pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study Comparing Conventional and Fast Track Multi-Discipline Treatment Interventions for Colorectal Cancer
Status: COMPLETED
Conditions: Length of Stay|Complications|Adverse Drug Event|Quality of Life|Hospital Costs
Interventions: PROCEDURE: Laparoscopic Surgery for Colorectal Cancer|DRUG: XELOX Chemotherapy|DRUG: mFolfox6 chemotherapy|OTHER: Fast Track Perioperative Treatment|OTHER: Conventional Perioperative Treatment|PROCEDURE: Open Surgery for Colorectal Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Video-based Telemedicine to Reduce Hypoglycemia Fear in Parents of Young Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: REDCHiP|BEHAVIORAL: ATTN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Use of a Digital Health System of Pelvic Floor Exercise Program to Kegel Exercises in Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Mixed Urinary Incontinence
Interventions: DEVICE: Leva|DEVICE: PFDx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: GEM05 for Patients With Multiple Myeloma Under 65 Years
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: VBMCP/VBAD/Velcade|DRUG: Thalidomide/Dexamethasone|DRUG: Velcade/Thalidomide/Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Injection Optimization of Infraclavicular and Axillary Brachial Plexus Block
Status: COMPLETED
Conditions: Brachial Plexus Block
Interventions: OTHER: Infraclavicular brachial plexus block|OTHER: axillary brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Renal Oxygenation by NIRS in Pediatric Endourologic Stone Surgery
Status: COMPLETED
Conditions: Renal Stone|Kidney; Complications|Ureter Stone|Renal Oxygenation
Interventions: DEVICE: NIRS|OTHER: Taking a blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medical Stone Expulsive Therapy for Acutely Obstructed Ureteric Calculi
Status: NOT_YET_RECRUITING
Conditions: Ureteric Stone of Lower Third of Ureter
Interventions: DRUG: Tamsulosin Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiosurgery for the Treatment of Refractory Ventricular Extrasystoles and Tachycardias
Status: ACTIVE_NOT_RECRUITING
Conditions: Ventricular Tachycardia
Interventions: RADIATION: Cardiac Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Telemonitoring of Resting Spontaneous Breathing in Severe Asthma: a Pilot Study
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: anharmonic morphological analysis of the respiratory signals (AMARS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination of Chidamide and Fulvestrant for HR+/HER2- Breast Cancer That Has Failed Previous CDK4/6 i Adjuvant Therapy
Status: NOT_YET_RECRUITING
Conditions: Hormone Receptor-positive Advanced Breast Cancer
Interventions: DRUG: chidamide combined with fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess Safety and Efficacy of Agents Targeting DNA Damage Repair With Olaparib Versus Olaparib Monotherapy.
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: Olaparib Continuous (28-Day cycle) 300 mg BD.|DRUG: Ceralasertib 160 mg OD + olaparib continuous 300 mg BD (28-day cycle).|DRUG: Adavosertib 150 mg BD + olaparib 200 mg BD (21-day cycle).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Thalidomide in Treating Patients With Recurrent or Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: thalidomide|PROCEDURE: adjuvant therapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vonoprazan as First-line Treatment for Helicobacter Pylori Eradication
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Vonoprazan|DRUG: Esomeprazole|DRUG: Colloidal bismuth pectin|DRUG: Amoxicillin|DRUG: Furazolidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of SYR-619 in Treating Subjects With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: DRUG: SYR-619|DRUG: SYR-619|DRUG: SYR-619|DRUG: SYR-619|DRUG: Placebo|DRUG: Alogliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Prefabrication of Body Surface Tissues/ Organs(e.g. Joint)
Status: UNKNOWN
Conditions: Soft Tissue Infections|Intentional Self Harm by Other Specified Means
Interventions: PROCEDURE: tissue/ organ prefabrication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML).
Status: COMPLETED
Conditions: Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: Panobinostat (LBH589)|DRUG: 5-Azacytidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soluble Corn Fiber Effect on Bone Resorption in Post Menopausal Women
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DIETARY_SUPPLEMENT: 0 g SCF|DIETARY_SUPPLEMENT: 10g SCF|DIETARY_SUPPLEMENT: 20g SCF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Interfascial Injection Versus Subpectineal Injection on Ultrasound-guided Obturator Nerve Block
Status: COMPLETED
Conditions: Bladder Neoplasm
Interventions: PROCEDURE: Interfascial Injection|PROCEDURE: Subpectineal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Progesterone Amplifies Estrogen-stimulated Growth Hormone Secretion in Older Women
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: IM Saline Placebo (0.25 ml)|DRUG: IM Estradiol valerate (2.5 mg)|DRUG: IM Saline Placebo (0.5 ml)|DRUG: IM Estradiol valerate (5.0 mg)|DRUG: Oral Micronized Progesterone|DRUG: Oral Placebo|DRUG: Ghrelin (0.3 ug/kg)|DRUG: Medroxyprogesterone - Acetate|DRUG: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intensity-modulated Radiation Therapy Combined With Cisplatin or Nedaplatin Chemotherapy in Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cisplatin|DRUG: Nedaplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Added Value of Contrast Enhancement for Guiding EUS-FNA in Solid Pancreatic Masses
Status: COMPLETED
Conditions: Endoscopic Ultrasonography
Interventions: DIAGNOSTIC_TEST: Endosonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A 5-year Clinical Trial Assessing the Effects of a Surface Sealant on Composite Resin Class I Restorations
Status: COMPLETED
Conditions: Definitive Restorations, Longevity
Interventions: PROCEDURE: Surface sealant|PROCEDURE: No surface sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Lintuzumab-Ac225 in Patients With Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: Lintuzumab AC 225
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food, Activity and Behavior Study
Status: WITHDRAWN
Conditions: Obesity
Interventions: OTHER: DGA diet WL & exercise|OTHER: DGA diet WL & no exercise|OTHER: DGA diet WM & exercise|OTHER: DGA diet WM & no exercise|OTHER: Western diet WL & exercise|OTHER: Western diet WL & no exercise|OTHER: Western diet WM & exercise|OTHER: Western diet WM & no exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Impact of Frailty on Thrombosis of Elderly Patients With NVAF （FTE-NVAF）
Status: UNKNOWN
Conditions: Non-valvular Atrial Fibrillation, Elderly, Frailty, Thrombosis
Interventions: OTHER: Diagnostic Test: CHA2DS2-VASc, HAS-BLED and Fried Scale.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females
Status: RECRUITING
Conditions: Polycystic Ovary Syndrome|Infertility, Female
Interventions: DRUG: Alpha lipoic acid|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus|Chronic Periodontitis
Interventions: DRUG: SRP + Aloe|PROCEDURE: SRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma|Malignant Peripheral Nerve Sheath Tumors
Interventions: DRUG: PLX3397|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Relapse Prevention Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Eating Disorders|Anorexia Nervosa|Bulimia Nervosa|Anorexia Nervosa, Atypical|Other Specified Feeding or Eating Disorder
Interventions: BEHAVIORAL: Imaginal Exposure Condition|BEHAVIORAL: Writing and Thinking Condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Holmium: YAG Versus Cold Knife Internal Urethrotomy in Management of Short Urethral Strictures
Status: COMPLETED
Conditions: Urethral Stricture, Male
Interventions: PROCEDURE: visualized internal urethrotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic ADSCs and Platelet-Poor Plasma Fibrin Hydrogel to Treat the Patients With Burn Wounds (ADSCs-BWs)
Status: UNKNOWN
Conditions: Second- or Third-degree Burns
Interventions: BIOLOGICAL: ALLO-ASCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Prexasertib (LY2606368) in Platinum-Resistant or Refractory Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Prexasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DOV 21,947 in the Treatment of Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: DOV 21, 947|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Intervention and Fibroscan for Harmful Drinkers Presenting to the Emergency Department
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Use Disorder (AUD)
Interventions: DIAGNOSTIC_TEST: Fibroscan|BEHAVIORAL: Brief Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Using Xenograft Combined With Barrier Membrane to Improve the Formation of Deep Periodontal Pockets
Status: RECRUITING
Conditions: Periodontal Pocket|Periodontal Bone Loss|Impacted Third Molar Tooth
Interventions: PROCEDURE: site preservation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Induced and Controlled Dietary Ketosis as a Regulator of Obesity and Metabolic Syndrome Pathologies
Status: COMPLETED
Conditions: Metabolic Syndrome|Diabetes Mellitus, Type 2|Pre Diabetes
Interventions: BEHAVIORAL: Dietary Ketosis: Regulator of Obesity and Metabolic Syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of LP002 for the Treatment of Patients With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma
Status: UNKNOWN
Conditions: Primary Mediastinal Large B-Cell Lymphoma (PMBCL)
Interventions: DRUG: LP002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Micellar Curcumin and Metabolic Syndrome Biomarkers
Status: COMPLETED
Conditions: Metabolic Syndrome, Protection Against
Interventions: DIETARY_SUPPLEMENT: Micellar curcumin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atezolizumab, Guadecitabine, and CDX-1401 Vaccine in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Ovarian Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: DRUG: Atezolizumab|BIOLOGICAL: DEC-205/NY-ESO-1 Fusion Protein CDX-1401|DRUG: Guadecitabine|OTHER: Laboratory Biomarker Analysis|DRUG: Poly ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Vitamin D and Its Topical Analogues in Pathogenesis and Treatment of Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: DRUG: Vitamin D analog|DRUG: Adapalene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abatacept and Infliximab in Combination With Methotrexate in Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept (ABA) + Methotrexate (MTX), double-blind (DB)|DRUG: Infliximab (INF) + MTX, DB|DRUG: Placebo (PLA) + MTX, DB|DRUG: PLA + MTX switched to ABA+ MTX, DB|DRUG: ABA, open-label (OL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Mobile Lifestyle Intervention for Food and Exercise Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity|Type2 Diabetes
Interventions: BEHAVIORAL: Podcasts and tips of the day (within app)|BEHAVIORAL: mLIFE app (self-regulation features)|BEHAVIORAL: mLIFE app (social support features)|BEHAVIORAL: standard mLIFE app (social support features)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Supplement in Older Adults to Support Physical Fitness and Mental Well-being
Status: RECRUITING
Conditions: Osteo-arthritis
Interventions: DIETARY_SUPPLEMENT: Q-actin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of a Medicinal Cannabinoid Agonist on Responses to Food Images and Food Intake
Status: ACTIVE_NOT_RECRUITING
Conditions: Appetite Regulation
Interventions: DRUG: dronabinol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of ALZT-OP1a as Adjuvant Treatment in Subjects With Post-Ischemic Stroke Cognitive Impairment (PSCI)
Status: WITHDRAWN
Conditions: Ischemic Stroke|Post-stroke Cognitive Impairment
Interventions: DRUG: Cromolyn|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reverse Trendelenburg Position Versus Semi-recumbent Position in Obese Critically Ill Patients
Status: COMPLETED
Conditions: Ventilation and Oxygenation|Obese; Positioning|Critically Ill
Interventions: OTHER: Reverse Trendelenburg position|OTHER: Semi-recumbent position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Efficacy of a Food Supplement in Reducing Hair Loss in Male Subjects
Status: COMPLETED
Conditions: Hair Loss
Interventions: DIETARY_SUPPLEMENT: Alline proMEN|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Ovule With Flavonoid Tea Extract for the Correction of Imbalance in the Vaginal Environment
Status: COMPLETED
Conditions: Vaginosis, Bacterial|Vaginal Flora Imbalance
Interventions: DEVICE: Matuzalem ovule|DEVICE: Vehicle ovule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye
Status: COMPLETED
Conditions: Dry Eye Syndrome|Dry Eye
Interventions: DRUG: Thymosin beta 4|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin (DAPA) Effects in HFpEF
Status: COMPLETED
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Folic Acid Dosage and Malformations Reduction
Status: UNKNOWN
Conditions: Congenital Malformations
Interventions: DRUG: folic acid|DRUG: folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Continuous vs Intermittent Dabrafenib Plus Trametinib in BRAFV600 Mutant Stage 3 Unresectable or Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Elderly Subjects With Psychosis and Behavioral Disturbances Associated With Dementia of the Alzheimer's Type
Status: TERMINATED
Conditions: Psychosis and Behavioral Disturbances Associated With Dementia of the Alzheimer's Type
Interventions: DRUG: bifeprunox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial Comparing Non-ischemic to Ischemic Preservation in Adult Cardiac Transplantation
Status: COMPLETED
Conditions: Transplant; Failure, Heart
Interventions: OTHER: Non-ischemic preservation|OTHER: Ischemic cold static storage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of SRS on Hemiplegia in Stroke Survivors
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Sensory Threshold|BEHAVIORAL: Nine Hole Peg Test|BEHAVIORAL: Semmes Weinstein Monofilament Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Mild Stimulation Protocol Versus Microdose Gonadotropin-releasing Hormone Agonist Flare up Protocol in Poor Responders
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: clomiphene citrate|DRUG: buserelin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Twice or Once Daily DTG (50mg) in Children With HIV and TB
Status: RECRUITING
Conditions: Tuberculosis|Hiv
Interventions: DRUG: Dolutegravir 50 MG|DRUG: Dolutegravir 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Infliximab plus methotrexate|DRUG: Combination of DMARDs|DRUG: Methotrexate alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Transplant From Partially Matched Donors and Nonmyeloablative Conditioning for Blood Cancers (BMT CTN 0603)
Status: COMPLETED
Conditions: Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Leukemia, Myeloid, Acute|Burkitt Lymphoma|Lymphoma, B-Cell|Lymphoma, Follicular|Lymphoma, Large B-Cell, Diffuse
Interventions: BIOLOGICAL: Haploidentical Bone Marrow Transplantation|BIOLOGICAL: GVHD prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Instrument Based Fascial Abrasion Versus Myofascial Release Technique in Cervicogenic Headache Patients
Status: COMPLETED
Conditions: Cervicogenic Headache
Interventions: OTHER: Instrument based Fascial abrasion technique|OTHER: Myofascial release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease
Status: RECRUITING
Conditions: Chronic Obstructive Lung Disease|Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Thoracic resection surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months
Status: COMPLETED
Conditions: Hand, Foot and Mouth Disease|Herpangina|Other EV71-associated Diseases
Interventions: BIOLOGICAL: inactivated vaccine (Vero Cell) against EV71|BIOLOGICAL: 0/0.5ml placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Mindfulness and Cognitive Training Programs for Children With ADHD (the NeuroMind Study)
Status: RECRUITING
Conditions: ADHD
Interventions: BEHAVIORAL: TAU + UP4H|BEHAVIORAL: TAU + M4H|BEHAVIORAL: TAU + CT|OTHER: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients
Status: NOT_YET_RECRUITING
Conditions: Dyslipidemias|Statin Adverse Reaction|Cardiovascular Diseases|Lipid Metabolism Disorders
Interventions: DRUG: Lipid-lowering therapy combination with PCSK9 inhibitors, bempedoic acid and ezetimibe|DRUG: Lipid-lowering therapy combination with PCSK9 inhibitors and ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A New Micrografting Technique for Vitiligo
Status: TERMINATED
Conditions: Vitiligo
Interventions: DEVICE: Dermabrasion-Micrografting|PROCEDURE: Dermabrasion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantra Point-of-Care Hemostasis Monitoring
Status: NOT_YET_RECRUITING
Conditions: Bleeding|Hemostatic Disorder
Interventions: DEVICE: POC Quantra QPlus System|OTHER: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab Induction and Maintenance in Elderly Patients With Poor Risk CLL in the Context of Allogeneic Transplantation
Status: COMPLETED
Conditions: Chronic Lymphatic Leukemia
Interventions: DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Inflammatory Effects of 0.045% Tazarotene/0.01% Halobetasol Lotion in Psoriasis
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: 0.01% Halobetasol|DRUG: 0.045% Tazarotene|DRUG: 0.05% Clobetasol Propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combinatorial Pharmacogenomics Testing in Treatment-Naïve Major Depressive Disorder
Status: TERMINATED
Conditions: Major Depressive Disorder|Depression|Depressive Disorder|Depressive Episode|Depression, Unipolar
Interventions: OTHER: GeneSight Psychotropic test|DRUG: FDA-approved antidepressant or antipsychotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of CNCT19 Cell Injection in the Treatment of Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: RECRUITING
Conditions: Relapsed or Refractory Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: single dose of CNCT19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metacognitive Training and Insight in Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders
Interventions: OTHER: Metacognitive training (MCT)|OTHER: Support group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Remimazolam Versus Propopol Based Total Intravenous Anesthesia for Breast Surgery
Status: WITHDRAWN
Conditions: Hypotension
Interventions: DRUG: Remimazolam|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Orotracheal Intubation Using Flexible Fibro Bronchoscope With vs Without Supraglottic Device
Status: COMPLETED
Conditions: Intubation;Difficult
Interventions: DEVICE: Fiberoptic intubation with laryngeal mask AuraGain|DEVICE: Fiberoptic intubation without laryngeal mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Oral Doses of SY-009 in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: SY-009
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Electromagnetic Field Treatment for Painful Periods
Status: UNKNOWN
Conditions: Dysmenorrhea
Interventions: DEVICE: Allay|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparisons of Two Different Type Heater in Different Inhalation Anesthesia in Terms of Prevention of Hypothermia
Status: RECRUITING
Conditions: Anesthesia|Hypothermia|Heat
Interventions: DEVICE: COVIDIEN WarmTouch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adding Magnesium Sulfate to Bupivacaine for Ilioinguinal and Iliohypogastric Nerve Block
Status: COMPLETED
Conditions: Magnesium Sulfate Causing Adverse Effects in Therapeutic Use
Interventions: OTHER: normal saline|DRUG: MgSo4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Immunotherapy Combined With the Anti-GDF-15 Antibody Visugromab to Treat Muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Bladder Cancer|Adult Solid Tumor
Interventions: DRUG: Nivolumab|DRUG: Visugromab (CTL-002)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Neoplasms|Breast Neoplasms
Interventions: DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Prebiotic, Probiotic and Synbiotic on the Gut Microbiota and Immune Response of Older Volunteers (GOS)
Status: COMPLETED
Conditions: Gut Microbiota|Immune Function
Interventions: DIETARY_SUPPLEMENT: Synbiotic|DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Prebiotic|DIETARY_SUPPLEMENT: Probiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Intensity Resistance Training With and Without Blood Flow Restriction in ACL Reconstruction
Status: RECRUITING
Conditions: Resistance Training|Blood Flow Restriction Therapy|Anterior Cruciate Ligament Reconstruction|Volleyball
Interventions: OTHER: High intensity Traditional Resistance Traning without Blood Flow Restriction|OTHER: High intensity Traditional Resistance Traning with Blood Flow Restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: tocilizumab|DRUG: methotrexate|BIOLOGICAL: 23-Valent Pneumococcal Polysaccharide Vaccine|BIOLOGICAL: Tetanus Toxoid Adsorbed Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Ultrasound Guided Tissue Sampling (The SharkBITE Study)
Status: COMPLETED
Conditions: Pancreas Cancer|Pancreas Neoplasm, Benign|Chronic Pancreatitis|Pancreas Adenocarcinoma
Interventions: DEVICE: EUS-FNA needle (Beacon)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stem Cell Transplant in Sickle Cell Disease and Thalassemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease|Beta Thalassemia
Interventions: DRUG: Busulfan|DRUG: Fludarabine|DRUG: Alemtuzumab|PROCEDURE: Allogeneic stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cyclic Loading (Vibration) on Orthodontic Tooth Movement
Status: COMPLETED
Conditions: Malocclusion
Interventions: DEVICE: OrthoAccel Device|DEVICE: Sham Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Intravitreal Ranibizumab With or Without Micropulse Laser for the Treatment of DME
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Intravitreal Ranibizumab|PROCEDURE: Micropulse Laser|DRUG: Intravitreal Ranibizumab as needed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study to Evaluate the Renal (Kidney) Protective Effects of Losartan in Patients With Non-insulin Dependent Diabetes (0954-147)(COMPLETED)
Status: COMPLETED
Conditions: Type 2 Diabetes|Nephropathy
Interventions: DRUG: MK0954, losartan / Duration of Treatment: mean 3.4 years|DRUG: Placebo / Duration of Treatment: mean 3.4 years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lausanne Trialogue Paradigm - Brief: A Family Model for Child Mental Health in a Community Setting
Status: UNKNOWN
Conditions: Parent-Child Relations|Family Relations|Internet-Based Intervention|Mental Health Issue|Behavioral Problem
Interventions: BEHAVIORAL: Lausanne Trialogue Play Brief
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischaemic Conditioning for Fatigue After Stroke
Status: COMPLETED
Conditions: Stroke, Ischemic|Stroke Hemorrhagic|Fatigue
Interventions: PROCEDURE: Remote Ischaemic Conditioning|PROCEDURE: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liraglutide in Acute Minor Ischemic Stroke or High-risk Transient Ischemic Attack Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Ischemic Stroke|Transient Ischemic Attack|Type 2 Diabetes Mellitus
Interventions: DRUG: Liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TA(E)C-GP Versus A(E)C-T for the High Risk TNBC Patients and Validation of the mRNA-lncRNA Signature
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer|Breast Cancer
Interventions: DRUG: docetaxel|DRUG: doxorubicin or epirubicin|DRUG: cyclophosphamide|DRUG: gemcitabine|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduction in Cardiovascular Risk Factors and Visceral Adipose Tissue in Men: Separate Effects of Diet- and Exercise-Induced Weight Loss
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Diet Weight Loss|BEHAVIORAL: Exercise Weight Loss|BEHAVIORAL: Exercise Without Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Internet-delivered Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Status: RECRUITING
Conditions: CIPN - Chemotherapy-Induced Peripheral Neuropathy
Interventions: BEHAVIORAL: Internet delivered pain coping skills training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Will Having Alcohol Treatment Improve Functioning?
Status: COMPLETED
Conditions: HIV|Alcoholism
Interventions: DRUG: Naltrexone, 50mg, once per day for 4 months|OTHER: Sugar pill, 50mg, once per day for 4 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation and Neuropathic Pain After Thoracotomy and Continuous Application of Magnesium Sulphate.
Status: COMPLETED
Conditions: Atrial Fibrillation|Neuropathic Pain
Interventions: DRUG: Magnesium sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone|DRUG: rituximab and lenalidomide|DRUG: rituximab and bendamustine|DRUG: rituximab, cytarabine, dexamethasone, and oxaliplatin/carboplatin|DRUG: gemcitabine and oxaliplatin|BIOLOGICAL: Epcoritamab|DRUG: rituximab, cyclophosphamide, reduced dose of doxorubicin, vincristine, and prednisone|DRUG: Lenalidomide|DRUG: rituximab, ifosfamide, carboplatin, and etoposide phosphate|BIOLOGICAL: Epcoritamab|BIOLOGICAL: Epcoritamab|BIOLOGICAL: Epcoritamab|BIOLOGICAL: Epcoritamab|BIOLOGICAL: Epcoritamab|BIOLOGICAL: Epcoritamab|BIOLOGICAL: Epcoritamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Effect of Corticosteroids on Mylotarg® Infusion-Related Adverse Events in Patients With Leukemia
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute|Infusions, Intravenous
Interventions: DRUG: Mylotarg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy and Safety of Two New Formulations Compared to Gynomax® XL Ovule
Status: COMPLETED
Conditions: Trichomonal Vaginitis|Bacterial Vaginosis|Candidal Vulvovaginitis|Mixed Vaginal Infections
Interventions: DRUG: EVEGYN A|DRUG: EVEGYN B|DRUG: Gynomax® XL Vaginal Ovule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Reduced-dose Pomalidomide and Cyclophosphamide Combined With Dexamethasone in the Treatment of Patients With Debilitating RRMM
Status: RECRUITING
Conditions: Multiple Myeloma in Relapse
Interventions: DRUG: Pomalidomide, cyclophosphamide combined with dexametha
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema
Status: RECRUITING
Conditions: Visual Impairment|Neovascular Age-related Macular Degeneration (nAMD)|Diabetic Macula Edema (DME)
Interventions: DRUG: Aflibercept 8 mg (VEGF Trap-Eye, BAY86-5321)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of Positioning After Extubation of Preterm Infants on the Respiratory Functions
Status: COMPLETED
Conditions: Premature Infants
Interventions: OTHER: The effect of positioning on respiratory functions of preterm infants after extubation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial
Status: COMPLETED
Conditions: Intravenous Alteplase Thrombolysis|Neurological Improving
Interventions: DRUG: ginkgolide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Low-calorie and High-protein Diet Specially Rich in Animal Protein Compared to a Low-calorie and High-protein Diet Specially Rich in Plant Protein on Glucose Metabolism in Subjects With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Overweight and Obesity|PreDiabetes
Interventions: BEHAVIORAL: Low-calorie and high-protein diet with the majority of protein coming from animal sources.|BEHAVIORAL: Low-calorie and high-protein diet with the majority of protein coming from plant sources.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Interferon Gamma-1b With Rituximab in Non-Hodgkin's Lymphoma Patients
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Interferon Gamma-1b|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Trial to Evaluate Bioequivalency and Safety of Monoclonal Antibody Injection and Adalimumab in Chinese Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: human recombinant anti-tumor necrosis factor alpha monoclonal antibody injection|DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Understand Effectiveness and Safety of ABP 938 Compared to Aflibercept (Eylea®) in Patients Suffering With Neovascular Age-related Macular Degeneration [Neovascular (Wet) AMD]
Status: COMPLETED
Conditions: Neovascular (Wet) Age-related Macular Degeneration (AMD)
Interventions: DRUG: ABP 938|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy
Status: COMPLETED
Conditions: Abdominal Neoplasm|Colonic Neoplasm|Mesothelioma|Peritoneal Neoplasm
Interventions: PROCEDURE: Surgery|PROCEDURE: Continuous hyperthermic peritoneal perfusion (CHPP) with Cisplatin|DRUG: Postoperative dwell with paclitaxel and 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Remitoro in Participants With Recurrent or Refractory Peripheral T Cell Lymphoma and Cutaneous T Cell Lymphoma (All Case Study)
Status: COMPLETED
Conditions: Lymphoma, T-cell, Peripheral|Lymphoma, T-cell, Cutaneous
Interventions: DRUG: Remitoro
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.
Status: NOT_YET_RECRUITING
Conditions: Androgen Axis Suppression|Prostatectomy|Prostate Cancer
Interventions: DRUG: Apalutamide|DRUG: Androgen Deprivation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DISE-HNS Effect Study
Status: NOT_YET_RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: Hypoglossal nerve stimulation implant|DIAGNOSTIC_TEST: Polysomnography|PROCEDURE: Drug-induced sleep endoscopy (DISE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Paclitaxel in Patients With CLI and Femoropopliteal Occlusive Disease Treated With DCB Angioplasty
Status: COMPLETED
Conditions: Ischemia
Interventions: DEVICE: Angiogram, Medtronic DCB (paclitaxel)/stent|DEVICE: Angiogram, Bard DCB (paclitaxel)/stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bivalirudin Infusion for Ventricular Infarction Limitation
Status: TERMINATED
Conditions: Acute Myocardial Infarction
Interventions: PROCEDURE: PPCI|DRUG: Bivalirudin|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of YPEG-rhEPO in Patients Suffered From Anemia Due to Chronic Kidney Disease
Status: COMPLETED
Conditions: Renal Anemia of Chronic Kidney Disease
Interventions: DRUG: YPEG-rhEPO|DRUG: YPEG-rhEPO|DRUG: YPEG-rhEPO|DRUG: YPEG-rhEPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy Combined With Thymosin for Metastatic NSCLC Patients Who Showed Stable Disease After First Line TKI Therapy
Status: UNKNOWN
Conditions: Lung Adenocarcinoma
Interventions: DRUG: TKI|RADIATION: Thoracic Hypofractionated Radiotherapy|DRUG: Thymosin Alpha 1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT