pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: L-Carnosine for Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: L-carnosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Depth and Duration of Anesthesia
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Synera™ Topical Patch (70 mg lidocaine/70 mg tetracaine)|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules
Status: COMPLETED
Conditions: Skin Aging|Photoaging of Skin
Interventions: DRUG: 2-Minute Reveal Masque|DRUG: 24/7 Barrier Repair Cream|DRUG: 8-in-1 BioSerum|DRUG: Null Formula 2-Minute Reveal Masque|DRUG: Null Formula 24/7 Barrier Repair Cream|DRUG: Null Formula 8-in-1 BioSerum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LEO 90100 Compared to Vehicle in Subjects With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: LEO 90100|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RRISC Study: Reduction of Restenosis In Saphenous Vein Grafts With Cypher Sirolimus-Eluting Stent.
Status: COMPLETED
Conditions: Stable Angina|Unstable Angina|Coronary Artery Disease|Saphenous Vein Graft Disease
Interventions: DEVICE: sirolimus-eluting stent|DEVICE: bare metal stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: IVUS Versus FFR for Non-infarct Related Artery Lesions in Patients With Multivessel Disease and Acute STEMI
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: IVUS-guided PCI group|DIAGNOSTIC_TEST: FFR-guided PCI group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrolyzed Egg and Tolerance Induction
Status: COMPLETED
Conditions: Allergy
Interventions: DIETARY_SUPPLEMENT: HA egg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Clopidogrel Exposure to Decrease Hemorrhage and Transfusion
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Tranexamic Acid|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Paclitaxel With or Without Ramucirumab (IMC-1211B) in Metastatic Gastric Adenocarcinoma
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: BIOLOGICAL: Ramucirumab (IMC-1211B) DP|DRUG: Placebo|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR)
Status: COMPLETED
Conditions: Shigellosis|Bacillary Dysentery
Interventions: BIOLOGICAL: Shigella flexneri 2a InvaplexAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of MHAA4549A in Combination With Oseltamivir Versus Oseltamivir in Participants With Severe Influenza A Infection
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: MHAA4549A|DRUG: Oseltamivir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Validity of the Quick Renal MRI in Pediatric Kidney Disease
Status: RECRUITING
Conditions: Pyelonephritis|Pyelonephritis Acute|Renal Sclerosis
Interventions: DIAGNOSTIC_TEST: Quick MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Yuxintine With Placebo in Treatment of MDD
Status: UNKNOWN
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: Yuxintine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Superficial Peroneal Nerve Neuromodulation for Non-Obstructive Urinary Retention
Status: RECRUITING
Conditions: Urinary Retention|Urinary Bladder, Underactive
Interventions: DEVICE: superficial peroneal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low Protein Renal Formula as Meal Replacement in Predialysis CKD Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: Low protein diet with Fresubin® renal|OTHER: Low protein diet with normal food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Long-term Safety and Efficacy Study of Fentanyl Sublingual Spray for the Treatment of Breakthrough Cancer Pain
Status: COMPLETED
Conditions: Cancer|Pain
Interventions: DRUG: Fentanyl sublingual spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Oral Doses of BI 44847 in Female and Male Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 44847|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cesarean Scar Evaluation Using Saline Infusion Sonography in Women With Previous Pregnancy in Scar
Status: NOT_YET_RECRUITING
Conditions: Uterus; Scar
Interventions: DRUG: Saline infusion sonography for evaluation of cesarean scar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Livial Intervention Following Breast Cancer; Efficacy, Recurrence and Tolerability Endpoints (LIBERATE)(COMPLETED)(P05885)
Status: COMPLETED
Conditions: Breast Cancer|Climacteric Symptoms
Interventions: DRUG: tibolone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Kinesio Taping With Cervical Spondylosis
Status: COMPLETED
Conditions: Cervical Spondylosis
Interventions: OTHER: conventional physical therapy|OTHER: Active Kinesiotaping|OTHER: Sham Kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Radiofrequency for Chronic Mastalgia of Fibrocystic Disease of the Breast
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: PROCEDURE: PRF|PROCEDURE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Treatment on Connective Tissue in Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Connective Tissue Defect (Diagnosis)
Interventions: OTHER: IASTM application|OTHER: Kinesio Tape® Tex Gold)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Neuropathic Pain in Pregnancy
Status: COMPLETED
Conditions: Pain|Pregnancy
Interventions: BEHAVIORAL: painDETECT Questionnaire|BEHAVIORAL: Pain Catastrophizing Scale|BEHAVIORAL: Pain Intensity Scale, Pain Interference Scale, Pain Behavior Scale|BEHAVIORAL: Beck Depression Inventory|BEHAVIORAL: Visual Analogue Scale|BEHAVIORAL: Patient's Global Impression of Change Scale & Clinical Global Impression-Global Improvement Scale|DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: AZD1775
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inherited Diseases, Caregiving, and Social Networks
Status: COMPLETED
Conditions: Undiagnosed Disease|Healthy Volunteer (Adult With Typically Developing Child)|Inherited Neurodegenerative Disorders|Inherited Metabolic Disorders (Inborn Errors of Metabolism)|Alzheimer's Disease and Related Dementias
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Of PF-05175157 In Healthy Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: PF-05175157 or Placebo|DRUG: PF-05175157 or Placebo|DRUG: PF-05175157 or Placebo|DRUG: PF-05175157 or Placebo|DRUG: PF-05175157 or Placebo|DRUG: PF-05175157 or Placebo|DRUG: PF-05175157 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Terumo Aortic Global Endovascular Registry
Status: RECRUITING
Conditions: Abdominal Aortic Aneurysm|Thoracic Aortic Aneurysm|Surgery
Interventions: DEVICE: Thoracic|DEVICE: Abdominal|DEVICE: Custom Device|DEVICE: Illiac Artery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Foley Catheter With and Without Extra-Amniotic Saline Infusion for Labor Induction
Status: COMPLETED
Conditions: Labor Induction|Cervical Ripening
Interventions: DEVICE: Transcervical Foley Catheter|DEVICE: Transcervical Foley Catheter with an EASI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLOSE-guided Pulmonary Vein Isolation Using High Power and Stable RF Applications
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: High power CLOSE-guided PVI ablation|PROCEDURE: Standard CLOSE-guided PVI ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
Status: RECRUITING
Conditions: Knee Arthroplasty, Total
Interventions: DRUG: Losartan|DRUG: Placebo - Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: LOSS- Louisiana Obese Subjects Study
Status: TERMINATED
Conditions: Obesity
Interventions: BEHAVIORAL: group sessions|DRUG: sibutramine, orlistat, diethylpropion|BEHAVIORAL: Low Calorie Diet, Health One|OTHER: Intensive Medical Combination Therapy for Obesity|OTHER: Control Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Prothrombin Gene and Methylenetetrahydrofolate Reductase(MTHFR) Gene Polymorphisms as Risk Factors for Recurrent Miscarriage
Status: UNKNOWN
Conditions: Recurrent Miscarriage
Interventions: DIAGNOSTIC_TEST: polymerase chain reaction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Therapeutic Control of Aspirin-Exacerbated Respiratory Disease With Ifetroban
Status: COMPLETED
Conditions: Nasal Polyps|Asthma, Aspirin-Induced|Aspirin-exacerbated Respiratory Disease|Aspirin-Sensitive Asthma With Nasal Polyps
Interventions: DRUG: Ifetroban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing a Nurse-led Advance Care Planning (ACP) Intervention in Residential Care Homes
Status: RECRUITING
Conditions: Advanced Care Planning
Interventions: BEHAVIORAL: Nurse-led Advance Care Planning (ACP) Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Different Platelet Concentrates After Gingivectomy and Gingivoplasty Evaluation of Its Effect on Early Wound Healing.
Status: COMPLETED
Conditions: Wound Heal|Gingival Overgrowth|Gingival Enlargement|Platelet Rich Fibrin
Interventions: OTHER: Control group|OTHER: PRF group|OTHER: CGF group|OTHER: AFG group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intranasal Remimazolam for Premedication in Pediatric Patient
Status: COMPLETED
Conditions: Sedative; Anxiety Disorder
Interventions: DRUG: Remimazolam|OTHER: Distilled water for injection|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy
Status: COMPLETED
Conditions: Obesity|Obesity, Morbid|Obesity; Endocrine|Bariatric Surgery Candidate
Interventions: PROCEDURE: Gastric mucosal devitalization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of OMP-54F28 in Combination With Paclitaxel and Carboplatin in Patients With Recurrent Platinum-Sensitive Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: OMP-54F28, Paclitaxel and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Once-Monthly Subcutaneous Mircera for the Treatment of Chronic Renal Anemia in Pre-Dialysis Patients Not Currently Treated With ESA.
Status: TERMINATED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia
Status: COMPLETED
Conditions: Falciparum Malaria
Interventions: DRUG: Artesunate|DRUG: Artesunate + Mefloquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Probiotics in Premature Infants
Status: TERMINATED
Conditions: Death|Nosocomial Infection
Interventions: DIETARY_SUPPLEMENT: Lactobacillus reuteri|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: End-to-End Compression Anastomosis for Left-sided Colectomy Endo-CAR Study
Status: COMPLETED
Conditions: Colorectal Cancer|Diverticulitis
Interventions: DEVICE: Niti CAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: weRISE: Youth-led Mental Health Transformation Through Cultivating Gratitude, Kindness, and Hope
Status: ENROLLING_BY_INVITATION
Conditions: Youth Mental Health
Interventions: BEHAVIORAL: weRISE; The gratitude, kindness and hope (GKH) program|BEHAVIORAL: The [adapted] Stan Kutcher Teen Mental Health (TMH) program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Curcumin for Women With Obesity and High Risk for Breast Cancer
Status: COMPLETED
Conditions: Atypical Ductal Breast Hyperplasia|BRCA1 Gene Mutation|BRCA2 Gene Mutation|Ductal Breast Carcinoma in Situ|Lobular Breast Carcinoma in Situ
Interventions: DIETARY_SUPPLEMENT: curcumin|OTHER: Biomarker analysis|OTHER: Assessment of Dietary Intake|OTHER: Daily Log
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Statin Mechanism Preventing Cardiovascular Disease by Post-hoc Analysis of Treating to New Targets Study
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects With Mild to Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: MMX Mesalamine/Mesalazine (Low Dose)|DRUG: MMX Mesalamine/Mesalazine (High Dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimalization of Nephroprotection Using N-Acetylcysteine
Status: COMPLETED
Conditions: Chronic Kidney Disease|Proteinuria
Interventions: DRUG: ACC (N-acetylcysteine) 1200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Anemia|Vitamin D Deficiency|Bone Diseases, Metabolic
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol|DIETARY_SUPPLEMENT: Olive oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Index Evaluation of a Hypercaloric/High-protein Nutritional Supplement in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Oral Nutritional Supplement|DIETARY_SUPPLEMENT: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Bioactivity of AXT107 in Subjects With Neovascular Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Neovascular Age-Related Macular Degeneration (nAMD)
Interventions: DRUG: AXT107 0.1 mg|DRUG: AXT107 0.25 mg|DRUG: AXT107 0.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOLFIRI and Sunitinib in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer|Liver Metastases
Interventions: DRUG: sunitinib added to FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadriceps Sparing Versus Standard Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Knee Arthroplasty
Interventions: PROCEDURE: Quads-Sparing Approach|PROCEDURE: Medial Para-Patellar Approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a New Anti-cancer Immunotherapy in Adult Acute Myeloid Leukemia Patients With a Suboptimal Clinical Response to Induction Chemotherapy
Status: COMPLETED
Conditions: Leukaemia, Myelocytic, Acute
Interventions: BIOLOGICAL: GSK Biologicals' recombinant WT1 Antigen-Specific Cancer Immunotherapeutic (ASCI) GSK2130579A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine +/- Imatinib Mesylate, Patients w/Previously Treated Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PDA for Antidepressant Use in Pregnancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Pregnancy|Depression
Interventions: BEHAVIORAL: Electronic Patient Decision Aid|BEHAVIORAL: Standard Resource Sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Butyrate in Pediatric Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Diseases
Interventions: DIETARY_SUPPLEMENT: sodium butyrate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Somatostatin Receptor Imaging in Acute Myocarditis and Cardiac Sarcoidosis
Status: RECRUITING
Conditions: Acute Myocarditis|Cardiac Sarcoidosis
Interventions: DIAGNOSTIC_TEST: 68Ga-DOTA-TOC PET/CT|BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ?
Status: UNKNOWN
Conditions: Rectocele|Intussusception|Surgery|Sphincter Ani Incontinence
Interventions: DEVICE: stapled transanal rectal resection|DEVICE: Anal compliance measure with Endoflip system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Inspiratory Muscle Training (IMT) on Balance Ability and Quality of Life of Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Inspiratory Muscle Training|DEVICE: Sham IMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH.
Status: UNKNOWN
Conditions: Metabolic Syndrome|HIV-1-infection|Glucose Intolerance|Dyslipidemias|Lipodystrophy|Lipoatrophy
Interventions: DRUG: Berberine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate an Oxaliplatin-based Chemotherapy in Patients With Resistant or Relapsing Non-Hodgkin Lymphoma.
Status: UNKNOWN
Conditions: Non-Hodgkin Lymphoma
Interventions: DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VNRX-7145 SAD/MAD Safety and PK in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: VNRX-7145|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PK Study Comparing Metformin Eicosapentaenoate to a Combined Dose of Metformin Hydrochloride and Ethyl Ester EPA
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent|Hypertriglyceridemia
Interventions: DRUG: Metformin Eicosapentaenoate|DRUG: Metformin HCl and Vascepa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Regimen of Bendamustin [B] Followed by GA101 and Ibrutinib [I] in CLL Patients
Status: COMPLETED
Conditions: Chronic Lymphocytic Leucemia
Interventions: DRUG: Bendamustine|DRUG: GA101|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients Suffering From a Progressive Pancreas Carcinoma With Everolimus (RAD001) and Gemcitabine
Status: COMPLETED
Conditions: Advanced or Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy of Two Siddha Drugs Sindhuvallathy Mezhugu and Kalladaippu Kudineer for Kidney Stones
Status: COMPLETED
Conditions: Urolithiasis
Interventions: DRUG: Sindhuvallathy mezhugu ( SVM)|DRUG: Kalladaippu Kudineer (KK) -
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: INTERVENCION Trial
Status: UNKNOWN
Conditions: Blood Pressure, High
Interventions: DRUG: Hydrochlorothiazide|DRUG: Amlodipine|DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperthermia With Chemotherapy for Locally Advanced or Metastatic Pancreas Cancer
Status: UNKNOWN
Conditions: Pancreatic Neoplasms
Interventions: DEVICE: Heckel Infrared Radiant Heat Device|OTHER: cisplatin, gemcitabine, interferon-alpha|OTHER: thermochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of ABCD in the Treatment of Cryptococcal Meningitis
Status: UNKNOWN
Conditions: Cryptococcal Meningitis
Interventions: DRUG: Amphotericin B Colloidal Dispersion|DRUG: flucytosine|DRUG: fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double Blind, Randomized, 3 Week Inpatient Study To Evaluate The Safety & Efficacy Of PF-02545920 Compared With Placebo
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: PF-02545920|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pro-omega-3, Reduction of Inflammation and Modulation of Prematurity
Status: UNKNOWN
Conditions: PPROM
Interventions: DIETARY_SUPPLEMENT: MAG-DHA|DIETARY_SUPPLEMENT: Oleic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
Status: UNKNOWN
Conditions: Oligoasthenoteratozoospermia|Male Infertility
Interventions: DRUG: Tab Tamoxifen 10 mg|DRUG: Tab Tamoxifen 10mg,Cap vitamin E 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of [14c]-Samidorphan (Also Known as ALKS 33) in Healthy, Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Samidorphan IV|DRUG: [14c]-Samidorphan sublingual|DRUG: [14c]-Samidorphan oral
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Staccato Loxapine (ADASUVE®) for Inhalation
Status: UNKNOWN
Conditions: Psychomotor Agitation|Schizophrenia|Bipolar Disorder
Interventions: DRUG: Inhaled loxapine|DRUG: Inhaled placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1403 and mRNA-1405 to Prevent Norovirus Acute Gastroenteritis in Healthy Adults 18 to 80 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Norovirus Acute Gastroenteritis
Interventions: BIOLOGICAL: mRNA-1403|BIOLOGICAL: mRNA-1405|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of WAL0921 in Patients With Glomerular Kidney Diseases
Status: RECRUITING
Conditions: Diabetic Nephropathies|Primary Focal Segmental Glomerulosclerosis|Minimal Change Disease|Primary Immunoglobulin A Nephropathy|Primary Membranous Nephropathy
Interventions: DRUG: WAL0921|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Inpatient Study Of The Efficacy, Safety, And Tolerability Of PF-02545920 In The Treatment Of Acute Exacerbation Of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-02545920|DRUG: PF-02545920|DRUG: Placebo|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Efficacy of AGA2118 in PostMenopausal Women wIth Low Bone MasS
Status: NOT_YET_RECRUITING
Conditions: Postmenopausal Osteoporosis
Interventions: DRUG: AGA2118|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Neoadjuvant Sutent for Patients With Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Sunitinib Malate (Sutent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Status: UNKNOWN
Conditions: Humoral Rejection|Guillain-Barre Syndrome|Miller Fisher Syndrome|CIDP|Good Pasture Syndrome|Hyperviscosity Syndrome
Interventions: DRUG: Fibrinogen concentrate|OTHER: Fresh Frozen Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: MBX-400|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erlotinib in Treating Patients With Stage III or Stage IV Pancreatic Cancer
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: erlotinib hydrochloride|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repertoire and Properties of Anti-drug Antibodies Involved in Immediate Hypersensitivity in the Operating Room
Status: RECRUITING
Conditions: Hypersensitivity, Immediate|Peri-operative Injury|Antibiotic Allergy|Antibody Hypersensitivity
Interventions: DIAGNOSTIC_TEST: IgG group|DIAGNOSTIC_TEST: IgE group|DIAGNOSTIC_TEST: IgG group + IgE group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of an Investigational Thermal Rehab Machine on Body Cooling in Hyperthermic Individuals
Status: COMPLETED
Conditions: Cryotherapy Effect
Interventions: DEVICE: Thermal Rehab Machine|OTHER: Forearm Ice Towels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome
Status: UNKNOWN
Conditions: Tourette Syndrome in Adolescence
Interventions: BEHAVIORAL: Behavioral testing on cognitive computerized tasks|OTHER: brain MRI|OTHER: TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the SilverHawk™ /TurboHawk™ Plaque Excision Systems Used With SpiderFX to Treat Calcified Peripheral Arterial Disease (DEFINITIVE Ca++)
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: SilverHawk™ LS-C, TurboHawk™ LS-C, TurboHawk™ LX-C plaque excision systems and SpiderFX™ embolic protection device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project Remission: Maximizing Outcomes With Intensive Treatments for Combat-Related PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: BEHAVIORAL: Massed Prolonged Exposure|BEHAVIORAL: Intensive Outpatient Prolonged Exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atropine Effects in Anaesthesia With Sufentanil vs. Remifentanil
Status: UNKNOWN
Conditions: Haemodynamic Fluctuations During Off-pump CABG.
Interventions: DRUG: Remifentanil|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy and Safety of Tecovirimat in Patients With Monkeypox Virus Disease
Status: RECRUITING
Conditions: Monkeypox|Mpox
Interventions: DRUG: Tecovirimat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Shared Decision-making: Effects on Cardiac Risk Factor Modification Behavior
Status: COMPLETED
Conditions: Coronary Artery Disease|Decision Making
Interventions: BEHAVIORAL: Decision Counseling Program (DCP)|BEHAVIORAL: Coronary Artery Disease Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of 1.5% Potassium Oxalate on the Control of Tooth Sensitivity and Color Change After Home Bleaching
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Carbamide Peroxide (PC) 22%) + placebo gel|OTHER: Carbamide Peroxide (PC) 22%) + Potassium Oxalate gel 1.5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Letrozole in Treating Breast Cancer in Postmenopausal Women With Stage I, II, or III Breast Cancer Previously Treated With Tamoxifen (GIM4)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Letrozole|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution With PREPOPIK® for Colon Cleansing in Preparation for Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation
Interventions: DRUG: Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution|DRUG: Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Albuferon With Ribavirin in Interferon Treatment Experienced Subjects With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Albuferon|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
Status: RECRUITING
Conditions: Pediatric Cancer
Interventions: DRUG: Ribociclib|DRUG: Topotecan|DRUG: Temozolomide|DRUG: Everolimus|DRUG: Adavosertib|DRUG: Carboplatin|DRUG: Olaparib|DRUG: Irinotecan|DRUG: Vistusertib|DRUG: Nivolumab|DRUG: Cyclophosphamide|DRUG: Selumetinib|DRUG: Enasidenib|DRUG: Lirilumab|DRUG: Fadraciclib|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Ceralasertib|DRUG: Futibatinib|DRUG: Capmatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct to Implant Breast Reconstruction Based Pre- or Retropectoral
Status: UNKNOWN
Conditions: Breast Reconstruction
Interventions: PROCEDURE: Retropectoral immediate breast reconstruction|PROCEDURE: Prepectoral immediate breast reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Continuation of Subcutaneous and Intramuscular Depot Medroxyprogesterone Acetate in Post-abortion Patients
Status: RECRUITING
Conditions: Contraception
Interventions: DRUG: Depot-Medroxyprogestereone Acetate|DRUG: Depot-Medroxyprogestereone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 5-Azacytidine With Lenalidomide in Patients With High Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: 5-Azacytidine|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Jaktinib In Patients With Myelofibrosis Who Were Relapsed or Refractory of Ruxolitinib Treatment.
Status: COMPLETED
Conditions: Myelofibrosis
Interventions: DRUG: Jaktinib Hydrochloride Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking
Status: RECRUITING
Conditions: Keratoconus|Cornea Ectasia
Interventions: DIETARY_SUPPLEMENT: Dietary riboflavin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Treatment of Acne Scarring
Status: COMPLETED
Conditions: ACNE SCARRING
Interventions: BIOLOGICAL: Autologous Human Platelet Lysate|BIOLOGICAL: Autologous Human Platelet Lysate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Patient Reported Outcomes (PROs) to Evaluate Teriflunomide Treatment in Relapsing Multiple Sclerosis (RMS) Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Teriflunomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mainstream Sleep Tracking Devices vs Polysomnography
Status: WITHDRAWN
Conditions: Severe Sleep Apnea|Severe Insomnia|Epileptiform Activity
Interventions: DEVICE: Polysomnography Data|DEVICE: Jawbone UP®|DEVICE: Fitbit Charge ®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Immobilization of the Shoulder in External Rotation Reduce the Recurrence Rate of Shoulder Dislocation?
Status: COMPLETED
Conditions: Shoulder Dislocation
Interventions: PROCEDURE: Arm1:Immobilization in external rotation|PROCEDURE: immobilization in internal rotation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Novel Sound Changing Principles in Hearing Instruments to Determine Their Application - 2019_33
Status: COMPLETED
Conditions: Hearing Loss
Interventions: DEVICE: Hearing Aid without Reverberation Canceller (RevC).|DEVICE: Hearing Aid Reverberation Canceller enabled (RevC_1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TEMPO Study: Trimethoprim-Sulfamethoxazole in Granulomatosis With Polyangiitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Granulomatosis With Polyangiitis|Wegener Granulomatosis
Interventions: DRUG: Trimethoprim Sulfamethoxazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis
Status: COMPLETED
Conditions: Upper Respiratory Tract Infection
Interventions: DRUG: Azithromycin SR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M-Tapa Block vs External Oblique Intercostal Block for Laparoscopic Sleeve Gastrectomy Surgery
Status: COMPLETED
Conditions: Anesthesia|Regional Anesthesia|Postoperative Pain
Interventions: PROCEDURE: Bilateral ultrasound guided external oblique intercostal block (EOIB)|PROCEDURE: Bilateral ultrasound guided Modified thoracoabdominal nerves block through perichondrial approach(M-TAPA) block|DRUG: IV morphine patient-controlled analgesia (PCA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osseous Setting Improvement With Co-implantation of Osseous Matrix and Mesenchymal Progenitors Cells From Autologous Bone Marrow
Status: SUSPENDED
Conditions: Tibia or Femur Pseudo-arthrosis
Interventions: PROCEDURE: Chirurgical procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
Status: ACTIVE_NOT_RECRUITING
Conditions: Depression|Depressive Symptoms|Mood
Interventions: DIETARY_SUPPLEMENT: vitamin D3|DRUG: omega-3 fatty acids (fish oil)|DIETARY_SUPPLEMENT: Fish oil placebo|DIETARY_SUPPLEMENT: Vitamin D placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Metformin as Adjuvant Therapy in Patients With Ulcerative Colitis
Status: UNKNOWN
Conditions: Ulcerative Colitis|Inflammatory Bowel Diseases
Interventions: DRUG: metformin 500 mg TID Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Evaluation of Intracoronary Infusion of Extracellular Vesicles in Patients Following Coronary Stent Implantation
Status: ENROLLING_BY_INVITATION
Conditions: Percutaneous Coronary Intervention
Interventions: DRUG: PEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)
Status: TERMINATED
Conditions: Postural Orthostatic Tachycardia Syndrome
Interventions: DRUG: Iron infusion|DRUG: Normal saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma|Ocular Hypertension
Interventions: PROCEDURE: Primary Selective Laser Trabeculoplasty Treatment Pathway|DRUG: Primary Medical Treatment Pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Pharmacokinetic Profiles of TRK-100STP in Japanese, Chinese, and South Korean Non-elderly Healthy Adult Males
Status: COMPLETED
Conditions: Healthy Adult Male|Pharmacokinetics of TRK-100-STP
Interventions: DRUG: TRK-100STP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Cardiovascular and Muscular Adaptations to Recreational Soccer and Strength Training in Elderly Healthy 65-75-year-old Men
Status: COMPLETED
Conditions: Adaptation Reaction
Interventions: OTHER: physical training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic Cancer
Status: RECRUITING
Conditions: Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Pancreatic Carcinoma
Interventions: DRUG: Bosentan|DRUG: Gemcitabine|DRUG: Nab-paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retention and Re-Engagement in Treatment for Addiction Following Serious Injection Related Infections (RETAIN)
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Bloodstream Infection|Osteomyelitis|Endocarditis|Septic Arthritis|Epidural Abscess
Interventions: OTHER: RETAIN|OTHER: Unrelated videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of (L-PRF) Membrane in The Treatment of Gingival Recession
Status: COMPLETED
Conditions: Localized Gingival Recession
Interventions: PROCEDURE: Leukocyte Platelet rich fibrin membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT