pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Rehabilitation in Operation for Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer|Non Small Cell Lung Cancer
Interventions: BEHAVIORAL: Experimental: 1. Experimental|BEHAVIORAL: Experimental: 2. Experimental|BEHAVIORAL: Experimental: 3. Experimental|BEHAVIORAL: Other: 4. Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Improvement With Aripiprazole (Abilify) in Patients With Schizophrenia (SFBRI)
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Turmeric as Treatment in Epilepsy
Status: WITHDRAWN
Conditions: Epilepsy|Dravet Syndrome|Lennox-Gastaut Syndrome|Tuberous Sclerosis|Focal Seizures
Interventions: DIETARY_SUPPLEMENT: Turmeric
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PDE5 Inhibition Via Tadalafil to Enhance Anti-Tumor Mucin 1 (MUC1) Vaccine Efficacy in Patients With HNSCC
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Head and Neck Cancer
Interventions: DRUG: Tadalafil|BIOLOGICAL: Anti-MUC1 Vaccine|BIOLOGICAL: Anti-Influenza Vaccine|OTHER: Tadalafil Placebo|OTHER: Anti-MUC1 Vaccine Placebo|OTHER: Standard of Care Treatment|OTHER: Anti-Influenza Vaccine Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine (Fludara®) Plus Alemtuzumab (CAMPATH®, MabCampath®) vs Fludarabine Alone in B-Cell Chronic Lymphocytic Leukemia (B-CLL) Patients
Status: COMPLETED
Conditions: B-Cell Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: FluCAM [Fludara + Campath]|BIOLOGICAL: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Cruciate Ligament Reconstruction With and Without Lateral Extra-Articular Tenodesis Among High Demand Patients
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Tear
Interventions: PROCEDURE: Isolated anterior cruciate ligament reconstruction with lateral extra articular tenodesis|PROCEDURE: Isolated anterior cruciate ligament reconstruction only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: How to Reduce Suicidal Thoughts and Impulsivity in Depression
Status: RECRUITING
Conditions: Unipolar Depression|Impulsive Behavior|Suicidal Ideation
Interventions: DEVICE: active tDCS stimulating left DLPFC|DEVICE: active tDCS stimulating right OFC|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of GSK2132231A Antigen-Specific Cancer Immunotherapeutic in Patients With Inoperable Metastatic Cutaneous Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Immunotherapeutic GSK2132231A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
Status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Neoplasms|Uterine Cervical Neoplasms|Biliary Tract Neoplasms|Urologic Neoplasms|Carcinoma, Non-Small-Cell Lung|HER2 Mutations Breast Neoplasms
Interventions: DRUG: tucatinib|DRUG: trastuzumab|DRUG: fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VATS Block for Uniportal Video-assisted Thoracoscopic Surgery
Status: UNKNOWN
Conditions: Efficacy and Safety of VATS Block
Interventions: PROCEDURE: VATS|DRUG: Ropivacaine|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Potential Efficacy, and Pharmacokinetics of PZ-601 in the Treatment of Complicated Skin and Skin Structure Infection
Status: COMPLETED
Conditions: Skin Infections
Interventions: DRUG: PZ-601|DRUG: PZ-601|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Seltorexant High Dose|DRUG: Seltorexant Low Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic (PK) and Safety Study of Iptacopan (LNP023) in Participants With Mild, Moderate, and Severe Hepatic Impairment Compared to Matched Control Healthy Participants With Normal Hepatic Function.
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Iptacopan|DRUG: Iptacopan|DRUG: Iptacopan|DRUG: Iptacopan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: School-Age Children With Autism With Limited Expressive Language Skills
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Non-Verbal School Aged Children with Autism (NVSACA) Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of BMS-986142 on the Pharmacokinetics of a Combined Oral Contraceptive (OC) Containing Ethinyl Estradiol (EE) and Norethindrone Acetate (NET) in Healthy Female Subjects
Status: COMPLETED
Conditions: Arthritis
Interventions: DRUG: OC containing EE and NET|DRUG: BMS-986142
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laughter Yoga on the Stress Levels of Infertility Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Laughter Yoga
Interventions: BEHAVIORAL: Laughter Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1 Safety and Pharmacokinetic Study of AI-700 in Patients With Diminished DLCO and COPD and/or CHF
Status: COMPLETED
Conditions: Congestive Heart Failure|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: AI-700
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: ECT
Clinical trial: The Analgesic Efficacy of the Ultrasound-Guided Femoral Articular Branch Block for Ambulatory Hip Arthroscopy
Status: RECRUITING
Conditions: Anesthesia, Regional
Interventions: PROCEDURE: Femoral Articular Branch Block|PROCEDURE: Placebo Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Liver Transplantation for Hilar Cholangiocarcinoma
Status: UNKNOWN
Conditions: Hilar Cholangiocarcinoma
Interventions: OTHER: liver transplantation combined with neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard Versus High Dose Inactivated Influenza Vaccine in RA
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: HD-TIV|BIOLOGICAL: SD-QIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Non-inferiority Trial on Pain Relief During Oocyte Retrieval
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: fentanyl|DRUG: pethidine|DRUG: Diazepam|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Oral Regimens for the Treatment of Chronic HCV Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: LDV/SOF|DRUG: RBV|DRUG: SOF/VEL|DRUG: VOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydroxychloroquine and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: bortezomib|DRUG: hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Reduction of Lymphatic Leakage by Sealing Axillary Lymph Node Dissection Sites
Status: COMPLETED
Conditions: Breast Cancer|Lumpectomy|Mastectomy Plus Axillary Lymph Node Dissection|Lymphatic Leakage
Interventions: DRUG: Fibrin Sealant VH S/D|PROCEDURE: Surgical intervention alone without Fibrin Sealant VH S/D application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of ACT001 and Anti-PD-1 in Patients With Surgically Accessible Recurrent Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Recurrent Glioblastoma Multiforme(GBM)
Interventions: DRUG: ACT001|DRUG: ACT001 + Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of Single-cycle TPF Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: One cycle TPF induction chemotherapy for NPC|DRUG: Three cycles TPF induction chemotherapy for NPC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Bevacizumab on Radiation-induced Brain Necrosis in Patients With Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma|Adverse Effect of Radiation Therapy|Brain Necrosis
Interventions: DRUG: bevacizumab|DRUG: Corticosteroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effectiveness of Eylea in Patients With Wet Age-related Macular Degeneration
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HD17 for Intermediate Stage Hodgkin Lymphoma
Status: COMPLETED
Conditions: Hodgkin Lymphoma
Interventions: DRUG: BEACOPPescalated (Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone)|DRUG: ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine)|RADIATION: 30Gy IF-RT (Involved-Field Radiotherapy)|RADIATION: 30Gy IN-RT (Involved-Node Radiotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPROVE Intervention Trial Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer|Circulating Tumor DNA|Adjuvant Chemotherapy|Progression Free Survival
Interventions: DRUG: Capox (or FOLFOX) including flouropyrimidine and oxaliplatin combination chemotherapy|OTHER: Intensified Follow-up Schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Diffusion of Antibiotics in Patients Admitted for ARDS Following SARS-CoV-2 Pneumonia
Status: RECRUITING
Conditions: ARDS|SARS-CoV 2 Pneumonia
Interventions: OTHER: blood sample and bronchoalveolar lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pilot Study Estradiol Followed by Exemestane Hormone Receptor + Metastatic Breast Cancer
Status: COMPLETED
Conditions: Estrogen Receptor-positive Breast Cancer|Progesterone Receptor Positive Tumor|Recurrent Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: therapeutic estradiol|DRUG: exemestane|OTHER: laboratory biomarker analysis|OTHER: enzyme-linked immunosorbent assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Tapentadol Immediate Release (IR) and Oxycodone IR for Treatment of Acute Post-op Pain Following Elective Arthroscopic (Surgery Using a Thin Flexible Scope) Shoulder Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Tapentadol IR|DRUG: Oxycodone IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab Consolidation in Older (≥ 65) Patients With Primary CNS Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Brain and Nervous System|Eye and Orbit
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Near-Infrared Vein Mapping on Outcomes and Satisfaction After Botox/Filler Treatment
Status: WITHDRAWN
Conditions: Wrinkle
Interventions: DEVICE: Accuvein® Veinfinder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GOAT; Phase I Open Label Study of CGTG-102, a GM-CSF Encoding Oncolytic Adenovirus, for Advanced Cancers
Status: WITHDRAWN
Conditions: Tumors|Solid Tumors
Interventions: BIOLOGICAL: CGTG-102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture for Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Standardized Acupuncture|DEVICE: Non-acupuncture point shallow penetration acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Of Tasocitinib In Dry Eye Subjects
Status: WITHDRAWN
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: Tasocitinib|DRUG: Tasocitinib|DRUG: vehicle for Tasocitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Triple-branched Stent Graft for Aute Debakey Type I Dissection Surgery
Status: RECRUITING
Conditions: Acute Aortic Dissection
Interventions: PROCEDURE: triple-branched stent graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Cognition During a 24-h Simulated Military Operation
Status: COMPLETED
Conditions: Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: beta-alanine|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Learn About the Study Medicine Called PF-07054894 in People of Japanese Origin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-07054894 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Facilitating Improvements in Kidney Health Using a Smartphone App Counseling Program in Patients With Diabetes
Status: COMPLETED
Conditions: Chronic Kidney Disease|Diabetes Mellitus|Albuminuria
Interventions: BEHAVIORAL: Remote counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Physiotherapy Treatments in Temporomandibular Joint Dysfunction
Status: UNKNOWN
Conditions: Pain|Temporomandibular Joint Disorders|Muscle Hypertonia|Myofacial Pain|Analgesia|Musculoskeletal Pain|Craniomandibular Osteopathy
Interventions: PROCEDURE: physiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of CDX-1140, a CD40 Agonist, in Combination With Capecitabine and Oxaliplatin (CAPOX) and Keytruda in Subjects With Biliary Tract Carcinoma (BTC)
Status: RECRUITING
Conditions: Biliary Cancer|Bile Duct Cancer|Cancer of the Bile Duct
Interventions: DRUG: oxaliplatin|DRUG: capecitabine|BIOLOGICAL: Keytruda|BIOLOGICAL: CDX-1140
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Chlorhexidine Gluconate on Prevention of Catheter-Related Bloodstream Infections
Status: RECRUITING
Conditions: Central Venous Catheter Related Bloodstream Infection|Catheter-Related Infections|Bloodstream Infection Due to Central Venous Catheter
Interventions: OTHER: clorhexidine gluconate bathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase
Status: COMPLETED
Conditions: Human African Trypanosomiasis
Interventions: DRUG: Nifurtimox-Eflronithine Combination Treatment (NECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Repaglinide or Bupropion in Advanced Solid Tumor Subjects
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: Apatinib Mesylate|DRUG: Repaglinide|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft Mist Nasal Administration Device for Topical Anaesthesia of the Nasal Cavity
Status: NOT_YET_RECRUITING
Conditions: Anesthesia, Local
Interventions: DEVICE: NAA for topical anaesthesia of the nasal cavity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: A Mobile Application to Improve Case-management and Patient's Functioning in First Episode Psychosis
Status: NOT_YET_RECRUITING
Conditions: Psychosis; Episode
Interventions: BEHAVIORAL: PLAN-e-PSY mobile application|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Short-course Radiotherapy Based TNT Combined With PD-1 Inhibitor for Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: PD-1 antibody|DRUG: Capecitabine|DRUG: Oxaliplatin|RADIATION: Short-course radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Purpose of This Study is to Demonstrate the Safety and Effectiveness of Calcipotriene Foam in Subjects With Scalp and Body Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Calcipotriene Foam|DRUG: Vehicle Foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Posterior Blepharitis
Interventions: DRUG: Loteprednol/tobramycin|DRUG: Loteprednol|DRUG: B+L Advanced Eye Relief Lubricant Drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surufatinib, Toripalimab and Chemotherapy in Second-line MT and MSS CRC
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Surufatinib|DRUG: Toripalimab|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Function and Pharmacogenetics in Renal Transplant Recipients Converted From Tac BID to Tac OD
Status: COMPLETED
Conditions: Real Function Post Conversion From Prograf to Advagraf|Examin Ethnicity and Pharmacogenetics of the Cohort Requiring Dose Adjustment Post-conversion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Outpatient Management of Primary Spontaneous Pneumothorax: Pigtail Catheter With Unidirectional Valve vs. Exsufflation, Randomized Prospective Study
Status: RECRUITING
Conditions: Pneumothorax, Spontaneous
Interventions: PROCEDURE: simple exsufflation|PROCEDURE: Fuhrman catheter and ambulatory care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De-escalation Chemotherapies Versus Escalation in Non Pre-treated Unresectable Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: 5 FLUOROURACYL|DRUG: acide folinique|DRUG: irinotecan|DRUG: Oxaliplatin|DRUG: capécitabine|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Use of Risperidone Long Acting Injectable in the Treatment of Patients With Recent Onset Psychosis
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Risperidone, long-acting injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer
Status: COMPLETED
Conditions: Sarcoma|Neuroblastoma|Wilms Tumor|Leukemia|Lymphoma|Brain Tumors
Interventions: DRUG: Marqibo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Total-body PET Using FDA-approved Radiotracers Beyond 18F-FDG
Status: ENROLLING_BY_INVITATION
Conditions: Prostate Cancer|Breast Cancer|Neuroendocrine Tumors
Interventions: DIAGNOSTIC_TEST: Total-body PET imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Non-inferiority Clinical Trial of CVA Telerehabilitation Treatments - TelePhysioTaiChi
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Tai Chi based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Technical R&D and Demonstration of Intelligent Medical Care in Alzheimer's Disease's Management
Status: RECRUITING
Conditions: Alzheimer Disease|Subjective Cognitive Decline|Mild Cognitive Impairment|Mild Dementia
Interventions: DEVICE: Transcutaneous electrical acupoint stimulation&Music therapy|DRUG: Donepezil hydrochloride tablets or carpalatine bitartrate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Growth Hormone Replacement Therapy for Retried Professional Football Players
Status: RECRUITING
Conditions: TBI (Traumatic Brain Injury)|Concussion, Brain|Sport Injury|Anterior Pituitary Hyposecretion Syndrome|Hypopituitarism|Growth Hormone Deficiency
Interventions: BIOLOGICAL: Growth Hormone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 Compared to Insulin Lispro in Participants With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: LY900014|DRUG: Insulin Lispro|DRUG: Insulin Glargine|DRUG: Insulin Degludec|DRUG: Metformin|DRUG: SGLT2 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction.
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction
Interventions: PROCEDURE: SOC|PROCEDURE: Protocolized up-titration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Intended to Evaluate the Safety and Effectiveness of a Johnson & Johnson Vision Care Inc, (JJVCI) Contact Lens for Use on an Extended-wear Basis for up to 7 Days (6 Nights).
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: etafilcon A|DEVICE: galyfilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Comparative Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone on Postoperative Complications Following Surgical Extraction of Mandibular Third Molar: Randomized Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain
Status: COMPLETED
Conditions: Pain|Back Pain|Low Back Pain|Back Pain With Radiation
Interventions: DRUG: NUCYNTA|DRUG: Oxycodone IR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Lower Limb Rotation on Clinical Outcomes After Arthroscopic Management in Patients With Symptomatic Femoroacetabular Impingement Syndrome
Status: NOT_YET_RECRUITING
Conditions: Femoro Acetabular Impingement
Interventions: PROCEDURE: hip arthroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of New Markers in Type 3 Angioedema
Status: COMPLETED
Conditions: Angio Edema
Interventions: DIAGNOSTIC_TEST: Factor XII dosage|GENETIC: p.Thr328Lys mutation detection|DIAGNOSTIC_TEST: Videocapillaroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer
Status: RECRUITING
Conditions: BRAF NP_004324.2:p.V600M|BRAF V600E Mutation Present|Metastatic Thyroid Gland Carcinoma|Refractory Thyroid Gland Carcinoma|Stage IV Differentiated Thyroid Gland Carcinoma AJCC v8|Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v8|Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v8
Interventions: DRUG: Binimetinib|DRUG: Encorafenib|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer
Status: COMPLETED
Conditions: Anemia|Leukemia|Neutropenia|Thrombocytopenia
Interventions: DRUG: cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Efficacy and Multiple-Dose Plasma Concentration-Time Profiles of Armodafinil and PROVIGIL
Status: COMPLETED
Conditions: Chronic Shift Work Sleep Disorder
Interventions: DRUG: PROVIGIL 200 mg|DRUG: Armodafinil 250 mg|DRUG: Armodafinil 200 mg|DRUG: Armodafinil 150 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness
Status: COMPLETED
Conditions: Bipolar Disorder|Schizophrenia|Schizoaffective Disorder|Nicotine Dependence
Interventions: DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Building Resiliency in Dyads of Patients With an ANI Admitted to the Neuro-ICU and Their Informal Caregivers
Status: RECRUITING
Conditions: Acute Neurological Injury|Emotional Distress
Interventions: BEHAVIORAL: Recovering Together|BEHAVIORAL: Recovering Together
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Speech Therapy Session Frequency and Speech Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Speech Therapy|Language Disorders in Children|Articulation Disorders in Children|Communication Disorder, Childhood|Pediatric
Interventions: BEHAVIORAL: Speech Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of OxyjunTM on Cardiac Pumping Capacity as Well as Work Productivity in Individuals With Metabolic Risk.
Status: NOT_YET_RECRUITING
Conditions: Metabolic Disorder
Interventions: DIETARY_SUPPLEMENT: Oxyjun TM|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Nu-V3 Non-Invasive Nerve Stimulation Device Trial for Chronic Pain, Anxiety, Depression, Sleeplessness
Status: TERMINATED
Conditions: Chronic Pain|Anxiety|Depression|Sleeplessness
Interventions: DEVICE: Nu-V3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Frequency Oscillation in Pediatric Epilepsy Surgery
Status: COMPLETED
Conditions: Pediatric Epilepsy|Epilepsy Surgery|High Frequency Oscillation
Interventions: DIAGNOSTIC_TEST: HFO analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Pirtobrutinib|DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Pulpal Response After Pulp Capping With Four Different Agents
Status: COMPLETED
Conditions: Dental Pulp Exposure
Interventions: DRUG: Pro Root MTA|DRUG: Pro Root MTA- single visit|DRUG: MultiCal|DRUG: Dycal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Bioactive Compounds in Lipid Profile
Status: COMPLETED
Conditions: Hyperlipidemia|Low-density-lipoprotein-type|Elevated Triglycerides
Interventions: DIETARY_SUPPLEMENT: Armolipid Plus|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Epidural Fentanyl for 2nd Stage Labor Analgesia
Status: RECRUITING
Conditions: Labor Pain
Interventions: DRUG: Fentanyl 20 mcg|DRUG: Fentanyl 100 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies
Status: NOT_YET_RECRUITING
Conditions: SMARCB1-Deficient Malignancies
Interventions: DRUG: Ubamatamab|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-dimer Assay for the Exclusion of Intra-atrial Thrombus Risk Before Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: OTHER: D-dimer assay before ablation of atrial fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Bio-impedance Analysis and Vitamin D vs Usual Care on Left Ventricular Mass in Peritoneal Dialysis Patients: A Randomized Controlled Trial (FLUID Study)
Status: UNKNOWN
Conditions: Peritoneal Dialysis
Interventions: DRUG: Bioimpedance and Vitamin D|DRUG: Usual care and placebo|DRUG: Usual care and Vitamin D|DEVICE: Bioimpedance and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: eRT Remote Health Monitoring
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|COPD|Chronic Obstructive Lung Disease|Bronchitis, Chronic|Pulmonary Emphysema
Interventions: BEHAVIORAL: Remote Health Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 3b, Open-label, Multi-center Study on Durvalumab in Combination With Gemcitabine-based Chemotherapy as 1L Treatment for the Chinese Patients With Unresectable Biliary Tract Cancers (BTC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Tract Cancers
Interventions: DRUG: durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramucirumab or Anti-PDGFR Alpha Monoclonal Antibody IMC-3G3 in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Glioblastoma Multiforme
Interventions: BIOLOGICAL: olaratumab|BIOLOGICAL: ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Strasbourg Environmental Exposure Chamber ALYATEC in Mite Allergic Subjects With Asthma
Status: COMPLETED
Conditions: Allergic Asthma|Allergy to House Dust|Allergy
Interventions: OTHER: Exposure to placebo in EEC|OTHER: Exposure to three concentrations of HDM allergen in EEC|OTHER: Exposure to a single concentration of HDM allergen in EEC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Duration of Hypothermia for Neuroprotection After Pediatric Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest|Brain Injury
Interventions: OTHER: 72 hours hypothermia|OTHER: 24 hours hypothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial
Status: COMPLETED
Conditions: Anal Fissure|Constipation
Interventions: DRUG: Polyethylene Glycol|DRUG: Isabgol + Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subcision With PRP and Microneedling Versus Subcision With Saline and Micro-needling in Treatment of Posttraumatic Scars
Status: COMPLETED
Conditions: Post-Traumatic Scar
Interventions: OTHER: subcision ,PRP or saline and microneedling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Flortaucipir PET in Healthy Volunteers and Cognitively Impaired Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Flortaucipir F18|PROCEDURE: Brain PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Autologous Bone Marrow Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failure
Status: UNKNOWN
Conditions: Premature Ovarian Failure (POF)
Interventions: DRUG: G-CSF|COMBINATION_PRODUCT: ASCOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CytoSorb Adsorber on Hemodynamic and Immunological Parameters in Critical Ill Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DEVICE: CytoSorb-Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Re-education Program in Subjects With Parkinson´s Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: GAIT RE-EDUCATION PROGRAM ON A SEQUENTIAL MAT IN SUBJECTS WITH PARKINSON'S DISEASE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Euminz® for Tension-Type Headache
Status: COMPLETED
Conditions: Episodic Tension-Type Headache
Interventions: DRUG: Euminz®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chromoendoscopy in Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Colonoscopy
Interventions: PROCEDURE: indigo-carmine 0.2% using a spray catheter|PROCEDURE: 0.03% using a foot pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Targeting Peroxisome Proliferator-activated Receptor-gamma in Peritoneal Dialysis Patients - Will it Reduce Inflammation, Atherosclerosis, Calcification and Improve Survival of Peritoneal Dialysis Patients?
Status: UNKNOWN
Conditions: Chronic Disease|Kidney Diseases|Cardiovascular Diseases
Interventions: DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanoma
Status: RECRUITING
Conditions: Metastatic Uveal Melanoma
Interventions: DRUG: ZIV-Aflibercept|DRUG: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, and Efficacy of SUVN-G3031 (Samelisant) in Patients With Narcolepsy With and Without Cataplexy
Status: COMPLETED
Conditions: Narcolepsy
Interventions: DRUG: SUVN-G3031|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT
Status: COMPLETED
Conditions: Appendicitis
Interventions: RADIATION: Diagnostic CT|RADIATION: Diagnostic CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pediatric Orthopaedic Implant Safety & Efficacy
Status: RECRUITING
Conditions: Fracture|Lengthening; Leg|Orthopedic Disorder|Deformity of Limb|Deformity; Bone|Implant Breakage|Implant Complication|Hip Dysplasia|Pediatric ALL|Hip Disease|Hip Dislocation
Interventions: DEVICE: Pediatric orthopaedic implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Premium Monovision Versus Other Types of Monovision and Bilateral Trifocal Implantation.
Status: COMPLETED
Conditions: Presbyopia|Refractive Errors|Cataract
Interventions: DIAGNOSTIC_TEST: bUD-VA,bUN-RA, bUI-RA, bUI-CPS, bUN-CPS, contrast sensitivity
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|High Grade B-Cell Lymphoma|Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Lenalidomide|BIOLOGICAL: Mosunetuzumab|DRUG: Polatuzumab Vedotin|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Multi-marker Screening and Treatment With Aspirin for Pre-eclampsia Prevention
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Long-term Retinal Changes After Topical Citicoline Administration in Patients With Mild Signs of Diabetic Retinopathy in Type 1 Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: OTHER: OMK2 group|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Effectiveness Evaluation in Stroke Patients Using Lower Limb Assistive Walking Devices
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: MI-R1 lower limb walking machine assisted training device|OTHER: Walking rehabilitation training under the guidance of therapists
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Recombinant Protein Vaccines With Adjuvant as a Primary Series and as a Booster Dose Against COVID-19 in Adults 18 Years of Age and Older
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 recombinant protein vaccine Phase 2 Formulation 1|BIOLOGICAL: SARS-CoV-2 recombinant protein vaccine Phase 2 Formulation 2|BIOLOGICAL: SARS-CoV-2 recombinant protein vaccine Phase 2 Formulation 3|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (D614)-AS03, Dosage A|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (D614)-AS03, Dosage B|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 1|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 2|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 3|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, monovalent (B.1.351)-AS03 Alternative Exploratory Formulation 4|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine, bivalent (D614+B.1.351)-AS03
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Microcirculation & ASICs
Status: COMPLETED
Conditions: Physiological Conditions
Interventions: DRUG: Diclofenac|DRUG: Amiloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tissue K+ in Primary Hyperaldosteronism
Status: RECRUITING
Conditions: Primary Hyperaldosteronism|Electrolyte Disturbance
Interventions: PROCEDURE: Surgical Treatment of Hyperaldosteronism|DRUG: Drug treatment of Hyperaldosteronism
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Status: COMPLETED
Conditions: Early Ventilator Associated Pneumonia
Interventions: DRUG: Default 4 days antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot|Diabetic Foot Ulcer|Foot Ulcer, Diabetic|Foot Wound
Interventions: BEHAVIORAL: Lifestyle-focused Occupational Therapy Intervention|OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION