pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Platinum Sensitive|BRCA Mutated|Relapsed Ovarian Cancer|Following Complete or Partial Response to Platinum Based Chemotherapy
Interventions: DRUG: Olaparib 300mg tablets|DRUG: Placebo to match olaparib 300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of 6-month Duration of Dual Antiplatelet Therapy After Acute Coronary Syndromes (SMART-DATE)
Status: UNKNOWN
Conditions: Acute Coronary Syndrome
Interventions: DRUG: P2Y12 inhibitor (clopidogrel, ticagrelor, prasugrel)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation Plus Durvalumab Followed by Surgery Followed by Adjuvant Durvalumab in Patients With Surgically Resectable Stage III (N2) Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Stage III Non-small-cell Lung Cancer
Interventions: DEVICE: Durvalumab|DRUG: Paclitaxel|DRUG: Carboplatin|RADIATION: Radiation|PROCEDURE: Surgical Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12/24-weeks, Open, Multi-centre, Phase IV Study on Safety and Efficacy of 2mg Exenatide Once Weekly (Bydureon) in T2DM Patients.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: Bydureon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The cryoICE™ CryoAnalgesia Study For Pain Management in Post thoRacic Procedures Via intercOSTal Cryoanalgesia (FROST)
Status: COMPLETED
Conditions: Pain
Interventions: DEVICE: Cryoanalgesia|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-intensity Exercise After Acute Cardiac Event (HITCARE)
Status: TERMINATED
Conditions: Unstable Angina Pectoris|Acute Myocardial Infarction|Recurrent Myocardial Infarction
Interventions: BEHAVIORAL: High-intensity aerobic interval training, short interval|BEHAVIORAL: High-intensity aerobic interval training, long interval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Status: RECRUITING
Conditions: Obesity|Hypertension
Interventions: DRUG: Angiotensin-(1-7)|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Suprachoroidal Triamcinolone Versus Posterior Subtenon Triamcinolone Alone or Formulated in the Management of Diabetic Macular Edema.
Status: COMPLETED
Conditions: Diabetic Macular Edema of Left Eye
Interventions: DRUG: Triamcinolone Acetonide|DRUG: Formulated Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thoracic Spine Thrust Manipulation for Cervicogenic Headaches: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Headache Disorders, Secondary
Interventions: PROCEDURE: Thoracic manipulation (Manipulation Group)|PROCEDURE: Thoracic Manipulation (Control wait-list)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-blind, Multi-center, Multi-national Trial to Evaluate the Efficacy, Safety, and Immunogenicity of SAIT101 Versus Rituximab as a First-line Immunotherapy Treatment in Patients With Low Tumor Burden Follicular Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Follicular
Interventions: BIOLOGICAL: SAIT101|BIOLOGICAL: MabThera®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Azilsartan Medoxomil in African American Participants With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan medoxomil|DRUG: Azilsartan medoxomil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of West Nile Virus With MGAWN1
Status: TERMINATED
Conditions: West Nile Neuroinvasive Disease|West Nile Virus Infection|Encephalitis|Meningitis|Acute Flaccid Paralysis|West Nile Fever
Interventions: BIOLOGICAL: MGAWN1|BIOLOGICAL: Placebo - normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MEK Inhibitor and a PDL1 Inhibitor Patients With Locally Advanced and/or Metastatic Soft Tissue Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcoma,Soft Tissue
Interventions: DRUG: Cobimetinib|DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Body Composition Changes After TIPS and Associated Clinical Outcomes
Status: RECRUITING
Conditions: Cirrhosis, Liver|Sarcopenia
Interventions: PROCEDURE: Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MDX-010 Antibody, MDX-1379 Melanoma Vaccine, or MDX-010/MDX-1379 Combination Treatment for Patients With Unresectable or Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma|Metastases
Interventions: DRUG: MDX-010 (anti-CTLA4) monoclonal antibody|BIOLOGICAL: MDX-1379 (gp100) Melanoma Peptide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML)
Status: TERMINATED
Conditions: Relapsed Acute Myelogenous Leukemia
Interventions: DRUG: Clofarabine|DRUG: Etoposide|DRUG: Cyclophosphamide|DRUG: Filgrastim|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in T1DM Children
Status: COMPLETED
Conditions: Hypoglycemia
Interventions: DRUG: dasiglucagon|DRUG: placebo|DRUG: GlucaGen HypoKit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Core Stabilization and Dynamic Stretching Exercises in Primary Dysmenorrhea
Status: RECRUITING
Conditions: Primary Dysmenorrhea
Interventions: OTHER: Stretching Exercises|OTHER: Dynamic core stabilizing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: ivermectin|DRUG: placebo|DRUG: dihydroartemisinin-piperaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Hormone-Sensitive Prostate Cancer
Interventions: DRUG: Capivasertib|OTHER: Placebo|DRUG: Abiraterone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Oral Haloperidol Tablets Formulations in Healthy Subjects Under Fed Conditions
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Haloperidol Tablets, Mylan Pharmaceuticals Inc.|DRUG: Haloperidol Tablets, Cycle Pharmaceuticals Ltd
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reduced-Intensity Conditioning Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Refractory Multiple Myeloma
Interventions: DRUG: fludarabine phosphate|DRUG: melphalan|RADIATION: total-body irradiation|DRUG: mycophenolate mofetil|DRUG: cyclosporine|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: smoked plum|DRUG: gum chewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gefitinib and Celecoxib in Treating Patients With Refractory Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Celecoxib|DRUG: ZD1839
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of GSK Biologicals' HBV-MPL Vaccine (2 Doses), and of Engerix™-B (3 Doses) in Healthy Adults
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B|BIOLOGICAL: HBV-MPL vaccine 208129
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase 2 Trials of NA-931 to Study Subjects Who Are Obese With at Least One Weight-related Comorbid Condition
Status: RECRUITING
Conditions: Weight Loss|Obesity|Body Weight|Body Weight Changes
Interventions: DRUG: Drug: Placebo daily and orally|DRUG: NA-931, dose 1, daily and orally|DRUG: NA-931, dose2, daily and orally|DRUG: NA-931 dose 3, daily and orally|DRUG: NA-931 dose 4, daily and orally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fluoroscopically-guided Versus Landmark-guided Sacroiliac Joint Injections
Status: COMPLETED
Conditions: Sacroiliac Joint Pain
Interventions: PROCEDURE: X-ray SI joint steroid injection|PROCEDURE: Landmark-guided SI steroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Nexstim SNBT System
Status: ENROLLING_BY_INVITATION
Conditions: Usability of the Graphical User Interface of the Device for Its Intended Use
Interventions: DEVICE: Nexstim SNBT use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Automated Stereognosis to Treat Loss of Tactile Function After Brain Injury
Status: TERMINATED
Conditions: Stroke|Chronic Brain Injury|Peripheral Neuropathy
Interventions: DEVICE: ReTrieve Automated Stereognosis System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Cyclophosphamide and Prednisone in Treating Older Patients With Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: carmustine|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: melphalan|DRUG: prednisone|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Trauma-informed Cognitive Behavioural Therapy (TiCBT) to Aid Reintegration of Repentant Terrorists and Their Families in Nigeria: A Pilot Study
Status: UNKNOWN
Conditions: Trauma|Psychological
Interventions: BEHAVIORAL: Trauma-informed Cognitive Behaviour Therapy (TiCBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Epicutaneous Immunotherapy in Peanut Allergy in Children
Status: COMPLETED
Conditions: Peanut Allergy
Interventions: BIOLOGICAL: Epicutaneous Immunotherapy|BIOLOGICAL: placebo of peanut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infusional Fluorouracil and Weekly Docetaxel for Gastric Cancer With Bone Marrow Involvement and DIC
Status: COMPLETED
Conditions: Gastric Cancer|Bone Marrow Metastasis|Disseminated Intravascular Coagulation
Interventions: DRUG: 5-fluorouracil|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-course Radiotherapy Combined With CAPOX and PD-1 Antibody Versus Long-course Chemoradiotherapy Combined With CAPOX for Early Low-lying Rectal Cancer
Status: RECRUITING
Conditions: Early Low Rectal Cancer
Interventions: RADIATION: Short-course radiotherapy|DRUG: PD-1 antibody (Toripalimab)|RADIATION: Long-course radiotherapy|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAK-228 and TAK-117 Followed by Cisplatin and Nab Paclitaxel for Metastatic Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Tak-228 & Tak-117|DRUG: Cisplatin & Nab Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PCMS Task After Moderate-to-severe Stroke
Status: SUSPENDED
Conditions: Stroke
Interventions: DEVICE: Task-specific PCMS|DEVICE: Task-specific sham-PCMS|DEVICE: PCMS-rest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ischemic Preconditioning, Exercise Tolerance and Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: Ischemic Preconditioning|OTHER: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: SBRT Combined With PD-1 Inhibitor and Thoracic Hyperthermia for Advanced NSCLC
Status: RECRUITING
Conditions: Stereotactic Body Radiation Therapy; PD-1 Inhibitor; Hyperthermia; NSCLC
Interventions: RADIATION: SBRT combined with PD-1 inhibitors and thoracic hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in MPS VI to Assess Safety and Efficacy of Odiparcil
Status: COMPLETED
Conditions: Mucopolysaccharidosis VI
Interventions: DRUG: Odiparcil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms Underlying Predictors of Success From Obesity Surgery
Status: WITHDRAWN
Conditions: Obesity
Interventions: DRUG: Exendin 9-39 and Sitagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Status: RECRUITING
Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries|Obese
Interventions: DRUG: Semaglutide Injectable Product (Wegovy and/or Ozempic)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Effects and Predictive Models of Contemporary Upper Limb Training Programs in Stroke Patients
Status: COMPLETED
Conditions: Cerebrovascular Accidents
Interventions: OTHER: Hospital-based mCIT|OTHER: Hospital-based BIT|OTHER: Hospital-based TR|OTHER: Home-based mCIT|OTHER: Home-based BAT|OTHER: Home-based TR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Subarachnoid Hemorrhage, Aneurysmal|Intracerebral Hemorrhage|Traumatic Brain Injury
Interventions: OTHER: None (observational)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Cutaneous Leishmaniasis
Status: COMPLETED
Conditions: Leishmaniasis, Cutaneous
Interventions: BIOLOGICAL: Leish-111f + MPL-SE vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Breastfeeding Education Using a Doll During Pregnancy on Newborn Feeding
Status: ACTIVE_NOT_RECRUITING
Conditions: Breastfeeding Education|Newborn; Vitality|Education
Interventions: BEHAVIORAL: Using dolls in breastfeeding education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Aerobic Interval and Inspiratory Muscle Training On Patient Reported Outcome Scores In Individuals With Chronic Constipation
Status: WITHDRAWN
Conditions: Constipation|Constipation by Outlet Obstruction|Constipation-predominant Irritable Bowel Syndrome|Constipation - Functional
Interventions: OTHER: Standard Physical Therapy Care|OTHER: Aerobic and Inspiratory Muscle Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying the Effect of Dialysate Temperature on Toxin Removal and Hypotension
Status: COMPLETED
Conditions: Dialysis Amyloidosis|Hypotension
Interventions: PROCEDURE: Cool dialysate|PROCEDURE: Warm dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metabolic Risk Management, Physical Exercise and Lifestyle Counselling in Low-active Adults; Controlled Randomized Trial
Status: COMPLETED
Conditions: Metabolic Syndrome X|Lifestyle-related Condition|Lifestyle Risk Reduction|Cardiovascular Risk Factor
Interventions: BEHAVIORAL: Lifestyle|BEHAVIORAL: Aerobic interval training|BEHAVIORAL: Traditional continous training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Trial of Triheptanoin in Patients With Glucose Transporter Type-1 Deficiency Syndrome
Status: COMPLETED
Conditions: Glucose Transporter Type-1 Deficiency Syndrome (Glut1 DS)
Interventions: DRUG: Triheptanoin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis
Status: UNKNOWN
Conditions: Cryptococcal Meningitis
Interventions: DRUG: Liposomal amphotericin B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of CD19 Specific T Cells in CD19 Positive Malignancy
Status: TERMINATED
Conditions: CD19 Positive Non-Hodgkin Lymphoma
Interventions: GENETIC: aCD19z cells, IL2, pre conditioning Cyclophosphamide & Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent and Platelet AggregatioN studIeS for TreatMent of Acute Myocardial InfarctionTreatment of ST-elevation Acute Myocardial Infarction
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: cobalt-chromium everolimus-eluting stent (CoCr-EES)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epirubicin and Cyclophosphamide Compared With Epirubicin and Paclitaxel in Treating Women With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: epirubicin hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: HORizontal Instability AC Joint Study: A Prospective Randomised Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Acromioclavicular Separation
Interventions: PROCEDURE: non-absorbable tape fixation around AC joint|PROCEDURE: no fixation around AC joint|PROCEDURE: coracoclavicular (CC) fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Erector Spinae Plane Block for Painless 1st Stage Normal Vaginal Delivery: Randomized Controlled Study
Status: UNKNOWN
Conditions: Numerical Rating Pain Score|the Total Doses of Pethidine Needed Through-out Delivery Will be Measured|the Incidence of Failed Delivery and Need of Cesarean Section Will be Assessed|the Incidence of Transient Fetal Bradycardia or Deceleration After the Administration of the Block Will be Recorded|ABGAR Score of the Neonate
Interventions: PROCEDURE: bilateral erector spinae plane block at T11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of Denosumab CP4 Drug Product and Commercially Available Denosumab CP2 Drug Product
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Denosumab CP4|DRUG: Denosumab CP2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Support, Educate, Empower (SEE) Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Glaucoma
Interventions: BEHAVIORAL: Personalized Glaucoma Coaching|BEHAVIORAL: Enhanced Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS
Status: UNKNOWN
Conditions: Cryptococcal Meningitis
Interventions: DRUG: Fluconazole|DRUG: Antiretroviral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Elimination of Protein-bound Uremic Retention Solutes by Prometheus Artificial Hepatic System Versus Conventional Dialysis
Status: WITHDRAWN
Conditions: Renal Failure, Chronic
Interventions: DEVICE: Dialysis with different artificial devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ProAliFun_6.7_Health Effects of a Low-Salt Bread on Hypertensive Subjects (ProAliFun67)
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: Low-sodium diet with standard bread|DIETARY_SUPPLEMENT: Low-sodium diet with low-sodium bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HPV Vaccine Effectiveness Study in Rwandan Women Living With HIV
Status: RECRUITING
Conditions: Cervical Cancer|Human Papilloma Virus|Human Immunodeficiency Virus|HPV-Related Carcinoma
Interventions: PROCEDURE: Blood collection|PROCEDURE: Oral, cervicovaginal and anal specimen collection|PROCEDURE: Anoscopy & Biopsy of Acetowhite Lesions|PROCEDURE: Colposcopy & Biopsy of Acetowhite Lesions|PROCEDURE: Ablative Treatment|PROCEDURE: LEEP (Loop Electrosurgical Excision Procedure)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer|Neoadjuvant Chemotherapy
Interventions: DRUG: Capox chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Performance of Center Distance Daily Disposable Multifocal Lenses
Status: RECRUITING
Conditions: Myopia
Interventions: DEVICE: NaturalVue Enhanced Multifocal 1 Day contact lens|DEVICE: MiSight 1 Day contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers
Status: NOT_YET_RECRUITING
Conditions: Huntington Disease
Interventions: DRUG: NAC|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair
Status: UNKNOWN
Conditions: Hernia, Ventral|Body Image|Respiratory Function Tests|Quality of Life|Laparoscopy
Interventions: PROCEDURE: Laparoscopic repair|PROCEDURE: Open midline incisional hernia repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilization of Physical Activity Recommendations Among Patients of Cardiovascular Healthcare Centres in Eastern Slovakia
Status: WITHDRAWN
Conditions: Cardiovascular Diseases
Interventions: BEHAVIORAL: The EAPC Exercise Prescription (EXPERT) Tool|BEHAVIORAL: Standard Cardio-Care Lifestyle Counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Does The Surfactant Administration by Aerosolization Effective?
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome|Surfactant Administration by Aerosolization
Interventions: DRUG: surfactant|DEVICE: nasal continuous positive airway pressure|DEVICE: non-invasive intermittent positive-pressure ventilation|DEVICE: Neopuff|DEVICE: neonatal ventilator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia.
Status: RECRUITING
Conditions: Familial Hypercholesterolemia|Nutrition, Healthy|Cholesterol, Elevated|Cholesterol; Metabolic Disorder|Cardiovascular Diseases
Interventions: OTHER: Canada's Food Guide principles (CFG diet)|OTHER: Standard North American diet (NAD diet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Results From a 24 Week Trial of EMDR Combined With Venlafaxine XR
Status: WITHDRAWN
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: Venlafaxine XR|BEHAVIORAL: EMDR|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement
Status: RECRUITING
Conditions: Osteo Arthritis Knee|Gonarthrosis
Interventions: PROCEDURE: Single-shot adductor canal block|PROCEDURE: Continuous femoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Topography Study 2018
Status: COMPLETED
Conditions: Cigarette Smoking|Smoking Behavior|Cigarette Smoking Toxicity
Interventions: BEHAVIORAL: Marlboro|BEHAVIORAL: Marlboro Prime|BEHAVIORAL: Marlboro Prime (ventilation holes taped)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: HDR Focal: Feasibility Study
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: targeted focal HDR brachytherapy|RADIATION: Whole-gland HDR Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Imaging (MRI) in Amyotrophic Lateral Sclerosis (ALS)
Status: WITHDRAWN
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DEVICE: 7 Tesla MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Postoperative Pain After Pediatric Umbilical Hernia Repair
Status: COMPLETED
Conditions: Pediatric Postoperative Pain
Interventions: PROCEDURE: bilateral ultrasound-guided rectus sheath block|PROCEDURE: Wound infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study HB-201 in Patients With Newly Diagnosed HPV16+ Oropharynx or Locally Advanced Cervical Cancer
Status: TERMINATED
Conditions: HPV 16+ Confirmed Oropharynx Cancer and Cervical Cancer
Interventions: DRUG: HB-201 IV|DRUG: HB-201 IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MRG002 in the Treatment of Patients With HER2-low Locally Advanced or Metastatic Breast Cancer (BC)
Status: UNKNOWN
Conditions: Advanced or Metastatic Breast Cancer
Interventions: DRUG: MRG002
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Oral Dose Study and a Treatment Schedule-finding Study in Non-elderly, Healthy Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of ASP3325 in Non-elderly, Healthy Adult Japanese Male and Female, and Caucasian Male Subjects
Interventions: DRUG: ASP3325|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Study to Assess the Efficacy and Safety of Different Doses of BIM 23A760 in Patients With Carcinoid Syndrome
Status: TERMINATED
Conditions: Carcinoid Syndrome
Interventions: DRUG: BIM 23A760
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)
Status: RECRUITING
Conditions: Pilon Fracture
Interventions: DRUG: N-acetylcysteine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Correlations of 3D Urethral and Paraurethral Sonographic Findings With Urodynamic Studies, Lower Urinary Tract Symptoms & Sexual Dysfunction in Female Patients With Lower Urinary Tract Symptoms.
Status: COMPLETED
Conditions: Lower Urinary Tract Dysfunction|Overactive Bladder Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique
Status: NOT_YET_RECRUITING
Conditions: Malaria,Falciparum|Chemoprevention
Interventions: DRUG: Sulfadoxine/pyrimethamine plus amodiaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients
Status: UNKNOWN
Conditions: Recurrent Mouth Ulcers
Interventions: DRUG: omega-3|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Regulation-Focused Psychotherapy (RFP-C)
Status: ACTIVE_NOT_RECRUITING
Conditions: Childhood Externalizing Disorder|Childhood Oppositional Defiant Disorder|Childhood Conduct Disorder
Interventions: BEHAVIORAL: Regulation Focused Psychotherapy (RFP-C)|BEHAVIORAL: Parental Awareness and Child Social Skills Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindful Physiology: A College Biology Course With Integrated Mindfulness
Status: ACTIVE_NOT_RECRUITING
Conditions: Mindfulness|Stress Psychological|Stress, Physiological
Interventions: BEHAVIORAL: Biology Course with Integrated Mindfulness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Vitamin D Supplementation on Insulin Sensitivity and Secretion
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Durvalumab for Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: Durvalumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes of PFA Vs. RFA for Patients With PSVT: a Retrospective and Propensity Score Matching Study
Status: RECRUITING
Conditions: Paroxysmal Supraventricular Tachycardia|Catheter Ablation
Interventions: PROCEDURE: Focal Pulsed Field Ablation (PFA)|PROCEDURE: Focal Radiofrequecy Ablation (RFA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TDM-based Infliximab Treatment for Active Perianal Fistulizing Crohn's Disease
Status: RECRUITING
Conditions: Crohn Disease|Infliximab|Perianal Fistula Due to Crohn's Disease|Therapeutic Drug Monitoring|Magnetic Resonance Novel Index for Fistula Imaging in Crohn's Disease Score
Interventions: DRUG: TDM-based infliximab intravenous therapy|DRUG: Standard infliximab intravenous therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma
Status: COMPLETED
Conditions: Newly-diagnosed Glioblastoma
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nitrous Oxide: A Dose-Response Analysis - 5
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: 10% N2O|DRUG: 20% N2O|DRUG: 30% N2O|DRUG: 40% N2O
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Dealcoholized Muscadine Wine and Skin Health in Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Health
Interventions: OTHER: Dealcoholized Muscadine Wine|OTHER: Control Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study To Assess Efficacy, Safety, Tolerability And Pharmacokinetics Of PF-07038124 Ointment In Participants With Atopic Dermatitis Or Plaque Psoriasis
Status: COMPLETED
Conditions: Atopic Dermatitis|Plaque Psoriasis
Interventions: DRUG: PF-07038124 ointment|DRUG: Vehicle ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High (100mg) Versus Standard (60mg) Loading Dose of Prasugrel in Patients With ST-elevation Myocardial Infarction (STEMI), Undergoing Primary Percutaneous Coronary Intervention (PCI)
Status: COMPLETED
Conditions: Platelet Reactivity
Interventions: DRUG: Prasugrel 100mg loading dose|DRUG: Prasugrel 60mg loading dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of N-acetyltransferase2 (NAT2) and Cytochrome P4502E1 (CYP2E1) Gene as Susceptible Risk Factors for Antituberculosis (ATT) Induced Hepatitis
Status: COMPLETED
Conditions: Pulmonary Tuberculosis
Interventions: DRUG: ATT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning (TheraPPP) Pathway
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Hypoxemic Respiratory Failure|ARDS, Human
Interventions: OTHER: TheraPPP Pathway
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Plasma (PRP) for Facet Mediated Lumbar Low Back Pain
Status: RECRUITING
Conditions: Facet Joint Pain; Low Back Pain
Interventions: PROCEDURE: Platelet Rich Plasma injection to the lumbar facet joint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Melanoma Markers in Lymph Nodes or Peripheral Blood of Patients With Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: GENETIC: reverse transcriptase-polymerase chain reaction|PROCEDURE: sentinel lymph node biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: DCC-2618|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice
Status: COMPLETED
Conditions: Pediculosis
Interventions: DRUG: Spinosad|DRUG: Spinosad|DRUG: Permethrin 1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2
Status: NOT_YET_RECRUITING
Conditions: Food Insecurity|Implementation Science|Diet, Healthy|Behavioral Economics
Interventions: BEHAVIORAL: Behavioral economics-enhanced SWAP implementation|BEHAVIORAL: Basic SWAP implementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Perioperative Administration of Dexamethasone on Postoperative Complications and Mortality After Non-cardiac Major Surgery
Status: COMPLETED
Conditions: Major Non-cardiac Surgery
Interventions: DRUG: Dexamethasone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of the Uterine Abnormalities Missed in an Ultrasound Scan and/or Hysterosalpingography Using Hysteroscopy, in Females Presenting With Unexplained Infertility
Status: COMPLETED
Conditions: Infertility, Female
Interventions: DIAGNOSTIC_TEST: office micro hysteroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety Study of Calcineurin-Inhibitor-Free Immunosuppression After Liver Transplantation
Status: UNKNOWN
Conditions: Liver Transplantation|Chronic Renal Insufficiency
Interventions: DRUG: Basiliximab (Simulect)|DRUG: Myfortic|DRUG: everolimus|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Extended high dose letrozole regimen /GnRH antagonist protocol|DRUG: Short low dose letrozole regimen /GnRH antagonist protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Efficacy and Safety in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DRUG: LDE225
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phosphodiesterase 5 Inhibitors (PDE5i) (Sildenafil) as Medical Expulsive Therapy in Distal Ureteral Stones
Status: UNKNOWN
Conditions: Ureteral Stone|Urolithiasis
Interventions: DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Surgical Management of Complex Intracranial Aneurysms With Hybrid Operating Techniques
Status: UNKNOWN
Conditions: Intracranial Aneurysm
Interventions: PROCEDURE: Hybrid Operating Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunologic Memory (Supp. of ATN 024)
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: Engerix B|BIOLOGICAL: Twinrix for ATN 024|BIOLOGICAL: Recombivax|BIOLOGICAL: Twinrix for ATN 025
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Selective Serotonin Reuptake Inhibitor (SSRI) Treatment on Affective Symptoms and Fertility Treatment Outcome in Women Undergoing in Vitro Fertilization (IVF)
Status: UNKNOWN
Conditions: Depression|Anxiety|In Vitro Fertilization
Interventions: DRUG: escitalopram|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: N-methylglycine (Sarcosine) Treatment for Depression
Status: COMPLETED
Conditions: Major Depressive Disorder|Depression|Major Depression
Interventions: DRUG: citalopram|DRUG: sarcosine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two-way Crossover Study in Healthy Male and Female Subjects to Evaluate the Bioequivalence of Jentadueto®.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin|DRUG: Linagliptin|DRUG: Metformin|DRUG: Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Chemotherapy Combined With Toripalimab in Locoregionally-Advanced Laryngo-Hypopharyngeal Squamous Cell Cancer
Status: UNKNOWN
Conditions: Locoregionally Advanced Laryngo-hypopharyngeal Squamous Cell Cancer
Interventions: DRUG: 5-Fluorouracil, Cisplatin, Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Specific Phenolic Compound on Blood Pressure
Status: UNKNOWN
Conditions: Cardiovascular Risk Factors|Blood Pressure
Interventions: DIETARY_SUPPLEMENT: placebo|DIETARY_SUPPLEMENT: phenolic compound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Statin Therapy in Young Adult Survivors of Childhood Cancer
Status: COMPLETED
Conditions: Cardiovascular Disease|Childhood ALL|Childhood NHL
Interventions: DRUG: Atorvastatin|DRUG: Sugar Pill (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacologic Effect for Female Overactive Bladder Syndrome: Mirabegron Versus Solifenacin
Status: RECRUITING
Conditions: Overactive Bladder Syndrome
Interventions: DRUG: Mirabegron|DRUG: Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT