pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing
Status: COMPLETED
Conditions: BRCA1 Mutation|BRCA2 Mutation|Psychosocial Factors
Interventions: BEHAVIORAL: Message comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Individualized Intervention(s) in Hormone-Receptor Positive Early-stage Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Premenopausal Breast Cancer|Hormone Receptor Positive Tumor
Interventions: BEHAVIORAL: Individualized interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impacts and Testing of the "Multi-domains Active-living Program" in Operable Non-Muscle Invasive Bladder Cancer Patients
Status: RECRUITING
Conditions: Bladder Cancer|Quality of Life
Interventions: OTHER: Usual care + oncology case manager (OCM) care|OTHER: Multi-domains Active-living Program (MAP) with e-health enhanced intervention + usual care + oncology case manager (OCM) care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of MGN1703 Maintenance Treatment in Patients With mCRC With Tumor Reduction During Induction Treatment
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: OTHER: Usual Maintenance|DRUG: MGN1703 treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cystic Fibrosis|Cystic Fibrosis Liver Disease|Cystic Fibrosis in Children|Adherence, Medication|Cystic Fibrosis Gastrointestinal Disease
Interventions: DRUG: Kaftrio
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Contraception and Menstrual Cycle Effect on Pharmacokinetics, Pharmacodynamics and Safety in Tenofovir Vaginal Gel Use
Status: COMPLETED
Conditions: HIV Prevention
Interventions: DRUG: Tenofovir 1% vaginal gel|DRUG: Depo-medroxyprogesterone acetate (DMPA)|DRUG: Oral contraceptive: LNG 150 mcg and EE 30 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers
Status: RECRUITING
Conditions: Metastatic Small Intestinal Adenocarcinoma|Stage III Small Intestinal Adenocarcinoma AJCC v8|Stage IIIA Small Intestinal Adenocarcinoma AJCC v8|Stage IIIB Small Intestinal Adenocarcinoma AJCC v8|Stage IV Small Intestinal Adenocarcinoma AJCC v8
Interventions: DRUG: Fluorouracil|DRUG: Irinotecan|DRUG: Irinotecan Hydrochloride|DRUG: Leucovorin|DRUG: Leucovorin Calcium|DRUG: Paclitaxel|BIOLOGICAL: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Flexor Hallucis Longus Transfer vs Minimally Invasive Repair in Acute Achilles Tendon Rupture
Status: ENROLLING_BY_INVITATION
Conditions: Achilles Tendon Rupture|Achilles Tendon Surgery|Achilles Tendon Injury
Interventions: PROCEDURE: Surgery for the treatment of Acute Achilles tendon rupture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accelerated Non-Atherosclerotic Brain Arterial Aging Relationship to Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Dementia
Interventions: DRUG: 11C-ER176|DRUG: [F-18]MK-6240|DRUG: Florbetaben|OTHER: Magnetic Resonance Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran
Status: RECRUITING
Conditions: Transthyretin Amyloidosis|Amyloidosis, Hereditary
Interventions: OTHER: Six minutes walk test|OTHER: Kansas City questionnaire|OTHER: COMPASS31 self questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant Treatment of Tislelizumab Combined Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma ：A Single-arm, Prospective, Phase II Trial
Status: RECRUITING
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: Tislelizumab|DRUG: Albumin paclitaxel|DRUG: Cisplatin|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corticosteroids and Anti TNF in Methotrexate Inadequate Responder Rheumatoid Arthritis Patient
Status: UNKNOWN
Conditions: RHEUMATOID ARTHRITIS
Interventions: DRUG: Pred + Meth|DRUG: Anti TNF + Meth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of the Role of Anti-CEA Antibody Immunoscintigraphy & Positron Emission Tomography in the Localization of Recurrent Colorectal Carcinoma in Patients With Rising Serum CEA Levels in the Absence of Imageable Disease by Conventional Modalities
Status: COMPLETED
Conditions: Colorectal Neoplasm
Interventions: DRUG: 2-Fluoro-2-deoxyglucose
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Portable Oxygen Concentrator Improvements to Physical Activity, Oxygen Usage, and Quality of Life in Chronic Obstructive Pulmonary Disease Patients Using Long-term Oxygen Therapy (POC-STEP)
Status: TERMINATED
Conditions: COPD
Interventions: DEVICE: Portable Oxygen Concentrator (POC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Negative Pressure Ventilation to Support Failing Fontan Physiology
Status: COMPLETED
Conditions: Failing Fontan Physiology|Pediatric Congenital Heart Disease
Interventions: DEVICE: Hayek RTX ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Radiofrequency Ablation in Treating Patients With Liver Cancer (Hepatocellular Carcinoma)
Status: WITHDRAWN
Conditions: Carcinoma, Hepatocellular
Interventions: PROCEDURE: radiofrequency ablation|PROCEDURE: laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De Oorzaak: Citizen Science Project on the Impact of Environmental Noise
Status: ENROLLING_BY_INVITATION
Conditions: Noise Exposure|Sleep|Hyperacusis
Interventions: DIAGNOSTIC_TEST: Sleep study|DIAGNOSTIC_TEST: stress-related biomarkers and microbiome composition will be assessed using saliva samples|DIAGNOSTIC_TEST: Audiological tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pegylated Liposomal Doxorubicin (Caelyx(R)) as Monotherapy in Elderly Patients With Locally Advanced and/or Metastatic Breast Cancer (Study P05059)
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: DRUG: Caelyx (pegylated liposomal doxorubicin; SCH 200746)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: 1 gram Tranexamic Acid (TXA)|DRUG: 2 grams TXA|DRUG: 0.9% Sodium Chloride injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
Status: COMPLETED
Conditions: Persian Gulf Syndrome
Interventions: DRUG: Carnosine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Early Steroid Withdrawal and Long-Term Steroid Maintenance Therapy in Kidney Transplant Patients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: tacrolimus|DRUG: CellCept|DRUG: steroids (methylprednisone or prednisone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Combination of Temsirolimus and Bevacizumab in Patient With Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: Temsirolimus|DRUG: Bevacizumab|DRUG: Sunitinib|DRUG: Interferon alpha-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Eribulin in Combination With HP Neoadjuvant Therapy in Patients With for HER2-Positive BC
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: Eribulin mesylate injection、Pertuzumab、Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
Status: RECRUITING
Conditions: Anesthesia, Epidural|Hypotension
Interventions: DIAGNOSTIC_TEST: ClearSight HPI Monitoring system|DIAGNOSTIC_TEST: Standard of Care Blood Pressure Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Profiling Program of Cancer Patients With Sequential Tumor and Liquid Biopsies (PLANET)
Status: RECRUITING
Conditions: Advanced / Metastic Solid Tumors|Glioblastoma|Chronic Leukemia Lymphocytic
Interventions: BIOLOGICAL: Blood and tumor samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of a Digital Health Education on Self-Foot Care and Quality of Life Among Patients With Diabetes
Status: NOT_YET_RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: BEHAVIORAL: Diabetes Self-Management Education (DSME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Percutaneous Screw Fixation for Acute Scaphoid Fractures Through K-wire-assisted Reduction and Maintenance
Status: COMPLETED
Conditions: Hand|Wrist|Wounds and Injuries
Interventions: PROCEDURE: Percutaneous screw fixation through K-wire-assisted reduction and maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ASP1941 in Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: ipragliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect and Safety of Benaglutide or Metformin in Patients With Simple Obesity Who Have Inadequate Weight Control
Status: UNKNOWN
Conditions: Obesity; Drug
Interventions: DRUG: Metformin|DRUG: Benaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Vancomycin vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection
Status: RECRUITING
Conditions: Clostridioides Difficile Infection
Interventions: DRUG: Oral Vancomycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adenosine Testing to DEtermine the Need for Pacing Therapy
Status: COMPLETED
Conditions: Syncope
Interventions: DEVICE: Pacemaker implantation (Medtronic)|DEVICE: Pacemaker implantation (Medtronic)|DEVICE: Implantable Loop Recorder (Medtronic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One Pass thalamIc aNd subthalamIc stimulatiON
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: Vercise™ Deep Brain Stimulation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Self-monitoring on Regulation of the Sleep-wake Cycle to Reduce Relapse of Depression After Discharge
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Circadian Reinforcement Therapy|BEHAVIORAL: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supracrestal Tissue Attachment Dimensions & Peri-implant Health
Status: RECRUITING
Conditions: Dental Implant Placement
Interventions: PROCEDURE: Bone level-driven placement|PROCEDURE: Biological width-driven placement guidelines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan in Treating Patients With Solid Tumors or Lymphoma Who Have Abnormal Liver or Kidney Function or Who Have Received Radiation Therapy to the Pelvis
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance
Status: RECRUITING
Conditions: Cardiac Output, Low|Cardiac Output, High|Perfusion; Complications
Interventions: DRUG: Epinephrin|DRUG: Norepinephrine|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Peptide Targets for Glioblastoma Against Novel Cytomegalovirus Antigens
Status: TERMINATED
Conditions: Glioblastoma|Glioblastoma Multiforme
Interventions: DRUG: 5-day TMZ|DRUG: 21-day TMZ|BIOLOGICAL: PEP-CMV: Component A|DRUG: Tetanus-Diphtheria booster|DRUG: Tetanus Pre-Conditioning|BIOLOGICAL: PEP-CMV: Component B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BI-1206 in Combination With Rituximab in Subjects With Indolent B-Cell Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Indolent B-Cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: BI-1206
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Pericapsular Nerve Group Block and Lateral Femoral Cutaneous Nerve Block for Pediatric Hip Surgeries
Status: RECRUITING
Conditions: Pericapsular Nerve Group Block
Interventions: PROCEDURE: Caudal epidural analgesia|PROCEDURE: Ultrasound-guided Combined Pericapsular Nerve Group Block|PROCEDURE: Ultrasound-guided Lateral Femoral Cutaneous Nerve Block|DRUG: Fentanyl|DRUG: Morphine|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gastrointestinal Endoscopy in Patients With Prothrombotic Conditions: THE ENDOHEM REGISTRY
Status: COMPLETED
Conditions: Gastrointestinal Bleeding|Cardiovascular Complication|Anticoagulants; Circulating, Hemorrhagic Disorder|Gastrointestinal Endoscopy
Interventions: PROCEDURE: Gastrointestinal endoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|E-cigarettes
Interventions: DEVICE: E-cigarette|OTHER: Sham|DRUG: Hyperpolarized 3-Helium|DRUG: Gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comprehensive Lifestyle Modification for Patients With Hypertension and Metabolic Syndrome: a Multicenter Randomized Controlled Trial
Status: COMPLETED
Conditions: Hypertension|Metabolic Syndrome
Interventions: BEHAVIORAL: Comprehensive Lifestyle Modification|BEHAVIORAL: Standard Lifestyle Modification / modified DASH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strategy for Maintaining Partial Neuromuscular Blocking Adequate for Motor Evoked Potential During Neurosurgery
Status: COMPLETED
Conditions: Brain Surgery With Motor Evoked Potential Monitoring|Spine Surgery With Motor Evoked Potential Monitoring
Interventions: OTHER: TOF count guided adjustment|OTHER: T1/ T0 guided adjustment|OTHER: T2/ T0 guided adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: The Value of Adding Group Education (DESMOND Method) to the Standard Primary Care Education Practices in Changing Glycemic Control and Self-care Practices in Adults With Type II Diabetes Mellitus: A Randomized Controlled Intervention Study.
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Group education session by DESMOND Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity
Status: COMPLETED
Conditions: Dental Prophylaxis and Implant Surgery
Interventions: DRUG: 0.2% w/v Chlorhexidine digluconate|DRUG: Sodium fluoride toothpaste (Aquafresh Mild & Minty)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: International ALLIANCE Study of Therapies to Prevent Progression of COVID-19
Status: UNKNOWN
Conditions: COVID19
Interventions: DIETARY_SUPPLEMENT: Vitamin C|DRUG: Hydroxychloroquine|DRUG: Azithromycin|DIETARY_SUPPLEMENT: Zinc Citrate|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antioxidant Therapy to Reduce Inflammation in Sickle Cell Disease
Status: COMPLETED
Conditions: Anemia, Sickle Cell
Interventions: DRUG: alpha-lipoic acid and acetyl-L-carnitine|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liraglutide in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Overweight
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Organ-preserving Management in Patients With Complete or Near-complete Tumour Response After Preoperative Radio(Chemo)Therapy for Rectal Cancer
Status: RECRUITING
Conditions: Rectal Neoplasms|Rectal Cancer
Interventions: RADIATION: Preoperative Radio(Chemo)Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
Status: RECRUITING
Conditions: Acetaminophen|Drug Overdose|Acetaminophen Overdose|Acetaminophen Poisoning|Drug-induced Liver Injury|Liver Failure|Liver Toxicity
Interventions: DRUG: Intravenous infusion of N-acetylcysteine|DRUG: Intravenous infusion of Fomepizole (4-MP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Measuring Aided Language Development
Status: NOT_YET_RECRUITING
Conditions: Down Syndrome|Cerebral Palsy|Apraxia of Speech|Speech Sound Disorder|Speech Disorders in Children|Speech and Language Disorder
Interventions: BEHAVIORAL: AAC Generative Language Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Maternal & Infant Morbidity and Mortality
Status: NOT_YET_RECRUITING
Conditions: Preg Complications: Hemorrhagic|Infant, Premature, Diseases|Preg Complications: Hemorrhagic Intervillous of Placenta|Preg Complications: Bleeding From Female Genital Tract|Preg Complic - Malig Hypertension and / or Reason for Care During Childbirth
Interventions: OTHER: Pregnant Women
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Determine the Effects of Deodorant, Antiperspirant and Washing on the Pharmacokinetics of 2% Testosterone MD Lotion
Status: COMPLETED
Conditions: Hypogonadism
Interventions: DRUG: Testosterone MD-Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Corneal Staining and Physiological Compromise After Eight Hours of Soft Contact Lens Wear
Status: COMPLETED
Conditions: Contact Lens-induced Corneal Fluorescein Staining
Interventions: DEVICE: ReNu Multiplus multipurpose disinfecting solution|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer
Status: UNKNOWN
Conditions: Bladder Cancer|Cervical Cancer|Colorectal Cancer|Endometrial Cancer|Gastrointestinal Complications|Long-term Effects Secondary to Cancer Therapy in Adults|Ovarian Cancer|Prostate Cancer|Radiation Toxicity|Sarcoma|Testicular Germ Cell Tumor|Vaginal Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: gastrointestinal complications management/prevention|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Effect of Nefopam With Propacetamol for Postoperative Pain After Thyroidectomy
Status: COMPLETED
Conditions: Thyroidectomy|Pain
Interventions: DRUG: Nefopam|DRUG: Propacetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Surface EKG Signals to Identify Myocardial Dysfunction in Patients at Risk for Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: MyoVista device|DEVICE: Computed tomographic coronary angiography|DEVICE: Transthoracic Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Oral MRT-2359 in Selected Cancer Patients
Status: RECRUITING
Conditions: NSCLC|SCLC|High Grade Neuroendocrine Cancer|DLBCL|L-MYC and N-MYC Amplified Solid Tumors|NSCLC With High or Low L-MYC or N-MYC Expression|HR-positive, HER2-negative Breast Cancer|Prostate Cancer
Interventions: DRUG: Oral MRT-2359|DRUG: Oral MRT-2359|DRUG: Oral MRT-2359|DRUG: Oral MRT-2359|DRUG: Oral MRT-2359|DRUG: Oral MRT-2359
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alirocumab in Patients on a Stable Dialysis Regimen
Status: UNKNOWN
Conditions: Hemodialysis|Peritoneal Dialysis|Hypercholesterolemia|Atherosclerotic Disease
Interventions: DRUG: Alirocumab 150 MG/ML [Praluent]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Echocardiographic Standards and Sub-Saharian Africans (SSA) Migrants' in New Aquitaine Region
Status: UNKNOWN
Conditions: Diagnosis
Interventions: DIAGNOSTIC_TEST: Echocardiography measures on SSA participants
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics From Single Dose of Intramuscular (IM) and Subcutaneous (SC) Donepezil (GB-5001) Injections Versus Donepezil Oral Tablet (Aricept®) in Healthy Male Volunteers
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: GB-5001A|DRUG: GB-5001D|DRUG: Oral cohort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficiency of Postoperative Interferon-alpha Treatment in p48 Positive Patients With Hepatocellular Carcinoma
Status: WITHDRAWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: interferon-alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Different Bed-Head Angles on the Haemodynamic Parameters of Intensive Care Patients Lying in the Supine Position
Status: COMPLETED
Conditions: Thyroidectomy|Colon Surgery|Cholecystectomy|Inguinal Hernia
Interventions: OTHER: the bed-head was raised to an angle of 0, 20, 30 and 45 degrees
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ATX-MS-1467 in Patients With Relapsing Forms of Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: BIOLOGICAL: ATX-MS-1467
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Surface Area Reduction Using MolecuLight Imaging Device
Status: UNKNOWN
Conditions: Wound|Wound Infection
Interventions: DEVICE: MolecuLight i:X™ Imaging Device|PROCEDURE: Wound care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NAD Augmentation in Diabetes Kidney Disease
Status: RECRUITING
Conditions: Type2diabetes|Diabetic Kidney Disease
Interventions: DRUG: Investigational Product - MIB 626|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Iron Therapy as an Adjunct to Epoetin Alfa in the Anemia of Cancer Chemotherapy
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Sodium ferric gluconate, ferrous sulfate, standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rhBMP-2/CRM/CD HORIZON® Spinal System Pilot Study (2-Level)
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: rhBMP-2/CRM/CD HORIZON® Spinal System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor Cell Vaccines With ISCOMATRIX Adjuvant and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers and Malignant Pleural Mesotheliomas
Status: TERMINATED
Conditions: Mesolthelioma|Esophageal Cancer|Lung Cancer|Thoracic Sarcomas|Thymoma
Interventions: DRUG: Celebrex|BIOLOGICAL: Tumor cell vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metatranscriptomic Next Generation Sequencing in First Trimester Trophoblast With Increased Fetal Nuchal Translucency (METAHCN)
Status: RECRUITING
Conditions: Increased Nuchal Translucency in the First Trimester of Pregnancy
Interventions: BIOLOGICAL: Metatranscriptomic|DIAGNOSTIC_TEST: Specific microbiologic diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adenosine Versus Verapamil for Management of Supraventricular Tachycardia Post- Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Supraventricular Tachycardia
Interventions: DRUG: adenosine|DRUG: verapamil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vicriviroc, a CCR5 Inhibitor, Added to an Optimized Antiretroviral Therapy for Previously Treated HIV (VICTOR-E2) (Study P04285
Status: WITHDRAWN
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome
Interventions: DRUG: Vicriviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenously (IV) Infused or Subcutaneously (SC) Injected Risankizumab in Healthy Adult Participants in China
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Risankizumab|DRUG: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Wearables for the Bladder: an In-home Treatment Feasibility Pilot Study
Status: RECRUITING
Conditions: Multiple Sclerosis|Urinary Bladder, Overactive
Interventions: DEVICE: WeB|OTHER: Standard pelvic floor physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of MK-1496 in Patients With Advanced Solid Tumor (MK-1496-002 AM 4)(COMPLETED)
Status: COMPLETED
Conditions: Neoplasms|Malignant
Interventions: DRUG: MK-1496|DRUG: MK-1496
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers
Status: COMPLETED
Conditions: Pre-eclampsia|Intra-uterine Growth Restriction
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continued HER2 Suppression With Lapatinib Plus Trastuzumab Versus Trastuzumab Alone
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: Lapatinib|BIOLOGICAL: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Transcranial Direct Current Stimulation on Motor Performance in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: HD-tDCS 2 mA|DEVICE: HD-tDCS 1.5 mA|DEVICE: HD-tDCS sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment
Status: RECRUITING
Conditions: Uveitis|Uveitis, Posterior|Uveitis, Anterior|Uveitis, Intermediate
Interventions: DRUG: Yutiq 0.18 MG Drug Implant|OTHER: Sham Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Third Line Antiretroviral Treatment Optimization in Sub-Saharan Africa
Status: UNKNOWN
Conditions: HIV Infection
Interventions: BEHAVIORAL: adherence reinforcement|DRUG: Antiretroviral Therapy Darunavir/r + Raltegravir + 2 NRTIs (as chosen by the investigators)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: White Button Mushroom Extract in Treating Patients With Recurrent Prostate Cancer After Local Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: white button mushroom extract|OTHER: flow cytometry|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|OTHER: gas chromatography-mass spectrometry|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heart Rate Variability Biofeedback as Adjunctive Therapy to Self-help CBT-I
Status: UNKNOWN
Conditions: Insomnia
Interventions: BEHAVIORAL: HRV biofeedback training and self-help CBT-I|BEHAVIORAL: Self-help CBT-I only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Complications in Head and Neck Cancer Patients
Status: UNKNOWN
Conditions: Head-and-neck Cancer
Interventions: DIAGNOSTIC_TEST: Ultrasonography|DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: Neuro Psychological Assessment Battery|DIAGNOSTIC_TEST: Questionaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Nitisinone in Arm A|DRUG: Tolbutamide|DRUG: Metoprolol|DRUG: Chlorzoxazone|DRUG: Furosemide|DRUG: Nitisinone in Arm B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitochondrial Myopathies|Mitochondrial Pathology|Mitochondrial DNA Mutation|Mitochondrial Diseases|Mitochondrial DNA Deletion|Mitochondrial DNA Depletion|Mitochondrial Metabolism Defect|Mitochondrial Complex I Deficiency
Interventions: DRUG: Elamipretide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Temsirolimus|DRUG: Cetuximab|DRUG: Cisplatin|DEVICE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intradialytic High-Intensity Interval Training in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease|Exercise, Compulsive
Interventions: OTHER: High Intensity Interval Exercise Training|OTHER: Moderate Intensity Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GP VS TP in the Treatment of Advanced Nasopharyngeal Carcinoma in Northwest China
Status: COMPLETED
Conditions: Nasopharyngeal Squamous Cell Carcinoma|Toxicity Due to Radiotherapy
Interventions: DRUG: gemcitabine and cisplatin|DRUG: docetaxel and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating Three Fixed Doses of Paliperidone Extended-Release (ER) Tablets and Olanzapine in the Treatment of Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Once Daily Doses of AQW051 on Cognition, in Stable Schizophrenia Patients
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: AQW051|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Facial Affect Sensitivity Training for Young Children With Callous-unemotional Traits
Status: RECRUITING
Conditions: Affective Symptoms|Empathy
Interventions: BEHAVIORAL: Facial Affect Sensitivity Training (FAST)|BEHAVIORAL: Implicit Gaze Training task (Active control condition)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Active Surveillance for the Treatment of Low-Risk Basal Cell Carcinoma in Elderly Patients
Status: NOT_YET_RECRUITING
Conditions: Skin Basal Cell Carcinoma
Interventions: OTHER: Best Practice|OTHER: Educational Activity|OTHER: Patient Observation|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF SHR-A1904 IN SUBJECTS WITH ADVANCED SOLID TUMORS
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: SHR-A1904
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of the Circadian System in Binge Eating Disorder
Status: RECRUITING
Conditions: Binge-Eating Disorder|Circadian Rhythm Disorders
Interventions: DIETARY_SUPPLEMENT: Melatonin (3hrs before DLMO)|DIETARY_SUPPLEMENT: Placebo (3hrs before DLMO)|DEVICE: Morning light version 1|DEVICE: Morning light version 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparative Efficacy and Safety Study Between Two Silver Containing Dressings In Post-Op Wound Healing
Status: TERMINATED
Conditions: Surgical Wound
Interventions: DEVICE: BCT Silver Bandage|DEVICE: Aquacel® Ag. Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vertebral Body Tethering Outcomes for Pediatric Idiopathic Scoliosis
Status: UNKNOWN
Conditions: Idiopathic Scoliosis
Interventions: DEVICE: Anterior Vertebral Tether
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers
Status: RECRUITING
Conditions: Malignant Rhabdoid Tumor|Rhabdoid Tumor of the Kidney|Epithelioid Sarcoma|Chordoma (Poorly Differentiated or De-differentiated)|Atypical Teratoid/Rhabdoid Tumor|Other INI1 Negative Tumors (With PI Approval)|Other SMARCA4-deficient Malignant Tumors (With PI Approval)
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer|Advanced Solid Tumor
Interventions: DRUG: Larotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sensory Evidence and Expectations in Pain Processing
Status: COMPLETED
Conditions: Experimental Pain in Healthy Human Participants
Interventions: DEVICE: Painful stimulation using a laser device (DEKA Stimul 1340, Calenzano, Italy)|DEVICE: Visual cueing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1
Status: COMPLETED
Conditions: Heroin Dependence|Morphine Dependence|Substance Withdrawal Syndrome
Interventions: DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab in HER2-positive Biliary Tract Cancer
Status: COMPLETED
Conditions: Cholangiocarcinoma|Biliary Tract Cancer|HER-2 Protein Overexpression|HER-2 Gene Amplification
Interventions: DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Injectable SHR-A1811 in Combination With Pyrotinib or SHR-1316 in Subjects With Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: SHR-A1811 & Pyrotinib/SHR-A1811 & SHR-1316
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Plasma (PRP) as a Treatment for ACHILLES Tendon Tears
Status: COMPLETED
Conditions: Achilles Tendon Tear
Interventions: BIOLOGICAL: PRGF|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Heterologous and Homologous COVID-19 Vaccination
Status: COMPLETED
Conditions: Healthy Adult Volunteers
Interventions: BIOLOGICAL: ChAdOx1-nCov-19 (Astra-Zeneca)|BIOLOGICAL: SARS-CoV-2 messenger RNA-1273 (Moderna) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Pioglitazone as an Anti-inflammatory for the Treatment of Cystic Fibrosis (CF) Lung Disease
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroids in Bilateral Total Knee Replacement
Status: COMPLETED
Conditions: Postoperative Inflammatory Response
Interventions: DRUG: Hydrocortisone|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacodynamic Blood Characteristics of ICP-332 in Patients With Moderate to Severe Atopic Dermatitis
Status: RECRUITING
Conditions: Moderate to Severe Atopic Dermatitis
Interventions: DRUG: ICP-332|DRUG: ICP-332 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess PK/PD Character, Safety/Tolerability of CKD-519 New Formulation in Healthy Male Subject.
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: CKD-519 50mg 2Tabs.|DRUG: CKD-519 100mg 1Tab.|DRUG: CKD-519 100mg 1Cap.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Therapy for the Treatment of Ischemic Heart Disease
Status: UNKNOWN
Conditions: Refractory Angina Pectoris
Interventions: DEVICE: Cardiac Extracorporeal Shockwave Therapy generator (Cardiospec)|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Optimal Strategy for the Management of ASCUS Cytology in Health Care Services of Medellin, Colombia
Status: COMPLETED
Conditions: Cervical Abnormalities|Cervical Intraepithelial Neoplasia Grade 2/3|Cervical Cancer
Interventions: DEVICE: HPV test|PROCEDURE: COLPOSCOPY|DEVICE: cytology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Induction, Consolidation and Intensification Therapy for Patients Younger Than 66 Years With Previously Untreated CD33 Positive Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: FLAIMy - Fluda, Ida, Ara-C, Mylotarg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label, Multiple-Dose, Non-Randomized Study to Assess Drug-Drug Interactions of Proellex® in Female Subjects
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: Proellex|DRUG: CYP1A2 probe|DRUG: CYP2C9 probe|DRUG: CYP2C19 probe|DRUG: CYP2D6 probe|DRUG: CYP3A4 probe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Meditation for Dementia Caregivers Major Depressive Disorder in Family Dementia Caregivers
Status: COMPLETED
Conditions: Mentalizing Imagery Therapy|Relaxation Recording
Interventions: BEHAVIORAL: Mentalizing Imagery Therapy|BEHAVIORAL: Relaxation cd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of GC33 (RO5137382) in Patients With Advanced or Metastatic Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Placebo|DRUG: GC33
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT