pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Acute Pediatric Fracture Analgesia Study
Status: COMPLETED
Conditions: Fracture
Interventions: DRUG: ibuprofen|DRUG: acetamin w codeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Osteopathic Manipulation on Breathing Mechanics in a Healthy Population: A Randomized Controlled Study
Status: COMPLETED
Conditions: Respiratory Function Impaired
Interventions: OTHER: Osteopathic Manipulative Medicine|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Different Doses of BI 765063 Alone and in Combination With BI 754091 in Japanese Patients With Different Types of Advanced Cancer (Solid Tumors)
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: BI 765063|DRUG: BI 754091
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telephone Counseling or Standard Care in Patients Who Have Completed Treatment for Stages I, II, or III Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: BEHAVIORAL: Psychosocial Telephone Counseling (PTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Canagliflozin|DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Chlorhexidine-Based Bathing on Nosocomial Infections
Status: COMPLETED
Conditions: Nosocomial Bacteremia|Nosocomial Fungemia|MRSA Colonization|MRSA Infection|VRE Colonization|VRE Infection
Interventions: BEHAVIORAL: Daily bathing with Chlorhexidine based product
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Comparing Daratumumab, Lenalidomide, Bortezomib, and Dexamethasone (D-RVd) Versus Lenalidomide, Bortezomib, and Dexamethasone (RVd) in Subjects With Newly Diagnosed Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized Controlled Comparison of TERUMO SurFlash Plus Versus BD Insyte Autoguard in an Urban ED
Status: COMPLETED
Conditions: Catheters|Catheterization, Peripheral
Interventions: DEVICE: Terumo SurFlash Plus catheter|DEVICE: BD Insyte Autoguard catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Duration Treatment of Non-severe Community Acquired Pneumonia
Status: UNKNOWN
Conditions: Community Acquired Pneumonia
Interventions: RADIATION: Chest X-ray|BIOLOGICAL: blood sampling /Cell Counts/ C reactive protein (CRP)/Biochemistry|DRUG: Augmentin|DRUG: Placebo (for Augmentin)|DRUG: Beta-Lactams
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: B-lymphocyte Depletion Using Rituximab in Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME). A Randomized Phase-III Study.
Status: COMPLETED
Conditions: Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME)
Interventions: DRUG: Rituximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Immunotherapy for Peanut Allergy and Induction of Tolerance
Status: COMPLETED
Conditions: Peanut Hypersensitivity|Food Hypersensitivity|Food Allergy|Peanut Allergy
Interventions: DRUG: Liquid peanut extract (Peanut SLIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M. Avium WGS During Mav-PD Treatment
Status: RECRUITING
Conditions: Mycobacterium Avium|Mycobacterium Infections, Nontuberculous|Mycobacterium Infections|Nontuberculous Mycobacterial Lung Disease|Respiratory Tract Diseases
Interventions: OTHER: Whole genome sequencing testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment Of Anterior Chamber Configuration Changes After Phacoemulsification With Swept-Source Optical Coherence Tomography
Status: UNKNOWN
Conditions: Anterior Chamber Parameters|Phacoemulsification|Anterior Segment Swept-source Optical Coherence Tomography
Interventions: PROCEDURE: cataract surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SAW Lung Microbiome Study in Smokers and Never-smokers
Status: COMPLETED
Conditions: Smoking Cessation|Chronic Obstructive Pulmonary Disease (COPD)|Healthy|Microbial Colonization
Interventions: BEHAVIORAL: Smoking cessation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Superomedial Pedicle Versus Inferior Pedicle Techniques in Wise Pattern Reduction Mammaplasty :A Comparison Study
Status: UNKNOWN
Conditions: To Compare Complications of Both Techniques in Wise Pattern Reduction Mammaplasty and to Correlate Between Complications and Patient Mediated Factors
Interventions: PROCEDURE: Reduction mammaplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Stannous fluoride toothpaste|DRUG: Sodium fluoride toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antidepressants Trial in Parkinson's Disease
Status: COMPLETED
Conditions: Depression|Parkinson Disease
Interventions: DRUG: Nortriptyline|DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock
Status: UNKNOWN
Conditions: the Coagulolytic Balance|the Mortality Rate|the Performance Used to Evaluate the Principal Objective Are Technical Performances, Sensibility and Specificity of the Tests
Interventions: BIOLOGICAL: blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia.
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Normal saline|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-principle Study of Oral Treatment of Non-alcoholic Steatohepatitis With a Novel PDE4 Inhibitor ASP9831
Status: COMPLETED
Conditions: Non-Alcoholic Steatohepatitis
Interventions: DRUG: ASP9831|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of Electrodes Implanted in the Left Ventricle
Status: COMPLETED
Conditions: Heart Failure|Ventricular Dysfunction|Cardiomyopathies|Heart Diseases|Cardiovascular Diseases
Interventions: DEVICE: WiCS-LV system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NMF-CsA-Dupi Trial
Status: RECRUITING
Conditions: Dermatitis, Atopic
Interventions: DRUG: Topical corticosteroids|DRUG: Systemic cyclosporine|DRUG: Systemic dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Radial Extracorporeal Shockwave Therapy on Knee Osteoarthritis
Status: SUSPENDED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Active rESWT|DEVICE: Sham rESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Drug Utilization Study of Asenapine in the United Kingdom (P08308)
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Asenapine|DRUG: Aripiprazole|DRUG: Quetiapine|DRUG: Risperidone|DRUG: Olanzapine|DRUG: Ziprasidone|DRUG: Iloperidone|DRUG: Paliperidone|DRUG: Lurasidone|DRUG: Clozapine|DRUG: Amisulpride|DRUG: Sertindole|DRUG: Zotepine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study
Status: COMPLETED
Conditions: Cancer|Colon Cancer|Colorectal Cancer|Fever|Locally Advanced|Metastatic Colorectal Cancer|Neutropenia|Rectal Cancer
Interventions: DRUG: Pegfilgrastim|DRUG: Placebo|BIOLOGICAL: Bevacizumab|DRUG: Standard Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CLARA: Somatic and Germline Mechanisms That Impact Renal Cancer Immunotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cancer Metastatic
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Renal Blood Flow Using Contrast Enhanced Ultrasound for Differential Diagnosis of Acute Kidney Injury in Cirrhotic Patients: A Pilot Study
Status: UNKNOWN
Conditions: Liver Cirrhosis and Acute Kidney Injury
Interventions: DRUG: Definity ultrasound contrast agent
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Physician Acceptance of the NeuTrace System for Cardiac Electroanatomic Mapping
Status: RECRUITING
Conditions: Arrhythmias, Cardiac|Atrial Fibrillation|Atrial Flutter
Interventions: DEVICE: Electroanatomic mapping with the NeuTrace System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Platelet-Rich Plasma for Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence,Stress|Urinary Incontinence
Interventions: PROCEDURE: Platelet-rich plasma injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Art and Physical Therapy in Pediatric HCT
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplantation|Art Therapy|Physical Therapy
Interventions: BEHAVIORAL: Art and Physical Therapy|BEHAVIORAL: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Combination of Hdroxyurea and Thalidomide Over Either Hydroxyurea or Thalidomide Alone in the Treatment of Transfusion Dependent Thalassemia in Children: A Quasi-Randomised Clinical Trial
Status: RECRUITING
Conditions: Transfusion-dependent Thalassemia
Interventions: DRUG: Thalidomide|DRUG: Hydroxy Urea|DRUG: Combinations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dose Response Curve - Sacral Nerve Stimulation for Faecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence
Interventions: DEVICE: Sensory Threshold|DEVICE: 75% of sensory threshold - Amplitude|DEVICE: 50% of sensory threshold - Amplitude
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Oxervate|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Acupuncture on Nausea, Vomiting, Pain, PGE2 and IL 6 in Septorhinoplasty
Status: COMPLETED
Conditions: Pain|Acupuncture
Interventions: DEVICE: Acupuncture Pres Needle: 0.22x1.5 mm needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PATH Study: People With Injecting Related Infections: Assessing Treatment Outcomes for Those Who Are Hospitalised.
Status: NOT_YET_RECRUITING
Conditions: Invasive Fungal Infections|Invasive Bacterial Infection|Injection Site Infection|Infection, Bacterial|Infection, Fungal|Infection, Soft Tissue
Interventions: OTHER: Observational
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Vasopressin in the Social Deficits of Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DRUG: Vasopressin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CSL312 Safety, Pharmacokinetics, and Pharmacodynamics in Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: CSL312|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-line Combination of Capecitabine and Oxaliplatin Plus Bevacizumab in Elderly Patients With Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Elderly Metastatic Colorectal Cancer Patients
Interventions: DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Anorexia Nervosa in Children and Adolescents: An Integrated Family Based and Metacognitive Approach
Status: ACTIVE_NOT_RECRUITING
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Family based therapy- Metacognitive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Epicardial Versus Conventional Lead Placement in Cardiac Resynchronization Therapy
Status: COMPLETED
Conditions: Cardiac Resynchronization Therapy|Heart Failure
Interventions: PROCEDURE: Primary epicardial placement of left ventricular lead|PROCEDURE: Transvenous placement of left ventricular lead
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Molecular Breast Imaging as a Screening Tool for Women With Dense Breasts
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Molecular Breast Imaging|DEVICE: Conventional Mammography|DRUG: Technetium (99mTc) sestamibi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Association of Polymorphisms in the Androgen Receptor Gene and Finasteride Response in Women With Androgenetic Alopecia
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: Finasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Enhancement Through Model-based and Individualized Neurostimulation
Status: RECRUITING
Conditions: Transcranial Electrical Stimulation (tES)
Interventions: DEVICE: Transcranial electrical stimulation (tES) including SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of Enhanced Terminal Room Disinfection to Prevent Healthcare-associated Infections (HAIs)
Status: COMPLETED
Conditions: Multidrug Resistant Organisms|Healthcare Associated Infections
Interventions: OTHER: Quaternary ammonium|OTHER: Bleach|OTHER: Quaternary ammonium and UV-C light|OTHER: Bleach and UV-C light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Randomized Controlled Field Trial of a Probiotics to Assess Its Role in Preventig Diarrhoea
Status: UNKNOWN
Conditions: Diarrhea
Interventions: DIETARY_SUPPLEMENT: Probiotic (Yakult)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer
Status: COMPLETED
Conditions: Metastatic Cancer|Pulmonary Complications
Interventions: OTHER: talc|PROCEDURE: dyspnea management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Pharmacokinetics and Immunogenicity Study of Abatacept Administered Intravenously to Treat Active Polyarticular-course Juvenile Idiopathic Arthritis in Japan
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of hSTC810 in Combination With Paclitaxel in Relapsed or Refractory Extensive Stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Extensive Stage Small Cell Lung Cancer
Interventions: DRUG: hSTC810 400 mg + Paclitaxel|DRUG: hSTC810 800 mg + Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Iron Isomaltoside 1000 (Monofer) in Postpartum Anemia
Status: COMPLETED
Conditions: Postpartum Anemia
Interventions: DRUG: Iron isomaltoside 1000|DRUG: Ferrous sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN
Status: WITHDRAWN
Conditions: Squamous Cell Carcinoma of Head and Neck|Locally Advanced Head and Neck Squamous Cell Carcinoma|Recurrent Head and Neck Squamous Cell Carcinoma
Interventions: BIOLOGICAL: RP3|OTHER: CCRT(concurrent chemoradiation therapy)|OTHER: carboplatin and paclitaxel|BIOLOGICAL: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gallium Ga 68 DOTA-NeoBOMB1 and Gallium Ga 68 PSMA-R2 PET/MRI in Diagnosing Participants With Recurrent Prostate Cancer
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|PSA Progression|Recurrent Prostate Carcinoma
Interventions: DRUG: Gallium Ga 68 DOTA-NeoBOMB1|DEVICE: Gallium Ga 68 PSMA-R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Safety and Pharmacokinetics of BCD-100 (Anti-PD-1) Monotherapy as Second Line Treatment in Patients With Non-Small Cell Lung Cancer (DOMINUS)
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer Stage IIIB|Non-Small Cell Carcinoma of Lung, TNM Stage 4
Interventions: DRUG: BCD-100|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of ONCT-534 in Subjects With Metastatic Castration-resistant Prostate Cancer.
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: ONCT-534
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of SGLT-2 Inhibition on Hepatic Glucose and Energy Metabolism
Status: UNKNOWN
Conditions: Type 2 Diabetes|Metabolically Healthy Controls
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Caregiver Peer Support and ART Adherence Among Children
Status: RECRUITING
Conditions: HIV|Adherence
Interventions: BEHAVIORAL: Champion Caregiver peer mentoring support to caregivers on child care and medication adherence to enhance achievement of viral suppression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reliability of the Freestyle Libre CGM in the Inpatient Setting During the COVID-19 Surge
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Freestyle Libre 14 day CGM system|DEVICE: Accuchek Inform II platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Root Canal Treatment With TotalFill® Bioceramic Sealer and AH Plus® Sealer
Status: COMPLETED
Conditions: Root Canal Obturation
Interventions: DEVICE: TotalFill® Bioceramic sealer|DEVICE: AH plus® sealer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Describe the Effect of rhLH Supplementation in Women With Hyporesponse to rhFSH After Pituitary Downregulation
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Luveris
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Determine the Clinical Cure Rate of Therapeutic up Front Shave Removal of Basal Cell Carcinoma of the Skin With Long Term Follow up to Evaluate Recurrence
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: PROCEDURE: Deep shave removal using a blue surgical blade
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.
Status: RECRUITING
Conditions: Hyperhomocysteinemia
Interventions: DIETARY_SUPPLEMENT: B-TMG supplementation|DIETARY_SUPPLEMENT: B-SAM supplementation|OTHER: B-TMG placebo|OTHER: B-SAM placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Predialytic Oral Protein on Nutritional Status and Quality of Life in HD Patients
Status: COMPLETED
Conditions: Hemodialysis Complication
Interventions: DIETARY_SUPPLEMENT: oral protein nutritional supplement (Fresubin protein powder)|OTHER: routine nutrition regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Efficacy and Safety of Filgotinib in Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: filgotinib|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Local Effect and Safety of a Single PPC-5650 Dose on Reflux Pain During Pain Stimulation in the Esophagus
Status: COMPLETED
Conditions: Gastroesophageal Reflux|Gastroesophageal Reflux Disease
Interventions: DRUG: PPC-5650|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Caffeine Reduce Dipyridamole-Induced Protection Against Ischemia-Reperfusion Injury?
Status: COMPLETED
Conditions: Cardiovascular Disease|Ischemia-Reperfusion Injury
Interventions: DRUG: Dipyridamole|DRUG: caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Animated Home-based Physical Exercise Program as a Treatment Option for Patients With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: animated home-based exercises (Wii-fit)|PROCEDURE: conventional home-based exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase I/II Trial Investigating LOAd703 in Combination With Atezolizumab in Malignant Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: GENETIC: delolimogene mupadenorepvec|BIOLOGICAL: atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ERtugliflozin triAl in DIabetes With Preserved or Reduced ejeCtion FrAcTion mEchanistic Evaluation in Heart Failure
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Heart Failure
Interventions: DRUG: Ertugliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib
Status: TERMINATED
Conditions: Inflammatory Bowel Diseases
Interventions: BIOLOGICAL: SHINGRIX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drug Repurposing Using Metformin for Improving the Therapeutic Outcome in Multiple Sclerosis Patients
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: MetFORMIN 1000 Mg Oral Tablet|DRUG: Interferon beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infection|Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Plasmablastic Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Non-Hodgkin Lymphoma|Recurrent Burkitt Lymphoma|Recurrent Follicular Lymphoma|Stage III Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Follicular Lymphoma|Stage IV Mantle Cell Lymphoma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|DRUG: Carmustine|DRUG: Cytarabine|DRUG: Etoposide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Lentivirus Vector CCR5 shRNA/TRIM5alpha/TAR Decoy-transduced Autologous CD34-positive Hematopoietic Progenitor Cells|DRUG: Melphalan|PROCEDURE: Peripheral Blood Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sildenafil Efficacy Study on Time Walk From Peripheral Arterial Desease Patients (Stade II) With Arterial Claudication
Status: COMPLETED
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DRUG: Sildenafil 100mg single oral dose|DRUG: Placebo, Oral intake single dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer
Status: COMPLETED
Conditions: Unresectable Esophageal Cancer
Interventions: DRUG: Toripalimab|DRUG: Paclitaxel/Cisplatin|RADIATION: Intensity-modulated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vestibular Treatment in Adolescents Following Sport Related Concussion
Status: COMPLETED
Conditions: Vestibular Disorder
Interventions: BEHAVIORAL: Vestibular Exercise Intervention|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Tafenoquine Plus Standard of Care Versus Placebo Plus Standard of Care for Babesiosis
Status: RECRUITING
Conditions: Babesiosis
Interventions: DRUG: Tafenoquine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Docetaxel, Oxaliplatin, Capecitabine, Fluorouracil, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction
Status: COMPLETED
Conditions: Adenocarcinoma of the Gastroesophageal Junction|Esophageal Cancer|Gastric Cancer
Interventions: DRUG: capecitabine|DRUG: docetaxel|DRUG: fluorouracil|DRUG: oxaliplatin|RADIATION: radiation therapy|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Telintra for Treatment of Chemotherapy Induced Neutropenia in Patients With Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: ezatiostat hydrochloride (Telintra®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Age-dependent Effects of Smoked and Oral Delta-9-THC
Status: NOT_YET_RECRUITING
Conditions: Pain|Abuse, Drug|Intoxication; Cannabinoids
Interventions: DRUG: Cannabis|DRUG: Dronabinol|DRUG: Smoked Placebo|DRUG: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bioavailability of Levonorgestrel and Ethinyl Estradiol Tablets 15.0 mg/0.03 mg With Regards to Reference Product
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg Test Drug|DRUG: Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg Reference Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Camrelizumab(SHR-1210) Combined With GEMOX in Patients With Relapsed or Refractory Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Camrelizumab(SHR-1210)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Nebivolol Versus Metoprolol on Quality of Life
Status: TERMINATED
Conditions: Transplant; Failure, Kidney|Hypertension
Interventions: DRUG: Nebivolol|DRUG: Metoprolol succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sacituzumab Govitecan in Combination With Cisplatin in Platinum Sensitive Recurrent Ovarian and Endometrial Cancer
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer|Malignant Neoplasm of Uterus
Interventions: DRUG: Sacituzumab|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation and Modification of Surgeon Ergonomics in the Operation Room Using Artificial Intelligence Analytics
Status: NOT_YET_RECRUITING
Conditions: Work Related Upper Limb Disorder|Musculoskeletal Pain
Interventions: BEHAVIORAL: Education presentation of surgical ergonomics|BEHAVIORAL: Summary of Ergonomic Measurement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Phenylephrine Versus Norepinephrine on Venous Return
Status: UNKNOWN
Conditions: Arterial Hypotension
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of TEAS on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy
Status: RECRUITING
Conditions: Liver Cancer
Interventions: DEVICE: transcutaneous electrical acupoint stimulation|DEVICE: sham transcutaneous electrical acupoint stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Myoma Removal on Blood Pressure and Erythropoetin Level
Status: COMPLETED
Conditions: Myoma|Hypertension
Interventions: PROCEDURE: myoma removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Vitamin D Supplementation in HIV-infected Youth
Status: COMPLETED
Conditions: HIV Disease|Vitamin D Deficiency|Hypovitaminosis D|Hyperparathyroidism
Interventions: DRUG: oral cholecalciferol 1000000 UI (vitamin D3)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Lung Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Brain|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: OTHER: Questionnaire Administration|RADIATION: Stereotactic Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Hemostasis Following the Use of the AQUABEAM® System for the Treatment of Benign Prostatic Hyperplasia III
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: AQUABEAM System followed by catheter without hemostatic agent|DEVICE: AQUABEAM System followed by catheter with hemostatic agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of ATx201 in Subjects With Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: ATx201 2% Cream|DRUG: ATx201 Cream Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Immunological Effects of a Combined Treatment With Radiation and Cyclophosphamide in Metastasized Breast Cancer Patients
Status: WITHDRAWN
Conditions: Radiotherapy|Immunology
Interventions: DRUG: Cyclophosphamide|RADIATION: Stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Investigate Collagen Matrix 10808 for Soft Tissue Volume Augmentation Around Single Implants
Status: COMPLETED
Conditions: Tooth Loss|Soft Tissue Deficiency
Interventions: DEVICE: Collagen Matrix 10808|PROCEDURE: Connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a New Method to Detect Residual Tumours During Surgery for Prostate Cancer Using Confocal Microscopy
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: NeuroSAFE procedure|DIAGNOSTIC_TEST: LaserSAFE procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Vaccine Therapy in Treating Patients With Transitional Cell Carcinomas
Status: COMPLETED
Conditions: Transitional Cell Carcinoma
Interventions: BIOLOGICAL: TICE®-strain BCG|BIOLOGICAL: NY-ESO-1 protein|BIOLOGICAL: sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese Shield
Status: RECRUITING
Conditions: Malaria, Vivax
Interventions: DRUG: PART|DRUG: Malakit|OTHER: CROSS-SECTIONAL PRE- AND POST-INTERVENTION SURVEYS|OTHER: QUALITATIVE STUDY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic and Respiratory Effects of Esophageal Dilation in Children
Status: COMPLETED
Conditions: Obstruction of Esophagus|Respiratory Complication|Hemodynamic Instability
Interventions: PROCEDURE: endoscopic dilatation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Improved Pain Management in Knee Osteoarthritis-related Surgeries
Status: COMPLETED
Conditions: Knee Osteoarthritis|Total Knee Arthroplasty|Unicompartmental Knee Arthroplasty|High Tibial Osteotomy|Pain Management
Interventions: PROCEDURE: Preoperative pain managment|PROCEDURE: Intraoperative pain managment|PROCEDURE: Postoperative pain managment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Chlorhexidine as a Final Irrigant in Single-visit Root Canal Treatment
Status: COMPLETED
Conditions: Root Canal Infection
Interventions: OTHER: EDTA|OTHER: NaOCl|OTHER: CHX|OTHER: Calcium hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Study on the Effect of Oesophageal Temperature on the Incidence of Esophageal Lesions After AF Ablation
Status: COMPLETED
Conditions: Cardiac Arrhythmias|Atrial Fibrillation|Esophageal Ulcer
Interventions: DEVICE: multipolar and self expandable thermometer|DEVICE: Single probe thermometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Blocking the Glossopharyngeal Nerve on Gastroesophageal Reflux Disease
Status: NOT_YET_RECRUITING
Conditions: Dysphagia
Interventions: BEHAVIORAL: Rehabilitation therapy|DRUG: Lidocaine|PROCEDURE: Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fludrocortisone and Hydrocortisone in Healthy Volunteers With Aldosterone Induced Suppression
Status: TERMINATED
Conditions: Renin Angiotensin
Interventions: DRUG: Fludrocortisone|DRUG: Hydrocortisone|DRUG: Placebo of Fludrocortisone|DRUG: Placebo of Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Allogeneic or Haploidentical Stem Cell Transplant Followed By High-Dose Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: busulfan|DRUG: fludarabine phosphate|RADIATION: total-body irradiation (TBI)|PROCEDURE: Stem cell transplant|DRUG: cyclophosphamide|DRUG: tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Enalapril, Losartan or Not Antihypertensive on the Oxidative Status in Renal Transplant Recipients
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DRUG: Angiotensin converting enzyme inhibitor|DRUG: Angiotensin Receptor Blockers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of IRL790 in Parkinson's Disease Dyskinesia
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Mesdopetam (IRL790)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Valproic Acid for Idiopathic Nephrotic Syndrome
Status: UNKNOWN
Conditions: Idiopathic Nephrotic Syndrome|Focal Segmental Glomerulosclerosis|Minimal Change Disease
Interventions: DRUG: Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vestibular Rehabilitation Strategies in PTSD Effectiveness of Carrick Brain Centers Strategies Vestibular Rehabilitation Treatment in PTSD Patients Who Have Suffered Combat Related Traumatic Brain Injuries
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder PTSD
Interventions: PROCEDURE: Vestibular Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Immunity: Photosynthesis Versus Supplementation
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D|RADIATION: UVR (Solar simulated radiation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Impact on Calcium Levels When Hemodialysis Patients With Secondary Hyperparathyroidism (SHPT) Switch From Cinacalcet to Etelcalcetide
Status: COMPLETED
Conditions: Hyperparathyroidism, Secondary
Interventions: DRUG: Etelcalcetide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus Disease
Status: TERMINATED
Conditions: Cytomegalovirus Disease
Interventions: DRUG: Brincidofovir|DRUG: Valganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of GSK2256098 and Trametinib in Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Adenocarcinoma
Interventions: DRUG: GSK2256098|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Clinical Feasibility of the New Indwelling Provox Vega 20 Voice Prosthesis
Status: TERMINATED
Conditions: Total Laryngectomy
Interventions: DEVICE: Provox Vega voice prosthesis (20 Fr)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Microbiome|Metagenome|Immunotherapy|Melanoma
Interventions: BIOLOGICAL: Collection of stool, blood (PBMC) and biopsy (FFPE)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: mp3 vs Apatos in Post-extractive Sockets
Status: COMPLETED
Conditions: Alveolar Bone Loss
Interventions: DEVICE: alveolar bone preservation with mp3|DEVICE: alveolar bone preservation with apatos|DEVICE: stabilization with membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study for a Gamma Delta T Cell Product Used With Low Dose Radiotherapy in Patients With Stage 4 Metastatic NSCLC
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung Cancer
Interventions: BIOLOGICAL: KB-GDT-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses of BI 10773 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 10773 single rising dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: SihatMand Khandaan Healthy Families for Pakistan
Status: ACTIVE_NOT_RECRUITING
Conditions: Contraception|Contraception Behavior|Reproductive Behavior|Maternal Behavior
Interventions: BEHAVIORAL: Uptake of quality Reproductive health and Family planning products, information and Services|BEHAVIORAL: Capacity building of facility based and community based healthcare providers (public and private sector) on FP /SRH|BEHAVIORAL: Adolescent Engagement|BEHAVIORAL: Renovation and Refurbishment of selected healthcare facilities|BEHAVIORAL: Use of Data for Effective Decision-making|BEHAVIORAL: Procurement of FP/SRH medical supplies and equipment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH