pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Parent-implemented Social Communication Treatment in Preschool Children With Autism Spectrum Disorder
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism|Social Communication|Speech Therapy|Parenting|Autism Spectrum Disorder
Interventions: BEHAVIORAL: Group-based Parent-implemented Social Communication Training|BEHAVIORAL: Self-learning-based Parent-implemented Social Communication Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Steady State TPV/r on Intracellular Concentrations of Zidovudine and Carbovir for Patients With HIV
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Tipranavir capsules|DRUG: Ritonavir capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting the PAM50 Her2-Enriched Phenotype With Enzalutamide in Hormone Receptor-Positive/Her2-Negative Metastatic BC
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects in Adult Subjects With Elevated LDL-C
Status: RECRUITING
Conditions: To Reduce the LDL-C Level in Hypercholesteremia Patients
Interventions: DRUG: RN0191
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Influence of the Antioxidant Treatment in the Oxidant-reduction Potential in Seminal Plasma in Men Whose Partners Will Undergo Through an Egg Donation Cycle
Status: WITHDRAWN
Conditions: Compare the sORP Rate in Sperm Samples, Obtained by the Mioxsys System, Before and After 2.5 Months Antioxidant Men Supplements Treatment (Fertybiotic Man)
Interventions: DIETARY_SUPPLEMENT: Antioxidant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib and Dostarlimab for the Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma|Stage IV Pancreatic Cancer AJCC v8
Interventions: BIOLOGICAL: Dostarlimab|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Standardized Test Protocols to Assess the Impact of Visual Pathologies in Daily Life Activities
Status: UNKNOWN
Conditions: Retinitis Pigmentosa
Interventions: BEHAVIORAL: performance of behavioral locomotion tasks phase 1|BEHAVIORAL: performance of behavioral locomotion tasks phase 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: DMT210 Topical Gel in the Treatment of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: DMT210 Topical Gel|DRUG: Vehicle Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Axillary Versus Subclavian Vein Strategies for Central Venous Catheterization Under Continuous Ultrasound Guidance
Status: COMPLETED
Conditions: Central Venous Catheterization
Interventions: PROCEDURE: Axillary strategy|PROCEDURE: Subclavian strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Angiogenesis and Fibrosis in Aortic Stenosis
Status: COMPLETED
Conditions: Aortic Stenosis|Fibrosis|Neovascularization, Pathologic
Interventions: PROCEDURE: Cardiac MRI scan|RADIATION: CT-PET scan|PROCEDURE: Echocardiogram|RADIATION: CT-coronary angiogram scan|PROCEDURE: Aortic Valve Replacement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Investigate Effects of Amway Bundle Combination of Products on Osteoarthritis & Sarcopenia
Status: COMPLETED
Conditions: Osteoarthritis|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Bundle Group 1 with Nutrilite Lifestyle|DIETARY_SUPPLEMENT: Bundle Group 2 without Nutrilite Lifestyle|DIETARY_SUPPLEMENT: Control Group 1|DIETARY_SUPPLEMENT: Control Group 2 with Nutrilite Lifestyle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Otitis Media (AOM) Therapy Trial in Young Children
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: DRUG: amoxicillin-clavulanate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Secukinumab for NLD (Cosentyx) in Patients With Necrobiosis Lipoidica Diabeticorum (NLD)
Status: TERMINATED
Conditions: Necrobiosis Lipoidica Diabeticorum
Interventions: DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Phosphate Levels in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: 1.25 g PA21 (250 mg iron)|DRUG: 5.0 g PA21 (1,000 mg iron)|DRUG: 7.5 g PA21 (1,500 mg iron)|DRUG: 10.0 g PA21 (2,000 mg iron)|DRUG: 12.5 g PA21 (2,500 mg iron)|DRUG: Sevelamer hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Articaine 4% Versus Mepivacaine 2% for Surgery of Molars Thirds: Clinical Trial.
Status: COMPLETED
Conditions: Pain|Teeth, Impacted
Interventions: DIAGNOSTIC_TEST: Group 1 -Pain monitor|DIAGNOSTIC_TEST: Group 2 -Pain monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Natalizumab in Combination With Glatiramer Acetate (GA) in Patients With Relapsing-Remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Natalizumab|DRUG: Natalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrafiltration (Aquapheresis) in Patients With Leukemia and Severe Fluid Overload
Status: WITHDRAWN
Conditions: Leukemia
Interventions: PROCEDURE: Aquapheresis|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Water Carbonation on Orthostatic Tolerance
Status: RECRUITING
Conditions: Orthostatic Hypotension|Syncope|Vasovagal Syncope
Interventions: OTHER: 500mL carbonated water|OTHER: 500mL still water|OTHER: 50mL still water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Neoadjuvant Study of Tislelizumab and SX-682 for Resectable Pancreas Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Tislelizumab|DRUG: SX-682
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Evaluation of Tiotropium add-on Therapy in Patients With Severe Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: tiotropium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Supporting the Improvement and Management of Prescribing for Urinary Tract Infections (SIMPle)
Status: COMPLETED
Conditions: Uncomplicated Urinary Tract Infection
Interventions: BEHAVIORAL: Improving GP antibiotics prescribing behaviour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Intubation-surfactant-extubation (InSurE) Technique in Preterm Neonates With Respiratory Distress Syndrome
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome of Newborn
Interventions: PROCEDURE: LISA+SNIPPV|PROCEDURE: traditional InSurE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Approach to Improve the Outcome of Social Cognition Training
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Oxytocin|OTHER: Placebo|BEHAVIORAL: Social Cognitive Skills Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Sclerosing Cholangitis Without Cirrhosis
Status: COMPLETED
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: Cilofexor|DRUG: Placebo to match cilofexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Effectiveness of Two Types of Ultrasound Technologies in Women Who Have Had Breast Cancer
Status: RECRUITING
Conditions: Malignant Breast Neoplasm
Interventions: PROCEDURE: Ultrasonography|PROCEDURE: Automated Breast Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Study of Tarceva (Erlotinib) in Combination With Avastin (Bevacizumab) in Patients With Advanced Non-Small Cell Lung Cancer.
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Bevacizumab|DRUG: Standard platinum-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Workshop on Strengths and Competences to Improve Psychological Wellbeing and Quality of Life of Grandparents
Status: RECRUITING
Conditions: Psychological Well-being|Quality of Life|Virtues|Skill, Coping
Interventions: BEHAVIORAL: Psychoeducational Workshop on Personal Strengths and Emotional Competences to Improve the Psychological Wellbeing and Quality of Life of Grandparents Caring for Their Grandchildren
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of ACTR T Cell Product in Combination With Trastuzumab in Subjects With HER2-Positive Advanced Solid Tumor Cancers
Status: TERMINATED
Conditions: Solid Tumor|HER-2 Protein Overexpression
Interventions: BIOLOGICAL: ACTR T Cell Product|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Acceptance and Efficacy Assessment of a Topical Product in Acne Treatment When Compared to a Placebo.
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: ACN cream (YUN)|OTHER: Placebo cream (YUN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Physical Teraphy in the Treatment of Myogenic Temporomandibular Disorders
Status: COMPLETED
Conditions: Temporomandibular Disorder
Interventions: OTHER: control group|OTHER: test group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Susceptibility Biomarkers in Children With Neuroblastoma (Also Known as Neuroblastoma Epidemiology in North America [NENA])
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease
Status: WITHDRAWN
Conditions: Chronic Granulomatous Diseases (CGD) and Liver Lesions
Interventions: DEVICE: Cool-tip RF Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dapagliflozin/Metformin XR vs Monotherapies on Anthropometric Indicators in Obesity
Status: UNKNOWN
Conditions: Obesity
Interventions: DRUG: Dapagliflozin|DRUG: Dapagliflozin plus Metformin XR|DRUG: Metformin XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Ultra-speed Picosecond Laser for Treating Tattoos
Status: COMPLETED
Conditions: Tattoo; Pigmentation
Interventions: DEVICE: Laser Utilisation PicoSecond|DEVICE: Laser Utilisation Nano-second
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CD19-specific T Cell Infusion in Patients With B-Lineage Lymphoid Malignancies
Status: COMPLETED
Conditions: Lymphoma|B-cell Lymphoma
Interventions: PROCEDURE: Leukapheresis|PROCEDURE: Stem Cell Transplant|PROCEDURE: CD19-specific T Cell Infusion|DRUG: IL-2|DRUG: Carmustine|DRUG: Etoposide|DRUG: Cytarabine|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LOTUS Trial: Lumbar Ultrasound in Obstetric Patients With BMI > 40
Status: ENROLLING_BY_INVITATION
Conditions: Obesity, Morbid|Labor Pain
Interventions: DIAGNOSTIC_TEST: Lumbar Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Cannula and Exercise in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DEVICE: High Flow Nasal Cannula Oxygen|DEVICE: The Venturi Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma (MEFO-trial)
Status: COMPLETED
Conditions: Right-sided Colon Cancer|Right-sided Colon Adenoma
Interventions: DRUG: therapeutic endoscopy with metronidazole and fosfomycin disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Dose From Computed Tomography Before and After Implementation of a High Pitch Dual Spiral Technique
Status: COMPLETED
Conditions: Atherosclerosis of Coronary Artery|Cardiovascular Disease|Pulmonary Embolism|Aortic Aneurysm Without Mention of Rupture Nos
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Ritalin on Postural Stability of Old Adults
Status: COMPLETED
Conditions: Postural Imbalance
Interventions: DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Total Knee Arthroplasty Using a Customized-patient Specific Instrument System.
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Arthroplasty, Replacement, Knee
Interventions: DEVICE: Patient specific instrumentation (MRI)|DEVICE: Patient specific instrumentation (CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Tamsulosin and Time to Spontaneous Void After Hysterectomy
Status: COMPLETED
Conditions: Urinary Retention Postoperative
Interventions: DRUG: Tamsulosin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Pleural Carcinosis of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin Administration
Status: RECRUITING
Conditions: Mesothelioma, Malignant|Carcinoma, Non-Small-Cell Lung|Carcinoma Breast Stage IV|Ovarian Cancer|Esophageal Cancer|Gastric Cancer
Interventions: DRUG: Cisplatine Teva®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Doxycycline in the Treatment of Corneal Burn
Status: UNKNOWN
Conditions: Eye Burns
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of FCM vs. Standard of Care in Treating Iron Deficiency Anemia in Heavy Uterine Bleeding and Post Partum Patients
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Ferric Carboxymaltose|DRUG: Standard Medical Care (SMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Probiotic Formulation on Energy Balance in Overweight Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Probiotic formulation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of an Intervention of Fresh Strawberries on Menstrual Pain and Menstrual Distress
Status: COMPLETED
Conditions: Primary Dysmenorrhea|Menstrual Pain|Menstrual Distress \(Dysmenorrhea\)
Interventions: DIETARY_SUPPLEMENT: Strawberry Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerance and Utilization of Agave Inulin in Healthy Adults
Status: COMPLETED
Conditions: Tolerance
Interventions: OTHER: Agave Inulin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Comparing Two Subcutaneous Formulations: Vial and Autoinjector (AI) With Olezarsen, at Two Dose Levels, in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Olezarsen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Autophagy Maintains Vascular Function Through a Novel Glycolysis-linked Pathway Regulating eNOS
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: OTHER: Rhythmic Handgrip Exercise|OTHER: Chronic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of a Novel Protein Supplement on Appetite in Older Adults
Status: COMPLETED
Conditions: Aging|Appetite Loss
Interventions: DIETARY_SUPPLEMENT: Whey Protein Concentrate|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Whey hydrolysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Two Investigational Drugs in Patients With Mixed Hyperlipidemia (0653-036)
Status: COMPLETED
Conditions: Hypercholesterolemia|Hypertriglyceridemia
Interventions: DRUG: MK0653, ezetimibe|DRUG: Comparator: fenofibrate monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Brain Imaging Study With Positron Emission Tomography and the Radiotracer [11C]UCB-J to Estimate How Fast Brivaracetam and Levetiracetam Enter the Brain in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: RADIATION: [11C]UCB-J|DRUG: Brivaracetam|DRUG: Levetiracetam|DRUG: Brivaracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Validation of an Automated Online Language Interpreting Tool - Phase Two.
Status: COMPLETED
Conditions: Mood Disorder|Anxiety Disorder|Substance Use Disorder|Chronic Medical Condition
Interventions: BEHAVIORAL: Active comparator: Human interpreter|BEHAVIORAL: Intervention: Asynchronous Telepsychiatry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: tDCS Plus Virtual Reality for PTSD
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DEVICE: Active stimulation|DEVICE: Sham stimulation|OTHER: Virtual Reality (VR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting-Associated Immune-metabolic Remission of Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Obesity
Interventions: BEHAVIORAL: weight loss by very low energy diet intake which may differ in protein or carbohydrate content
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy
Status: COMPLETED
Conditions: Postoperative Hemorrhage|Breast Neoplasms|Seroma
Interventions: DRUG: Tranexamic Acid|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Longterm Postoperative Analgesia, Intravenous Lidocaine Infusion
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Lidocaine|DRUG: 0.9% Sodium-chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects
Status: COMPLETED
Conditions: Malaria Prophylaxis
Interventions: DRUG: azithromycin (AZ) microsphere|DRUG: test chloroquine (CQ) formulation|DRUG: azithromycin (AZ)|DRUG: chloroquine (CQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Drainage or Not for Laparoscopic Cholecystetomy
Status: UNKNOWN
Conditions: Cholecystitis|Cholecystolithiasis|Polyps Gallbladder|Adenomyosis of Gallbladder
Interventions: PROCEDURE: drainage tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy
Status: COMPLETED
Conditions: Pain|Postoperative Depression
Interventions: DRUG: Ketamine|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Topical Essential Oil Extracted From Zingiber Cassumunar Rokb in Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DRUG: Cream from Zingiber cassumunar Roxb. extract|DRUG: Placebo cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expanding Access to Home-Based Palliative Care
Status: TERMINATED
Conditions: Cancer|Congestive Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Home-based palliative care|OTHER: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diabetes Remote Intervention to improVe Use of Evidence-based Medications
Status: COMPLETED
Conditions: Cardiovascular Diseases|Diabetes
Interventions: DRUG: SGLT2 inhibitor, GLP-1 RA|BEHAVIORAL: Education-First
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Platelet Rich Plasma for the Treatment of Osteochondral Lesions of the Talus
Status: NOT_YET_RECRUITING
Conditions: Osteochondral Lesions of the Talus
Interventions: BIOLOGICAL: platelet rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Butantan|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MINI-AMI: Minimizing Infarct Size With Impella 2.5 Following PCI for Acute Myocardial Infarction
Status: TERMINATED
Conditions: ST-elevation Myocardial Infarction
Interventions: DEVICE: Impella 2.5 support|OTHER: Standard of care (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: Experimental: Primary Cohort|OTHER: Placebo Comparator: Primary Cohort - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pain Management Study
Status: ENROLLING_BY_INVITATION
Conditions: Pain, Postoperative
Interventions: DRUG: Active Comparator: narcotic regimen with TAP block|DRUG: Active Comparator: narcotic regimen with no TAP block|DRUG: non-narcotic regimen with TAP block|DRUG: non-narcotic regimen with no TAP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACVBP Versus ACVBP Plus Rituximab in Low Risk Localized Diffuse Large B-cell Lymphoma
Status: TERMINATED
Conditions: Diffuse Large Cell Lymphoma
Interventions: DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Postpartum Preeclampsia|Hypertension in Pregnancy
Interventions: DRUG: Labetalol Oral Tablet|DRUG: NIFEdipine ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness, Tolerability and Safety of Rasagiline in Early Parkinson's Disease Patients Not Treated With Levodopa
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Rasagiline Mesylate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Effectiveness of the Freedom Bed as Compared to Alternating Pressure Mattress in Treatment of Pressure Injuries in Persons With Limited Mobility Due to Traumatic Brain Injury and /or Spinal Cord Injury
Status: UNKNOWN
Conditions: Pressure Injury
Interventions: DEVICE: Freedom Bed|DEVICE: Group II Low Air Loss/Alternating Pressure Mattress
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reproducibility of Intratumor Distribution of 18F-EF5 in Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: 18F-EF5|PROCEDURE: Pretreatment PET/CT-scan (performed two times)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Newly Diagnosed Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Proof-of-Concept Study of Ixekizumab in the Treatment of Pyoderma Gangrenosum
Status: COMPLETED
Conditions: Pyoderma Gangrenosum
Interventions: BIOLOGICAL: Ixekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Myristyl Nicotinate Cream on the Skin of Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Topical Myristyl Nicotinate Cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
Status: RECRUITING
Conditions: Bladder Cancer|Bladder Urothelial Carcinoma
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramucirumab and Trifluridine/Tipiracil or Paclitaxel for the Treatment of Patients With Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer
Status: RECRUITING
Conditions: Clinical Stage III Gastric Cancer AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IV Gastric Cancer AJCC v8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVA Gastric Cancer AJCC v8|Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IVB Gastric Cancer AJCC v8|Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Locally Advanced Unresectable Gastric Adenocarcinoma|Locally Advanced Unresectable Gastroesophageal Junction Adenocarcinoma|Metastatic Gastric Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Pathologic Stage III Gastric Cancer AJCC v8|Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIA Gastric Cancer AJCC v8|Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIB Gastric Cancer AJCC v8|Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IIIC Gastric Cancer AJCC v8|Pathologic Stage IV Gastric Cancer AJCC v8|Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage III Gastric Cancer AJCC v8|Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8|Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8|Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
Interventions: DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Ramucirumab|DRUG: Trifluridine and Tipiracil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Performance of the NESS L300 Plus System
Status: COMPLETED
Conditions: Foot Drop|Thigh Muscles Weakness (Hamstrings or Quadriceps)|Upper Motor Neuron Injury or Disease
Interventions: DEVICE: NESS L300 Plus System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TCRαβ+/CD19+ Depleted Allogeneic Hematopoietic Stem Cell Transplantation for Malignant and Non-malignant Disorders
Status: TERMINATED
Conditions: Allogeneic Hematopoietic Cell Transplantation
Interventions: DRUG: TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fish Oil, Metformin and Heart Health in PCOS
Status: NOT_YET_RECRUITING
Conditions: PCOS|Cardiovascular Disease|Atherosclerotic Cardiovascular Disease|Atherosclerotic Plaque|Cardiac Hypertrophy
Interventions: DIETARY_SUPPLEMENT: Fish oil|DRUG: Metformin|COMBINATION_PRODUCT: Fish Oil and Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fibre Supplements on Gestational Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DIETARY_SUPPLEMENT: Guar gum|DIETARY_SUPPLEMENT: Cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Natural History of HPV Infection in Men: The HIM Study
Status: COMPLETED
Conditions: Human Papillomavirus
Interventions: OTHER: Cohort: 3000 men examined every 6 months for 4 years.|OTHER: Pilot study: 150 men examined every 6 months for 4 years.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Daylight-PDT With MAL for AK and Photodamaged Skin
Status: COMPLETED
Conditions: Actinic Keratoses|Photodamaged Skin
Interventions: DRUG: Daylight photodynamic therapy using Methylaminolevulinate (MAL)|PROCEDURE: Cryosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Neridronate to Treat Painful Osteoarthritis of the Knee With Bone Marrow Lesions.
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Neridronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Artery Repair With Covered Stents
Status: COMPLETED
Conditions: Pulmonary Stenosis|Pulmonary Regurgitation|Tetralogy of Fallot
Interventions: DEVICE: Repair of RV-PA Conduit Disruption
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging|Sarcopenia
Interventions: OTHER: High intensity interval training (HIIT)|OTHER: Resistance based training (RET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes
Status: COMPLETED
Conditions: Tobacco Dependence
Interventions: DRUG: Very low nicotine content cigarettes|DRUG: Normal nicotine content cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Activity of BAY 43-9006 in Patients With Recurrent and/or Metastatic Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: BAY 43-9006
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Men With Mild To Moderate Erectile Dysfunction To Evaluate The Efficacy Of Viagra 8 Hours Post-Dose
Status: COMPLETED
Conditions: Impotence
Interventions: DRUG: Viagra (Sildenafil Citrate) 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Digital Vital Sign Monitoring to Decrease Sleep Interruption and Enhance Recovery in Phase II of the PROmoting Sleep, Patient Engagement and Recovery (PROSPER) Project
Status: COMPLETED
Conditions: Sleep
Interventions: DEVICE: ViSi Mobile device|DRUG: Sleep enhancement intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Pharmacodynamics, and Efficacy of Migalastat in Pediatric Subjects (Aged >12 Years) With Fabry Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Fabry Disease
Interventions: DRUG: migalastat HCl 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Family Caregiver Online Survey (Dementia and Swallowing Difficulties)
Status: RECRUITING
Conditions: Dementia|Dysphagia|Dementia Alzheimers|Dementia, Vascular|Dementia, Mixed|Dementia With Lewy Bodies|Dementia Frontal|Dementia, Mild|Dementia Moderate|Dementia Severe|Parkinson Disease Dementia|Dementia Frontotemporal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Childhood B Acute Lymphoblastic Leukemia|Childhood T Acute Lymphoblastic Leukemia|Cognitive Side Effects of Cancer Therapy|Long-Term Effects Secondary to Cancer Therapy in Children|Neurotoxicity Syndrome|Psychological Impact of Cancer|Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: PROCEDURE: Cognitive Assessment|PROCEDURE: Diffusion Tensor Imaging|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|PROCEDURE: Psychosocial Assessment and Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sexual Functioning Study With Antidepressants
Status: COMPLETED
Conditions: Depressive Disorder, Major|Major Depressive Disorder (MDD)
Interventions: DRUG: Bupropion Hydrochloride Extended-release|DRUG: Extended-release Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for Cocaine Addiction
Status: UNKNOWN
Conditions: Cocaine Dependence|Substance Use Disorders|Chemical Addiction|Mental Disorder|Cocaine-Related Disorders|Drug Dependence
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of an Online Problem-solving Intervention for Aggression
Status: COMPLETED
Conditions: Aggression
Interventions: BEHAVIORAL: Problem-solving
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Research and Evaluation of Antipsychotic Treatment in Community Behavioral Health Organizations
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder
Interventions: DRUG: Risperidone long acting injectable - New Starts|DRUG: Risperidone long acting injectable - Continuous Users|DRUG: Paliperidone Palmitate -New and Continuous Users|DRUG: Other Antipsychotics - New Starts
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Of 6 CP-690,550 Doses Vs.Placebo, Each Combined With Methotrexate, For The Treatment Of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|DRUG: CP-690,550|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EN3285 for the Prevention or Delay of Oral Mucositis in Patients With Head and Neck Cancer
Status: TERMINATED
Conditions: Oral Mucositis|Head and Neck Cancer
Interventions: DRUG: EN3285|DRUG: Placebo|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vestibular and Multisensory Influence on Bodily and Spatial Representations
Status: UNKNOWN
Conditions: Vestibular Disorders
Interventions: OTHER: electromyography|OTHER: electroencephalography|OTHER: approaches from psychophysics
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial of Equine F (ab')2 Antivenom for Treatment of Scorpion Envenomation in Morocco
Status: COMPLETED
Conditions: Poisoning by Scorpion Sting
Interventions: BIOLOGICAL: Equine F(ab')2 antivenom|OTHER: Intensive care support plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of In-bag Morcellation
Status: COMPLETED
Conditions: Uterine Myomatosis|Laparoscopy|Hysterectomy, Vaginal
Interventions: DEVICE: laparoscopic myomectomy or hysterectomy with More-cell-Safe AMI bag morcellation|PROCEDURE: laparoscopic myomectomy or hysterectomy without any morcellation bag
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplant With Clofarabine, Ara-C and TBI for AML and ALL
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Acute Myelogenous Leukemia
Interventions: DRUG: Clofarabine|DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is Cryosurgery or Curettage More Effective at Treating Seborrheic Keratoses?
Status: COMPLETED
Conditions: Seborrheic Keratosis
Interventions: PROCEDURE: cryosurgery|PROCEDURE: Curettage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?
Status: COMPLETED
Conditions: Methicillin-resistant Staphylococcus Aureus Septicemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Trial of External Beam Radiotherapy Versus Cryoablation in Patients With Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: Cryoablation and External Beam Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Study to Assess the Safety and Effectiveness of AA4500 in Combination With the ErecAid® Esteem® Manual Vacuum Therapy System in Treating Men With Peyronie's Disease
Status: COMPLETED
Conditions: Peyronie's Disease
Interventions: BIOLOGICAL: AA4500|DEVICE: ErecAid® Esteem® Manual Vacuum Therapy System|PROCEDURE: Investigator Modeling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CHANGE Neo™ TA Registry With ACURATE Neo™ Aortic Bioprosthesis and ACURATE Neo™ TA Transapical Delivery System
Status: TERMINATED
Conditions: Aortic Stenosis
Interventions: DEVICE: ACURATE neo™ Aortic Bioprosthesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Enhancing Uptake of Preconception Care Services in Family Practice Clinics Using a Patient Centered Screening Tool
Status: RECRUITING
Conditions: Women|Reproductive Age
Interventions: OTHER: Preconception Screening Questionnaire with Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea
Status: COMPLETED
Conditions: Corneal Newvessels
Interventions: DRUG: bevacizumab|DRUG: NaCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab as Salvage Therapy for the Treatment of Multiple Myeloma in Patients Progressing on CAR-T Cell Therapy
Status: WITHDRAWN
Conditions: Plasma Cell Myeloma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colonic Motor Patterns in Healthy Volunteers
Status: COMPLETED
Conditions: Opioid-Induced Constipation
Interventions: DRUG: Naloxegol|DRUG: codeine phosphate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT