pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Efficacy of XOMA 052 in Subjects With Type 2 Diabetes Mellitus on Stable Metformin Monotherapy
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: XOMA 052|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Intraocular Caliper-assisted Capsulotomy for Age-related Cataract
Status: UNKNOWN
Conditions: Cataract Extraction
Interventions: PROCEDURE: Intraocular caliper-assisted capsulotomy|PROCEDURE: Verion navigation system-assisted capsulotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Post Acute Sequelae of COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19|Sars-CoV-2 Infection|Dyspnea Caused by 2019-nCoV|COVID-19 Acute Respiratory Distress Syndrome|Pulmonary Fibrosis
Interventions: OTHER: Cohort study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patient-centered Goal Setting in the National Diabetes Prevention Program
Status: RECRUITING
Conditions: PreDiabetes
Interventions: BEHAVIORAL: NDPP-Flex|BEHAVIORAL: NDPP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Frequency of Pes Planus and Posterior Tibial Tendon Dysfunction in Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Posterior Tibial Tendon Dysfunction|Pes Planus|Spondylitis, Ankylosing
Interventions: OTHER: Patients with Ankylosing Spondylitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Vitreous Delineating Agent During Vitrectomy
Status: COMPLETED
Conditions: Vitrectomy
Interventions: DRUG: Triamcinolone Acetonide Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Post-discharge educatıon provıded vıa Tele-nursıng to Elderly patıents
Status: COMPLETED
Conditions: Tele-Nursing
Interventions: BEHAVIORAL: Education provided via TeleNursing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diuresis, Functional Bladder Capacity and LUTS in CKD and ESRD Patients.
Status: COMPLETED
Conditions: Lower Urinary Tract Symptoms|End Stage Renal Disease
Interventions: DIAGNOSTIC_TEST: ICIQ questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: DRUG: Pure oxygen (99%) from Praxair, Edmonton, DIN# 02014408
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areas
Status: COMPLETED
Conditions: Sickle Cell Anemia|Sickle Cell Disease|Malaria
Interventions: DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Manual Cardiopulmonary Resuscitation (CPR) Versus Automatic CPR Machine During Ambulance Transport.
Status: UNKNOWN
Conditions: Cardiac Arrest|Cardiopulmonary Resuscitation
Interventions: DEVICE: Automatic CPR machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Bosentan Therapy in Patients With Systemic scleRosis and Progressive Digital ulcEr Disease.
Status: RECRUITING
Conditions: Scleroderma|Digital Ulcer|Autoimmune Diseases|Diffuse Cutaneous Systemic Sclerosis|Reynold Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide
Status: TERMINATED
Conditions: Nasal Polyps
Interventions: DRUG: Furosemide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Advanced Platelet Rich Fibrin and Enamel Matrix Derivative on Clinical and Molecular Wound Healing Parameters After Surgical Removal of Mandibular Third Molars
Status: ACTIVE_NOT_RECRUITING
Conditions: Surgical Wound, Healed|Post Operative Pain
Interventions: BIOLOGICAL: Advanced platelet rich fibrin (APRF) clots|DEVICE: Enamel matrix derivative (EMD) group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Radiometabolic Therapy With 177Lu PSMA in PSMA PET/CT Positive Advanced/Metastatic Tumours:
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: [177Lu]Lu-PSMA I&T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Kidney Injury in Coronavirus Disease-19 (COVID-19) Patients Admitted to the Intensive Care Unit (ICU)
Status: COMPLETED
Conditions: Critical Illness|COVID-19 Pneumonia|Acute Kidney Injury
Interventions: OTHER: Observational study exploring the epidemiology and outcomes of AKI in critical COVID-19 patients admitted to the ICU
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Multiple Doses of Lasmiditan in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Probe Drug Cocktail|DRUG: Lasmiditan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prevention of Combat-related PTSD Using Attention Bias Modification (ABM): A Randomized Controlled Trial
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Active ABMT8|BEHAVIORAL: Active ABMT4|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Orsi Surgical Skills E-learning Trial
Status: COMPLETED
Conditions: Surgery|E-learning
Interventions: PROCEDURE: Online course with proficiency test|PROCEDURE: Online course|PROCEDURE: Standard training group|PROCEDURE: Apprenticeship group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of Discontinuation of Benzodiazepine-derivative Hypnotics on Cognitive and Motor Functions in Elderly Persons
Status: COMPLETED
Conditions: Adverse Effects
Interventions: DRUG: Drug: Benzodiazepine (listed out below)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Femoral Arterial Puncture for Interventional Neuro-radiology in Children
Status: RECRUITING
Conditions: Retrograde Femoral Catheterism
Interventions: DEVICE: Ultrasound guided femoral puncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients
Status: UNKNOWN
Conditions: Respiratory Failure|Sepsis|Multiple Organ Dysfunction Syndrome
Interventions: DEVICE: electric acupuncture|OTHER: conservative
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Exercises for Low Back Pain.
Status: ENROLLING_BY_INVITATION
Conditions: Treatment Adherence|Treatment Compliance
Interventions: DEVICE: Chatbot|OTHER: Home exercise, usual care|OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of HG146 Capsule in Chinese Subjects With Relapsed and Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma|Relapsed and Refractory Multiple Myeloma
Interventions: DRUG: HG146
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) and Safety Study of Plasma-derived Human Butyrylcholinesterase Administered Intravenously
Status: COMPLETED
Conditions: Healthy Volunteers|Chemical Terrorism|Chemical Warfare
Interventions: DRUG: Human Butyrylcholinesterase (HuBChE) derived from human plasma|DRUG: Placebo: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Loss of RESponse to Ustekinumab Treated by Dose Escalation
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: DRUG: Ustekinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: Acetyl-l-carnitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Magnesium Supplementation on Type II Diabetes Mellitus Guided by Serum Ionized Magnesium Level
Status: RECRUITING
Conditions: Type 2 Diabetes|Magnesium Disorder
Interventions: DIETARY_SUPPLEMENT: Magnesium Oxide tablet 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Android Artificial Pancreas System (Android APS) Versus Control-IQ
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 1
Interventions: DEVICE: Insulin Pump t:slim X2 with Control-IQ technology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Visit 1: Clinical exam and questionnaires|OTHER: Visit 1: Respiratory physiology|OTHER: Visit 1: Inflammometry|OTHER: Visit 2: Clinical exam and questionnaires|OTHER: Visit 2: Respiratory physiology|OTHER: Visit 2: Inflammometry|OTHER: Visit 3: e-mail
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of Concomitant Administration of RotaTeq™ (V260) and the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Healthy Japanese Infants (V260-060)
Status: COMPLETED
Conditions: Rotavirus Disease
Interventions: BIOLOGICAL: RotaTeq™ (V260)|BIOLOGICAL: DTP-IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial of CS-747 (Prasugrel) Compared With Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases
Interventions: DRUG: Prasugrel (CS-747)|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bulimia Nervosa and Binge Eating Disorder: Comparing Therapeutic Strategies
Status: UNKNOWN
Conditions: Bulimia Nervosa|Binge-Eating Disorder
Interventions: DEVICE: tVNS|DEVICE: rTMS|BEHAVIORAL: CBT-E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Trends During Blood Transfusions in Newborns.
Status: NOT_YET_RECRUITING
Conditions: Blood Transfusion Complication|Blood Transfusion Associated Adverse Reactions|Respiratory Complication|Respiratory Morbidity
Interventions: DIAGNOSTIC_TEST: lung ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Maximum Tolerated Dose, Safety and Efficiency of MSC11FCD Therapy to Recurrent Glioblastoma Patients
Status: COMPLETED
Conditions: Glioblastoma|Adult Gliosarcoma|Neoplasms, Brain|Neoplasms, Germ Cell and Embryonal|Recurrent Glioblastoma
Interventions: DRUG: MSC11FCD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Bed SPECT/CT Versus Planar Bone Scintigraphy in Detection of Osseous Metastases in Patients With Genitourinary Malignancies
Status: NOT_YET_RECRUITING
Conditions: Bone Metastases|Urogenital Cancer
Interventions: RADIATION: Tc-99m MDP and gamma camera
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva
Status: UNKNOWN
Conditions: Lichen Sclerosus of Vulva
Interventions: DRUG: PRGF|DRUG: Clobetasol Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Trial of Eutectic Lidocaine/Prilocaine Cream 5% (EMLA) for Analgesia Prior to Cryotherapy of Verrucae Plantaris
Status: UNKNOWN
Conditions: Plantar Warts
Interventions: DRUG: EMLA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Phase I/II Study of Postoperative Adjuvant Chemoradiation for Advanced-Stage Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN)
Status: WITHDRAWN
Conditions: Recurrent Skin Cancer|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Squamous Cell Carcinoma of the Skin|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity
Interventions: DRUG: erlotinib hydrochloride|DRUG: linsitinib|DRUG: placebo|RADIATION: radiation therapy|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of Hypnosis in Virtual Reality on Nociception During Oocyte Retrieval in a Medically Assisted Reproduction Procedure
Status: COMPLETED
Conditions: Oocyte Retrieval
Interventions: DRUG: local anaesthetic injection|DEVICE: hypnosis with Virtual reality mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose Ranging Trial of GSK1349572 and 2 NRTI in HIV-1 Infected, Therapy Naive Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: GSK1349572|DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Seal-G / Seal-G MIST Study
Status: COMPLETED
Conditions: Colon Cancer|Gastrointestinal Cancer
Interventions: DEVICE: Seal-G Surgical Sealant|DEVICE: Seal-G MIST System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Outcomes of Surgical Management of Temporomandibular Joint Anterior Disc Displacement Without Reduction
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Joint Disc Displacement, Without Reduction
Interventions: PROCEDURE: discectomy of the TMJ disc|PROCEDURE: TMJ discopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: BR1015|DRUG: BR1015-1|DRUG: BR1015-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Caregiver Implementation of an Effective Early Learning Intervention
Status: RECRUITING
Conditions: Developmental Language Disorder|Reading; Difficult
Interventions: OTHER: Sit Together and Read (STAR)|BEHAVIORAL: Monetary Reward|BEHAVIORAL: Text Encouragement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety, Pharmacokinetics and Tolerability of BMS-708163
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: BMS-708163 (Gamma-Secretase Inhibitor)|DRUG: Placebo matching BMS-708163|DRUG: Placebo matching BMS-708163
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Foundations for Health
Status: COMPLETED
Conditions: Overweight|Obese
Interventions: BEHAVIORAL: Decrease Energy Density of the Diet|BEHAVIORAL: Increase Steps per Day|BEHAVIORAL: Consumption of Self-made Meals
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Ankle-foot Orthosis Improves Gait Performance and Satisfaction in Stroke Patients
Status: COMPLETED
Conditions: Gait Analysis
Interventions: DEVICE: 3D printing AFO, anterior AFO, off-the-shelf AFO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Lenalidomide, Ibrutinib, and Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma That Is Metastatic or Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Chronic Lymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Small Lymphocytic Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|PROCEDURE: Electrocardiogram|DRUG: Ibrutinib|DRUG: Lenalidomide|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Etanercept Treatment of Patients With Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Enbrel (etanercept)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ovulation Inhibition of Two 4-phasic Oral Contraceptive Regimens
Status: COMPLETED
Conditions: Ovulation Inhibition
Interventions: DRUG: EV/DNG (Qlaira, BAY86-5027, SH T00658K)|DRUG: EV/DNG (SH T00658L)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12 Day Study To Evaluate A Topical Drug To Treat Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: PF06263276|OTHER: Vehicle|DRUG: 2%Tofacitinib Ointment|OTHER: Vehicle|DRUG: Daivonex|DRUG: Daivonex Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New York City Eye Study (NYCES)
Status: NOT_YET_RECRUITING
Conditions: Glaucoma|Vision Impairment and Blindness|Cataract|Diabetic Retinopathy
Interventions: OTHER: Intervention Using Patient Navigators|OTHER: Usual Care Without Patient Navigators
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: tDCS in MCS: Repeated Stimulations
Status: COMPLETED
Conditions: Patients in Minimally Conscious State After a Severe Brain Injury (e.g., Anoxia, Traumatic Brain Injury, Stroke)
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nitrous Oxide for External Cephalic Version
Status: COMPLETED
Conditions: External Cephalic Version
Interventions: DRUG: Nitrous Oxide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NVA237 as an add-on to Fixed Dose Combination LABA/ICS
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: NVA237|DRUG: Placebo to NVA237
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Of Erlotinib With Or Without PF-3512676 In Advanced Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: PF-3512676 + Erlotinib|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Caries Prevention Effect of Fissure Sealants
Status: COMPLETED
Conditions: Caries Prevention|Fissure Sealant|Fluoride Concentration|Glass Ionomer Cement|Resin
Interventions: PROCEDURE: Fissure sealant application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study of NNZ-2566 in Pediatric Rett Syndrome
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: DRUG: NNZ-2566|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases
Status: COMPLETED
Conditions: Cognitive Impairment|Metastatic Malignant Neoplasm in the Brain|Solid Neoplasm
Interventions: RADIATION: Whole brain radiation therapy with hippocampal avoidance|DRUG: Memantine|RADIATION: Whole brain radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: REGISTRY on the Implementation of Artificial Intelligence in the Automatic Analysis of Vascular Network Segmentation
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm
Interventions: PROCEDURE: Analyze CTscans pre-operatively by Nurea System|PROCEDURE: Analyze CTscans pre-operatively by hospital practitioner
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Transcranial Direct Current Stimulation to Treat Epilepsy
Status: RECRUITING
Conditions: Focal Epilepsy
Interventions: DEVICE: ActivaDose II 0.1 mA transcranial direct current stimulation (tDCS)|DEVICE: ActivaDose II 2.0 mA transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEoadjuvant Dose-dense MVAC In cOmbination With Durvalumab and Tremelimumab in Muscle-invasive Urothelial Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Infiltrating Bladder Urothelial Carcinoma
Interventions: DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: MVAC Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Patients With Metastatic, Recurrent, or Refractory Primitive Neuroectodermal Tumors
Status: TERMINATED
Conditions: Primitive Neuroectodermal Tumor
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of Omega Refractive Capsule, Model VI
Status: ACTIVE_NOT_RECRUITING
Conditions: Cataract
Interventions: DEVICE: Omega Refractive Capsule with an FDA approved Intraocular Lens|DEVICE: FDA approved Intraocular Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Cleaning Using Povidone Iodine Before CS to Reduce Postoperative Wound Infection
Status: UNKNOWN
Conditions: Cesarean Section Complications|Vaginal Infection|Postoperative Infection
Interventions: DRUG: 10% povidone iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Quadratus Lumborum Block With the Transversus Abdominis Plan Block
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: quadratus lumborum block|PROCEDURE: Transversus abdominis plan block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Iron From Savoury Food Product
Status: COMPLETED
Conditions: Healthy|Iron Deficiency
Interventions: OTHER: Savoury food product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Reproductive Cycle and Menopause on HIV-1 Infection and TFV Gel Activity
Status: COMPLETED
Conditions: HIV Prevention
Interventions: DRUG: TFV 1% gel|DRUG: Estradiol vaginal cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Investigation of the Effect of Preoperative Education on Postoperative Outcomes in Total Knee Arthroplasty Patients
Status: UNKNOWN
Conditions: Knee Osteoarthritis|Pain, Postoperative|Kinesiophobia
Interventions: OTHER: preoperative education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of Anastrozole +/- AZD8931 in Postmenopausal Women With Endocrine Therapy Naive Breast Cancer
Status: TERMINATED
Conditions: Neoplasms|Breast Neoplasms|Breast Cancer
Interventions: DRUG: AZD8931|DRUG: anastrozole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RFA to Prevent Metachronous Squamous Neoplasia Recurrence After Complete Endoscopic Submucosal Dissection
Status: RECRUITING
Conditions: Esophageal Squamous Cell Neoplasm
Interventions: PROCEDURE: Radiofrequency ablation|DEVICE: Endoscopy|DRUG: Lugol's Solution (1.5%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of BIA 2-093 on the Steady-state Pharmacodynamic and Pharmacokinetic Profiles of Warfarin
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anti-CD33/CLL1 CAR-NK in Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: Anti-CD33/CLL1 CAR-NK Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Osteopathic Manipulative Treatment Associated With Pain Education and Clinical Hypnosis
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Education in pain neurosciences and clinical hypnosis|OTHER: Education in pain neurosciences and clinical hypnosis plus osteopathic manipulative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Program Interest "Bouge" to Improve the Daily Physical Activity in Processings Treatment of Non-metastatic Breast Cancer
Status: UNKNOWN
Conditions: Physical Activity|Breast Cancer|Mobile Health Apps
Interventions: DEVICE: Smartphone application "placebo"|DEVICE: Smartphone equipped with application "bouge" = Coach group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Perioperative Chemotherapy Plus Panitumumab in Patients With Colorectal Cancer Liver Metastases
Status: COMPLETED
Conditions: Colorectal Cancer|Liver Metastases
Interventions: DRUG: Panitumumab, Oxaliplatin, 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modulation of Gut Microbiota by Probiotic in Children With Respiratory Symptoms
Status: RECRUITING
Conditions: Respiratory Infection (for Example, Pneumonia, Bronchitis)
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic First in Human (FIH) Study for Intravenous (IV) TKM-100802
Status: TERMINATED
Conditions: Ebola Virus Infection
Interventions: DRUG: TKM-100802 for Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Translational and Clinical Aspects of Metabolic, Anabolic and Endothelial Dysfunction in Heart Failure
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction HFrEF
Interventions: BIOLOGICAL: Ghrelin|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of Xenin-25 in Humans With and Without Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: Placebo|DRUG: Glucose-dependent Insulinotropic Polypeptide (GIP)|DRUG: Xenin-25|DRUG: Glucose-dependent Insulinotropic Polypeptide plus Xenin-25
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion
Status: RECRUITING
Conditions: Malignant Pleural Effusion
Interventions: DRUG: JMKX000197
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent, or Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Theraputic Drug Monitoring and Phamacokinetics of Isavuconazole in Children
Status: NOT_YET_RECRUITING
Conditions: Aspergillosis Invasive|Mucormycosis
Interventions: OTHER: Theraputic drug monitoring|DRUG: Isavuconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bile Composition in Healthy and Gallstones Patients
Status: UNKNOWN
Conditions: Cholelithiasis|Gall Stone|Gall Bladder Disease
Interventions: DIAGNOSTIC_TEST: Bile test|DIAGNOSTIC_TEST: Blood test|DIAGNOSTIC_TEST: Gall stone study|DIAGNOSTIC_TEST: Microbiological bile test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Regorafenib Plus Programmed Cell Death-1 (PD-1) Inhibitors in Patients With Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Advanced Colorectal Carcinoma
Interventions: DRUG: Regorafenib|DRUG: Nivolumab|DRUG: Pembrolizumab|DRUG: Camrelizumab|DRUG: Sintilimab|DRUG: Toripalimab|DRUG: Tislelizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect Of Probiotic Lactobacillus Paracasei Lp-33 For The Management Of Rhinitis In People Sensitized To Allergens
Status: COMPLETED
Conditions: Rhinitis
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Lactobacillus paracasei LP-33
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exploration of the Mechanisms of Vulnerability of Anorexia Nervosa at an Early Age : Study of the Cognitive Treatment of Food Stimuli and Body Image
Status: UNKNOWN
Conditions: Anorexia Nervosa
Interventions: OTHER: STUDY OF THE COGNITIVE TREATMENT OF DIETARY STIMULI AND BODY IMAGE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Rasagiline on Cognitive Deficits Associated With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease
Interventions: DRUG: placebo|DRUG: rasagiline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Duloxetine in Patients With Suspected Functional Pancreatic/Biliary Pain (Sphincter of Oddi Dysfunction)
Status: COMPLETED
Conditions: Sphincter of Oddi Dysfunction
Interventions: DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of the Catechol-O-methyltransferase (COMT) in the Physiological Regulation of Vigilance
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tolcapone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
Status: RECRUITING
Conditions: Wheezing|Asthma
Interventions: DRUG: Dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Fermented Dairy Beverage in Cervical Cancer Patients Undergoing Concurrent Chemoradiation Therapy
Status: COMPLETED
Conditions: Cervical Cancer, Stage IIB
Interventions: OTHER: Placebo dairy beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Pilot Study to Compare the Bioavailability of Buffered, Enteric-Coated Ursodiol With Unmodified Ursodiol for Chronic Cholestatic Liver Disease and Cystic Fibrosis-Associated Liver Disease
Status: UNKNOWN
Conditions: Cystic Fibrosis|Gastrointestinal Diseases|Cholestasis
Interventions: DRUG: ursodiol
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Explore the Role of Gut Flora in Metastatic Mesothelioma
Status: UNKNOWN
Conditions: Mesothelioma|Mesothelioma Malignant|Mesothelioma; Lung|Mesotheliomas Pleural|Mesothelioma Peritoneum|Mesothelioma; Liver|Mesothelioma; Omentum
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months
Status: COMPLETED
Conditions: Acute Otitis Media
Interventions: COMBINATION_PRODUCT: OP0201|COMBINATION_PRODUCT: Placebo|DRUG: Amoxicillin-clavulanate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Program for Weaning From Mechanical Ventilator
Status: COMPLETED
Conditions: Mechanical Ventilation Complication
Interventions: OTHER: Comprehensive physical therapy rehabilitation program combined with inspiratory muscle training|OTHER: Traditional chest physical therapy rehabilitation program combined with inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intrathecal Fentanyl on Spinal Anesthesia During Dexmedetomidine Infusion
Status: COMPLETED
Conditions: Anesthesia, Spinal
Interventions: DRUG: fentanyl|DRUG: bupivacaine only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predicting Weight Gain and Weight Loss Associated With Overeating or Fasting
Status: COMPLETED
Conditions: Obesity|Diet Therapy|Weight Loss|Weight Gain|Nutrition Therapy
Interventions: BEHAVIORAL: Weight Loss|BEHAVIORAL: Overfeeding|BEHAVIORAL: Overfeeding Low Pro
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Movement and Behaviours Measurement Study
Status: RECRUITING
Conditions: Aging|Physical Function|Frailty Syndrome|Physical Disability|Lifestyle, Sedentary
Interventions: BEHAVIORAL: Older Adults Group.|BEHAVIORAL: Low Physical Function Status Group|BEHAVIORAL: Medium Physical Function Status Group|BEHAVIORAL: High Physical Function Status Group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Protocol for Assistance to Patients With Long Covid-19 Undergoing Treatment With HD-tDCS
Status: UNKNOWN
Conditions: Coronavirus|COVID-19 Respiratory Infection
Interventions: DEVICE: Experimental group/ Active HD-tDCS|DEVICE: Control Group / Sham Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Multi-Center Biomarker Trial to Predict Therapeutic Responses of Patients With Rheumatoid Arthritis to a Specific Biologic Mode of Action
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Remicade|DRUG: Orencia|DRUG: Ro-Actemra|DRUG: Mabthera
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ELUCIDATE: Enabling Lung Cancer Identification Using Folate Receptor Targeting
Status: COMPLETED
Conditions: Lung Neoplasms|Lung Cancer
Interventions: DRUG: OTL38 for Injection|DEVICE: Near infrared camera imaging system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Pharmacodynamics, Pharmacokinetics, Safety, and Efficacy of UB-221 IV Infusion as an add-on Therapy in Patients With Chronic Spontaneous Urticaria
Status: RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: UB-221|OTHER: sterile saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Compare Effects of Ultrasound Therapy With High Intensity Laser Therapy for Treatment of Lumbar Disc Herniation.
Status: COMPLETED
Conditions: Disk Herniated Lumbar
Interventions: OTHER: Ultrasound Therapy|OTHER: High Intensity Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate Safety, Tolerability, PK and Antiviral Activity of MB-110 in Hepatitis C Virus Infected Patients
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: MB-110|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fontan Udenafil Exercise Longitudinal Assessment Trial
Status: COMPLETED
Conditions: Single Ventricle Heart Disease
Interventions: DRUG: Udenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-Articular Morphine Versus Bupivacaine on Knee Motion in Patients With Osteoarthritis
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating AVM0703 for Treatment of COVID-19 or Influenza-mediated ARDS
Status: NOT_YET_RECRUITING
Conditions: ARDS|Covid19|Influenza, Human
Interventions: DRUG: AVM0703|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of TR-701 in Patients With Complicated Skin and Skin Structure Infections
Status: COMPLETED
Conditions: Skin Diseases, Infectious|Skin Diseases, Bacterial
Interventions: DRUG: TR-701 200 mg|DRUG: TR-701 300 mg|DRUG: TR-701 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Dose-escalation Study of Lutetium-177-labeled cG250 in Patients With Advanced Renal Cancer
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: 111-In-DOTA-cG250|DRUG: 177-Lu-DOTA-cG250
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of Tariquidar + Vinorelbine as First-Line Therapy in Non-Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Stage IIIb Non-small Cell Lung Cancer|Stage IV Non-small Cell Lung Cancer
Interventions: PROCEDURE: Chemotherapy|DRUG: tariquidar + vinorelbine|DRUG: placebo + vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose:
Clinical trial: Efficacy of 20% Autologous Serum Drops in the Treatment of Corneal Epitheliopathy Associated With Antihypertensive Glaucoma Drops.
Status: NOT_YET_RECRUITING
Conditions: Corneal Epitheliopathy|Glaucoma|Corneal Disease|Dry Eye
Interventions: BIOLOGICAL: 20% ASED + AT|DRUG: 0.9% NS + AT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Feasibility, Safety, and Efficacy of Single-use Endobronchial Silicon Spigots for the Treatment of Refractory Pneumothorax
Status: RECRUITING
Conditions: Pneumothorax
Interventions: DEVICE: Endobronchial Silicon Spigots
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Cordycepin Plus Pentostatin in Patients With Refractory TdT-Positive Leukemia
Status: UNKNOWN
Conditions: Refractory TdT-Positive Leukemia
Interventions: DRUG: Cordycepin plus Pentostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Childhood B Acute Lymphoblastic Leukemia|Childhood T Acute Lymphoblastic Leukemia|Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Lymphoblastic Lymphoma
Interventions: DRUG: Dexamethasone|OTHER: Laboratory Biomarker Analysis|DRUG: Methotrexate|DRUG: Mitoxantrone Hydrochloride|DRUG: Pegaspargase|OTHER: Pharmacological Study|DRUG: Temsirolimus|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT