pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Recombinant Human Anti-PD-1 Monoclonal Antibody in Patients With Advanced Tumours
Status: UNKNOWN
Conditions: Advanced Solid Tumours|Cervical Cancer|Malignant Mesothelioma|Lymphoma|Non-Small-Cell Lung Cancer
Interventions: DRUG: SG001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olanzapine for Chemotherapy-induced Nausea and Vomiting Prophylaxis
Status: COMPLETED
Conditions: Complete Response Rate to Chemotherapy-induced Nausea and Vomiting Prophylaxis
Interventions: DRUG: Olanzapine 10 Mg ORAL TABLET|DRUG: Olanzapine 5 Mg ORAL TABLET|DRUG: Placebo ORAL TABLET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Immunogenicity, Safety and Tolerability of the Convacell Vaccine.
Status: COMPLETED
Conditions: COVID-19|Immunologic Factors|Coronavirus Infections|Respiratory Tract Infections
Interventions: BIOLOGICAL: Subunit recombinant vaccine for the prevention of coronavirus infection|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Maternal Postioning on Spread of Local Anesthetic After Epidural Analgesia
Status: COMPLETED
Conditions: Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Interventions: PROCEDURE: lateral position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Recombinant LH Supplementation in Patients With Suboptimal Response to Recombinant FSH Undergoing ICSI
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: fix dose r-FSH (Gonal-f)|DRUG: r-LH supplementation|DRUG: r-FSH (Gonal-f)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MIST Versus M-MIST for the Treatment of Intrabony Defects
Status: RECRUITING
Conditions: Periodontitis|Intrabony Periodontal Defect|Periodontitis, Chronic
Interventions: PROCEDURE: M-MIST|PROCEDURE: MIST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Performance During Hyperglycemia , and Brain Tissue Integrity in Youth With Type 1 Diabetes and in Healthy
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: MRI including DTI , EEG, CGMS|BEHAVIORAL: Neurocognitive tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections
Status: UNKNOWN
Conditions: Spinal Stenosis
Interventions: DEVICE: Therm-AppTM TH, thermographic camera|DRUG: epidural injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial to Assess the Efficacy and Safety of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol for the Treatment of Seasonal Allergic Rhinitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: 80 mcg Ciclesonide|DRUG: 160 mcg Ciclesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antiplatelet and Anti-inflammatory Effects of Statins and Ezetimibe
Status: COMPLETED
Conditions: Stable Angina
Interventions: DRUG: Simvastatin 80 mg/day for 6 weeks|DRUG: Ezetimibe 10 mg / Simvastatin 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of On-demand Meteospasmyl® Use in Irritable Bowel Syndrome (IBS)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: anti spasmodic agents|DRUG: alverine citrate, simeticone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Oral Mirabegron on the Heart in Healthy Males and Females
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Placebo|DRUG: mirabegron|DRUG: moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Effectiveness of XCell on Autolytic Debridement of Venous Ulcers
Status: COMPLETED
Conditions: Venous Ulcer
Interventions: DEVICE: XCell cellulose wound dressing|DEVICE: Impregnated gauze dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Prexasertib (LY2606368), CHK1 Inhibitor, and LY3300054, PD-L1 Inhibitor, in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: LY3300054|DRUG: Prexasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Temperature Controlled Laminar Airflow (TLA)-Treatment in Perennial Allergic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Temperature controlled Laminar Airflow (TLA)|DEVICE: Placebo TLA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Belantamab mafodotin|DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Trial of Dymista Nasal Spray in Children Ages 4 to 11 With Seasonal Allergic Rhinitis (SAR)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: azelastine hydrochloride and fluticasone propionate|DRUG: Dymista vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Blepharitis With Povidone-Iodine 1%
Status: UNKNOWN
Conditions: Anterior Blepharitis
Interventions: DRUG: Povidone-Iodine 1 % Topical Solution|DRUG: Eyelid cleansing wipes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ONO-8577 in Patients With Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: ONO-8577|DRUG: solifenacin succinate + mirabegron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Knee OA
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: sc-rAAV2.5IL-1Ra
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ophthalmologic Safety of Long Term Treatment With Pramipexole Compared to Bromocriptine or Other Dopamine Agonists in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Pramipexole|DRUG: Bromocriptine and other dopamine agonists
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Surgical Treatment by Radiofrequency Ablation on Valvular Patients: Efficacy at 3 Months
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SJP-0035 Ophthalmic Solution in Patients With Moderate to Severe Corneal Epithelial Disorders
Status: COMPLETED
Conditions: Corneal Epithelial Disorders
Interventions: DRUG: High Dose SJP-0035 Ophthalmic Solution|DRUG: Low Dose SJP-0035 Ophthalmic Solution|DRUG: Vehicle of SJP-0035 Ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationships Among FVIII, t-PA/PAI-1, and MMP-9 Levels and Intracranial Hemorrhage Complications After Thrombolysis With Alteplase in Patients With Acute Ischemic Stroke: Protocol for a Multicenter Retrospective Study
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: Ateptidase
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: recombinant tissue plasminogen activator|DRUG: captopril
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Blood Parameters of the Malnourished Children: Before and After Giving Nutritional Biscuit's Treatment
Status: COMPLETED
Conditions: Undernutrition
Interventions: DIETARY_SUPPLEMENT: Nutritional biscuits and khichadi|DIETARY_SUPPLEMENT: Khichadi
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-therapeutic Identification of Dihydropyrimidine Dehydrogenase Gene (DPD) Deficiency for Predicting Toxicity to Fluoropyrimidines
Status: TERMINATED
Conditions: Colorectal Cancer|Intravenous 5 Fluorouracile
Interventions: GENETIC: Blood sample for phenotypic and pharmacogenetic analysis.|GENETIC: Blood sample for phenotypic and pharmacogenetic analysis.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Double Blinded Study to Examine the Effect of Alpha Agonist Ointment on Fecal Incontinence in Patients With Idiopathic Fecal Incontinence
Status: WITHDRAWN
Conditions: Idiopathic Fecal Incontinence
Interventions: DRUG: alpha agonist ointment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Ulipristal Acetate in Females With Anemia Associated With Uterine Leiomyoma
Status: WITHDRAWN
Conditions: Leiomyomas
Interventions: DRUG: Ulipristal Acetate|DRUG: Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between Lap. Dual Approach, Lap. Trans Abdominal Pre-peritoneal and Lichtenstein Procedures
Status: COMPLETED
Conditions: Inguinal Hernioplasty
Interventions: PROCEDURE: dual approach laparoscopic inguinal hernioplasty|PROCEDURE: TAPP|PROCEDURE: (lichtenstein) repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 12 Weeks Vitamin D Supplementation and Physical Activity in PD Patients With DBS
Status: COMPLETED
Conditions: Vitamin D Deficiency|Parkinson Disease
Interventions: DRUG: Juvit D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pharmacokinetic Interaction Study Between TMC435, Atorvastatin and Simvastatin in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: TMC435|DRUG: Atorvastatin|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Lorcaserin Versus Duloxetine for the Treatment of Chemotherapy-Induced Peripheral Neuropathy
Status: UNKNOWN
Conditions: Chemotherapy-Induced Peripheral Neuropathy
Interventions: DRUG: Duloxetine 60 mg qd|DRUG: Lorcaserin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors That Have Not Responded to Chemotherapy
Status: COMPLETED
Conditions: Adult Solid Neoplasm
Interventions: DRUG: Hydroxychloroquine|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects
Status: UNKNOWN
Conditions: Presbyopia|Pseudophakia
Interventions: DEVICE: Raindrop Near Vision Inlay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Axillary Versus Jugular Central Venous Catheterization
Status: COMPLETED
Conditions: Critical Illness
Interventions: PROCEDURE: Real-time ultrasound-guided central vein catheterization.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers
Status: COMPLETED
Conditions: CO2 Clearance|Mask Comfort|Rebreathing Exhaled Gas
Interventions: DEVICE: Evaluated 4 masks used for NIV with mechanical ventilators
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Abemaciclib Capsules (Reference Formulation)|DRUG: Abemaciclib Tablet (Test Formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Celecoxib Plus Nucleos(t)Ide Analogues on the Hepatitis B Surface Antigen of Virally Suppressed Subjects With Chronic Hepatitis B
Status: UNKNOWN
Conditions: To Evaluate the Safety and Efficacy of Celecoxib Plus Nucleos(t)Ide Analogues in Nucleos(t)Ide-treated Patients With Chronic Hepatitis B
Interventions: DRUG: Celecoxib|DRUG: nucleos(t)ide analogue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Chemotherapy by BCNU-TMZ Combination in Newly Diagnosed Anaplastic Oligodendrocytic Tumors: Phase II Trial With Translational Molecular Analysis
Status: COMPLETED
Conditions: Oligodendroglioma; Oligoastrocytoma
Interventions: DRUG: Bis-Chloroethyl-Nitroso-Urea (BCNU) withTemozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Manual Therapy in the Quality of Life in Tension-Type Headache
Status: COMPLETED
Conditions: Quality of Life
Interventions: OTHER: Suboccipital inhibitory|OTHER: Spinal manipulative|OTHER: Combined treatment|OTHER: Control group.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension and Safety Study for Participants With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144
Status: TERMINATED
Conditions: Crohn Disease
Interventions: DRUG: Etrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medacta GMK Sphere® vs. Medacta GMK PS Post-Market Outcomes Study
Status: UNKNOWN
Conditions: Osteoarthritis|Osteoarthritis, Knee|Joint Disease
Interventions: DEVICE: Medacta GMK Sphere® Medial-Pivot Knee Prosthesis|DEVICE: Medacta GMK PS Posterior Stabilized Knee Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of Oxygen Status on Hypoxia Inducible Factor 1-α and Inflammation. A Pilot Proof of Principle Study.
Status: COMPLETED
Conditions: Hypoxia|Hyperoxia
Interventions: OTHER: Hypoxia|OTHER: Hyperoxia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Botulinum Toxin and Mesotherapy on Enhancement of Facial Scarring
Status: COMPLETED
Conditions: Facial Scars
Interventions: OTHER: Botulinum Toxin Type A|OTHER: Mesotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Chart Review to Evaluate Safety and Tolerability of ADVATE Among Previously Untreated Patients in China With Moderate to Severe Hemophilia A
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: Octocog alfa (recombinant human coagulation factor VIII)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase III Study to Demonstrate the Safety and Efficacy of DWP-450 to Treat Glabellar Lines - EV001
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: BIOLOGICAL: Botulinum toxin, Type A|OTHER: 0.9% sterile, unpreserved saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Rivaroxaban to Reduce the Risk of Major Venous and Arterial Thrombotic Events, Hospitalization and Death in Medically Ill Outpatients With Acute, Symptomatic Coronavirus Disease 2019 (COVID-19) Infection
Status: TERMINATED
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: DRUG: Rivaroxaban|OTHER: Placebo|OTHER: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Fatigue and Exercise Capacity in Patients With Type 2 Diabetes Mellitus and HFpEF
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Heart Failure Preserved Ejection Fraction
Interventions: OTHER: Evaluation of central and peripheral neuromuscular fatigue
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Open Label Study to Compare the Current Phase II and Planned Phase III Capsule Formulation of AZD6244
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD6244 Dosing Period 1|DRUG: AZD6244 Dosing Period 2|DRUG: AZD6244 Dosing Period 3|DRUG: AZD6244 Dosing Period 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Children's Bipolar Network Treatment Trial I
Status: RECRUITING
Conditions: Bipolar Disorder|Bipolar I Disorder|Bipolar II Disorder|Other Specified Bipolar and Related Disorder|Mood Instability|Child Mental Disorder|Adolescent - Emotional Problem
Interventions: OTHER: Medication or psychosocial treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cabozantinib In Combo With NIVO + IPI In Advanced NCCRCC
Status: RECRUITING
Conditions: Papillary Renal Cell Carcinoma|Unclassified Renal Cell Carcinoma|Translocation Renal Cell Carcinoma|Chromophobe Renal Cell Carcinoma|Collecting Duct Renal Cell Carcinoma|Renal Cell Carcinoma|Unresectable Advanced Renal Cell Carcinoma|Metastatic Ncc Renal Cell Carcinoma
Interventions: DRUG: Cabozantinib|DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Chicken Extract on Mental Energy in Healthy Adults and the Underlying Mechanisms
Status: NOT_YET_RECRUITING
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Chicken extract supplement (high-dose)|DIETARY_SUPPLEMENT: Chicken extract supplement (low-dose)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Physical Activity Seated Exercise - Phase 2
Status: RECRUITING
Conditions: Stroke|Chronic Stroke|Stroke, Ischemic|Stroke Hemorrhagic
Interventions: OTHER: Virtual Physical Activity Seated Exercises (V-PASE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Forces to Improve Statin Adherence (Study B)
Status: COMPLETED
Conditions: Medication Adherence|High Blood Pressure|Diabetes
Interventions: BEHAVIORAL: Comparison to peers|BEHAVIORAL: Adherence feedback|DEVICE: Electronic pill bottle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Health Literacy on COVID-19 for All: Co-creation and Evaluation of Interventions for Ethnic Minorities and Chinese People With Chronic Illnesses in Hong Kong
Status: NOT_YET_RECRUITING
Conditions: Digital Health Literacy|COVID-19
Interventions: BEHAVIORAL: Digital health literacy intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Effects of Multiple Doses of Cebranopadol on the Electrical Activity of the Heart in Healthy Subjects
Status: COMPLETED
Conditions: Prolonged QTc Interval|Pharmacokinetic
Interventions: DRUG: 100 μg cebranopadol|DRUG: 200 μg cebranopadol|DRUG: 400 μg cebranopadol|DRUG: Placebo to cebranopadol encapsulated tablets|DRUG: 400 mg Moxifloxacin|DRUG: Placebo to moxifloxacin encapsulated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Weekly Paclitaxel With Neratinib and Trastuzumab in Women With Metastatic HER2-positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|BIOLOGICAL: trastuzumab|DRUG: Neratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Optimized 5-FU Dosing and Standard Dosing in Metastatic Colorectal Cancer Patients Treated With mFOLFOX6
Status: TERMINATED
Conditions: Colorectal Cancer, Metastatic
Interventions: OTHER: Pharmacokinetic 5-FU dose adjustment using OnDose® assay|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Interactions Between Atorvastatin and Metformin in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Period I : atorvastatin, Period II : atorvastatin and metformin|DRUG: Period I : metformin, Period II : atorvastatin and metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer
Status: RECRUITING
Conditions: Differentiated Thyroid Cancer|Pediatric Cancer|Cancer|Cancer, Thyroid
Interventions: DRUG: Larotrectinib monotherapy|RADIATION: 131I therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Active and Passive DNA Hypomethylation
Status: RECRUITING
Conditions: Myelodysplastic Syndromes|Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia
Interventions: DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Myeloid Leukemia With Arsenic and All-trans Retinoid Acid
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: All-trans retinoic acid|DRUG: Arsenic Trioxide|DRUG: Realgar-Indigo naturalis formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of TQB3616 Capsules Combined With Fulvestrant Injection in Subjects With Advanced Breast Cancer
Status: UNKNOWN
Conditions: HR-positive, HER2-negative Advanced Breast Cancer
Interventions: DRUG: TQB3616 capsules|DRUG: Fulvestrant injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Performance and Durability of the TIES® Implant in Patients Requiring a Permanent Ileostomy
Status: TERMINATED
Conditions: Ileostomy - Stoma
Interventions: DEVICE: TIES® (Transcutaneous Implant Evacuation System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Unnecessary Gastric Decompression in Distal Elective Bowel Anastomoses in Children. A Randomized Study
Status: COMPLETED
Conditions: Unnecessary Nasogastric Tube|Bowel Anastomosis
Interventions: OTHER: Non application of nasogastric tube in the experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of TransAeris® System in Surgical Patients at Risk of Prolonged Mechanical Ventilation
Status: COMPLETED
Conditions: Ventilator-Induced Diaphragm Dysfunction
Interventions: DEVICE: TransAeris System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer|Esophageal Adenocarcinoma|Esophageal Squamous Cell Cancer|Siewert Type 1 GEJ Cancer|Pancreatic Cancer
Interventions: DRUG: Futibatinib|DRUG: Pembrolizumab|DRUG: Cisplatin|DRUG: 5-FU|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: Levoleucovorin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effectiveness of Epoetin Alfa in Facilitating Self-donation of Blood Before Surgery in Non-anemic Patients Who Are Undergoing Orthopedic, Heart and Blood Vessel, or Breast Reduction Surgery; Performed in Combination With a Procedure to Reduce Blood Loss During Surgery.
Status: COMPLETED
Conditions: Blood Transfusion|Blood Transfusion, Autologous|Orthopedic Procedures|Orthopedic Surgery|Cardiovascular Surgical Procedures|Mammaplasty
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention Trial in High Metabolic Risk Chinese
Status: COMPLETED
Conditions: Metabolic Syndrome|Obesity
Interventions: BEHAVIORAL: Programmed smartphone intervention|BEHAVIORAL: Programmed smartphone plus dietitian intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids
Status: COMPLETED
Conditions: Normal Physiology
Interventions: DRUG: Methylprednisolone sodium succinate(Solu-Medrol)|DRUG: Topical methylprednisolone (Advantan emulsion 0 /1%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The HERO-study: Effects of Roflumilast in Patients With COPD (Chronic Obstructive Pulmonary Disease) (BY217/M2-121)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease, COPD
Interventions: DRUG: Roflumilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intravenous or Hepatic Arterial Infusion of Fotemustine in Treating Patients With Unresectable Liver Metastases From Eye Melanoma
Status: TERMINATED
Conditions: Intraocular Melanoma|Metastatic Cancer
Interventions: DRUG: fotemustine|DRUG: isolated perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ID Administration of fIPV Using Intradermal Adapters vs. BCG Syringe
Status: COMPLETED
Conditions: IPV
Interventions: DEVICE: Westpharma ID adapter|DEVICE: Star ID syringe|DEVICE: BCG NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Breast Reconstruction Following Breast Cancer in Very High Risk Patients
Status: WITHDRAWN
Conditions: Breast Cancer|Malignant Neoplasm of Breast
Interventions: PROCEDURE: Immediate Breast Reconstruction|PROCEDURE: Delayed Breast Reconstruction|OTHER: Breast-Q questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypofractionated Proton Beam Radiotherapy for Inoperable Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: RADIATION: Proton Beam Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy and Safety in Japanese Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes|High Blood Sugar
Interventions: DRUG: Dapagliflozin|DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of 100% Orange Juice on Skin Health in Women
Status: RECRUITING
Conditions: Skin Health
Interventions: OTHER: Orange juice|OTHER: Placebo juice (Fanta)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Clinical Effects of Rituximab and Glatiramer Acetate in Secondary Progressive Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Secondary Progressive Multiple Sclerosis
Interventions: DRUG: Rituximab|DRUG: Glatiramer Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Psilocybin
Status: NOT_YET_RECRUITING
Conditions: Safety, Feasibility, and Tolerability of Psilocybin Treatment in Individuals With Functional Impairment Due to Psychiatric Symptoms
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamponade vs Partial Myometrial Resection of Lower Uterine Segment in Management of Placenta Accreta Spectrum Cases
Status: NOT_YET_RECRUITING
Conditions: Placenta Accreta
Interventions: PROCEDURE: Tamponade of lower uterine segment in management of placenta accreta spectrum cases|PROCEDURE: partial myometrial resection of lower uterine segment in management of placenta accreta spectrum cases
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Macitentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of the Covid-19 Pandemic on Orthopedic Trauma Management
Status: COMPLETED
Conditions: Trauma|COVID-19 Pandemic
Interventions: OTHER: epidemyolojical
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury
Status: COMPLETED
Conditions: Covid19|ARDS, Human|Lung Injury, Acute|Ventilation Perfusion Mismatch
Interventions: DRUG: Nebulised heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Activity Counseling During Pulmonary Rehabilitation
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: physical activity counseling program|BEHAVIORAL: sham counseling program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Brahma Kumaris Raja Yoga Meditation on Quality of Life of Youth in the Deaddiction Center of Biratnagar
Status: NOT_YET_RECRUITING
Conditions: Prevalence|Depression|Happiness|Quality of Life|Anxiety
Interventions: BEHAVIORAL: Rajyoga Meditation Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Ontamalimab as Induction Therapy in Participants With Moderate to Severe Crohn's Disease (CARMEN CD 306)
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: Ontamalimab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Minocycline (NPL-2003) in Adults With Obsessive-Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder
Interventions: DRUG: NPL-2003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study
Status: COMPLETED
Conditions: Periumbilical Subcutaneous Adipose Tissue Reduction
Interventions: DRUG: Drug: salmeterol xinafoate|DRUG: Drug: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Relationship of Multifidus and Gastrocnemius Muscle Thickness With Postural Stability in Patients With Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke|Postural; Defect|Hemiplegia
Interventions: OTHER: Measurement of multifidus and gastrocnemius muscle thickness with Ultrasound|OTHER: Berg Balance Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaccine Therapy Plus Sargramostim in Treating Patients With Stage III or Stage IV Cancer
Status: COMPLETED
Conditions: Breast Cancer|Lung Cancer|Ovarian Cancer
Interventions: BIOLOGICAL: HER-2/neu peptide vaccine|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Spinal Manipulation on Hip Extension Strength and Jump Height
Status: NOT_YET_RECRUITING
Conditions: Weakness, Muscle
Interventions: PROCEDURE: Lumbar manipulation|PROCEDURE: Sham Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cytokine Adsorption During Complex Cardiac Surgery: a Controlled Randomized Trial
Status: NOT_YET_RECRUITING
Conditions: Post-cardiac Surgery|Inflammation|Organ Dysfunction Syndrome|Cardiac Disease|Cardio-Pulmonary Bypass
Interventions: DEVICE: Hemoadsoprtion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Self-Compassion Intervention on Shame and Mental Health Treatment-Seeking
Status: COMPLETED
Conditions: Psychological Distress
Interventions: OTHER: Self-compassion workshop|OTHER: Mental health literacy workshop|OTHER: Control workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Integrated CAM Treatment in Hospitalized Patients
Status: RECRUITING
Conditions: Low Back Pain|Neck Pain|Knee Pain|Shoulder Pain|Intervertebral Disc Herniation|Spinal Stenosis
Interventions: DRUG: Herbal medicine|PROCEDURE: Acupuncture|PROCEDURE: Pharmacopuncture|PROCEDURE: Bee venom pharmacopuncture|PROCEDURE: Chuna manipulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Trial of Venetoclax and Rituximab as Initial Therapy in Older Patients With Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Venetoclax Oral Tablet [Venclexta]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: China 3T MRI Study
Status: RECRUITING
Conditions: Bradycardia|Tachycardia|Heart Failure
Interventions: DEVICE: China market released 3.0T Magnetic resonance (MR) conditional CIED systems
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase II Study of Stereotactic Ablative Body Radiotherapy for Metastases to the Lung (TROG 13.01 SAFRON II)
Status: COMPLETED
Conditions: Cancer|Metastases to the Lung
Interventions: RADIATION: Multi-fraction SABR|RADIATION: Single Fraction SABR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Adding AMG 479 to First Line Chemotherapy in Patients With Optimally Debulked Epithelial Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Neoplasms
Interventions: DRUG: AMG 479|DRUG: AMG 479 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Using Yupingfeng Powder With Variation for the Treatment of Allergic Rhinitis
Status: UNKNOWN
Conditions: Allergic Rhinitis
Interventions: DRUG: Yupingfeng Powder granules|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Human Albumin on Coagulation Competence and Hemorrhage
Status: UNKNOWN
Conditions: Hemorrhage; Complicating Delivery, Coagulation Defect
Interventions: DRUG: 5% Human Albumin " Behring"|DRUG: Lactated Ringer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness-Based Interventions for OCD
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Muse|BEHAVIORAL: Cognitive Behaviour Therapy (CBT)|BEHAVIORAL: Mindfulness-Based Cognitive Therapy (MBCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Split-mouth, Comparative Study to Compare Clinical Outcomes of Two Different Posterior Composite
Status: UNKNOWN
Conditions: Caries|Defective Tooth Restorations
Interventions: DEVICE: Direct restorative treatment with fast-curing composites (Tetric PowerFill/ Tetric PowerFlow)|DEVICE: Direct restorative treatment with conventionally applied composites (Tetric EvoCeram Bulk Fill/ Tetric EvoFlow Bulk Fill)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A RCT COMPARING LACTULOSE AND RIFAXIMIN ASSOCIATED WITH A VEGETABLE DIET IN THE PREVENTION OF POST-TIPS OVERT HEPATIC ENCEPHALOPATHY
Status: UNKNOWN
Conditions: Cirrhotic Patients Undergoing TIPS Placement
Interventions: DRUG: lattulose and rifaximine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CEQUA for Sjogren's Syndrome Dry Eye
Status: COMPLETED
Conditions: Dry Eye|Dry Eye Syndromes|Sjogren's Syndrome
Interventions: DRUG: Cyclosporine 0.09% Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Intensive Care Unit Acquired Weakness
Interventions: OTHER: Conventional Physiotherapy|OTHER: Conventional Physiotherapy+ inspiratory muscle training|OTHER: inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Mitogenic-Activated Protein Kinase (MAPK) Inhibition in Rosacea
Status: COMPLETED
Conditions: Rosacea, Erythematotelangiectatic
Interventions: DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Ultrasound Guided Transbronchial Aspiration (EBUS-TBNA) in Non Small Cell Lung Cancer (NSCLC) in a Tuberculosis-endemic Country
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: PROCEDURE: EBUS-TBNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: LIFT Intervention in Liver Transplant Candidates
Status: RECRUITING
Conditions: Frailty|Cirrhosis|Liver Transplant
Interventions: BEHAVIORAL: "LIver FrailTy" intervention (LIFT)|BEHAVIORAL: "Realistic Effort Action Planning" intervention (REAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of CPPLAI in Laparoscopic Sleeve Gastrectomy Patients
Status: COMPLETED
Conditions: Obesity, Morbid|Pain, Postoperative
Interventions: PROCEDURE: CPPLAI|OTHER: Placebo|DRUG: Bupivacaine 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Superficial Cervical Nerve Block vs NSAIDs for the Relief of Shoulder Pain After Laparoscopic Surgeries
Status: COMPLETED
Conditions: Relieve Shoulder Pain After Laparoscopic Surgeries
Interventions: OTHER: Superficial cervical nerve block|OTHER: NSAID|OTHER: General anesthesia|OTHER: IV placebo|OTHER: Placebo superficial cervical nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-country Project on the Role of Diet, Food-related Behavior, and Obesity in the Prevention of Depression
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Multi-nutrient supplement|BEHAVIORAL: Behavioral Activation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pressurized Cold Application for Patients Total Knee Prosthesis Surgery
Status: COMPLETED
Conditions: Knee Prosthesis|Cryotherapy|Pain|Patient Satisfaction
Interventions: DEVICE: compressed cold therapy bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (LEAP-010) (MK-7902-010)-China Extension Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KPI-121 1% Versus Prednisolone for the Treatment of Inflammation Following Cataract Surgery in Children
Status: TERMINATED
Conditions: Ocular Inflammation
Interventions: DRUG: KPI-121 1%|DRUG: Prednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of PledOx + FOLFOX6 Compared to Placebo + FOLFOX6 in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Advanced Metastatic (Stage IV) Colorectal Cancer
Interventions: DRUG: PledOx (2 µmol/kg)|DRUG: PledOx (5 µmol/kg)|DRUG: PledOx (10 µmol/kg)|DRUG: Placebo (0,9% NaCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT