pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: REVIVE: Replens Versus Intra-Vaginal Estrogen for the Treatment of Vaginal Dryness on Aromatase Inhibitor Therapy
Status: RECRUITING
Conditions: Estrogen Receptor Positive Breast Cancer|Breast Cancer
Interventions: DRUG: ESTRING|DRUG: Replens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery From Disability After Geriatric-home Rehabilitation Versus Standard of Care: Pilot Study
Status: NOT_YET_RECRUITING
Conditions: Disability Physical
Interventions: OTHER: The Geriatric Activation Program (GAPP) Home version|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Learn How Safe the Study Drug Intravitreal (Given by an Injection Into the Eye) Aflibercept is in Participants in India With Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAMELLIA: Anti-CD47 Antibody Therapy in Haematological Malignancies
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Hu5F9-G4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WOEST ( What is the Optimal antiplatElet & Anticoagulant Therapy in Patients With Oral Anticoagulation and Coronary StenTing)
Status: COMPLETED
Conditions: Anticoagulants|Platelet Aggregation Inhibitors|Stents|Atrial Fibrillation
Interventions: DEVICE: PCI (percutaneous coronary intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of a Putty as Gap Filler in Open-wedge Osteotomy
Status: RECRUITING
Conditions: Osteo Arthritis Knee
Interventions: PROCEDURE: Osteotomy with putty|PROCEDURE: Conventional osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesia in Major Gynecological Cancer Surgeries
Status: NOT_YET_RECRUITING
Conditions: Analgesia|Analgesia, Epidural|ERAS
Interventions: PROCEDURE: Patients who underwent epidural block|PROCEDURE: Patients who underwent erector spina plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: STeroids to REduce Systemic Inflammation After Infant Heart Surgery
Status: COMPLETED
Conditions: Congenital Heart Disease in Children|Inflammatory Response
Interventions: DRUG: Methylprednisolone|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of ETC-1002 in Subjects With Elevated Blood Cholesterol and Either Normal or Elevated Triglycerides
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: ETC-1002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness
Status: RECRUITING
Conditions: Opioid Use Disorder|Dual Diagnosis|Housing Problems|Mental Disorder in Adolescence|Risk Behavior|Homelessness
Interventions: BEHAVIORAL: Motivational Interviewing/Community Reinforcement Approach (MI/CRA)|BEHAVIORAL: Strengths-Based Outreach and Advocacy (SBOA )|BEHAVIORAL: Services as Usual (SAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation|Long-standing Persistent Atrial Fibrillation
Interventions: PROCEDURE: Pulmonary Vein Antrum Isolation|PROCEDURE: scar homogenization|PROCEDURE: Non-PV triggers ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paracetamol on Postoperative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Perfalgan|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Edge Computing Platform for Spine Health Risk Management Based on IoT Technology
Status: RECRUITING
Conditions: Cervical Disc Herniation|Cervical Spinal Stenosis|Ossification of Posterior Longitudinal Ligament|Neckbrace Device
Interventions: DEVICE: Wearable Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment Of Vascular Health After Niacin Therapy (AVANT)
Status: COMPLETED
Conditions: Coronary Artery Disease|Carotid Artery Disease|Peripheral Artery Disease
Interventions: DRUG: Niacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy
Status: RECRUITING
Conditions: Neuropathy, Diabetic|Small Nerve Fiber Neuropathy|Type 1 Diabetes
Interventions: DIAGNOSTIC_TEST: Skin biopsies with quantification of intra-epidermal nerve fibre density|DIAGNOSTIC_TEST: Perception Threshold Tracking|DIAGNOSTIC_TEST: Thermal perception thresholds|DIAGNOSTIC_TEST: Corneal confocal Microscopy|DIAGNOSTIC_TEST: MRI|DIAGNOSTIC_TEST: Nerve conduction studies|OTHER: Composite scores and questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Assessment of the Safety of a Combination of Curcumin, Omega-3, and Vitamin D Supplements
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DIETARY_SUPPLEMENT: Curcumin, Omega-3 and Vitamin-D (COD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiologic Effects of Noninvasive Neurally Adjusted Ventilatory Assist (NAVA) Versus Noninvasive Pressure Support Ventilation in Patients at Risk for Respiratory Distress Needed Preventive Used of Noninvasive Ventilation After Extubation.
Status: COMPLETED
Conditions: Acute Respiratory Distress
Interventions: DEVICE: Noninvasive neurally adjusted ventilatory assist (NIV-NAVA).|DEVICE: Noninvasive pressure support ventilation (NPSV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preemptive Analgesic Efficacy of Parecoxib for Reducing Postoperative Pain in Gynecological Surgery
Status: RECRUITING
Conditions: Preemptive Analgesia|Gynecological Surgery|Postoperative Pain|Parecoxib
Interventions: DRUG: Parecoxib|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paroxysmal Positional Vertigo & Repositioning Maneuvers
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: OTHER: Modified eply & Semont maneuver|OTHER: betahistine & Modified eply & Semont maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Human Rhinovirus Type 16 (HRV-16) Following Administration in the Nose of Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: HRV-16 (100 TCID50)|BIOLOGICAL: HRV-16 (1000 TCID50)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Chemoradiotherapy for Patients With Oligometastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colorectal Cancer|Metastases
Interventions: DRUG: Capecitabine|DRUG: Bevacizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Rate of Successful Intubation and the Required Time for Intubation, Using Vie Scope and Macintosh Laryngoscope Will be Compared, in Order to Evaluate the Efficacy of Vie Scope in Comparison With Macintosh in Expected Easy Airways.
Status: RECRUITING
Conditions: Laryngoscopy
Interventions: DEVICE: Macintosh laryngoscope|DEVICE: Vie Scope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Enzalutamide vs. Abiraterone in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC)
Status: COMPLETED
Conditions: Prostatic Neoplasms, Castration-Resistant
Interventions: DRUG: Enzalutamide|DRUG: Abiraterone acetate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 2 Study to Evaluate the Preliminary Performance of the C13-URA Breath Test Kit in Dyspeptic Subjects
Status: COMPLETED
Conditions: Dyspeptic Subjects
Interventions: DRUG: 13C-uracil|DRUG: 99mTc sulfur colloid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of the Incoportation of Copper and Zinc Nanoparticles Into Dental Adhesives
Status: UNKNOWN
Conditions: Caries, Dental
Interventions: OTHER: Metal nanoparticles ( O Zn and Cu)|OTHER: Dental Adhesive pure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling
Status: RECRUITING
Conditions: Mitochondrial Diseases|Bone Remodeling Disorder
Interventions: DIAGNOSTIC_TEST: Clinical assessment, blood samples, bone marrow and bone biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Drusen Morphology Changes in Nonexudative Age-related Degeneration After Oral Antioxidants Supplementation
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DIETARY_SUPPLEMENT: Antioxidant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: OASIS: Osteoarthritis Sensitivity Integration Study
Status: WITHDRAWN
Conditions: Osteoarthritis|Chronic Pain
Interventions: OTHER: Phenotype assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery
Status: NOT_YET_RECRUITING
Conditions: Delirium, Postoperative
Interventions: DRUG: Liraglutide injection|DRUG: Placebo injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Intravenous Omega 3 Fatty Acids Administration in Valvular Surgery Patients
Status: COMPLETED
Conditions: Valvular Surgery|Inflammation
Interventions: DIETARY_SUPPLEMENT: Omegaven-IV FO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Concurrent Induction Chemoimmunotherapy With Epirubicine, Oxaliplatin, Capecitabine and Panitumumab in KRAs Wild-type, Resectable Type II Gastric Adenocarcinoma
Status: TERMINATED
Conditions: KRAS Wild Type|Resectable Type II Gastric Adenocarcinoma
Interventions: DRUG: Epirubicine, Oxaliplatin, Capecitabine, Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus
Status: UNKNOWN
Conditions: Normal Pressure Hydrocephalus
Interventions: PROCEDURE: Endoscopic Third Ventriculostomy|PROCEDURE: Ventriculo-Peritoneal Shunting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction Effects of Vitamin D Supplementation and Aerobic Exercises on Balance and Physical Performance in Children With Down Syndrome
Status: COMPLETED
Conditions: Children With Down Syndrome
Interventions: COMBINATION_PRODUCT: Aerobic exercises and Vitamin D supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Volar Locking Plate Versus External Fixation for Distal Radius Fracture - a Longterm Follow up
Status: UNKNOWN
Conditions: Radius Fracture Distal|Surgery|Surgery--Complications|Treatment Complication|Tendon Injuries|Tendon Rupture|Surgical Site Infection|CRPS Type I|CRPS Type II|Dislocation|Osteoarthritis
Interventions: PROCEDURE: Volar locking plate|PROCEDURE: external fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Basal Insulin Analog and Insulin Analog Mid Mixture in Chinese Participants With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Insulin Analog Mid Mixture|DRUG: Basal Insulin Analog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: Epigallocatechin gallate (EGCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Zimberelimab Combined With Albumin-bound Paclitaxel and Cisplatin in Neoadjuvant Treatment of LACC
Status: RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: DRUG: Zimberelimab|DRUG: Albumin-bound Paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of the Safety and Effectiveness of CHR-2797 With Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: CHR-2797 (tosedostat)|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Postoperative Pain After Pericapsular Nerve Block and Fascia Iliaca Block in Total Hip Arthroplasty
Status: RECRUITING
Conditions: Anesthesia
Interventions: PROCEDURE: fascia iliaca compartment block|PROCEDURE: pericapsular nerve block|PROCEDURE: palcebo fascia iliaca compartment block|PROCEDURE: palcebo pericapsular nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Oocyte Activation: Revised or Initial AGT Technique, Which is Better?! A Sibling-oocytes-split Design
Status: COMPLETED
Conditions: Assisted Reproductive Technology
Interventions: PROCEDURE: Assisted gamete activation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Salsalate, Venetoclax, and Decitabine or Azacitidine for the Treatment of Acute Myeloid Leukemia or Advanced Myelodysplasia/Myeloproliferative Disease
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia|Myeloblasts 10 Percent or More of Bone Marrow Nucleated Cells|Myelodysplastic Syndrome|Myeloproliferative Neoplasm|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: Decitabine|DRUG: Salsalate|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potato Research for Enhancing Metabolic Outcomes
Status: COMPLETED
Conditions: Insulin Resistance|Obesity
Interventions: OTHER: Reduced Meat High Potato Diet|OTHER: Reduced Meat High Pulses Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery
Status: COMPLETED
Conditions: Myocardial Injury
Interventions: BEHAVIORAL: Exercise training|PROCEDURE: remote ischemic preconditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: AZISAST Study: AZIthromycin in Severe ASThma Study
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Azithromycin 250 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)
Status: COMPLETED
Conditions: Spasticity|Multiple Sclerosis
Interventions: DRUG: Sativex®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis
Status: COMPLETED
Conditions: Pleural Effusion|Exudative Pleuritis
Interventions: PROCEDURE: Therapeutic thoracentesis|DEVICE: Pleural catheter|DEVICE: Pleural manometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety of INT2104 in Participants Aged 18 Years and Older Who Have B-cell Cancer That Came Back After Prior Treatment
Status: RECRUITING
Conditions: Lymphomas Non-Hodgkin's B-Cell|Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions: GENETIC: INT2104
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Brentan (miconazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Subtalar, Double, or Triple Arthrodesis Study With CCS Screws
Status: COMPLETED
Conditions: Post-traumatic Osteoarthritis, Unspecified Ankle and Foot|Localized, Primary Osteoarthritis of the Ankle and/or Foot
Interventions: DEVICE: Aptus CCS 5.0 or/and 7.0 screws
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Video Information Provider for HIV-Associated Non-AIDS (VIP-HANA) Symptoms
Status: COMPLETED
Conditions: HIV (Human Immunodeficiency Virus)|AIDS (Acquired Immunodeficiency Syndrome)
Interventions: BEHAVIORAL: VIP app without HIV-related symptom strategies.|BEHAVIORAL: VIP app that delivers HIV-related symptom strategies.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI
Status: COMPLETED
Conditions: ST Segment Elevation Myocardial Infarction|Percutaneous Coronary Intervention
Interventions: DRUG: Cangrelor|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Hip and Core Muscle Strengthening for Patellofemoral Osteoarthritis: A Feasibility Study
Status: COMPLETED
Conditions: Patellofemoral Osteoarthritis
Interventions: OTHER: Supervised exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Choice Architecture and Colorectal Cancer Screening Outreach
Status: COMPLETED
Conditions: Cancer of Colon
Interventions: BEHAVIORAL: Colonoscopy only|BEHAVIORAL: Colonoscopy outreach + mailed FIT follow-up|BEHAVIORAL: Colonoscopy + Mailed FIT outreach and follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Sinus Lift With Newly Forming Bone and Inorganic Bovine Bone
Status: COMPLETED
Conditions: Maxillary Sinus
Interventions: PROCEDURE: Sinus lift|PROCEDURE: Surgical alveolus|PROCEDURE: Inorganic bovine bone + newly forming bone|PROCEDURE: Inorganic bovine bone|DEVICE: Collagen membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: carboplatin|DRUG: tamoxifen citrate|DRUG: topotecan hydrochloride|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving HbA1c Levels by Methylcobalamin Vitamin in Diabetic Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Vitamin B12 0.5 MG/ACTUAT|DRUG: Dapagliflozin 10mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Visual Outcomes and the Predictive Factors in Chinese Patients With Diabetic Macular Edema Treated With Ranibizumab
Status: UNKNOWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of IgG4-Related Disease With Revlimid and Rituximab
Status: COMPLETED
Conditions: Immunoglobulin G Subclass 4 Related Disease|IgG4-related Disease|Autoimmune Pancreatitis|IgG4-related Sclerosing Cholangitis|Retroperitoneal Fibrosis
Interventions: DRUG: Rituximab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Pharmacokinetics of Inhaled Ciprofloxacin in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Ciprofloxacin (PulmoSphere, BAYQ3939)|DRUG: Ciprofloxacin (PulmoSphere, BAYQ3939)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Patient in Laparoscopic Colon Surgery:Impact of Comorbidities,Frailty,Malnutrition and Sarcopenia on Short-term Mortality
Status: COMPLETED
Conditions: Colon Cancer|Malnutrition|Sarcopenia|Comorbidities and Coexisting Conditions
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Minimum Effective Dose of 0.5% Bupivacaine for Ultrasound-guided Spinal Anesthesia Using Taylor's Approach
Status: COMPLETED
Conditions: Lower Limb Surgery
Interventions: PROCEDURE: spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observation Study With Implantable Medication Pump for Intravenous Treprostinil Therapy in Patients With Pulmonary Arterial Hypertension
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension|PAH
Interventions: COMBINATION_PRODUCT: Treprostinil via implanted pump
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effects of HMB, ATP, and HMB Plus ATP on Muscle Mass, Strength, and Power in Resistance Trained Athletes
Status: COMPLETED
Conditions: Healthy Experienced Weight Training Males
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: HMB|DIETARY_SUPPLEMENT: Peak ATP and HMB|DIETARY_SUPPLEMENT: ATP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antibiotic Prophylaxis for Clean Intermittent Catheterisation
Status: COMPLETED
Conditions: Urinary Tract Infections, Recurrent
Interventions: DRUG: Nitrofurantoin or Trimethoprim or Cefalexin|OTHER: No prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Aerobic and Resisted Exercise on Lipid Profile and Quality of Life in Overweight Breastfeeding Women
Status: COMPLETED
Conditions: Postpartum Weight Retention
Interventions: OTHER: Nutritional recommendation and Faradic stimulation program|OTHER: aerobic and resisted exercise for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Ketamine group|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Disinfecting Solutions and Protein Remover With a Silicone Hydrogel Lens
Status: COMPLETED
Conditions: Ametropia
Interventions: DRUG: Alcon Opti-Free® RepleniSH® with Supraclens®|DRUG: Alcon Opti-Free® RepleniSH®|DRUG: B&L ReNu MultiPlus™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Pre Surgery Dog Visits on Post Surgery Consumption of Pain Medication
Status: WITHDRAWN
Conditions: Post Tonsillectomy Pain
Interventions: BEHAVIORAL: Therapy dog|BEHAVIORAL: Costumed character|BEHAVIORAL: Parents-only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Treatment of COVID-19 Patients With Anti-interleukin Drugs
Status: COMPLETED
Conditions: COVID-19
Interventions: OTHER: Usual Care|DRUG: Anakinra|DRUG: Siltuximab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dorsomedial rTMS For Depression In Borderline Personality Disorder
Status: UNKNOWN
Conditions: Borderline Personality Disorder|Major Depression
Interventions: DEVICE: Dorsomedial prefrontal rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Epiduo gel|DRUG: BPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of RD01 (Pegerythropoietin) in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: RD01|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Bioavailability of SHR0302 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: SHR0302|DRUG: SHR0302|DRUG: SHR0302|DRUG: SHR0302|DRUG: SHR0302|DRUG: SHR0302
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of the Safety and Tolerability of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosis
Status: COMPLETED
Conditions: Parkinson's Disease Psychosis
Interventions: DRUG: Pimavanserin tartrate (ACP-103)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Acupuncture for Complications in Critically Ill Patients
Status: UNKNOWN
Conditions: Delirium|Agitation|Arrhythmia|Feeding Intolerance|Pain, Acute
Interventions: OTHER: pess tack acupuncture|OTHER: pess tack placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Correlation of Audiovisual Features With Clinical Variables and Neurocognitive Functions in Bipolar Disorder, Mania
Status: COMPLETED
Conditions: Bipolar Disorder, Manic|Artificial Intelligence|Neurocognition|Treatment Resistant Disorders|Affective Computing|Multi- Modal Analysis
Interventions: DRUG: Ongoing treatment for bipolar mania|DIAGNOSTIC_TEST: Audiovisual recording during guided presentation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of CellCept (Mycophenolate Mofetil) in Patients With Lupus Nephritis.
Status: TERMINATED
Conditions: Lupus Nephritis
Interventions: DRUG: Mycophenolate Mofetil|DRUG: Corticosteroids|DRUG: Azathioprine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of REX-001 to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM
Status: TERMINATED
Conditions: Peripheral Arterial Disease (PAD)|Diabetes Mellitus (DM)|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2|Cardiovascular Disease|Critical Limb Ischemia (CLI)
Interventions: DRUG: REX-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Theta Phase-specific TMS to Modulate Prefrontal Activity
Status: RECRUITING
Conditions: Approach/Avoidance Behavior
Interventions: DEVICE: Transcranial magnetic stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Prove the Non-inferiority of DLMR01 by Evaluating the Injecting Efficacy and Safety DLMR01 and Control for Patients in Crow's Feet
Status: COMPLETED
Conditions: Crow's Feet Lines
Interventions: DEVICE: DLMR01|DEVICE: Rejuran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of an Amoxicillin-Clavulanic
Status: COMPLETED
Conditions: Infections, Respiratory Tract
Interventions: DRUG: 400 mg Amoxicillin + 57 mg Clavulanic Acid/ 5 ml|DRUG: 400 mg Amoxicillin + 57 mg Clavulanic Acid/ 5 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets Versus Venlafaxine Hydrochloride Sustained-release Tablets in Patients With Major Depression Disorder
Status: RECRUITING
Conditions: Major Depression Disorder
Interventions: DRUG: Toludesvenlafaxine hydrochloride sustained-release tablets|DRUG: Venlafaxine hydrochloride sustained-release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Oil Pulling
Status: COMPLETED
Conditions: Oral Hygiene|Dental Plaque
Interventions: DRUG: Chlorhexidine|OTHER: Oil Pulling|OTHER: Distilled Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ICP-248 in Combination With Orelabrutinib in Treatment-naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: RECRUITING
Conditions: Hematologic Malignancies
Interventions: DRUG: ICP-248|DRUG: Orelabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy .
Status: UNKNOWN
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: One-layer Duct-to-mucosa Pancreaticojejunostomy|PROCEDURE: Two-layer Duct-to-mucosa Pancreaticojejunostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mindfullnes-Based Cognitive Therapy Effect
Status: COMPLETED
Conditions: Mindfullnes-Based Cognitive Therapy and Adherence to Immunosuppressive Therapy
Interventions: BEHAVIORAL: Mindfullnes-Based Cognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Intraoperative Hypotension on Postoperative Cognitive Functions in Cesarean Section Operations
Status: RECRUITING
Conditions: Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: Hypotension during spinal anesthesia for cesarean section|DIAGNOSTIC_TEST: Mini-mental test|PROCEDURE: Spinal anesthesia|DIAGNOSTIC_TEST: The Bromage scale|DRUG: Heavy Bupivacaine for spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Pediatric Chronic Headache Trial
Status: UNKNOWN
Conditions: Headache
Interventions: BEHAVIORAL: Coping Skills Training|BEHAVIORAL: Headache Education|DRUG: Amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 0.018 or 0.022 Bracket Slot System More Effective in Orthodontic Treatment?
Status: COMPLETED
Conditions: Malocclusion
Interventions: DEVICE: Orthodontic bracket slot system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth Powerful Tools for Caregivers Effectiveness Study
Status: COMPLETED
Conditions: Caregivers
Interventions: BEHAVIORAL: Telehealth Delivery Format|BEHAVIORAL: Standard Delivery Format
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cadonilimab + FOLFOX Versus FOLFOX in the Neoadjuvant Treatment of pMMR/MSS Locally Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Locally Advanced Colorectal Carcinoma
Interventions: DRUG: Cadonilimab|DRUG: FOLFOX regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Contrast Perfusion Using Arterial Spin Labeled MR Imaging for Assessment of Therapy Response in Metastatic Renal Cell Carcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: MRI with ASL
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Plastic Covering Method for Self-gripping Mesh Placement in Laparoscopic Inguinal Hernia Repair
Status: UNKNOWN
Conditions: Laparoscopic Inguinal Hernia Repair
Interventions: OTHER: self-gripping mesh placement with plastic sheath in laparoscopic inguinal hernia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exploration of the Value of PSMA PET/CT in Dynamic Monitoring of the Efficacy of Novel Endocrine Therapy in Patients With Metastatic Hormone Sensitive Prostate Cancer
Status: NOT_YET_RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: DIAGNOSTIC_TEST: PSMA PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Pharmacokinetics of Ketoconazole|Healthy Adult Volunteers
Interventions: DRUG: Isavuconazole|DRUG: Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety of Jianpi Qinghua Granules in Patients With Nonerosive Reflux Disease
Status: UNKNOWN
Conditions: Nonerosive Reflux Disease
Interventions: DRUG: Jianpi Qinghua granules|DRUG: Jianpi Qinghua placebo granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Gastric Mucosal Ablation as a Primary Obesity Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Adiposity
Interventions: DEVICE: Hybrid Argon Plasma Coagulation (HAPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Powdered Tart Cherries on Recovery From Repeated Sprints
Status: COMPLETED
Conditions: Inflammation|Oxidative Stress|Soreness, Muscle|Muscle Damage
Interventions: DIETARY_SUPPLEMENT: Tart Cherry Extract Powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Acupressure for Fatigue in Ovarian Cancer Survivors
Status: COMPLETED
Conditions: Fatigue|Ovarian Cancer
Interventions: OTHER: Acupressure|OTHER: Sham acupressure|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Coffee Consumption, the Gut Microbiome, and the Microbiota-Gut-Brain Axis
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Caffeinated coffee|OTHER: Decaffeinated coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interferon Alpha 2b Plus Ribavirin for Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: interferon alpha 2b plus ribavirin|DRUG: interferon alpha 2b plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Impact of Adapted Physical Activity on Patient's Recovery Following Allogeneic Stem Cell Transplantation for Hematological Malignancy
Status: RECRUITING
Conditions: Haematological Malignancy
Interventions: OTHER: 6 sessions of adapted physical activity after stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin D, Omega-3, and Combination Vitamins B, C and Zinc Supplementation for the Treatment and Prevention of COVID-19
Status: WITHDRAWN
Conditions: Covid19
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Omega DHA / EPA|DIETARY_SUPPLEMENT: Vitamin C, Vitamin B complex and Zinc Acetate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of YH14617 in Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: YH14617|DRUG: YH14617|DRUG: YH14617|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Dasatinib, or Nilotinib
Status: COMPLETED
Conditions: Adult Acute Lymphoblastic Leukemia in Remission|Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Blastic Phase|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase of Disease|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Disease
Interventions: DRUG: Cyclosporine|DRUG: Dasatinib|DRUG: Fludarabine Phosphate|DRUG: Imatinib Mesylate|DRUG: Mycophenolate Mofetil|DRUG: Nilotinib|PROCEDURE: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|PROCEDURE: Peripheral Blood Stem Cell Transplantation|BIOLOGICAL: Therapeutic Allogeneic Lymphocytes|RADIATION: Total-Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Cancer-associated Fibroblast, MDSCs and Immune Cell Interplays in the Resistance of Non-small Cell Lung Cancer to Anti-PD1/PD-L1 Therapies
Status: NOT_YET_RECRUITING
Conditions: Lung Neoplasm|Cancer Associated Fibroblast|Myeloid-Derived Suppressive Cells Immunosuppression
Interventions: PROCEDURE: Tumor samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Regorafenib in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Adenoid Cystic Carcinoma
Interventions: DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologuos Lymphoid Effector Cells Specific Against Tumour (ALECSAT) as Add on to Standard of Care in Patients With Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: BIOLOGICAL: ALECSAT|RADIATION: Radiotherapy|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess Effects Of PF-04958242 On Bold Functional Magnetic Resonance Imaging During Working Memory Activation And Arterial Spin Labeling At Rest In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Placebo|DRUG: PF-04958242
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Transcutaneous Electrical Nerve Stimulation During Delivery
Status: UNKNOWN
Conditions: Anxiety, Hormone, Labour, Pain, Midwife, Pregnant, Transcutaneous Electrical Nerve Stimulation
Interventions: DEVICE: transcutaneous electrical nerve stimulation device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 2, Multicentre, Randomized, Double-blind, Placebo-controlled Study in Patients With New-onset Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Insulin-Dependent
Interventions: DRUG: Ladarixin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics as Adjunct to Non Surgical Periodontal Therapy for Pregnant Women Oral Health
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: OTHER: Biorepair Toothpaste + Mousse|OTHER: Biorepair Toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Choice Sets for Advance Directives
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: BEHAVIORAL: Expanded AD Choice|BEHAVIORAL: Expanded Life-sustaining Therapy Choice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection
Status: COMPLETED
Conditions: HIV Infections|Tuberculosis
Interventions: DRUG: Isoniazid|DRUG: Pyrazinamide|DRUG: Pyridoxine hydrochloride|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION