pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: P3 Study of Umbilical Cord Blood Cells Expanded With MPCs for Transplantation in Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Non-Hodgkin's Lymphoma|Hodgkin's Disease
Interventions: BIOLOGICAL: Infusion of one MPC expanded cord unit and one unexpanded cord unit|BIOLOGICAL: Infusion of two unexpanded cord blood units.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated Lymphoma
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma|High Grade B-Cell Lymphoma w/MYC & BCL2 or BCL6 Rearrangements|High Grade B-Cell Lymphoma w/MYC, BCL2 & BCL6 Rearrangements|Double Expressor Lymphoma|High-grade B-cell Lymphoma
Interventions: DRUG: Prednisone|DRUG: Prednisolone|DRUG: Methylprednisolone|BIOLOGICAL: Rituximab|DRUG: Polatuzumab Vedotin|DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Detecting Lactate and Bicarbonate in Participants With Central Nervous System Tumors
Status: COMPLETED
Conditions: Malignant Central Nervous System Neoplasm|Metastatic Malignant Neoplasm in the Central Nervous System
Interventions: OTHER: Gadolinium|DRUG: Hyperpolarized Carbon C 13 Pyruvate|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Magnetic Resonance Spectroscopic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Life After Stopping Tyrosine Kinase Inhibitors Study (The LAST Study)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Chronic
Interventions: DRUG: Imatinib (Stopping their TKI)|DRUG: Dasatinib (Stopping their TKI)|DRUG: Nilotinib (Stopping their TKI)|DRUG: Bosutinib (Stopping their TKI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics, Safety And Toleration Of Maraviroc Administered To Subjects With Various Degrees Of Renal Impaired And Normal Renal Function
Status: COMPLETED
Conditions: Human Immunodeficiency Virus (HIV) Infection
Interventions: DRUG: Maraviroc|DRUG: Maraviroc|DRUG: Ritonavir|DRUG: Saquinavir|DRUG: Maraviroc|DRUG: Ritonavir|DRUG: Saquinavir|DRUG: Maraviroc|DRUG: Ritonavir|DRUG: Saquinavir|DRUG: Maraviroc|DRUG: Maraviroc|DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Darbepoetin Alfa in Anemic Subjects Not Receiving Chemotherapy Who Have Completed the 20010103 Study
Status: COMPLETED
Conditions: Anemia|Cancer
Interventions: DRUG: Placebo|DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib Followed By Surgery in Treating Women With Ductal Carcinoma In Situ of the Breast
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: gefitinib|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of L-Carnitine Supplementation on Respiratory Distress Syndrome
Status: WITHDRAWN
Conditions: Premature Birth
Interventions: DRUG: Dexamethasone|DRUG: L-Carnitine 1G/5mL Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HPV Vaccine Communication ECHO for Primary Care Clinics
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Papillomavirus Vaccines|Adolescent Health Services
Interventions: OTHER: Project ECHO|OTHER: Announcement Approach Training|OTHER: Recall notices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Lenalidomide Plus CHOP vs CHOP in Patients With Untreated Peripheral T-Cell Lymphoma
Status: RECRUITING
Conditions: Peripheral T-Cell Lymphoma|Lenalidomide|CHOP
Interventions: DRUG: Lenalidomide|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Participants Undergoing Hematopoietic Cell Transplants (HCTs) (V212-001)
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: V212|BIOLOGICAL: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Anlotinib Plus Sintilimab as First-line Treatment for Advanced Non Clear Cell Renal Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Non Clear Cell Renal Carcinoma
Interventions: DRUG: Anlotinib plus Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Tracheostomy in Ventilated Stroke Patients 2
Status: COMPLETED
Conditions: Ischemic and Hemorrhagic Stroke, Subarachnoid Hemorrhage
Interventions: PROCEDURE: Tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testosterone-induced Muscle Memory and Underlying Mechanisms
Status: NOT_YET_RECRUITING
Conditions: Skeletal Muscle Physiology
Interventions: DRUG: Testosterone Undecanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Physician Clinical Trial Policy (CTP) Neurological Ischemia Lower Extremity Pain and Swelling
Status: ENROLLING_BY_INVITATION
Conditions: Lower Extremity Swelling Acute
Interventions: DEVICE: Anodyne
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Diagnosis of Heparin-Induced Thrombocytopenia in Surgical Critically Ill Patients
Status: COMPLETED
Conditions: Heparin-induced Thrombocytopenia (HIT)
Interventions: OTHER: HEP score|OTHER: 4Ts score|OTHER: ID-PaGIA test|OTHER: HIT-Ab(PF4-H) test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Effect of Sevoflurane and Propofol Hypotensive Anesthesia on Blood Antioxidant Levels and HIF 1 Levels
Status: SUSPENDED
Conditions: Hypoxemia During Surgery|Hypoxia
Interventions: PROCEDURE: Mean Blood Pressure (MBP)|DRUG: Add to 0.5 mcg / kg fentanyl.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence
Status: NOT_YET_RECRUITING
Conditions: Velocity-time Integral Measurement|Critically Ill Patients|Tissue Hypoperfusion
Interventions: OTHER: Fluid challenge (cristalloids) OR passive leg raising
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of Performing a Rapid Antibiotic Susceptibility Test on Antibiotic Therapy Adaptation in Adult Patients With Enterobacterales Bacteremia
Status: NOT_YET_RECRUITING
Conditions: Bacteremia
Interventions: DIAGNOSTIC_TEST: Antibiotic susceptibility testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and Pharmacokinetics of Single Doses of TS-134 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TS-134|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oligofructose-enriched Inulin for the Treatment of Mild to Moderate Active Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Synergy1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: APOL1 Genetic Testing Program for Living Donors
Status: RECRUITING
Conditions: Chronic Kidney Diseases|Apolipoprotein L1|Kidney Transplantation
Interventions: BEHAVIORAL: Components of Genetic Counseling|DIAGNOSTIC_TEST: APOL1 genetic testing|OTHER: EHR integration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Preliminary Clinical Study on the Effect of L-ornithine on the Efficacy of Ustekinumab in Patients With Crohn's Disease
Status: RECRUITING
Conditions: Mild to Severe Crohns Disease
Interventions: DIETARY_SUPPLEMENT: Now Foods L-Ornithine Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selection of Patients With Chronic Inflammatory Rheumatism Requiring Management During the COVID-19 Pandemia
Status: COMPLETED
Conditions: Covid19|Inflammatory Rheumatism|Rheumatoid Arthritis|Spondyloarthritis|Inflammatory Arthritis
Interventions: OTHER: SePaRIC-Covid19 cohort
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Invasive Breast Carcinoma|Metastatic Triple-Negative Breast Carcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Computed Tomography|BIOLOGICAL: Durvalumab|DRUG: Gemcitabine Hydrochloride|PROCEDURE: Magnetic Resonance Imaging|DRUG: Nab-paclitaxel|BIOLOGICAL: Personalized Synthetic Long Peptide Vaccine|DRUG: Poly ICLC|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Community-based Nursing Intervention on Mortality in Chronically Ill Older Adults
Status: UNKNOWN
Conditions: Heart Failure|Coronary Disease|Diabetes Mellitus|Asthma|Hypertension|Hypercholesterolemia
Interventions: OTHER: Community-based nurse care management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre Diabetes|Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin + Healthy diet|DRUG: Metformin + Personalized diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Telehealth Pilot for Veterans With Chronic Multi-Symptom Illness.
Status: UNKNOWN
Conditions: Chronic Multisymptom Illness
Interventions: BEHAVIORAL: Directed instruction of the combined intervention of physical activity and mindfulness meditation|BEHAVIORAL: Self-guided practice of the combined intervention of physical activity and mindfulness meditation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of the Effectiveness of a Program of Emotional Intelligence in Adolescents With Type 1 Diabetes (INTEDI)
Status: UNKNOWN
Conditions: Type1 Diabetes Mellitus
Interventions: BEHAVIORAL: Emotional abilities training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Cohort Study of Correlation Between Mast Cells and Prognosis in Patients With Acute Myocardial Infarction
Status: NOT_YET_RECRUITING
Conditions: Inflammation|Acute ST Segment Elevation Myocardial Infarction|Prognosis
Interventions: DIAGNOSTIC_TEST: Tryptase
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Proof of Concept Creatine Supplementation for Homocystinuria Study
Status: RECRUITING
Conditions: Homocystinuria
Interventions: DIETARY_SUPPLEMENT: Creatine|DIETARY_SUPPLEMENT: Dietary methionine tracer and protein intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A One-Arm Exploratory Clinical Trial of Apatinib Plus Gemcitabine in Patients With Advanced Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Apatinib|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pectoral Block for Breast Augmentation Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Anesthesia; Regional
Interventions: PROCEDURE: PEC 1 block|DRUG: Bupivacaine with epinephrine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does the Application of Cold Decreases the Pain Associated in the Pose of a Patch of Capsaicine at High Concentration on the Carrier Patients of Localized Neuropathic Pains ? - DIDOCAP
Status: COMPLETED
Conditions: Localized Neuropathic Pain
Interventions: OTHER: refrigerated cushion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess the Effect of StemAlive® Supplement on the Levels of Stem Cells in Human Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: StemAlive®|DIETARY_SUPPLEMENT: Placebo (For StemAlive®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Energetic Response to Feeding and Exercise in SCI
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Seated control (CON)|BEHAVIORAL: Moderate intensity continuous (MICT)|BEHAVIORAL: High intensity interval training (HIIT)|BEHAVIORAL: Circuit resistance training (CRT)|OTHER: Liquid Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Refractory Acute Myeloid Leukemia|Relapsed Acute Myeloid Leukemia|Acute Leukemia of Ambiguous Lineage
Interventions: DRUG: Revumenib|DRUG: Venetoclax|DRUG: Azacitidine|DRUG: intrathecal (IT) chemotherapy|DRUG: Cytarabine|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Midazolam Administered as a Solution by Conventional Syringe or ZENEO®
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 2 ml of DORMICUM® Midazolam Hydrochloride (15 mg/3 mL)|COMBINATION_PRODUCT: ZENEO® Midazolam (10 mg/0.625 mL) on bare skin in thigh|COMBINATION_PRODUCT: ZENEO® Midazolam (10 mg / 0.625 mL) on bare skin in ventrogluteal area|COMBINATION_PRODUCT: ZENEO® Midazolam (10 mg / 0.625 mL) through clothing in thigh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irrisept C.Acnes Study
Status: COMPLETED
Conditions: Rate of Positive Culture Growth for C.Acnes From Specimens Obtained From the Shoulders of Patients Undergoing Primary Shoulder Arthroplasty
Interventions: DRUG: Antiseptic Cleanser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Auditory Brainstem Implant (ABI) in Adult Non-Neurofibromatosis Type 2 Subjects
Status: TERMINATED
Conditions: Bilateral Hearing Loss for Causes Other Than Tumors
Interventions: DEVICE: Nucleus 24 (discontinued) and ABI541 Auditory Brainstem Implants (ABI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Controlled Trial of Intubation With the McGrath Series 5 Video Laryngoscope vs the Macintosh Laryngoscope
Status: COMPLETED
Conditions: Tracheal Intubation
Interventions: DEVICE: McGrath|DEVICE: Tracheal intubation using Macintosh Laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Impact, Safety, Tolerability and Immunogenicity of the Coronavac Vaccine in Kidney Transplant Recipients
Status: UNKNOWN
Conditions: SARS-CoV Infection|Coronavirus Infection|Vaccine Adverse Reaction
Interventions: BIOLOGICAL: Coronavac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy
Status: COMPLETED
Conditions: Oral Nimodipine|Milrinone|Vascular Spasm After Traumatic Subarachnoidhaemorrhage
Interventions: DRUG: nimodipine|DRUG: Oral Nimodipine and milrinone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function
Status: COMPLETED
Conditions: Endothelial Dysfunction|Hyperhomocysteinemia|Hypertension Grade I, Subgroup "Borderline" (WHO)
Interventions: DIETARY_SUPPLEMENT: Verum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Terbinafine Compared to Griseofulvin in Children With Tinea Capitis
Status: COMPLETED
Conditions: Tinea Capitis
Interventions: DRUG: Terbinafine hydrochloride (HCl)|DRUG: Griseofulvin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Voice Amplifiers and Personal Communication Systems in Individuals With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson's Disease|Dysarthria
Interventions: DEVICE: ChatterVox|DEVICE: Easy Listener FM system (Phonic Ear Corp.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Aflibercept FYB203 Biosimilar in Comparison to Eylea® in Patients With Neovascular Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: FYB203 (Proposed aflibercept biosimilar)|DRUG: Eylea® (Aflibercept)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aliskiren in Patients With Mild to Moderate Hypertension During Exercise
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Aliskiren|DRUG: Valsartan|DRUG: Placebo to aliskiren|DRUG: Placebo to valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of Laser, Extracorporeal Shockwave Therapy and Exercise Therapy on Plantar Fasciitis Outcomes
Status: COMPLETED
Conditions: Plantar Fascitis
Interventions: OTHER: Exercises|OTHER: MLS Laser Treatment|OTHER: ESWT treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Engaging Male Caregivers in Effective Prevention Programming to Reduce Risk of Violence and Violence-Related Injury
Status: COMPLETED
Conditions: Child Maltreatment|Parenting
Interventions: BEHAVIORAL: Behavioral Parent Support|BEHAVIORAL: Shared Parent-Child Activities|BEHAVIORAL: COACHES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: COVID-19: A Trial Studying the SARS-CoV-2 mRNA Vaccine CVnCoV to Learn About the Immune Response, the Safety, and the Degree of Typical Vaccination Reactions When CVnCoV is Given at the Same Time as a Flu Vaccine Compared to When the Vaccines Are Separately Given in Adults 60 Years of Age and Older
Status: WITHDRAWN
Conditions: SARS-CoV-2 Infection|Coronavirus Disease 2019 (COVID-19)
Interventions: BIOLOGICAL: SARS-CoV-2 mRNA Vaccine (CVnCoV)|BIOLOGICAL: Quadrivalent influenza vaccine (QIV)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer
Status: TERMINATED
Conditions: Rectal Cancer
Interventions: DRUG: CRLX101|DRUG: Capecitabine|RADIATION: Radiotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitality Health Incentives for Physical Activity
Status: WITHDRAWN
Conditions: Obesity
Interventions: BEHAVIORAL: Discovery Vitality base program|BEHAVIORAL: Communication|BEHAVIORAL: Charitable Incentive|BEHAVIORAL: Prize Draw Incentive|BEHAVIORAL: Direct Payment|BEHAVIORAL: Free Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 1b/2a Study to Evaluate Safety and Efficacy of KPG-818 in SLE
Status: COMPLETED
Conditions: SLE; Drug
Interventions: DRUG: KPG-818 low dose|DRUG: KPG-818 mid dose|DRUG: KPG-818 high dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Tolerability and Pharmacokinetics of TQB2916 Injection in Patients With Advanced Malignant Tumors
Status: UNKNOWN
Conditions: Advanced Tumors
Interventions: DRUG: TQB2916 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dedicated Drug-Drug Interaction (DDI) Study in Healthy Volunteers
Status: COMPLETED
Conditions: Drug Drug Interaction
Interventions: DRUG: Pirfenidone 267 mg Oral Tablet|DRUG: Nintedanib 150 mg Oral Capsule|DRUG: BLD-0409 750 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Molecular Mechanisms Underlying the Cross-neutralizing Capacity of AS04-adjuvanted HPV Vaccine (Cervarix®) in Comparison With the Aluminiumhydroxyphosphate Sulphate Adjuvanted HPV Vaccine (Gardasil®)
Status: COMPLETED
Conditions: Infection With Human Papillomavirus
Interventions: BIOLOGICAL: cervarix|BIOLOGICAL: Gardasil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Probenecid|DRUG: Ciclosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Acute Traumatic Brain Injury|Subarachnoid Hemorrhage
Interventions: DIAGNOSTIC_TEST: The predictive value russian rendition the FOUR score.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac Patients
Status: COMPLETED
Conditions: Depression|Generalized Anxiety Disorder|Panic Disorder
Interventions: OTHER: Collaborative care|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment for Migraine and Mood
Status: RECRUITING
Conditions: Migraine|Depressive Symptoms
Interventions: BEHAVIORAL: MBCT-Telephone|BEHAVIORAL: MBCT-Video|BEHAVIORAL: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia.
Status: COMPLETED
Conditions: BK Virus Nephropathy After Kidney Transplantation
Interventions: DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Topical Acyclovir in Healthy Volunteers
Status: COMPLETED
Conditions: Dermatologic Disorders
Interventions: DRUG: 5% Zovirax® cream|DRUG: 5% Aciclostad cream|DRUG: 5% Aciclovir cream 1A Pharma|DRUG: 5% Zovirax Cold Sore Cream|DRUG: 5% Zovirax® cream (Austria)|PROCEDURE: OFM|DEVICE: OFM Probe|DEVICE: OFM Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on the Efficacy and Safety of Rechargeable Implantable DBS System in the Treatment of Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Rechargeable implantable deep brain stimulation system|DEVICE: Rechargeable implantable deep brain stimulation system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx
Status: RECRUITING
Conditions: Parenting|Covid19
Interventions: BEHAVIORAL: CARE Program and Valera Application with care manager functionality|BEHAVIORAL: Valera Application with care manager functionality|BEHAVIORAL: CARE Program|BEHAVIORAL: Valera Application|BEHAVIORAL: CARE Program and Valera Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Pharmacokinetics of Doravirine (MK-1439) in Participants With Severe Renal Impairment (MK-1439-051)
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Doravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindful Motivation for Reducing Binge Eating
Status: NOT_YET_RECRUITING
Conditions: Binge Eating|Psychological|Health Behavior|Weight, Body
Interventions: BEHAVIORAL: Meditation|BEHAVIORAL: Mindful Motivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interactive Care Coordination and Navigation:RCT To Assess the Impact of a mHealth Intervention for Homeless Individuals
Status: COMPLETED
Conditions: Number of Emergency Department and Hospital Visits Among Adults Experiencing Homelessness|Medication Adherence|Social Support|Pyschological Distress|Attainment of Social Needs (i.e., Housing, Employment, Receipt of Benefits)
Interventions: BEHAVIORAL: iCAN Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Status: COMPLETED
Conditions: Lung Collapse|One-Lung Ventilation|Thoracic Surgery|Video-Assisted
Interventions: DEVICE: Double lumen tube|DEVICE: Bronchial blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sertraline Hydrochloride 100 mg Tablets, Fed
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Zoloft® 100 mg Tablets|DRUG: Sertraline hydrochloride 100 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson's Disease and Tremor
Status: COMPLETED
Conditions: Parkinson's Disease|Tremor
Interventions: DEVICE: Up to 3 mA, 60 us, 130 Hz deep brain stimulation|DEVICE: Empirical unblinded deep brain stimulation programming
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transpalpebral Microcurrent Stimulation for the Improvement of Visual Acuity in Patients With Macular Degeneration
Status: COMPLETED
Conditions: Age-Related Macular Degeneration|Nonexudative Age-related Macular Degeneration
Interventions: DEVICE: Active microcurrent therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy Supplements to Improve Exercise Tolerance in Metabolic Myopathies
Status: COMPLETED
Conditions: Glycogen Storage Disease Type III
Interventions: DIETARY_SUPPLEMENT: FAXE Kondi|DIETARY_SUPPLEMENT: Faxe Kondi Free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infections|Hypercholesterolemia|Hypertriglyceridemia|Diabetes Mellitus
Interventions: DRUG: Niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Frequency & Duration of Task Practice During Constraint Induced Movement Therapy
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: Standard physiotherapy neuro-rehabilitation|OTHER: Repetition-CIMT|OTHER: Hour-CIMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Problem Solving Education and Neonatal Intensive Care Unit (NICU) Mothers
Status: COMPLETED
Conditions: Maternal Depression
Interventions: BEHAVIORAL: Problem Solving Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Aging Frailty
Status: RECRUITING
Conditions: Frailty
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arabic Gum-Absorption Study
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: menaquinone-7 from casein capsules|DIETARY_SUPPLEMENT: menaquinone-7 from arabic gum capsules|DIETARY_SUPPLEMENT: menaquinone-7 from linseed oil capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Blood Levels of Ceftriaxone Given by Suppository or Injection.
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: A. Ceftriaxone (Roche ®) 500mg (slow intravenous injection)|DRUG: B. Ceftriaxone rectal dosage form test formulation 1 (1 x 500mg)|DRUG: C. Ceftriaxone rectal dosage form test formulation 2 (1 x 500mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Crohn Disease|Ulcerative Colitis
Interventions: DRUG: 2'-Fucosyllactose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine And Rituximab (BR) in FIT Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without DEL (17P) or TP53 Mutation
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia (CLL)
Interventions: DRUG: Obinutuzumab|DRUG: Venetoclax|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Rituximab|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of Systolic Rise Time of the Plantar Arch on the Risk of Major Adverse Limb Events (MALE) and Major Adverse Cardiovascular Events (MACE) in Peripheral Artery Disease (PAD) at Critical Ischaemia Stage
Status: RECRUITING
Conditions: Major Adverse Limb Events|Major Adverse Cardiovascular Events|Peripheral Artery Disease|Critical Limb Ischemia|Hemodynamic Measure
Interventions: PROCEDURE: hemodynamic measure of the Systolic Time Rise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cognitive Behavioral Therapy for African Americans With Uncontrolled Type-2 Diabetes
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Group-based Cognitive Behavioral Intervention|BEHAVIORAL: Web-based Cognitive Behavioral Intervention|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Effect of Topical Menthol on Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Menthol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Exercise and Fall Prevention Boot Camp for Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: High intensity exercise and balance training|OTHER: Usual care arm exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0330 Erlotinib in Treating Patients With Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumor
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: erlotinib hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery
Status: UNKNOWN
Conditions: Shock, Septic|Hyperlactatemia|Oliguria|Aortic Aneurysm, Abdominal|Aortic Aneurysm, Ruptured|Aortic Stenosis
Interventions: DRUG: Fluid challenge
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Accuracy, Yield and Clinical Impact of a Low-Cost HRME in the Early Diagnosis of Esophageal Adenocarcinoma
Status: UNKNOWN
Conditions: Barrett's Esophagus
Interventions: DRUG: Proflavine, high resolution imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Physical Activity and Cardiovascular Profile of Pre-conceptional Women at Risk for GHD
Status: RECRUITING
Conditions: Gestational Hypertension|Cardiovascular Pregnancy Complication
Interventions: OTHER: supervised infrared exercise group|OTHER: supervised non-infrared exercise group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Implant-prosthetic Rehabilitation Performed With Two Implants With Different Surface Characteristics
Status: COMPLETED
Conditions: Missing Teeth|Edentulous Jaw|Edentulous Mouth
Interventions: PROCEDURE: implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Platform of Serious Games for Cognitive Intervention
Status: RECRUITING
Conditions: Mild Cognitive Impairment|Dementia|Alzheimer Disease|Aging
Interventions: DEVICE: VibrantMinds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: An Open Label Phase II Study of Indisulam in Combination With Irinotecan in Patients With Metastatic Colorectal Cancer Who Have Been Previously Treated With 5-Fluorouracil/Leucovorin and Oxaliplatin
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: E7070
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of BMS-908662 Alone or in Combination With Cetuximab in Subjects With K-RAS or B-RAF Mutation Positive Advanced or Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: BMS-908662|DRUG: BMS-908662|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Laser-Assisted Indocyanine Green Dye Angiography to Predict Mastectomy Skin Flap Viability
Status: UNKNOWN
Conditions: Breast Cancer|Breast Reconstruction|Mastectomy
Interventions: DEVICE: Laser-Assisted ICG Dye Angiography (SPY System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events
Status: RECRUITING
Conditions: Cardiovascular Primary Prevention Strategy
Interventions: COMBINATION_PRODUCT: Coronary Artery Calcium Screening and Statin Treatment|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An 18-month Prospective Natural History Study to Gain Insight Into FSHD2 Pathophysiology and Disease Progression
Status: RECRUITING
Conditions: Facioscapulohumeral Muscular Dystrophy Type 2
Interventions: DIAGNOSTIC_TEST: Validation of new COMs for FSHD2 patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy
Status: RECRUITING
Conditions: Thyroid Neoplasms|Thyroid Diseases|Hypoparathyroidism|Endocrine System Diseases|Endocrine Gland Neoplasms|Neoplasms by Site|Neoplasms|Head and Neck Neoplasms|Parathyroid Diseases
Interventions: DEVICE: PTeye
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of SHR2554 in Patients With Relapsed or Refractory Follicular Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: SHR2554
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203
Status: COMPLETED
Conditions: Hypogonadism|Low Testosterone
Interventions: DRUG: Androxal (enclomiphene citrate)|DRUG: Testim (topical testosterone)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity
Status: RECRUITING
Conditions: Acute Cardiotoxicity
Interventions: DRUG: levosemindan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Shi-style Cervical Manipulations for Cervical Radiculopathy
Status: UNKNOWN
Conditions: Cervical Radiculopathy
Interventions: OTHER: Shi-style cervical manipulations|OTHER: Cervical Traction control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation
Status: COMPLETED
Conditions: Optic, Atrophy, Hereditary, Leber
Interventions: BIOLOGICAL: GS010|DEVICE: Sham Intravitreal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IM Injections of PLX-PAD for the Regeneration of Injured Gluteal Musculature After Total Hip Arthroplasty
Status: COMPLETED
Conditions: Total Hip Arthroplasty|Muscle Injury
Interventions: BIOLOGICAL: 150M PLX-PAD|BIOLOGICAL: 300M PLX-PAD|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)
Status: COMPLETED
Conditions: Substance Use|HIV Infections|HCV Infection|Sexually Transmitted Infections (Not HIV or Hepatitis)|Overdose, Drug|Opioid Use
Interventions: BEHAVIORAL: Health Linkage|BEHAVIORAL: Overdose Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Clinical Study for Transanal Double Purse-string Rectal Anastomosis Preformed With KOL Stapler
Status: UNKNOWN
Conditions: Rectal Neoplasms
Interventions: DEVICE: KOL|DEVICE: traditional staple
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Ketamine and eCBT Intervention for PTSD
Status: UNKNOWN
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: Ketamine|BEHAVIORAL: Online Trauma-Focused Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacodynamic/Pharmacokinetic Study of Aleglitazar in Patients With Type 2 Diabetes Mellitus on Treatment With Lisinopril
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: aleglitazar|DRUG: lisinopril|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Performance of 2WIN Photoscreener With Corneal Reflex Compared to School Bus Retinoscopy by AAPOS Guidelines
Status: COMPLETED
Conditions: Refractive Errors|Amblyopia|Strabismus|Development Delay
Interventions: DEVICE: 2WIN photoscreener
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Reliability of the Determination of MisMatch Repair Deficiency Status by Endoscopic Biopsies in Oesophagus and Gastric Adenocarcinoma.
Status: NOT_YET_RECRUITING
Conditions: Gastro-oesophageal Adenocarcinoma
Interventions: DEVICE: Order of forceps : First standard biopsy forceps and second large capacity biopsy forceps|DEVICE: Order of forceps : First large capacity biopsy forceps and second standard biopsy forceps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Choices About Genetic Testing And Learning Your Risk With Smart Technology
Status: RECRUITING
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer|Breast Cancer|Pancreas Cancer|Colorectal Cancer|Endometrial Cancer|Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Relational Agent|OTHER: Clinical Letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
Status: COMPLETED
Conditions: Oesophageal Atresia|Congenital Diaphragmatic Hernia|Intestinal Atresia|Gastroschisis|Exomphalos|Anorectal Malformation|Hirschsprung Disease
Interventions: OTHER: Comparisons will be made between LMICs and HICs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p