pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Prevention of Hernia After Loop Ileostomy Reversal
Status: RECRUITING
Conditions: Loop Ileostomy
Interventions: COMBINATION_PRODUCT: Mesh reinforcement|OTHER: No reinforcement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Use of Cap in Improving the Performance of Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DEVICE: Cap (Olympus Medical Systems: D-201-15004, D-201-14304 and D-201-12704)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Trial of Healthy Together ("Juntos")
Status: NOT_YET_RECRUITING
Conditions: Obesity|Activity, Motor|Diet, Healthy
Interventions: BEHAVIORAL: Healthy Together ("Juntos")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth
Status: COMPLETED
Conditions: Post-Partum Haemorrhage
Interventions: BEHAVIORAL: E-MOTIVE intervention|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Single Dose GHB16L2 Trivalent Influenza Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: GHB16L2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Toll-like Receptor Agonist as an Adjuvant to Tumor Associated Antigens (TAA) Mixed With Montanide ISA-51 VG With Bevacizumab for Patients With Recurrent Glioblastoma
Status: WITHDRAWN
Conditions: Glioblastoma|Glioma
Interventions: DRUG: Bevacizumab|BIOLOGICAL: Peptide Vaccine|DRUG: Poly-ICLC as immune adjuvant|DRUG: Keyhole limpet hemocyanin (KLH)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Drug-drug Interactions of Sisunatovir in Healthy Adult Participants
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: DRUG: Itraconazole|DRUG: Verapamil|DRUG: Rifampicin|DRUG: Midazolam|DRUG: Placebo for RV521|DRUG: RV521
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Response to Treatment and Safety of 0.03% Tacrolimus (FK506) Ointment Administered in Pediatric Patients With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: tacrolimus ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ciprofol Versus Propofol in Patients Undergoing Painless Hysteroscopy
Status: NOT_YET_RECRUITING
Conditions: Painless Hysteroscopy
Interventions: DRUG: Ciprofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of a Timolol Releasing Intraocular Implant in Subjects With Primary Open-angle Glaucoma
Status: RECRUITING
Conditions: Primary Open-angle Glaucoma
Interventions: DRUG: TimoD implant|DEVICE: Injector system
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mesalamine for Uncomplicated Diverticular Disease: a Randomized, Double-blind, Placebo-controlled Study
Status: COMPLETED
Conditions: Colonic Diverticulosis
Interventions: DRUG: Mesalamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olaparib in Locally Advanced ER, PgR and HER2 Negative (Triple Negative) and in Locally Advanced Germline BRCA Mutation-positive Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: DRUG: olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Pharmacokinetics of GLA5PR Tablet According to the Renal Function
Status: UNKNOWN
Conditions: Neuropathic Pain
Interventions: DRUG: GLA5PR tablet 75 mg|DRUG: GLA5PR tablet 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality
Status: COMPLETED
Conditions: Systolic Heart Failure|Iron Deficiency
Interventions: DRUG: Iron|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide in Treating Young Patients With Relapsed or Refractory Solid Tumors or Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Childhood Myelodysplastic Syndromes|de Novo Myelodysplastic Syndromes|Previously Treated Myelodysplastic Syndromes|Refractory Anemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Ringed Sideroblasts|Refractory Cytopenia With Multilineage Dysplasia|Secondary Myelodysplastic Syndromes|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sleep Restriction on Female Soccer Players: Physical Performance, Muscle Damage, Inflammation, and BDNF Levels.
Status: RECRUITING
Conditions: Sleep|Sleep Restriction
Interventions: PROCEDURE: Sleep restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of I10E in the Maintenance Treatment of Patients With CIDP: Extension of PRISM Study I10E-1302
Status: TERMINATED
Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Interventions: DRUG: I10E
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia
Status: NOT_YET_RECRUITING
Conditions: Relapsed/Refractory KMT2A-r Acute Leukemia|Relapsed/Refractory NUP98-r Acute Leukemia|Relapsed/Refractory NPM1-m Acute Leukemia
Interventions: DRUG: Ziftomenib|DRUG: Cytarabine|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erlotinib Hydrochloride in Preventing Liver Cancer in Patients With Cirrhosis of the Liver
Status: COMPLETED
Conditions: Cirrhosis|Hepatocellular Carcinoma
Interventions: DRUG: Erlotinib|DRUG: Erlotinib Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A SU2C Catalyst® Trial of a PD1 Inhibitor With or Without a Vitamin D Analog for the Maintenance of Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Pancreas Adenocarcinoma|Advanced Pancreatic Cancer|Metastatic Pancreatic Cancer|Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Pembrolizumab|DRUG: paricalcitol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study Of An Oral Drug Called A Radiation Sensitizer In Patients With Newly Diagnosed Small Cell Lung Cancer (SCLC)
Status: COMPLETED
Conditions: Lung Cancer, Small Cell|Small Cell Lung Cancer
Interventions: DRUG: topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study to Investigate the Safety and Efficacy of Fermagate and Sevelamer Hydrochloride
Status: TERMINATED
Conditions: Chronic Kidney Failure
Interventions: DRUG: Fermagate|DRUG: Sevelamer hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Premature Rupture of Membranes at 34 to 37 Weeks' Gestation
Status: UNKNOWN
Conditions: Premature Rupture of Membrane
Interventions: PROCEDURE: induction of labor|PROCEDURE: follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hand Grip Strength in Athletic and Non-Athletic Girls at Different Phases of Menstrual Cycle
Status: COMPLETED
Conditions: Grip|Athlete|Non-athlete|Menstrual Cycle
Interventions: DEVICE: Hydraulic hand dynamometer (Jamar, Product model J00105, U.S.A)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Double Blind Placebo Study of JARDIANCE® (Empagliflozin) in Prehypertensives Type II Diabetics
Status: UNKNOWN
Conditions: Hypertension|Type II Diabetes
Interventions: DRUG: empagliflozin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Lu AA21004 on Cognitive Dysfunction in Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: vortioxetine (Lu AA21004)|DRUG: Duloxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Expectations on Hypoalgesia Produced by Mental Practice
Status: UNKNOWN
Conditions: Cognitive Change
Interventions: BEHAVIORAL: Positive Expectations (initial)|BEHAVIORAL: Negative Expectations (initial)|BEHAVIORAL: Neutral Expectations (initial)|BEHAVIORAL: Positive Expectations (during intervention)|BEHAVIORAL: Experimental: Negative Expectations (during intervention)|BEHAVIORAL: Neutral Expectations (during intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of a Probiotic Lozenge (Inersan) in Patients With Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: Probiotic (Inersan)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of a Group B Streptococcus Vaccine in Non-pregnant Women 18-40 Years of Age.
Status: COMPLETED
Conditions: Infection by Streptococcus Group B
Interventions: BIOLOGICAL: GBS-NN vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Autologous Immune Cell Therapy in Primary Hepatocellular Carcinoma Patients Following Resection and TACE Therapy
Status: COMPLETED
Conditions: Primary Hepatocellular Carcinoma
Interventions: BIOLOGICAL: DC-TC+GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA
Status: RECRUITING
Conditions: Pain Postoperative|Osteoarthritis|Total Knee Arthroplasty
Interventions: DRUG: Mirogabalin|DRUG: Pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Postoperative Pain After Total Hip Arthroplasty Using Intravenous Lidocaine Infusion
Status: WITHDRAWN
Conditions: Postoperative Pain Management After Total Hip Arthroplasty
Interventions: DRUG: Lidocaine|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Switch to DOVATO in Patients Suppressed on Biktarvy (SOUND)
Status: ACTIVE_NOT_RECRUITING
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Dolutegravir/Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Focal Epilepsy
Interventions: DRUG: XEN1101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Enhancement - Acute Decompensated Heart Failure and OSA
Status: RECRUITING
Conditions: Acute Decompensated Heart Failure|Obstructive Sleep Apnea|Motivational Enhancement|PAP Adherence
Interventions: BEHAVIORAL: Telemedicine Intensive Motivational Enhancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Two Different Self-Assessment Methods for Fetal Movement Monitoring on Maternal Psychosocial Status
Status: RECRUITING
Conditions: Fetal Movement|Mental Health Issue
Interventions: BEHAVIORAL: Mindfetalness|BEHAVIORAL: Sadovsky
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients
Status: RECRUITING
Conditions: Acute Kidney Injury|Liver Transplant; Complications
Interventions: DRUG: Terlipressin|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Legumes vs Corn-soy Flour on Environmental Enteric Dysfunction in Rural Malawian Children 6-11 Months
Status: COMPLETED
Conditions: Enteropathy
Interventions: DIETARY_SUPPLEMENT: Cow pea complementary food|DIETARY_SUPPLEMENT: Corn soy flour|DIETARY_SUPPLEMENT: Common bean
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: PSMA PET/CT vs. mpMRI in Patients With a High Suspicion of Prostate Cancer: a Head to Head, Parallel, Prospective Trial
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: PSMA PET/TRUS (trans-rectal or trans-perineal) fusion biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Xarelto on Prevention of Stroke and Noncentral Nervous System Systemic Embolism in Treatment-naïve Asian Patients With Non-valvular Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Steady State Meloxicam on Low Dose Aspirin Induced Inhibition of Platelet Aggregation and Thromboxane Synthesis in Healthy Males and Females
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Meloxicam|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quantitative US for Evaluation of Hepatic Steatosis in NAFLD
Status: COMPLETED
Conditions: Fatty Liver|Fatty Liver, Nonalcoholic
Interventions: DIAGNOSTIC_TEST: Quantitative US (Samsung Medison, RS85A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED)
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Rocuronium 0.6 mg/kg intubating dose|DRUG: Rocuronium 0.9 mg/kg intubating dose|DRUG: Rocuronium 0.1 mg/kg maintenance dose|DRUG: Rocuronium 0.15 mg/kg maintenance dose|DRUG: Rocuronium 0.2 mg/kg maintenance|DRUG: Vecuronium 0.1 mg/kg intubating dose|DRUG: Vecuronium 0.025 mg/kg maintenance dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Radial Shockwave Therapy for Treatment of Pain in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Extracorporeal Radial shockwaves|DEVICE: Placebo Radial Shockwaves
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Dense Therapy and Bevacizumab in Solid Tumors and Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: bevacizumab|DRUG: capecitabine|DRUG: irinotecan hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrathecal Morphine vs. US-Guided Bilateral Posterior Quadratus Lumborum Block in Cesarean Section
Status: RECRUITING
Conditions: Anesthesia|Postoperative Pain
Interventions: PROCEDURE: Intrathecal Morphine (ITM)|PROCEDURE: Quadratus Lumborum II (QLB-II) Block
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sintilimab Combined With GEMOX ± IBI305 (Bevacizumab Biosimilar) Versus GEMOX in Advanced Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Sintilimab|DRUG: IBI305|DRUG: GEMOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to See How BIIB122 Works in the Human Body, and to Evaluate it's Safety, and Tolerability in Healthy Adult Japanese, Chinese, and Caucasian Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: BIIB122
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase-I Study of a Nanoparticle-based Peptide Vaccine Against SARS-CoV-2
Status: COMPLETED
Conditions: Coronavirus|SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: LD Vehicle-GNP|BIOLOGICAL: LD PepGNP-Covid19|BIOLOGICAL: HD Vehicle-GNP|BIOLOGICAL: HD PepGNP-Covid19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Definitive Therapy for Oligometastatic Solid Malignancies
Status: UNKNOWN
Conditions: Stage IV or Recurrent Carcinoma or Sarcoma
Interventions: PROCEDURE: Complete Surgical Removal|RADIATION: Stereotactic Radiosurgery|RADIATION: Ablative external beam radiation dose|PROCEDURE: Subtotal surgical removal plus ablative radiation dose|RADIATION: Radioembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation
Status: COMPLETED
Conditions: Apnea of Prematurity|Respiratory Distress Syndrome
Interventions: DEVICE: Discontinue NCPAP after weaning pressures|DEVICE: Discontinue NCPAP without weaning pressures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Stereotactic Ablative Radiotherapy for Oligometastatic Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: Radical Radiotherapy (Conventional RT and SABR)|OTHER: Non-investigational SACT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery
Status: UNKNOWN
Conditions: Elderly|Orthopedic Surgery|Analgesia|Dexmedetomidine|Postoperative Delirium|Long-term Outcome
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Beta-blockade Effects on Memory for Cocaine Craving
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Propranolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Age Related Macular Degeneration
Interventions: DEVICE: LT-300 Active (PBM)|DEVICE: LT-300 Inactive (Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Norwegian Laparoscopic Aortic Surgery Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortobifemoral Bypass|Aortoiliac Occlusive Disease|TASC Type D Lesions|Laparoscopic Versus Open Bifurcation Graft
Interventions: PROCEDURE: Laparoscopic aortobifemoral bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acupuncture-tDCS Convergence Rehabilitation Effect on Stroke Patients
Status: COMPLETED
Conditions: Stroke, Acute
Interventions: DEVICE: Electrical acupuncture|DEVICE: Acupuncture|DEVICE: tDCS|DEVICE: sham tDCS|OTHER: NDT-Bobath Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How COVID-19 Effects to Muscle Mass Change ın ICU?
Status: COMPLETED
Conditions: SARS-CoV-2 Acute Respiratory Disease|Sarcopenia|ICU Acquired Weakness|Critical Illness Myopathy
Interventions: OTHER: COVID-19 RELATED MUSCLE MASS CHANGE IN THE INTENSIVE CARE UNIT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating Predictors & Interventions in Sphincter of Oddi Dysfunction
Status: COMPLETED
Conditions: Sphincter of Oddi Dysfunction
Interventions: PROCEDURE: ERCP with sphincterotomy|PROCEDURE: ERCP without sphincterotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Tolerability of a Seasonal Influenza Vaccine Containing LIQ001
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone® (2010/2011 Inactivated Trivalent Influenza Vaccine)|BIOLOGICAL: LIQ001 (0.45mg)|BIOLOGICAL: LIQ001 (1.8mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Improved Quality of Life in Children With Intestinal Failure
Status: COMPLETED
Conditions: Intestinal Pseudo-Obstruction|Short Bowel Syndrome|Malabsorption Syndrome Autoimmune Enteropathy|Bacterial Overgrowth
Interventions: DIETARY_SUPPLEMENT: Stimulance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Depression Treatment Following Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Cardiovascular Diseases|Coronary Disease|Heart Diseases|Depression
Interventions: BEHAVIORAL: Psychoeducation; Treatment recommendations|DRUG: Pharmacotherapy|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence
Status: TERMINATED
Conditions: Insomnia|Alcohol Use Disorder
Interventions: DRUG: Suvorexant 20 mg|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: Psilocybin|BEHAVIORAL: Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Denervation for the Treatment of Hypertension: A Pilot Safety and Efficacy Study
Status: UNKNOWN
Conditions: Hypertension
Interventions: DEVICE: Radio frequency renal denervation system (Golden Leaf GL-06E15A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eus-giuded Biliary Drainage With Ec-lams vs ERCP as a Primary Intervention for Endoscopic Treatment of Patinets With Distal Malignant Biliary Obstruction
Status: COMPLETED
Conditions: DISTAL MALIGNANT BILIARY OBSTRUCTION
Interventions: PROCEDURE: ERCP|PROCEDURE: EUS-BD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Lifestyle Factors in Breast Cancer-Related Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7
Interventions: OTHER: Behavioral, Psychological or Informational Intervention|OTHER: Best Practice|OTHER: Cognitive Intervention|OTHER: Computer-Assisted Intervention|OTHER: Counseling|BEHAVIORAL: Exercise Intervention|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA)
Status: COMPLETED
Conditions: Urethritis
Interventions: DRUG: Azithromycin|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HER2-PREDICT: Translational Study of Tumor Samples From Patients Treated With Trastuzumab Deruxtecan (T-DXd; DS-8201a)
Status: RECRUITING
Conditions: Metastatic Cancer
Interventions: OTHER: Tumor and Blood sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Suvorexant on Sleep, Stress, and Cue-reactivity in Methamphetamine Use Disorder
Status: TERMINATED
Conditions: Methamphetamine Use Disorder
Interventions: DRUG: SUVO|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA
Status: RECRUITING
Conditions: Dementia|Alzheimer Disease|Caregiver Burnout|Family Members
Interventions: BEHAVIORAL: Tele-STELLA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of TQB2450 Combined With Anlotinib in Subjects With Gynecological Cancer
Status: UNKNOWN
Conditions: Gynecological Cancer
Interventions: DRUG: TQB2450|DRUG: Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Per-cutaneous Intervention Based Paclitaxel and Sirolimus-Eluting Versus Bare Stents for the Treatment of de Novo Coronary Lesions (PAINT)
Status: COMPLETED
Conditions: Coronary Restenosis
Interventions: DEVICE: Milennium Matrix® (Control)|DEVICE: Infinnium®|DEVICE: Supralimus®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of KPL-404 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: KPL-404|OTHER: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prospective Comparative Study for Patients With Biochemical Recurrence Prostate Cancer Detecting by 18F-JK-PSMA-7
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer|18F- Fluorocholine|PSMA PET|Radiotherapy|Prostatectomy|Tumor of Prostate
Interventions: DRUG: Radiopharmaceutical 18F-JK-PSMA-7|DRUG: Radiopharmaceutical 18F-Fluorocholine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Morphine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of XNW4107 in Subjects With Various Degrees of Renal Function
Status: COMPLETED
Conditions: Bacterial Infections
Interventions: DRUG: XNW4107, Imipenem/Cilastatin|DRUG: XNW4107, Imipenem/Cilastatin|DRUG: XNW4107, Imipenem/Cilastatin|DRUG: XNW4107, Imipenem/Cilastatin|DRUG: XNW4107, Imipenem/Cilastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy and Safety Study of ALbumin Therapy in Acute Ischemic Stroke
Status: TERMINATED
Conditions: Cerebral Infarction
Interventions: BIOLOGICAL: Human Serum Albumin 20|DRUG: 0.9 % Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tailored Prednisone Reduction in Preventing Hyperglycemia in Participants With B-Cell Non-Hodgkin Lymphoma Receiving Combination Chemotherapy Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Non-Hodgkin Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Prednisone|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donor T Cells in Treating Patients With High-Risk Hematologic Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant
Status: TERMINATED
Conditions: Graft Versus Host Disease|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: CD4+CD25+ regulatory T cells|PROCEDURE: allogeneic hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: OTHER: Normobaric hypoxia (FiO2 15%) under Sildenafil|OTHER: Normobaric hypoxia (FiO2 15%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Load & Resistance Training on Endothelial Function & Insulin Sensitivity
Status: COMPLETED
Conditions: 160 Participants Aged 18-35 Years and Obese (BMI ≥30) Open to Men and Women of All Ethnicity
Interventions: OTHER: Glycemic Load|OTHER: Resistance Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Practice vs Strength Training on Pain, Kinesiophobia and Function Among Sprinters
Status: RECRUITING
Conditions: Resistance Training|Patellofemoral Pain Syndrome|Kinesiophobia|Sprinters
Interventions: OTHER: Strength Training|OTHER: Mindfulness Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: SHR-1210 Alone or in Combination With Decitabine in Relapsed or Refractory Hodgkin Lymphoma
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: SHR-1210|DRUG: Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fixed vs. Tailored Intensity tDCS for Attention Deficit After TBI
Status: COMPLETED
Conditions: Traumatic Brain Injury|Attention Deficit|Cognitive Impairment
Interventions: DEVICE: transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality and Independence of Gait Classification Scale for DMD (QIGS-DMD)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy|Gait Disorders in Children
Interventions: DIAGNOSTIC_TEST: Quality and Independence of Gait Classification Scale for Duchenne Muscular Dystrophy (QIGS-DMD)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Magnetic Imaging Colonoscopy Applied to Beginner Endoscopists
Status: RECRUITING
Conditions: Colonic Neoplasms
Interventions: DEVICE: ScopeGuide Navigated Colonoscope|DEVICE: Navigation screen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility and Metabolic Effects of a 5:2 Fasting Intervention in Women With Breast Cancer During Radiotherapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: Curative radiotherapy|BEHAVIORAL: 5:2 intermittent fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intra-surgical Evaluation of CATS Tonometer Prism and Abbott Medical Optics Versus Alcon Phacoemulsification Machines
Status: COMPLETED
Conditions: Cataract Surgery
Interventions: DEVICE: Alcon phacoemulsification equipment|DEVICE: AMO phacoemulsification equipment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mucinex® ER 600 mg Bi-layer Tablet Versus Guaifenesin Immediate Release (IR) 200 mg q4h
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Mucinex®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study of Changing Exercise and Physical Activity Behavior in Asthma Patients
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Group 1|BEHAVIORAL: Group 2|BEHAVIORAL: Group 3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Gemcitabine, Carboplatin, and Lenalidomide for Treatment of Advanced/Metastatic Urothelial Cancer and Other Solid Tumors
Status: COMPLETED
Conditions: Urethral Neoplasms|Neoplasms, Urethral|Cancer of the Urethra|Urethral Cancer
Interventions: DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Placebo-Controlled Phase II Study of Continuous Maintenance Treatment With BIBF 1120 Following Chemotherapy in Patients With Relapsed Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms
Interventions: DRUG: BIBF1120|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Formulation and Clinical Evaluation of Ethosomal and Liposomal Preparations of Anthralin in Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: ethosomal preparation of anthralin|DRUG: liposomal preparation of anthralin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Community Based Group Psychoeducation for Relatives of Individuals With Mental Illness
Status: RECRUITING
Conditions: Caregiver Burden|Caregiver Burnout|Well-Being, Psychological|Coping Strategies|Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: The intervention is community based group psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety, Efficacy, and Pharmacokinetics Study of Tarceva to Treat Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Erlotinib (aka Tarceva or OSI-774)|DRUG: Bevacizumab (aka Avastin or Rhu MAb VEGF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition Intervention to Address Anemia Among Adolescent Girls in Liberia
Status: WITHDRAWN
Conditions: Nutritional Anemia|Nutritional Deficiency|Iron Deficiency Anemia Treatment|Folic Acid Deficiency Anemia, Dietary|Adolescent Development|Knowledge, Attitudes, Practice|Food Habits
Interventions: DIETARY_SUPPLEMENT: Iron and folic acid (IFA) supplementation|BEHAVIORAL: Targeted nutrition education|DRUG: Mebendazole Pill|OTHER: Standard nutrition services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adipose Tissue-derived Mesenchymal Stem Cell (AD-MSC) Therapy for the Treatment of Sexual Function Impairment in Female
Status: RECRUITING
Conditions: Sexual Dysfunction Female
Interventions: BIOLOGICAL: Autologous adipose-derived mesenchymal stem cell administration for female with sexual functional deficiency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SheppHeartCABG - Phase One Rehabilitation After Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Ischaemic Heart Disease
Interventions: OTHER: Comprehensive phase one rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of a Multicomponent Exercise Intervention on Physical and Cognitive Function of Older Adults With Dementia
Status: UNKNOWN
Conditions: Dementia|Alzheimer Disease|Vascular Dementia|Neurocognitive Disorders
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CPVI Alone Versus. CPVI Plus Electrophysiological Substrate Ablation in the LA During SR for the Treatment of Non-PAF
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: CPVI|PROCEDURE: STABLE-SR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Basket and Balloon in the Removal of Pancreatic Duct Stones in Chronic Pancreatitis Under ERCP
Status: ENROLLING_BY_INVITATION
Conditions: Pancreatitis, Chronic|Pancreatic Duct Stone
Interventions: DEVICE: Basket group|DEVICE: Balloon group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Use of a Graded Infusion of Intravenous Glucose in the Assessment of Insulin Secretion Rates (MK-0000-078)
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: Comparator: graded infusion of intravenous glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Preventive Treatment (IPTi) for the Prevention of Malaria and Anaemia in PNG Infants
Status: COMPLETED
Conditions: Malaria|Anemia
Interventions: DRUG: Amodiaquine/sulphadoxine-pyrimethamine, Artesunate/sulphadoxine-pyrimethamine or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PROACTIVE Study Evaluation of the Impact of a Multidimensional Geriatric Intervention Program
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Arm A: adapted physical activity + enhanced geriatric follow-up|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile - Bearing Knee Study
Status: COMPLETED
Conditions: Inflammatory Tissue Disorder|Osteoarthritis|Avascular Necrosis|Post-traumatic Arthritis|Secondary Arthritis
Interventions: DEVICE: Encore Mobile-Bearing Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in Preparation for a Prospective Cohort Study of Naturally-Acquired Malaria Immunity
Status: COMPLETED
Conditions: Malaria, Falciparum|Plasmodium Falciparum
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 3 Study to Evaluate the Safety and Efficacy of Saizen® in Children With Idiopathic Short Stature (ISS)
Status: COMPLETED
Conditions: Idiopathic Short Stature
Interventions: DRUG: Saizen®|DRUG: Saizen®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tesomet With Open-label Extension in Subjects With Prader-Willi Syndrome
Status: WITHDRAWN
Conditions: Prader-Willi Syndrome
Interventions: OTHER: Placebo|DRUG: Tesomet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TriRec - Trileaflet Reconstruction of the Aortic Valve With Autologous Pericardium
Status: RECRUITING
Conditions: Alternative Surgical Treatment for Aortic Valve Disease
Interventions: OTHER: TriRec|OTHER: Aortic valve replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenofovir Levels Following Local Application of Tenofovir Reduced-Glycerin 1% Gel
Status: COMPLETED
Conditions: HIV Prevention
Interventions: DRUG: Once Daily Application of TFV RG 1% Gel - Vaginal|DRUG: Once Daily Application of TFV RG 1% gel - Rectal|DRUG: Once Daily Application of TFV RG 1% gel - Rectal|DRUG: Once Daily Application of TFV RG 1% Gel - Vaginal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Rapid Normalization of Vitamin D in Critically Ill Children: A Phase II Dose Evaluation Randomized Controlled Trial
Status: COMPLETED
Conditions: Hypovitaminosis D
Interventions: DRUG: Vitamin D3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Ceftaroline fosamil and NXL104 (q8h)|DRUG: Ceftaroline fosamil and NXL104 (q12h)|DRUG: Doripenem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers
Status: COMPLETED
Conditions: Healthy Volunteers (Meningococcal Infection)
Interventions: BIOLOGICAL: Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid Conjugate vaccine (MenACYW Conjugate vaccine)|BIOLOGICAL: Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine (MENVEO®)|BIOLOGICAL: Diphtheria, Tetanus, Acellular Pertussis, Poliovirus and Haemophilus b Vaccine|BIOLOGICAL: Pneumococcal 13-valent Conjugate Vaccine|BIOLOGICAL: Rotavirus Vaccine|BIOLOGICAL: Hepatitis B Vaccine|BIOLOGICAL: Measles, Mumps, and Rubella Virus Vaccine|BIOLOGICAL: Varicella Virus Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION