pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Carboplatin and Bevacizumab for Progressive Breast Cancer Brain Metastases
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Breast Cancer|Progressive Breast Cancer
Interventions: DRUG: carboplatin|DRUG: bevacizumab|DRUG: herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endometrial Biopsy as Diagnostic Method for Endometriosis and Endometrioma
Status: UNKNOWN
Conditions: Women in the Reproductive Age Group|Undergoing Laparoscopy for Pelvic Pain and/or Infertility|Not Currently Receiving Hormonal Treatment for at Least 3 Months Prior to Laparoscopy.
Interventions: PROCEDURE: Endometrial biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Swift Outpatient Alternatives for Rapid Stabilization
Status: RECRUITING
Conditions: Suicidal Ideation|Suicide Attempt
Interventions: BEHAVIORAL: CAMS Single Session Consultation|BEHAVIORAL: Driver Focused Skills Training|BEHAVIORAL: Caregiver Skills Training|BEHAVIORAL: Lethal Means Safety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Application and Mechanism of Cord Blood Mononuclear Cells in the Treatment of Ischemic Bowel Disease
Status: UNKNOWN
Conditions: Ischemic Bowel Disease
Interventions: OTHER: Human Umbilical Cord blood mononuclear cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Bosentan in Type II Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Bosentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis|Hepatic Cell Carcinoma|Portal Hypertension
Interventions: DRUG: Injection of a gadolinium contrast agen|DRUG: Radiotracer Injection|DIAGNOSTIC_TEST: Imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility Testing a shareD dEciSIon Making Intervention for People With Kidney failuRE, Their Relatives, and the Health Professionals in Kidney Services: a Pilot Randomized Controlled Trial Study Protocol
Status: COMPLETED
Conditions: Kidney Failure|End of Life
Interventions: OTHER: Shared decision making intervention for patients with kidney failure when planning end-of-life care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Effectiveness of Mental Health Interventions Among Torture Survivors in Southern Iraq
Status: COMPLETED
Conditions: Depression|Anxiety|Post-Traumatic Stress Disorder
Interventions: OTHER: Cognitive Processing Therapy|OTHER: Components-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Quality and Quantity of Antibiotic Prescriptions for Bacterial Respiratory Tract Superinfection in Patients Hospitalized in COVID-19 Wards
Status: UNKNOWN
Conditions: SARS-CoV Infection|Antimicrobial Stewardship|Respiratory Tract Infections|Antibiotic Resistance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia
Status: COMPLETED
Conditions: Amblyopia
Interventions: DRUG: levodopa/carbidopa|DEVICE: patching|DRUG: levodopa/carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptive Approach to Neoadjuvant Therapy to Maximize Resection Rates for Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Pancreas Cancer
Interventions: DRUG: Folfirinox|DRUG: Gemcitabine|RADIATION: radiation therapy|PROCEDURE: Pancreatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AZD1656 in Transplantation With Diabetes tO PromoTe Immune TOleraNce
Status: COMPLETED
Conditions: Type 2 Diabetes|Diabetes Mellitus, Type 2|Renal Transplant|Kidney Transplant; Complications|End Stage Renal Disease
Interventions: DRUG: AZD1656|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oropharynx (OPX) Biomarker Trial
Status: RECRUITING
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Metastatic Oropharyngeal Squamous Cell Carcinoma|Oropharyngeal Squamous Cell Carcinoma|Recurrent Oropharyngeal Squamous Cell Carcinoma|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: OTHER: Non-Interventional Study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HKT-500 in Adult Patients With Shoulder Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: HKT-500 Ketoprofen Topical Patch|OTHER: Placebo Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Socio-educational Intervention on Sexual Health in Young University Students
Status: UNKNOWN
Conditions: Sexual Health
Interventions: BEHAVIORAL: The Right to your Sexual Health|BEHAVIORAL: Friendly sexual health services and reproductive for adolescents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section
Status: TERMINATED
Conditions: Pain, Postoperative|Cesarean Section
Interventions: DRUG: Ropivacaine|PROCEDURE: TAP block|BIOLOGICAL: QL block|PROCEDURE: ESP block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Erlotinib in Patients With Non-Metastatic Prostate Cancer With a Rising Prostate Specific Antigen (PSA) on Hormone Therapy
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Erlotinib (Tarceva)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Respiratory Syncytial Virus - RSV Protocol
Status: COMPLETED
Conditions: Bone Marrow Transplant Infection|Infection in Marrow Transplant Recipients|Respiratory Syncytial Virus Infections|Respiratory Syncytial Virus Pneumonia|Cancer|Acute Leukemia
Interventions: DRUG: Ribavirin|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PPI Versus Histamine Antagnists as Adjuvant to Chemotherapy
Status: RECRUITING
Conditions: Lymphoma
Interventions: DRUG: CHOP|DRUG: CHOP Plus Lanzoprazole|DRUG: CHOP Plus Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 64Cu-DOTA Pembrolizumab for Imaging Metastatic Solid Tumors in Patients Receiving Stereotactic Body Radiation
Status: WITHDRAWN
Conditions: Metastatic Malignant Solid Neoplasm
Interventions: DRUG: Copper Cu 64-DOTA-pembrolizumab|PROCEDURE: Positron Emission Tomography|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Competency-based Training in Problem Management Plus: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Standard Problem Management Plus training (training as usual)|BEHAVIORAL: Equip-based Problem Management Plus training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Characterizing Recurrent Thromboembolism, Major Bleeding and All-Cause Death in Patients With Cancer-Associated Thromboembolism Treated With Rivaroxaban
Status: COMPLETED
Conditions: Venous Thromboembolism
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exercise Intervention in Patients With Heart Failure With Preserved and Reduced Ejection Fraction
Status: ENROLLING_BY_INVITATION
Conditions: Heart Failure New York Heart Association (NYHA) Class II|Heart Failure New York Heart Association (NYHA) Class III
Interventions: OTHER: Supervised Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY4170156 in Participants With Selected Advanced Solid Tumors
Status: RECRUITING
Conditions: Ovarian Neoplasms|Endometrial Neoplasms|Uterine Cervical Neoplasms|Carcinoma, Non-Small-Cell Lung|Triple Negative Breast Neoplasms|Pancreatic Neoplasm|Colorectal Neoplasms
Interventions: DRUG: LY4170156
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Sitting Versus Lateral Position During Spinal Anesthesia on the Severity of Hypotension:
Status: ACTIVE_NOT_RECRUITING
Conditions: Severty of Hpotention
Interventions: PROCEDURE: lateral position procedure|PROCEDURE: sitting position porocedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma
Status: COMPLETED
Conditions: Chemotherapeutic Agent Toxicity|Cognitive/Functional Effects|Lymphoma|Neurotoxicity|Radiation Toxicity
Interventions: BIOLOGICAL: Rituximab|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Procarbazine|DRUG: Vincristine|RADIATION: low-dose whole-brain radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Fosinopril Sodium/ Hydrochlorothiazide 20/ 12.5 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fosinopril sodium and hydrochlorothiazide 20-12.5 mg tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Focused Ultrasound and Pembrolizumab in Metastatic Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Pembrolizumab|DEVICE: High-intensity focused ultrasound (HIFU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Refractory Breast Carcinoma|Triple-Negative Breast Carcinoma
Interventions: DRUG: Alpelisib|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Abraxane™ Given Weekly as a Single Agent in First-line Treatment of Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Paclitaxel Albumin Nanoparticle for Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Status: TERMINATED
Conditions: in Vitro Fertilization|Ovulation Induction
Interventions: DRUG: Mild stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites
Status: RECRUITING
Conditions: Pleural Effusion, Malignant
Interventions: DRUG: IFN-γ and CIK cells, Tcm cells or CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Feasibility of the OpiVenture Program for Clients Undergoing Opioid Agonist Therapy
Status: NOT_YET_RECRUITING
Conditions: Opioid Use Disorder|Polysubstance Addiction|Substance Use
Interventions: BEHAVIORAL: OpiVenture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Different Mattress Types on Sleep Quality in Adult Individuals With Idiopathic Scoliosis
Status: COMPLETED
Conditions: Idiopathic Scoliosis|Sleep
Interventions: DEVICE: Mattress 1|DEVICE: Mattress 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine
Status: RECRUITING
Conditions: Migraine
Interventions: DRUG: Eptinezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intensive Neurowave Emotional Stimulation (INES)
Status: RECRUITING
Conditions: Disorders of Consciousness
Interventions: DEVICE: Intensive Neurowave Emotional Stimulation (INES)|OTHER: Intensive Sensorial Emotional Stimulation (ISES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: S1014 Abiraterone Acetate in Treating Patients With Prostate Cancer Who Have Undergone Initial Hormone Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: abiraterone acetate|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Clemastine and Aerobic Exercise to Treat Cognitive Dysfunction in Schizophrenia by Targeting Myelin Plasticity
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia
Interventions: DRUG: clemastine (8 mg/day)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sargramostim, Vaccine Therapy, or Sargramostim and Vaccine Therapy in Preventing Disease Recurrence in Patients With Melanoma That Has Been Removed By Surgery
Status: COMPLETED
Conditions: Iris Melanoma|Medium/Large Size Posterior Uveal Melanoma|Mucosal Melanoma|Ocular Melanoma With Extraocular Extension|Recurrent Melanoma|Recurrent Uveal Melanoma|Small Size Posterior Uveal Melanoma|Stage IIA Cutaneous Melanoma AJCC v6 and v7|Stage IIA Uveal Melanoma AJCC v7|Stage IIB Cutaneous Melanoma AJCC v6 and v7|Stage IIB Uveal Melanoma AJCC v7|Stage IIC Cutaneous Melanoma AJCC v6 and v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIA Uveal Melanoma AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIB Uveal Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IIIC Uveal Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Uveal Melanoma AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Placebo|OTHER: Placebo|BIOLOGICAL: Sargramostim|BIOLOGICAL: Tyrosinase Peptide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Renal Vasculature and Function With Ferumoxytol-enhanced Magnetic Resonance Imaging
Status: RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DRUG: domestic polysaccharide superparamagnetic iron oxide nanoparticle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Comparing Two Alternatives of Antiretroviral Therapy as Post-exposure Prophylaxis to HIV-1:FOVIR+EMTRICITABINA + LOPINAVIR/RITONAVIR VS TENOFOVIR+EMTRICITABINA + MARAVIROC (MARAVI-PEP)
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Tenofovir, emtricitabine, maraviroc|DRUG: Tenofovir, emtricitabine, lopinavir/r
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Randomized, No-treatment Controlled, Evaluator-blinded Clinical Trial to Evaluate the Efficacy and Safety of Polycaprolactone Microspherical Injectable to Improve Forehead Contour
Status: NOT_YET_RECRUITING
Conditions: Forehead Contouring
Interventions: DEVICE: Polycaprolactone (PCL) Based Facial Injectable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multifactorial Fall Prevention Program
Status: RECRUITING
Conditions: Frail Elderly Syndrome
Interventions: BEHAVIORAL: Physical exercise program (VIVIFRAIL) supervised by a physiotherapist|BEHAVIORAL: Adequacy of the environment|BEHAVIORAL: Polypharmacy review|BEHAVIORAL: Health education related to falls prevention (4 sessions)|BEHAVIORAL: General Assement|BEHAVIORAL: Evaluation of patients by an expert group|BEHAVIORAL: Information brochures on the importance of physical exercise|BEHAVIORAL: Physical exercise program (VIVIFRAIL) supervised by a primary care doctor or primary care nurse|BEHAVIORAL: Regular assessment and follow-up by primary care doctor and primary care nurse|BEHAVIORAL: Health education related to falls prevention (1 session)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Accuracy of Spectrophotometry in Hypomineralized Lesions Treated With CPP-ACPF Dental Mousse: Clinical Study
Status: NOT_YET_RECRUITING
Conditions: Molar Incisor Hypomineralization
Interventions: PROCEDURE: Application of dental mousse based on CPP-ACPF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Prophylactic TAF for HBsAg-positive Patients Receiving bDMARDs
Status: NOT_YET_RECRUITING
Conditions: HBV|Inflammatory Arthritis
Interventions: DRUG: Tenofovir alafenamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Comparison of Desflurane and Sevoflurane on Postoperative Recovery and Hepatic Function of Biliary Atresia Patients During Kasai Operation
Status: COMPLETED
Conditions: Kasai Operation|Biliary Atresia
Interventions: DRUG: desflurane anesthetics|DRUG: sevoflurane anesthetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KAT-101 in Subjects With Hepatocellular Carcinoma (HCC)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma|Fibrolamellar Carcinoma
Interventions: DRUG: KAT-101|DRUG: KAT-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Myofunctional Therapy in Class II Patients
Status: UNKNOWN
Conditions: Efficacy|Myofunctional Therapy|Orthopedics
Interventions: OTHER: Myofuncional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued
Status: COMPLETED
Conditions: NSAID Associated Gastric Ulcers
Interventions: DRUG: Esomeprazole|DRUG: Ranitidine|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3971297 in Healthy Participants and Participants With Obesity and Hypertension
Status: RECRUITING
Conditions: Healthy|Obesity|Hypertension
Interventions: DRUG: LY3971297|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)
Status: COMPLETED
Conditions: Critically Ill|Pneumonia
Interventions: DRUG: Ceftolozane/Tazobactam - Multiple Doses|DRUG: Ceftolozane/Tazobactam - Single Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Air Leak Monitoring for Patients Undergoing Lung Resection
Status: COMPLETED
Conditions: Pneumothorax|Atelectasis
Interventions: DEVICE: Digital pleural drainage system|DEVICE: Dry suction pleura drainage device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Sleep Quality of Hospitalized Patients Treated With EEG-guided Protection Procedures: Application in Intensive Care Unit
Status: RECRUITING
Conditions: Sleep Quality|Critically Ill Patient|Intensive Care Unit
Interventions: DEVICE: EEG-guided sleep protection|OTHER: Control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Open-Label Study of the Safety, Tolerance, and Pharmacokinetic Interactions of Combination Didanosine and Ribavirin in HIV-Positive Individuals
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ribavirin|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Testing to Screen for Unknown Coronary Artery Disease in Diabetic Patients: Does it Contribute to a Risk Reduction in Very High Risk Patients?
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes Mellitus
Interventions: PROCEDURE: exercise testing - coronary angiography - revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas
Status: COMPLETED
Conditions: Sarcoma|Soft Tissue Sarcoma|Locally Advanced Sarcoma|Unresectable Sarcoma|Metastatic Sarcoma
Interventions: DRUG: Bevacizumab, Gemcitabine, Docetaxel and Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tolerability of Rivastigmine Before and After Switching From Oral Formulation to Transdermal Patch in Alzheimer's Dementia
Status: COMPLETED
Conditions: Alzheimer's Dementia
Interventions: DRUG: ENA713
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Colchicine Inhibit Abdominal Aortic Aneurysm Growth Trial
Status: NOT_YET_RECRUITING
Conditions: Colchicine|Abdominal Aortic Aneurysm|Progression
Interventions: DRUG: colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mood and Smoking: A Comparison of Smoking Cessation Treatments
Status: COMPLETED
Conditions: Smoking Cessation|Mood Tolerance|Mood Management|Nicotine Replacement Therapy
Interventions: BEHAVIORAL: Mood Tolearance|BEHAVIORAL: Mood Management|DRUG: Nicotine Replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose:
Clinical trial: Nutraceuticals Versus Usual Care in the Prevention or Reduction of CIPN in Patients Treated With Docetaxel as Neoadjuvant/Adjuvant Breast Cancer Therapy
Status: TERMINATED
Conditions: Peripheral Neuropathy in Breast Cancer Patient
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Vitamin B6|DIETARY_SUPPLEMENT: Vitamin B12|DIETARY_SUPPLEMENT: Omega-3 Fatty Acids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Acuity After the Combined Binocular Implantation of +2.75 Diopters and +3.25 Diopters Tecnis Multifocal Intraocular Lenses.
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Binocular cataract surgery with phacoemulsification and implantation of multifocal intraocular lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Eslicarbazepine Acetate as Adjunctive Therapy for Refractory Partial Epilepsy
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: eslicarbazepine acetate|DRUG: placebo (Part I)|DRUG: ESL - Open-label Extension (Part II)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-life Clinical FEIBA Samples Measured Using the Version A of the HemA EnzySystem
Status: COMPLETED
Conditions: Hemophilia A With Inhibitor|Hemophilia A
Interventions: DIAGNOSTIC_TEST: Thrombin generation assay (EnzySystem HemA version A - whole blood)|DIAGNOSTIC_TEST: Thrombin generation assay (Ceveron s100 (Technoclone) - fresh plasma)|DIAGNOSTIC_TEST: Additional coagulation tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Calcium Supplementation in Postmenopausal Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: PTH/Calcium|DRUG: PTH/placebo|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety of Double-dose Dolutegravir When Used With Rifapentine for HIV-associated Tuberculosis
Status: RECRUITING
Conditions: HIV-associated Tuberculosis
Interventions: DRUG: Dolutegravir (DTG) 50 mg orally BID (~12 hours apart) plus TDF/3TC|DRUG: DTG 50 mg orally QD plus TDF/3TC|DRUG: 2HPZM|DRUG: 2HPM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapamycin Plus Methylprednisolone Versus Methylprednisolone Alone in Active, Moderate-to-severe Graves' Orbitopathy.
Status: UNKNOWN
Conditions: Graves Ophthalmopathy
Interventions: DRUG: Rapamycin|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Novel Antisense Oligonucleotide Eye Drops for Treating Antibiotic-Resistant Bacterial Keratitis
Status: RECRUITING
Conditions: Bacterial Keratitis|Antibiotic-resistant Bacteria|Infections, Bacterial|Corneal Diseases|Eye Diseases|Vision Disorders|Sensation Disorders|Blindness|Antisense Peptide Nucleic Acid|Antibacterial Therapy
Interventions: DRUG: ASO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Open Label, Extension Study Assessing the Efficacy and Safety of Additional Intravitreal Injections of RBM-007 in Subjects With Wet Age-related Macular Degeneration
Status: COMPLETED
Conditions: Exudative Age-related Macular Degeneration
Interventions: DRUG: RBM-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Mindfulness Based Stress Reduction on Patients With Traumatic Brain Injury
Status: COMPLETED
Conditions: Traumatic Brain Injury|Brain Injury|Stress
Interventions: OTHER: Mindfulness Based Stress Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab and Radiotherapy in Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Pembrolizumab|RADIATION: Stereotactic Body Radiotherapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immersive Virtual Reality for Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathy|Phantom Limb Pain|Complex Regional Pain Syndromes|Neuropathic Pain
Interventions: OTHER: Immersive Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Subthreshold Stimulation on Chronic Low Neck Pain Myofascial Trigger Points
Status: NOT_YET_RECRUITING
Conditions: Chronic Neck Pain
Interventions: DEVICE: Subthreshold Electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]
Status: COMPLETED
Conditions: Retinitis Pigmentosa|Retinitis|Retinal Diseases|Eye Diseases|Eye Diseases, Hereditary|Retinal Dystrophies|Retinal Degeneration
Interventions: BIOLOGICAL: Gene Therapy Product-MCO-010|PROCEDURE: Sham Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Intra-articular DLX105 Applied to Patients With Severely Painful Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: DLX105, a single-chain (scFv) antibody fragment against TNF-alpha|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pravastatin Intervention to Delay Hepatocellular Carcinoma Recurrence
Status: TERMINATED
Conditions: Hepatocellular Carcinoma|Liver Cirrhoses
Interventions: DRUG: Pravastatin Pill|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa|Osteoporosis
Interventions: DRUG: Placebo|DRUG: Teriparatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation Following Lumbar Disc Surgery
Status: COMPLETED
Conditions: Lumbar Disc Herniation|Radiculopathy
Interventions: OTHER: Rehabilitation following lumbar disc surgery (discectomy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adding a Second Drug for Febrile Children Treated With Acetaminophen
Status: UNKNOWN
Conditions: Fever
Interventions: DRUG: Ibuprofen, acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide Maintenance Versus Placebo in Responding Elderly Patients With DLBCL and Treated With R-CHOP
Status: COMPLETED
Conditions: Lymphoma|Diffuse Large B-cell Lymphoma
Interventions: DRUG: Lenalidomide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First-Line Treatment for Locally Advanced or Metastatic Mesenchymal Epithelial Transition Factor (MET) - Positive Gastric, Lower Esophageal, or Gastroesophageal Junction (GEJ) Adenocarcinoma
Status: TERMINATED
Conditions: Gastric Cancer
Interventions: DRUG: Rilotumumab|OTHER: Placebo|DRUG: Epirubicin|DRUG: Cisplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001)
Status: COMPLETED
Conditions: Prevention of CMV Infection or Disease
Interventions: DRUG: Letermovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Human Immune Response to the JYNNEOS Vaccine
Status: RECRUITING
Conditions: Vaccinia|Virus Diseases
Interventions: BIOLOGICAL: JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) suspension for subcutaneous injection|PROCEDURE: Phlebotomy|PROCEDURE: Research bronchoscopy|PROCEDURE: Skin punch biopsy|PROCEDURE: Bone marrow aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of DT56a (Femarelle) on the Coagulation System in the Treatment of Postmenopausal Women
Status: COMPLETED
Conditions: Menopause|Thrombophilia
Interventions: DIETARY_SUPPLEMENT: DT56a (Femarelle) [Se-cure pharmaceuticals, Dalton, Israel]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Femoral Blockade and Low-dose Spinal Anesthesia in Outpatient Knee Arthroscopy
Status: COMPLETED
Conditions: Meniscus Lesion
Interventions: DRUG: Femoral blockade|DRUG: Intrathecal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Valgus Unloader Brace on Medial Femoral Cartilage
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Össür Unloading Knee Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Simtuzumab in HIV and/or Hepatitis C- Infected Adults With Liver Fibrosis
Status: COMPLETED
Conditions: Liver Fibrosis|Hepatitis C|HIV|HIV/HCV Co-infection
Interventions: BIOLOGICAL: Simtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial
Status: RECRUITING
Conditions: Cesarean Section; Dehiscence|Uterine Bleeding|Uterus; Scar|Uterus Abnormal|Cesarean Section Complications
Interventions: PROCEDURE: Hysterotomy closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fraction
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure With Normal Ejection Fraction
Interventions: OTHER: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Using a VLS Using GlideRite Stylet Versus TCI Articulating Introducer in Predictive Difficult Intubation
Status: RECRUITING
Conditions: Predicted Difficult Airway
Interventions: DEVICE: video-laryngoscope and GlideRite Rigid Stylet|DEVICE: video-laryngoscope and TCI Articulating Introducer Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Olopatadine HCl Ophthalmic Solutions Compared to Vehicle Using the Conjunctival Allergen Challenge (CAC) Model of Acute Allergic Conjunctivitis in Japanese Subjects
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: Olopatadine Hydrochloride Ophthalmic Solution, 0.2%|DRUG: Olopatadine Hydrochloride Ophthalmic Solution, 0.1%|DRUG: Olopatadine 0.2% Vehicle|DRUG: Olopatadine 0.1% Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quantitating the Impact of Plerixafor
Status: UNKNOWN
Conditions: Transplants and Implants
Interventions: DRUG: plerixafor|DRUG: Bortezomib|OTHER: plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Elucidation of Acid-Induced Pulmonary Inflammation
Status: TERMINATED
Conditions: Gastroesophageal Reflux|Asthma
Interventions: DRUG: lansoprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Shenqi Sherong Pill in Participants With Cervical Spondylotic Myelopathy
Status: RECRUITING
Conditions: Cervical Spondylotic Myelopathy
Interventions: DRUG: Shenqi Sherong Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Open-label Study to Evaluate Pharmacokinetics of TAK-272 in Participants With Renal or Hepatic Impairment
Status: COMPLETED
Conditions: Renal Impairment|Hepatic Impairment
Interventions: DRUG: TAK-272
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of DPP4 Inhibitor on Cisplatin Induced Acute Kidney Injury
Status: UNKNOWN
Conditions: Cancer|Cisplatin Adverse Reaction
Interventions: DRUG: Gemigliptin|DRUG: Placebo|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia
Status: COMPLETED
Conditions: Postoperative Residual Curarization|Residual Neuromuscular Block
Interventions: DRUG: Cisatracurium|DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Medico Economic Evaluation of Dermal Substitute Integra® for Coverage of Inferior Limb Traumatic Skin Loss
Status: COMPLETED
Conditions: Leg Injuries|Ankle Injuries|Foot Injuries
Interventions: DEVICE: INTEGRA®|PROCEDURE: Flap technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Rituximab Therapy for Systemic Lupus Erythematosus (SLE) and Vasculitis
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus|ANCA Associated Vasculitis
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Combinations of Several Antiviral Drugs in Infants and Young Children With HIV Infection
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Abacavir sulfate|DRUG: Nelfinavir mesylate|DRUG: Nevirapine|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System
Status: NOT_YET_RECRUITING
Conditions: Anxiety|Depression|Burnout, Professional|Emotion Regulation
Interventions: BEHAVIORAL: Action In Mindfulness (AIM)+|BEHAVIORAL: Resource+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: RCT of Internet-Delivered CBT Treatments for Pathological Gambling: Comparing the Effects of Added Involvement From CSOs
Status: COMPLETED
Conditions: Gambling
Interventions: BEHAVIORAL: Behavioral Couples Therapy (BCT)|BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Oat Compounds on Postprandial Glucose Response
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: OTHER: High beta glucans|OTHER: Low beta glucans|OTHER: Low beta glucans + low polar lipids|OTHER: Polar lipids|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Brain Stimulation and Strategic Memory Training
Status: NOT_YET_RECRUITING
Conditions: Cognitive Decline|Healthy Aging
Interventions: OTHER: Non-invasive brain stimulation|OTHER: Sham non-invasive brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of TAK-503 in Children and Teenagers With Attention Deficit Hyperactivity Disorder (ADHD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Guanfacine hydrochloride (TAK-503)|DRUG: Atomoxetine hydrochloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BI 2536 BS in Patients With Advanced Solid Tumours and Repeated Administration in Patients With Clinical Benefit
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: BI 2536 BS, intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography.
Status: RECRUITING
Conditions: Cholangitis|Pancreatic Cancer|Choledocholithiasis|Choledochal Cyst
Interventions: DRUG: Ketamine|DRUG: Midazolam|DRUG: Pethidin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Proton Radiation Therapy With Cisplatin and Etoposide Followed by Surgery in Stage III Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: RADIATION: Proton Beam Radiation|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided Versus Landmark-guided Percutaneous Dilational Tracheostomy in Pediatric Patients
Status: NOT_YET_RECRUITING
Conditions: Tracheostomy Complication|Tracheostomy Hemorrhage|Airway Trauma|Percutaneous Tracheostomy
Interventions: DEVICE: Ultrasound-guided percutaneous dilatational tracheosyomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Envafolimab Monotherapy or Envafolimab + CAPEOX as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer
Status: RECRUITING
Conditions: Colon Cancer|Neoadjuvant Therapy|Immunotherapy
Interventions: DRUG: Envafolimab|DRUG: CAPEOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Multiple Doses of Fluconazole, a CYP3A4 and CYP2C9 Inhibitor, on the Pharmacokinetics of CTP-543 in Healthy Subjects
Status: COMPLETED
Conditions: Health Volunteers
Interventions: DRUG: CTP-543|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Role of Vitamin D in Menopause: Relationship to Menopausal Symptoms in Body Composition
Status: COMPLETED
Conditions: Hot Flushes|Menopause, Premature|Obesity|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH