pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pathophysiological Study of CSA in Adults With pLVEF
Status: TERMINATED
Conditions: Central Sleep Apnea
Interventions: OTHER: Critical airway closure pressure (Pcrit) measurment|OTHER: Acoustic pharyngometry|OTHER: High density surface electroencephalogram neural mapping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Composite Steep-pulseTreatment Device Used in Patients With Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DEVICE: Composite Steep-pulse Treatment Device|DRUG: Tamsulosin Hydrochloride Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aprepitant Effects on Oxycodone Response
Status: COMPLETED
Conditions: Narcotic Abuse
Interventions: DRUG: Aprepitant 0mg|DRUG: Aprepitant 40mg|DRUG: Aprepitant 200mg|DRUG: Oxycodone 0mg, p.o.|DRUG: Oxycodone 20mg, p.o.|DRUG: Oxycodone 40mg, p.o.|DRUG: Oxycodone 0mg, IN|DRUG: Oxycodone 15mg, IN|DRUG: Oxycodone 30mg, IN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Open Label Study to Evaluate the Tolerability and Safety of Enteric-coated Mycophenolate Sodium (EC-MPS) in Combination With Cyclosporine Microemulsion (CsA-ME) in Maintenance Renal Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplant Recipients
Interventions: DRUG: Enteric-coated Mycophenolate sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A New Delineation Approach for Oral Cavity, Oropharynx, Larynx and Hypopharynx in IMRT for Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer|Radiotherapy|Oropharynx Abnormality|Radiotherapy; Adverse Effect
Interventions: RADIATION: "Oropharyngeal mucosa"|RADIATION: oropharynx|RADIATION: oropharynx and "oropharyngeal mucosa"
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Contrast Enhanced Spectral Mammography for the Evaluation of Pathologic Nipple Discharge
Status: RECRUITING
Conditions: Breast Carcinoma
Interventions: PROCEDURE: Contrast Enhanced Digital Mammography|PROCEDURE: Digital Tomosynthesis Mammography|DRUG: Iodinated Contrast Agent|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: paclitaxel|DRUG: topotecan hydrochloride|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Dance-therapy and Chronic Pain
Status: NOT_YET_RECRUITING
Conditions: Chronic Pain|Complex Regional Pain Syndromes|Tension-Type Headache
Interventions: BEHAVIORAL: Dance-therapy|BEHAVIORAL: Art-therapy|BEHAVIORAL: Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Efficacy and Safety of ASKP1240 in de Novo Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: ASKP1240|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil (MMF)|DRUG: Basiliximab|DRUG: Methylprednisone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Repeated-Dose Evaluation of a Pain Relieving Drug Use and Safety of OROS Hydromorphone HCI in Patients With Chronic Non-Malignant Pain
Status: COMPLETED
Conditions: Pain|Analgesics|Opioid
Interventions: DRUG: OROS Hydromorphone HCI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Group Interpersonal Psychotherapy for Depressed Adolescents in School-based Clinics
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Group interpersonal psychotherapy for depressed adolescents (IPT-AG)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Bracing for People With Type I Modic Changes
Status: TERMINATED
Conditions: Low Back Pain|Bone Marrow Edema|Brace|Modic Changes|Magnetic Resonance Imaging
Interventions: DEVICE: Horizon 627 Lumbar Brace, Aspen Medical Company, Oak Canyon, Irvine, CA 92618
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluocinolone Acetonide Insert (ILUVIEN®) for Diabetic Macular Edema (FAD) Study
Status: WITHDRAWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: ILUVIEN®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osimertinib and Etoposide as First-Line Treatment in Osimertinib-Resistant Advanced EGFR-Mutant NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|EGFR Gene Mutation|Non Small Cell Lung Cancer Stage IIIB|Non-small Cell Lung Cancer Stage IV
Interventions: DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness Study of rhGAA in Patients With Advanced Late-Onset Pompe Disease Receiving Respiratory Support
Status: COMPLETED
Conditions: Pompe Disease (Late-onset)|Glycogen Storage Disease Type II (GSD-II)|Acid Maltase Deficiency Disease|Glycogenosis 2
Interventions: BIOLOGICAL: Myozyme
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Canadian Hemophilia Prophylaxis Study
Status: COMPLETED
Conditions: Severe Hemophilia A
Interventions: BIOLOGICAL: Recombinant Factor VIII (Advate/Helixate FS/KoegenateFS)|BIOLOGICAL: Recombinant Factor VIII (Advate/Helixate FS/KoegenateFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
Status: RECRUITING
Conditions: Colonic Neoplasms
Interventions: BEHAVIORAL: Aerobic exercise|BEHAVIORAL: Progressive stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II)
Status: RECRUITING
Conditions: Stroke, Ischemic
Interventions: DRUG: Tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Reconstruction|Quadriceps Muscle Weakness|Transcranial Direct Current Stimulation
Interventions: DEVICE: Anodal transcranial direct current stimulation (tDCS) - Soterix Medical Inc, 1x1 tDCS (conventional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.
Status: COMPLETED
Conditions: Incretin Action|Obesity
Interventions: OTHER: GLP-1 infusion|OTHER: Glucagon infusion|OTHER: Oxyntomodulin infusion|OTHER: GLP-1 and glucagon infusion|OTHER: Placebo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Brazil Nut Supplementation in Patients With Chronic Kidney Disease Undergoing Conservative Treatment
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases|Chronic Kidney Disease stage3|Chronic Kidney Disease Stage 3A|Chronic Kidney Disease Stage 3B|Chronic Kidney Disease stage4|Inflammation|Inflammatory Response|Oxidative Stress|Intestinal Microbiota
Interventions: DIETARY_SUPPLEMENT: Brazil Nut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Utility of the Use of N-acetylcysteine Associated With Conventional Treatment in Patients With Severe Acute Alcoholic Hepatitis (Maddrey> 32)
Status: UNKNOWN
Conditions: Alcoholic Hepatitis
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IO102/IO103, Nivolumab, and Relatlimab in People With Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: IO102/IO103|DRUG: Nivolumab-Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUX-Dx TRENDS Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System.
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: Investigational LUX-Dx ICM Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Uterine Anatomical Flexion Degree ( Uterocervical Angle) and Intrauterine Device (IUD) Dislocation
Status: COMPLETED
Conditions: Contraception|Intrauterine Device Dislocation
Interventions: OTHER: measuring uterocervical angle and uterine dimensions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Comparing The Efficacy, Safety And Tolerability Of Latanoprost 75, 100 And 125 ug/ml To Xalatan In The Treatment Of Primary Open-Angle Glaucoma And Ocular Hypertension
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: latanoprost 75 ug|DRUG: latanoprost 100 ug|DRUG: latanoprost 125 ug|DRUG: latanoprost 50 ug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds
Status: COMPLETED
Conditions: Facial Wrinkles
Interventions: DEVICE: CosmetaLife|DEVICE: Restylane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of YUMI Uterine Manipulator
Status: COMPLETED
Conditions: Gynecologic Condition|Scheduled for a Total Laparoscopic or Robotic-assisted Hysterectomy
Interventions: PROCEDURE: YUMI manipulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body, How it Moves Into, Through and Out of the Body When Single and Multiple Amounts Are Taken as Tablets in Japanese Healthy Male Participants
Status: COMPLETED
Conditions: Chronic Kidney Disease|Healthy Volunteers
Interventions: DRUG: BAY3283142|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
Status: COMPLETED
Conditions: Neisseria Gonorrhoeae Infection|Chlamydia Trachomatis Infection
Interventions: DRUG: Ceftriaxone 1000mg + doxycycline 100 mg|DRUG: Cefixime 800mg + doxycycline 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Adalimumab or Placebo in Patients With Mild to Moderate COVID-19 (COMBAAT)
Status: WITHDRAWN
Conditions: Mild to Moderate COVID-19
Interventions: DRUG: Adalimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of Active Venous Thrombus With Positron Emission Tomography (PET)
Status: RECRUITING
Conditions: Venous Thromboembolism (VTE)
Interventions: OTHER: Additional blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Muscle Stretching and Neural Mobilizations on Lower Limbs Range of Motion in Asymptomatic Subjects.
Status: COMPLETED
Conditions: Asymptomatic Condition
Interventions: OTHER: muscle streching exercice|OTHER: Slider|OTHER: Tensioner
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Efficacy of DFPP in Patients With AAGN
Status: TERMINATED
Conditions: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Interventions: OTHER: DFPP&CTX|DRUG: CTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Disorder Related to Bone Marrow Transplantation|Leukemia|Transplantation Infection
Interventions: DRUG: Fludarabine|DRUG: Clofarabine|DRUG: Busulfan|DRUG: Thymoglobulin|PROCEDURE: Stem Cell Infusion|DRUG: Tacrolimus|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Mucosal Biofilm Formations in Adenoidectomy Specimens
Status: COMPLETED
Conditions: Chronic Serous Otitis Media, Simple or Unspecified
Interventions: PROCEDURE: With chronic middle ear effusion|PROCEDURE: Without chronic middle ear effusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Pemetrexed and Carboplatin/Cisplatin or Gemcitabine and Carboplatin/Cisplatin With or Without IMC-1121B in Participants Previously Untreated With Recurrent or Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: IMC-1121B (ramucirumab)|DRUG: Pemetrexed|DRUG: Carboplatin (AUC 6)|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Carboplatin (AUC 5)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring and Managing Glucose Levels in People With Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Cancer|PDAC - Pancreatic Ductal Adenocarcinoma|Hyperglycemia
Interventions: PROCEDURE: Endocrinologist-directed target blood glucose level 4-10 mmol/L using data from a continuous glucose monitor (CGM)|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ON 123300 (Narazaciclib) and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapsed and/or Refractory Multiple Myeloma
Interventions: DRUG: ON 123300|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Pro-Inflammatory Cytokines and Bone Metabolism Mediators Around Laser-Lok and Machined Transmucosal Abutments
Status: COMPLETED
Conditions: Dental Implants
Interventions: DEVICE: Laser-Lok|DEVICE: Machined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease and Elevated hsCRP
Status: RECRUITING
Conditions: Coronary Heart Disease
Interventions: DRUG: DFV890|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biodistribution and Dosimetry of Ga-68 P16-093 in Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer Recurrent|Prostate Cancer
Interventions: DRUG: Ga-68 P16-093 PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pulsed-Field-Ablation to Treat Atrial fiBRillation With a novEl multimodalIty Generator
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: PFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Durvalumab and Tremelimumab in Combination With Either Y-90 SIRT or DEB-TACE for Intermediate Stage HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable|HCC
Interventions: DRUG: Tremelimumab|DRUG: Durvalumab|PROCEDURE: Y-90 SIRT|PROCEDURE: DEB-TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Citrus Extract on Exercise Performance in Moderately Trained Athletes
Status: COMPLETED
Conditions: Exercise Performance
Interventions: DIETARY_SUPPLEMENT: citrus extract|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.
Status: UNKNOWN
Conditions: Chronic Periodontitis|Periodontal Bone Loss
Interventions: DRUG: Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML|DRUG: Enamel Matrix Proteins (Active comparator group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Growth and Weight Gain in ELBW Infants Fed an Exclusively Human Milk Based Diet With Prolacta®
Status: COMPLETED
Conditions: Weight Gain|Human Milk|Preterm Infants|Extremely Low Birth Weight
Interventions: DIETARY_SUPPLEMENT: Human milk fortifier based on human milk (Prolacta)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Pilates and Myofascial Release on Women's Chronic Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: self-myofascial release combined reformer Pilates|OTHER: Reformer Pilates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Maternal Outcomes Following Manual Lysis of the Placenta.
Status: SUSPENDED
Conditions: Third Stage of Delivery
Interventions: PROCEDURE: Manual Lysis of Placenta after 15 minutes (Intervention)|PROCEDURE: Manual Lysis of Placenta after 30 minutes (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Equivalence of Triferic® (Ferric Pyrophosphate Citrate) Administered Via Hemodialysate and Intravenously to Adult CKD-5HD Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Triferic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Transcutaneous Electrical Stimulation on Constipation
Status: COMPLETED
Conditions: Cerebral Palsy|Constipation
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation(TENS)|OTHER: Baseline Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Evaluation of Triple Therapy With Vonoprazan, Amoxicillin and Bismuth for Eradication of Helicobacter Pylori
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Vonoprazan|DRUG: Amoxicillin|DRUG: Esomeprazole|DRUG: Amoxicillin|DRUG: Clarithromycin|DRUG: Bismuth potassium citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Benefits of a 6-month Brisk Walking Program in Sedentary Postmenopausal Women
Status: COMPLETED
Conditions: Sedentary Lifestyle|Postmenopausal Women
Interventions: OTHER: Brisk walking program|OTHER: physical activity habit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Docetaxel Versus Abiraterone as First-line Treatment in mCRPC Patients With Intraductal Carcinoma of the Prostate
Status: UNKNOWN
Conditions: Prostate Cancer|Castration-resistant Prostate Cancer|Drug
Interventions: DRUG: Abiraterone Acetate|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting
Status: ENROLLING_BY_INVITATION
Conditions: Coronary Artery Disease|Ischemic Heart Disease
Interventions: DEVICE: Philips SyncVision system with Philips pressure wires|PROCEDURE: standard of care angiographically-guided PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Honey Dressing - A Preventive Procedure for Post-Surgical Site Infection.
Status: COMPLETED
Conditions: Wound Infection|Wound Dehiscence|Wound Bleeding|Wound Surgical
Interventions: BIOLOGICAL: Honey Dressing|DRUG: Iodine Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: MD1003 100mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS Combined With rTMS for Negative Symptoms of Schizophrenia
Status: ENROLLING_BY_INVITATION
Conditions: Schizophrenia Negative Type
Interventions: DEVICE: tDCS active stimulation combined with rTMS sham stimulation|DEVICE: rTMS active stimulation combined with tDCS sham stimulation|DEVICE: tDCS active stimulation combined with rTMS active stimulation|DEVICE: tDCS sham stimulation combined with rTMS sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Survival Rate of Dental Implants Placed in Sinus Lift Performed With Two Different Grafts
Status: COMPLETED
Conditions: Dental Implant Survival Rate
Interventions: DEVICE: Survival rate dental implant (OsseoSpeed™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium and Decreased Kidney Function
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter|Urethral Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ridge Preservation After Tooth Extraction Using Cortical Versus Cancellous Freeze Dried Bone Allograft
Status: COMPLETED
Conditions: Tooth Extraction
Interventions: DEVICE: cortical FDBA|DEVICE: Cancellous FDBA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia
Status: COMPLETED
Conditions: Community-acquired Pneumonia|Sepsis|Inflammatory Response|Mortality|Biomarkers|SIRS
Interventions: DRUG: Tablets|DRUG: Clarithromycin 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular Imaging of HER2 Expression in HER2-positive Breast Cancer Using 99mTc-ADAPT6 vs 99mTc-DARPinG3
Status: COMPLETED
Conditions: Breast Cancer Female
Interventions: DRUG: 99mTc-ADAPT6|DRUG: 99mTc-DARPinG3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diet Selection Pre-Colonoscopy: Comparison Between Clear, Low-residue and Regular Diet
Status: COMPLETED
Conditions: Bowel Preparation Quality
Interventions: OTHER: Regular diet|OTHER: Clear fluid diet|OTHER: Low residue diet|DIAGNOSTIC_TEST: Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Comparative Study of Bispectral Index (BIS) Values Obtained From Standard Frontal Position and Alternative Infra-orbital Position During Total Intravenous Anaesthesia (TIVA).
Status: COMPLETED
Conditions: Intraoperative Awareness
Interventions: DEVICE: Bispectral index
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Point of Care Optic Nerve Sheath Ultrasound to Assess Intracranial Pressure
Status: COMPLETED
Conditions: Optic Nerve Sheath|Hypertonic Saline
Interventions: DRUG: intermittent boluses of Hypertonic saline|DRUG: continuous infusion of Hypertonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multi-omics Studies of Host-microbiome Interaction in Chronic Obstructive Pulmonary Disease and Bronchiectasis
Status: NOT_YET_RECRUITING
Conditions: COPD Exacerbation|Bronchiectasis With Acute Exacerbation
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Single Dose of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD)
Status: RECRUITING
Conditions: Lumbar Disc Disease
Interventions: BIOLOGICAL: BRTX-100|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas
Status: RECRUITING
Conditions: Ewing Sarcomas|Chondrosarcomas|Osteosarcomas|Chondroma|CIC-Rearranged Sarcoma
Interventions: DRUG: Regorafenib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Weight Bearing for Unstable Ankle Fractures Undergoing Operative Stabilization
Status: COMPLETED
Conditions: Ankle Fracture
Interventions: PROCEDURE: Early Weight bearing + Cam Boot|PROCEDURE: Non-Weight Bearing + Cam Boot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Outcomes in Patients Taking Fluticasone Propionate/Salmeterol Combination or Other Inhaled Corticosteroids
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone propionate/salmeterol combination|DRUG: Inhaled corticosteroids
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
Status: RECRUITING
Conditions: Open tíbia Fracture
Interventions: DRUG: Antibiotic Cement Bead Pouch|DEVICE: Negative Pressure Wound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Education to Decrease in Sodium Intake Evaluated With 24 Hour Urinary Sodium Excretion (RCT)
Status: COMPLETED
Conditions: Hypertension|Overweight or Obesity|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Education group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: alvocidib|DRUG: mitoxantrone hydrochloride|DRUG: carboplatin|DRUG: cytarabine|DRUG: sirolimus|DRUG: etoposide|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Program on Preterm Infants' Sleep, and Caregiver's Sleep, Stress, Quality of Life, and Attachment
Status: UNKNOWN
Conditions: Preterm Infants|Sleep|Quality of Life
Interventions: BEHAVIORAL: Early Sleep Facilitation Program|OTHER: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Tolerability and Pharmacokinetics of BI 653048 H3PO4 Oral Drinking Solution in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 653048 H3PO4 solution|DRUG: BI 653048 H3PO4 low dose capsule|DRUG: BI 653048 H3PO4 high dose capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Study of NKTR-214 in Combination With Nivolumab in Patients With Metastatic and/or Locally Advanced Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: SARCOMA
Interventions: DRUG: NKTR-214|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Cell Regeneration Therapy With Mesenchymal Stem Cells From Adipose Tissue in Critical Chronic Ischemic Syndrome of Lower Limbs (CLI) in Nondiabetic Patients.
Status: COMPLETED
Conditions: Critical Limb Ischemia
Interventions: OTHER: Mesenchymal stem cells from adipose tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irrigation and Suction Trial to Prevent SSI
Status: COMPLETED
Conditions: Surgical Site Infection|Diabete Mellitus|Abdominal Hysterectomy
Interventions: DEVICE: Irrigation and suction through subcutaneus drains
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Early Palliative Care Integration on Patients With Newly Diagnosed Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: OTHER: Palliative Care|OTHER: FACT-MM questionnaire|OTHER: HADS questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
Status: RECRUITING
Conditions: Miscarriage|Frozen Embryo Transfer|Natural Cycle|Hormone Replacement Therapy Cycle|Preimplantation Genetic Screening|Euploid Embryos
Interventions: DRUG: Estradiol Valerate|DRUG: Micronized progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Casodex|DRUG: Eulexin|DRUG: LHRH agonist|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Hypopnea|OSA|OSAH
Interventions: DEVICE: Provent Professional Sleep Apnea Therapy Device|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Of Effects of MRP Vs NDT For Balance and Gait in Chronic Ischemic Stroke Patients RCT
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DIAGNOSTIC_TEST: Motor Relearning Program (MRP)|DIAGNOSTIC_TEST: Neuro Development Treatment (NDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pain on Injection of Propofol: a Comparison of Lidocaine and Alkalinized Lidocaine
Status: COMPLETED
Conditions: Pain on Injection of Propofol,Lidocaine, Alkalinized Lidocaine
Interventions: DRUG: alkalinized lidocaine|DRUG: Lidocaine|DRUG: Placebo (for alcalinized lidocaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study on Ca Blocker Versus AII Antagonists in Hypertension With Type 2 Diabetes
Status: UNKNOWN
Conditions: Hypertension|Diabetes Mellitus, Type 2
Interventions: DRUG: Angiotensin II receptor antagonists, Calcium channel blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Celecoxib and Pregabalin Compared With Celecoxib Monotherapy, in Patients With Chronic Low Back Pain Having a Neuropathic Component
Status: TERMINATED
Conditions: Chronic Low Back Pain With a Neuropathic Component
Interventions: DRUG: pregabalin and celecoxib|DRUG: Placebo and celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The PRECISE Protocol: Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: cCTA with selective FFRct
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sunitinib, Tamoxifen, and Cisplatin in Treating Patients With High-Risk Ocular Melanoma
Status: UNKNOWN
Conditions: Intraocular Melanoma
Interventions: DRUG: cisplatin|DRUG: sunitinib malate|DRUG: tamoxifen citrate|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Emergency Pulpotomy Versus Pulp Extirpation on Anesthetic Efficacy in Endodontic Treatment of Acute Pulpitis
Status: UNKNOWN
Conditions: Symptomatic Irreversible Pulpits
Interventions: OTHER: emergency pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|AML, Adult
Interventions: DRUG: evorpacept|DRUG: venetoclax|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Stem Cell Transplantation for Progressive Systemic Sclerosis
Status: COMPLETED
Conditions: Scleroderma|Cardiac Involvement|Autologous Stem Cell Transplantation
Interventions: DRUG: Autologous stemcell transplantation with CD (cluster of differentiation) 34 selected stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EBUS-Miniprobes Sampling for Peripheral Lung Lesions
Status: TERMINATED
Conditions: Lung Cancer|Peripheral Pulmonary Lesions
Interventions: PROCEDURE: trans bronchial biopsy guided by echo-endoscopic miniprobes|PROCEDURE: if first one negative: samples under fluoroscopic control
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Kahn Study; Investigation Of The Efficacy Of Ziprasidone Versus Olanzapine In The Management Of Recent-Onset Psychosis; A Flexible-Dose, Parallel Group, Double-Blind Study
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: olanzapine|DRUG: ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Long-term Effects of Arabinoxylans on Intestinal Barrier Function
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: DIETARY_SUPPLEMENT: NAXUS|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability & Efficacy of MSDC-0602K in Patients With NASH
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease|Non-alcoholic Steatohepatitis|NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: MSDC-0602K|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Antitumor Activity Study of Loncastuximab Tesirine and Durvalumab in Diffuse Large B-Cell, Mantle Cell, or Follicular Lymphoma
Status: TERMINATED
Conditions: Diffuse Large B-Cell Lymphoma|Mantle Cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: Loncastuximab Tesirine and Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Let's STOP Now Trial: Smoking in Trauma Orthopaedic Patients
Status: COMPLETED
Conditions: Smoking, Tobacco|Fractures, Bone
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Motivational Interviewing + Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Adjuvant Chemotherapy in Patients With Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer|Adjuvant Chemotherapy
Interventions: DRUG: adjuvant chemotherapy with 5-FU isolated|DRUG: adjuvant chemotherapy with 5-FU associated with oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy
Status: UNKNOWN
Conditions: Thyroid Associated Opthalmopathies
Interventions: DRUG: Prednisone+placebo of Doxycycline|DRUG: Doxycycline+placebo of Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 11C-Acetate PET/CT Imaging As a Biomarker of Amyloid-Induced Neuroinflammation
Status: TERMINATED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: 11C-acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections
Status: COMPLETED
Conditions: Disseminated Intravascular Coagulation|Critical Illness|Sars-CoV2|Viral Infection|Coagulation Disorder, Blood|Covid19
Interventions: DIAGNOSTIC_TEST: Thrombin Generation Assay (TGA)|DIAGNOSTIC_TEST: Thrombomodulin Modified Thrombin Generation Assay (TGA-TM)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuroimaging Effects of Cognitive Behavioral Therapy in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Disease Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: PROCEDURE: Therapeutic Hypothermia|OTHER: Therapeutic Normothermia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ATX Register Accolade Stem & Trident/Tritanium Cup With X3 Insert
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthroplasty, Replacement, Hip
Interventions: DEVICE: Accolade stem|DEVICE: Accolade II stem|DEVICE: Trident/Tritanium cup
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD
Status: RECRUITING
Conditions: PTSD|Relational Problems
Interventions: DRUG: 3,4-methylenedioxymethamphetamine (MDMA)|BEHAVIORAL: Brief Cognitive Behavioral Conjoint Therapy (bCBCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Oral BAY85-8501 in Patients With Non-CF (Cystic Fibrosis) Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: DRUG: BAY85-8501|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Viziatek ISL™ Refractive Phakic Intra Sulcus Lens for Refraction Adjustment in Blind Volunteers
Status: TERMINATED
Conditions: Myopia
Interventions: DEVICE: Viziatek ISL™ (hereinafter referred to as the "ISL") implanted in blind eye.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ketorolac Versus Opioid for Pain After Endoscopy
Status: COMPLETED
Conditions: Kidney Calculi|Ureteral Calculi
Interventions: DRUG: Oxycodone|DRUG: Ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP) to Prevent Infection and Delayed Wound Healing
Status: COMPLETED
Conditions: Elective Foot and Ankle Surgery.
Interventions: BIOLOGICAL: PRP and PPP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Suvorexant on Post-operative Sleep Disturbance
Status: RECRUITING
Conditions: Postoperative Insomnia|Postoperative Delirium
Interventions: DRUG: Suvorexant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Kilohertz-frequency and Low-frequency Current on Triceps Surae
Status: RECRUITING
Conditions: Healthy
Interventions: OTHER: Russian current 10%|OTHER: Aussie current 10%|OTHER: Pulsed current 500 µs phase|OTHER: Pulsed current 200 µs phase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bryostatin 1 Plus Gemcitabine in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bryostatin 1|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Filipino Multicomponent Intervention to Maintain Cognitive Performance in High Risk Population (FINOMAIN)
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: INDAK (Improving Neurocognition through Dance and Kinesthetics)|BEHAVIORAL: Nutrition Counseling|BEHAVIORAL: Standardized Vascular Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION