pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trial of Bendamustine And Rituximab for Patients With Previously Untreated Extranodal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
Status: COMPLETED
Conditions: MALT LYMPHOMA
Interventions: DRUG: Rituximab and Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Pandemic Preparedness Through Airway Immunology Characterization
Status: NOT_YET_RECRUITING
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Vaxigripetra|BIOLOGICAL: Flumist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tolfenamic Acid, Gemcitabine and Radiation for Locally Advanced or Metastatic Pancreatic Cancer Requiring Radiation
Status: WITHDRAWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Tolfenamic acid + gemcitabine + radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DIrect Oral Anticoagulation and mechaNical Aortic Valve
Status: NOT_YET_RECRUITING
Conditions: Aortic Valve Disease
Interventions: DRUG: Apixaban 5 MG Oral Tablet|DRUG: warfarin with an objective of INR target of 2.5 (range: 2.0-3.0)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of the Effect of Topical Sodium Hyaluronate Immediately Post-PKP on Time to Reepithelialization
Status: COMPLETED
Conditions: Corneal Transplantation
Interventions: DRUG: sodium hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of PENG Block and FICB in Hip Fracture Patients
Status: COMPLETED
Conditions: Hip Fractures|Regional Anesthesia
Interventions: PROCEDURE: Pericapsular nerve group (PENG) block|PROCEDURE: Fascia iliaca compartment block (FICB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Prexasertib (LY2606368) With Chemotherapy or Targeted Agents in Participants With Advanced Cancer
Status: COMPLETED
Conditions: Neoplasm Metastasis|Colorectal Neoplasms|Breast Cancer
Interventions: DRUG: Prexasertib|DRUG: Cisplatin|DRUG: Cetuximab|DRUG: G-CSF|DRUG: Pemetrexed|DRUG: Fluorouracil|DRUG: LY3023414|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Zero Tolerance Program (SToP) on Child's Urine Cotinine Level According to Exposure Feedback
Status: COMPLETED
Conditions: Second Hand Smoke|Exposure to Environmental Pollution|Child|Urine|Parents
Interventions: BEHAVIORAL: Zero (0) Tolerance Program (SToP)|BEHAVIORAL: Exposure Feedback Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Inspiratory Muscles Strengthening Among Coronary Patients on the Sleep Apnea Obstructive Syndrome
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Acute Coronary Syndrome
Interventions: DEVICE: POWERbreathe Fitness Plus, (POWERbreathe International Ltd, UK) [Inspiratory muscles strengthening]|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The HIP Self-management Study
Status: RECRUITING
Conditions: GTPS - Greater Trochanteric Pain Syndrome|Gluteal Tendinopathy|Trochanteric Bursitis|Lateral Hip Pain
Interventions: OTHER: Self-management|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Brolucizumab in Neovascular Age-related Macular Degeneration With Limited Response to Aflibercept
Status: TERMINATED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: Brolucizumab 6 mg solution for intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vanguard XP and Vanguard CR Total Knee Arthroplasties. A Trial Evaluating Early Component Migration by RSA and Patient Reported Outcome.
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis
Interventions: DEVICE: Wich prosthesis is used
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Clinical Study of Adebrelimab in Combination With Decitabine, Albumin-bound Paclitaxel, and Gemcitabine for the First-line Treatment of Metastatic Pancreatic Cancer
Status: RECRUITING
Conditions: Adebrelimab (SHR-1316)|Decitabine|Metastatic Pancreatic Cancer
Interventions: DRUG: Adebrelimab;decitabine;
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EP-100 Plus Paclitaxel Versus Paclitaxel Alone in Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer Recurrent
Interventions: DRUG: EP-100|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gingival Depigmentation Using Diode Laser 940nm Versus 980nm
Status: COMPLETED
Conditions: Gingival Pigmentation
Interventions: DEVICE: Biolase Epic X 940nm wavelength Diode laser|DEVICE: Doctor smile simpler 980nm wavelength Diode laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA)
Status: NOT_YET_RECRUITING
Conditions: Immunotherapy
Interventions: DRUG: Fecal microbiota transfer|DRUG: Vancomycin Oral Capsule|DRUG: Atezolizumab + Bevacizumab|DRUG: Placebo Vancomycin Oral Capsule|DRUG: Placebo Fecal microbiota transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing KIDScore™ D5 and iDAScore®. The KiDA Study
Status: COMPLETED
Conditions: IVF|Infertility
Interventions: DEVICE: iDAScore®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Manipulation Treatment in Cervical Region
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Cervicothoracic thrust manipulation|OTHER: Cervicothoracic thrust manipulation sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia
Status: RECRUITING
Conditions: Barretts Esophagus With Dysplasia|Barrett Esophagus|Esophageal Adenocarcinoma
Interventions: PROCEDURE: Endoscopic Eradication Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Including Fitness Testing in Preventive Health Checks on Cardiorespiratory Fitness and Motivation
Status: COMPLETED
Conditions: Cardiorespiratory Fitness|Physical Activity|Health Behavior|Motivation|Intention
Interventions: BEHAVIORAL: Health checks with fitness testing|BEHAVIORAL: Health checks without fitness testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Topical Composition Therapy for the Treatment of Cutaneous Mastocytosis
Status: TERMINATED
Conditions: Cutaneous Mastocytoses
Interventions: COMBINATION_PRODUCT: Topical preparation of sodium cromolyn 5%, diphenhydramine 1% and trolamine salicylate 10% in emollient cream base.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis
Status: COMPLETED
Conditions: Nasal Congestion and Inflammations|Rhinitis
Interventions: DRUG: brompheniramine + phenylephrine|DRUG: Brompheniramine + pseudoephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock
Status: COMPLETED
Conditions: Aging|Epigenetics|Inflammatory Mediators
Interventions: DRUG: Rapamycin Topical Ointment|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aesthetic and Functional Results of Alar Base Modifications in Rhinoplasty
Status: UNKNOWN
Conditions: Rhinoplasty|Surgical Procedure, Unspecified|Surgery, Plastic|Cicatrix|Healing Scar
Interventions: PROCEDURE: Alar facial groove incision|PROCEDURE: Alar facial groove spared
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring the Impact of Cognitive and Psychosocial Interventions in Persons With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: Cognitive intervention|OTHER: Psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Venetoclax|DRUG: Azacitidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Boosting Regimen With Oral Cholera Vaccine
Status: COMPLETED
Conditions: Cholera
Interventions: BIOLOGICAL: Shanchol™, oral cholera vaccine|BIOLOGICAL: Shanchol™, killed, whole cell, bivalent, oral cholera vaccine|OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Examine Past Estimated Glomerular Filtration Rate (eGFR) Slope as a Risk Marker for Rapid Kidney Function Decline in People With Chronic Kidney Disease
Status: TERMINATED
Conditions: Chronic Kidney Disease
Interventions: DIAGNOSTIC_TEST: collection of serum/capillary creatinine values
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Alveolar Ridge Changes With Biologically Oriented Alveolar Ridge Preservation (BARP) After Tooth Extraction
Status: UNKNOWN
Conditions: Alveolar Ridge Preservation
Interventions: PROCEDURE: biologically oriented alveolar ridge preservation|PROCEDURE: xenogenic bone graft in entire (apico-coronal) extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bilateral Dispensing Study of MyDay Toric, 1-day Acuvue Moist for Astigmatism, and Dailies Aquacomfort Plus Toric Lenses
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Dailies Aquacomfort Plus Toric|DEVICE: 1-Day Acuvue Moist for Astigmatism|DEVICE: MyDay Toric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: DEXTENZA Compared to Topical Steroid Therapy Prior to Cataract Surgery in Patients Who Receive Premium Intraocular Lenses
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Dexamethasone|DRUG: Prednisolone Acetate 1% Oph Susp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery
Status: COMPLETED
Conditions: Mitral Regurgitation|Mitral Stenosis|Tricuspid Regurgitation
Interventions: PROCEDURE: Acute normovolemic hemodilution (ANH)|DRUG: hydroxyethyl starch (HES 130/0.6)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study One
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: BIOLOGICAL: Alemtuzumab|BIOLOGICAL: Interferon beta-1a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oleocanthal Rich Olive Oil Acute Effects on Hyperglycemia and Platelet Activation in T2DM
Status: UNKNOWN
Conditions: Diabetes Mellitus, Adult-Onset|Platelet Dysfunction|Postprandial Hyperglycemia|Lipidemia|Inflammation|Oxidative Stress
Interventions: OTHER: White bread|OTHER: Butter|OTHER: Refined olive oil|OTHER: EVOO with 250 mg/kg oleocanthal|OTHER: EVOO with 500 mg/kg oleocanthal|OTHER: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Effect of IM Testosterone Undecanoate on Biochemical and Anthropometric Characteristics of Metabolic Syndrome in Hypogonadal Men
Status: UNKNOWN
Conditions: Metabolic Syndrome|Hypogonadism
Interventions: DRUG: Nebido (testosterone undecanoate)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electrolysis Percutaneous Therapeutic (EPTE) for Supraspinatus Tendinopathy
Status: COMPLETED
Conditions: Supraspinatus Tendinopathy
Interventions: OTHER: Electrolysis Percutaneous Therapeutic (EPTE)|OTHER: Eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Eating Within a Limited Time on Sugar Sensitivity and Liver Sugar Stores of People With Type 2 Diabetes.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Time restricted feeding|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Test the Food for Special Medical Purpose in Perioperative Patients With Gastrointestinal Cancer
Status: RECRUITING
Conditions: Gastrointestinal Cancer
Interventions: OTHER: Nutrition Emulsion (TPF-T)|OTHER: Foods for special medical purposes [FSMP] for patients with tumors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Can Whey Protein Improve Glycemic Control in Type 2 Diabetes?
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hyperglycemia
Interventions: DIETARY_SUPPLEMENT: Whey protein|DIETARY_SUPPLEMENT: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia
Status: COMPLETED
Conditions: Oxidative Stress|Anesthesia
Interventions: DRUG: Total Intravenous Anesthesia(TIVA)|DRUG: Inhalation Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: BAY81-8973 Pediatric Safety and Efficacy Trial
Status: COMPLETED
Conditions: Haemophilia A
Interventions: BIOLOGICAL: Recombinant Factor VIII (Kovaltry, BAY81-8973)|BIOLOGICAL: Recombinant Factor VIII (Kovaltry, BAY81-8973)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Femoral Nerve Blockade and Readiness to Discharge Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Arthroplasty
Interventions: DRUG: Bolus of 0.2% ropivicaine 20 mls followed by 0.2% ropivicaine at an infusion rate of 5mls/hr until 0600 on postoperative day 2|DRUG: Bolus of 0.2% ropivicaine 20 mls followed by 0.1% ropivicaine at an infusion rate of 10mls/hr until 0600 on post-operative day 2|DRUG: Saline control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mipomersen on LDL-Cholesterol Levels in Patients Treated by Regular Apheresis
Status: COMPLETED
Conditions: Atherosclerosis|LDL-hypercholesterolemia
Interventions: DRUG: mipomersen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crohn's Allogeneic Transplant Study
Status: TERMINATED
Conditions: Crohn Disease
Interventions: PROCEDURE: Allogeneic Bone Marrow Transplantation|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|DRUG: Mycophenolic Acid|OTHER: Quality-of-Life Assessment|DRUG: Tacrolimus|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Autologous Platelet Rich Plasma in the Treatment of Chronic Non-Healing Wounds
Status: TERMINATED
Conditions: Foot Ulcer Chronic|Skin Ulcer Venous Stasis Chronic|Pressure Ulcer
Interventions: PROCEDURE: Platelet Rich Plasma|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Substrate and Trigger Ablation for Reduction of Atrial Fibrillation Trial - Star AF II Study
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: PVI + Lines ablation|PROCEDURE: PVI|PROCEDURE: PVI + CFE ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Locus Coeruleus Function in Sustained Attention
Status: RECRUITING
Conditions: Attention - no Condition is Being Assessed - Healthy Adults
Interventions: DRUG: Modafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fractional Laser and Ultrasound for Striae Distensae
Status: COMPLETED
Conditions: Stretch Marks
Interventions: DEVICE: Combination treatment|DEVICE: 1550-nm erbium-doped fractionated laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noxipoint Therapy Versus Standard Physical Therapy Using Electrical Stimulation for Chronic Pain
Status: COMPLETED
Conditions: Shoulder Pain|Neck Pain
Interventions: PROCEDURE: Noxipoint Therapy|PROCEDURE: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thailand Transgender Women Stigma Study
Status: NOT_YET_RECRUITING
Conditions: Pre-Exposure Prophylaxis
Interventions: BEHAVIORAL: Mobile Healthy Choices (mHC)|BEHAVIORAL: Finding Respect and Ending Stigma around HIV (FRESH)|BEHAVIORAL: Standard PrEP Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acquired Immunodeficiency Syndrome(AIDS) and Tuberculosis(Tb) Co-infection Treatment Strategies Study of China.
Status: UNKNOWN
Conditions: AIDS
Interventions: DRUG: INH RIF Rifb PZA EMB AZT 3TC D4T EFV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of RP1 Monotherapy and RP1 in Combination With Nivolumab
Status: RECRUITING
Conditions: Cancer|Melanoma (Skin)|Mismatch Repair Deficiency|Microsatellite Instability|Non-melanoma Skin Cancer|Cutaneous Melanoma|NSCLC
Interventions: BIOLOGICAL: RP1|BIOLOGICAL: nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Miltefosine in Cutaneous Leishmaniasis (Brazil)
Status: COMPLETED
Conditions: Treatment of Cutaneous Leishmaniasis in Brazil.
Interventions: DRUG: Miltefosine.|DRUG: Meglumine antimoniate.|DRUG: Miltefosine.|DRUG: Meglumine antimoniate.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Man Experience With a Drug Eluting Stent in De Novo Coronary Artery Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: ORSIRO - Drug Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer
Status: RECRUITING
Conditions: HR+HER2- Breast Cancer
Interventions: DRUG: BL-B01D1|DRUG: Eribulin|DRUG: Vinorelbine|DRUG: Gemcitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Supplementation With Curcumin in Patients With Proteinuric Diabetic Kidney Disease
Status: UNKNOWN
Conditions: Proteinuria
Interventions: DIETARY_SUPPLEMENT: Curcumin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Laparoendoscopic Single Site Hysterectomy in Benign and Preinvasive Uterine Disease
Status: COMPLETED
Conditions: Benign or Preinvasive Uterine Disease
Interventions: PROCEDURE: Single-port LAVH|PROCEDURE: Three-port LAVH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Oral Contraceptives During Disuse
Status: RECRUITING
Conditions: Oral Contraceptives|Rehabilitation|Menstrual Cycle|Physical Therapy
Interventions: OTHER: Wrist/hand immobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomised Trial of 3 Artemisinin Combination Therapy for Malaria in Pregnancy
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: dihydroartemisinin-piperaquine|DRUG: Artesunate-mefloquine|DRUG: arthemeter-lumefantrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TBTC Study 23A: Pharmacokinetics of Intermittent Isoniazid and Rifabutin in HIV-TB
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Isoniazid|DRUG: Rifabutin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral Administration of SAR441000 as Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Metastatic Neoplasm
Interventions: DRUG: SAR441000|DRUG: Cemiplimab REGN2810
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of 5-Aminolevulinic Acid on Iron Deficiency Anemia
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Iron alone|DIETARY_SUPPLEMENT: Low-dose 5-aminolevulinic acid with iron|DIETARY_SUPPLEMENT: Medium-dose 5-aminolevulinic acid with iron|DIETARY_SUPPLEMENT: High-dose 5-aminolevulinic acid with iron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial to Compare Efficacy and Tolerability of Fulvestrant 250mg, 250mg (Plus 250mg Loading Regimen) and 500mg
Status: COMPLETED
Conditions: Advanced Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study of GNR-051 in Subjects With Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Renal Cell|Melanoma
Interventions: BIOLOGICAL: GNR-051
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NaF Positron Emission Tomography/Computed Tomography (PET/CT)Imaging to Assess Treatment Responsiveness to TAK-700 in Patients With Castrate Resistant Prostate Cancer (CRPC) With Bone Metastasis
Status: TERMINATED
Conditions: Prostatic Neoplasms|Prostate Cancer
Interventions: DRUG: TAK-700|RADIATION: Fluorine F 18 Sodium Fluoride|PROCEDURE: Positron Emission Tomography|PROCEDURE: Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Train-of-Four Recovery in the Adductor Pollicis Versus the Adductor Digiti Minimi in Elective Surgery Patients
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Neuromuscular Blockade
Interventions: DEVICE: EMG Assessement of Recovery of Neuromuscular Function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Mircera in Anemic Patients With Chronic Kidney Disease Not Yet on Dialysis.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of a Single Dose of AVI-4126 (RESTEN-NG®) in Cerebral Spinal Fluid
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: AVI-4126 Injection (RESTEN-NG®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Diclofenac vs. Nepafenac Ophthalmic Drops: Patient Comfort
Status: UNKNOWN
Conditions: Post Surgical Management|Pain Management|Inflamation Management
Interventions: DRUG: Diclofenac|DRUG: Nepafenac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Compassionate Communication and Advance Care Planning to Improve End of Life Care in Treatment of Hematological Disease (ACT)
Status: RECRUITING
Conditions: Multiple Myeloma|Myelodysplastic Syndromes|Lymphoma|Acute Myeloid Leukemia
Interventions: BEHAVIORAL: Advance consultation concerning your life and treatment (ACT )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Probiotic on Type 2 Diabetes and Chronic Obstruction Pulmonary Disease
Status: RECRUITING
Conditions: Type 2 Diabetes|Chronic Obstructive Pulmonary Disease
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: L. salivarius AP-32 and L. reuteri GL-104|DIETARY_SUPPLEMENT: L. reuteri GL-104
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)(Recov)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant two-component COVID-19 vaccine (CHO cell)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Evaluation of Safety and Myopia Progression Control Using Novel Spectacle Lens
Status: ACTIVE_NOT_RECRUITING
Conditions: Myopia
Interventions: DEVICE: Model-A Novel spectacle lens|DEVICE: Model-B Novel spectacle lens|DEVICE: Single vision spectacle lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identifying Oxytocin Deficiency in Adults With Pituitary Disease
Status: NOT_YET_RECRUITING
Conditions: Arginine Vasopressin Deficiency|Oxytocin Deficiency
Interventions: DRUG: Norethindrone Acetate-Ethinyl Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparative Safety and Efficacy of Vaginal Misoprostol Versus Lidocaine-prilocaine Cream in Levonorgestrel IUD Insertion
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: vaginal misoprostol|DRUG: Lidocaine-Prilocaine Topical cream|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis
Status: COMPLETED
Conditions: Uveitis
Interventions: DRUG: B27PD|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NT0102 in the Treatment of Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: NT0102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lead Migration During the Spinal Cord Stimulation Trial Period and Therapeutic Response
Status: RECRUITING
Conditions: Spinal Cord Stimulator Trial Period, Neuromodulation Trial Period, SCS Trial Period
Interventions: PROCEDURE: external securement of scs leads during the scs trial period
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Study of Collaborative Assessment and Management of Suicidality With Suicidal Children ("CAMS-4Kids")
Status: TERMINATED
Conditions: Suicidal Ideation|Suicide, Attempted
Interventions: BEHAVIORAL: CAMS-4Kids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect of Intra Articular Steroid Injection and Pericapsular Nerve Group Block for Hip Osteoarthritis
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: PROCEDURE: intraarticular injection|PROCEDURE: peng block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Safety Evaluation of Pneumococcal Vaccines Among Children and Elderly Adults.
Status: UNKNOWN
Conditions: Pneumococcal Vaccine Adverse Reaction
Interventions: BIOLOGICAL: 10 or 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: 23-valent pneumococcal polysaccharide vaccine|BIOLOGICAL: Influenza vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity & Safety Study of GSK Biologicals' Combined Measles-mumps-rubella-varicella Vaccine 208136
Status: COMPLETED
Conditions: Measles|Varicella|Mumps|Rubella
Interventions: BIOLOGICAL: PriorixTM|BIOLOGICAL: VarilrixTM|BIOLOGICAL: Priorix-Tetra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Improve Dynamic Lateral Balance of Humans With SCI
Status: RECRUITING
Conditions: Spinal Cord Injury
Interventions: DEVICE: robotic training|DEVICE: spinal cord electrical stimulation|DEVICE: treadmill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Safety, Immunogenicity and Efficacy of a Trivalent Rotavirus P2-VP8 Subunit Vaccine in Prevention of Severe Rotavirus Gastroenteritis in Healthy Infants in Africa and India
Status: RECRUITING
Conditions: Rotavirus Infection of Children
Interventions: BIOLOGICAL: TV P2-VP8|BIOLOGICAL: Rotarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Financial Abilities in Neurological Diseases. Development of a Telerehabilitation Program: FINAGE
Status: RECRUITING
Conditions: Parkinson Disease|Mild Cognitive Impairment|Stroke
Interventions: BEHAVIORAL: Telerehabilitation group|BEHAVIORAL: Conventioanl treatment group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CD19 CAR T-cell Target Relapsed/Refractory Acute B Cell Leukemia/Lymphoma
Status: WITHDRAWN
Conditions: B-cell Acute Lymphoblastic Leukemia|B-Cell Lymphoma, Unspecified
Interventions: BIOLOGICAL: CD19 CAR T-Cell(CAT19T2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Phase II Study of Pembrolizumab And Carboplatin Plus Docetaxel in Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple-negative Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Docetaxel|DRUG: Pembrolizumab|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genomic Investigation of Cardiovascular Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Myocardial Infarction|Atrial Fibrillation|Aortic Stenosis|Mitral Regurgitation|Idiopathic Cardiomyopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prognostic Markers of Inflammation in Infants Undergoing Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Congenital Heart Defect|Cardiopulmonary Bypass|Inflammatory Response|Low Cardiac Output Syndrome|Inflammation
Interventions: PROCEDURE: Single blood draw|PROCEDURE: Multiple blood draws|PROCEDURE: Multiple blood draws
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laser Acupuncture Improves Constipation in Patients Hospitalized for Stroke During the COVID-19 Pandemic
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DEVICE: Laser acupoint stimulation(Laser pen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: LUX Lung 2 Phase II Single Arm BIBW 2992 "Afatinib" in NSCLC With EGFR Activating Mutations
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: BIBW 2992
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Aldesleukin|DRUG: ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety of Duloxetine and Placebo for the Treatment of Depression in Elderly Patients
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: duloxetine hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas
Status: RECRUITING
Conditions: High Grade Glioma
Interventions: PROCEDURE: LITT|RADIATION: Radiation therapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of a Dose-dependent Effect of GOS on Iron Absorption, and Addition of Vitamin C
Status: COMPLETED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: ferrous fumarate|DIETARY_SUPPLEMENT: ferrous sulphate|DIETARY_SUPPLEMENT: ferric pyrophosphate|DIETARY_SUPPLEMENT: ferrous fumarate + 3.5 g GOS|DIETARY_SUPPLEMENT: ferrous fumarate + 7 g GOS|DIETARY_SUPPLEMENT: ferrous sulphate + 15 g GOS|DIETARY_SUPPLEMENT: ferrous fumarate + Vitamin C|DIETARY_SUPPLEMENT: ferric pyrophosphate + 15 g GOS|DIETARY_SUPPLEMENT: ferrous fumarate + 7 g GOS + Vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis
Status: UNKNOWN
Conditions: Chronic Diarrhoea|Lymphocytic Colitis|Collagenous Colitis
Interventions: PROCEDURE: Colonoscopy with Indigo-Carmine Chromoendoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Kinematics in Posterior Cruciate Retaining and Bi-Cruciate Retaining Total Knee Replacements
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Osteoarthritis, Knee
Interventions: DEVICE: Journey II posterior cruciate retaining total knee arthroplasty|DEVICE: Journey II posterior bi-cruciate retaining total knee arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Post Operative Pain Control for Distal Radius Surgery: Does Exparel Injected at the Surgery Site Improve Postoperative Pain Scores at 24 and 48 Hours ?
Status: WITHDRAWN
Conditions: Post Operative Pain
Interventions: DRUG: Group A (Exparel plus supraclavicular block)|DRUG: Group B (Bupivacaine HCL plus supraclavicular block)|DRUG: Group C(supraclavicular block only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MK0431 Monotherapy Study in Patients With Type 2 Diabetes Mellitus (0431-040)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin phosphate|DRUG: Comparator: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies
Status: COMPLETED
Conditions: Systemic Juvenile Idiopathic Arthritis|Hereditary Periodic Fevers
Interventions: DRUG: canakinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: St. Jude Medical Percutaneous Mitral Valve Repair Study
Status: COMPLETED
Conditions: Mitral Valve Prolapse
Interventions: DEVICE: PMVr procedure (SJM Percutaneous Mitral Valve Repair (PMVr)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study in Healthy Volunteers to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD4017 After Repeated Ascending Oral Doses
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: AZD4017|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Placebo-controlled Trial of Daliresp on Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: roflumilast|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Maraviroc (UK-427,857) in Combination With Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of Antiretroviral-Experienced NonCCR5-Tropic HIV-1 Infected Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Optimized Background Therapy (OBT)|DRUG: maraviroc (UK-427,857)|DRUG: Optimized Background Therapy (OBT)|DRUG: maraviroc (UK-427,857)|DRUG: Optimized Background Therapy (OBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Four Drug Regimens for the Prevention of Malaria in Senegalese Children
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Pyrimethamine/sulfadoxine|DRUG: Amodiaquine|DRUG: Artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: BI 836826 Dose Escalation in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL)
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: BI 836826
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2
Status: COMPLETED
Conditions: Malaria,Falciparum|Gametocytes|Controlled Human Malaria Infection|Transmission
Interventions: DRUG: Piperaquine (low dose)|DRUG: Piperaquine (high dose)|DRUG: Sulfadoxine pyrimethamine|DRUG: Atovaquone Proguanil|OTHER: malaria challenge infection, P. falciparum 3D7|OTHER: Blood stage malaria challenge infection, P. falciparum 3D7
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Effect of Food on the Pharmacokinetics of Sotagliflozin and to Explore the Relative Bioavailability in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Sotagliflozin (SAR439954)|DRUG: Sotagliflozin (SAR439954)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Metabolic Profile of Vyvanse for the Treatment of ADHD in Euthymic Adults With Bipolar I/II Disorder
Status: COMPLETED
Conditions: Attention Deficit/Hyperactivity Disorder|Bipolar Disorder
Interventions: DRUG: lisdexamfetamine dimesylate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of a Parental Training Programme to Enhance Parent-child Relationship and Reduce Harsh Parenting Practices and Parental Stress in the Preparation of Children for Transition to Primary School
Status: COMPLETED
Conditions: Parent
Interventions: BEHAVIORAL: parental training programme|BEHAVIORAL: Placebo Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CATIE-Alzheimer's Disease Trial
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Olanzapine|DRUG: Quetiapine|DRUG: Risperidone|DRUG: Citalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cryoablation Versus Radiofrequency Ablation for Small Renal Masses
Status: WITHDRAWN
Conditions: Renal Cancers
Interventions: PROCEDURE: Cryoablation|PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of 20vPnC When Coadministered With a Booster Dose of BNT162b2
Status: COMPLETED
Conditions: Pneumococcal Disease|COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: 20-valent pneumococcal conjugate vaccine (20vPnC)|BIOLOGICAL: BNT162b2|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density
Status: COMPLETED
Conditions: Osteopenia
Interventions: DRUG: Placebo|DRUG: AMG 167
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Respiratory Syncytial Virus/Human Metapneumovirus Vaccine Candidate
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Virus Infection|Healthy Volunteers|Human Metapneumovirus
Interventions: BIOLOGICAL: RSV/hMPV vaccine candidate Dose L|BIOLOGICAL: RSV/hMPV vaccine candidate Dose A|BIOLOGICAL: RSV/hMPV vaccine candidate Dose B|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION