pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pamiparib Plus Surufatinib in Patients With Platinum-resistant Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Ovarian Carcinoma|Platinum-resistant Ovarian Cancer|Fallopian Tube Carcinosarcoma|Primary Peritoneal Cancer
Interventions: DRUG: Pamiparib|DRUG: Surufatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Endoscopic Gastrostomy Before Definitive Concurrent Chemoradiation Therapy for Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: COMBINATION_PRODUCT: Concurrent chemoradiotherapy combined with enteral feeding by percutaneous endoscopic gastrostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human, Study of MATTISSE® Tissue Engineering Chamber in Adult Female Patients Undergoing Breast Reconstruction After Mastectomy for Cancer
Status: RECRUITING
Conditions: Breast Cancer Female|Breast Cancer Prevent|Breast Reconstruction
Interventions: DEVICE: MATTISSE TEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Single-Arm Trial of Neurovascular Drug-Eluting Balloon Dilatation Catheter Treating Symptomatic Intracranial Atherosclerotic Stenosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Atherosclerosis
Interventions: DEVICE: Neurovascular Drug-Eluting Balloon Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lidocaine for Cystectomy Procedures
Status: COMPLETED
Conditions: Invasive Bladder Cancer
Interventions: PROCEDURE: Cystectomy|DRUG: Lidocaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neoadjuvant Enoblituzumab (MGA271) in Men With Localized Intermediate and High-Risk Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Enoblituzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Sleep Disturbance
Interventions: OTHER: Post-Illumination Pupillary Response (PIPR)|OTHER: Polysomnography|OTHER: Multiple Sleep Latency Test|BEHAVIORAL: Ecological Momentary Assessments|DEVICE: Actigraphy|OTHER: DLMO|OTHER: Melatonin Suppression Test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effectiveness of Armodafinil to Treat Cancer-Related Fatigue in Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Fatigue|Multiple Myeloma
Interventions: DRUG: armodafinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevena to Prevent Surgical Site Infection After Emergency Abdominal Laparotomy
Status: NOT_YET_RECRUITING
Conditions: Surgical Site Infection|Length of Stay|Seroma|Hematoma
Interventions: DEVICE: Closed incision negative pressure therapy versus standard dressing after emergency abdominal laparotomies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phentolamine Versus Magnesium Sulphate Infusion During Elective Lumbar Spine Surgery: a Randomized Double Blind Comparative Study
Status: UNKNOWN
Conditions: Mean Blood Pressure
Interventions: OTHER: MAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Direct Resuscitation of the Open Peritoneum
Status: SUSPENDED
Conditions: Wound; Abdomen|Abdomen, Acute|Wound Surgical
Interventions: DEVICE: Abthera™ Open Abdomen Negative Pressure Therapy Device System|DRUG: Dianeal PD-2 with 2.5% Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: NAVA|OTHER: Expiratory trigger (ET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Statin Therapy in Heart Failure: Potential Mechanisms of Benefit
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: atorvastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Phase II Study of BAY 43-9006 in Chronic Myelogenous Leukemia (CML) Patients Resistant to Gleevec
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Nexavar (Sorafenib, BAY43-9006)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WeanINg From Mechanical Ventilation for ARDS CovId-19 Patients Guided by Combined Thoracic UltraSound.
Status: COMPLETED
Conditions: COVID-19|ARDS, Human|Mechanical Ventilation
Interventions: DIAGNOSTIC_TEST: CTUS examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study Investigating the Feasibility of the Saebo Arm Training Program on an Inpatient Population
Status: COMPLETED
Conditions: Stroke|Hemiplegia
Interventions: DEVICE: SaeboFlex Dynamic Hand Orthosis|PROCEDURE: Saebo F.T.M. Arm Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Investigate the Safety, Efficacy, Pharmacokinetics and Bioavailability of HTX-011, HTX-002, or HTX-009 Administered Via Injection and/or Topical Application Following Unilateral Open Inguinal Herniorrhaphy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: HTX-011|DRUG: Placebo|DRUG: HTX-002|DRUG: Bupivacaine HCI (Marcaine)|DRUG: HTX-011A|DRUG: HTX-011B|DRUG: HTX-009
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir, Daclatasvir, Ribavirin for Hepatitis C Virus (HCV) Cirrhotics
Status: COMPLETED
Conditions: Hepatitis C|Cirrhosis
Interventions: DRUG: Sofosbuvir|DRUG: Daclatasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fulvestrant (F)+Placebo vs F+Palbociclib First Line for Postmenopausal Hormone Receptor+ Advanced Breast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms
Interventions: DRUG: PD-0332991 (Palbociclib)|DRUG: Fulvestrant|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magrolimab in Combination With Azacitidine After Allogeneic HCTin Treating Patients With High-Risk AML or MDS
Status: SUSPENDED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Azacitidine|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspirate|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Echocardiography|BIOLOGICAL: Magrolimab|PROCEDURE: Multigated Acquisition Scan|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY2875358 in Participants With Non-Small Cell Lung Cancer With Activating Epidermal Growth Factor Receptor Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: LY2875358|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of D4064A Administered to Patients With Recurrent or Persistent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Status: SUSPENDED
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cancer
Interventions: DRUG: D4064A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study for the Treatment of Chronic Idiopathic Urticaria With High Doses of AERIUS (Desloratadine) (Study P04849)
Status: COMPLETED
Conditions: Chronic Idiopathic Urticaria
Interventions: DRUG: 5-mg Desloratadine|DRUG: 10-mg Desloratadine|DRUG: 20-mg Desloratadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Perception With a Comfort-ın Jet Injection and Conventional Dental Injection
Status: COMPLETED
Conditions: Pain|Local Infiltration|Anesthesia|Fear|Anxiety|Needle Phobia
Interventions: BEHAVIORAL: Needle-free injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin
Status: COMPLETED
Conditions: Labor|Induction|PROM (Pregnancy)
Interventions: DRUG: SYNPITAN FORT 5 IU|DRUG: Propess,SYNPITAN FORT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Breather Trainer Versus Pulmonary Rehabilitation on Cardiopulmonary Efficiency
Status: UNKNOWN
Conditions: COVID-19|COPD
Interventions: OTHER: The breather respiratory muscle trainer|OTHER: Diaphragmatic and localized breathing exercises|OTHER: interval aerobic training and respiratory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Passive Vertebral Mobilization and Propriocemptive Neuromuscular Techniques in Mechanical Neck Pain
Status: COMPLETED
Conditions: Mechanical Neck Pain
Interventions: OTHER: Passive Vertebral Mobilization|OTHER: PNF exercise|OTHER: Routine Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Perioperative Pregabalin for Post-Craniotomy Pain
Status: WITHDRAWN
Conditions: Chronic Postoperative Pain|Headache
Interventions: DRUG: Pregabalin|DRUG: pregabalin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study to Assess the Early Use of Porcine Cross-linked Collagen Paste in Cryptoglandular Anorectal Fistulas
Status: TERMINATED
Conditions: Anorectal Abscess|Fistula in Ano
Interventions: BIOLOGICAL: Collagen paste
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Pimasertib in Hematological Malignancies
Status: TERMINATED
Conditions: Leukemia, Myeloid, Acute|Hematologic Neoplasms
Interventions: DRUG: Pimasertib|DRUG: Pimasertib|DRUG: Pimasertib|DRUG: Pimasertib|DRUG: Pimasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aim 3, Optimizing CRC Screening in Patients With Diabetes in Safety-net Primary Care Settings
Status: RECRUITING
Conditions: Colorectal Cancer Screening|Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Targeted CRC Screening Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Lapaquistat Acetate in Subjects Currently Treated With Lipid-Lowering Therapy.
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Lapaquistat acetate and lipid-lowering therapy|DRUG: Lipid-lowering therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine for Thoracotomy
Status: COMPLETED
Conditions: Thoracic Diseases
Interventions: DRUG: Bupivacaine Hcl 0.25% Inj|DRUG: Saline Solution for Block|DRUG: Saline Solution intravenously|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Unsustained Tachycardia Trial (MUSTT)
Status: COMPLETED
Conditions: Arrhythmia|Cardiovascular Diseases|Coronary Disease|Death, Sudden, Cardiac|Heart Diseases|Myocardial Ischemia|Tachycardia, Ventricular
Interventions: PROCEDURE: electrophysiology|DRUG: anti-arrhythmia agents|DEVICE: defibrillators, implantable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trigeminal Brainstem Mapping 2: Higher Cortical Strucureas as Well as Subnuclei of the Spinal Trigeminal Nucleus
Status: RECRUITING
Conditions: Trigeminal Pain, Headache Disorders, Migraine
Interventions: DEVICE: Electric Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery.
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ultrasound-Assisted Paravertebral Block v. Traditional Paravertebral Block For Pain Control
Status: COMPLETED
Conditions: Paravertebral Peripheral Nerve Block|Acute Pain Management
Interventions: PROCEDURE: Thoracotomy|PROCEDURE: Video-Assisted Thoracoscopic Surgery (VATS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance
Status: COMPLETED
Conditions: Sleep Bruxism|Tension Headache|Migraine Headache
Interventions: DEVICE: The Luco Hybrid OSA Appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Automatic Self Transcending Meditation (ASTM) Versus Usual Care in Patients With Glaucoma
Status: UNKNOWN
Conditions: Glaucoma|Depression|Anxiety|Quality of Life
Interventions: OTHER: Automatic Self Transcending Meditation|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Compensation for Blindness With the Intelligent Retinal Implant System (IRIS V2) in Patients With Retinal Dystrophy
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Cone Rod Dystrophy|Choroideremia
Interventions: DEVICE: Intelligent Retinal Implant System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study on the Evaluation of the Effectiveness of a Virtual Reality Device on Anxiety During Procedural Sedation in Traumatology in Emergency Department
Status: COMPLETED
Conditions: Reality Device|Reduction Procedure|Fracture|Dislocation
Interventions: DEVICE: Experimental : Virtual reality + analgesia-sedation|DRUG: Control: Analgesia-sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Granexin® Gel for the Reduction of Scar Formation in Surgical Wounds Following Bilateral Anchor Incision Breast Surgery
Status: COMPLETED
Conditions: Mammoplasty|Scarring|Scar|Breast Reconstruction
Interventions: DRUG: Granexin® gel 100 μM|DRUG: Granexin® gel 200 μM|DRUG: Vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction With the Management of a Stopped Pregnancy in the First Trimester
Status: COMPLETED
Conditions: Pregnancy Loss, Early
Interventions: DRUG: Medical treatment with Mifégyne® and MisoOne®|PROCEDURE: Endo-uterine aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome
Status: COMPLETED
Conditions: Activated PI3K-delta Syndrome|Immunodeficiency Primary
Interventions: DRUG: Rapamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Hypoxia Imaging and Intensity Modulated Radiotherapy for Inoperable Non-small-cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: OTHER: Multimodal hypoxia imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing
Status: RECRUITING
Conditions: Leukemia|Acute Myeloid Leukemia in Remission|Myelodysplasia|Acute Lymphoblastic Leukemia in Remission|Chronic Myelogenous Leukemia - Chronic Phase|Chronic Myelogenous Leukemia, Accelerated Phase|Chronic Myelogenous Leukemia With Crisis of Blast Cells|Biphenotypic Acute Leukemia|Lymphoblastic Lymphoma|Burkitt Lymphoma|Burkitt Leukemia|Lymphoma After Relapse|Other Malignant Hematologic Diseases in Remission
Interventions: DEVICE: Magnetic-Activated Cell Sorter (CliniMACS, Miltenyi)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of High Intraoperative Fraction of Inspired Oxygen in Preventing Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting|Laparoscopic Cholecystectomy
Interventions: PROCEDURE: intraoperative Fraction of Inspired Oxygen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of a RAGT & BWSTT on Children With CP
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: Robotic assisted gait training|DEVICE: Body weight supported treadmill training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy
Status: RECRUITING
Conditions: Leprosy
Interventions: DRUG: BE-PEP Bedaquiline|DRUG: SDR-PEP Rifampicin|DRUG: BE-PEP Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ACAR Brain Health Intervention Study
Status: UNKNOWN
Conditions: Aging Well
Interventions: BEHAVIORAL: TBH Brain Workout 1.0|BEHAVIORAL: Brain Health Book Club|BEHAVIORAL: TBH Brain Workout 2.0|BEHAVIORAL: TBH Memory 1.0|BEHAVIORAL: TBH Memory 2.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Safety, Tolerability, and Immunogenicity of a Prime-Boost Regimen of HIV-1 Nef/Tat/Vif, Env pDNA Vaccine Delivered Intramuscularly With Electroporation and HIV-1 rVSV envC Vaccine in Healthy, HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIV-1 nef/tat/vif, env pDNA vaccine|BIOLOGICAL: rVSV HIV envC vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Guided Bilateral Erector Spinae Plane Block Versus Tumescent Anesthesia
Status: COMPLETED
Conditions: Breast Hypertrophy|Pain, Postoperative
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Tumescent Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of Two Forms of Saquinavir Combined With Other Anti-HIV Drugs in HIV-Infected Infants and Children
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Nelfinavir mesylate|DRUG: Saquinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: BIOLOGICAL: Flucelvax|BIOLOGICAL: Fluvirin|BIOLOGICAL: Fluzone High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study to Evaluate the Efficacy and Tolerability of an Anti-inflammatory/Antibiotic Treatment Following Ocular Cataract Extraction
Status: COMPLETED
Conditions: Cataract Extraction|Cataract
Interventions: DRUG: NETILDEX™ ophthalmic gel|DRUG: NETILDEX™ eye drops solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label PK Study of Iron Isomaltoside 1000 (Monofer) Administered by 500 mg IV Injection or 1000 mg IV Infusion to Patients With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: DRUG: Monofer (iron isomaltoside 1000)|DRUG: Monofer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F] FDOPA PET Imaging in Glioma: Feasibility Study for PET Guided Brain Biopsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioma
Interventions: DIAGNOSTIC_TEST: Fluorodopa PET tracer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Probiotic Streptococci and pH-rising Components on the Oral Microbial Flora
Status: COMPLETED
Conditions: Hyposalivation
Interventions: DIETARY_SUPPLEMENT: Test group, probiotic tablets and gel|DIETARY_SUPPLEMENT: Placebo group, placebo tablets and gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Factors for Survival in Patients With Cholangiocarcinoma
Status: RECRUITING
Conditions: Cholangiocarcinoma
Interventions: PROCEDURE: Resection/Ablation of tumor|PROCEDURE: Palliative chemotherapy|PROCEDURE: Neoadjuvant chemotherapy|PROCEDURE: Stereotatic radiotherapy|PROCEDURE: Best supportive care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cardiopulmonary Outcomes and Household Air Pollution Trial
Status: COMPLETED
Conditions: Blood Pressure|Carotid Intima Media Thickness|Endothelial Function|Signs and Symptoms, Respiratory|Respiratory Function Tests
Interventions: DEVICE: Three-burner LPG stove|OTHER: Delivery of LPG tanks|OTHER: Vouchers for LPG tanks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Seroquel®, quetiapine fumarate (atypical antipsychotic)|DRUG: lithium (mood stabilizer)|DRUG: divalproex (mood stabilizer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: HIV Vaccine Trial in Thai Adults
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: ALVAC-HIV vCP1521 + AIDSVAX|OTHER: ALVAC Placebo + AIDSVAX Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Infliximab for Treatment Resistant Major Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Infliximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of ICL670 vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions
Status: COMPLETED
Conditions: Anemia, Sickle Cell
Interventions: DRUG: ICL670, deferoxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: PBRT|RADIATION: PLNRT|DRUG: AA|DRUG: LHRH agonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 6-fluoro-[18F]-L-dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography (PET) and Multiparametric Resonance Magnetic Imagery (RMI) in Initial Exploration of Glial Tumors
Status: COMPLETED
Conditions: Brain Neoplasms|Adult Brain Tumor
Interventions: DIAGNOSTIC_TEST: PET imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Supplementation Trial on Arginine With Metabolic Profiling
Status: COMPLETED
Conditions: Protein|Amino Acid|Arginine
Interventions: DIETARY_SUPPLEMENT: Arginine Drink|DIETARY_SUPPLEMENT: Plain Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Wearable and Patient-reported Outcome-based Continuous Assessment and Support Alerts in Palliative Care
Status: COMPLETED
Conditions: Palliative Care|Wearable Electronic Devices|Patient Reported Outcome Measures|Cancer|Caregiver|Digital Health
Interventions: DEVICE: Garmin VivoSmart 4|DEVICE: mema - ilumivu
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: DAILIES® AquaComfort Plus® Multifocal (MF) - Comparative Assessment of Visual Performance
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: DACP MF|DEVICE: PROCLEAR 1D MF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Glycemic Index (GI) Values in 7 Food Products
Status: COMPLETED
Conditions: Glycemic Index
Interventions: OTHER: Low GI Standard Breakfast|OTHER: Medium GI Standard Breakfast|OTHER: Enfamama A+|OTHER: Glucerna Triple Care|OTHER: Dumex Precima|OTHER: Diasip|OTHER: Test product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure
Status: COMPLETED
Conditions: Acute-On-Chronic Liver Failure
Interventions: DRUG: G-CSF|OTHER: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCG Biosensor and Non- and Invasive Monitoring During Emergency Medicine Cases, a Prospective Feasibility Study
Status: COMPLETED
Conditions: Cardiac Arrest, Out-Of-Hospital|Hypotension and Shock
Interventions: DEVICE: LUCAS 2 Active Decompression 2|OTHER: Hypotension|OTHER: Intensive care transport
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infinnium-Core™ Registry for the Treatment of Patients With De Novo Coronary Lesions
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Infinnium-Core™ Paclitaxel eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of FTX-6058
Status: RECRUITING
Conditions: Sickle Cell Disease|Sickle Cell Anemia
Interventions: DRUG: FTX-6058 oral capsule(s)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Shared Decision-making Training for Inpatients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizo-affective Disorder
Interventions: BEHAVIORAL: shared decision making training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Personalized Caries Management Versus Standard of Care for Preventing Incidence of Caries in Young Egyptian Adults
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Personalized Treatment|OTHER: Chlorhexidine and Remineralization|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Linagliptin as Add on to Basal Insulin in the Elderly
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: placebo|DRUG: linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drink Milk Consumption Benefits With Culture Probiotic in the Treatment of Constipation
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Milk drink with probiotic culture|DIETARY_SUPPLEMENT: Milk drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of MBP-426 in Patients With Second Line Gastric, Gastroesophageal, or Esophageal Adenocarcinoma
Status: UNKNOWN
Conditions: Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma|Esophageal Adenocarcinoma
Interventions: DRUG: MBP-426/Leucovorin/5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moderate Intensity Functional Training as Adjuvant Treatment in Patients With Peripheral Arterial Disease
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Intermittent Claudication
Interventions: OTHER: Supervised exercise therapy: intermittent treadmill walking exercise and moderate intensity functional training|OTHER: Supervised exercise therapy: intermittent treadmill walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Timing of Physical Activity in Cancer Treatment
Status: COMPLETED
Conditions: Metabolic Syndrome|Vascular Disorders|Cardiovascular Risk Factors|Fatigue
Interventions: OTHER: A tailored physical activity program during chemotherapy|OTHER: A tailored physical activity program after chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Hand Exercises on Upper Limb Volume, Quality of Life, and Hand Function in Breast Cancer Survivors
Status: RECRUITING
Conditions: Breast Cancer Lymphedema
Interventions: OTHER: Hand Mobility and Grip Strengthening Exercises|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: "Concentrated Exposure Treatment" (cET) for for Obsessive Compulsive Disorder
Status: UNKNOWN
Conditions: Obsessive Compulsive Disorder (OCD)
Interventions: BEHAVIORAL: Concentrated exposure treatment (cET)|BEHAVIORAL: Self-help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Local Insulin on Varicose Ulcers for Wound Healing
Status: COMPLETED
Conditions: Chronic Venous Disease|Varicose Ulcer|Wound Healing|Insulin|Angiogenesis
Interventions: DRUG: Insulin Glargine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PEG-rhG-CSF Injection for Neutrophil Reconstitution Following AHSCT in Lymphoma/Multiple Myeloma
Status: RECRUITING
Conditions: Lymphoma|Multiple Myeloma
Interventions: DRUG: pegylated recombinant human granulocyte-colony stimulating factor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics
Status: RECRUITING
Conditions: Laparoscopic Appendectomy|Complicated Appendicitis|Periappendicular Abscess
Interventions: DRUG: Amoxicillin clavulanic acid IV during hospitalization|DRUG: Amoxicillin clavulanic acid IV 3 days and PO until day 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Targeting Methods for Transcranial Magnetic Stimulation Treatment of Depression
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: DEVICE: Transcranial Magnetic Simulation|DEVICE: Mixed reality neuronavigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow
Status: COMPLETED
Conditions: Internal Mammary Artery Syndrome|Vasodilation
Interventions: DRUG: The topical application of a vasodilator on the LIMA graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Injectable Abatacept Using Magnetic Resonance Imaging (MRI) in Rheumatoid Arthritis (RA) Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery
Status: COMPLETED
Conditions: Exotropia or Intermittent Exotropia
Interventions: DEVICE: lateral rectus recession with biodegradable collagen implant|PROCEDURE: Lateral rectus recession without biodegradable collagen implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Regional Scintigraphic DPD Uptake in Cardiac Transthyretin Amyloidosis.
Status: RECRUITING
Conditions: Transthyretin Amyloidosis
Interventions: RADIATION: 99mTc-DPD scintigraphy|DIAGNOSTIC_TEST: Collection of blood samples and echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Efficacy and Safety Study of Omega-3-acid Ethyl Ester in Chinese Subjects With Hypertriglyceridemia.
Status: COMPLETED
Conditions: Hypertriglyceridemia
Interventions: DRUG: Omega-3-acid ethyl ester or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Healing Effect of Silver Impregnated Activated Carbon Fiber Wound Dressing on Superficial Dermal Burn
Status: COMPLETED
Conditions: Burns
Interventions: DRUG: Flamazine|DEVICE: BCT Antimicrobial Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Radiotherapy and Panitumumab in High-Risk Salivary Gland Malignancies
Status: WITHDRAWN
Conditions: Salivary Gland Malignancy
Interventions: DRUG: Postoperative Radiotherapy and Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resin Modified Glass Ionomer Versus Self-Adhesive Resin Composite Restorative Systems
Status: RECRUITING
Conditions: Secondary Caries Dental Restoration Failure of Marginal Integrity
Interventions: OTHER: Dental restoration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Trial of the VLP-Based Chikungunya Vaccine PXVX0317 (CHIKV VLP Vaccine)
Status: COMPLETED
Conditions: Chikungunya Virus
Interventions: BIOLOGICAL: CHIKV VLP/adjuvant|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis
Status: UNKNOWN
Conditions: Chronic Periodontitis
Interventions: DRUG: Nigella Sativa Oil|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia
Status: COMPLETED
Conditions: Blastic Phase|Childhood Acute Promyelocytic Leukemia With PML-RARA|Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Childhood Solid Neoplasm|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Juvenile Myelomonocytic Leukemia|Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Disease
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Abnormal Adherent Placenta.
Status: UNKNOWN
Conditions: Placenta Accreta
Interventions: DIAGNOSTIC_TEST: maternal serum creatine kinase|DIAGNOSTIC_TEST: 3D Doppler ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)
Status: RECRUITING
Conditions: Hematologic Disorders|Hemoglobinopathies|Immunodeficiencies
Interventions: DRUG: Busulfan|DRUG: Fludarabine|RADIATION: Total body irradiation|BIOLOGICAL: Stem cell transplant|DRUG: Keppra
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vertical Effects in Class II Patients Treated With Distalization
Status: COMPLETED
Conditions: Malocclusion, Angle Class II
Interventions: DEVICE: Pendulum appliance|DEVICE: clear aligners
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VR for Surgical Prehabilitation and Rehabilitation
Status: ENROLLING_BY_INVITATION
Conditions: Breast Cancer|Frailty|Surgery
Interventions: OTHER: Virtual Reality Modules Only|OTHER: Virtual Reality Modules + Live Physical Therapist Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma
Status: TERMINATED
Conditions: Anaplastic Astrocytoma|Glioblastoma
Interventions: DRUG: trabedersen|DRUG: temozolomide|DEVICE: Drug delivery system for administration of AP 12009|PROCEDURE: Placement of Drug Delivery System|DRUG: carmustine|DRUG: lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying the Effect of Methotrexate Alone Versus Methotrexate and Vitamin D on the Cardiovascular Risk of Psoriatic Patients
Status: UNKNOWN
Conditions: Psoriasis
Interventions: DRUG: Methotrexate|DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Sildenafil Oral Film in Patients With Erectile Dysfunction
Status: ACTIVE_NOT_RECRUITING
Conditions: Erectile Dysfunction
Interventions: DRUG: Sildenafil Oral Film 25 mg, 50 mg, 75 mg or 100 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial
Status: COMPLETED
Conditions: Patients Undergoing Lung Transplantation Under Extracorporeal Membrane Oxygenation
Interventions: DRUG: Administration of anesthesia: Propofol|DRUG: Administration of anesthesia: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Sequential Angiogenic Blockade for the Treatment of Recurrent Mullerian Malignancies
Status: COMPLETED
Conditions: Ovarian Cancer|Peritoneal Cancer|Fallopian Tube Cancer
Interventions: DRUG: Bevacizumab|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iontophoresis With Dexamethasone and Physical Therapy to Treat Apophysitis of the Knee in Pediatrics
Status: TERMINATED
Conditions: Apophysitis; Juvenile
Interventions: DRUG: Dexamethasone Sodium Phosphate|PROCEDURE: Iontophoresis|PROCEDURE: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.
Status: COMPLETED
Conditions: Brain Metastases|Lung Cancer|Breast Cancer|Melanoma|Malignant Glioma
Interventions: DRUG: 2B3-101|DRUG: Trastuzumab|DRUG: 2B3-101 60 mg/m2 every 4 weeks|DRUG: 2B3-101 50 mg/m2 every 3 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic CART-33 for Relapsed/Refractory CD33+ AML
Status: UNKNOWN
Conditions: Relapsed and/or Refractory CD33+ AML
Interventions: BIOLOGICAL: allogeneic CART-33
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms|Breast Diseases
Interventions: DRUG: Anastrozole|DRUG: Palbociclib|DRUG: Trastuzumab|DRUG: Pertuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiorespiratory Performance in Diabetic Elderly
Status: COMPLETED
Conditions: Diabetics Patients|Hypertensive Patients
Interventions: OTHER: Cardiorespiratory performance assessment with ergospirometry test|OTHER: Biochemical analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Clinical Benefit Response in Cancer Patients With Advanced Disease With AMT2003 Versus Placebo
Status: TERMINATED
Conditions: Gastrointestinal Cancer|Prostate Cancer|Genital Neoplasms, Female
Interventions: DRUG: AMT2003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Factorial Randomized Trial of Rendesivir and Baricitinib Plus Dexamethasone for COVID-19 (the AMMURAVID Trial)
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Baricitinib Oral Tablet [Olumiant]|DRUG: Remdesivir|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Eczema/Dermatitis and Dermal Pruritus (MK-4117-202)
Status: COMPLETED
Conditions: Eczema|Dermatitis|Dermal Pruritus
Interventions: DRUG: Desloratadine 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT