pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Computerized Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lipid Mediators in Colonic Biopsies as Biomarkers of Disease Activity of Inflammatory Bowel Diseases
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases|Colitis, Ulcerative|Crohn Disease
Interventions: OTHER: Colonic Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction|Acute Postoperative Pain|Chronic Postsurgical Pain
Interventions: BEHAVIORAL: Measurement of cognitive function|PROCEDURE: Thoracic paravertebral block|BEHAVIORAL: The assessment of cognitive function
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study of DRL-17822, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Patients With Abnormal Cholesterol Levels
Status: COMPLETED
Conditions: Type II Hyperlipidemia
Interventions: DRUG: DRL-17822 or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Analgesic Action of Pregabalin, Duloxetine and Tramadol in Patients With Different Neuropathic Pain Phenotypes
Status: RECRUITING
Conditions: Neuropathic Pain
Interventions: DRUG: Pregabalin group|DRUG: Duloxetine group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ephedrine for the Treatment of Congenital Myasthenia
Status: UNKNOWN
Conditions: Myasthenic Syndromes, Congenital
Interventions: DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress and Neurofeedback in Anorexia Nervosa
Status: ACTIVE_NOT_RECRUITING
Conditions: Anorexia Nervosa|Atypical Anorexia Nervosa
Interventions: BEHAVIORAL: Negative Affect Task
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: TACE Combined With Lenvatinib and MWA in the Treatment of Locally Advanced Large Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Liver Tumor
Interventions: DRUG: TACE combined with Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19
Status: RECRUITING
Conditions: SARS-CoV Infection|COVID-19
Interventions: DRUG: Mitoquinone/mitoquinol mesylate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-eluting Balloon Versus Drug-eluting Stent for High Bleeding Risk Angioplasty
Status: TERMINATED
Conditions: High Bleeding Risk|Coronary Artery Disease (CAD)|Percutaneous Coronary Intervention (PCI)
Interventions: DEVICE: Drug Eluting Balloon (DEB)|DEVICE: Drug Eluting Stents (DES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients
Status: UNKNOWN
Conditions: Major Depression
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ResCure™ to Treat COVID-19 Infection
Status: WITHDRAWN
Conditions: COVID|Covid-19|Corona Virus Infection|Sars-CoV2|Coronavirus-19|SARS Pneumonia|SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere
Interventions: BIOLOGICAL: ResCure™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Bioequivalence of Tiotropium Bromide Inhalation Powder in Healthy Adult Participants Under Fasting Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Tiotropium Bromide Inhalation Powder|DRUG: Spiriva®Handihaler®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Subcutaneous Immunotherapy With Dermatophagoides Pteronyssinus in Local Allergic Rhinitis
Status: COMPLETED
Conditions: Local Allergic Rhinitis
Interventions: BIOLOGICAL: Pangramin Plus D. pteronyssinus|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intra-operative Ketorolac on Hematoma Rates in Breast Reduction Surgery
Status: RECRUITING
Conditions: Hematoma Postoperative
Interventions: DRUG: Ketorolac|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy 、Safety and PK of SHR-1314 in Patients With Moderate-to-Severe Plaque Psoriasis
Status: UNKNOWN
Conditions: Moderate-to-Severe Plaque Psoriasis
Interventions: DRUG: SHR-1314|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy
Status: TERMINATED
Conditions: Progressive Supranuclear Palsy|Spinal Cord Stimulation
Interventions: PROCEDURE: Spinal Cord Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appropriateness of Carpal Tunnel Syndrome Management Compared With the AAOS Appropriate Use Criteria
Status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: Comparing the appropriateness of our practice and the usability of the AUC through comparing the actual management provided at our institution with that recommended by the AUC.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Imatinib Mesylate in Treating Patients With Myelofibrosis
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia|Essential Thrombocythemia|Polycythemia Vera|Primary Myelofibrosis
Interventions: DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Anti-Cancer Drugs Erdafitinib With or Without Atezolizumab in Patients With Localized Bladder Cancer Not Able to Receive Cisplatin Chemotherapy, NERA Trial
Status: WITHDRAWN
Conditions: Bladder Carcinoma|Bladder Urothelial Carcinoma|Muscle Invasive Bladder Carcinoma|Renal Pelvis and Ureter Urothelial Carcinoma|Stage II Bladder Cancer AJCC v8|Stage III Bladder Cancer AJCC v8|Stage IVA Bladder Cancer AJCC v8|Urothelial Carcinoma
Interventions: BIOLOGICAL: Atezolizumab|PROCEDURE: Biospecimen Collection|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Cystoscopy|DRUG: Erdafitinib|PROCEDURE: Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block on Stress Response
Status: COMPLETED
Conditions: Gastrostomy
Interventions: OTHER: Transversus abdominis plane block|OTHER: Epidural anesthesia|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluorouracil, Gemcitabine, and Radiation Therapy in Treating Patients With Cancer of the Pancreas
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: fluorouracil|DRUG: gemcitabine hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Efficacy and Safety of CC-5013 vs. Placebo in Subjects With Metastatic Malignant Melanoma.
Status: COMPLETED
Conditions: Melanoma|Neoplasm Metastasis
Interventions: DRUG: CC-5013
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Bileacid Malabsorption and GLP-1 Secretion
Status: COMPLETED
Conditions: Bileacid Malabsorption
Interventions: DRUG: "cholestagel®" (Colesevelam)|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Appropriate Dosage of Vasopressor in Neonates and Infants
Status: NOT_YET_RECRUITING
Conditions: Hypotension|Neonatal Hypotension|Intraoperative Complications
Interventions: DRUG: EPHEDrine Hydrochloride 5 mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Nutritional Supplementation on Nutritional Status & Rehospitalization in Malnourished Elderly Patients
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Nutrient-dense drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Auricular Vagus Nerve Stimulation in Painful and Inflammatory Erosive Hand Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis|Musculoskeletal Pain|Erosive Osteoarthritis
Interventions: DEVICE: Active VAGUSTIM device|DEVICE: Sham VAGUSTIM device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PK Comparison of 6mg and 12mg EMSAM in Elderly vs. Non-Elderly
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: EMSAM (Selegiline Transdermal System) 6mg|DRUG: EMSAM (Selegiline Transdermal System) 12mg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Oral Carnitine for Cramps in Pregnancy
Status: TERMINATED
Conditions: Muscle Cramp
Interventions: DIETARY_SUPPLEMENT: L-Carnitine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Educational Methods for Teaching Peripheral Blood Smears
Status: COMPLETED
Conditions: Hematologic Diseases
Interventions: OTHER: Case vignette-based teaching of cell recognition|OTHER: Compare-contrast basic science teaching of cell recognition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluate Pharmacokinetics Of Two Different Pharmaceutical Oral Formulations Of Alprazolam And A Clonazepam Tablet In Mexican Healthy Population
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Alprazolam|DRUG: Alprazolam XR|DRUG: Clonazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of the Effect of 3HP vs Periodic 3HP vs 6H in HIV-Positive Individuals
Status: COMPLETED
Conditions: Tuberculosis|HIV
Interventions: DRUG: rifapentine + isoniazid|DRUG: Isoniazid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
Status: RECRUITING
Conditions: Opioid Use Disorder|Opioid Misuse|Chronic Pain
Interventions: BEHAVIORAL: Implementation Strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7759065 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Solid Tumour
Interventions: DRUG: RO7759065|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor Stem Cell Transplant in Treating Patients With Previously Treated Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: busulfan|DRUG: cyclophosphamide|BIOLOGICAL: Stem cell infusion|RADIATION: Total body irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abraxane With Anti-PD1/PDL1 in Patients With Advanced Urothelial Cancer
Status: COMPLETED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breaking Sitting With High-intensity Interval Training for Brain Health
Status: RECRUITING
Conditions: Aging
Interventions: BEHAVIORAL: High-Intensity Interval Training (HIIT) Breaks to Sitting|BEHAVIORAL: Light-Intensity Interval Training (LIIT) Breaks to Sitting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: mGain - sEMG-based Gamified Therapy for Improved Upper Limb Rehabilitation
Status: RECRUITING
Conditions: Upper Limb Weakness Due to Central Neurologic Injury|Upper Limb Weakness Due to Peripheral Neurologic Injury|Upper Limb Weakness Due to Nerve Reconstruction|Upper Limb Weakness Due to Tendon Transfer Surgery|Stroke|Upper Limb Amputation
Interventions: DEVICE: mGain system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Communicate Study Partnership
Status: RECRUITING
Conditions: Aboriginal Health|Cultural Safety|Access to Interpreters|Healthcare Provider Training
Interventions: BEHAVIORAL: Interventions to transform the culture of healthcare systems to achieve excellence in providing culturally safe care for First Nations peoples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TC Avastin. ICORG 08-10, V6
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: cyclophosphamide|DRUG: docetaxel|PROCEDURE: adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Evaluating the Safety and Efficacy of a New Hard-on-Hard Total Hip Replacement System
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthritis, Degenerative
Interventions: DEVICE: ODH Hip System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of IRD (Ixazomib, Lenalidomide, Dexamethasone) Post Autologous Stem Cell Transplantation Followed by Maintenance Ixazomib or Lenalidomide for Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Ixazomib|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Universal CAR-T Cells (BRL-301) in Refractory Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: BIOLOGICAL: BRL-301
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Attenuation of Postprandial Inflammatory Processes in Alzheimer's Disease Patients by Consumption of Pomace Oil
Status: RECRUITING
Conditions: Alzheimer's Disease
Interventions: DIETARY_SUPPLEMENT: Consumption of olive pomace olive oil by alzheimer's patients|DIETARY_SUPPLEMENT: Consumption of high-oleic sunflower oil by alzheimer's patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Usefulness of Antimicrobial Prophylaxis in Children With Isolated Vesico-Ureteral Reflux.
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: PROCEDURE: Antimicrobial prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetics and Pharmacodynamics of Beta-lactams of Interest in Adult Patients From Intensive Care Units
Status: UNKNOWN
Conditions: Pharmacokinetics|Anti-Bacterial Agents|Infection, Bacterial|Infections, Respiratory|Infection|Drug Monitoring
Interventions: DRUG: blood sampling|DRUG: Tissue sampling (lung)|DRUG: Collection of fluid samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Pilates Method and Aerobic Training in Hypertensive Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Aerobic Exercise|OTHER: Pilates
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Xanthohumol on Metabolic Syndrome Progression
Status: UNKNOWN
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: XAN|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palliative RadIotherapy of Multiple Metastatic Sites Before First Line of Systemic Therapy With Immune Checkpoint Inhibitors and Chemotherapy in Metastatic Non-Small-Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Metastatic Lung Non-Small Cell Carcinoma|Non Small Cell Lung Cancer
Interventions: RADIATION: Palliative Radiotherapy: 5 x 4Gy|DRUG: chemotherapy + immune checkpoint inhibitors
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space("ICE PLS")
Status: TERMINATED
Conditions: Cancer|Pleural Neoplasms
Interventions: DEVICE: CryoSpray Ablation (TM) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Severe Anaemia in Gambian Children
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: sulfadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Wearing Operation Gown With Cartoon Characters on Reducing Preoperative Anxiety in Children: Randomized Controlled Study
Status: NOT_YET_RECRUITING
Conditions: Anxiety, Preoperative
Interventions: OTHER: The hospital gown with cartoon characters
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Randomized, Double-blind, Placebo-controlled Study of Delandistrogene Moxeparvovec (SRP-9001) for Duchenne Muscular Dystrophy (DMD)
Status: COMPLETED
Conditions: Muscular Dystrophy, Duchenne
Interventions: GENETIC: delandistrogene moxeparvovec|GENETIC: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparability of Bispectral Index and Neurosense During Anesthesia
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: propofol, remifentanil, atracurium|DRUG: propofol, remifentanil, atracurium, sevoflurane|DEVICE: EEG monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy of Low-dose Acetylsalicylic Acid on Diarrhea Induced by Anti-cancer Targeted Therapies.
Status: WITHDRAWN
Conditions: Cancer
Interventions: DRUG: Acetylsalicylic acid + loperamide|DRUG: diosmectite + loperamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban Plus ASA in Embolic Stroke of Undetermined Source(AREST-ESUS)
Status: COMPLETED
Conditions: Stroke|Prevention
Interventions: DRUG: Rivaroxaban 2.5 Mg Oral Tablet|DRUG: Rivaroxaban placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Chronic Phase Who Are Refractory to Imatinib Mesylate (Gleevec)
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: decitabine (5-aza-2'deoxycytidine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: State of the Art Photon Therapy Versus Particle Therapy for Recurrent Head & Neck Tumors; a Planning Study
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of Head and Neck
Interventions: RADIATION: Photon therapy versus proton therapy|RADIATION: Photon therapy versus C-ion therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HuoXin Pills Intervention on Patients With Coronary Heart Disease After Drug-Coated Balloon Implantation
Status: RECRUITING
Conditions: Coronary Heart Disease|Medicine, Chinese Traditional
Interventions: DRUG: Yuekang Huoxin Pills (concentrated pills)|DRUG: Yuekang Huoxin Pills (concentrated pills)simulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Trial Comparing EC-wPversus EP-wP as Adjuvant Therapy for Operable Breast Cancer Patients Less Than 40 Years Old
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Epirubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the MacGrath MAC Videolaryngoscope and the MacIntosh Laryngoscope for Oro-tracheal Intubation for Patients With Less Than 2 Criteria of Difficult Intubation in Elective Surgery.
Status: COMPLETED
Conditions: Laryngoscopy
Interventions: DEVICE: Laryngoscopy with Mac Grath|DEVICE: direct laryngoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transurethral Myoblast Injection for Urinary Incontinence in Children With Bladder Exstrophy
Status: UNKNOWN
Conditions: Urinary Incontinence
Interventions: PROCEDURE: Myoblast Transplantation|BIOLOGICAL: Neonatal Cystourethroscope Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ⅱ Study of Neoadjuvant Chemotherapy Followed by Concurrent Chemoradiation for Stage ⅣAB Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: docetaxel, cisplatin, fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroke Prophylaxis of AF-patients: Real-life Effectiveness and Safety of Novel Anticoagulants Compared to VKA
Status: COMPLETED
Conditions: Atrial Fibrillation|Stroke Prophylaxis
Interventions: DRUG: vitamin-k-antagonists|DRUG: Novel oral anticoagulants
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Carbohydrate Rich Drink Reduces Pre-endoscopic Discomfort for Patients Going for Elective Endoscopic Procedures
Status: COMPLETED
Conditions: Hunger|Depression|Anxiety|Vomiting|Abdominal Pain|Thirst|Fatigue|Lethargy
Interventions: OTHER: Nestle Preload|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: dexamethasone|DRUG: floxuridine|DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: laparotomy|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Eculizumab in Shiga-Toxin Producing Escherichia Coli Hemolytic-Uremic Syndrome (STEC-HUS)
Status: COMPLETED
Conditions: Shiga-like Toxin-producing Escherichia Coli
Interventions: DRUG: Eculizumab (Soliris®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Basis for Prediction of Non-responders to Dietary Plant Sterol Intervention
Status: TERMINATED
Conditions: Hypercholesterolemia|Cardiovascular Disease
Interventions: OTHER: Plant sterols|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial of the Impact of Speed and Conventional Sintering on Ultra-thin, Highly Translucent, Multilayered Zirconia Laminate Restorations
Status: RECRUITING
Conditions: Dental Veneers
Interventions: OTHER: Laminate veneers with speed sintering|OTHER: Laminate veneers with conventional sintering
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study)
Status: TERMINATED
Conditions: Breast Neoplasms|BRCA 1 Gene Mutation|BRCA 2 Gene Mutation
Interventions: DRUG: talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Zemplar Capsule in Reducing Serum iPTH Levels in Chronic Kidney Disease Subjects (Daily Dosing)
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic
Interventions: DRUG: paricalcitol capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Relative Bioavailability, Proton Pump Inhibitor (PPI) (Rabeprazole) Effect, Food Effect and Particle Size Effect of New Acalabrutinib Tablet in Healthy Subjects
Status: COMPLETED
Conditions: Bioavailability|B-cell Lymphoid Cancer
Interventions: DRUG: Treatment A- Part 1|DRUG: Treatment B- Part 1|DRUG: Treatment C - Part 1|DRUG: Treatment D- Part 1|DRUG: Treatment A-Part 2|DRUG: Treatment B - Part 2|DRUG: Treatment C - Part 2|DRUG: Treatment D - Part 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Assessment of Infrared Treatment for Crohn's Disease
Status: RECRUITING
Conditions: IBD|Inflammatory Bowel Diseases|Crohn Disease
Interventions: DEVICE: photobiomodulation treatment in the infrared (IR) range.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab as Front-Line Therapy in Treating Elderly Participants With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Cardiovascular Complication
Interventions: DRUG: Multiple cardiovascular drugs related to "Golden Triangle"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension to Study MALARIA-055 PRI (NCT00866619) to Evaluate the Long-term Efficacy, Safety and Immunogenicity of GSK Biologicals' Candidate Malaria Vaccine in Infants and Children in Africa
Status: COMPLETED
Conditions: Malaria
Interventions: PROCEDURE: Blood sampling|BIOLOGICAL: Malaria Vaccine 257049 (MALARIA-055 PRI)|BIOLOGICAL: Meningococcal C Conjugate Vaccine (MALARIA-055 PRI)|BIOLOGICAL: Cell-culture rabies vaccine (MALARIA-055 PRI)|BIOLOGICAL: TritanrixHepB/Hib (MALARIA-055 PRI)|BIOLOGICAL: Polio Sabin Oral Polio Vaccine (GSK) (MALARIA-055 PRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Joint Crisis Plan Effectiveness in Preventing Relapses in Schizophrenia and Schizoaffective Disorder
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: PROCEDURE: SOS Plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Proof of Concept Study of SAR443122 in Patients With Cutaneous Lupus Erythematosus
Status: COMPLETED
Conditions: Cutaneous Lupus Erythematosus
Interventions: DRUG: SAR443122|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HeartHome: A Nurse-Driven, Home-Based Cardiac Rehabilitation Program
Status: COMPLETED
Conditions: Myocardial Infarction|Acute Coronary Syndrome|ST-segment Elevation Myocardial Infarction (STEMI)|Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)|Angina, Stable
Interventions: BEHAVIORAL: HeartHome
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MEG Versus EEG HR for the Localization of the Epileptogenic Zone as Part of the Pre-surgical Assessment of Epilepsy
Status: RECRUITING
Conditions: Drug-resistant Epilepsy|Candidates for Surgical Treatment|Epilepsy
Interventions: PROCEDURE: MEG - EEG HR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of NRL972 in Patients With Nonalcoholic Steatohepatitis (NASH) and Non-Alcoholic Fatty Liver Disease (NAFLD)
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Nonalcoholic Steatohepatitis
Interventions: DRUG: NRL972
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Smecta in the Treatment of Acute Diarrhoea in Children
Status: COMPLETED
Conditions: Diarrhoea
Interventions: DRUG: Smecta (Diosmectite), duration of treatment - 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of BioCart™II With Microfracture for Treatment of Cartilage Defects of the Femoral Condyle
Status: UNKNOWN
Conditions: Symptomatic Cartilage Defects of the Femoral Condyle
Interventions: BIOLOGICAL: BioCart™II|PROCEDURE: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oxidized Plant Sterols on Serum Concentrations of Plant Sterol Oxidation Products (POP)
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: cookies enriched with POP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dysphagia After Different Swallowing Therapies
Status: COMPLETED
Conditions: Dysphagia|Videofluoroscopy|Stroke
Interventions: OTHER: general swallowing therapy|OTHER: NMES therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Adults Unprimed and Primed With Adjuvanted or Non-adjuvanted Influenza Vaccines
Status: COMPLETED
Conditions: Prophylaxis of Avian Influenza Vaccine
Interventions: BIOLOGICAL: Fluad H5N1 Pandemic Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU
Status: COMPLETED
Conditions: Patients With Acute Renal Insufficiency
Interventions: DRUG: Citrate 4%|DRUG: unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Research Evaluation for Ambulatory Leadless Electrocardiogram Recorder Trial
Status: COMPLETED
Conditions: Atrial Fibrillation|Tachycardia, Supraventricular|Bradyarrhythmia|Ventricular Arrythmia
Interventions: DEVICE: HeartWatch|DEVICE: Event Recorder|DEVICE: Holter Monitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GROWing Up With Rare GENEtic Syndromes
Status: RECRUITING
Conditions: Prader-Willi Syndrome|PWS-like Syndrome|Silver Russel Syndrome|Congenital Hypopituitarism|Klinefelter (XXY-)Syndrome|Congenital Adrenal Hyperplasia|XXXXY Syndrome|XXYY Syndrome|XXXX Syndrome (Tetra-X Syndrome)|Disorders of Sex Development|Turner Syndrome|46, XY DSD|Tuberous Sclerosis|Neurofibromatosis|Albright Hereditaire Osteodystrofie|Cornelia de Lange Syndrome|Saethre-Chotzen Syndrome|17p- Deletiesyndrome|VCF Syndrome|POLR3A Mutatie|Ohdo Syndrome|Jacobsen Syndrome / 11 q Syndrome|Myrhe Syndrome|CHARGE Syndrome|1q25-32 Deletie|Bardet Biedl Syndrome|Rett Syndrome|22q11 Deletion Syndrome|Allan-Herndon-Dudley Syndrome|Kallmann Syndrome|Rare Bone Disorders|Noonan Syndrome|Williams-Beuren Syndrome
Interventions: DIAGNOSTIC_TEST: Retrospective file studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Assessment of Bone Augmentation in Post-Extraction Sockets
Status: COMPLETED
Conditions: Unrestorable Dentition|Post-Extraction Sockets
Interventions: PROCEDURE: AtraumaticTeeth Extraction|PROCEDURE: Atraumatic Teeth Extraction/Grafted Extraction Sockets|PROCEDURE: Atraumatic Teeth Extraction/Grafted Extraction Sockets|PROCEDURE: Atraumatic Teeth Extraction/Grafted Extraction Sockets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Tegoprazan in ERD Patients With Nighttime Heartburn and Sleep Disturbance
Status: COMPLETED
Conditions: Erosive Reflux Disease
Interventions: DRUG: Tegoprazan|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immediately Placed Implants Using Simvastatin and Autogenous Tooth Graft Combination in Periodontally Compromised Sites
Status: COMPLETED
Conditions: Autogenous Tooth Bone Graft|Immediate Implant Placement|Simvastatin
Interventions: PROCEDURE: immediate implant placement with ATBG and SMV|PROCEDURE: immediate implant placement with ATBG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
Status: COMPLETED
Conditions: Myocardial Injury|Myocardial Ischemia
Interventions: DRUG: Ivabradine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Antacids on Gleevec® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Antacids (Mg-Al-based)|DRUG: Imatimib Mesylate (Gleevec®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]FES PET/CT in Endocrine Refractory Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor Positive Breast Cancer|Breast Neoplasm|Metastatic Breast Cancer
Interventions: DRUG: [18F]FES
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-Angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Open-Angle Glaucoma|Ocular Hypertension
Interventions: DRUG: Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension|DRUG: Brinzolamide 1% ophthalmic suspension|DRUG: Timolol 0.5% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Color Stability and Wear Resistance of Direct Flowable and Preheated Composite Using the Injectable Technique
Status: RECRUITING
Conditions: Resin Composite Restorations|Esthetic Restorations
Interventions: OTHER: Experimental: Group1: Estelite Sigma Quick|OTHER: Experimental: Group 2: Estelite Flow Quick
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tasimelteon for the Treatment of Non-24-hour Sleep-Wake Disorder (N24HSWD) in Blind Individuals With no Light Perception
Status: COMPLETED
Conditions: Non-24-Hour Sleep-Wake Disorder
Interventions: DRUG: tasimelteon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Monitoring to Detect Ventricular Arrhythmias in Presymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Patients
Status: TERMINATED
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis
Status: TERMINATED
Conditions: Candidiasis
Interventions: DRUG: micafungin|DRUG: amphotericin B deoxycholate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Mesotherapy Added to Intra-articular Platelet-rich Plasma (PRP) in Patients With Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: DRUG: Lidocaine 2% Injectable Solution|BIOLOGICAL: Platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VA106483 and Alpha Blocker Interaction Study in Elderly Males
Status: COMPLETED
Conditions: Nocturia
Interventions: DRUG: VA106483|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Response to Systemic and Mucosal Antigenic Challenge in the Presence of Vedolizumab
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: DRUG: Vedolizumab|DRUG: Placebo|BIOLOGICAL: Hepatitis B vaccine|BIOLOGICAL: Oral cholera vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: GSD VI and GSD IX Natural History
Status: RECRUITING
Conditions: Glycogen Storage Disease VI|GLYCOGEN STORAGE DISEASE IXa1|GLYCOGEN STORAGE DISEASE IXa2|Glycogen Storage Disease IXB|Glycogen Storage Disease IXC|GSD 9 (All Subtypes)|GSD 6
Interventions: OTHER: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomised Multi-centre Study to Compare the Short-term Outcomes of Minimally Invasive and Conventional Surgery in Primary Total Hip Replacement
Status: TERMINATED
Conditions: Osteoarthritis(Primary)
Interventions: PROCEDURE: DePuy MI System|PROCEDURE: Conventional surgical technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sex Differences in Sympathetic Vascular Reactivity at High Altitude
Status: COMPLETED
Conditions: Vasodilation|Vasoconstriction
Interventions: DRUG: Sodium Nitroprusside|DRUG: Phenylephrine Hydrochloride|DRUG: Phenylephrine Hydrochloride|DRUG: Norepinephrine|OTHER: Isometric Handgrip and Post-Exercise Circulatory Occlusion|OTHER: Rhythmic Handgrip|OTHER: Cold Pressor Test|DRUG: Propranolol Hydrochloride|DRUG: Phentolamine Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With Cancer
Status: COMPLETED
Conditions: Neoplasm Metastasis
Interventions: DRUG: Olaratumab|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Irinotecan|DRUG: Ifosfamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Online Cognitive Control Training on Rumination and Depressive Symptoms
Status: COMPLETED
Conditions: Depression|Rumination - Thoughts
Interventions: BEHAVIORAL: Adaptive emotional cognitive control training|BEHAVIORAL: Adaptive non-emotional feature match task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury
Status: COMPLETED
Conditions: Anemia|Traumatic Brain Injury
Interventions: DRUG: recombinant human erythropoietin, rhEpo|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antihypertensive Pharmacological Therapy With Mineralocorticoid Receptor Antagonists in Obese Hypertensive Patients
Status: UNKNOWN
Conditions: Hypertension|Obesity
Interventions: DRUG: Eplerenone (-based therapy) arm|DRUG: Valsartan (-based therapy) arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in Israel
Status: COMPLETED
Conditions: Shigellosis
Interventions: BIOLOGICAL: Shigella conjugate vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Genitourinary Cancer|Adrenocortical Carcinoma|Non-urothelial Bladder|Non-urothelial Upper Tract|Penile Cancer|Non-adenocarcinoma Prostate Cancer|Refractory Germ-cell|High Grade Neuroendocrine Carcinoma/Small Cell Carcinoma
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of U-relax on Vaginal Health Promotion and HPV DNA Test Change From Positive to Negative
Status: COMPLETED
Conditions: Human Papillomavirus|Vaginal Infection
Interventions: DIETARY_SUPPLEMENT: U-relax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study in Patients With Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: SHR0302
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ceramic Soft Tissue Trimming Bur Versus Conventional Scalpel Technique in Ginigival Depigmentation Procedure
Status: COMPLETED
Conditions: Hyperpigmentation
Interventions: PROCEDURE: depigmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT