pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety Tolerability & Pharmacokinetics of Co-administered Single Doses of OZ439 & Piperaquine to Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 100mg OZ439 single oral dose|DRUG: Placebo|DRUG: 300 mg OZ439 single oral dose|DRUG: 160mg Piperaquine single oral dose|DRUG: 480mg Piperaquine single oral dose|DRUG: 1440mg Piperaquine single oral dose|DRUG: 800 mg OZ439 single oral dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Efficacy and Safety of Pexidartinib in Adult Subjects With TGCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Tenosynovial Giant Cell Tumor
Interventions: DRUG: Pexidartinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test Whether Study Drug BAY1128688 Brings Pain Relief to Women With Endometriosis and if so to Get a First Idea Which Dose(s) Work Best
Status: TERMINATED
Conditions: Endometriosis
Interventions: DRUG: BAY1128688|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XELOX Plus Cetuximab as First-Line Therapy in Patients With Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Carcinoma
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumor
Interventions: DRUG: belinostat|DRUG: 5-Fluorouracil (5-FU)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Dextrose Gel for Newborns at High-risk for Hypoglycemia
Status: COMPLETED
Conditions: Hypoglycemia|Infant, Small for Gestational Age|Premature Birth of Newborn|Fetal Macrosomia|Intrauterine Growth Restriction|Complication of Prematurity|Neonatal Hypoglycemia
Interventions: DIETARY_SUPPLEMENT: 40% Dextrose gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Everolimus (RAD001) in Elderly Patients With Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: RAD001(Everolimus)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Treatment, Drug Treatment, and Combined Treatment for Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: Methylphenidate 0.15 mg/kg|BEHAVIORAL: Low-Intensity BMOD|DRUG: Methylphenidate 0.3 mg/kg|DRUG: Placebo|DRUG: Methylphenidate 0.6 mg/kg|BEHAVIORAL: High Intensity BMOD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
Status: UNKNOWN
Conditions: Disorder|Heart|Postoperative|Cardiac Surgery
Interventions: OTHER: Restrictive Transfusion Strategy|OTHER: Liberal transfusion strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HQP1351 in Patients With GIST or Other Solid Tumors
Status: RECRUITING
Conditions: Gastrointestinal Stromal Tumor (GIST)|Solid Tumor, Adult
Interventions: DRUG: HQP1351
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery
Status: RECRUITING
Conditions: Arthritis Knee|Spine Fusion|Prostate Cancer|Arthritis of Hip|Hepatic Cancer
Interventions: DRUG: TXA|DIAGNOSTIC_TEST: TEG6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Propofol as ICU Sedation
Status: COMPLETED
Conditions: Ketamine|Propofol|Sedation|Mechanical Ventilation
Interventions: DRUG: Ketamine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: To Demonstrate the Non-inferiority of Eyestil Protection® Compared to Vismed® in Terms of Clinical Performance
Status: TERMINATED
Conditions: Dry Eye Syndrome
Interventions: DEVICE: Eyestil Protection® unidose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparative Effects of Aspirin and NHP-544C
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Bradykinin|DRUG: Aspirin 81 mg|DRUG: Aspirin 162 mg|DRUG: NHP544-C 81 mg|DRUG: NHP544C 162 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Docetaxel in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: VEGFR/PDGFR dual kinase inhibitor X-82|DRUG: docetaxel|OTHER: fluorine F 18 fluorothymidine|PROCEDURE: positron emission tomography/computed tomography|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers
Status: COMPLETED
Conditions: Contact Lens Discomfort|Dry Eye Disease|Meibomian Gland Dysfunction
Interventions: DEVICE: Bruder Moist Heat Compress|OTHER: Washcloth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Azacitidine|DRUG: Valproic Acid|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Implant Provision by Community Health Extension Workers With Nurses and Midwives in Nigeria
Status: COMPLETED
Conditions: Contraception
Interventions: OTHER: Training CHEWs to provide contraceptive implants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine (CAIV-T) in Healthy Children
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: CAIV-T 10^7|BIOLOGICAL: CAIVT 10^5|BIOLOGICAL: Placebo|BIOLOGICAL: TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise in Patients With a Total Coronary Occlusion
Status: TERMINATED
Conditions: Coronary Occlusion
Interventions: OTHER: Symptom limited cardiopulmonary exercise test & Sub-maximal cardiopulmonary exercise test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy
Status: COMPLETED
Conditions: High Risk Pregnant Women|Placental Insufficiency|Preeclampsia
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: To Evaluate Efficacy and Safety of Parsaclisib Plus Either Rituximab or Obinutuzumab in R/R Follicular Lymphoma (FL) and Marginal Zone Lymphoma (MZL) (CITADEL-302)
Status: WITHDRAWN
Conditions: Follicular Lymphoma ( FL)|Marginal Zone Lymphoma (MZL)
Interventions: DRUG: parsaclisib|DRUG: rituximab|DRUG: obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Daily CF101 Administered Orally in Subjects With Elevated Intraocular Pressure
Status: COMPLETED
Conditions: Ocular Hypertension|Glaucoma
Interventions: DRUG: CF101|DRUG: Placebo for
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MANual vs. automatIC Local Activation Time Annotation for Guiding Premature Ventricular Complex Ablation
Status: COMPLETED
Conditions: Ventricular Premature Complexes|Catheter Ablation
Interventions: DEVICE: Automatic annotation of LAT (WF-method)|DEVICE: Manual annotation of LAT (M-method)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CIPRO XR Versus CIPRO IR in Patients With Complicated Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: Cipro XR (Ciprofloxacin, BAYQ3939)|DRUG: Cipro IR (Ciprofloxacin, BAYQ3939)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Antiviral Effect of ABT-450/Ritonavir and ABT-530 Coadministered With and Without Ribavirin in Adults With Genotype 3 Hepatitis C (HCV) Infection
Status: COMPLETED
Conditions: Chronic Hepatitis C|Hepatitis C Virus
Interventions: DRUG: ABT-450/ritonavir (r)|DRUG: ABT-530|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Music in Reducing Anxiety and Pain in Adult Patients Undergoing Bone Marrow Biopsy for Hematologic Cancers or Other Diseases
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Pain|Precancerous Condition|Psychosocial Effects of Cancer and Its Treatment
Interventions: PROCEDURE: music therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaccine Therapy With or Without Fludarabine in Treating Patients With Stage IV Kidney Cancer
Status: UNKNOWN
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: autologous tumor cell vaccine|BIOLOGICAL: keyhole limpet hemocyanin|BIOLOGICAL: therapeutic autologous dendritic cells|DRUG: fludarabine phosphate|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy of Tai Chi Versus CBT-I in Treating Chronic Insomnia in Older Adults
Status: COMPLETED
Conditions: Chronic Insomnia
Interventions: BEHAVIORAL: Tai Chi Group|BEHAVIORAL: CBT-I Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
Status: COMPLETED
Conditions: FTLD|Progressive Supranuclear Palsy (PSP)|Frontotemporal Dementia (FTD)|Corticobasal Degeneration (CBD)|PPA Syndrome|Behavioral Variant Frontotemporal Dementia (bvFTD)|Semantic Variant Primary Progressive Aphasia (svPPA)|Nonfluent Variant Primary Progressive Aphasia (nfvPPA)|FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)|Amyotrophic Lateral Sclerosis (ALS)|Oligosymptomatic PSP (oPSP)|Corticobasal Syndrome (CBS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Real-world Study of Efficacy and Safety of ICIs and TKIs Therapy for HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Programmed Cell Death 1|Effects of Immunotherapy
Interventions: DRUG: Lenvatinib Oral Product|DRUG: PD-1 inhibitor|PROCEDURE: Local treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Different Feeding in Traumatic Brain Injury Patients
Status: RECRUITING
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Rehabilitation therapy|DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric tube feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Eltrombopag Treatment of Thrombocytopenia in Subjects With Advanced Myelodysplastic Syndrome (MDS) or Secondary Acute Myeloid Leukemia After MDS (sAML/MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: eltrombopag olamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Strawberries in a Cholesterol-Lowering Dietary Portfolio
Status: COMPLETED
Conditions: Hyperlipidemia|Cardiovascular Diseases|Hypercholesterolemia
Interventions: PROCEDURE: strawberry dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nasal-spraying LiveSpo Navax in Treatment of Influenza Virus in Children
Status: COMPLETED
Conditions: Acute Respiratory Tract Infections
Interventions: COMBINATION_PRODUCT: LiveSpo Navax|DRUG: 0.9% NaCl physiological saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity
Status: COMPLETED
Conditions: Osteoporosis|Excitability
Interventions: PROCEDURE: Forearm vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study the Safety and Effectiveness of MK7009 in Hepatitis C Infected Patients (MK-7009-004)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Comparator: MK7009|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Plasticity to Enhance Motor Retraining After Stroke
Status: COMPLETED
Conditions: Stroke|Cerebrovascular Accident|Hemiparesis
Interventions: PROCEDURE: Noninvasive neuromodulation via paired corticospinal-motoneuronal stimulation (PCMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: hAESCs Prevent Acute Graft-versus-host Disease After Hematopoietic Stem Cell Transplantation
Status: NOT_YET_RECRUITING
Conditions: Acute Graft Versus Host Disease
Interventions: BIOLOGICAL: Human amniotic epithelial stem cells（hAESCs）|BIOLOGICAL: placebo (cell preservation solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis (ASSET-IT)
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Intravenous thrombolysis plus tirofiban|DRUG: Intravenous thrombolysis plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Followed by Peripheral Stem Cell Transplantation Plus Biological Therapy in Treating Women With Stage IV Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: Ifosfamide, carboplatin, and etoposide (ICE) regimen|DRUG: Cyclophosphamide, Thiotepa, Carboplatin (CTC) or STAMP V (CTC)|PROCEDURE: Leukapheresis|PROCEDURE: peripheral blood stem cell transplantation (PBSCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radicular Cyst Enucleation Using Piezosurgery Versus Conventional Surgery
Status: COMPLETED
Conditions: RADICULAR CYSTS
Interventions: OTHER: PIEZOSURGERY VERSUS CONVENTIONAL SURGERY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients.
Status: ACTIVE_NOT_RECRUITING
Conditions: ER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancer|a Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI Status
Interventions: DRUG: Durvalumab|DRUG: Olaparib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Mechanical Ventilation for Guillain Barré Syndrome
Status: COMPLETED
Conditions: Guillain Barré Syndrome|Acute Respiratory Failure
Interventions: PROCEDURE: mechanical ventilation|PROCEDURE: physiotherapy and oxygen if needed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Before Surgery Compared With Chemotherapy Plus Radiation After Surgery in Treating Patients With Rectal Cancer That Can Be Surgically Removed
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Senescence and the Early Ageing Phenotype After Chemotherapy for Testicular Cancer: the SEA-CAT Study
Status: RECRUITING
Conditions: Testicular Cancer
Interventions: DIAGNOSTIC_TEST: Skin biopsy|DIAGNOSTIC_TEST: Subcutaneous fat biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of ADS-5102 in Patients With Multiple Sclerosis and Walking Impairment
Status: COMPLETED
Conditions: Walking Impairment|Multiple Sclerosis
Interventions: DRUG: ADS-5102|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Study of CM326 in Patients With Moderate-to-severe Atopic Dermatitis
Status: UNKNOWN
Conditions: Moderate-to-severe Atopic Dermatitis
Interventions: BIOLOGICAL: CM326|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tislelizumab (BGB-A317) Plus Chemoradiotherapy Followed by Tislelizumab Monotherapy in Newly Diagnosed, Stage III Subjects With Locally Advanced, Unresectable Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Tislelizumab|DRUG: Concurrent chemoradiotherapy (cCRT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Status: RECRUITING
Conditions: Refractory Epilepsy|Deep Brain Stimulation
Interventions: OTHER: PS and OS stimulation order 1|OTHER: PS and OS stimulation order 2|OTHER: PS and OS stimulation order 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: DRUG: Glimepiride|DRUG: Sitagliptin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Chidamide Combines With VP-16 and Methylprednisolone in the Treatment of HLH
Status: UNKNOWN
Conditions: Chidamide|Hemophagocytic Lymphohistiocytosis
Interventions: DRUG: Chidamide combines with VP-16 and methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Treatment Strategy for Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Arm A: FOLFIRI or FOLFOX + Bevacizumab|DRUG: Arm B: FOLFIRI or FOLFOX|DRUG: Arm D: FOLFIRI or FOLFOX plus CETUXIMAB|DRUG: Arm F: FOLFIRI or FOLFOX plus BEVACIZUMAB and CETUXIMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Define the Benefits and Harms of Deceased Donor Kidney Procurement Biopsies
Status: COMPLETED
Conditions: Kidney Transplant|Renal Transplant
Interventions: DIAGNOSTIC_TEST: Procurement Biopsy: Frozen section|DIAGNOSTIC_TEST: Procurement Biopsy: Permanent section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Methodology and Clinical Value of RIT in Intestinal Obstructive Diseases Mediated by Colonic TET
Status: UNKNOWN
Conditions: Fecal Microbiota Transplantation|Bowel Obstruction
Interventions: DIAGNOSTIC_TEST: retrograde image by colonic TET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of Respiratory Infections and MAnagement Among Children (PRIMAKid)
Status: COMPLETED
Conditions: Recurrent Upper and Lower Respiratory Tract Infections (RTIs)
Interventions: BIOLOGICAL: trivalent inactivated influenza vaccine|BIOLOGICAL: combined heptavalent pneumococcal conjugate vaccine and trivalent inactivated influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Endurant Stent Graft System Post Approval Study (ENGAGE PAS)
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal
Interventions: DEVICE: Endurant Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Brain Stimulation on Dual-task Gait Performance in PD
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: PROCEDURE: Deep brain stimulation with high frequency|PROCEDURE: Deep brain stimulation with low frequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine in Thoracoscopic Surgery: Opioid-Sparing Strategy
Status: COMPLETED
Conditions: Opioid Use|Postoperative Pain
Interventions: DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Strength Training and Protein Ingestion in Old Versus Very-old
Status: COMPLETED
Conditions: Sarcopenia|Muscle Loss
Interventions: PROCEDURE: Heavy Resistance Training|PROCEDURE: Light Intensity Training|PROCEDURE: Protein Whey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis (UC)
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: OTHER: Fecal Microbiota Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot-trial of Emotion-focused Cognitive Behavior Therapy for Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Delusional Disorder|Schizoaffective Disorder|Brief Psychotic Disorder|Schizophreniform Disorder
Interventions: BEHAVIORAL: CBT-E|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Web-based Nursing Intervention in the Reduction of Postpartum Depression and Parenting Stress.
Status: COMPLETED
Conditions: Depression, Postpartum
Interventions: BEHAVIORAL: standardized electronic messages|BEHAVIORAL: nurse phone call if requested|BEHAVIORAL: Staff nurse phone follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Salicornia for Neurovascular Health Improve
Status: RECRUITING
Conditions: Stroke|Ischemic Stroke|Neurovascular Injury|Brain Ischemia
Interventions: DIETARY_SUPPLEMENT: Food supplement based on Salicornia extracts|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study of Laparoendoscopic Single Site Surgical Staging for Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: PROCEDURE: single-port laparoscopic surgical staging|PROCEDURE: Four-port laparoscopic surgical staging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Re-Prosper HF Study
Status: RECRUITING
Conditions: Heart Failure
Interventions: DRUG: probenecid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Mild Hypertension Study (TOMHS)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases
Interventions: BEHAVIORAL: diet, sodium-restricted|BEHAVIORAL: diet, reducing|BEHAVIORAL: exercise|BEHAVIORAL: alcohol restriction|DRUG: chlorthalidone|DRUG: acebutolol|DRUG: doxazosin|DRUG: amlodipine|DRUG: enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Arthroscopic Shoulder Surgery
Status: COMPLETED
Conditions: Arthroscopic Shoulder Surgery
Interventions: PROCEDURE: Erector Spinae Plane (ESP) Block|PROCEDURE: Periarticular Infiltration (PAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Ultrasound-guided Insertion on Peripheral Catheters Related Complications.
Status: UNKNOWN
Conditions: Catheter Related Complication
Interventions: PROCEDURE: Traditional Peripheral venous catheter insertion|PROCEDURE: Ultrasound-guided insertion of a peripheral venous catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Intensive Smoking-cessation Intervention Versus Smoking-cessation Advice in Smear-positive Patients With Pulmonary Tuberculosis
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: nicotine replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Critical Illness|Starvation
Interventions: OTHER: Withholding PN during the first week of ICU stay|DRUG: Oliclinomel N71000 OR N71000E // Clinimix N17G35 OR N17G35E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Endurance Exercise on Breast Milk Composition in Women With Overweight/Obesity
Status: RECRUITING
Conditions: Breast Milk Collection|Overweight and Obesity
Interventions: BEHAVIORAL: Moderate intensity exercise|BEHAVIORAL: High intensity exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Voriconazole Compared With Itraconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: itraconazole|DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Edupression.Com® in Depressive Patients
Status: COMPLETED
Conditions: Depressive; Episode, Major|Recurrent Depressive Disorder, Current Episode Moderate|Recurrent Depressive Disorder, Current Episode Mild
Interventions: OTHER: edupression.com®|OTHER: Health tips|DIAGNOSTIC_TEST: Surveys|OTHER: Popular psychological interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Spinal Cord Stimulation on Sensory Perceptions of Chronic Pain Patients
Status: COMPLETED
Conditions: Chronic Pain|Complex Regional Pain Syndrome|Failed Back Surgery Syndrome
Interventions: DEVICE: Spinal cord stimulator|PROCEDURE: Implantation of a spinal cord stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ORCHARD- Optimising Home Assessment of Rural Patients
Status: NOT_YET_RECRUITING
Conditions: Organ Transplant|Cancer|Inborn Errors of Metabolism|Immunosuppression|COPD Asthma|Sickle Cell Disease
Interventions: DEVICE: A sphygmanometer, a digital thermometer, a pulse oximeter and a peak flow meter will be given to participants to use during their telemedicine consultations with health care providers.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of BC3402 in Combination With Azacitidine in Patients With MDS and CMML
Status: RECRUITING
Conditions: Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia
Interventions: DRUG: BC3402|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study to Compare Smoflipid and Intralipid 20% in Pediatric Patients of 3 Months to 16 Years of Age
Status: TERMINATED
Conditions: Malnutrition, Child
Interventions: DRUG: Smoflipid|DRUG: Intralipid, 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Recovery With Tart Cherry Supplementation Following a Marathon.
Status: COMPLETED
Conditions: Exercise Recovery
Interventions: DIETARY_SUPPLEMENT: Tart Cherry|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Application of Probiotic PS128 in Children With ASD
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: BIOLOGICAL: probiotics PS128|DRUG: placebo (Microcrystalline cellulose )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Sedation With Dexmedetomidine
Status: UNKNOWN
Conditions: Conscious Sedation
Interventions: DRUG: Dexmedetomidine|OTHER: Placebo - Concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Arzoxifene With Raloxifene in Women After Menopause With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: Arzoxifene|DRUG: Raloxifene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Blueberries on Uric Acid and Quality of Life
Status: COMPLETED
Conditions: Hyperuricemia
Interventions: DIETARY_SUPPLEMENT: Blueberry Powder|OTHER: Placebo Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telerehabilitation Dual-Task Training for Parkinson's: A Multidimensional Evaluation
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Cognitive-Motor Dual Task Activities|OTHER: Motor-Motor Dual Task Activities|OTHER: Cognitive-Motor & Motor-Motor Dual Task Activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
Status: RECRUITING
Conditions: Post-COVID-19 Syndrome
Interventions: DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Topical Sesame Oil in Preventing Phlebitis at IV Cannula Sites in Adults
Status: COMPLETED
Conditions: Phlebitis|Thrombophlebitis
Interventions: OTHER: Topical Sesame Oil|OTHER: Liquid paraffin oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Women With Acute Coronary Syndromes and Nonobstructive Coronary Artery Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndromes
Interventions: PROCEDURE: Intravascular ultrasound|PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Venetoclax-Obinutuzumab +/- Acalabrutinib in R/R CLL
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Venetoclax|DRUG: Obinutuzumab|DRUG: Acalabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Zinc and Iron From a Whey-based Protein Supplement Consumed With a Habitual Plant-based Diet
Status: COMPLETED
Conditions: Nutritional Deficiency
Interventions: DIETARY_SUPPLEMENT: Study 1: Whey Supplement Day 1|DIETARY_SUPPLEMENT: Study 1: Whey Supplement Day 2|DIETARY_SUPPLEMENT: Study 2: Whey Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Pharmacokinetics and Safety of Alefacept in Caucasian and Japanese Healthy Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics of Alefacept
Interventions: DRUG: alefacept|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Neo RQI: The Effect of Neonatal Resuscitation Quality Improvement Cart Booster Training Skills Retention
Status: COMPLETED
Conditions: Ventilatory Failure
Interventions: BEHAVIORAL: Booster Training with the Neonatal Resuscitation Quality Improvement Cart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Preoperative and Postoperative Incentive Spirometry in Patients Undergoing Major Abdominal Surgery
Status: TERMINATED
Conditions: Abdominal Surgery
Interventions: DEVICE: MIR Spirobank G|DEVICE: ZEPHYRx®|DEVICE: Conventional spirometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multiple-dose Pharmacokinetics of Ceftaroline During Continuous and Intermittent Renal Replacement Therapy in Patients Requiring Renal Replacement Therapy
Status: UNKNOWN
Conditions: Infection During Renal Replacement Therapy
Interventions: OTHER: Ceftaroline in CRRT|OTHER: Ceftaroline in IRRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Pharmacogenetic Testing Panel in Patients Suspected to be at Increased Risk for Pharmacogenetics-related AEs While Receiving Fluoropyrimidine or Irinotecan Therapy
Status: RECRUITING
Conditions: Cancer
Interventions: GENETIC: DPYD or UGT1A1 variants
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Lopinavir/Ritonavir Tablets Versus Soft Gel Capsules and Once Daily Versus Twice Daily Administration, When Coadministered With Nucleoside Reverse Transcriptase Inhibitors in Antiretroviral Naive Human Immunodeficiency Virus Type 1 Infected Subjects
Status: COMPLETED
Conditions: Human Immunodeficiency Virus Infections
Interventions: DRUG: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs)|DRUG: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs)|DRUG: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs)|DRUG: lopinavir/ritonavir (LPV/r) (tablet or capsule) with nucleoside reverse transcriptase inhibitors (NRTIs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Idelalisib in Combination With Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia With 17p Deletion
Status: TERMINATED
Conditions: B-cell Chronic Lymphocytic Leukemia (CLL) With 17p Deletion
Interventions: DRUG: Idelalisib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Psoriasis Treatment of Etanercept Combined Methotrexate
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: etanercept combined with methotrexate or etanercept combined with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1/1b Study to Evaluate the Safety and Tolerability of Ciforadenant Alone and in Combination With Atezolizumab in Advanced Cancers
Status: COMPLETED
Conditions: Renal Cell Cancer|Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: Ciforadenant|DRUG: Ciforadenant|DRUG: Ciforadenant|DRUG: Ciforadenant + atezolizumab|DRUG: Ciforadenant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Plus Toripalimab as First-line Treatment for Advanced Gastric Cancer With ECOG 2 (APICAL-GC)
Status: RECRUITING
Conditions: Gastric Cancer|Immunotherapy|Anlotinib|Toripalimab
Interventions: DRUG: Anlotinib Plus Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ALG-020572 Drug to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Single Doses in Healthy Volunteers and Multiple Doses in CHB Subjects
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ALG-020572|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Are the "Cardiac Benefits" of Empagliflozin Independent of Its Hypoglycemic Activity? (ATRU-4).
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Empagliflozin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Radial and Focused Extracorporeal Shock-wave Therapies in Coccydynia
Status: COMPLETED
Conditions: Coccyx Injury
Interventions: DEVICE: ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topically Applied Bisphosphocin Nu-3 on Infected Diabetic Ulcers of Subjects With Type I or II Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetic Foot Infections
Interventions: DRUG: Bisphosphocin Nu-3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NEPHSTROM for Diabetic Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Kidney Disease
Interventions: BIOLOGICAL: Mesenchymal Stromal Cells|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Perturbation of Human Small Intestinal Colonic Permeability
Status: RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Ricinoleic Acid 750 mg|DIETARY_SUPPLEMENT: Ricinoleic Acid 1500 mg|DIETARY_SUPPLEMENT: Ricinoleic Acid 3000 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers.
Status: COMPLETED
Conditions: Varicose Ulcer
Interventions: DEVICE: Dressing|DEVICE: Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Post-placental Insertion of IUCD During Cesarean Delivery Versus 6 Week Post-Cesarean Insertion
Status: COMPLETED
Conditions: Mechanical Complication of Intrauterine Device
Interventions: DRUG: IUCD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: CYNK-101 in Combination With Trastuzumab and Pembrolizumab in Patients With Locally Advanced Unresectable or Metastatic HER2-Positive Gastric or Gastroesophageal Junction (G/GEJ) Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic HER2 Positive Gastroesophageal Junction Cancer
Interventions: BIOLOGICAL: CYNK-101|DRUG: Pembrolizumab|DRUG: Trastuzumab|DRUG: Recombinant Human Interleukin-2|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Mesna
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Neuropilates Classes in Chronic Stroke Patients: A Pilot Randomised Feasibility Study
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: Neuropilates online exercise class|PROCEDURE: Online generalised exercise class|PROCEDURE: Unsupervised home exercise programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of a Virtual 'Coping With Brain Fog' Intervention for Young Adults With Cancer
Status: UNKNOWN
Conditions: Cancer|Cognitive Dysfunction|Cognitive Impairment|Adolescents|Young Adults
Interventions: BEHAVIORAL: 'Coping with Brain Fog' program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Cardiomyopeptidin on Postoperative Ischemia-reperfusion Injury in Patients With Primary PCI
Status: UNKNOWN
Conditions: Survival Myocardial Area After Acute Myocardial Death|Left Ventricular Ejection Fraction
Interventions: DRUG: cardiomyopeptidin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of GSK1160724 In Healthy Volunteers
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK1160724|DRUG: Tiotropium bromide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT