pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nonpharmacological Methods for Children in Procedural Pain
Status: COMPLETED
Conditions: Procedural Pain|Procedural Anxiety
Interventions: OTHER: Distraction cards|OTHER: Virtual reality|OTHER: Buzzy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Closed Loop Glucose Control in Patients With Type 1 and Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DEVICE: Fusion closed loop glucose control system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liberal Versus Restrictive Fluid Protocols in Adults
Status: COMPLETED
Conditions: Intraoperative Complications
Interventions: DRUG: Ringer lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Analgesics in Cesarean Section Elective
Status: COMPLETED
Conditions: Anesthesia; Functional
Interventions: DRUG: Hyperbaric bupivacaine+Sufentanil|DRUG: Hyperbaric bupivacaine+Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mood on Cerebral Perfusion
Status: COMPLETED
Conditions: Cerebral Perfusion
Interventions: BEHAVIORAL: Mood induction (using own memories)|DEVICE: Arterial spin labeling MRI|DEVICE: Physiological monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Efficacy and Safety of Combined Administration of TAK-536CCB and Hydrochlorothiazide in Patients With Grade I or II Essential Hypertension.
Status: COMPLETED
Conditions: Grade I or II Essential Hypertension
Interventions: DRUG: TAK-536CCB|DRUG: TAK-536CCB + Hydrochlorothiazide|DRUG: Hydrochlorothiazide|DRUG: Hydrochlorothiazide|DRUG: TAK-536CCB + Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Lachrymal Substitutes on Tear Film Thickness in Patients With Moderate Dry Eye Syndrome
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DEVICE: Thealoz Duo®|DEVICE: Hyabak®|DEVICE: Hydrabak®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Efficacy of Multiple Doses of VB-201 on Biomarkers
Status: COMPLETED
Conditions: Biomarker
Interventions: DRUG: VB-201 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: UARK 2012-02 Trial For High-Risk Myeloma Evaluating Accelerating and Sustaining Complete Remission
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DEVICE: myPRS|DRUG: Induction 1 - MEL-10+CFZ-TD-PACE|DRUG: First Transplant - MEL-80+CFZ-TD-PACE + PBSC (biologic)|DRUG: Inter-Therapy - MEL-20+CFZ-TD-PACE (75%)|DRUG: Second Transplant - MEL-80+CFZ-TD-PACE + PBSC (biologic)|DRUG: Consolidation - CFZ-TD-PACE|DRUG: Maintenance - CFZ-R(T)-D
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Biological Therapy in Treating Patients With Stage II or Stage III Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Clonidine for Postoperative Pain Management in Patients Undergoing Surgical Treatment for Endometriosis
Status: COMPLETED
Conditions: Endometriosis|Postoperative Pain|Pain, Acute|Pain, Acute Postoperative
Interventions: DRUG: Clonidine|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome Following Use of NaOCl and Chlorhexidine as Wound Lavage Agents
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: PROCEDURE: Partial pulpotomy|PROCEDURE: Partial pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Escalation Study of Onc201 Administered Every One or Three Weeks in Advanced Solid Tumors and Multiple Myeloma
Status: COMPLETED
Conditions: Advanced Solid Tumors|Multiple Myeloma
Interventions: DRUG: ONC-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Combination of Necitumumab (LY3012211) and Pembrolizumab (MK3475) in Participants With NSCLC
Status: COMPLETED
Conditions: Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Necitumumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Model Primary, Secondary, and Tertiary Dengue Using a Monovalent Vaccine
Status: RECRUITING
Conditions: Response To Dengue Exposure
Interventions: DRUG: rDENdelta30/31-7164
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mobile Application to Assist Adherence to Oral Anticancer Agents and Symptom Management
Status: COMPLETED
Conditions: Cancer|Adherence to Medication Regime|Symptom Management
Interventions: OTHER: Mobile Application Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1 Multicenter, Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Response of PE0139 Injection in Adult Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: PE0139 Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Explorative Clinical Investigation to Investigate the Ability of PreciseInhale to Direct Regional Lung Targeting and Reduce the Degree of Throat Deposition and Subsequent Gastrointestinal Absorption in Healthy Volunteers After Inhalation of Test Drug Substances Via the PreciseInhale System
Status: COMPLETED
Conditions: Nebulizers and Vaporizers
Interventions: DEVICE: PreciseInhale|OTHER: Seretide Evohaler forte
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparison of Diabetes Mellitus and Non-diabetes Mellitus Patients for DES Surface COVERage by OCT
Status: UNKNOWN
Conditions: Coronary Heart Disease|Diabetes Mellitus
Interventions: DEVICE: Polymer-based sirolimus-eluting stent(Cypher stent ) and Polymer-free paclitaxel-eluting stent (YinYi stent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine and High-Dose Melphalan Followed by Donor Stem Cell Transplant in Patients With Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: clofarabine|DRUG: melphalan|GENETIC: gene expression analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: flow cytometry|OTHER: laboratory biomarker analysis|PROCEDURE: allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of 'Ursa Complex Soft Cap. (UDCA-004)' in Patients With Physical Fatigue.
Status: COMPLETED
Conditions: Fatigue
Interventions: DRUG: Ursodeoxycholic acid, taurine, ginsenoside, thiamine, inositol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Nitric Oxide/INP Pulse Delivery|DRUG: Nitric Oxide/INO Pulse Delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Role of Left Atrial Fibrosis in Mitral Valve Repair Surgery (ALIVE Trial)
Status: COMPLETED
Conditions: Mitral Valve Disease|Mitral Regurgitation|Surgery|Cardiac Valve Disease|Mitral Valve Surgery|Mitral Valve Repair
Interventions: DIAGNOSTIC_TEST: 3 DImensional Late Enhanced Gadolinium cardiac MRI scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: "Performance of HPV DNA Test in Presence of Co-infection With Common RTIs"
Status: UNKNOWN
Conditions: Cervical Inflammation and Human Papilloma Virus Performance
Interventions: DRUG: Tab cefixime,Tab Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Open Inguinal Hernia Repair With Mesh,the Use of Absorbable Versus Non Absorbable Fixation Sutures
Status: WITHDRAWN
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Open Inguinal Hernia Repair With Mesh,the Use of Absorbable Versus Non Absorbable Fixation Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clesrovimab (MK-1654) in Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease (MK-1654-007)
Status: ACTIVE_NOT_RECRUITING
Conditions: RSV Infection
Interventions: BIOLOGICAL: Clesrovimab|BIOLOGICAL: Palivizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Efficacy of Prograf/FK778 and Prograf/MMF in de Novo Kidney Transplant Recipients
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: DRUG: FK778
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Nonsteroidal Anti-inflammatory Drugs in People With Painful Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Naproxen 500 Mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Activity of ISIS 113715 in People With Type 2 Diabetes Mellitus Who Have Not Received Prior Treatment
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: ISIS 113715
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: SHR-A1811 Alone or in Combination With Adebrelimab as Neoadjuvant Treatment in ER Positive/HER2 Low Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: ER Positive/HER2 Low Breast Cancer
Interventions: DRUG: SHR-A1811 Injection + Adebrelimab Injection|DRUG: SHR-A1811 Injection + Adebrelimab Injection|DRUG: SHR-A1811 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Dosing and Frequency of BCG Administration to Alter T-Lymphocyte Profiles in Type I Diabetics
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: BCG|BIOLOGICAL: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Block for Postoperative Analgesia in Arthroscopic Shoulder Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Analgesia
Interventions: PROCEDURE: High Thoracic Erector Spinae Plane Block|PROCEDURE: Shoulder Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Manufacturing Transfer Study Comparing the Bioequivalence of a Single Oral Dose of Claritin-D 12-Hour Extended Release Tablet From 2 Different Manufacturers Under Fasted Conditions in Healthy Adult Subjects
Status: COMPLETED
Conditions: Clinical Pharmacology
Interventions: DRUG: Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-SAG)|DRUG: Loratadine + Pseudoephedrine sulfate (Claritin-D, BAY818725) (Manufacturer-Heist)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Motivational Interview Intervention to Help Patients Formulate Their Goals for Medical Care in the Emergency Department
Status: COMPLETED
Conditions: Emergency Service, Hospital|Motivational Interviewing|Advance Care Planning
Interventions: BEHAVIORAL: Brief motivational interview intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Study of 3 Portable Oxygen Concentrators During a 6-minute Walk Test in Patients With Chronic Lung Disease
Status: COMPLETED
Conditions: Chronic Obstructive Lung Disease|Pulmonary Fibrosis
Interventions: DEVICE: Eclipse 3 portable oxygen concentrator|DEVICE: EverGo portable oxygen concentrator|DEVICE: iGo portable oxygen concentrator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
Status: COMPLETED
Conditions: Sinusitis
Interventions: DRUG: Saline|DRUG: Gentamycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Episcleral Dexamethasone for Treatment of Macular Edema
Status: ACTIVE_NOT_RECRUITING
Conditions: Refractory Diabetic Macular Edema
Interventions: DRUG: Episcleral Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Combination of Doxorubicin, Cisplatin and Methotrexate in Patients Aged 24-40 Years With Primary Bone Tumors
Status: RECRUITING
Conditions: Osteosarcoma|Neoplasms, Connective Tissue|Neoplasms, Connective and Soft Tissue|Sarcoma|Sarcoma of Bone
Interventions: DRUG: Doxorubicin, Cisplatin, Methotrexate|DRUG: Doxorubicin, Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient, Physician, and Nurse Factors Associated With Entry Onto Clinical Trials and Finishing Treatment in Patients With Primary or Recurrent Uterine, Endometrial, or Cervical Cancer
Status: COMPLETED
Conditions: Recurrent Cervical Carcinoma|Recurrent Uterine Corpus Carcinoma|Recurrent Uterine Corpus Sarcoma|Stage I Uterine Corpus Cancer|Stage I Uterine Sarcoma|Stage IA Cervical Cancer|Stage IB Cervical Cancer|Stage II Uterine Corpus Cancer|Stage II Uterine Sarcoma|Stage IIA Cervical Cancer|Stage IIB Cervical Cancer|Stage III Cervical Cancer|Stage III Uterine Corpus Cancer|Stage III Uterine Sarcoma|Stage IV Uterine Corpus Cancer|Stage IV Uterine Sarcoma|Stage IVA Cervical Cancer|Stage IVB Cervical Cancer
Interventions: OTHER: Medical Chart Review|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pre-Surgical PK Study of IM and Intraductally Delivered Fulvestrant
Status: TERMINATED
Conditions: Female Breast Carcinoma|Female Ductal Carcinoma In Situ
Interventions: DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Immunization Quality Improvement Dissemination Study
Status: COMPLETED
Conditions: Immunization|DTaP Vaccine|Hepatitis B Vaccine|MMR Vaccine|HIB-vaccine|Poliovirus Vaccine, Inactivated|Chickenpox Vaccine|Pneumococcal Polysaccharide Vaccine
Interventions: BEHAVIORAL: QI support to improve DTP/Hep B/MMR/Var/PCV/Hib/IPV coverage|BEHAVIORAL: Incentives to improve DTP/HepB/MMR/Var/PCV/Hib/IPV coverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study to Determine the Efficacy of Real-time CGM in Preventing Hypoglycemia Among Insulin-treated Patients With DM2 on Hemodialysis, Compared to Standard of Care (POC BG)
Status: COMPLETED
Conditions: End-Stage Renal Disease|Type 2 Diabetes
Interventions: DEVICE: Dexcom real-time G6 Continuous Glucose Monitoring System (CGM)|DIAGNOSTIC_TEST: POC BG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Chronic Polyarthritis|Juvenile Idiopathic Arthritis|Juvenile Rheumatoid Arthritis
Interventions: DRUG: methotrexate|DRUG: methotrexate - etanercept - prednisolone arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Status: NOT_YET_RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DEVICE: Sham-stimulation|DEVICE: Active-stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 5-Azacitidine in Low-risk Myelodysplastic Syndromes (MDSs)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients
Status: TERMINATED
Conditions: Cystic Fibrosis|Rhinosinusitis|Lung Diseases
Interventions: DRUG: Tobramycin nebulized nasally|DRUG: Physiologic serum nebulized nasally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of Daily OM-85 in Young Children With Recurrent Wheezing
Status: RECRUITING
Conditions: Recurrent Wheezing|Wheezing Lower Respiratory Illness
Interventions: DRUG: OM-85|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Computerized Intervention of Parental Involvement in Diabetes Care of Their Child
Status: COMPLETED
Conditions: Diabetes
Interventions: BEHAVIORAL: Parent Computer-Delivered Motivational Intervention|BEHAVIORAL: Parent & Child Computer-Delivered Motivational Intervention|BEHAVIORAL: Computer-Delivered Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance
Status: RECRUITING
Conditions: Motion Sickness, Space|Motion Simulation|Parabolic Flight
Interventions: DRUG: DPI-386 Nasal Gel|DRUG: Other (e.g., promethazine, meclizine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postpartum Hemorrhage Prevention in Patients With Preeclampsia (PHP3 Study)
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients With Chronic Lymphocytic Leukemia ("PRO-SID" Study)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Hypogammaglobulinemia
Interventions: BIOLOGICAL: Panzyga|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Efficacy of Pembrolizumab Plus Radiotherapy in Metastatic Triple Negative Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer|Metastatic Triple Negative
Interventions: DRUG: Pembrolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine in Combination With Mitoxantrone, Etoposide Phosphate, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Recurrent Adult Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Cytarabine|DRUG: Etoposide Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mitoxantrone Hydrochloride|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CS0159 Combined With Semaglutide in MASH Patients With Obesity and T2DM
Status: NOT_YET_RECRUITING
Conditions: Metabolic Dysfunction-Associated Steatohepatitis (MASH)|Obesity|Diabetes Mellitus, Type 2
Interventions: DRUG: CS0159|DRUG: CS0159 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Unlocking Movement Potential: Enhancing Parkinson's Disease Treatment With Robotic EksoSkeleton
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Eksobionics Eksoskeleton NR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clusterin, Ptx3 and Pediatric Febrile Neutropenia (CluPPFeN)
Status: RECRUITING
Conditions: Cancer Childhood|Febrile Neutropenia
Interventions: OTHER: Collection of blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock|Microcirculation
Interventions: DEVICE: Sidestream Dark Field (SDF)|DEVICE: Near Infrared Spectroscopy (NIRS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: At Work and Coping - Effect Study of Workcoping for Patients With Anxiety and Depression
Status: COMPLETED
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Workcoping and IPS|BEHAVIORAL: Ordinary care by GP or NAV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Tract Microbiome and Probiotics in Children With Cleft Palate
Status: RECRUITING
Conditions: Otitis Media in Children|Cleft Palate Children
Interventions: DIETARY_SUPPLEMENT: Probactiol Baby
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Randomized, Double-Blind, Placebo Controlled, Crossover Trial to Evaluate Safety and Efficacy of AGY in Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: AGY|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability, Pharmacokinetics of ALZ002 DS in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALZ002 DS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast-enhanced Bowel Ultrasound in Making a Diagnosis and Follow-up of Patients With Inflammatory Bowel Disease
Status: UNKNOWN
Conditions: Inflammatory Bowel Disease
Interventions: DIAGNOSTIC_TEST: Contrast-enhanced Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Palliative Care for Non-Malignant Diseases (COMPASS Trial)
Status: TERMINATED
Conditions: Liver Diseases|Liver Cirrhosis|NASH (Non-Alcoholic Steatohepatitis)
Interventions: OTHER: Comprehensive Palliative Care services|OTHER: Usual hepatic care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adjuvant Use of Neostigmine in Sepsis and Septic Shock.
Status: COMPLETED
Conditions: Sepsis, Septic Shock
Interventions: DRUG: Neostigmine|DRUG: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Creatine Monohydrate as Adjuvant Therapy for Bipolar Depression
Status: COMPLETED
Conditions: Bipolar I Disorder|Current Episode Depressed
Interventions: DIETARY_SUPPLEMENT: creatine monohydrate|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ONC201 in Pediatric H3 K27M Gliomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Intrinsic Pontine Glioma|Glioma, Malignant
Interventions: DRUG: ONC201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Ginseol Kg1 on Blood Pressure Lowering
Status: UNKNOWN
Conditions: Prehypertension|Hypertension, Stage I
Interventions: DRUG: Ginseol Kg1 (low dose)|DRUG: Ginseol Kg1(high dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Peer-Educator-coordinated vs Nurse-coordinated ART Refill for Adolescents and Young Adults Living With HIV in Lesotho
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: OTHER: PEBRA model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Effect of Sodium Zirconium Cyclosilicate on Albuminuria in Patients With Type 2 Diabetes and Hyperkalemia
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus With Kidney Complications
Interventions: DRUG: LOKELMA 5 GM Powder for Oral Suspension|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of 3D Printed Prostheses on Neural Activation Patterns
Status: RECRUITING
Conditions: Amniotic Band Syndrome|Upper Extremity Deformities, Congenital
Interventions: DEVICE: 3D Printed Upper-limb Prosthesis|BEHAVIORAL: Home Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sublingual Misoprostol & Isoflurane During Caesarean Section
Status: COMPLETED
Conditions: Pregnancy|Cesarean Delivery
Interventions: DRUG: Placebo|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of a Tai Chi Resilience Training Program on Objective and Subjective Measures of Post Traumatic Stress Disorder Severity
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Tai Chi|Aerobic Exercise
Interventions: BEHAVIORAL: Tai Chi Moving Mindfulness Meditation and Resilience Training|BEHAVIORAL: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Airway Microbiome Changes After Artificial Airway Exchange in Critically-ill Pediatric Patients.
Status: RECRUITING
Conditions: Tracheostomy|Endotracheal Tube|Ventilator Associated Pneumonia|Tracheitis|Microbial Colonization|Pediatric Infectious Disease|Pediatrics
Interventions: DIAGNOSTIC_TEST: Suctioning of artificial airway
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post Approval Study of the AcrySof® IQ ReSTOR® Toric IOLs
Status: COMPLETED
Conditions: Aphakia|Presbyopia|Astigmatism
Interventions: DEVICE: ACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL|DEVICE: ACRYSOF IQ RESTOR +2.5 D Multifocal Toric IOL|DEVICE: ACRYSOF IQ RESTOR +2.5 D Multifocal IOL|PROCEDURE: Cataract Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Vitamin C|DRUG: L-Carnitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Volumetric Assessment of Volume Stable Collagen Matrix in Soft Tissue Ridge Augmentation
Status: COMPLETED
Conditions: Buccal Defect at Implant Sites
Interventions: BIOLOGICAL: volume stable collagen matrix placement|PROCEDURE: connective tissue grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Genius Study Study to Compare Efficacy and Safety of Gefitinib/ Pemetrexed With Pemetrexed Alone as Maintenance Therapy in Patients With Stage IV EGFR Mutation Negative or T790M Single Mutation Who Respond to Pemetrexed/ Platinum as First-line Therapy
Status: UNKNOWN
Conditions: NSCLC
Interventions: DRUG: Pemetrexed 500mg/m2 iv|DRUG: Pemetrexed 500mg/m2 iv and Gefitinib 250 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Endoxifen in Women
Status: COMPLETED
Conditions: Mammographic Breast Density
Interventions: DRUG: Topical endoxifen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pasireotide Long Acting Release vs. Octreotide Long Acting Release in Patients With Metastatic Carcinoid Disease
Status: COMPLETED
Conditions: Symptomatic Refractory Resistant Carcinoid Disease
Interventions: DRUG: Pasireotide|DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Toxicity Reduction Via Urea Cycle Support
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Citrulline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nasal Mask Kit in Gastrointestinal Endoscopy
Status: UNKNOWN
Conditions: Hypoxia|Gastric Cancer|Gastric Polyp|Colon Polyp|Colon Cancer|Esophageal Cancer
Interventions: DEVICE: nasal mask oxygen kit|DEVICE: regular nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of AL3818 in Combination With Nivolumab in Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor, Adult|Soft Tissue Sarcoma|Non Small Cell Lung Cancer|Small Cell Lung Cancer
Interventions: DRUG: AL3818|DRUG: Nivolumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Valacyclovir for Mild Cognitive Impairment
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment|Herpes Simplex 1|Herpes Simplex 2
Interventions: DRUG: Valacyclovir hydrochloride 500mg caplet|DRUG: Placebo sugar pill caplet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Reamed Locked Plating - Metaphyseal Fractures of the Distal Femur and Tibia
Status: TERMINATED
Conditions: Femoral Fractures|Tibial Fractures
Interventions: PROCEDURE: RIA bone graft|PROCEDURE: Surgery without bone graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Letermovir for Secondary Prophylaxis in Solid Organ Transplant Recipients
Status: RECRUITING
Conditions: Cytomegalovirus Infections|Infection in Solid Organ Transplant Recipients|Neutropenia|Antiviral Toxicity
Interventions: DRUG: Letermovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Biomarkers in Predicting Response to Treatment in Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer Treated With Carboplatin, Paclitaxel, and Radiation Therapy
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: GENETIC: DNA Microarray analysis|GENETIC: MALDI-TOF mass spectrometry|GENETIC: DNA microarray and MALDI-TOF mass spectrometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Firefighters Accessing Care for Trauma: A Clinical Case Series of Distance NET for PTSD/I Symptoms
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder|Post Traumatic Stress Injury
Interventions: BEHAVIORAL: Distance-delivered NET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durolane Versus Phosphate Buffered Saline (PBS) in Knee Osteoarthritis
Status: TERMINATED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Durolane|DEVICE: PBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4SCAR-T Therapy Post CD19-targeted Immunotherapy
Status: UNKNOWN
Conditions: CD19 Negative B-cell Malignancies
Interventions: BIOLOGICAL: Infusion of 4SCAR-T specific to CD22/CD123/CD38/ CD10/CD20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cerebellar tDCS Stimulation in Children and Adult Women With Anorexia Nervosa Disorder
Status: RECRUITING
Conditions: Anorexia Nervosa
Interventions: DEVICE: anodal trans cranial direct current stimulation (tDCS)|DEVICE: cathodal trans cranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lateral Wedge Insoles, Knee Taping on the Management of Knee Osteoarthritis
Status: COMPLETED
Conditions: Medial Compartment Knee Osteoarthritis
Interventions: OTHER: Mulligan Knee Taping with Home Exercises|OTHER: Lateral wedge insoles with Home Exercises|OTHER: Traditional Physiotherapy with Home Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: fMRI Connectivity in Fracture Hip Patients
Status: COMPLETED
Conditions: Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: BEHAVIORAL: fMRI|BEHAVIORAL: Montreal Cognitive Assessment (MoCA)|BEHAVIORAL: Digital Clock Drawing Test Command and Copy|BEHAVIORAL: Wide Range Achievement Test reading subtest|BEHAVIORAL: Hopkins Verbal Learning Test (HVLT)|BEHAVIORAL: General Depression Scale (GDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stem Cell Transplant for Hematological Malignancy
Status: TERMINATED
Conditions: Leukemia, Myeloid, Chronic|AML|Leukemia, Lymphocytic, Acute|MDS|Leukemia, Lymphocytic, Chronic|JMML|Hodgkin's Disease|Non-hodgkin's Lymphoma|Multiple Myeloma
Interventions: BIOLOGICAL: Stem Cell Transplant|DRUG: Cyclophosphamide|RADIATION: Total Body Irradiation|DRUG: Busulfan|DRUG: Equine ATG (ATGAM)|BIOLOGICAL: CD4+/CD25+ cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of a New Reduced Volume Bowel Preparation
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: macrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Costal Osteochondral Transplantation for Talar Osteochondral Lesions
Status: RECRUITING
Conditions: Articular Cartilage Defect
Interventions: PROCEDURE: Autologous costal osteochondral transplantation|PROCEDURE: Autologous iliac osteoperiosteal transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Importance of Insulin Action in the Brain for the Immune System During Physical Activity
Status: RECRUITING
Conditions: Insulin Sensitivity
Interventions: OTHER: Spiroergometer test with intranasal insulin spray|OTHER: Spiroergometer test with intranasal placebo spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Status: COMPLETED
Conditions: Gynecologic Neoplasms|Venous Thromboembolism|Low Molecular Weight Heparin|Argatroban
Interventions: DRUG: s-LMWH|DRUG: LMWH|DRUG: Argatroban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Hematopoietic and Lymphoid System Neoplasm|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Waldenstrom Macroglobulinemia
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of Bilingual Prescription Medication Labels Among Elderly Singaporeans
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: DEVICE: Bilingual prescription medication labels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Trial to Evaluate the Safety of RQ-01 in SARS-CoV-2 Positive Subjects
Status: COMPLETED
Conditions: COVID-19|Infectious Disease|Symptomatic COVID-19 Infection Laboratory-Confirmed|SARS CoV 2 Infection
Interventions: COMBINATION_PRODUCT: RQ-001|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automated Oxygen Titration During Walking in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Respiratory Failure
Interventions: OTHER: Fixed-dose compared to variable oxygen flow supplementation during walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Ranibizumab for the Prevention of Radiation Maculopathy Following Plaque Radiotherapy
Status: UNKNOWN
Conditions: Uveal Melanoma|Radiation Retinopathy|Radiation Maculopathy
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: MIRRORS-RCT Pilot: Role of Robotic Interval Cytoreductive Surgery for Advanced Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Ovarian Neoplasm|Ovarian Neoplasm Epithelial|Fallopian Tube Cancer|Fallopian Tube Neoplasms|Peritoneal Cancer
Interventions: PROCEDURE: MIRRORS Protocol|PROCEDURE: Standard Open Cytoreductive Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of Clinical Safety and Performance of the SP-GRIPFLOW, Selective Cerebral Perfusion Catheter When Used for Cerebral Perfusion During Aortic Arch Repair
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Aneurysm|Aortic Dissection|Aortic Arch Aneurysm|Aortic Arch; Aneurysm, Dissecting
Interventions: DEVICE: Selective Cerebral Perfusion Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Commitment Therapy-based Eczema Management Programme
Status: COMPLETED
Conditions: Eczema
Interventions: BEHAVIORAL: Family Acceptance and Commitment Therapy-based Eczema Management Programme|BEHAVIORAL: Wait-list Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Immunogenicity and Safety of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in High-risk Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Virus
Interventions: BIOLOGICAL: mRNA-1345
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ADI-PEG 20 Plus Radiotherapy and Temozolomide in Subjects With Glioblastoma Multiforme
Status: RECRUITING
Conditions: Glioblastoma Multiforme (GBM)
Interventions: DRUG: ADI-PEG20|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pantoprazole in Patients Older Than 12 Years Who Have Symptoms of Non-Erosive Reflux Disease (NERD) or Erosive Gastroesophageal Reflux Disease (eGERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Pantoprazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Donation From Warfarin Users for the Development of POC INR Monitor
Status: UNKNOWN
Conditions: Atrial Fibrillation|Pulmonary Embolism|Deep Vein Thrombosis
Interventions: PROCEDURE: Venepuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Telitacicept on Antibody Titers in Primary APS Patients
Status: RECRUITING
Conditions: Antiphospholipid Syndrome (APS)
Interventions: DRUG: Telitacicept|DRUG: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthesia Induction With the Target-controlled Infusion of Propofol in High-risk Patients
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Hemodynamic Instability
Interventions: DRUG: Manual anesthesia induction|DRUG: Anesthesia induction with Target controlled infusions (TCI)|DEVICE: Hemodynamic monitoring with pressure recording analytical method (PRAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING