pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dose De-escalation in Prostate Radiotherapy Using the MRL
Status: RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: RADIATION: De-escalated radiotherapy to be delivered on the Elekta Unity Unity MR-linac
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis
Status: RECRUITING
Conditions: Cystic Fibrosis
Interventions: DRUG: Resveratrol|DRUG: NR|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Patients After Allo-HSCT With Decitabine and NAC
Status: NOT_YET_RECRUITING
Conditions: Engraft Failure|Relapse|GVHD
Interventions: DRUG: decitabine|DRUG: Acetylcysteine|DRUG: Semustine|DRUG: Cytarabine|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Cyclosporin A|DRUG: Anti-thymocyte globulin|DRUG: Mycophenolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions
Status: COMPLETED
Conditions: Localized Resectable Neuroblastoma|Localized Unresectable Neuroblastoma|Recurrent Neuroblastoma|Regional Neuroblastoma|Stage 4 Neuroblastoma
Interventions: OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prolonged Clinical Follow-up of OPTIMA-5
Status: COMPLETED
Conditions: ST-segment Elevation Myocardial Infarction (STEMI)
Interventions: DRUG: Recombinant Staphylokinase|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Epoetin Alfa 40,000 IU (International Units) Every Week or 80,000 IU Every Week Compared to Placebo in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes at Risk for Transfusion
Status: TERMINATED
Conditions: Myelodysplastic Syndromes|Anemia
Interventions: DRUG: Placebo|DRUG: Epoetin alfa|DRUG: Placebo|DRUG: Epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IV NSAI Versus Nebulized Morphine Analgesia for First-line Renal Colic
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: IV NSAI|DRUG: NM|DRUG: IV Serum Saline|DRUG: Nebulised Serum Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Booster Immunization of ZF2001 After Inoculation With Two Doses of CoronaVac
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant novel coronavirus vaccine (CHO cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of a Training Intervention on Mental Health of Parents for Intellectually Disabled Children in Malawi
Status: COMPLETED
Conditions: Depression|Learning Disability
Interventions: BEHAVIORAL: Psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Factorial Study of Metoprolol Succinate TOPROL-XL (324A)
Status: COMPLETED
Conditions: High Blood Pressure (Hypertension).
Interventions: DRUG: Metoprolol Succinate|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Binimetinib Encorafenib Pembrolizumab +/- Stereotactic Radiosurgery in BRAFV600 Melanoma With Brain Metastasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Melanoma|BRAF V600 Mutation|Brain Metastases
Interventions: RADIATION: Stereotaxic radiosurgery (SRS)|DRUG: Binimetinib Oral Tablet|DRUG: Encorafenib Oral Capsule|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of A PVP-I Fluoride Varnish
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Test varnish|DRUG: Standard varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Irinotecan Liposomes in First-line Treatment of Metastatic Colorectal Cancer
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Irinotecan Liposome|DRUG: 5-FU|DRUG: LV|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Full Metall Jacket Multilevel Segment
Status: RECRUITING
Conditions: Superficial Femoral Artery Stenosis|Iliac Artery Occlusion
Interventions: PROCEDURE: Hybrid revascularization|PROCEDURE: Full metall Jacket
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural Killer (NK) Cell Transplantation for AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cyclophosphamide, Fludarabine, Clofarabine, Etoposide, Interleukin-2|PROCEDURE: Natural Killer Cell Infusion|DEVICE: CliniMACS System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Nodal Marginal Zone B-cell Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Adult Diffuse Mixed Cell Lymphoma|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Grade III Lymphomatoid Granulomatosis|Recurrent Adult Immunoblastic Large Cell Lymphoma|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Adult T-cell Leukemia/Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Refractory Multiple Myeloma|Small Intestine Lymphoma|Splenic Marginal Zone Lymphoma|Stage II Multiple Myeloma|Stage III Multiple Myeloma|Testicular Lymphoma|Waldenström Macroglobulinemia
Interventions: DRUG: chemotherapy|RADIATION: total-body irradiation|PROCEDURE: peripheral blood stem cell transplantation|DRUG: cyclosporine|DRUG: mycophenolate mofetil|PROCEDURE: allogeneic hematopoietic stem cell transplantation|BIOLOGICAL: therapeutic allogeneic lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Hormone-Sensitive Prostate Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Enzalutamide|DRUG: Androgen Deprivation Therapy (ADT)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months?
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Vitamin D|DIETARY_SUPPLEMENT: Vitamin D|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Talampanel on Patients With Advanced Parkinson's Disease
Status: COMPLETED
Conditions: Dyskinesias|Parkinson Disease|Movement Disorders
Interventions: DRUG: talampanel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Respiratory Drugs in Combination and Separately From a Novel Inhaler Device in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone foroate/ vilanterol|DRUG: Fluticasone foroate|DRUG: Vilanterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: |Primary Purpose: TREATMENT
Clinical trial: Dose Escalation, Open-Label Clinical Trial to Evaluate Safety, Tolerability and Immunogenicity of a Nipah Virus (NiV) mRNA Vaccine, mRNA-1215, in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Nipah Virus Infection
Interventions: BIOLOGICAL: mRNA -1215
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Buprenorphine Pharmacometric Open Label Research Study of Drug Exposure
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome|Neonatal Opiate Withdrawal Syndrome
Interventions: DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy or Acupuncture for Lateral Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: DEVICE: Acupuncture|OTHER: Physiotherapy and eccentric exercise|OTHER: Watchful waiting and eccentric exercise|OTHER: eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome Measures Study on an Adult Myoelectric Elbow-Wrist-Hand Orthosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Brachial Plexus Injury|Spinal Cord Injuries|Neurological Disease
Interventions: DEVICE: Myoelectric Elbow-Wrist-Hand Orthosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Improving Parenting Skills Adult ADHD (IPSA): A New Parent Training Program for Parents With ADHD
Status: ACTIVE_NOT_RECRUITING
Conditions: Parenting|Adult ADHD|Parent-Child Relations|Child Behavior Problem
Interventions: BEHAVIORAL: Improving Parenting Skills adult ADHD (IPSA)|OTHER: Continued Routine Services
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Performance and Safety of Sentinox in COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19 (SARS-CoV-2 Infection)
Interventions: DEVICE: Sentinox--Group A|DEVICE: Sentinox--Group B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Smoking Cessation in the Homeless Population
Status: COMPLETED
Conditions: Cigarette Smoking|Tobacco Smoking|Smoking, Tobacco
Interventions: DRUG: nicotine patch plus nicotine gum/lozenge|BEHAVIORAL: Intensive Alcohol Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Patients With Crohn's Disease Who Are Steroid Dependent, Despite Previous Unsuccessful Attempts to Reduce Steroids Due to Worsening of Crohn's Disease
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: Sargramostim (Leukine)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reliability of Dosing With NovoLog® Mix 70/30 FlexPen® Compared With Vial and Syringe
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Delivery Systems
Interventions: DEVICE: FlexPen®|DEVICE: vial and syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Risk of Squamous Cell Carcinoma on Skin Areas Treated With Ingenol Mebutate Gel, 0.015% and Imiquimod Cream, 5%
Status: COMPLETED
Conditions: Actinic Keratosis (AK)
Interventions: DRUG: Ingenol Mebutate Gel, 0.015%|DRUG: Imiquimod Cream, 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: fluorouracil|DRUG: oxaliplatin|PROCEDURE: conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib, Rituximab and Dexamethasone in Waldenstrom's Macroglobulinemia
Status: COMPLETED
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: Dexamethasone|DRUG: Carfilzomib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Successful Aging and Enrichment (SAGE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Health|Healthy Aging
Interventions: BEHAVIORAL: Cognitive Stimulation|BEHAVIORAL: Mindfulness training|BEHAVIORAL: Physical Activity|BEHAVIORAL: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The 8x5 Diet for Bile Acid Diarrhoea: A Feasibility Randomised Controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Bile Acid Diarrhea
Interventions: BEHAVIORAL: The 8x5 Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Ridaforolimus and Exemestane, Compared to Ridaforolimus, Dalotuzumab and Exemestane in Participants With Breast Cancer (MK-8669-064)
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Ridaforolimus|DRUG: Dalotuzumab|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Myofascial Release on Dysphagia in Parkinson's Disease Patients
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Rehabilitation treatment|BEHAVIORAL: Myofascial Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: TST001|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Paclitaxel|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bionic Pancreas in Children With Hyperinsulinism and Post-Pancreatectomy Diabetes
Status: COMPLETED
Conditions: Hyperinsulinism|Diabetes|Pancreatic Diseases|Pancreatectomy; Hyperglycemia
Interventions: DEVICE: Bihormonal Bionic Pancreas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Rucaparib With Other Anticancer Agents in Metastatic Castration Resistant Prostate Cancer Patients (RAMP)
Status: COMPLETED
Conditions: Metastatic Castration Resistant Prostate Cancer
Interventions: DRUG: Rucaparib|DRUG: Enzalutamide|DRUG: Abiraterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Camostat Mesilate on COVID-19 Infection
Status: UNKNOWN
Conditions: Corona Virus Infection
Interventions: DRUG: Camostat Mesilate|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia
Status: TERMINATED
Conditions: Cannabis Dependence|Marijuana Dependence
Interventions: DRUG: Dronabinol|DRUG: Clonidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Using Low-level Light Therapy to Treat Sleep and Psychological Symptoms Among Shift-work Nurses
Status: UNKNOWN
Conditions: Shift Work Type Circadian Rhythm Sleep Disorder
Interventions: DEVICE: use low level light therapy,The Dr.Tai's energy cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improvement of Cardiac Function in Patients With Ischemic Cardiomyopathy by Extracorporeal Shock Wave Therapy: a Multicenter Clinical Study
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DEVICE: Cardiac shock wave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Filgotinib in Combination With Methotrexate in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Filgotinib|DRUG: Placebo to match filgotinib|DRUG: Adalimumab|DRUG: Placebo to match adalimumab|DRUG: MTX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Patient Retention of Fingolimod vs. Currently Approved Disease Modifying Therapy in Patients With Relapsing Remitting Multiple Sclerosis.
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Fingolimod|DRUG: Disease Modifying therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of CG100649 in Osteoarthritis Patients
Status: COMPLETED
Conditions: Localized Primary Osteoarthritis of Hip|Localized Primary Osteoarthritis of Knee
Interventions: DRUG: CG100649|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DT01 Tablets in Patients With Irritable Bowel Syndrome With Diarrhea
Status: NOT_YET_RECRUITING
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: DT01 tablets|DRUG: Placebo tablets|DRUG: DT01-Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exercise Behavior Modification on Plasma Adiponectin and Insulin Resistance in High Risk Subjects of Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Physical activity promoting intervention|BEHAVIORAL: General instruction and education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits in Children
Status: COMPLETED
Conditions: Traumatic Brain Injury|Attention Deficit Disorder
Interventions: DRUG: Lisdexamfetamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Rule and Mechanism of Treating Functional Gastrointestinal Diseases From the Perspective of Liver and Spleen
Status: UNKNOWN
Conditions: Non-erosive Reflux Disease/Diarrheal Irritable Bowel Syndrome
Interventions: DRUG: tong-jiang granules|DRUG: Chang 'an II Recipe|DRUG: The placebo of tong-jiang granules|DRUG: The placebo of Chang 'an II Recipe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DZD1516 in Combination With Trastuzumab and Capecitabine, or in Combination With T-DM1, in Patients With Metastatic HER2 Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Metastatic
Interventions: DRUG: DZD1516 mono therapy in Part A, DZD1516 in combination with trastuzumab and/or capecitabine in Part B, DZD1516 in combination with T-DM1 in Part C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus
Status: RECRUITING
Conditions: Renal Cancer|Kidney Cancer|Renal Cell Carcinoma|Inferior Vena Cava Thrombosis
Interventions: DRUG: Axitinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Immune Response to a rAd5 HIV Vaccine Administered in Three Different Ways in Healthy, HIV-Uninfected Adults
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC rAd5 vaccine (rAd5 gag-pol/env A/B/C)|BIOLOGICAL: rAd5 env A|BIOLOGICAL: rAd5 env B|BIOLOGICAL: rAd5 env C|BIOLOGICAL: rAd5 gag-pol|BIOLOGICAL: Placebo Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Who Have Had an Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: peficitinib|DRUG: Placebo|DRUG: methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ALXN2050 in Adult Participants With Generalized Myasthenia Gravis
Status: TERMINATED
Conditions: Generalized Myasthenia Gravis|Myasthenia Gravis
Interventions: DRUG: ALXN2050|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy, Tretinoin, and Cyclophosphamide in Treating Patients With Metastatic Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: Vaccine Treatment|DRUG: Cyclophosphamide|DRUG: All-trans retinoic acid (ATRA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: isCGM With Education and Feedback for Non-Insulin Dependent Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Intermittently scanned continuous glucose monitor (isCGM)|BEHAVIORAL: Education and coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure
Status: RECRUITING
Conditions: Fetal Alcohol Spectrum Disorders|Fetal Alcohol Syndrome
Interventions: DIETARY_SUPPLEMENT: Choline bitartrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Early Occurrence of Hepatocellular Carcinoma (HCC) in Egyptian HCV Infected Patients Receiving Sofosbuvir and Daclatasvir
Status: UNKNOWN
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir 400 mg, Daclatasvir, Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acute Effects of High Intensity Training on Pain Processing and Inflammation in Chronic Low Back Pain.
Status: COMPLETED
Conditions: Low Back Pain|Inflammation
Interventions: OTHER: high intensity cardiorespiratory exercise protocol|OTHER: moderate intensity cardiorespiratory exercise protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Finerenone to Investigate a Paediatric Formulation in Healthy Male Subjects
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Finerenone (BAY94-8862): 20 mg intact tablet|DRUG: Finerenone (BAY94-8862): 20 mg crushed and resuspended tablet|DRUG: Finerenone (BAY94-8862): 20 mg suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Back Muscles Activation on Idiopathic Scoliosis Using Surface Electromyography
Status: COMPLETED
Conditions: Idiopathic Scoliosis
Interventions: BEHAVIORAL: gait with leg length discrepancy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylaxis for Aspiration of Gastric Contents.
Status: COMPLETED
Conditions: Pulmonary Aspiration of Gastric Contents
Interventions: DRUG: Drug either PPIS or H2RA and prokinetics|PROCEDURE: orogastric intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce S.Mutans
Status: COMPLETED
Conditions: White Spot Lesion of Tooth|Long Term Adverse Effects|Caries, Dental|Orthodontic Appliance Complication
Interventions: DRUG: Probiotic Toothpaste|DRUG: Dr. Reddy's Clohex|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects Of Combined Cryolipolysis And High Intensity Interval Training On Insulin Resistance And Body Composition In Polycystic Ovarian Patients
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Hyperinsulinism
Interventions: DEVICE: cryolipolysis(3 max cool shaping)|DEVICE: Treadmill (jkexer focus 8020A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label, Single Arm, Tumor Imaging and Dosimetry Study of I-124 PGN650 in Advanced Solid Tumors
Status: TERMINATED
Conditions: Malignant Solid Tumor
Interventions: DRUG: I-124 PGN650 for PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study Exploring the Effect of Music on Pain After Ventral Hernia Surgery
Status: COMPLETED
Conditions: Postoperative Pain, Acute|Ventral Hernia|Hernia Abdominal Wall|Surgery|Anxiety
Interventions: OTHER: Patient-Chosen Music|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Leg Stretching Using an Exoskeleton on Demand for People With Spasticity
Status: NOT_YET_RECRUITING
Conditions: Spasticity|Movement Disorders|Spinal Cord Injury
Interventions: DEVICE: Wearable Robotic Exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CS-1008 With Carboplatin/Paclitaxel in Chemotherapy naïve Subjects With Metastatic or Unresectable Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: CS-1008|DRUG: Placebo|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lateral Wedge Insole With Subtalar Strapping for Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Neutral insole with subtalar strapping (sham)|OTHER: Lateral wedge insole with subtalar strapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Remodulin in Patients With Critical Limb Ischemia With No Planned Revascularization Procedures
Status: TERMINATED
Conditions: Critical Limb Ischemia|Peripheral Vascular Disease|Foot Ulcers|Rest Leg Pain
Interventions: DRUG: Remodulin® (treprostinil sodium) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PoC Study to Evaluate the Efficacy and Safety of Secukinumab 300 mg in Patients With Lichen Planus
Status: COMPLETED
Conditions: Lichen Planus: Cutaneous Lichen Planus, Mucosal Lichen Planus and Lichen Planopilaris
Interventions: DRUG: secukinumab 300 mg Q4W|DRUG: secukinumab 300 mg Q2W|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Brexpiprazole in the Treatment of Borderline Personality Disorder
Status: COMPLETED
Conditions: Borderline Personality Disorder
Interventions: DRUG: Brexpiprazole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine Versus Beta-blockers, Angiotensin-converting Enzyme Inhibitors, and Statins for Prevention of Chemotherapy-Induced Cardiomyopathy
Status: NOT_YET_RECRUITING
Conditions: Chemotherapy Induced Systolic Dysfunction
Interventions: DRUG: Carvedilol|DRUG: Ramipril|DRUG: Rosuvastatin|DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Abexinostat in Chinese Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: Abexinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on OsseoSpeed™ TX Short Implants in a Chinese Population
Status: COMPLETED
Conditions: Partially Edentulous Jaw
Interventions: DEVICE: OsseoSpeed™ TX implant (Ø 4.0 mm, length 6 mm)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sevoflurane in Postoperative Troponin I Levels in Children Undergoing Congenital Heart Defects Surgery
Status: UNKNOWN
Conditions: Congenital Heart Defects
Interventions: DRUG: Sevoflurane|DRUG: TIVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Dual-site Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients
Status: RECRUITING
Conditions: Postoperative Cognitive Decline|Postoperative Delirium|Postoperative Cognitive Dysfunction
Interventions: BEHAVIORAL: Cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of Vx006 Vaccine in Solid Tumor Patients
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Vx-006: 0,5mg|DRUG: Vx-006: 1mg|DRUG: Vx-006: 5mg|DRUG: Vx-006: 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients
Status: COMPLETED
Conditions: Treatment for Basal Cell Carcinomas (BCCs) in Gorlin Syndrome Patients
Interventions: DRUG: Vehicle|DRUG: LDE225 0.25%|DRUG: LDE225 0.75%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cortical Stimulation by Direct Current for the Treatment of Chronic Pain : Pilot-study of a Stimulation Device at Home
Status: RECRUITING
Conditions: Neuropathic Pain
Interventions: DEVICE: tDCS (use at home)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Veliparib in Combination With Nivolumab and Platinum Doublet Chemotherapy in Participants With Metastatic or Advanced Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: pemetrexed|DRUG: nivolumab|DRUG: paclitaxel|DRUG: veliparib|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SHARE: Simple HAART With Abacavir, Reyataz, and Epivir
Status: UNKNOWN
Conditions: HIV Infections|Lipodystrophy
Interventions: DRUG: atazanavir (Reyataz)|DRUG: ritonavir (Norvir)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The YourMove Study: Optimizing Individualized and Adaptive mHealth Interventions Via Control Systems Engineering Methods
Status: ACTIVE_NOT_RECRUITING
Conditions: Inactivity, Physical|Sedentary Behavior
Interventions: BEHAVIORAL: COT-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aerobic Exercise Intervention in Adolescents With Attention-deficit/Hyperactivity Disorder (ADHD)
Status: RECRUITING
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: OTHER: Aerobic exercise|OTHER: Video-watching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Palmoplantar Pustulosis
Status: COMPLETED
Conditions: Palmoplantar Pustulosis
Interventions: BIOLOGICAL: Imsidolimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Systematic Empirical vs. Test-guided Anti-TB Treatment Impact in Severely Immunosuppressed HIV-infected Adults Initiating ART With CD4 Cell Counts <100/mm3
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DEVICE: Xpert MTB/RIF®, Determine TB LAM, Chest X-ray|DRUG: ART (Atripla, Truvada, Efavirenz, Combivir)|DRUG: Rifampin, isoniazid, pyrazinamide, ethambutol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Overlapping Pain Trajectory Study
Status: RECRUITING
Conditions: Migraine|Musculoskeletal Pain|Functional Abdominal Pain Disorders|Chronic Pain|Widespread Chronic Pain|Low Back Pain|Healthy Volunteers
Interventions: OTHER: Conditioned Pain Modulation|OTHER: Offset Analgesia|OTHER: Spatial Summation|OTHER: Temporal Summation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate the Safety, Tolerability, PK and PD of MG1113 in Healthy Subjects and Hemophilia Patients
Status: COMPLETED
Conditions: Hemophilia
Interventions: BIOLOGICAL: MG1113|OTHER: Placebo of MG1113
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility
Status: UNKNOWN
Conditions: Primary Infertility Unspecified|Infertility|Ovarian Hyperstimulation|Pregnancy
Interventions: PROCEDURE: Hysteroscopy|DEVICE: Hysteroscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics and Bioequivalence of Two Empagliflozin, With Evaluation in Healthy Jordanian Subjects Under Fasting and Fed Conditions
Status: COMPLETED
Conditions: Pharmacokinetic Parameters
Interventions: DRUG: Empagliflozin 10 mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Providing Speech Therapy Awareness in Private Schools
Status: COMPLETED
Conditions: Speech and Language Disorder|Speech Therapy|Speech Delay|Swallowing Disorder|Acquired Language Disorders|Developmental Delay Disorder|Stuttering|Hearing Impairment|Head and Neck Cancer
Interventions: OTHER: Speech-Language Pathology Presentation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Incidence of Various Types of Systemic Reactions Related to Spinal Steroid Injection: A Prospective Study
Status: COMPLETED
Conditions: Incidence and Types of Systemic Reactions Occurring After Spinal Steroid Injection in a Large Population
Interventions: DRUG: Spinal Steroid Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gingival Augmentation and Root Coverage With Superficial and Deep Cut Acellular Dermal Matrices
Status: TERMINATED
Conditions: Gingival Recession
Interventions: OTHER: Allograft Material ADM-S|OTHER: Allograft Material ADM-D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyaluronic Acid With Scaling & Root Planing In Chronic Periodontitis Patients With Diabetes Mellitus Type 2
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: PROCEDURE: Periodontal treatment with Hyaluronic acid associated with SRP|PROCEDURE: Scaling & root planning alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center Trial of Nepicastat for Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: Nepicastat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Safety and Effectiveness Trial of Dapivirine Vaginal Ring for Prevention of HIV-1 in Women
Status: COMPLETED
Conditions: HIV Infections
Interventions: COMBINATION_PRODUCT: Dapivirine Vaginal Ring|COMBINATION_PRODUCT: Placebo Ring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of the Efficacy of Platelet-rich Fibrin and Connective Tissue Graft in Interdental Papilla Reconstruction
Status: COMPLETED
Conditions: To Evaluate the Efficacy of Platelet-rich Fibrin in Papilla Reconstruction|To Evaluate the Efficacy of Connective Tissue Graft in Papilla Reconstruction
Interventions: OTHER: retrospective data analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy
Status: RECRUITING
Conditions: Malignant Brain Neoplasm
Interventions: OTHER: Best Practice|OTHER: Medical Device Usage and Evaluation|DRUG: Metformin|OTHER: Neurocognitive Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Nasulin Versus Placebo on Blood Glucose Control in Patient Volunteers With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: Placebo for Nasulin|DRUG: Nasulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mid-Q Response Study
Status: COMPLETED
Conditions: Heart Failure|Left Bundle-Branch Block|Heart Failure With Reduced Ejection Fraction (HFrEF)|Heart Failure NYHA Class II|Heart Failure NYHA Class III|Heart Failure NYHA Class IV
Interventions: DEVICE: aCRT ON|DEVICE: aCRT OFF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase-3 Study of ASP7374, Cell-culture-derived Influenza Vaccine
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: ASP7374|BIOLOGICAL: approved egg-derived TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Postoperative Pain After Tension-free Obturator Tape Operation (TVT-O) With or Without Local Anesthetic
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DRUG: Marcaine 0.5 % Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder
Status: COMPLETED
Conditions: Alcohol Use Disorder|Alcoholism|Alcohol Addiction
Interventions: DRUG: Oxytocin nasal spray|DRUG: Naltrexone Pill|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thiamine Intervention and Coronary Artery Bypass Grafting
Status: RECRUITING
Conditions: Coronary Heart Disease|Coronary Artery Bypass Grafting
Interventions: DIETARY_SUPPLEMENT: Thiamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT
Status: RECRUITING
Conditions: Acute Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndromes|Acute Lymphoblastic Leukemia|Mixed Lineage Leukemia|Lymphoblastic Lymphoma|Burkitt Lymphoma|Juvenile Myelomonocytic Leukemia
Interventions: DEVICE: CliniMACS Cell Processing System for TCRαβ + T Cell and CD45RA Depleted Peripheral Stem Cell Addback
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video Laryngoscopy vs Direct Laryngoscopy in Paediatric Patients
Status: NOT_YET_RECRUITING
Conditions: Endotracheal Tube Wrongly Placed During Anesthetic Procedure
Interventions: DEVICE: Video Laryngoscope|DEVICE: Direct laryngoscope
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Effect of Early Palliative Care on Quality of Life of Patients With Advanced Cancer: a Randomised Controlled Trial.
Status: COMPLETED
Conditions: Life-limiting Cancer With Prognosis of Approximately 1 Year
Interventions: BEHAVIORAL: Interventional palliative care|BEHAVIORAL: Standard oncologic care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Transit
Status: RECRUITING
Conditions: Gastrointestinal Motility
Interventions: DIAGNOSTIC_TEST: Contrast-enhanced multispectral optoacoustic tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: FCM Versus R-FCM Followed by R-Maintenance or Observation Only
Status: UNKNOWN
Conditions: Lymphoma, Follicular|Lymphoma, Low-Grade|Lymphoma, Intermediate-Grade
Interventions: PROCEDURE: FCM|PROCEDURE: R-FCM|DRUG: rituximab maintenance|OTHER: observation only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restylane Refyne for Correction of Horizontal Neck Rhytides
Status: ACTIVE_NOT_RECRUITING
Conditions: Aging|Wrinkle|Rhytides
Interventions: DEVICE: Restylane Refyne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT