pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Immunogenicity and Safety Study of a Vaccine Against Lyme Borreliosis, in Healthy Adults Aged 18 to 65 Years. Randomized, Controlled, Observer-blind Phase 2 Study.
Status: COMPLETED
Conditions: Lyme Borreliosis
Interventions: BIOLOGICAL: VLA15|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: N-acetylcysteine (NAC)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of DMXAA (ASA404) in Combination With Chemotherapy in Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: DMXAA in combination with carboplatin and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Operative Assessment of Chest Wall Invasion in NSCLC Using Pre-Operative, Surgeon Performed Ultrasound
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: PROCEDURE: Transthoracic Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of the Effect of Short-term Structured Psychological Care in Patients
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: Routine Care|PROCEDURE: Short-term structured psychological Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Effect of Nitrous Oxide-Oxygen Conscious Sedation and Cognitive-behavioral Therapy on Children's Anxiety in Dentistry
Status: COMPLETED
Conditions: Clinical Anxiety|Clinical Cooperation
Interventions: DRUG: Nitrous Oxide-Oxygen conscious sedation|BEHAVIORAL: cognitive-behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: The Effect of Pregabalin on Pain of Propofol Injection
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Lidocaine|DRUG: Pregabalin|DRUG: propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum
Status: COMPLETED
Conditions: Pyoderma Gangrenosum
Interventions: DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of SARS-CoV-2 Protein Subunit Recombinant Vaccine
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: SARS-CoV-2 Protein Subunit Recombinant Vaccine|BIOLOGICAL: SARS-CoV-2 Inactivated Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Method of Non-Invasive Brain Stimulation (kTMP) to Enhance Motor Function in Chronic Stroke Patients
Status: ENROLLING_BY_INVITATION
Conditions: Stroke
Interventions: DEVICE: kTMP|DEVICE: Sham kTMP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: DRUG: Tramadol Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial Assessing Once Daily Administration of Mometasone Furoate DPI in Asthmatics (Study P02177)
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Mometasone furoate|DEVICE: Mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nerve Blocks With Dexamethasone and Local Anaesthetic to Improve Postoperative Analgesia
Status: UNKNOWN
Conditions: Nerve Block
Interventions: DRUG: Local Anesthetic ropivacaíne|DRUG: Perineural Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: This Study Assess Some Physiological Parameters, Blood Picture, and Hemodynamic Parameters, Blood Pressure, Respiratory Assess by SPO2, During Different Periods in Laparoscopic Surgery
Status: NOT_YET_RECRUITING
Conditions: Anesthesia Complication|Physiological Parameter
Interventions: PROCEDURE: general anesthesia drug (like Propofol, esmeron, and ketamin, .effects of pneumoperitoneum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aprepitant Effects in Intravenous Heroin Dependence
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: Aprepitant|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin Plus Romidepsin & Nivolumab in Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple-Negative Breast Cancer|Breast Cancer
Interventions: DRUG: Romidepsin|DRUG: Cisplatin|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Local Infiltration Analgesia and Pecs Block for Analgesia in Mastectomy With Axillary Dissection - an Equivalence Study
Status: UNKNOWN
Conditions: Mastectomy; Lymphedema|Local Infiltration|Anesthesia, Local|Block
Interventions: PROCEDURE: PECs Block|PROCEDURE: Local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: "Juego de LLaves": Study Protocol of a Universal School-based Drug Use Prevention Program (PSIDUP)
Status: NOT_YET_RECRUITING
Conditions: Behavior, Addictive|Adolescent - Emotional Problem|Alcohol Abuse|Smoking Behaviors|Adolescent Behavior|Psychological
Interventions: BEHAVIORAL: Juego de Llaves
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: APX005M With Concurrent Chemoradiation for Resectable Esophageal and Gastroesophageal Junction Cancers
Status: COMPLETED
Conditions: Esophageal Cancer|GastroEsophageal Cancer
Interventions: DRUG: APX005M|RADIATION: Radiation Therapy|DRUG: Paclitaxel|DRUG: Carboplatin|PROCEDURE: Surgical resection of tumor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antithyroid Drug Treatment of Thyrotoxicosis in Young People
Status: COMPLETED
Conditions: Paediatric Thyrotoxicosis
Interventions: PROCEDURE: Block and Replace|PROCEDURE: Dose Titration|DRUG: carbimazole|DRUG: propylthiouracil|DRUG: thyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Atezolizumab With MVA-BN-Brachyury and PROSTVAC For Intermediate-Risk And High-Risk Localized Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Adenocarcinoma
Interventions: COMBINATION_PRODUCT: MVA-BN-Brachyury
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Redirected MazF-CD4 Autologous T Cells for HIV Gene Therapy
Status: COMPLETED
Conditions: HIV
Interventions: GENETIC: Autologous CD4+ T cells genetically modified with a retroviral vector expressing the MazF endoribonuclease gene (MazF-T), given via intravenous infusion.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Distribution of Cell-cell Junction Proteins in Arrhythmic Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Arrhythmogenic Right Ventricular Dysplasia|Brugada Syndrome|Cardiac Channelopathy
Interventions: DIAGNOSTIC_TEST: obtaining a buccal smear sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Cancer|Cancer of Head and Neck|Cancer, Advanced|Cancer, Metastatic|Tumor|Tumor Recurrence|Tumor Neck|Tumor Metastasis|Oral Cancer|Oropharyngeal Cancer|Oropharynx Cancer|Oropharynx Cancer, Stage III|Oropharynx Cancer, Recurrent|Oropharynx Cancer, Metastatic
Interventions: DRUG: Pembrolizumab|RADIATION: Radiation therapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatments for Postamputation Pain
Status: RECRUITING
Conditions: Residual Limb Pain|Amputation Neuroma|Phantom Limb Pain|Pain, Neuropathic|Pain, Nerve
Interventions: PROCEDURE: Targeted Muscle Reinnervation (TMR)|PROCEDURE: Regenerative Peripheral Nerve Interface (RPNI)|PROCEDURE: Standard neuroma treatment, neuroma excision, and muscle burying
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Tolerability, Reactogenicity, Safety and Immunogenicity of Flu-M [Inactivated Split Influenza Vaccine] in Pregnant Women
Status: COMPLETED
Conditions: Influenza, Human|Vaccination; Infection|Vaccines
Interventions: BIOLOGICAL: Flu-M, Inactivated split influenza vaccine|BIOLOGICAL: Ultrix®, Inactivated Split Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adult Stem Cell Therapy for Repairing Articular Cartilage in Gonarthrosis
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Knee Injuries|Joint Diseases|Rheumatic Diseases|Cartilage Diseases
Interventions: OTHER: Autologous MSC knee implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ursodeoxycholic Acid Prevents Total Parenteral Nutrition Cholestasis
Status: UNKNOWN
Conditions: Cholestasis of Parenteral Nutrition
Interventions: DRUG: Ursodeoxycholic Acid 250 Mg Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Treatment of Refractory Bladder Pain Syndrome With DMSO and DMSO With Botulinum Toxin A
Status: COMPLETED
Conditions: Bladder Pain Syndrome
Interventions: DRUG: DMSO|DRUG: Botox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open Label Study of Long Term Safety Evaluation of Alirocumab
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Lipid-Modifying Therapy (LMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin + PDT
Status: RECRUITING
Conditions: Port-wine Birthmark|Port-Wine Stain|Nevus Flammeus
Interventions: DRUG: Hemopfin+PDT|DEVICE: Vehicle+PDT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage II Breast Cancer|Stage IIIA Breast Cancer
Interventions: PROCEDURE: Axillary Lymph Node Dissection (ALND)|RADIATION: Nodal Radiation Therapy|RADIATION: Axillary Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Intake and Epigenetic Alteration in the Spermatozoa of Singletons and Twins
Status: COMPLETED
Conditions: Fertility Issues|Nutrition, Healthy|Epigenetic Disorder|Overnutrition
Interventions: DIETARY_SUPPLEMENT: Isocaloric Unprocessed Diet|DIETARY_SUPPLEMENT: Isocaloric Processed Diet|DIETARY_SUPPLEMENT: Excess Calorie Unprocessed Diet|DIETARY_SUPPLEMENT: Excess Calorie Processed Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Therapeutic Virtual Reality : Impact on the Management of Pain and Anxiety Related to Hematology Care (REVEH)
Status: COMPLETED
Conditions: Hematologic Neoplasms
Interventions: DEVICE: Virtual Reality|DRUG: Kalinox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: 3-week Study to Evaluate Efficacy and Safety of Ziprasidone With Either Lithium or Divalproex in Acutely Manic Subjects
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Placebo|DRUG: Ziprasidone|DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Speech Entrainment Treatment for People With Aphasia
Status: RECRUITING
Conditions: Aphasia, Acquired
Interventions: BEHAVIORAL: Audiovisual Speech Entrainment Practice|BEHAVIORAL: Auditory Speech Entrainment Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ABBV-011 Alone and in Combination With Budigalimab (ABBV-181) in Participants With Relapsed or Refractory Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: ABBV-011|DRUG: Budigalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Alcohol-Pain Connection: Mechanisms and Genetic/Psychological Correlates
Status: COMPLETED
Conditions: Pain|Alcohol Drinking|Acute Pain|Drinking Behavior
Interventions: DRUG: Low Alcohol|DRUG: Moderate Alcohol|DRUG: Placebo Alcohol|OTHER: Pain Induction|OTHER: No Pain Induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Patient Portal Flu Vaccine Reminders (5)
Status: COMPLETED
Conditions: Influenza|Respiratory Tract Infections
Interventions: BEHAVIORAL: Text Fixed R/R Messages with Direct Appointment Schedule Link|BEHAVIORAL: Text Pre-Appointment Reminder|BEHAVIORAL: Portal Pre-Commitment Prompt with Tailored R/R Messages with Direct Appointment Schedule Link|BEHAVIORAL: Portal Fixed R/R Messages with Direct Appointment Schedule Link|BEHAVIORAL: Portal Pre-Appointment Reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Low Adherent Dressing Versus the Standard of Care for the Management of Skin Grafts Over Thermal Burns
Status: COMPLETED
Conditions: Burns|Skin Burn Requiring Skin Graft
Interventions: DEVICE: P6 Low Adherent Dressing|OTHER: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: COVID-19: BCG As Therapeutic Vaccine, Transmission Limitation, and Immunoglobulin Enhancement
Status: COMPLETED
Conditions: COVID-19|Therapeutic Vaccine|BCG|SARS-CoV 2|Transmission
Interventions: BIOLOGICAL: BCG|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patency of a Prototype Large Plastic Biliary Stent in the Palliation of Malignant Distal Biliary Strictures.
Status: TERMINATED
Conditions: Stricture|Obstruction|Cancer
Interventions: DEVICE: Large plastic biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPG 7909 Plus Herceptin® In Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Carcinoma, Breast
Interventions: DRUG: 0.04 mg/kg CpG 7909|DRUG: Herceptin®|DRUG: 0.08 mg/kg CpG 7909|DRUG: Herceptin®|DRUG: 0.12 mg/kg CpG 7909|DRUG: Herceptin®|DRUG: 0.16 mg/kg CpG 7909|DRUG: Herceptin®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Different Graft Harvesting Techniques Applied in Localized Gingival Recessions
Status: COMPLETED
Conditions: Gingival Recession, Localized|Sensitivity, Tooth|Attachment Loss, Periodontal
Interventions: PROCEDURE: Coronally advanced flap with connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of CTG and T-PRF on Peri-Implant Soft Tissue
Status: COMPLETED
Conditions: Peri-implant Mucositis|Peri-Implantitis|Thin Gingiva
Interventions: PROCEDURE: Placement of Implants and Thickening Peri-Implant Mucosa with T-PRF|PROCEDURE: Placement of Implants and Thickening Peri-Implant Mucosa with CTG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Study on Combizym and Bifidobacteri to Prevent the Recurrence of Colon Polyps
Status: UNKNOWN
Conditions: Combizym|Bifidobacteri|Colon Polyps
Interventions: DRUG: Combizym|DRUG: Bifidobacteri|DRUG: Combizym + Bifidobacteri
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing the Effect of Fulguration Versus Fulguration and Hydrodistension in Interstitial Cystitis/Bladder Pain Syndrome
Status: COMPLETED
Conditions: Interstitial Cystitis|Bladder Pain Syndrome
Interventions: PROCEDURE: Transurethral fulguration of the Hunner lesion|PROCEDURE: Combination treatment of bladder hydrodistension and transurethral fulguration of the Hunner lesion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pathways to Care-Understanding the Impact of an Indigenous Elder Co-lead in Perinatal Dialectical Behaviour Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Dialectical Behaviour Therapy
Interventions: BEHAVIORAL: Modified Dialectical Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: evorpacept|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: School-based Treatment for Anxious Children
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of Getting Better Bite by Bite for Eating Disorders
Status: ACTIVE_NOT_RECRUITING
Conditions: Eating Disorders|Bulimia Nervosa|Binge-Eating Disorder
Interventions: OTHER: Culturally Adapted Getting Better Bite By Bite (Ca-GBBB) intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus(T2DM)
Interventions: DRUG: Saxagliptin 5 mg|DRUG: Metformin XR 500 mg|DRUG: Mertformin XR 2 x 500 mg|DRUG: Komboglyze XR 5/500 mg|DRUG: Komboglyze XR 5/1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Single-Center, Epidemiological Study of the Survivorship of the DePuy Sigma HP Unicompartmental Knee Prosthesis
Status: COMPLETED
Conditions: Osteoarthritis|Unicompartmental Knee Arthroscopy
Interventions: DEVICE: DePuy Sigma HP Partial Knee
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy
Status: RECRUITING
Conditions: Recurrent Glioblastoma, IDH-Wildtype|Recurrent Astrocytoma, IDH-Mutant, Grade 4|Astrocytoma, Grade IV
Interventions: BIOLOGICAL: Allogeneic Adipose-derived Mesenchymal Stem Cells|PROCEDURE: Biospecimen Collection|PROCEDURE: Craniotomy|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Ommaya Reservoir Tap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Arginine Supplementation in the Metabolic Syndrome
Status: COMPLETED
Conditions: Overweight|Hypertriglyceridemic Waist
Interventions: DIETARY_SUPPLEMENT: One form of arginine|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers
Status: COMPLETED
Conditions: Leg Ulcers
Interventions: DEVICE: Biatain|DEVICE: Biatain Ibu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy
Status: COMPLETED
Conditions: Seizures|Convulsions|Epilepsy|Osteopenia|Osteoporosis
Interventions: DRUG: Topiramate|DRUG: Carbamazepine|DRUG: Valproic acid|DRUG: Normal control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Adults With Acute Bronchitis in the Primary Healthcare Setting
Status: COMPLETED
Conditions: Acute Bronchitis
Interventions: DIETARY_SUPPLEMENT: Atusin CAP|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Blood Pressure on rSO2 in Carotid Endarterectomy (CEA)
Status: UNKNOWN
Conditions: Intra-operative Hypotension|Carotid Stenosis
Interventions: DRUG: Administration of phenylephrine|DRUG: Administration of ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment
Status: COMPLETED
Conditions: Myocardial Infarction [C14.907.585.500]
Interventions: DRUG: Low-dose Rosuvastatin|DRUG: High-dose Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mi Propio Camino Intervention RCT for Blood Pressure Medication Adherence
Status: RECRUITING
Conditions: Hypertension|Medication Adherence
Interventions: BEHAVIORAL: Mi Propio Camino (MPC)|BEHAVIORAL: Habilidades para Controlar la Presion (HCP; Skills for Blood Pressure Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominal Wall Closure With Triclosan-coated Suture
Status: COMPLETED
Conditions: Infection
Interventions: PROCEDURE: abdominal wall closure|PROCEDURE: surgical site infection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Evaluate the Lipid-Lowering Efficacy and Safety of Simvastatin 40 Mg Tablet In Patients With Hypercholesterolemia (0733-264)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK0733, simvastatin / Duration of Treatment: 12 Weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation and Chronic Pain
Status: RECRUITING
Conditions: Chronic Pain
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|DEVICE: Transcranial Direct Current Stimulation (tDCS) sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Temporal Trends of Thrombolysis Treatment in Chinese Acute Ischemic Stroke (AIS) Patients From 2007-2017: Analysis of China National Stroke Registry (CNSR) I, II, and III; CTP-Draft Review Performed;
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: IV rtPA (intravenous recombinant plasminogen activator)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect Of Stretching Exercise on Pectoralis Minor Myofascial Latent Trigger Points
Status: COMPLETED
Conditions: Myofascial Trigger Point Pain
Interventions: OTHER: Manual pressure release|OTHER: Contract-relax PNF stretch|OTHER: Z-stretch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma (DLBCL)
Interventions: DRUG: glofitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Surgical Treatment of Recurrent Shoulder Dislocations
Status: RECRUITING
Conditions: Shoulder Instability
Interventions: PROCEDURE: Bankart Repair|PROCEDURE: Anatomic Glenoid Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum
Status: COMPLETED
Conditions: Adenocarcinoma of the Rectum|Stage II Rectal Cancer|Stage III Rectal Cancer
Interventions: DRUG: oxaliplatin|DRUG: fluorouracil|RADIATION: external beam radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-center Comparative Study of Variation in Acetabular Anteversion According to Pelvic Tilt in Patients With Femoro-acetabular Impingement and Healthy Volunteers.
Status: RECRUITING
Conditions: Femoro-acetabular Impingement
Interventions: OTHER: Scanner and EOS imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ChAdOx1 85A Aerosol Versus Intramuscular Vaccination in Healthy Adults (TB039)
Status: COMPLETED
Conditions: Mycobacterium Tuberculosis, Protection Against|Tuberculosis
Interventions: BIOLOGICAL: ChadOx1 85A - aerosol|BIOLOGICAL: ChadOx1 85A - IM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Slowly Digesible Starch on Diabetes Risk Factors
Status: COMPLETED
Conditions: Prediabetes
Interventions: DIETARY_SUPPLEMENT: Amylose|DIETARY_SUPPLEMENT: Amylopectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Oral Immunotherapy for Young Children With Peanut Allergy - Small Children OIT
Status: ACTIVE_NOT_RECRUITING
Conditions: Peanut Allergy
Interventions: DIETARY_SUPPLEMENT: Peanut (bamba)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Docetaxel or Gemcitabine-based Chemotherapy in East Asian and Caucasian Patients
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: gemcitabine and carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women
Status: RECRUITING
Conditions: Infertility, Female|Perimenopausal Disorder|Menstrual Cycle Abnormal
Interventions: BIOLOGICAL: Autologous Platelet Rich Plasma (PRP) intra ovarian infusion|OTHER: Placebo: Autologous Platelet Free Plasma (PFP) intra ovarian infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhanced Pulmonary Rehabilitation With Digital Remote Home Monitoring
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: digital Remote Patient Monitoring+BEPR+ (dRPM+)|BEHAVIORAL: Enhanced Breathe Easy Pulmonary Rehabilitation Program (BEPR+)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unrestricted Diet for Screening Colonoscopy
Status: COMPLETED
Conditions: Bowel Cleansing|Colonoscopy|Bowel Cancer
Interventions: OTHER: Unrestricted diet before colonoscopy|OTHER: 1-day low residue diet|DRUG: Bisacodyl 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study With TEPEZZA in Patients With Diffuse Cutaneous Systemic Sclerosis (dcSSc)
Status: TERMINATED
Conditions: Diffuse Cutaneous Systemic Sclerosis
Interventions: BIOLOGICAL: TEPEZZA|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Activation of miRNA and Proteins After Acute Experimental Pain. (miRNA: Micro RNA)
Status: COMPLETED
Conditions: Hypertonic Saline|Isotonic Saline
Interventions: OTHER: hypertonic saline|OTHER: Saline injection|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Compare the Effects of Z7200 And Symbicort® Turbohaler on Respiratory Imaging Parameters in Asthmatic Patients
Status: COMPLETED
Conditions: Asthma|Asthma Chronic|Asthma Bronchial|Asthmatic
Interventions: DRUG: Z7200|DRUG: Symbicort® Turbohaler®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Apatinib and Irinotecan in Treating Patients With Recurrent High-grade Glioma
Status: UNKNOWN
Conditions: High-grade Glioma
Interventions: DRUG: Apatinib and Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: nMARQ™ Pulmonary Vein Isolation System for the Treatment of Paroxysmal Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DEVICE: nMARQ Navigation Catheters|DEVICE: NaviStar ThermoCool Catheters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: FOLFOX regimen|DRUG: dexamethasone|DRUG: floxuridine|DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Korean Post-marketing Surveillance Ngenla® Pre-filled Pen Injection for the Treatment of Pediatric Patients With Growth Disturbance Due to Insufficient Secretion of Growth Hormone
Status: ACTIVE_NOT_RECRUITING
Conditions: Pediatric Growth Hormone Deficiency
Interventions: DRUG: Ngenla
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intranasal Oxytocin Treatment for Social Deficits in Children With Autism
Status: COMPLETED
Conditions: Autism
Interventions: DRUG: Oxytocin nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aliskiren/Amlodipine/Hydrochlorothiazide (HCTZ) Versus Aliskiren/Amlodipine in US Minority Patients With Stage II Systolic Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren/Amlodipine|DRUG: Aliskiren/Amlodipine and Hydrochlorothiazide (HCTZ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Performance of Xpert MTB/RIF and XDR Assay for Diagnosis of Pulmonary Tuberculosis and Resistant Pulmonary TB
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis, Pulmonary
Interventions: GENETIC: xpert MTB , XDR assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Clinical Stage II Esophageal Adenocarcinoma AJCC v8|Clinical Stage III Esophageal Adenocarcinoma AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IV Esophageal Adenocarcinoma AJCC v8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Locally Advanced Esophageal Adenocarcinoma|Locally Advanced Gastroesophageal Junction Adenocarcinoma|Metastatic Esophageal Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Unresectable Esophageal Adenocarcinoma|Unresectable Gastroesophageal Junction Adenocarcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|DRUG: Fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin|BIOLOGICAL: Pembrolizumab|DRUG: Propranolol Hydrochloride|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.
Status: RECRUITING
Conditions: Inflammation|Knee Pain Chronic
Interventions: DIETARY_SUPPLEMENT: UCII, glucosamine and curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Randomized, Double-Blind, Phase III Trial to Evaluate the Safety and Efficacy of Saxagliptin Co-administered With Dapagliflozin Compared to Saxagliptin or Dapagliflozin All Given as add-on Therapy to Metformin in Subject With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Inadequate Glycaemic Control
Interventions: DRUG: Dapagliflozin|DRUG: Placebo for Dapagliflozin|DRUG: Saxagliptin|DRUG: Placebo for Saxagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab, Ipilimumab, and Bicalutamide in Human Epidermal Growth Factor (HER) 2 Negative Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasm Female|Breast Cancer|Breast Carcinoma|Breast Tumor
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin Use to Improve the Coagulation Profile in Patients With Venous Thrombosis
Status: COMPLETED
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coping Skills Training for Early Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Comprehensive Coping Skills Training|BEHAVIORAL: Arthritis Education Sessions|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Composite Variability Index and Propofol Remifentanil Anesthesia
Status: COMPLETED
Conditions: Measure of Nociception
Interventions: DRUG: rising remifentanil concentrations|DRUG: falling remifentanil concentrations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Use of CereGate Therapy for Freezing of Gait in PD
Status: RECRUITING
Conditions: Parkinson Disease|Freezing of Gait|Deep Brain Stimulation
Interventions: DEVICE: CereGate Software; BSN cDBS Programmer; BSN Burst Programmer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Alendronate 70mg Formulation on Bone Turnover Markers and Patient Reported Outcomes
Status: UNKNOWN
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: Binosto 70Mg Effervescent Tablet|DRUG: Fosamax 70Mg Tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: CC-99677|DRUG: Methotrexate|DRUG: Sulfasalazine|DRUG: Itraconazole|DRUG: Rifampin|DRUG: Midazolam|DRUG: Digoxin|DRUG: Metformin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Optimization for Pulsed-dose-rate (PDR)/High-dose-rate (HDR) Brachytherapy Alone for Early Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: Interstitial multicatheter brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1st Line Chemotherapy Alone or With Bevacizumab in Treating Older Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Chemotherapy ( FOLFIRI regimen, FOLFOX regimen or LV5FU2 regimen)|DRUG: Chemotherapy ( FOLFIRI regimen, FOLFOX regimen or LV5FU2 regimen) + bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Amino Acid and Chromium-picolinate Containing Drink on Glucose Metabolism
Status: COMPLETED
Conditions: Type 2 Diabetes|Prediabetes
Interventions: DIETARY_SUPPLEMENT: Amino Acid and chromium-picolinate containing drink|DIETARY_SUPPLEMENT: Placebo Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Veliparib Placebo|DRUG: Veliparib|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detective Flow Imaging Endoscopic Ultrasonography in Subepithelial Lesions
Status: RECRUITING
Conditions: Leiomyoma|GIST
Interventions: DIAGNOSTIC_TEST: DFI-EUS|DIAGNOSTIC_TEST: CE-EUS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of THRIVE During Apneic Oxygenation in General Anesthesia on Biomarkers
Status: COMPLETED
Conditions: Anesthesia|Oxygen Toxicity
Interventions: DEVICE: Apnoeic oxygenation using THRIVE|DEVICE: Endotracheal intubation and mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: DRUG: daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Safety, Tolerability, and Biosignature of Humanized Prebiotics in Healthy Adults
Status: RECRUITING
Conditions: Intestinal Health
Interventions: DIETARY_SUPPLEMENT: "Humanized" galacto-oligosaccharides (hGOS)|DIETARY_SUPPLEMENT: Galacto-oligosaccharides (GOS)|OTHER: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Long Term Effect, Safety and Metabolism of a Solifenacin Liquid Suspension in Participants 5 to 18 Years of Age With Neurogenic Detrusor Overactivity
Status: COMPLETED
Conditions: Neurogenic Detrusor Overactivity
Interventions: DRUG: Solifenacin succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-implant Tissues on Aesthetic Slim Abutment Galimplant (PSG)
Status: COMPLETED
Conditions: Dental Implant Failed|Dental Prosthesis Failure
Interventions: PROCEDURE: Straight abutment|PROCEDURE: Slim abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]
Status: COMPLETED
Conditions: Tobacco Use|Tobacco Smoking|Cigarette Smoking|Smokeless Tobacco Cessation
Interventions: OTHER: Electronic Cigarette|OTHER: Oral Nicotine Pouch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open-Label Study in HIV+ Patients to Determine the Effects of Nevirapine (Viramune) on the Pharmacokinetics of Clarithromycin and Activity of Cytochrome 3A4.
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Erythromycin|DRUG: Nevirapine|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Reducing Pain Levels and Increasing Comfort of Premature Infants During Aspiration
Status: NOT_YET_RECRUITING
Conditions: Pain|Premature Baby 26 to 32 Weeks|Premature Baby 33 to 36 Weeks|Aspiration
Interventions: OTHER: crochet octopus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of SI-B003 or BL-B01D1+SI-B003 in Patients With Unresectable Locally Advanced or Recurrent Metastatic HER2 Negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: BL-B01D1|DRUG: SI-B003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraumbilical Amino Acids and Glucose Supplementation Via Port by Severe IUGR in Human Fetuses
Status: COMPLETED
Conditions: Intrauterine Growth Restriction
Interventions: DEVICE: fetal nutrition port system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Boiled Tree Nut for Oral Immunotherapy in Food-allergic Children
Status: RECRUITING
Conditions: Food Allergy in Children|Food Allergy
Interventions: OTHER: Cashew oral immunotherapy|OTHER: Placebo oral immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT