pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Combination Chemotherapy Plus Panitumumab or Bevacizumab for Inoperable Cholangiocarcinoma Without KRAS Mutations
Status: COMPLETED
Conditions: Cholangiocarcinoma
Interventions: DRUG: Gemcitabine|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Panitumumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Study the Effects of Pulmonary Rehabilitation Program on Exercise Capacity and Quality of Life in Patients With Severe Form of Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Rehabilitation
Interventions: OTHER: Pulmonary Rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Upadacitinib|DRUG: Placebo for Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MRI Screening for Brain Metastases Among Patients With Triple Negative or HER2+ Stage II or III Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Brain imaging|DIAGNOSTIC_TEST: Analysis of circulating tumor DNA|BEHAVIORAL: Testing Morbidities Index
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Pre Pectoral Implant for Immediate Breast Reconstruction Using Single Port Endoscopy in Prophylactic Indication
Status: RECRUITING
Conditions: Genetic Predisposition|Breast Cancer
Interventions: PROCEDURE: Prophylactic mastectomy with immediate breast reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Empagliflozin vs Dapagliflozin Over Pulse Wave Velocity in Type Two Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus Type 2 Without Complication
Interventions: DRUG: Dapagliflozin 10Mg Tab|DRUG: Empagliflozin 25 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, and Immunogenicity of Two Formulations of V114 in Healthy Adults 50 Years of Age or Older (V114-006)
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: V114-A|BIOLOGICAL: V114-B|BIOLOGICAL: Prevnar 13®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Advanced Immunological Approach in COPD Exacerbation
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Ismigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Virtual Course to Increase Knowledge in Sexual Harassment,Prevention and Sanction Policies of a University
Status: COMPLETED
Conditions: Sexual Harassment
Interventions: OTHER: Face-to-face Class|OTHER: Asynchronous Virtual Class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT)
Status: RECRUITING
Conditions: Leukemia
Interventions: DRUG: Pirtobrutinib|DRUG: Obinutuzumab|DRUG: Venetoclax|DRUG: Valacyclovir|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Supplement Compliance Study
Status: COMPLETED
Conditions: Undernutrition
Interventions: DIETARY_SUPPLEMENT: Standard Oral Nutritional Supplement (ONS)|DIETARY_SUPPLEMENT: High energy Oral Nutritional Supplement (ONS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Universal Stylet Bougie in Patients With Cervical Neck Immobilization.
Status: COMPLETED
Conditions: Universal Stylet Bougie
Interventions: DEVICE: USB as a stylet|DEVICE: USB as a bougie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Neutral Versus Liberal fLuId In Traumatic Brain Injury: a Randomised Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Traumatic Brain Injury|Fluid Overload|Outcome, Fatal
Interventions: PROCEDURE: fluid balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-time fMRI Neurofeedback in Patients With Schizophrenia and Auditory Hallucinations
Status: RECRUITING
Conditions: Schizophrenia|Auditory Hallucination|Treatment-resistant Schizophrenia
Interventions: OTHER: stg-rt-fMRI-Neurofeeback|OTHER: sham-rt-fMRI-Neurofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Management in Overweight Endometrial Cancer Patients Undergoing Fertility-sparing Treatment
Status: RECRUITING
Conditions: Endometrium Cancer
Interventions: BEHAVIORAL: Weight management--diet|BEHAVIORAL: Weight management--exercise|BEHAVIORAL: Weight management--accompany|BEHAVIORAL: Weight management--refresh|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MyPADMGT Support of Out-Patients With Peripheral Arterial Disease
Status: TERMINATED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: MyPADMGT|DEVICE: MyPADMGT + Nudging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nutrition as a Determinant of Labor Outcome
Status: COMPLETED
Conditions: Labor, Obstetric
Interventions: DIETARY_SUPPLEMENT: Energy-containing soft drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Patient Satisfaction and Safety With Propofol Based Sedation With or Without Fentanyl for Gastrointestinal Endoscopy
Status: UNKNOWN
Conditions: Patient Satisfaction
Interventions: DRUG: 50-200mg propofol|DRUG: 50ug fentanyl|DRUG: 1 mg midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Sulfur Thermal Water on Circulating H2S Levels and Markers of Bone Metabolism in Osteopenic Subjects.
Status: COMPLETED
Conditions: Hydrogen Sulfide|Osteoporosis
Interventions: OTHER: inhalatory treatment with sulfureous aerosol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PACIFIC: Primary Mediastinal Large B-cell Lymphoma Treated With Antibody Therapy, Checkpoint Inhibitor in Frontline With ImmunoChemotherapy
Status: RECRUITING
Conditions: Ann Arbor Stage I Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Ann Arbor Stage II Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Ann Arbor Stage III Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Ann Arbor Stage IV Primary Mediastinal (Thymic) Large B-Cell Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Cyclophosphamide|DRUG: Doxorubicin|BIOLOGICAL: Nivolumab|DRUG: Prednisone|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Pharmacokinetics Study of Inhaled Laninamivir Octanoate TwinCaps® Dry Powder Inhaler in Children With Influenza
Status: TERMINATED
Conditions: Influenza
Interventions: DRUG: 20 mg laninamivir octanoate|DRUG: Placebo|DRUG: 40 mg laninamivir octanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 124I-FIAU Imaging in EBV and KSHV Associated Cancers
Status: COMPLETED
Conditions: Hodgkin Lymphoma|Non Hodgkin Lymphoma|Kaposi's Sarcoma|Gastric Cancer|Nasopharyngeal Cancer
Interventions: OTHER: FIAU-PET-CT-2|OTHER: FIAU-PET-CT-4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Clinical Trial to Compare the Treatment of Mild Acute Diverticulitis With or Without Antibiotics
Status: COMPLETED
Conditions: Acute Diverticulitis
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen|DRUG: Amoxicillin/clavulanic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-Thrombotic Strategy After Trans-Aortic Valve Implantation for Aortic Stenosis
Status: COMPLETED
Conditions: Symptomatic Aortic Stenosis|Eligible for Transcatheter Aortic Valve Replacement
Interventions: DRUG: Apixaban|DRUG: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of STS101 in the Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine|Migraine With Aura|Migraine Without Aura
Interventions: DRUG: Dihydroergotamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury
Status: NOT_YET_RECRUITING
Conditions: Disorders of Consciousness|Acquired Brain Injury
Interventions: DIAGNOSTIC_TEST: EEG-EOG recording at rest and during an auditory oddball paradigm
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Breathing Training on Psychosocial Functioning and Heart Rate Variability in Postmenopausal Women With Depressive Symptoms-2
Status: WITHDRAWN
Conditions: Postmenopause
Interventions: BEHAVIORAL: Breathing training|BEHAVIORAL: Stress management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravascular Lithotripsy in Comparison to Rotational Atherectomy: An Evaluation by OFDI
Status: RECRUITING
Conditions: Intravascular Lithotripsy; Rotational Atherectomy; OFDI
Interventions: DEVICE: Intravascular Lithotripsy|DEVICE: Rotational Atherectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone
Status: COMPLETED
Conditions: Coronary Artery Disease|Valvular Heart Disease
Interventions: DRUG: etomidate|DRUG: thiopentone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Perceptual Learning Based Digital Therapeutics for Visual Field Defect After Stroke
Status: COMPLETED
Conditions: Visual Fields Hemianopsia|Hemianopsia, Homonymous
Interventions: DEVICE: VIVID Brain|OTHER: No-treatment Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Insight Enhancement Program vs. Metacognitive Training for Psychosis in Patients With Schizophrenia: A Three-Armed Comparative Randomized Controlled Trial
Status: COMPLETED
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders
Interventions: BEHAVIORAL: Insight Enhancement Program (IEP)|BEHAVIORAL: Metacognitive Training for Psychosis (MCT)|DRUG: Treatment As Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin and Sympathetic Nerve Traffic
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Empagliflozin|DRUG: Hydrochlorothiazide 25 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions
Status: COMPLETED
Conditions: Endocrine System Diseases
Interventions: DIETARY_SUPPLEMENT: 1.56 g L-Tryptophan|DIETARY_SUPPLEMENT: 1.56 g L-Leucine|DIETARY_SUPPLEMENT: 50 g Xylitol|DIETARY_SUPPLEMENT: 75 g Erythritol|DIETARY_SUPPLEMENT: 75 g Glucose|DIETARY_SUPPLEMENT: Tap water|DIETARY_SUPPLEMENT: Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)|DEVICE: Nasogastric Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia Patients
Status: UNKNOWN
Conditions: Schizophrenia|Metabolic Syndrome|Berberine|Metformin
Interventions: DRUG: Berberine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protecting Preterm Infants From Respiratory Tract Infections and Wheeze by Using Bacterial Lysates.
Status: RECRUITING
Conditions: Wheezing|LRTI|Premature
Interventions: DRUG: Broncho-Vaxom|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Impact of Climate Environment in Different Latitudes on the Occurrence of PICC Complications
Status: NOT_YET_RECRUITING
Conditions: Cancer|Thrombus|Phlebitis|Infections
Interventions: DEVICE: tunneled PICC|DEVICE: routine PICC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study
Status: TERMINATED
Conditions: Acute Lymphoblastic Leukemia|Leukemia, Acute Myeloid (AML), Child|Lymphoma, Non-Hodgkin|Myelodysplastic Syndromes|Primary Immunodeficiency|Anemia, Aplastic|Hemoglobinopathies|Cytopenia|Fanconi Anemia|Diamond Blackfan Anemia|Thalassemia|Anemia, Sickle Cell
Interventions: DRUG: Rimiducid|BIOLOGICAL: rivogenlecleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Shenwu Capsule
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Shenwu Capsule|DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children
Status: COMPLETED
Conditions: Meningitis|Meningococcemia
Interventions: BIOLOGICAL: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate|BIOLOGICAL: Haemophilus Influenzae Type b (Hib) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Validation of the PsASon ULtrasound Scores in Patients With Psoriatic Arthritis Undergoing TReatment With Apremilast
Status: WITHDRAWN
Conditions: Psoriatic Arthritis
Interventions: DRUG: Apremilast
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Online Group Therapy for Mothers of Babies With Congenital Heart Disease
Status: RECRUITING
Conditions: Depressive Symptoms|Anxiety State|Psychological Well-Being
Interventions: OTHER: Online group therapy|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bougie Sleeve Trial
Status: NOT_YET_RECRUITING
Conditions: Morbid Obesity
Interventions: PROCEDURE: Laparoscopic sleeve gastrectomy using 48-Fr bougie|PROCEDURE: Laparoscopic sleeve gastrectomy using standard care bougie
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Volunteers and Patients With Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: GSK2831781|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Atomoxetine for Attention Deficit and Hyperactive/Impulsive Behaviour Problems in Children With ASD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate the Safety and Immunogenicity of Low Dose Flu Vaccines
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Flu Vaccine (FLUARIX®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of 2X-121 in Patients With Advanced Ovarian Cancer Selected by the 2X-121 DRP®
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Ovarian Cancer
Interventions: DRUG: 2X-121|DEVICE: 2X-121 DRP®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intestinal Mesenchymal Stem Stells and Inflammatory Bowel Diseases
Status: TERMINATED
Conditions: Inflammatory Bowel Diseases
Interventions: OTHER: Intestinal biopsies during colonoscopy|OTHER: Biopsies taken on surgical specimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic Dysfunction
Status: COMPLETED
Conditions: Hypertension|Diastolic Dysfunction
Interventions: DRUG: valsartan|DRUG: amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Colchicine Tablets in Patients With COVID-19
Status: UNKNOWN
Conditions: Covid19|Colchicine
Interventions: DRUG: Colchicine Tablets|DRUG: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Posterior Component Separation Modified TAR Technique "Transversus Abdominids Release" in the Treatment of Parastomal Hernia
Status: UNKNOWN
Conditions: TAR Technique
Interventions: PROCEDURE: posterior component separation modified TAR technique "Transversus Abdominids Release"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Statin Holiday in Dialysis Patients Over 70 Years Old on Mental Function, Physical Function and Frailty
Status: UNKNOWN
Conditions: ESRD|Cardiovascular Diseases
Interventions: DRUG: discontinue statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Trial of Vit D and Calcium for Recurrent BPPV
Status: NOT_YET_RECRUITING
Conditions: BPPV|Benign Paroxysmal Positional Vertigo|Vertigo|Vertigo, Peripheral|Dizziness|Dizziness; Epidemic|Vitamin D Deficiency|Calcium Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D +/- calcium|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Ropinirole Immediate Release With Ropinirole Prolonged Release in Patients With Advanced Parkinson's
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Ropinirole prolonged release|DRUG: ropinirole immediate release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Cerebral Changes Following CTS Treated With Guided Plasticity
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: OTHER: EMLA® adjuvant|BEHAVIORAL: Sensory training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Effect on Nitrogen Retention of Two Different Posology Schemes of PKU GOLIKE PLUS 3-16 and Free AAs in Patients With Phenylketonuria
Status: TERMINATED
Conditions: Phenylketonurias
Interventions: OTHER: GOLIKE PLUS 3-16|OTHER: Free AAs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cost Effectiveness and Evaluation of Disease Management of Chronic Kidney Disease and High Risk Population
Status: UNKNOWN
Conditions: Chronic Kidney Diseases|Chronic Kidney Insufficiency
Interventions: BEHAVIORAL: general management|BEHAVIORAL: self-management|BEHAVIORAL: peer-assisted management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lateral Prostate Capsule Sparing Versus Nerve Sparing Robot-assisted Radical Cystectomy-orthotopic Ileal Neobladder for Bladder Cancer in the Male
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: PROCEDURE: lateral prostate capsule sparing or neurovascular bundles sparing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hypothermia Rewarming With Distal Limb Warming
Status: COMPLETED
Conditions: Rewarming by Shivering Heat Production Only|Rewarming by Arm and Leg Immersion in Warm Water|Rewarming by Arm and Leg Exposure to Fluidotherapy
Interventions: DEVICE: Fluidotherapy warming device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasted Bioequivalence Study of Clopidogrel Film-coated Tablets, 75 mg in 48 Healthy, Adult Male and Female Subjects.
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Сlopidogrel bisulfate film-coated tablets, 75 mg (JSC Farmak, Ukraine)|DRUG: Plavix® 75 mg film-coated tablets (Sanofi Winthrop Industrie, France)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: BV After Allogeneic Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin (Bv)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Per-partum Fetal Hypoxia: Measure of Placental Elasticity and Viscosity During Labor
Status: UNKNOWN
Conditions: Placental Elastography|Fetal Monitoring
Interventions: OTHER: Sonographic measure of placental elasticity and viscosity
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Investigating the Absolute Oral Bioavailability of Balovaptan After Single and Multiple Daily Oral Doses of Balovaptan in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Oral Balovaptan|DRUG: IV Balovaptan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Therapy Based of Tumoral mRNA Levels of ERCC1, RRM1 and BRCA1 in Advanced Non-Small-Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Docetaxel|DRUG: Cisplatin|DRUG: Vinorelbine|DRUG: Pemetrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
Status: RECRUITING
Conditions: Primary Open Angle Glaucoma|Open Angle Glaucoma
Interventions: DEVICE: Minimally Invasive Micro Sclerostomy Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Canada Lymph Node Score: A Feasibility Randomized Controlled Trial
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DIAGNOSTIC_TEST: Selective Targeted Sampling|DIAGNOSTIC_TEST: Systematic Sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of Four Candidate Influenza Vaccines to Prevent Influenza Disease in the Elderly Population
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluarix|BIOLOGICAL: Fluarix-AS25|BIOLOGICAL: Fluarix-AS50|BIOLOGICAL: Fluarix-AS01B|BIOLOGICAL: Fluarix-AS01E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of 200 Mcg of gp120 (CHO) BIOCINE in MF59 Emulsion Versus the Emulsion Control: Three Injections at 0, 1, and 6 Months
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: rgp120/HIV-1 SF-2
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: Randomized Controlled Trial of Digital Twin Precision Treatment: A Novel Whole Body Digital Twin Enabled Precision Treatment for Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Twin Precision Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EMAehealth Web Tool for Pregnancy and Puerperium: Effectiveness
Status: UNKNOWN
Conditions: Pregnant Women|Postpartum Period
Interventions: OTHER: EMAeHealth digital tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PLZ4-Coated Paclitaxel-Loaded Micelles for the Treatment of Patients With Recurrent or Refractory Non-Muscle Invasive Bladder Cancer
Status: RECRUITING
Conditions: Recurrent Non-Muscle Invasive Bladder Carcinoma|Stage 0a Bladder Cancer AJCC v8|Stage 0is Bladder Cancer AJCC v8|Stage I Bladder Cancer AJCC v8
Interventions: DRUG: PLZ4-coated paclitaxel loaded micelles (PPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals
Status: UNKNOWN
Conditions: Hydroxychloroquine|Antimalarials|Enzyme Inhibitors|Antirheumatic Agents
Interventions: DRUG: Hydroxychloroquine Sulfate|DRUG: Bromhexine 8 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study of a New Chemotherapy Agent to Treat Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms|Breast Cancer, Metastatic
Interventions: DRUG: Sagopilone (BAY86-5302, ZK 219477)|DRUG: Sagopilone (BAY86-5302, ZK 219477)|DRUG: Sagopilone (BAY86-5302, ZK 219477)|DRUG: Sagopilone (BAY86-5302, ZK 219477)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability Study of Long-acting Cabotegravir Plus Long-acting Rilpivirine (CAB LA + RPV LA) in Human-immunodeficiency Virus-1 (HIV-1) Infected Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: Cabotegravir Tablets|DRUG: Rilpivirine Tablets|DRUG: Cabotegravir Injectable Suspension|DRUG: Rilpivirine Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Clinical Application of Horticulture Therapy in Psychiatric Rehabilitation
Status: UNKNOWN
Conditions: Horticulture Therapy in Psychiatric Rehabilitation
Interventions: BEHAVIORAL: Horticulture Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Study of Sharkskin Versus Grieshaber Forceps During ILM Peeling
Status: UNKNOWN
Conditions: Epiretinal Membrane|Macular Holes
Interventions: DEVICE: Sharkskin|DEVICE: Grieshaber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing the Feasibility of Integrating Maternal Nutrition Interventions Into an Existing MNCH Platform in Bangladesh
Status: COMPLETED
Conditions: Poor Fetal Growth|Small-for-gestational Age|Premature Birth
Interventions: BEHAVIORAL: Maternal Nutrition Behavior change
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gemcitabine and Camrelizumab Plus Apatinib Versus Cisplatin in First-line Treatment of RM-NPC
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management
Status: COMPLETED
Conditions: Marijuana Dependence
Interventions: BEHAVIORAL: Standard CBT|BEHAVIORAL: CBT+CM/adherence|BEHAVIORAL: CM/abstinence|BEHAVIORAL: CM/abstinence+CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer
Status: COMPLETED
Conditions: Anemia|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System.
Status: RECRUITING
Conditions: Epilepsy|Seizures
Interventions: DEVICE: Epitel's™ Remote EEG Monitoring System's (REMI™)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness and Safety of Mitral Valve Repair With the NeoChord DS1000 Artificial Chordae Delivery System Versus Conventional Surgery in Patients With Severe Primary Mitral Regurgitation Due to Isolated Leaflet Prolapse
Status: WITHDRAWN
Conditions: Cardiovascular Diseases
Interventions: DEVICE: NeoChord beating heart mitral valve implantation|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML
Status: RECRUITING
Conditions: Leukemia, Myeloid, Acute
Interventions: BIOLOGICAL: CD33KO-HSPC; CART33
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy of Dapagliflozin + Metformin XR Versus Metformin XR in Participants With HR+, HER2-, Advanced Breast Cancer While on Treatment With Alpelisib and Fulvestrant
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Alpelisib|DRUG: Fulvestrant|DRUG: Metformin XR|DRUG: Dapagliflozin + metformin XR|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunological Tolerance in Patients With Mismatched Kidney Transplants
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Kidney Disease|Immunological Tolerance|Kidney Transplant Failure and Rejection|Chronic Kidney Diseases
Interventions: COMBINATION_PRODUCT: Donor CD34+, CD3+. and belumosudil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study to Compare CyberKnife to Surgical Resection In Stage I Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: CyberKnife Stereotactic Radiotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy Combined Camrelizumab in Patients With Advanced/Metastatic Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Combinational Immunotherapy|Hepatocellular Carcinoma Non-Resectable|Hyperbaric Oxygen Therapy
Interventions: COMBINATION_PRODUCT: hyperbaric oxygen therapy plus Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoration of Physical Function in Patients Following Total Knee Replacement: Comparison Between Resistive Strength Training Exercises & Ankle Weights
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Resistance exercises|OTHER: Ankle weights
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study Comparing Urolift and TURP Ahead of Radiotherapy in Men With Urinary Symptoms Secondary to Prostate Enlargement
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: TURP|PROCEDURE: UroLift
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Conventional Hemodialysis Vs Short Daily Hemodialysis for Patients Coming From Peritoneal Dialysis (HAPD/CAPD)
Status: UNKNOWN
Conditions: End Stage Renal Disease
Interventions: PROCEDURE: Short daily hemodialysis|PROCEDURE: Conventional hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Annual Study to Investigate Inactivated Subunit Influenza Vaccine Due to New Virus Strains for the 2012/2013 Season
Status: COMPLETED
Conditions: Prophylaxis of Influenza
Interventions: BIOLOGICAL: Trivalent influenza subunit vaccine Influvac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Multiple Myeloma
Interventions: DRUG: PI3K-beta Inhibitor GSK2636771
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Quadrivalent Influenza Virus Split Vaccine (MDCK Cells) for Individuals Aged 6 Months and Above.
Status: RECRUITING
Conditions: Influenza
Interventions: BIOLOGICAL: Quadrivalent influenza virus split vaccine (MDCK cells)|BIOLOGICAL: Quadrivalent influenza virus split vaccine (Chicken embryo)|OTHER: Phosphate buffer solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain
Status: RECRUITING
Conditions: Chronic Pain|Neck Pain|Back Pain
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Acceptance and Commitment Therapy|BEHAVIORAL: Emotional Awareness and Expression Therapy|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicentre, Single-arm, Open-label Safety Study of Lenalidomide Plus Dexamethasone in Previously Treated Subjects With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Integration Success and Maintenance of Short Implants in Maxillas Needing Sinus Augmentation
Status: COMPLETED
Conditions: Tooth Disease|Partial Edentulism
Interventions: DEVICE: Dental Implant (Nanotite)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants With Schizophrenia
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: KarXT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of rFVIIIFc Manufactured at 15,000 L (15K) Scale
Status: COMPLETED
Conditions: Severe Hemophilia A
Interventions: BIOLOGICAL: rFVIIIFc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cisplatin, Etoposide and PI3K Inhibitor BKM120 in Treating Patients With Advanced Solid Tumors or Small Cell Lung Cancer
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: BKM120|DRUG: cisplatin|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ixabepilone Administered as an Enteric Coated Formulation.
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Ixabepilone|DRUG: Ixabepilone|DRUG: Ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic (PD) Profiles of 3 Doses of Fluticasone Furoate (FF)/GW642444 Inhalation Powder at the End of a 28-day Treatment Period in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Compared to Placebo
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Furoate (FF)/GW642444 Inhalation Powder|DEVICE: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Median and Paramedian Anesthesia in Cesarean Section
Status: UNKNOWN
Conditions: Anesthesia
Interventions: PROCEDURE: median anesthesia|PROCEDURE: paramedian anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: DRUG: bupivacaine liposome suspension|DRUG: concentrated multi drug Ketorlac, Morphine PF, Epinephrine, Ropivicaine, 0.9% NaCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults
Status: COMPLETED
Conditions: Pain Dysfunction|Sleep Disturbance|Osteoarthritis
Interventions: BEHAVIORAL: Lifestyles A|BEHAVIORAL: Lifestyles B|BEHAVIORAL: Lifestyles C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE)
Status: COMPLETED
Conditions: Atherosclerotic Cardiovascular Disease
Interventions: DRUG: Inclisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant FIRINOX for Borderline Resectable Pancreatic Cancer - a Pilot Study
Status: COMPLETED
Conditions: Patients With Borderline Resectable Pancreatic Cancer
Interventions: DRUG: FIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of 5-Aminolevulinic Acid to Assess Bone and Tissue Profusion in Orthopaedic Infection Patients
Status: WITHDRAWN
Conditions: Trauma|Infection|Bone Fracture
Interventions: PROCEDURE: Imaging using 5-Aminolevulinic Acid (5-ALA) during surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 Infection
Status: COMPLETED
Conditions: Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection
Interventions: DRUG: AXA1125|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SUBA-Itraconazole Therapy for Coccidioidomycosis Refractory or Intolerant to Fluconazole
Status: WITHDRAWN
Conditions: Coccidioidomycosis|Valley Fever
Interventions: DRUG: SUBA-itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Magnesium to Prevent Postoperative Atrial Fibrillation Following Coronary Surgery (POMAF-CS)
Status: COMPLETED
Conditions: Atrial Fibrillation|Coronary Artery Disease|Surgery--Complications
Interventions: DRUG: Magnesium Sulfate|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Ticagrelor or Clopidogrel on Endothelial Function During Acute and Chronic Treatment
Status: COMPLETED
Conditions: Ischemia
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Monovalent and Bivalent Recombinant Protein Vaccines Against COVID-19 in Adults 18 Years of Age and Older
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent D614) (primary series)|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine (bivalent D614 + B.1.351) (primary series)|BIOLOGICAL: Placebo|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine (monovalent B.1.351) (booster dose) >= 4 months after last vaccination|BIOLOGICAL: SARS-CoV-2 adjuvanted recombinant protein vaccine(monovalent D614)(primary series)& SARS-CoV-2 adjuvanted recombinant protein vaccine(monovalent B.1.351)(booster dose)>=4 months after last vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons
Status: COMPLETED
Conditions: Acute and Long Term Effects of COVID-19 on Systemic Inflammation|Acute and Long Term Effects of COVID-19 on Lung Function|Acute and Long Term Effects of COVID-19 on Cardiac Function|Acute and Long Term Effects of COVID-19 on Kidney Function|Acute and Long Term Effects of COVID-19 on Brain Function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Acute Effect of and Energy Drink vs. Water Consumption on MAP, HR, and Energy Metabolism
Status: RECRUITING
Conditions: Cardiovascular Diseases|Hypertension|Diet
Interventions: DIETARY_SUPPLEMENT: Energy Drink|OTHER: Water Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION