pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase I Study of Adenoviral Vector Mediated Gene Transfer for Ornithine Transcarbamylase in Adults With Partial Ornithine Transcarbamylase Deficiency
Status: TERMINATED
Conditions: Ornithine Transcarbamylase Deficiency Disease
Interventions: GENETIC: Adenoviral Vector-Mediated Gene Transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Motor Neurological Soft Signs (MNSS) in Persons With Schizophrenia
Status: COMPLETED
Conditions: Psychomotor Status|Schizophrenia|Motor Skills Disorders
Interventions: DIAGNOSTIC_TEST: Brief Motor Scale_portuguese version (BMS_pt)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Domiciliary VR Rehabilitation
Status: COMPLETED
Conditions: Hemiparesis|Functional Independence|Movement Disorder|Stroke
Interventions: BEHAVIORAL: Domiciliary VR-based motor rehabilitation|BEHAVIORAL: Domiciliary occupational therapy for motor rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Clopidogrel|DRUG: Prasugrel|DRUG: Commercially-available Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Recurrent Lung Non-Small Cell Carcinoma|Stage II Non-Small Cell Lung Cancer AJCC v7|Stage IIA Non-Small Cell Lung Carcinoma AJCC v7|Stage IIB Non-Small Cell Lung Carcinoma AJCC v7|Stage IIIA Non-Small Cell Lung Cancer AJCC v7|Stage IIIB Lung Non-Small Cell Cancer AJCC v7
Interventions: RADIATION: Image Guided Radiation Therapy|RADIATION: Image Guided Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|RADIATION: Photon Beam Radiation Therapy|RADIATION: Proton Beam Radiation Therapy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 CoronaVac in Patients With Autoimmune Rheumatic Diseases and HIV/AIDS
Status: COMPLETED
Conditions: Rheumatic Disease|HIV Infections|AIDS|Safety Issues|Immunogenicity|COVID-19
Interventions: BIOLOGICAL: CoronaVac
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal
Interventions: BIOLOGICAL: Short ragweed pollen allergen extract|BIOLOGICAL: Placebo|DRUG: Self-injectable epinephrine|DRUG: Albuterol/Salbutamol|DRUG: Loratadine|DRUG: Olopatadine|DRUG: Mometasone furoate monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Reduction for Urban Substance Using Men Who Have Sex With Men (MSM)
Status: COMPLETED
Conditions: HIV Infection|Substance Abuse
Interventions: BEHAVIORAL: empowerment theory-based small group discussion|BEHAVIORAL: individual resilience counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Oral Combined Berberine and Curcumin Pharmacological Therapy on IBS
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: A combined supplement of Berberine and Curcumin (Enterophytol® PLUS) alongside standard of care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Right Apical Versus Septal Pacing Trial
Status: UNKNOWN
Conditions: Heart Block|Heart Failure
Interventions: DEVICE: Apical RV lead placement|DEVICE: Septal RV lead placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Morphine vs Sufentanil PCA: Same Same or Different?
Status: COMPLETED
Conditions: Analgesia|Post Operative Pain|Patient Satisfaction|Chronic Pain
Interventions: DRUG: Sufentanil Sublingual Tablet System|DRUG: Intravenous Patient-Controlled Analgesia with morfine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Lower Intraabdominal Pressure on Syndecan-1, sVEGF-R2, Occludin, KIM-1, and IL-6 on Living Donor Laparoscopic Nephrectomy
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Pneumoperitoneum pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Chronic Effects of Beetroot Juice in Hypertensive Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: beetroot juice|DIETARY_SUPPLEMENT: Nitrate-free beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation
Status: COMPLETED
Conditions: Uncontrolled Hypertension|Atrial Fibrillation
Interventions: DEVICE: Boston Scientific Vessix Renal Denervation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology
Status: COMPLETED
Conditions: Post-Concussion Syndrome|Post-Traumatic Headache|Post-Concussive Syndrome, Chronic|Head Injury|MTBI - Mild Traumatic Brain Injury|Acquired Brain Injury|Closed Head Injury
Interventions: BEHAVIORAL: Exercise+CT|BEHAVIORAL: Exercise only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate and Compare the Efficacy and Safety of FK506MR vs Prograf® in Stable Liver Transplantation Patients
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: Prograf|DRUG: FK506MR capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Level of Immersion of Virtual Reality and Cognition and Motor Performance in Patients of Schizophrenia Spectrum Disorder
Status: COMPLETED
Conditions: Schizophrenia|Virtual Reality|Video Games|Multi-tasks
Interventions: BEHAVIORAL: multi-task in the real world and virtual reality video sport games
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of SQZ-eAPC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Adult Solid Tumor
Interventions: BIOLOGICAL: SQZ-eAPC-HPV|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2PX (Topical Strontium Chloride Hexahydrate) in Patients With Post-Amputation Stump Pain.
Status: COMPLETED
Conditions: Amputation Stumps|Pain
Interventions: DRUG: Strontium chloride hexahydrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Molecular Weight Heparin: Tinzaparin in Lung Tumours (TILT)
Status: COMPLETED
Conditions: Lung Cancer|Non Small Cell Lung Cancer
Interventions: DRUG: Tinzaparin sodium 100 UI/Kg/OD for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pramipexole Compared to Placebo in the Treatment of Restless Legs Syndrome (RLS)
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Pramipexole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Multifidus Cervicis and Inter-Semispinal Plane Blocks in Analgesia After Cervical Spine Surgery
Status: RECRUITING
Conditions: Cervical Spine Surgery
Interventions: PROCEDURE: control group|PROCEDURE: MCP group|PROCEDURE: ISP group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoporosis|Osteoarthritis
Interventions: OTHER: Ballistic Resistance Lower Body Strength Training|OTHER: Conventional Resistance Lower Body Strength Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy Of Muscle Energy Technique On Shoulder Adhesive Capsulitis Post Mastectomy
Status: UNKNOWN
Conditions: Adhesive Capsulitis of Shoulder
Interventions: BEHAVIORAL: muscle energy technique|BEHAVIORAL: conventional physical therapy program (Mobilization exercises, Posterior capsule stretching, and Range of motion exercises) 1 session per day, 5 days a week for 8 weeks.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) Utilizing Ultrasound and Percutaneous Liver Biopsy
Status: COMPLETED
Conditions: Fatty Liver
Interventions: PROCEDURE: possible liver biopsy and serum collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients
Status: COMPLETED
Conditions: General Surgery With Endotracheal Intubation
Interventions: DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Transcatheter Tricuspid Annular Repair
Status: UNKNOWN
Conditions: Tricuspid Regurgitation
Interventions: DEVICE: MIA, Minimally Invasive Annuloplasty Device - Surgical|DEVICE: MIA, Minimally Invasive Annuloplasty Device - Percutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A in Treatment of Cranial Allodynia in Patients With Headache
Status: COMPLETED
Conditions: Headache|Allodynia
Interventions: DRUG: Botulinum toxin type A|DRUG: 0,9% saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Two Concentrations of DFD-07 Cream, in Subjects With Actinic Keratosis (AK) of the Face and/or Scalp Over a 12-week Treatment Period
Status: COMPLETED
Conditions: Actinic Keratosis (AK)
Interventions: DRUG: Low dose DFD07 once daily|DRUG: High dose DFD07 once daily|DRUG: High dose DFD07 twice daily|DRUG: Placebo twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer
Status: TERMINATED
Conditions: Thyroid Cancer|Colon Cancer|Ovarian Cancer|Breast Cancer|Lung Cancer|Pancreatic Cancer
Interventions: BIOLOGICAL: ETBX-011|BIOLOGICAL: ALT-803
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial: IS Zinc and Zinc Ionophere EGCG as Supplement Improve Outcome of Active Pulmonary Tuberculosis
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: COMBINATION_PRODUCT: zinc 50 mg + Epigallocatechin gallate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized, Open Label, Phase II Study to Assess Efficacy and Safety of Macugen® (Pegaptanib 0.3 mg Intravitreal Injections) Plus Panretinal Photocoagulation and PRP (Monotherapy) in the Treatment With High Risk PDR.
Status: COMPLETED
Conditions: High Risk Proliferative Diabetic Retinopathy|Diabetes Mellitus Type I|Diabetes Mellitus Type II
Interventions: PROCEDURE: Panretinal Photocoagulation (PRP)|DRUG: Intravitreous injection of pegaptanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of VGR-R01 for Patients With Bietti Crystalline Dystrophy
Status: NOT_YET_RECRUITING
Conditions: Bietti Crystalline Dystrophy
Interventions: GENETIC: VGR-R01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Irinotecan With Concomitant FOLFOX and Bevacizumab
Status: RECRUITING
Conditions: Colorectal Cancer|Peritoneal Metastases
Interventions: DRUG: Irinotecan|DRUG: FOLFOX regimen|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin for Cramps in Diabetic Neuropathy
Status: COMPLETED
Conditions: Muscle Cramps Aggravated|Diabetes Mellitus
Interventions: DRUG: Botulinum toxin type A|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Field Shape and Amplitude Sensitivity Exploratory Study (CONTOUR Study)
Status: TERMINATED
Conditions: Chronic Neuropathic Pain in the Low Back and Legs
Interventions: DEVICE: Boston Scientific's Precision SPECTRA™ Spinal Cord Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Role Of Omega-3 Fatty Acids In Adolescent Depression
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Omega 3 Fatty Acids|DIETARY_SUPPLEMENT: Corn oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of mRNA-1283.222 Injection Compared With mRNA-1273.222 Injection in Participants ≥12 Years of Age to Prevent COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: mRNA-1283.222|BIOLOGICAL: mRNA-1273.222
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Effectiveness and Safety of Topiramate Monotherapy in Patients With Recently Diagnosed Partial-Onset Seizure
Status: COMPLETED
Conditions: Epilepsy|Epilepsies, Partial|Seizures
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Chart Review of Patients With COPD, Using Electronic Medical Records and Artificial Intelligence
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Factors associated with Hospital admission for an Acute Exacerbation Chronic Obstructive Pulmonary Disease (AECOPD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: E2006 1.0 mg|DRUG: E2006 2.5 mg|DRUG: E2006 5.0 mg|DRUG: E2006 10.0 mg|DRUG: E2006 25.0 mg|DRUG: E2006 50.0 mg|DRUG: E2006 100 mg|DRUG: E2006 200 mg|DRUG: Zolpidem 10 mg|DRUG: E2006 Matched Placebo or Zolpidem Matched Placebo|DRUG: E2006 Matched Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Elacestrant vs Elacestrant Plus a CDK4/6 Inhibitor in Patients With ERpositive/HER2-negative Advanced or Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Estrogen-receptor-positive Breast Cancer|HER2/Neu-Negative Breast Cancer|Advanced Breast Cancerv|Metastatic Breast Cancer
Interventions: DRUG: elacestrant, palbociclib, abemaciclib, ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POEM STUDY: A Phase IIa Trial in Endometrial Carcinoma With Temsirolimus
Status: COMPLETED
Conditions: Carcinoma, Endometrioid|mTOR Protein
Interventions: DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABBV-1088 Oral Dose in Healthy Adult Participants.
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Drug: ABBV-1088|DRUG: Drug: Placebo for ABBV-1088
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MesomiR 1: A Phase I Study of TargomiRs as 2nd or 3rd Line Treatment for Patients With Recurrent MPM and NSCLC
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma|Non-Small Cell Lung Cancer
Interventions: DRUG: TargomiRs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial
Status: UNKNOWN
Conditions: Oral Lichen Planus
Interventions: DRUG: Co-Enzyme Q10 mucoadhesive tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Validation of the Molecular-Based GenePOC Carba Assay for the Detection and Differentiation of Carbapenemase Genes in Rectal Swab Samples.
Status: UNKNOWN
Conditions: Carbapenem-Resistant Enterobacteriaceae
Interventions: DEVICE: Rectal swab collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Ethyl Eicosapentanoic Acid (Ethyl-EPA) for Treating Major Depression
Status: COMPLETED
Conditions: Depressive Disorder|Depression
Interventions: DRUG: Ethyl-eicosapentanoic acid (ethyl-EPA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: d68Ga-DOTATATE PET/CT Assessment of Cardiac Sarcoidosis
Status: COMPLETED
Conditions: Cardiac Sarcoidosis
Interventions: DRUG: 68Ga-DOTATATE PET/CT|DRUG: 18FDG PET/CT scan|DRUG: 13NH3 PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study on Rare Dermatological Infections Conducted at Three Major Reference Hospitals in Costa Rica.
Status: COMPLETED
Conditions: Sporotrichosis|Chromomycosis|Actinomycosis|Nocardiosis|Mycetoma|Mycobacterial Cutaneous Infection|Coccidioidomycosis|Blastomycosis|Paracoccidioidomycosis|Phaeomycosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subcu Administration of CD-NP in Heart Failure Patients With Left Ventricular Assist Device Support
Status: WITHDRAWN
Conditions: Heart Failure|Left Ventricular Assist Device|Natriuretic Peptide
Interventions: DRUG: CD-NP|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab, Hormone Therapy, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: bicalutamide|DRUG: goserelin acetate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EUS-guided Hepatico-gastrostomy Using a Novel Lumen Apposing Metal Stent
Status: RECRUITING
Conditions: Malignant Biliary Obstruction
Interventions: DEVICE: EUS-guided hepaticogastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind Placebo Control Opipramol-Baclofen Treatment for Addiction
Status: UNKNOWN
Conditions: Drug Abuse
Interventions: DRUG: Opipramol|DRUG: Baclofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: PD0332991 (Palbociclib) in Patients With Advanced or Metastatic Liposarcoma
Status: COMPLETED
Conditions: Sarcoma|Liposarcoma
Interventions: DRUG: Palbociclib 200mg|DRUG: Palbociclib 125mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Domestic Surgical Robot Clinical Study
Status: UNKNOWN
Conditions: Gastric Ulcer With Perforation But Without Obstruction|Colon Cancer|Cholecystolithiasis|Appendicitis|Sleeve Gastrectomy|Gastric Bypass|Gastric Cancer|Rectal Cancer
Interventions: PROCEDURE: Micro Hand S robotic surgery|PROCEDURE: laparoscopic surgery|PROCEDURE: da Vinci robotic surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy Trial to Examine Efficacy of Multimicronutrient Home Supplementation in Infants
Status: COMPLETED
Conditions: Iron Deficiency Anemia|Infectious Diseases|Undernutrition
Interventions: DIETARY_SUPPLEMENT: Sprinkles|DIETARY_SUPPLEMENT: Ferripel-3, Vitamins A&D drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: UFUR (Tegafur/Uracil) Plus Iressa in Non-small-cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: UFUR and Iressa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of Nemonoxacin Malate Capsules in Subjects With Moderate Impaired Hepatic Function
Status: COMPLETED
Conditions: Liver Dysfunction
Interventions: DRUG: Nemonoxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: LIFE-Lung Bronchoscopy in Patients at Risk for Developing Lung Cancer
Status: TERMINATED
Conditions: Non-Small-Cell Lung Carcinoma|Head and Neck Squamous Cell Cancer|Pulmonary Disease, Chronic Obstructive
Interventions: PROCEDURE: LIFE Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC
Status: COMPLETED
Conditions: Cholestatic Liver Disease
Interventions: DRUG: tauroursodeoxycholic|DRUG: ursodeoxycholic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TEPEZZA® (Teprotumumab-trbw) Post-Marketing Requirement Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Thyroid Eye Disease
Interventions: DRUG: Teprotumumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Safety, Tolerability, and Drug Levels in Blood After Single and Multiple Doses of LEO 32731 in Healthy People
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LEO 32731 modified release tablet|DRUG: LEO 32731 blend, hard capsule|DRUG: LEO 32731 API, hard capsule|DRUG: LEO 32731 soft capsule|DRUG: LEO 32731 gastro-resistant capsule|DRUG: LEO 32731|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study With Abediterol Administered Via Three Different Inhalation Devices in Healthy Volunteers.
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Abediterol (2.4 μg)|DRUG: Abediterol (4.8 μg)|DRUG: Abediterol (2.4 μg)|DRUG: Abediterol (2.5 μg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Cerebral Blood Flow and Cerebral Oxygenation With Transcranial Doppler and NIRS in Laparoscopic Cholecystectomy Cases
Status: RECRUITING
Conditions: Cerebral Hypoperfusion|Cerebral Occlusion|Cholecystitis; Gallstone|Cholecystitis/Cholelithiasis
Interventions: DEVICE: Near Infrared Spectrophotometry Device, Transcranial Doppler Ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Can Ammonium Inhalants Maintain Performance in Sleep Deprived Soldiers?
Status: COMPLETED
Conditions: Sleep Deprivation|Military Activity|Sleep|Cognitive Change|Military Combat Stress Reaction
Interventions: DRUG: Ammonia Inhalant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease|Coronary Atherosclerosis|Nicotine Dependence
Interventions: BEHAVIORAL: heated tobacco - lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of a Multi-Ingredient Pre-Workout Supplement on Energy Expenditure During Running
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: One dose pre-workout condition|DIETARY_SUPPLEMENT: Two dose pre-workout condition|DIETARY_SUPPLEMENT: Placebo condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study Evaluating CB-5083 in Subjects With Lymphoid Hematological Malignancies
Status: TERMINATED
Conditions: Lymphoid Hematological Malignancies|Relapsed and Refractory Multiple Myeloma
Interventions: DRUG: CB-5083|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Suture Technique on Wound Healing in Ankle Fracture Surgery: A Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Ankle Fractures
Interventions: PROCEDURE: Simple Interrupted Suture|PROCEDURE: Subcuticular Suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Post-Prostatectomy Incontinence Home Telehealth Program
Status: COMPLETED
Conditions: Urinary Incontinence|Prostate Cancer
Interventions: BEHAVIORAL: Pelvic Floor Muscle Training|BEHAVIORAL: Perioperative Care and Wetness Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Status: RECRUITING
Conditions: Continuous Glucose Monitoring|Oral Glucose Tolerance|Insulin Sensitivity|Inflammatory Markers
Interventions: OTHER: Non-Nutritive Sweetener Intake and impact on glucose homeostasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transvaginal Detrusor Nerve Radiofrequency Ablation for Treatment of Overactive Bladder
Status: ENROLLING_BY_INVITATION
Conditions: Overactive Bladder Syndrome
Interventions: DEVICE: Device Morpheus8V
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Urinary Incontinence After Prostatectomy
Status: UNKNOWN
Conditions: Urinary Incontinence
Interventions: PROCEDURE: BioFeedback; Functional Electrical Stimulation; Pelvic Floor Muscle training exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RFS (Radiofrequency Stylet) - Radiofrequency Perforator Vein Treatment Study
Status: TERMINATED
Conditions: Venous Insufficiency
Interventions: DEVICE: RF Ablation (ClosureRFS Stylet)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitochondria and Chronic Kidney Disease
Status: COMPLETED
Conditions: Hemodialysis-Induced Symptom|Mitochondrial Diseases
Interventions: DRUG: Icatibant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ablation of Renal Masses Outcomes Registry (ARMOR): Ablation Procedure and Quality of Life Assessment
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cancer
Interventions: BEHAVIORAL: (EORTC QLQ-C30) questionnaire|BEHAVIORAL: EuroQol EQ-5D 7-item questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Outcomes and Routine Management of Adults With Chronic Lymphocytic Leukaemia Treated With Idelalisib and Rituximab in the United Kingdom (UK) and Ireland
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukaemia
Interventions: DRUG: Idelalisib|DRUG: Rituximab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Digital Mood-enhanced CBT-I to Improve Depressive Symptoms in Adolescents
Status: RECRUITING
Conditions: Insomnia|Depression|Adolescent
Interventions: BEHAVIORAL: Standard dCBT-I|BEHAVIORAL: Modified Mood enhanced CBT-I (M-dCBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health Outcomes of Recently Diagnosed Myelodysplastic Syndrome (MDS)/Chronic Myelomonocytic Leukemia (CMML) Patients Depending on Treatment Strategy (Wait and See, Support, Active Treatment)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Leukemia, Myelomonocytic, Chronic
Interventions: OTHER: Either Wait and See, or Supportive Treatment, or Active Treatment at physician discretion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Magnetic Stimulation Therapy for Treating Vascular Depression
Status: COMPLETED
Conditions: Depressive Disorder|Depression
Interventions: PROCEDURE: Repetitive transcranial magnetic stimulation (rTMS)|DRUG: Citalopram|PROCEDURE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Intravascular Lithotripsy System in Patients With Coronary Artery Calcification (VIGOUR)
Status: RECRUITING
Conditions: Coronary Artery Calcification
Interventions: DEVICE: Intravascular Lithotripsy System of Shanghai MicroPort Rhythm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC
Status: RECRUITING
Conditions: Metastatic Castrate-sensitive Prostate Cancer
Interventions: DRUG: Apalutamide|DRUG: Androgen-deprivation Therapy (ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symptom Management in Patients With Recurrent or Persistent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: UNKNOWN
Conditions: Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma|Psychological Impact of Cancer|Recurrent Ovarian Carcinoma
Interventions: OTHER: Communication Intervention|OTHER: Educational Intervention|OTHER: Internet-Based Intervention|PROCEDURE: Psychosocial Assessment and Care|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Omega-3 Supplementation and Behavior Problems
Status: COMPLETED
Conditions: Aggression|Antisocial Behavior|Antisocial Personality
Interventions: DIETARY_SUPPLEMENT: Omega-3 supplemented drink|DIETARY_SUPPLEMENT: Smartfish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous or Intermittent Extension of Adjuvant Pyrotinib for Invasive HER2-positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer Invasive
Interventions: DRUG: pyrotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vibrotactile Coordinated Reset (vCR) for the Treatment of Advanced Parkinson's Disease Patients Who Have Previously Received vCR Stimulation
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Vibrotactile coordinated reset (vCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of APL180
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: DRUG: APL180|DRUG: APL180|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vorinostat and Pegylated Liposomal Doxorubicin in Relapsed or Refractory Lymphomas
Status: TERMINATED
Conditions: Relapsed Lymphomas|Refractory Lymphomas
Interventions: DRUG: Vorinostat|DRUG: Pegylated Liposomal Doxorubicin (PLD), Doxil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Modified Vacuum-formed Retainers Versus Hawley Retainer
Status: UNKNOWN
Conditions: Orthodontic Retainers|Clinical Trial
Interventions: DEVICE: Modified vacuum-formed retainer covering the palete|DEVICE: Hawley retainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CMX001 in Post-transplant Patients With BK Virus Viruria
Status: COMPLETED
Conditions: Viruria
Interventions: DRUG: Placebo|DRUG: Brincidofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Magnesium on Post-spinal Fentanyl Induced Pruritus Incidence
Status: UNKNOWN
Conditions: Magnesium Infusion in Post-spinal Opioid Pruritis
Interventions: DRUG: IV infusion|DRUG: intrathecal fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Clinical Outcomes of DermACELL® With Integra® Bilayer Wound Matrix
Status: UNKNOWN
Conditions: Wounds|Chronic Wounds|Nonmalignant Condition
Interventions: DEVICE: DermACELL®|DEVICE: Integra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of FG-3019 in Participants With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: FG-3019
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Anti-Disease Activity of Oral Tosedostat (CHR-2797) in Elderly Subjects With Refractory or Relapsed AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|AML
Interventions: DRUG: Tosedostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops
Status: RECRUITING
Conditions: Xerophthalmia
Interventions: DRUG: NCP112|DRUG: NCP112 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery
Status: RECRUITING
Conditions: Chronic Knee Pain|Obesity, Morbid
Interventions: DEVICE: Photobiomodulation|OTHER: Standard Physiotherapy Tretament|DEVICE: Photobiomodulation Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Powered Seating Function Usage Among Veterans - Compliance and Coaching
Status: COMPLETED
Conditions: Use of Power Wheelchairs and Power Seat Functions
Interventions: OTHER: Instruction Group: Power seat function usage instruction- verbal and written instruction|OTHER: Instruction and Virtual Coach Group: Power seat function usage instruction- verbal, written, and virtual coach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Exercise & Tart Cherry Ingestion on Heat Acclimation and Gut Microbiome
Status: TERMINATED
Conditions: Heat Acclimation and Thermotolerance
Interventions: DIETARY_SUPPLEMENT: tart cherry juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Controlled Trial of Hyperbaric Oxygen in Patients Who Have Taken Bisphosphonates
Status: COMPLETED
Conditions: Osteonecrosis
Interventions: DEVICE: hyperbaric oxygen|DEVICE: non-treated control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SWS And Daytime Functioning in Chronic FatiguE Syndrome (SAFFE)
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome
Interventions: DRUG: Sodium Oxybate|OTHER: placebo (fresh potable water)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study To Examine The Effects Of PF-04958242 On Ketamine-Induced Cognitive Impairment In Healthy Volunteers
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-04958242|DRUG: Ketamine|DRUG: Placebo|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Strategy-confirming Study of BMS-955176 to Treat HIV-1 Infected Treatment-experienced Adults
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: BMS-955176|DRUG: Atazanavir (ATV)|DRUG: Ritonavir (RTV)|DRUG: Dolutegravir (DTG)|DRUG: Tenofovir (TDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Rheumatoid Arthritis (RA) Study Treating Signs and Symptoms of RA in People With RA & Receiving Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: AMG 719|DRUG: AGM 719|DRUG: AMG 719|DRUG: placebo to AMG 719
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Triple-targeted Cell Preparation Targeting CD19/CD20/CD22 in Patients With Relapsed/Refractory B-cell Acute Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphocytic Leukemia
Interventions: BIOLOGICAL: LCAR-AIO Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of YH23537 in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: YH23537|DRUG: Celecoxib|DRUG: YH23537 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diode Laser in Gingival Enlargement Related to Orthodontics
Status: UNKNOWN
Conditions: Gingival Overgrowth
Interventions: PROCEDURE: Laser gingivectomy|PROCEDURE: Laser gingivectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: C-mo System 1.0's Validation - Cough Monitoring
Status: RECRUITING
Conditions: Cough|Asthma|Chronic Obstructive Pulmonary Disease|Gastro Esophageal Reflux|Idiopathic Pulmonary Fibrosis
Interventions: DEVICE: C-mo System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Temozolomide and Topotecan in Treating Patients With Primary CNS Lymphoma
Status: WITHDRAWN
Conditions: Central Nervous System Tumors|Lymphoma
Interventions: DRUG: temozolomide|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Over-the-counter Toothpastes on Enamel Remineralization
Status: UNKNOWN
Conditions: Enamel Caries
Interventions: DRUG: Sensodyne repair and protect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: INVESTIGATION AND COMPARISON OF THE EFFECTS OF POSTURE EXERCISES ON DYSFUNCTION, POSTURE AND BALANCE IN INDIVIDUALS WITH POSTERIOR EDENTULOUS AND FULL-TOOTHED TEMPOROMANDIBULAR DISORDER
Status: COMPLETED
Conditions: Temporomandibular Disorder
Interventions: OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxalate Formation From Ascorbic Acid
Status: RECRUITING
Conditions: Kidney Stone
Interventions: DIETARY_SUPPLEMENT: Low Oxalate Diet|DIETARY_SUPPLEMENT: Carbon-13 Ascorbic Acid Oral Load
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fluorouracil and Leucovorin With or Without Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Stress Hydrocortisone In Pediatric Septic Shock
Status: RECRUITING
Conditions: Septic Shock
Interventions: DRUG: Hydrocortisone, sodium succinate|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sofusa System With Sumatriptan (KC5010) Phase 1 Dose Escalation Safety and PK Study (KCC-SMT-002)
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: Sumatriptan Succinate Oral Tablet|COMBINATION_PRODUCT: Transdermal delivery of sumatriptan succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daily Liraglutide for Nicotine Dependence
Status: COMPLETED
Conditions: Smoking Cessation|Weight, Body
Interventions: DRUG: Liraglutide|DRUG: Placebo|BEHAVIORAL: Smoking Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT