pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Full Dose Heparin Vs. Prophylactic Or Intermediate Dose Heparin in High Risk COVID-19 Patients
Status: COMPLETED
Conditions: Sars-CoV2|COVID
Interventions: DRUG: Enoxaparin|DRUG: Prophylactic/Intermediate Dose Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir)
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: Shionogi Protease Inhibitor (S-217622)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for Advanced Hematologic Malignancies
Status: TERMINATED
Conditions: Preleukemia|Myeloproliferative Disorders|Lymphoma|Myeloma|Graft Versus Host Disease
Interventions: DRUG: Fludarabine|DRUG: Melphalan|DRUG: Campath
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Leber Hereditary Optic Neuropathy
Interventions: DRUG: rAAV2-ND4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AL-15469A for the Treatment of Bacterial Conjunctivitis
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: Moxifloxacin Alternative Formulation Ophthalmic Solution 0.5%|DRUG: Moxifloxacin hydrochloride ophthalmic solution 0.5% as base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ph I/II Study of Subcutaneously Administered Veltuzumab (hA20) in NHL and CLL
Status: COMPLETED
Conditions: NHL|Lymphoma, Non-Hodgkin|Lymphoma, B-Cell|Lymphoma, Follicular|Lymphoma, Intermediate-Grade|Lymphoma, Large-Cell|Lymphoma, Low-Grade|Lymphoma, Mixed-Cell|Lymphoma, Small-Cell|Leukemia, Lymphocytic, Chronic|Leukemia, B-Cell, Chronic|Leukemia, Prolymphocytic|Leukemia, Small Lymphocytic|Lymphoma, Small Lymphocytic|Lymphoma, Lymphoplasmacytoid, CLL|Lymphoplasmacytoid Lymphoma, CLL|CLL|SLL
Interventions: BIOLOGICAL: veltuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib and Panitumumab in Patients With Advanced or Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Microsatellite Stable Colorectal Carcinoma|Metastatic Microsatellite Stable Colorectal Carcinoma|Microsatellite Stable|RAS Wild Type|Stage IV Colorectal Cancer AJCC v8|MSI-H Colorectal Cancer
Interventions: DRUG: Niraparib|BIOLOGICAL: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dialysis-specific Therapeutic Diet on Biochemical Parameters in Dialysis Patients
Status: NOT_YET_RECRUITING
Conditions: End-Stage Kidney Disease
Interventions: OTHER: Dialysis-specific therapeutic diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Ranging Study Evaluating Efficacy and Safety of NI-03
Status: COMPLETED
Conditions: Chronic Pancreatitis
Interventions: DRUG: NI-03|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of Optical Diagnosis of Diminutive Colorectal Polyps: DISCARD3 Study (Incorporating AI-DETECT)
Status: COMPLETED
Conditions: Colonic Polyp
Interventions: DIAGNOSTIC_TEST: CAD polyp-detection system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy in Daily Use of a Novel Skin Care Product for the Treatment of Photoaged Skin
Status: UNKNOWN
Conditions: Photoaging
Interventions: OTHER: Topical anti-aging cosmetic cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α srRNA in Treating Advanced ICC Patients
Status: NOT_YET_RECRUITING
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: HNF4α srRNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Treatment as Prevention for HCV Among Persons Who Actively Inject Drugs
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: OTHER: modified directly observed therapy (mDOT)|OTHER: unobserved dosing|OTHER: Motivational Interviewing-based counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Romiplostim Plus Dexamethasone vs Dexamethasone in Patients With Newly Diagnosed Primary Immune Thrombocytopenia
Status: RECRUITING
Conditions: Primary Immune Thrombocytopenia
Interventions: DRUG: romiplostim plus dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Respiratory Effort in Preterm Infants
Status: COMPLETED
Conditions: Premature Birth
Interventions: PROCEDURE: High Flow Nasal Cannulae (HFNC)|PROCEDURE: Continuous Positive Airway Pressure (CPAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study)
Status: COMPLETED
Conditions: Neutropenia|Infection
Interventions: DRUG: Standard antimicrobial therapy|BIOLOGICAL: Granulocyte transfusions|DRUG: G-CSF/dexamethasone|DEVICE: Apheresis machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smart Removal for Congenital Diaphragmatic Hernia
Status: RECRUITING
Conditions: Congenital Diaphragmatic Hernia
Interventions: OTHER: Fetoscopic Endoluminal Tracheal Occlusion with the Smart-TO Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teduglutide for Enterocutaneous Fistula (ECF)
Status: COMPLETED
Conditions: Postoperative Fistula
Interventions: DRUG: Teduglutide|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Εffectiveness of Intrauterine Antibiotic Administration for Treatment of Chronic Endometritis
Status: RECRUITING
Conditions: Chronic Endometritis
Interventions: DRUG: Intrauterine infusion|DRUG: Oral administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Bioavailability of Dutasteride Novel Formulation Form to the Soft Gel Capsule Form in Healthy Male Subjects
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: dutasteride|DRUG: dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Prehabilitation and Early Mobilization for Patients Undergoing Pancreas Surgery.
Status: COMPLETED
Conditions: Pancreas Cancer
Interventions: OTHER: Prehabilitation|OTHER: Routine care|OTHER: Extra early mobilization|OTHER: Standard mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: One Talk at a Time: A Racial-ethnic Socialization Intervention for Diverse Families
Status: RECRUITING
Conditions: Depressive Symptoms|Anxiety Disorders and Symptoms|Behavioral Symptoms|Ethnic-Racial Socialization
Interventions: OTHER: One Talk at a Time: Race|OTHER: One Talk at a Time: General
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of Antioxidant (AT-001)for Reducing Brain Oxidative Stress
Status: COMPLETED
Conditions: Oxidative Stress
Interventions: DRUG: AT-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fuel Selection During Eccentric Cycling With Glucose Ingestion
Status: COMPLETED
Conditions: Exercise|Damage Muscle|Nutrition
Interventions: DIETARY_SUPPLEMENT: Solution ingestion|BEHAVIORAL: Constant load arm cranking|PROCEDURE: Expired gas sampling|PROCEDURE: Indirect respiratory calorimetry|PROCEDURE: Blood sampling|BEHAVIORAL: Measure of maximal voluntary contraction force production|DIAGNOSTIC_TEST: Measure of muscle electrical activity (EMG)|DIAGNOSTIC_TEST: Measure of central and cutaneous temperatures|DIAGNOSTIC_TEST: Measure of perceived exertion, pain perception and affective response|PROCEDURE: Measure of sweat and urine production
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sleep Disordered Breathing (SDB) Prevalence and Cardiovascular Outcomes of Myocardial Infarction (MI) Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myocardial Infarction|Sleep Apnea
Interventions: DIAGNOSTIC_TEST: Polygraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Bioequivalence Study of L04TD2 Compared to Administration of L04RD1 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: L04RD1|DRUG: L04TD2|DRUG: L04TD2|DRUG: L04RD1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacologic Treatment of Myocardial Ischemia Detected by Intracoronary ECG
Status: UNKNOWN
Conditions: Coronary Ischemia
Interventions: DRUG: Intracoronary bolus of adenosine (adenocor), Integrilin (eptifibatide) or nitroglyzerin (nitronal)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore
Status: COMPLETED
Conditions: Dengue Fever|Dengue Hemorrhagic Fever|Dengue Virus|Dengue Diseases
Interventions: BIOLOGICAL: CYD Dengue vaccine|BIOLOGICAL: NaCl + influenza virus or hepatitis A vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sorafenib Tosylate in Treating Patients With Locally Advanced, Metastatic, or Locally Recurrent Thyroid Cancer
Status: TERMINATED
Conditions: Anaplastic Thyroid Cancer|Insular Thyroid Cancer|Recurrent Thyroid Cancer|Stage III Follicular Thyroid Cancer|Stage III Papillary Thyroid Cancer|Stage IV Follicular Thyroid Cancer|Stage IV Papillary Thyroid Cancer
Interventions: DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|RADIATION: fludeoxyglucose F 18|PROCEDURE: positron emission tomography|PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
Status: RECRUITING
Conditions: Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Interventions: DRUG: Eplontersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric vs Jejunal Feeding in Diabetic Gastroparesis
Status: WITHDRAWN
Conditions: Diabetic Gastroparesis
Interventions: DIETARY_SUPPLEMENT: Jejunal Feed|DIETARY_SUPPLEMENT: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms
Status: RECRUITING
Conditions: Myeloproliferative Neoplasms
Interventions: DRUG: INCB160058
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proximal Humeral Comminuted Fractures in the Elderly - PERCELE Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Humeral Fracture
Interventions: PROCEDURE: locking plate, ORIF|PROCEDURE: Hemiarthroplasty|OTHER: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Overnight Pain Treatment Investigating Opioids vs. Nonopioids
Status: COMPLETED
Conditions: Abortion Second Trimester
Interventions: DRUG: Ibuprofen 600 mg|DRUG: OxyCODONE 5 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selective Inhibitor of Nuclear Export, Selinexor (KPT-330) in Combination With Paclitaxel and Carboplatin in Patients With Advanced Ovarian or Endometrial Cancers
Status: COMPLETED
Conditions: Ovarian Cancer|Endometrial Cancer
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-operative Management for Appendicitis in Children
Status: UNKNOWN
Conditions: Acute Focal Appendicitis|Appendicitis
Interventions: DRUG: Non-operative management group (NOM)|PROCEDURE: Appendectomy group (Operative management, OM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Individual Computer Aided Design/Manufactured (CAD/CAM) - Based Implants Consisting on Hydroxylapatite and Titanium to be Used in Cranioplasty
Status: TERMINATED
Conditions: Skull Defects|Cranioplasty
Interventions: DEVICE: Titanium implant (CranioConstruct™)|DEVICE: Hydroxylapatite (CustomBone)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Demonstrate the Efficacy and Safety of Adapalene/Benzoyl Peroxide Topical Gel in Subjects With Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene/Benzoyl Peroxide|DRUG: Adapalene|DRUG: Benzoyl Peroxide|DRUG: Topical Gel Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Life
Status: COMPLETED
Conditions: Chronic Liver Disease|Hepatic Encephalopathy
Interventions: DRUG: VSL#3|DRUG: Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Trastuzumab in Treating Patients With Stage II or Stage III Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|BIOLOGICAL: Trastuzumab|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Recombinant Von Willebrand Factor (rVWF) (TAK-577) in Children With Severe Von Willebrand Disease (vWD)
Status: NOT_YET_RECRUITING
Conditions: Von Willebrand Disease (VWD)
Interventions: BIOLOGICAL: Recombinant von Willebrand Factor (rVWF)|BIOLOGICAL: ADVATE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever
Status: COMPLETED
Conditions: Enteric Fever|Typhoid Fever
Interventions: DRUG: Ceftriaxone|DRUG: Gatifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lenvatinib, Pembrolizumab, and Fulvestrant in People With Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Lenvatinib|DRUG: Pembrolizuma|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Acupressure P6 Point, Dexamethasone and Ondansetron Versus Palonosetron Monotherapy for Preventing Postoperative Nausea and Vomiting in Laparoscopic Surgery
Status: COMPLETED
Conditions: Palonosetron
Interventions: OTHER: Acupressure wristband and Palanosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Effect of Lysozyme for Chronic Obstructive Pulmonary Disease and Asthma With Sputum Symptom
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Asthma
Interventions: DRUG: lysozyme 90 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: State-wide Health Approach to Increase Reach and Effectiveness: Study 1
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Shape Up Rhode Island + Online Resources|BEHAVIORAL: Shape Up Rhode Island + Online Weight Loss Program|BEHAVIORAL: Shape Up Rhode Island + Online Weight Loss Program + Group sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Steroids and Surfactant in Extremely Low Gestation Age Infants Dose Escalation Trial
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia (BPD)
Interventions: DRUG: Budesonide in Calfactant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of Fallot
Status: TERMINATED
Conditions: Tetralogy of Fallot
Interventions: DRUG: Dobutamin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Metformin Reduces Left Ventricular Mass in Patients With Ischemic Heart Disease
Status: COMPLETED
Conditions: Left Ventriclar Mass
Interventions: DRUG: Metformin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Anti-HER2 Bispecific Antibody ZW25 Activity in Combination With Chemotherapy With/Without Tislelizumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Gastric Cancer|Gastroesophageal Junction Cancer
Interventions: BIOLOGICAL: ZW25|DRUG: Docetaxel|BIOLOGICAL: Tislelizumab|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of Pedicle Screw Accuracy to Plan Using Medtronic Mazor Robotic System
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Deformity|Spinal Infection|Trauma|Neoplastic Processes|Degenerative Spinal Conditions
Interventions: DEVICE: Pedicle screw instrumentation using Mazor X robotic system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Dapivirine Vaginal Ring in Post-menopausal Women
Status: COMPLETED
Conditions: Human Immunodeficiency Virus
Interventions: DRUG: Dapivirine Vaginal Ring|DRUG: Placebo Vaginal Ring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Pupillary Distension Reflexes, as a Tool for the Monitoring of Analgesia for Patients in Intensive Care.
Status: COMPLETED
Conditions: Failure of Respiratory Function
Interventions: DEVICE: Measure the minimum intensity of a painful stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Shockwave Lithoplasty® Peripheral Lithoplasty System|DRUG: Medtronic IN.PACT (DCB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Aliskiren for Immunoglobulin A (IgA) Nephropathy
Status: COMPLETED
Conditions: IgA Nephropathy
Interventions: DRUG: Aliskiren|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intraocular Pressure Measured by a Novel Sensing Contact Lens Versus Tonometry
Status: NOT_YET_RECRUITING
Conditions: Glaucoma|Ocular Hypertension
Interventions: DEVICE: Goldfish (GF)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Aztreonam Aerosol to Treat Cystic Fibrosis Nasal Disease
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Oral Aztreonam|DRUG: Nasal Aztreonam|DRUG: Nasal Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Furmonertinib Combined With Radiotherapy for Non-small Cell Lung Cancer With Oligoprogression
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer|Oligoprogressive
Interventions: DRUG: Furmonertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph. II Temozolomide + O6-BG in Treatment of Pts w Temozolomide-Resistant Malignant Glioma
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Anaplastic Glioma
Interventions: DRUG: Temodar and O6-Benzylguanine (BG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT Face-to-face Group Voice Therapy vs Telepractice Group Voice Therapy for Muscle Tension Dysphonia
Status: RECRUITING
Conditions: Voice Disorders|Muscle Tension Dysphonia|Aphonia
Interventions: BEHAVIORAL: Telepractice group voice therapy|BEHAVIORAL: Face-to-face group voice therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effect of Transforaminal Injection of Magnesium Sulphate Versus Ozone Therapy on Oxidative Stress Biomarkers in Lumbar Disc Related Radicular Pain
Status: UNKNOWN
Conditions: Effect of Drug
Interventions: PROCEDURE: Transforaminal Epidural injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the TOMEY Specular Microscope EM-4000 and the Konan CellChek XL
Status: COMPLETED
Conditions: Corneal and Endothelial Cell Measurements
Interventions: DEVICE: Tomey EM-4000 Specular Microscope|DEVICE: Konan CellChek XL Specular Microscope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PBC Induced Fatigue Treated With Thiamine
Status: UNKNOWN
Conditions: Primary Biliary Cirrhosis
Interventions: DRUG: Thiamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of APG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDS
Status: RECRUITING
Conditions: AML|Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|CMML|Myelodysplastic Syndromes|High-risk Myelodysplastic Syndrome|MDS
Interventions: DRUG: APG-115|DRUG: 5-azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Provide Continued Access to Mitapivat for Participants Who Previously Completed an Agios-Sponsored Mitapivat Study
Status: ENROLLING_BY_INVITATION
Conditions: Pyruvate Kinase Deficiency|Anemia, Hemolytic
Interventions: DRUG: Mitapivat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robot-assisted Modified Kasai Portoenterostomy Versus Open Kasai Portoenterostomy for Biliary Atresia
Status: ACTIVE_NOT_RECRUITING
Conditions: Biliary Atresia|Kasai Operation|Robotic Surgery|Open Surgery
Interventions: PROCEDURE: robot-assisted modified Kasai portoenterostomy|PROCEDURE: traditional open Kasai portoenterostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Advanced Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer|Psychosocial Effects of Cancer and Its Treatment
Interventions: DRUG: cisplatin|DRUG: doxorubicin hydrochloride|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability of Sorafenib Tablet for Oral Suspension
Status: COMPLETED
Conditions: Biological Availability
Interventions: DRUG: Sorafenib (BAY43-9006) Film-coated tablet|DRUG: Sorafenib (BAY43-9006) Oral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Intranasal Oxytocin on Satiety Signaling in People With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ciclesonide Inhaled Once Daily Versus Other Corticosteroids Used for Treatment of Mild Asthma in Children (4 to 11 Years) (BY9010/CA-101)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Ciclesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Vaniprevir (MK-7009) and Hepatitis C Virus RNA Levels After Vaniprevir Treatment (MK-7009-029)
Status: TERMINATED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: Vaniprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Triamcinolone Acetonide to Reduce Pain After Scleral Buckle Surgery
Status: COMPLETED
Conditions: Retinal Detachment
Interventions: DRUG: Triamcinolone Acetonide 40mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Meal Tray as a Tool and Platform to Change Eating Habits Among Hospitalized Diabetic Patients - An Intervention Study
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Nutritional guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Standard-Dose Rituximab, Ifosfamide, Carboplatin and Etoposide
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|B-cell Lymphoma
Interventions: DRUG: Velcade (bortezomib), rituximab, ifosfamide, carboplatin, etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence
Status: RECRUITING
Conditions: Gastroesophageal Reflux Disease|GERD|Gastroesophageal Erosion|Erosive Esophagitis|Non-erosive Reflux Disease|Non-Erosive Gastro-Esophageal Reflux Disease
Interventions: BEHAVIORAL: diet adherence|BEHAVIORAL: No diet adherence|BEHAVIORAL: Change in physical activity|BEHAVIORAL: No change in physical activity|BEHAVIORAL: Use of antisecretory agents|BEHAVIORAL: No use of antisecretory agents
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pilot Study of Betaine + Combination Antiviral Therapy for Chronic Hepatitis C Genotype 1 Non-responder/Relapsers
Status: TERMINATED
Conditions: Chronic Hepatitis C|Genotype 1|Relapse
Interventions: DRUG: Betaine|DRUG: Peginterferon alpha 2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of High-flow Nasal Oxygen Flow Rate on Gas Exchange During Apnoea
Status: COMPLETED
Conditions: Apnea|Respiration; Arrest|Anesthesia
Interventions: PROCEDURE: Apnoeic oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Resectable Metastases of Osteosarcoma With Anti-angiogenics and CHemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteosarcoma|Pulmonary Metastases|Apatinib
Interventions: DRUG: Apatinib|DRUG: GD regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Electroacupuncture With Standard Therapy on Sperm Analysis and SOD Levels in Oligozoospermia.
Status: COMPLETED
Conditions: Oligozoospermia|Oligoasthenozoospermia|Oligoasthenoteratozoospermia
Interventions: OTHER: Electroacupuncture and Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neural Mechanisms of Mindfulness-based Cognitive Therapy (MBCT) for Posttraumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Post Traumatic Stress Disorder
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive Therapy|BEHAVIORAL: Muscle Relaxation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating E7389 in Patients With Hormone Refractory Prostate Cancer With Advanced and/or Metastatic Disease Stratified by Prior Chemotherapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: E7389
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dalotuzumab (MK-0646) in Combination With Cetuximab and Irinotecan in Metastatic Colorectal Cancer (MK-0646-004)
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: dalotuzumab|DRUG: irinotecan hydrochloride|BIOLOGICAL: cetuximab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Targeting CD19 and CD22 CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Acute B Lymphocytic Leukemia
Status: UNKNOWN
Conditions: Acute Lymphocytic Leukemia， B-Cell
Interventions: BIOLOGICAL: CD19-CD22 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Anlotinib Combined With Concurrent Chemoradiotherapy in Patients With Unresectable Stage III Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Anlotinib hydrochloride capsule Combined With Concurrent Chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile App Intervention for Sleep Problems and Alcohol Use Among Veterans
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder|Insomnia
Interventions: BEHAVIORAL: Enhanced Insomnia Coach|BEHAVIORAL: Sleep hygiene comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit
Status: RECRUITING
Conditions: Ventilator Associated Pneumonia
Interventions: DRUG: cotrimoxazole|DRUG: standard antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access Study of Gilteritinib (ASP2215) in Patients With FMS-like Tyrosine Kinase 3 (FLT3) Mutated Relapsed or Refractory Acute Myeloid Leukemia (AML) or FLT3-Mutated AML in Complete Remission (CR) With Minimal Residual Disease (MRD)
Status: APPROVED_FOR_MARKETING
Conditions: Acute Myeloid Leukemia (AML)|FMS-like Tyrosine Kinase-3 (FLT3) Mutations
Interventions: DRUG: gilteritinib
Study Type: EXPANDED_ACCESS
Clinical trial: Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma
Status: RECRUITING
Conditions: Hematoma, Subdural, Chronic
Interventions: DRUG: Tranexamic Acid 500Mg Tablet|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Week-long Psychological Treatment for PTSD With Ketamine
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess the Safety and Efficacy of CT0594CP Cells in Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia
Status: RECRUITING
Conditions: Relapsed and/or Refractory Multiple Myeloma|Plasma Cell Leukemia in Relapse
Interventions: OTHER: Biological
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FOCUS: A Phase I/II First in Human Study to Evaluate the Safety and Efficacy of GT005 Administered in Subjects With Dry AMD
Status: TERMINATED
Conditions: Dry Age-related Macular Degeneration|Macular Degeneration|Retinal Disease|Eye Diseases|Retinal Degeneration|Geographic Atrophy|Macular Atrophy
Interventions: BIOLOGICAL: GT005|BIOLOGICAL: GT005|BIOLOGICAL: GT005|BIOLOGICAL: GT005|DEVICE: GT005/ Device: Orbit™ Subretinal Delivery System|DEVICE: GT005/ Device: Orbit™ Subretinal Delivery System|DEVICE: GT005/ Device: Orbit™ Subretinal Delivery System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Via an Implantable Pump Compared With a Subcutaneous Port for Unresectable Liver Metastases in Patients With Resected Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Metastatic Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Pilot Study of the Efficacy and Safety of Q8003 in Patients Who Have Undergone Total Knee Arthroplasty or Total Hip Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Q8003 (morphine sulfate and oxycodone hydrochloride)|DRUG: Low dose Q8003 (morphine sulfate and oxycodone hydrochloride)|DRUG: Percocet (oxycodone and acetaminophen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study in Subjects With Seborrheic Dermatitis
Status: COMPLETED
Conditions: Seborrheic Dermatitis
Interventions: DRUG: Test Product 49778|DRUG: Test Product 10156|DRUG: Vehicle (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Core Stabilization Training in Juvenile Spondyloarthropathy
Status: RECRUITING
Conditions: Spondylarthritis|Spondylarthropathies|Juvenile Idiopathic Arthritis
Interventions: OTHER: core stabilization exercises|OTHER: daily physical activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Enhanced Safety Study of a Novel Coronavirus Messenger RNA (mRNA) Vaccine in Adults Aged 18 Years and Older.
Status: ENROLLING_BY_INVITATION
Conditions: Corona Virus Disease 2019(COVID-19)
Interventions: BIOLOGICAL: 0.3ml of mRNA vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Revision Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain|Knee Arthroplasty
Interventions: PROCEDURE: Adductor-Canal-Blockade with Ropivacaine|PROCEDURE: Adductor-Canal-blockade with saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Post-operative Pain After Direct Anterior Total Hip Arthroplasty
Status: TERMINATED
Conditions: Degenerative Joint Disease
Interventions: OTHER: L2 paravertebral block|OTHER: periarticular injection group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Family Intervention for Mental Illness and Substance Abuse
Status: COMPLETED
Conditions: Schizophrenia|Bipolar Disorder|Substance-related Disorders
Interventions: BEHAVIORAL: Family Intervention for Dual Diagnosis|BEHAVIORAL: Family psychoeducation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differential Gene Expression in Lung and Peripheral Blood After Inhaled Allergen Challenge
Status: TERMINATED
Conditions: Atopic Asthma|Healthy
Interventions: BIOLOGICAL: House Dust Mite|BIOLOGICAL: Diluent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trocar-site Infiltration Versus TAP-block
Status: UNKNOWN
Conditions: Laparoscopic Cholecystectomy
Interventions: PROCEDURE: Trocar-site infiltration|PROCEDURE: TAP block|PROCEDURE: Trocar site infiltration placebo|PROCEDURE: TAP block placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE-BC2)
Status: COMPLETED
Conditions: Malaria|Human Immunodeficiency Virus
Interventions: DRUG: Monthly dihydroartemisinin-piperaquine (DP) + daily trimethoprim/sulfamethoxazole (TS)|DRUG: Monthly placebo + daily trimethoprim/sulfamethoxazole (TS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PHOENIX DDR/Anti-PD-L1 Trial: A Pre-surgical Window of Opportunity and Post-surgical Adjuvant Biomarker Study of DNA Damage Response Inhibition and/or Anti-PD-L1 Immunotherapy in Patients With Neoadjuvant Chemotherapy Resistant Residual Triple Negative Breast Cancer
Status: RECRUITING
Conditions: Breast Neoplasm
Interventions: DRUG: AZD6738|DRUG: Olaparib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Integrated Solution for Sustainable Care for Multimorbid Elderly Patients With Dementia
Status: NOT_YET_RECRUITING
Conditions: Comorbidities and Coexisting Conditions|Alzheimer Disease|Dementia|Malnutrition|Frailty|Sarcopenia|Stroke|Asthma|Chronic Obstructive Pulmonary Disease|Chronic Kidney Diseases|Heart Failure|Diabetes|Coronary Artery Disease|Hypertension|Behavioral Symptoms
Interventions: OTHER: Intervention tested (CAREPATH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunct Immunotherapy With Immunoxel in Patients With TB and TB/HIV
Status: COMPLETED
Conditions: Tuberculosis|HIV
Interventions: DIETARY_SUPPLEMENT: Immunoxel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Three Warm-up Interventions at the Workplace Among Vineyard Workers - a Protocol Study
Status: COMPLETED
Conditions: Pain|Injuries
Interventions: OTHER: Hybrid Warm-up|OTHER: Dynamic Warm-up|OTHER: Stretching Warm-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Dry Needling and Manual Pressure Release for Managing Low Back Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Back Pain
Interventions: PROCEDURE: Manual pressure release|PROCEDURE: Dry needling|PROCEDURE: Heat therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise and Biofeedback on Symptoms of Incontinence in Women With Stress Urinary Incontinence
Status: TERMINATED
Conditions: Stress Urinary Incontinence
Interventions: OTHER: Pelvic floor exercises with biofeedback|OTHER: Pelvic floor muscle exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Phase II Trial of Doxil With or Without Dexamethasone for Metastatic Hormone Refractory Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: DRUG: dexamethasone|DRUG: doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapy
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: mixed salts amphetamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Intelligent Instrument for Improved Leg Length and Hip Offset Accuracy in Total Hip Arthroplasty
Status: UNKNOWN
Conditions: Hip Osteoarthritis|Leg Length Discrepancy|Dislocation
Interventions: DEVICE: Intellijoint HIP|DEVICE: Outrigger
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Visual Outcomes Following Bilateral Implantation of the Vivity Toric Intraocular Lens
Status: COMPLETED
Conditions: Cataract Senile|Intraocular Lens Complication
Interventions: DEVICE: AcrySof™ IQ Vivity™ Toric intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: COMBINATION_PRODUCT: E-cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I Study of the Safety, Pharmacokinetics, and Anti-Tumor Activity of CUDC-101 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: CUDC-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DK Score Coronary Scoring Balloon: a RCT Trial to Evaluate Acute Lumen Gain (SCORE CHINA)
Status: COMPLETED
Conditions: Coronary Stenosis
Interventions: DEVICE: DK ScoreTM Coronary Scoring Balloon|DEVICE: Non-Slip Element Coronary Dilatation Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Graft Patency in Beating Heart Vs. Conventional CABG Using Cardiac CT
Status: UNKNOWN
Conditions: Coronary Artery Disease Amenable to Bypass Graft Surgery
Interventions: PROCEDURE: Off-Pump Coronary Artery Bypass Graft Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT