pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Repurposing Dexmedetomidine as an Orally Administered Sleep Therapeutic
Status: COMPLETED
Conditions: Sleep|Insomnia
Interventions: DRUG: Dexmedetomidine|OTHER: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Vertebral Manipulation and Pain Education in Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Spinal Manipulation|OTHER: Pain Education|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Additive Value of Pyridostigmine to Silodosin in Acute Urinary Retention
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: silodosin 8 mg capsule and the pyridostigmine bromide 60 mg tablet|DRUG: silodosin 8 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Role of At-home Semi-quantitative Pregnancy Tests for Follow-up to Menstrual Regulation Service
Status: COMPLETED
Conditions: Menstrual Regulation
Interventions: DEVICE: Semi-quantitative pregnancy test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vital Pulp Therapy in Carious Teeth With Hypomineralization
Status: COMPLETED
Conditions: Dental Caries Extending to Pulp|Molar Incisor Hypomineralization
Interventions: PROCEDURE: IPT (Indirect pulp treatment)|PROCEDURE: Cvek/partial pulpotomy|PROCEDURE: Cervical pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registry Platform Ovarian and Endometrial Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Endometrial Cancer|Ovary Neoplasm|Endometrial Neoplasms|Carcinoma, Ovarian|Carcinoma|Neoplasm, Ovarian
Interventions: OTHER: Physician's choice according to patient's needs.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IV Ibuprofen for Post-Electroconvulsive Therapy Myalgia
Status: TERMINATED
Conditions: Depression, Myalgia
Interventions: DRUG: Placebo infusion|DRUG: ibuprofen intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Evaluate an Intervention Based on Mindfulness to Reduce Anxiety in Breast Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety|Breast Cancer|Survivorship
Interventions: OTHER: Mindfulness-based stress reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1: Randomized Evaluation of a System to Deliver Mobile Cognitive Behavioral Therapy
Status: UNKNOWN
Conditions: Pain, Postoperative|Analgesics, Opioid
Interventions: DEVICE: InCaveo's EOA system with integrated mobile CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of the Alena App as a Treatment for Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder (Social Phobia)|Social Anxiety|Social Anxiety Disorder
Interventions: OTHER: "Alena" mobile application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic Syndrome
Status: TERMINATED
Conditions: Hypertension With Metabolic Syndrome
Interventions: DRUG: Amlodipine|DRUG: Aliskiren|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Oxymetry and Neuronal Markers in Newborns and Infants Undergoing Surgery
Status: COMPLETED
Conditions: Peri-operative Injury|Newborn, Infant, Disease
Interventions: PROCEDURE: Cerebral near infrared spectroscopy|OTHER: S-100B protein in serum|OTHER: NSE protein in serum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: ARV-471 in Combination With Everolimus for the Treatment of Advanced or Metastatic ER+, HER2- Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: ARV-471 in combination with Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft
Status: ENROLLING_BY_INVITATION
Conditions: Infective Endocarditis|Heart Failure
Interventions: PROCEDURE: Cryopreserved Aortic Homograft|PROCEDURE: Stented/Non stented xenograft|PROCEDURE: Mechanical prostheses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Receiving Modified Chemotherapy Followed With Radical Resection After Neoadjuvant Chemotherapy
Status: UNKNOWN
Conditions: Locally Advanced Gastric Cancer
Interventions: DRUG: Paclitaxel/DDP|DRUG: XELOX/SOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Vibration-based Wearable Upper Limb Rehabilitation Device
Status: TERMINATED
Conditions: Stroke
Interventions: DEVICE: Vibration Massage Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Treatment of Stage IV Breast Cancer Through Real-Time Disease Monitoring
Status: SUSPENDED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ketamine in Chronic Kid's (KiCK) Pain
Status: TERMINATED
Conditions: Chronic Pain
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Syringe Free" Long-Axis In-Plane vs. Short-Axis Out-of-Plane Approach for Central Venous Catheter Placement
Status: COMPLETED
Conditions: Catheter Complications|Critical Illness
Interventions: DEVICE: Long-axis syringe free in-plane|DEVICE: Short-axis out-of-plane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clonal Hematopoiesis in Giant Cell Arteritis
Status: NOT_YET_RECRUITING
Conditions: Giant Cell Arteritis|Temporal Arteritis|Clonal Hematopoiesis of Indeterminate Potential|Horton Disease|Systemic Vasculitis Primary
Interventions: DIAGNOSTIC_TEST: Temporal arterial biopsy|DIAGNOSTIC_TEST: Whole exome sequencing|DIAGNOSTIC_TEST: Single cell transcriptomics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Methylphenidate on Non-motor Symptoms and Postural Control in Parkinson's Disease.
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DRUG: Methylphenidate|DRUG: Methylphenidate|DRUG: Placebo 10|DRUG: Placebo 20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide in Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Inhaled Nitric Oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-marketing Surveillance Study to Assess the Safety of Cervarix (GlaxoSmithKline [GSK] Biologicals' Human Papillomavirus [HPV] -16/18 Vaccine), When Administered According to the Approved Prescribing Information (PI) in Korea
Status: COMPLETED
Conditions: Neoplasms, Rectal
Interventions: OTHER: Safety data collection (following routine vaccination) by a continuous surveillance method.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dileucine and Resistance Training Adaptations
Status: COMPLETED
Conditions: Hypertrophy|Strength Training Adaptations|Weight-Bearing Strengthening Program
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Leucine|DIETARY_SUPPLEMENT: Dileucine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1 Open-Label Study of E7974 Administered on Days 1 and 15 of a 28-Day Cycle in Patients With Solid Malignancies
Status: COMPLETED
Conditions: Cancer, Malignant Tumors
Interventions: DRUG: E7974
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Prevention
Interventions: BEHAVIORAL: Narrative Exposure Therapy (NET)|BEHAVIORAL: Motivational Interviewing w/Skills Training (MIST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate Safety and Efficacy of ABT-335 in Combination With Atorvastatin in Subjects With Multiple Abnormal Lipid Levels in the Blood
Status: COMPLETED
Conditions: Mixed Dyslipidemia|Coronary Heart Disease|Dyslipidemia
Interventions: DRUG: ABT-335|DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Active AMD Study to Improve Function in Veterans
Status: RECRUITING
Conditions: Age Related Macular Degeneration (AMD)
Interventions: BEHAVIORAL: SPIN|BEHAVIORAL: Non-aerobic, stretching/balance intervention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sympathetic Nervous System Inhibition for the Treatment of Diabetic Kidney Disease
Status: COMPLETED
Conditions: Diabetic Nephropathies
Interventions: DRUG: Moxonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Motor Training After Perinatal Stroke to Enhance Walking
Status: COMPLETED
Conditions: Perinatal Stroke
Interventions: BEHAVIORAL: Early leg training|BEHAVIORAL: Delayed leg training|BEHAVIORAL: Parent leg training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia)
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukaemia - Category
Interventions: DRUG: Ciprofloxacin|DRUG: Antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The ENDEAVOR IV Clinical Trial: A Trial of a Coronary Stent System in Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Coronary Artery Stenting|DEVICE: Coronary Artery Stenting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of JKB-122 in Patients With NASH and Fibrosis
Status: UNKNOWN
Conditions: Nonalcoholic Steatohepatitis (NASH) With Fibrosis
Interventions: DRUG: Placebo|DRUG: Dose 1 JKB-122|DRUG: Dose 2 JKB-122
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Magnesium Use in Reversal of Neuromuscular Block With Sugammadex
Status: RECRUITING
Conditions: Magnesium Sulfate|Pregnancy; Pre-Eclampsia|Neuromuscular Blockade
Interventions: DRUG: pregnant women taking magnesium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Disgust Reduction Through Evaluative Conditioning (DREC) and tDCS in Contamination-Based OCD
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: OTHER: Active EC training|OTHER: Sham EC training|OTHER: Active tDCS|OTHER: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Versus Conservative Treatment of Degenerative Meniscal Tear in Middle Aged Patients in Regard to Pain & Knee Function
Status: COMPLETED
Conditions: Knee Pain Chronic
Interventions: PROCEDURE: Arthroscopic menisctomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Anti Diabetic Agents in the Hospital
Status: RECRUITING
Conditions: Diabetes Mellitus
Interventions: DRUG: Oral Anti-diabetes Drugs alone|DRUG: Basal bolus insulin|DRUG: Supplemental insulin|DEVICE: Continuous glucose monitoring (CGM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Omeprazole|DRUG: Losartan|DRUG: Dextromethorphan|DRUG: Cocktail|DRUG: Midazolam|DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary Disease
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Solithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Phase I Study in Order to Define Lanifibranor (IVA337) Supra-thjerapeutic Dose
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Moxifloxacin|DRUG: Placebo|DRUG: Lanifibranor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitor Application After Hospital Discharge for the Improvement of Outcomes in Patients With Poorly Controlled Type 2 Diabetes and Active Cancer
Status: COMPLETED
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm|Type 2 Diabetes Mellitus
Interventions: OTHER: Educational Intervention|OTHER: Medical Device Usage and Evaluation|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial Comparing Treatment Strategies in Triangular Fibrocartilage Complex Ruptures
Status: RECRUITING
Conditions: Triangular Fibrocartilage Complex Injury
Interventions: PROCEDURE: Arthroscopic Debridement|PROCEDURE: Placebo surgery|PROCEDURE: Arthroscopic or Open Repair|PROCEDURE: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Circulating Biomarkers in the Development of Type 1 Diabetes
Status: RECRUITING
Conditions: Diabetes
Interventions: OTHER: One-time blood (up to 100 ml) will be drawn and the amount of blood drawn is based on weight. Saliva and urine will be collected during the blood draw visit.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: nalmefene hydrochloride 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis
Status: TERMINATED
Conditions: Progressive Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting
Interventions: OTHER: Neuropsychological assessment|OTHER: Neurologic consultation|OTHER: MRIs (with vasoreactivity testing)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bortezomib and Gemcitabine in Treating Patients With Relapsed B-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: bortezomib|DRUG: gemcitabine hydrochloride|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Foot Reflexology to Reduce Pain and Anxiety Before Chest Tube Removal
Status: COMPLETED
Conditions: Chest Tube Removal|Heart; Surgery, Heart, Functional Disturbance as Result|Pain|Anxiety
Interventions: OTHER: Reflexology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Myo-inositol as Pretreatment in Hyperandrogenic PCOS Patients
Status: UNKNOWN
Conditions: PCOS|Female Infertility
Interventions: DRUG: Myo-inositol|DRUG: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: oral erlotinib and pulsed doses of oral AT-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Efficacy and Safety of OSU6162 in the Treatment of Residual Symptoms After Stroke
Status: COMPLETED
Conditions: Stroke Sequelae
Interventions: DRUG: OSU 6162|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CYP2C19 Genotype-Specific Dosing Plus TDM on Reaching Therapeutic Voriconazole Blood Levels
Status: COMPLETED
Conditions: Aspergillosis Invasive|Fungal Infection
Interventions: GENETIC: Voriconazole genotype-specific dosing|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Energy Expenditure and Substrate Oxidation in a Whole Room Calorimeter
Status: TERMINATED
Conditions: Overweight|Obesity|Body Weight
Interventions: OTHER: Low fat meal|OTHER: Moderate fat meal|OTHER: High fat meal|OTHER: High fat liquid meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Endotoxemia
Interventions: DEVICE: TORAYMYXIN PMX-20R (PMX cartridge)|OTHER: Standard medical care for septic shock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Chemoprevention of Skin Cancer Biomarkers
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-melanoma Skin Cancer
Interventions: DRUG: topical diclofenac daily|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I/II Study of Recombinant Interleukin-4 in AIDS and Kaposi's Sarcoma
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections
Interventions: DRUG: Interleukin-4
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Bridging Study of the SYN023 on Healthy Adult Subjects
Status: COMPLETED
Conditions: Communicable Disease Transmission|Zoonotic Disease|Rabies Human|Vaccine Reaction|Immunisation Reaction
Interventions: BIOLOGICAL: recombinant anti-rabies human monoclonal antibody injection (SYN023)|BIOLOGICAL: Rabies Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avonex®: Safety, Blood Levels and Effects
Status: COMPLETED
Conditions: Multiple Sclerosis (MS)
Interventions: DRUG: Interferon beta 1a|DRUG: (IM) AVONEX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Investigate the Impact of a Nutritional Supplement on Bone Turnover Markers in Indian Healthy Premenopausal Women (25- 45 Years) After 6 Months of Intervention
Status: COMPLETED
Conditions: Growth and Development
Interventions: DIETARY_SUPPLEMENT: Fortified Beverage Powder|DIETARY_SUPPLEMENT: Non fortified beverage Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Spinal Magnetic Stimulation in Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DEVICE: magnetic stimulation|DEVICE: Magnetic Stimulation with tilted coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Whitening Toothpaste on Tooth Color Associated With Bleaching Process
Status: COMPLETED
Conditions: Tooth Discoloration
Interventions: COMBINATION_PRODUCT: in-office bleaching with the conventional whitening dentifrice|COMBINATION_PRODUCT: in-office bleaching with the whitening dentifrice containing blue covarine|COMBINATION_PRODUCT: in-office bleaching with the regular dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage
Status: ACTIVE_NOT_RECRUITING
Conditions: Subarachnoid Hemorrhage|Delayed Cerebral Ischemia|Cerebral Vasospasm|CT Perfusion
Interventions: RADIATION: CT Perfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Change in Brain Perfusion During Induction of General Anesthesia
Status: RECRUITING
Conditions: Interventional Radiology|Orthopedic Surgery
Interventions: OTHER: Continuous monitoring of arterial blood pressure|OTHER: Transcranial Doppler|OTHER: Bispectral Index (BIS)|OTHER: Near-infrared spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of realSKIN® to Provide Complete Wound Closure of Burn Wounds as an Alternative to Autografting
Status: RECRUITING
Conditions: Burns Degree Third|Burn (Disorder)|Burn Degree Second|Thermal Burn|Wound Heal
Interventions: DRUG: Skin Xenotransplant|PROCEDURE: Autograft(ing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining the Effectiveness of the Pain and Disability Drivers Management Model on the Management of Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: The Low Back Pain and Disability Drivers Management model|OTHER: Low back pain clinical practice guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Galantamine in the Treatment of Post-Traumatic Headache
Status: UNKNOWN
Conditions: Post-Traumatic Headache|Head Trauma,Closed|Retention Disorders,Cognitive
Interventions: DRUG: Galantamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noise-Induced Hearing Loss-Acute Exposure Treatment
Status: TERMINATED
Conditions: Hearing Loss, Noise-Induced
Interventions: DRUG: Zonisamide 100Mg Cap|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Two Atteris Antimicrobial Products on Chronic Wound Healing.
Status: TERMINATED
Conditions: Chronic Wounds
Interventions: DEVICE: Atteris Antimicrobial Skin and Wound Cleanser|DEVICE: Atteris Antimicrobial Barrier Film Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Theta burst stimulation (TBS)|BEHAVIORAL: Robot-assisted training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prebiotic in Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: Fructooligosaccharide|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Molecular and Imaging Studies of Cardiovascular Health and Disease
Status: RECRUITING
Conditions: Healthy|Dilated Cardiomyopathy|Hypertrophic Cardiomyopathy|Ischemic Heart Disease
Interventions: OTHER: Cardiovascular Magnetic Resonance|OTHER: Fatmass measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Uterine Contractions and Mode of Progesterone in Frozen Embryo Transfer (FET) Cycles: Randomized Clinical Trial
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Progesterone in oil|DRUG: vaginal progesterone suppositories
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep Among Cancer Patients: Comparison Between Physical Activity and Self-administered Cognitive-behavioral Therapy (CBT)
Status: COMPLETED
Conditions: Cancer|Insomnia
Interventions: BEHAVIORAL: Physical exercise|BEHAVIORAL: Cognitive-behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Gastric Emptying by SHR20004 in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Acetaminophen/SHR20004|DRUG: Acetaminophen/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Different Approaches in the Fascia Iliaca Compartment Block in Femoral Fracture Surgery
Status: COMPLETED
Conditions: Femoral Fractures|Postoperative Pain
Interventions: PROCEDURE: Suprainguinal Performed FICB|PROCEDURE: Infrainguinal Performed FICB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases
Status: COMPLETED
Conditions: Metastatic Malignant Neoplasm in the Brain|Metastatic Melanoma|Mucosal Melanoma|Ocular Melanoma|Stage IV Non-Small Cell Lung Cancer|Stage IV Skin Melanoma|Melanoma of Unknown Primary
Interventions: BIOLOGICAL: Pembrolizumab|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Ixazomib in Autologous Stem Cell Transplant in Relapsed Myeloma - Myeloma XII (ACCoRd)
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib, thalidomide, & dexamethasone (ITD) re-induction|DRUG: Conventional autologous stem cell transplant (ASCT-con)|DRUG: Augmented autologous stem cell transplant (ASCT-aug)|DRUG: ITD consolidation and ixazomib maintenance vs. No further therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Safety and Pharmacokinetics Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Infants and Children With AIDS or Symptomatic HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivermectin and Balstilimab for the Treatment of Metastatic Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma
Interventions: DRUG: Ivermectin|DRUG: Balstilmab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Combined With Pyrotinib for Chemotherapy Failure HER2 Insertion Mutation Advanced NSCLC
Status: RECRUITING
Conditions: HER2 Insertion Mutation Positive Advanced NSCLC
Interventions: DRUG: PD-1 Combined With Pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cranberry Capsules on Urinary Infection Rates in Spinal Cord Injured Patients During Post Acute Rehabilitation
Status: TERMINATED
Conditions: Spinal Cord Injury|Urinary Tract Infection|Rehabilitation
Interventions: DIETARY_SUPPLEMENT: Cranberry capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Five Anthelmintic Regimes Against Trichuris Trichiura Infections in Schoolchildren in Jimma, Ethiopia
Status: COMPLETED
Conditions: Infection by Trichuris Trichiura
Interventions: DRUG: Albendazole, 2 x 400mg|DRUG: Albendazole 400mg|DRUG: Mebendazole 500mg|DRUG: Mebendazole 2 x 500mg|DRUG: Pyrantel-oxantel + mebendazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PCV7 in the Prevention of Nasopharyngeal Carriage of Vaccine Serotype (VT) Streptococcus Pneumoniae
Status: COMPLETED
Conditions: Streptococcal Pneumonia|Nasopharyngeal Diseases|Vaccination Adverse Event
Interventions: BIOLOGICAL: PCV7 (Pneumococcal 7-Valent Conjugate Vaccine)|BIOLOGICAL: Hib Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Assess the Anti-anginal Safety and Efficacy of Ivabradine in Subjects With Stable，Symptomatic Chronic Angina
Status: UNKNOWN
Conditions: Angina Pectoris
Interventions: DRUG: Ivabradine|DRUG: Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Continuous Blood Pressure Monitoring in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Propranolol|DRUG: Pseudoephedrine|DEVICE: ABPM and Wearable Novel Devices|OTHER: No Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Constipation: Systematic Nursing Interventions to Reduce Postoperative Constipation After Thoracic Surgery
Status: COMPLETED
Conditions: Postoperative Constipation
Interventions: PROCEDURE: Degree of constipation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trans-catheter Arterial Embolization Combined With p53 Gene Therapy for Treatment of Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Advanced Hepatocellular Carcinoma (HCC)
Interventions: DRUG: TAE plus P53 gene|OTHER: TAE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-based Cognitive Behavioral Therapy for Chronic Tic Disorder and Tourette's Disorder: a Feasibility Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Tic Disorder|Tourette Syndrome
Interventions: BEHAVIORAL: Internet-delivered Cognitive Behavior Therapy for Chronic Tic Dosorder/Tourette Disorder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Needling Effectiveness and Post-punction Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Dry needling|PROCEDURE: Transcutaneous Nerve Stimulation.|PROCEDURE: Placebo needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Determination of the Effective Volume of 0.125% Bupivacaine-fentanyl 5mcg/mL in Labour Epidurals
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Bupivacaine-fentanyl|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ICG-PDT, Periimplantitis, Diabetes Mellitus
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: BIOLOGICAL: ICG-PDT|DEVICE: peri-implant mechanical debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Lung Diseases
Interventions: DRUG: Mythylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI
Status: COMPLETED
Conditions: Spinal Cord Injury|Sleep Disordered Breathing
Interventions: DRUG: Buspirone|DRUG: Trazodone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Montelukast in Seasonal Allergic Rhinitis: Fall 2001 Study (0476-240)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: montelukast sodium|DRUG: Comparator: loratadine|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Mobilization and Manipulation of the Thoracic Spine in Patients With Mechanical Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: spine mobilizations|PROCEDURE: spine manipulations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Safety Extension Study of DR-OXY-301
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Oxybutinyn Vaginal Ring 4mg|DRUG: Oxybutinyn Vaginal Ring 6mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Formulations of Propafenone to Treat Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: (R)-propafenone|DRUG: (S)-Propafenone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tolebrutinib (SAR442168) Tablets in Adult Participants With Generalized Myasthenia Gravis
Status: TERMINATED
Conditions: Myasthenia Gravis
Interventions: DRUG: Tolebrutininb|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ensuring Communication in Hospice by Oncology Study (ECHO)
Status: COMPLETED
Conditions: Ovarian Cancer|Cervical Cancer|Uterine Cancer|Head and Neck Cancer|Sarcoma|Melanoma
Interventions: BEHAVIORAL: communication with oncology team
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Recurrent Multiple Myeloma|Refractory Multiple Myeloma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea
Status: COMPLETED
Conditions: Asthma|Sleep Apnea
Interventions: DEVICE: CPAP machine as a result of sleep study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Financial Coaching and Smoking Cessation Coaching
Status: RECRUITING
Conditions: Smoking
Interventions: OTHER: Financial counseling|DRUG: Nicotine Replacement Therapy Agent - Patches|DRUG: Nicotine Replacement Therapy Agent - Lozenges|DRUG: Nicotine Replacement Therapy Agent - Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men
Status: COMPLETED
Conditions: Human Immunodeficiency Virus|Acquired Immunodeficiency Syndrome|HIV Infections|Sexually Transmitted Diseases, Viral|Retroviridae Infections|Virus Diseases|Virus-HIV|RNA Virus Infections
Interventions: BEHAVIORAL: Provision of multiple self-tests|OTHER: Small monetary incentives|BEHAVIORAL: Use of SMS/text reminders to motivate adherence to ART or PrEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Approach of Biliary Drainage in Hepatolithiasis Patients With Sphincter of Oddi Laxity
Status: NOT_YET_RECRUITING
Conditions: Sphincter of Oddi Laxity
Interventions: PROCEDURE: Roux-en-Y Hepaticojejunostomy|PROCEDURE: T-tube drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Safety and Tolerability of CBL-514 Injection on Convexity or Fullness of Abdominal Subcutaneous Fat in Healthy Volunteers
Status: COMPLETED
Conditions: Subcutaneous Fat
Interventions: DRUG: CBL-514, placebo|DRUG: CBL-514, placebo|DRUG: CBL-514
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Irinotecan in Recurrent or Metastatic Esophageal and Gastroesophageal (GE) Junction Carcinoma
Status: TERMINATED
Conditions: Esophageal Cancer|Gastroesophageal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic Control, Safety and Tolerability of TC-6987 Monotherapy in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: TC-6987|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)
Status: ENROLLING_BY_INVITATION
Conditions: Cleft Lip|Cleft Palate|Cleft Lip and Palate
Interventions: PROCEDURE: cleft lip repair|PROCEDURE: cleft palate repair|PROCEDURE: oronasal fistula repair|PROCEDURE: pharyngoplasty|PROCEDURE: gingivoperiosteoplasty|PROCEDURE: LeFort-1 maxillary repositioning|PROCEDURE: rhinoplasty|PROCEDURE: myringotomy and tympanostomy tube placement|OTHER: speech therapy|PROCEDURE: orthodontia|PROCEDURE: presurgical orthopedics|DEVICE: sound amplification for hearing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of Myofascial Chain Release Techniques in Patients With Patellofemoral Pain Syndrome.
Status: UNKNOWN
Conditions: Patellofemoral Pain Syndrome
Interventions: OTHER: Myofascial Chain Release Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Efficacy of Alefacept in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Alefacept|DRUG: tacrolimus|DRUG: basiliximab|DRUG: mycophenolate mofetil|DRUG: Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tracheal Tube Cuff Shape and Pressure
Status: COMPLETED
Conditions: Intubation, Intratracheal|Pain, Postoperative|Dysphonia
Interventions: DEVICE: Different tracheal tube cuff design
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rate of Termination of Premixed Parenteral Nutrition (PN) in Surgical Patients Secondary to High Serum Electrolytes
Status: COMPLETED
Conditions: Hyperphosphatemia|Hyperkalemia|Hypermagnesemia|Hypercalcemia
Interventions: COMBINATION_PRODUCT: Parenteral Nutrition (PN) Premixed Olimel N9E
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Activity Monitoring During Fractionated Radiotherapy in Patients With Head and Neck, Lung, or Gastrointestinal Cancer
Status: COMPLETED
Conditions: Digestive System Carcinoma|Head and Neck Carcinoma|Lung Carcinoma
Interventions: DEVICE: Monitoring Device|OTHER: Quality-of-Life Assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dietary Sodium Intake in Acute Heart Failure
Status: COMPLETED
Conditions: Heart Failure; With Decompensation|Heart Failure，Congestive
Interventions: OTHER: Low sodium diet|OTHER: Normal sodium diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial Comparing N of 1 Trials to Standard Practice to Improve Adherence to Statins in Patients With Diabetes
Status: TERMINATED
Conditions: Diabetes|Cardiovascular Disease|Hyperlipidemia
Interventions: BEHAVIORAL: N of 1 Trials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Body Composition Change for Risk Prediction and Nutritional Guide in Treating Patients With Sepsis
Status: COMPLETED
Conditions: Sepsis
Interventions: DIETARY_SUPPLEMENT: Nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Infantile Colic: Study of the Efficacy of Lactobacillus GG (ATCC 53103) Plus Chamomile in Breastfeeding Infants
Status: TERMINATED
Conditions: Infantile Colic
Interventions: DIETARY_SUPPLEMENT: chamomile/probiotic arm|DIETARY_SUPPLEMENT: Placebo of chamomile/probiotic arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: VCare Versus SecuFix Uterine Manipulator for Total Laparoscopic Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Operative Time|Length of Hospital Stay|Perioperative Complications
Interventions: DEVICE: SecuFix UM|DEVICE: VCare UM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Clinical Trial to Evaluate Pharmacokinetic Interaction of ATB-1011 and ATB-1012 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Adult Volunteers
Interventions: DRUG: Olmesartan|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT