pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combination of Sorafenib and Vorinostat in Poor-risk Acute Myelogenous Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS)
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute|Leukemia, Promyelocytic, Acute|Myelodysplastic Syndromes
Interventions: DRUG: Sorafenib-Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing an Oral EGFR Inhibitor, DZD9008 in Patients With Advanced Non-small Cell Lung Cancer(NSCLC) With EGFR Mutations (WU-KONG15)
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: DZD9008|DRUG: DZD9008
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy, Safety and Tolerability of BZ371A in Women With Sexual Arousal Disorder
Status: NOT_YET_RECRUITING
Conditions: Female Sexual Arousal Disorder|Female Sexual Dysfunction
Interventions: DRUG: BZ371A 7.5 mg (1.5 ml)|DRUG: BZ371A 5.0 mg (1.0 ml)|DRUG: BZ371A 2.5 mg (0.5 ml)|DRUG: Placebo (1.5 ml)|DRUG: Placebo (1.0 ml)|DRUG: Placebo (0.5 ml)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Memory Improvement Through Nicotine Dosing (MIND) Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Nicotine Transdermal Patch|DRUG: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vivaer® Procedure for Treatment of Nasal Airway Obstruction Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasal Airway Obstruction
Interventions: DEVICE: Vivaer ARC Stylus|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Non-invasive Neuromodulation on Food Desire, Chewing Pattern, Executive Functions and Oxidative Stress.
Status: COMPLETED
Conditions: Craving|Mastication Disorder|Memory Disorders|Executive Dysfunction|Transcranial Direct Current Stimulation|Inflammation|Oxidative Stress
Interventions: BEHAVIORAL: speech therapy for chewing + real tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Pharmacokinetics and Safety/Tolerability of Fimasartan and Atorvastatin in Healthy Male Volunteers.
Status: COMPLETED
Conditions: Hypertension, Hyperlipidemia
Interventions: DRUG: Fimasartan, Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Describing the Immunogenicity and Safety of Quadrivalent Recombinant Influenza Vaccine (RIV4) Versus a Licensed Quadrivalent-inactivated Influenza Vaccine (IIV4) (Fluarix® Quadrivalent) in Participants 18 Years of Age and Older in South Korea
Status: COMPLETED
Conditions: Influenza (Healthy Volunteers)
Interventions: BIOLOGICAL: Quadrivalent Recombinant Influenza Vaccine (RIV4)|BIOLOGICAL: Quadrivalent inactivated influenza vaccine (IIV4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of ImmuKnow® in the Management of Immunosuppressants in the Renal Transplant Patient
Status: TERMINATED
Conditions: Kidney Transplant Immunosuppression
Interventions: DRUG: adjustment of immunosuppressant dosages|DRUG: adjustment of the dosages of immunosuppressants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pembrolizumab + Defactinib In Pleural Mesothelioma
Status: WITHDRAWN
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Pembrolizumab|DRUG: Defactinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic UCB Therapy With EPO in Children With CP
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: PROCEDURE: Umbilical Cord Blood therapy|BIOLOGICAL: Erythropoietin alfa|OTHER: Rehabilitation|PROCEDURE: Placebo UCB|BIOLOGICAL: Placebo EPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Afinitor vs. Sutent in Patients With Metastatic Non-Clear Cell Renal Cell Carcinoma
Status: COMPLETED
Conditions: Advanced Non-clear Cell Renal Cell Carcinoma
Interventions: DRUG: Everolimus|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self-Fixating Mesh Versus Mesh Fixation With Tissue Glue in Laparoscopic Inguinal Hernia Repair
Status: ENROLLING_BY_INVITATION
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair applying tissue glue for mesh fixation|PROCEDURE: Laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair using self-fixating mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of a Forecasting System for Predicting Exacerbations of COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: COPD self care advice|BEHAVIORAL: Poor weather forecast warning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Topical Vitamin D3, Diclofenac or a Combination of Both to Treat Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: Diclofenac|DRUG: Diclofenac + Calcitriol|DRUG: Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double Randomized and Placebo Controlled Trail of Tianqi Pingchan Granule to Prevent Levodopa-Induced Dyskinesia
Status: UNKNOWN
Conditions: Levodopa-Induced Dyskinesia
Interventions: DRUG: Tianqi Pingchan Granule|DRUG: Tianqi Pingchan Granule Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Lucrin® Depot Efficacy and Safety Monitoring Study in Patients With Advanced Prostate Cancer and Lower Urinary Tract Symptoms (LUTS)
Status: COMPLETED
Conditions: Advanced Prostate Cancer|Lower Urinary Tract Symptoms
Interventions: DRUG: Leuprolide acetate Depot Susp. 11.25 mg (Poland), 3.75 mg (Ukraine)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Distribution, Metabolism and Excretion of [14C]AZD6765 After a Single-Dose Intravenous Administration
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: RADIATION: 150 mg [14C] AZD6765
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial of Recombinant Adenovirus Type 5 AIDS Vaccine
Status: UNKNOWN
Conditions: Acquired Immunodeficiency Syndrome
Interventions: BIOLOGICAL: Ad5-gag|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Neovista Ophthalmic System for the Treatment of Subfoveal CNV in Patients With AMD That Have Failed Primary Anti-VEGF Therapy
Status: COMPLETED
Conditions: Wet Age-related Macular Degeneration
Interventions: DEVICE: NeoVista Ophthalmic System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bundang Rehabilitative Impact Study of the Elbow Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: DRUG: 3ml-Rejuvinex|DRUG: 3ml-15%-dextrose solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lichen Sclerosus - Treatment With Triamcinolone Acetonide: Injections (Syringe and Needle) x Micro Injections (MMP Technique)
Status: RECRUITING
Conditions: Lichen Sclerosus of External Female Genital Organs
Interventions: PROCEDURE: Infiltration of triamcinolone acetonide (2mg/ml) through syringes and needles|PROCEDURE: Infiltration of triamcinolone acetonide (40 mg/ml) with needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effect of Different Ventilator Mods on Atelectasis in Patients Undergoing Laparoscopic Surgery
Status: COMPLETED
Conditions: Atelectasis|Atelectases, Postoperative Pulmonary
Interventions: PROCEDURE: VCV|PROCEDURE: PCV-VG|DIAGNOSTIC_TEST: lung ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HLA 10/10 Matched Unrelated Donor vs Haploidentical Allogenic Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Myeloproliferative Syndromes|Myelodysplastic Syndromes
Interventions: OTHER: Haplo donor stem cell transplantation|OTHER: HLA 10/10 MUD stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients
Status: UNKNOWN
Conditions: Analgesia|Postoperative Pain
Interventions: DRUG: Remimazolam Besylate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placement of Biliary Drainage Stent to Prevent Biliary Intestinal Anastomosis After Liver Transplantation in Children
Status: NOT_YET_RECRUITING
Conditions: Liver Transplant; Complications
Interventions: DEVICE: intraoperative plancement of Biliary Drainage Stent
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Enteral Immunonutrition on Immune, Inflammatory Markers and Nutritional Status in Patients Undergoing Gastrectomy for Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer|Enteral Immunonutrition
Interventions: DIETARY_SUPPLEMENT: enteral immunonutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Interaction Between Measles and DTP Vaccination
Status: COMPLETED
Conditions: Non-target Heterologous Effects of Vaccines|Vaccine Interactions
Interventions: BIOLOGICAL: Measles Vaccine at 9 months of age|BIOLOGICAL: DTP Vaccine at 9 months of age|BIOLOGICAL: Measles Vaccine at 18 months of age
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Registry Trial of The Bioheart Rapamycin Drug-Eluting Bioresorbable Coronary Stent System
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: The Bioheart Rapamycin Drug-Eluting Bioresorbable Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trials of Multivalent Opioid Vaccine Components
Status: RECRUITING
Conditions: Opioid-use Disorder
Interventions: DRUG: Placebo|DRUG: Oxy 25 mg|DRUG: OXY 50 mg|DRUG: OXY 100 mg|DRUG: Heroin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Early Mobilization on Pain Level After Laparoscopic Bariatric Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Morbid
Interventions: OTHER: experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Early Enteral Feeding on Splanchnic Blood Flow After Surgery for Critical Heart Disease in the Newborn
Status: TERMINATED
Conditions: Congenital Heart Disease
Interventions: OTHER: Continuous feeding at time 1 and NPO at time 2|OTHER: NPO at time 1 and continuous feeding at time 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Neoplasms
Interventions: DIETARY_SUPPLEMENT: Alpha-Tocopherol and Beta-Carotene|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Orally Dosed Emergency Contraception in Obese Women - LNG
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Levonorgestrel-based emergency contraception 1.5 mg|DRUG: Levonorgestrel-based emergency contraception 3.0mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dosimetry and Biodistribution of [18F]-Fludarabine in Lymphoid Malignancies
Status: COMPLETED
Conditions: Untreated B-Chronic Lymphocytic Leukemia or Diffuse Large B Cells Lymphoma Patients
Interventions: OTHER: [18F] - Fludarabine PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart Disease
Status: TERMINATED
Conditions: Pulmonary Arterial Hypertension|Congenital Heart Disease|Eisenmenger's Syndrome
Interventions: DRUG: Iloprost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fitting Evaluation of Hydrogel and Silicone Hydrogel Sphere Design Contact Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Omafilcon A|DEVICE: Somofilcon A|DEVICE: Omafilcon A - Proclear (PC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK3389404 in Chronic Hepatitis B (CHB) Subjects
Status: COMPLETED
Conditions: Hepatitis B
Interventions: DRUG: GSK3389404|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IMPACt of an Enhanced Screening Program on the Detection of Non-AIDS NEOplasms in HIV Patients
Status: UNKNOWN
Conditions: HIV/AIDS|Cancer
Interventions: DIAGNOSTIC_TEST: Digital rectal exam and / or anal cytology (day 1 and after 36 months)|DIAGNOSTIC_TEST: Semestral digital rectal exam and / or anal cytology if abnormal → ANOSCOPY with biopsy|DIAGNOSTIC_TEST: Cervical cytology and cervical sample for HPV detection (day 1 and after 36 months)|DIAGNOSTIC_TEST: Semestral cervical cytology and cervical sample for HPV detection|DIAGNOSTIC_TEST: Appointment for mammography (day 1 and after 36 months)|DIAGNOSTIC_TEST: Annual appointment for mammography|DIAGNOSTIC_TEST: Semestral appointment for liver ultrasound|DIAGNOSTIC_TEST: Semestral appointment for liver ultrasound|DIAGNOSTIC_TEST: Semestral blood collection for alpha-fetoprotein and others hepatic biomarkers determination|DIAGNOSTIC_TEST: Fecal occult blood test (day 1 and after 36 months)|DIAGNOSTIC_TEST: Annual fecal occult blood test|DIAGNOSTIC_TEST: Digital rectal exam and PSA determination (day 1 and after 36 months)|DIAGNOSTIC_TEST: Annual digital rectal exam and PSA determination|DIAGNOSTIC_TEST: Annual appointment for low dose computed tomography for lung screening|DIAGNOSTIC_TEST: Annual general inspection for skin lesions suggestive of malignancy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Trial Comparing the Effect of Pravastatin and Rosuvastatin on Atherosclerosis Progression Measured by Carotid Intima Media Thickness in Patients With Coronary Artery Disease After Biolimus Eluting Stent (Nobori®) Implantation: CPR IMT
Status: COMPLETED
Conditions: Coronary Artery Occlusive Disease
Interventions: DRUG: Pravastatin 40mg|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage IV Melanoma|Advanced Lung Cancer|Stage IV Non-Small Cell Lung Cancer|Unresectable Non-Small Cell Lung Carcinoma|Unresectable Stage III Non-Small Cell Lung Cancer|Small Cell Lung Cancer Extensive Stage|Stage IV Merkel Cell Carcinoma|Stage IV Cutaneous Squamous Cell Carcinoma|Stage IV Basal Cell Carcinoma|Stage IV Breast Cancer|Stage IV Colorectal Cancer|Stage IV Gastric Cancer|Stage IV Esophageal Cancer|Stage IV Hepatocellular Cancer|Stage IV Renal Cell Carcinoma|Stage IV Bladder Cancer|Stage IV Head and Neck Squamous Cell Carcinoma|Stage IV Cervical Cancer|Stage IV Endometrial Cancer|Stage IV Mesothelioma|Immunotherapy|Immune Checkpoint Inhibitors
Interventions: OTHER: Educational Video and QPL List|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tranexamic Acid in Urologic Surgery
Status: COMPLETED
Conditions: Bleeding|Prostatectomy
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Individual Sensitivity to the Gonadotoxicity of Chemotherapy in Young Patients With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: GENETIC: Blood sample for genetic test|BIOLOGICAL: Blood sample for hormonal measurement|OTHER: Ovarian ultrasound scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Safety and Effectiveness Trial of the Ventana Fenestrated Stent Graft System
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Ventana Fenestrated Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
Status: NOT_YET_RECRUITING
Conditions: Cardiogenic Shock|Post-cardiac Surgery|Cardiac Arrest|Extracorporeal Membrane Oxygenation Complication|Infections
Interventions: DIAGNOSTIC_TEST: Therapeutic drug monitoring of beta-lactam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Medical Management in Patients Exposed to Weapons of Mass Destruction
Status: ENROLLING_BY_INVITATION
Conditions: Chemical Injury|Chemicals; Intoxication|Acute Respiratory Distress Syndrome|Distress Respiratory Syndrome|Medical Emergencies
Interventions: PROCEDURE: Clinical interventions performed in acute settings (contaminated environment)|PROCEDURE: Protection (clinician and patient)|PROCEDURE: Decontamination (clinician and patient)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Trial of the Bilevel Positive Airway Pressure (by Boussignac) in Emergency Department of Non-invasive Patients Presenting With Acute Hypercapnic Respiratory Failure
Status: UNKNOWN
Conditions: Acute-on-chronic Respiratory Failure
Interventions: OTHER: non- invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Children's Oral Health Education With Different Education Methods
Status: COMPLETED
Conditions: Dental Caries in Children
Interventions: OTHER: Verbal Explanation|OTHER: Animation Video Display|OTHER: Peer-Led Reels Video Display
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pilot: Digital Therapeutic vs Education for the Management of Problematic Substance Use
Status: COMPLETED
Conditions: Alcohol Use Disorder (AUD)|Substance Use Disorders
Interventions: DEVICE: W-SUDs|OTHER: Digitally-delivered Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Lactobacillus Plantarum 299v Supplementation on Major Depression Treatment
Status: COMPLETED
Conditions: Depression|Anxiety Disorder
Interventions: DRUG: Lactobacillus Plantarum 299v|DRUG: Crystalline cellulose powder|DRUG: Escitalopram|DRUG: Sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dociparstat in Combination With Standard Chemotherapy for the Treatment of Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Dociparstat|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Beet Juice and Diet in Female Rowers
Status: COMPLETED
Conditions: Dietary Habits|Nitrates|Exercise
Interventions: DIETARY_SUPPLEMENT: Beet Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety/Tolerability and Efficacy of YHD001 in Patients With Acute and Chronic Bronchitis
Status: COMPLETED
Conditions: Acute Bronchitis|Chronic Bronchitis
Interventions: DRUG: YHD001 dose level 1|DRUG: YHD001 dose level 2|DRUG: Pelargonium sidoides extract|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Direct Current Stimulation in Post-stroke Aphasia
Status: WITHDRAWN
Conditions: Aphasia
Interventions: DEVICE: Active tDCS plus Speech-Language Therapy|DEVICE: Sham plus Speech-Language Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Inulin on Production of Phenolic Acids From Tomato Onion and Lovage Soup
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIETARY_SUPPLEMENT: Tomato, onion & lovage soup with inulin|DIETARY_SUPPLEMENT: Tomato, onion & lovage soup|DIETARY_SUPPLEMENT: Inulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of Teacher-Mediated Toilet Training Using a Manualized Moisture Alarm Intervention
Status: COMPLETED
Conditions: Autistic Disorder|Enuresis
Interventions: BEHAVIORAL: Moisture Pager Intervention for Toilet Training|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of Gut-directed Hypnotherapy in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders
Status: NOT_YET_RECRUITING
Conditions: Ehlers-Danlos Syndrome|Irritable Bowel Syndrome|Hypermobility Syndrome|Gastrointestinal Dysfunction
Interventions: BEHAVIORAL: Gut-directed hypnotherapy|OTHER: Standard Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zofin (Organicell Flow) for Patients With COVID-19
Status: COMPLETED
Conditions: Corona Virus Infection|COVID-19|SARS|Acute Respiratory Distress Syndrome
Interventions: BIOLOGICAL: Zofin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ED90 of Remimazolam Anesthesia Induction in Drug-induced Sleep Endoscopy in Adults
Status: RECRUITING
Conditions: Effect of Drug
Interventions: DRUG: Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Chronic Migraine Prophylaxis: Ultrasound-Guided Greater Occipital Nerve Block Versus Medical Treatment
Status: RECRUITING
Conditions: Greater Occipital Nerve Block|Medical Treatment|Chronic Migraine
Interventions: PROCEDURE: Greater Occipital Nerve Block|OTHER: Medical Treatment|DRUG: bupivacaine or onabotulinum toxin A injection.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Vitamin C, D and Zinc Supplementation on the Immune and Inflammatory Process in Type 2 Diabetic Subjects
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DIETARY_SUPPLEMENT: Vitamin Supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Keratinocyte Growth Factor to Prevent Autoimmunity After Alemtuzumab Treatment of Multiple Sclerosis
Status: TERMINATED
Conditions: Multiple Sclerosis
Interventions: DRUG: Palifermin|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimization of Analgesia for Hip Fracture Patients
Status: UNKNOWN
Conditions: Hip Fractures
Interventions: PROCEDURE: Fascia iliaca block|PROCEDURE: Femoral articular branches block(FAB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: human gp100 plasmid DNA vaccine|BIOLOGICAL: mouse gp100 plasmid DNA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BRIDGE Device for Treatment of Opioid Withdrawal
Status: TERMINATED
Conditions: Opioid Withdrawal|Pain|Craving
Interventions: DEVICE: Active BRIDGE device placement|DEVICE: Inactive BRIDGE device placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Glycopyrrolate on Vasopressors Requirement for Non-elective Caesarean Section Under Spinal Anaesthesia
Status: COMPLETED
Conditions: Glycopyrrolate|Post-spinal Hypotension|Effect of Drug|Hemodynamic Instability
Interventions: DRUG: Glycopyrrolate 0.2 MG/ML|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Hyperglycemia on Gastric Emptying Interactions With Pramlintide
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: placebo|DRUG: pramlintide|DRUG: placebo|DRUG: pramlintide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of the Effect of Distention Medium Temperature on Image Quality, Hyponatremia Risk, and Post-operative Pain in Operative Hysteroscopy
Status: RECRUITING
Conditions: Post-operative Pain
Interventions: PROCEDURE: Operative Hysteroscopy 24 Centigrade Degree|PROCEDURE: Operative Hysteroscopy 37 Centigrade Degree
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retrospective Observational Study of Patients With a Sutureless Aortic Valve Implanted in the Cardiovascular and Thoracic Surgery Department of Dijon CHU
Status: UNKNOWN
Conditions: Patients With a Sutureless Aortic Valve
Interventions: OTHER: Data collection|OTHER: Review of ECGs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS
Status: COMPLETED
Conditions: Hepatitis, Autoimmune
Interventions: DRUG: Chloroquine diphosphate 250mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Lenalidomide as Maintenance Therapy for Patients With B-Cell Chronic Lymphocytic Leukemia (CLL) Following Second Line Therapy
Status: COMPLETED
Conditions: B-cell Chronic Lymphocytic Leukemia
Interventions: DRUG: Lenalidomide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Different Local Anesthetic Volumes on Postoperative Analgesia for Thoracotomy Patients With Erector Spinae Plane Block
Status: COMPLETED
Conditions: Erector Spinae Plane Block|Local Anesthetic|Thoracotomy|Postoperative Analgesia
Interventions: PROCEDURE: Same blocks with different local anesthetic volume
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Preoperative Dienogest Therapy Followed by Surgery vs. Upfront Surgery to Save Ovarian Reserve in Young Women With Ovarian Endometrioma
Status: WITHDRAWN
Conditions: Ovarian Reserve|Endometriosis
Interventions: DRUG: Dienogest|DRUG: Placebo drug|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of DS-8500a in Japanese Subjects With Type 2 Diabetes Mellitus Receiving Sitagliptin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DS-8500a 25 mg|DRUG: DS-8500a 75 mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abituzumab in SSc-ILD
Status: TERMINATED
Conditions: Systemic Sclerosis-associated Interstitial Lung Disease
Interventions: DRUG: Abituzumab 1500 mg|DRUG: Abituzumab 500 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Remission and Hypoabsorptive Bariatric Surgery
Status: ENROLLING_BY_INVITATION
Conditions: Severe Obesity|Diabetes Mellitus, Type 2|Bariatric Surgery Candidate
Interventions: PROCEDURE: Duodenal Switch|PROCEDURE: SADI-S|PROCEDURE: Minigastric Bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Application Intervention on the Physiological Indicators and Low Protein Diet Cognition Among the Patients With Chronic Kidney Disease
Status: ENROLLING_BY_INVITATION
Conditions: CKD Stage 4|CKD Stage 5
Interventions: BEHAVIORAL: App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase II Study of BAY 43-9006 (Sorafenib) in Metastatic, Androgen-Independent Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: BAY 43-9006
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: tDCS as add-on Treatment to Cognitive-Behavior Therapy in People With MDD
Status: UNKNOWN
Conditions: Major Depressive Disorder|CBT|Transcranial Direct Current Stimulation
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Receptor Occupancy of ITI-007 Using Positron Emission Tomography (PET) in Patients With Stable Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: ITI-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 506U78 in Treating Patients With Refractory or Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: nelarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study: Vaginal Promestriene Use, Fractional CO2 LASER and Radiofrequency in the Vaginal Atrophy Treatment
Status: COMPLETED
Conditions: Vaginal Atrophy
Interventions: DRUG: Promestriene Vaginal|OTHER: Fractional CO2 LASER|OTHER: Microablative Fractional radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Deflazacort (Emflaza®) in Participants With Duchenne Muscular Dystrophy (DMD)
Status: WITHDRAWN
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Deflazacort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal Function
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Belantamab mafodotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONCE - Only Nocturnal Combination Evaluation of Antiretroviral-Experienced HIV 1 Infected Subjects Switching to Atripla
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Atripla (ATR) consisting of EFV 600 mg/FTC 200 mg/TDF 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resting Metabolic Rate, Fat Distribution, Endocrine and Metabolic Features in Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DIAGNOSTIC_TEST: SenseWear Armband (SWA) monitoring|DIAGNOSTIC_TEST: total body dual-energy X-ray absorptiometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of the EnkFiberoptic Atomizer Set on Usage of Anaesthetics During the Bronchoscopy
Status: COMPLETED
Conditions: Administration of Local Anaesthetics With a Special Atomizing Set Durching Fexible Bronchoscopy
Interventions: DEVICE: Enk Fiberoptic Atomizer|DEVICE: bronchoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Non-Guided vs. Guided Surgery to Immediately Loaded PrimeTaper Implants in Partially Edentulous Patients
Status: RECRUITING
Conditions: Partially Edentulous Maxilla or Mandible
Interventions: DEVICE: PrimeTaper EV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab for Treatment of R/R or MRD-positive CD19-Positive MPAL
Status: ACTIVE_NOT_RECRUITING
Conditions: Mixed Phenotype Acute Leukemia (MPAL)|Measurable Residual Disease (MRD)
Interventions: DRUG: BLINCYTO (Blinatumomab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Incobotulinum Toxin A Injections for Treatment of Tinnitus: a Randomized Controlled Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Tinnitus
Interventions: DRUG: incobotulinum toxin A|DRUG: Placebo-Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Hyperventilation Prior to CO2 Insufflation During Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy
Interventions: PROCEDURE: Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Internet Based Cognitive Behavior Therapy for Procrastination: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Procrastination
Interventions: BEHAVIORAL: Internet-based cognitive behavioural therapy (iCBT) without therapist contact.|BEHAVIORAL: Internet-based cognitive behavioural therapy (iCBT) with therapist contact.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bridge-Enhanced ACL Repair vs ACL Reconstruction
Status: ACTIVE_NOT_RECRUITING
Conditions: Anterior Cruciate Ligament Tear
Interventions: DEVICE: BEAR Scaffold|PROCEDURE: Tendon Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Plasma Rich in Growth Factors (PRGF) Treatment for Muscle Tear
Status: COMPLETED
Conditions: Muscle Tear
Interventions: BIOLOGICAL: PRGF|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KPT-9274 in Patients With Relapsed and Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Acute Myeloid Leukemia, in Relapse|Acute Myeloid Leukemia Refractory
Interventions: DRUG: KPT-9274
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Prostate-specific Antigen, Multi-parametric MRI and Targeted Prostate Biopsy for Prostate Cancer Screening
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: multi-parametric MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Online Occupational Therapy on Occupational Balance, Well-being and Quality of Life in Syrian Refugee Children
Status: COMPLETED
Conditions: Occupational Balance|Well-being|Quality of Life|Occupational Therapy|Refugee|Children
Interventions: BEHAVIORAL: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bedside Ultrasonic Assessment for Gastric Content in Patients With Upper GI Bleeding Undergoing Endoscopy: a Pilot Study
Status: RECRUITING
Conditions: Upper GI Bleeding|Point of Care Ultrasound|Upper Endoscopy|Gastric Content|GI Bleed
Interventions: DIAGNOSTIC_TEST: Point of Care Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mindfulness-Based Stress Reduction in Dementia Caregivers
Status: COMPLETED
Conditions: Mindfulness Based Stress Reduction|Caregiver Burnout|Caregiver Stress Syndrome|Dementia|Dementia Frontal|Frontotemporal Dementia|Frontotemporal Lobar Degeneration
Interventions: OTHER: Mindfulness-Based Stress Reduction|OTHER: Self-Guided Mindfulness eCourse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of GemCis Plus Trastuzumab Plus Pembrolizumab in Previously Untreated HER2-positive Biliary Tract Cancer
Status: RECRUITING
Conditions: Biliary Tract Cancer|HER2 Gene Mutation
Interventions: DRUG: SOC plus trastuzumab and pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of IPN59011 in Improving the Appearance of Moderate to Severe Upper Facial Lines.
Status: TERMINATED
Conditions: Moderate Upper Facial Lines|Severe Upper Facial Lines
Interventions: BIOLOGICAL: IPN59011|BIOLOGICAL: Azzalure|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer
Status: WITHDRAWN
Conditions: Thyroid Cancer
Interventions: DRUG: Thyrotropin Releasing Hormone (TRH)|DRUG: levothyroxine|OTHER: Hypothyroidism QOL questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neuroinflammation After Myocardial Infarction - Imaging Substudy
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Infarction
Interventions: DRUG: [18F]DPA-714-PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RADVAX™: A Trial of Combined Pembrolizumab and Hypofractionated Radiation in Patients With Advanced Urothelial Cancer Who Have Progressed on Anti-PD-1/PD-L1 Monotherapy
Status: WITHDRAWN
Conditions: Urothelial Cancer
Interventions: DRUG: PEMBROLIZUMAB|RADIATION: hypofractionated radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of BCL201 and Idelalisib in Patients With FL and MCL
Status: COMPLETED
Conditions: Follicular Lymphoma, Mantle Cell Lymphoma
Interventions: DRUG: BCL201|DRUG: Idelalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Evaluate Efficacy and Safety of First-Line Treatment With HLX10 + Chemotherapy in Patients With Advanced Cervical Cancer
Status: WITHDRAWN
Conditions: Cervical Cancer
Interventions: DRUG: HLX10|DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Placebo to HLX10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Safety and Efficacy of FID 120947A
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: FID 120947A contact lens disinfecting solution|DEVICE: Soft contact lenses (SCL)|DEVICE: SCL preservative solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess the Safety, Tolerability, and Pharmacokinetics of REGN5381 (an NPR1 Agonist) in Adult Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: REGN5381|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factors Influencing Cascade Testing Among Women With Hereditary Gynecological Cancers and Their Relatives
Status: COMPLETED
Conditions: Breast Carcinoma|Deleterious CDH1 Gene Mutation|Deleterious DICER1 Gene Mutation|Deleterious SMARCA4 Gene Mutation|Deleterious STK11 Gene Mutation|Endometrial Carcinoma|Fallopian Tube Carcinoma|Ovarian Carcinoma|Primary Peritoneal Carcinoma
Interventions: OTHER: Interview|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trabectedin in Treating Patients With Advanced, Persistent, or Recurrent Leiomyosarcoma of the Uterus
Status: COMPLETED
Conditions: Sarcoma
Interventions: DRUG: trabectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Share Safer Sex Counseling Program for Changing Sexual Risk Behaviors in Mexican Female Sex Workers
Status: COMPLETED
Conditions: HIV Infections|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Share Safer Sex program|BEHAVIORAL: Standard didactic safer-sex counseling program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Universal BCMA-targeted LUCAR-B68 Cells in Patients With Relapsed/Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapsed/Refractory Multiple Myeloma
Interventions: BIOLOGICAL: LUCAR-B68 cells product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT