pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A P3 Comparator Trial in Community Acquired Bacterial Pneumonia
Status: WITHDRAWN
Conditions: Community Acquired Pneumonia
Interventions: DRUG: Dalbavancin|DRUG: Linezolid|DRUG: Linezolid Placebo|DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fluticasone Propionate MDPI Compared With Fluticasone/Salmeterol MDPI in Adolescent and Adult Patients With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: FS MDPI|DRUG: Fp MDPI|DRUG: Placebo MDPI|DRUG: albuterol/salbutamol|DRUG: Beclomethasone dipropionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics Therapy of Mood Disorders
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Active Comparator: Probiotic|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of Platelet Rich Fibrin Versus Subepithelial Connective Tissue Graft for Soft Tissue Augmentation
Status: UNKNOWN
Conditions: Patients With at Least Single Missing Anterior Tooth|Thin Gingival Biotype
Interventions: PROCEDURE: Platelet Rich Fibrin|PROCEDURE: sub epithelial connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET Trial to Assess the Receptor Occupancy of Brexpiprazole in Adult Subjects With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Brexpiprazole 1mg to 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TMC435350-TiDP16-C109: A Safety Study for TMC435350 in an Oral Solution Containing Either 100, 200 or 400 mg Equivalent of TMC435350 or Placebo in Healthy Japanese Male Volunteers
Status: COMPLETED
Conditions: HCV
Interventions: DRUG: TMC435350
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Levitra (Vardenafil, BAY38-9456)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Augmentative and Alternative Communication in Children With Cerebral Palsy Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: BEHAVIORAL: Augmentative Alternative Communication|OTHER: Augmentative Alternative Communication Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: EN3835 for the Treatment of Edematous Fibrosclerotic Panniculopathy (Commonly Known as Cellulite)
Status: COMPLETED
Conditions: Edematous Fibrosclerotic Panniculopathy|Cellulite
Interventions: BIOLOGICAL: COLLAGENASE CLOSTRIDIUM HISTOLYTICUM|BIOLOGICAL: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Masitinib in Combination With FOLFIRI for Second-line Treatment of Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Masitinib (AB1010)|DRUG: FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Erlotinib in Treating Patients With Metastatic Pancreatic Cancer That Did Not Respond to Previous Treatment With Gemcitabine
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: erlotinib hydrochloride|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The RA PROTECTION Study
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: Vorso PROTECT System|DEVICE: Vorso PROTECT System - Sham (OFF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Brief Intervention for Alcohol Users With Interpersonal Trauma
Status: RECRUITING
Conditions: Heavy Drinking|Alcohol Drinking|Substance Use|Drinking Behavior
Interventions: BEHAVIORAL: Standard Brief Intervention|BEHAVIORAL: Trauma-Informed and Peer-Supported Brief Intervention|BEHAVIORAL: Assessment only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesia For Positioning Patient With Femur Fracture For Spinal Anaesthesia
Status: COMPLETED
Conditions: Femoral Fracture
Interventions: DRUG: Ropivacaine|DRUG: Fentanyl|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optical Coherence Tomography to Evaluate Paclitaxel-Eluting Balloons and Everolimus-Eluting Coronary Stents
Status: COMPLETED
Conditions: Stents|Neointimal Proliferation
Interventions: DEVICE: Percutaneous coronary intervention with stent implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lacripep™ in Subjects With Dry Eye Associated With Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Primary Sjögren Syndrome|Dry Eye
Interventions: DRUG: 0.005% Lacripep|DRUG: 0.01% Lacripep|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci
Status: COMPLETED
Conditions: Osteomyelitis
Interventions: DRUG: daptomycin|DRUG: daptomycin|DRUG: vancomycin|DRUG: teicoplanin|DRUG: nafcillin|DRUG: oxacillin|DRUG: flucloxacillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Hand Functions In Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Hand Functions
Interventions: OTHER: TT+CIMT+VR|OTHER: TT+CIMT|OTHER: TT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Project: Every Child for Younger Patients With Cancer
Status: RECRUITING
Conditions: Adrenal Gland Pheochromocytoma|Carcinoma In Situ|Central Nervous System Neoplasm|Childhood Immature Teratoma|Childhood Langerhans Cell Histiocytosis|Childhood Mature Teratoma|Congenital Mesoblastic Nephroma|Desmoid Fibromatosis|Ganglioneuroma|Lymphoproliferative Disorder|Malignant Neoplasm|Malignant Solid Neoplasm|Melanocytic Neoplasm|Myeloproliferative Neoplasm|Neoplasm of Uncertain Malignant Potential|Neuroendocrine Neoplasm|Stromal Neoplasm
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Medical Chart Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dabigatran Adherence Pilot Intervention for Patients With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: BEHAVIORAL: Intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: First Autologous Transplant on Minimal Residual Disease Markers in Previously Untreated Myeloma Undergoing Initial Treatment With Velcade
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: VELCADE|DRUG: Lenalidomide|DRUG: Dexamethasone|DRUG: DVT prophylaxis|DRUG: Bisphosphonates|DRUG: Liposomal doxorubicin|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shared Decision Making to Improve Care and Outcomes for Children With Autism
Status: COMPLETED
Conditions: Autistic Disorder|Pervasive Developmental Disorder|Child Development Disorders, Pervasive|Asperger Syndrome|Autism Spectrum Disorder|Autism
Interventions: OTHER: Decision Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nasal Intubation Using King Vision Video Laryngoscopy
Status: COMPLETED
Conditions: Nasal Intubation
Interventions: DEVICE: King Vision video laryngoscope|DEVICE: McGrath MAC video laryngoscope|DEVICE: Macintosh laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Castration-sensitive Prostate Cancer
Interventions: DRUG: Niraparib|DRUG: Abiraterone acetate (AA)|DRUG: Prednisone|DRUG: Placebo for Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Additional Hyperbaric Oxygen After Lower Extremity Amputation
Status: RECRUITING
Conditions: Diabetes Mellitus|Claudication, Intermittent|Critical Limb Ischemia|Osteomyelitis|Amputation|Lower Extremity Ulcer|Diabetic Angiopathy|Diabetic Neuropathies|Diabetic Foot
Interventions: PROCEDURE: Hyperbaric oxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NMES to Prevent Respiratory Muscle Atrophy in Mechanically Ventilated Patients
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication|Neuromuscular Electrical Stimulation|Muscle Weakness
Interventions: DEVICE: VentFree prototype (VF03-K) active stimulation|DEVICE: VentFree prototype (VF03-K) sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Fluoride Dose Response Using In Situ Caries Model
Status: COMPLETED
Conditions: Caries
Interventions: DRUG: 0 ppm F|DRUG: 250 ppm F as MFP|DRUG: 1100 ppm as MFP|DRUG: 2800 ppm F as MFP|DRUG: 1100 ppm SnF2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Reducing Exercise-induced Bronchoconstriction in Children With Asthma and Obesity
Status: TERMINATED
Conditions: Asthma in Children|Obesity, Childhood|Exercise Induced Bronchospasm
Interventions: DRUG: Albuterol Sulfate|BEHAVIORAL: Interval Warm-up exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Agili-CTM Implant Performance Evaluation in the Treatment of Osteoarthritis of the Great Toe
Status: COMPLETED
Conditions: Osteoarthritis of Multiple Joints of Ankle or Foot
Interventions: DEVICE: Agili-CTM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Antibody Response of Healthy Chinese Children Who Have Been Vaccinated Previously With 4-doses of Prevenar (a Pneumococcal Vaccine) as Babies and Toddlers
Status: COMPLETED
Conditions: Pneumococcal Disease
Interventions: PROCEDURE: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome
Status: COMPLETED
Conditions: Iron Deficiency|Restless Leg Syndrome
Interventions: DIETARY_SUPPLEMENT: Probiotics|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The First Puncture Success Rate of a Novel Injeq IQ-Tip™ System in Pediatric Lumbar Punctures
Status: COMPLETED
Conditions: Lumbar Puncture
Interventions: DEVICE: IQ-Tip(tm) system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy Study of a Biologic to Treat Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Lupus
Interventions: DRUG: BMS-931699|DRUG: Placebo matching BMS-931699
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction
Status: RECRUITING
Conditions: Sleep Deprivation
Interventions: OTHER: Sleep Deprivation|OTHER: Heart Rate|OTHER: Sleep Monitoring|OTHER: Diet|OTHER: Exercise Performance|BEHAVIORAL: Surveys, McGill Pain Questionnaire, Shortened Profile of Mood States, Pittsburg Sleep Index|OTHER: Cognitive performance|OTHER: Marksmanship Performance|OTHER: Quick Board|OTHER: Advanced Medical Technologies Inc, Jump Test|OTHER: CGM/CKM|BIOLOGICAL: Blood Draw|DIETARY_SUPPLEMENT: Ketone Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: MK0752 and Gemcitabine Hydrochloride in Treating Patients With Stage III and IV Pancreatic Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Notch signaling pathway inhibitor MK0752|DRUG: gemcitabine hydrochloride|OTHER: imaging biomarker analysis|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib + Nivolumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed or Recurred Within Six Months After Platinum-based Chemotherapy
Status: TERMINATED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Abemaciclib|DRUG: Nivolumab|PROCEDURE: Tumor biopsy|PROCEDURE: Peripheral blood|OTHER: EORTC QLQ-30
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate ICP-022 in Patients With R/R PCNSL and SCNSL
Status: ACTIVE_NOT_RECRUITING
Conditions: PCNSL|Secondary Central Nervous System Lymphoma
Interventions: DRUG: ICP-022
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance of the SPIRION Laryngeal Pacemaker in BVFP Patients With Single-sided Glottal Enlargement
Status: RECRUITING
Conditions: Bilateral Vocal Cord Paralysis
Interventions: DEVICE: SPIRION Laryngeal Pacemaker System Implantation and follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Linezolid to Treat Extensively-Drug Resistant Tuberculosis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis|Multidrug Resistant Tuberculosis|Extensively Drug Resistant Tuberculosis
Interventions: DRUG: Immediate Start Linezolid|DRUG: Delayed Start Linezolid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen for the Prevention of Breast Cancer in High-Risk Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Tamoxifen Citrate 20Mg Tab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study To Evaluate Different Formulations Of PF-06865571 In Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06865571 Immediate release suspension|DRUG: PF-06865571 Slow release MR tablets|DRUG: PF-06865571 Fast release MR tablets|DRUG: PF-06865571 Immediate release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults
Status: COMPLETED
Conditions: Memory Deficits
Interventions: DRUG: Whole coffee cherry extract (WCCE)|DRUG: Placebo Oral Capsule [CEBOCAP]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and the Safety of Insulin Detemir in Subjects With Insulin Requiring Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin detemir|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effects of the Pulsed-dye Laser at 585nm and 595nm to Treat Post-operative Scars on Suture-removal Day
Status: COMPLETED
Conditions: Cicatrix|Scars
Interventions: PROCEDURE: PDL 450 microseconds|PROCEDURE: PDL 1.5 milliseconds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Irrigation Versus Suction in Complicated Acute Appendicitis
Status: UNKNOWN
Conditions: Appendicitis|Abdominal Abscess|Acute Disease|Cecal Diseases|Infection
Interventions: PROCEDURE: Irrigation|PROCEDURE: No irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing
Status: TERMINATED
Conditions: Osteoarthritis|Post-traumatic Arthritis|Collagen Disorders|Avascular Necrosis|Congenital Hip Dysplasia|Slipped Capital Femoral Epiphysis
Interventions: DEVICE: Pinnacle™ Acetabular System|DEVICE: Pinnacle™ Acetabular System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Stereotactic Navigation in Laparoscopic Surgery for Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: OTHER: Intraoperative acquisition (robotic c-Arm) of images
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rasburicase for the Treatment/Prevention of Hyperuricemia in Adult Patients With Relapsing Aggressive Non Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Hyperuricemia
Interventions: DRUG: Rasburicase (SR29142)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effectiveness of Clinicians and Paraprofessionals to Reduce Disparities in Perinatal Depression
Status: COMPLETED
Conditions: Perinatal Depression|PostPartum Depression
Interventions: BEHAVIORAL: Mothers and Babies Groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Lactobacillus Plantarum PS128 in Children With ASD
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DIETARY_SUPPLEMENT: PS128|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pevonedistat, Azacitidine (or Decitabine), and Venetoclax for the Treatment of Patients With Acute Myelogenous Leukemia
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia
Interventions: DRUG: Azacitidine|DRUG: Venetoclax|DRUG: Pevonedistat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Rehabilitation for Long COVID (Post COVID-19 Condition)
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|Long COVID|Post COVID-19 Condition
Interventions: OTHER: Pulmonary rehabilitation in primary care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetic Profiles of MOTREM (LR12) in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: nangibotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical Resection
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: DRUG: Docetaxel|DRUG: Erlotinib|OTHER: Placebo|BEHAVIORAL: Questionnaires|BEHAVIORAL: Phone Call|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Foot Orthoses (FOs) on Pain, Quality of Life and the Gait With Children Diagnosed With JIA
Status: COMPLETED
Conditions: Arthritis, Juvenile Rheumatoid
Interventions: DEVICE: Trial Foot Orthoses (FOs)|DEVICE: placebo foot orthoses (FOs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial
Status: COMPLETED
Conditions: Healthy|Overweight and Obesity|Metabolic Syndrome|PreDiabetes|Diabetes|Overweight|Obesity|Dysglycemia|Cardiovascular Diseases|Cardiovascular Risk Factor|Hypertension
Interventions: OTHER: Sugar-sweetened beverage (SSB)|OTHER: Non-nutritive sweetened beverages (NSB)|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial for Vaccine Therapy With Dendritic Cells in Patients With Metastatic Malignant Melanoma
Status: TERMINATED
Conditions: Metastatic Malignant Melanoma
Interventions: BIOLOGICAL: Dendritic cells - transfected with hTERT-, survivin- and tumor cell derived mRNA + ex vivo T cell expansion and reinfusion|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of AIN457 in Adults (18-65 Years) With Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: BIOLOGICAL: AIN457A|OTHER: Other
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prontosan Versus Saline in the Cleansing of Chronic Leg Ulcers in Diabetic Patients
Status: WITHDRAWN
Conditions: Diabetic Complications
Interventions: DEVICE: Prontosan|DEVICE: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Coronary Revascularization Versus Conservative Therapy in Patients With Treated Critical Limb Ischemia
Status: UNKNOWN
Conditions: Obstructive Coronary Artery Disease
Interventions: DEVICE: FFR-guided coronary revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Navigating Together for Equitable Asthma Management for Children in Families Who Communicate in Language Other Than English
Status: ENROLLING_BY_INVITATION
Conditions: Asthma in Children
Interventions: OTHER: Experimental: Nav-Team
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Sirolimus-Coated Balloon Versus Paclitaxel-Coated Balloon for the Treatment of Coronary In-Stent Restenosis
Status: COMPLETED
Conditions: Coronary Artery Disease|In Stent Restenosis
Interventions: DEVICE: drug-coated balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Habit Formation Theory for Exercise in Older Adults
Status: COMPLETED
Conditions: Sedentary Behavior|Aging|Activity, Motor|Behavior, Health
Interventions: BEHAVIORAL: Goal setting|BEHAVIORAL: Action Planning|BEHAVIORAL: Self-monitoring of behavior|BEHAVIORAL: Behavioral Practice/Rehearsal|BEHAVIORAL: Habit Formation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC)
Status: WITHDRAWN
Conditions: Peritoneal Carcinomatosis|Peritoneal Metastases|Colorectal Cancer|Gastric Cancer|Breast Cancer|Pancreas Cancer|Carcinoembryonic Antigen
Interventions: BIOLOGICAL: anti-CEA CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Awake Local Anesthesia Infiltration Compared to Regional Nerve Block for Hand Surgeries
Status: COMPLETED
Conditions: Anaesthesia Conduction
Interventions: OTHER: local anaesthesia infiltration|OTHER: brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Effect of IMB Model-Based Diabetes Education and Motivational Interviewing on Care Outcomes in Adults With T2DM
Status: COMPLETED
Conditions: Type2 Diabetes|Self Efficacy|Self Management|HbA1c|BMI
Interventions: BEHAVIORAL: IMB model based Diabetes Education and Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cortisol Control of Human Inflammatory Responses to Endotoxin
Status: COMPLETED
Conditions: Sepsis
Interventions: OTHER: Çontrol|DRUG: Hydrocortisone|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study of AZD9150 and MEDI4736 (Durvalumab) in Japanese Adult Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Advanced Solid Malignancies
Interventions: DRUG: AZD9150, Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EMR Versus ESD for Resection of Large Distal Non-pedunculated Colorectal Adenomas
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: PROCEDURE: EMR|PROCEDURE: ESD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Incidence of Shoulder Pain According to Postoperative Use of Abdominal Binder
Status: UNKNOWN
Conditions: Shoulder Pain
Interventions: DEVICE: abdominal binder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bone Marrow Transplantation in Treating Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Cyclophosphamide|PROCEDURE: Allogeneic Bone Marrow Transplantation|PROCEDURE: Autologous Bone Marrow Transplantation|RADIATION: Total Body Irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ofatumumab in Japanese Patients With CD20 Positive Follicular Lymphoma or Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukaemia, Lymphocytic, Chronic and Lymphoma, Follicular
Interventions: DRUG: ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome
Status: RECRUITING
Conditions: Twin to Twin Transfusion as Antepartum Condition|Monochorionic Diamniotic Placenta
Interventions: PROCEDURE: Fetoscopic laser ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects
Status: COMPLETED
Conditions: Furcation Defects
Interventions: PROCEDURE: Conventional Flap surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
Status: RECRUITING
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: Fetoscopic Endoluminal Tracheal Occlusion Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety of Continuous IV Tirofiban in Acute Ischemic Stroke
Status: WITHDRAWN
Conditions: Acute Ischemic Stroke|Ischemic Stroke
Interventions: DRUG: Tirofiban Hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: R±CEOP90 Versus R±CEOP75 in Newly Diagnosed Young Patients With Medium/High-risk DLBCL
Status: UNKNOWN
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: High-dose Epirubicin Combined with CVP ± Rituximab|DRUG: Standard-dose Epirubicin Combined with CVP ± Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes
Status: RECRUITING
Conditions: Healthy Subjects|Obesity|Type 2 Diabetes
Interventions: DRUG: TLC-6740 Oral Solution|OTHER: Placebo|DRUG: TLC-6740 Tablet|DRUG: Drug Metabolizing Enzyme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-CD19 and Anti-CD22 Immunotoxins in Treating Patients With Refractory or Relapsed B-Cell Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: deglycosylated ricin A chain-conjugated anti-CD19/anti-CD22 immunotoxins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on Brimonidine 0.2%/Timolol 0.5% Fixed Combination Therapy (COMBIGAN®) in Latin America
Status: COMPLETED
Conditions: Glaucoma
Interventions: DRUG: Brinzolamide/timolol maleate fixed combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Varied Outreach Methods on Appointment Scheduling, Appointment Completion, and Receipt of COVID-19 Vaccination
Status: COMPLETED
Conditions: Health Care Utilization|Vaccine Preventable Disease
Interventions: OTHER: Low tailored message|OTHER: No message|OTHER: Low tailored message plus COVID-19 vaccine message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Apremilast 30mg Bid With Narrowband UVB in the Treatment of Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitor and Sepsis
Status: NOT_YET_RECRUITING
Conditions: Sepsis|Inflammation|SGLT2 Inhibitors|Critically Ill|Organ Dysfunction Syndrome
Interventions: DRUG: Empagliflozin 10 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety and Pharmacokinetics of MMX Mesalamine in Children and Adolescents With Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: MMX Mesalamine|DRUG: MMX Mesalamine|DRUG: MMX Mesalamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis
Status: COMPLETED
Conditions: Pancreatic Insufficiency|Cystic Fibrosis|Digestive System Diseases|Lung Diseases|Respiratory Tract Diseases
Interventions: DRUG: Burlulipase|DRUG: Placebo (Caramel in sterile water)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Control Trial on Intravenous Paracetamol Versus Intramuscular Tramadol as Intra Partum Labor Analgesia
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy
Status: COMPLETED
Conditions: Excessive Daytime Sleepiness|Cataplexy|Narcolepsy
Interventions: DRUG: FT218|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Chemopreventive Agents on Disease-free and Overall Survival in Patients With Pancreatic Ductal Adenocarcinoma: The CAOS Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Disease Free Survival|Overall Survival|Pancreatic Cancer
Interventions: BEHAVIORAL: use of targeted drugs such as aspirin, B-Blockers, Metformin, ACE-inhibitors, Statins
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Asthma Crisis in Paediatrics: Impact of a Care Pathway in Primary and Hospital Care
Status: RECRUITING
Conditions: Asthma in Children|Implementation Science|Inappropriate Prescribing
Interventions: BEHAVIORAL: The implementation strategy to encourage the adoption of the Care Pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Efficacy and Safety of Dapagliflozin in Japanese Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate ACDN-01 in ABCA4-related Retinopathy (STELLAR)
Status: RECRUITING
Conditions: Stargardt Disease|Cone Rod Dystrophy|Juvenile Macular Degeneration|Stargardt Disease 1
Interventions: DRUG: ACDN-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Administration of Peginterferon Alfa-2a [Pegasys] by Autoinjector Versus Pre-filled Syringe in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DEVICE: Autoinjector|DEVICE: Pre-filled syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Diagnostic Accuracy of Ultrasonic Flow Ratio in Assessment of Left Main Coronary Artery Stenosis
Status: RECRUITING
Conditions: Left Main Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: fractional flow reserve (FFR); ultrasonic flow ratio (UFR); intravascular ultrasound (IVUS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Intradialytic Cognitive and Physical Exercise Training on Functional Status of Hemodialysis Patients
Status: COMPLETED
Conditions: Cognitive Dysfunction|Physical Inactivity|Chronic Kidney Diseases
Interventions: OTHER: Cognitive and physical exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carboplatin Plus Paclitaxel With or Without Continued Low-Dose Paclitaxel in Treating Patients With Early-Stage Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery
Status: COMPLETED
Conditions: Endophthalmitis
Interventions: DRUG: Cefuroxime|DRUG: Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Interventions in Adults With Depressive and Anxious Symptoms
Status: RECRUITING
Conditions: Anxiety|Depression
Interventions: BEHAVIORAL: Electrostimulation Therapy|BEHAVIORAL: Relaxation|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacology Study of BMS-866949
Status: TERMINATED
Conditions: Major Depression
Interventions: DRUG: Placebo|DRUG: BMS-866949|DRUG: BMS-866949|DRUG: BMS-866949|DRUG: BMS-866949|DRUG: BMS-866949|DRUG: BMS-866949|DRUG: BMS-866949
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Concept Study of a Sucker Hemostatic Intra Uterine in Postpartum Hemorrhage After Abruptio Placenta Assisted
Status: TERMINATED
Conditions: No Placental Abruption|No Hemorrhage
Interventions: DEVICE: Suction cup Hemostatic Intra-Uterine, device not marked CE (not marketed)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fed, Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Subjects
Status: COMPLETED
Conditions: Therapeutic Equivalency
Interventions: DRUG: Pravastatin|DRUG: Pravastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daily Vitamin D Supplementation Compared to a Loading Dose and Monthly Supplementation in Elderly Nursing Home Residents
Status: COMPLETED
Conditions: Vitamin D Deficiency in Older Persons
Interventions: DIETARY_SUPPLEMENT: loading dose Vitamin D and 50.000 IU vit D3/month|DIETARY_SUPPLEMENT: loading dose and 25.000 IU vit D3/month|DIETARY_SUPPLEMENT: Vitamin D 800 IU /day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tivozanib in Recurrent, Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Recurrent Epithelial Ovarian Cancer|Recurrent Fallopian Tube Cancer|Recurrent Primary Peritoneal Cancer
Interventions: DRUG: Tivozanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Utility of Peri-operative Arnica Montana for Reduction of Ecchymosis in Rhinoplasty Surgery
Status: COMPLETED
Conditions: Ecchymosis
Interventions: DRUG: Arnica montana|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxycodone/Naloxone Prolonged Release (OXN PR) Compared to Placebo to Demonstrate Improvement in Symptoms of Restless Legs Syndrome (RLS) in Subjects With Moderate to Severe Idiopathic RLS With Daytime Symptoms
Status: COMPLETED
Conditions: Moderate to Severe Idiopathic RLS With Daytime Symptoms
Interventions: DRUG: Oxycodone naloxone prolonged release tablets (OXN PR)|OTHER: Placebo (PLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Vitamin B12 Contains Extract of Lamb's Stomach in Treatment of Chronic Atrophic Gastritis (CAG)
Status: COMPLETED
Conditions: Chronic Atrophic Gastritis (CAG)
Interventions: DRUG: Gastropylor Complex Capsules|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Taste And Smell TEsting in End Stage Renal Disease
Status: WITHDRAWN
Conditions: Kidney Failure, Chronic|Olfaction Disorders|Taste Disorders|Malnutrition
Interventions: OTHER: Worsening of olfaction from enrollment visit to 6 months|OTHER: Worsening of taste from enrollment visit to 6 months|OTHER: Serum Zinc|OTHER: Chronic rhinosinusitis|OTHER: Dialysis adequacy|OTHER: Decayed missing filled teeth index (DMFT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiation Therapy and Chemotherapy in Treating Patients With Locally Advanced Cervical Cancer
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Squamous Cell Carcinoma|Stage IB Cervical Cancer|Stage IIA Cervical Cancer|Stage IIB Cervical Cancer|Stage III Cervical Cancer|Stage IVA Cervical Cancer
Interventions: DRUG: Topotecan Hydrochloride Liposomes|RADIATION: 3-Dimensional Conformal Radiation Therapy|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Riamet® Versus Malarone® in the Treatment of Uncomplicated Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Malarone (atovaquone + proguanil combination)|DRUG: RIAMET (artemether + LUMEFANTRIN combination)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-hospital Cardiac Arrest - Dynamics and State Transitions
Status: COMPLETED
Conditions: Heart Arrest|Death, Sudden, Cardiac
Interventions: PROCEDURE: Cardiopulmonary resuscitation (CPR)|DRUG: Epinephrine|DRUG: Atropine|DRUG: Amiodarone|DEVICE: External defibrillator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study for Safety and Immunogenicity of BCG and AERAS-404 in HIV-Negative, TB-Negative, BCG-Naive Adults
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: BCG SSI|BIOLOGICAL: Placebo|BIOLOGICAL: AERAS-404
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brexanolone to Target Concurrent PTSD and Stress Induced Alcohol Use in Veterans: A Dose Finding Study
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder (AUD)|Post Traumatic Stress Disorder (PTSD)
Interventions: DRUG: Brexanolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cognitive Behavioral Therapy (CBT) and Physical Exercise for Climacteric Symptoms in Breast Cancer Patients Experiencing Treatment-Induced Menopause: a Multicenter Randomized Trial
Status: UNKNOWN
Conditions: Menopausal Symptoms in Breast Cancer Patients With Treatment-Induced Complaints
Interventions: BEHAVIORAL: CBT and relaxation|BEHAVIORAL: Physical activity|BEHAVIORAL: CBT and physical activity|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Care and Reducing Cost Study
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Psychosis NOS
Interventions: BEHAVIORAL: Relapse Prevention Plan|BEHAVIORAL: Daily Support Website|BEHAVIORAL: Computer CBT for voices and paranoia|BEHAVIORAL: FOCUS|OTHER: Prescriber Decision Assistant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ginger Capsules for the Acute Treatment of Migraine Attacks
Status: COMPLETED
Conditions: Migraine
Interventions: DIETARY_SUPPLEMENT: Extract of ginger|OTHER: Cellulose|DRUG: Intravenous ketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT