pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Kinetics of Microparticles Under Chemotherapy in Patients With Gastric or Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer|Gastric Cancer
Interventions: PROCEDURE: kinetics of microparticles under chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect Of Preoperative Chemotherapy On Short-Term Outcome After Pancreatic Resection
Status: COMPLETED
Conditions: Locally Advanced Pancreatic Adenocarcinoma
Interventions: PROCEDURE: Pancreatic resection after preoperative chemotherapy|PROCEDURE: Pancreatic resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study for the Foldax Tria Aortic Heart Valve
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Valve Disease|Aortic Valve Stenosis
Interventions: DEVICE: Foldax Tria Aortic Valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFFICACY AND TOLERABILITY OF BECLOMETHASONE DIPROPIONATE 100 µg + FORMOTEROL 6 µg pMDI VIA HFA-134a vs. FLUTICASONE 125 µg + SALMETEROL 25 µg pMDI
Status: COMPLETED
Conditions: Bronchial Asthma
Interventions: DRUG: beclomethasone dipropionate plus formoterol fumarate combination|DRUG: fluticasone propionate plus salmeterol xinafoate combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Effectiveness of Stryker Surpass Evolve™ Flow Diverter System
Status: ACTIVE_NOT_RECRUITING
Conditions: Aneurysm, Intracranial
Interventions: DEVICE: Surpass Evolve Flow Diverter System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade
Status: COMPLETED
Conditions: Underdosing of Unspecified General Anesthetics
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project
Status: RECRUITING
Conditions: Undifferentiated Round Cell Sarcoma
Interventions: OTHER: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Screening for Lung Cancer in Older Patients (PLCO Screening Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Carcinoma
Interventions: OTHER: Screening Questionnaire Administration|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Study to Investigate the Interaction of GSK1292263 With Rosuvastatin and Simvastatin in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Simvastatin|DRUG: Rosuvastatin|DRUG: GSK1292263
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Self Stretching, Plantar Self Massage and Manual Stimulation on Balance and Reaction Time
Status: UNKNOWN
Conditions: Healthy|Stretch
Interventions: OTHER: static stretching|OTHER: self massage|OTHER: Manual Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: An Extension of Istradefylline in Parkinson's Disease Patients Who Have Completed Studies 6002-EU-007, 6002-US-013 or 6002-US-018
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Istradefylline ( KW-6002)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SUBLIVAC FIX Birch Dose Tolerability/Dose Range Finding
Status: COMPLETED
Conditions: Allergic Rhinitis|Allergic Rhinoconjunctivitis
Interventions: DRUG: SUBLIVAC FIX Birch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXTEND (Eltrombopag Extended Dosing Study)
Status: COMPLETED
Conditions: Purpura, Thrombocytopaenic, Idiopathic
Interventions: DRUG: eltrombopag olamine (SB-497115-GR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobility Assessment in Multi-morbidity
Status: NOT_YET_RECRUITING
Conditions: Arthritis|Asthma|Atrial Fibrillation|Bronchiectasis|Cancer|Chronic Kidney Diseases|Chronic Obstructive Pulmonary Disease|Coronary Heart Disease|Anxiety|Depression|Diabetes Mellitus|Heart Failure|Hypertension|Osteoporosis|Parkinson Disease|Peripheral Vascular Disease|Stroke|Transient Ischemic Attack
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Travatan and Cosopt in Primary Open-Angle Glaucoma or Ocular Hypertension
Status: TERMINATED
Conditions: Open-angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Travatan|DRUG: Cosopt|DRUG: Placebo (Timolol Vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thyroxine Replacement Therapy After Lobectomy for Low-risk Papillary Thyroid Carcinoma
Status: RECRUITING
Conditions: Thyroid Cancer|Surgery|Recurrence
Interventions: DRUG: Thyroxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Evaluate Long-Term Safety of Subcutaneous (SC) Tocilizumab in Participants With Giant Cell Arteritis (GCA)
Status: COMPLETED
Conditions: Giant Cell Arteritis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Spironolactone on Pain in Older People With Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GOLimumab and Methotrexate Versus Methotrexate in Very Early PsA (GOLMEPsA)
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Golimumab|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Carbidopa/Levodopa/Entacapone in Patients With Parkinson's Disease Requiring Initiation of Levodopa Therapy
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Carbidopa/levodopa/entacapone|DRUG: Immediate release carbidopa/levodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: 18F-PSMA-1007 PET/CT Imaging in Patients With Biochemically Recurrent or High-risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: 18F-PSMA-1007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Dose Escalation Study of the Safety and Pharmacokinetics of ME-143 Single Agent for Refractory Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: ME-143
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in Treating Patients With an Advanced Solid Tumor or Lymphoma
Status: COMPLETED
Conditions: Lymphoma|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: alvespimycin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Acceptance and Commitment Therapy (ACT) for Combating the Effects of Race-Related Stress Among Black Adolescents
Status: RECRUITING
Conditions: Race-related Stress|Depression, Anxiety|Quality of Life|Stress Reaction
Interventions: BEHAVIORAL: ACT for Race Related Stress
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein Source on Plasma Amino Acid Concentrations
Status: COMPLETED
Conditions: Protein Deposition
Interventions: OTHER: Pork|OTHER: Egg|OTHER: Black beans|OTHER: Almonds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Microbiome Immunotherapy Toxicity and Response Evaluation
Status: RECRUITING
Conditions: Melanoma|Renal Cancer|Lung Cancer
Interventions: DRUG: Nivolumab|DRUG: Pembrolizumab|DRUG: Ipilimumab|DRUG: Durvalumab|DRUG: Tremelimumab|DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of MCLA-129 Combined With Befotertinib in the Treatment of Advanced Non-small Cell Lung Cancer With EGFR Sensitive Mutation
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer、EGFR Sensitive Mutation
Interventions: DRUG: MCLA-129: 1500mg or 2000mg IV Q2W|DRUG: Befotertinib: 75 mg or 100 mg Po QD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of an Innovative Air Mattress On Critically Ill Infants
Status: RECRUITING
Conditions: Skin Abnormalities|Skin; Injury, Superficial|Skin; Ulcer, Decubitus
Interventions: DEVICE: Exposure of the patient to a novel air mattress.|DEVICE: Exposure of the patient to a conventional foam mattress.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Immune Response and Safety of a Seasonal Virus-Like Particle Influenza Vaccine in Healthy Young Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Novavax Quadrivalent vaccine|BIOLOGICAL: Novavax Quadrivalent vaccine|BIOLOGICAL: Novavax Quadrivalent vaccine|BIOLOGICAL: Novavax Trivalent vaccine|BIOLOGICAL: cTIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diagnostic Accuracy of Ultrasonography and Computed Tomography in the Diagnosis of Mild-moderate Acute Diverticulitis
Status: COMPLETED
Conditions: Acute Diverticulitis
Interventions: DIAGNOSTIC_TEST: Abdominal Ultrasonography|DIAGNOSTIC_TEST: Abdominal Computerized Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Acute Post-Radiation Hyperbaric Oxygen (HBO2) for Breast Cancer Patients Who Have Recently Completed Radiation Therapy
Status: TERMINATED
Conditions: Breast Cancer
Interventions: PROCEDURE: Hyperbaric Oxygen Therapy|DRUG: Trental Pill|DIETARY_SUPPLEMENT: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A New Monitor to Measure Dermal Blood Flow in Critically Ill Patients: a Preliminary Study
Status: COMPLETED
Conditions: Positive-Pressure Respiration, Intrinsic|Critically Ill Patients
Interventions: OTHER: Dermal blood flow measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis
Status: RECRUITING
Conditions: Stroke, Acute|Biological Specimen Banks|Biomarkers|Etiology|Prognosis
Interventions: OTHER: Collection of thrombus that is responsible for stroke and blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: mOm Incubator Pilot Study
Status: COMPLETED
Conditions: Hypothermia
Interventions: DEVICE: mOm incubator|DEVICE: standard incubator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: BTI320 (SUGARDOWN®) on Post-Prandial Hyperglycaemia in Subjects With Pre-Diabetes
Status: COMPLETED
Conditions: Pre-Diabetes
Interventions: DRUG: BTI320|DRUG: BTI320 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane Versus Propofol for Intubation in Neonatal Intensive Care
Status: UNKNOWN
Conditions: Endotracheal Intubation
Interventions: DRUG: Administration of sevoflurane|DRUG: Administration of propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-DXd in the First-Line Treatment of Locally Advanced or Metastatic TNBC-LAR HER2-low Patients
Status: NOT_YET_RECRUITING
Conditions: Triple-Negative Breast Cancer
Interventions: DRUG: Trastuzumab Deruxtecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cell-derived Pleiotropic Factor in Treating Non-healing Wounds
Status: UNKNOWN
Conditions: Mesenchymal Stem Cell-derived Bioactivator for Treating Chronic Wounds
Interventions: BIOLOGICAL: Stem cell-derived derived pleiotropic factor|BIOLOGICAL: fibroblast growth factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Intrathecal Enzyme Replacement Therapy for MPS I
Status: TERMINATED
Conditions: Spinal Cord Compression|Mucopolysaccharidosis I|Hurler-Scheie Syndrome|Scheie Syndrome|Lysosomal Storage Disease
Interventions: DRUG: laronidase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunphenon Epigallocatechin-gallate (EGCg) in Relapsing-remitting Multiple Sclerosis (SuniMS Study)
Status: COMPLETED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: DRUG: epigallocatechin-gallate (Sunphenon)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of LY450139 on the Long Term Progression of Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: LY450139|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Trial on Alleviation of Infant Malnutrition With Fortified Spread or Maize-soy Flour Food Supplements
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: No food supplement|DIETARY_SUPPLEMENT: Food supplement: fortified spread|DIETARY_SUPPLEMENT: Food supplement: maize-soy flour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Rising Single-doses of BIA 6-512 and Their Effect on the Levodopa Pharmacokinetics
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Placebo oral capsule|DRUG: Sinemet® 100/25|DRUG: Comtan®|DRUG: BIA 6-512 25 mg|DRUG: BIA 6-512 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EXPLORE: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005
Status: TERMINATED
Conditions: Dry Age-related Macular Degeneration
Interventions: DRUG: GT005; Low Dose|DRUG: GT005; High Dose|DRUG: GT005; Low Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Frozen Shoulder (Scapular Mobilization Versus Scapular PNF)
Status: ENROLLING_BY_INVITATION
Conditions: Frozen Shoulder|Scapular Mobilization|Scapular Proprioceptive Neuromuscular Facilitation
Interventions: OTHER: Group A SCAPULAR MOBILIZATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Carbamazepine on the Pharmacokinetics of RO4917523 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Carbamazepine|DRUG: RO4917523
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Comparing Intramyometrial Tranexamic Acid and Oxytocin for Blood Loss in Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Cesarean Section Complications|Tranexamic Acid|Oxytocin|Post Partum Hemorrhage
Interventions: DRUG: Tranexamic acid injection|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Double-Blind, Placebo-Controlled, Dose Ranging Study of Xanamem® in Healthy Elderly Volunteers
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Alzheimer's Disease
Interventions: DRUG: Xanamem® 5 mg|DRUG: Placebo|DRUG: Xanamem® 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality
Status: COMPLETED
Conditions: Heart Failure|Dilated Cardiomyopathy|Reduced LVEF
Interventions: DEVICE: ICD|OTHER: Optimal medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of YKP3089 in Subjects With Treatment Resistant Partial Onset Seizures
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: YKP3089|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ED50 and ED95 of Isobaric Bupivacaine for Post-Partum Bilateral Tubal Ligation
Status: COMPLETED
Conditions: Anesthesia, Local
Interventions: OTHER: Dose adjustment of bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Objective and Subjective Outcomes of a Trifocal IOL in Eyes With Different AL
Status: COMPLETED
Conditions: Cataract|Presbyopia|Lenses, Intraocular|Myopia|Satisfaction
Interventions: OTHER: AT LISA tri 839MP (Carl Zeiss Meditec AG)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Extension Study of Subcutaneous Secukinumab in Patients With Juvenile Psoriatic Arthritis (JPsA) and Enthesitis Related Arthritis (ERA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Juvenile Psoriatic Arthritis|Enthesitis Related Arthritis
Interventions: DRUG: AIN457
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contrasting Dosivent With Plus Flow Vu Spacer in Bronchial Hyperreactivity Participants
Status: COMPLETED
Conditions: Bronchial Hyperreactivity|Inhalant Use
Interventions: DEVICE: Dosivent|DEVICE: Aerochamber Plus Flow Vu
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Intensity-matched Agility and Cycling Exercise Training on PD Patients' Clinical Symptoms, Posture, and Mobility
Status: COMPLETED
Conditions: Parkinson Disease|Balance|Rehabilitation|Motor Function
Interventions: OTHER: Single-blind RTC of PD patients|OTHER: cycling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load
Status: RECRUITING
Conditions: HIV-1-infection, Subtype b
Interventions: DRUG: Decitabine cycle 1|DRUG: Romidepsin cycle 1|DRUG: Decitabine cycle 2|DRUG: Romidepsin cycle 2|DRUG: Decitabine cycle 3|DRUG: Romidepsin cycle 3|DRUG: Decitabine cycle 4|DRUG: Romidepsin cycle 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Pharmacokinetics of Microdose Midazolam, Dabigatran, Pitavastatin, Atorvastatin and Rosuvastatin in Healthy Volunteers and Renal Impairment Patients
Status: RECRUITING
Conditions: Chronic Kidney Disease
Interventions: DRUG: Midazolam, dabigatran etexilate, pitavastatin, rosuvastatin and atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Balancing Kinematically Aligned Total Knee Replacements During Total Primary Knee Arthroplasty Using Verasense
Status: RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: PROCEDURE: Total Knee Arthroplasty|DEVICE: Total Knee Arthroplasty with Verasense sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lanreotide Efficacity in High Output Stoma: a Multicentric Randomized Study
Status: TERMINATED
Conditions: High Output Stoma
Interventions: DRUG: Effects of lanreotide with current anti-diarrheal treatments (diosmectite and loperamide)|DRUG: Effects of current anti-diarrheal treatments (diosmectite and loperamide) alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Emotion Regulation Interventions for Alcohol-Related Sexual Aggression
Status: COMPLETED
Conditions: Sexual Aggression|Heavy Drinking
Interventions: BEHAVIORAL: Cognitive Restructuring|BEHAVIORAL: Mindfulness|OTHER: Alcohol consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Contribution of Genetics, Non-invasive Methods and Neuropsychology in Focal Cryptogenic Epilepsies
Status: RECRUITING
Conditions: Epilepsies, Partial|Epilepsy Intractable
Interventions: DIAGNOSTIC_TEST: Standard of care|DIAGNOSTIC_TEST: Functional magnetic resonance imaging-Electroencephalogram combined analysis|DIAGNOSTIC_TEST: High density- electroencephalogram or 7 Tesla magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Human Rhinovirus Infection and Airway Remodeling Mediators
Status: TERMINATED
Conditions: Asthma
Interventions: BIOLOGICAL: GMP-grade HRV-39|PROCEDURE: Bronchoalveolar Lavage|DRUG: Methacholine Inhalation Challenge|PROCEDURE: Nasal Lavage|PROCEDURE: Nasal Scrapings|PROCEDURE: Bronchial Brushings|PROCEDURE: Lung Mucosal Biopsy|PROCEDURE: Allergen Skin Prick Testing|PROCEDURE: Venipuncture|PROCEDURE: Bronchoscopy|PROCEDURE: Spirometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Clinical Study to Evaluate a Stannous Fluoride Toothpaste for the Relief of Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: 0.454% Stannous fluoride (SnF2) and 0.072% sodium fluoride (NaF): 1450 ppm fluoride in total|OTHER: 1400 ppm fluoride as sodium monofluorophosphate (SMFP)|OTHER: Stannous Chloride (SnCl2) and 0.15% NaF: 1450 ppm fluoride in total
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: D-ALBA Frontline Sequential Dasatinib and Blinatumomab in Adult Philadelphia Positive Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Dasatinib|DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Recurrent Malignant Solid Neoplasm
Interventions: DRUG: Axitinib|DRUG: Crizotinib|DRUG: Palbociclib Isethionate|DRUG: Talazoparib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid's Effects in Patients Undergoing Laparoscopic Radical Prostatectomy
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Tranexamic acid|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: 90Yttrium Colloid for the Treatment of Cystic Sellar/Parasellar Tumors
Status: RECRUITING
Conditions: Cystic Tumors of the Sellar/Parasellar Region
Interventions: RADIATION: 90yttrium colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lot-to-lot Consistency of a Plant-Derived Quadrivalent Virus-Like Particles Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Virus Diseases|RNA Virus Infections|Respiratory Tract Infections|Respiratory Tract Disease|Influenza
Interventions: BIOLOGICAL: Quadrivalent VLP Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Vaginal Microbiome as a Biomarker for the Improvement of Vaginal Health in Women With Breast Cancer, ARISE Study
Status: RECRUITING
Conditions: Breast Neoplasms
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Electronic Health Record Review|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Tiotropium: The HELIOS Study (BY217/M2-128)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Roflumilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
Status: RECRUITING
Conditions: Myeloid Chimerism
Interventions: DEVICE: CliniMACS CD34 Reagent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RDEA3170 Tablet and Capsule Bioavailability Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RDEA3170,10 mg|DRUG: RDEA3170, 2.5 mg|DRUG: RDEA3170, 5 mg|DRUG: RDEA3170, 10 mg|DRUG: RDEA3170, 2.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase III Study of Docetaxel + S-1 vs. S-1 for Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: docetaxel + S-1|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB
Status: NOT_YET_RECRUITING
Conditions: Coronary Disease|Heart Diseases|Cardiovascular Diseases|Myocardial Ischemia|Atherosclerosis|Arterial Occlusive Diseases|Vascular Diseases|Coronary Artery Disease|Acute Coronary Syndrome|Coronary Stenosis|Molecular Mechanisms of Pharmacological Action|Enzyme Inhibitors|MTOR Inhibitors|Protein Kinase Inhibitors|Physiological Effects of Drugs|Immunosuppressive Agents|Antineoplastic Agents|High Bleeding Risk|Single Antiplatelet Therapy|Dual Antiplatelet Therapy|Cyclooxygenase Inhibitors|P2Y12 Inhibitor|Platelet Aggregation Inhibitors|Aspirin|Clopidogrel
Interventions: DEVICE: Drug-coated balloon|DRUG: Single antiplatelet therapy (SAPT)|DRUG: Dual antiplatelet therapy (DAPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Screening of Arterial Hypertension by Community Outreach Workers in the Cayenne Metropolitan Area to Reduce the Incidence of Cardiovascular Disease
Status: NOT_YET_RECRUITING
Conditions: High Blood Pressure
Interventions: DRUG: antihypertensive drug treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Accelerating Healthcare Engagement in Healthy Food Interventions - Food Rx in High Risk Pregnant Mothers With About Fresh and Texas Children's Health Plan
Status: NOT_YET_RECRUITING
Conditions: Nutrition in High-Risk Pregnancy
Interventions: BEHAVIORAL: Usual Care Fresh Connect cardholder engagement|BEHAVIORAL: Enhanced engagement communication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Genakumab for Injection in Patients With Gout Flare
Status: RECRUITING
Conditions: Acute Gout|Gout Flare
Interventions: DRUG: Genakumab for injection|DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Anti-tumor Activity of RP12146, in Patients With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor|Extensive-stage Small-cell Lung Cancer|Locally Advanced Breast Cancer|Metastatic Breast Cancer|Platinum-sensitive Ovarian Cancer|Platinum-Sensitive Fallopian Tube Carcinoma|Platinum-Sensitive Peritoneal Cancer
Interventions: DRUG: RP12146
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in Oncology
Status: RECRUITING
Conditions: Leukemia, Lymphocytic, Acute|Leukemia, Myeloid, Acute|Lymphoma|Clostridium Difficile Infection
Interventions: OTHER: Diet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Korean Red Ginseng (KRG) on Dry Mouth
Status: COMPLETED
Conditions: Xerostomia
Interventions: DIETARY_SUPPLEMENT: Korean Red Ginseng Powder Capsule|DIETARY_SUPPLEMENT: Corn-starch powder with ginseng flavor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of TOCOSOL(R) Paclitaxel as Initial Treatment for Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: TOCOSOL(R) Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
Status: RECRUITING
Conditions: Diffuse Cutaneous Systemic Sclerosis|Interstitial Lung Disease
Interventions: DRUG: Tulisokibart|DIAGNOSTIC_TEST: Companion diagnostic ( CDx)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-parameter Magnetic Resonance Imaging Guides Precise Treatment of Urothelial Carcinoma
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Chemotherapy|DIAGNOSTIC_TEST: Immediate Multiparametric MRI|PROCEDURE: Cystectomy and Lymphadenectomy|DIAGNOSTIC_TEST: conventional Multiparametric MRI|DIAGNOSTIC_TEST: Baseline Multiparametric MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Olokizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Drug Interaction Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) 100mg On The Pharmacokinetics Of Aripiprazole When Coadministered To Healthy Subjects
Status: COMPLETED
Conditions: Pharmacokinetics|Cytochrome P-450 CYP2D6|CYP3A4 Protein, Human
Interventions: DRUG: Aripiprazole|DRUG: Aripiprazole + desvenlafaxine succinate sustained release
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression
Status: COMPLETED
Conditions: Depressive Disorder, Treatment-Resistant
Interventions: DRUG: Esketamine|DRUG: Placebo|DRUG: Duloxetine (Oral Antidepressant)|DRUG: Escitalopram (Oral antidepressant)|DRUG: Sertraline (Oral Antidepressant)|DRUG: Venlafaxine Extended Release (XR) (Oral Antidepressant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis
Status: RECRUITING
Conditions: Reversal of Neuromuscular Blockade
Interventions: DRUG: Sugammadex|DRUG: Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research of Intensive Metabolic Intervention Before Pregnancy in PCOS
Status: UNKNOWN
Conditions: PCOS|Impaired Glucose Tolerance
Interventions: DRUG: Acarbose 100 MG|DRUG: Exenatide|DRUG: Orlistat|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epidermal Coverage of Traumatic Wound Injuries Via Use of Autologous Spray Skin Applied Over Bilayered Wound Matrix
Status: TERMINATED
Conditions: Wounds and Injury
Interventions: DEVICE: Recell|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Trial of LY900003 Plus Gemcitabine and Cisplatin Versus Gemcitabine and Cisplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: LY900003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Step-Up Versus Infliximab Monotherapy in Patients With Ulcerative Colitis (P05553)
Status: TERMINATED
Conditions: Colitis, Ulcerative
Interventions: BIOLOGICAL: Infliximab|DRUG: Prednisolone|DRUG: 5-aminosalicylic acid|DRUG: Azathioprine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Vibrating System for Improving Vestibular Physical Therapy
Status: TERMINATED
Conditions: Vertigo|Dizziness|Nausea|Balance
Interventions: DEVICE: Transcranial vibrating system|DEVICE: Transcranial vibrating system sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Trial of Aralast in New Onset Diabetes (RETAIN)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1
Interventions: BIOLOGICAL: Aralast NP 45 mg dose|BIOLOGICAL: Aralast NP 90 mg dose|BIOLOGICAL: Aralast NP 180 mg dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPLEMENT Study- A First in Human Study of Metabolic Neuromodulation Therapy
Status: COMPLETED
Conditions: Diabetes|Endocrine, Nutritional and Metabolic Diseases (E00-E89)
Interventions: DEVICE: Metabolic Neuromodulation System (MNS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24 Week Efficacy and 3-year Safety and Efficacy of Secukinumab in Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: Secukinumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy, Safety and Costs of Recombinant FVIII Products Between On-demand and Secondary Prophylaxis Groups in Haemophilia A Patients
Status: COMPLETED
Conditions: Hemophilia
Interventions: OTHER: Recombinant Factor VIII (Kogenate, BAY14-2222)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders
Status: COMPLETED
Conditions: Campylobacter Infections|Irritable Bowel Syndrome
Interventions: GENETIC: DNA Analysis of Blood Sample|PROCEDURE: Flexible sigmoidoscopy with colonic biopsies|PROCEDURE: Small bowel and colonic gastrointestinal permeability|DIAGNOSTIC_TEST: Stool sample analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Preemptive Analgesic Efficacy of Nefopam
Status: COMPLETED
Conditions: Breast Neoplasm
Interventions: DRUG: Nefopam|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Leukemia, Acute Myeloid (AML), Child|Lymphoma, Non-Hodgkin|Myelodysplastic Syndromes|Primary Immune Deficiency Disorder|Osteopetrosis|Cytopenia|Hemoglobinopathy in Children|Anemia, Aplastic
Interventions: BIOLOGICAL: BPX-501 T cells|DRUG: Rimiducid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder
Status: COMPLETED
Conditions: Overactive Detrusor|Neurogenic Bladder
Interventions: DRUG: Oxybutynin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment With Antipsychotics
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: GENETIC: GeneSight Psychotropic (GEN)|GENETIC: Enhanced-GeneSight Psychotropic (E-GEN)|OTHER: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Melphalan and Filgrastim to Stimulate Peripheral Stem Cells in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: BIOLOGICAL: filgrastim|DRUG: melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of Subcutaneous JS005 Injection in the Treatment of Adults With Moderate to Severe Chronic Plaque Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Moderate to Severe Chronic Plaque Psoriasis
Interventions: BIOLOGICAL: JS005 (recombinant humanized monoclonal antibody against IL-17A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Efficacy of Coronary Sinus Narrowing in Patients With Coronary Microvascular Dysfunction
Status: COMPLETED
Conditions: Coronary Microvascular Dysfunction
Interventions: DEVICE: The Neovasc Reducer™ System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV Iron Treatment of Restless Legs Syndrome
Status: WITHDRAWN
Conditions: Restless Legs Syndrome
Interventions: DRUG: Iron isomaltoside 1000|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions
Status: COMPLETED
Conditions: Primary Hypogonadism|Hypogonadotropic Hypogonadism
Interventions: DRUG: Testosterone Topical Gel, 1.62% Metered Pump|DRUG: AndroGel (testosterone gel) 1.62% Metered-Dose Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-exposure Prophylaxis / Preemptive Therapy for SARS-Coronavirus-2
Status: COMPLETED
Conditions: Corona Virus Infection|Acute Respiratory Distress Syndrome|SARS-CoV Infection|Coronavirus|Coronavirus Infections
Interventions: DRUG: Hydroxychloroquine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sucrose on Pain Relief During Venous Blood Sampling in Preterm Infants
Status: COMPLETED
Conditions: Pain
Interventions: OTHER: 0.2 ml sucrose 25%|OTHER: 0.5 ml sucrose 25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin, 300 mg|DRUG: Metformin XR, 500 mg|DRUG: CANA/MET XR FDC, Formulation 1, 150 mg/500|DRUG: CANA/MET XR FDC, Formulation 2, 150 mg/500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics and Efficacy of ARQ-151 Cream in Adults With Mild to Moderate Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: ARQ-151 cream 0.5%|DRUG: ARQ-151 cream 0.15%|DRUG: ARQ-151 vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: LDE225|DRUG: Wafarin|DRUG: Bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Topical Sodium Nitrite|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors
Status: NOT_YET_RECRUITING
Conditions: Cancer|Breast Cancer|Colorectal Cancer|Sarcoma|Lymphoma|Testicular Cancer
Interventions: BEHAVIORAL: AYA Educational Information|BEHAVIORAL: AYA STEPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Muscle Energy Techniques and Trigger Point Therapy in Asymptomatic Persons With Latent Trigger Point
Status: COMPLETED
Conditions: Asymptomatic Condition
Interventions: OTHER: Muscle Energy Technique (MET)|OTHER: Trigger Point Therapy (TPT)|OTHER: Muscle Energy Technique (MET) combined with Trigger Point Therapy (TPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION