pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Cholinergic Augmentation on Measures of Balance and Gait
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Force and Pressure Distribution Using Macintosh and GlideScope Laryngoscopes in Normal Airway: an in Vivo Study
Status: COMPLETED
Conditions: Tracheal Intubation|Laryngoscopy
Interventions: PROCEDURE: Forces applied by laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Urinary Bladder Neoplasms|Muscle-Invasive Bladder Cancer
Interventions: BIOLOGICAL: Nivolumab|DRUG: Gemcitabine|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis
Status: COMPLETED
Conditions: Candida Vulvovaginitis
Interventions: DRUG: Ibrexafungerp|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 1)
Status: ENROLLING_BY_INVITATION
Conditions: Oxygen Toxicity
Interventions: DIETARY_SUPPLEMENT: Ketogenic food products
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Inhaled Fentanyl on Dyspnea and Exercise Tolerance in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: fentanyl|DRUG: normal saline (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HYPORT: A Phase I/II Study of Hypofractionated Post-operative Radiation Therapy for Head and Neck Cancer
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: RADIATION: Intensity-modulated Radiation Therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
Status: COMPLETED
Conditions: Perinatal Depression|Post Partum Depression|Depression, Postpartum|Depression
Interventions: DRUG: Leuprolide Acetate 3.75 MG/ML|DRUG: Estradiol 2 Mg tablet|DRUG: Micronized progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: IONIS-AGT-LRx|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib (LEN) in Combination With Pembrolizumab (KEYtruda) in Subjects With Locally Advanced or Metastatic Non-clear Cell Renal Cell Carcinoma (The LENKYN Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Lenvatinib|DRUG: Pembrolizumab|PROCEDURE: Research blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tx360® Transnasal Sphenopalatine Ganglion Block in the Treatment of Chronic Migraine
Status: COMPLETED
Conditions: Headache, Migraine
Interventions: DEVICE: Tx360
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Phytosterols Enriched Products Consumption on Carotid Artery Artherosclerotic Plaque
Status: WITHDRAWN
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: plant sterol enriched margarine|DIETARY_SUPPLEMENT: placebo margarine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Enhanced Safety Surveillance of GlaxoSmithKline's (GSK's) Quadrivalent Seasonal Influenza Vaccines During the 2018/19 Influenza Season
Status: COMPLETED
Conditions: Influenza, Human
Interventions: OTHER: Passive enhanced safety surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab After Lung SBRT for Medically Inoperable Early Stage Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Pembrolizumab|RADIATION: Stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis
Status: UNKNOWN
Conditions: Irreversible Pulpitis
Interventions: DRUG: Diclofenac potassium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Determinants of Corticosteroid Insensitivity in Smokers With Asthma
Status: COMPLETED
Conditions: Asthma|Smoking|Steroid Resistance|Corticosteroid Insensitivity
Interventions: DRUG: oral steroid-dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004)
Status: COMPLETED
Conditions: Cervical Cancer|Vulvar Cancer|Vaginal Cancer|Genital Warts|Human Papillomavirus Infection
Interventions: BIOLOGICAL: V503
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: DATAS: The Dual Chamber & Atrial Tachyarrhythmias Adverse Events Study
Status: COMPLETED
Conditions: Ventricular Tachycardia|Ventricular Fibrillation|Defibrillators, Implantable
Interventions: DEVICE: Single Chamber Implantable Cardioverter Defibrillator|DEVICE: Dual Chamber implantable cardioverter defibrilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Esketamine Sedation and Fentanyl Sedation in Pediatric Dental Patients
Status: COMPLETED
Conditions: Ketamine|Fentanyl|Sedation Complication
Interventions: DRUG: Fentanyl|DRUG: Esketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mi QUIT CARE (Mile Square QUIT Community-Access-Referral-Expansion)
Status: RECRUITING
Conditions: Tobacco Use Cessation
Interventions: BEHAVIORAL: Mi Quit Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics
Status: RECRUITING
Conditions: Acute Myeloid Leukaemia (AML)|Myelodysplastic Syndrome (MDS)|Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Interventions: DRUG: Treosulfan|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: What Are the Benefits and Harms of Risk Stratified Screening in the NHS Breast Screening Programme: Study Protocol
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: BC-Predict|OTHER: NHS Breast Screening Programme
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Bioavailability and Metabolism of Diet Phenolic Compounds
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Administration of olive oil|OTHER: Administration of red wine|OTHER: Combination of red wine and olive oil|OTHER: Water|OTHER: Dark beer|OTHER: Light Beer|OTHER: Alcohol free Beer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of EEG Neurofeedback in Pediatric Occupational Therapy to Improve Executive Functioning
Status: UNKNOWN
Conditions: Executive Functioning|Pediatric ALL
Interventions: DEVICE: Zengar Electroencephalogram (EEG) Neurofeedback device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Thread Embedding Acupuncture Analgesia at the EX-B2 Point Combined With Standard Therapy After Laparoscopic Living Donor Nephrectomy
Status: COMPLETED
Conditions: Post Operative Pain, Acute|Renal Transplant Donor of Left Kidney|Quality of Life|Acupuncture Analgesia
Interventions: OTHER: Thread embedding acupuncture and standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Two Versus Three Pneumococcal Conjugate Vaccinations
Status: COMPLETED
Conditions: Streptococcus Pneumoniae Infection
Interventions: BIOLOGICAL: PCV7|BIOLOGICAL: PCV7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Reflective Blanket on Undesirable Perioperative Hypothermia
Status: RECRUITING
Conditions: Abdominal Surgery|General Anesthesia|General Surgery
Interventions: OTHER: the heating procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Hybrid Closed-Loop Control With Smart Prandial Insulin Dosing in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Standard HCL System|DEVICE: HCL System with Smart Bolus Calculator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Versus Laparoscopic Distal Gastrectomy With D2 Lymphadenectomy for Locally Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Robotic distal gastrectomy with D2 nodal dissection|PROCEDURE: Laparoscopic distal gastrectomy with D2 nodal dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness and Safety of Prolonged-release Methylphenidate Hydrochloride in Adult Patients With Attention Deficit/Hyperactivity Disorder.
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: methylphenidate hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of ALZ-801 in APOE4/4 Early AD Subjects
Status: COMPLETED
Conditions: Early Alzheimer's Disease
Interventions: DRUG: Experimental: ALZ-801|DRUG: Placebo Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Trial of Combining Pembrolizumab and Lenvatinib With SBRT for HCC Patients With Portal Vein Thrombosis.
Status: NOT_YET_RECRUITING
Conditions: Unresectable Hepatocellular Carcinoma|Pembrolizumab|Lenvatinib|Stereotactic Body Radiotherapy
Interventions: DRUG: Lenvatinib/Pembrolizumab plus SBRT combinations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of a Single Dose of H1ssF-3928 mRNA-LNP in Healthy Adults
Status: RECRUITING
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Quadrivalent Inactivated Vaccine|OTHER: Sodium Chloride, 0.9%|BIOLOGICAL: VRC-FLUNPF099-00-VP (H1ssF_3928)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Talazoparib in Combination With Belinostat for Metastatic Breast Cancer, Metastatic Castration Resistant Prostate Cancer, and Metastatic Ovarian Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Metastatic Castration-resistant Prostate Cancer|Metastatic Ovarian Carcinoma
Interventions: DRUG: Talazoparib|DRUG: Belinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Uptake and Adherence to HIV Prevention Services With Pre-exposure Prophylaxis (PrEP), HIV Self- Testing and Adherence Support for Very High Risk HIV-negative Young Women Aged 15-24 in Kampala, Uganda
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: POPPi behavioral intervention|BEHAVIORAL: POPPi behavioral intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP
Status: COMPLETED
Conditions: Hyperphosphatemia|End Stage Renal Disease
Interventions: DRUG: Tenapanor|DRUG: Sevelamer Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Single and Multiple Ascending Doses of TC-5214 in Japanese Healthy Elderly Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: TC-5214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate Bone Marrow Cells in the Treatment of Chronic Wounds
Status: TERMINATED
Conditions: Ulcer
Interventions: BIOLOGICAL: Bone Marrow Aspirate|BIOLOGICAL: Cultured Bone Marrow Cells|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a mHealth Platform for Remote Patient Monitoring of CKD and Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: DEVICE: mHealth Remote Monitoring platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer
Status: COMPLETED
Conditions: Radiotherapy Induced Mucositis|Head and Neck Cancer
Interventions: DIETARY_SUPPLEMENT: manuka honey|DIETARY_SUPPLEMENT: placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Prospective Randomized Postmarket Clinical Study of the TRANSITION Stabilization System
Status: TERMINATED
Conditions: Acute Instabilities Thoracic, Lumbar and Sacral Spine|Chronic Instabilities Thoracic, Lumbar and Sacral Spine|Deformities of the Thoracic, Lumbar and Sacral Spine
Interventions: DEVICE: TRANSITION|DEVICE: REVERE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics of Baxdrostat When Given Alone and in Combination With Itraconazole in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Baxdrostat|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Double-Blind, Placebo-Controlled Trial To Evaluate Intravenous Gamma Globulin in Children With Symptomatic HIV Infection Receiving Zidovudine
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Globulin, Immune|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Cobas® Liat CT/NG/MG Test Versus Current Standard Practice for Managing Participants at Increased Risk of Sexually Transmitted Infections
Status: RECRUITING
Conditions: Chlamydia Trachomatis Infection|Neisseria Gonorrhoeae Infection|Mycoplasma Genitalium Infection
Interventions: DIAGNOSTIC_TEST: cobas® liat CT/NG/MG nucleic acid test|OTHER: Standard of Care (SOC): Clinician's Standard Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Postmarketing Surveillance Study to Assess Handling and Patient Satisfaction on Berodual® Respimat® Solution for Inhalation in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Berodual® Respimat® - inhaler
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Daratumumab Intensified Treatment to Eligible MM New Patients CTD-Dara Induction, Follow by Dara Consolidation
Status: UNKNOWN
Conditions: Multiple Myeloma Stage I
Interventions: COMBINATION_PRODUCT: Cyclo Thal Dex Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chatbot-based Intervention to Promote Vaccine Acceptance in Varansi, India
Status: COMPLETED
Conditions: Vaccine Hesitancy
Interventions: BEHAVIORAL: Happy Baby Programme -Vaccine Campaign|BEHAVIORAL: Happy Baby Programme- Vaccine ++ Campaign
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients
Status: COMPLETED
Conditions: Stroke|Spasticity, Muscle|Muscle Fatigue|Gait, Hemiplegic
Interventions: PROCEDURE: Muscle fatigue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Modified Anterior Lamellar Recession for All Grades of Upper Eyelid Trachomatous Cicatricial Entropion
Status: COMPLETED
Conditions: Entropion
Interventions: PROCEDURE: Modified anterior Lamellar Recession
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135), Daratumumab, Lenalidomide or Elranatamab and Lenalidomide Compared With Daratumumab, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Elranatamab|DRUG: Daratumumab|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Out Patient Surgery for Total Knee and Hip Replacement and Unicompartmental Knee Replacement - a Feasibility Study
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Does fulfil of discharge criteria on the day of the surgery|OTHER: Does not fulfil of discharge criteria on the day of the surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: quetiapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immune Response to Different Combinations of the DNA-HIV-PT123 and AIDSVAX® B/E Vaccines in Healthy, HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: AIDSVAX B/E Vaccine|BIOLOGICAL: DNA-HIV-PT123 Vaccine|BIOLOGICAL: Placebo for DNA-HIV-PT123|BIOLOGICAL: Placebo for AIDSVAX B/E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact Study of Minnesota SNAP-Ed Health and Nutrition Education Programs
Status: COMPLETED
Conditions: Obesity|Child
Interventions: BEHAVIORAL: Go Wild with Fruits and Veggies!|BEHAVIORAL: Go Wild with Fruits and Veggies! delayed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Trial of Everolimus, Pomalidomide and Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma in Relapse
Interventions: DRUG: Combination therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Segmental Versus Circumferential Antral Ablation in Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: Circumferential Antral Ablation|PROCEDURE: Segmental Antral ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Colon Mucinous Adenocarcinoma|Colon Signet Ring Cell Adenocarcinoma|Rectal Mucinous Adenocarcinoma|Rectal Signet Ring Cell Adenocarcinoma|Recurrent Colon Carcinoma|Recurrent Rectal Carcinoma|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer
Interventions: DRUG: Akt Inhibitor MK2206|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits
Status: COMPLETED
Conditions: Respiratory Distress Syndrome|Lower Respiratory Tract Infection
Interventions: DEVICE: Low-Resource Oxygen Blender
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
Status: RECRUITING
Conditions: Pancreatic Disease|Pancreatic Cancer|Pancreatic Cyst|Gastrointestinal Tumor|Bile Duct Diseases|Bile Duct Cancer|Lymph Node Disease|Submucosal Tumor of Gastrointestinal Tract|Gastrointestinal Cancer
Interventions: DEVICE: Endoscopic ultrasound examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Fruit And Vegetables and OUtcomes After Removal of Impacted TEeth
Status: COMPLETED
Conditions: Postoperative Morbidity|Trauma|Wound Healing
Interventions: DIETARY_SUPPLEMENT: Juice plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Breast Cancer|Colorectal Cancer|Head and Neck Cancer|Lung Cancer|Lymphoma|Prostate Cancer|Testicular Germ Cell Tumor|Tobacco Use Disorder|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: nicotine|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Vitamin D Replacement in Patients With Primary Hyperparathyroidism (PHPT)
Status: COMPLETED
Conditions: Hyperparathyroidism
Interventions: DRUG: Vitamin D|DEVICE: Four-dimensional computed tomography (4DCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Naturalistic Study, Comparison of Divalproex Extended Release (ER) and Quetiapine for Adults With Acute Mania or Mixed Episodes
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: divalproex ER|DRUG: quetiapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
Status: ENROLLING_BY_INVITATION
Conditions: Preterm Birth|Pediatric Cancer|Hirschsprung Disease|Congenital Malformation|Congenital Heart Disease|Nutrition Disorder, Child
Interventions: DEVICE: e-health device with application
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PsA Treatment With hOKT3γ1 (Ala-Ala)
Status: TERMINATED
Conditions: Arthritis, Psoriatic
Interventions: DRUG: hOKT3gamma1(Ala-Ala)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel and Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Cervical Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer
Interventions: DRUG: docetaxel|RADIATION: cesium Cs 137|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study of Tarceva (Erlotinib) in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer With Wild-Type Epidermal Growth Factor Receptor (EGFR) Gene (WILT)
Status: COMPLETED
Conditions: Non-Squamous Non-Small Cell Lung Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RAD001 in Combination With Capecitabine and Oxaliplatin (XELOX) in Patients With Advanced Gastric Cancer: RAD001+XELOX
Status: COMPLETED
Conditions: Advanced Gastric Cancer
Interventions: DRUG: RAD001, Capecitabine, Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period
Status: COMPLETED
Conditions: Faecal Incontinence
Interventions: DRUG: 1R, 2S-methoxamine hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Activity-based Training for Preventing Falls for Older Adults With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Fall Prevention|Virtual Reality|Exercise Training
Interventions: OTHER: VR activity-based|OTHER: Exercise-based (Baduanjin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Osimertinib and Stereotactic Ablative Radiation (SABR) in EGFR Mutant NSCLC
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: Osimertinib|RADIATION: SABR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGA for TEE: Safe Alternative to Deep Sedation for Patients With High-risk Cardiopulmonary Disease.
Status: WITHDRAWN
Conditions: Cardiopulmonary Disease
Interventions: PROCEDURE: TEE with SGA|PROCEDURE: TEE with Deep Sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Electroconvulsive Therapy (ECT) for Agitation in Dementia (AD)
Status: RECRUITING
Conditions: Alzheimer Dementia|Agitation,Psychomotor
Interventions: DEVICE: Electroconvulsive Therapy (ECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Intermittent Exogenous Ketosis in the Physiological and Muscular Adaptive Response to Endurance Training
Status: ACTIVE_NOT_RECRUITING
Conditions: Exercise Adaptations
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Ketone ester
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Engaging General Practice in the Prevention of Patients With Alcohol Problems
Status: COMPLETED
Conditions: Alcohol Drinking
Interventions: BEHAVIORAL: Feedback about patients at risk|BEHAVIORAL: Dissemination guideline and patient information letters|BEHAVIORAL: Tailored educational training|BEHAVIORAL: Tailored outreach based facilitator support|BEHAVIORAL: Facilitation of co-operation with local addiction services|BEHAVIORAL: Patient directed interventions|BEHAVIORAL: Reminder-card for GP's desk|BEHAVIORAL: Personal feedback to patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose:
Clinical trial: Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Schizophrenia
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Trabectedin Versus Doxorubicin-Based Chemotherapy in Participants With Translocation-Related Sarcomas (TRS)
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: Trabectedin|DRUG: Doxorubicin|DRUG: Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Vinorelbine and Cisplatin as Induction Therapy With Radiotherapy in Patients With Unresectable NSCLC
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Vinorelbine|DRUG: Cisplatin|DRUG: Vinorelbine|DRUG: Cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sleep Hygiene Education on Sleep Health in Community-Dwelling Older Adults
Status: COMPLETED
Conditions: Sleep Habit, Good|Sleep Hygiene|Health Behavior
Interventions: BEHAVIORAL: One-time educational video|BEHAVIORAL: One-time educational video plus automated text messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence
Status: RECRUITING
Conditions: Somnolence Disorder, Excessive
Interventions: OTHER: scale of severity|GENETIC: blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PEG-IFN Alfa-2b Plus Ribavirin for Treatment of Mexican naïve Patients With Chronic Hepatitis C Infected With Genotype 1 (Study P04511)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: Peginterferon alfa-2b (SCH 054031)|DRUG: Ribavirin (SCH 018908)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Cetuximab + Chemotherapy Combined With Short-course Radiotherapy
Status: RECRUITING
Conditions: Neoadjuvant Treatment|Rectal Cancer|Cetuximab|Radiotherapy
Interventions: DRUG: cetuximab+mFOLFOX6|RADIATION: short-course radiotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Virtual Reality System for Pain and Anxiety Management During Outpatient Hysteroscopy
Status: COMPLETED
Conditions: Infertility|Vaginal Blood Loss
Interventions: DEVICE: SootheVR: AppliedVR, Los Angeles, California
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duroplasty for Injured Cervical Spinal Cord With Uncontrolled Swelling
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: PROCEDURE: Duroplasty|PROCEDURE: Spinal surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Telerehabilitation Program in Subacromial Syndrome (Telerehab Sis)
Status: UNKNOWN
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: Telerehabilitation|OTHER: Traditional Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block Versus Caudal Block for Perioperative Analgesia in Pediatric Cancer Patients
Status: RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: Erector spinae plane block|PROCEDURE: Caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Antiviral Therapy on Bone Mineral Density and Metabolism in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Liver Diseases|Virus Diseases
Interventions: DRUG: peginterferon alfa-2a and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: TACE Combined With Lenvatinib Versus TACE Sequential Lenvatinib in the Treatment of Intermediate/Advanced Liver Cancer
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TACE(Transcatheter arterial chemoembolization)|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Safety and Efficacy of ABT-925 in Subjects With Acute Exacerbation of Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: ABT-925|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: i-BiSSkApp for Swallowing Rehabilitation in Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: i-BiSSkApp (tablet application) with swallowing therapy|BEHAVIORAL: Traditional behavioral swallowing therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Diathermy Cone Biopsy for the Treatment of Cervical Intraepithelial Lesion
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: Straight Wire Excision of Transformation Zone|PROCEDURE: Large Loop Excision of Transformation Zone (cone biopsy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Impairment Following Sedation for Colonoscopy With Propofol, Midazolam and Fentanyl Combinations
Status: COMPLETED
Conditions: Cognitive Impairment
Interventions: DRUG: Propofol, midazolam, fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of the Double-Trunk Mask on Oxygenation Titration in COVID-19
Status: COMPLETED
Conditions: COVID|Hypoxemia
Interventions: OTHER: Standard interface|DEVICE: Double-Trunk Mask
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Allogeneic Blood-derived Natural Killer Cells to Evaluate Safety and Tolerability in Cancer Refractory to Conventional Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Pathologically Confirmed Cancer Refractory to Conventional Therapy|Refractory Cancer|Metastatic Cancer|Recurrent Cancer|Solid Tumor, Adult|Solid Tumor|Advanced Cancer|Advanced Solid Tumor
Interventions: BIOLOGICAL: SNK02
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Genetic Polymorphism on Drug-Drug Interactions Involving CYP2D6
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dextromethorphan 5 MG|DRUG: Tramadol 10 mg|DRUG: Duloxetine 60mg|DRUG: Paroxetine 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Influence of Dosages of 1-84 and 7-84 Fragments of Parathyroid Hormone Compared to Conventional Dosage on the Balance of Calcium and Phosphate in Hemodialysis (PTH)
Status: COMPLETED
Conditions: Hemodialysis Patients
Interventions: OTHER: Determination of PTH following|OTHER: Determination of PTH following:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Mental Effects of Analgesic Drugs: Paracetamol and Ibuprofen
Status: UNKNOWN
Conditions: Empathy
Interventions: DRUG: Paracetamol|DRUG: Ibuprofen|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of S-adenosyl-L-methionine in Treatment of Chronic Hepatitis B Patients With Cholestasis
Status: UNKNOWN
Conditions: Hepatitis B|Cholestasis
Interventions: DRUG: Ademetionine 2|DRUG: Ademetionine 1|DRUG: Ademetionine 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Action to Control Cardiovascular Risk in Diabetes (ACCORD)
Status: COMPLETED
Conditions: Atherosclerosis|Cardiovascular Diseases|Hypercholesterolemia|Hypertension|Diabetes Mellitus, Type 2|Diabetes Mellitus|Coronary Disease
Interventions: DRUG: Anti-hyperglycemic Agents|DRUG: Anti-hypertensive Agents|DRUG: Blinded fenofibrate or placebo plus simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DRUG: THR-184|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regulation of Coagulation in Orthopedic Surgery to Prevent DVT and PE, a Controlled, Double-blind, Randomized Study of BAY 59-7939 in the Extended Prevention of VTE in Patients Undergoing Elective Total Hip Replacement
Status: COMPLETED
Conditions: Prevention|Venous Thromboembolism
Interventions: DRUG: Rivaroxaban (BAY59-7939)|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for People With Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary Syndrome
Status: COMPLETED
Conditions: Adult T-Cell Lymphoma/Leukemia|Sezary Syndrome|Mycosis Fungoides
Interventions: DRUG: Recombinant human Interleukin-15 (rhIL-15)|BIOLOGICAL: Mogamulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab, Idarubicin, and Cytarabine in Treating Patients With Blast Phase Chronic Myelogenous Leukemia
Status: TERMINATED
Conditions: Blastic Phase Chronic Myelogenous Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Interventions: BIOLOGICAL: bevacizumab|DRUG: idarubicin|DRUG: cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Motivational Intervention to Improve Medication Adherence for Adolescents With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Medication Adherence
Interventions: BEHAVIORAL: Brief Motivational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Oral Contraceptive Pills and Calcium Supplements in Treatment of Premenstrual Syndrome
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: DRUG: Yasmin|DIETARY_SUPPLEMENT: Calver|DRUG: Placebo 1|DRUG: Placebo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity in Age De-Escalation of PfSPZ Vaccine in Tanzanian Adults, Children, and Infants
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: PfSPZ Vaccine|OTHER: Normal Saline|BIOLOGICAL: PfSPZ Challenge (for CHMI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial to Evaluate the Pharmacokinetics and Safety Profile of BAY94-9027 Following Single and Multiple Dose Administration
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: BAY94-9027 + Recombinant Factor VIII (Kogenate FS, BAY14-2222)|BIOLOGICAL: BAY94-9027 + Recombinant Factor VIII (Kogenate FS, BAY14-2222))
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability Study of Cotadutide in Japanese Obese Subjects With Type 2 Diabetes Melitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Placebo|DRUG: Cotadutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IIa Trial to Test Safety and Efficacy Interferon Gamma Treatment in Elevating Frataxin Levels in FRDA Patients
Status: COMPLETED
Conditions: Friedreich Ataxia
Interventions: DRUG: gamma interferon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Motexafin Gadolinium With Whole Brain Radiation Therapy Followed by Stereotactic Radiosurgery Boost in the Treatment of Patients With Brain Metastases
Status: TERMINATED
Conditions: Neoplasm Metastasis|Brain Neoplasms
Interventions: DRUG: Motexafin gadolinium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of GSK1278863 in Japanese Hemodialysis Subjects With Anemia Associated With Chronic Kidney Disease Who Are Not Taking Erythropoiesis Stimulating Agents
Status: COMPLETED
Conditions: Anaemia
Interventions: DRUG: GSK1278863|DRUG: Iron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of THN102 in Patients With Parkinson's Disease and Excessive Daytime Sleepiness
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: THN102 Dosage A|DRUG: THN102 Dosage B|DRUG: THN102 Dosage C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of DWJ1392 and DWC20164 in Healthy Male Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: DWJ1392|DRUG: DWC20164
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Baduanjin-eight-silken-movement With Self-efficacy Building for Patients With Chronic Heart Failure (BESMILE-HF Study)
Status: UNKNOWN
Conditions: Heart Failure NYHA Class II|Heart Failure NYHA Class III
Interventions: BEHAVIORAL: BESMILE-HF program|DRUG: Usual medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT