pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Beta Blockers Versus Variceal Band Ligation and Beta Blockers for Primary Prophylaxis of Variceal Bleeding
Status: TERMINATED
Conditions: Esophageal Varices
Interventions: PROCEDURE: endoscopic variceal band ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SB-705498 Dental Pain Study After Tooth Extraction
Status: COMPLETED
Conditions: Toothache
Interventions: DRUG: SB705498 400 mg|DRUG: SB705498 1000 mg|DRUG: Placebo|DRUG: Co-Codamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Safety and PK Profile of HRS4800 in Healthy Subjects
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: HRS4800 tablets|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Assisted Rehabilitation for Balance and Gait in Orthopedic Patients.
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Osteoarthritis, Hip|Gait Disorders in Old Age|Balance; Distorted
Interventions: DEVICE: Technological Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nociception-directed Erector Muscle Spinae Plane Block in Open Heart Surgery
Status: COMPLETED
Conditions: Regional Anesthesia|Heart Surgery
Interventions: DRUG: General anesthetic|DRUG: Ropivacaine 0.5% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intralesional Acyclovir Versus Cryotherapy in the Treatment of Plantar Warts. A Randomized Controlled Trial.
Status: RECRUITING
Conditions: Plantar Wart
Interventions: DRUG: Intralesional Acyclovir|DEVICE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study
Status: COMPLETED
Conditions: Provoked, Localized Vulvodynia|Provoked Vestibulodynia|Vulvar Vestibulitis|Vulvodynia
Interventions: PROCEDURE: Classical Acupuncture|PROCEDURE: Non-classical acupuncture|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Banked Cord Blood or Bone Marrow Stem Cells in Children With Cerebral Palsy (CP).
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: BIOLOGICAL: umbilical cord blood (hUCB) cells|DRUG: Saline Infusion (Placebo)|BIOLOGICAL: bone marrow derived mononuclear cells (BMMNCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Asthma in High Risk Kids
Status: ACTIVE_NOT_RECRUITING
Conditions: Asthma
Interventions: DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neural Plasticity and Motor Recovery After Early and Intensive Upper Extremity Motor Training in People With c-SCI
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: experimental group: intensive motor training|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Transcranial Direct Current Stimulation in Treatment of Cognitive Deficits in Early Stages of Psychosis
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Molecular-Guided Surgery for Pancreatic and GI Neuroendocrine Cancers
Status: WITHDRAWN
Conditions: Neuroendocrine Carcinoma of Pancreas|Carcinoid
Interventions: DRUG: Gallium Dotatate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Italian Multicenter Database for Open Conversions After EVAR
Status: NOT_YET_RECRUITING
Conditions: Abdominal Aortic Aneurysm|Abdominal Aortic Aneurysm Enlargement
Interventions: PROCEDURE: Open Conversion after EVAR|PROCEDURE: SemiConversion after EVAR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass
Status: COMPLETED
Conditions: Pre-diabetes|Type 2 Diabetes
Interventions: DRUG: Exenatide|DRUG: Sitagliptin|DRUG: Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LEE011 With Fulvestrant and BYL719 or BKM120 in Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: LEE011|DRUG: BYL719|DRUG: fulvestrant|DRUG: BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Application of Novel Oncolytic Virus in Late Stage Solid Tumors
Status: RECRUITING
Conditions: Malignant Tumor
Interventions: DRUG: Oncolytic Virus SDJ001|DRUG: Oncolytic Virus YD06-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial
Status: UNKNOWN
Conditions: Stroke Hemorrhagic|Intracerebral Haemorrhage
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of the NJSPB SCF Project for Opioid-Involved High-Risk Parolees
Status: UNKNOWN
Conditions: Substance Abuse|Criminal Behavior
Interventions: BEHAVIORAL: SCF Supervision|BEHAVIORAL: Parole-as-Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exercises With Elastic Bands and Stability in Proprioception and Strength in Female Athletes of Taekwondo
Status: WITHDRAWN
Conditions: Proprioceptive Disorders
Interventions: OTHER: Strength and proprioception exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Safety Evaluation of Silver Alginate (Algidex™) Dressing in Very Low Birth Weight (VLBW) Infants
Status: COMPLETED
Conditions: Prematurity|Very Low Birth Weight
Interventions: DEVICE: Silver Alginate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Exenatide-LAR and Dapagliflozin in Overweight/Obese, Insulin Treated Patients With Type 2 Diabetes
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Exenatide-LAR plus Dapagliflozin placebo|DRUG: Exenatide-LAR plus Dapagliflozin|DRUG: Insulin Titration|BEHAVIORAL: Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Pharmacokinetics and Pharmacodynamics of CHF5074 in Healthy Young Male Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: CHF5074 1x|DRUG: CHF5074 2x|DRUG: CHF5074 3x|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion
Status: ACTIVE_NOT_RECRUITING
Conditions: Calcium Oxalate Urolithiasis
Interventions: OTHER: Low Oxalate Diet|OTHER: Moderately high oxalate/low calcium diet|OTHER: Oxalobacter formigenes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zanubrutinib Followed Zanubrutinib Plus FCR / BR in Newly Diagnosed Symptomatic CLL/SLL
Status: NOT_YET_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Newly Diagnosed
Interventions: DRUG: Zanubrutinib, Fludarabine, cyclophosphamide and rituximab|DRUG: Zanubrutinib, bendamustine, rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pyronaridine Artesunate (3:1) Versus Coartem® in P Falciparum Malaria Patients
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Pyronaridine artesunate|DRUG: Coartem® (artemether lumefantrine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Real World Effectiveness of SQ Sublingual Immunotherapy (SLIT)-Tablets vs. Controls in Allergic Rhinitis and Asthma
Status: ACTIVE_NOT_RECRUITING
Conditions: Allergy|Allergic Rhinitis|Asthma
Interventions: DRUG: SQ SLIT-tablet
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Tolerance Study of Oral Doses of CT53518 to Treat Patients With Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: CT53518
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fetal Cystoscopy for Lower Urinary Tract Obstruction
Status: TERMINATED
Conditions: Urethral Obstruction
Interventions: PROCEDURE: Fetal Cystoscopy|PROCEDURE: Fetal vesicoamniotic shunt
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Amoxicillin 400 mg/Clavulanic Acid 57 mg Chewable Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Amoxicillin 400mg + clovalunic acid 57.5mg chewable tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: SBRT + Atezolizumab + Bevacizumab in Resectable HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Resectable Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab|DRUG: Bevacizumab|RADIATION: Stereotactic Beam Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence Of a Natural Anti-Inflammatory Product On Levels Of Inflammatory Markers In Cases With Osteoarthritis Of Knee
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: DIETARY_SUPPLEMENT: PRN Joint Health Formula|DIETARY_SUPPLEMENT: placebo|DIETARY_SUPPLEMENT: PRN Flex Omega Benefits® combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pembrolizumab With Chemotherapy in Front Line Advanced Ovarian, Primary Peritoneal and Fallopian Tube Cancer
Status: RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow up Study to Assess Long Term Safety and Outcomes in Infants and Children Born to Mothers Participating in Retosiban Treatment Studies
Status: COMPLETED
Conditions: Obstetric Labour, Premature
Interventions: DRUG: Retosiban|DRUG: Atosiban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine in Coronary Artery Bypass Graft (CABG)
Status: COMPLETED
Conditions: Elective Coronary Artery Bypass Graft Surgery
Interventions: DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: REpositionable Versus BallOOn-expandable Prosthesis for Trans-catheter Aortic Valve Implantation
Status: COMPLETED
Conditions: Aortic Valve Disease
Interventions: DEVICE: repositionable valve prosthesis|DEVICE: balloon-expandable valve prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase Ⅱa Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of Improve Other Aspects of Healthy Adult With Influenza Fever
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: Baicalein Tablets 400mg|DRUG: Baicalein Tablets 600mg|DRUG: blank control 0mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVIDOM: Longterm Morbidity of SARS-CoV-2 Infection and COVID-19 Disease - Consequences for Health Status and Quality of Life
Status: RECRUITING
Conditions: COVID-19
Interventions: OTHER: Observation of different courses of SARS-CoV-2 infection in different phases (acute vs. post-acute) and settings
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Covered vs Uncovered Metal Stents for Palliative Biliary Decompression in Inoperable Malignant Distal Bile Duct Obstruction
Status: COMPLETED
Conditions: Distal Bile Duct Obstruction
Interventions: DEVICE: Covered Self-expanding metal biliary stents (C-SEMS)|DEVICE: Uncovered Self-expanding metal biliary stents (U-SEMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Belimumab In Early Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus Erythematosus, Systemic
Interventions: BIOLOGICAL: Belimumab|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Combination With Irinotecan- Erbitux
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer (MCRC)
Interventions: DRUG: Cetuximab|DRUG: Irinotecan|DRUG: Brivanib|DRUG: Brivanib|DRUG: Brivanib Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Infliximab on the Efficacy of Peg-Intron/Ribavirin in Patients With Hepatitis C (Study P04257AM4)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Induction dose of (a) infliximab followed by combination of (b) pegylated interferon alfa-2b and (c) ribavirin|DRUG: Combination of (a) pegylated interferon alfa-2b and (b) ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of CMP-001 in Combination With Pembrolizumab or as a Monotherapy
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: CMP-001|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Human Sperm Survival Assay (HSSA) as an Internal Quality Control for the IVF Consumables (REPROTOX 2)
Status: UNKNOWN
Conditions: Human Sperm Survival Assay|Embryotoxicity|in Vitro Fertilization
Interventions: BIOLOGICAL: HSSA test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Using Virtual Reality Glasses on Pain During Fistula Cannulation in Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis Patients
Interventions: OTHER: distraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies
Status: ENROLLING_BY_INVITATION
Conditions: Pre-Eclampsia
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|DIETARY_SUPPLEMENT: Placebo juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Colonic Stenting With Elective Surgery Versus Emergency Surgery in the Management of Acute Malignant Colonic Obstruction
Status: UNKNOWN
Conditions: Acute Malignant Colonic Obstruction|Colorectal Cancer|Colonic Obstruction
Interventions: PROCEDURE: Colonic Stenting with Elective Surgery|PROCEDURE: Emergency Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Tolerability of Anacetrapib Added to Ongoing Lipid-Lowering Therapy in Adult Participants With Homozygous Familial Hypercholesterolemia (HoFH) (MK-0859-042)
Status: TERMINATED
Conditions: Hyperlipoproteinemia Type II|Homozygous Familial Hypercholesterolemia
Interventions: DRUG: Anacetrapib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TARCEVA (Erlotinib) in Combination With Chemoradiation in Patients With Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: Erlotinib|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research of CAR T Cells Targeting HER2 Positive Cancer
Status: WITHDRAWN
Conditions: Breast Cancer|Ovarian Cancer|Lung Cancer|Gastric Cancer|Colorectal Cancer|Glioma|Pancreatic Cancer
Interventions: BIOLOGICAL: Anti-HER2 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)
Status: RECRUITING
Conditions: Stroke, Acute
Interventions: DEVICE: Direct to Angio Suite (DTAS) Philips' CBCT triage|PROCEDURE: Conventional CT/MR triage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Effect and Tolerance of the Association of Baricitinib and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Baricitinib Oral Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Theophylline in Treating Cancer Patients With Shortness of Breath
Status: COMPLETED
Conditions: Pulmonary Complications|Quality of Life|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: theophylline|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma
Status: COMPLETED
Conditions: Scleroderma
Interventions: DRUG: atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nevirapine Plus Zidovudine to Prevent Perinatal HIV in Thailand
Status: COMPLETED
Conditions: HIV Infections|Pregnancy
Interventions: DRUG: Single dose nevirapine to the mother and to the child|DRUG: Single dose nevirapine to the mother and placebo to the child|DRUG: Single dose placebo to the mother and to the child
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck
Status: RECRUITING
Conditions: Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Stage 0 Hypopharyngeal Cancer|Stage 0 Laryngeal Cancer|Stage 0 Lip and Oral Cavity Cancer|Stage I Adenoid Cystic Carcinoma of the Oral Cavity|Stage I Mucoepidermoid Carcinoma of the Oral Cavity|Stage I Squamous Cell Carcinoma of the Hypopharynx|Stage I Squamous Cell Carcinoma of the Larynx|Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage I Verrucous Carcinoma of the Larynx|Stage I Verrucous Carcinoma of the Oral Cavity|Stage II Adenoid Cystic Carcinoma of the Oral Cavity|Stage II Mucoepidermoid Carcinoma of the Oral Cavity|Stage II Squamous Cell Carcinoma of the Hypopharynx|Stage II Squamous Cell Carcinoma of the Larynx|Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage II Verrucous Carcinoma of the Larynx|Stage II Verrucous Carcinoma of the Oral Cavity|Stage III Adenoid Cystic Carcinoma of the Oral Cavity|Stage III Mucoepidermoid Carcinoma of the Oral Cavity|Stage III Squamous Cell Carcinoma of the Hypopharynx|Stage III Squamous Cell Carcinoma of the Larynx|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Verrucous Carcinoma of the Larynx|Stage III Verrucous Carcinoma of the Oral Cavity|Stage IV Squamous Cell Carcinoma of the Hypopharynx|Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Larynx|Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVA Verrucous Carcinoma of the Larynx|Stage IVA Verrucous Carcinoma of the Oral Cavity|Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Larynx|Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVB Verrucous Carcinoma of the Larynx|Stage IVB Verrucous Carcinoma of the Oral Cavity|Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Larynx|Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage IVC Verrucous Carcinoma of the Larynx|Stage IVC Verrucous Carcinoma of the Oral Cavity|Tongue Cancer
Interventions: PROCEDURE: transoral robotic surgery|PROCEDURE: quality of life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Retrospective Study to Evaluate the Safety and Efficacy of a Nucleoside-Sparing Regimen of Darunavir, Ritonavir, and Dolutegravir
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: Darunavir 800 MG, Norvir 100 MG, Dolutegravir 50 MG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of a Silver Containing Dressing (Acticoat) on Wound Complication Rates Post Elective Cesarean Section
Status: COMPLETED
Conditions: Surgical Wound Infection
Interventions: DEVICE: Acticoat PostOp|DEVICE: OpSite PostOp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of the Therapeutic Toys During Intravenous Canula Insertion
Status: COMPLETED
Conditions: Pain, Acute|Comfort
Interventions: DEVICE: therapeutic toy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus
Status: COMPLETED
Conditions: Lichen Sclerosus
Interventions: DEVICE: FxCO2 Laser|DEVICE: Sham Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ciprofibrate and Pre-diabetes
Status: COMPLETED
Conditions: Myocardial Insulin Sensitivity|Impaired Glucose Metabolism|Diastolic Dysfunction
Interventions: DRUG: Ciprofibrate 100Mg Tablet|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Seroprevalence of SARS-CoV-2 in Strasbourg University Hospital, Strasbourg, France (COVID-19)
Status: COMPLETED
Conditions: SARS-CoV-2 Serological Status|SARS-CoV-2 Seroprevalence
Interventions: DIAGNOSTIC_TEST: Blood sample for serological test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia
Status: COMPLETED
Conditions: Hypercholesterolemia|Mixed Dyslipidemia|Type 2 Diabetes
Interventions: BIOLOGICAL: Evolocumab|DRUG: Placebo to Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxygen Consumption and Sevoflurane Uptake Based on Physiological Dead Space Estimation
Status: RECRUITING
Conditions: Oxygen Consumption|Sevoflurane|Anesthetics, Inhalation|Surgery
Interventions: PROCEDURE: VO2 estimation|PROCEDURE: SEVOup estimation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulfate for TAP Analgesia During Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Magnesium Sulfate|DRUG: bupevecaine|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Pasireotide LAR in Patients With Castration Resistant Prostate Cancer
Status: COMPLETED
Conditions: Castration Resistant Prostate Cancer
Interventions: DRUG: SOM230
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Arabic Gamified Mobile Application on Diabetes Control in Egyptian Pediatric Patients With Type 1 Diabetes.
Status: NOT_YET_RECRUITING
Conditions: Diabetic Pediatric Patients With Type 1 Diabetes
Interventions: DEVICE: educational game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma (CheckMate 025)
Status: COMPLETED
Conditions: Advanced or Metastatic (Medically or Surgically Unresectable) Clear-cell Renal Cell Carcinoma
Interventions: BIOLOGICAL: Nivolumab|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 Signaling in Truncally Vagotomized Subjects
Status: UNKNOWN
Conditions: Physiology
Interventions: DRUG: Tablet Sitagliptin 100mg (evening before and morning of experiments)|OTHER: Intestinal Fructose administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer
Status: COMPLETED
Conditions: Adenomatous Polyp|Colorectal Carcinoma
Interventions: DRUG: macrogol 3350-based oral osmotic laxative|OTHER: Placebo|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Controlled-Study of Fenofibrate 145 mg and Ezetimibe 10 mg in Type IIb Dyslipidemic Patients With Features of the Metabolic Syndrome
Status: COMPLETED
Conditions: Hyperlipidemia Combined
Interventions: DRUG: Combination of 145 mg fenofibrate and 10 mg ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life of Patients and Theirs Parents With Inherited Metabolic Diseases With Restricted Diet
Status: UNKNOWN
Conditions: Inherited Metabolic Diseases Requiring Restrictive and Specific Diet
Interventions: BEHAVIORAL: data assessment of the state of health and quality of life of patients and their families
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Improving Beta-2 Adrenergic Signaling in Alzheimer's Disease
Status: WITHDRAWN
Conditions: Alzheimer's Disease|Cognitive Dysfunction
Interventions: DRUG: Formoterol A|OTHER: Formoterol B (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib in Combination With Ibrutinib in Ibrutinib Relapsed Mantle Cell Lymphoma
Status: WITHDRAWN
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Bortezomib|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability and Bioavailability of Utidelone Capsule in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: Utidelone Capsule (Part 1)|DRUG: Drug A Utidelone Capsule (Part 2: Group A-B)|DRUG: Drug A Utidelone Capsule (Part 2: Group B-A)|DRUG: Drug B Utidelone Injection (Part 2: Group A-B)|DRUG: Drug B Utidelone Injection (Part 2: Group B-A)|DRUG: Capecitabine|DRUG: Utidelone Capsule (Part 3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Augmenting Referral Pathway to Improve Uptake of Retinal Services by Diabetic Patients
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: BEHAVIORAL: Pre-post educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Primary & Booster Study in Infants to Demonstrate Non-inferiority, Persistence & Immunogenicity of Hib-MenC Vaccine
Status: COMPLETED
Conditions: Neisseria Meningitidis|Haemophilus Influenzae Type b
Interventions: BIOLOGICAL: Haemophilus influenzae type b- and meningococcal serogroup C (vaccine)|BIOLOGICAL: Infanrix Penta|BIOLOGICAL: Infanrix hexa|BIOLOGICAL: Neis-Vac-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Contact Phase Activation During Hemodialysis
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: PMMA (BKU)|DEVICE: PS (Phylter)|DEVICE: AN69ST (Evodial)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Wakaya: Rising Up for Choctaw Youth Health
Status: RECRUITING
Conditions: Obesity, Adolescent|Healthy Nutrition|Sedentary Behavior|Drug Abuse
Interventions: BEHAVIORAL: Wakaya: Rising Up for Choctaw Youth Curriculum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of CC-486 in Subjects With Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Oral Azacitidine|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melphalan Hydrochloride in Treating Participants With Newly-Diagnosed Multiple Myeloma Undergoing Donor Stem Cell Transplantation
Status: COMPLETED
Conditions: Plasma Cell Myeloma
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|BIOLOGICAL: Filgrastim-sndz|DRUG: Melphalan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Benign Paroxysmal Positional Vertigo in Older Adults
Status: UNKNOWN
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: OTHER: Particle Repositioning Maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of Quality of Life Assessment After Laparoscopic TAPP and TEP Surgery of Inguinal Hernias Using EuraHS of Life Score and Carolinas Comfort Scale™
Status: COMPLETED
Conditions: Primary Unilateral Inguinal Hernias
Interventions: PROCEDURE: TAPP repair for inguinal hernias|PROCEDURE: TEP repair for inguinal hernia|OTHER: EuraHS-QoL questionnaire|OTHER: Carolina Comfort Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prophylactic Octreotide to Prevent Post Duodenal EMR and Ampullectomy Bleeding
Status: TERMINATED
Conditions: Adenoma
Interventions: DRUG: octreotide|OTHER: No Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Vergence Exercises for Patients With Convergence Insufficiency After Concussion.
Status: RECRUITING
Conditions: Concussion, Mild|Convergence Insufficiency
Interventions: OTHER: Vergence exercises (Orthoptic exercises)|GENETIC: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Silicone Hydrogel Daily Wear Contact Lenses for Up to One (1) Month of Daily Wear
Status: COMPLETED
Conditions: Myopia|Hyperopia|Astigmatism
Interventions: DEVICE: Invigor A (test)|DEVICE: Invigor B (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiofrequency Ablation of Atrial Fibrillation Under Totally Thoracoscope
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: epicardial radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Corticosteroid Regimens for Post COVID-19 Diffuse Lung Disease
Status: COMPLETED
Conditions: Post COVID-19 Diffuse Lung Disease
Interventions: DRUG: Medium dose prednisolone|DRUG: Low dose prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FDG and FDOPA PET Demonstration of Functional Brain Abnormalities
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: PROCEDURE: Positron Emission Tomography|PROCEDURE: Computed Tomography|PROCEDURE: Multiparametric Magnetic Resonance Imaging Scan|RADIATION: Fludeoxyglucose F-18|RADIATION: fluorine F 18 fluorodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase I Dose Escalation Study of the Safety and Pharmacokinetics of LAM-002A In Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin; Leukemia, Chronic Lymphocytic
Interventions: DRUG: LAM-002A|DRUG: Rituximab|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Composition on the Oral Microbiome, pH, Nitrite/Nitrate Ratio, Elastases and Inflammation in Oral Dysbiosis
Status: COMPLETED
Conditions: Oral Dysbiosis
Interventions: DRUG: Test composition Saliactive® (olive product, betaine and xylitol)|DRUG: Placebo|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Counseling on the Continuation Rates and Compliance for Newly Prescribed Oral Contraceptives (Yasmin® or Any Other Oral Contraceptives (OC)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: EE30/DRSP (Yasmin, BAY86-5131)|DRUG: Any other OC
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Insulin Detemir Plus Insulin Aspart Against Insulin Glargine Plus Insulin Aspart in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin glargine|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of ETC-1002 in Participants With Statin Intolerance
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ETC-1002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Potassium Bicarbonate Improve the Effect of Dietary Protein on Bone and Muscle?
Status: COMPLETED
Conditions: Osteoporosis|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: potassium bicarbonate|DIETARY_SUPPLEMENT: Placebo (microcrystalline cellulose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of the Third Dose Immunization Schedule of COVID-19 Inactivated Vaccine, (Vero Cells) in Adults Aged 18 Years and Above (6 Months After Two Doses)
Status: UNKNOWN
Conditions: SARS-CoV-2 Infection
Interventions: BIOLOGICAL: SARS-CoV-2 Vaccine, Inactivated (Vero Cell)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Long Term Comparison of Ultrasonic and Hand Instrumentation in the Maintenance of Peri-implant Tissues: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Determination of Clinical Effects|Presence of Inflammatory Cytokines|Patients Perception of Discomfort|Titanium Scalers|Ultrasonics
Interventions: PROCEDURE: Peri-implant maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance
Status: RECRUITING
Conditions: Bacterial Meningitis|Augmented Renal Clearance
Interventions: DRUG: meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1 Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF-01913539] In Japanese And Western Healthy Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease|Huntington's Disease
Interventions: DRUG: Dimebon|DRUG: Dimebon|DRUG: Dimebon|DRUG: Dimebon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Expansion Modular Study To Explore the Safety, Tolerability, and Anti-tumor Activity of HER3- DXd Monotherapy and Combinations in Patients With Inoperable Advanced Breast Cancer (ABC) After Progression on T-DXd
Status: RECRUITING
Conditions: Breast Cancer Metastatic|HER2-positive Metastatic Breast Cancer|HER2 Low Breast Carcinoma|Advanced Breast Cancer
Interventions: DRUG: Patritumab deruxtecan|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacology Study of VP 20629 in Adults With Friedreich's Ataxia
Status: COMPLETED
Conditions: Friedreich's Ataxia
Interventions: DRUG: VP 20629|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mouth Rinses for Inactivation of COVID-19
Status: TERMINATED
Conditions: Covid19|Coronavirus Infection|SARS-CoV-2 Infection
Interventions: OTHER: 0.9% w/v NaCL Saline|DRUG: 1.5% w/v Hydrogen Peroxide|DRUG: 0.12% Chlorohexidine Gluconate|DRUG: 27% Ethanol plus essential oils|DRUG: 0.5% w/v Povidone-iodide|DRUG: 0.075% Cetylpyridinium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Affect of Incentive Strategy on the Adherence to Medication Among Patients With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Give incentives to patients based on their own HbA1c improvement|BEHAVIORAL: Give incentives to physician based on their patient's HbA1c improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients
Status: TERMINATED
Conditions: Amyloidosis; Systemic
Interventions: DRUG: Propylene Glycol-Free Melphalan Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guilingji Capsule for Mild-to-moderate Cognitive Impairment
Status: UNKNOWN
Conditions: Cognitive Dysfunction
Interventions: DRUG: Gulingji capsules|DRUG: Ginko Biloba Extract tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Endometrial Assessment of Women With Uterine Infection
Status: RECRUITING
Conditions: Infertility
Interventions: PROCEDURE: manipulation of endometrium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-arterial Hepatic Bevacizumab and Systemic Chemotherapy
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Bevacizumab|DRUG: Capecitabine|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab (AK104) With or Without CT as 2rd Line Treatment for ES-SCLC
Status: RECRUITING
Conditions: Immunotherapy|Second-line Treatment
Interventions: DRUG: Cadonilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Precise Therapy for Refractory HER2 Positive Advanced Breast Cancer
Status: UNKNOWN
Conditions: HER2+ Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Nab paclitaxel|DRUG: Pyrotinib|DRUG: Capecitabine|DRUG: T-DM1|DRUG: Everolimus|DRUG: CDK4/6 inhibitor|DRUG: AI|DRUG: Anti-PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
Status: COMPLETED
Conditions: Return of Motor and Sensory Blockade|Anesthesia, Spinal|Decrease Discharge Time Status Post Hemmoriodectomy
Interventions: DRUG: 1% chloroprocaine|DRUG: 0.75% bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Digestibility of Different Plant-based Proteins in Humans With Ileostomy
Status: RECRUITING
Conditions: Ileostomy - Stoma
Interventions: DIETARY_SUPPLEMENT: Oat Protein, low bioavailability|DIETARY_SUPPLEMENT: Oat Protein, high bioavailability|DIETARY_SUPPLEMENT: Pea Protein, low bioavailability|DIETARY_SUPPLEMENT: Pea Protein, high bioavailability|DIETARY_SUPPLEMENT: Protein-free meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG)
Status: RECRUITING
Conditions: Recurrent High-grade Glioma
Interventions: DRUG: Xevinapant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
Status: COMPLETED
Conditions: Sepsis
Interventions: DRUG: Hydrocortisone, Vitamin C, and Thiamine|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT