pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Varenicline on Reward Responses and Cognition in Adolescent Smokers
Status: COMPLETED
Conditions: Tobacco Use Disorders
Interventions: DRUG: Varenicline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Flavonols Cocoa Intake for the Improvement of Body Fat Composition in Athletes
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Cocoa group|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tunneled Peripherally Inserted Central Catheter (PICC) in Adult Patients and Associated Outcomes
Status: RECRUITING
Conditions: CLABSI - Central Line Associated Bloodstream Infection|Deep Vein Thrombosis|Dislodged Catheter|Occlusion|Catheter Rupture|Catheter (Other); Complications
Interventions: PROCEDURE: Subcutaneous tunnelling|PROCEDURE: Non-tunnelling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Investigation of the Steady State Pharmacokinetics of Sirolimus, Mycophenolat Mofetil and Fluvastatin After Renal Transplantation
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: sirolimus, mycophenolat mofetil, fluvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Underwater Ultrasound Therapy on Hand Function and Quality of Life in Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: underwater ultrasound|DEVICE: sham underwater ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation for Depressed Smokers
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoking|Depression
Interventions: BEHAVIORAL: Smoking Cessation Treatment|DRUG: Nicotine Replacement Therapy|BEHAVIORAL: CBASP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole-body Vibration With or Without Localized Radiofrequency and Body Composition in Obese Female
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: vibrating platform (Bioplate RF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact Dexmedetomidine on Postoperative Delirium in Patients After Intracranial Operation for Brain Tumor
Status: COMPLETED
Conditions: Central Nervous System Diseases
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Mivavotinib (CB-659) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Status: TERMINATED
Conditions: Non-GCB/ABC Diffuse Large B-Cell Lymphoma|With and Without MyD88 and/or CD79B Mutations
Interventions: DRUG: Mivavotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin For Intracerebral Hemorrhage Study
Status: TERMINATED
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: Simvastatin 80 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.028: Study of haNK™ for Infusion in Subjects With Metastatic or Locally Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor
Interventions: BIOLOGICAL: haNK™ for Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Window of Opportunity Study of VS-6063 (Defactinib) in Surgical Resectable Malignant Pleural Mesothelioma Participants
Status: TERMINATED
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: VS-6063
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial Evaluate the Immunogenicity and Safety Profile of HPV Vaccine
Status: COMPLETED
Conditions: Human Papilloma Virus Infection
Interventions: BIOLOGICAL: Recombinant Nonavalent (Types 6/11/16/18/31/33/45/52/58) Human Papillomavirus (HPV) Vaccine (Escherichia Coli)|BIOLOGICAL: Recombinant Quadrivalent Human Papillomavirus (Types 6,11,16,18) Vaccine (Saccharomyces cerevisiae)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bioglass Wound Dressing in Treatment of Chronic Wound in Different Stage：a Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Chronic Wound
Interventions: DEVICE: Bioactive glass wound dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Salivary Gland Neoplasms
Interventions: DRUG: Apalutamide|DRUG: GnRH Agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gender-Specific Combination HIV Prevention for Youth in High Burden Settings (MP3-Youth)
Status: COMPLETED
Conditions: HIV|Adolescent Behavior|Gender
Interventions: OTHER: Male-Specific Intervention Package|OTHER: Female-Specific Intervention Package|DRUG: Pre-Exposure Prophylaxis (Females)|BEHAVIORAL: Cash Transfer Cohort (Females)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: GAMBIT Trial: Cisplatin Plus Irinotecan in the Treatment of Gallbladder or Biliary Tract Cancer
Status: UNKNOWN
Conditions: Biliary Cancer
Interventions: DRUG: Irinotecan|DRUG: Cisplatin|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: Nivolumab|DRUG: Cisplatin|DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: Pemetrexed|DRUG: Carboplatin|DRUG: Paclitaxel|BIOLOGICAL: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc)
Status: RECRUITING
Conditions: Sarcoma|Radiosurgery
Interventions: DRUG: Atezolizumab|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
Status: COMPLETED
Conditions: Aggressive Periodontitis
Interventions: PROCEDURE: Full-mouth ultrasonic debridement|DRUG: Clarithromycin|DRUG: Amoxicillin|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utilizing Advocates and Supporters to Increase Lung Cancer Screening Rates in Eligible Participants
Status: RECRUITING
Conditions: Breast Carcinoma|Lung Carcinoma
Interventions: BEHAVIORAL: Health Education|OTHER: Health Promotion and Education|BEHAVIORAL: Patient Navigation|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: OTHER: Standard mechanical debridement|DEVICE: Er:YAG laser-assisted debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NIPPV vs.nCPAP During LISA Procedure
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: PROCEDURE: Nasal Intermittent Positive Pressure Ventilation (NIPPV)|PROCEDURE: Nasal continuous positive airway pressure (NCPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, and Efficacy Profile of Rivoceranib With Paclitaxel in Advanced Gastric or Gastroesophageal Junction Cancer
Status: TERMINATED
Conditions: Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Rivoceranib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pivotal Trial of a Novel Paclitaxel-Coated Percutaneous Angioplasty Balloon
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Cardiovascular Ingenuity (CVI) Paclitaxel-coated Percutaneous Transluminal Angioplasty Balloon Catheter|DEVICE: EverCross Percutaneous Transluminal Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupressure on Xerostomia in Head and Neck Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer|Xerostomia
Interventions: BEHAVIORAL: Self-administered acupressure|OTHER: Oral health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab And Combination Chemotherapy in Rectal Cancer Until Surgery
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Irinotecan|DRUG: Oxaliplatin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and/or Janus Kinase (JAK) Inhibitors
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: BIOLOGICAL: GSK3196165 (Otilimab)|BIOLOGICAL: Sarilumab|DRUG: Placebo to GSK3196165/ Sarilumab|DRUG: csDMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer|Medullary Thyroid Cancer|Colon Cancer|Any Solid Tumor
Interventions: DRUG: LOXO-292
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Salicylate on Glucose Metabolism in Insulin Resistance States
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Salsalate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Chidamide Combined With Azacitidine and Mitoxantrone Liposome in the Treatment of Relapsed/Refractory (nTFHL)
Status: NOT_YET_RECRUITING
Conditions: T Cell Lymphoma
Interventions: DRUG: Cidapenem combined with azacitidine and mitoxantrone liposome (CAM) regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Seizure Therapy Versus Electroconvulsive Therapy for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DEVICE: Magpro X100|DEVICE: ThymatronSystem Ⅳ Electroconvulsive System|OTHER: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Hand-acupuncture and Electro-acupuncture Stimulation in the Treatment of Menopause
Status: COMPLETED
Conditions: Menopause|Puncture Site Reaction
Interventions: BEHAVIORAL: Hand-acupuncture|DEVICE: Electrico-acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Local Methotrexate Injections for the Treatment of Nail Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Nail Psoriasis
Interventions: DRUG: Methotrexate|DRUG: Triamcinolone Acetonide 10mg/mL|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase I Nab-Paclitaxel Plus Gemcitabine With Proton Therapy for Locally Advanced Pancreatic Cancer (LAPC)
Status: RECRUITING
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DRUG: Gemcitabine|RADIATION: Hypofractionated Ablative Proton Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
Status: RECRUITING
Conditions: Aortic Valve Stenosis|Aortic Valve Disease|Aortic Valve Insufficiency|Aortic Valve Replacement
Interventions: DEVICE: EMBLOK™ Embolic Protection System ("EMBLOK EPS")|DEVICE: SENTINEL™ Cerebral Protection System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: L-asparaginase Encapsulated in Red Blood Cells (Eryaspase) for Treatment of Adult Patients With ALL or LBL
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma
Interventions: DRUG: L-asparaginase encapsulated in RBC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ultrasound-guided Internal Jugular Vein Versus Supraclavicular Subclavian Vein Cannulation in Neonates and Infants Less Than 5 kg.
Status: RECRUITING
Conditions: Pediatric|Anesthesia|Central Venous Catheter|Ultrasound|Internal Jugular Vein
Interventions: PROCEDURE: Ultrasound guided SCV cannulation|PROCEDURE: Ultrasound guided IJV cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Susceptibility to Placebo on the Effect of Transcranial Direct Current Stimulation (tDCS) in Fibromyalgia
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibromyalgia
Interventions: DEVICE: s-tDCS|DEVICE: a- tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thermosensitivity of a Topical Palmitated Formulation of Capsaicin
Status: COMPLETED
Conditions: Pain Management
Interventions: DRUG: Capsaicin 0.1% Cream|DRUG: Capsaicin Palmitate 0.25% Cream|DRUG: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open Label Trial of Memantine in the Treatment of Bulimia Nervosa and Body Dysmorphic Disorder
Status: COMPLETED
Conditions: Bulimia Nervosa|Body Dysmorphic Disorder
Interventions: DRUG: Memantine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detecting Cardiac Thrombi in Acute Ischemic Stroke on Cardiac CT Versus Transoesophageal Echocardiography
Status: RECRUITING
Conditions: Ischemic Stroke|Cardioembolic Stroke|Thrombus; Embolism|Left Atrial Thrombosis|Left Atrial Appendage Thrombosis
Interventions: DIAGNOSTIC_TEST: Cardiac Computed Tomography|DIAGNOSTIC_TEST: Transesophageal echocardiography|DIAGNOSTIC_TEST: Repeated Cardiac Computed Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Investigate the Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With Chronic Genotype 1 and 4 HCV Infection With Autoimmune Disease
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: LDV/SOF FDC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cognitive Behavioral Therapy in Treatment of Adults With Attention Deficit Hyperactivity Disorder
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: methylphenidate or amphetamine product|BEHAVIORAL: Cognitive behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Alemtuzumab, and GM-CSF As First-Line Therapy in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: Alemtuzumab|BIOLOGICAL: Rituximab|BIOLOGICAL: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: Metformin|DRUG: Rosiglitazone|BEHAVIORAL: Lifestyle Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduction of Remifentanil-related Complications
Status: NOT_YET_RECRUITING
Conditions: Anesthesia
Interventions: DRUG: Remifentanil (Limited) - Target Controlled Infusion system|DRUG: Remifentanil (Control) - Target Controlled Infusion system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, PK, Dosimetry, MTD and Preliminary Efficacy of Intra-lesionally Injected AvidinOX, Followed by IV Escalating Doses of [177Lu]DOTA-biotin in Pts With Injectable Solid Tumors or Lymphomas
Status: TERMINATED
Conditions: Inoperable Solid Tumors or Lymphomas
Interventions: DRUG: AvidinOX|DRUG: 177Lu-ST2210|DRUG: 177Lu-ST2210
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer|Metastatic Colorectal Cancer
Interventions: DRUG: Onvansertib|DRUG: FOLFIRI|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Registry Assessment of the Missouri Osteochondral Allograft Preservation System - MOPS
Status: ENROLLING_BY_INVITATION
Conditions: Symptomatic Osteochondral Defect(s)|Cartilage, Meniscus, Ankle, Knee, Shoulder, Hip
Interventions: PROCEDURE: Standard of care osteochondral and or meniscal allograft transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Low Dose Aspirin in Increasing the Chance of Pregnancy
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Asprin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects on Plantar Support After Deep Dry Needling in Posterior Tibial Muscle
Status: COMPLETED
Conditions: Movement Disorders
Interventions: PROCEDURE: Deep dry needling in tibialis posterior|PROCEDURE: Sham technique in tibialis posterior
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vertebroplasty In The Treatment Of Acute Fracture Trial - The VITTA Trial
Status: TERMINATED
Conditions: Vertebral Compression Fractures
Interventions: PROCEDURE: Percutaneous vertebroplasty|PROCEDURE: Facet block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2015-10: Expanded Natural Killer Cells and Elotuzumab for High-Risk Myeloma Post- Autologous Stem Cell Transplant (ASCT)
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Elotuzumab|DRUG: Melphalan|PROCEDURE: Autologous Stem Cell Transplant (ASCT)|BIOLOGICAL: Expanded Natural Killer (ENK) Cells|DRUG: ALT-803
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interventional Study of Active Weight Management in Patients With Type 2 Diabetes and Obesity in Routine Clinical Practice During 12 Months.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: BEHAVIORAL: Lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of the Effects of Abdominal Massage and Kinesio Taping in Women With Chronic Constipation
Status: UNKNOWN
Conditions: Constipation
Interventions: OTHER: Suggestions for lifestyle changes+ Abdominal massage|OTHER: Suggestions for lifestyle changes+ Kinesio taping|OTHER: Suggestions for lifestyle changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Pigmented Skin Lesions in Patients With Mastocytosis After Performing 2 Sessions of Pigment Laser
Status: UNKNOWN
Conditions: Cutaneous Mastocytosis
Interventions: DEVICE: Pigment laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional vs. Sensor Guided Soft Tissue Balancing in TKA RCT
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Sensor Guided Soft Tissue Balancing|PROCEDURE: Standard Soft Tissue Balancing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Interventions for Patients With Fibromyalgia and Depression
Status: UNKNOWN
Conditions: Fibromyalgia|Depression
Interventions: BEHAVIORAL: Behavioral activation|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pegylated Liposomal Doxorubicin Combined With Anlotinib for Neoadjuvant Treatment of Soft Tissue Sarcoma
Status: UNKNOWN
Conditions: Stage III Adult Soft Tissue Sarcoma
Interventions: DRUG: Pegylated liposomal doxorubicin|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Personalized Neoantigen Cancer Vaccines
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Colorectal Cancer|Gastroesophageal Adenocarcinoma|Urothelial Carcinoma|Pancreatic Ductal Adenocarcinoma
Interventions: PROCEDURE: Blood collection for research (next-generation sequencing [NGS])|PROCEDURE: Blood collection for research (HLA typing)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Weight Loss Intervention With Lean Muscle Mass Retention
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity
Interventions: COMBINATION_PRODUCT: Low Calorie Animal Protein Meals|COMBINATION_PRODUCT: Low Calorie Plant Protein Meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: SPIN Self-Management Feasibility Trial With Progression to Full-scale Trial (SPIN-SELF)
Status: RECRUITING
Conditions: Scleroderma|Systemic Sclerosis
Interventions: BEHAVIORAL: SPIN-SELF Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Effects of Large Segmental Bone Defects With 3D Printed Titanium Implant
Status: UNKNOWN
Conditions: Large Segmental Bone Defect
Interventions: DEVICE: 3D printed titanium implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study to Evaluate High Flow Nasal Cannula With Monitored Anesthesia Care During EBUS Bronchoscopy
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DEVICE: Vapotherm|DEVICE: Regular nasal canula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of GI BIOTICS 100B UFC to Improve Intestinal Health in Older Adults
Status: NOT_YET_RECRUITING
Conditions: Gut Microbiota|Gut Health|Digestive System|Intestinal Inflammation|Strength
Interventions: DIETARY_SUPPLEMENT: GI BIOTICS 100B UFC|DIETARY_SUPPLEMENT: Placebo Consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Lung Rehabilitation in Treating Patients With Chronic Obstructive Pulmonary Disease Who Are Undergoing Surgery for Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer|Perioperative/Postoperative Complications|Pulmonary Complications|Tobacco Use Disorder
Interventions: BEHAVIORAL: exercise intervention|BEHAVIORAL: smoking cessation intervention|OTHER: counseling intervention|OTHER: educational intervention|PROCEDURE: conventional surgery|PROCEDURE: pulmonary complications management/prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Anagrelide Hydrochloride on Any Changes in Heart Function in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Anagrelide 0.5 mg|DRUG: Anagrelide 2.5 mg|DRUG: Moxifloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Soblidotin and Gemcitabine in Treating Patients With Locally Advanced or Metastatic Solid Tumors
Status: WITHDRAWN
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: gemcitabine|DRUG: soblidotin|PROCEDURE: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery
Status: TERMINATED
Conditions: Post-Operative Delirium|Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: SctO2 < 60 %.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of 19-28z/IL-18 in People With Acute Lymphoblastic Leukemia (ALL)
Status: RECRUITING
Conditions: Philadelphia-Negative ALL|Philadelphia-Positive ALL|Relapsed ALL, Adult|Refractory Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia (ALL)|Refractory Acute Lymphoid Leukemia in Relapse
Interventions: BIOLOGICAL: 19-28z/IL-18 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The COLchicine and Atrial FIBrillation Trial
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combined With Anlotinib and SBRT in Patients With Untreated Brain Metastases of Driven Gene-negative NSCLC
Status: RECRUITING
Conditions: NSCLC
Interventions: DRUG: Toripalimab|DRUG: Anlotinib|DRUG: SBRT 7Gy✖️5 QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Glandular Urethral Disassembly Versus Tubularized Incised Plate for Primary Distal Hypospadius Repair
Status: RECRUITING
Conditions: Glandular Urethral Disassembly|Tubularized Incised Plate|Distal Hypospadius Repair
Interventions: PROCEDURE: Glandular Urethral Disassembly technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Morphological and Serological Criteria of Plaque Vulnerability: Risk Assessment for Symptomatic and Asymptomatic Carotid Artery Stenosis
Status: UNKNOWN
Conditions: Atherosclerosis|Carotid Artery Disease
Interventions: PROCEDURE: Carotid endarterectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Neoadjuvant Chemotherapy Versus Definite Concurrent Chemoradiotherapy for Locally Advanced Bulk Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer|Neoadjuvant Chemotherapy
Interventions: DRUG: gemcitabine and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OstiSense Biosensor in Bruxism Reduction - A Clinical Study
Status: WITHDRAWN
Conditions: Bruxism, Sleep
Interventions: DEVICE: OstiSense biosensor - active|DEVICE: OstiSensor biosensor - not activated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Minocycline in Intracerebral Hemorrhage
Status: COMPLETED
Conditions: Intracerebral Hemorrhage
Interventions: DRUG: Minocycline|OTHER: normal saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Natureheme-iron on Iron Absorption Effect and Anti-oxidation Functions
Status: COMPLETED
Conditions: Anemia
Interventions: DIETARY_SUPPLEMENT: Natureheme-iron|DIETARY_SUPPLEMENT: Placebo|DRUG: supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Entospletinib (ENTO) as Monotherapy and in Combination With Chemotherapy in Japanese Adults
Status: TERMINATED
Conditions: Hematologic Malignancy|Acute Myeloid Leukemia
Interventions: DRUG: Entospletinib|DRUG: Daunorubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Pharmacodynamics and Pharmacokinetics of Biphasic Insulin Aspart 30, 50, 70 and Insulin Aspart in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 50|DRUG: biphasic insulin aspart 70|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Music Therapy Advocacy Recording Intervention (MTAR) on Internalized Stigma
Status: TERMINATED
Conditions: Mental Health Issues|Bipolar Disorder|Depressive|Schizophrenia Spectrum and Other Psychotic Disorders|Anxiety Disorder
Interventions: BEHAVIORAL: Group Music Therapy Advocacy Recording Intervention (MTAR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of the Effectiveness of Povidone-iodine in Reducing Conjunctival Bacterial Load Prior to Cataract Surgery in Patients Treated With a Lidocaine Gel Dilating Formulation Versus Eye Drops: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Cataracts
Interventions: DRUG: topical povidone-iodine after premedication with topical liquid eye drops|DRUG: topical povidone-iodine after premedication with topical gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Estrogen for Postpartum Depression
Status: TERMINATED
Conditions: Postpartum Depression|Depression
Interventions: DRUG: 17beta Estradiol|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Jaeumgeonbi-Tang on Chronic Subjective Dizziness
Status: TERMINATED
Conditions: Chronic Subjective Dizziness
Interventions: DRUG: JGT (Jaeumgeonbi-Tang) tablet|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supracondylar Post-Operative Pain Study
Status: RECRUITING
Conditions: Supracondylar Humerus Fracture
Interventions: DRUG: Ibuprofen|DRUG: Oxycodone|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Triple Therapy With Palonosetron for PON Prophylaxis
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Palonosetron 0.075 mg IV|DRUG: Dexamethasone 10 mg IV|DRUG: Promethazine 25 mg IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment Of Sildenafil On Erectile Function And Intercourse Satisfaction And To Validate A New Subject Questionnaire
Status: COMPLETED
Conditions: Impotence
Interventions: DRUG: sildenafil citrate|DRUG: placebo for sildenafil citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of Ipratropium Bromide Associated With High Dose Salbutamol by Repeated Nebulisation Versus Repeat Nebulisation of Salbutamol Alone, in Acute Asthmatic Attacks in Young Children
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: Ipratropium bromide|DRUG: Placebo|DRUG: Salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: [18F]FMISO PET/CT After Transcatheter Arterial Embolization in Imaging Tumors in Patients With Liver Cancer
Status: COMPLETED
Conditions: Adult Liver Carcinoma|Liver Cirrhosis
Interventions: DRUG: 18F-Fluoromisonidazole|PROCEDURE: Arterial Embolization|DIAGNOSTIC_TEST: Computed Tomography|DIAGNOSTIC_TEST: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment for Joint Pains Due to Aromatase Inhibitor Therapy in Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer|Arthralgia|Joint Pain
Interventions: OTHER: Women without Arthralgia|DRUG: Women with Arthralgia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-extubation Boussignac CPAP System in Adults With Moderate to Severe Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: DEVICE: Boussignac CPAP device|DEVICE: standard CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery
Status: UNKNOWN
Conditions: Edema|Ecchymosis; Eyelid
Interventions: DRUG: Tranexamic acid injection|OTHER: Local anesthetic control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Psychological Treatment for Pain After Breast Cancer: A Pilot Study
Status: COMPLETED
Conditions: Pain, Chronic|Breast Cancer
Interventions: BEHAVIORAL: Mindful attention|BEHAVIORAL: Decentering|BEHAVIORAL: Value-based action
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Status: RECRUITING
Conditions: Dehydration|Rehydration|Exercise Performance|Exercise Recovery|Cognitive Performance
Interventions: OTHER: TP1|OTHER: TP2|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Safety and Efficacy Evaluation of XSLJZ in Advanced Hepatocellular Carcinoma Patients With Multiple Protein Kinase Inhibitor Therapy: A Randomized, Double-Blind, Controlled Trial
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Xiang Sha Liu Jun Zi Decoction dry powder|DRUG: XSLJZ Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging Guided Cementoplasty for Pelvic Bone Metastasis
Status: NOT_YET_RECRUITING
Conditions: Imaging Guided|Percutaneous Cementoplasty|Pelvic Bone Metstasis
Interventions: PROCEDURE: Percutaneous cementoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of Zymar Versus Vigamox for Preoperative Sterilization of the Ocular Surface After Loading Dose
Status: UNKNOWN
Conditions: Eye Infection|Infection
Interventions: DRUG: Moxifloxacin ophthalmic solution 0.5%|DRUG: Gatifloxacin ophthalmic solution 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Candidiasis, Vulvovaginal
Interventions: DRUG: Clotrimazole vaginal tablet|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Of Pegaptanib Sodium (EYE001) For Wet-Type Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: pegaptanib sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Renal Cell
Interventions: DRUG: Belzutifan|BIOLOGICAL: Pembrolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer|Oropharynx Cancer|Larynx Cancer|Hypopharynx Cancer
Interventions: DRUG: Motexafin Gadolinium Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology
Status: WITHDRAWN
Conditions: Iritis
Interventions: DRUG: Euphrasia|DRUG: Prednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Socket Preservation Using Autogenous Dentine Graft With Or Without Autologous Fibrin Glue
Status: NOT_YET_RECRUITING
Conditions: Unrestorable Dentition
Interventions: PROCEDURE: dentin graft mixed with autologous fibrin glue|PROCEDURE: dentin graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer
Status: RECRUITING
Conditions: AIDS-Related Anal Carcinoma|Anal Basaloid Squamous Cell Carcinoma|Anal Canal Cloacogenic Carcinoma|Anal Margin Squamous Cell Carcinoma|Anal Squamous Cell Carcinoma|HIV Infection|Rectal Squamous Cell Carcinoma|Stage I Anal Cancer AJCC v8|Stage II Anal Cancer AJCC v8|Stage II Rectal Cancer AJCC v8|Stage III Anal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8
Interventions: DRUG: Capecitabine|DRUG: Fluorouracil|RADIATION: Intensity-Modulated Radiation Therapy|DRUG: Mitomycin|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEARL Schizophrenia Maintenance
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Lurasidone|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Novel Point of Care Hepatitis B Diagnostic Assays
Status: WITHDRAWN
Conditions: Hepatitis B
Interventions: DIAGNOSTIC_TEST: Xpert® HBV DNA fingerstick point of care assay|DIAGNOSTIC_TEST: Point of Care ALT|DIAGNOSTIC_TEST: Xpert® HBV DNA point of care assay from dried blood spot
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Risedronate in the Treatment of Osteogenesis Imperfecta in Children
Status: COMPLETED
Conditions: Osteogenesis Imperfecta
Interventions: DRUG: risedronate sodium (Actonel)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Volumetric Dimensional Changes After Surgical Pontic Site Development Procedures With Connective Tissue Graft or Collagen Matrix
Status: NOT_YET_RECRUITING
Conditions: Connective Tissue Graft|Volume Collagen Matrix Xenograft
Interventions: DEVICE: Geistlich Fibro-Gide®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Atezolizumab With Paclitaxel, Trastuzumab, and Pertuzumab in Patients With Metastatic HER-2 Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Atezolizumab|DRUG: Paclitaxel|DRUG: Trastuzumab|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Recombinant Human Arginase 1 (rhArg1) in Patients With Relapsed or Refractory Leukemia or Lymphoma
Status: TERMINATED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: Recombinant human arginase 1 Peg5000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b, Open-Label Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of EP262 in Subjects With Chronic Inducible Urticaria
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Inducible Urticaria
Interventions: DRUG: Oral EP262
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Applied to Platinum-Resistant Recurrence of Ovarian Tumor
Status: COMPLETED
Conditions: Ovarian Epithelial Cancer Recurrent|Platinum-resistant
Interventions: DEVICE: Pressurized intraperitoneal aerosol chemotherapy with cisplatin and doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Implementation of Primary HPV Testing in the Organized Screening for Cervical Cancer in Stockholm
Status: ACTIVE_NOT_RECRUITING
Conditions: High-grade Cervical Intraepithelial Neoplasia|Invasive Cervical Cancer
Interventions: OTHER: HPV testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: To Demonstrate the Relative Bioavailability Study of Ondansetron HCl 24 mg Tablets Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Ondansetron HCl 24 mg Tablets (Sandoz, Inc.)|DRUG: Zofran (Ondansetron HCl) 24 mg Tablets (GlaxoSmithKline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT