pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain
Status: UNKNOWN
Conditions: Fibromyalgia|Whiplash|Chronic Pain
Interventions: BEHAVIORAL: Relaxation session|BEHAVIORAL: Neurocognitive test battery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prevention of Weight Gain in Early Psychoses
Status: COMPLETED
Conditions: Schizophreniform Disorder|Bipolar I Disorder|Bipolar II Disorder|Major Depressive Disorder|Substance-Induced Psychoses|Psychosis Not Otherwise Specified|Schizophrenia|Schizoaffective Disorder
Interventions: BEHAVIORAL: Behavioural Intervention for the Prevention of Weight Gain|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of New Transdermal Contraceptive Patch at End of Shelf Life and Currently Marketed EVRA at the Beginning of Shelf Life in Healthy Women
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: EVRA patch (NGMN+EE) (Treatment A) (Reference)|DRUG: High molecular weight polyisobutylene (HMW PIB) patch (NGMN+EE) (Treatment B) (Test)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Impact of Aromatherapy on the Delirium of Patients in Intensive Care Unit
Status: COMPLETED
Conditions: Intensive Care Unit Delirium
Interventions: OTHER: Blending of essential oils|OTHER: Apricot vegetable oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Osteogenic Potential of Cissus Quadrangularis Alveolar Ridge Distraction
Status: COMPLETED
Conditions: Distraction of Bone|Dental Implant
Interventions: DRUG: Cissus Quadrangularis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of HBM-based Education Program on Improve Knowledge and Behaviors
Status: COMPLETED
Conditions: Undernutrition|Stunting|Wasting|Underweight
Interventions: BEHAVIORAL: health nutrition education|BEHAVIORAL: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing DTP-HB-Hib by Disposable-Syringe Jet Injector To Vaccination By Needle And Syringe In Infants
Status: TERMINATED
Conditions: Immune Response to DTP-HB-Hib Vaccine
Interventions: BIOLOGICAL: DTP-HB-Hib vaccine|DEVICE: Disposable Syringe Jet Injector (DSJI)|OTHER: Needle & Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)
Status: UNKNOWN
Conditions: Antiplatelet Therapy|Hemorrhagic Infarction
Interventions: DRUG: Early aspirin Therapy|DRUG: Non-Early aspirin Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of 2 'Point of Care' Diagnostic Methods to Improve Detection and Treatment of Anaemia in African Children
Status: COMPLETED
Conditions: Anaemia
Interventions: DEVICE: Hemocue 210 meter|DEVICE: Copack HBCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of ATB1651 in Adults With Mild to Moderate Onchomycosis
Status: NOT_YET_RECRUITING
Conditions: Onychomycosis
Interventions: DRUG: ATB1651-102- Cohort 1|DRUG: ATB1651-102- Cohort 2|DRUG: ATB1651-102- Cohort 3|DRUG: ATB1651-102- Cohort 4|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Footbaths With Ginger Powder on Subjectively Perceived Quality of Sleep
Status: COMPLETED
Conditions: Nonorganic Insomnia
Interventions: OTHER: Ginger powder footbath|OTHER: Warm water only footbath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolomic Evaluation of the Impact of Acqua Rocchetta on the Skin of Healthy Patients.
Status: UNKNOWN
Conditions: Skin
Interventions: DIETARY_SUPPLEMENT: Water A|DIETARY_SUPPLEMENT: Water B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A New Operation for the Treatment for Long-standing Atrial Fibrillation
Status: COMPLETED
Conditions: Cardiovascular Disease
Interventions: PROCEDURE: Left Atrial Geometric Volume Reduction, Pulmonary Vein Island Isolation and Left Appendage Base Closure(selected patients)|PROCEDURE: Left Atrial Geometric Volume Reduction, Pulmonary Vein Island Isolation and Left Appendage Base Closure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Aspheric ReSTOR Intraocular Lens (IOL) After Routine Cataract Extraction
Status: COMPLETED
Conditions: Cataract Extraction|Refractive Surgery
Interventions: DEVICE: aspheric ReSTOR multifocal intraocular lens (IOL)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Medication Development in Alcoholism: Suvorexant Versus Placebo
Status: COMPLETED
Conditions: Alcohol Use Disorder (AUD)
Interventions: DRUG: Suvorexant 20 mg|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Registrational Trial to Compare Effectiveness of Two Digital Software Medical Devices as Adjunctive Oncology Treatment
Status: TERMINATED
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Stage I Lung Cancer AJCC v8|Stage II Lung Cancer AJCC v8|Stage III Lung Cancer AJCC v8
Interventions: DEVICE: Attune™|DEVICE: Cerena™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Remote Guided Caffeine Reduction
Status: COMPLETED
Conditions: Caffeine Dependence|Anxiety|Sleep Disturbance|Gastrointestinal Dysfunction|Sleep Initiation and Maintenance Disorders|Caffeine; Sleep Disorder|Caffeine|Caffeine-Induced Anxiety Disorder|Caffeine Withdrawal|Caffeine-Induced Sleep Disorder, Without Use Disorder|Caffeine Abuse|Insomnia|Anxiety Disorders|Sleep Disorder|Heartburn|Diarrhea
Interventions: BEHAVIORAL: Caffeine Reduction Manual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resistance-type Exercise Training in Postmenopausal Women Survivors of Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer Survivors|Postmenopause|Resistance Training
Interventions: OTHER: Prolonged resistance-type exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Laparoscopic Pectopexy and Laparoscopic Lateral Suspension Surgeries
Status: RECRUITING
Conditions: Patients With Pelvic Organ Prolapse|Pectopexy|Lateral Suspension|Pop-q|Pisq-12
Interventions: PROCEDURE: pectopexy|PROCEDURE: lateral suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: A Multinational Phase III Study of CS-8958 (MARVEL)
Status: COMPLETED
Conditions: Influenza, Human
Interventions: DRUG: CS-8958|DRUG: CS-8958|DRUG: oseltamivir phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of E3810 for Healthy Japanese Male (Under Fasting Condition)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: rabeprazole|DRUG: rabeprazole|DRUG: rabeprazole|DRUG: rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Esomeprazole|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Management of Etonogestrel Subdermal Implant-related Bleeding
Status: COMPLETED
Conditions: ESI-related Bleeding
Interventions: DRUG: Doxycycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EGFR-TKIs Combine Chemotherapy as First-line Therapy for Patients With Advanced EGFR Mutation-positive NSCLC
Status: UNKNOWN
Conditions: EGFR Gene Mutation
Interventions: DRUG: pemetrexed|DRUG: cisplatin|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block and Modified-Thoracolumbar Interfascial Plane Block Following Lumbar Spinal Surgery
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: OTHER: Erector spinae plane block (Group E)|OTHER: modified-thoracolumbar interfascial plane block (Group T)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Viral Specific T Cell Therapy for COVID-19 Related Pneumonia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Symptomatic COVID-19 Infection Laboratory-Confirmed
Interventions: BIOLOGICAL: SARS-CoV-2 Antigen-specific Cytotoxic T-lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunotherapeutic Activity of an Anti-PD-1 Antibody (Cemiplimab) in Participants With HIV-1 on Suppressive cART
Status: TERMINATED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Cemiplimab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Predictive Clinical Features for Response to Adjuvant Immunotherapy in Stage II,III and IV Resected Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: OTHER: Frequency and duration of response to adjuvant immunotherapy according to clinical features|OTHER: Frequency of each type of relapse (i. e. local, distant, unique or multiple) to adjuvant therapy according to clinical features|OTHER: Duration of relapse-free survival according to clinical features|OTHER: Duration of overall survival according to clinical features|OTHER: Overall response rate|OTHER: Frequency of adverse events according to clinical features
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Pilot Efficacy and Safety Study of ST101 in Essential Tremor
Status: COMPLETED
Conditions: Essential Tremor
Interventions: DRUG: ST101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Peer-facilitated, Recovery-focused Self-illness Management Program for First-episode Psychosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychotic Disorders
Interventions: BEHAVIORAL: Peer-facilitated, Recovery-based Self-illness-management programme|BEHAVIORAL: Psycho-education group|BEHAVIORAL: Treatment-as-usual only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluating the Efficacy and Safety of Pembrolizumab Plus Standard Chemotherapy in the Neoadjuvant Treatment of Local Advanced (LA) HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Neoadjuvant Therapy|Pembrolizumab
Interventions: DRUG: Pembrolizumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Nedaplatin|DRUG: Nab paclitaxel|DRUG: Docetaxel|DRUG: Liposomal paclitaxel|DRUG: Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Enhanced External Counterpulsation (EECP) on Subclinical Atherosclerosis
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DEVICE: Enhanced External Counterpulsation (EECP)|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority of Pharmacological Prevention Alone Versus Pancreatic Stents to Prevent Post-ERCP Pancreatitis
Status: UNKNOWN
Conditions: Pancreatitis
Interventions: DEVICE: Pancreatic Stent|DRUG: Indomethacin|DRUG: Isosorbide Dinitrate|DRUG: Ringer's lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Behavioral Plant-Based Dietary Intervention in Latinos
Status: NOT_YET_RECRUITING
Conditions: Obesity|Metabolic Disease
Interventions: BEHAVIORAL: Behavioral plant-based dietary intervention|BEHAVIORAL: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tomographic Evaluation of Pulpotomy in Young Permanent Teeth Using Human-treated Dentin Matrix
Status: COMPLETED
Conditions: Pulpotomy of Young Permanent Molars
Interventions: DRUG: human treated dentin matrix|DRUG: Mineral Tri-Oxide Aggregate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Breath Samples Collection Clinical Trial, for Development of the TERA BioStation T101, Intended for CoV-19 Exhalation Products Detection.
Status: UNKNOWN
Conditions: COVID-19
Interventions: DEVICE: BioStation T101 and TeraTube
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children
Status: COMPLETED
Conditions: Moderate, Deep Sedation
Interventions: DRUG: Ketamine IV 1mg/kg|DRUG: Ketamine IV 1.5mg/kg|DRUG: Ketamine IV 2mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Sleeve Gastroplasty With Endomina® for the Treatment of Obesity in Kidney Transplant Candidates
Status: RECRUITING
Conditions: Obesity, Morbid|End Stage Renal Disease|Kidney Transplantation|Endoscopic Sleeve Gastroplasty
Interventions: PROCEDURE: Endoscopic Sleeve Gastroplasty (ESG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma
Status: UNKNOWN
Conditions: Osteosarcoma
Interventions: DIETARY_SUPPLEMENT: Curcumin powder|DIETARY_SUPPLEMENT: Ashwagandha extract
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Effectiveness and Impact of the GlaxoSmithKline Biologicals' Malaria Vaccine- RTS, S/AS01E in Young Children in Sub-Saharan Africa
Status: RECRUITING
Conditions: Malaria|Malaria Vaccines
Interventions: PROCEDURE: Whole blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Early Neurophysiological Interventions in Acute Cerebral Lesions
Status: COMPLETED
Conditions: Stroke|Acute Stroke
Interventions: DEVICE: bihemispheric transcranial direct stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain of Injection of Lipuro Propofol in Children Aged 1-7 Years
Status: COMPLETED
Conditions: ASA 1-2 Requiring Intravenous Cannulation for General Anaesthesia
Interventions: DRUG: lipuro propofol|DRUG: standard formulation propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of COPD Treatments
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: LABA and the LAMA tiotropium (LABA-TIO)|DRUG: LABA and an ICS (LABA-ICS)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of 50 mg NYX-783 QD vs. Placebo in PTSD
Status: TERMINATED
Conditions: PTSD
Interventions: DRUG: NYX-783|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Variations in Ketone Metabolism
Status: RECRUITING
Conditions: Ketosis
Interventions: DIETARY_SUPPLEMENT: Ketone Supplement|BEHAVIORAL: Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale|BIOLOGICAL: Blood Draw|OTHER: Urine Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in OSA
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Excessive Sleepiness
Interventions: DRUG: JZP-110|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Substance Use Treatment Services to Decrease Dropout and Improve Outpatient Treatment Utilization in Emerging Adults
Status: ENROLLING_BY_INVITATION
Conditions: Substance Use Disorders
Interventions: BEHAVIORAL: Peer Recovery Support-Delivered Dropout Prevention enhancement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: PROCEDURE: REAL-A|PROCEDURE: REAL-C|PROCEDURE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of E7090 as Monotherapy and in Combination With Other Anticancer Agents in Participants With Estrogen Receptor Positive (ER+) and Human Epidermal Growth Receptor 2 Negative (HER2-) Recurrent/Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: E7090|DRUG: Fulvestrant|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palonosetron for the Treatment of Nausea and Vomiting in Terminally Ill Patients
Status: TERMINATED
Conditions: Nausea|Vomiting|Terminally Ill
Interventions: DRUG: Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Use of an Innovative Device for Therapeutic Adherence in Pediatric Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DEVICE: Symbicort Turbohaler plus Turbo+|DRUG: Symbicort Turbohaler without Turbo+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH)
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: Stannous fluoride|OTHER: Sodium monofluorophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Transfusion-Dependent β-Thalassemia (TDT)
Status: RECRUITING
Conditions: Beta-Thalassemia|Thalassemia|Genetic Diseases, Inborn|Hematologic Diseases|Hemoglobinopathies
Interventions: BIOLOGICAL: CTX001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial of L-Alanine and Placebo in Fructose Intolerance
Status: TERMINATED
Conditions: Dietary Fructose Intolerance
Interventions: DIETARY_SUPPLEMENT: supplemental L-alanine|DIETARY_SUPPLEMENT: Metamucil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Motivational Interview in the Treatment of Obesity and Overweight in Adolescents
Status: UNKNOWN
Conditions: Obesity
Interventions: BEHAVIORAL: Motivational Interview|BEHAVIORAL: Conventional Interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Adjuvant Sutent for Patients With High Risk Urothelial Carcinoma After Neoadjuvant Chemotherapy and Cystectomy
Status: TERMINATED
Conditions: Urothelial Carcinoma|Bladder Cancer
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AUTO-ACUSAR - Effects of Acupuncture on the Autonomic Nervous System in Seasonal Allergic Rhinitis Patients
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: OTHER: sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Atomoxetine Versus Placebo in Children With Attention Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Test of a Web-based Intervention to Promote Hearing Protector Use
Status: COMPLETED
Conditions: Noise-induced Hearing Loss
Interventions: BEHAVIORAL: Sampler of hearing protection devices|BEHAVIORAL: Static Web-based information|BEHAVIORAL: Interactive Web-based information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine Versus Fentanyl on Postoperative Analgesic Profile in Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Dexmedetomidine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E-cigarettes and Blood Vessel Function
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: OTHER: one time exposure to e-cig with nicotine|OTHER: one time exposure to e-cig without nicotine|OTHER: one time exposure to empty e-cig
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Selinexor and Docetaxel in Treating Patients With Recurrent or Metastatic Squamous Cell Lung Cancer
Status: WITHDRAWN
Conditions: Recurrent Squamous Cell Lung Carcinoma|Stage IV Squamous Cell Lung Carcinoma
Interventions: DRUG: Docetaxel|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Pazopanib in Combination With Chemotherapy in Gynaecological Tumors
Status: COMPLETED
Conditions: Primary Peritoneal Carcinoma|Tumor|Epithelial Ovarian Cancer|Uterine Disease|Cervix Diseases|Neoplasms, Ovarian|Cancer
Interventions: DRUG: pazopanib (GW786034)|DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thyroidectomy Using Ultrasonic Dissector: Is Superior Laryngeal Nerve Really Safe ?
Status: UNKNOWN
Conditions: Goiter
Interventions: DEVICE: Thyroidectomy using harmonic focus (r)|PROCEDURE: Conventional thyroidectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multidisciplinary Intervention In Chronic GVHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Stem Cell Transplant Complications|Graft Vs Host Disease|Coping Skills|Quality of Life
Interventions: BEHAVIORAL: Horizon Program|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mifepristone for Treatment of Uterine Fibroids
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: Mifepristone|DRUG: Mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fluzoparib Combined With Camrelizumab for Maintenance Treatment of Locally Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Camrelizumab|DRUG: Fluzoparib|DRUG: Cisplatin，Pemetrexed|DRUG: Cisplatin，Etoposide|DRUG: Carboplatin, Albumin Paclitaxel|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Three-Period Study to Investigate the Relative Bioavailability and Pharmacodynamic Profiles of a Zegerid 20mg Capsule, Zegerid 20mg Powder for Oral Suspension and Losec 20mg Capsule in Healthy Adult Volunteers Under Fasting Conditions
Status: COMPLETED
Conditions: Acid Reflux|Gastro Oesophageal Reflux Disease
Interventions: DRUG: Zegerid|DRUG: Losec
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Chronic Hepatitis C Infection in Adult Transplant Recipients
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: ombitasvir/paritaprevir/ritonavir and dasabuvir|DRUG: ombitasvir/paritaprevir/ritonavir|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Safety, Blood Levels, And Brain Receptor Occupancy Of GSK163090 Using PET Imaging In Healthy Males
Status: COMPLETED
Conditions: Healthy Subjects|Depressive Disorder and Anxiety Disorders
Interventions: DRUG: GSK163090
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)
Status: COMPLETED
Conditions: Heart Valve Diseases|Coronary Artery Disease
Interventions: DRUG: dexmedetomidine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Non-Pharmaceutical Intervention for Cirrhotic Cramps Reduction: The NICCles Trial
Status: COMPLETED
Conditions: Cirrhosis|Muscle Cramp|Ascites
Interventions: OTHER: Household Remedy|OTHER: Tap water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma|Soft Tissue Sarcoma
Interventions: BIOLOGICAL: Pembrolizumab|COMBINATION_PRODUCT: MK-0482 + Pembrolizumab|COMBINATION_PRODUCT: MK-4830 + Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age-Related Macular Degeneration|Choroidal Neovascularization
Interventions: DRUG: IBI-20089/Lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antifolate Effectiveness in Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Adjuvant Arthritis
Interventions: DRUG: Methotrexate|DIETARY_SUPPLEMENT: Folinic acid|DIETARY_SUPPLEMENT: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of ePRO on Quality of Life and Prognosis of Patients With Unresectable Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer Metastatic|Cancer
Interventions: BEHAVIORAL: electronic patient report outcome
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility of Targeted Bronchial Washing for Molecular Testing by Next Generation Sequencing in Early-stage Lung Cancer
Status: RECRUITING
Conditions: Lung Cancer
Interventions: DIAGNOSTIC_TEST: Ultarthin bronchoscopy with intratumoral washing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Transcutaneous Electric Nerve Stimulation (TENS) for the Treatment of Nocturnal Enuresis in Children
Status: COMPLETED
Conditions: Nocturnal Enuresis|Bedwetting
Interventions: DEVICE: transcutaneous electric nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-blind Study to Compare the Efficacy and Safety of Zonisamide and Carbamazepine as Monotherapy, in Newly Diagnosed Partial Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Zonisamide|DRUG: Carbamazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Continuous Positive Airway Pressure (CPAP) in Patients With Resistant Hypertension and Obstructive Sleep Apnea (OSA)
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Refractory Hypertension
Interventions: DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reiki Breast Surgery QOL Project for Women Undergoing Breast Surgery
Status: RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Medical Reiki|OTHER: Sham Reiki
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Glucagon Rescue of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes Treated With Volagidemab
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: Volagidemab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer
Status: COMPLETED
Conditions: Stage 0/1 Breast Cancer|Post Biopsy|Pre-surgery
Interventions: DRUG: IV/oral n-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin B Complex Improved Exercise Performance and Anti-fatigue
Status: COMPLETED
Conditions: Exercise Performance|Fatigue
Interventions: OTHER: Placebo|OTHER: EX plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Porphozym in the Treatment of Acute Attacks in AIP
Status: COMPLETED
Conditions: Acute Intermittent Porphyria
Interventions: DRUG: recombinant human porphobilinogen deaminase (Porphozym)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase I/IIA Study of CART19 Cells for Patients With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma
Status: COMPLETED
Conditions: B Cell Leukemia|B Cell Lymphoma
Interventions: BIOLOGICAL: CART-19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study Evaluating the Efficacy and Safety of Ociperlimab in Combination With Tislelizumab and Chemotherapy as First-line Treatment for Participants With Advanced Triple Negative Breast Cancer
Status: WITHDRAWN
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Ociperlimab|DRUG: Tislelizumab|DRUG: Paclitaxel|DRUG: Nab-paclitaxel|DRUG: Carboplatin|DRUG: Placebo|DRUG: Pembrolizumab|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Anlotinib in Patients With Advanced Non-small Cell Lung Cancer（ALTER0302）
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Anlotinib|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare the Bioavailability of ABT-335 and Rosuvastatin From ABT-143 Relative to That From the Co-administration of ABT-335 and Rosuvastatin Calcium
Status: COMPLETED
Conditions: Adverse Events|Pharmacokinetic
Interventions: DRUG: ABT-143|DRUG: ABT-335|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of CTP-543 in Adults With Moderate to Severe Alopecia Areata (THRIVE-AA1)
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: CTP-543 matching placebo|DRUG: CTP-543|DRUG: CTP-543
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia
Status: RECRUITING
Conditions: Post Operative Pain, Acute
Interventions: DRUG: Pregabalin 150mg|DRUG: Fentanyl 100 micrograms ampoule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Notched Noise Therapy for Suppression of Tinnitus
Status: ENROLLING_BY_INVITATION
Conditions: Tinnitus|Notched Noise Therapy
Interventions: COMBINATION_PRODUCT: Hearing Aid and Notched Noise Therapy|COMBINATION_PRODUCT: Hearing Aid and Broadband Noise|DEVICE: Hearing Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Inhibitor Monotherapy or Combined With Molecular Targeted Drugs / Locoregional Therapy in the Treatment of Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Immune Checkpoint Inhibitor Monotherapy or Combined With Molecular Targeting Drugs / Locoregional Therapy for Hepatocellular Carcinoma
Interventions: DRUG: Immune checkpoint inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Facial Aesthetic Treatment in Millennials
Status: COMPLETED
Conditions: Dermatological Non-Disease
Interventions: DRUG: Botox Cosmetic Injectable Product|DEVICE: Juvéderm Voluma XC|DEVICE: Juvéderm Volbella XC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Safety and Effectiveness of Growth Hormone With GHD, TS, CRF, SGA , ISS and PWS in Children
Status: RECRUITING
Conditions: Growth Hormone Deficiency|Turner Syndrome|Chronic Renal Failure|Small for Gestational Age|Idiopathic Short Stature
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cerebral Protection in Transcatheter Left Atrial Appendage Occlusion
Status: RECRUITING
Conditions: Atrial Fibrillation|Silent Stroke|Cognitive Impairment|Depression
Interventions: PROCEDURE: LAAC procedure with the use of transcatheter cerebral protection system|PROCEDURE: LAAC procedure without the use of transcatheter cerebral protection system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: MAKO Total Knee Artroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Device: Robotic MAKO total knee|DEVICE: FocusMotion knee brace|DEVICE: Fitbit tracking device|DEVICE: FocusMotion app
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)
Status: COMPLETED
Conditions: Spinal Stenosis, Lumbosacral Region
Interventions: DRUG: Sevoflurane|DRUG: TIVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Postoperative Pain Management on Uvulopalatopharyngoplasty Patients
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative|Obstructive Sleep Apnea-hypopnea Syndrome|Pain, Acute
Interventions: DRUG: Dinalbuphine sebacate|OTHER: Routine practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reconstruction of Upper Eyelid With a Newly Modified Cutler-Beard Technique With Tarsoconjunctival Graf
Status: COMPLETED
Conditions: Reconstructive Surgical Procedure
Interventions: PROCEDURE: 'Cutler-Beard modified with graft'
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Hip Fracture Study in Patients 65 Years or Greater
Status: COMPLETED
Conditions: Hip Fractures
Interventions: DRUG: VK5211|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of of HZBio1 in Healthy Subjects
Status: UNKNOWN
Conditions: Healthy Participants
Interventions: DRUG: HZBio1 0.96mg / kg|DRUG: HZBio1 3mg / kg|DRUG: HZBio1 6mg / kg|DRUG: HZBio1 9mg / kg|DRUG: HZBio1 12mg / kg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Social Relationships on Psychological Distress and Disease Progression in Patients With Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2|Psychological Distress
Interventions: BEHAVIORAL: Social relationships intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repigmentation Using Apremilast and Phototherapy In Diffuse VITILIGO
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: Apremilast|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment
Status: RECRUITING
Conditions: Hepatic Encephalopathy|Dysbiosis
Interventions: PROCEDURE: Fecal microbiota transplantation delivery through colonoscopy|DRUG: Fecal microbiota transplantation delivery through oral capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection
Status: UNKNOWN
Conditions: Chondromalacia|Osteoarthritis|Traumatic Arthritis
Interventions: DEVICE: CartiZol|DEVICE: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Viscous Lidocaine for Upper Gastrointestinal Endoscopy
Status: ENROLLING_BY_INVITATION
Conditions: Anesthetics, Local|Esophagogastroduodenoscopy
Interventions: DRUG: Viscous Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Ravidasvir + Danoprevir/r 12-week Oral Therapy in Treatment-Naive Non Cirrhotic G1 CHC Taiwan
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Ravidasvir|DRUG: Danoprevir|DRUG: Ritonavir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Atrial Fibrillation After Cardiac Surgery
Status: TERMINATED
Conditions: Atrial Fibrillation|Atrial Flutter|C.Surgical Procedure; Cardiac|Arrhythmias, Cardiac
Interventions: DEVICE: Medtronic SEEQ™ mobile cardiac telemetry system|OTHER: Usual Care|DEVICE: CardioSTAT (Icentia Inc.) cardiac rhythm monitoring device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone and Post-operative Analgesia During Anal Sphincter Sparing Procedures Under General Anaesthesia
Status: COMPLETED
Conditions: Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone
Interventions: PROCEDURE: Caudal block|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Naturalistic Trial of the Norwegian Sickness Absence Clinic. The NSAC Efficacy Study
Status: RECRUITING
Conditions: Musculoskeletal Disorder|Anxiety Disorders|Depression|Fatigue|Pain|Occupational Exposure|Work Related Stress|Workplace Bullying|Employment|Sickness Absence|Return to Work
Interventions: OTHER: NSAC - rapid|OTHER: NSAC - ordinary|OTHER: NSAC - active control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leuprolide Acetate 3.75 mg Depot Injection for Patients With Advanced Prostate Cancer
Status: COMPLETED
Conditions: Advanced Prostate Adenocarcinoma
Interventions: DRUG: Leuprolide Acetate 3.75 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop
Status: COMPLETED
Conditions: Sensorimotor Gait Disorder|Neurologic Ambulation Disorder|Gait, Drop Foot|Poststroke Hemiparesis|Post-Cerebrovascular Accident (CVA) Hemiparesis
Interventions: DEVICE: Ness L300|DEVICE: Ankle-foot orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Dacarbazine With or Without Genasense in Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: dacarbazine plus Genasense|DRUG: dacarbazine plus placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of The Therapeutic Benefits of Al-hijamah in Children With Beta Thalassemia Major
Status: UNKNOWN
Conditions: AL-Hijama in Thalassmia Major
Interventions: PROCEDURE: Al-hijamah|DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic Profiles and Food Effect of CS32582 Capsules
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: CS32582 capsule|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT