pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study to Determine the Safety and Tolerability of 2 Concentrations of QLS-101
Status: COMPLETED
Conditions: Sturge-Weber Syndrome (SWS)|Glaucoma|Glaucoma Congenital|Ocular Hypertension
Interventions: DRUG: QLS-101ophthalmic solution 1%|DRUG: QLS-101ophthalmic solution 2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Conventional and Hypofractionated IMRT in High-Risk Cervical Cancer Post-Radical Hysterectomy
Status: RECRUITING
Conditions: Uterine Cervical Neoplasms
Interventions: RADIATION: Conventional Fractionated IMRT|RADIATION: Hypofractionated IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of High Intensity Interval Training And Moderate Intensity Continuous Training In Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension|Life Style
Interventions: OTHER: High intensity interval training|OTHER: Moderate intensity continuous training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety, and Tolerability of Guselkumab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa (HS)
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Guselkumab dose 1|DRUG: Guselkumab dose 2|DRUG: Guselkumab dose 3|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study on the Effect of Complementary Methods as Supportive Interventions for Parents of Children With Cancer
Status: COMPLETED
Conditions: Anxiety|Stress|Mood|Coping
Interventions: BEHAVIORAL: Guided Imagery and Progressive Muscle Relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Shelf-Stable MDCF-2 for Children With Undernutrition
Status: RECRUITING
Conditions: Undernutrition
Interventions: DIETARY_SUPPLEMENT: Central kitchen-prepared version of MDCF-2|DIETARY_SUPPLEMENT: MDCF-2 shelf-stable foil pouch prototype with green banana powder|DIETARY_SUPPLEMENT: MDCF-2 shelf-stable foil pouch prototype with sweet potato|DIETARY_SUPPLEMENT: Freshly reconstituted MDCF-2 ingredients|DIETARY_SUPPLEMENT: Ready-to-use supplementary food (RUSF) arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Biomarker Modulation and the Inhibition of NKT1 Cells by Oral GRI-0621 in Patients With IPF
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: Tazarotene (GRI-0621)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DAR-901 TB Booster Vaccine to Prevent TB in Adolescents
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: DAR-901|BIOLOGICAL: Sterile saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pediatric Preventative Health Screenings - Obesity and Family-Centered Outcomes
Status: COMPLETED
Conditions: Obesity|Overweight|Blood Pressure|Hypercholesteremia|Diabetes
Interventions: BEHAVIORAL: Motivational interviewing to elicit PCO in pediatrics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EFFICACY AND SAFETY OF A SIMPLIFICATION STRATEGY BASED ON DOLUTEGRAVIR AND DARUNAVIR / COBICISTAT VS OPTIMIZED TREATMENT IN SUPPRESSED HIV-1-INFECTED PATIENTS CARRYING ARCHIVED MULTIDRUG RESISTANCE MUTATIONS
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Dolutegravir (DTG) plus Darunavir/cobicistat (DRV/cobi).|DRUG: Current ART
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jinhua Qinggan Granules in the Treatment of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: COMBINATION_PRODUCT: Jinhua Qinggan (JHQG) Granules, Traditional Chinese Medicine|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: QUILT-2.022 NANT-008 in Combination w/ 5-fluorouracil, Bevacizumab, Leucovorin & Oxaliplatin in Subjects With Pancreatic Cancer
Status: WITHDRAWN
Conditions: Pancreatic Adenocarcinoma Metastatic
Interventions: DRUG: NANT-008|DRUG: Fluorouracil Injectable Product|DRUG: Avastin Injectable Product|DRUG: Leucovorin Calcium Injection|DRUG: Eloxatin Injectable Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sonographic Assessment of Cricoid Pressure
Status: RECRUITING
Conditions: Aspiration; Gastric Contents, Anesthesia|Intubation Complication
Interventions: OTHER: Application of cricoid pressure|OTHER: Application of Left lateral paratracheal pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety and Efficacy of L-NAME and Midodrine to Increase MAP
Status: COMPLETED
Conditions: Orthostatic Hypotension|Spinal Cord Injury
Interventions: DRUG: L-NAME|DRUG: Midodrine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotoxin Therapy in Treating Children With Progressive or Recurrent Glioblastoma Multiforme or Anaplastic Astrocytoma
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: BIOLOGICAL: transferrin-CRM107
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study
Status: UNKNOWN
Conditions: Biliary Stricture|Pancreas Cancer|Cholangiocarcinoma|Bile Duct Cancer|Bile Duct Neoplasms Malignant|Bile Duct Neoplasms|Bile Duct Lesions|Bile Duct Obstruction|Bile Duct Diseases|Bile Duct Obstruction, Extrahepatic|Bile Duct Stenosi|Bile Duct Adenoma|Pancreatic Duct Stricture|Pancreatic Duct Stenosis|Pancreatic Duct Obstruction|Pancreatic Ductal Adenocarcinoma|Primary Sclerosing Cholangitis
Interventions: OTHER: Interobserver agreement or Interrater agreement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Comparison of Dostarlimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer, Non-Small Cell
Interventions: DRUG: Dostarlimab|DRUG: Pembrolizumab|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SpO2 Measurement Using a Smartwatch
Status: COMPLETED
Conditions: Hypoxia|Hypercapnia
Interventions: OTHER: Hypoxic gas mixture|OTHER: Hypercapnic and hypoxic gas mixture|OTHER: SpO2 measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Clinical Study to Investigate Visual Performance of a Hydrophobic Monofocal IOL After Bilateral Implantation
Status: COMPLETED
Conditions: Cataract|Lens Opacities
Interventions: DEVICE: Micropure 1.2.3.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Streamlining the Efficiency of PrEP Implementation
Status: COMPLETED
Conditions: HIV Prevention|HIV Preexposure Prophylaxis|Implementation
Interventions: OTHER: Direct-to-pharmacy oral PrEP refill visits
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information
Status: UNKNOWN
Conditions: Parkinson
Interventions: OTHER: Measure of the electrophysiological activity of the subthalamic nucleus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Non-small Cell Lung Cancer|Small-cell Lung Cancer|Small Cell Lung Carcinoma
Interventions: DRUG: ADI-PEG 20|DRUG: Gemcitabine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy
Status: TERMINATED
Conditions: High Grade Glioma|Diffuse Intrinsic Pontine Glioma|Bithalamic High Grade Glioma
Interventions: DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitric Oxide Bioavailability and Early Life Stress (NO-Stress)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Antioxidant cocktail|OTHER: Biopsy|OTHER: Placebo|DRUG: NMD; 0.4mg sub-lingual nitroglycerin spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Dapagliflozin for Weight Loss
Status: UNKNOWN
Conditions: PreDiabetes|Obesity, Morbid|Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin/Metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intraosseous Transcutaneous Amputation Prosthesis
Status: COMPLETED
Conditions: Traumatic Amputation of Lower Extremity
Interventions: DEVICE: Direct skeletal fixation of ITAP to lower limb amputees.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measuring the Effects of Complementary Therapies in Chronic Neuropathic Pain
Status: RECRUITING
Conditions: Neuropathic Pain
Interventions: BEHAVIORAL: Hypnosis|BEHAVIORAL: Open label placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
Status: RECRUITING
Conditions: Adenocarcinoma of the Rectum|Locally Advanced Rectal Adenocarcinoma|Rectal Adenocarcinoma|HER2 Positive Rectal Adenocarcinoma|Rectal Cancer
Interventions: DRUG: Trastuzumab|DRUG: Tucatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder|Tobacco Smoking|Tardive Dyskinesia|Parkinsonism
Interventions: DRUG: Varenicline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Exercise and Flu-like Symptoms Following Interferon Beta 1a Injections in Patients With Multiple Sclerosis?
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: RGX-314 Gene Therapy Pharmacodynamic Study for Neovascular Age-related Macular Degeneration (nAMD)
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration|Wet Macular Degeneration|Wet Age-related Macular Degeneration
Interventions: GENETIC: RGX-314
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrated Multi-omics Data for Personalized Treatment of Obesity-associated Fatty Liver Disease
Status: RECRUITING
Conditions: NAFLD|Obesity, Morbid|Comorbidities and Coexisting Conditions
Interventions: DIAGNOSTIC_TEST: To propose diagnostic tests for liver diseases before surgical decisions.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intercostobrachial Nerve Block (ICBN) for Tourniquet Pain: Is it Necessary?
Status: COMPLETED
Conditions: Nerve Block|Pain
Interventions: DRUG: Receive ICBN with ropivacaine|BEHAVIORAL: No ICBN block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Checklist Tool in Engaging Patients in the Discharge Planning Process
Status: COMPLETED
Conditions: Hospitalization|Malignant Neoplasm|Transitional Care Planning
Interventions: OTHER: Communication Intervention|OTHER: Questionnaire Administration|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Transvaginal Self-tailored Titanium-coated Polypropylene Mesh Procedure With Mesh-kit Procedure.
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: pelvic floor reconstructive surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sublingual Misoprostol and Tranexamic Acid in Pregnant Women With Twin Pregnancy Undergoing Cesarean Section
Status: UNKNOWN
Conditions: Cesarean Section Complications
Interventions: DRUG: Misoprostol|DRUG: TA|DRUG: placebo to misoprostol|DRUG: placebo to TA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of the Heart to Fill and Empty, and the Ability of the Heart Muscle to Relax Adequately in People With High Blood Pressure.
Status: COMPLETED
Conditions: Diastolic Dysfunction|Hypertension
Interventions: DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Oral Administration Study of ASP015K in Healthy Nonelderly Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics of ASP015K|Healthy Volunteer
Interventions: DRUG: peficitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treatment Success With the CoolLoop Cryoablation System
Status: RECRUITING
Conditions: Atrial Fibrillation|Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation|Arrhythmias, Cardiac|Cardiovascular Diseases|Heart Diseases
Interventions: DEVICE: CoolLoop® cryoablation system
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison of Islet Cell Transplantation With Medical Therapy for the Treatment of Diabetic Eye Disease
Status: WITHDRAWN
Conditions: Diabetic Retinopathy|Diabetic Macular Edema
Interventions: PROCEDURE: islet cell transplant|OTHER: Medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S-1/LV One Week on and One Week Off Regimen in Advanced Hepatocellular Carcinoma (HCC)
Status: UNKNOWN
Conditions: Carcinoma|Liver Diseases|Hepatocellular Carcinoma
Interventions: DRUG: S-1 combined with Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tear Lipid Layer Thickness With Emollient Eye Drops
Status: COMPLETED
Conditions: Dry Eye Syndromes
Interventions: DRUG: Refresh Optive|DRUG: Refresh Optive MEGA-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dental Implant Study Comparing Two Types of Metals Used for Dental Implants
Status: COMPLETED
Conditions: Tooth Replacement
Interventions: DEVICE: Zimmer Trabecular Metal Test Cylinder|DEVICE: Zimmer Titanium Test Cylinder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of NALIRIFOX in Combination With Radiation Therapy in People With Pancreatic Ductal Adenocarcinoma (PDAC)
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma
Interventions: DRUG: NALIRIFOX|COMBINATION_PRODUCT: AD-XRT and Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis
Status: WITHDRAWN
Conditions: Liver Cirrhosis|Ascites Hepatic
Interventions: BIOLOGICAL: Fresh Frozen Plasma (FFP)|BIOLOGICAL: Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases
Status: RECRUITING
Conditions: Breast Cancer|Brain Metastases, Adult
Interventions: DRUG: Olaparib|RADIATION: Stereotactic Radiosurgery|DRUG: Durvalumab|DRUG: Physicians Choice systemic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Potential of Dapagliflozin Plus Exenatide in Obese Insulin-resistant Patients
Status: TERMINATED
Conditions: Obesity|Diabetes Mellitus, Type 2
Interventions: DRUG: Dapagliflozin 10mg|DRUG: Exenatide 2 mg [Bydureon]|DRUG: Placebo Oral Tablet|DRUG: Placebo injection|DRUG: Insulin|DRUG: Metformin, if taken before
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants
Status: RECRUITING
Conditions: High Frequency Oscillation Ventilation|Extreme Prematurity|Lung Injury, Acute
Interventions: PROCEDURE: regular lung recruitment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease
Status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis|Systemic Sclerosis With Lung Involvement
Interventions: DRUG: Vixarelimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Inactivated Hepatitis A Vaccine in HIV-infected People
Status: RECRUITING
Conditions: Hepatitis A|Immunodeficiency|HIV Infections
Interventions: BIOLOGICAL: 2 doses of HAV|BIOLOGICAL: At least one dose of HAV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety of and Immune Response to a Tick-Borne Encephalitis Vaccine (LGT(TP21)/DEN4) in Healthy Adults
Status: COMPLETED
Conditions: Tick-Borne Encephalitis
Interventions: BIOLOGICAL: LGT(TP21)/DEN4|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of LUNG Stereotactic Adaptive Ablative Radiotherapy
Status: WITHDRAWN
Conditions: Lung Cancer|Lung Tumor
Interventions: RADIATION: Stereotactic Adaptive Ablative Radiotherapy at 50 Gy (Gray)|RADIATION: Stereotactic Adaptive Ablative Radiotherapy at 60 Gy (Gray)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skeletal and Cognitive Effects of Nutrition From Eggs
Status: COMPLETED
Conditions: Bone Health|Cognitive Health
Interventions: OTHER: Whole egg powder|OTHER: Whole milk powder|OTHER: Gelatin food product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Accelerating Newborn Survival in Ghana Through a Low-dose, High-frequency Health Worker Training Approach
Status: COMPLETED
Conditions: Stillbirth|Neonatal Death
Interventions: BEHAVIORAL: Low dose high frequency health worker training approach|BEHAVIORAL: Active Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Freeze-Dried MVA-BN® Lot Consistency Smallpox Trial
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: FD MVA-BN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac Disease
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: High Frequency Chest Wall Oscillation and Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: High Frequency Chest Wall Oscillation (HFCWO)|OTHER: Usual airway clearance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dinaciclib in Treating Patients With Stage III-IV Melanoma
Status: TERMINATED
Conditions: Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma
Interventions: DRUG: dinaciclib|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Taking Choline Supplements During Pregnancy for Improving Infant Brain Development
Status: COMPLETED
Conditions: Pregnancy|Child Development
Interventions: DRUG: Choline|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antiretroviral Treatment Guided by Proviral Genotype: Pilot Trial of Proof of Concept.
Status: UNKNOWN
Conditions: HIV-1-infection
Interventions: DRUG: Dolutegravir (DTG)|DRUG: Lamivudine (3TC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Sulfonylureas and Insulin Glargine Outpatient Therapy for Unstable Diabetes and Impending DKA
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Glipizide|DRUG: Glipizide and Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Deep Brain Stimulation (DBS) on Sleep Architecture in Patients With Movement Disorders
Status: COMPLETED
Conditions: Parkinson's Disease|Tremor|Dystonia
Interventions: OTHER: Alteration of DBS stimulator settings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Fulvestrant+Abemaciclib With Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancer
Status: RECRUITING
Conditions: ER-Positive Breast Cancer|HER2-negative Breast Cancer
Interventions: DRUG: Fulvestrant Run-In
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Value of Allen's Test Result in Elective Patients Undergoing Coronary Catheterization Through Radial Approach
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: coronary catheterisation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction
Status: TERMINATED
Conditions: Myocardial Infarction, Acute
Interventions: DRUG: Colchicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate Early Glatiramer Acetate Treatment in Delaying Conversion to Clinically Definite Multiple Sclerosis of Subjects Presenting With Clinically Isolated Syndrome
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Glatiramer Acetate (DB)|DRUG: Placebo|DRUG: Glatiramer Acetate (OL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the Sangvia Blood Collection System on Postoperative Infections in Orthopedic Patients
Status: COMPLETED
Conditions: Coxarthrosis
Interventions: PROCEDURE: Autologous blood transfusion|PROCEDURE: Allogeneic blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
Status: NOT_YET_RECRUITING
Conditions: Pleural Infection
Interventions: PROCEDURE: Saline Irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: StroCare - Optimised Cross-sectoral,Coordinated Treatment of Stroke Patients With Patient-orientated Outcome Measurement
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: optimized cross-sectoral, structured and coordinated treatment pathway that integrates a patient-centred outcome evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation
Status: RECRUITING
Conditions: Heart Block|CIED Related Infection|CIED-related Infections|Antibiotic Prophylaxis|Biomarkers
Interventions: DRUG: Ampicillin sulbactam 3 days|DRUG: Placebo 3 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Pursed Lip Breathing With and Without Mat Pilates Training in Obese Women
Status: COMPLETED
Conditions: Obese Women
Interventions: OTHER: Pursed lip Breathing along Mat Pilates|OTHER: pursed lip breathing without Mat Pilates Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravenous AMD3100 for Collection of Autologous Peripheral Blood Stem Cells in Patients With Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin|Hodgkin Disease
Interventions: DRUG: AMD3100|DRUG: G-CSF|PROCEDURE: Apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate and Long-term Effects of an Adaptation of the "Balloon-blowing Exercise"
Status: COMPLETED
Conditions: Healthy
Interventions: PROCEDURE: An adaptation of the "balloon-blowing" exercise|PROCEDURE: An adaptation of the "balloon-blowing" exercise for seven weeks, three times a week, at home
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome
Status: RECRUITING
Conditions: Lynch Syndrome
Interventions: DRUG: Acetylsalicylic acid lysinate 300 mg|DRUG: Placebo (for Aspirin 300)|DRUG: Acetylsalicylic acid lysinate 100 mg|DRUG: Placebo 100 (for Aspirin 100)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Care Transitions for Complex Patient - Cycle 1 and Cycle 2
Status: COMPLETED
Conditions: Asthma|Coronary Artery Disease|Diabetes|Hypertension|Congestive Heart Failure
Interventions: OTHER: Reports|OTHER: Reports and Notices|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparative Effectiveness of Targeted Therapy in RA Patients
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Adalimuab, Etanercept, Tocilizumab, or Abatacept|DRUG: Tofacitinib or Baricitinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Placebo|DRUG: JNJ-42847922
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TAC T-cells for the Treatment of Claudin 18.2 Positive Solid Tumors (TACTIC-3)
Status: RECRUITING
Conditions: Metastatic Solid Tumor
Interventions: BIOLOGICAL: TAC01-CLDN18.2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: 10 mg ilaprazole|DRUG: 40mg esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiac Resynchronization Therapy in Adult Congenital Heart Disease With Systemic Right Ventricle: RIGHT-CRT
Status: RECRUITING
Conditions: Congenital Heart Disease|Systemic Right Ventricle|Congenitally Corrected Transposition of the Great Arteries|Transposition of Great Vessels|Heart Failure Congenital
Interventions: DEVICE: CRT ON (biventricular pacing) / CRT OFF (inactive or univentricular pacing)|DEVICE: CRT OFF (inactive or univentricular pacing) / CRT ON (biventricular pacing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics, Safety, and Tolerability of Lumateperone Long-Acting Injectable in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Lumateperone Long-Acting Injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Rewetting Drops in Subjects With History and Current Complaint of Contact Lens-Related Dry Eye (CLDE)
Status: COMPLETED
Conditions: Contact Lens Dry Eye
Interventions: DRUG: azithromycin ophthalmic solution, 1%|DRUG: Visine® for Contacts®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure
Status: WITHDRAWN
Conditions: Acute Heart Failure
Interventions: DRUG: Sodium nitroprusside|DRUG: Dobutamine|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Randomized Double Blind Controlled-study to Assess the Potential of Methotrexate Versus Placebo to Improve and Maintain Response to Anti TNF- Alpha Agents in Adult Patients With Moderate to Severe Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Methotrexate|DRUG: Methotrexate Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Description of the Short-term Effects of KAFTRIO® by Continuous Monitoring With the PHEAL-CR-K Application in Real Life in Patients With Cystic Fibrosis Eligible for KAFTRIO® Treatment
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: OTHER: Kaftrio utilization in real life
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multiple-Vaccine Therapy in Treating Patients With Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: HLA-A*2402restricted URLC10, TTK, VEGFR1 and VEGFR2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PSMA PET Scan and mpMRI for Prostate Cancer Detection
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer Diagnosis
Interventions: DIAGNOSTIC_TEST: PSMA PET scan|OTHER: No PSMA PET|DRUG: 18F- DCFPyl Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Indomethacin Versus Nifedipine for Preterm Labor Tocolysis
Status: COMPLETED
Conditions: Obstetric Labor, Premature
Interventions: DRUG: Indomethacin|DRUG: Nifedipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Budesonide Rectal Aerosol Foam and Uceris® Rectal Aerosol Foam
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Budesonide|DRUG: Uceris
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study-evaluate Performance&Safety "Aer-O-Scope" in Colon of Low Risk Patients
Status: COMPLETED
Conditions: Colon Cancer|Rectal Cancer
Interventions: DEVICE: Aer-O-Scope Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder|Generalized Anxiety Disorder|Major Depressive Disorder
Interventions: BEHAVIORAL: Emotion Regulation Therapy - Attention Regulation (AR-ERT)|BEHAVIORAL: Supportive Psychotherapy (SPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study With Ga101-DHAP as Induction Therapy in Relapsed/Refractory DLBCL Patients
Status: TERMINATED
Conditions: Diffuse, Large B-Cell, Lymphoma
Interventions: DRUG: GA101_DHAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Toripalimab Combine With Rituximab for Treatment of Relapsed Refractory CD20 Positive Diffuse Large B-cell Lymphoma
Status: UNKNOWN
Conditions: Diffuse Large B-cell Lymphoma|Rituximab|Toripalimab
Interventions: DRUG: Toripalimab combine with Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plate Osteosynthesis Versus ESIN of Displaced Midclavicular Fractures
Status: COMPLETED
Conditions: Clavicle Fractures
Interventions: PROCEDURE: plate osteosynthesis|PROCEDURE: ESIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Free Fatty Acid (FFA-) Suppression on Myocardial Lipids and Function in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: acipimox|DRUG: Placebo Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Relationship of Lenalidomide With Tumor Flare Reaction and High Tumor Burden in Participants With Relapsed or Refractory Mantle Cell Lymphoma
Status: RECRUITING
Conditions: Lymphoma, Mantle-Cell
Interventions: DRUG: Lenalidomide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing a Natural Product Plus Bioadhesive Nanoparticle (BNP) Sunscreen
Status: COMPLETED
Conditions: Skin Cancer
Interventions: DRUG: Sunscreen|OTHER: UV Light
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Demonstrate the Relative Bioavailability of Diclofenac Sodium 50 mg Enteric-Coated Tablets
Status: COMPLETED
Conditions: Inflammation
Interventions: DRUG: Diclofenac Sodium 50 mg Tablets (Geneva Pharmaceuticals, Inc)|DRUG: Voltaren 50 mg Tablets (Geigy Pharmaceuticals)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Interaction Study - Effect of AZD5672 on the Pharmacokinetics of Digoxin
Status: COMPLETED
Conditions: Healthy Volunteers|Pharmacokinetics
Interventions: DRUG: AZD5672|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study of SHR-1210(Anti-PD-1 Antibody) Combination With Apatinib Versus Pemetrexed and Carboplatin in Subjects With KRAS Mutant Stage IV Non-squamous Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: NSCLC Stage IV|KRAS Gene Mutation|PD-1 Antibody|Chemotherapy Effect
Interventions: DRUG: SHR-1210|DRUG: Apatinib|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Aschistosoma Haematobiumspecific microRNAas a Tumor Marker for Early Diagnosis and Prognosis of Bilharzial Bladder Cancer in Eygpt
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer
Interventions: DIAGNOSTIC_TEST: urinary micro RNA detection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Real-Time CAD for Colonic Neoplasia: A RCT
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Neoplasms
Interventions: DEVICE: Real-Time Computer Aided Detection|PROCEDURE: Stanford Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Drug Interactions in Outpatients.
Status: SUSPENDED
Conditions: Polypharmacy|Outpatient|Drug Interaction|Adverse Drug Reaction
Interventions: DEVICE: Interax-AI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Administration of a Molecular Complex of Resins, Polysaccharides and Polyphenols in Irritable Bowel Syndrome.
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DEVICE: Colilen IBS|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung|Lung Cancer|Non-Small Cell Lung Cancer|Carcinoma, Esophageal|Malignant Pleural Mesotheliomas
Interventions: DRUG: Decitabine (DAC)|DRUG: Tetrahydrouridine (THU)|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-staining Efficacy of Anti-Discoloration System (ADS) Added to Chlorhexidine (CHX)
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Chlorhexidine gluconate with ADS|DRUG: Chlorhexidine gluconate without ADS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Pharmacodynamics of NPC-01/IKH-01; Effect of NPC-01/IKH-01 on Sexual Hormone Concentrations in Healthy Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: NPC-01|DRUG: IKH-01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sleep Technology Intervention to Target Cardiometabolic Health
Status: ACTIVE_NOT_RECRUITING
Conditions: Elevated Blood Pressure|Habitual Sleep Duration of Less Than or Equal to 7 Hours
Interventions: BEHAVIORAL: Sleep extension intervention|BEHAVIORAL: Health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Immediate Implant Placement and Early Implant Placement
Status: UNKNOWN
Conditions: Tooth Fractures|Tooth Diseases
Interventions: PROCEDURE: tooth extraction|PROCEDURE: Implant placement|PROCEDURE: Bone augmentation|PROCEDURE: Coronally repositioned flap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the E-Mobile Health Application on Postpartum Adaptation
Status: COMPLETED
Conditions: Postpartum Period|Pregnant Women|Adaptation|Mobile Applications
Interventions: BEHAVIORAL: E-Mobile Health Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: rTMS as an Intervention for Levodopa-induced Dyskinesia
Status: RECRUITING
Conditions: Dyskinesia, Drug-Induced|Parkinson Disease
Interventions: DEVICE: active TMS|DEVICE: sham TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reproductive Hormones During Sustained Administration of Kisspeptin
Status: RECRUITING
Conditions: Fertility Disorders|Hypothalamic Dysfunction
Interventions: OTHER: Kisspeptin 0.1|OTHER: Saline|OTHER: Kisspeptin 0.3|OTHER: Kisspeptin 1.0
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Healthy Adults With Mild Cognitive Impairment (MCI) and a 16-week Intervention With Mitocholine™, a Functional Food Ingredient
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Mitocholine™ or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Heat Therapy and Cardiometabolic Health in Obese Women
Status: COMPLETED
Conditions: Obesity|Polycystic Ovary Syndrome|Prehypertension|PreDiabetes|Cardiovascular Risk Factor|Metabolic Syndrome
Interventions: BEHAVIORAL: Heat therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Botox Versus Oxybutynin as First Line Treatment for the Poorly Compliant Pediatric Neurogenic Bladder
Status: COMPLETED
Conditions: Neurogenic Bladder
Interventions: DRUG: Oxybutynin|DRUG: Botulinum Toxin A injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of External Counter Pulsation on Coronary Artery Disease
Status: UNKNOWN
Conditions: Stable Chronic Angina|Coronary Artery Disease
Interventions: DEVICE: External Counter Pulsation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Entinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT