pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety of A Group A, C Polysaccharide Meningococcal and Type b Haemophilus Influenzal Conjugate Vaccine in Children
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: 0.5ml/dose for a person|BIOLOGICAL: 0.5ml/dose for a person
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation (tDCS) in Pediatric Obsessive Compulsive Disorder (OCD)
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|Pediatric Psychiatric Disorder
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Group Antenatal Care: Effectiveness and Contextual Factors Linked to Implementation Success in Malawi
Status: ACTIVE_NOT_RECRUITING
Conditions: Premature Birth
Interventions: BEHAVIORAL: Antenatal Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Assess LY01005 Versus Goserelin Comparator (ZOLADEX®) in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Cancer of Prostate
Interventions: DRUG: LY01005|DRUG: Zoladex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: US-Guided PECS II Block Versus MTP Block For Postoperative Analgesia Of MRM Sugery
Status: RECRUITING
Conditions: Neuromuscular Blockade|Post Operative Pain|Analgesia|Anesthesia, Local
Interventions: PROCEDURE: PECS II BLOCK|PROCEDURE: MTP BLOCK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Research for the Molecular Imaging of the HER2 Targeting Tracer
Status: RECRUITING
Conditions: HER2 Positive or Suspicious Positive Tumors
Interventions: RADIATION: 68Ga/18F-HER2 Affibody PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 15 Years Outcomes Following Bioprosthetic vs Mechanical Aortic Valve Replacement Between 50-65 Years
Status: COMPLETED
Conditions: Surgery|Survival, Prosthesis|Valve Heart Disease
Interventions: PROCEDURE: bioprosthesis implantation between 2000-2015|PROCEDURE: mechanical prosthesis implantation between 2000-2015
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Glycemic Durability After Metformin Failure
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Glimepiride|DRUG: Vildagliptin|DRUG: Pioglitazone|DRUG: Canagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Interferential Laser Therapy in Pain Reduction in Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Neuropathic Pain
Interventions: DEVICE: Interferential Laser Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-Dose, Bioequivalence Study of FMXIN001 4 mg Microspheres Powder
Status: COMPLETED
Conditions: Opioid Overdose
Interventions: COMBINATION_PRODUCT: Nasus Pharma FMXIN001|COMBINATION_PRODUCT: Nasal Naloxone liquid spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Using Implementation Intentions to Reduce Anger and Aggression in Adolescence
Status: COMPLETED
Conditions: Aggression|Anger
Interventions: BEHAVIORAL: Volitional Help Sheet (VHS)|BEHAVIORAL: Volitional Help Sheet (VHS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Grasping Function After Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injury
Interventions: DEVICE: iTMS|OTHER: Motor Task|DEVICE: Sham iTMS|OTHER: Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rifampin Versus Isoniazid for the Treatment of Latent Tuberculosis Infection in Children (P4v9)
Status: COMPLETED
Conditions: Latent Tuberculosis Infection
Interventions: DRUG: Isoniazid|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: JUVÉDERM® VOLITE™ XC for Cheek Skin Smoothness
Status: COMPLETED
Conditions: Skin Smoothness of the Cheeks
Interventions: DEVICE: JUVÉDERM VOLITE™ XC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Loop Ileostomy Versus Loop Transverse Colostomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Neoplasms|Ostomy|Neoplasms
Interventions: PROCEDURE: Laparoscopic or open low-anterior resection of the rectum with TME and created loop transverse colostomy|PROCEDURE: Laparoscopic or open low-anterior resection of the rectum with TME and created loop ileostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Marketed One-Step Peroxide Lens Care Solution in Symptomatic Contact Lens Wearers
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Hydrogen peroxide-based contact lens solution|DEVICE: Habitual contact lens solution|DEVICE: Habitual contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of a New Technique for Periodontal Pocket Reduction in the Extraction of Wisdom Teeth
Status: RECRUITING
Conditions: Molar, Third|Periodontal Pocket
Interventions: PROCEDURE: "Distal Flap Reduction" Group|PROCEDURE: "Only Exodontia" Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myocardial Infarction|Non-ST Elevation Myocardial Infarction|ST Elevation Myocardial Infarction
Interventions: DRUG: Metoprolol Succinate|DRUG: Bisoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Bioactive Material Versus a Fluoride-Releasing Hybrid Restorative Material in Cervical Lesions
Status: UNKNOWN
Conditions: Dental Caries
Interventions: PROCEDURE: cervical restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy
Status: UNKNOWN
Conditions: Oculomotor Nerve Palsy|Trochlear Nerve Palsy|Abducens Nerve Paralysis
Interventions: OTHER: Ocular acupuncture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Follow-up of a Cohort of Pre-diabetics in the North of France (DiabeNord)
Status: COMPLETED
Conditions: Prediabetes
Interventions: OTHER: Prediabetes screening and prospective follow-up over 5 years
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modulation of Motor Cortex Excitability by TMS and tDCS (MAGS1)
Status: COMPLETED
Conditions: Motor Activity|Motor Neuroplasticity
Interventions: DEVICE: anodal tDCS|DEVICE: cathodal tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Impact of a Coordinating Nurse in a Personalized Care Program on Quality of Care, Coordination of the Actors and on Quality of Life for Patients With Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BEHAVIORAL: EORTC QLQ-C30|BEHAVIORAL: Satisfaction questionnaire - patient|BEHAVIORAL: Satisfaction questionnaire - general practitioner or home nurse|BEHAVIORAL: EORTC QLQ-LC13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Evaluating the Efficacy of Metastasectomy in Patients With Oligo-Metastatic Breast Cancer(OMIT)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: PROCEDURE: Metastasectomy for the metastatic sites
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Engagement of Patients With Advanced Cancer
Status: COMPLETED
Conditions: End of Life|Advanced Cancer|Lung Neoplasm|Gastric Cancer|Colon Cancer|Glioblastoma Multiforme|Head and Neck Neoplasms|Rectum Cancer|Melanoma|Kidney Cancer|Prostate Cancer|Testicular Neoplasms|Liver Cancer|Cancer of Unknown Origin
Interventions: BEHAVIORAL: EPAC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: imPulse™ Una Infrasound-to-ultrasound E-stethoscope
Status: COMPLETED
Conditions: Covid19|COVID-19 Pneumonia|COVID-19 Respiratory Infection|COVID-19 Acute Respiratory Distress Syndrome|Mass Screening|Corona Virus Infection|Vaccine Virus Shedding
Interventions: DEVICE: imPulse™ Una infrasound-to-ultrasound e-stethoscope|DIAGNOSTIC_TEST: (PPA >95%) FDA EUA RT-PCR|RADIATION: HR-CT-scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Polyclonal Tregs for Lupus
Status: TERMINATED
Conditions: Lupus Erythematosus, Cutaneous|Lupus Erythematosus, Discoid|Lupus Erythematosus, Systemic
Interventions: BIOLOGICAL: Ex vivo Expanded Human Autologous Polyclonal Regulatory T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Trial of Ebola Vaccine in Mali
Status: COMPLETED
Conditions: Ebola Virus Disease|Hemorrhagic Fever
Interventions: BIOLOGICAL: Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO Z|BIOLOGICAL: Booster-MVA-BN® Filo or saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Granulocyte Colony Stimulating Factor (G-CSF) for Bone Marrow Transplant (BMT)
Status: COMPLETED
Conditions: Hematologic Diseases|Hematologic Malignancies
Interventions: DRUG: Granulocyte Colony Stimulating Factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Of The Effect Of Rifaximin On B-Cell Dysregulation In Cirrhosis
Status: TERMINATED
Conditions: Liver Cirrhosis|Chronic Hepatitis C
Interventions: DRUG: Rifaximin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Leucine Supplementation and Skeletal Muscle Disuse
Status: COMPLETED
Conditions: Disuse Atrophy
Interventions: DIETARY_SUPPLEMENT: Leucine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Ascending Multiple Dose Study With VTP-43742 in Healthy Volunteers and Psoriatic Patients
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: VTP-43742|DRUG: Placebo 1|DRUG: Placebo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Giving IL-2 Alone to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3 Who Do Not Wish to Receive Anti-HIV Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Anti-Inflammatory Agents on Biological Responses to Endotoxin Inhalation in Healthy Subjects
Status: COMPLETED
Conditions: Innate Immunity
Interventions: DRUG: adalimumab|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vascular and Lipid Effects of Omega-3 Fatty Acids in People With Moderately Elevated Triglycerides
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: 4/day of 4g P-OM3 capsules|DRUG: 4/day of 1g P-OM3 capsules|DRUG: Corn Oil Placebo, 4 capsules/day for 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Microbiome Shift in Peri-mucositis by Anti-inflammatory Drugs
Status: UNKNOWN
Conditions: Peri-implant Mucositis
Interventions: DRUG: Flurbiprofen|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Role of Screening With Coronary Computed Tomography Angiography in Primary Prevention of Coronary Heart Disease
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Primary Prevention Strategy
Interventions: DIAGNOSTIC_TEST: Coronary Computed Tomography Angiography|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy Subjects to Evaluate Pharmacokinetics and Food Effect After Dosing of GS-248
Status: COMPLETED
Conditions: Pharmacokinetic
Interventions: DRUG: Formulation A GS-248|DRUG: Formulation B GS-248
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety And Immunogenicity Of Novel Candidate Blood-Stage Malaria Vaccine P27A : Phase Ia/Ib
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: CH-Alum50|BIOLOGICAL: CH-GLA2.5/50|BIOLOGICAL: TZ Ver|BIOLOGICAL: TZ Alum 50|BIOLOGICAL: TZ GLA 2.5/10|BIOLOGICAL: TZ GLA5/50|BIOLOGICAL: TZ GLA2.5/50
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E
Status: UNKNOWN
Conditions: Viral Gastroenteritis Due to Rotavirus
Interventions: BIOLOGICAL: ORV 116E|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mindfulness-based Educational Intervention on Anxiety, Depression, Stress and Quality of Life on Menopausal Woman
Status: RECRUITING
Conditions: Menopause
Interventions: BEHAVIORAL: mindfulness-based educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gossypol Combined With Docetaxel and Cisplatin Scheme in Advanced Non Small-cell Lung Cancers With APE1 High Expression
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Gossypol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis
Status: COMPLETED
Conditions: Recurrent Aphthous Stomatitis
Interventions: OTHER: sodium lauryl sulfate|OTHER: sodium lauryl sulfate|OTHER: sodium lauryl sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Lapatinib and Radiation Therapy in Treating Patients With Locally Recurrent or Chemotherapy-Refractory Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: lapatinib ditosylate|GENETIC: TdT-mediated dUTP nick end labeling assay|GENETIC: gene expression analysis|GENETIC: microarray analysis|OTHER: immunohistochemistry staining method|PROCEDURE: biopsy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bendamustine Hydrochloride, Clofarabine, and Etoposide in Treating Younger Patients With Relapsed or Refractory Hematologic Malignancies
Status: COMPLETED
Conditions: Hodgkin Lymphoma|Non-Hodgkin Lymphoma|Acute Leukemia
Interventions: DRUG: Bendamustine|DRUG: Clofarabine|DRUG: Etoposide|DRUG: Etoposide phosphate|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temporary Artery Clipping for Robotically-assisted Myomectomy, a Multicentric Randomized Controlled Trial
Status: RECRUITING
Conditions: Fibroid Uterus
Interventions: PROCEDURE: Temporary clipping of the uterine arteries and the utero-ovarian ligmants.|PROCEDURE: No temporary clipping of the uterine arteries and the utero-ovarian ligmants.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vemurafenib and Panitumumab Combination Therapy in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: combination panitumumab and vemurafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Single- and Multiple-doses of Aripiprazole in Adult Subjects With Schizophrenia or Bipolar I Disorder
Status: COMPLETED
Conditions: Schizophrenia|Bipolar I Disorder
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the Impact of the Use of Hypnotherapy Performed by a Virtual Reality Toolalong the Care Pathway of Patients Undergoing Breast Cancer Treatment.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DEVICE: Oncomfort® clinical virtual reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pembrolizumab With Locally Delivered Radiation Therapy for the Treatment of Metastatic Esophageal Cancers
Status: COMPLETED
Conditions: Esophageal Neoplasms|Esophageal Cancer|Cancer of the Esophagus
Interventions: DRUG: Pembrolizumab|RADIATION: Brachytherapy|PROCEDURE: Endoscopic biopsy|PROCEDURE: Computed tomography-guided biopsy|PROCEDURE: Peripheral blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Analgesics, Opioid|Analgesics, Non-Narcotic|Physiological Effects of Drugs|Peripheral Nervous System Agents|Patient Satisfaction|Return to Work|Activity, Sexual
Interventions: DRUG: Abdominal wall block with liposomal bupivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Pterygopalatine Ganglion Block Based Multimodal Anesthesia for Tonsillectomy Operations
Status: COMPLETED
Conditions: PREVENTION OF POSTTONSILLECTOMY PAIN|DECREASE POSTTONSILLECTOMY NAUSEA AND VOMITTING|DECREASE POSTOPERATIVE HOSPITAL STAY
Interventions: PROCEDURE: opioid based multimodal anesthesia|PROCEDURE: pterygopalatine ganglion block based multimodal anesthesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pain Management Associated With the Insertion of Jaydess® in Nulliparous Women
Status: UNKNOWN
Conditions: IUD Insertion Complication
Interventions: DRUG: Tramadol|BEHAVIORAL: Verbal anesthesia|DEVICE: Jaydess
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Evaluate the Benefits of Using a Range of Wound Care Products From a Single Manufacturer
Status: TERMINATED
Conditions: Wound - in Medical Care
Interventions: OTHER: Use of wound care products from a single manufacturer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Citalopram in Treating Postmenopausal Women With Hot Flashes
Status: COMPLETED
Conditions: Breast Cancer|Hot Flashes|Psychosocial Effects of Cancer and Its Treatment
Interventions: DRUG: citalopram hydrobromide|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Intraoperative Paravertebral Block on Postoperative Pain and Recovery in Patients Undergoing Mechanical Correction for Scoliosis
Status: COMPLETED
Conditions: Scoliosis
Interventions: PROCEDURE: Paravertebral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Anti-reflux Effect of Double-flap Technique in Laparoscopic Proximal Gastrectomy.
Status: NOT_YET_RECRUITING
Conditions: Proximal Early Gastric Cancer
Interventions: PROCEDURE: double-flap technique（DFT）; double-tract reconstruction(DTR),
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sirolimus-coated Coronary Balloon Dilatation Catheter for Coronary Small Vessels
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: Sirolimus-coated Coronary Balloon Dilatation Catheter|DEVICE: Drug-coated Coronary Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE)
Status: COMPLETED
Conditions: Eosinophilic Esophagitis (EoE)
Interventions: DRUG: Oral Budesonide Suspension (OBS)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of End-Effector Robot-Assisted Gait Training in Subacute Stroke Patients
Status: COMPLETED
Conditions: Severe Stroke|Acute Stroke|Mild Stroke|Central Nervous System Diseases|Cerebrovascular Disease|Brain Diseases|Cardiovascular Diseases|Gait, Hemiplegic
Interventions: DEVICE: Robot-Assisted Gait Training (RAGT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of CCM in HF With Higher Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure|Heart Failure With Preserved Ejection Fraction|Heart Failure With Mid Range Ejection Fraction|Heart Failure With Moderately Reduced Ejection Fraction|Diastolic Heart Failure
Interventions: DEVICE: Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System|DEVICE: OPTIMIZER™ Smart Mini System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of TPM502 in Adults With Celiac Disease
Status: RECRUITING
Conditions: Celiac Disease
Interventions: DRUG: TPM502|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study Utilizing Yondelis and Doxorubicin in Patients With a Type of Cancer Called Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma|Sarcoma|Neoplasms, Connective and Soft Tissue|Neoplasms by Histologic Type|Neoplasms
Interventions: DRUG: Doxorubicin|DRUG: Trabectedin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-cycle Remote Ischemic Preconditioning and Postconditioning (SCRIP) Trial
Status: UNKNOWN
Conditions: Ischemic Reperfusion Injury
Interventions: PROCEDURE: RIPre|PROCEDURE: Sham-Pre|PROCEDURE: RIPost|PROCEDURE: Sham-Post
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Self-management Intervention for Adult Patients With Hearing Difficulties to Promote Hearing Aid Use and Benefit
Status: COMPLETED
Conditions: Written Information|Written Info and Hearing Aid Reminder|Written Info and Planning on Hearing Aid Use|All Materials
Interventions: OTHER: ii) the reminder|OTHER: ii) written behavioural plan|OTHER: iv) all materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: LIpid Lowering With Highly Potent Statins in Hyperlipidaemia With Type 2 Diabetes patiENts
Status: COMPLETED
Conditions: Hypercholesterolemia With Concomitant Type 2 Diabetes
Interventions: DRUG: Atorvastatin|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Secukinumab in Subjects With Moderate to Severe Chronic Plaque-type Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Secukinumab 150 mg s.c.|DRUG: Secukinumab 300 mg s.c.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Single Ultra-Processed Meal on Myocardial Endothelial Function Assessed With Positron Emission Tomography
Status: COMPLETED
Conditions: Myocardial Endothelial Function
Interventions: OTHER: NOVA4 meal|OTHER: NOVA1-3 meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Management of Miller Class I & II Gingival Recession
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: PROCEDURE: coronally advanced flap with abrasive de-epithelized graft.|PROCEDURE: coronally advanced flap with de-epithelized graft.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL)
Status: COMPLETED
Conditions: Human Immunodeficiency Virus Infection
Interventions: DRUG: lopinavir/ritonavir (LPV/r)|DRUG: emtricitabine/tenofovir disoproxil fumarate (FTC/TDF)|DRUG: raltegravir (RAL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aggressive Cholesterol Therapy to Inhibit Vein Graft Events After CABG (ACTIVE Trial)
Status: COMPLETED
Conditions: Saphenous Vein Graft Disease
Interventions: DRUG: Atorvastatin 80 mg daily|DRUG: Atorvastatin 10 mg daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Pamiparib in Newly Diagnosed and rGBM
Status: RECRUITING
Conditions: Glioblastoma|Glioblastoma Multiforme|Glioblastoma Multiforme, Adult
Interventions: DRUG: Pamiparib|DRUG: Olaparib|RADIATION: Radiation therapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wolffia Globosa (Mankai) and Glycemic Control Among Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Mankai beverage|OTHER: Water (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACT-777991 (SAD)|DRUG: ACT-777991 (MAD)|DRUG: Placebo (SAD)|DRUG: Placebo (MAD)|DRUG: 14C-ACT-777991 microtracer (SAD - Absolute Bioavailability)|DRUG: Microtracer matching placebo (SAD - Absolute Bioavailability)|DRUG: 14C-ACT-777991 microtracer (MAD - ADME)|DRUG: Microtracer matching placebo (MAD - ADME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Goal of This Study is to Evaluate the Effect of Ultrasound Guided Erector Spinae Plane Block on Postoperative Pain After Major Abdominal Surgeries
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Erector spinae plane block|DEVICE: Intravenous meperidine patient controlled analgesia device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Microsatellite Stable Metastatic Colorectal Cancer
Interventions: DRUG: Evorpacept (ALX148)|DRUG: Cetuximab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Rehabilitation and FES for Hand Functionality in Persons With Cervical Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury at C5-C7 Level
Interventions: OTHER: FES+CBA|OTHER: FES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Alogliptin Used Combination With Metformin in Participants With Type 2 Diabetes in Japan
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Alogliptin and metformin|DRUG: Alogliptin and metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Symbicort Onset of Action 2
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: budesonide/formoterol|DRUG: fluticasone/salmeterol|DRUG: albuterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan Medoxomil Low-dose|DRUG: Losartan|DRUG: Placebo for Azilsartan Medoxomil|DRUG: Placebo for Losartan|DRUG: antihypertension medication - Add-on Therapy|DRUG: Azilsartan Medoxomil Medium-dose|DRUG: Azilsartan Medoxomil High-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Single Doses of BLI-489 in Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BLI-489|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ThromboEmbolism Prevention Efficacy and Safety Trial (TEMPEST)
Status: COMPLETED
Conditions: Arthroplasty
Interventions: DRUG: SB-424323|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: TTK peptide mixed with Montanide ISA 51
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrosurgery Wars;Ligasure or Enseal in Total Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Task Performance
Interventions: DEVICE: Ligasure device|DEVICE: Articulating Enseal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: Itraconazole|OTHER: Placebo|DRUG: Risdiplam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Investigate the Efficacy and Safety of FE 999302 as add-on Treatment to Follitropin Delta (REKOVELLE) in Women Undergoing Controlled Ovarian Stimulation.
Status: COMPLETED
Conditions: Controlled Ovarian Stimulation
Interventions: DRUG: FE 999302 (1 μg) and follitropin delta|DRUG: FE 999302 (2 μg) and follitropin delta|DRUG: FE 999302 (4 μg) and follitropin delta|DRUG: FE 999302 (8 μg) and follitropin delta|DRUG: FE 999302 (12 μg) and follitropin delta|OTHER: Placebo and follitropin delta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trans-obturator Mid-urethral Sling and the Single-incision Sling in Women With Stress Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence, Stress
Interventions: DEVICE: TOT - inside-out trans-obturator tape/sling|DEVICE: SIS - Innovative fixation single incision sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NOLAN: Naproxen or Loratadine and Neulasta
Status: COMPLETED
Conditions: Bone Pain in Stage I - III Breast Cancer
Interventions: DRUG: Naproxen|DRUG: Loratadine|BIOLOGICAL: Pegfilgrastim|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase-II Trial of Induction Chemotherapy and Chemoradiotherapy Plus/Minus Durvalumab and Consolidation Immunotherapy in Patients With Resectable Stage III NSCLC.
Status: RECRUITING
Conditions: NSCLC, Stage III
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Remote Monitoring Smartphone Application and Care Model of COVID-19 Patients in the Community (ReCOVER)
Status: UNKNOWN
Conditions: COVID
Interventions: DEVICE: TCC-COVID mHealth solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Corneal Flap Transplantation for Macular Hole Repair of High Myopia
Status: ACTIVE_NOT_RECRUITING
Conditions: Retinal Perforations|Myopia, Degenerative
Interventions: PROCEDURE: corneal flap transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetogenicity of Cyclosporine and Tacrolimus
Status: COMPLETED
Conditions: Complications of Transplanted Organs and Tissue|Diabetes Mellitus Nos New Onset
Interventions: DRUG: cyclosporine|DRUG: tacrolimus|OTHER: Capsules and isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GrafixCORE®: Open-Label Study to Evaluate the Safety and Efficacy of GrafixCORE® for Complex Diabetic Foot Wounds
Status: COMPLETED
Conditions: Complex Diabetic Foot Wounds
Interventions: OTHER: Grafix®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cysts.
Status: UNKNOWN
Conditions: Ovarian Endometrioma|Ovary Cyst
Interventions: PROCEDURE: The impact of electrocoagulation on ovarian reserve after laparoscopic excision of ovarian cysts:
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Imatinib Mesylate and the Pharmacokinetics of Acetaminophen/Paracetamol in Patients With Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP)
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia (CML)
Interventions: DRUG: Imatinib/Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Compound K11T e K11TMax in ASD
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DIETARY_SUPPLEMENT: Inflammatory level|DIETARY_SUPPLEMENT: Cognitive assessment|DIETARY_SUPPLEMENT: Pedagogical assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Volume Status by Bedside Ultrasound in Children With Acute Gastroenteritis
Status: COMPLETED
Conditions: Dehydration|Acute Gastroenteritis
Interventions: DEVICE: Measurement of inferior vena cava diameters with ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Focal Laser Ablation of Prostate Cancer: A Feasibility Study Using MRI/US Image Fusion for Guidance
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: Focal Laser Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a New High-protein Oral Supplement on Functional Parameters in Patients in Nursing Homes
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: New DELICAL formula|DIETARY_SUPPLEMENT: Standard DELICAL formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
Status: RECRUITING
Conditions: Suicide, Attempted|Suicide and Depression|Suicide Threat
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Midazolam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Intravenous recombinant tissue plasminogen activator (rtPA) Alteplase|DRUG: Intravenous Tenecteplase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindful Movement for Physical Activity and Wellbeing in Older Adults
Status: COMPLETED
Conditions: Physical Inactivity
Interventions: OTHER: Mindful Movement|OTHER: 10 Keys to Health & Wellbeing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of an Office-based Limited Facelift and Hospital-based Full Facelift
Status: UNKNOWN
Conditions: Skin Aging|Facial Asymmetry|Aging Problems
Interventions: PROCEDURE: Limited facelift|PROCEDURE: Full facelift|OTHER: FACE-Q | Aesthetics - Satisfaction With Lower Face and Jawline|OTHER: FACE-Q | Aesthetics - Recovery Early Symptoms|OTHER: FACE-Q | Aesthetics - Satisfaction with Outcome|OTHER: FACE-Q | Aesthetics - Adverse Effects: Cheeks, Lower Face, Neck
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Impact of Liquid Biopsy Genomic Profiling on Treatment Patients With Metastatic Prostate Cancer in Spain (SOLTI-2102)
Status: RECRUITING
Conditions: Metastatic Prostate Cancer
Interventions: GENETIC: Liquid Biopsy|GENETIC: Archival Tumor DNA sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Plerixafor/G-CSF as Additional Agents for Conditioning Before TCR Alpha/Beta Depleted HSCT in WAS Patients
Status: UNKNOWN
Conditions: Wiskott-Aldrich Syndrome|Hematopoietic Stem Cell Transplantation|Graft Failure
Interventions: BIOLOGICAL: G-CSF for Conditioning before HSCT.|BIOLOGICAL: Plerixafor for Conditioning before HSCT.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Severe Chronic Heart Failure
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: DIETARY_SUPPLEMENT: Omacor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: Repotrectinib|DRUG: Voriconazole|DRUG: Quinidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate Cancer
Status: RECRUITING
Conditions: Oligometastatic Disease|Prostatic Cancer, Castration-Resistant
Interventions: RADIATION: local ablative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Prednisolone|DRUG: Daunorubicin|DRUG: Vincristine|DRUG: L-Asparaginase|DRUG: Cyclophosphamide|DRUG: Methotrexate|DRUG: Cytosine Arabinoside
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Manging Post Spinal Hypotension During Elective Cesarean Section
Status: COMPLETED
Conditions: Hypotension
Interventions: DRUG: Adrenaline|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Docetaxel With or Without TAK-117 (MLN1117) in Participants With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Docetaxel|DRUG: TAK-117
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Premature Ovarian Failure (POF)
Status: UNKNOWN
Conditions: Premature Ovarian Failure
Interventions: BIOLOGICAL: Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hematopoietic Stem Cell Transplant for Recurrent Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: RADIATION: 131Iodine-Anti-B1 Radioimmunotherapy|DRUG: BEAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT