pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Training- and Cost-effectiveness of an Internet-based Lifestyle-integrated Functional Exercise Program (iLiFE)
Status: ENROLLING_BY_INVITATION
Conditions: Fall
Interventions: BEHAVIORAL: internet-based Lifestyle-integrated Functional Exercise (iLiFE)|BEHAVIORAL: upper limb exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Dose Escalation Study of HHT201 in Healthy Subjects
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease
Interventions: DRUG: Donepezil Dihydroxynaphthalate for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Ptosis to Muscular Dystrophy Oculopharyngeal by Myoblast Autologous Graft
Status: TERMINATED
Conditions: Muscular Dystrophy, Oculopharyngeal|Ptosis
Interventions: BIOLOGICAL: Myoblast autologous graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Resveratrol Supplementation on Oocyte Quality
Status: NOT_YET_RECRUITING
Conditions: Aging|Infertility
Interventions: DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Hypothermia as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Hypothermia, Induced|Rewarming|Myocardial Infarction|Percutaneous Cornonary Intervention
Interventions: DEVICE: Proteus® Cooling System|PROCEDURE: Primary Percutaneous Coronary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of G-202 (Mipsagargin) as Second-Line Therapy Following Sorafenib in Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Advanced Adult Hepatocellular Carcinoma
Interventions: DRUG: G-202
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Escitalopram|BEHAVIORAL: Interpersonal Psychotherapy|BEHAVIORAL: Clinical Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confocal Laser Endomicroscopy and Endoscopic Mucosal Resection
Status: COMPLETED
Conditions: Barrett's Mucosa With High Grade Intraepithelial Neoplasia (HGIEN)
Interventions: PROCEDURE: Endoscopic mucosal resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide in Patients With Chronic Lymphocytic Leukemia Older Than 65 Years of Age
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Leukemia
Interventions: DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Probiotics for Parkinson Disease (PD)
Status: WITHDRAWN
Conditions: Parkinson's Disease (PD)|Movement Disorders|Depression|Anxiety
Interventions: DIETARY_SUPPLEMENT: probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CONNECT DES Registrty
Status: UNKNOWN
Conditions: Stent Thrombosis|Coronary Artery Disease|Stent Stenosis|Myocardial Infarction|Ischemic Heart Disease
Interventions: DEVICE: 1st-generation drug-eluting stent|DEVICE: 2nd-generation drug-eluting stents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety and Efficacy of Optivate® in Children Under 6 Years of Age With Haemophilia A.
Status: COMPLETED
Conditions: Haemophilia A
Interventions: BIOLOGICAL: Optivate® (Human Coagulation Factor VIII)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: the Efficacy and Safety of Blueberry Yeast Fermentation Freeze Dying Powder on Promotion of Immunity
Status: COMPLETED
Conditions: Immunity
Interventions: DIETARY_SUPPLEMENT: Blueberry Yeast Fermentation Freeze Dying Powder Extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study Protocol of IAV-induced Remission Followed by Consolidation Therapy With MDCyta+Ven in ND-AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax : 100mg on day 1, 200mg on day 2, 400mg on days 3 to 8; oral administration;|DRUG: Venetoclax (Venetoclax): 400mg on day 1 to day 7; oral administration;|OTHER: utologous stem cell transplantation (ASCT) /allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUMIER² Study : LUpus Molecular Immunomonitoring to Evaluate the Risk of Relapse
Status: TERMINATED
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: OTHER: polymerase chain reaction (PCR) technique of blood transcriptome analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis (The Conquer-DVT Pilot Trial)
Status: NOT_YET_RECRUITING
Conditions: Venous Thromboembolism
Interventions: DRUG: Colchicine 0.5 mg po|DRUG: Placebo 0.5 mg po
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Clinical Trial of Supplementing Brief Psychotherapy With a Mobile App
Status: RECRUITING
Conditions: Suicidal Ideation|Suicide|Suicide Attempt
Interventions: BEHAVIORAL: Ecological momentary assessment (EMA)|BEHAVIORAL: Treatment as usual (TAU)|BEHAVIORAL: Brief skills sessions plus EMI skills practice prompts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Telephone Psychological Intervention for Depressive Symptoms in Caregivers
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Multicomponent Cognitive Behavioral Telephone Intervention|BEHAVIORAL: Telephone Intervention Pleasant Activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fed Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Valacyclovir Hydrochloride Tablets 1000mg|DRUG: Valtrex® 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Diffusion Optics Technology (DOT) Spectacle Lenses on Choroidal Thickness
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia|Myopia Progression|Juvenile Myopia
Interventions: DEVICE: Diffusion Optics Technology (DOT) Pattern Spectacle Lens|DEVICE: Control Spectacle Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of NMES on Spirometry Values, Functional Capacity and Quality of Life in Patients With Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: OTHER: Neuromuscular Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars
Status: TERMINATED
Conditions: Hypertrophic Scar
Interventions: BIOLOGICAL: PRP Injection|DRUG: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: CDX-0159|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Potential of Air Structuring Protein to Elicit Allergic Reactions in Mold Sensitized People
Status: COMPLETED
Conditions: Allergy to Mold
Interventions: OTHER: Air Structuring Protein|OTHER: Placebo sorbet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Family Therapy and Anorexia Nervosa : Which is the Best Approach?
Status: UNKNOWN
Conditions: Anorexia Nervosa
Interventions: BEHAVIORAL: Systemic Family Therapy|BEHAVIORAL: Multiple Family Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Early Radiation Oncology Involvement Alongside Standard Oncologic Care in the Managemet
Status: RECRUITING
Conditions: Radiation Therapy|Metastatic Cancer
Interventions: OTHER: Questionnaires|COMBINATION_PRODUCT: Early Radiation Oncology Involvement Alongside Standard Oncologic Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drinks:Ration - Combat Stress Randomized Controlled Trial
Status: COMPLETED
Conditions: Alcohol Abuse|Mental Disorder|Mental Health Issue
Interventions: BEHAVIORAL: Drinks:Ration app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Premenstrual Symptoms and Aromatherapy
Status: NOT_YET_RECRUITING
Conditions: Premenstrual Syndrome|Aromatherapy
Interventions: OTHER: Aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Steroid Sparing Effect of Xolair (Omalizumab) in Patients With Persistent Eosinophilic Bronchitis
Status: COMPLETED
Conditions: Steroid and/or Prednisone Dependent Asthma|Eosinophilic Bronchitis
Interventions: BIOLOGICAL: Omalizumab (Xolair)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Recurrence and Metastasis of Colorectal Cancer by Comparing Huaier With Capecitabine Monotherapy
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Huaier granule|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atovaquone (Mepron®) Combined With Conventional Chemotherapy for de Novo Acute Myeloid Leukemia (AML)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Atovaquone|DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Etoposide|DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Transplant for Relapsing C. Difficile Infection
Status: UNKNOWN
Conditions: Clostridium Difficile
Interventions: BIOLOGICAL: Fecal Microbiota Transplantation|BIOLOGICAL: Sham Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability of Fluorescent Camera and Caries Detection Dye Versus the Visual Tactile Method
Status: UNKNOWN
Conditions: Dental Caries
Interventions: DEVICE: fluorescent camera|OTHER: caries detector dye|DIAGNOSTIC_TEST: visual tactile assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Dietary Effects on Weight Loss and Lipid Profile in Sedentary Men
Status: COMPLETED
Conditions: Men|Life Style|Lipid Metabolism Disorders|Obesity|Overweight
Interventions: DIETARY_SUPPLEMENT: NCD|DIETARY_SUPPLEMENT: LCD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of GT160-246 Versus Vancomycin in Patients With Clostridium Difficile-Associated Diarrhea
Status: COMPLETED
Conditions: Clostridium Difficile-Associated Diarrhea|Clostridium Enterocolitis|Clostridium Difficile Diarrhea|Antibiotic-associated Colitis|Antibiotic-associated Diarrhea
Interventions: DRUG: GT160-246
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: OTHER: Thai traditional massage|OTHER: No massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CD19 CAR-T Cell Therapy for Relapsed/Refractory B-cell Lymphoma and B-cell Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: B Cell Lymphoma|B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Anti-CD19 CAR-T Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fertility in Young Adults Who Did (Not) Store Testicular Tissue Before a Treatment Leading to Fertility Problems
Status: ENROLLING_BY_INVITATION
Conditions: Childhood Cancer|Hematological Disorders
Interventions: DIAGNOSTIC_TEST: Physical examination|DIAGNOSTIC_TEST: Scrotum ultrasound|DIAGNOSTIC_TEST: Blood sample|DIAGNOSTIC_TEST: Semen analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Japanese Phase 1 Study to Evaluate Tolerated Dose, Safety, and Efficacy of Pomalidomide in Patients With Refractory or Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of an Intervention on Health in Older Care Home Residents
Status: WITHDRAWN
Conditions: Sedentary Behavior|Frail Elderly Syndrome|Frailty|Lifestyle, Sedentary|Life Style Induced Illness
Interventions: OTHER: Wellness programme provided by Oomph! Wellness company
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: THE PARTNER TRIAL: Placement of AoRTic TraNscathetER Valve Trial
Status: COMPLETED
Conditions: Critical Aortic Stenosis
Interventions: DEVICE: Edwards SAPIEN Transcatheter Heart Valve|DEVICE: Surgical Valve Replacement|OTHER: medical management and/or balloon aortic valvuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DEVICE: Multi-method Neuroendocrine and Neuroimaging Procedure Scan 1|DEVICE: Multi-method Neuroendocrine and Neuroimaging Procedure Scan 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Functional and Molecular Characterization of Treatment Response in Tumors in the Oral Cavity Using Optical Spectroscopy
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Cancer
Interventions: DEVICE: Optical Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biomechanical Analysis of CAM Boot and EVENUp Lift
Status: ACTIVE_NOT_RECRUITING
Conditions: Biomechanics|Limb Length Discrepancy
Interventions: DEVICE: Controlled Ankle Movement Boot|DEVICE: EVENUp Lift
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Wound Complication Following TMA With Aid of Electrospun Fiber Matrix
Status: NOT_YET_RECRUITING
Conditions: Amputation|Wound; Foot|Wound Complication
Interventions: DEVICE: Synthetic electrospun fiber matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aspirin Versus Aspirin+Clopidogrel as Antithrombotic Treatment Following TAVI
Status: COMPLETED
Conditions: Aortic Valve Disease|Myocardial Infarction|Stroke|Bleeding
Interventions: DRUG: Clopidogrel|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the 18F-PSMA Positron Emission Tomography (PET)/CT in Patients With Medullary Thyroid Cancer
Status: RECRUITING
Conditions: Medullary Thyroid Cancer|Medullary Thyroid Carcinoma|Thyroid Carcinoma, Medullary|Thyroid Cancer, Medullary
Interventions: DRUG: 18F-PSMA-1007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Yoga in Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Yoga Group|BEHAVIORAL: Stretching Control Group|BEHAVIORAL: Waitlist Control Group|OTHER: Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Attention Deficit Hyperactivity Disorder|Sleep Disturbance
Interventions: DIETARY_SUPPLEMENT: Melatonin|BEHAVIORAL: Bedtime Bank
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19|Respiratory Failure
Interventions: DEVICE: Active PBMT/sMF|DEVICE: Placebo PBMT/sMF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
Status: COMPLETED
Conditions: Fatigue|Aging
Interventions: DRUG: Placebo sildenafil|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Irinotecan and Capecitabine Versus(vs) Cisplatin and Capecitabine in Patients With Esophago-Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Cisplatin, Irinotecan, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of OCA in Combination With BZF Evaluating Efficacy, Safety, and Tolerability in Participants With PBC
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: Obeticholic acid|DRUG: Bezafibrate 200 MG|DRUG: OCA Placebo|DRUG: Bezafibrate 200 mg Placebo|DRUG: Bezafibrate 400 MG|DRUG: Bezafibrate 400 mg Placebo|DRUG: OCA|DRUG: Bezafibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: the Related Factors of Bariatric Surgery on Gastroesophageal Reflux Disease
Status: UNKNOWN
Conditions: Gastroesophageal Reflux|Bariatric Surgery
Interventions: PROCEDURE: 2 cm away from the pylorus edge|PROCEDURE: 4 cm away from the pylorus edge|PROCEDURE: 6 cm away from the pylorus edge|PROCEDURE: LRYGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness and Duration of Effect of Open Treatment in Attention Deficit Hyperactivity Disorder (ADHD) Patients Treated With Lisdexamfetamine Dimesylate(Vyvanse)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: LDX Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral CF101 Tablets and Methotrexate Treatment in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CF101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Equivalence Among Antiepileptic Drug Generic and Brand Products in People With Epilepsy: Single-Dose 6-Period Replicate Design (EQUIGEN Single-Dose Study)
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Lamotrigine Generic "A" Lamotrigine Generic "B" Lamotrigine "Brand"|DRUG: lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Volunteers to Prove That 2 Rotigotine Patches From Different Manufacturing Processes Deliver Equivalent Drug Amount to the Body.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rotigotine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of PESF on Oxygen Saturation, Quality of Life and Exercise Capacity in COPD
Status: TERMINATED
Conditions: COPD
Interventions: DEVICE: Pulsating Electrostatic Field|DEVICE: SHAM Pulsating Electrostatic Field
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy, Radiation Therapy, and Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Adenosquamous Cell Lung Cancer|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer
Interventions: DRUG: paclitaxel|DRUG: carboplatin|DRUG: gefitinib|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia
Status: TERMINATED
Conditions: Hyponatremia
Interventions: DRUG: Tolvaptan|DRUG: Placebo|BEHAVIORAL: Hepatic Encephalopathy Assessment|BEHAVIORAL: Quality of Life Assessment|BIOLOGICAL: Vital signs|BIOLOGICAL: Blood laboratory tests|PROCEDURE: Ascites Evaluation|PROCEDURE: Edema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Structured Intervention to Optimize the Use of Mirabegron
Status: COMPLETED
Conditions: Overactive Bladder Syndrome
Interventions: BEHAVIORAL: Review the use of mirabegron and its discontinuation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Personalized Training at Home Combining Endurance and Resistance in Patients Suffering From Marfan Syndrome
Status: COMPLETED
Conditions: Marfan Syndrome
Interventions: OTHER: Endurance training|OTHER: Muscle building training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Eltrombopag for the Prevention of Chemotherapy Induced Thrombocytopenia
Status: TERMINATED
Conditions: Sarcoma, Soft Tissue|Osteosarcoma|Neoplasms, Connective and Soft Tissue
Interventions: DRUG: Eltrombopag
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neural and Metabolic Factors in Carbohydrate Reward
Status: RECRUITING
Conditions: Carbohydrate Metabolism
Interventions: OTHER: CS- Beverage|OTHER: CS+Fast|OTHER: CS+Slow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy
Status: UNKNOWN
Conditions: Hypertrophic Obstructive Cardiomyopathy
Interventions: DRUG: Esmolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of L-Carnitine in the Management of Acute Clozapine Intoxication
Status: NOT_YET_RECRUITING
Conditions: Clozapine Poisoning
Interventions: DIETARY_SUPPLEMENT: L-Carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|KRAS Activating Mutation|Advanced Cancer|Metastatic Cancer|Malignant Neoplasm of Lung|Malignant Neoplastic Disease
Interventions: DRUG: avutometinib (VS-6766) and adagrasib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion
Status: COMPLETED
Conditions: Cervical Disc Herniation|Cervical Degenerative Disc Disease|Cervical Spondylotic Myelopathy|Dysphagia|Osteoarthritis of Cervical Spine
Interventions: DRUG: Methylprednisolone Acetate|OTHER: Hemostatic Matrix Kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Myocardial Perfusion MRI
Status: COMPLETED
Conditions: Myocardial Perfusion Imaging|Magnetic Resonance Imaging
Interventions: DRUG: Gadobutrol (Gadavist,Gadovist, BAY86-4875)|DRUG: Gadobutrol (Gadavist,Gadovist, BAY86-4875)|DRUG: Gadobutrol (Gadavist,Gadovist, BAY86-4875)|DRUG: Gadobutrol (Gadavist,Gadovist, BAY86-4875)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Age 9 Follow-up of Preventive Intervention (Denver)
Status: COMPLETED
Conditions: Child Rearing|Risk Reduction Behavior|Reproductive Behavior
Interventions: BEHAVIORAL: home visitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Whole Body Hyperthermia (WBH) as a Rapid Treatment for Fibromyalgia
Status: WITHDRAWN
Conditions: Fibromyalgia
Interventions: DEVICE: The Whole Body Hyperthermia system uses water-filtered infrared-A (wIRA) heat radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Premarin® (oral) vs. Alora® (transdermal)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Belatacept Early Steroid Withdrawal Trial
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Alemtuzumab|DRUG: rabbit antithymocyte globulin|DRUG: Belatacept|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil|DRUG: early cessation of steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of Romidepsin in Combination With Antiretroviral Therapy in HIV-Infected Adults With Suppressed Viral Load
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Romidepsin|DRUG: Placebo for Romidepsin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Augmented Rituximab and ICE for Pts With Primary Refractory and Poor Risk Relapsed Aggressive B-Cell NHL
Status: COMPLETED
Conditions: Lymphoma|B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Rituximab, Ifosfamide, Carboplatin, VP-16, Mesna, G-CSF, Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeoPHOEBE: Neoadjuvant Trastuzumab + BKM120 in Combination With Weekly Paclitaxel in HER2-positive Primary Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Newly Diagnosed, Primary Breast Cancer
Interventions: DRUG: BKM120|DRUG: Trastuzumab|DRUG: Paclitaxel|DRUG: BKM120 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of High-Intensity Interval Training on Depressive Symptoms in Hong Kong Older Adults
Status: RECRUITING
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: HIIT|BEHAVIORAL: Baduanjin|BEHAVIORAL: Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells Transplantation to Patients With Relapsed/Refractory Aplastic Anemia.
Status: UNKNOWN
Conditions: Aplastic Anemia
Interventions: BIOLOGICAL: bone marrow derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: No More Sleepless Nights in Perimenopause
Status: NOT_YET_RECRUITING
Conditions: Insomnia|Menopause
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy for Insomnia (CBT-I)|DRUG: Hormone Replacement Therapy (HRT)|BEHAVIORAL: Sleep Hygiene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palliative Care Oncology in Patients With Relapsed, Refractory, and High-Risk Leukemias or MDS
Status: RECRUITING
Conditions: Leukemia, Acute|AML, Adult|ALL, Adult|Myelodysplastic Syndromes
Interventions: OTHER: Palliative Care Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paraprofessional Treatment of Depression in Vietnam
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: OTHER: Behavioral Activation + Medication|DRUG: Guideline Antidepressant Medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: CABAZITAXEL XRP6258|DRUG: PEG-G-CSF|DRUG: Prednisolone|DRUG: Dexchlorpheniramine or Diphenhydramine|DRUG: Ranitidine|DRUG: Metoclopramide, Granisetron, or Ondansetron|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Safety of Everolimus in Addition to Cyclosporine Microemulsion in Cardiac Transplant Recipients.
Status: COMPLETED
Conditions: Cardiac Transplantation
Interventions: DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Intensive Care Unit Patients
Status: COMPLETED
Conditions: Covid19|SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere
Interventions: DRUG: Patch, Nicotine|DRUG: Patch, Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure
Status: ACTIVE_NOT_RECRUITING
Conditions: Patent Foramen Ovale|Cryptogenic Stroke|Older Patients|Medical Treatment|Recurrent Stroke
Interventions: PROCEDURE: Transcatheter PFO closure|DRUG: Optimal medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contribution of the Evaluation of Body Composition by Connected Scale in the Effectiveness of a Reconditioning Program Through Physical Activity Adapted for Patients Suffering From Chronic Diseases
Status: RECRUITING
Conditions: Chronic Disease
Interventions: DEVICE: Body Comp Pro connected scale (Withings manufacturer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD
Status: COMPLETED
Conditions: Chronic Kidney Disease|Poorly-Controlled Hypertension
Interventions: DRUG: Chlorthalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HIV Liver Regeneration Project for HIV Patients With Cirrhosis by Autologous Bone Marrow Transplantation
Status: UNKNOWN
Conditions: HIV Infection|AIDS|Cirrhosis
Interventions: PROCEDURE: Hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Anastomosis Duodenal Ileal Bypass (SADI) for Sleeve Revision
Status: ACTIVE_NOT_RECRUITING
Conditions: Bariatric Surgery Candidate|Severe Obesity
Interventions: PROCEDURE: Single Anastomosis Duodenal Ileal Bypass (SADI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Network-based rTMS in Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease, Late Onset|Alzheimer Disease|Cognitive Deterioration
Interventions: DEVICE: rTMS|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude
Status: COMPLETED
Conditions: Acute Mountain Sickness
Interventions: OTHER: Breathing procedure 1|OTHER: Breathing procedure 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Safety, Tolerability and Pharmacokinetics of CS0159 in Chinese Healthy Subjects
Status: COMPLETED
Conditions: Primary Biliary Cholangitis
Interventions: DRUG: CS0159|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors
Status: COMPLETED
Conditions: Brain Tumor|Central Nervous System Tumor
Interventions: BIOLOGICAL: Sargramostim|DRUG: cyclophosphamide|DRUG: melphalan|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: bone marrow ablation with stem cell support|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omacetaxine and Venetoclax for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Harboring Mutant RUNX1
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Recurrent Acute Biphenotypic Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Biphenotypic Leukemia|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: Omacetaxine Mepesuccinate|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients.
Status: UNKNOWN
Conditions: Hypocalcemia|Vitamin D Deficiency|Postoperative Complications|Postoperative Nausea|Postoperative Pain|Voice Hoarseness|Hypoparathyroidism Postprocedural
Interventions: DRUG: Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland).|DRUG: Placebo oral sweetener (Clio tablets, sweetener with a dispenser, Instantina GES, Vienna, Austria).|DIAGNOSTIC_TEST: Preoparative blood laboratory tests|DIAGNOSTIC_TEST: Postoperative laboratory blood tests at 6 hour|DIAGNOSTIC_TEST: Postoperative laboratory blood tests at 24 hour|DIAGNOSTIC_TEST: Postoperative laboratory drainage fluid tests at 24 hour|PROCEDURE: Total thyroidectomy|OTHER: Symptomatic hypocalcaemia at 6 hour|OTHER: Symptomatic hypocalcaemia at 24 hour|OTHER: Postoperative pain at 6 hour|OTHER: Postoperative pain at 24 hour|OTHER: Postoperative nausea and vomiting at 6 hour|OTHER: Postoperative nausea and vomiting at 24 hour|OTHER: Postoperative sore throat and hoarseness at 6 hour|OTHER: Postoperative sore throat and hoarseness at 24 hour
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Study of Bevacizumab Combined With Fluzoparib/Chemotherapy or Fluzoparib in the Treatment of Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: Bevacizumab|DRUG: chemotherapy|DRUG: Fluzoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Protein Supplementation on Lean Body Mass Recovery From Extreme Military Training
Status: COMPLETED
Conditions: Military Operational Stress Reaction|Malnutrition (Calorie)|Weight Loss|Muscle Wasting
Interventions: DIETARY_SUPPLEMENT: Protein, High-Protein, and Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: REnal Sympathetic dEnervaTion as an a Adjunct to Catheter-based VT Ablation
Status: COMPLETED
Conditions: Ventricular Tachycardia
Interventions: DEVICE: Renal sympathetic denervation|DEVICE: VT ablation alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Imiquimod Topical Cream in Early Stage Cutaneous T-cell Lymphoma
Status: WITHDRAWN
Conditions: Mycosis Fungoides
Interventions: DRUG: 3.75% Imiquimod Cream|DRUG: 0.1% Fluocinonide Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tactile Electrosurgical Ablation in Cases of Dysfunctional Uterine Bleeding
Status: COMPLETED
Conditions: Dysfunction Uterine Bleeding
Interventions: DEVICE: Tactile electrosurgical ablation probe|DEVICE: Hysteroscopic endometrial ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Valsartan vs Amlodipine and Low BP on Kidney Outcomes in Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Cardiac outcomes on treatment with valsartan|DRUG: Cardiac outcomes on treatment with amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Voriconazole or Placebo in the Prophylaxis of Lung Infiltrates in Patients Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia
Status: TERMINATED
Conditions: Leukemia, Myelocytic, Acute
Interventions: DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Combined Treatment for Young Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: lithium plus carbamazepine|DRUG: lithium plus valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Removal of a Diffuse Low-grade Glioma of the Supplementary Motor Area
Status: COMPLETED
Conditions: Cognitive Disorders|Motor Disorders|Low-grade Glioma
Interventions: OTHER: Test battery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Tadalafil Once-a-Day for 12 Weeks in Japanese Men With Benign Prostatic Hyperplasia Followed by an Open-Label Extension
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Tadalafil 2.5 mg|DRUG: Tadalafil 5 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Cognitive Assessment by BoCA
Status: RECRUITING
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Vascular Dementia|Frontotemporal Dementia|Parkinson Disease|Multiple Sclerosis|TBI
Interventions: DIAGNOSTIC_TEST: Boston Cognitive Assessment (BoCA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 2ccPA Study in Patients With Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis (OA) of the Knee
Interventions: DRUG: 2ccPA|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter
Status: COMPLETED
Conditions: Goiter
Interventions: PROCEDURE: Total thyroidectomy|PROCEDURE: Dunhill operation|PROCEDURE: Bilateral subtotal thyroidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AAV8-hCocH for Cocaine Use Disorder
Status: RECRUITING
Conditions: Cocaine Dependence, in Remission
Interventions: DRUG: AAV8-hCocH|DRUG: AAV8-hCocH|DRUG: AAV8-hCocH
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of the Arrival on the French Market of New First Line Oral Treatments on the Delay Between MS Onset and First Disease Modifying Treatment (DMTs) Administration
Status: COMPLETED
Conditions: C10.114.375.500
Interventions: OTHER: Delay between MS onset and introduction of first line DMT|OTHER: EDI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vitamin C and Tyrosine Kinase Inhibitor in Lung Cancer Patients With Epidermal Growth Factor Receptor Mutations
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Vitamin C|DRUG: Tyrosine kinase inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LAA Excision With AF Ablation Versus Oral Anticoagulants for Secondary Prevention of Stroke
Status: COMPLETED
Conditions: Atrial Fibrillation|Stroke|Systemic Embolism
Interventions: PROCEDURE: Thoracoscopic LAA Excision plus AF Ablation|DRUG: Warfarin or Novel Oral Anticoagulants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety of Two Lots of NBP608 Compared to Zostavax in Healthy Adult Aged 50 and Over
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: NBP608|BIOLOGICAL: Zostavax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Step 2 of A Two-step Trial to Evaluate the Effectiveness and Safety of Remimazolam Besylate for Sedation in ICU Patients
Status: COMPLETED
Conditions: Sedative|Mechanical Ventilation
Interventions: DRUG: Remimazolam besylate|DRUG: Propofol|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT