pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pancreatic Clamp in NAFLD
Status: RECRUITING
Conditions: Insulin Resistance|Prediabetic State|Hyperinsulinemia|Non-Alcoholic Fatty Liver Disease|Obesity
Interventions: DRUG: Insulin human|DRUG: Octreotide Acetate|DRUG: Glucagon|DRUG: Growth Hormone, Human|OTHER: [6,6-2H2] D-glucose|DRUG: 20% D-glucose (aq)|DIETARY_SUPPLEMENT: BOOST Plus|DIETARY_SUPPLEMENT: CORE Bar|DEVICE: Harvard Apparatus PHD ULTRA CP syringe pump|DEVICE: Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate Analyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Development of a Novel Transdiagnostic Intervention for Anhedonia - R61 Phase
Status: COMPLETED
Conditions: Anhedonia
Interventions: BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Mindfulness Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computerized Tailored Intervention for Behavioral Sequelae of PTSD in Veterans
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Smoking|Anxiety|Depression
Interventions: BEHAVIORAL: Multibehavioral, Computerized Tailored Intervention STR2IVE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Placebo-Controlled, Single and Multiple Ascending Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986089 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: BMS-986089|DRUG: Placebo matching with BMS-986089
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Trial of Routine Abdominal Wall Closure Versus Reinforcement With TIGR Matrix Onlay
Status: NOT_YET_RECRUITING
Conditions: Open Wound of Abdominal Wall With Complication
Interventions: DEVICE: TIGR Matrix|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Drainage Versus Sealant in Double Blinded Monocentric Open Incisional Hernia Repair
Status: COMPLETED
Conditions: Incisional Hernia
Interventions: DRUG: Tisseel®|PROCEDURE: Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chewing Gum Effect in Reducing Orthodontic Pain After Separator and Initial Arch Wire Placement
Status: UNKNOWN
Conditions: Orthodontic Pain
Interventions: OTHER: Wrigley Extra Strawberry Flavour Sugar Free Chewing Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Selective BRAF Kinase Inhibitor Dabrafenib Monotherapy Twice Daily and in Combination With Dabrafenib Twice Daily and Trametinib Once Daily in Combination Therapy in Subjects With BRAF V600E Mutation Positive Metastatic (Stage IV) Non-small Cell Lung Cancer.
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant
Status: NOT_YET_RECRUITING
Conditions: Myeloid Malignancy|Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of DelanzoᵀᴹDR 60mg (Dexlansoprazole) Capsule With Dexilant® 60mg (Dexlansoprazole) Capsule in Healthy Pakistani Subjects.
Status: COMPLETED
Conditions: Healthy|Bioequivalence Study
Interventions: DRUG: Dexlansoprazole|DRUG: Dexlansoprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses
Status: NOT_YET_RECRUITING
Conditions: Chronic Coronary Syndrome|Coronary Artery Disease|Ischemic Heart Disease
Interventions: DRUG: Adenosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor
Status: RECRUITING
Conditions: Advanced Liver Cancer
Interventions: DRUG: 60mg ABSK-011capsule|DRUG: 120mg ABSK-011capsule|DRUG: 180mg ABSK-011capsule|DRUG: 240mg ABSK-011capsule|DRUG: 320 mg ABSK-011capsule|DRUG: 400mg ABSK-011capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Filgotinib Effect on Proteomic Profile and Micro-RNA Expression in Patients With Active Rheumatoid Arthritis (RA)
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Filgotinib|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tacrolimus Sustained-release Capsules in Induction Treatment in Refractory Lupus Nephritis
Status: COMPLETED
Conditions: Nephritis, Lupus
Interventions: DRUG: Tacrolimus Sustained-release Capsules (ADVAGRAF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Fusion Biopsy of the Prostate
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: FACBC PET-CT Scan|PROCEDURE: Three-dimensional ultrasound-guided biopsy|PROCEDURE: Standard transrectal ultrasound (TRUS) guided biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer
Status: RECRUITING
Conditions: Frailty|Childhood Cancer
Interventions: DRUG: Dasatinib plus Quercetin|DRUG: Fisetin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen Plus Acetaminophen for Enhanced Pain Reduction
Status: UNKNOWN
Conditions: Pain, Acute
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sit-to-stand Training With Interactive Feedback in Chronic Stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Visual and auditory feedback STS training|OTHER: Conventional STS training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Lateral Wall Partial Rim-Sparing Orbital Decompression for Treatment of Thyroid-Related Orbitopathy
Status: COMPLETED
Conditions: Exophthalmos|Orbitopathy, Graves|Surgery
Interventions: PROCEDURE: Orbital decompression with ultrasonic bone removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of CER-001 on Plaque Volume in Homozygous Familial Hypercholesterolemia (HoFH) Subjects
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: CER-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 2 Doses of Solifenacin Succinate in Female Subjects With Overactive Bladder.
Status: COMPLETED
Conditions: Detrusor Overactivity|Overactive Bladder
Interventions: DRUG: Placebo|DRUG: solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Mechanically Ventilated ICU Patients
Status: COMPLETED
Conditions: Critical Illness
Interventions: DRUG: Sedation drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trial of Abiraterone Acetate Plus LHRH-therapy Versus Abiraterone Acetate Sparing LHRH-therapy in Patients With Progressive Chemotherapy-naïve Castration-resistant Prostate Cancer (SPARE)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: abiraterone acetate + prednisone + LHRH-therapy|DRUG: abiraterone acetate + prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Will Assess the Safety and Tolerability of AZD8418 After Single Increasing Oral Doses
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: AZD8418|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effectiveness of Vitamin D Supplementation in Patients With End-stage Knee Osteoarthritis
Status: RECRUITING
Conditions: Vitamin D Deficiency|Sarcopenia|Knee Osteoarthritis
Interventions: DRUG: Vitamin D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tomivosertib (eFT-508) in Combination With PD-1/PD-L1 Inhibitor Therapy
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Tomivosertib (eFT-508)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Status: NOT_YET_RECRUITING
Conditions: Major Depressive Disorder|Obsessive-Compulsive Disorder|Schizophrenia|Generalized Anxiety Disorder|Mood Disorders|Psychiatric Disorder|Mental Disorder|Depression, Anxiety
Interventions: DEVICE: TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study CLBG and Benzoyl Peroxide Gel 1%/5% to BenzaClin® Gel in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Clindamycin and Benzoyl Peroxide Gel 1%5%|DRUG: BenzaClin® Topical Gel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Deoxycholic Acid Injection (ATX-101) Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area
Status: COMPLETED
Conditions: Moderate or Severe Submental Fullness
Interventions: DRUG: Deoxycholic acid injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Toolbox Approach to Obesity Treatment in Primary Care
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Commercial weight loss program|BEHAVIORAL: Colorado Weigh|DIETARY_SUPPLEMENT: Meal replacements|DRUG: Obesity pharmacotherapy|BEHAVIORAL: Recreation center passes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
Status: RECRUITING
Conditions: End of Life|Cancer
Interventions: OTHER: Receive technology-based supportive cancer care|BEHAVIORAL: Receive redesigned team-based supportive cancer care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SKB264 Injection vs Investigator Selected Regimens to Treat Locally Advanced, Recurrent or Metastatic Triple-negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: SKB264
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of rhBMP-2/BCP in Patients With Spinal Degeneration With Instability Requiring Surgical Fusion
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: rhBMP-2/BCP device|DEVICE: rhBMP-2/BCP device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Transdermal Testosterone for Low Libido in Pre and Postmenopausal Women
Status: COMPLETED
Conditions: Sex Behavior
Interventions: DRUG: Biolipid B2 (blanked/placebo)|DRUG: Testosterone, Transdermal, Behavior
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lunch is in the Bag: Helping Parents Increase Fruit, Vegetables, and Whole Grains in Preschool Sack Lunches
Status: COMPLETED
Conditions: Dietary Behavior
Interventions: BEHAVIORAL: Lunch is in the Bag behavioral intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial of JYB1904 in Chronic Spontaneous Urticaria.
Status: NOT_YET_RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: JYB1904|DRUG: JYB1904|DRUG: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Gut Microbiota by Probiotic in Children
Status: RECRUITING
Conditions: Generally Healthy
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Surface EMG Activity After Dry Needling Compared to Sham Needling
Status: COMPLETED
Conditions: Neck Pain, Posterior|Work-Related Condition
Interventions: OTHER: Dry needling|OTHER: Sham needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment of Temporomandibular Disorders in Children and Adolsecents
Status: RECRUITING
Conditions: Temporomandibular Disorder|Myalgia|Arthralgia of TMJ
Interventions: DEVICE: Soft occlusal appliance|BEHAVIORAL: Jaw exercises|BEHAVIORAL: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intravenous Infusions of Gut Hormones on Appetite and Metabolism.
Status: COMPLETED
Conditions: Obesity
Interventions: BIOLOGICAL: PYY 3-36|BIOLOGICAL: GLP-1|BIOLOGICAL: saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HIV Attachment Inhibitor to Treat Human Immunodeficiency Virus 1 (HIV-1) Infections
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: BMS-663068 400 mg|DRUG: BMS-663068 800 mg|DRUG: BMS-663068 600 mg|DRUG: BMS-663068 1200 mg|DRUG: Raltegravir 400 mg|DRUG: Tenofovir 300 mg|DRUG: Ritonavir 100 mg|DRUG: Atazanavir 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Versus Moderate Muscle Relaxation During Laparoscopic Donor Nephrectomy in Enhancing Postoperative Recovery
Status: COMPLETED
Conditions: Neuromuscular Block|Renal Transplant Donor of Left Kidney|Renal Transplant Donor of Right Kidney|Surgery
Interventions: OTHER: Rocuronium|OTHER: No additional Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Program Based in High Intensity Interval Training and Dietary Education for Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Dietary and physiotherapy|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept, Calcium Aluminosilicate Anti-Diarrheal (CASAD) for Treatment of Clostridium Difficile Infection
Status: TERMINATED
Conditions: Diarrhoea, Clostridium Difficile
Interventions: DRUG: Calcium Aluminosilicate Anti-Diarrheal (CASAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Elective Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy|Colon Polyps
Interventions: DRUG: fospropofol disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: gemtuzumab ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Mass Balance, and Metabolism of [14C]HSK21542 in Healthy Adult Male Volunteers.
Status: COMPLETED
Conditions: Peripheral Analgesic and Anti-itch
Interventions: DRUG: [14C]HSK21542
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
Status: COMPLETED
Conditions: Cerebrovascular Stroke|Large-Artery Atherosclerosis (Embolus/Thrombosis)|Intracranial Arteriosclerosis
Interventions: DRUG: BT200|DRUG: Desmopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib (Velcade) Post Allogenic Peripheral Blood Stem Cell Transplantation for Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate Safety and Efficacy of Hyperthermic Intra-peritoneal Chemotherapy (HIPEC) With Mitomycin C Used During Surgery for Treatment of Locally Advanced Colorectal Carcinoma
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: MITOMYCIN-C 30 mg|PROCEDURE: Proactive cytoreductive surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serum Biomarker Levels Improvement in Poly Cystic Ovarian Syndrome: Impact of Metformin Compared to Healthy Controls
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome|Insulin Resistance
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pancreatic Enzyme Supplementation in Patients With Unresectable Pancreatic Cancer (PESUP)
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Norzyme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent|High Risk for Cardiovascular Event
Interventions: DRUG: Dapagliflozin 10 mg|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow-up and Outcome of Operative Treatment With Decompressive Release Of The Peroneal Nerve
Status: RECRUITING
Conditions: Peroneal Nerve Entrapment
Interventions: PROCEDURE: Neurolysis peroneal nerve|OTHER: Maximal physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetics and Safety Study of Narfurine Hydrochloride Orally Disintegrating Tablets
Status: UNKNOWN
Conditions: Improvement of Pruritus in Hemodialysis Patients
Interventions: DRUG: narfurine hydrochloride orally disintegrating tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response to PNEUMOVAX 23 in Healthy Adults Receiving Efgartigimod IV
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Efgartigimod|OTHER: Placebo|BIOLOGICAL: PNEUMOVAX 23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics, Safety, and Tolerability of CSL760, an Intravenous Anti-SARS-CoV-2 Hyperimmune Globulin, in Healthy Adult Subjects
Status: TERMINATED
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: BIOLOGICAL: CSL760
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Study to Compare the Efficacy and Safety of HLX10 in Combination With HLX04 Versus Sorafenib as the First-line Treatment in Patients With Locally Advanced or Metastatic HCC
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: DRUG: HLX10|DRUG: HLX04|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asthma in the Elderly: The Effect of Montelukast
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast 10 mg orally|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of Escalating Single Doses of TAK-828 in Healthy Participants
Status: COMPLETED
Conditions: Dose Finding Study
Interventions: DRUG: TAK-828|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Caregiver Enhanced Assistance and Support for the Elderly Heart Failure Patient at Hospital Discharge (CEASE-HF)
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Standardized Heart Failure Discharge Summary to Primary Care Physicians©|BEHAVIORAL: Standardized education sessions|OTHER: Heart Failure Diuretic Decision Support Tool for Patient Self Management©|OTHER: Digital talking scale|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
Status: RECRUITING
Conditions: Impaired Cognition|Chemo-brain|Breast Cancer
Interventions: OTHER: Cognitive, functional and subjective assessments|DEVICE: MRI|RADIATION: PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Is the Measured Diameter of the Optic Nerve Sheath by Cerebral Scan in Patients With Early-phase Meningeal Hemorrhage, Due to a Ruptured Aneurysm, a Prognostic 6-month Mortality Factor ?
Status: UNKNOWN
Conditions: Subarachnoid Hemorrhage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DNX-2440 Oncolytic Adenovirus for Recurrent Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma|Glioblastoma, Adult
Interventions: DRUG: DNX-2440 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dial-Bicarb Trial: Effects of a Lower vs. Higher Concentration of Dialysate Bicarbonate
Status: NOT_YET_RECRUITING
Conditions: Hemolysis|Renal Failure
Interventions: OTHER: Bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemented Hemiarthroplasty Versus Uncemented Furlong Hemiarthroplasty
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DEVICE: Uncemented Furlong Hemiarthroplasty|DEVICE: Cemented tapered stem hemiarthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Risk and Severity of IRRs in Patients Premedicated With Cetirizine vs. Diphenhydramine Prior to Ocrelizumab
Status: COMPLETED
Conditions: Multiple Sclerosis|Infusion Reaction
Interventions: DRUG: cetrizine|DRUG: diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AKTIIA OBPM to Assess CPAP Effect on Blood Pressure in Obstructive Sleep Apnea
Status: NOT_YET_RECRUITING
Conditions: Hypertension|Cardiac Function and Hemodynamics|Usability|Patient Experience
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concomitant Utilization of Radio Frequency Energy for Atrial Fibrillation (CURE-AF) Study
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Cardioblate System Surgical Ablation System|PROCEDURE: Surgical RF Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bucillamine in Treatment of Patients With COVID-19
Status: TERMINATED
Conditions: Covid19
Interventions: DRUG: Bucillamine|DRUG: Placebo|DRUG: Bucillamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neurophysiological Facilitation Techniques on Respiratory in Stroke
Status: COMPLETED
Conditions: Hemiplegia,Stroke, Respiratory, Neurophysiological Facilitation Techniques
Interventions: OTHER: Neurophysiological Facilitation Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Resistance Exercise for Glycemic Control in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Resistance Exercise Training Program With Rubber Bands
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature Infants
Status: RECRUITING
Conditions: Necrotizing Enterocolitis|Premature Birth
Interventions: BIOLOGICAL: premature newborns developing a NEC|BIOLOGICAL: premature newborns without NEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Immunogenicity of IVX-A12 in Healthy Older Adults
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: IVX-121|BIOLOGICAL: IVX-241|BIOLOGICAL: Placebo|BIOLOGICAL: IVX-121|BIOLOGICAL: IVX-241|BIOLOGICAL: IVX-241|BIOLOGICAL: IVX-121|BIOLOGICAL: IVX-241|BIOLOGICAL: IVX-241|OTHER: MF59®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Cervical Intraepithelial Neoplasm (CIN) in Women (Gardasil) (V501-015)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer|Genital Warts
Interventions: BIOLOGICAL: Gardasil, human papillomavirus (type 6, 11, 16, 18) recombinant vaccine|BIOLOGICAL: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fisetin to Improve Vascular Function in Older Adults
Status: RECRUITING
Conditions: Aging|Endothelial Dysfunction|Arterial Stiffness
Interventions: DIETARY_SUPPLEMENT: Fisetin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Spinal Cord Injuries With (AutoBM-MSCs)vs (WJ-MSCs).
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BIOLOGICAL: Collection and expansion of BM-MSC|DIAGNOSTIC_TEST: VI-SCI evaluation and patients' follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online-Delivered Comprehensive Behavioral Intervention for Tics-Enhanced (CBIT-E)
Status: UNKNOWN
Conditions: Persistent Tic Disorders|Tourette Disorder
Interventions: BEHAVIORAL: Comprehensive Behavioral Intervention for Tics - Enhanced (CBIT-E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Comparing a Biosimilar Eptacog Alfa With Novoseven, in Patients With Hemophilia With Inhibitors
Status: COMPLETED
Conditions: Hemophilia A or B With Inhibitor
Interventions: BIOLOGICAL: Biosimilar eptacog alfa, activated (AryoSeven)|BIOLOGICAL: Eptacog alfa, activated (Novoseven)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Migration and Bone Density Study Comparing Hi-Fatigue Bone Cement and Palacos Bone Cement
Status: COMPLETED
Conditions: Hip Arthritis
Interventions: DEVICE: Hi-Fatigue Bone Cement|DEVICE: Palacos Bone Cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Future Cardia™ Insertable Cardiac Monitor in Subjects With Paroxysmal Atrial Fibrillation (First-in-Human Study)
Status: RECRUITING
Conditions: Arrhythmias, Cardiac|Atrial Fibrillation|Bradycardia|Ventricular Tachycardia|Asystole
Interventions: DEVICE: Future Cardia™ Insertable Cardiac Monitoring (ICM) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Hodgkin Disease|Allogeneic Stem Cell Transplantation
Interventions: DIAGNOSTIC_TEST: Low-field magnetic resonance imaging|DIAGNOSTIC_TEST: Cardiopulmonary testing|DIAGNOSTIC_TEST: Pulmonary testing|DIAGNOSTIC_TEST: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Finger Individuation Training With a Training Device Versus Conventional Rehabilitation for Writer's Cramp
Status: TERMINATED
Conditions: Dystonic Disorders
Interventions: DEVICE: Finger Force Manipulandum|OTHER: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Suggestive Effects on the Diameter of Coronary Arteries
Status: COMPLETED
Conditions: Coronary Circulation
Interventions: BEHAVIORAL: Verbal suggestions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM
Status: COMPLETED
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: Valsartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area in Subjects 65 to 75 Years of Age
Status: COMPLETED
Conditions: Moderate to Severe Convexity of Submental Fat|Safety|Efficacy
Interventions: DRUG: ATX-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fascia Iliaca Block for Anesthesia in Lower Limb Thromboembolectomy
Status: COMPLETED
Conditions: Chronic Lower Limb Ischemia
Interventions: DRUG: Fascia iliaca block (FIB)|OTHER: Spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of TER-101 Topical Ointment in Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: TER-101|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Infant Massage on Acceptance, Commitment and Conscience of Influence of Parents With Down Syndrome Babies
Status: COMPLETED
Conditions: Parent-Child Relations
Interventions: OTHER: Infant Massage course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics
Status: RECRUITING
Conditions: Thiazide Associated Hyponatremia
Interventions: OTHER: Standard Care|OTHER: aSID/ChU Guided Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001)
Status: COMPLETED
Conditions: Heart Failure|Chronic Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Vericiguat|DRUG: Placebo for vericiguat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan/Cetuximab Followed by XELOX/Cetuximab vs the Reverse Sequence in Metastatic CRC
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: Irinotecan|DRUG: Capecitabine|DRUG: Cetuximab|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lactium on Sleep Disorders in Healthy Volunteers With Persistent Subclinical Insomnia
Status: NOT_YET_RECRUITING
Conditions: Sleep Disorder
Interventions: DIETARY_SUPPLEMENT: Lactium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Adjunctive Treatment to Antidepressant Therapy for Adults With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: LY2216684|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety, Efficacy of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3007
Status: COMPLETED
Conditions: Osteoarthritis|Pain
Interventions: DRUG: Placebo|DRUG: Fulranumab 1 mg|DRUG: Fulranumab 3 mg|DRUG: Celecoxib 100 mg|DRUG: Celecoxib 100 mg Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Norwegian Antibiotics for Pneumonia in Children Study
Status: UNKNOWN
Conditions: Pneumonia Childhood|Lower Respiratory Tract Infection
Interventions: DRUG: Amoxicillin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Reviewing Medical Records to Learn More About Treat-and-extend With Eylea in Patients With Neovascular Age-related Macular Degeneration (nAMD).
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Study of CyberKnife Radiosurgery Delivered to the Partial Breast
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: RADIATION: CyberKnife Partial Breast Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Theraflu Day Powder as Oral Solution for Cold and Flu
Status: WITHDRAWN
Conditions: Infections, Respiratory Tract
Interventions: DRUG: Paracetamol, phenylephrine HCl, and vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ultrasound-guided Erector Spinae Block on Postoperative in Patients Undergoing Nephrectomy.
Status: COMPLETED
Conditions: Nephrectomy
Interventions: PROCEDURE: erector spinae block (ESP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Umbrella, Modular Study Based on Epidermal Growth Factor Receptor (EGFR) Mutation Status
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Erlotinib Hydrochloride (Tarceva)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotic, Prebiotic and Synbiotic Effect on Immunity
Status: UNKNOWN
Conditions: Dietary Intervention
Interventions: DIETARY_SUPPLEMENT: probiotic|DIETARY_SUPPLEMENT: prebiotic|DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Panobinostat Adult Patients DLBCL Relapsed/Refractory Stem Cell Transfusion (ASCT) or Not Eligible for ASCT
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Panobinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation
Status: UNKNOWN
Conditions: Thrombocytopenia
Interventions: DRUG: Carica Papaya Leaf Extract|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SMAC Mimetic LCL161 Alone or With Cyclophosphamide in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|OTHER: Quality-of-Life Assessment|DRUG: Smac Mimetic LCL161
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aloe Vera on Irradiated Breast Tissue
Status: COMPLETED
Conditions: Irradiated Breast Tissue
Interventions: OTHER: Klean & Klear The Dandy Day Corp|OTHER: The Skin Gel Herbal Answers, Inc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Exoskeleton Impact on the Quality of Life on Patients With Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Spinal Muscular Atrophy Type II
Interventions: DEVICE: Use of the ATLAS 2025 exoskeleton at home
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study to Assess Safety, Tolerability and Pharmacokinetics of OP0595
Status: COMPLETED
Conditions: Healthy Volunteers|Bacterial Infections
Interventions: DRUG: OP0595|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Determining How Indoor Lighting Affects the Brain Health of Older Adults
Status: RECRUITING
Conditions: Sleep|Physical Activity|Cognitive Function|Social Isolation
Interventions: BEHAVIORAL: Static Lighting Condition (L1)|BEHAVIORAL: Dynamic Lighting Condition (L2)|BEHAVIORAL: Dynamic Lighting Condition (L3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TMHT - Difficult Intubation Prediction Using Double Lumen Video Tubes
Status: COMPLETED
Conditions: Predictive Value of Tests|Intubation;Difficult
Interventions: DEVICE: Double Lumen Endotracheal Tube.|DEVICE: Double Lumen Video Endotracheal Tube.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Repair Versus Non-repair of the Aortic Arch in Type A Aortic Dissection (TAAD)
Status: ENROLLING_BY_INVITATION
Conditions: Aortic Dissection|Aortic Arch|Aortic Dissection Rupture|Aortic Dilatation
Interventions: PROCEDURE: Conservative TAAD-R|PROCEDURE: Extensive TAAD- R
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Korean Red Ginseng on Insulin Sensitivity in Non Diabetic Overweight Korean Adults
Status: COMPLETED
Conditions: Insulin Resistance|Obesity
Interventions: OTHER: Korea red ginseng|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Mild to Moderate Pneumonia in Adult Patients
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: azithromycin sustained release|OTHER: placebo|DRUG: levofloxacin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glin3: Assessment of the Glycemic Responses to Nutritional Products
Status: COMPLETED
Conditions: Glycemic Response
Interventions: DIETARY_SUPPLEMENT: first reference product series 1|DIETARY_SUPPLEMENT: second reference product seies 1|DIETARY_SUPPLEMENT: third reference product series 1|DIETARY_SUPPLEMENT: first concept product series 1|DIETARY_SUPPLEMENT: second concept product series 1|DIETARY_SUPPLEMENT: third concept product series 1|DIETARY_SUPPLEMENT: 4th concept product seris 1|DIETARY_SUPPLEMENT: 5th concept product series 1|DIETARY_SUPPLEMENT: 6th concept product series 1|DIETARY_SUPPLEMENT: 1st reference product series 2|DIETARY_SUPPLEMENT: 2nd reference product series 2|DIETARY_SUPPLEMENT: 3rd reference product series 2|DIETARY_SUPPLEMENT: 1st concept product series 2|DIETARY_SUPPLEMENT: 2nd concept product series 2|DIETARY_SUPPLEMENT: 3rd concept product series 2|DIETARY_SUPPLEMENT: 4th concept product series 2|DIETARY_SUPPLEMENT: 5th concept product series 2|DIETARY_SUPPLEMENT: 6th concept product series 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Attentional Therapy on Post-traumatic Stress Disorder
Status: NOT_YET_RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Eye-tracking assisted attention control training (ACTo)|BEHAVIORAL: Attention control training (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
Status: RECRUITING
Conditions: Eosinophilic Granulomatosis With Polyangiitis
Interventions: BIOLOGICAL: Depemokimab|BIOLOGICAL: Mepolizumab|DRUG: Placebo matching mepolizumab|DRUG: Placebo matching depemokimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT