pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT
Status: RECRUITING
Conditions: Patent Ductus Arteriosus After Premature Birth
Interventions: DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the CollaRx Bupivacaine Implant Compared to the ON-Q Painbuster Following Abdominal Hysterectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine Collagen Sponge (CollaRx Bupivacaine Implant)|DRUG: ON-Q PainBuster Post-op Pain relief System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CPL-01 in the Management of Postoperative Pain After Bunionectomy
Status: RECRUITING
Conditions: Bunion
Interventions: DRUG: Local anesthetic injection of CPL-01|DRUG: Naropin, 0.5% Injectable Solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Block vs Morphine in Vertebral Fixation
Status: COMPLETED
Conditions: Vertebral Subluxation|Spine Disease|Spondylolisthesis
Interventions: PROCEDURE: Erector Spinae plane Block|DRUG: Patient controlled analgesia with intravenous morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacokinetics in AD Subjects and Healthy Subjects of Cutaneous Application of LEO 39652 Cream
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: LEO 39652 cream|DRUG: cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Bronchiolitis Obliterans Syndrome
Interventions: PROCEDURE: Pulmonary function testing|DRUG: FAM Therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Home Exercise for Individuals With Neurodegenerative Disease
Status: RECRUITING
Conditions: Neurodegenerative Diseases|Leukodystrophy|Ataxia|LBSL|Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)|Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation|Cerebellar Ataxia|Adrenomyeloneuropathy
Interventions: BEHAVIORAL: Home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-Blind, Paralleled Study Comparing Efficacy/Safety of Solifenacin to Tolterodine in Overactive Bladder Patients
Status: COMPLETED
Conditions: Urinary Bladder, Overactive
Interventions: DRUG: solifenacin succinate|DRUG: tolterodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of CAT-192 (Human Anti-TGF-Beta1 Monoclonal Antibody) in Patients With Early Stage Diffuse Systemic Sclerosis
Status: COMPLETED
Conditions: Systemic Sclerosis|Scleroderma
Interventions: DRUG: Human Anti-Transforming Growth Factor Beta-1 Monoclonal Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture
Status: COMPLETED
Conditions: Dupuytren's Contracture
Interventions: BIOLOGICAL: collagenase clostridium histolyticum|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalency Study of CM082 Tablet in Healthy Volunteers
Status: COMPLETED
Conditions: Advanced Malignant Solid Tumors
Interventions: DRUG: CM082 tablet (test product)|DRUG: CM082 tablet (reference product)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Precision and Accuracy Using the Teed Scoring System Versus the O'Neill Grading System
Status: ENROLLING_BY_INVITATION
Conditions: Otic Barotrauma|Pressure Injury|Ear Injury|Barotitis|Barotrauma
Interventions: DIAGNOSTIC_TEST: Otic Barotrauma Grading System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase II Clinical Study of Surufatinib Combined With Sintilimab in the Treatment of Advanced Gastric Cancer
Status: RECRUITING
Conditions: Gastric Adenocarcinoma
Interventions: DRUG: Surufatinib+Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Evaluation of Nebulized Dexmedetomidine and Nebulized Ketamine as a Premedication in Pediatric Surgeries
Status: COMPLETED
Conditions: Anesthesia Refusal
Interventions: OTHER: normal saline without drug|DRUG: Dexmedetomidine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of SI-B001+SI-B003± Chemotherapy in the Treatment of Locally Advanced or Metastatic Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: SI-B001|DRUG: SI-B003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors
Status: COMPLETED
Conditions: Glioma of Brain|Craniopharyngioma|Ependymoma|Germ Cell Tumor
Interventions: DRUG: Memantine|OTHER: Placebo|OTHER: Cognitive Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy
Status: RECRUITING
Conditions: Head and Neck Cancer
Interventions: COMBINATION_PRODUCT: ASP-1929 Photoimmunotherapy|DRUG: Physician's Choice SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
Status: RECRUITING
Conditions: Pruritus
Interventions: DRUG: Dupilumab|DRUG: Placebo|DRUG: Fexofenadine (loratadine if not available)|DRUG: Moisturizer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Awareness, Courage, and Love Intervention to Help Chinese Older Adults in the Post-pandemic Era
Status: NOT_YET_RECRUITING
Conditions: Loneliness|Depression|Anxiety|Social Connectedness|Subjective Well-being|Psychological Intervention|Older Adults
Interventions: BEHAVIORAL: The Awareness, Courage and Love Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Clinical Efficacy of JNJ-42756493 (Erdafitinib), A Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, In Asian Participants With Advanced Non-Small-Cell Lung Cancer, Urothelial Cancer, Esophageal Cancer Or Cholangiocarcinoma
Status: COMPLETED
Conditions: Neoplasm
Interventions: DRUG: Erdafitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The DAWN Antivirals Trial for Ambulatory COVID-19 Patients
Status: TERMINATED
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: Camostat|DRUG: Placebo|DRUG: Molnupiravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DRUG: Intradiscal rhGDF-5|OTHER: Water for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Head and Neck Squamous Cell Carcinoma|Melanoma|Cell Cancer, Squamous|Carcinoma, Squamous Cell
Interventions: DRUG: MEDI0562
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcutaneous Spinal Cord Stimulation in Healthy Subjects to Activate Central Pattern Generator
Status: COMPLETED
Conditions: Motor Activity
Interventions: DEVICE: Transcutaneous spinal cord stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of The Potential Effect That The Administration Of Food Or Antacid Medication May Have In The Oral Absorption Of Dacomitinib (PF-00299804)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: dacomitinib fasted|DRUG: dacomitinib fed|DRUG: dacomitinib+antacid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ecologically Valid Virtual Tasks vs Paper-pencil Methods in Cognitive Rehabilitation in Patients With Schizophrenia and Depression
Status: COMPLETED
Conditions: Schizophrenia|Depression|Cognitive Impairment
Interventions: BEHAVIORAL: Virtual environment rehabilitation|BEHAVIORAL: Paper-pencil rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application Value of Whole-procedure Optimization for Catheter Ablation of Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Pulmonary vein isolation plus superior vena cava isolation|PROCEDURE: PVI, superior vena cava isolation, and linear ablation of linear ablations of the mitral isthmus, roofline and posterior wall line of the left atrium, and cavotricuspid isthmus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bococizumab HIV Evaluation (B-HIVE) Study
Status: TERMINATED
Conditions: Dyslipidemia|Cardiovascular Disease
Interventions: DRUG: Bococizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography Using Fludeoxyglucose F 18 in Predicting Response to Treatment in Patients Who Are Receiving Rituximab and Combination Chemotherapy for Newly Diagnosed Non-Hodgkin's Lymphoma
Status: WITHDRAWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|PROCEDURE: positron emission tomography|RADIATION: fludeoxyglucose F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Modified Dose and Schedule of Recombinant Hepatitis B Vaccination in HIV-infected Adult Subjects
Status: UNKNOWN
Conditions: HIV Infection
Interventions: BIOLOGICAL: Hepavax-Gene|BIOLOGICAL: Hepavax-Gene|BIOLOGICAL: Hepavax-Gene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Assessment of Bortezomib (Alvocade ®) Efficacy and Safety in Newly Diagnosed Multiple Myeloma Patients
Status: WITHDRAWN
Conditions: Newly Diagnosed Multiple Myeloma
Interventions: DRUG: Bortezomib 3.5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
Status: NOT_YET_RECRUITING
Conditions: Respiratory Distress Syndrome|Preterm Pregnancy|Surfactant Deficiency Syndrome Neonatal
Interventions: PROCEDURE: Less invasive surfactant administration during high flow nasal cannula treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of C-Mac D Blade and Fastrach Laryngeal Mask Airway on Cervical Spine Motion Conditions
Status: COMPLETED
Conditions: Intubation Complication|Cervical Discopathy
Interventions: DEVICE: C-Mac D Blade|DEVICE: Fastrach LMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effects of Black Cumin and Turmeric Along With Quantum Acoustic Waves on Inflammatory Markers and Pain in Osteoarthritis.
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis
Interventions: COMBINATION_PRODUCT: Black cumin and turmeric with Quantum Acoustic Waves (QAW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Pilot Study of 99mTc-MIP-1404 SPECT/CT Imaging to Histology in Men With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 99mTc MIP 1404
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma
Status: SUSPENDED
Conditions: Glioblastoma|Gliosarcoma|Supratentorial Glioblastoma
Interventions: RADIATION: External Beam Radiation Therapy|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|RADIATION: Radiation Therapy|DRUG: Temozolomide|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya
Status: RECRUITING
Conditions: Tobacco Use Cessation|Tobacco Use
Interventions: BEHAVIORAL: Tobacco Use Cessation Counselling Sessions|DRUG: Bupropion|DRUG: Nicotine patch|DRUG: Nicotine lozenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB060-00-AB (VRC01), Administered Intravenously or Subcutaneously to Healthy Adults
Status: COMPLETED
Conditions: HIV Infection|Monoclonal Antibody, Human|HIV Antibodies|VRC01 Monoclonal Antibody|Neutralizing Antibody
Interventions: DRUG: VRC-HIVMAB060-00-AB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: PREVENTION
Clinical trial: QUILT-3.039: NANT Pancreatic Cancer Vaccine: Combination Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: nab-paclitaxel|BIOLOGICAL: bevacizumab|BIOLOGICAL: avelumab|BIOLOGICAL: ALT-803|BIOLOGICAL: aNK for Infusion|BIOLOGICAL: ETBX-011|BIOLOGICAL: GI-4000
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Culture Media Microdroplet Geometry With Different Oil Overlay and Its Effect on Embryonic Development.
Status: COMPLETED
Conditions: Embryonic Development|Infertility
Interventions: OTHER: GPS/LM|OTHER: SPL/LM|OTHER: GPS/PO|OTHER: SPL/PO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Immune Response to Sars-Covid-19 Vaccines in Haematological Patients: Prospective Single Center Study
Status: COMPLETED
Conditions: Hematologic Diseases
Interventions: BIOLOGICAL: IgG antibodies to Sars-Cov-2|BIOLOGICAL: QuantiFERON SARS-CoV-2 test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Subcostal Transversus Abdominus , Erector Spinae and Paravertebral Blocks Effects on Laparoscopic Cholecystectomy Cases
Status: COMPLETED
Conditions: Comparison|Evaluation
Interventions: OTHER: TAP Block group|OTHER: Paravertebral block group|OTHER: Erector spinae block group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing the Effectiveness of Communication Therapy in the North West (The ACT NoW Pilot Study)
Status: COMPLETED
Conditions: Speech or Language Impairment Following Stroke
Interventions: PROCEDURE: Speech and Language therapy for dysarthria and/or aphasia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: ECT
Clinical trial: Hip Activation vs. Hip Activation + Core Stabilization
Status: COMPLETED
Conditions: Movement, Abnormal|Lower Extremity Problem
Interventions: OTHER: Hip activation home exercise program|OTHER: Hip activation plus core stabilization home exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Epidural Versus a Fascia Iliaca Compartment Catheter After Hip Surgery
Status: WITHDRAWN
Conditions: Postoperative Pain
Interventions: PROCEDURE: Epidural catheter is used postoperatively|PROCEDURE: Fascia iliaca compartment catheter is used postoperatively
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of a Multidisciplinary Intervention in ICU Survivors at Risk for Psychological or Physical Morbidity
Status: NOT_YET_RECRUITING
Conditions: Post-Intensive Care Syndrome|Depressive Symptoms|Anxiety|Physical Disability|Posttraumatic Stress Symptom
Interventions: OTHER: Case-manager led multidisciplinary follow-up after intensive care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Urotherapy vs. Urotherapy With Constipation Treatment for Children With Lower Urinary Tract Dysfunction
Status: WITHDRAWN
Conditions: Diurnal Enuresis
Interventions: DRUG: polyethylene glycol 3350|BEHAVIORAL: Constipation behavioral therapy|BEHAVIORAL: Urotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimized Magnetic Resonance Brachytherapy (MR BT) in Cervix Cancer
Status: COMPLETED
Conditions: Cervix Cancer
Interventions: RADIATION: optimised magnetic resonance image-guided intra-uterine brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D Supplementation During a Non-surgical Treatment of Generalized Chronic Periodontitis
Status: UNKNOWN
Conditions: Generalized Chronic Periodontitis|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Microbial Growth on Bre-Flex Versus PEEK Denture Base in Bilateral Maxillary Bounded Partial Denture
Status: UNKNOWN
Conditions: Microbial Colonization
Interventions: OTHER: PEEK|OTHER: Breflex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety and Tolerability of Indacaterol Maleate/Mometasone Furoate Delivered Via the Twisthaler® Device After 14 Days Treatment in Patients With Mild to Moderate Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: indacaterol maleate / mometasone furoate|DRUG: placebo to indacaterol maleate/mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Safety and Immunogenicity of a Seasonal Influenza Virus-Like Particle (VLP) Vaccine in Older Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza VLP Vaccine|BIOLOGICAL: TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective NIS to Evaluate the Clinical Outcomes of Risarg® (Ribociclib) Combined With Endocrine Therapy or Chemotherapy in Patients With HR+HER2 - aBC in Routine Clinical Practice in the Russia
Status: RECRUITING
Conditions: HR+HER2- Advanced Breast Cancer
Interventions: OTHER: Ribociclib|OTHER: Combination chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety, Efficacy and Pharmacokinetics Study of CD11301 for the Treatment of Cutaneous T-Cell Lymphoma (CTCL)
Status: COMPLETED
Conditions: Cutaneous T Cell Lymphoma
Interventions: DRUG: Placebo|DRUG: CD11301 0.03%|DRUG: CD11301 0.06%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery
Status: RECRUITING
Conditions: Blood Pressure|Complication,Postoperative|Intraoperative Hypotension
Interventions: DRUG: Ephedrine|DRUG: Norepinephrine|DRUG: Etilefrine Hydrochloride bolus|DIAGNOSTIC_TEST: Use of pulse pressure and stroke volume variation (PPV and SVV); use of Mini Fluid Challenge (mini_FC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clock and Narcolepsy Genetic Variants and the Effects of Stalevo® (Levodopa/Carbidopa/Entacapone) on Sleep Disorders in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease|Sleep Disorders
Interventions: DRUG: Stalevo®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Neurostimulation of the Vagus Nerve for the Relief of Acute Bronchoconstriction Due to Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DEVICE: AlphaCore System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Feasibility Study on Pain Control After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: TAP Block|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Functional Diagnostic Accuracy of Quantitative Flow Ratio in Tandem Lesions and Virtual Stenting
Status: UNKNOWN
Conditions: Coronary Artery Disease|Cardiovascular Diseases|Myocardial Ischemia|Arterial Occlusive Diseases|Heart Diseases|Vascular Diseases|Arteriosclerosis
Interventions: DEVICE: Quantitative Flow Ratio (QFR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma
Status: RECRUITING
Conditions: Relapsed Classic Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sub-mental Sensitive Transcutaneous Electrical Stimulation on Pharyngeal Muscles Control : TENSVIRT Study
Status: COMPLETED
Conditions: Oropharyngeal Dysphagia|Deglutition Disorders
Interventions: DEVICE: Urostim 2 stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Stereotactic Radiotherapy (SRT) Liver (COLD 1)
Status: COMPLETED
Conditions: Liver Neoplasms|Neoplasm Metastases
Interventions: PROCEDURE: Stereotactic radiotherapy (SRT) or highly conformal (CRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Onset of Action of SKY0402 Following Local Infiltration in Healthy Volunteers
Status: COMPLETED
Conditions: Postoperative Pain Management
Interventions: DRUG: SKY0402|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Transcranial Direct Current Stimulation (tDCS) on Individuals With Prader-Willi Syndrome
Status: UNKNOWN
Conditions: Prader-Willi Syndrome|Obesity|Depressive Disorder|Obsessive-Compulsive Disorder
Interventions: DEVICE: tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Osteoarthritis|Systemic Lupus Erythematosus|Sjogren's Syndrome|Scleroderma|Spondylitis|Gout|Spinal Disease|Chondrocalcinosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-Related Disorders|Hepatitis C (HCV)|Human Immunodeficiency Virus (HIV)|Drug Overdose|Substance Abuse|Intravenous Drug Usage|Opiate Substitution Treatment|Sexually Transmitted Diseases
Interventions: BEHAVIORAL: Harm reduction kiosk
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SOLARIS Peripheral PMCF Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease|Iliac Artery Stenosis|Common Femoral Artery Stenosis
Interventions: DEVICE: Solaris Vascular Stent Graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder.
Status: COMPLETED
Conditions: Cancer|Cancer Pain
Interventions: DRUG: Morphine|DRUG: Fentanyl|DRUG: Buprenorphine|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Osimertinib+Bevacizumab+Chemotherapy for EGFR+ Advanced Non-Small Cell Lung Cancer With Concurrent Mutations
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Osimertinib|DRUG: Bevacizumab Biosimilar IBI305|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Infant Formula With Partially Hydrolized Whey
Status: WITHDRAWN
Conditions: Growth Failure
Interventions: DIETARY_SUPPLEMENT: partially hydrolyzed whey|DIETARY_SUPPLEMENT: Nan HA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Youth Compass Plus
Status: COMPLETED
Conditions: Psychological Flexibility|Psychological Well-being
Interventions: BEHAVIORAL: face-to-face support and Chatbot online support group|BEHAVIORAL: only chat-robot online support group|BEHAVIORAL: Control group, no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Divalproex Sodium 125 MG Delayed Release Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Seizures
Interventions: DRUG: Divalproex Sodium|DRUG: Depakote DR Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post-transplant Cyclophosphamide and Sirolimus Following Reduced Intensity Conditioning (RIC) Transplant
Status: COMPLETED
Conditions: Hematologic Neoplasms
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind Placebo-controlled Pilot Study of Sirolimus in Idiopathic Pulmonary Fibrosis (IPF)
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis|Diffuse Parenchymal Lung Disease|Interstitial Lung Disease
Interventions: DRUG: sirolimus|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Secondary Prevention of Small Subcortical Strokes Trial
Status: COMPLETED
Conditions: Cerebrovascular Accident|Hypertension
Interventions: DRUG: aspirin|DRUG: clopidogrel|OTHER: Target of Blood Pressure|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fasting or Non-fasting Before Cardiac Catheterization
Status: UNKNOWN
Conditions: Fasting|Coronary Artery Disease|Procedural Complication|Coronary Angiography
Interventions: OTHER: Advice on fasting before the procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of HPN536 in Patients With Advanced Cancers Associated With Mesothelin Expression
Status: COMPLETED
Conditions: Advanced Cancers Associated With Mesothelin Expression
Interventions: BIOLOGICAL: HPN536 Fixed IV 6 to 560 ng/kg|BIOLOGICAL: HPN536 1 Prime Step IV 600-1200 ng/kg Target|BIOLOGICAL: 2 Prime Step IV 900-14000 ng/kg Target
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Montefiore Metoclopramide Study
Status: COMPLETED
Conditions: Nausea|Extrapyramidal Symptoms
Interventions: DRUG: metoclopramide 10 mg|DRUG: Diphenhydramine 25 mg|DRUG: Placebo|DRUG: Metoclopramide 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: U-LABA/ICS Effects on Exercise Performance, Vilanterol
Status: RECRUITING
Conditions: Exercise Performance
Interventions: DRUG: Vilanterol and Fluticasone Furoate (low dose)|DRUG: Vilanterol and Fluticasone Furoate (high dose)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nano MRI on 7 Tesla in Rectal and Breast Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasms|Breast Neoplasms
Interventions: DRUG: ferumoxtran-10|DEVICE: 7 Tesla MRI|DEVICE: 3 Tesla MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease
Status: TERMINATED
Conditions: Mild Cognitive Impairment Due to Alzheimer's Disease
Interventions: DRUG: Pioglitazone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of SNF472 for Calciphylaxis
Status: COMPLETED
Conditions: Calciphylaxis|Calcific Uremic Arteriolopathy
Interventions: DRUG: Experimental: SNF472|DRUG: Placebo Comparator: Placebo|DRUG: Experimatenl SNF472 (Open-label)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve
Status: TERMINATED
Conditions: Heart Arrest
Interventions: DEVICE: Impedance Threshold Device (ITD)|DEVICE: Sham ITD|OTHER: Analyze early|OTHER: Analyze later
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Strict Need to Void After Same-day Discharge, Non-urogynecologic, Minimally Invasive Hysterectomy
Status: COMPLETED
Conditions: Urinary Retention Postoperative
Interventions: BEHAVIORAL: No Strict need to void following surgery|BEHAVIORAL: Strict need to void following surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Participants With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis (MS)
Interventions: DRUG: Ocrelizumab|DRUG: Ocrelizumab|DRUG: rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis
Status: SUSPENDED
Conditions: Crohn Disease|Ulcerative Colitis
Interventions: DRUG: Ustekinumab IV Infusion|DRUG: Ustekinumab SC Injection|DRUG: Midazolam 2 mg|DRUG: Warfarin 10 mg|DRUG: Vitamin K 10 mg|DRUG: Omeprazole 20 mg|DRUG: Dextromethorphan 30 mg|DRUG: Caffeine 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Touch on One Thumb, RSI on the Other Thumb: Which Surgery Shows Better Results
Status: COMPLETED
Conditions: Osteoarthritis Thumb|Joint Diseases|Musculoskeletal Diseases or Conditions|Osteoarthritis|Arthrosis of First Carpometacarpal Joint
Interventions: DEVICE: Touch® Prosthesis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigation of a Novel Positive Pressure Therapy to Rescue Patients Failing to Tolerate CPAP During an Initial Encounter
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: BiPap auto with Fi Flex|DEVICE: Standard CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture for Patients With Chronic Urinary Retention Secondary to Lower Motor Neuron Lesion
Status: UNKNOWN
Conditions: Chronic Urinary Retention
Interventions: OTHER: Electroacupuncture|OTHER: Sham electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Palliative Radiochemotherapy Against Palliative Surgery in Stage IV Rectal Cancer With Unresectable Metastases
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: RADIATION: short course of palliative radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Dexamethasone, and Rituximab in Previously Untreated Patients With Waldenstrom's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: Bortezomib, Rituximab, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Auto-Adjusting Positive Airway Pressure Devices
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: APAP A (ResMed AirSense AutoSet)|DEVICE: APAP B (Apex iCH Auto)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tissue-Specific Metabolic Reprogramming in Diabetic Complications
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: PROCEDURE: Euglycemic clamp (normal blood sugar clamp) for 4 hours|PROCEDURE: hyperglycemic clamp (elevated blood sugar to 300) for 4 hours
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vinorelbine and Gemcitabine Versus Capecitabine in Pretreated Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Capecitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Compare Triple Therapy (Oral Treprostinil, Ambrisentan, and Tadalafil) With Dual Therapy (Ambrisentan, Tadalafil, and Placebo) in Subjects With Pulmonary Arterial Hypertension
Status: WITHDRAWN
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Oral Treprostinil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial for an Evaluation of Choline Alfoscerate and Donepezil for Cognitive Improvements of Patients With Cerebrovascular Injury in Alzheimer Patients
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: DRUG: Choline alfoscerate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Technology and Motivational Interviewing in Type 2 Diabetes Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Gaming|Motivational Interviewing|Self-Management|Quality of Life|Mobile Technology
Interventions: BEHAVIORAL: Patient Education with Game-Based Mobile Technology and Motivational Interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: anastrozole|DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: docetaxel|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: pamidronate disodium|DRUG: thiotepa|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation With H-coil in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: rTMS with H-coil|DEVICE: Sham rTMS stimulation with H-coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Reduction of the Inferior Turbinates for Nasal Obstruction
Status: TERMINATED
Conditions: Chronic Rhinitis|Inflammation of the Nasal Mucosa|Inflammation of Nasal Tissue
Interventions: PROCEDURE: Surgical turbinate reduction procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) Treatment
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Kisspeptin 1.6nmol/kg|DRUG: Kisspeptin 3.2nmol/kg|DRUG: Kisspeptin 6.4nmol/kg|DRUG: Kisspeptin 9.6nmol/kg|DRUG: Kisspeptin 12.8nmol/kg|DRUG: Kisspeptin 9.6 nmol/kg double|DRUG: Kisspeptin 9.6 nmol/kg + saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BI 1744 CL in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1744 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: E-intervention on Subclinical Fear of Cancer Recurrence
Status: RECRUITING
Conditions: Cancer|Psychooncology|Fear of Cancer Recurrence
Interventions: BEHAVIORAL: eConquerFear-HK|BEHAVIORAL: Basic Cancer Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACT-smart: Smartphone-supplemented iCBT for Social Phobia and/or Panic Disorder
Status: COMPLETED
Conditions: Panic Disorder|Phobic Disorders
Interventions: BEHAVIORAL: Smartphone-supplemented iCBT|BEHAVIORAL: Therapist support|OTHER: Active waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Safety and Systems Biology Response of Ebolavirus Zaire Vaccine (ChAd3-EBO-Z)
Status: COMPLETED
Conditions: Ebola Disease|Immunisation
Interventions: BIOLOGICAL: ChAd3-EBO-Z|BIOLOGICAL: MVA Multi-Filo Ebola Vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
Status: RECRUITING
Conditions: Metastatic Undifferentiated Pleomorphic Sarcoma|Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8|Unresectable Undifferentiated Pleomorphic Sarcoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Diagnostic Imaging|DRUG: Doxorubicin|PROCEDURE: Echocardiography|PROCEDURE: Multigated Acquisition Scan|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does UROSHIELD® Influence Bacterial Growth On Endotracheal Tubes
Status: UNKNOWN
Conditions: Mechanical Ventilation Complication
Interventions: DEVICE: UROSHIELD®|DEVICE: SHAM UROSHIELD®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immune Response of an Interchangeable Booster Vaccine Against COVID-19 Among Individuals With Risk Factors for Severity
Status: UNKNOWN
Conditions: Comorbidities and Coexisting Conditions|Healthy
Interventions: OTHER: Vaccine - ChAdOx1-S/nCoV-19 [recombinant]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Botulinum Toxin Injection Into Upper Esophageal Sphincter in Patients With Medullary Infarction
Status: RECRUITING
Conditions: Brain Stem Infarctions|Dysphagia, Oropharyngeal|Dysphagia, Esophageal
Interventions: DRUG: Botulinum toxin type A for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supracondylar Pinning Antibiotic Stewardship (SPAS) Trial
Status: UNKNOWN
Conditions: Supracondylar Humerus Fracture|Infection
Interventions: DRUG: Cefazolin|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections
Status: NOT_YET_RECRUITING
Conditions: Anesthesia; Adverse Effect, Spinal and Epidural
Interventions: DRUG: Granisetron 1 Mg/mL Intravenous Solution|DRUG: Pethidin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% to LUMIGAN® In The Treatment of Chronic Open-Angle Glaucoma
Status: COMPLETED
Conditions: Glaucoma, Open-Angle
Interventions: DRUG: Test - Bimatoprost 0.01% Ophthalmic Solution|DRUG: Reference - LUMIGAN® (Bimatoprost 0.01% Ophthalmic Solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT