pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy and Safety of High-dose Vitamin C Combined With Chinese Medicine Against Coronavirus Pneumonia (COVID-19)
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Alpha-interferon alpha, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste, fumigation/inhalation of vitamin C|DRUG: Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and 5% glucose|DRUG: Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and high-dose vitamin C treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability Study of Sotagliflozin as Adjunct Therapy in Adult Patients With Type 1 Diabetes Mellitus Who Have Inadequate Glycemic Control With Insulin Therapy
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Sotagliflozin|DRUG: Sotagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neutrophil-to-lymphocyte Ratio vs C-reactive Protein as Early Predictors of Anastomotic Leakage After Colorectal Surgery
Status: COMPLETED
Conditions: Anastomotic Leak
Interventions: DIAGNOSTIC_TEST: Neutrophil to Lymphocyte Ratio and C-reactive protein
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Low Dose Versus Normal Dose Ketorolac for Postoperative Pain After Prostatectomy and Hysterectomy
Status: RECRUITING
Conditions: Anesthesia|Surgery
Interventions: DRUG: 10 mg IV ketorolac|DRUG: 30 mg IV ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)"
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Ondansetron|DRUG: Dexamethasone|DRUG: Aprepitant|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Study of Gemcitabine, Sorafenib and Radiotherapy in Patients With Unresectable Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Adenocarcinoma of the Pancreas
Interventions: DRUG: Gemcitabine, Sorafenib|PROCEDURE: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2|Heart Failure, Congestive
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Fluid Responsiveness Evaluation by a Non-invasive Method in Children, Extended to PREterm Infants - FRENCH-PREMA
Status: RECRUITING
Conditions: Premature Baby 26 to 32 Weeks|Premature Baby 33 to 36 Weeks
Interventions: PROCEDURE: Non interventional study (study of diagnostic accuracy with an extra echocardiographic assessment).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid
Status: ACTIVE_NOT_RECRUITING
Conditions: Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia (CBT-I)|BEHAVIORAL: Sleep and Lifestyle Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Stoma Prehabilitation on Stoma Patients
Status: COMPLETED
Conditions: Stoma|Anxiety|Depression|Quality of Life
Interventions: BEHAVIORAL: Stoma prehabilitation|BEHAVIORAL: preoperative stoma education|BEHAVIORAL: postoperative stoma education|BEHAVIORAL: Postoperative stoma care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Two Steroid Nasal Implants Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis
Status: WITHDRAWN
Conditions: Chronic Sinusitis|Rhinosinusitis
Interventions: DEVICE: Propel 'implant'|DRUG: Triamcinolone|DEVICE: Nasopore
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency
Status: COMPLETED
Conditions: Chronic Venous Insufficiency
Interventions: DRUG: Coumarin/troxerutin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of a Tetanus Test at a Fixed Remifentanil Concentration Before Laryngoscopy and Skin Incision
Status: COMPLETED
Conditions: Intravenous Anesthetic Agent Overdose
Interventions: DRUG: Remifentanil adapted to SPI|DRUG: Remifentanil fixed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Validation of a Pediatric Pictorial Version of the QOR-15 Postoperatory Functional Recovery Scale - QoR-15 Pédiatric
Status: COMPLETED
Conditions: Surgical Intervention|Minor
Interventions: OTHER: Questionnaire Quality-of-recovery 15 (QoR-15)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial Evaluating Efficacy & Safety of RVD +/- Panobinostat in Transplant Eligible, Newly Diagnosed Multiple Myeloma (NDMM)
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Revlimid|DRUG: Velcade|DRUG: dexamethasone|DRUG: Farydak
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluoride Concentration in Inter-proximal Fluid From Dental Sealants
Status: COMPLETED
Conditions: Caries
Interventions: OTHER: Sealant application|OTHER: sealant application|OTHER: sealant application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pictou County PEP: A 6-Month, Home-Based, Personal Empowerment Program for Adults With a Chronic Medical Condition Living in Pictou County
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Condition
Interventions: BEHAVIORAL: Pictou County Person Empowerment Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Enzyme-containing Mouth Spray on Oral Health Status and S.Mutans Levels in Paediatric Patients
Status: COMPLETED
Conditions: Gingivitis|Plaque Induced Gingivitis
Interventions: PROCEDURE: Standard preventive advice+ enzymatic mouth sprays ( Oral7 mouth spray)|PROCEDURE: Standard Preventive Advice + placebo mouth spray ( normal saline mouth spray )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Omission of Dexamethasone in Premedication Regimens During Paclitaxel Treatment
Status: NOT_YET_RECRUITING
Conditions: Cancer
Interventions: DRUG: Dexamethasone|DRUG: H1 Antihistaminics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of rTMS on Cognitive Functions and Behavior in Individuals With Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DEVICE: Stimulation with low frequency rTMS at 1 Hz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of DTM™ SCS Therapy Combined With Conventional Medical Management (CMM) to CMM Alone in the Treatment of Intractable Back Pain Subjects Without Previous History of Lumbar Spine Surgery
Status: COMPLETED
Conditions: Pain, Intractable|Pain, Chronic
Interventions: DEVICE: DTM™ spinal cord stimulation therapy delivered via Intellis™ neurostimulator system|OTHER: Conventional Medical Management (CMM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lidocaine in Carcinologic ENT Surgery: A Trial for Evaluation of Opioid Saving Strategy and Chronic Post-surgical Pain (ELICO)
Status: COMPLETED
Conditions: Carcinologic Ear, Nose, and Throat (ENT) Surgery
Interventions: DRUG: Lidocaine 20mg/ml|DRUG: Glucose 5% (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Injectable DMAU for Male Contraception in Healthy Male Volunteers (CCN015)
Status: RECRUITING
Conditions: Healthy Men|Male Contraception
Interventions: DRUG: Dimethandrolone Undecanoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Deferiprone Delayed Release Tablets and Deferiprone Oral Solution in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Deferiprone delayed release tablet formulation|DRUG: Deferiprone oral solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Randomized Trial of In-Home Cervical Cancer Screening in Underscreened Women
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BEHAVIORAL: Mailed in-home high-risk HPV testing kit|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses to Exercise in Obese Males
Status: COMPLETED
Conditions: Obesity Adult Onset
Interventions: DIETARY_SUPPLEMENT: Grape Seed Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Itopride on Gastric Motor and Sensory Functions in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Itopride 100 mg|OTHER: Placebo|DRUG: Itopride 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Drug Levels of Iplimumab Given Under the Skin Alone and in Combination With Nivolumab in Multiple Tumor Types
Status: TERMINATED
Conditions: Tumor
Interventions: DRUG: ipilimumab|DRUG: nivolumab|DRUG: ENHANZE (rHuPH20)|DRUG: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of the Detection of Hyper-virulent Clone ST17 of Group B Strep (GBS) for the Prevention of Neonatal GBS Meningitis
Status: COMPLETED
Conditions: Neonatal Infections Colonize With Group B Streptococci
Interventions: OTHER: Samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Phase III Study of SHR-A1811 Injection With or Without Pertuzumab in HER2-Positive Recurrent or Metastatic Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-PositiveRecurrent or Metastatic Breast Cancer
Interventions: DRUG: SHR-A1811 Injection|DRUG: SHR-A1811 Injection ； Pertuzumab Injection|DRUG: Trastuzumab Injection；Pertuzumab Injection ； Docetaxel Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Tissue Freezing For Fertility Preservation In Women Facing A Fertility Threatening Medical Diagnosis/Treatment
Status: COMPLETED
Conditions: Cancer|Hematologic Disorder|Rheumatologic Disorder|Infertility
Interventions: PROCEDURE: Ovarian Cryopreservation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, and Pharmacokinetics of ABT-354 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: ABT-354|DRUG: ABT-354|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Erythroferrone as a New Biomarker of Erythropoesis Stimulating Agents
Status: UNKNOWN
Conditions: Sports Drug Abuse
Interventions: DRUG: EPREX|DRUG: sodium chloride AGUETTANT 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Core Stability Exercises With and Without Treadmill Training on Balance in Children With Down Syndrome
Status: UNKNOWN
Conditions: Down Syndrome
Interventions: OTHER: core stability exercises with treadmill|OTHER: core stability exercise without treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early hGH Treatment of SGA Infants to Prevent Irreversible Neurologic and Psychological Damage and Sequelae
Status: UNKNOWN
Conditions: Infant, Small for Gestational Age|Growth Hormone Treatment|Infant, Premature, Diseases
Interventions: DRUG: Human growth hormone,ZOMACTON® (somatropin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Higher Protein Diet and Exercise for Optimal Weight Loss in Elderly Women
Status: COMPLETED
Conditions: Bone and Body Composition|Obesity|Metabolic Syndrome|Physical Function|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Whey protein isolate|DIETARY_SUPPLEMENT: Maltodextrin powder supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacogenomics IND EXEMPT SNP Clinical Study - Crizotinib and Single Nucleotide Polymorphisms
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Crizotinib - Usual|DRUG: Crizotinib - Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prospective Study on the Value of Subcutaneous Drains in Gastrointestinal Surgery
Status: COMPLETED
Conditions: Digestive System Diseases [C06]|Digestive System Neoplasms [C04.588.274]
Interventions: DEVICE: Redon drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Breast Cancer Study of the Netherlands Working Party for Autotransplantation in Solid Tumors
Status: TERMINATED
Conditions: High-Risk Breast Cancer
Interventions: PROCEDURE: stem cell reinfusion|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Cirrhosis|Hepatocellular Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|OTHER: Placebo Administration|OTHER: Questionnaire Administration|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Stress Ball Intervention During Non-Stress Test on Anxiety and Fetal Well-Being in High-Risk Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Fetal Conditions|Pregnancy Related
Interventions: BEHAVIORAL: Stress Ball Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapy and Radiation Therapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: mesna|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemostatic Closure of Femoral Artery Access Site, Using the QuickClose Design 9 System
Status: WITHDRAWN
Conditions: Coagulation|Therapeutic Uses|Pharmacologic Actions
Interventions: DEVICE: closure device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Long-term Effect of High Flow Nasal Canula Therapy on Obstructive Sleep Apnea
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|High Flow Nasal Canula|Continuous Positive Airway Pressure Ventilation
Interventions: DEVICE: CPAP|DEVICE: high-flow nasal canula oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Trial Protocol for the Influenza Virus Vaccine (Split Virion, Inactivated)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine|BIOLOGICAL: Influenza Virus Vaccine(contains Preservative)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Efficacy of Anesthesia Administered by Endoscopist or Anesthesiologist on Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy|Ketamine|Fentanyl
Interventions: DRUG: Ketamine|DRUG: fentanyl|DEVICE: patient control analgesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PK/PD and Steady State Efficacy Study of Bilastine Compared With Placebo Given Orally in the Treatment of the Symptoms of SAR in an EEC Model (5-arm)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis|Hay Fever|Rhinoconjunctivitis
Interventions: DRUG: Bilastine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neural Basis of Decision-Making Deficits in Traumatic Brain Injury
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: DEVICE: tDCS|DRUG: [11C] Raclopride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of the Combination of Trastuzumab Plus TUCAtinib Plus viNorelbine in Patients With HER2-positive Non-resectable Locally Advanced or Metastatic Breast Cancer
Status: RECRUITING
Conditions: HER2-positive Metastatic Breast Cancer|Locally Advanced HER2 Positive Breast Carcinoma
Interventions: DRUG: Tucatinib|DRUG: Trastuzumab|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Tarceva (Erlotinib) in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer Following 4 Cycles of Platinum-based Chemotherapy Without Disease Progression
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Anti-PD-1 (Nivolumab) in Bladder Cancer Patients Recently Treated With Intravesical BCG Immunotherapy
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Nivolumab|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Collagen Bupivacaine Implant in Women Following Abdominal Hysterectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine Collagen Sponge (CollaRx®)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the Safety and Efficacy of Moxifloxacin Ophthalmic Solution 0.5% ((VIGAMOX®) Versus Ofloxacin Ophthalmic Solution 0.3% in the Treatment of Bacterial Conjunctivitis in Chinese Patients
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: Moxifloxacin ophthalmic solution, 0.5%|DRUG: Ofloxacin ophthalmic solution, 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Learn More About the Long-Term Responses to Treatment With Regorafenib in Patients With Metastatic Colorectal Cancer in the United States
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prebiotic Treatment in People With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DIETARY_SUPPLEMENT: Prebiotic|DIETARY_SUPPLEMENT: Placebo Prebiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-4083 Capsules When Given Alone or In Combination With Albendazole Capsules Moves in The Body of Adult Participants With Onchocerca Volvulus Infection
Status: TERMINATED
Conditions: Onchocerciasis
Interventions: DRUG: ABBV-4083|DRUG: Placebo for ABBV-4083|DRUG: Albendazole|DRUG: Placebo for Albendazole|DRUG: Placebo for Ivermectin|DRUG: Ivermectin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Autologous Adipose-Derived Stromal Vascular Fraction To Treat Osteoarthritis of Hip, Knee, Ankle, and Thumb Joints
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: PROCEDURE: Cell injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of RO7434656 in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
Status: RECRUITING
Conditions: Primary IgA Nephropathy
Interventions: DRUG: RO7434656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fluid Output Threshold for Safe Chest Tube Removal - A Potential Way to Decrease Length of Stay in Hospital and to Improve Postoperative Care After Lung Surgery?
Status: COMPLETED
Conditions: Pleural Effusion Recurrence|Pulmonary Resection|Chest Tube Management
Interventions: PROCEDURE: Traditional|PROCEDURE: Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Efficacy and Safety of Prandilin and NovoRapid in Newly Diagnosed Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: aspart insulin or lipro insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effect of High-protein Meals in Men
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Whey protein native|OTHER: Whey protein microgels|OTHER: Hydrolyzed whey protein|OTHER: Casein native|OTHER: Hydrolyzed casein|OTHER: Total milk protein native|OTHER: Hydrolyzed milk protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: DCE-MRI Guided Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Borderline-resectable Pancreatic Cancer
Interventions: DEVICE: Point-of-care Portable Perfusion Phantom (P4)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analytical Validation of the abioSCOPE Device With the in Vitro Device (IVD) CAPSULE PSP Test: Comparison of PSP Values Measured With Venous Whole Blood and Those Measured With Arterial Whole Blood
Status: COMPLETED
Conditions: Pancreatic Stone Protein|Device
Interventions: DEVICE: measurement of PSP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Wilm's Tumor 1 Protein Vaccine to Treat Cancers of the Blood
Status: COMPLETED
Conditions: Leukemia, Acute Myelogenous (AML)|Leukemia, Acute Lymphocytic (ALL)|Leukemia, Chronic Myelogenous (CML)|Myelodysplastic Syndrome (MDS)|Non-Hodgkin's Lymphoma (NHL)
Interventions: DRUG: WT1 Peptide-Pulsed Dendritic Cells|DRUG: Donor Lymphocytes|DRUG: IL-4|DRUG: KLH|DRUG: WT1 Peptides|DRUG: Endotoxin|DRUG: Diphenhydramine|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DRUG: Diosmin|DRUG: Diosmin / Hesperidin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep-Wake Patterns on Illness Trajectories and Treatment Response in MDD
Status: NOT_YET_RECRUITING
Conditions: Depression|Sleep Disorders, Circadian Rhythm
Interventions: BEHAVIORAL: Transdiagnostic Intervention for Sleep and Circadian Dysfunction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ramucirumab Combined With Nab-paclitaxel, Lobaplatin, and S-1 in Neoadjuvant Transformation Therapy for Advanced Gastric Cancer
Status: RECRUITING
Conditions: Advanced Gastric Cancer
Interventions: DRUG: nab-paclitaxel, lobaplatin, and S-1 combined with ramucirumab|DRUG: nab-paclitaxel, lobaplatin, and S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroimaging of the Effects of Concerta in the Treatment of ADHD
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: methylphenidate-OROS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Pilot Study of Terazosin in Treatment of Antidepressant Induced Excessive Sweating
Status: COMPLETED
Conditions: Antidepressant Induced Excessive Sweating
Interventions: DRUG: terazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Electrical Stimulation Study for Visual Hallucinations
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder
Interventions: DEVICE: transcranial electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test Whether BI 425809 Influences the Amount of Midazolam in the Blood
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: midazolam|DRUG: BI 425809
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Bimatoprost in Men With Androgenetic Alopecia (AGA)
Status: TERMINATED
Conditions: Alopecia|Alopecia, Androgenetic|Baldness
Interventions: DRUG: Bimatoprost
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nefazodone in the Treatment of Cocaine Dependence and Depression - 4
Status: COMPLETED
Conditions: Cocaine-Related Disorders|Substance-Related Disorders
Interventions: DRUG: Nefazodone|BEHAVIORAL: Psychosocial Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Direct Access Carotid Artery Stenting Using the Neuroguard IEP System (PERFORMANCE III)
Status: RECRUITING
Conditions: Carotid Stenosis|Carotid Artery Diseases
Interventions: DEVICE: Neuroguard IEP Direct System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Rehabilitation After Stroke
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: donepezil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of MSRD-100 in Subjects With Atopic Dermatitis >=3 Months of Age and Older
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: DRUG: MSRD-100|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dietary Fibre and Plant Protein on Appetite and Metabolic Function
Status: COMPLETED
Conditions: Appetite Regulation
Interventions: OTHER: Rye + high dose inulin + low dose gluten|OTHER: Rye + equal doses of inulin & gluten|OTHER: Rye + low dose inulin + high dose gluten|OTHER: Large non-supplemented rye|OTHER: Small non-supplemented rye|OTHER: Refined wheat bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes
Status: COMPLETED
Conditions: Athlete
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: Coenzyme Q10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury
Status: TERMINATED
Conditions: Traumatic Thoracic Acute Spinal Cord Injury
Interventions: DEVICE: Neuro-Spinal Scaffold
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Exisulind in Treating Patients Who Are Undergoing Radical Prostatectomy for Stage II or Stage III Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: exisulind|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cerebellar Stimulation and Cognitive Control
Status: RECRUITING
Conditions: Schizophrenia|Autism Spectrum Disorder|Bipolar Disorder|Depression|Parkinson Disease
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biventricular Epicardial Pacing Post Cardiac Surgery in Patients With Left Ventricular Ejection Fractions Less Than 45%
Status: UNKNOWN
Conditions: Heart Failure
Interventions: OTHER: Biventricular pacing post cardiac surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of a Screening Approach for Sexual Dysfunction in AYA Patients With and Surviving Childhood Cancer
Status: RECRUITING
Conditions: Pediatric Cancer|Survivorship
Interventions: BEHAVIORAL: Sexual Function Screening Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Double-blind Trial of Mannitol Cream to Block the Effect of Capsaicin Cream
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: 30% Mannitol in vehicle cream|DRUG: vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Twice Daily Treatment With Amoxicillin for Non-severe Community Acquired Pneumonia.
Status: RECRUITING
Conditions: Community-acquired Pneumonia
Interventions: DRUG: Amoxicillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Fish-oil Lipid Emulsions on Neonatal Morbidities
Status: COMPLETED
Conditions: Retinopathy of Prematurity|Neonatal Cholestasis
Interventions: DIETARY_SUPPLEMENT: Fish-oil emulsions|DIETARY_SUPPLEMENT: soybean-oil emulsion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Conservative Interventions on the Signs and Symptoms of Diastasis Recti
Status: COMPLETED
Conditions: Diastasis Recti And Weakness Of The Linea Alba
Interventions: OTHER: Exercise therapy|OTHER: Abdominal binding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a Fluoroquinolone to Treat Complicated Skin Infections
Status: COMPLETED
Conditions: Skin Structure Infections|Bacterial Skin Diseases|Staphylococcal Skin Infections
Interventions: DRUG: delafloxacin|DRUG: delafloxacin|DRUG: tigecycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018)
Status: TERMINATED
Conditions: Middle Cerebral Artery Stroke
Interventions: DRUG: Comparator: Placebo|DRUG: Comparator: MK0724
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Scheme of Limb Warming Blanket Combined With Dexmedetomidine
Status: COMPLETED
Conditions: Spine Surgery|Postoperative Delirium and Chills
Interventions: DRUG: Dexmetomidine|DEVICE: Lower limb heating blanket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of MIL62 in Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD)
Status: RECRUITING
Conditions: Neuromyelitis Optica Spectrum Disorder
Interventions: DRUG: MIL62|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Endothelial Function in Patients With Non Alcoholic Fatty Liver Disease and the Impact of Statin Treatment
Status: WITHDRAWN
Conditions: Non Alcoholic Fatty Liver Disease
Interventions: DRUG: atorvastatin|BEHAVIORAL: lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TENS and Taping for Older People
Status: NOT_YET_RECRUITING
Conditions: Postural|Defect
Interventions: BEHAVIORAL: TENS and KT|BEHAVIORAL: TENS and sham taping|BEHAVIORAL: KT and sham TENS|BEHAVIORAL: Sham TENS and sham taping
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Chicken Egg Antibody (IgY) (COVID-19)
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: anti-SARS-CoV-2 IgY|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics of the Brimonidine Tartrate Posterior Segment Delivery System in Patients Undergoing Pars Plana Vitrectomy
Status: COMPLETED
Conditions: Vitrectomy
Interventions: DRUG: 400 µg Brimonidine Tartrate Implant|DRUG: 200 µg Brimonidine Tartrate Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Neoadjuvant Docetaxel and Cyclophosphamide in Locally Advanced or Node Positive Primary Breast Cancer With Companion Pharmacokinetic and Pharmacogenomic Analyses
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Neoadjuvant Docetaxel and Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiometabolic Effects of Combined Aerobic Exercise and Non-Exercise Physical Activity
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight
Interventions: BEHAVIORAL: Aerobic Exercise|BEHAVIORAL: Increasing non-Exercise Physical Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Assess the Safety and Efficacy of Probiotic to Modulate Psychological Stress
Status: COMPLETED
Conditions: Stress, Psychological|Healthy
Interventions: BIOLOGICAL: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of GM-CSF Supplemented IVF Medium in Patients With Recurrent Implantation Failure
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: GM-CSF medium|DRUG: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Residual Inflammation and Plaque Progression Long-term Evaluation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atherosclerosis|Myocardial Infarction|Coronary Artery Disease|Inflammation
Interventions: DIAGNOSTIC_TEST: PET imaging|DIAGNOSTIC_TEST: Coronary CT angiography|DIAGNOSTIC_TEST: Cardiac MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized, Double-blind Study to Assess the Safety and Efficacy of EDP-305 in Subjects With Liver-biopsy Proven NASH
Status: TERMINATED
Conditions: Non-Alcoholic Steatohepatitis
Interventions: DRUG: EDP-305 1.5 mg|DRUG: EDP-305 2 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Clean Intermittent Catheterization (CIC) in Multiple Sclerosis (MS) Patients With Bladder Dysfunction
Status: TERMINATED
Conditions: Bladder Dysfunction|Multiple Sclerosis
Interventions: DEVICE: CIC using LoFric Primo|DRUG: Anticholinergic medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dehydration of Omafilcon A Contact Lenses Versus Delefilcon A Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: omafilcon A|DEVICE: delefilcon A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Misodel® in Comparison With Orally Administrated Misoprostol (Cytotec®) at Induction of Labour
Status: UNKNOWN
Conditions: Induced Deliveries
Interventions: DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advancing Tools for Human Early Lifecourse Exposome Research and Translation- Adolescence Follow-up of the HELIX Subcohort
Status: COMPLETED
Conditions: Exposure|Health Behavior|Environment
Interventions: OTHER: HELIX's follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Observe Treatment Patterns and Outcomes in Participants in Saudi Arabia With Human Epidermal Growth Factor Receptor 2 (HER2-Positive) Unresectable Locally Advanced or Metastatic Breast Cancer (LA/mBC)
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases
Status: WITHDRAWN
Conditions: Recurrent Melanoma|Stage IV Melanoma|Tumors Metastatic to Brain
Interventions: DRUG: Vemurafenib|RADIATION: Whole-brain radiation therapy (WBRT)|RADIATION: Radiosurgery (SRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth
Status: UNKNOWN
Conditions: Pulp Necrosis
Interventions: DEVICE: Photo Activated Disinfection|DRUG: antibiotic paste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2a Study of PGT121, VRC07-523LS and PGDM1400 Monoclonal Antibodies in HIV-uninfected and HIV-infected Adults
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: BIOLOGICAL: PGT121 + VRC07-523LS|BIOLOGICAL: PGT121 + VRC07-523LS + PGDM1400
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pembrolizumab, Dabrafenib, and Trametinib Before Surgery for the Treatment of BRAF-Mutated Anaplastic Thyroid Cancer
Status: RECRUITING
Conditions: Thyroid Gland Anaplastic Carcinoma|Thyroid Gland Squamous Cell Carcinoma
Interventions: PROCEDURE: Conventional Surgery|DRUG: Dabrafenib|RADIATION: Intensity-Modulated Radiation Therapy|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Valacyclovir Hydrochloride Tablets 1gm Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Valacyclovir hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Randomized Controlled Trial of Group Psychotherapy Interventions for Cancer Patients
Status: COMPLETED
Conditions: Palliative Care
Interventions: BEHAVIORAL: Meaning Centered Group Psychotherapy|BEHAVIORAL: Supportive Group Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: [18F]PSMA-11 PET/CT Phase 3 Clinical Study
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: [18F]PSMA-11|DIAGNOSTIC_TEST: [68Ga]PSMA-11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Improvement Of Pelvic Exams for Patients With Chronic Vulvovaginal Conditions
Status: COMPLETED
Conditions: Pain
Interventions: DIAGNOSTIC_TEST: Experimental Pelvic Exam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION