pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients
Status: NOT_YET_RECRUITING
Conditions: Cutaneous Squamous Cell Carcinoma|Actinic Keratoses|Skin Cancer|Organ Transplant Recipients|Immunotherapy
Interventions: DRUG: Calcipotriol Only Product in Cutaneous Dose Form|DRUG: Vaseline|DRUG: Topical 5FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Trial to Find and Investigate a Safe Dose of BI 836858 in Combination With Decitabine for Patients With Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Decitabine|DRUG: BI 836858
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of Corneal Incision Size After Intraocular Lens (IOL) Implantation
Status: COMPLETED
Conditions: Cataracts
Interventions: DEVICE: UltraSert Preloaded Delivery System|DEVICE: iTec Preloaded Delivery System|DEVICE: iSert Preloaded Delivery System|DEVICE: Monarch III D Manual IOL Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Timed Aspirin Chronobiome Study
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: Aspirin 81 mg|DRUG: Celecoxib 200mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of 8-weeks of Glecaprevir/Pibrentasvir in Treatment-Naïve Adults With HCV Genotype 1-6 and Aspartate Aminotransferase to Platelet Ratio Index (APRI) ≤1
Status: COMPLETED
Conditions: Hepatitis C Virus (HCV)
Interventions: DRUG: Glecaprevir/Pibrentasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of N-acetylcysteine in Thrombotic Thrombocytopenia Purpura
Status: COMPLETED
Conditions: Purpura, Thrombotic Thrombocytopenic|TTP
Interventions: DRUG: N-Acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
Status: NOT_YET_RECRUITING
Conditions: Retinopathy|Retinal Vein Occlusion|Diabetic Retinopathy|Macular Degeneration
Interventions: COMBINATION_PRODUCT: Fluorescein sodium and Zeiss FF450 fundus camera|COMBINATION_PRODUCT: MB-102 and Zeiss FF450 fundus camera|COMBINATION_PRODUCT: Fluorescein sodium and commercially available optical angiography imaging system|COMBINATION_PRODUCT: MB-102 and commercially available optical angiography imaging system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pilot Study of Repetitive Transcranial Magnetic Stimulation for Treatment of Methamphetamine Use Disorders
Status: WITHDRAWN
Conditions: Methamphetamine Abuse
Interventions: DEVICE: Dual Target Theta Burst Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gabapentin for Bipolar & Cannabis Use Disorders
Status: COMPLETED
Conditions: Bipolar I Disorder|Bipolar II Disorder|Cannabis Use Disorder|Substance Use Disorders
Interventions: DRUG: Gabapentin|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lamotrigine|DRUG: BI 409306|DRUG: Placebo|DRUG: BI 425809
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postmarket Clinical Follow-up Study to Confirm the Performance of the Wearable Pulse-Oximeter BrOxy M (SOMBRERO)
Status: COMPLETED
Conditions: Laboratory Testing on Healthy Volunteers to Verify SpO2 and Heart Rate (HR) Accuracy of BrOxy M
Interventions: OTHER: Controlled desaturation study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical and Electrophysiological Outcomes of tDCS in Patients With Treatment Resistant OCD
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MILESTONE-CD -A Prospective Multiomic Inception Real -Life Study To Evaluate Predictors of Disease Outcomes & respoNse to Biologic Treatment in Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease of Intestine
Interventions: DIAGNOSTIC_TEST: combination of diagnostic tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The eSVS® Mesh Randomized Post-Market Study
Status: TERMINATED
Conditions: Coronary Artery Disease|Myocardial Ischemia|Coronary Disease|Heart Diseases|Cardiovascular Diseases|Arteriosclerosis|Arterial Occlusive Diseases|Vascular Diseases
Interventions: DEVICE: eSVS® Mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Single Ascending and Multiple Dose of GLPG0555
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: GLPG0555|DRUG: placebo|DRUG: GLPG0555|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Metastatic/Advanced RAS-Wild Type Colorectal Cancer.
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: BKM120|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estradiol Suppression for the Treatment of Metastatic Breast Cancer in Premenopausal Women
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Anastrozole (Arimidex)|DRUG: Goserelin (Zoladex)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer|Metastatic Pancreatic Cancer|Metastatic Ovarian Cancer|Metastatic Breast Carcinoma|Metastatic Endocrine Tumors/ Neuroendocrine Tumors
Interventions: BIOLOGICAL: Young TIL|DRUG: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Pembrolizumab (Keytruda)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Steroid-induced Reduction of Surgical Stress Study
Status: WITHDRAWN
Conditions: Coronary Artery Stenosis|Coronary Artery Bypass Graft Surgery
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Supporting the Recovery Needs of Patients Following Intensive Care
Status: UNKNOWN
Conditions: Post Intensive Care Unit Syndrome|Post Intensive Care Syndrome|ICU Acquired Weakness|Intensive Care Unit Syndrome|Intensive Care Unit Acquired Weakness
Interventions: OTHER: Former ICU patient and caregiver workshops|OTHER: Health care professional workshops
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer of Unknown Primary Site
Interventions: DRUG: Alectinib|DRUG: Vismodegib|DRUG: Ipatasertib|DRUG: Olaparib|DRUG: Erlotinib|DRUG: Bevacizumab|DRUG: Vemurafenib|DRUG: Cobimetinib|DRUG: Trastuzumab Subcutaneous (SC)|DRUG: Pertuzumab|DRUG: Atezolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Entrectinib|DRUG: Ivosidenib|DRUG: Pemigatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder|Alcohol Abuse|Alcoholism|Drinking Behavior|Drinking Problem
Interventions: DEVICE: Active Transcranial Magnetic Simulation|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ixazomib -Daratumumab Without Dexamethasone (IDara) in Elderly Relapse Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: COMBINATION_PRODUCT: Ixazomib and Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Trial of Phenlarmide in China
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Phenlarmide Tablets|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of Different Irrigation and Disinfection Methods on Post-operative Pain (PP)
Status: COMPLETED
Conditions: Post-operative Pain|Apical Periodontitis
Interventions: DEVICE: EDDY|DEVICE: Diode Laser device|DEVICE: Conventional irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Aripiprazole From Apipe 10 mg Orally Disintegrating Tablets (Man. by: P&C Labs (Pellets & CR Products), Egypt) Versus Abilify 10 mg Orodispersible Tablets (Otsuka Pharmaceutical Netherlands B.V., Netherlands)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Apipe (Aripiprazole10 mg)|DRUG: Abilify (Aripiprazole10 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of the Mediterranean Diet on Cardiovascular Risk Profile in Men and Women (ALIMED)-Part 2
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: Experimental: Men and Mediterranean diet|BEHAVIORAL: Experimental: Women and Mediterranean diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Nitazoxanide|DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics and Safety of Dupilumab in Participants ≥2 Years to <12 Years of Age With Uncontrolled Chronic Spontaneous Urticaria (CSU) (LIBERTY-CSU CUPIDKids)
Status: RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: DRUG: Dupilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity and Efficacy of GSK S. Aureus Candidate Vaccine (GSK3878858A) When Administered to Healthy Adults (Dose-escalation) and to Adults 18 to 64 Years of Age With a Recent S. Aureus Skin and Soft Tissue Infection (SSTI)
Status: ACTIVE_NOT_RECRUITING
Conditions: Infections, Soft Tissue
Interventions: BIOLOGICAL: Sa-5Ag half dose non-adjuvanted|BIOLOGICAL: Sa-5Ag full dose non-adjuvanted|BIOLOGICAL: Sa-5Ag half dose adjuvanted|BIOLOGICAL: Sa-5Ag full dose adjuvanted|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Efficacy and Safety of Vildagliptin as add-on Insulin Therapy in T2DM Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: Vildagliptin (LAF237)|DRUG: Placebo|DRUG: Insulin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunity Induced by VSV-EBOV and Assessment of a Booster Dose in Individuals at Potential Occupational Risk for Exposure
Status: NOT_YET_RECRUITING
Conditions: Ebola Vaccine
Interventions: BIOLOGICAL: ERVEBO® (rVSV∆G-ZEBOV-GP)|BIOLOGICAL: ERVEBO® (rVSV∆G-ZEBOV-GP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Impact of a School Program Combining - Promotion of HPV Vaccination and HPV Vaccine Offer in Middle School - on Adherence to HPV Vaccination in Middle School Students
Status: COMPLETED
Conditions: Papilloma Viral Infection
Interventions: DRUG: Gardasil 9, 9-Valent Intramuscular Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LungTech: Stereotactic Body Radiotherapy (SBRT) of Inoperable Centrally Located NSCLC
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer Stage I|Non-small Cell Lung Cancer Stage II
Interventions: RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Feasibility of PiCSO Therapy in Patients With ST Elevation Inferior Wall Myocardial Infarction.
Status: TERMINATED
Conditions: STEMI - ST Elevation Myocardial Infarction|Inferior Wall Myocardial Infarction
Interventions: DEVICE: PiCSO Impulse System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of the Training Given to the Unable to Breastfeed Mothers Staying in the Mother's Hotel
Status: RECRUITING
Conditions: Breast Feeding|Separation, Family
Interventions: OTHER: Giving breastfeeding training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Fibromyalgia Integrative Training for Adolescents With Juvenile Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Myofascial Pain Syndrome|Muscular Diseases|Musculoskeletal Disease|Rheumatic Diseases
Interventions: BEHAVIORAL: Fibromyalgia Integrative Training for Teens|BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Graded Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)
Status: COMPLETED
Conditions: Brain Injury
Interventions: DRUG: Methylphenidate|BEHAVIORAL: Memory and Attention Training|OTHER: Placebo as both treatments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Scoliosis|Adolescent Idiopathic Scoliosis (AIS)
Interventions: OTHER: Optimized brace versus conventional Boston brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of MOv18 IgE
Status: COMPLETED
Conditions: Human Cancers
Interventions: DRUG: MOv18 IgE|DRUG: MOv18 IgE|DRUG: MOv18 IgE|DRUG: MOv18 IgE|DRUG: MOv18 IgE|DRUG: MOv18 IgE|DRUG: MOv18 IgE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: TT301|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Ibrutinib (a Bruton's Tyrosine Kinase Inhibitor), Versus Temsirolimus in Patients With Relapsed or Refractory Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy
Status: COMPLETED
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Severe Erythema Multiforme - CORTICO
Status: NOT_YET_RECRUITING
Conditions: Erythema Multiforme
Interventions: DRUG: Prednisone 20 Mg|DRUG: Oral Placebo|DRUG: Methylprednisolone 120 Mg|DRUG: IV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Dose Study to Assess How the Drug Enters, Moves Through and Exits the Body, Safety and Tolerability of Safinamide in Healthy Adult Chinese Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Safinamide 50 mg|DRUG: Safinamide 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Adebrelimab With Dalpiciclib for Resectable Esophageal Squamous Cell Carcinomas
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Adebrelimab|DRUG: Dalpiciclib 100mg|DRUG: Dalpiciclib 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Status: RECRUITING
Conditions: Compartment Syndrome of Leg|Extracorporeal Membrane Oxygenation Complication|Limb Ischemia|Limb Ischemia, Critical
Interventions: DEVICE: MY01 + Standard of Care|DEVICE: 14-Gauge Slit Catheter + Standard of Care|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: SMART Effectiveness Trial
Status: COMPLETED
Conditions: Opioid-use Disorder|Opioid Dependence|Treatment Adherence
Interventions: BEHAVIORAL: Contingency Management (CM)|BEHAVIORAL: Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DEXTENZA Therapy for Treatment of Allergic Conjunctivitis
Status: COMPLETED
Conditions: Bilateral Conjunctivitis (Disorder)
Interventions: DRUG: Dexamethasone ophthalmic insert 0.4Mg|DRUG: 0.2% loteprednol etabonate ophthalmic suspension|DRUG: olopatadine hydrochloride ophthalmic solution 0.7%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Post-transplant Lymphoproliferative Disorder|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Hairy Cell Leukemia|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|T-cell Large Granular Lymphocyte Leukemia|Testicular Lymphoma|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific|Waldenström Macroglobulinemia
Interventions: BIOLOGICAL: anti-endosialin/TEM1 monoclonal antibody MORAb-004|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study Of PF-06291874 As Oral Monotherapy To Treat Adults With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type II
Interventions: DRUG: Placebo|DRUG: PF-06291874|DRUG: PF-06291874|DRUG: PF-06291874|DRUG: PF-06291874
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Human Anti-TNF Monoclonal Antibody Adalimumab in Canadian Subjects With Moderate to Severe Crohn's Disease (ACCESS)
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: BIOLOGICAL: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess BMD and Bone Turnover Response to 5 mg Daily Risedronate Treatment in Women With PMO
Status: COMPLETED
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: risedronate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nutrition in Postpartum and Early Life Feeding Study
Status: RECRUITING
Conditions: Glycemic Response|Breast Feeding, Exclusive|Eating Behavior
Interventions: BEHAVIORAL: Beef Diet Intervention|BEHAVIORAL: Impossible Beef Diet Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post Market Surveillance of OZURDEX® for Branch Retinal Vein Occlusion (BRVO) and Central Retinal Vein Occlusion (CRVO)
Status: COMPLETED
Conditions: Retinal Vein Occlusion|Macular Edema
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Guided Bilateral Superficial Cervical Plexus Block in Patients Undergoing Total Thyroidectomy.
Status: COMPLETED
Conditions: Analgesia Obtained With a Local Wound Infiltration of Lidocain|Analgesia Obtained With a Ultrasound Guided Cervical Plexus Block Using Lidocain|Postoperative Pain
Interventions: PROCEDURE: Block type
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer, Metastatic
Interventions: BIOLOGICAL: BioTTT001 intraperitoneal infusion|DRUG: SOX regimen|DRUG: toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III Ovarian Cancer
Status: TERMINATED
Conditions: Malignant Ovarian Mixed Epithelial Tumor|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Primary Peritoneal Carcinoma|Stage III Ovarian Cancer|Undifferentiated Ovarian Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|BIOLOGICAL: Filgrastim|DRUG: Paclitaxel|PROCEDURE: Peripheral Blood Stem Cell Transplantation|DRUG: Topotecan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Restylane Lyft With Lidocaine in the Dorsal Hand
Status: COMPLETED
Conditions: Volume Deficit in the Hand
Interventions: DEVICE: Restylane Lyft with Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Multi-site Prospective Study to Assess the Efficacy and Safety of MMF in the Treatment of Proliferative IgA Nephropathy(IgAN)
Status: COMPLETED
Conditions: IgA Nephropathy (IgAN)
Interventions: DRUG: mycophenolate mofetil plus lower dose of Prednisone|DRUG: Prednisone in full dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Radiation to Improve T-Cell Infiltration in Pancreatic Cancer
Status: COMPLETED
Conditions: Primarily Resectable Pancreatic Cancer
Interventions: RADIATION: neoadjuvant photon radiation|RADIATION: neoadjuvant photon radiation|RADIATION: neoadjuvant photon radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Pregabalin Administration on Catheter- Related Bladder Discomfort in Orthopedic Surgical Operations
Status: WITHDRAWN
Conditions: Pregabalin on Catheter Related Bladder Discomfort
Interventions: DRUG: Placebo oral capsule|DRUG: Pregabalin Oral Capsule [Lyrica] 75mg|DRUG: Pregabalin Oral Capsule [Lyrica] 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acthar Gel for Active Systemic Lupus Erythematosus (SLE)
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Acthar Gel|DRUG: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccination Against Human Papillomavirus (HPV) With the 9-valent Vaccine in HIV-positive Women (the Papillon Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV - Anogenital Human Papilloma Virus Infection|HIV Infections
Interventions: BIOLOGICAL: Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase IIIB Subcutaneous Abatacept Monotherapy Study
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: abatacept|DRUG: Methotrexate (MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Influence of Liver Function on Blood Concentrations of Runcaciguat in Participants With Different Degrees of Liver Impairment
Status: TERMINATED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Runcaciguat (BAY1101042)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation and Cetuximab Plus Intratumoral EGFR Antisense DNA in Locally Advanced Head and Neck Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Squamous Cell Carcinoma|Head and Neck Cancer
Interventions: BIOLOGICAL: EGFR Antisense DNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Chatbot-Assisted Nursing Education on Perceived Burden of Care and Caregiver Stress
Status: NOT_YET_RECRUITING
Conditions: Chatbot|Anxiety|Depression|Stress|Caregivers
Interventions: OTHER: Assigned Interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure
Status: WITHDRAWN
Conditions: Hypertrophic Cardiomyopathy
Interventions: DRUG: Perhexiline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics (PK) of CTP-499
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: CTP-499|DRUG: CTP-499
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes|Obesity|Overweight or Obesity|Overweight|Cardiovascular Diseases|Chronic Kidney Disease
Interventions: DRUG: Orforglipron|DRUG: Insulin Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ocoxin®-Viusid® in Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Carcinoma|Adriamycin Toxicity|Cyclosporine Toxicity
Interventions: COMBINATION_PRODUCT: CT + Ocoxin-Viusid|COMBINATION_PRODUCT: CT + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Irinotecan,Oxaliplatin, and S1 in Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Overall Survival
Interventions: DRUG: Irinotecan,Oxaliplatin, and S1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of BA058 (Abaloparatide) Transdermal Delivery in Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Post Menopausal Osteoporosis
Interventions: DRUG: Abaloparatide Transdermal (50 mcg)|DRUG: Abaloparatide Transdermal (100 mcg)|DRUG: Abaloparatide Transdermal (150 mcg)|DRUG: Abaloparatide Injection (80 mcg)|DRUG: Abaloparatide Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isa-Pom-Dex in Elderly/Frail Subjects With RRMM
Status: RECRUITING
Conditions: Multiple Myeloma|Relapse|Refractory|Aging|Co-morbidity
Interventions: DRUG: Isatuximab|DRUG: Pomalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib 100mg qd Versus Gefitinib 250mg qd for EGFR Mutant Nsclc
Status: UNKNOWN
Conditions: Advanced Stage Non Small Cell Lung Cancer
Interventions: DRUG: Erlotinib 100mg qd|DRUG: Gefitinib 250mg qd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised, Controlled, Double-blinded, Multi-country, Multi-centre Trial to Study Growth and Health Outcomes of a New Infant- and follow-on Formula for Healthy Term Infants.
Status: NOT_YET_RECRUITING
Conditions: Baby Formula, Growth Equivalence, Neurocognitive Development, Healthy Infants
Interventions: OTHER: Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia.
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|FLT3-mutated Acute Myeloid Leukemia
Interventions: DRUG: gilteritinib|DRUG: Idarubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria
Status: COMPLETED
Conditions: Oral Bacteria Levels in the Mouth
Interventions: DRUG: Total Flavor option 1|DRUG: Total Flavor option 2|DRUG: Placebo toothpaste: Crest Cavity Protection toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Lactoferrin as an Adjunct Therapy in Patients With Hepatic Encephalopathy
Status: NOT_YET_RECRUITING
Conditions: Hepatic Encephalopathy
Interventions: DRUG: Lactoferrin Bovine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Male
Status: COMPLETED
Conditions: Gallbladder Diseases
Interventions: DRUG: Sugammadex Injectable Product|DRUG: Neostigmine Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Trial of Pamiparib With Tislelizumab in Patients With Advanced Tumours With Homologous Recombination Repair Defects
Status: RECRUITING
Conditions: Cancer
Interventions: DRUG: Pamiparib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin as Add-on to the Standard Therapy in Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Metformin & Entecavir|DRUG: Placebo & Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base
Status: UNKNOWN
Conditions: Acupuncture|Tumor, Brain|Skull Base Tumor|Cerebellopontine Angle Tumor|Complication of Treatment|Quality of Life|Neuromuscular Blockade
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monoclonal Antibody Therapy and Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: epratuzumab|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Automated Applanation Tonometry
Status: RECRUITING
Conditions: Glaucoma|Glaucoma, Suspect
Interventions: DEVICE: Standard GAT|DEVICE: Fixed force GAT|DEVICE: Upright applanating prototype|DEVICE: Supine Applanating Prototype
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PROSPective Evaluation of Fortified Eggs Related to Improvement in The Biomarker Profile for Your Health
Status: COMPLETED
Conditions: Hypercholesterolemia|Hyperlipidemia|Vitamin Deficiency|Obesity
Interventions: DIETARY_SUPPLEMENT: Fortified eggs|BEHAVIORAL: Intermittent fasting|DIETARY_SUPPLEMENT: Non-egg supplemented|BEHAVIORAL: Usual care diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of Preemptive Volume Loading to Prevent Arterial Hypotension During Induction of General Anesthesia
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: Gelatin 500 mL|DRUG: Gelatin 50 mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Sensorimotor Integration in Monogenic Parkinson-dystonia Syndromes
Status: RECRUITING
Conditions: Parkinson|Dystonia|DYT3|DYT5|PINK1 Gene Deletion|Dystonia, Familial
Interventions: DEVICE: Transcranial magnetic stimulation (TMS)|OTHER: Video-based clinical examination|OTHER: 24 hours drug withdrawal of dopaminergic medication|OTHER: Evaluation of deep brain stimulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2|Diabetes Mellitus Type 2 in Obese|Diabetes Mellitus Type 2 in Nonobese|Obesity|Cognitive Dysfunction|Metabolism Disorder
Interventions: OTHER: Skin biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial of Bio-Germanium for the Evaluation of Efficacy on Immune Function
Status: COMPLETED
Conditions: Normal Healthy Subjects
Interventions: DIETARY_SUPPLEMENT: Investigational Product (Bio-Germanium)|DIETARY_SUPPLEMENT: Control Group - Placebo Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of AAIsafeR and DDD Modes in Non-selected Patients
Status: COMPLETED
Conditions: Any Patient Who Fulfills the Inclusion Criteria to be Implanted With a Dual Chamber Pacemaker Maybe Included in the Study as Per ACC/AHA Guidelines
Interventions: PROCEDURE: Symphony Dual Chamber Rate Responsive Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rescue Progesterone Supplementation During Frozen Embryo Transfer
Status: ACTIVE_NOT_RECRUITING
Conditions: Fertility Issues|Embryo Implantation|Frozen Embryo Transfer
Interventions: DRUG: Progesterone Effervescent Vaginal Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Mobile Technology by Community-Based Health Workers to Promote Maternal and Child Health in Bihar, India
Status: COMPLETED
Conditions: Health|Pregnancy|Infant|Nutrition|Child
Interventions: BEHAVIORAL: Information Communication Technology Continuum of Care Service|OTHER: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Status: RECRUITING
Conditions: Knee Pain Chronic|Osteoarthritis, Knee|Rheumatoid Arthritis|Traumatic Arthritis|Polyarthritis|Varus Deformity|Valgus Deformity|Flexion Deformity of Knee|Avascular Necrosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of Glidescope Assisted Endotracheal Intubation on Intraocular Presure
Status: COMPLETED
Conditions: Effect of Intubation on Intraocular Pressure
Interventions: DEVICE: Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Cutera Enlighten™ Laser With Micro-Lens Array (MLA) Handpiece Attachment
Status: COMPLETED
Conditions: Scarring|Acne
Interventions: DEVICE: Enlighten™ Laser and a MLA Attachment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Bone Marrow Stem Cell Transplantation for Osteonecrosis in Sickle Cell Disease
Status: UNKNOWN
Conditions: Avascular Necrosis of Bone|Sickle Cell Disease
Interventions: PROCEDURE: Autologous bone marrow stem cell graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "How do Contrast Medias in Bone Cement Affect DXA Measurements After THR"
Status: UNKNOWN
Conditions: Primary and Secondary Osteoarthritis in Hip
Interventions: PROCEDURE: Barium Sulphate and Zirconium Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) and Tolerance Study of Natroba Topical Suspension in Pediatrics With an Active Head Lice Infestation
Status: COMPLETED
Conditions: Pediculosis
Interventions: DRUG: spinosad
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Two Approaches of Micro-osteoperforations (MOPs) During Orthodontic Canine Retraction
Status: COMPLETED
Conditions: Bimaxillary Protrusion|Angle Class II, Division 1|Dental Malocclusions
Interventions: PROCEDURE: micro-osteoperforations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy Confirmation Trial of CDP870 Without Coadministration of Methotrexate (MTX) in Japanese Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CDP870|DRUG: Placebo of CDP870
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Combination Docetaxel and Radiotherapy With or Without Cisplatin to Treat Local Advanced Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: docetaxel and cisplatin|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate Tolerability and Pharmacokinetics of TQB2858 Injection in Subjects With Advanced Malignancy
Status: UNKNOWN
Conditions: Advanced Cervical Cancer
Interventions: DRUG: TQB2858 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study of the ReGenerCell™ Autologous Cell Harvesting Device for Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: ReGenerCell™ Autologous Cell Harvesting Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
Status: TERMINATED
Conditions: Heart Failure
Interventions: PROCEDURE: Exercise training,|PROCEDURE: Muscle biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Erector Spinae Plane Block Versus Quadratus Lumborum Block for Open Renal Surgeries in Children
Status: UNKNOWN
Conditions: Postoperative Pain, Acute
Interventions: PROCEDURE: Ultrasound-guided Erector Spinae Plane Block|PROCEDURE: Ultrasound-guided Quadratus Lumborum Block|DEVICE: Ultrasound Machine|DEVICE: Echogenic needle|DRUG: Fentanyl|DRUG: Pethidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Pain, Postoperative|Total Knee Arthroplasty (TKA)
Interventions: PROCEDURE: Continuous Femoral Nerve Block|PROCEDURE: Nerve Block, Continuous Adductor Canal|PROCEDURE: Continuous Sciatic Nerve Block|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies Targeting Osteoporosis to Prevent Recurrent Fractures
Status: COMPLETED
Conditions: Osteoporosis|Fractures
Interventions: BEHAVIORAL: Patients (education, counseling) and Physicians (reminders,1-page guidelines).|BEHAVIORAL: Multifaceted intervention|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Staphylococcal Acute Post-Operative PJI Treated With 'DAIR' And Impact Of Rifampin
Status: COMPLETED
Conditions: Bone and Joint Infection|Antibiotic Resistant Staphylococcus Aureus Infection
Interventions: OTHER: Role of rifampin in staphylococcal PJI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of TRC105 Combined With Standard-Dose Bevacizumab for Advanced Solid Tumors for Which Bevacizumab is Indicated
Status: COMPLETED
Conditions: Adult Solid Tumor
Interventions: DRUG: TRC105 and Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT