pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Peripheral VA-ECMO Flow Variations on the Pulmonary Arterial Occlusion Pressure (PAPO) in Patients With Refractory Cardiogenic Shock.
Status: RECRUITING
Conditions: Cardiogenic Shock
Interventions: OTHER: ECMO-Flow variations
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Ano-perineal Fistulas Resistant to Surgical Treatment With a Gel and Plug of Wharton's Jelly
Status: RECRUITING
Conditions: Anal Fistula
Interventions: BIOLOGICAL: SygeLIX-F + SygeLIX-G
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alvocidib in Treating Patients With Metastatic or Unresectable Refractory Solid Tumors or Hematologic Malignancies
Status: TERMINATED
Conditions: Hematopoietic/Lymphoid Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvocidib|OTHER: pharmacological study|RADIATION: fludeoxyglucose F 18|OTHER: fluorine F 18 fluorothymidine|PROCEDURE: positron emission tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Modulatory Profiles in Massage for Individuals With Neck Pain
Status: COMPLETED
Conditions: Musculoskeletal Pain|Neck Pain
Interventions: OTHER: Pain Inducing Massage|OTHER: Light Touch Massage|OTHER: Coldpressor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of the GORE® EXCLUDER® Conformable AAA Endoprosthesis in the Treatment of Abdominal Aortic Aneurysms
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Aneurysm, Abdominal
Interventions: DEVICE: GORE® EXCLUDER® Conformable AAA Endoprosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Haploidentical Bone Marrow Transplant for Patients With Hematologic Malignancies
Status: SUSPENDED
Conditions: Hematologic Malignancies
Interventions: DRUG: Cyclophosphamide 50 mg/kg IV Days 3 and 4 post transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reactogenicity, Safety and Immunogenicity of an Universal Influenza Vaccine Uniflu
Status: UNKNOWN
Conditions: Safety Issues
Interventions: BIOLOGICAL: LD Universal Influenza Vaccine Uniflu|BIOLOGICAL: HD Universal Influenza Vaccine Uniflu|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of the Nocturnal Passy Muir Valve and Impact on Sleep Quality at an LTACH Setting
Status: COMPLETED
Conditions: Tracheostomy
Interventions: DEVICE: Passy Muir Valve|DEVICE: Tracheostomy Plug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Actonel for the Prevention of Bone Loss
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: Actonel (Risedronate)|DIETARY_SUPPLEMENT: Calcium|DIETARY_SUPPLEMENT: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization With a Gamma Camera of the Individualized Patient Dosimetry in Radioiodine Therapy of Thyroid Diseases
Status: RECRUITING
Conditions: Hyperthyroidism
Interventions: DEVICE: Additional acquisitions with the investigational gamma-camera " MoTI ".
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Silver Nitrate Versus Topical Steroid For Umbilical Granuloma
Status: COMPLETED
Conditions: Umbilical Granuloma
Interventions: DRUG: Clobetasol Propionate .05 Mg in 100 mL TOPICAL LOTION|DRUG: Silver Nitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Comparing Standard Anastomosis Closure Technique to Standard Closure Technique Plus Sylys® Surgical Sealant
Status: TERMINATED
Conditions: Colorectal and Ileorectal Anastomosis
Interventions: DEVICE: Test- Treatment with Sylys Surgical Sealan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Open Label Phase I/Randomised,Double Blind Phase II Study in mCRPC of AZD5363 In Combination With DP Chemotherapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Placebo|DRUG: AZD5363
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AT-752 in Healthy Subjects in a Dengue Human Challenge Model
Status: TERMINATED
Conditions: Dengue
Interventions: DRUG: AT-752|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant Therapy
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Breast Cancer
Interventions: DRUG: Entinostat|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma
Status: COMPLETED
Conditions: Colorectal Carcinoma|CRC
Interventions: BIOLOGICAL: JX-594|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Gastric Carcinomatosis. Phase II Randomized Study
Status: SUSPENDED
Conditions: Gastric Adenocarcinoma|Cancer Metastatic|Chemotherapy Effect
Interventions: DRUG: Pressurized intraperitoneal aerosol chemotherapy (PIPAC)|DRUG: Standard chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Investigate Therapeutic Vaccine (RUTI) Against Tuberculosis (TB)
Status: ACTIVE_NOT_RECRUITING
Conditions: Tuberculosis, Pulmonary
Interventions: BIOLOGICAL: RUTI®|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Re-TACE Versus SABR for Post-prior-TACE Incompletely Regressed HCC: a Randomized Controlled Trial (TASABR)
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma(HCC)
Interventions: RADIATION: Stereotactic ablative radiotherapy (SABR)|PROCEDURE: Re-Transcatheter arterial chemoembolization (re-TACE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of the Japanese Encephalitis Vaccine IC51 (IXIARO®, JESPECT®) in a Pediatric Population in Non-endemic Countries
Status: COMPLETED
Conditions: Encephalitis
Interventions: BIOLOGICAL: IC51|BIOLOGICAL: IC51|BIOLOGICAL: IC51
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Digital Confocal Microscopy for Real-time Diagnosis of Pancreatic Solid Lesion
Status: COMPLETED
Conditions: Pancreas Adenocarcinoma|Endoscopic Ultrasound|Digital Pathology
Interventions: PROCEDURE: Endoscopic ultrasound fine needle biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: POLE-END REAL LIFE: Endometrial Cancer Early Stages I-II and Advanced Stages III and IV Evaluation of POLE as a Prognostic Factor. Participants Are Women >= 18 Years Old, With the Pole Mutation
Status: ENROLLING_BY_INVITATION
Conditions: Endometrial Neoplasms
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia
Status: RECRUITING
Conditions: Hyperalgesia
Interventions: DRUG: Remifentanil|DRUG: Remifentanil+ Placebo|DRUG: Remifentanil +ultra-low dose naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Salvage Therapeutic Radiation With Enzalutamide and ADT in Men With Recurrent Prostate Cancer (STREAM)
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: enzalutamide|DRUG: Androgen Deprivation|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Glucose Monitoring, Contingency Management, and Motivational Interviewing for Patients With Type 2 Diabetes in Kansas City
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Behavioral Intervention with financial rewards and coaching|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: As Needed Versus Regular Intranasal Corticosteroid in Children With Perennial Allergic Rhinitis
Status: RECRUITING
Conditions: Perennial Allergic Rhinitis|Child, Only
Interventions: DRUG: Intranasal Drug (INCS = Fluticasone furoate nasal spray, Placebo = Normal saline nasal spray)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Linearity and Comparative Bioavailability of Treprostinil Diethanolamine
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Treprostinil diethanolamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Patient-Controlled TEAS vs Sham TEAS for Improve Quality of Life in Patients With Cancer Pain
Status: NOT_YET_RECRUITING
Conditions: Cancer Pain
Interventions: OTHER: Transcutaneous electrical acupoint stimulation|OTHER: sham Transcutaneous electrical acupoint stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke
Status: COMPLETED
Conditions: Atrial Fibrillation|Atrial Flutter
Interventions: OTHER: Zio®XT Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rate or Rhythm Control in CRT: the RHYTHMIC Study
Status: RECRUITING
Conditions: Atrial Fibrillation|Heart Failure
Interventions: PROCEDURE: AF catheter ablation|PROCEDURE: AV node ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resistance Training, Detraining, and Retraining Study 2024 (TraDeRe2024)
Status: RECRUITING
Conditions: Hypertrophy|Exercise Training|Skeletal Muscle Atrophy|Healthy
Interventions: OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of T-817MA in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: T-817MA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of High Frequency Chest Wall Oscillation Vests on Spirometry Measurements
Status: COMPLETED
Conditions: Cystic Fibrosis|Bronchiectasis
Interventions: DEVICE: International Biophysics AffloVest|DEVICE: Hill-Rom The Vest|DEVICE: Respirtech inCourage|DEVICE: Electromed SmartVest
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conditioned Open-label Placebos to Facilitate Opioid Reduction in Patients With Chronic Non-cancer Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Non-cancer Pain
Interventions: OTHER: P-Dragees blue Lichtenstein, Placebo dragees|OTHER: Control group (EM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Live Attenuated Varicella Vaccine in Healthy Population Aged ≥13 Years Old
Status: ENROLLING_BY_INVITATION
Conditions: Varicella
Interventions: BIOLOGICAL: Live attenuated varicella vaccines manufactured by Sinovac (Dalian) Vaccine Technology Co., Ltd|BIOLOGICAL: Live attenuated varicella vaccines manufactured by Changchun BCHT Biotechnology Co.,Ltd|BIOLOGICAL: Live attenuated varicella vaccines manufactured by Sinovac (Dalian) Vaccine Technology Co., Ltd|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Antidepressants in Chronic Back Pain
Status: COMPLETED
Conditions: Back Pain
Interventions: BEHAVIORAL: cognitive behavioral therapy|DRUG: desipramine hydrochloride|BEHAVIORAL: cognitive behavioral therapy|DRUG: benztropine mesylate 0.125 mg daily|DRUG: desipramine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Post Operative Nausea and Vomiting
Interventions: DIETARY_SUPPLEMENT: administration of ondanstron and screening of genomic DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Short-Term Mindfulness-Based Training For Major Depression Disorder: An Eye-Tracking Study
Status: UNKNOWN
Conditions: MDD
Interventions: BEHAVIORAL: Mindfulness-Based Training|BEHAVIORAL: Relaxation Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery
Status: RECRUITING
Conditions: Hemodynamics|Postoperative Recovery|Anesthesia
Interventions: DRUG: propofol|DRUG: ciprofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PENG Block vs Fascia Iliaca Block for Emergency Department Analgesia in Hip Fractures
Status: UNKNOWN
Conditions: Hip Fractures
Interventions: OTHER: Pericapsular nerve Group Block|OTHER: Infrainguinal Fascia Iliaca Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Losartan in Treating Pulmonary Fibrosis in Patients With Stage I, II, or III Non-Small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Dyspnea|Lung Cancer|Pulmonary Complications|Radiation Fibrosis
Interventions: DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dissemination and Implementation of a Web-based Relationship Safety App, myPlanKenya, for Women at Risk for Intimate Partner Violence in Nairobi, Kenya
Status: RECRUITING
Conditions: Violence, Domestic|Violence, Sexual|Violence, Gender-Based
Interventions: BEHAVIORAL: Personalized safety planning tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study Comparing ZD6474 in Combination With Pemetrexed and Pemetrexed Alone in 2nd Line NSCLC Patients
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: Vandetanib|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Fallopian Tube Carcinoma|Advanced Malignant Solid Neoplasm|Advanced Melanoma|Advanced Ovarian Carcinoma|Advanced Primary Peritoneal Carcinoma|Advanced Synovial Sarcoma|Clinical Stage III Cutaneous Melanoma AJCC v8|Clinical Stage IV Cutaneous Melanoma AJCC v8|Metastatic Fallopian Tube Carcinoma|Metastatic Melanoma|Metastatic Ovarian Carcinoma|Metastatic Primary Peritoneal Carcinoma|Metastatic Synovial Sarcoma|Pathologic Stage III Cutaneous Melanoma AJCC v8|Pathologic Stage IIIA Cutaneous Melanoma AJCC v8|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8|Pathologic Stage IV Cutaneous Melanoma AJCC v8|Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Stage III Fallopian Tube Cancer AJCC v8|Stage III Ovarian Cancer AJCC v8|Stage III Primary Peritoneal Cancer AJCC v8|Stage IIIA Fallopian Tube Cancer AJCC v8|Stage IIIA Ovarian Cancer AJCC v8|Stage IIIA Primary Peritoneal Cancer AJCC v8|Stage IIIA1 Fallopian Tube Cancer AJCC v8|Stage IIIA1 Ovarian Cancer AJCC v8|Stage IIIA2 Fallopian Tube Cancer AJCC v8|Stage IIIA2 Ovarian Cancer AJCC v8|Stage IIIB Fallopian Tube Cancer AJCC v8|Stage IIIB Ovarian Cancer AJCC v8|Stage IIIB Primary Peritoneal Cancer AJCC v8|Stage IIIC Fallopian Tube Cancer AJCC v8|Stage IIIC Ovarian Cancer AJCC v8|Stage IIIC Primary Peritoneal Cancer AJCC v8|Stage IV Fallopian Tube Cancer AJCC v8|Stage IV Ovarian Cancer AJCC v8|Stage IV Primary Peritoneal Cancer AJCC v8|Stage IVA Fallopian Tube Cancer AJCC v8|Stage IVA Ovarian Cancer AJCC v8|Stage IVA Primary Peritoneal Cancer AJCC v8|Stage IVB Fallopian Tube Cancer AJCC v8|Stage IVB Ovarian Cancer AJCC v8|Stage IVB Primary Peritoneal Cancer AJCC v8|Unresectable Melanoma|Unresectable Ovarian Carcinoma|Unresectable Synovial Sarcoma
Interventions: DRUG: Cyclophosphamide|DRUG: Decitabine|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Leukapheresis|BIOLOGICAL: TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shortening Treatment by Advancing Novel Drugs
Status: COMPLETED
Conditions: Tuberculosis, Pulmonary, Drug Sensitive|Tuberculosis, Pulmonary, Multi Drug-resistant
Interventions: DRUG: Moxifloxacin|DRUG: PA-824|DRUG: Pyrazinamide|DRUG: HRZE (Rifampicin, Isoniazid, Pyrazinamide, Ethambutol combination)|DRUG: HR (rifampicin plus isoniazid combination tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study of Topically Applied I-020201 as an Adjunct to Good Standard-of-care in Patients With Chronic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: PROCEDURE: Good Standard of Care (GSoC)|BIOLOGICAL: Vehicle|BIOLOGICAL: I-020201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Metronomic Capecitabine With Camrelizumab for Treatment of Refractory Solid Tumor Trial (Cohort 1)
Status: UNKNOWN
Conditions: Advanced Cervical Cancer
Interventions: DRUG: Capecitabine, camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-human (FIH), Multicenter, Open-Label, Phase I Study of PTX-912 in Patients With Locally Advanced/Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced Cancer|Solid Tumor|Metastatic Cancer
Interventions: DRUG: PTX-912
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-vivo Transmission Model in Semi-immune Adults
Status: NOT_YET_RECRUITING
Conditions: Controlled Human Malaria Infection|Induced Blood Stage Malaria Infection|Malaria Transmission|Malaria Challenge
Interventions: DRUG: Piperaquine tablets , which will be administered orally as a single dose of 480mg (320mg+160mg).|DRUG: Doxycycline (100mg tablets strength as Doxycycline Hyclate) will also be administered orally and will be given as 1 tablet (100mg) Once daily for 7 days.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma
Interventions: RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy|RADIATION: photon beam radiation therapy|RADIATION: intensity-modulated radiation therapy|RADIATION: proton beam radiation therapy|DRUG: temozolomide|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Dietary Management in Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Standardized|BEHAVIORAL: Usual Care Control (UCC)|BEHAVIORAL: Personalized Guidance to Minimize Postprandial Glycemic Response (PPGR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: Abicipar Pegol|DRUG: Ranibizumab|OTHER: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Smart! Effectiveness of a Smartphone Use Intervention on Students' Performance and Well-being
Status: UNKNOWN
Conditions: Experimental Group: Smartphone Use Reduction|Control Group
Interventions: BEHAVIORAL: Smartphone Use Reduction in Academic Context|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignancies That Harbor IDHR132 Mutations
Interventions: DRUG: IDH305
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Mesenchymal Stem Cell Transplantation in Decompensated Liver Cirrhosis
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: PROCEDURE: mesenchymal stem cell transplantation via peripheral vein|OTHER: mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Glimepiride Compared With Sitagliptin as an add-on Therapy to Metformin in Severe Insulin Deficiency Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Severe Insulin Deficient Diabetes
Interventions: DRUG: Glimepiride|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strength Training in Children With Spastic Diplegic and Hemiplegic Cerebral Palsy Receiving Botulinum Toxin
Status: UNKNOWN
Conditions: Spastic Diplegic Cerebral Palsy|Hemiplegic Cerebral Palsy
Interventions: OTHER: Strength training|COMBINATION_PRODUCT: Strength training with botulinum toxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Immunogenicity of Simultaneous Administration of Quadrivalent Influenza Vaccine and 23-valent Pneumococcal Vaccine
Status: COMPLETED
Conditions: Pneumococcal Pneumonia|Influenza
Interventions: BIOLOGICAL: Simultaneous administration of Pneumovax NP® and Fluvic HA syringe®|BIOLOGICAL: Sequential administration of Pneumovax NP® and Fluvic HA syringe®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of a New Topical Natural Health Product for the Treatment of Herpes Labialis
Status: UNKNOWN
Conditions: Herpes Labialis
Interventions: OTHER: BOR15001L7|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Study to Evaluate a Risk-adapted Strategy for Treatment of Extra Cranial Non Seminomateous Malignant Germ Cell Tumour in Children and Adolescent
Status: COMPLETED
Conditions: Extra Cranial Non Seminomateous Malignant Germ Cell Tumour
Interventions: DRUG: Velbe-Bleomycin-Cisplatin|DRUG: Vepeside-ifosfamide-Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diadynamic and Exercises in Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Group that received aplication of Diadynamic currents associated to Exercise during eight weeks with three sessions a week|OTHER: Group that received exercise during eight weeks with three sessions a week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Amino Acid Kinetics in Blood After Consuming Different Milk Protein Supplements
Status: COMPLETED
Conditions: Healthy Participants
Interventions: OTHER: Strength Training|DIETARY_SUPPLEMENT: Milk 1%|DIETARY_SUPPLEMENT: Whey protein concentrate 80 (WPC-80)|DIETARY_SUPPLEMENT: Microparticulated whey|DIETARY_SUPPLEMENT: Hydrolyzed whey|DIETARY_SUPPLEMENT: Native whey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Acute Leukemia in Remission|Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Acute Myeloid Leukemia With FLT3/ITD Mutation|Acute Myeloid Leukemia With Gene Mutations|Aplastic Anemia|B-Cell Non-Hodgkin Lymphoma|CD40 Ligand Deficiency|Chronic Granulomatous Disease|Chronic Leukemia in Remission|Chronic Lymphocytic Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Myelomonocytic Leukemia|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Congenital Amegakaryocytic Thrombocytopenia|Congenital Neutropenia|Congenital Pure Red Cell Aplasia|Glanzmann Thrombasthenia|Immunodeficiency Syndrome|Myelodysplastic Syndrome|Myelofibrosis|Myeloproliferative Neoplasm|Paroxysmal Nocturnal Hemoglobinuria|Plasma Cell Myeloma|Polycythemia Vera|Recurrent Non-Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma|Secondary Acute Myeloid Leukemia|Secondary Myelodysplastic Syndrome|Severe Aplastic Anemia|Shwachman-Diamond Syndrome|Sickle Cell Disease|T-Cell Non-Hodgkin Lymphoma|Thalassemia|Waldenstrom Macroglobulinemia|Wiskott-Aldrich Syndrome
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Peripheral Blood Stem Cell Transplantation|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of PeptiSleep in Healthy Males and Females With Mild to Moderate Sleep Impairment
Status: RECRUITING
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: PeptiSleep|DIETARY_SUPPLEMENT: Placebo MCC micro-crystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia
Status: COMPLETED
Conditions: Ventilator-acquired Pneumonia
Interventions: DEVICE: EVAC-PU-ETT|DEVICE: PVC-ETT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation
Status: RECRUITING
Conditions: Cardiac Allograft Vasculopathy
Interventions: DIAGNOSTIC_TEST: ICA|DIAGNOSTIC_TEST: PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: G56W1 in Women With Postmenopausal Osteoporosis
Status: UNKNOWN
Conditions: Postmenopausal Osteoporosis
Interventions: BIOLOGICAL: rhPTH（1-34） 28.2μg|BIOLOGICAL: rhPTH（1-34） 56.5μg|BIOLOGICAL: teriparatide acetate(Teribone™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, PK of GC2129A in Healthy Volunteers Under Fed Conditions
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: GC2129A(Period 1)|DRUG: Linaglptin 5mg and Metformin Hydrocholoride 1000mg(Period 1)|DRUG: GC2129A(Period 2)|DRUG: Linaglptin 5mg and Metformin Hydrochloride 1000mg(Period 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FTD-TPI, Bevacizumab, and Radioembolization With 166Ho-microspheres in Refractory Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Systemic treatment (FTD-TPI and bevacizumab)|DEVICE: Radioembolization with 166-Ho microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-mullerian Hormone,Testesterone,Esrtadiol,Testesterone/Esrtadiol Ratio as Predictive Values for TESA and TESE Outcome in Non Obstructive Azoospermia
Status: UNKNOWN
Conditions: Non-obstructive Azoospermia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiation Therapy Followed by Carmustine in Treating Patients Who Have Supratentorial Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carmustine|RADIATION: radiation therapy|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer
Status: WITHDRAWN
Conditions: Paralytic Ileus
Interventions: BEHAVIORAL: Gum chewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Long-term Extension Study of PCI-32765 (Ibrutinib)
Status: ENROLLING_BY_INVITATION
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Mantle Cell Lymphoma|Follicular Lymphoma|Diffuse Large B-cell Lymphoma|Waldenstrom Macroglobulinemia|Chronic Graft Versus Host Disease
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Antibiotic Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Placebo|DRUG: Amoxicillin and clavulanic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Human Mass Balance Study to Determine the Total Recovery of Radioactivity in Urine and Faeces Following a Single Oral Dose of 14C Radiolabelled ONO-4053
Status: COMPLETED
Conditions: Healthy Adult Male Subjects
Interventions: DRUG: [14C]ONO-4053
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Different Oxygen Concentration on Postoperative Pulmonary Complications After Pulmonary Reexpansion
Status: RECRUITING
Conditions: Pulmonary Disease
Interventions: PROCEDURE: low FiO2|PROCEDURE: high FiO2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of Probiotics to Evaluate Colonization With Antimicrobial Resistant Bacteria
Status: COMPLETED
Conditions: Infectious Disease of Digestive Tract
Interventions: DIETARY_SUPPLEMENT: Lactobacillus rhamnosus GG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing.
Status: COMPLETED
Conditions: Hypoxia, Altitude
Interventions: DEVICE: continuous-flow portable oxygen concentrator (cPOC)|DEVICE: pulsed-flow portable oxygen concentrator (pPOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Removal of Intracanal Medication on Post Operative Pain
Status: UNKNOWN
Conditions: Effects of the Elements
Interventions: DEVICE: Calcium hydroxide with XP-endo Finisher file|DEVICE: Calcium hydroxide with Irrisafe Ultrasonic tip|DEVICE: Calcium hydroxide with side vented needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness Study of CBT for Anxiety in Children
Status: COMPLETED
Conditions: Separation Anxiety Disorder|Social Anxiety Disorder|Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive behavioural therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rosuvastatin in Order to Induce Preeclampsia Resolution in Severe PET up to 48 Hours Following Delivery
Status: UNKNOWN
Conditions: Severe Pre-eclampsia
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel, Pembrolizumab and Olaparib in Previously Treated Advanced Gastric Adenocarcinoma
Status: RECRUITING
Conditions: Advanced Gastric Adenocarcinoma
Interventions: DRUG: Paclitaxel|DRUG: Olaparib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunosuppressant Combined With Pirfenidone in CTD-ILD
Status: ACTIVE_NOT_RECRUITING
Conditions: Pirfenidone|Connective Tissue Diseases|Interstitial Lung Disease
Interventions: DRUG: Pirfenidone|DRUG: DMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin Impact on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery
Status: UNKNOWN
Conditions: Coronary Artery Bypass Grafting|Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Melatonin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: RO7507062|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caries Cognition and Identification in Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Secondary Caries
Interventions: PROCEDURE: Dental treatment|PROCEDURE: Dental treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis
Status: COMPLETED
Conditions: Calcaneal Apophysitis|Sever's Disease
Interventions: OTHER: Podoactiva cutom-made foot orthoses|OTHER: Podoactiva heel lifts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care
Status: RECRUITING
Conditions: Sedation Complication|Mechanical Ventilation in Neonates
Interventions: OTHER: Dose-effect relationship of morphine +/- midazolam administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Evaluation of a Psychoeducation Program in Individuals Diagnosed With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Psychoeducation Program|BEHAVIORAL: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hairy Cell Leukemia
Interventions: DRUG: Pentostatin|DRUG: Rituximab|DRUG: Bendamustine|DRUG: Acetaminophen|DRUG: Diphenhydramine|DRUG: Epinephrine|DRUG: Antihistamines|DRUG: Corticosteroids|DRUG: Bronchodilators|OTHER: Intravenous (IV) Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Pertuzumab (in Combination With Trastuzumab and Docetaxel) in Indian Participants With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Non-operative Management of SBO Without Nasogastric Tube Placement
Status: WITHDRAWN
Conditions: Small Bowel Obstruction
Interventions: PROCEDURE: Nasogastric tube placement|PROCEDURE: No Nasogastric tube use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Immunogenicity, Safety and Reactogenicity of a Booster Dose of Various COVID-19 Vaccine Platforms in Individuals Primed With Several Regimes.
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: SCB-2019/Clover|BIOLOGICAL: AstraZeneca/Fiocruz|BIOLOGICAL: Pfizer/Wyeth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of Colchicine in Patients With Myocardial Infarction
Status: WITHDRAWN
Conditions: Myocardium; Injury|Myocardial Infarction|Myocardial Ischemia
Interventions: DRUG: Colchicine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis
Status: RECRUITING
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Cationorm Pro|DEVICE: Vismed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Glucose-Lowering Efficacy of MK-0893 in Participants With Type 2 Diabetes Mellitus (MK-0893-005)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MK-0893|DRUG: Metformin|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of TAK-058 and Ondansetron on P50 Auditory Gating in Participants With Stable Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: TAK-058|DRUG: Ondansetron|DRUG: TAK-058 Placebo|DRUG: Ondansetron Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: FMISO-based Adaptive Radiotherapy for Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Cancer|Hypoxia|FMISO|Dose Escalation
Interventions: RADIATION: Dose escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients
Status: UNKNOWN
Conditions: Gingivitis|Periodontal Inflammation|Orthodontic Appliance Complication
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri Prodentis®-lozenges (DSM 17938, ATCC PTA 5289)|DIETARY_SUPPLEMENT: Placebo-lozenges (BioGaia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Crossover RCT of TAMER Lenses in Myopia Control
Status: RECRUITING
Conditions: Myopia|Progressive
Interventions: DEVICE: TAMER Lens Spectacle|DEVICE: SV lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Hyaluronan" Formulation for Type 2 Diabetic Patients With Dry Mouth
Status: COMPLETED
Conditions: Dry Mouth|Xerostomia|Type 2 Diabetics
Interventions: DEVICE: HA formulation Oral Spray|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Celecoxib Versus Placebo Before and After Knee Surgery on the Overall Use of Analgesics After Surgery
Status: COMPLETED
Conditions: Arthroscopy
Interventions: DRUG: Celecoxib|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive|Chronic Heart Failure|Depression
Interventions: DRUG: Sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study Comparing Placebo and ASP3652 in the Treatment of Women With Bladder Pain Syndrome / Interstitial Cystitis (BPS/IC)
Status: COMPLETED
Conditions: Cystitis, Interstitial|Urinary Bladder Disease|Pain|Urologic Diseases
Interventions: DRUG: ASP3652|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Seoul National University Airway Registry
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Asthma|Asthma With Chronic Obstructive Pulmonary Disease|Bronchiectasis|Inactive Tuberculosis of Lung|Chronic Obstructive Airway Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nitric Oxide Mediated Vasodilatory Response to Hawthorn Standardized Extract
Status: COMPLETED
Conditions: Prehypertension|Mild Hypertension
Interventions: DIETARY_SUPPLEMENT: Hawthorn|DIETARY_SUPPLEMENT: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Efficacy and Safety of Saxagliptin VS. Glimepiride in Chinese T2DM Patients Controlled Inadequately With Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Saxagliptin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT