pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic, Persistent, Recurrent, or Progressive Solid Tumors
Status: TERMINATED
Conditions: Colorectal Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma|Recurrent Breast Carcinoma|Recurrent Colorectal Carcinoma|Recurrent Melanoma of the Skin|Recurrent Non-Small Cell Lung Carcinoma|Recurrent Pancreatic Carcinoma|Recurrent Renal Cell Carcinoma|Solid Neoplasm|Stage IV Breast Cancer|Stage IV Non-Small Cell Lung Cancer|Stage IV Renal Cell Cancer|Stage IV Skin Melanoma|Stage IVA Colorectal Cancer|Stage IVA Pancreatic Cancer|Stage IVB Colorectal Cancer|Stage IVB Pancreatic Cancer
Interventions: DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pegfilgrastim|OTHER: Pharmacological Study|DRUG: TLR8 Agonist VTX-2337
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wean Early With HFNCO vs NPPV in Patients With AHRF
Status: UNKNOWN
Conditions: Patients With Acute Hypoxemic Respiratory Failure
Interventions: DEVICE: High-Flow Nasal Cannula Oxygenation|DEVICE: Noninvasive Positive Pressure Ventilation|DEVICE: Conventional weaning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Correlation of FAZA PET Hypoxia Imaging To 3D Histology in Oral Tongue Cancer
Status: SUSPENDED
Conditions: Tongue Cancer
Interventions: RADIATION: (18)F-Fluoroazomycin arabinoside|DRUG: Pimonidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pain and Fatigue Management in Patients With Breast Cancer, Prostate Cancer, Colon Cancer, or Lung Cancer
Status: COMPLETED
Conditions: Breast Cancer|Colorectal Cancer|Fatigue|Lung Cancer|Pain|Prostate Cancer
Interventions: OTHER: educational intervention|OTHER: questionnaire administration|OTHER: study of socioeconomic and demographic variables|PROCEDURE: assessment of therapy complications|PROCEDURE: fatigue assessment and management|PROCEDURE: quality-of-life assessment|PROCEDURE: standard follow-up care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Chinese Auriculotherapy on Stress and Quality of Life in Nursing Professionals: Randomized Clinical Trial
Status: COMPLETED
Conditions: Stress|Quality of Life
Interventions: OTHER: Auriculotherapy (protocol group)|OTHER: without protocol group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Psychotherapy (Accelerated Resolution Therapy) for Cancer Related Trauma and Distress
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: BEHAVIORAL: Psychotherapy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment Individualisation by EBV Stratification in Nasopharyngeal Carcinoma: a Prospective Observational Study
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: OTHER: Arm 1|OTHER: Arm 2|OTHER: Arm 3|OTHER: Group 1|OTHER: Group 2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Transplant Targeted Against Crohn's
Status: WITHDRAWN
Conditions: Crohn's Disease
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Mesna|DRUG: Alemtuzumab|DRUG: G-CSF|DRUG: Rifaximin|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Plate Osteosynthesis of Fractures of the Lower Extremity of the Radius: Does the Systematic Use of Short Epiphysic Screws Limit the Posterior Protrusion of the Screws Without Compromising Stability
Status: UNKNOWN
Conditions: Fracture; Radius, Lower or Distal End
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Docetaxel for Injection (Albumin-bound) in Patients With Gastric Cancer
Status: RECRUITING
Conditions: Gastric Adenocarcinoma|Adenocarcinoma of Gastroesophageal Junction
Interventions: DRUG: Docetaxel for injection (Albumin-bound)|DRUG: Taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food as Medicine: An RCT to Study the Effect of Home Delivered, Medically Tailored Meals on Patients With Metastatic Cancer
Status: COMPLETED
Conditions: Quality of Life
Interventions: OTHER: Home Delivered, Medically Tailored Meals (HDTM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Use of Augmented Intelligence for the Interpretation of Bone Standard X-rays Prescribed by the Emergency Department (IMMEDIAT Urgences)
Status: RECRUITING
Conditions: Bone Fracture
Interventions: OTHER: Organization with AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Skeletal Muscle Contractility, Self-reported Pain and Tissue Sensitivity in Females With Neck/Shoulder Pain and Trapezius MFTrPs
Status: COMPLETED
Conditions: Myofascial Pain Syndrome
Interventions: PROCEDURE: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Study Assessing the Safety and Tolerability of CTX-4430 in Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: CTX-4430|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BLOOM: Behavioral Modification and Lorcaserin for Overweight and Obesity Management
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Lorcaserin 10 mg BID|DRUG: Matching Placebo BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: DEB|DEVICE: PTA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study to Assess the Safety and Immunogenicity of JCXH-221, an mRNA-based Broadly Protective COVID-19 Vaccine
Status: RECRUITING
Conditions: COVID-19|Infectious Disease
Interventions: BIOLOGICAL: JCXH-221|BIOLOGICAL: Active Comparator|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 10 Versus 20 Minutes Treatment of Human Pericardium With Glutaraldehyde in OZAKI Procedure
Status: COMPLETED
Conditions: Aortic Valve Surgery
Interventions: OTHER: Treatment of human pericardium with glutaraldehyde in OZAKI procedure|OTHER: Treatment of human aortic valve tissue with glutaraldehyde
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of ADCT-301 in Patients With Relapsed or Refractory Hodgkin and Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Hodgkin Lymphoma|Non-Hodgkin Lymphoma
Interventions: DRUG: Camidanlumab tesirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-4 (IL-4) as a Marker of Atherosclerosis
Status: WITHDRAWN
Conditions: Atherosclerosis|Ischemic Heart Disease
Interventions: PROCEDURE: Measuring IL-4 levels
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis
Interventions: OTHER: Specific Carbohydrate diet (SCD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Nutritional Eating Plan and Dietary Fibers in Adult Patients With HIV/AIDS
Status: COMPLETED
Conditions: Dietary Modification|Dyslipidemia|Signs and Symptoms, Digestive|HIV
Interventions: DIETARY_SUPPLEMENT: Symbiotic|DIETARY_SUPPLEMENT: Maltodextrin (placebo for symbiotic)|BEHAVIORAL: Nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Laparoscopic Gynecologic Surgery
Status: UNKNOWN
Conditions: Laparoscopic Gynecologic Surgery
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: S-1 and Photodynamic Therapy in Cholangiocarcinoma
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DRUG: S-1 Chemotherapy|PROCEDURE: Photodynamic therapy|PROCEDURE: Systemic chemotherapy except S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Characteristics and Predictors of Liver Injury in Cyclin-dependent Kinase Inhibitors 4/6 (CDK4/6)-Treated Patients With Advanced Breast Cancer
Status: COMPLETED
Conditions: DILI
Interventions: DRUG: Ribociclib, palbociclib, abemaciclib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma
Status: COMPLETED
Conditions: Relapsed or Refractory Medulloblastoma (MB), Neuroblastoma (NB), Ewing Sarcoma (ES) and Alveolar Rhabdomyosarcoma (ARMS)
Interventions: DRUG: TB-403 20mg/kg|DRUG: TB-403 50mg/kg|DRUG: TB-403 100mg/kg|DRUG: TB-403 175mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation Research of the Nutrition Interventions in the INHP II Areas of CARE India
Status: COMPLETED
Conditions: Underweight|Stunting|Wasting|Anemia
Interventions: BEHAVIORAL: Maternal nutrition and infant feeding advice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Insulin Resistance|Obesity|Cardiovascular Diseases|Cognitive Impairment|Physical Disability|Depression|Inflammation|Hormone Deficiency|Physical Inactivity|Hyperlipidemias|Hypertension|Overeating
Interventions: BIOLOGICAL: GLY-LOW
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Surgical Site Infections
Interventions: DRUG: Mupirocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Plasma Concentrations of Calcium, Phosphate, FGF23, Klotho, 25 (OH) D3 and 1,25 (OH) 2D3 From Patients Who Wants to Have Children
Status: UNKNOWN
Conditions: Infertility, Female
Interventions: DIAGNOSTIC_TEST: Plasma level of vitamin D
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Venetoclax in Combination With Isatuximab and Dexamethasone for Relapsed/Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma, Refractory
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Psychodrama for Skin Picking
Status: COMPLETED
Conditions: Excoriation of Skin
Interventions: BEHAVIORAL: Psychodrama Group Therapy (PGT)|BEHAVIORAL: Supportive Group Therapy (SGT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of CP-751,871 In Patients With Ewing's Sarcoma Family Of Tumors
Status: COMPLETED
Conditions: Ewing's Sarcoma Family of Tumors
Interventions: DRUG: CP-751,871
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Blended Care Intervention "Booster" for Youth With Chronic Health Conditions to Increase Fatigue-related Self-efficacy
Status: NOT_YET_RECRUITING
Conditions: Fatigue|Chronic Illnesses
Interventions: OTHER: Booster
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Texting to Reduce Alcohol Misuse Pilot Trial
Status: ENROLLING_BY_INVITATION
Conditions: Alcohol Consumption
Interventions: BEHAVIORAL: Control|BEHAVIORAL: Goal Support (GS)|BEHAVIORAL: Coaching for Context-specific Peer Support (CCPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post-marketing Safety Study of GSK Biological's Pediarix™ Vaccine
Status: COMPLETED
Conditions: Hepatitis B|Poliomyelitis|Diphtheria|Tetanus|Acellular Pertussis
Interventions: BIOLOGICAL: Pediarix|BIOLOGICAL: Licensed DTPa containing vaccine|BIOLOGICAL: Prevnar®: (Wyeth)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacokinetics of Fluzoparib in Healthy Subjects and Those With Impaired Kidney Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: Fluzoparib|DRUG: Fluzoparib|DRUG: Fluzoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Hormones + Docetaxel in Node-Positive Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Neoadjuvant Hormonal Therapy|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variables Influencing Anti-COVID-19 Vaccinations Around the World: an Analysis Conducted on Aggregated Data Sourced From Institutional Databases to Understand Whether and How Different Variables Could Affect the Vaccine Coverage (WORLDCOV: Worldwide Determinants of COVID-19 Vaccination)
Status: UNKNOWN
Conditions: COVID-19 Vaccines
Interventions: BIOLOGICAL: COVID-19 Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brachial Versus Femoral Access for Carotid Artery Stenting
Status: NOT_YET_RECRUITING
Conditions: Carotid Artery Stenosis Without Infarction (Disorder)|Ischemic Stroke
Interventions: PROCEDURE: Carotid Artery Stenting (CAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of COPD Exacerbation Recurrence
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive|COPD Exacerbation|Patient Readmission|Recurrence
Interventions: DIAGNOSTIC_TEST: Spirometry, Forced Oscillation Technique, Step-counter, sputum and blood samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair
Status: COMPLETED
Conditions: Physical Function|Pain|Hernia|Wound Infection|Postoperative Complication|Recurrence
Interventions: DEVICE: polypropylene mesh|DEVICE: Infinit® PTFE mesh (WL Gore)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined Interventions on Pressure Pain Threshold
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: PROCEDURE: end-range mobilization|PROCEDURE: Non end-range mobilization|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 4, 2012
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: TIV|BIOLOGICAL: High-Dose TIV|BIOLOGICAL: LAIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Safety and Efficacy of Istaroxime for Pre-Cardiogenic Shock
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiogenic Shock
Interventions: DRUG: Istaroxime|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PI or NNRTI as First-line Treatment of HIV in West Africa - the PIONA Trial
Status: COMPLETED
Conditions: HIV-1
Interventions: DRUG: Efavirenz or Nevirapine|DRUG: Ritonavir-boosted lopinavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multisystemic Therapy-Emerging Adults Trial
Status: COMPLETED
Conditions: Antisocial Behavior
Interventions: BEHAVIORAL: Multisystemic Therapy for Emerging Adults|BEHAVIORAL: Enhanced Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Pharmacokinetics of rhGAA in Siblings With Glycogen Storage Disease Type II
Status: COMPLETED
Conditions: Glycogen Storage Disease Type II|Pompe Disease|Acid Maltase Deficiency Disease|Glycogenosis 2
Interventions: DRUG: Alglucosidase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Tacrolimus and Sirolimus Immunosuppression Based Drug Regimens in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: DRUG: Anti-thymocyte globulin|DRUG: Mycophenolate mofetil|DRUG: Prednisone|DRUG: Tacrolimus|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine if Fibrin Affects the Ability of a Wound to Heal
Status: COMPLETED
Conditions: Effect of Test Articles on the Healing of a Wound Artificially Induced by Liquid Nitrogen Spray
Interventions: BIOLOGICAL: Fibrin|OTHER: White Petrolatum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avanzando Juntas: Adapting an Evidence Based Weight Loss Program for Hispanic Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Gynecologic Cancer
Interventions: BEHAVIORAL: Guided Lifestyle Program Intervention|BEHAVIORAL: Self-Guided Lifestyle Program (Control Arm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia (AML) in Complete Remission
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Oral Azacitidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of Video Discharge Instructions for Mohs Surgery Post-Operative Care
Status: TERMINATED
Conditions: Linear Closure|Surgery
Interventions: BEHAVIORAL: Video Discharge Instructions|BEHAVIORAL: Telecommunication Reminders|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Low Intensity 'Blue Light' Treatment of Seasonal Affective Disorder
Status: COMPLETED
Conditions: Seasonal Affective Disorder
Interventions: DEVICE: Blue enriched light with a low intensity|DEVICE: standard light treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Combination Therapy With S-1, Irinotecan, and Bevacizumab (SIRB) in Patients With Unresectable or Recurrent Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal, Cancer
Interventions: DRUG: S-1, Irinotecan, Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ovarian Damage in Young Premenopausal Women Undergoing Chemotherapy for Cancer
Status: WITHDRAWN
Conditions: Leukemia|Long-term Effects Secondary to Cancer Therapy in Adults|Long-term Effects Secondary to Cancer Therapy in Children|Lymphoma|Sexual Dysfunction and Infertility|Sexuality and Reproductive Issues|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: OTHER: laboratory biomarker analysis|PROCEDURE: fertility assessment and management|PROCEDURE: management of therapy complications|PROCEDURE: ultrasound imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Mobile Apps for Those With PTSD and Their Partners
Status: COMPLETED
Conditions: Ptsd
Interventions: BEHAVIORAL: Mobile App + Mailed Materials for managing stress associated with PTSD|BEHAVIORAL: Mobile App for managing stress associated with PTSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacytidine (Vidaza®) Versus Fludarabine and Cytarabine (Fluga Scheme) in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitadine|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Lenograstim|DRUG: Filgastrim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of IMPT-314 in R/R Aggressive B-cell NHL
Status: RECRUITING
Conditions: Relapsed Non-Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma
Interventions: DRUG: IMPT-314
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EBUS-TBNA Versus EBUS-TBNB
Status: WITHDRAWN
Conditions: Mediastinal Lymphadenopathy|Hilar Lymphadenopathy|Carcinoma|Lymphoma|Sarcoidosis|Mycobacterial Disease
Interventions: DEVICE: Endobronchial ultrasound guided lymph node sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Timolol on Refractive Outcomes in Eyes With Myopic Regression After LASIK: a Randomized Clinical Trial
Status: COMPLETED
Conditions: Myopic Regression
Interventions: DRUG: Timolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neutrophil Elastase, Elastase Alpha-1 Proteinase, Periodontitis, Gingival Crevicular Fluid and Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Periodontitis
Interventions: PROCEDURE: Non-Surgical Periodontal Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Pain Evaluation of Mineral Trioxide Aggregate and Propolis After Pulpotomy in Carious Primary Molars
Status: UNKNOWN
Conditions: Pulp Disease, Dental
Interventions: DRUG: Propolis|DRUG: Mineral Trioxide Aggregate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin and ZD1839 + Re-Irradiation in Recurrent Squamous Cell Cancer of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer|Carcinoma, Squamous Cell
Interventions: DRUG: ZD-1839|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repair of Flexor Tendon Injuries With Eight Strand Core Stitch Without Postoperative Splinting
Status: UNKNOWN
Conditions: Flexor Tendon Repair
Interventions: PROCEDURE: Absorbable polydioxanone suture (PDS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters
Status: RECRUITING
Conditions: Neurogenic Bladder
Interventions: DRUG: Culturelle 10 Billion CFU Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Differences Between Patients With Vascular Parkinsonism and Parkinson's Disease
Status: COMPLETED
Conditions: Vascular Parkinsonism|Parkinson's Disease
Interventions: DIAGNOSTIC_TEST: Neuro-radiological tools:|DIAGNOSTIC_TEST: cognitive tests|DIAGNOSTIC_TEST: lab investigations|DIAGNOSTIC_TEST: Beck depression inventory (BDI)(Arabic version)|DIAGNOSTIC_TEST: Clinical Tools for Urinary symptoms:|DIAGNOSTIC_TEST: Freezing of gait questionnaire|DIAGNOSTIC_TEST: non-motor symptoms scales (NMSS).|DIAGNOSTIC_TEST: Movement Disorders Society- Unified Parkinson's Disease Rating Scale (MDS-UPDRS):|DIAGNOSTIC_TEST: ELIZA for alpha-synuclein|OTHER: transcranial color-coded duplex(TCCD)|OTHER: extracranial carotid duplex|OTHER: The Arabic version of Parkinson's Disease Questionnaire( PDQ-39)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lidocaine for Pessary Check Pain Reduction
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Stress Urinary Incontinence
Interventions: DRUG: Lidocaine Hcl 2% Jelly|DRUG: Placebo Jelly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Semi-rigid and Flexible Catheters for Less Invasive Surfactant Administration in Preterm Infants
Status: COMPLETED
Conditions: Neonatology|Perinatal Distress Syndrome
Interventions: DEVICE: Surfactant Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ranibizumab Administered Monthly or on an As-needed Basis in Patients With Subfoveal Neovascular Age-related Macular Degeneration (HARBOR)
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib for Early Lung Dysfunction After Hematopoietic Stem Cell Transplant
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplant (HSCT)|Bronchiolitis Obliterans (BO)
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Injectable-Platelet Rich Fibrin (i-PRF) in the Lower Third Molar Extraction
Status: ACTIVE_NOT_RECRUITING
Conditions: Molar, Third|Postoperative Complications
Interventions: PROCEDURE: Extraction of mandibular third molar|DEVICE: i-PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Pharmacokinetics of KBPA-101 in Hospital Acquired Pneumonia Caused by O11 Pseudomonas Aeruginosa
Status: COMPLETED
Conditions: Pneumonia|Ventilator Associated Pneumonia
Interventions: BIOLOGICAL: KBPA-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NO Donors and Inhibitors to Study Imbalance of Nitrogen Stress and Antioxidant Defense in COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Aminoguanidine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Trial: Myocardial Injury After Noncardiac Surgery (MINS) Following Radical Prostatectomy
Status: RECRUITING
Conditions: Myocardial Injury
Interventions: DIAGNOSTIC_TEST: Pre- and postoperative determination of troponin as part of the study and 24-month FU survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.
Status: RECRUITING
Conditions: Vulvar Cancer|Cervical Cancer|Vulvar Dysplasia|Cervical Dysplasia|Anal Cancer|Anal Dysplasia|HPV-Related Anal Squamous Cell Carcinoma
Interventions: PROCEDURE: Screening anal Pap smear - No high-resolution anoscopy|PROCEDURE: Screening anal Pap smear - High-resolution anoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: ME-401 and R-CHOP in Newly Diagnosed Diffuse Large B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: ME-401|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation
Status: TERMINATED
Conditions: Heart Defects, Congenital
Interventions: DRUG: Dexrazoxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Immune Response to Two HIV Vaccine Regimens in Healthy, HIV-Uninfected Adults in the United States and South Africa
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: BIOLOGICAL: DNA-HIV-PT123 vaccine|BIOLOGICAL: NYVAC-HIV-PT1 vaccine|BIOLOGICAL: NYVAC-HIV-PT4 vaccine|BIOLOGICAL: AIDSVAX B/E vaccine|BIOLOGICAL: Placebo for DNA/NYVAC/AIDSVAX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The STREAM Percutaneous Coronary Intervention Anticoagulant Sub-study
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: enoxaparin|DRUG: Unfractionated heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diluted and Undiluted Enteral Nutrition
Status: NOT_YET_RECRUITING
Conditions: Critical Illness|Surgery|Enteral Feeding Intolerance|Gastro-Intestinal Disorder|Quality of Life
Interventions: OTHER: Enteral fluid|OTHER: Intravenous fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of AK104/Placebo Plus AK109/Placebo And Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Gastric and Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: cadonilimab|DRUG: pulocimab|DRUG: paclitaxel|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arginine Synthesis in Healthy Adult Humans
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: 2-15N glutamine|OTHER: 15N2 arginine and 15N proline|OTHER: 1-13C glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 1b Safety, Tolerability, and PK Study to Assess GS-5737 in Subjects With CF
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: GS-5737|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Observational Study on the Carotid Intima-media Thickness in Patients Undergoing Thyroid Surgery
Status: RECRUITING
Conditions: Plummer Disease|Multinodular Goiter|Graves Disease|Hyperthyroidism|Euthyroid Goiter|Thyroid Cancer|Basedow Disease
Interventions: OTHER: Experimental
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ezetimibe and Atorvastatin Therapy on TCFA
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Ezetimibe and Atorvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Digital Game Addiction in Adolescents
Status: UNKNOWN
Conditions: Digital Technology|Behavior, Addictive|Adolescent|Motivation
Interventions: BEHAVIORAL: Training based on IMB model, motivational interview technique, hippotherapy program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Shire SCT: Lisdexamfetamine Treatment for ADHD and SCT
Status: COMPLETED
Conditions: Attention Deficit Disorder|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Lisdexamfetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Compression Garments on Pain in Patients With Complex Regional Pain Syndrome of the Upper Limbs.
Status: RECRUITING
Conditions: Complex Regional Pain Syndromes
Interventions: DEVICE: usual treatment with compression garments (CERECARE)|OTHER: usual treatment without compression garments (CERECARE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0106B Studying Bone Marrow Samples From Women With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: gene expression analysis|OTHER: flow cytometry|OTHER: fluorescence activated cell sorting|OTHER: laboratory biomarker analysis|OTHER: medical chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Efficacy and Quality of Life of Long-Acting Methylphenidate in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Long-Acting Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Stress Urinary Incontinence: Laparoscopic Obturator Urethropexy vs Burch Urethropexy
Status: WITHDRAWN
Conditions: Stress Urinary Incontinence
Interventions: PROCEDURE: Laparoscopic Obturator Urethropexy|PROCEDURE: Burch Urethropexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Mild Cognitive Impairment or Alzheimer's Dementia
Status: RECRUITING
Conditions: Alzheimer Disease|Anxiety|Agitation,Psychomotor
Interventions: DRUG: high CBD/low THC sublingual solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GDC-0810 Single Agent or in Combination With Palbociclib and/or a Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Women With Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: GDC-0810|DRUG: LHRH Agonist|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes
Status: ACTIVE_NOT_RECRUITING
Conditions: Lynch Syndrome|Hereditary Colonic Polyposis Syndromes
Interventions: GENETIC: colonic biopsies|GENETIC: questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RSA-RCT: Attune S+ TKA Versus Sigma TKA
Status: RECRUITING
Conditions: Osteoarthritis Arthritis|Joint Disease|Musculoskeletal Disease|Rheumatic Diseases
Interventions: DEVICE: ATTUNE S+ Knee Prosthesis by DePuy|DEVICE: PFC Sigma Knee Prosthesis by DePuy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns
Status: COMPLETED
Conditions: Second-degree Burn
Interventions: DRUG: Nanocrystalline silver|DRUG: Silver Sulfadiazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Riociguat in Children With Pulmonary Arterial Hypertension (PAH)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension, Pulmonary
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ArmeoSenso - Home Therapy and Assessment for Patients With Arm Impairments Based on Wearable Movement Sensors
Status: COMPLETED
Conditions: Stroke|Spinal Cord Injury
Interventions: DEVICE: ArmeoSenso
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atomoxetine Phase 2 Study in Japanese Adult Patients With Attention Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect on Decreasing Chemotherapeutic Toxicity and Increasing Anti-tumor Effect of Chinese Herbs Based on Syndrome Differentiation
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: standard chemotherapy medicine combined with Chinese herbs|DRUG: standard chemotherapy medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Pronation Versus Supination Maneuvers for the Reduction of the Pulled Elbow
Status: UNKNOWN
Conditions: Nursemaid Elbow|Pulled Elbow
Interventions: OTHER: Pronation|OTHER: Supination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Health in Work - a Measure for Increased Coping and Work Inclusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Musculoskeletal Pain|Mental Health Wellness 1|Work-Related Condition
Interventions: OTHER: Health and work environment information and processes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Asian Clinical Evaluation of an Investigational Contact Lens for Cosmetic Effect
Status: COMPLETED
Conditions: Cosmetic Appearance
Interventions: DEVICE: nelfilcon A contact lens with print|DEVICE: etafilcon A contact lens with print
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Decreased T1 Times and Impaired Myocardial Contractility in Anabolic Androgenic Steroids Users
Status: COMPLETED
Conditions: Focal Fibrosis
Interventions: DIAGNOSTIC_TEST: Cardiovascular Magnetic Resonance|DIAGNOSTIC_TEST: Transthoracic echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Semen Characteristics After 9 Months of Daily Tadalafil 20 mg
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: tadalafil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antineoplaston Therapy in Treating Children With Recurrent or Refractory High-Grade Glioma
Status: TERMINATED
Conditions: High Grade Glioma
Interventions: DRUG: Antineoplaston therapy (Atengenal + Astugenal)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Hepatitis B Vaccine Response Through the Use of a Topical Immune Modulator
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Resiquimod gel|BIOLOGICAL: Resiquimod gel|BIOLOGICAL: Resiquimod gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Histological and Volumetric Evaluation of Customized Allograft Bone Blocks
Status: RECRUITING
Conditions: Alveolar Bone Resorption|Graft Overgrowth|Resorption of Bone Graft|Graft Complication|Block
Interventions: PROCEDURE: Customized allogenic bone block surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Non Inferiority of the Thoracic Bi-block in Comparison With Thoracic Epidural for VATS.
Status: COMPLETED
Conditions: Erector Spinae Muscle Plane Block|Serratus Anterior Muscle Plane Block|Video-Assisted Thoracic Surgery|Lung Cancer|Pleural Diseases|Thoracic Epidural|Analgesia|Enhanced Recovery After Surgery
Interventions: PROCEDURE: Thoracic Regional Analgesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Protein Dose-repsonse Effect on GLP-1, PYY and Appetite in Male Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: OTHER: Dose-reponse effect of protein on appetite and appetite-regulating hormones
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Allo HSCT Using RIC for Hematological Diseases
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia|Chronic Myelogenous Leukemia|Plasma Cell Leukemia|Myelodysplastic Syndromes|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|B-Cell Lymphoma|Follicular Lymphoma|Lymphoplasmacytic Lymphoma|Mantle-Cell Lymphoma|Prolymphocytic Leukemia|Lymphoblastic Lymphoma|Burkitt's Lymphoma|Non-Hodgkin's Lymphoma|Multiple Myeloma|Myeloproliferative Syndromes|Hematological Diseases
Interventions: DRUG: Allopurinol|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: ATG|RADIATION: TBI|DRUG: Tacrolimus|DRUG: MMF|BIOLOGICAL: Peripheral Blood Stem Cells|BIOLOGICAL: Related or Unrelated Bone Marrow Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Radiotherapy for Recurrent DIPG
Status: COMPLETED
Conditions: Recurrent Diffuse Intrinsic Pontine Glioma
Interventions: RADIATION: Hypofractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Chemotherapies Associated With Targeted Therapies on the Resection Rate of Hepatic Metastases
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: Folinic Acid|DRUG: 5-FU|DRUG: Irinotecan|DRUG: Irinotecan|DRUG: Bevacizumab|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TBE (Tick-borne Encephalitis) Vaccination in Allergic Patients
Status: COMPLETED
Conditions: Vaccine Responsiveness in Allergy|Vaccine Responsiveness During Allergy De-sensitization Treatment
Interventions: BIOLOGICAL: TBE booster vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-postitive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Alpelisib|DRUG: Fulvestrant|DRUG: Alpelisib-matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Manual Therapy on Activation of the Descending Pain Inhibitory System in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Musculoskeletal Manipulations|Osteoarthritis, Knee
Interventions: OTHER: Mulligan mobilization|OTHER: AP Maitland mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT