)
Status: COMPLETED
Conditions: Diabetes type1
Interventions: BIOLOGICAL: AG019 - Low Dose|DRUG: Teplizumab|DRUG: Placebo-AG019|DRUG: Placebo-Teplizumab|BIOLOGICAL: AG019 - High Dose|BIOLOGICAL: AG019 - High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral/Intramuscular B12 to Treat Cobalamin Deficiency
Status: COMPLETED
Conditions: Vitamin B 12 Deficiency
Interventions: DRUG: oral Cobalamin (vitamin B12)|DRUG: intramuscular Cobalamin (vitamin B12)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Prevalence Of Sacroiliac Joint Dysfunction In Patients With Lumbar Disc Hernia
Status: COMPLETED
Conditions: Lumbar Disc Herniation|Sacroiliac Joint Dysfunction
Interventions: OTHER: Evaluation of the prevalence of sacroiliac joint dysfunction in lumbar disc herniation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Complications and Functional Outcome of Displaced Femoral Neck Fractures in Patients Younger Than 70 Years
Status: COMPLETED
Conditions: Femoral Neck Fractures|Osteoporosis
Interventions: PROCEDURE: Total hip replacement arthroplasty|PROCEDURE: Closed reduction and internal fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Catheter Evaluation for Endocardial Ablation in Patients With Ventricular Tachycardia
Status: COMPLETED
Conditions: Ventricular Tachycardia
Interventions: DEVICE: NAVISTAR® THERMOCOOL® Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Neuromuscular Blockade Monitors
Status: RECRUITING
Conditions: Neuromuscular Blockade
Interventions: DEVICE: Mechanomyograph Twitch Monitor|DEVICE: Stimpod Twitch Monitor|DEVICE: TetraGraph Twitch Monitor|DEVICE: TwitchView Twitch Monitor|DEVICE: Nihon Kohden Twitch Monitor|OTHER: Palpation of twitch count
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of the Optilume™ BPH Catheter System in Men With Symptomatic BPH
Status: ACTIVE_NOT_RECRUITING
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Optilume BPH Catheter System|DEVICE: Optilume Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corticosteroid Rhythms in Hypoparathyroid Patients
Status: UNKNOWN
Conditions: Hypoparathyroidism|Hyperparathyroidism
Interventions: DRUG: parathyroid hormon 1-84
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in Children With Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: Hydroxycarbamid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: High-definition Cathodal Transcranial Direct Current Stimulation (HD C-tDCS)|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Sebaceous Hyperplasia With PDL and Nd:YAG Versus Erbium:YAG: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Sebaceous Hyperplasia
Interventions: DEVICE: Erbium:YAG Laser|DEVICE: Pulsed Dye Laser|DEVICE: Nd:YAG Laser|PROCEDURE: Electrodessication and curettage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thrombin Generation Parameters and Bleeding in Patients Treated With Anticoagulants for Cancer Associated Thrombosis
Status: NOT_YET_RECRUITING
Conditions: Cancer|Pulmonary Embolism|Thrombosis
Interventions: BIOLOGICAL: Thrombin Generation Assay (TGA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Different Types of Carbohydrates in Snacks and Beverages on Glycemia, Insulinemia and Appetite.
Status: COMPLETED
Conditions: Pre Diabetes|Obesity
Interventions: OTHER: Soluble corn fiber|OTHER: maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Effects of Eccentric Muscle Training Versus Conventional Concentric Training in Chronic Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure|Reconditioning to Effort
Interventions: OTHER: initial evaluation|OTHER: Period of cardiac rehabilitation|OTHER: final evaluation|OTHER: Concentric and eccentric exercise sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Relative Bioavailability/Bioequivalence of Different Formulations of Selinexor, the Impact of Hepatic Impairment on Selinexor Pharmacokinetics, Tolerability and Antitumor Activity of Selinexor Combination Treatment
Status: RECRUITING
Conditions: Non-Small Cell Lung Carcinoma (NSCLC)|Colorectal Cancer (CRC)|Other Solid Tumors
Interventions: DRUG: Selinexor 100 mg|DRUG: Docetaxel|DRUG: Pembrolizumab|DRUG: FOLFIRI|DRUG: Selinexor 40 mg|DRUG: Selinexor 80 mg|DRUG: Selinexor 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensory Re-Training Following Facial Surgery for Correction of Facial Skeletal Disharmony
Status: COMPLETED
Conditions: Mandibular Advancement
Interventions: BEHAVIORAL: Sensory Re-training|BEHAVIORAL: Sensory Retraining|BEHAVIORAL: Opening Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of the Toll-like Receptor 7-agonist Imiquimod 3.75% as a New Surrogate Model of Itch
Status: WITHDRAWN
Conditions: Itch
Interventions: DRUG: Zyclara 3.75 % Topical Cream|DRUG: Prudoxin|OTHER: Histamine|OTHER: Cowhage|OTHER: L-menthol|OTHER: Trans-cinnamaldehyde (CA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Stress Ball on Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Quality of Life|Depression|Anxiety|Stress
Interventions: OTHER: Stress ball practice group (Stress ball squeezing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of High Intensity Focused Ultrasound (HIFU) Device to Treat Secondary Hyperparathyroidism
Status: WITHDRAWN
Conditions: Secondary Hyperparathyroidism|End Stage Renal Disease|Parathyroid Hyperplasia
Interventions: DEVICE: Ultrasonic ablation device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Effect of Azasite on Corneal Surface Irregularity
Status: WITHDRAWN
Conditions: Meibomian Gland Dysfunction
Interventions: DRUG: Azasite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics Study of Turoctocog Alfa Pegol Injected Under the Skin in Patients With Haemophilia A
Status: COMPLETED
Conditions: Congenital Bleeding Disorder|Haemophilia A
Interventions: DRUG: turoctocog alfa pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teverelix Evaluated in Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Adenoma
Interventions: DRUG: teverelix TFA 120 mg|DRUG: teverelix TFA 180 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Drug Interaction Between Rosuvastatin and Valsartan
Status: COMPLETED
Conditions: Hypertension|Hyperlipidemia
Interventions: DRUG: Rosuvastatin+Valsartan (Sequence 1)|DRUG: Rosuvastatin+Valsartan (Sequence 2)|DRUG: Rosuvastatin+Valsartan (Sequence 3)|DRUG: Rosuvastatin+Valsartan (Sequence 4)|DRUG: Rosuvastatin+Valsartan (Sequence 5)|DRUG: Rosuvastatin+Valsartan (Sequence 6)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Lightweight Nasal Interface and Ventilator in Patients With Respiratory Disease
Status: UNKNOWN
Conditions: Chronic Obstructive Lung Disease|Interstitial Lung Disease
Interventions: DEVICE: Tidal Assist Ventilator System|DEVICE: Nasal Cannula Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Duloxetine for Multiple Sclerosis Pain
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Duloxetine Hydrochloride (HCI)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Goal-directed Volume Resuscitation in Severe Acute Pancreatitis
Status: COMPLETED
Conditions: Acute Pancreatitis
Interventions: OTHER: PiCCO-parameter-guided volume resuscitation|OTHER: Control-group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Individualized Exercise Training Based on the Heart Rate Variability in Coronary Heart Disease Patient
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Standardized exercise training|OTHER: HRV-guided exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome
Status: UNKNOWN
Conditions: Painful Bladder Syndrome (PBS)
Interventions: DRUG: Intravesical injection of Botulinum A Toxin|PROCEDURE: Bladder overdistension|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Study of ALS-002200; Single Dose, Food Effect in Healthy Volunteers; Multiple Doses in Chronic Hepatitis C Genotype 1
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: ALS-002200|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RO5313534 as Add-on to Donepezil Treatment in Patients With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Placebo|DRUG: RO5313534|DRUG: RO5313534|DRUG: RO5313534
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improve Acute Reperfusion Treatment Quality for Stroke in China, IMPROVE: Stroke Care in China
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: BEHAVIORAL: improvement of quality of stroke care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oxygen Study-Orelabrutinib Combined With Obinutuzumab(O2) for First-Line Treatment of Marginal Zone Lymphoma
Status: RECRUITING
Conditions: Marginal Zone Lymphoma
Interventions: DRUG: Orelabrutinib, obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Selective Supraclavicular Nerve Block for Postoperative Pain Control in Pediatric Patients.
Status: COMPLETED
Conditions: Cancer Pediatric
Interventions: DRUG: Ropivacaine|OTHER: Control (without intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study
Status: COMPLETED
Conditions: Sleep Disordered Breathing|Obstructive Sleep Apnea|Snoring|Obstructive Sleep Disordered Breathing
Interventions: PROCEDURE: Adenotonsillectomy (AT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve Block
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Histone Deacetylase Inhibitor 4SC-202 in Patients With Advanced Hematologic Malignancies (TOPAS)
Status: COMPLETED
Conditions: Advanced Hematologic Malignancies
Interventions: DRUG: 4SC-202
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correction by ECCO2-R of Hypercapnia in Patients With DVP in Moderate to Severe ARDS Under Protective Ventilation.
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Hypercapnia
Interventions: DEVICE: Extracorporeal CO2 removal (ECCO2-R) (PrismaLung®, Prismaflex ® Baxter)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Find the Dose and Assess the Immune Response and Safety of a Vaccine Against Influenza in Healthy Younger and Older Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Flu Seasonal mRNA Formulation 1|BIOLOGICAL: Flu Seasonal mRNA Formulation 2|BIOLOGICAL: Flu Seasonal mRNA Formulation 3|BIOLOGICAL: Flu Seasonal mRNA Formulation 4|BIOLOGICAL: Flu Seasonal mRNA Formulation 5|BIOLOGICAL: Flu Seasonal mRNA Formulation 6|BIOLOGICAL: Flu Seasonal mRNA Formulation 7|BIOLOGICAL: Flu Seasonal mRNA Formulation 8|COMBINATION_PRODUCT: Active Comparator 1|COMBINATION_PRODUCT: Active Comparator 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biosimilarity Study of IM Injection of Human Chorionic Gonadotrophin After Parenteral Administration of Treatment A TEST Product Epifasi 5000 I.U. Ampoules (EIPICO PHARMA, EGYPT) and Treatment B REFERENCE Product Pregnyl 5000 I.U. Ampoules (Baxter Pharmaceutical Solutions for Organon, USA).
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DRUG: Epifasi: Human chorionic gonadotrophin|DRUG: Pregnyl: Human chorionic gonadotrophin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Laryngoscopic View With C-MAC Videolaryngoscope Miller Blade Lifting the Epiglottis or the Vallecula in Children
Status: COMPLETED
Conditions: Intubation|Laryngoscopy
Interventions: DEVICE: Videolaryngoscope size 1 Miller blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Pulsatile IV Insulin on Circulating Risk Markers of Vascular and Metabolic Complications in Pts With Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: Effect of Pulsatile IV insulin on diabetic pt blood markers|PROCEDURE: Effect of Pulsatile IV Insulin on blood markers|PROCEDURE: Effect of Pulsatile IV insulin on diabetic pt blood markers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Biofeedback vs. Botox Injection to Treat Levator Ani Syndrome
Status: UNKNOWN
Conditions: Levator Ani Syndrome With Pain and/or Constipation Symptoms.
Interventions: BEHAVIORAL: Biofeedback therapy|PROCEDURE: Botulinum Toxin Type A Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of a Customized Free-form Progressive Addition Lens Spectacle
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: Standard, non-free-form, non-customized PAL spectacles|DEVICE: Individually customized free-form surfaced PAL spectacles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Serious Game 'Broodles' for Siblings of Children With Visual Impairment and/or Intellectual Disability
Status: COMPLETED
Conditions: Healthy
Interventions: BEHAVIORAL: Serious game 'Broodles'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury
Status: COMPLETED
Conditions: Acute Lung Injury
Interventions: DRUG: Aspirin 75mg|DRUG: Lactose powder|DRUG: Aspirin 1200mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BioFeedBack Breathing Training Influence Cardiac Autonomic Nervous System in Children With Cerebral-Palsy.
Status: COMPLETED
Conditions: Cerebral Palsy|Autonomic Nerveus System
Interventions: OTHER: Biofeedback training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Malaria During Pregnancy in Epidemic-prone Areas.
Status: COMPLETED
Conditions: Malaria, Falciparum
Interventions: DRUG: Intermittent preventive treatment:sulphadoxine-pyrimethamine|DEVICE: Insecticide-treated mosquito bed net
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combined tDCS and Cognitive Training to Reduce Impulsivity in Patients With Traumatic Brain Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Traumatic Brain Injury|Impulsivity
Interventions: DEVICE: Active Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Aripiprazole and D-Cycloserine to Treat Symptoms Associated With Autism
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: Aripiprazole|DRUG: Placebo|DRUG: D-cycloserine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupuncture on the Clinical Outcome of IVF-ET in Patients With Recurrent Implantation Failure
Status: UNKNOWN
Conditions: Acupuncture|Recurrent Implantation Failure
Interventions: PROCEDURE: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy, Safety, and Pharmacokinetics of XEMBIFY® Plus Standard Medical Treatment (SMT) Compared to Placebo Plus SMT to Prevent Infections in Participants With Hypogammaglobulinemia and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia
Status: RECRUITING
Conditions: Hypogammaglobulinemia|Bacterial Infections|B-cell Chronic Lymphocytic Leukemia
Interventions: DRUG: Xembify|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neonatal Erythropoietin in Asphyxiated Term Newborns
Status: COMPLETED
Conditions: Hypoxic-ischemic Encephalopathy
Interventions: DRUG: erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interim Buprenorphine: Leveraging Medication + Technology to Bridge Delays in Treatment Access
Status: COMPLETED
Conditions: Opioid-related Disorders
Interventions: DRUG: Interim Buprenorphine Treatment (IBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Use of BCG and Interferon Alpha in Bladder Cancer
Status: COMPLETED
Conditions: Carcinoma of Urinary Bladder, Superficial
Interventions: DRUG: Bacillus Calmette Guerin and interferon alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Amifostine & High-Dose Combination Chemotherapy in Treating Patients With Acute ML or CML
Status: WITHDRAWN
Conditions: Drug/Agent Toxicity by Tissue/Organ|Leukemia|Myelodysplastic Syndromes|Neutropenia
Interventions: DRUG: amifostine trihydrate|DRUG: cytarabine|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diagnostic Accuracy of ERCP-guided Versus Cholangioscopy-guided Tissue Acquisition in Patients With Indeterminate Biliary Strictures Suspected to be Intrinsic .
Status: UNKNOWN
Conditions: Cholangiocarcinoma|Biliary Stricture
Interventions: DEVICE: single operator cholangioscopy|DEVICE: ERCP guided brushing and biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Pharmacokinetics of E2609 and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared With Healthy Subjects
Status: COMPLETED
Conditions: Early Alzheimer's Disease
Interventions: DRUG: E2609
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-Paclitaxel and Bevacizumab in Treating Patients With Unresectable Stage IV Melanoma or Gynecological Cancers
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosarcoma|Cervical Adenosquamous Carcinoma|Cervical Carcinosarcoma|Cervical Squamous Cell Carcinoma|Clinical Stage IV Cutaneous Melanoma AJCC v8|Endometrial Adenosquamous Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Endometrioid Adenocarcinoma|Endometrial Mixed Cell Adenocarcinoma|Endometrial Mucinous Adenocarcinoma|Endometrial Serous Adenocarcinoma|Endometrial Undifferentiated Carcinoma|Fallopian Tube Adenocarcinoma|Fallopian Tube Carcinosarcoma|Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube Mucinous Adenocarcinoma|Fallopian Tube Serous Adenocarcinoma|Fallopian Tube Squamous Cell Carcinoma|Fallopian Tube Transitional Cell Carcinoma|Fallopian Tube Undifferentiated Carcinoma|Malignant Female Reproductive System Neoplasm|Malignant Ovarian Clear Cell Tumor|Malignant Ovarian Endometrioid Tumor|Malignant Ovarian Epithelial Tumor|Malignant Ovarian Mucinous Tumor|Malignant Peritoneal Neoplasm|Malignant Solid Neoplasm|Ovarian Carcinosarcoma|Ovarian Clear Cell Adenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian High Grade Serous Adenocarcinoma|Ovarian Mucinous Adenocarcinoma|Ovarian Serous Adenocarcinoma|Ovarian Transitional Cell Carcinoma|Ovarian Undifferentiated Carcinoma|Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Platinum-Sensitive Ovarian Carcinoma|Primary Peritoneal Carcinosarcoma|Primary Peritoneal Clear Cell Adenocarcinoma|Primary Peritoneal Serous Adenocarcinoma|Primary Peritoneal Transitional Cell Carcinoma|Primary Peritoneal Undifferentiated Carcinoma|Unresectable Melanoma|Uterine Corpus Carcinosarcoma
Interventions: BIOLOGICAL: Bevacizumab|OTHER: Laboratory Biomarker Analysis|DRUG: Nab-paclitaxel|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Interventions and Neurocognitive Outcomes
Status: NOT_YET_RECRUITING
Conditions: Sleep Disturbance|Amnestic Mild Cognitive Impairment
Interventions: DEVICE: Acoustic slow-wave activity enhancement|BEHAVIORAL: Cognitive behavioral therapy for insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Secondary Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Recurrent Mucinous Ovarian Cancer (HI-MOC Study)
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: OTHER: Cytoreductive surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Conservative Treatment and Graston and Cup Applications in Patients With Cervical Disc Herniation
Status: COMPLETED
Conditions: Neck Pain|Cervical Disc Herniation
Interventions: OTHER: conventional|OTHER: traditional and complementary medicine methods
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extending and Banding the Roux-en-Y Gastric Bypass
Status: ACTIVE_NOT_RECRUITING
Conditions: Morbid Obesity
Interventions: PROCEDURE: Standard RYGB|PROCEDURE: Extended Pouch RYGB|PROCEDURE: Banded extended pouch RYGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Stress Induced by Screening for Retinopathy of Prematurity - Should Speculum and Indentation Rather be Avoided
Status: COMPLETED
Conditions: Retinopathy of Prematurity
Interventions: OTHER: Speculum-free (SpF) fundoscopy|OTHER: Speculum (Sp) fundoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Safety and Efficacy of Genome-edited Hematopoietic Stem and Progenitor Cells in Sickle Cell Disease (SCD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease
Interventions: BIOLOGICAL: OTQ923|BIOLOGICAL: OTQ923
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients
Status: RECRUITING
Conditions: Perioperative Neurocognitive Dysfunction
Interventions: DIAGNOSTIC_TEST: Pittsburgh sleep quality index|DIAGNOSTIC_TEST: Self-rating depression scale|DIAGNOSTIC_TEST: Montreal Cognitive Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS
Status: RECRUITING
Conditions: Short Bowel Syndrome
Interventions: DRUG: glepaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effect of Low-Energy Extracorporeal Shockwave Therapy (ESWT) on the Renal Allograft in Transplant Recipients.
Status: UNKNOWN
Conditions: Transplant Dysfunction
Interventions: DEVICE: Extracorporeal Shockwave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: DRUG: dabigatran etexilate mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Eucalyptus Globulus and Mentha x Piperita on Muscle Soreness in Older Adults and the Elderly
Status: TERMINATED
Conditions: Muscle Soreness
Interventions: OTHER: Mentha x piperita|OTHER: Eucalyptus globulus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Insulin Versus Tablets for Latent Autoimmune Diabetes in Adults (LADA)
Status: UNKNOWN
Conditions: Latent Autoimmune Diabetes in Adults LADA
Interventions: DRUG: NovoMix 30|DRUG: Tablet treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Doxercalciferol Capsules in Participants With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Moderate to Severe Chronic Plaque Psoriasis
Interventions: DRUG: Doxercalciferol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction
Status: UNKNOWN
Conditions: Vitamin D Deficiency|Non-ST Elevation Myocardial Infarction (nSTEMI)|Inflammation|Coronary Artery Disease With Myocardial Infarction
Interventions: DRUG: Vitamin D3 50000 UNT Oral Capsule|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Immunotherapy With Allogeneic Dendritic Cells, DCP-001, in Patients With Acute Myeloid Leukaemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia in Remission
Interventions: BIOLOGICAL: DCP-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SafeHeal Anastomosis Feasibility Evaluation (SAFE)-2023 Study
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DEVICE: Colovac Colorectal Anastomosis Protection Device|PROCEDURE: Stoma creation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retro-active Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-identical Kidney Transplants
Status: RECRUITING
Conditions: End Stage Kidney Disease|Immunological Tolerance|Kidney Transplant Failure and Rejection|Chronic Kidney Diseases
Interventions: COMBINATION_PRODUCT: Conditioning and Stem cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Insulin Resistance Reducing Agents Pre and Post CABG on Post-operative Metabolic Status and Oxidative Stress
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Supplement pre CABG|DIETARY_SUPPLEMENT: Supplement post CABG|DIETARY_SUPPLEMENT: Supplement pre and post CABG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Exercise Counseling on Exercise Behavior in People With Type 2 Diabetes: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Exercise counseling|BEHAVIORAL: Supervised exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Highly Bioavailable Curcumin on Subjective Tinnitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Tinnitus, Subjective
Interventions: BIOLOGICAL: Curcumin-phosphatidylcholine|BIOLOGICAL: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Breaking Potentially Bad News in Lung Cancer Workup: Telephone Versus In-person Breaking of Final Diagnosis
Status: COMPLETED
Conditions: Lung Cancer|Diagnoses Disease|Psychosocial Stressor
Interventions: BEHAVIORAL: Telephone call|BEHAVIORAL: In-person meeting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain
Status: COMPLETED
Conditions: Pediatric Pain|Chronic Pain, Widespread|Musculoskeletal Pain
Interventions: BEHAVIORAL: Graded Exposure Therapy (GET Living)|BEHAVIORAL: Multidisciplinary Pain Management (MPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bedtime Insulins and Oral Antihyperglycemic Drugs in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hypoglycemia
Interventions: DRUG: NPL insulin|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Serum Adrenal Androgens Among Prepubertal and Pubertal Boys With Autism Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DIAGNOSTIC_TEST: serum total testosterone, serum androsterone, serum androstenedione and serum dehydroepiandrosterone sulfate|DIAGNOSTIC_TEST: The Childhood Autism Rating Scale (CARS)|DIAGNOSTIC_TEST: DSM-5 Diagnostic Criteria for ASD|DIAGNOSTIC_TEST: Assesment of IQ: The Stanford-Binet V (Stanford-Binet Intelligence Scales):
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers - Protocol 4
Status: COMPLETED
Conditions: Cardiovascular Disease|Heart Failure
Interventions: DRUG: Urocortin 2|DRUG: Urocortin 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Plyometric Exercises on Upper Extremity Function in Children With Unilateral Cerebral Palsy
Status: COMPLETED
Conditions: Sports Physical Therapy
Interventions: OTHER: Designed physical therapy|OTHER: Occupational therapy|OTHER: Conventional Therapy|OTHER: Plyometric training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: "Multimodal Prevention of Psychosis - Investigating Efficacy of N-Acetylcysteine and Psychotherapy in CHR-Patients"
Status: TERMINATED
Conditions: Prodromal Schizophrenia
Interventions: DRUG: N-Acetylcysteine|DRUG: Placebo|BEHAVIORAL: IPPI (Integrated Preventive Psychological Intervention)|BEHAVIORAL: PSM (Psychological stress management)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MRB 0.3% Serum Effectiveness on 2 Early Clinical Markers of Photoinduced Cutaneous Aging: Actinic Lentigo and Actinic Keratosis
Status: UNKNOWN
Conditions: Actinic Keratosis|Actinic Lentigo
Interventions: OTHER: Topical application of MRB 0.3% serum and placebo serum (hemi face or skull)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Integrative Therapy in Alcoholism
Status: COMPLETED
Conditions: Alcoholism
Interventions: DRUG: Acamprosate|BEHAVIORAL: Integrative behavior therapy|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Duration of Spinal Manipulation Effects as Influenced by Orthotics
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: foot orthotics|DEVICE: Sham foot orthotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Correlates of Hypoxia in Metastatic Melanoma
Status: WITHDRAWN
Conditions: Melanoma|Skin Cancer
Interventions: DRUG: Pimonidazole hydrochloride (Hypoxyprobe™-1)|DRUG: Optional 18F-FMISO PET scan (18F-fluoromisonidazole)|PROCEDURE: Surgical Resection of Melanoma Metastases
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety of the Addition of Canagliflozin in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin and Sitagliptin
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Canagliflozin, 100 mg|DRUG: Canagliflozin, 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Versus Perineural Effect Dexamethasone in Interscalene Nerve Block With Levobupivacaine
Status: UNKNOWN
Conditions: Shoulder Pain
Interventions: DRUG: Perineural levobupivacaine|DRUG: Perineural dexamethasone in addition to levobupivacaine|DRUG: Intravenous dexamethasone with perineural levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Assessing the Impact of Pioglitazone on Skin Barrier Function in Atopic Dermatitis Patients
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: DRUG: Pioglitazone|DRUG: Placebo (for pioglitazone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Nausea and Vomiting: Ramosetron Plus Aprepitant vs Palonosetron Plus Aprepitant
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: aprepitant|DRUG: palonosetron|DRUG: Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alemtuzumab for ANCA Associated Refractory Vasculitis
Status: UNKNOWN
Conditions: Vasculitis|Microscopic Polyangiitis|Granulomatosis With Polyangiitis|Wegener's
Interventions: DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Other Inflammatory Arthritis|Post-Traumatic Arthritis|Juvenile Rheumatoid Arthritis|Avascular Necrosis
Interventions: DEVICE: Total Knee Arthroplasty|DEVICE: Total knee replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Potential Immune Interference When GlaxoSmithKline (GSK) Biologicals' MenABCWY Vaccine is Administered to Healthy Subjects Aged 10-25 Years
Status: COMPLETED
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: MenABCWY vaccine|BIOLOGICAL: rMenB+OMV NZ (Bexsero) vaccine|BIOLOGICAL: MenACWY (Menveo) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Allopurinol in Functional Impairment (ALFIE) Trial: 'Improving Muscle Strength'
Status: COMPLETED
Conditions: Sarcopenia
Interventions: DRUG: Allopurinol|DRUG: Lactose tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Health Communication During the Transition From Pediatric to Adult Diabetes Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Plan, Reflect, and Engage with Providers for Diabetes Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT