pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive Keratoconus
Status: TERMINATED
Conditions: Keratoconus
Interventions: PROCEDURE: De-epithelization and therapeutic photokeratectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Gratisovir (Sofosbuvir)- Ribavirin Therapy in Pediatric Patients
Status: UNKNOWN
Conditions: Pharmacological Action
Interventions: DRUG: Sofosbuvir Oral Product|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti Xa Monitoring Low Molecular Weight Heparin on Prevention of Venous Thromboembolism
Status: RECRUITING
Conditions: Venous Thromboembolism
Interventions: DIAGNOSTIC_TEST: Peak value anti-Xa|DIAGNOSTIC_TEST: Trough value anti-Xa|DIAGNOSTIC_TEST: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Vagus Nerve Stimulation for Treating Adults With Severe Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Vagus Nerve Stimulation (VNS) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SNAKES Trial: Jelly Snakes to Prevent PONV in Kids After ENT Surgery
Status: UNKNOWN
Conditions: POSTOP NAUSEA VOMITING|Tonsillectomy|Adenoidectomy
Interventions: DIETARY_SUPPLEMENT: Jelly confectionary Snakes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparative Study to Evaluate Bone Height Gain Following Transcrestal Sinus Floor Elevation Using Specially Designed Drills Versus the Conventional Osteotome Technique.
Status: UNKNOWN
Conditions: Compromised Vertical Bone Height in the Maxillary Posterior Region
Interventions: DEVICE: Dask Advanced Sinus kit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Non Invasive Neuromodulation for Patients With Motor Control Disorders
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: Repetitive transcranial magnetic stimulation (rTMS)|OTHER: EEG guided Neurofeedback (NFB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
Status: TERMINATED
Conditions: Major Depression|Bipolar Depression
Interventions: DRUG: Ketamine|DRUG: Methohexital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle Typology and Strength Training Adaptations
Status: COMPLETED
Conditions: Muscle Fiber Type|Exercise|Training Frequency
Interventions: OTHER: Muscle typology + exercise training|OTHER: Muscle typology + training frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies
Status: RECRUITING
Conditions: Ischemic Stroke
Interventions: PROCEDURE: Remote ischemic conditioning|OTHER: standard medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Cognitive Behavioral Therapy for Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain|Musculoskeletal Pain
Interventions: OTHER: Treatment as usual (TAU)|BEHAVIORAL: Brief Cognitive Behavioral Therapy for Chronic Pain (Brief CBT-CP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery
Status: COMPLETED
Conditions: Posterior Lumbar Spinal Fusion Surgery
Interventions: DRUG: Tranexamic acid|DRUG: 0.9% NaCl (normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Lapaquistat Acetate Alone or Combined With Simvastatin in Subjects With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Lapaquistat acetate and simvastatin|DRUG: Lapaquistat acetate and simvastatin|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability Study of Bupropion HCI 150 mg Sustained-Release Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Bupropion HCI ER Tablets, 150 mg; EON Labs Inc.|DRUG: WELLBUTRIN SR (Bupropion HCI) Sustained-Release Tablets, 150 mg; GlaxoSmithKline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor Microenvironment in Gastric Cancer Patients Treated With Combined Immunotherapy and Chemotherapy
Status: RECRUITING
Conditions: Gastric Cancer|Tumor Microenvironment|Immunotherapy|Chemotherapy
Interventions: DRUG: SOX plus PD-1 inhibitor|PROCEDURE: Gastroscopic biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: S0424 - Carcinogens in Lung Tissue From Smokers (Closed to Entry as of 7/15/07) and Non-Smokers With Newly Diagnosed Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: GENETIC: chromogenic in situ hybridization|GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|OTHER: fluorescent antibody technique|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis|OTHER: matrix-assisted laser desorption/ionization time of flight mass spectrometry|OTHER: study of socioeconomic and demographic variables|PROCEDURE: study of high risk factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rehabilitation After Fast-track Total Knee Arthroplasty
Status: WITHDRAWN
Conditions: Knee Arthroplasty
Interventions: OTHER: Postoperative rehabilitation after fast-track TKA|OTHER: Postoperative rehabilitation after fast-track TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Thoracic Epidural Analgesia on Intravenous Closed-Loop Anesthesia
Status: COMPLETED
Conditions: General Anesthesia
Interventions: DRUG: remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome
Status: NOT_YET_RECRUITING
Conditions: E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic Syndrome|VEXAS|Vexas Syndrome
Interventions: DRUG: Pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Exercise and Diet Management in Vitamin D Deficient Females
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: OTHER: Home Based Physical Exercise|DIETARY_SUPPLEMENT: Vitamin D3 Supplements|OTHER: Diet Management|BEHAVIORAL: Sun Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EVALUER L'IMPACT PREDICTIF DU SCORE MEESSI POUR LA STRATIFICATION DU RISQUE DES PATIENTS ADMIS POUR INSUFFISANCE CARDIAQUE AIGUE DANS LES STRUCTURES D'URGENCES
Status: COMPLETED
Conditions: Acurate Heart Failure
Interventions: OTHER: MEESSI score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nursing Attitudes Towards SUD
Status: COMPLETED
Conditions: Substance Use Disorders|Stigma, Social
Interventions: OTHER: Unit-based "Person First" Anti-stigma Awareness Rounds|OTHER: Individual Text-based Messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cervical Softening and the Prediction of Preterm Birth
Status: RECRUITING
Conditions: Preterm Birth|Threatened Preterm Labor|Premature Birth|Premature Labor|Diagnosis|Cervical Incompetence, With Delivery|Cervical Incompetence in Pregnancy as Antepartum Condition
Interventions: DIAGNOSTIC_TEST: Measurement of cervical stiffness by Pregnolia Device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Lumbar Intervertebral Disc Degeneration
Status: WITHDRAWN
Conditions: Lumbar Intervertebral Disc Degeneration
Interventions: PROCEDURE: Autologous Adipose Tissue derived MSCs Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 20% Mannitol and 3% Hypertonic Saline for Cerebral Relaxation During Elective Supratentorial Craniotomies
Status: UNKNOWN
Conditions: Osmotherapy|Intracranial Pressure
Interventions: DRUG: 20% mannitol bolus administration|DRUG: Hypertonic saline 3% bolus administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out How YM150 is Absorbed Into and Eliminated From the Body in Healthy Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics|Healthy Male Subjects
Interventions: DRUG: YM150
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Satiety of High-protein Ramen Noodles
Status: NOT_YET_RECRUITING
Conditions: Appetitive Behavior
Interventions: OTHER: High protein ramen|OTHER: Standard ramen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: tDCS in Parkinson's Disease With Depression
Status: TERMINATED
Conditions: Depression|Parkinson's
Interventions: DEVICE: active tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety of Drug BAY1817080 at Different Doses and the Way the Body Absorbs and Eliminates the Drug in Japanese Healthy Adult Male Participants
Status: COMPLETED
Conditions: Endometriosis Related Pain|Overactive Bladder|Diabetic Neuropathic Pain|Refractory or Unexplained Chronic Cough
Interventions: DRUG: BAY1817080|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Vaccenic Acid Consumption on the Metabolism of Saturated Fatty Acids: Relationship With Cardiovascular Risk Factors
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Ruminant trans fatty acid enriched diet - lowest ratio|DIETARY_SUPPLEMENT: Ruminant trans fatty acid enriched diet - medium ratio|DIETARY_SUPPLEMENT: Ruminant trans fatty acid enriched diet - highest ratio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Advantages and Disadvantages Between Uncut Roux-en-Y Reconstruction and Billroth II Reconstruction After Laparoscopy-assisted Distal Gastrectomy for Gastric
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Uncut Roux-en-Y Reconstruction|PROCEDURE: Billroth II Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hepatocyte-specific Versus Extracellular Contrast Agents for Liver MRI: Prospective, Intra-individual Comparison of Diagnostic Performance for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Chronic Hepatitis|Liver Cirrhosis
Interventions: OTHER: hepatocyte-specific contrast agent, extracellular contrast agent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NGS Screening Protocol to Detect Mutation of KEAP1 or NRF2/NFE2L2 Genes for the KEAPSAKE (CX-839-014) Trial
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer|Non-squamous Non-small-cell Lung Cancer|Non-Squamous Non-Small Cell Neoplasm of Lung|KEAP1 Gene Mutation|NRF2 Mutation|NFE2L2 Gene Mutation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label Pharmacokinetics (PK)/Safety Study of Luliconazole Solution, 10% in Distal Subungual Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: Luliconazole Solution, 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Effects on Cognitive Function Following Colonoscopy
Status: COMPLETED
Conditions: Digestive System Diseases|Disorientation
Interventions: DRUG: Fentanyl|DRUG: Alfentanil|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Clinical Study to Compare Efficacy and Safety of Casirivimab and Imdevimab Combination, Remdesivir and Favipravir in Hospitalized COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Casirivimab and Imdevimab Drug Combination|DRUG: Remdesivir|DRUG: Favipiravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Renal Osteodystrophy: An Individual Management Approach
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Alendronate|DRUG: Teriparatide|DRUG: Cinacalcet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer
Status: SUSPENDED
Conditions: Colorectal Cancer Metastatic|Colon Cancer|Metastatic Colorectal Cancer|Rectal Cancer|Liver Metastasis Colon Cancer|Colo-rectal Cancer|Colorectal Adenocarcinoma|Colorectal Neoplasms|Liver Metastases|Colorectal Carcinoma
Interventions: DRUG: Durvalumab|RADIATION: Yttrium-90 RadioEmbolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation for Painful Diabetic Neuropathy
Status: TERMINATED
Conditions: Diabetic Neuropathy|Pain|Peripheral Neuropathy
Interventions: DEVICE: Precision Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone and Postoperative Delirium
Status: TERMINATED
Conditions: Delirium|Postoperative Cognitive Dysfunction
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Vegetarian Diet on Patients With Metabolic Associated Fatty Liver Disease
Status: RECRUITING
Conditions: Metabolism and Nutrition Disorder|Liver Diseases|Obesity|Diet, Healthy
Interventions: BEHAVIORAL: dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-response of the Effects of Exendin-9,39 on GI Symptoms and Food Intake
Status: COMPLETED
Conditions: Obesity|Diabetes|Roux-en-Y Gastric Bypass
Interventions: DRUG: Exendin-9,39|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Nd-YAG Laser on Hypertrophic Scar
Status: COMPLETED
Conditions: Hypertrophic Scar
Interventions: PROCEDURE: Nd- YAG laser at 532nm wavelength
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of EN3835 in the Treatment of Cellulite in Women
Status: COMPLETED
Conditions: Edematous Fibrosclerotic Panniculopathy (Cellulite)
Interventions: BIOLOGICAL: EN3835|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sedation for Non-invasive Ventilation in Blunt Chest Trauma
Status: COMPLETED
Conditions: Chest Trauma
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Ketamine Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sildenafil Versus Placebo in Chronic Heart Failure
Status: UNKNOWN
Conditions: Heart Failure|Pulmonary Hypertension
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Impact of Hypothermic Machine Perfusion in Renal Transplant Recipients
Status: UNKNOWN
Conditions: Delayed Function of Renal Transplant
Interventions: DEVICE: Kidney Transporter machines|DEVICE: cold storage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial
Status: RECRUITING
Conditions: Lung Carcinoma|Stage I Lung Cancer AJCC v8|Stage IA1 Lung Cancer AJCC v8|Stage IA2 Lung Cancer AJCC v8|Stage IA3 Lung Cancer AJCC v8|Stage IB Lung Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage IIA Lung Cancer AJCC v8|Stage IIB Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IIIC Lung Cancer AJCC v8
Interventions: DRUG: Canakinumab|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Performance Evaluation of Artificial Intelligence Assisted Diabetic Retinopathy Grading in the Leuven University Hospital: Can Technology Improve the Resident?
Status: UNKNOWN
Conditions: To Evaluate the Added Value of the Use of Artificial Intelligence in the Diagnosis of Referable Diabetic Retinopathy in a Teaching Hospital Setting
Interventions: DEVICE: MONA algorithm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Combination Efficacy Study in Africa of Two DNA-MVA-Env Protein or DNA-Env Protein HIV-1 Vaccine Regimens With PrEP
Status: ENROLLING_BY_INVITATION
Conditions: HIV Infections
Interventions: BIOLOGICAL: Vaccine Group A: DNA-HIV-PT123 and AIDSVAX® B/E (weeks 0,4,24,48)|BIOLOGICAL: Vaccine Group B: DNA-HIV-PT123 and CN54gp140+MPLA-L (weeks 0,4), then MVA and CN54gp140+MPLA-L (weeks 24,48)|BIOLOGICAL: Vaccine Group C: Saline placebo (weeks 0,4,24,48)|DRUG: Control PrEP:TDF/FTC once daily (weeks 0-26)|DRUG: Experimental PrEP:TAF/FTC once daily (weeks 0-26)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SINGLE SHOT CHAMPION
Status: ACTIVE_NOT_RECRUITING
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: PVI using the Arctic Front Cryoballoon (Medtronic)|DEVICE: PVI using FARAPULSE Pulsed Field Ablation (Boston Scientific)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AI as an Aid for Weekly Symptom Intake in Radiotherapy
Status: NOT_YET_RECRUITING
Conditions: Radiotherapy Side Effect|Pelvic Cancer|Patient
Interventions: OTHER: Generative Artificial Intelligence|OTHER: Standard weekly symptom intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study in Preterm Neonates With Respiratory Distress Syndrome (RDS) Comparing CUROSURF® Administration Through Less Invasive Surfactant Administration (LISA) and Conventional Administration
Status: TERMINATED
Conditions: Respiratory Distress Syndrome (RDS)
Interventions: COMBINATION_PRODUCT: LISA combination product (Curosurf+catheter CHF6440)|DRUG: Curosurf through conventional administration (endotracheal tube)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Indocyanine Green Lymphangiography in Identifying Thoracic Duct During Neck Surgery
Status: COMPLETED
Conditions: Neck Dissection|Radical Lymph Node Dissection
Interventions: OTHER: Indocyanine Green Solution|PROCEDURE: Lymphangiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Single Dose Intranasal Insulin On Cognitive Function
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Placebo|DRUG: Insulin (Humulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Systematic Search for Primary Immunodeficiency in Adults With Infections
Status: TERMINATED
Conditions: Complement Deficiency|Antibody Deficiency|Chronic Sinus Infection|Meningitis, Bacterial|Pneumonia, Bacterial|Otitis Media|Streptococcal Infection|Neisseria Infections|Haemophilus Influenza|Pneumococcal Infections
Interventions: BIOLOGICAL: Immunological diagnosis tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Benefits of Exercise Training in Head and Neck Cancer Patients Undergoing Organ-Preserving Definitive Therapy
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: PROCEDURE: Resistance Exercise Training (RET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Volunteers to Assess the Pharmacokinetics (PK) of Digoxin Administered Alone and in Combination With Vandetanib
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Digoxin|DRUG: Vandetanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Feasibility of Combined Trigeminal and Occipital Transcutaneous Nerve Stimulation (CTO-TNS) in Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Neurolief system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sodium Rinsing Fluid on Blood Pressure and Interdialytic Weight Change in Hemodialysis Patients
Status: UNKNOWN
Conditions: End-Stage Kidney Disease|Hemodialysis
Interventions: DRUG: Dextrose 5%|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Iron Substitution After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Haemodynamic Rebound
Interventions: DRUG: Hemoboost|DRUG: Kräuterblut|DRUG: Ferrofumerat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of the Irradiance Level of Phototherapy for Neonatal Jaundice
Status: TERMINATED
Conditions: Neonatal Jaundice
Interventions: OTHER: High irradiance level of phototherapy|OTHER: Low irradiance level of phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Performance Evaluation Study of the Xpert® Bladder Cancer Monitor Test.
Status: COMPLETED
Conditions: Non-Invasive Bladder Urothelial Carcinoma|Non-Invasive Bladder Papillary Urothelial Carcinoma, Low Grade|Non-Invasive Bladder Papillary Urothelial Carcinoma, High Grade
Interventions: OTHER: Xpert® Bladder Cancer Monitor Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Gingival Fissures Associated With Soft and Medium Toothbrushes
Status: COMPLETED
Conditions: Gingival Recession|Gingival Abrasion|Wounds and Injuries
Interventions: DEVICE: Toothbrush type
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery
Status: COMPLETED
Conditions: End Stage Renal Disease|Hemodialysis Complication
Interventions: DRUG: Propofol|DEVICE: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preconception Lifestyle Interventions to Improve Future Metabolic Health (Before the Beginning)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gestational Diabetes
Interventions: BEHAVIORAL: time-restricted eating|BEHAVIORAL: high intensity exercise|OTHER: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
Status: ENROLLING_BY_INVITATION
Conditions: Bullous Pemphigoid
Interventions: BIOLOGICAL: efgartigimod PH20 SC|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Tolterodine, Pregabalin and a Tolterodine - Pregabalin Combination for the Treatment of Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Tolterodine & Pregabalin|DRUG: Tolterodine|DRUG: Placebo|DRUG: Tolterodine & Pregabalin|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thalidomide, Celecoxib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Malignant Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: celecoxib|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COntinue the SaMe Systemic Therapy After Local Ablative Therapy for Oligo Progression in Metastatic Breast Cancer - the COSMO Study
Status: RECRUITING
Conditions: Breast Cancer Invasive|Metastatic Cancer|Oligoprogressive
Interventions: PROCEDURE: Surgery|RADIATION: Radiotherapy|OTHER: Radiofrequent ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Adjunctive Therapy of Emdogain®FL in Non-surgical Periodontal Treatment
Status: NOT_YET_RECRUITING
Conditions: Periodontitis
Interventions: DEVICE: Enamel matrix derivate|PROCEDURE: Non-surgical periodontal treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resiliency Among Older Adults Receiving Lung Cancer Treatment
Status: COMPLETED
Conditions: Advanced Lung Carcinoma|Extensive Stage Lung Small Cell Carcinoma|Stage IIIA Lung Cancer AJCC v8|Stage IIIB Lung Cancer AJCC v8|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8|Unresectable Lung Carcinoma|Unresectable Lung Non-Small Cell Carcinoma
Interventions: PROCEDURE: Physical Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Relaxation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Proof of Concept Study of Intravenous Sodium Nitroprusside in Adults With Symptomatic Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: sodium nitroprusside|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide/INOpulse DS for Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|Pulmonary Hypertension
Interventions: COMBINATION_PRODUCT: Inhaled Nitric Oxide 0.025 mg/kg IBW/hr delivered via INOpulse DS Device|COMBINATION_PRODUCT: Placebo delivered via INOpulse DS Device|COMBINATION_PRODUCT: Inhaled nitric oxide 0.075 mg/kg IBW/hr delivered via INOpulse DS Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intraperitoneal Versus Intravenous Lidocaine for Postcesarean Pain Relief
Status: COMPLETED
Conditions: Postcesarean Pain Relief
Interventions: DRUG: Intravenous normal saline|DRUG: Intraperitoneal normal saline|DRUG: Intraperitoneal Lidocaine|DRUG: Intravenous Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess If 10 mg Vardenafil (BAY38-9456) Taken Twice Daily For 6 Weeks Has An Effect On Bladder Function
Status: COMPLETED
Conditions: Overactive Bladder|Detrusor Overactivity
Interventions: DRUG: Vardenafil HCl (Levitra, BAY38-9456)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real World Experience With Mogamulizumab in the Treatment of Cutaneous T-cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Cutaneous T Cell Lymphoma|Cutaneous T-Cell Lymphoma/Mycosis Fungoides|Cutaneous T-Cell Lymphoma/Sezary Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Tendon Transfer, Botox Injections and Ongoing Treatment in Hemiplegic Cerebral Palsy
Status: TERMINATED
Conditions: Cerebral Palsy
Interventions: PROCEDURE: Upper Extremity Tendon transfer|PROCEDURE: Botulinum Toxin injections in Upper Extremity|PROCEDURE: Regularly ongoing therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Patient-Centered Versus Physician-Centered Counseling MidUrethral Sling Videos
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Satisfaction
Interventions: BEHAVIORAL: Patient-Centered Counseling Video|BEHAVIORAL: Physician Counseling Video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Self Correction Exercises for Idiopathic Scoliosis Among Adolescents. A Randomised Controlled Trial
Status: COMPLETED
Conditions: Scoliosis Idiopathic
Interventions: OTHER: Self Correction exercises|DEVICE: orthotic devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Topical Tacrolimus 0.05% in the Treatment of Ocular Graft-Versus-Host Disease
Status: COMPLETED
Conditions: Ocular GVHD
Interventions: DRUG: Tacrolimus|DRUG: Methylprednisolone Sodium Succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anterior Insula Regulation and Pain Empathy
Status: COMPLETED
Conditions: Anterior Insula Activity During Regulation|Empathic Responses After Anterior Insula Regulation
Interventions: DEVICE: real-time fMRI neurofeedback training running on Turbo Brain voyager (TBV) 3.2 (Brain Innovation, Maastricht, The Netherlands)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between the Right Lateral Decubitus and the Left Lateral Decubitus as Starting Position in Colonoscopy
Status: UNKNOWN
Conditions: Colonoscopy
Interventions: OTHER: Left Sided Colonoscopy|OTHER: Right Sided Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Remote Monitoring With Health-Coaching to Improve Quality of Life in Older Patients With Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma
Interventions: BEHAVIORAL: Supportive Care (home-based physical activity)|OTHER: Exercise Intervention|OTHER: telephone interview|OTHER: Remote Monitoring|PROCEDURE: Patient Monitoring|OTHER: Questionnaire Administration|OTHER: Electronic Health Record Review
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
Status: RECRUITING
Conditions: Non-alcoholic Steatohepatitis
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine by Laypersons
Status: UNKNOWN
Conditions: Venomous Snakebites|Local Anesthesia|Painless Injection|Regional Anesthesia|Dermatologic Surgery|Cutaneous Pain|Musculoskeletal Pain
Interventions: DRUG: Tumescent Lidocaine and Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Therapy on Wrist and Hand Functions in Spastic Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke|Spasticity|Shock Wave
Interventions: DEVICE: Extracorporeal shock wave therapy|OTHER: Conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve
Status: UNKNOWN
Conditions: Pulmonary Valve; Failure|Percutaneous Pulmonary Valve Implantation|Infective Endocarditis|Congenital Heart Disease
Interventions: DEVICE: Percutaneous pulmonary valve implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
Status: SUSPENDED
Conditions: Early Breast Cancer
Interventions: DRUG: Ribociclib|DRUG: Letrozole|DRUG: Ansastrozole|DRUG: Goserelin|DRUG: Leuprolide|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell Leukemia
Status: COMPLETED
Conditions: Leukemia, T-Cell
Interventions: DRUG: forodesine hydrochloride (BCX-1777)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients
Status: COMPLETED
Conditions: Pain|Opioid Use, Unspecified, Uncomplicated
Interventions: DRUG: Placebo infusion of .9 normal saline|DRUG: administration of magnesium sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: ResA|DIETARY_SUPPLEMENT: Resveratrol|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pre-consultation Compassion Among Patients Referred to a Cancer Center
Status: COMPLETED
Conditions: Cancer|Anxiety|Compassion|Empathy
Interventions: OTHER: Enhanced compassion video|OTHER: Standard introduction video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Gemcitabine and Cisplatin Followed by Chemoradiation for Resected Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of FMT on the Phenome in Patients With NAFLD and Fibrosis
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Fecal Microbiota Transplantation
Interventions: OTHER: Faecal microbiota transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: First Time in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of GSK3389404 in Healthy Subjects
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: GSK3389404|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Pineapple Juice on the Pharmacokinetics of Celecoxib and Montelukast in Humans
Status: COMPLETED
Conditions: Food-drug Interaction
Interventions: DRUG: Celecoxib 100mg|DRUG: Montelukast 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation With Flaxseed Oil in the State of Rio de Janeiro
Status: UNKNOWN
Conditions: Hypertension|Dyslipidemia
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Flaxseed Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: MK-3475 and Gemcitabine in Non-Small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: MK-3475|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Compare the Efficacy and Safety of a Novel Medicine (NNC0268-0965) With Insulin Glargine
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: NNC0268-0965|DRUG: Insulin glargine|DRUG: Placebo (NNC0268-0965)|DRUG: Placebo (insulin glargine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures
Status: WITHDRAWN
Conditions: Endoscopic Retrograde Cholangiopancreatography|Klatskin Tumor
Interventions: DEVICE: Endoscopic scissors|DEVICE: Biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up of Indirect Restorations Luted With Different Adhesive Resin Cement
Status: COMPLETED
Conditions: Dental Restoration Failures
Interventions: PROCEDURE: To evaluate the clinical performance of indirect resin composite restorations, which were luted with two different resin cement, in posterior teeth for up to 2 years.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multi-site Feasibility and Acceptability of a Faith-based Mind-body Intervention for Black Adults
Status: RECRUITING
Conditions: Psychosocial|Mind-body
Interventions: BEHAVIORAL: Harmony & Health Intervention|BEHAVIORAL: Attention Control|DEVICE: Fitbit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sirolimus & Mycophenolate Mofetil as GVHD Prophylaxis in Myeloablative, Matched Related Donor HCT
Status: COMPLETED
Conditions: Leukemia|Lymphoma, Non-Hodgkin|Hematologic Diseases|Acute GVHD
Interventions: DRUG: Sirolimus|DRUG: MMF|DRUG: BCNU|DRUG: VP-16|DRUG: CY|DRUG: FTBI|DRUG: BU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FIbromyalgia anD GenetIcs Subgroups (FIDGIS)
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Electrophysiological measurement of reflex nociceptive flexion threshold (RIII reflex) using Nicolet Vicking device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Brexpiprazole for the Treatment of Patients With Agitation Associated With Dementia of the Alzheimer's Type
Status: COMPLETED
Conditions: Agitation Associated With Dementia of the Alzheimer's Type
Interventions: DRUG: Brexpiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Azithromycin in the Management of Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Azithromycin|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Talimogene Laherparepvec With Pembrolizumab in Melanoma Following Progression on Prior Anti-PD-1 Based Therapy (MASTERKEY-115) (Mk-3475-A07/KEYNOTE-A07).
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Talimogene laherparepvec|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab, Oxaliplatin, and Docetaxel in Treating Patients With Locally Advanced Unresectable or Metastatic Stomach or Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: BIOLOGICAL: Bevacizumab|DRUG: Docetaxel|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Relacorilant (CORT125134) in Combination With Nab-paclitaxel in Participants With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Relacorilant with nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transthoracic Incremental Monophasic Versus Biphasic by Emergency Responders (TIMBER)
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DEVICE: Defibrillation (biphasic versus monophasic shock)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CCEF in the Treatment of Acute VFFs: Randomized Controlled Trial
Status: COMPLETED
Conditions: Vertebral Fracture|Osteoporotic Fractures
Interventions: DEVICE: Capacitive Coupled Electric Fields (CCEF)|OTHER: Calssic clinical protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Multiple Subcutaneous (s.c.) Injections of SHR-1314 in Adults With Moderate-to-severe Plaque Psoriasis
Status: UNKNOWN
Conditions: Moderate-to-severe Plaque Psoriasis
Interventions: BIOLOGICAL: SHR-1314
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Retrolaminar and Medial Branch Block in Cervical Facet Joint Arthropathy
Status: COMPLETED
Conditions: Joint Pain
Interventions: OTHER: Retrolaminar block|OTHER: Medial Branch Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Extension of Analgesia by Combined Injection of Dexamethasone and Dexmedetomidine After Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Dexmedetomidine|DRUG: Ropivacaine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT