pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: PENG Block Combined to Wound Infiltration for Hip Replacement
Status: COMPLETED
Conditions: Postoperative Pain|Analgesia|Hip Arthropathy|Acute Pain|Pain|Postoperative Complications
Interventions: PROCEDURE: PENG block|PROCEDURE: Wound Infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nigerian Breast Cancer Risk-Reduction Study
Status: COMPLETED
Conditions: Risk Reduction Behavior|Breast Cancer|Health Behavior|Health Care Utilization|Health Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: Individualized breast cancer risk assessment|BEHAVIORAL: Individualized breast cancer risk counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Costs and Consequences of Three Common Orthopedic Procedures on the Upper Extremity
Status: COMPLETED
Conditions: Degenerative Arthritis of Left Glenohumeral Joint|Degenerative Arthritis of Right Glenohumeral Joint|Rotator Cuff Tear Arthropathy|Rotator Cuff Tear|Trapeziometacarpal Osteoarthritis
Interventions: PROCEDURE: Operated TSA Patients|PROCEDURE: Operated RCR Patients|PROCEDURE: Resection interposition suspension arthroplasty (RISA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medacta GMK Sphere® Multicenter Post-Market Outcomes Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis
Interventions: DEVICE: Medacta GMK Sphere® Medial Knee Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Supraspinatus Tendon Assessment After 448kilohertz Radiofrequency Stimulation in a Sporty Population.
Status: COMPLETED
Conditions: Ultrasonography|Shoulder
Interventions: DEVICE: Monopolar 448 kilohertz radiofrequency stimulation|DEVICE: Placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Levetiracetam Administration for the Management of Levodopa-Induced Dyskinesias in Parkinson's Disease
Status: UNKNOWN
Conditions: Levodopa Induced Dyskinesia
Interventions: DRUG: Levetiracetam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Acute Promyelocytic Leukemia With All-Trans Retinoic Acid (ATRA) and Idarubicin (AIDA)
Status: COMPLETED
Conditions: Acute Promyelocytic Leukemia
Interventions: DRUG: AIDA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring a Lottery-promoted Gambling Disorder Screening Day Intervention
Status: NOT_YET_RECRUITING
Conditions: Gambling Problem
Interventions: BEHAVIORAL: Gambling Disorder Screening Day screener|BEHAVIORAL: Gambling Disorder Screening Day information sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: A Monocenter Prospective Study to Evaluate the Efficacy of Peripherally Inserted Central Catheter to Tunnelled Central Catheter With Cuff in Home Parenteral Nutrition for Long-term Used.
Status: TERMINATED
Conditions: Chronic Intestinal Failure
Interventions: DEVICE: group Piccnut|DEVICE: Tunnelled nutritional central catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ergometrine Versus Oxytocin in the Management of Atonic Post-partum Haemorrhage (PPH) in Women Delivered Vaginally
Status: UNKNOWN
Conditions: Post Partum Hemorrhage
Interventions: DRUG: Ergometrine|DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abduction Brace Versus Antirotation Sling for Immobilization Following Reverse Shoulder Arthroplasty and Rotator Cuff Repair
Status: WITHDRAWN
Conditions: Rotator Cuff Tear Arthropathy|Rotator Cuff Tear
Interventions: DEVICE: Abduction brace|DEVICE: Antirotation sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Recurrent C. Diff
Status: COMPLETED
Conditions: Clostridium Difficile Infection Recurrence
Interventions: DRUG: Full Spectrum Microbiota|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PF-04995274 and Emotional Processing in Treatment Resistant Depression
Status: COMPLETED
Conditions: Depression, Unipolar|Treatment Resistant Depression
Interventions: DRUG: PF-04995274|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Therapy With Ledipasvir/Sofosbuvir in Patients With Genotype 1 HCV Infection Receiving Opiate Substitution Therapy
Status: UNKNOWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: Sofosbuvir 400mg / Ledipasvir 90 mg (FDC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Vericiguat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Intrathecal and Intravenous VTS-270 Therapy for Liver and Neurological Disease Associated With Niemann-Pick Disease, Type C1
Status: TERMINATED
Conditions: Niemann-Pick Disease, Type C1
Interventions: DRUG: VTS-270
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maternal Mental Health Access - MaMa
Status: RECRUITING
Conditions: Postpartum Depression|Perinatal Depression
Interventions: BEHAVIORAL: Maternal Mental Health Access for Postpartum Depression- Prevention and UPLIFT- intervention|BEHAVIORAL: On-Demand + Discussion board (DB)|BEHAVIORAL: Arm 2|BEHAVIORAL: On Demand (OD) + Video Conference (VC)|BEHAVIORAL: Arm 3|BEHAVIORAL: On Demand (OD) + Video Conference (VC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multiple Dose Study in Heart Failure of BAY 1067197
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: BAY1067197 (10 mg)|DRUG: BAY1067197|DRUG: Placebo (10 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The IBEP Study: an Intervention for Lifestyle Modification in Women With Gestational Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes|Weight Gain During Pregnancy|Weight Loss After Pregnancy
Interventions: BEHAVIORAL: Intensive Behavioral Modification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ledipasvir/Sofosbuvir Treatment for Hepatitis C in HCT Recipients.
Status: WITHDRAWN
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Ledipasvir 90mg/Sofosubvir 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Feedback on Brushing Technique and Habits on Patient Oral Hygiene
Status: RECRUITING
Conditions: Toothbrushing|Oral Hygiene|Dental Plaque
Interventions: DEVICE: Electric toothbrush|BEHAVIORAL: Oral hygiene instructions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cryostimulation on Inflammation and Motor Functions. The Study Was Conducted to Determine the Effect of Five Days of Whole-body Cryostimulation (PBC) on Reducing Inflammation and Improving Motor Skills in Soccer Players
Status: COMPLETED
Conditions: Rest|Training
Interventions: OTHER: Criostymulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: All-Inside Single-Bundle for Anterior Cruciate Ligament Reconstruction With Full Thickness of the Peroneus Longus Tendon Compared to the Six-strand-hamstring Autograft (ACL)
Status: NOT_YET_RECRUITING
Conditions: Anterior Cruciate Ligament Injuries
Interventions: PROCEDURE: anterior cruciate ligament reconstruction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Postoperative Pain After Endoscopic TEP vs. Lichtenstein Hernioplasty in Inguinal Hernia Repair
Status: COMPLETED
Conditions: Inguinal Hernia|Hernia
Interventions: PROCEDURE: Tep surgery for inguinal hernia|PROCEDURE: Lichtenstein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia
Status: TERMINATED
Conditions: Iron Overload|Beta-Thalassemia
Interventions: DRUG: SP-420
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Protein and High Energy Intakes and Physical Activity on Growth of Extremely Low Birth Weight Infants
Status: UNKNOWN
Conditions: Infant, Very Low Birth Weight
Interventions: DIETARY_SUPPLEMENT: NUTR +|BEHAVIORAL: STIMUL +
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sputum Colour Charts to Guide Antibiotic Self-treatment of Acute Exacerbation of COPD (Colour COPD)
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: sputum colour chart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: STAAR-3 Clinical Study
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Renal Insufficiency|Kidney Disease|Pre-dialysis|Pre-ESRD
Interventions: DRUG: Darbepoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: OTHER: Mean arterial blood pressure (MAP) goal of ≥65 mmHg|OTHER: Mean arterial blood pressure (MAP) goal of 85-90 mmHg|OTHER: Spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MIGS VS SLT Comparison in Glaucoma Patients
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DEVICE: MIGS Hydrus Ivantis|PROCEDURE: 360 degrees SLT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: Operator Role Real TMS|DEVICE: Receiver Role Real TMS|DEVICE: Operator Role Sham TMS|DEVICE: Receiver Role Sham TMS|DEVICE: All Participants Operator Role
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Supraglottic Airway vs Tracheal Intubation on PPCs Among High-risk Geriatric Patients
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Complication
Interventions: DEVICE: laryngeal mask airway and endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess Safety, Tolerability, and Efficacy of GMI-1271 in Patients With Calf-level Deep Venous Thrombosis (DVT)
Status: TERMINATED
Conditions: Deep Venous Thrombosis
Interventions: DRUG: GMI-1271|DRUG: Enoxaparin Sodium (Lovenox®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Chronic Hepatitis C Infection in Adults With Genotype 1a Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: ABT-450/r/ABT-267, ABT-333|DRUG: Ribavirin|DRUG: Placebo for Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Sports-related Concussions on the Attention and Executive Skills of Adolescents and Young Adults: Links With Subjective Symptoms and Recovery
Status: COMPLETED
Conditions: Sports-related Concussion
Interventions: OTHER: Inclusion Questionnaires|OTHER: Questionnaires at inclusion, M1 and M3
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Compare Laparoscopic to Echographic Assisted Transversus Abdominis Plane Block in Laparoscopic Colectomy
Status: COMPLETED
Conditions: Laparoscopic Colectomy|Pain, Postoperative
Interventions: PROCEDURE: laparoscopic-assisted Transversus Abdominis Plane (TAP) block|PROCEDURE: ultrasound-assisted Transversus Abdominis Plane (TAP) block|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: CBD Treatment in Hand Osteoarthritis and Psoriatic Arthritis.
Status: COMPLETED
Conditions: Psoriatic Arthritis|Hand Osteoarthritis
Interventions: DRUG: Cannabidiol|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Electrical Acupoint Stimulation (TEAS) on Prevention Hypotension in Elderly
Status: COMPLETED
Conditions: Hypotension
Interventions: DEVICE: Transcutaneous Electrical Acupoint Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dietary Manipulation of the Microbiome-metabolomic Axis for Mitigating GVHD in Allo HCT Patients
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Bob's Red Mill®|OTHER: Starch Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Bortezomib in Combination With CC-5013 in Patients With Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma|Relapsed Multiple Myeloma|Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: CC-5013
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Single Center Trial to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Org 36286 (P07004)
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Org 36286|DRUG: Lyndiol®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects Probiotic Has on Gastromicroecology and Combined With Quadruple Regimen for H Pylori Infection
Status: UNKNOWN
Conditions: Efficacy|Gastric Microbiota|Safety
Interventions: OTHER: Compound Lactobacillus acidophilus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Evaluate the Long-Term Safety and Clinical Activity of mRNA-3705 in Participants Previously Enrolled in Other Clinical Studies of mRNA-3705
Status: RECRUITING
Conditions: Methylmalonic Acidemia
Interventions: DRUG: mRNA-3705
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IMC-C103C as Monotherapy and in Combination With Atezolizumab
Status: TERMINATED
Conditions: Select Advanced Solid Tumors
Interventions: DRUG: IMC-C103C|DRUG: Atezolizumab|DRUG: IMC-C103C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Long-term Intensive Home-based Physiotherapy on Older People With an Operated Hip Fracture or Frailty (RCT).
Status: COMPLETED
Conditions: Frail Elderly|Hip Fracture
Interventions: OTHER: Home-based physiotherapy (physical exercise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fish Oil and Folate Supplementation During Pregnancy
Status: COMPLETED
Conditions: Perinatal DHA and Folate Status|Neurological Development
Interventions: DIETARY_SUPPLEMENT: fish oil|DIETARY_SUPPLEMENT: folate|DIETARY_SUPPLEMENT: fish oil + folate|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin C on Allergy Skin Test
Status: RECRUITING
Conditions: Rhinitis, Allergic|Allergy
Interventions: DIETARY_SUPPLEMENT: Ascorbic acid 1000mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Sequential Optimization of Dose and Schedule of PfSPZ Vaccine
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: PfSPZ Vaccine|BIOLOGICAL: PfSPZ Challenge (NF54)|BIOLOGICAL: PfSPZ Challenge (7G8)|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I/II Study of Nab-paclitaxel and Gemcitabine Followed by AG-mFOLFOX in Patients With Metastatic Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: nab-paclitaxel|DRUG: gemcitabine|DRUG: m-FOLFOX|DRUG: nab-paclitaxel|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Air Pollution on Lung Health Among Children Living in Haifa Bay Region, Israel
Status: COMPLETED
Conditions: Bronchial Asthma|Signs and Symptoms, Respiratory|Allergy
Interventions: DEVICE: Spirometry (Pony spirometer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: HDAC Inhibitor Augmentation to Clozapine
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: Vorinostat Oral Capsule Group 1|DRUG: Vorinostat Oral Capsule Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of HemaMax™ (rHuIL-12) to Treat Acute Radiation Syndrome
Status: COMPLETED
Conditions: Hematopoietic Syndrome Due to Acute Radiation Syndrome
Interventions: BIOLOGICAL: HemaMax|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Therapeutic Exercise on the Gut Microbiome in Chronic Widespread Pain Patients.
Status: COMPLETED
Conditions: Arthritis|Fibromyalgia|Arthritis Rheumatoid|Artrosis of the Knee|Chronic Pain|Central Sensitisation|Gut Microbiota|Exercise Therapy
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Finding Study Of A New Medication, PF-00337210 That Will Possibly Decrease Blood Supply To Tumors
Status: COMPLETED
Conditions: Neoplasm
Interventions: DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210|DRUG: PF-00337210
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancer
Status: COMPLETED
Conditions: Advanced Adult Hepatocellular Carcinoma|Recurrent Hepatocellular Carcinoma|Stage III Hepatocellular Carcinoma AJCC v7|Stage IIIA Hepatocellular Carcinoma AJCC v7|Stage IIIB Hepatocellular Carcinoma AJCC v7|Stage IIIC Hepatocellular Carcinoma AJCC v7|Stage IV Hepatocellular Carcinoma AJCC v7|Stage IVA Hepatocellular Carcinoma AJCC v7|Stage IVB Hepatocellular Carcinoma AJCC v7|Unresectable Hepatocellular Carcinoma
Interventions: DRUG: Doxorubicin Hydrochloride|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacogenomic Study|DRUG: Sorafenib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability of MK0524A Versus Niacin Extended-Release (0524A-054)
Status: COMPLETED
Conditions: Hypercholesterolemia|Hyperlipidemia
Interventions: DRUG: niacin (+) laropiprant|DRUG: niacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study With YM543 in Type 2 Diabetes Mellitus Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: YM543|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Triple-masking v Double-masking: a Trial of Scientific Publication in Public Health
Status: RECRUITING
Conditions: Publication of Articles Submitted to the American Journal of Public Health
Interventions: OTHER: Triple-Masked|OTHER: Usual Procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Positive End Expiratory Pressure With A T-piece Resuscitator For Near-Term and Term Infants With Respiratory Distress
Status: COMPLETED
Conditions: Transient Tachypnea of the Newborn
Interventions: DEVICE: Neopuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma
Status: RECRUITING
Conditions: Metastatic Melanoma|Advanced Locoregional Melanoma|Metastatic Renal Cell Carcinoma|Clear Cell Histology
Interventions: DRUG: Pembrolizumab|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: IcoSema|DRUG: Semaglutide 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Risk ER+HER2- T1-2N0-1 Early Breast Cancer With Palbociclib Plus Endocrine Therapy(HIPEx)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celiac plExus Block to Reduce OpioID Consumption Following Hepato-pancreato-biliary Mini-invasive Surgery
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Liver, Cancer of, Primary Resectable
Interventions: DRUG: Ropivacaine 0.5%|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of PX0612 In The Treatment Of Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DIETARY_SUPPLEMENT: PX0612|DIETARY_SUPPLEMENT: Di-Calcium Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Determine Safety and Efficacy of FPlus for Wrinkle Treatment
Status: COMPLETED
Conditions: Facial Wrinkles and Rhytides Reduction
Interventions: DEVICE: FPlus RF device for wrinkles and rhytide reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Relationship Between Physical Function, Comorbidity and Cytogenetic Risk Group in Older Adults With Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: ACUTE MYELOGENOUS LEUKEMIA
Interventions: OTHER: Bedside assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Testing Nivolumab to Prevent Disease From Coming Back After Treatment in Patients With Acute Myeloid Leukemia, REMAIN Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|OTHER: Clinical Observation|PROCEDURE: Echocardiography|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Slow-Stream Expiratory Muscle Strength Training for Veterans With Dysphagia Living in Long-term Care
Status: WITHDRAWN
Conditions: Dysphagia, Oropharyngeal|Dysphagia|Dysphagia, Progressive|Aging|Aspiration Pneumonia|Cough
Interventions: DEVICE: Slow-Stream Expiratory Muscle Strength Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: "Effectiveness of Dual-Wavelength Laser Therapy in Third Molar Extraction Pain, Swelling, and Trismus"
Status: COMPLETED
Conditions: Molar, Third|Low-level Laser Therapy
Interventions: DEVICE: Dual wavelength low level laser|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Adolescent Polycystic Ovary Syndrome (PCOS)
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Oral Contraceptive Pills (Yasmin)|BEHAVIORAL: Lifestyle Modification|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clostridioides Difficile and Frailty
Status: COMPLETED
Conditions: Frail Elderly|Clostridioides Difficile|Geriatric Assessment|Faecal Microbiota Transplantation|Aged
Interventions: OTHER: Comprehensive geriatric assessment (CGA)|OTHER: Continued geriatric care|OTHER: Faecal microbiota transplantation (FMT)|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Low Dose hCG on Oocyte Maturity in Poor Responder Women Undergoing Intracytoplasmic Sperm Injection
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: rFSH|DRUG: hCG|DRUG: hCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1,Open -Label Study to Assess the Absorption, Metabolism and Excretion of 14C-OPS-2071 Following a Single Oral Dose to Healthy Male Japanese Subjects
Status: COMPLETED
Conditions: Bacterial Enteritis
Interventions: DRUG: 14C-OPS-2071
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Status: COMPLETED
Conditions: Sepsis|Delirium|Impaired Cognition
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Family-Centered Intervention Program for Preterm Infants: Effects and Their Biosocial Pathways
Status: COMPLETED
Conditions: Premature Birth
Interventions: BEHAVIORAL: Family-centered intervention program|BEHAVIORAL: Usual care intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination of Parasternal and Serratus Anterior Plane Block in Coronary Artery Bypass Graft Surgery
Status: COMPLETED
Conditions: Parasternal Block|Serratus Anterior Plane Block|Acute Pain|Postoperative Analgesia|Cardiac Surgery
Interventions: PROCEDURE: Combined parasternal block and serratus anterior plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atovaquone With Radical ChemorADIotherapy in Locally Advanced NSCLC
Status: COMPLETED
Conditions: Locally Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Atovaquone Oral Suspension|DRUG: Standard of care chemotherapy|RADIATION: Standard of care radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study With 99mTC - or 186 Re-labelled Humanised Monoclonal Antibody (hMAb) BIWA 4 in Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DRUG: 99mTc - labelled hMAb BIWA 4|DRUG: 186 Re - labelled hMAb BIWA 4|DRUG: unlabelled hMAb BIWA 4 - low dose|DRUG: unlabelled hMAb BIWA 4 - medium dose|DRUG: unlabelled hMAb BIWA 4 - high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Carotenoids From Orange Juice in a Cross-over Study in Healthy Subjects.
Status: COMPLETED
Conditions: Biological Availability|Carotenoids|Lutein|Humans
Interventions: OTHER: Orange juice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: BrUOG 263: Prostate Specific Membrane Antigen (PSMA) Glioblastoma Multiforme (GBM)
Status: COMPLETED
Conditions: GBM|Glioblastoma Multiforme|Gliosarcoma
Interventions: DRUG: PSMA ADC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Energy for the Brain
Status: COMPLETED
Conditions: Migraine|Episodic Migraine
Interventions: DIETARY_SUPPLEMENT: Beta-hydroxybutyrate calcium and magnesium salt|OTHER: placebo powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CPAP Treatment and Postoperative Outcomes in Patients With Rheumatic Valvular Heart Disease
Status: COMPLETED
Conditions: Rheumatic Valvular Heart Disease|Obstructive Sleep Apnea
Interventions: DEVICE: continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major
Status: NOT_YET_RECRUITING
Conditions: Thalassemia Major
Interventions: DRUG: n-acetylcystine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma
Interventions: RADIATION: Stereotactic Radiosurgery|DRUG: Nivolumab|DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Sarcoma
Status: COMPLETED
Conditions: Ovarian Cancer|Sarcoma
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: vincristine sulfate|PROCEDURE: adjuvant therapy|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery|RADIATION: brachytherapy|RADIATION: intraoperative radiation therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: ShotBloker and Helfer Skin Tap Technique During Intramuscular Injection in Children
Status: COMPLETED
Conditions: Pain, Acute|Fear|Emergencies|Child, Only|Injection Fear
Interventions: OTHER: Helfer skin tap technique|DEVICE: Shot Blocker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Dose Escalating Study of Intramuscular Invaplex[AR-DETOX]
Status: COMPLETED
Conditions: Diarrhea
Interventions: BIOLOGICAL: Invaplex[AR-DETOX]|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Timely Acquirement of 12-lead ECG Using Patchy-type Wireless Device Among Patient With Chest Pain
Status: COMPLETED
Conditions: Chest Pain|Electrocardiography
Interventions: DEVICE: patchy-type wireless 12-lead ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Hernia Repair Four Arm Comparative Study
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: open properitoneal hernia repair|PROCEDURE: Lechtestien hernia repair|PROCEDURE: Laparoscopic transperitoneal approach|PROCEDURE: Laparoscopic totally extraperitoneal approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Lumacaftor|DRUG: Ivacaftor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of BT and PFET on Urinary Symptoms and Quality of Life in Patients With OABS
Status: RECRUITING
Conditions: Overactive Bladder Syndrome (OABS)
Interventions: OTHER: Standard Patient Education|OTHER: bladder training|OTHER: pelvic floor exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toward a Real-time Access to Sleepers' Mental Content
Status: RECRUITING
Conditions: Memory Reactivation|Memory Consolidation|Sleepwalking
Interventions: BEHAVIORAL: differences of behavior between sleepwalking and non sleepwalking patient
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects on Ovarian Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing DRSP/EE (292003)(COMPLETED)(P05723)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: NOMAC-E2|DRUG: DRSP-EE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: B003 in Patients With HER2-positive Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer
Interventions: BIOLOGICAL: Recombinant anti-HER2 humanized monoclonal antibody conjugate for injection.R&D code: B003.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of A&D UA-651 in Children
Status: UNKNOWN
Conditions: Blood Pressure
Interventions: DEVICE: A&D UA-651 Blood Pressure Monitor|DEVICE: ADC 740-N Manual Sphygmomanometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LCZ696 in Subjects With Mild and Moderate Hepatic Impairment Compared With Normal Healthy Volunteers
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: LCZ696
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Acute Salt Handling in Orthostatic Intolerance
Status: ACTIVE_NOT_RECRUITING
Conditions: Postural Tachycardia Syndrome|Orthostatic Tachycardia|Orthostatic Intolerance
Interventions: OTHER: normal saline (0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diagnostic Performance of the Ultra Low-Dose (ULD) Scanner vs. Diagnostic Performance With Standard X-rays in the Emergency Department Compared With Performance of the Standard Classical-dose Scanner for Trauma of the Dorsolumbar Spine, Pelvis and Extremities
Status: RECRUITING
Conditions: Bone Fractures
Interventions: DIAGNOSTIC_TEST: Patient undergoes a ULD scan|DIAGNOSTIC_TEST: Patient undergoes a standard X-ray|DIAGNOSTIC_TEST: Patient undergoes a classic-dose scan
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of Torrent Pharmaceuticals Ltd's Nebivolol 20 mg Tablet
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Torrent's Nebivolol Tablets|DRUG: Forest Pharmaceuticals Inc.'s Bystolic Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Oral K201 for Prevention of AF Recurrence
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DRUG: K201 Tablet|DRUG: Placebo Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical and Radiographic Outcomes of Spine Surgeries Utilizing Capri Cervical and Thoracolumbar Corpectomy Cage Systems
Status: WITHDRAWN
Conditions: Thoracolumbar Spine|Cervical Spine Injury
Interventions: DEVICE: Capri Cervical Static|OTHER: CAPRI Static Expandable|DEVICE: Capri Thoracolumbar
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategies to Maintain Cardiac Risk Control After Discharge From Cardiovascular Risk Reduction Clinic
Status: COMPLETED
Conditions: Diabetes|Dyslipidemia|Hypertension|Coronary Atherosclerosis
Interventions: BEHAVIORAL: Counseling|BEHAVIORAL: Interactive Education|BEHAVIORAL: Group Support|PROCEDURE: Pharmacologic case management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: OCS-01: A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Eyedrops Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
Status: RECRUITING
Conditions: Disorders of the Eye Following Cataract Surgery
Interventions: DRUG: Dexamethasone|DRUG: Vehicle Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Anxiety and Stress for Healthier Eating in Teens
Status: UNKNOWN
Conditions: Obesity|Overweight|Anxiety|Mental Disorders|Body Weight|Eating Behavior|Feeding and Eating Disorders
Interventions: BEHAVIORAL: Interpersonal Psychotherapy (IPT)|BEHAVIORAL: Cognitive Behavioral Theory (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Evaluation Of Needle-based Confocal Laser Endomicroscopy in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas
Status: UNKNOWN
Conditions: Pancreatic Cyst|Pancreatic Neoplasms|Pancreatic Adenoma|Pancreatic Cancer|Pancreatic Islet Cell Tumors|Lymph Node|Lymphadenopathy
Interventions: PROCEDURE: EUS-FNA|DEVICE: nCLE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Serum and Synovium Protease Inhibitor Levels in Primary and Secondary Osteoarthritic Joints
Status: SUSPENDED
Conditions: Osteoarthritis of the Knee
Interventions: PROCEDURE: Blood Draw|PROCEDURE: Joint Aspirate Harvest|PROCEDURE: Blood Draw|PROCEDURE: Joint Aspirate Harvest
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migraine
Status: COMPLETED
Conditions: Chronic Migraine|Episodic Migraine
Interventions: DRUG: Atogepant 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lessons Learned From the Family Gene Toolkit
Status: COMPLETED
Conditions: Women With BRCA 1 or BRCA 2 Mutation|Non-tested Female Family Members
Interventions: BEHAVIORAL: Family Gene Toolkit|BEHAVIORAL: Delayed Family Gene Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Canola Oil Multi-Centre Intervention Trial II
Status: COMPLETED
Conditions: Cardiovascular Disease|Diabetes|Metabolic Syndrome
Interventions: OTHER: Regular Canola Oil|OTHER: High Oleic Canola Oil|OTHER: Western Type Diet - Common Dietary Oils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: T-cells or EBV Specific CTLs, Advanced B-Cell NHL and CLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: autologous or syngeneic PBTLs and EBV-CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Study of Vacuum Assisted Closure for Postsurgical Subcutaneous Abdominal Wound Healing Impairments
Status: COMPLETED
Conditions: Wound Healing Disorder|Impaired Wound Healing|Abdominal Wound Healing Disorder|Abdominal Wound Healing Impairment|Acute Postsurgical Subcutaneous Wound
Interventions: DEVICE: Vacuum Assisted Closure®|OTHER: Standard conventional wound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: β2-agonist Versus Ipratropium Bromide Associated With β2-agonists in Chronic Obstructive Pulmonary Disease Exacerbation
Status: COMPLETED
Conditions: Acute Exacerbation of Chronic Obstructive Airways Disease
Interventions: DRUG: Bricanyl/Iprovent|DRUG: Bricanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Clinical Study of Treating Tricuspid Regurgitation With K-Clip TM Transcatheter Annuloplasty System
Status: NOT_YET_RECRUITING
Conditions: Tricuspid Regurgitation
Interventions: DEVICE: Transcatheter Annuloplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Dexmedetomidine Versus Intravenous Dexmedetomidine for Improving Quality of Endoscopic Sinus Surgery
Status: RECRUITING
Conditions: Dexmedetomidine|Functional Endoscopic Sinus
Interventions: DRUG: intranasal dexmedetomidine|DRUG: intravenous dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
Status: COMPLETED
Conditions: Colonoscopy|Adjunct Anesthesia Medication
Interventions: DRUG: Diphenhydramine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1 Safety and Tolerability Study of MSK-DA01 Cell Therapy for Advanced Parkinson's Disease
Status: UNKNOWN
Conditions: Advanced Parkinson's Disease
Interventions: BIOLOGICAL: MSK-DA01|DEVICE: MSK-DA01 Cell Delivery Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT