pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia
Status: COMPLETED
Conditions: Lip and Oral Cavity Cancer|Oral Leukoplakia|Oropharyngeal Cancer|Tongue Cancer
Interventions: DRUG: Bowman-Birk inhibitor concentrate|OTHER: placebo|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Perineural Dexamethasone and bupivacaine|DRUG: Systemic Dexamethasone plus perineural bupivacaine|DRUG: intravenous saline plus perineural bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Evaluation of Immunogenicity and Safety of NBP608 in Healthy Children 12 Months to 12 Years of Age
Status: COMPLETED
Conditions: Varicella
Interventions: BIOLOGICAL: NBP608|BIOLOGICAL: Varivax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: New Drugs in the Treatment of Mood Disorders
Status: COMPLETED
Conditions: Anxiety Disorder|Mood Disorder|Psychotic Disorder
Interventions: DRUG: Lamotrigine (Lamictal® (Registered Trademark)|DRUG: Gabapentin (Neurontin® (Registered Trademark))
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Transcranial Electrical Polarization to Treat Focal Hand Dystonia
Status: COMPLETED
Conditions: Dystonia|Focal Hand Dystonia|FHD
Interventions: PROCEDURE: Transcranial Electrical Polarization (TEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Effect of Interscapular Cupping on Chest Expansion in Sedentary Male Smokers
Status: UNKNOWN
Conditions: Smoking
Interventions: OTHER: wet cupping|OTHER: dry cupping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: How Do Structural Social Determinants of Health Affect AKT-MP and Outcomes
Status: WITHDRAWN
Conditions: Kidney Diseases|Social Determinants of Health
Interventions: OTHER: Kidney Transplant Fast Track (KTFT)|OTHER: Peer Navigation (PN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CODY (Co-design for You): An Immersive Technology Tool for Experiencing and Assessing Home Alterations
Status: COMPLETED
Conditions: Parkinson Disease (PD)
Interventions: OTHER: Doorway Width Test|OTHER: Door Frame Color Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Conversion To Monotherapy With Lamictal Extended Release Tablets For Treatment Of Partial Epilepsy
Status: COMPLETED
Conditions: Epilepsy, Partial
Interventions: DRUG: lamotrigine, 300 mg/day|DRUG: lamotrigine, 250 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Intractable Common Extensor Tendon Injury Using Mesenchymal Stem Cells (Allo-ASC)
Status: UNKNOWN
Conditions: Lateral Epicondylitis
Interventions: BIOLOGICAL: High concentration of Allo-ASC|BIOLOGICAL: Low concentration of Allo-ASC|DRUG: Fibrin glue|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EARLY Routine Catheterization After Alteplase Fibrinolysis vs. PPCI in ST-Segment-Elevation MYOcardial Infarction
Status: COMPLETED
Conditions: Acute ST-segment Elevation Myocardial Infarction
Interventions: DRUG: Alteplase|PROCEDURE: Early post-fibrinolytic catheterisation|PROCEDURE: Primary PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Sleep Apnea System for the Treatment of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Attune Sleep Apnea System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Motor Tasks and Lidocaine on Reading Unfamiliar Words in Adults With and Without Dyslexia
Status: RECRUITING
Conditions: Reading Disorders
Interventions: DRUG: Lidocaine 2% Polyampoule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Relationship Between Morbimortality and Basal Activated Clotting Time (ACT) in Patients Undergoing Vascular Surgery
Status: UNKNOWN
Conditions: Artery Disease, Peripheral|Aortic Diseases|Carotid Artery Diseases|Other Disease
Interventions: DIAGNOSTIC_TEST: Activated clotting time
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DZD8586 in Patients With Relapsed or Refractory CLL/SLL (TAI-SHAN8)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Interventions: DRUG: DZD8586|DRUG: DZD8586|DRUG: DZD8586
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Electroretinogram Pattern (Diopsys® NOVA System) for the Early Diagnosis of Glaucoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma
Interventions: DEVICE: Electroretinogram Pattern (Diopsys® NOVA System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D )
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke, Acute
Interventions: COMBINATION_PRODUCT: Emergency Stroke Unit based on 0.23-T MRI|COMBINATION_PRODUCT: Standard stroke unit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DEB-TACE vs. cTACE as Conversion Therapy for Unresectable Large HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma Non-resectable
Interventions: PROCEDURE: Drug-eluting bead transarterial chemoembolization (DEB-TACE)|PROCEDURE: Conventional transarterial chemoembolization (cTACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Surgery|Target Controlled Infusion
Interventions: DEVICE: Target Controlled Infusion|DRUG: Inhalation anesthetic
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing the Quality of Life Between LADG and TLDG for Gastric Cancer_KLASS07 (CKLASS01)).
Status: COMPLETED
Conditions: Quality of Life|Gastric Cancer|Surgery|Surgical Complication
Interventions: PROCEDURE: TLDG arm|PROCEDURE: LADG arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine With Peptide Vaccine Therapy in Treating Patients With Bile Duct Cancer
Status: SUSPENDED
Conditions: Bile Duct Cancer
Interventions: BIOLOGICAL: Peptide vaccine for URLC10|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peanut Oral Immunotherapy and Anti-Immunoglobulin E (IgE) for Peanut Allergy
Status: COMPLETED
Conditions: Peanut Hypersensitivity
Interventions: DRUG: Peanut Oral Immunotherapy|DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis
Status: TERMINATED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Steroid-Refractory Pneumonitis
Interventions: BIOLOGICAL: Infliximab|BIOLOGICAL: Intravenous Immunoglobulin Therapy|DRUG: Prednisone|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Plasma Combined With Human Umbilical Cord Mesenchymal Stem Cells for Stage 3 and 4 Stress Injury
Status: RECRUITING
Conditions: Pressure Injuries - Stage 3|Pressure Injuries - Stage 4
Interventions: BIOLOGICAL: Platelet-rich plasma (PRP) combined with human umbilical cord mesenchymal stem cells (huMSCs)|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Physiologic Effects of KB109 in Patients With COVID-19 on Gut Microbiota Structure and Function
Status: COMPLETED
Conditions: Mild-to-Moderate COVID-19
Interventions: OTHER: KB109 + Self Supportive Care (SSC)|OTHER: Self Supportive Care (SSC) Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Protege Encore Study- Clinical Trial of Teplizumab (MGA031) in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: Teplizumab Herold Regimen|DRUG: Placebo|BIOLOGICAL: Teplizumab 33.3% Herold Regimen|BIOLOGICAL: Teplizumab Curtailed Herold Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind Randomized Clinical Trial Comparing the Safety and Antiviral Activity of 48-week Clevudine and Adefovir Dipivoxil in HBeAg(-) Chronic Hepatitis B With Compensated Liver Function
Status: COMPLETED
Conditions: HBeAg(-) Chronic Hepatitis B With Compensated Liver Function
Interventions: DRUG: Clevudine|DRUG: Adefovir dipivoxil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing the Tolerability of Etravirine to Efavirenz in Combination With 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Treatment-naive HIV-1 Infected Patients
Status: COMPLETED
Conditions: HIV Infection|HIV|Acquired Immunodeficiency Syndrome
Interventions: DRUG: etravirine (ETR, TMC125)|DRUG: efavirenz (EFV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treating Smokeless Tobacco Use in Rural Veterans
Status: UNKNOWN
Conditions: Smokeless Tobacco|Nicotine Dependence
Interventions: BEHAVIORAL: Tailored behavioral intervention|BEHAVIORAL: Behavioral activation for elevated depressive symptoms|BEHAVIORAL: Post-cessation weight gain management|BEHAVIORAL: Alcohol use risk reduction|DRUG: Nicotine replacement therapy - transdermal nicotine patch|DRUG: Nicotine replacement therapy - nicotine lozenge|DRUG: Nicotine replacement therapy - nicotine gum|DRUG: Bupropion sustained release|DRUG: Varenicline|DRUG: Combination nicotine replacement therapy|DRUG: Combination nicotine replacement therapy + bupropion|BEHAVIORAL: Tobacco quit line|BEHAVIORAL: Educational materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Diseases, Interstitial
Interventions: DRUG: Nintedanib (Ofev®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Renal Failure
Status: COMPLETED
Conditions: Acute Renal Failure
Interventions: DEVICE: Selective cytopheretic device (SCD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for Treatment of Radiation-related Fatigue in Patients Receiving RT for Head-neck and Lung Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mouth Odor on Preventing Pneumonia by Oral Frailty
Status: RECRUITING
Conditions: Breathing, Mouth|Pneumonia|Frailty
Interventions: PROCEDURE: Oral exercises and oral hygiene|PROCEDURE: Oral care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Fecal Microbiota Transplantation (FMT) in Irritable Bowel Syndrome (IBS)
Status: RECRUITING
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: FMT via rectal enema|DRUG: FMT capsules|DRUG: Placebo via rectal enema|DRUG: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Compare 1.0 Versus 2.0 mg Alteplase (tPA) Dosing in Restoring Hemodialysis Catheter Function
Status: UNKNOWN
Conditions: Kidney Disease
Interventions: DRUG: Alteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Mindful Self-compassion Based Intervention for Specialist Rehabilitation Providers
Status: ACTIVE_NOT_RECRUITING
Conditions: Burnout, Professional|Compassion Fatigue|Secondary Traumatic Stress
Interventions: OTHER: Mindfulness Self-Compassion Course
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Painless 5-aminolevulinic Acid Photodynamic Therapy for Moderate and Severe Acne Vulgaris
Status: UNKNOWN
Conditions: Acne
Interventions: PROCEDURE: Aminolevulinic acid photodynamic therapy|DRUG: Oral conventional-dose isotretinoin|DRUG: Oral low-dose isotretinoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BATTLE-FL: Front-Line Biomarker-Integrated Treatment Study in Non Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Bevacizumab|DRUG: Cixutumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ultrasound Versus Short Wave Diathermy in the Treatment of a Slipped Disc of the Lower Back
Status: COMPLETED
Conditions: Radiculopathy|Low Back Pain, Mechanical|Herniated Disk Lumbar
Interventions: DEVICE: Ultrasound group|DEVICE: Short wave diathermy group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia
Status: ACTIVE_NOT_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: Pimavanserin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation
Status: UNKNOWN
Conditions: Refractory Chronic Cluster Headache
Interventions: RADIATION: 18F-FDG PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety Study of Transvenous Limb Perfusion in Human Muscular Dystrophy
Status: COMPLETED
Conditions: Muscular Dystrophies|Duchenne Muscular Dystrophy|Becker Muscular Dystrophy|Limb-Girdle Muscular Dystrophy
Interventions: OTHER: Retrograde high pressure transvenous perfusion with normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Roflumilast to Treat Scalp and Body Psoriasis (ARRECTOR)
Status: COMPLETED
Conditions: Scalp Psoriasis
Interventions: DRUG: ARQ-154 Foam 0.3%|DRUG: ARQ-154 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chidamide Combined With Fulvestrant for HR+/HER2-advanced Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Hormone Receptor-positive Advanced Breast Cancer
Interventions: DRUG: chidamide，fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ES16001 in Patients With COVID-19
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: ES16001 40 mg|DRUG: ES16001 80 mg|DRUG: ES16001 160 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Injection to Treat Diffuse Esophageal Spasm
Status: UNKNOWN
Conditions: Esophageal Spasm, Diffuse
Interventions: DRUG: Placebo|DRUG: Botulinum Toxin Type A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Doxycycline, Temozolomide and Ipilimumab in Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Doxycycline|DRUG: Ipilimumab|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: RADIATION: Intensity-modulated radiation therapy|DRUG: 5-fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: Capecitabine|RADIATION: Accelerated Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Avacopan|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder
Status: RECRUITING
Conditions: Substance-Related Disorders
Interventions: DRUG: Rotigotine Transdermal System [Neupro]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Human Lab Model for Screening AUD Medications
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Placebo|DRUG: Naltrexone|DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peginterferon Alfa-2a Plus Ribavirin Combination Treatment in Chronic Hepatitis C Post-Renal Transplant Patients
Status: COMPLETED
Conditions: Chronic Hepatitis C|Renal Transplant
Interventions: DRUG: Pegylated interferon alfa-2a plus ribavarin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study: Preoperative Nicotine Lozenges
Status: COMPLETED
Conditions: Smoking
Interventions: DRUG: Nicotine Lozenge|DRUG: Placebo Lozenge|BEHAVIORAL: Abstinence Advisement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Bismuth Subsalicylate in Clostridium Difficile Colitis
Status: WITHDRAWN
Conditions: Clostridium Difficile Infection
Interventions: DRUG: Bismuth Subsalicylate|DRUG: standard antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA (cT1-3, N0-1, M0) Breast Cancer and Positive Axillary Lymph Nodes
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetics (PK) Study of WR 279,396 Versus Paromomycin for Treatment of Cutaneous Leishmaniasis (Peru-PK)
Status: COMPLETED
Conditions: Leishmaniasis, Cutaneous
Interventions: DRUG: WR 279,396 (15% paromomycin + 0.5% gentamicin topical cream)|DRUG: Paromomycin Alone Cream (15% paromomycin topical cream)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: Ranibizumab (Lucentis)|PROCEDURE: Argon Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Long-term Major Cardiovascular Events|Myocardial Infarction|Percutaneous Coronary Intervention
Interventions: DEVICE: Percutaneous coronary intervention|DEVICE: Percutaneous coronary intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ANAVEX2-73 Study in Pediatric Patients With Rett Syndrome
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: DRUG: ANAVEX2-73 oral liquid|DRUG: Placebo oral liquid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pyrotinib Plus Vinorelbine in Patients With Brain Metastases From HER2-positive Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Brain Metastases
Interventions: DRUG: Pyrotinib Plus Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of The Safety And Efficacy Of Conversion From A CNI To Sirolimus In Renally-Impaired Heart Transplant Recipients
Status: COMPLETED
Conditions: Graft Rejection|Kidney Failure
Interventions: DRUG: cyclosporine or tacrolimus|DRUG: sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Sublingual Immunotherapy (SLIT)
Status: UNKNOWN
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: sublingual immunotherapy with allergen extract|BIOLOGICAL: sublingual immunotherapy with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun)
Status: UNKNOWN
Conditions: Hyperalgesia
Interventions: DRUG: Remifentanil|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oxygenation of Paravertebral Muscles During Exercise in Chronic Low Back Pain Patients
Status: UNKNOWN
Conditions: Low Back Pain|Rehabilitation Program|Muscular Weakness
Interventions: OTHER: Physical rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Research Examining Gulf War Illness in Our Nations Service Members
Status: TERMINATED
Conditions: Gulf War Illness
Interventions: DRUG: Duloxetine|DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Left Ventricular Volume Index in the Adjustment of Initial Dose of Dobutamine in Heart Failure and Cardiogenic Shock
Status: UNKNOWN
Conditions: Cardiogenic Shock|Heart Failure
Interventions: PROCEDURE: adjust dobutamine according to the ejection volume index|PROCEDURE: adjust dobutamine according to the attending physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Internet Mediated Research Study to Assess the Quality of Life of Consumers With Self-reported Fungal Nail Infection (Onychomycosis) During Treatment With Scholl Fungal Nail.
Status: UNKNOWN
Conditions: Onychomycosis of Toenail
Interventions: DEVICE: Fungal Nail Treatment Kit
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Safety of Ipratropium Bromide, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Ipratropium Bromide low dose|DRUG: Placebo|DRUG: Ipratropium Bromide high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The CLEVER Study - Coreg And Left Ventricular Mass Regression
Status: COMPLETED
Conditions: Hypertrophy, Left Ventricular
Interventions: DRUG: carvedilol MR|DRUG: atenolol|DRUG: lisinopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Survey on Menstrual Symptoms, Health Related Quality of Life and Work Productivity in Patients Suffering From Pain During Menstruation (Dysmenorrhea) in Japan
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DRUG: LEP|DRUG: NSAIDs and/or Chinese medicine (CM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glycyrrhetinic Acid Combined With Dexamethasone in Management of Newly Diagnosed ITP
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: Glycyrrhetinic Acid|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Protein Intake and Resistance Training in Aging
Status: COMPLETED
Conditions: Frail Elderly Syndrome
Interventions: DIETARY_SUPPLEMENT: Whey protein|DIETARY_SUPPLEMENT: whey plus creatine|DIETARY_SUPPLEMENT: leucine supplementation|DIETARY_SUPPLEMENT: soy protein|DIETARY_SUPPLEMENT: creatine|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-in-human: Single Ascending Dose, Food Effect, Drug-drug Interaction, Multiple Ascending Dose, Proof of Pharmacology
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ASP6282|DRUG: Itraconazole|DRUG: Pilocarpine|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Monitoring Pupillary Reflex Dilatation for Optimized Postoperative Opioid Delivery Before Extubation.
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DIAGNOSTIC_TEST: Pupillometry-Opioid treatment|DIAGNOSTIC_TEST: Pupillometry -standardized opioid treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Interventions to Improve the HIV PrEP Cascade Among Methamphetamine Users
Status: COMPLETED
Conditions: HIV/AIDS|Adherence, Medication|Drug Use
Interventions: BEHAVIORAL: Text Messaging|BEHAVIORAL: Peer Navigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome
Status: WITHDRAWN
Conditions: Hermanski-Pudlak Syndrome|Colitis|Cytokines|Lymphocytes|Drug Evaluation
Interventions: DRUG: Mesalamine|DRUG: Infliximab|DRUG: Corticosteroids|DRUG: 6-Mercaptopurine|DRUG: Tacrolimus|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-803 Alone or in Combination With BN-Brachyury Vaccine or Bintrafusp Alfa (M7824) for Participants With Castration Resistant Prostate Cancer
Status: WITHDRAWN
Conditions: Castration Resistant Prostate Cancer
Interventions: DRUG: Bintrafusp alfa|DRUG: N-803|BIOLOGICAL: BN-Brachyury
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell-based Immunotherapy in Mesothelioma
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: tumor lysate-loaded autologous dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3
Status: COMPLETED
Conditions: Dry Eye Syndromes|Dry Eye
Interventions: DRUG: RGN-259|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Mechanism of SMA+M1 Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: SMA+M1 Transcranial Magnetic Stimulation|DEVICE: M1 Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: NNC0194 0499 50 mg/mL|DRUG: Placebo (NNC0194-0499)|DRUG: Semaglutide 3 mg/mL|DRUG: Semaglutide placebo|DRUG: NNC0174 0833 10 mg/mL|DRUG: NNC0174 0833 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Effects of Valaciclovir Treatment in Persons With Early Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Herpes Simplex
Interventions: DRUG: Valaciclovir 500Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stent Retriever for Thrombectomy Revascularisation of Large Vessel Occlusions in Acute Ischemic Stroke(Catfish)
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Catfish|DEVICE: Solitaire FR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Delta-9-THC and Iomazenil in Healthy Humans
Status: COMPLETED
Conditions: Schizophrenia|Mental Disorders|Psychotic Disorders
Interventions: DRUG: THC and Iomazenil|DRUG: Placebo (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate MEDI0562 in Combination With Immune Therapeutic Agents in Adult Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Select Advanced Solid Tumors
Interventions: BIOLOGICAL: MEDI0562|BIOLOGICAL: Tremelimumab|BIOLOGICAL: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Computed Tomography|DRUG: Ibrutinib|BIOLOGICAL: Obinutuzumab|OTHER: Quality-of-Life Assessment|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With Hyperphosphatemia
Status: COMPLETED
Conditions: Chronic Kidney Disease|Dialysis|Hyperphosphatemia
Interventions: DRUG: MCI-196
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Afatinib for Advanced ALTRK-negative ESCC
Status: RECRUITING
Conditions: Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Afatinib|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous FerRic carbOxymaltose oN Reverse Remodeling Following Cardiac Resynchronization Therapy
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Ferric Carboxymaltose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Merit of Solifenacin in the Mitigation of Ureteral Stent-induced Pain and Lower Urinary Tract Symptoms
Status: COMPLETED
Conditions: Flank Pain|Urinary Bladder, Overactive
Interventions: DRUG: Solifenacin succinate treatment|DRUG: Oxycodone and acetaminophen combination treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation on Differences in the Magnitude of CRT Response in WOmen Versus MEN
Status: COMPLETED
Conditions: Heart Failure
Interventions: PROCEDURE: Echocardiography|BEHAVIORAL: Minnesota Living Heart Failure Questionnaire (MLHF)|PROCEDURE: Six minute walk test|BEHAVIORAL: Self assessment score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD Trial
Status: COMPLETED
Conditions: End-Stage Renal Disease
Interventions: DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glargine|DRUG: Insulin aspart|DRUG: Supplemental insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison Between 3 Solutions of Bupivacaine of Adductor Canal Block for Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Neuromuscular Training in Stroke Patients With Dysphagia
Status: COMPLETED
Conditions: Stroke|Dysphagia
Interventions: BEHAVIORAL: Oral neuromuscular training and orofacial sensory-vibration|BEHAVIORAL: Orofacial sensory-vibration stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endobronchial Ultrasound- Transbronchial Needle Aspiration (EBUS-TBNA) Versus Mediastinoscopy for Mediastinal Lymph Node Staging of Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: PROCEDURE: Endobronchial ultrasound (EBUS)|PROCEDURE: Mediastinoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma
Status: RECRUITING
Conditions: PDAC - Pancreatic Ductal Adenocarcinoma|Pancreatic Cancer
Interventions: DIAGNOSTIC_TEST: Breath test|DIAGNOSTIC_TEST: Collection of matched samples of breath, biofluids and pancreatic tissue
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical and Radiological Outcomes of Posterior Cervical Fusion With Medtronic Infinity Occipitocervical-Upper Thoracic (OCT) System
Status: RECRUITING
Conditions: Degenerative Disc Disease
Interventions: DEVICE: Medtronic Infinity Occipitocervical-Upper Thoracic System using the O-arm Imaging System and StealthStation Navigation system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound-Guided Pulsed Radiofrequency In The Treatment Of Patients With Osteoarthritis Knee (USPRFGENOAK)
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Real Pulsed Radiofrequency|PROCEDURE: Sham Pulsed Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Liposomal Trans Crocetin, LEAF-4L6715, in Patients With Acute Respiratory Distress Syndrome Due to COVID-19, Sepsis or Other Causes
Status: COMPLETED
Conditions: COVID19, Sepsis or Other Causes|Acute Respiratory Distress Syndrome
Interventions: DRUG: LEAF-4L6715
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcipotriol as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA)
Status: WITHDRAWN
Conditions: Central Centrifugal Cicatricial Alopecia
Interventions: DRUG: Calcipotriol|DRUG: Subject's already prescribed drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Readiness for E-mental Health- Awareness, Acceptance, and Preference Towards Technology-Mediated Mental Health Treatment Among Individuals With Elevated Depressive Symptoms in Hongkong
Status: RECRUITING
Conditions: Depression|Psychotherapies
Interventions: OTHER: Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients
Status: UNKNOWN
Conditions: Periodontitis and Diabetitis
Interventions: PROCEDURE: Gingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of FeNO to Identify Eosinophilic Inflammation in Patients Age 40 Years and Above With Chronic Obstructive Airways Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: NIOX MINO® Instrument (09-1100)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Persistence of the Cellular and Humoral Immune Response Following Vaccinations With GlaxoSmithKline (GSK) Biologicals' Candidate Vaccines Containing HBsAg and Different Adjuvants in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Hepatitis B
Interventions: PROCEDURE: Blood Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Two Sedation Techniques in Children Undergoing Transthoracic Echocardiography (TTE)
Status: COMPLETED
Conditions: Heart Disease
Interventions: DRUG: Dexmedetomidine|DRUG: Pentobarbital|OTHER: Oral Placebo|OTHER: Nasal Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Insulin Detemir and Insulin Aspart in 2 Separate Injections Twice Daily to Extemporaneous Mixing Injection Regimen Twice Daily - The Paediatric Mixing Trial
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin aspart|DRUG: insulin detemir|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Treatment of Urogenital Cancers Depends on the Microbiome
Status: RECRUITING
Conditions: Microbial Disease
Interventions: DRUG: Tigecycline 50 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Doses of SY-008 in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: SY-008|DRUG: SY-008 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Circulating Cell-Free Tumor DNA Testing in Guiding Treatment for Patients With Advanced or Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Colorectal Carcinoma|Stage III Colorectal Cancer AJCC v8|Stage IIIA Colorectal Cancer AJCC v8|Stage IIIB Colorectal Cancer AJCC v8|Stage IIIC Colorectal Cancer AJCC v8|Stage IV Colorectal Cancer AJCC v8|Stage IVA Colorectal Cancer AJCC v8|Stage IVB Colorectal Cancer AJCC v8|Stage IVC Colorectal Cancer AJCC v8
Interventions: OTHER: Best Practice|OTHER: Laboratory Procedure|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Regorafenib|DRUG: Trifluridine and Tipiracil Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of Orelabrutinib on Cardiac Repolarization in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Subject
Interventions: DRUG: Orelabrutinib and placebo (orelabrutinib tablet simulator)|DRUG: Orelabrutinib|DRUG: Placebo (orelabrutinib tablet simulator)|DRUG: Moxifloxacin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Validation of the Blood Glucose Measurement Device by Air Analysis Expired
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Glycemia estimated by exhaled air analyzer|BEHAVIORAL: Questionnaire|BIOLOGICAL: Veinous glycemia|BIOLOGICAL: Capillary glycemia|BIOLOGICAL: constitution biological collection|BIOLOGICAL: Blood sample|OTHER: Test meal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC