pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of the Postbiotic Blend ABB C3 on Adiposity and Glucose Metabolism in Children and Adolescents
Status: RECRUITING
Conditions: Obesity, Childhood|Obesity, Adolescent
Interventions: DIETARY_SUPPLEMENT: Postbiotic ABB C3|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Follow-up Postbiotic ABB C3 (Optional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carry-over Effects of Repetitively Applied Transcutaneous Spinal Cord Stimulation on Spasticity
Status: WITHDRAWN
Conditions: Spinal Cord Injuries|Spasticity, Muscle
Interventions: DEVICE: Stimulette r2x+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Status: RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: [13N]NH3|DRUG: Lexiscan|DIAGNOSTIC_TEST: Positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I - Pre-Radical Prostatectomy RTVP-1 Gene Therapy for Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: GENETIC: RTVP-1 Gene
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Smoking Cessation Intervention for Yale Dining Employees
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Contingency management|DRUG: Nicotine replacement therapy|DRUG: Varenicline|BEHAVIORAL: Additional behavioral support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess Force Required to Dislodge Upper Denture With and Without Use of a Novel Denture Adhesive
Status: WITHDRAWN
Conditions: Denture Retention
Interventions: DEVICE: Investigational denture adhesive cream|DEVICE: Super Poligrip Free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Simethicone on Reducing Bowel Interference During Tubal Resection
Status: COMPLETED
Conditions: Sterility, Postpartum
Interventions: DRUG: Simethicone 80 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Antioxidant Efficacy of a Product Probiotic in Research
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus, Lactobacillus casei y Bifidobacterium longum (100MG)|DIETARY_SUPPLEMENT: Lactobacillus rhamnosus, Lactobacillus casei y Bifidobacterium longum (300MG)|DIETARY_SUPPLEMENT: maltodextrin and sucrose (PLACEBO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Venetoclax Combined With CACAG Regimen in the Treatment of Newly Diagnosed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacytidine;Cytarabine;Aclacinomycin;Chidamide;Venetoclax;Granulocyte colony-stimulating factor|DRUG: "3+7"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: DRUG: Ipratropium bromide|DRUG: Magnesium Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Potential Intervention Strategy With Folic Acid and Vitamin B12 in Patients With Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DIETARY_SUPPLEMENT: folic acid 5 mg/cap|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Parkinson Kinetigraph Recordings on the Management and Outcome in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DEVICE: Parkinson KinetiGraph|OTHER: Self assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Reproducibility of Keratometric Measurements and Influencing Factors in Cataract Patients
Status: COMPLETED
Conditions: Cataract|Dry Eye
Interventions: DEVICE: High viscous artificial tears|DEVICE: Low viscous artificial tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Spine Surgical Care With Real-Time Objective Patient Tracking Using the Apple Watch
Status: ACTIVE_NOT_RECRUITING
Conditions: Spine Disease|Spine Degeneration|Spinal Stenosis|Surgery|Spine Fusion
Interventions: DEVICE: Apple Watch and App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intraperitoneal Lavage for Reducing Pain in Laparoscopy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: intraperitoneal washing with saline solution|PROCEDURE: No washing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Smartphone-based Treatment for Bipolar Disorder - the Smart Bipolar
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: DEVICE: The Monsenso system with feedback|DEVICE: The Monsenso system without feedback|DEVICE: CAG Bipola and mood monitoring only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: GENETIC: delandistrogene moxeparvovec|GENETIC: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hepatitis B Birth Dose for Newborns
Status: COMPLETED
Conditions: Hepatitis B|Immunization; Infection
Interventions: BIOLOGICAL: recombinant hepatitis B vaccine ENGERIX 10 micrograms (µ gm),|BEHAVIORAL: Short text messages and calls to parents for compliance to routine immunization schedule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Feasibility of a Facebook Group-based Program for Foot Self-management Support of Adults With Diabetes in Canada
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: BEHAVIORAL: Diabetic foot self-management support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome
Status: RECRUITING
Conditions: Coronary Heart Disease
Interventions: DIAGNOSTIC_TEST: Collection of blood samples to determine the level of certain cytokines (TNF-α, IL-1β, IL-4 and IL-10),Collection of blood samples to determine the level of uric acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trans Cranial Brain Stimulation for Stroke Rehabilitation
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Real Transcranial direct stimulation+Mental Imagery|OTHER: Sham Transcranial Direct Stimulation +Mental Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Program of Deep Inspiration Combined to Expiratory Positive Airway Pressure in Asthmatic
Status: COMPLETED
Conditions: Improvement of Functional Capacity.|Improvement of Quality of Life.|Improvement of Cardiovascular Autonomic Control.
Interventions: OTHER: Deep inspiration and positive expiratory airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pazopanib With or Without Pembrolizumab for Metastatic Soft Tissue Sarcoma
Status: NOT_YET_RECRUITING
Conditions: Soft Tissue Sarcoma
Interventions: DRUG: pembrolizumab, pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wideband Tympanometry for Monitoring Intracranial Pressure in Adult Patients in Intensive Care, Operated on for an Intracranial Lesion After Traumatic Brain Injury, or With Intracranial Hemorrhage
Status: COMPLETED
Conditions: Intracranial Pressure
Interventions: OTHER: Tympanometry measurement in both ears|OTHER: Collection of clinical and paraclinical data|OTHER: Intracranial pressure reading (ICP)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization
Status: UNKNOWN
Conditions: Coronary Artery Disease(CAD)
Interventions: DRUG: Shexiang Baoxin pill|DRUG: SBP placebo|DRUG: Aspirin Enteric-coated Tablets|DRUG: Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet|DRUG: Atorvastatin Calcium|DRUG: Isosorbide Mononitrate Tab 20 MG|DRUG: Metoprolol Tartrate Tab 25 MG|DRUG: Trimetazidine Dihydrochloride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pemetrexed/Cisplatin as Pre-operative Treatment of Early Stage Nonsquamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Folic Acid|DRUG: Vitamin B12|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Cavex Bite&White ExSense|OTHER: Colgate, Protection Caries|OTHER: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A School-Based HIV/STD Prevention Program to Reduce Risky Sexual Behaviors Among Adolescents in Liberia
Status: COMPLETED
Conditions: HIV Infections
Interventions: BEHAVIORAL: HIV/STD prevention curriculum|BEHAVIORAL: General health promotion curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Multiple Ascending Dose Study to Evaluate the Safety, Tolerability of DC371739 Treatment in Hypercholesterolemic
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: DC371739 Tablets|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan
Status: NOT_YET_RECRUITING
Conditions: Smoking Cessation|Electronic Cigarette Use
Interventions: DEVICE: Electronic Cigarette (EC)|DRUG: Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Benefit of Chromoendoscopy in Addition to High Definition White Light and Narrow Band Imaging for the Prediction of Submucosal Invasive Cancer in Colonic Lesions
Status: COMPLETED
Conditions: Colonic Adenoma|Colon Polyp|Submucosal Invasive Colon Adenocarcinoma|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: chromoendoscopy, high definition white light and narrow band imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extracorporeal Photopheresis and Early Cardiac Graft Vasculopathy
Status: COMPLETED
Conditions: Cardiac Allograft Vasculopathy|Heart Transplant Rejection
Interventions: PROCEDURE: Extracoropreal photopheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Safety and Pharmacokinetic Study of CVX-096 in Type 2 Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BIOLOGICAL: CVX-096
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MCO Membrane Efficiency in Septic Shock Patients
Status: COMPLETED
Conditions: Septic Shock|Acute Kidney Injury
Interventions: DEVICE: Ultraflux® EMiC®2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: DMT310-009 Topical in the Treatment of Acne Vulgaris
Status: RECRUITING
Conditions: Acne Vulgaris
Interventions: DRUG: DMT310|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Left Main Coronary Artery Stenosis|Left Main Coronary Artery Disease|Restenosis, Coronary
Interventions: OTHER: Indication of revascularization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Physical Therapy for Functional Constipation in Children
Status: COMPLETED
Conditions: Physical Therapy in Pediatric Functional Constipation
Interventions: DRUG: Polyethylene Glycols|OTHER: Physical therapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Small Genital Warts
Status: UNKNOWN
Conditions: Genital Warts
Interventions: PROCEDURE: Aminolevulinic acid photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Imatinib (Glivec) in Patients With Adenoid Cystic Carcinoma of the Head and Neck
Status: UNKNOWN
Conditions: Cancer of the Head and Neck|Carcinoma, Adenoid Cystic
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Long-term Safety and Efficacy of Tolvaptan in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Extension of Trial 156-04-251 in Japan]
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney Disease （ADPKD)
Interventions: DRUG: tolvaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Organisational Models Supported by Technology for the Management of Diabetic Disease and Its Complications in a Diabetic Clinic Setting. A Randomised Controlled Trial Targeting Type 2 Diabetes Individuals With Non-ideal Glycemic Values
Status: RECRUITING
Conditions: Diabetes type2
Interventions: OTHER: TreC Diabete App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of White Adipose Tissue Remodeling by Cryolipolysis in Humans
Status: UNKNOWN
Conditions: Lipid Metabolism Disorders|Metabolic Disease
Interventions: DEVICE: CoolSculpting® System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Influence of Oxytocin on Neurophysiological Responses to Live Faces
Status: COMPLETED
Conditions: Oxytocin
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Sentinel Node Biopsy Omission for Breast Cancer Patients Who Plan to Have Adjuvant Chemotherapy
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: PROCEDURE: Lumpectomy without sentinel node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorders|Mood Disorders|Affective Disorders, Psychotic
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: To Determine the Fasting Bioequivalence of Reformulated OXY Tablets Manufactured at Two Different Facilities
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Reformulated OXY (Totowa) (oxycodone HCl)|DRUG: Reformulated OXY (Wilson) (oxycodone HCl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Intervention Study of Two Protocols for Non-surgical Treatment of Chronic Periodontitis
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Full-mouth ultrasonic debridement|PROCEDURE: Section-wise scaling and root planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ulinastatin in Severe Acute Pancreatitis
Status: SUSPENDED
Conditions: Pancreatitis
Interventions: DRUG: ulinastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm
Interventions: DRUG: Larotrectinib Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: PROCEDURE: Physiotherapy, exercise, percutaneous gastrostomy feeds|DRUG: Anti-reflux pharmacotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Incentive Spirometer Training in Type 2 Diabetes With Sarcopenia
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes|Sarcopenia
Interventions: BEHAVIORAL: incentive spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia
Status: COMPLETED
Conditions: Hypoxic-Ischemic Encephalopathy|Post-Cardiorespiratory Arrest Coma|Cardiac Arrest
Interventions: DEVICE: Near-infrared spectroscopy (NIRS) (INVOS®, Covidien)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Of AG-013736 (Axitinib) Or Bevacizumab (Avastin) In Combination With Paclitaxel And Carboplatin In Patients With Advanced Lung Cancer.
Status: COMPLETED
Conditions: Non-Small-Cell Lung Carcinoma|Adenocarcinoma
Interventions: DRUG: Bevacizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: AG-013736 (axitinib)|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness and Safety of Low-intensity Single-wavelength Red Light in Controlling High Myopia in Children and Adolescents：A Randomized, Controlled, Multicenter Clinical Trial
Status: COMPLETED
Conditions: Age 3 to 16 Years (Inclusive), Male or Female|Clinical Diagnosis Confirming That Myopia Has Occurred in at Least One Eye|The Guardian Voluntarily Signed the Subject's Informed Consent Form
Interventions: OTHER: Eyesing Redlight Instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A First in Human Study of the Safety and Tolerability of Single and Multiple Doses of BWC0977 in Healthy Volunteers
Status: COMPLETED
Conditions: Infectious Diseases|Bacterial Infections
Interventions: DRUG: BWC0977|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
Status: ENROLLING_BY_INVITATION
Conditions: Substance-Related Disorders|Opioid-Related Disorders
Interventions: BEHAVIORAL: Data-Driven Decision Making (DDDM)|BEHAVIORAL: Overdose-prevention strategies inventory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Kefir Whey Postbiotics
Status: RECRUITING
Conditions: Sarcopenia
Interventions: DIETARY_SUPPLEMENT: Whey postbiotics derived from kefir lactic acid bacteria|DIETARY_SUPPLEMENT: Placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SMA Targeted Magnetic Stimulation Against Auditory Verbal Hallucinations
Status: TERMINATED
Conditions: Auditory Hallucination
Interventions: DEVICE: continuous theta burst stimulation over the SMA|DEVICE: sham continuous theta burst stimulation over the SMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DRUG: Ranibizumab 0.3 mg - 3 times monthly, then quarterly|DRUG: Ranibizumab 0.5 mg - 3 times monthly, then quarterly|DRUG: Ranibizumab 0.3 mg monthly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Radiotherapy in the Adjuvant Treatment of Resistant Breast Cancer
Status: COMPLETED
Conditions: Resistant Breast Cancer|Non-metastatic Invasive Breast Cancer
Interventions: DRUG: Capecitabine|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Biologic Therapy on Surgical Outcomes for Perforated Crohn's Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: BIOLOGICAL: early biologic therapy|BIOLOGICAL: late biologic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human Dose Escalation of M3258 as a Single Agent and Expansion Study of M3258 in Combination With Dexamethasone
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: M3258|DRUG: M3258 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMplementation of the Family Support PRogramme A Healthy School Start to Prevent OVErweight and Obesity (IMPROVE)
Status: RECRUITING
Conditions: Pediatric Obesity|Overnutrition, Child|Prediabetic State|Diabetes Mellitus, Type 2|Overweight, Childhood
Interventions: BEHAVIORAL: Healthy School Start
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Understanding Typhoid Disease After Vaccination
Status: COMPLETED
Conditions: Typhoid Fever|Enteric Fever|Typhoid
Interventions: BIOLOGICAL: Vaccine placebo (excipients only)|BIOLOGICAL: Ty21a|BIOLOGICAL: M10ZH09 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HPV Educational Intervention to Increase Acceptance and Completion of Free HPV Vaccination Among Underserved Adults
Status: RECRUITING
Conditions: Human Papillomavirus Infection|Human Papillomavirus-Related Carcinoma
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery
Status: UNKNOWN
Conditions: Hyperalgesia
Interventions: DRUG: propofol, sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Adding Corticosteroid to Viscosupplementation
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Hylan GF-20 alone|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: UNKNOWN
Conditions: COPD|Obstructive Ventilation Disorder|Pulmonary Emphysema
Interventions: DEVICE: impulse oscillometry|DEVICE: multiple breath washout test|DEVICE: body plethysmography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect Of Hydrocortisone Phonophoresis Versus Iontophoresis In Patients With Subacromial Impingement Syndrome
Status: RECRUITING
Conditions: Impingement Syndrome|Subacromial Impingement Syndrome
Interventions: OTHER: Therapeutic exercise|OTHER: hydrocortisone phonophoresis|OTHER: hydrocortisone iontophoresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Gastro-Intestinal Function to a Mixed Meal by Non-invasive Imaging
Status: COMPLETED
Conditions: Functional Dyspepsia|Diabetic Gastroparesis
Interventions: OTHER: Magnetic Resonance Imaging MRI|OTHER: Gamma Scintigraphy|PROCEDURE: Assessment of Gastric motor and sensory function
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Food'to'Go - a Feasibility Study of Post-discharge Meals for Older Patients by the Use of ICT-technology
Status: COMPLETED
Conditions: Malnutrition
Interventions: DEVICE: Tablet computer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Autologous Platelet-rich Plasma With Hyaluronic Acid for the Treatment of Osteoarthritis of the Knee Joint
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: PRP|DRUG: Hyaluronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About How BAY 3283142 Moves Into, Through, and Out of the Body After a Single Dose in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function
Status: RECRUITING
Conditions: Chronic Kidney Disease|Hepatic Impairment
Interventions: DRUG: BAY3283142
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
Status: COMPLETED
Conditions: Ankle Fracture
Interventions: DRUG: Liposomal Bupivacaine with Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate Etokimab (ANB020) Activity in Adult Participants With Peanut Allergy
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: DRUG: Etokimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tranexamic Acid on Blood Coagulation in Total Hip Arthroplasty Surgery
Status: COMPLETED
Conditions: Coagulation; Intravascular|Rotational Thromboelastometry|Fibrinolysis; Hemorrhage|Tranexamic Acid|Total Hip Arthroplasty
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Low-dose Oral Clofarabine for the Treatment of IPSS INT-1, INT-2 or HIGH Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia
Status: TERMINATED
Conditions: Cancer|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Intraoperative Coronary Bypass Graft Imaging to Improve Graft Patency
Status: COMPLETED
Conditions: Coronary Disease
Interventions: PROCEDURE: Indocyanine green intraoperative angiogram and transit-time flowmetry
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Dose-escalation Study to Evaluate the Safety and Pharmacokinetics (PK) of Palifermin in Subjects With Acute Leukemias Undergoing HSCT
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Palifermin|RADIATION: Total Body irradiation|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility and Safety of Hybrid Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Colon Cancer
Status: RECRUITING
Conditions: Colon Cancer|Natural Orifice Transluminal Endoscopic Surgery
Interventions: PROCEDURE: hvNOTES radical colectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbralisib Plus Ublituximab (U2) in Progressive CLL After Novel Therapy
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|CLL Progression|CLL/SLL
Interventions: DRUG: Umbralisib|DRUG: Ublituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)
Status: TERMINATED
Conditions: Treatment Resistant Depression
Interventions: DRUG: MK-1942|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Self-regulation in Children With Neurodevelopmental Disorders:
Status: UNKNOWN
Conditions: Child Behavior Disorders|ASD|ADHD
Interventions: BEHAVIORAL: Self-regulation: MRehab - Un colegio emocionante, clinical trial with non-immersive virtual reality|BEHAVIORAL: Traditional self-regulation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Osteoprotector Effects of a Milk Product Based on Anthocyans and Enriched in Calcium and Vitamin D
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Anthocyans, Calcium and Vitamin D|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Correction of Anisometropic Amblyopia in Children.
Status: UNKNOWN
Conditions: Amblyopia|Anisometropic Amblyopia|Anisometropia and Aniseikonia|Refractive Errors
Interventions: DIAGNOSTIC_TEST: Axial length measurement in millimeter (mm) by optical biometry device|DIAGNOSTIC_TEST: Autorefractometer to measure the refractive error in both eyes.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Psychological Strain and Perioperative Fear in Intravitreal Injections
Status: COMPLETED
Conditions: Age-related Macular Degeneration|Stress
Interventions: BEHAVIORAL: Preoperative information and perioperative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pyrotinib in Combination With Capecitabine in Patients With Trastuzumab-resistant HER2-positive Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pyrotinib combined with capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy and Primary Stability of Straight and Tapered Implants in Immediate Implant Placement Using Dynamic Navigation
Status: COMPLETED
Conditions: Tooth Diseases
Interventions: PROCEDURE: Tapered Implants|PROCEDURE: Straight Implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial
Status: COMPLETED
Conditions: Knee Arthroplasty, Total|Osteoarthritis|Radiologic Tibiofemoral Osteoarthritis
Interventions: PROCEDURE: Genicular Nerve RFA|PROCEDURE: Sham Genicular Nerve RFA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing of Two Different Chemotherapy Regimens, in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: pemetrexed|DRUG: Best Supportive Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Docetaxel in Treating Patients With Relapsed or Refractory Ovarian Epithelial or Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: DRUG: Docetaxel|DRUG: Gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Amphotericin B Liposome for Injection
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Amphotericin B liposome for injection|DRUG: AmBisome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of EBPSI on Future Suicide Risk Among Adolescent Suicide Attempters
Status: RECRUITING
Conditions: Suicide, Attempted
Interventions: BEHAVIORAL: Electronic Based Psychosocial Intervention (EBPSI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Formulation and Food Effect Study of BIIB074
Status: COMPLETED
Conditions: Trigeminal Neuralgia (TN)|Other Neuropathic Pain
Interventions: DRUG: BIIB074 Treatment A|DRUG: BIIB074 Treatment B|DRUG: BIIB074 Treatment C|DRUG: BIIB074 Treatment D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Samidorphan|DRUG: Placebo|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Umbilical Cord Blood Regulatory T Cells Plus Liraglutide on Autoimmune Diabetes
Status: RECRUITING
Conditions: Type1 Diabetes Mellitus|Autoimmune Diabetes
Interventions: DRUG: Liraglutide|BIOLOGICAL: UCB-Treg|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delayed Onset Muscle Soreness of Athletes
Status: NOT_YET_RECRUITING
Conditions: Delayed Onset Muscle Soreness
Interventions: OTHER: vibration training|OTHER: vibration training|OTHER: Y-shaped kinesio taping|OTHER: Combined vibration training and Y-shaped kinesio taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PCLE for the Diagnosis of Gastric Intestinal Metaplasia, Intraepithelial Neoplasia, and Carcinoma
Status: UNKNOWN
Conditions: Diagnostic Yield of Gastric Neoplasia
Interventions: DEVICE: pCLE-TB|DEVICE: virtual chromoendoscopy-TB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Single-dose Novel Selective alpha2c Antagonist Pharmaco-MRI Study in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: ORM-12741|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lactoferrin for Prevention of COVID-19 in Health Care Workers
Status: TERMINATED
Conditions: SARS-CoV-2
Interventions: DRUG: Bovine Lactoferrin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Stress CT Myocardial Perfusion on Downstream Resources and Prognosis
Status: UNKNOWN
Conditions: Coronary Artery Disease|Myocardial Ischemia
Interventions: DIAGNOSTIC_TEST: Integration of CCTA with stress CTP when indicated|DIAGNOSTIC_TEST: Standard of care approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study in Type 2 Diabetic Subjects on Stable Metformin Therapy to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administering Single and Multiple Oral Doses of GSK1292263
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: GSK1292263|DRUG: GSK1292263 matching placebo|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms
Interventions: DRUG: Encorafenib|DRUG: Cetuximab|DRUG: Oxaliplatin|DRUG: Irinotecan|DRUG: Leucovorin|DRUG: 5-FU|DRUG: Capecitabine|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European Phase III Study of APD421 in PONV
Status: COMPLETED
Conditions: PONV
Interventions: DRUG: APD421|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Nasal Insulin to Fight Forgetfulness - Device Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Cognitive Impairment
Interventions: DRUG: Insulin|OTHER: Placebo|DEVICE: intranasal nebulizer-like device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Non Erosive Reflux Disease
Status: COMPLETED
Conditions: Non-erosive Reflux Disease
Interventions: DRUG: CJ-12420 50mg|DRUG: CJ-12420 100mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of LY2189265 on Blood Pressure and Heart Rate in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: LY2189265|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: French Registry for Monitoring Pregnancies for Multiple Sclerosis
Status: RECRUITING
Conditions: Sclerosis, Multiple|Neuromyelitis Optica Spectrum Disorder|Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders|Pregnancy Abnormal
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Inferior Oblique Muscle Recession and Myectomy
Status: UNKNOWN
Conditions: Inferior Oblique Muscle Overactivity
Interventions: PROCEDURE: Inferior Oblique Muscle Recession and Myectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gingival Margin Stability Following Esthetic Crown Lengthening Utilizing a Double Periodontal Surgical Guide
Status: NOT_YET_RECRUITING
Conditions: Crown Lengthening
Interventions: PROCEDURE: Crown lengthening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TRUST-2: Safety and Efficacy of Intravenous Remodulin® in Patients in India With Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Intravenous Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Liposomated Iron After Bariatric Surgery in Patients That Are Receiving Parentheral Therapy With Iron
Status: COMPLETED
Conditions: Liposomated Iron|Y-de-Roux Gastric By-Pass|Parenteral Iron Therapy
Interventions: DRUG: Fisiogen Ferro Forte|DRUG: Venofer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of [68Ga]-FF58 in Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins.
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Brain Neoplasms|Gastroesophageal Adenocarcinoma|Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: 68Ga-FF58
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acute Effects of Autoregulated and Non-autoregulated Blood Flow Restrictive Bicep Curls
Status: RECRUITING
Conditions: Arterial Stiffness|Healthy Lifestyle
Interventions: DEVICE: Delfi Personal Tourniquet Systems
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Anastrozole|DRUG: Letrozole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: CryoCath Freezor CryoAblation Catheter System (CRYOFACTS)
Status: COMPLETED
Conditions: Tachycardia, Atrioventricular Nodal Reentry
Interventions: DEVICE: Freezor® Cardiac Cryoablation Catheter CryoConsole System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care
Status: COMPLETED
Conditions: Venous Ulcers
Interventions: DEVICE: Two multilayer compression bandage|DEVICE: Crepe bandage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT