pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of SANGUINATE™ In the Treatment of Sickle Cell Disease Patients With Vaso-Occlusive Crisis
Status: COMPLETED
Conditions: Anemia, Sickle Cell
Interventions: DRUG: SANGUINATE|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Diarrhea-predominant Irritable Bowel Syndrome (IBS-D) With LACTEOL® 340 mg
Status: TERMINATED
Conditions: Diarrhea-predominant Irritable Bowel Syndrome
Interventions: DRUG: LACTEOL® 340 mg|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Myocardial Protection
Status: RECRUITING
Conditions: Cardiac Surgery|Cardiopulmonary Bypass
Interventions: DRUG: Dexmedetomidine|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sintilimab Plus Hypofractionated Radiotherapy for MSI-H/dMMR Rectal Cancer
Status: RECRUITING
Conditions: Anti-PD-1 Antibody|Radiotherapy|Rectal Cancer|MSI-H|Mmr Deficiency
Interventions: DRUG: Sintilimab|RADIATION: Hypofractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely
Status: UNKNOWN
Conditions: Hypoxia|Altitude Sickness|Tolerance
Interventions: OTHER: Graded exercise testing|OTHER: Resting testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Application of Integrated Proteomic and Serum Metabolomic Analysis in Assessing the Efficacy and Prognosis of TACE Combined With Targeted Immunotherapy in Unresectable Hepatocellular Carcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Hepatocellular Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Virtual Reality (VR) Versus Conventional Vestibular Rehabilitation and Progressive Muscle Relaxation (PMR) to Improve Balance and Stress Among Patients of Persistent Postural Perceptual Dizziness (PPPD).
Status: NOT_YET_RECRUITING
Conditions: Persistent Postural Perceptual Dizziness
Interventions: OTHER: progressive muscle relaxation (PMR) technique and vestibular rehabilitation exercises|OTHER: virtual reality (VR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Change in Brain Metabolism and Cognitive Function by Aripiprazole
Status: COMPLETED
Conditions: Antipsychotics|Cognition|Brain Metabolism|Dopamine Receptor Occupancy
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Status: RECRUITING
Conditions: Brain Cancer|Brain Metastases|Melanoma|Lung Cancer|Breast Cancer|HER2-positive Breast Cancer|Colorectal Cancer|Gastrointestinal Cancer|SRS|SRT|Whole Brain Radiation|Stereotactic Radiation|AGuIX|Nanoparticle|Cystic|Brain Tumor
Interventions: RADIATION: Stereotactic Radiation|DRUG: AGuIX gadolinium-based nanoparticles|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Topical Skin Adhesive or Sutures for Closure Due to Episiotomy or Perineal Tears Following Childbirth
Status: COMPLETED
Conditions: Episiotomy|Perineal Tear
Interventions: DEVICE: High Viscosity DERMABOND
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Adaptive Radiotherapy for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Paranasal Sinus Cancer|Oropharynx Cancer|Oral Cavity Cancer|Nasopharynx Cancer|Larynx Cancer|Hypopharynx Cancer
Interventions: RADIATION: Adaptive Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Hug-up Test: A New, Sensitive Diagnostic Test for Supraspinatus Tears
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: DIAGNOSTIC_TEST: The hug-up test|DIAGNOSTIC_TEST: EC test|DIAGNOSTIC_TEST: FC test|DIAGNOSTIC_TEST: Neer impingement sign|DIAGNOSTIC_TEST: Hawkins-Kennedy impingement sign|DIAGNOSTIC_TEST: diagnostic arthroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Dog-assisted Therapy to Reduce Burnout Among Professionals Working in a School for Special Education
Status: UNKNOWN
Conditions: Occupational Groups|Work Related Stress
Interventions: BEHAVIORAL: Dog-assisted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Augmentation of Volatile Biomarkers of Oesophageal and Gastric Adenocarcinoma From the Tumour Lipidome
Status: NOT_YET_RECRUITING
Conditions: Breath Test|Oesophageal Cancer|Gastric Cancer|Augmentation|Diagnoses Disease
Interventions: DIETARY_SUPPLEMENT: Oral Stimulant Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimal Effect-site Concentration of Remifentanil for Inhibiting Response to Laryngeal Mask Airway (LMA) Removal
Status: COMPLETED
Conditions: Respiratory Complication
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of Peru-15-pCTB in Healthy Adult Subjects
Status: COMPLETED
Conditions: Gastroenteritis Escherichia Coli
Interventions: DRUG: Ciprofloxacin|BIOLOGICAL: Peru-15-pCTB|OTHER: Sodium bicarbonate/Ascorbic Acid/Aspartame Buffer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: dCBTi for Adults With ADHD
Status: UNKNOWN
Conditions: Insomnia
Interventions: BEHAVIORAL: Sleep Hygiene and Self-Monitoring Control|BEHAVIORAL: dCBTi-ADHD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cognitive Behavioral Therapy on Brain Serotonin Activity in People With Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: ADAM SPECT plus Cognitive Therapy|DRUG: ADAM SPECT plus No Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ozonated Water Irrigation as an Adjunct to Periodontal Therapy
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: OTHER: salin irrigation|OTHER: ozonated water irrigation|OTHER: chlorhexidine irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hypocholesterolemic Effect of a Phytosterol-enriched Spreadable Cream Prepared With Virgin Olive Oil
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Enriched spread|DIETARY_SUPPLEMENT: Control spread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PT-led Triage for Patients With Hip o Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis|Hip Osteoarthritis
Interventions: OTHER: Assessment by PT/Orth surgeon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of a Double-reading Animated Film (Child, Parents) in Preoperative on the Anxiety of Children Upon Arrival at the Operating Room
Status: UNKNOWN
Conditions: Anxiety|Surgery|Pediatric ALL
Interventions: OTHER: Animated film
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Clinical Activity of a Sequential Dose of REGN846 on Refractory Pruritus in Patients With Atopic Dermatitis
Status: TERMINATED
Conditions: Pruritus|Atopic Dermatitis
Interventions: DRUG: REGN846
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pannus Assistance Needed for Obstetric Ultrasound Studies
Status: COMPLETED
Conditions: Obesity Complicating Childbirth|Fetal Anomaly
Interventions: DEVICE: traxi® Panniculus Retractor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Opira AIOL in Comparison to Commercial IOLs in Patients Undergoing Cataract Surgery
Status: UNKNOWN
Conditions: Cataract
Interventions: DEVICE: Cataract Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The ROTAtional-USE of Interface STUDY
Status: RECRUITING
Conditions: Pressure Ulcer|Noninvasive Positive Pressure Ventilation|Acute Hypercapnic Respiratory Failure
Interventions: PROCEDURE: Protocolized rotational use of interfaces|PROCEDURE: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sex Differences in the Vascular Effects of E-cigarette Use
Status: RECRUITING
Conditions: E-cigarette Use
Interventions: DRUG: Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor)|OTHER: Chronic estrogen exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Metastatic Non-small Cell Lung Cancer
Interventions: DRUG: Tislelizumab|DRUG: BGB-A445|DRUG: LBL-007|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: pemetrexed|DRUG: Paclitaxel|DRUG: Nab paclitaxel|DRUG: BGB-15025
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Smoking Cessation in Hospitalized Cardiac Patients
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Financial Incentives (FI) and Nicotine Replacement Therapy (NRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of ATB-346 Versus Placebo in Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: ATB-346 low dose|OTHER: Placebo|DRUG: ATB-346 mid-dose|DRUG: ATB-346 standard dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludeoxyglucose F 18 Positron Emission Tomography and Magnetic Resonance Perfusion Imaging in Patients With Neurofibromatosis 1 and Plexiform Neurofibroma
Status: TERMINATED
Conditions: Neurofibromatosis Type 1|Precancerous Condition
Interventions: RADIATION: fludeoxyglucose F 18|RADIATION: gadopentetate dimeglumine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Proteus Sustained Behavior Change Study
Status: WITHDRAWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: Proteus Sustained Behavior Change system|DRUG: Regularly prescribed diabetes medicines (metformin, sulfonylureas, thiazolidinediones, DPP-IV inhibitors, alpha-glucosidase inhibitors)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Hepatitis C Infection by Ledipasvir/Sofosbuvir in Naïve Children
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Ledipasvir-Sofosbuvir 90 Mg-400 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial To Assess Switching From Ropinirole, Pramipexole Or Cabergoline To The Rotigotine Transdermal System In Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Loss for Uncontrolled Asthma Associated With Elevated BMI
Status: RECRUITING
Conditions: Asthma|Obesity
Interventions: DIETARY_SUPPLEMENT: Counterweight Plus|OTHER: Usual asthma care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PEFCATII Expanded Safety and Feasibility Study of the FARAPULSE Endocardial Multi Ablation System to Treat Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: FARAPULSE Endocardial Multi Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination
Status: TERMINATED
Conditions: Smallpox
Interventions: BIOLOGICAL: ACAM1000|BIOLOGICAL: vaccinia virus (calf lymph) smallpox vaccine: Dryvax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking Among Homeless Adults
Status: COMPLETED
Conditions: Alcohol Use Disorder|Treatment|Homelessness
Interventions: BEHAVIORAL: EMA + App/Treatment Messages
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection and Treatment of Somatic Disease in Patients With Severe Mental Disease
Status: UNKNOWN
Conditions: Ischemia|Cardiac Insufficiency|Diabetes Mellitus, Type 2|Hypertension|Hypercholesterolemia|Severe Mental Disorder
Interventions: OTHER: Screening|OTHER: Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparison of Adenoma Detection Miss Rates at Colonoscopy Associated With Different Withdrawal Times
Status: COMPLETED
Conditions: Adenoma and/or Adenocarcinoma|Adenoma
Interventions: PROCEDURE: 3-minute withdrawal time|PROCEDURE: 6-minute withdrawal time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Immune Globulin Subcutaneous (Human), 20% Solution (IGSC, 20%) in Japanese Participants With Primary Immunodeficiency Diseases (PID)
Status: COMPLETED
Conditions: Primary Immunodeficiency Diseases (PID)
Interventions: BIOLOGICAL: Immune Globulin Intravenous (IGIV)|BIOLOGICAL: Immune Globulin Subcutaneous, 20% Solution (IGSC, 20%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Mellitus and Periodontitis and Vitamin D Supplementation
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2 With Periodontal Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D3K2|OTHER: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hypnosis, Self-hypnosis and Weight Loss in Obese Patients
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: dietetic counselling|BEHAVIORAL: Hypnosis and self-hypnosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ro Plus CHOEP as First Line Treatment Before HSCT in Young Patients With Nodal Peripheral T-cell Lymphomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral T-cell Lymphomas (PTCL)|PTCL-NOS|Angioimmunoblastic T-cell Lymphoma (AITL)|ALK- Anaplastic Large Cell Lymphoma (ALCL)|Nodal Peripheral T-Cell Lymphoma of T Follicular Helper Cell Origin
Interventions: DRUG: Ro-CHOEP-21 (PHASE I)|DRUG: Ro-CHOEP-21 (PHASE II)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mapatumumab in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Mapatumumab|DRUG: Placebo|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumour DNA and Urine Tumor DNA Detection of Minimal Residual Disease in Locally Advanced Upper Tract Urothelial Carcinoma With Radical Nephroureterectomy: A Cohort Study
Status: RECRUITING
Conditions: Muscle Invasive Upper Tract Urothelial Carcinoma
Interventions: DRUG: Adjuvant chemotherapy|DRUG: adjuvant immunotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodality Evaluation of LAA Leaks Arising After Incomplete LAAC: Insights From the LAA-Leak Registry
Status: COMPLETED
Conditions: Left Atrail Appendage Closure: Peri-device Leaks
Interventions: OTHER: leak closure with either detachable embolization coils, vascular plugs/CSO, or RFA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem Cells (CardiALLO)
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure, Systolic
Interventions: COMBINATION_PRODUCT: CardiALLO™ Human Allogenic Culture-expanded Bone marrow-derived Mesenchymal Stem Cells (hMSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Version of CRAFT Compared to Self-Directed CRAFT Delivery and Non-intervention: a Three-armed RCT
Status: TERMINATED
Conditions: Addiction|Substance Use Disorder|Alcohol Use Disorder|Substance- Related Disorder
Interventions: BEHAVIORAL: Group CRAFT|BEHAVIORAL: Self-Directed CRAFT Delivery|OTHER: Non-intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Incisional Hernia After Elective Open Abdominal Aortic Aneurysm (AAA) Repair
Status: TERMINATED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Ultrapro® Mesh implantation|OTHER: Standard wound closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Overall and Disease Specific Survival in Patients With Confirmed MEN1 With or Without PNET (Pancreatic Neuroendocrine Tumors)
Status: ACTIVE_NOT_RECRUITING
Conditions: Genetic Mutation|MEN1
Interventions: OTHER: Chart Review|BEHAVIORAL: Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plantar Sensation, Balance, Risk of Falling and Gait in Patients With Schizophrenia
Status: COMPLETED
Conditions: Plantar Sensation|Balance; Distorted|Fall|Gait Disorders, Neurologic
Interventions: OTHER: Correlation / Observational
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effects of INP on Peripheral Circulation in Dialysis Patients and Patients With PAD and Leg Ulcers
Status: TERMINATED
Conditions: Renal Disease|Peripheral Arterial Disease|Arterial Leg Ulcers
Interventions: DEVICE: FlowOx™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of a Vascular Prosthesis as an Above-Knee Bypass Graft in Patients With PAD
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease|Peripheral Vascular Disease
Interventions: BIOLOGICAL: HAV implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Telehealth Versus In-person Intervention for Binge Eating
Status: COMPLETED
Conditions: Binge Eating
Interventions: BEHAVIORAL: Dialectical behavior therapy-informed group eating intervention protocol (telehealth)|BEHAVIORAL: Dialectical behavior therapy-informed group eating intervention protocol (in-person)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block in Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: routine rehabilitation treatment|PROCEDURE: Stellate ganglion block|DRUG: Lidocaine hydrochloride|PROCEDURE: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TMC435 in Combination With Pegylated Interferon Alp\Fa-2a and Ribavirin in Patients Infected With Genotype 1 Hepatitis C Virus Who Never Received Treatment
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: TMC435|DRUG: Ribavirin (R)|DRUG: PegIFNα-2a (P)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of CHR-2845 to Treat Haematological Diseases or Lymphoid Malignancies
Status: COMPLETED
Conditions: Hematological Disease|Lymphoid Malignancies
Interventions: DRUG: CHR-2845
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trail Of An Adjuvanted Inactivated H7N9 Influenza Vaccine
Status: UNKNOWN
Conditions: H7N9 Influenza
Interventions: BIOLOGICAL: 7.5μg H7N9 Vaccine|BIOLOGICAL: Phosphate Buffer Solution|BIOLOGICAL: Aluminum Hydroxide Adjuvant|BIOLOGICAL: 15μg H7N9 Vaccine|BIOLOGICAL: 30μg H7N9 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Ranolazine Acute Administration and Short Term Administration in Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Ranolazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies
Status: RECRUITING
Conditions: Abnormal Vaginal Flora|Clindamycin Vs Metronidazole|High Risk Pregnancies for Preterm Labor
Interventions: DRUG: Clindamycin|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect of Spinal Manipulation by Gender
Status: COMPLETED
Conditions: Mechanical Low Back Pain|Chronic Pain|Gender|Neuromuscular Subluxation of Joint
Interventions: OTHER: Spinal Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine|Chronic Migraine, Headache|Chronic Migraine Without Aura|Aura Migraine
Interventions: DRUG: TNX-1900|DRUG: Placebo Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Open Label, Multi-Center, Follow-on Study Examining the Long-Term Safety and Efficacy of Insulin VIAject™ in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: VIAject™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038)
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: Gefapixant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Muscle Mass in Patients Over the First Week of ICU Care: RCT
Status: UNKNOWN
Conditions: Critical Illness
Interventions: COMBINATION_PRODUCT: Combined cycle ergometry and bolus amino acid supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oxford Study of Prebiotics in Children
Status: UNKNOWN
Conditions: Behaviour
Interventions: DIETARY_SUPPLEMENT: Bimuno (BGOS)|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome|Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Secondary Acute Myeloid Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Daunorubicin|DRUG: Cytarabine|DRUG: Clofarabine|DRUG: Decitabine|OTHER: Observation|PROCEDURE: Allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerance, and Pharmacokinetic and Pharmacodynamic Profile Of 1 SR Formulation of EB-1020
Status: COMPLETED
Conditions: Normal, Healthy Volunteers
Interventions: DRUG: EB-1020 IR|DRUG: EB-1020 SR1|DRUG: EB-1020 SR2|DRUG: EB-1020 SR3|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Metformin in Combination With Standard Induction Therapy for Large B-cell Lymphoma (DLBCL)
Status: TERMINATED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Metformin|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PRENAYOGA: Exploratory Feasibility Study of Bi-weekly Pregnancy Yoga-based Sessions for Ethnic Minority Women
Status: COMPLETED
Conditions: Prenatal Stress|Pregnancy Related|Complementary
Interventions: BEHAVIORAL: PRENAYOGA - prenatal yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Rare Tumours
Interventions: DRUG: Sunitinib|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Placebo Controlled Study of Nolasiban to Improve Pregnancy Rates in Women Undergoing IVF/ICSI
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Nolasiban 900mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Ontamalimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Preoperative Antiseptic Solutions Alcohol Based in Abdominal Elective Surgeries
Status: TERMINATED
Conditions: Surgical Site Infection
Interventions: DRUG: Iodine Povacrylex 7 MG/ML / Isopropyl Alcohol 0.74 ML/ML|DRUG: Chlorhexidine Gluconate 20 MG/ML / Isopropyl Alcohol 0.7 ML/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Aesthetic Outcome of Running Cuticular Suture Distance (2mm vs 5mm)
Status: COMPLETED
Conditions: Suture|Dermatologic Surgery|Scar|Cosmetic Outcome
Interventions: PROCEDURE: Suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease
Status: ENROLLING_BY_INVITATION
Conditions: Parkinson Disease
Interventions: BIOLOGICAL: Autologous midbrain dopamine neurons
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Effect of Intranasal Calcitonin on Patients With Fractured Ribs
Status: TERMINATED
Conditions: Rib Fractures|Pain
Interventions: DRUG: Intranasal calcitonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: INHALATION WITH PEP DEVICE (Acapella Duet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Integrated Actionable Aging Assessment for Cancer Patients Pilot
Status: RECRUITING
Conditions: Breast Cancer|Hodgkin Lymphoma|Kidney Cancer|Leukemia|Lymphoid Leukemia|Multiple Myeloma|Myeloid Leukemia|Monocytic Leukemia|Prostate Cancer|Bladder Cancer
Interventions: OTHER: Assessment tool IA3-CP with SDoH|OTHER: Assessment tool IA3-CP without SDoH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Assessing the Safety and Ability of SG1002 to Overcome Deficits in Hydrogen Sulfide in Heart Failure Patients
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: SG1002|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Asthma Clinical Research Network (ACRN) Trial - Macrolides in Asthma (MIA)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: clarithromycin|DRUG: fluticasone propionate|DRUG: placebo clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Symbicort on HAT and HDAC in Sputum Macrophages of COPD
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Age Matched Healthy Volunteers (Non-smokers)
Interventions: PROCEDURE: Skin Prick Test|PROCEDURE: Impulse Oscillometry|PROCEDURE: Exhaled Nitric Oxide|PROCEDURE: Spirometry|PROCEDURE: Reversibility|PROCEDURE: Exhaled Breath Condensate|PROCEDURE: Sputum Induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: High Flow Nasal Cannula in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) HF-study
Status: UNKNOWN
Conditions: Patient Population Submitted to ERCP
Interventions: DEVICE: High Flow nasal cannula|DEVICE: Low Flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Novel Screening Tools For the Evaluation and Management of Malnourished Children in the Developing World
Status: COMPLETED
Conditions: Overweight, Obesity, Small for Gestational Age, Prematurity
Interventions: OTHER: Measurement of leptin and adiponectin obtained through blood sampling via venipuncture or finger/heelstick using novel screening tool
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fibrosis in Chronic and Delayed Myocardial Infarction
Status: RECRUITING
Conditions: Aortic Stenosis|Chemotherapy Induced Systolic Dysfunction|Carcinoid Syndrome
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI and 18F-AlF-FAPI PET-MR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Initiation of Continuous Glucose Monitoring in Adults With Type 2 Diabetes Treated With Basal Insulin, in Italy
Status: RECRUITING
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: DEVICE: FreeStyle Libre 2 Flash Glucose Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: EXtended Use of FOsfomycin for the Treatment of CYstitis in Primary Care
Status: TERMINATED
Conditions: Urinary Tract Infections
Interventions: DRUG: Fosfomycin|DRUG: Nitrofurantoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Relationship Between Stage of Diabetic Retinopathy and Retinal Blood Flow in Patients With IDDM During Euglycemic Clamp
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Insulin|Retina|Regional Blood Flow
Interventions: DRUG: Insulin|DRUG: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Vitamin D Supplementation in Obese Children
Status: COMPLETED
Conditions: Obesity, Pediatric|Obesity, Childhood|Obesity, Morbid|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Single-dose, Comparative Bioavailability Study of Two Formulations of Ursodiol 500mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ursodiol 500 MG|DRUG: Urso Forte 500Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Selective GlyT1 Inhibitor Bitopertin for Steroid-Refractory Diamond-Blackfan Anemia
Status: RECRUITING
Conditions: Steroid-refractory Diamond-Blackfan Anemia (DBA)
Interventions: DRUG: Bitopertin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Body-worn Multimodal Hand Hygiene System. Impact on Health-Care Associated Infections
Status: COMPLETED
Conditions: Nosocomial Infection
Interventions: DEVICE: Body worn alcohol gel dispenser|DRUG: 62% ethanol based hand cleanser|BEHAVIORAL: Educational component with regard to teaching CDC guidelines|BEHAVIORAL: Provider and group feedback
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women
Status: COMPLETED
Conditions: Alteration of Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Cereal|DIETARY_SUPPLEMENT: No breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Observational Study of Patients Using NovoMix® 30 or Levemir® for Treatment of Type 1 or Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30|DRUG: insulin detemir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Canagliflozin-Mealtime Insulin Rescue
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: canagliflozin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Intervention
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: BEHAVIORAL: Telehealth for opioid use disorder treatment delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of VLCKD in Metabolic Syndrome
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Non-alcoholic Fatty Liver Disease|Obesity|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: VLCKD diet with replacing meals|BEHAVIORAL: Hypocaloric mediterranean Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0727 Gemcitabine Hydrochloride and Erlotinib Hydrochloride With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Stage IV Pancreatic Cancer
Interventions: BIOLOGICAL: cixutumumab|DRUG: erlotinib hydrochloride|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rectal Prolapse With ODS. STARR vs LVR.
Status: COMPLETED
Conditions: Rectal Prolapse|Defecation Disorder|Rectocele; Female|Surgery
Interventions: PROCEDURE: STARR (Stapled Trans Anal Rectal Resection)|PROCEDURE: LVR (Laparoscopic Ventral Rectopexy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy Study of Pucotenlimab Combined With Neoadjuvant Chemotherapy in Advanced Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Endometrioid Endometrial Cancer
Interventions: DRUG: Pucotenlimab|DRUG: Carboplatin|DRUG: Paclitaxel|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Risk Factors for Autism Spectrum Disorders: A Case-Control Approach
Status: COMPLETED
Conditions: Autism|Autism Spectrum Disorder|Autistic Disorder|Pregnancy Related|Diet, Healthy|Diet; Deficiency|Folate Deficiency|Folic Acid Deficiency|Folic Acid Overdose
Interventions: OTHER: Survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multimodal Imaging Techniques in Assessing the Surgical Risk for Eloquent Arteriovenous Malformations
Status: UNKNOWN
Conditions: Intracranial Arteriovenous Malformations
Interventions: PROCEDURE: Microsurgical resection of brain AVMs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Oral GW572016 In Advanced Or Metastatic Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer, Non-Small Cell
Interventions: DRUG: GW572016 (lapatinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Intravenous Brivaracetam (Infusion or Bolus) as Adjunctive Antiepileptic Therapy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Brivaracetam tablets|DRUG: Brivaracetam bolus|DRUG: Brivaracetam infusion|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CORE: A Study of OPC-6535 With Asacol® in Maintaining Ulcerative Colitis (UC) Remission
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: OPC-6535|DRUG: Asacol®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: doxorubicin|DRUG: epirubicin|DRUG: pirarubicin|DRUG: cyclophosphamide|DRUG: albumin-bound paclitaxel|DRUG: paclitaxel|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the SeQuent®Please in the Treatment of De-novo Stenoses Versus Taxus™Liberté™
Status: TERMINATED
Conditions: Coronary De-novo Stenoses
Interventions: DEVICE: SeQuent®Please (Paclitaxel coated balloon)|DEVICE: Taxus™Liberté™ (Paclitaxel eluting stent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of RINCE to Reduce Fibromyalgia Effects - 301
Status: TERMINATED
Conditions: Fibromyalgia
Interventions: DEVICE: RINCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A RCT Comparing Spontaneous Natural Cycles and Human Chorionic Gonadotrophin-induced Natural Cycles in FET
Status: COMPLETED
Conditions: Subfertility|Pregnancy
Interventions: PROCEDURE: Daily monitoring of LH and E2|PROCEDURE: hCG induced natural cycle|DEVICE: ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DRUG: Alphagan|DRUG: Phenylephrine|DRUG: Tropicamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Abemaciclib in Treating Patients With Surgically Resectable, Chemotherapy Resistant, Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Breast Ductal Carcinoma In Situ|Breast Fibrocystic Change|Breast Lobular Carcinoma In Situ|Invasive Breast Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Triple-Negative Breast Carcinoma
Interventions: DRUG: Abemaciclib|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Imatinib for Relapsed/Refractory c-Kit Positive Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: AML
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Whole-Body Cryotherapy (WBC) as an Adjunct Treatment on Pain in Fibromyalgia Persons: Short Time Effect.
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Whole-Body Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE