pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of Transdermal Nicotine, on Motor Symptoms in Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: Transdermal nicotine|OTHER: Usual drug treatment of Parkinson's disease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positional Release Technique in Patients With Unilateral Subacute Trapezitis
Status: COMPLETED
Conditions: Cervical Spine Disease
Interventions: OTHER: Positional release technique|OTHER: Myofascial release technique & Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study Of Sunitinib In Combination With Pemetrexed In Patients With Advanced Solid Malignancies
Status: COMPLETED
Conditions: Neoplasm, Malignant
Interventions: DRUG: Sunitinib, Pemetrexed|DRUG: Sunitinib, Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dovitinib Lactate, Gemcitabine Hydrochloride, and Capecitabine in Treating Patients With Advanced or Metastatic Solid Tumors, Pancreatic Cancer and Biliary Cancers
Status: COMPLETED
Conditions: Adenocarcinoma of the Pancreas|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: dovitinib lactate|DRUG: gemcitabine hydrochloride|DRUG: capecitabine|OTHER: laboratory biomarker analysis|OTHER: enzyme-linked immunosorbent assay|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Matão Controlling Hypertension (MatCH Study): Rationale and Design
Status: UNKNOWN
Conditions: Hypertension|Blood Pressure
Interventions: DRUG: Captopril 25Mg, Hydrochlorothiazide 25Mg Oral Tablet,|DRUG: Atenolol|DRUG: Losartan potassium 50mg|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression
Status: TERMINATED
Conditions: Post Partum Depression
Interventions: DRUG: Ketamine 0.5 mg/kg|DRUG: Ketamine 0.2 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Series of N-of-1 Trials of Traditional Chinese Medicine Based on Bayesian Method
Status: UNKNOWN
Conditions: Bronchiectasis|Quality of Life|Traditional Chinese Medicine|Sputum|Symptoms|Individuality
Interventions: DRUG: Individualized Decoction|DRUG: placebo|DRUG: Tested drug minus heat-clearing herbs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CHF COPD Sip Feed Anabolic Response
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive|Congestive Heart Failure
Interventions: OTHER: sip feeding with stable isotope infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Vitamin K 2 on Vascular Calcification in Hemodialysis Patients
Status: UNKNOWN
Conditions: End Stage Renal Disease
Interventions: DRUG: Vitamin K2|DRUG: Cholecalciferol (inactive vitamin D)|DRUG: Vitamin K2 and Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Follow-Up Study of Schizophrenic Participants Following Treatment Discontinuation After Remission From a First Psychotic Episode
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Oral risperidone|DRUG: Risperidone Long-Acting Injection (RLAI)|DRUG: Risperidone Long-Acting Injection (RLAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FFAR Agonist on Incretins, Insulin, Lipids and Inflammation
Status: COMPLETED
Conditions: Type2 Diabetes Mellitus|Obesity
Interventions: DIETARY_SUPPLEMENT: Pine nut oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Health Effects of Flavanol Rich Chocolate
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: High flavanol chocolate|DIETARY_SUPPLEMENT: Low flavanol chocolate|DIETARY_SUPPLEMENT: High fat challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study to Evaluate the Safety and Tolerability of PRO-231 Ophthalmic Solution Versus VIGAMOXI® on the Ocular Surface of Healthy Subjects.
Status: RECRUITING
Conditions: Ophthalmological Agent Toxicity|Bacterial Conjunctivitis
Interventions: DRUG: PRO-231|DRUG: VIGAMOXI®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Timely-coordinated Therapy of Patients With Metastatic Cancer by Radiotherapy Together With Immune Checkpoint Inhibition
Status: COMPLETED
Conditions: Metastatic Cancer
Interventions: DRUG: Nivolumab|DRUG: Pembrolizumab|RADIATION: Radiotherapy|DRUG: Ipilimumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Evaluation of Ambu AuraGain Laryngeal Mask and Proseal Laryngeal Mask Airway
Status: COMPLETED
Conditions: Laryngeal Masks
Interventions: DEVICE: ProSeal Laryngeal Mask Airway|DEVICE: AmbuAuraGain Laryngeal Mask Airway
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Escitalopram Treatment In Acute Stroke
Status: WITHDRAWN
Conditions: Stroke
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Lipoic Acid on Glycaemic Control in Type 2 Diabetes
Status: WITHDRAWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Aged
Interventions: OTHER: Multidomain intervention program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Between Effect of Conventional, Intensive and Light Emitting Diodes (LED) Phototherapy on Oxidative Stress Among Neonates With Unconjugated Hyperbilirubinemia
Status: UNKNOWN
Conditions: Oxidative Stress|Neonatal Hyperbilirubinemia|Phototherapy Complication
Interventions: PROCEDURE: phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)
Status: RECRUITING
Conditions: ALK Gene Rearrangement|ALK Gene Translocation|ALK Positive|Stage IB Non-Small Cell Lung Carcinoma AJCC v7|Stage II Non-Small Cell Lung Cancer AJCC v7|Stage IIA Non-Small Cell Lung Carcinoma AJCC v7|Stage IIB Non-Small Cell Lung Carcinoma AJCC v7|Stage IIIA Non-Small Cell Lung Cancer AJCC v7
Interventions: OTHER: Clinical Observation|DRUG: Crizotinib|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Morphological and Functional Effects of a Foot Strengthening Protocol
Status: COMPLETED
Conditions: Foot Strength Deficit
Interventions: PROCEDURE: La Tour Hospital Foot Strengthening Protocol|PROCEDURE: Standard Literature Foot Strengthening Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer
Status: COMPLETED
Conditions: Rectal Mucinous Adenocarcinoma|Rectal Signet Ring Cell Adenocarcinoma|Recurrent Rectal Carcinoma|Stage IIA Rectal Cancer AJCC v7|Stage IIB Rectal Cancer AJCC v7|Stage IIC Rectal Cancer AJCC v7|Stage IIIA Rectal Cancer AJCC v7|Stage IIIB Rectal Cancer AJCC v7|Stage IIIC Rectal Cancer AJCC v7|Stage IVA Rectal Cancer AJCC v7|Stage IVB Rectal Cancer AJCC v7
Interventions: RADIATION: Radiotherapy|DRUG: Fluorouracil|DRUG: Leucovorin Calcium|DRUG: Oxaliplatin|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL
Status: COMPLETED
Conditions: LGL Leukemia|CTCL
Interventions: DRUG: BNZ132-1-40
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Anticoagulation Therapy on the Prognosis of Patients With Left Ventricular Thrombosis
Status: NOT_YET_RECRUITING
Conditions: Embolism and Thrombosis|Anticoagulation
Interventions: PROCEDURE: Extended anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of an Old Versus a New Total Knee Replacement
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis Knee
Interventions: RADIATION: RSA radiostereometric analysis|BEHAVIORAL: Clinical comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate as Maintenance Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Previously Treated With Combination Chemotherapy
Status: COMPLETED
Conditions: Stage IIIB Lung Non-Small Cell Cancer AJCC v7|Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Placebo|OTHER: Quality-of-Life Assessment|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Non-small Cell Lung Cancer|HR+/HER2- Ductal and Lobular Breast Cancer|Triple Negative Breast Cancer|Colorectal Cancer
Interventions: DRUG: [68Ga]Ga-NNS309|DRUG: [177Lu]Lu-NNS309
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Tolerability of Prucalopride in Constipated Elderly Subjects Living in a Nursing Facility
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Prucalopride|OTHER: Placebo|DRUG: Prucalopride|DRUG: Prucalopride|DRUG: Prucalopride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study In Patients With Non-Small Cell Lung Cancer To Test If Erlotinib Plus SU011248 Is Better Than Erlotinib Alone
Status: COMPLETED
Conditions: Carcinoma, Non-Small Cell Lung
Interventions: DRUG: erlotinib|DRUG: sunitinib|DRUG: erlotinib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Safety and Immunogenicity of a Vaccine Against HCMV
Status: COMPLETED
Conditions: Cytomegalovirus Infection
Interventions: BIOLOGICAL: Low dose HB-101|BIOLOGICAL: Medium dose HB-101|BIOLOGICAL: High dose HB-101|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: NAtive Collagen Type II In Healthy VoluntEers With Joint Discomfort
Status: COMPLETED
Conditions: Joint Pain
Interventions: DIETARY_SUPPLEMENT: Native type II collagen|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Nurse Practitioner Hospice Program for Patients With Terminal Metastatic Cancer and Their Families or Caregivers
Status: COMPLETED
Conditions: Hematopoietic/Lymphoid Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: counseling intervention|OTHER: questionnaire administration|OTHER: survey administration|PROCEDURE: end-of-life treatment/management|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: OTHER
Clinical trial: NRX-101 for Bipolar Depression With Subacute Suicidal Ideation
Status: COMPLETED
Conditions: Bipolar Depression|Suicidal Ideation and Behavior
Interventions: DRUG: NRX-101|DRUG: Lurasidone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response
Status: COMPLETED
Conditions: Advanced Unresectable or Metastatic Solid Malignancy
Interventions: DRUG: Entrectinib|DRUG: Inavolisib|DRUG: Alectinib|DRUG: Ipatasertib|DRUG: Atezolizumab|DRUG: Trastuzumab Emtansine|DRUG: Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf|DRUG: Tucatinib|DRUG: Investigator's Choice of Chemotherapy|DRUG: Paclitaxel|DRUG: Tiragolumab|DRUG: Pralsetinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Haemorrhage Risk Reduction Using Endovascular Embolisation in Place of Vessel Ligation for Patients Undergoing Transoral Robotic Surgery (HELPR)
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: PROCEDURE: Endovascular embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Granisetron vs Granisetron and Dexamethasone on the Reduction of Postoperative Nausea and Vomiting
Status: UNKNOWN
Conditions: PONV
Interventions: DRUG: Granisetron 1 Mg/mL Intravenous Solution And Dexamethasone 4mg|DRUG: Granisetron 1 Mg/mL Intravenous Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recombinant Human Endostatin in Combination With XELOX Therapy in Patient With Advanced Colorectal Cancer.
Status: UNKNOWN
Conditions: Quality of Life
Interventions: DRUG: oxaliplatin + capecitabine (XELOX chemotherapy)|DRUG: rebombniant human endostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Triamcinolone Acetonide Injections in Primary Cutaneous Lymphoma Plaques With a Novel Needle-free Drug-delivery System.
Status: NOT_YET_RECRUITING
Conditions: Mycosis Fungoides of Skin (Diagnosis)|Cutaneous T-cell Lymphoma|Non Hodgkin Lymphoma|Lymphomatoid Papulosis|Lymphoma, Large-Cell, Anaplastic|Lymphoma, Follicular
Interventions: DEVICE: Med-Jet Injector|DRUG: Triamcinolone Acetonide|DRUG: Bexarotene 1% Top Gel|DRUG: Nitrogen Mustard|DEVICE: Conventional syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Hypertension Intervention Nurse Telemedicine Study (HINTS)
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Nurse Behavioral intervention with Home BP Telemonitoring|BEHAVIORAL: Nurse Medication Management with Home BP Telemonitoring|BEHAVIORAL: Nurse Combined intervention with Home BP Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Process Validation in Dermatology: Assessing Methods for UV Exposure (Artificial Source vs. Sunlight) and Efficacy Evaluation of Anti-Tanning Agents
Status: COMPLETED
Conditions: Skin Pigmentation
Interventions: OTHER: Test Sun Protection Cream|OTHER: Benchmark Sun Protection Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EFFECTIVENESS OF GRADED MOTOR IMAGERY TO PREVENT CRPS IN PATIENTS WITH DISTAL RADIUS FRACTURE AFTER SURGERY
Status: UNKNOWN
Conditions: Wrist Fracture|CRPS (Complex Regional Pain Syndromes)|Distal Radius Fracture|Surgery
Interventions: OTHER: GMI protocol|OTHER: Standard Rehabilitation Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed/Carboplatin Non-Small Cell Lung Cancer (NSCLC) Elderly Patients
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: pemetrexed|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Single-center Cohort Study "Preoperative Identification of Sentinel Lymph Nodes Using Contrast-enhanced CT Lymphography in Breast Cancer Patients"
Status: UNKNOWN
Conditions: Breast Neoplasms|Sentinel Lymph Node
Interventions: DIAGNOSTIC_TEST: Contrast-enhanced CT lymphography with the periareolar injection of iopamidol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Hand Ultrasonography: Clinical and Functional Correlation in Symptomatic Osteoarthritis (OA)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study Done by a Demonstrator and Two Professors in Public Health and Community Medicine Department in Faculty of Medicine in Assiut and New Valley University to Assess Knowledge, Attitude ,and Practice of Rural Population in a Remote Governorate ( New Valley ) Towards Hepatitis B and C Viruses
Status: NOT_YET_RECRUITING
Conditions: Hepatitis B|Hepatitis C
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers
Status: COMPLETED
Conditions: Headache
Interventions: BEHAVIORAL: ACT+ MTAU|BEHAVIORAL: Waitlist Control +MTAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Tumescence in Breast Reduction Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Postoperative Nausea and Vomiting
Interventions: DRUG: Tumescent solution with dilute lidocaine and epinephrine|DRUG: Tumescent Solution with dilute epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Arginase-1 Peptide Vaccine in Patients With Metastatic Solid Tumors
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer|Urothelial Carcinoma|Malignant Melanoma|Ovarian Cancer|Colorectal Cancer|Breast Cancer|Squamous Cell Carcinoma of the Head and Neck|Metastatic Cancer
Interventions: BIOLOGICAL: ARG1-18,19,20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain, Emotions, and Mind-Wandering
Status: RECRUITING
Conditions: Mood Disorders
Interventions: BEHAVIORAL: Mindfulness-Based Intervention (MBI)|BEHAVIORAL: Health and Wellness Intervention (HWI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: evAluation of Glycemic RangE During acutE Coronary syndroME in Nondiabetic paTients (AGREEMENT)
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DEVICE: Continuous Glucose Monitoring System (i Pro 2 - Medtronic)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Auto-immunity and Pulmonary Arterial Hypertension
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension|HIV Infection|Congenital Heart Defect|Systemic Sclerosis|Connective Tissue Disease
Interventions: PROCEDURE: skin biopsy|OTHER: Blood Sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Health Economic Evaluation Alongside the OPERAM Trial
Status: COMPLETED
Conditions: 3 or More Chronic Conditions for 6 Months or Longer|5 or More Regular Drugs
Interventions: OTHER: STRIP intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Integrated Early Palliative Care for Advanced Gastric Cancer Patients
Status: RECRUITING
Conditions: Advanced Gastric Cancer
Interventions: OTHER: Intergrate early palliatuve care + Conventional chemotherapy|OTHER: Conventional chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: TheEffect of pH on Misoprostol in Induction of Labor
Status: UNKNOWN
Conditions: Labor Pain
Interventions: DRUG: misoprostol in a neutral media|DRUG: misoprostol in an acidic media|DRUG: misoprostol in an alkaline media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Probiotic Supplementation Prevent Kidney Injury During Strenuous Physical Exercise?
Status: COMPLETED
Conditions: Heat Stress|Kidney Injury
Interventions: DIETARY_SUPPLEMENT: Probiotic, Lactobacillus|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Ginkgo Biloba Special Extract LI 1370 on Dual-tasking in Patients With MCI
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DRUG: Ginkgo biloba
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Curcumin on Iron Metabolism in Healthy Volunteer
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: curcuma longa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Synchronized vs. Continuous HFNC Using NAVA on WOB in Infants With BPD
Status: TERMINATED
Conditions: Bronchopulmonary Dysplasia
Interventions: OTHER: Synchronized HFNC at 6 liters per minute (LPM)|OTHER: Continuous HFNC at 6 liters per minute (LPM)|OTHER: Synchronized HFNC at 8 liters per minute (LPM)|OTHER: Continuous HFNC at 8 liters per minute (LPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parameters of Cerebral Perfusion
Status: COMPLETED
Conditions: Cerebral Perfusion|Cerebral Oxygenation|Cardiopulmonary Bypass
Interventions: OTHER: 50-100ug phenylephrine before CPB|OTHER: 50-100ug phenylephrine during CPB|OTHER: decreasing CPB flow|OTHER: Decreasing CPB flow AND 50-100ug phenylephrine|OTHER: Increasing CPB flow
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Multi-Wavelength and Coherence Confocal Reflectance Microscopy of Pigmented and Non-Pigmented Lesions on the Skin In-Vivo
Status: COMPLETED
Conditions: Basal Cell Carcinoma|Melanoma|Non-Malignant Skin Disorders|Squamous Cell Carcinoma
Interventions: DEVICE: Multiwavelength and coherence confocal reflectance microscopy (Vivascope 1500m multiwavelength)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Continuous Skin to Skin Care (Technique Kangaroo: TK) After Birth for Low Birth Weight (LBW) Infants and Their Mothers in Developing Countries
Status: COMPLETED
Conditions: Low Birth Weight
Interventions: BEHAVIORAL: TK as soon as possible within 24 hours after birth|OTHER: Conventional care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Anti-PD1 Antibody PDR001, in Combination With Dabrafenib and Trametinib in Advanced Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Spartalizumab|OTHER: Placebo|DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regulating Emotions and Behaviors After Brain Injury
Status: RECRUITING
Conditions: Acquired Brain Injury|Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic)|Brain Tumor (After Recovery)|Encephalitis|Cerebral Anoxia|Meningitis
Interventions: BEHAVIORAL: Dialectical Behavior Therapy and Radically Open dialectical behavior therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)
Status: RECRUITING
Conditions: Out-Of-Hospital Cardiac Arrest|Pneumonia
Interventions: DRUG: Standard of care without prophylaxis|DRUG: Antibiotic prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Malignant Mixed Mesodermal Tumor (MMMT) - Early Stage With Postoperative XRT/Chemotherapy
Status: TERMINATED
Conditions: Uterine Neoplasms
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication
Status: RECRUITING
Conditions: Claudication, Intermittent|Peripheral Artery Disease|Peripheral Vascular Diseases
Interventions: DRUG: Tetrahydrobiopterin 10 mg/kg|DRUG: Tetrahydrobiopterin 20 mg/kg|DRUG: L-Ascorbate|DRUG: L-Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sympathetic Renal Denervation Versus Increment of Pharmacological Treatment in Resistant Arterial Hypertension.
Status: COMPLETED
Conditions: Resistant Arterial Hypertension
Interventions: PROCEDURE: Sympathetic Renal Denervation|DRUG: Treatment with aldactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A/H5N1 Dose Ranging Study With Adjuvant Patch
Status: COMPLETED
Conditions: Pandemic Influenza
Interventions: BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: A/H5N1|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Effectiveness of Irosustat When Added to an AI in ER+ve Locally Advanced or Metastatic Breast Cancer.
Status: COMPLETED
Conditions: Locally Advanced Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Irosustat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topical Antibacterial Agents for Prevention of COVID-19
Status: COMPLETED
Conditions: COVID-19|SARS-CoV2 Infection
Interventions: DRUG: Neosporin|OTHER: Vaseline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioural Therapy for Menopausal Symptoms
Status: COMPLETED
Conditions: Menopausal Depression
Interventions: OTHER: CBT for Menopausal Symptoms (CBT-Meno)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotics in Non-alcoholic Fatty Liver Disease and Steatohepatitis
Status: TERMINATED
Conditions: Fatty Liver Disease|Fibrosis, Liver|Cirrhosis, Liver|Steatohepatitis, Nonalcoholic
Interventions: DRUG: Align Probiotic Supplement Capsule|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gam-COVID-Vac in Adolescents
Status: UNKNOWN
Conditions: Covid19|Vaccine Preventable Disease
Interventions: BIOLOGICAL: Gam-COVID-vac M|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Oral Ondansetron Versus Transdermal Granisetron (Sancuso) for Women With Cervical, Endometrial or Vaginal Cancer Receiving Pelvic Chemoradiation
Status: COMPLETED
Conditions: Cancer of the Cervix
Interventions: DRUG: Granisetron|DRUG: Ondansetron|BEHAVIORAL: Questionnaires|BEHAVIORAL: Study Drug Diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery
Status: COMPLETED
Conditions: Ischemia-reperfusion Injury
Interventions: PROCEDURE: Remote ischemic post-conditioning (RIP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial
Status: RECRUITING
Conditions: Knee Osteoarthritis|Morbid Obesity
Interventions: PROCEDURE: bariatric surgery followed by total knee replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase III Clinical Trial Evaluating the Efficacy and Safety of 5-aminolevulinic Acid (5-ALA）
Status: NOT_YET_RECRUITING
Conditions: 5-aminolevulinic Acid|Fluorescence-guided Resection
Interventions: DRUG: 5-aminolevulinic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Tolerability Ultra-high-caloric Food Supplements in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DIETARY_SUPPLEMENT: high-caloric fatty diet|DIETARY_SUPPLEMENT: ultra-high-caloric fatty diet|DIETARY_SUPPLEMENT: ultra-high-caloric carbohydrate-rich diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment With Hepatic Arterial Infusion of Oxaliplatin in Combination With Systemic FOLFIRI Chemotherapy and Bevacuzimab in Patients With Liver-only Colorectal Liver Metastases (CRLM): Conversion to Complete Resection in Patients With Initially Inoperable Liver-only CRLM.
Status: UNKNOWN
Conditions: Liver Metastasis Colon Cancer
Interventions: DRUG: oxaliplatin|DRUG: FOLFIRI Protocol|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride, Rituximab, Oxaliplatin, and Lenalidomide in Treating Patients With Relapsed or Refractory, Aggressive Non-Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: gemcitabine hydrochloride|DRUG: lenalidomide|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Topotecan, Ifosfamide and Carboplatin in Children and Young Adults With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: Topotecan|DRUG: Ifosfamide|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)
Status: RECRUITING
Conditions: Crohn Disease
Interventions: PROCEDURE: high ligation of ileocolic artery|PROCEDURE: mesenteric sparing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Trial Evaluating the Immunogenicity of HPV Vaccination in Girls on Immunosuppressive Therapy.
Status: COMPLETED
Conditions: Transplantation|Systemic Lupus Erythematosus|Systemic Immune Disease
Interventions: BIOLOGICAL: HPV prophylactic vaccine Gardasil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Advair® DISKUS® Versus Serevent® DISKUS® For Chronic Obstructive Pulmonary Disease Exacerbations
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Fluticasone Propionate/Salmeterol Combination Product|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant PD-1 Antibody Plus Chemotherapy in Resectable Stage IIIA-N2 Non-Small-Cell Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Pemetrexed or Nab-paclitaxel|DRUG: PD-1 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electron Beam Radiotherapy for the Treatment of Refractory Sclerodermatous Chronic Graft Versus Host Disease
Status: WITHDRAWN
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm|Refractory Sclerodermatous Graft Versus Host Disease
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|COMBINATION_PRODUCT: Electron Beam Therapy|PROCEDURE: High Frequency Ultrasound Imaging|OTHER: Questionnaire Administration|RADIATION: Radiation Therapy Treatment Planning and Simulation|PROCEDURE: Skin Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Upper Anterior Teeth Retraction Rate Assisted by Two Corticotomy Techniques
Status: COMPLETED
Conditions: Class II Division 1 Malocclusion
Interventions: PROCEDURE: Traditional corticotomy|PROCEDURE: Flapless corticotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Urinary Retention Following taTME VS laTME Total Mesorectal Excision for Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: PROCEDURE: transanal total mesorectal excision|PROCEDURE: Laparoscopic Total Mesorectal Excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-center Study：Comparison of ACAF and ACCF in the Treatment of Cervical OPLL
Status: UNKNOWN
Conditions: Ossification of Posterior Longitudinal Ligament
Interventions: PROCEDURE: ACAF surgery|PROCEDURE: ACCF surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD)
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Medium Supplemented with Cytochalasin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Neuroprotective Effects of Remote Ischemic Preconditioning (RIPC) During Infant Cardiac Surgery
Status: COMPLETED
Conditions: Heart Defects, Congenital
Interventions: PROCEDURE: Remote Ischemic Preconditioning|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Prewarming On Skin Temperature Changes
Status: UNKNOWN
Conditions: Spinal Anesthesia|Hypothermia Following Anesthesia|Prewarming|Core Temperature|Urological Cancer
Interventions: PROCEDURE: Patients in Group II will receive active prewarming with an air forced blanket (full body blanket) 30 minutes prior to the operation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: nContactSurgical Numeris-AF Tethered Coagulation System for Treatment of Persistent & LSP AF
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Numeris-AF Tethered Coagulation System with VisiTrax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find the Best Dose of BI 905711 in Combination With Chemotherapy and to Test Whether This Dose Helps People With Advanced Gastrointestinal Cancers
Status: COMPLETED
Conditions: Gastrointestinal Cancer, Metastatic
Interventions: DRUG: BI 905711|DRUG: FOLFIRI|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lifitegrast 5% for the Treatment of Dry Eye In Habitual Soft Contact Lens Wearers
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Lifitegrast 5% Ophthalmic Solution|OTHER: Lifitegrast Ophthalmic Solution Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between the Effect of Ultrasound Guided Median Nerve Block , Radial Nerve Block and Local Infiltration on Feasibility of Radial Artery Cannulation
Status: UNKNOWN
Conditions: Radial Artery Cannulation
Interventions: PROCEDURE: median nerve block|PROCEDURE: radial nerve block|PROCEDURE: local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Targeted eHealth Intervention to Reduce Fear of Recurrence Among Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Fear of Cancer
Interventions: OTHER: Diaphragmatic breathing and relaxation|OTHER: Cognitive restructuring|OTHER: Scheduled worry practice|OTHER: Telephone coaching|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating the Necessity of TOT Implantation in Women With Pelvic Organ Prolapse and Occult Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence|Pelvic Organ Prolapse
Interventions: PROCEDURE: Pelvic Organ Prolapse and Suburethral TOT implantation|PROCEDURE: Pelvic Organ Prolapse intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase II Study of Oral Panobinostat (LBH589) and Rituximab to Treat Diffuse Large B Cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: LBH589|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Control of Chronic Hypertension
Status: TERMINATED
Conditions: Preeclampsia With Severe Features|Chronic Hypertension in Obstetric Context
Interventions: DRUG: Experimental dosing of labetalol|OTHER: Standard dosing of labetalol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance Study of the ARGOS-IO (Intraocular) System in Patients With Primary Open Angle Glaucoma (POAG)
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma (POAG)
Interventions: DEVICE: ARGOS-IO system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dynamic ROM Via Gait Analysis and 3D Fluoroscopy in THA With Different Head Diameters
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: DEVICE: THA Corail PinnacleCoC28|DEVICE: THA Corail DeltaMotion36|DEVICE: THA Corail DeltaMotion40
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Monoclonal Antibody Therapy in Treating Patients With Stage IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: B7-DC cross-linking antibody rHIgM12B7|OTHER: flow cytometry|OTHER: immunologic technique|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anterior Quadratus Lumborum Block Versus Erector Spina Plane Block in Percutaneous Nephrolithotomy Surgery
Status: COMPLETED
Conditions: Anesthesia|Analgesia|Patient Controlled Analgesia|Quadratus Lumborum Block|Erector Spina Plane Block
Interventions: PROCEDURE: Group QLB3|PROCEDURE: Group ESPB|OTHER: Group Control
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS
Status: COMPLETED
Conditions: Systemic Vasculitis
Interventions: DEVICE: Ultrasound|DEVICE: MRA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.
Status: COMPLETED
Conditions: Complicated Intra-abdominal Infection|Hosptial Acquired Pneumonia|Ventilator Associated Pneumonia
Interventions: DRUG: ATM-AVI|DRUG: MTZ|DRUG: MER|DRUG: COL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Checkpoint Inhibitor Associated Cardiovascular Adverse Events in Patients With Cancer
Status: RECRUITING
Conditions: Cardiovascular Diseases|Arterial Thrombosis|Myocardial Infarction|Stroke|Coronary Artery Disease|Atherosclerosis|Cancer
Interventions: DIAGNOSTIC_TEST: Coronary computed tomography angiography (CCTA) at baseline|DIAGNOSTIC_TEST: Coronary computed tomography angiography (CCTA) after 1 year
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ex Vivo Effect of Surfactant Protein D on Pulmonary Immune Cells Derived From Bronchoalveolar Lavage After Segmental Allergen Challenge in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: PROCEDURE: Bronchoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
Status: RECRUITING
Conditions: Gastric Cancer|Gastroesophageal Junction Cancer
Interventions: DRUG: AZD0901|DRUG: AZD0901|DRUG: Ramucirumab+ paclitaxel|DRUG: Paclitaxel|DRUG: Docetaxel|DRUG: Irinotecan|DRUG: TAS-102|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT