pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Apatinib Plus Docetaxel Versus Docetaxel as Second-line Treatment in Advanced Gastric Cancer (AHEAD-301)
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Apatinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyrotinib in Breast Cancer Patients With Poor Response to the Neoadjuvant Treatment of Trastuzumab and Pertuzumab
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics
Status: COMPLETED
Conditions: Atrial Fibrillation|Deep Vein Thrombosis|Cardiac Valvular Insufficiency|Coagulopathies|Pulmonary Embolism
Interventions: GENETIC: Genotype-guided|OTHER: Standard-of-Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate an Implant With a Sloped Top in Patients With a Sloped Jaw Bone
Status: COMPLETED
Conditions: Edentulism
Interventions: DEVICE: ASTRA TECH Implant System, OsseoSpeed™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
Status: TERMINATED
Conditions: Epilepsy|Epilepsy in Children|Epilepsy; Seizure|Disease|Brain Diseases|Central Nervous System Diseases|Nervous System Diseases|Epileptic Syndromes
Interventions: DRUG: XEN496|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of CALPXT96™in Improving Sleep Quality in Patients With Chronic Non-cancer Pain
Status: WITHDRAWN
Conditions: Chronic Pain|Insomnia
Interventions: DRUG: CALPXT96
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Acute Effects of LSD, Psilocybin and Mescaline
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LSD|DRUG: Psilocybin|DRUG: Mescaline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Virtual Reality for the Improvement of Patients Understanding of Disease and Treatment (MRgRT)
Status: WITHDRAWN
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Computed Tomography|OTHER: Best Practice|OTHER: Questionnaire Administration|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Computed Tomography|OTHER: Virtual Technology Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bevacizumab, Temozolomide and Hypofractionated Radiotherapy for Patients With Newly Diagnosed Malignant Glioma
Status: COMPLETED
Conditions: Brain Cancer|Malignant Glioma
Interventions: OTHER: radiotherapy (RT) in combination with temozolomide and bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RADAR Trial - Randomised Androgen Deprivation and Radiotherapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprorelin Acetate|DRUG: Zoledronic Acid|RADIATION: Conventional external beam therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Fluid Responsiveness by NICOM (Non-invasive Cardiac Output Monitoring) in Children With Congenital Heart Disease After Cardiac Surgery
Status: COMPLETED
Conditions: Fluid Responsiveness
Interventions: OTHER: volume expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Urolift Pre-SBRT for Reduced Urinary Toxicity in Patients With BPH and Prostate Cancer.
Status: SUSPENDED
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Urolift
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Burn Glove Trial - Hand Burn Dressing Pilot
Status: WITHDRAWN
Conditions: Burns
Interventions: OTHER: Aquacel® Ag Burn Glove|OTHER: Mepilex® Transfer Ag|DRUG: antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extraperitoneal Para-aortic Lymph Node Dissection (EPLND) for Cervix
Status: COMPLETED
Conditions: Cervical Squamous Cell Carcinoma|Adenosquamous Carcinoma|Adenocarcinoma|Locally Advanced Malignant Neoplasm|Cervical Cancer
Interventions: PROCEDURE: Extraperitoneal laparoscopic lymphadenectomy (EPLND)|RADIATION: Chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating New Nicotine Standards for Cigarettes - Project 3
Status: COMPLETED
Conditions: Smoking, Cigarette|Electronic Cigarettes
Interventions: BEHAVIORAL: Spectrum Research Cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Common Topical Glaucoma Therapy on Optic Nerve Head Blood Flow Autoregulation During Increased Arterial Blood Pressure and Artificially Elevated Intraocular Pressure in Healthy Humans
Status: WITHDRAWN
Conditions: Glaucoma
Interventions: DRUG: Timolol (drug)|DRUG: dorzolamide (drug)|DRUG: brimonidine (drug)|DEVICE: Laser Doppler flowmetry|DEVICE: Goldmann applanation tonometer|PROCEDURE: Suction cup method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vasopressin and Pain Perception in the Brain
Status: RECRUITING
Conditions: Acute Pain
Interventions: DRUG: Arginine vasopressin|OTHER: Saline|BEHAVIORAL: Observational learning|OTHER: fMRI data aquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quality of Life in Patients With Double Loop Ureteral Stent (JJ Silicone Hydrogel Study)
Status: UNKNOWN
Conditions: Kidney Calculi
Interventions: DEVICE: Double Loop Ureteral stent endoscopic placement.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Focal Laser Ablation of Low to Intermediate Prostate Cancer Tumors
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Adenocarcinoma|Stage I Prostate Cancer AJCC v8|Stage II Prostate Cancer AJCC v8|Localized Prostate Carcinoma
Interventions: PROCEDURE: Focal laser ablation of the prostate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet-rich Plasma Infiltration Versus Corticosteroid Infiltration (Prednisolone) in Treatment of Lumbar Facet Joint Syndrome
Status: COMPLETED
Conditions: Low Back Pain|Osteoarthritis
Interventions: DRUG: Prednisolone|DRUG: Platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Internal vs. External Connection in Screw-retained Multi-units Bridges With Cad/Cam Milled Co/Cr Framework (ISUS-Atlantis)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rehabilitation of Edentulous Area With an Implant Level Set-up
Interventions: DEVICE: Internal vs. external cad cam co/cr framework
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing for Vaccine Uptake in Latinx Adults
Status: ENROLLING_BY_INVITATION
Conditions: Vaccine Hesitancy
Interventions: OTHER: EHR alert|BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Warm hand off to nurse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Preventing Bone Loss Among Chinese Patients With HIV on ART
Status: UNKNOWN
Conditions: HIV/AIDS|Osteoporosis|Bone Loss
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fibrinogen Concentrate (Human) - Efficacy and Safety Study
Status: WITHDRAWN
Conditions: Afibrinogenemia|Hypofibrinogenemia|Fibrinogen Deficiency
Interventions: BIOLOGICAL: Fibrinogen Concentrate, Human (FCH)|BIOLOGICAL: Cryoprecipitate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Afatinib and Selumetinib in Advanced KRAS Mutant and PIK3CA Wildtype Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Gastrointestinal Neoplasms|Pancreatic Neoplasms|Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Afatinib|DRUG: Selumetinib|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-omics Study of Epithelial Ovarian Cancer
Status: UNKNOWN
Conditions: Epithelial Ovarian Cancer|Tumor Invasiveness|Whole Exome Sequencing|Transcriptomics|Metabolomics|Tumorigenesis
Interventions: COMBINATION_PRODUCT: A multi-omics analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of DAbigatran and RIvaroxaban Versus NAdroparin in the Prevention of Venous Thromboembolism After Knee Arthroplasty Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Dabigatran|DRUG: Rivaroxaban|DRUG: Nadroparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Effect of Telmisartan/S-amlodipine on the Pharmacokinetic Properties of Atorvastatin.
Status: COMPLETED
Conditions: Essential Hypertension|Hyperlipidemia
Interventions: DRUG: Telmisartan 80mg, S-amlodipine 5mg and Atorvastatin 40mg|DRUG: atorvastatin 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Knee Replacements for Patellofemoral Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Knee arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Titration of Continuous Positive Airway Pressure Could Predict Success of Oral Appliance to Treat Sleep Apnea
Status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Interventions: PROCEDURE: Oral appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Dissemination of Oral Health Risk Assessment and Referral Guidelines
Status: WITHDRAWN
Conditions: Early Childhood Dental Caries
Interventions: BEHAVIORAL: Development and dissemination of priority oral health risk assessment and referral guidelines - PORRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Evaluate the Drug-drug Interaction Between Telmisartan and Atorvastatin in Healthy Male Volunteers
Status: COMPLETED
Conditions: Diseases of the Circulatory System|Essential Hypertension
Interventions: DRUG: Telmisartan|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Duloxetine as a Premedication for Postoperative Pain Control
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Duloxetine 60mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure.
Status: UNKNOWN
Conditions: Respiratory Insufficiency|Chronic Obstructive Pulmonary Disease|Pneumonia|Pulmonary Edema|Neuromuscular Diseases
Interventions: DEVICE: Non-invasive positive pressure mask ventilators|DEVICE: Extrathoracic biphasic cuirass ventilator (RTX, Hayek)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Laparoscopic Suturing Versus Bipolar Coagulation on Ovarian Reserve in Patients Undergoing Endometriotic Ovarian Cystectomy.
Status: UNKNOWN
Conditions: Ovary Injury
Interventions: DEVICE: 2-0 polyglican absorbable sutures|DEVICE: Diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Leaf Extract of Azadirachta Indica in Palmer Arsenical Keratosis
Status: COMPLETED
Conditions: Arsenical Keratosis
Interventions: OTHER: Leaf extract of A. indica|DRUG: Salicylic Acid (6%)|OTHER: Petroleum jelly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetics of Alcohol: Treatment Implications
Status: COMPLETED
Conditions: Alcohol Related Disorders|Alcoholism|Alcohol Abuse
Interventions: DRUG: dutasteride + ethanol|DRUG: placebo medication + ethanol|DRUG: dutasteride + placebo alcohol|DRUG: placebo medication + placebo alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Comparison of Effectiveness of TissuePatchTM in Preventing Postoperative Pancreatic Fistula
Status: RECRUITING
Conditions: Pancreatic Fistula
Interventions: OTHER: Radical gastrectomy +D2 lymphadenectomy+TissuePatchTM to seal pancreatic tissue surface|OTHER: Radical gastrectomy +D2 lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Ad26.ZEBOV Booster in Children Previously Vaccinated With Ad26.ZEBOV and MVA-BN-Filo (EBOVAC Booster Study)
Status: COMPLETED
Conditions: Ebola Virus Disease
Interventions: DRUG: Ad26.ZEBOV booster vaccination, given at a dose of 5x10^10 vp, via IM injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Chemotherapy Combined With Regional Hypothermia in Advanced Malignant Melanoma Patients With Progressive Soft Tissue Metastases
Status: UNKNOWN
Conditions: Advanced Metastastic Malignant Melanoma|Refractory to First-Line Chemotherapy Irresectable Progressive Soft Tissue Metastases
Interventions: DEVICE: hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: lonafarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Provider-Initiated Regular Remote Interventions for Optimal Type 2 Diabetes Care
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Remote, personalized type 2 diabetes care.|OTHER: Usual Endocrine care.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colon Adenocarcinoma|Metastatic Colorectal Carcinoma|Metastatic Rectal Adenocarcinoma|Stage III Colon Cancer AJCC v8|Stage III Colorectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8|Stage IIIA Colon Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Colon Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Colon Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8|Stage IV Colon Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IV Rectal Cancer AJCC v8|Stage IVA Colon Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVA Rectal Cancer AJCC v8|Stage IVB Colon Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVB Rectal Cancer AJCC v8|Stage IVC Colon Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8|Stage IVC Rectal Cancer AJCC v8|Unresectable Colon Adenocarcinoma|Unresectable Colorectal Carcinoma|Unresectable Rectal Adenocarcinoma
Interventions: BIOLOGICAL: Panitumumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Regorafenib|DRUG: Trifluridine and Tipiracil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
Status: NOT_YET_RECRUITING
Conditions: Distal Radius Fractures
Interventions: DRUG: Topical TRanexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Local Infiltration Analgesia With Ropivacaine Versus Placebo in Vaginal Hysterectomy: a Randomized, Double-Blind Study
Status: COMPLETED
Conditions: Pain, Postoperative|Postoperative Nausea and Vomiting
Interventions: DRUG: Ropivacaine 0.5 %|DRUG: Isotonic NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Performance of Different Application Regimens of ACTINICA® on Protection From UVR-induced Erythema After One Day of Sun Exposure in Fair-skinned Healthy Subjects.
Status: COMPLETED
Conditions: Healthy Subjects, Male or Female, of 18-60 Years Old, With Phototype I, II or III, Not Pre-treated/Pre-protected Skin
Interventions: DEVICE: Actinica, 0.8 mg/cm2, 1 application|DEVICE: Actinica, 0.8 mg/cm2, 2 applications|DEVICE: Actinica, 2 mg/cm2, 1 application|DEVICE: Actinica, 2 mg/cm2, 2 applications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Decision Support Interventions (DESI) for Prostate Cancer Screening - Study 1
Status: COMPLETED
Conditions: Healthy Men Age 50 Who Are Considering PSA Screening
Interventions: BEHAVIORAL: DESI for home viewing|BEHAVIORAL: DESI for viewing at Shared Medical Appointment|BEHAVIORAL: Option of SMA and DESI or DESI only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: IN10018 Monotherapy and Combination Therapy for Metastatic Melanoma
Status: RECRUITING
Conditions: Metastatic Melanoma
Interventions: DRUG: IN10018|DRUG: Cobimetinib|BIOLOGICAL: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors
Status: TERMINATED
Conditions: Head and Neck Cancer|Islet Cell Tumor|Metastatic Cancer|Pheochromocytoma
Interventions: DRUG: octreotide acetate|RADIATION: yttrium Y 90 resin microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Rehabilitation Program to Increase Balance and Mobility in Ataxia of Charlevoix-Saguenay
Status: COMPLETED
Conditions: Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay
Interventions: OTHER: Training program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Comparing Rituximab/Bendamustin(RB) Alternating With Rituximab/Bendamustin/Cytarabin(RBAC) With RB Therapy in Elderly Patients With Mentle Cell Lymphoma
Status: RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: RB/RBAC alternating|DRUG: RB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idroflog® for Treatment of Dry Eye Disease (IDROFLOG)
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease
Interventions: DEVICE: Idroflog®|DEVICE: Sodium Hyaluronate 0.18% (Vismed®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of MEK (Trametinib) and BRAFV600E (Dabrafenib) Inhibitors With Radioactive Iodine (RAI) for the Treatment of Refractory Metastatic Differentiated Thyroid Cancer
Status: UNKNOWN
Conditions: Metastatic Radioactive Iodine Refractory Thyroid Cancer Patients With RAS or BRAF Mutation
Interventions: DRUG: Trametinib|DRUG: Dabrafenib|RADIATION: 131I|DRUG: rhTSH
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PAHTCH Pulmonary Arterial Hypertension Treatment With Carvedilol for Heart Failure (Carvedilol)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Carvedilol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of iPD1 CD19 eCAR T Cells in Relapsed or Refractory B-cell Lymphoma
Status: UNKNOWN
Conditions: Relapsed or Refractory B-cell Lymphoma
Interventions: BIOLOGICAL: iPD1 CD19 eCAR T cells|DRUG: Fludarabine and cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 TAK-906 Single and Multiple Ascending Dose Study in Japanese Healthy Male Participants
Status: COMPLETED
Conditions: Japanese Healthy Adult Male Participants
Interventions: DRUG: TAK-906|DRUG: TAK-906 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Sunscreen: Persistence of Sun Protection Factor and the Influence on Vitamin D
Status: UNKNOWN
Conditions: Vitamin D Production in the Skin|Sunscreen Persistence
Interventions: OTHER: sunscreen MATAS sunlotion SPF 8|RADIATION: UVB light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RESOLUTE Asia: Evaluation of the Endeavor Resolute Zotarolimus-Eluting Stent System in a Patient Population With Long Lesion(s) and/or Dual Vessels in Asia
Status: COMPLETED
Conditions: Ischemic Heart Disease|Coronary Stenosis|Cardiovascular Diseases|Arteriosclerosis|Coronary Artery Disease
Interventions: DEVICE: Drug eluting stent treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurements of Water in Breath and Saliva
Status: ENROLLING_BY_INVITATION
Conditions: Human Energy Expenditure
Interventions: PROCEDURE: Feasibility of measuring 2H:1H and 18O:16O in saliva and breath.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Clinical Application of Clostridium Butyricum Miyairisan for Motor and Non-motor Symptoms in Parkinson's Disease
Status: RECRUITING
Conditions: Clostridium Butyricum Miyairi|Parkinson Disease
Interventions: DRUG: Miyarisan-BM (Clostridium Butyricum Miyairi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of Safety and Biological Effects of C326, an Inhibitor of IL-6, in Crohn's Disease
Status: UNKNOWN
Conditions: Crohn's Disease
Interventions: DRUG: C326, IL-6 Inhibitory Avimer protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Early Identification and Severity Prediction of Acute Respiratory Infectious Disease
Status: RECRUITING
Conditions: Acute Respiratory Infection|Severe Pneumonia|Next Generation Sequencing|Multiplex PCR
Interventions: DIAGNOSTIC_TEST: mNGS|DIAGNOSTIC_TEST: Multiplex PCR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury Risk
Status: NOT_YET_RECRUITING
Conditions: Occupational Injuries|Heat Stress|Leg Injury|Back Injuries
Interventions: OTHER: Rapid Heat Condition|OTHER: Gradual Heat Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Open-label Study of Low-dose Ketamine Infusion Treatment in Levodopa-Induced Dyskinesia in Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Levodopa-Induced Dyskinesia|Parkinson's Disease
Interventions: DRUG: Intervention: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-time Interactive Digital Healthcare System in Patients With Breast Cancer; Randomized Controlled Trial
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Uincare Homeplus|OTHER: Brochure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: [18F]Florbetazine ([18F]92) for Beta Amyloid PET Imaging in Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: DRUG: [18F]Florbetazine ([18F]92)|DRUG: [11C]PIB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients
Status: RECRUITING
Conditions: Adenocarcinoma of the Pancreas
Interventions: DRUG: Valproic acid|DRUG: Simvastatin 20mg|DRUG: Gemcitabine 1000 mg|DRUG: Nab paclitaxel|DRUG: Cisplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Efficacy of Corticosteroids and Mycophenolate Mofetil in Patients With Immune Related Hepatitis
Status: RECRUITING
Conditions: Hepatitis, Drug-Induced
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Solu-Medrol|DRUG: Ursodeoxycholic acid|DRUG: Prednisone tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prognostic Value of Biomarkers and the Effect of Tolperisone in Acute Low Back Pain and Sciatic Pain "BETA"
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Back Pain
Interventions: DRUG: Tolperisone Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma
Status: WITHDRAWN
Conditions: Thyroid Carcinoma|Hypothyroidism
Interventions: OTHER: Black Coffee|OTHER: Coffee with Milk|OTHER: Black Tea|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of HYR-PB21 in Healthy Volunteers
Status: COMPLETED
Conditions: Acute Postoperative Pain
Interventions: DRUG: HYR-PB21|DRUG: Liposomal bupivacaine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Advanced Periodontitis Using an Oscillating Chitosan Device Versus Regular Curettes Alone
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DEVICE: Labrida Bioclean|DEVICE: Gracey Periodontal curettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Ganglionated Plexi Ablation Guided by the SUMO Technology With and Without Conventional Pulmonary Vein Isolation in Patients With Persistent AF
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: Pulmonary vein isolation|DEVICE: GP ablation guided by SUMO technology|DEVICE: ILR implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ipratropium or Salbutamol Sulphate Alone or Combination Therapy Salbutamol and Ipratropium in Patients With COPD
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Ipratropium bromide 500 µg/salbutamol sulphate 3 mg|DRUG: Ipratropium 500 µg|DRUG: Salbutamol sulphate 3 mg|DRUG: Salbutamol sulphate 6 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of Mindfulness-based Cognitive Therapy and Major Depressive Disorder
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: BEHAVIORAL: Mindfulness-based Cognitive Therapy|DRUG: Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sugammadex Given for the Reversal of Rocuronium Induced Neuromuscular Blockade Under Sevoflurane Anesthesia in Infants
Status: COMPLETED
Conditions: Brain Cancer
Interventions: DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of SHR6390 in Combination With Fulvestrant in Patients With HR Positive and HER2 Negative Advanced Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: SHR6390|DRUG: Placebo|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicohort Phase II Trial of sEphB4-HSA+Pembrolizumab in Solid Tumors
Status: RECRUITING
Conditions: Stage IV Bladder Urothelial Carcinoma|Prostate Cancer|Urothelial Carcinoma
Interventions: PROCEDURE: Computed Tomography|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Recombinant EphB4-HSA Fusion Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AAVCAGsCD59 for the Treatment of Wet AMD
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: Intravitreal anti-VEGF|BIOLOGICAL: Intravitreal AAVCAGsCD59|DRUG: Oral prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Failed Endometrial Ablation Treatment With Implantable Progesterone (FEAT) Study
Status: TERMINATED
Conditions: Abnormal Uterine Bleeding|Dysmenorrhea
Interventions: DRUG: Etonogestrel 68mg implant|DEVICE: Etonogestrel 68mg implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Donor Testing Kit for the Prediction of AGVHD in Patient Receiving a Peripheral Blood Stem Cell Allograft
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia in Remission|Lymphoma in Remission|Non-progressive Myeloproliferative Syndrome|Myelodysplasia With Stable Blasts is Cell Number and < 10% of Blastocysts|Acute Leukemia Biphenotypic in Remission|Acute Lymphoblastic Leukemia
Interventions: DIAGNOSTIC_TEST: Ex vivo capacities of CD4neg INkT expansion of the peripheral blood donor with the Predictor test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Limiting AAA With Metformin (LIMIT) Trial
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: DRUG: Metformin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Plug Arterial Closure System (PACS, 7F)
Status: COMPLETED
Conditions: Angioplasty, Transluminal, Percutaneous Coronary|Coronary Arteriosclerosis
Interventions: DEVICE: Vascular access site closure (7F Ensure)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and of Stillen Tab. and to Demonstrate the Non-inferiority of Stillen Tab.
Status: COMPLETED
Conditions: Acute Gastritis|Chronic Gastritis
Interventions: DRUG: Stillen Tab.|DRUG: Mucosta Tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Participants With Ichthyosis
Status: TERMINATED
Conditions: Ichthyosis
Interventions: DRUG: Imsidolimab|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ranolazine on Echocardiographic Indices of Diastolic Dysfunction
Status: TERMINATED
Conditions: Ranolazine|Diastolic Heart Failure|Tissue Doppler Ultrasound|Echocardiography
Interventions: DRUG: ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Cord Blood Mononuclear Cells in the Treatment of Refractory Diabetic Foot
Status: RECRUITING
Conditions: Refractory Diabetic Foot|Human Cord Blood-derived Mononuclear Cells|Efficacy|Safety|Local Injection
Interventions: BIOLOGICAL: human cord blood-derived mononuclear cells (HCB-MNCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Obesity Pharmacotherapy
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Phentermine-Topiramate|DRUG: Liraglutide|DRUG: Naltrexone/bupropion|DRUG: Phentermine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2a Two-Arm Dose-Escalation Study of BAX69 in Subjects With Malignant Ascites of Ovarian Cancer
Status: TERMINATED
Conditions: Refractory Ovarian Cancer With Recurrent Symptomatic Malignant Ascites
Interventions: BIOLOGICAL: BAX69 Single-Route Arm|BIOLOGICAL: BAX69 Double-Route Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Salmeterol on Fluid Clearance From Alveolar-Capillary Membrane in COPD Patients
Status: COMPLETED
Conditions: Salmeterol Effect Against an Acute Alveolar Fluid Clearance Challenge Secondary to Lung Fluid Overload in COPD Patients|Chronic Obstructive Pulmonary Disease|Bronchodilator Agents|Salmeterol
Interventions: DRUG: Salmeterol|PROCEDURE: saline infusion (0.9 per cent sodium chloride)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quadratus Lumborum Block Versus Erector Spinae Plane Block in Extracorporeal Shock Wave Lithotripsy(ESWL)
Status: RECRUITING
Conditions: Pain|Lithiasis
Interventions: PROCEDURE: Quadratus lumborum block type III|PROCEDURE: Erector spinae plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profiles of Metformin With DW1029M
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DW1029M 1200mg and Metformin 1000mg|DRUG: Metformin 1000mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Visa-versa! Breaking Instead of Pushing the Pedals-B
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: 15 minutes eccentric cycling|PROCEDURE: 15 minutes concentric (normal) cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prostate Interstitial Brachytherapy With I125 Implant With Target Dose Supplementation in the Tumor Volume Guided by TRINITY® PERINE 3D System
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: OTHER: Interstitial Brachytherapy of the Prostate With Iodine 125 Implant With Target Dose Supplementation in the Tumor Volume Guided by the TRINITY® PERINE 3D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prenatal Affective Cognitive Training to Reduce the Risk of Postpartum Depression (PACT)
Status: RECRUITING
Conditions: Postpartum Depression|Emotional Regulation|Cognitive Function 1, Social|Pregnancy Related|Mother-Child Relations
Interventions: OTHER: Prenatal Affective CogntiiveTraining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Development of a New Non-radioactive Test for Measuring Glomerular Filtration Rate Using the Tetrapeptide N-acetyl-Ser-Asp-Lys-Pro-amide (AcSDKP-NH2)
Status: COMPLETED
Conditions: Healthy|Chronic Kidney Disease
Interventions: DRUG: AcSDKP-NH2 inuline|DRUG: AcSDKP-NH2 Cr-EDTA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Citalopram on Chest Pain in Patients With Functional Chest Pain
Status: TERMINATED
Conditions: Functional Chest Pain
Interventions: DRUG: Citalopram 20mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sensomotoric Insoles on Postural Control in Elderly People
Status: COMPLETED
Conditions: Sensorimotor Gait Disorder
Interventions: DEVICE: sensomotoric insoles|DEVICE: normal standard insoles|OTHER: No insoles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab in the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Immune Checkpoint Inhibitors
Interventions: DRUG: Cadonilimab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Patients With Pediatric Solid Tumors (GAP)
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Cancer
Interventions: GENETIC: GAP T cells|DRUG: Cytoxan|DRUG: Fludara
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: ATM Gene Mutation|BRCA1 Gene Mutation|BRCA2 Gene Mutation|Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Homologous Recombination Deficiency|Prostate Carcinoma Metastatic in the Bone|PSA Level Greater Than or Equal to Two|PSA Progression|Stage IV Prostate Adenocarcinoma AJCC v7
Interventions: DRUG: Carboplatin|DRUG: Docetaxel|OTHER: Laboratory Biomarker Analysis|DRUG: Rucaparib Camsylate|DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aflibercept Plus Micropulse Laser Versus Aflibercept Monotherapy for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DEVICE: micropulse laser|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Gut Peptides on Bone Remodeling. KS-4-Diabetes-19
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: OTHER: GLP-2|OTHER: GIP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Research Study of How Overdosing of a New Once Weekly Medicine NNC0148-0287 C (Insulin 287) Influences the Blood Sugar Level in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: insulin icodec|DRUG: Insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors
Status: COMPLETED
Conditions: Melanoma|Lung Cancer|Renal Cell Carcinoma|Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Recombinant Vaccinia GM-CSF; RAC VAC GM-CSF (JX-594)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rural Expanded Access to OUD Care & Linkage Using Toxicologists for Telehealth Initiated Treatment
Status: RECRUITING
Conditions: Opioid Use|Opioid Abuse
Interventions: BEHAVIORAL: Sociobehavioral Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Hepatectomy Combined With Targeted Therapy and Immunotherapy for Advanced Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: PROCEDURE: Palliative Hepatectomy|DRUG: Durvalumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability and Pharmacokinetics of Orally-administered GC4702 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GC4702 dry powder|DRUG: GC4702 lipid suspension|OTHER: GC4419 IV|OTHER: Placebo Dry Powder|OTHER: Placebo lipid suspension|OTHER: Fed Condition|OTHER: Fasting Condition|DRUG: GC4702 lipid suspension - Part 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Anchorage Loss During En-masse Retraction in Orthodontic Patients With Maxillary Protrusion
Status: UNKNOWN
Conditions: Bimaxillary Protrusion
Interventions: PROCEDURE: Power chain and Crimpable hook fro En-masse Retraction|PROCEDURE: T-loop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Folfiri/aflIbercept in Metastatic coloreCTal Cancer patIents With RAS Validated Wild typE Status
Status: UNKNOWN
Conditions: Advanced Colorectal Cancer
Interventions: PROCEDURE: Aflibercept, 5fluorouracil, Folinic Acid andIrinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dermacyd PH_DETINLYN Tangerine Mix (Lactic Acid) - Photo Evaluation
Status: COMPLETED
Conditions: Hygiene
Interventions: DRUG: Lactic Acid (Dermacyd PH_DETINLYN Tangerine Mix)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intubating Condition After Magnesium Pre-treatment
Status: COMPLETED
Conditions: Easy of Laryngoscopy Manipulation|Vocal Cord Position or Movement|Patient Reaction to Intubation and Cuff Inflation|Mean Arterial Pressure|Heart Rate
Interventions: DRUG: magnesium sulphate|DRUG: normal saline|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Prontosan Quality of Life Study in Patients With Chronic Leg Wound(s)
Status: TERMINATED
Conditions: Wound of Lower Leg (Physical Finding)
Interventions: DEVICE: Prontosan Wound Irrigation Solution and Prontosan Wound Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT