pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy, Safety, Tolerability and Pharmacokinetics (PK) of Nilotinib (AMN107) in Pulmonary Arterial Hypertension (PAH)
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Nilotinib|DRUG: Placebo to nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of a Fixed Dose Combination Tablet Containing 200 mg Ibuprofen and 30 mg Pseudoephedrine-HCl Compared to RhinAdvil(R)(200 mg Ibuprofen and 30 mg Pseudoephedrine-HCl) as a Fixed Dose Combination Tablet Administered in Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibuprofen|DRUG: Ibuprofen|DRUG: Pseudoephedrine-HCl|DRUG: Pseudoephedrine-HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of BND-35 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: BND-35|DRUG: Nivolumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas
Status: UNKNOWN
Conditions: Infantile Hemangioma
Interventions: DRUG: oral propranolol|DRUG: oral atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of E2511 in Healthy Adult and Elderly Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: E2511|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Clinical Trial Comparing Gemcitabine and Carboplatin With and Without P276-00 in Subjects With Metastatic Triple Negative Breast Cancer, With a Run-in of Escalating Dose of P276-00 Added to Gemcitabine and Carboplatin
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Gemcitabine and Carboplatin|DRUG: P276-00 along with Gemcitabine and carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance Exercise in Healthy Men
Status: COMPLETED
Conditions: Single Bout of Resistance Type Exercise|Standardized Diet
Interventions: BEHAVIORAL: Adhere to a specific standardized diet for 4 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ticagrelor Versus Prasugrel in Acute Coronary Syndromes After Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Coronary Artery Disease|Acute Coronary Syndrome
Interventions: DRUG: Prasugrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)
Status: COMPLETED
Conditions: Postsurgical Pain
Interventions: DRUG: CA-008|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety/Efficacy of Two Treatment Regimens for Vectical™ Ointment & Clobex® Spray for Moderate Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Vectical™ Ointment weekdays and Clobex® Spray weekends regimen|DRUG: Clobex® Spray morning and Vectical™ Ointment evening regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Study of MYOBLOC for the Treatment of Sialorrhea in Parkinson's Disease Patients
Status: COMPLETED
Conditions: Drooling
Interventions: BIOLOGICAL: Botulinum Toxin Type B (Myobloc)|BIOLOGICAL: Matched placebo to Myobloc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating the Pharmacokinetic and Pharmacodynamic Properties of FIAsp in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: Faster-acting insulin aspart|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Monolaurin Ointment Versus Mupirocin Ointment
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: Monolaurin|DRUG: Mupirocin ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the What the Body Does to the Drug in Subjects With Mild, Moderate, and Severe Liver Dysfunction
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)|Binge-Eating Disorder Disorder
Interventions: DRUG: dasotraline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Intra-articular Infiltrations of PRP, MFAT, and PRP-MFAT in the Treatment of Symptomatic Knee Osteoarthritis.
Status: NOT_YET_RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: BIOLOGICAL: Intra-articular injection of autologous microfat|BIOLOGICAL: Intra-articular injection of autologous platelet-rich plasma|BIOLOGICAL: Intra-articular injection of autologous microfat and platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The CogNaive Study: Assessing Changes in Neurocognitive Function in Treatment Naïve HIV-1 Positive Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: nevirapine|DRUG: atazanavir/ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Treatment for Advanced Rectal Carcinoma
Status: COMPLETED
Conditions: Rectal Carcinoma
Interventions: RADIATION: 50 Gy|DRUG: Capecitabine|RADIATION: 25 Gy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Trial With GlyTI-M Among Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: ADHD
Interventions: DRUG: GlyTI-M|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Soy and Brain Vascular Function
Status: COMPLETED
Conditions: Brain Vascular Function|Cerebral Blood Flow|Glucose Metabolism|Cognitive Performance
Interventions: DIETARY_SUPPLEMENT: Soy nuts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Incisional Negative Pressure Wound Therapy in High Risk Patients Undergoing Panniculectomy: A Prospective Randomized Controlled Trial
Status: TERMINATED
Conditions: Complications Wounds|Negative Pressure Wound Therapy|Wound Healing Delayed|Incisional|Panniculectomy|Incisional Negative Pressure Wound Therapy|Incisional Vac|Wound Vac|Obese|Renal Failure|Kidney Transplant; Complications|Wound Healing Complication
Interventions: PROCEDURE: Incisional Negative Pressure Wound Therapy|PROCEDURE: Standard Closure with Skin Glue|DEVICE: PICO (Smith&Nephew)|DEVICE: Dermabond
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Impact of Warmed Carbon Dioxide Insufflation During Colonoscopy on Polyp Detection
Status: TERMINATED
Conditions: Colonic Polyps|Colonic Neoplasms
Interventions: DEVICE: room temperature air insufflation|DEVICE: warmed carbon dioxide insufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Listed Music With Motivational Video And Nutrition on Non-Stress Test and Anxiety Level of Mother
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: DIETARY_SUPPLEMENT: Cake + fruit juice|OTHER: Video group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of the Efficacy and Safety of Beclomethasone Dipropionate Plus Formoterol vs Fluticasone Propionate Plus Salmeterol in the 6 Months Step Down Treatment of Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Beclomethasone plus formoterol fixed combination|DRUG: Fluticasone plus salmeterol fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of SyB L-0501 in Combination With Rituximab to Treat Recurrent/Relapsed Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Assess the Efficacy and Safety of SyB L-0501 in Combination With Rituximab in Patients With Recurrent or Relapsed DLBCL
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunogenicity, Safety and Antibody Persistence of COVID-19 Booster Vaccine (Produced in Wuhan) in Patients With Hypertension and/or Diabetes
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: BIOLOGICAL: Covid-19 vaccine (0-1-4 schedule)|BIOLOGICAL: Covid-19 vaccine (0-1-6 schedule)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Retrospective Chart Review of the 5 & 2 & 2 and 4 & 2 & 1 Plans
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: 5 & 2 & 2 Plan|OTHER: 4 & 2 & 1 Plan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Induced Wound Healing by Application of Expanded Bone Marrow Stem Cells in Diabetic Patients With Critical Limb Ischemia
Status: COMPLETED
Conditions: Diabetic Foot
Interventions: BIOLOGICAL: tissue repair cells (TRC)|BIOLOGICAL: bone marrow stem cells (BMC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Adjunctive Metformin on Metabolic Profiles in Clozapine-treated Schizophrenic Patients
Status: UNKNOWN
Conditions: Obesity|Metabolic Syndrome|Schizophrenia
Interventions: DRUG: Metformin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study With Health Educational Material on Health Promotion in Cancer Survivors
Status: UNKNOWN
Conditions: Stomach Cancer|Colon Cancer|Thyroid Cancer|Breast Cancer
Interventions: BEHAVIORAL: Brochure of Secondary Cancer Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Laryngeal Mask Supreme™ Versus the I-gel™
Status: COMPLETED
Conditions: Patients Undergoing Elective General Anesthesia
Interventions: DEVICE: I-gel and LMA Supreme: supraglottic airway devices
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of Aromatherapy to Reduce Symptom Burden
Status: COMPLETED
Conditions: Anxiety|Chemotherapy-induced Nausea and Vomiting
Interventions: DRUG: Essential oils|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MIH and Hypersensitivity in Children
Status: RECRUITING
Conditions: Dentin Sensitivity|Molar Incisor Hypomineralization
Interventions: OTHER: CPP-ACPF|OTHER: PBMT|OTHER: CPP-ACPF+PBMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study to Evaluate the Safety and Tolerability of VK2735
Status: RECRUITING
Conditions: Weight Loss|NASH
Interventions: BIOLOGICAL: VK2735|BIOLOGICAL: Placebo|DRUG: VK2735 Placebo|DRUG: VK2735 Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)
Status: RECRUITING
Conditions: Invasive Fungal Infection
Interventions: DRUG: Posaconazole IV 6 mg/kg|DRUG: Posaconazole PFS 6 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of SCT-I10A Combined SCT200 or SCT-I10A Combined SCT200 Plus Chemotherapy in ESCC and CRC
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma|Colorectal Cancer
Interventions: BIOLOGICAL: SCT-I10A|BIOLOGICAL: SCT200|OTHER: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Individualized Stereotactic Body Radiation Therapy (SBRT) for Intrahepatic Cancer
Status: COMPLETED
Conditions: Liver Cancer|Hepatocellular Cancer
Interventions: RADIATION: individualized Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Increasing Physical Activity Among Sedentary Older Adults:What, Where, When, and With Whom
Status: COMPLETED
Conditions: Sedentary Lifestyle|Self Efficacy|Control Locus|Aging
Interventions: BEHAVIORAL: App Experimental condition|BEHAVIORAL: App Condition Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety, and Tolerability of Atogepant for the Prevention of Chronic Migraine
Status: COMPLETED
Conditions: Chronic Migraine
Interventions: DRUG: Atogepant 30 mg|DRUG: Atogepant 60 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Gentamicin & Amoxicillin x 7days|DRUG: Penicillin & gentamicin x 2 d + Amoxicillin X 5 d|DRUG: Standard reference therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interaction of Caffeine and Hydration on Voice
Status: COMPLETED
Conditions: Voice Disorders
Interventions: DRUG: C2 (200mg of caffeine; 1/2 L of water)|DRUG: C3(200mg of caffeine; 1 L of water)|DRUG: C1 (200mg of caffeine, no water)|DRUG: Placebo (no caffeine, no water).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immune Response and Risk of Side Effects After Influenza Vaccination in Athletes
Status: COMPLETED
Conditions: Influenza Virus Vaccine Adverse Reaction|Influenza Vaccine Allergy
Interventions: BIOLOGICAL: Influenza Vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness and Safety of Shaoyao Gancao Decoction With Addition on the Sleep-related Leg Cramps
Status: NOT_YET_RECRUITING
Conditions: Sleep-related Leg Cramps
Interventions: DRUG: Shaoyao Gancao Decoction with Addition|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Involvement in Scleroderma: A Clinical Study of the Safety and Efficacy of Mycophenolate Mofetil in Scleroderma Patients With Lung Involvement
Status: COMPLETED
Conditions: Scleroderma, Systemic
Interventions: DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Different Drugs to Control Post Root Canal Treatment Pain
Status: COMPLETED
Conditions: Pain|Postoperative Pain|Irreversible Pulpitis
Interventions: PROCEDURE: Root Canal Treatment|DRUG: Paracetamol|DRUG: Ibuprofen|DRUG: Mefenamic acid|DRUG: Diclofenac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FOLFOX4 Combined With Endostar in Patients With Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: DRUG: Folfox4 plus recombinant human endostatin (Endostar)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination of Anti-PD1 Antibody-activated TILs and Chemotherapy in Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer Stage III
Interventions: BIOLOGICAL: anti-PD-1 antibody-activated TILs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of and Immunogenicity to an H1N1 Influenza Vaccine in HIV-infected Adults
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: Adjuvanted vaccine against H1N1 influenza virus (GSK)|BIOLOGICAL: Adjuvanted vaccine against H1N1 influenza virus (GSK)|BIOLOGICAL: Adjuvanted vaccine against H1N1 influenza virus (GSK)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing AlloDerm and DermACELL in Breast Reconstruction
Status: COMPLETED
Conditions: Acellular Dermal Matrix in Breast Reconstruction
Interventions: OTHER: AlloDerm|OTHER: DermACELL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Feasibility Randomised-Controlled Trial of Online Stroke Interventions
Status: COMPLETED
Conditions: Stroke
Interventions: BEHAVIORAL: Getting things done after stroke|BEHAVIORAL: Stroke psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: When Heparin Stopped for Anticoagulation During ECMO Decannulation
Status: UNKNOWN
Conditions: Extracorporeal Membrane Oxygenation
Interventions: OTHER: Heparin stopped before ECMO decannulation|OTHER: Heparin reduced after ECMO decannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Cold Snare Polypectomy (CSP) of Intermediate Sized Colorectal Polyps 10-15 mm
Status: UNKNOWN
Conditions: Colorectal Polyp|Colorectal Adenoma
Interventions: DEVICE: Cold Snare Polypectomy of intermediate sized polyps (10-15 mm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Acupuncture and Electroacupuncture in Patients With Chronic Nonspecific Low Back Pain: Randomized Clinical Trial
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DEVICE: Acupuncture|DEVICE: Electroacupuncture (device 585)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: No endocrine therapy|OTHER: Endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Night-time Blood Pressure to Treat Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: treatment of BP by using night-time BP|BEHAVIORAL: treatment of BP by using daytime BP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Tolerability of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: MEDI0382|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ReCoUPS: Post-Concussion Patient Reports
Status: COMPLETED
Conditions: Brain Concussion|Head Injury
Interventions: BEHAVIORAL: Streak incentive|BEHAVIORAL: Loss-based incentive|BEHAVIORAL: Flat-fee control status quo condition|BEHAVIORAL: Flat-Fitbit control status quo condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of TQ-B3234 in Patients With Type I Neurofibromatosis
Status: NOT_YET_RECRUITING
Conditions: Type I Neurofibromatosis
Interventions: DRUG: TQ-B3234 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans
Status: WITHDRAWN
Conditions: Menopause|Prediabetes|Obesity
Interventions: OTHER: Placebo|DRUG: conjugated estrogens/bazedoxifene (CE/BZA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma
Status: COMPLETED
Conditions: Rhabdoid Tumors|INI1-negative Tumors|Synovial Sarcoma|Malignant Rhabdoid Tumor of Ovary
Interventions: DRUG: Tazemetostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of the Individual Auditory-cognitive Need on the Aided Benefit Using Different Feature Settings
Status: RECRUITING
Conditions: Speech Intelligibility|Hearing Loss, Sensorineural
Interventions: DEVICE: Hearing aid feature adjustment (frequency compression) of the following hearing aids: Phonak Audéo Paradise/Lumity 70|DEVICE: Hearing aid feature adjustment (noise reduction) of the following hearing aids: Phonak Audéo Paradise/Lumity 70|BEHAVIORAL: Cognitive screening and vision screening|BEHAVIORAL: Audiological Assessment|BEHAVIORAL: Questionnaires|BEHAVIORAL: Cognition|OTHER: Real ear measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Novel Intervention Linking Public Housing With Primary Care to Prevent Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus Risk|Obesity|Cardiovascular Risk Factor
Interventions: BEHAVIORAL: 24 week community based DPP Group Lifestyle Balance Program|BEHAVIORAL: Wait-List Control community based DPP Group Lifestyle Balance Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiofrequency Neurotomy In Relieving Chronic Knee Pain
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Pain, Chronic
Interventions: PROCEDURE: radiofrequency|DRUG: Paracetamol (conventional)|DRUG: Ketorolac Tromethamine (conventional)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Manual Lymphatic Drainage for Rheumatoid Arthritis
Status: COMPLETED
Conditions: Effect of Manual Lymphatic Drainage on Upper Extremity Functionality in Rheumatoid Arthritis
Interventions: OTHER: manual lymphatic drainage|OTHER: excersize
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Very low nicotine content cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Volume Reduction of Uterine Fibroids After Embolization or Microwave Treatment
Status: UNKNOWN
Conditions: Uterine Fibroids
Interventions: DEVICE: Microwave treatment|PROCEDURE: uterine artery embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Lung Disease (COLD)
Interventions: DRUG: Amoxicillin-clavulanic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Intermittent Hypoxia in Upper and Lower Limb Functions in Persons With Incomplete Spinal Cord Injury
Status: RECRUITING
Conditions: Incomplete Spinal Cord Injury
Interventions: OTHER: Device induce acute intermittent hypoxia 9 % of Oxygen|OTHER: Normoxia 21% of oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Restitution Time in Treatment of Patellar Tendinopathy
Status: RECRUITING
Conditions: Patellar Tendinopathy|Jumper's Knee
Interventions: OTHER: Resistance training for knee extensors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Various Doses of Hydroxychloroquine in Pre-Exposure Prophylaxis for COVID 19
Status: UNKNOWN
Conditions: COVID 19
Interventions: DRUG: Hydroxychloroquine Sulfate 200 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy
Status: NOT_YET_RECRUITING
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves for theTreatment of Lumbar Facet Syndrome
Status: COMPLETED
Conditions: Low Back Pain
Interventions: PROCEDURE: Conventional radiofrequency ablation (RFA)|PROCEDURE: Cooled Radiofrequency Ablation (CRFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of an Enhanced Patient Reported Outcome Measurement (PROM) Strategy on PROM Completion Rates
Status: RECRUITING
Conditions: PROM
Interventions: OTHER: Usual PROMs and new PROMs strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Depth of Total Intravenous Anesthesia Using Propofol on Postoperative Cognitive Dysfunction
Status: UNKNOWN
Conditions: Cognition Disorders
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial Comparing Quadratus Lumborum Block (QLB) and Paravertebral Block (PVTB) for Postoperative Analgesia in Hepatectomy
Status: UNKNOWN
Conditions: Quadratus Lumborum Block|Thoracic Paravertebral Block|Postoperative Analgesia|Hepatectomy
Interventions: OTHER: Patient-controlled intravenous analgesia|OTHER: Quadratus Lumborum Block|OTHER: Thoracic Paravertebral Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Apatinib for Metastatic Esophageal Cancer.
Status: UNKNOWN
Conditions: Esophageal Cancer|Metastatic Esophageal Cancer|Apatinib
Interventions: DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Drainless Thyroidectomy For Benign Thyroid Diseases Regarding Surgical Site Complications
Status: RECRUITING
Conditions: Benign Thyroid Diseases
Interventions: PROCEDURE: thyroidectomy without drain|PROCEDURE: thyroidectomy with drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light
Status: COMPLETED
Conditions: Sun Damaged Skin
Interventions: OTHER: Solar Simulated Light (SSL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of New Beverages Rich in Bioactive Compounds for the Modulation of Energetic Metabolism in Overweight Adults
Status: COMPLETED
Conditions: Obesity|Inflammation|Insulin Sensitivity
Interventions: DIETARY_SUPPLEMENT: Beverages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimised Fluoride Prevention by Double Rinse With Fluoride and Calcium
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: calcium lactate solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rituximab (Rituxan) for the Prevention of EBV-LPD Epstein Barr Virus (EBV) Lymphoproliferative Disorder Post T Cell Depleted Unrelated and HLA Mis-matched Related HSCT
Status: COMPLETED
Conditions: Hodgkin's Disease|Leukemia|Myelodysplastic Syndrome|Non-Hodgkin's Lymphoma
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody and Sapropterin Dihydrochloride in Patients With PDAC
Status: RECRUITING
Conditions: Pancreatic Adenocarcinoma Metastatic
Interventions: DRUG: Sapropterin Dihydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining Pulmonary Rehabilitation on Discharged COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: OTHER: Pulmonary Rehabilitation (PR)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intratumoral Gene Mediated Cytotoxic Immunotherapy in Patients With Resectable Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: BIOLOGICAL: CAN-2409 + valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance of Multivitamin Supplements After Sleeve Gastrectomy
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Multicentrum® (Pfizer, Spain) 3 months|DRUG: Multicentrum® (Pfizer, Spain) 12 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparative Effects of Modified Otago and Frenkel's Exercises in Geriatric Population
Status: RECRUITING
Conditions: Geriatrics
Interventions: OTHER: Modified Otago exercises|OTHER: Frenkel's exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pneumococcal Vaccine Booster Study in Healthy Children 11-18 Months Old Previously Primed With the Same Vaccines
Status: COMPLETED
Conditions: Hepatitis B|Acellular Pertussis|Tetanus|Poliomyelitis|Diphtheria|Streptococcus Pneumoniae Vaccines
Interventions: BIOLOGICAL: Pneumococcal conjugate vaccine GSK1024850A|BIOLOGICAL: Prevenar|BIOLOGICAL: Infanrix hexa|BIOLOGICAL: Infanrix IPV Hib|BIOLOGICAL: Infanrix penta|BIOLOGICAL: Infanrix IPV|BIOLOGICAL: Meningitec|BIOLOGICAL: NeisVac-C|BIOLOGICAL: Menitorix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab and Lenvatinib in Advanced/Metastatic Neuroendocrine Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer Metastatic|Neuroendocrine Tumors
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Castle Disease Virus (NDV) in Glioblastoma Multiforme (GBM), Sarcoma and Neuroblastoma
Status: WITHDRAWN
Conditions: Glioblastoma|Sarcoma|Neuroblastoma
Interventions: BIOLOGICAL: New Castle Disease Virus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Vitamin D Supplementation as an Adjuvant Therapy inTreatment of Helicobacter Pylori in Children
Status: NOT_YET_RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Vitamin D3|DRUG: Helicobacter pylori triple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effects of VQW-765 vs. Placebo in Performance Anxiety
Status: COMPLETED
Conditions: Performance Anxiety
Interventions: DRUG: VQW-765|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DETERMINE-reduced - Dapagliflozin Effect on Exercise Capacity Using a 6-minute Walk Test in Patients With Heart Failure With Reduced Ejection Fraction
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF)
Interventions: DRUG: Dapagliflozin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Twice Daily Chemoradiation in Addition to Chemotherapy Prior to Surgery in Stage III Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: PROCEDURE: preoperative radiochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-Loop Target Controlled Infusion in Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Cholecystolithiasis
Interventions: DEVICE: Closed-loop TCI|DEVICE: Opened-loop TCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial / Carotid Stenosis
Status: NOT_YET_RECRUITING
Conditions: Cognitive Decline|Cognitive Change|Stenosis|Dementia
Interventions: BEHAVIORAL: Usual Diet advice|BEHAVIORAL: Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: U0289-405: An Open-Label, 12-Week Study to Evaluate the Efficacy and Safety of the Acne System (Benzoyl Peroxide 2.5%, Salicylic Acid 0.5%) in Subjects With Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: OTHER: acne system - benzoyl peroxide 2.5%, Salicyclic Acid 0.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants
Status: COMPLETED
Conditions: Necrotizing Enterocolitis
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: simvastatin|DRUG: B1-6-12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Treatment of Time Deficits in Brain-damaged Patients
Status: COMPLETED
Conditions: Brain Damage
Interventions: BEHAVIORAL: Prismatic googles inducing prismatic adaptation (PA) associated to Virtual Reality (VR)|OTHER: Neutral googles inducing no-adaptation (NA) associated to Virtual Reality (VR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Study in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infants
Interventions: OTHER: Preterm infant formulas and discharge formulas|OTHER: Preterm infant formula with added soluble lipids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Tocotrienols in Post-CABG Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DIETARY_SUPPLEMENT: Tocotrienols|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: EnSite™ HD Grid Catheter AF/AT Mapping Study
Status: COMPLETED
Conditions: Non-paroxysmal Atrial Fibrillation|Left Atrial Tachycardia
Interventions: DEVICE: EnSite™ HD Grid Catheter mapping system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multiple Dose Study of TD-1211 in Healthy Volunteers and Patients With Opioid-Induced Constipation
Status: COMPLETED
Conditions: Healthy|Opioid-induced Constipation
Interventions: DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: TD-1211|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast-enhanced Magnetic Resonance Imaging With Polysaccharide Superparamagnetic Iron Oxide Nanoparticle
Status: COMPLETED
Conditions: Magnetic Resonance Imaging
Interventions: DRUG: polysaccharide superparamagnetic iron oxide injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Helium 4 Optically Pumped Magnetometers : a New Generation of Sensors for High Speed Functional Brain Imaging
Status: UNKNOWN
Conditions: Normal Subject|Patient With Pharmaco-resistant Epilepsy
Interventions: DEVICE: MEG recordings
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Beta-blockers in i-PAH
Status: UNKNOWN
Conditions: Idiopathic Pulmonary Arterial Hypertension
Interventions: DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ritonavir and Its Effects on Biomarkers in Women Undergoing Surgery for Newly Diagnosed Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: ritonavir|PROCEDURE: therapeutic conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Induction Treatment With Velcade and Dexamethasone for Previously Untreated Patients With Multiple Myeloma and Renal Failure
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: velcade
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doravirine for Persons With Excessive Weight Gain on Integrase Inhibitors and Tenofovir Alafenamide
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: Doravirine 100 Mg|DRUG: Tenofovir alafenamide/emtricitabine|DRUG: tenofovir alafenamide/lamivudine|DRUG: Integrase strand transfer inhibitors|DRUG: tenofovir disproxil fumarate/emtricitabine|DRUG: tenofovir disproxil fumarate/lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety of STSA-1002 Following Intravenous Infusion in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: STSA-1002 injection|DRUG: Placebo|DRUG: STSA-1002 injection|DRUG: Placebo|DRUG: STSA-1002 injection|DRUG: Placebo|DRUG: STSA-1002 injection|DRUG: Placebo|DRUG: STSA-1002 injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Management of Endothelial Dysfunction in Patients With Chronic Venous Insufficiency After Endovenous Surgical Procedure
Status: COMPLETED
Conditions: Venous Insufficiency of Leg|Venous Insufficiency (Chronic)(Peripheral)|Endothelial Dysfunction
Interventions: PROCEDURE: Endovenous laser ablation of great saphenous vein (GSV) and microphlebectomy of varicose veins|DRUG: Pharmacotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Live Well: A Practical and Effective Low-Intensity Dietary Counseling Intervention for Use in Primary Care Patients With Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: BEHAVIORAL: Group A: Dietary counseling month 0-6 Group B: Dietary counseling month 3-6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cambridge Brain Mets Trial 1
Status: TERMINATED
Conditions: Lung Cancer|Breast Cancer|Brain Cancer|Advanced Breast Cancer|Advanced Lung Cancer
Interventions: DRUG: Afatinib|RADIATION: 2 Gy targeted radiotherapy|RADIATION: 4 Gy targeted radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acupuncture in Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Active Acupuncture|PROCEDURE: Sham acupuncture|DRUG: flecainide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sleep Extension on Ceramides in People With Overweight and Obesity
Status: RECRUITING
Conditions: Lifestyle Factors|Overweight and Obesity|Insulin Sensitivity|Eating Habit|Sleep Hygiene|Type 2 Diabetes|Sleep|Sleep Deprivation|Insufficient Sleep Syndrome
Interventions: BEHAVIORAL: Sleep Extension Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Clinical Trial Evaluating Outcomes of Surveyed Zirconia Crowns
Status: NOT_YET_RECRUITING
Conditions: Removable Partial Denture|Dental Crown
Interventions: DEVICE: Surveyed zirconia crown
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Qingpeng Ointment in Treating Shoulder Syndrome During Rehabilitation Period of Cerebral Hemorrhage
Status: UNKNOWN
Conditions: The Efficacy of Qingpeng Ointment
Interventions: DRUG: Qingpeng Ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: DLBCL|High-grade B-cell Lymphoma (HGBCL)|Primary Mediastinal Large B-cell Lymphoma (PMBCL)|FL|MCL|Small Lymphocytic Lymphoma (SLL)|Marginal Zone Lymphoma (MZL)
Interventions: BIOLOGICAL: Epcoritamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT