pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: CSD190203: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting
Status: COMPLETED
Conditions: Smoking|Smoking Behaviors|Tobacco Use|Tobacco Smoking
Interventions: OTHER: CSD1902-11|OTHER: CSD1902-12|OTHER: CSD1902-13|OTHER: CSD1902-14|OTHER: CSD1902-21|OTHER: CSD1902-22|OTHER: CSD1902-23|OTHER: CSD1902-24
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Simultaneous Quantification of Liver Fat Content, Fatty Acid Composition, and Fibrosis Using Spin-lock MRI for Steatohepatitis Assessment
Status: NOT_YET_RECRUITING
Conditions: Non-alcoholic Fatty Liver Disease (NAFLD)|Non-alcoholic Steatohepatitis (NASH)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiofrequency Ablation vs Sham Procedure for Symptomatic Cervical Inlet Patch
Status: UNKNOWN
Conditions: Barrett Esophagus
Interventions: PROCEDURE: Radiofrequency ablation (RFA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biobehavioral Effects of Therapy Dog Visitation in Elderly Intensive Care Unit Patients: A Pilot and Feasibility Study
Status: COMPLETED
Conditions: Psychosocial Stress
Interventions: BEHAVIORAL: Therapy dog visitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of the Care Coordination, Assessment, and Responsive Engagement Program for Transition-aged Adolescents (t-CARE) With ASD
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Care Coordination Visit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Genetic Mutation in Epithelial Ovarian Cancer
Status: UNKNOWN
Conditions: Epithelial Ovarian Cancer|Nucleotide Variant|Copy Number Variation|Insertion-deletion Variation|Genomic Structural Variation|Total Mutation Burden|Microsatellite Instability|PD-1|PD-L1
Interventions: DIAGNOSTIC_TEST: A multi-gene panel testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Novel Walking Cane With Haptic Biofeedback Reduces Degenerative Loading in the Arthritic Knee
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Haptic cane|DEVICE: typical cane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Glycemic Impact of Oatmeal Plus OatWellXF28
Status: COMPLETED
Conditions: Glycemic Responses
Interventions: OTHER: Oatmeal + OatWell28XF|OTHER: Oatmeal|OTHER: Hot cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Glucoside- and Rutinoside-rich Crude Material for Relieving Side Effects of COVID-19 Vaccines
Status: UNKNOWN
Conditions: Vaccine Adverse Reaction|Side-Effect
Interventions: DIETARY_SUPPLEMENT: Mulberry juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetic Study of Paracetamol UNIFLASH (125 MG/1.25 ML)
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: paracetamol Uniflash (125 mg/ 1.25 mL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Presurgery Bortezomib for Recurrent Malignant Gliomas Followed by Postop Bortezomib & Temozolomide
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: Bortezomib|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Itacitinib in Moderate to Severe Ulcerative Colitis
Status: WITHDRAWN
Conditions: Moderate to Severe Ulcerative Colitis
Interventions: DRUG: Itacitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MAXIMA Study: A Study of Maintenance Therapy With MabThera (Rituximab) in Patients With Non-Hodgkin's Lymphoma.
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: rituximab [MabThera/Rituxan]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Ultrasound Replace Amniocentesis for Confirming Fetal Lung Maturation Among Premature Fetuses?
Status: TERMINATED
Conditions: Fetal Lung Maturity
Interventions: DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Demonstrate the Relative Bioavailability of Geneva and Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fed and Fasted Conditions
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Geneva 25 mg Clomipramine Hydrochloride Capsules Under Fasting Conditions|DRUG: Geneva 25 mg Clomipramine Hydrochloride Capsules Under Fed Conditions|DRUG: Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fed Conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HKT288 in Solid Tumors, Including Epithelial Ovarian Cancer and Renal Cell Carcinoma
Status: TERMINATED
Conditions: Epithelial Ovarian Cancer|Renal Cell Carcinoma
Interventions: DRUG: HKT288
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retention Rate And Caries Prevention Of Giomer Based Sealant With And Without Pre-Treatment With Bioactive Glass Air Abrasion In Young Adults
Status: NOT_YET_RECRUITING
Conditions: Dental Caries
Interventions: PROCEDURE: surface treatment with Bioactive Glass Air Abrasion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Drinking Clear Fluids Until Called to the Operating Room in Adult Surgical Patients
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Thirst; Due to Deprivation of Water|Aspiration
Interventions: BEHAVIORAL: Additional pre-OP-visit|BEHAVIORAL: Liberal fasting regime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial to Evaluate Pharmacokinetic Interactions and Safety Between Fimasartan and Linagliptin in Healthy Male Volunteers
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: (fimasartan or linagliptin) x 7days|DRUG: (fimasartan and linagliptin) x 7days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Curative Effect of the Length of the Jejunum Exclusion in Grstric Bypass Surgery for Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes|Obesity
Interventions: PROCEDURE: short biliarypancreatic limb|PROCEDURE: long biliarypancreatic limb
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mobile Phone Messaging To Improve Oral Hygiene Among Primary School Children in Pakistan
Status: COMPLETED
Conditions: Oral Hygiene|Dental Plaque Induced Gingivitis
Interventions: BEHAVIORAL: Mobile Phone Messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cerclage With Progesterone Versus Progesterone Only in Singleton Pregnancies
Status: RECRUITING
Conditions: Preterm Birth|Short Cervix
Interventions: PROCEDURE: Cervical cerclage|DRUG: Vaginal progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Human Factors Analysis in VR for Burn Treatment
Status: COMPLETED
Conditions: Pain|Chronic Pain
Interventions: BEHAVIORAL: Virtual Reality based distraction|BEHAVIORAL: VR with flat projection display|BEHAVIORAL: non-interactive video with head display|BEHAVIORAL: non-interactive video with with flat projection display
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Therapy for Scabies With Two Differently Concentrated Permethrin Creams
Status: NOT_YET_RECRUITING
Conditions: Scabies
Interventions: DRUG: 5% Permethrin Creme|DRUG: 10% Permethrin Creme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholesterolemia (MK-0653-018)
Status: COMPLETED
Conditions: Familial Hypercholesterolemia
Interventions: DRUG: Atorvastatin|DRUG: Simvastatin|DRUG: Ezetimibe|DRUG: Placebo for Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective, Randomized, Masked, Controlled Trial To Evaluate The Safety And Effectiveness Of The TearCare® System In The Treatment Of The Signs And Symptoms Of Dry Eye Disease (SAHARA)
Status: UNKNOWN
Conditions: Dry Eye|Meibomian Gland Dysfunction
Interventions: DEVICE: TearCare System|DRUG: Restasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of Biotelemetry in Amyotrophic Lateral Sclerosis
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: Faros Sensor (FS) and LifeInsight Hub|DEVICE: Fast Fix electrode patch|PROCEDURE: Quantitative Measure of Speech (Core Phase Only)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparing Superficial vs. Deep Local Anesthetic Infiltration to Improve Patient Experience During Carpal Tunnel Release
Status: COMPLETED
Conditions: Carpal Tunnel|Carpal Tunnel Syndrome
Interventions: PROCEDURE: Superficial local anesthetic infiltration|PROCEDURE: Deep local anesthetic infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Post-surgical Cystoid Macular Edema With Topical Steroids Trial (TEMPEST-1)
Status: COMPLETED
Conditions: Post-surgical Cystoid Macular Edema (PSCME)
Interventions: DRUG: PredA + Kelac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase IV Study to Compare Efficacy and Safety of Plavix 75mg With Astrix 100mg and Closone
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Closone|DRUG: Plavix with Astrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin Pharmacokinetics With and Without Ca2+/MG2+ Infusion in Colorectal Cancer Patients
Status: UNKNOWN
Conditions: Neoplasms, Colorectal|Colorectal Cancer|Colorectal Carcinoma
Interventions: OTHER: (supplement) Calcium and Magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioavailability of Dienogest and Ethinyl Estradiol Tablets 2.0 mg/0.03 mg With Regards to Reference Product
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: Dienogest 2.0 mg and Ethinyl estradiol 0.03 mg Test Drug|DRUG: Dienogest 2.0 mg and Ethinyl estradiol 0.03 mg Reference Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Sertindole on Sensory Gating and Cognition in Schizophrenic Patients
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Sertindole|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP)
Status: RECRUITING
Conditions: Xeroderma Pigmentosum
Interventions: DRUG: Afamelanotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: YL211
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Stage IV Melanoma|Recurrent Melanoma
Interventions: DRUG: allogeneic lymphocytes|DRUG: anti-thymocyte globulin|DRUG: cyclophosphamide|DRUG: fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: VS-6766+Abema+Fulv in Met HR+/HER- BC
Status: RECRUITING
Conditions: Breast Cancer|Hormone Receptor-positive Breast Cancer|Hormone Receptor Positive HER-2 Negative Breast Cancer
Interventions: DRUG: VS-6766|DRUG: Abemaciclib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment
Status: RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: BEHAVIORAL: Keto Diet|BEHAVIORAL: Standard Anti-Cancer Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Chat Messaging for Smoking Relapse Prevention
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Standard smoking cessation treatment|BEHAVIORAL: Personalised chat messaging|BEHAVIORAL: SMS text messaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days.
Status: COMPLETED
Conditions: Maxillary Sinusitis
Interventions: DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of Cyclophosphamide in HIV-Infected Subjects on HAART Receiving SB-728-T
Status: COMPLETED
Conditions: HIV
Interventions: GENETIC: SB-728-T|GENETIC: SB-728-T|GENETIC: SB-728-T|GENETIC: SB-728-T|GENETIC: SB-728-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Relative Bioavailability of Three SPN-817 Treatments (A, B and C) in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: SPN-817, Treatment B|DRUG: SPN-817, Treatment C|DRUG: BIS-001, Treatment A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: VX-548|DRUG: HB/APAP|DRUG: Placebo (matched to VX-548)|DRUG: Placebo (matched to HB/APAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TJ301 IV in Participants With Active Ulcerative Colitis
Status: COMPLETED
Conditions: Active Ulcerative Colitis
Interventions: DRUG: TJ301 300mg|DRUG: TJ301 600mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation for Prevention of Radiodermatitis in Women With Breast Cancer Undergoing Adjuvant Radiotherapy
Status: NOT_YET_RECRUITING
Conditions: Radiodermatitis
Interventions: DEVICE: Photobiomodulation through LED board
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: S-1 Versus Capecitabine in the First Line Treatment of MCC Patients.
Status: COMPLETED
Conditions: Colorectal Cancer|Metastases
Interventions: DRUG: Capecitabine|DRUG: Teysuno|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Laughter Therapy on hemodıalysıs patıents
Status: ACTIVE_NOT_RECRUITING
Conditions: Laughter Therapy|Depression, Anxiety|Hemodialysis|Life Quality
Interventions: OTHER: Laughter therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Use Electroencephalogram to Study Neural Dynamics of Fear Conditioning and Avoidance Learning Circuit in Humans
Status: RECRUITING
Conditions: Neural Dynamics of the Acquisition and Retention of Fear Learning and Active Avoidance Learning
Interventions: BEHAVIORAL: Conditioning and active avoidance paradigm (CAAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to See If Taking One or Two Extra Drugs Can Lower HIV Levels in Patients Who Have Failed Their Anti-HIV Drug Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Abacavir sulfate|DRUG: Amprenavir
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of Accuracy and Functional Outcome Between Robotic and Gyroscopic Assisted Surgery in Primary TKA
Status: COMPLETED
Conditions: Knee Arthropathy
Interventions: DEVICE: ROSA robotic assist TKA|PROCEDURE: iassist TKA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Marin Protein Hydrolysate and Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: MPH_active|DIETARY_SUPPLEMENT: MPH_placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Single Meal Effects of Trout on Cardiovascular Risk Markers and Plasma Proteome
Status: UNKNOWN
Conditions: Cardiovascular Diseases|Metabolic Syndrome
Interventions: BEHAVIORAL: Intake of rainbow trout from different feeding conditions versus a control poultry meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: RCT: The Effect of Held Position During Kangaroo Care on Physiological Parameters of Premature Infants
Status: COMPLETED
Conditions: Extreme Prematurity|Extremely Low Birth Weight|Very Low Birth Weight Infant|Premature Birth
Interventions: OTHER: Held Position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bortezomib, Doxorubicin Hydrochloride Liposome, and Rituximab in Treating Patients With Diffuse Large B-Cell Lymphoma That Has Relapsed or Not Responded to Treatment
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: bortezomib|DRUG: pegylated liposomal doxorubicin hydrochloride|GENETIC: gene expression analysis|GENETIC: polymerase chain reaction|GENETIC: polymorphism analysis|GENETIC: proteomic profiling|OTHER: flow cytometry|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eccentric Exercise or Radiofrequent Microtenotomy as Treatment of Lateral Epicondylalgia
Status: UNKNOWN
Conditions: Tennis Elbow
Interventions: PROCEDURE: Radiofrequency microtenotomy|OTHER: Eccentric exercise|DEVICE: Arthrocare Topaz MicroDebrider
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The HEALiX: Comparing the Efficacy of the HEALiX Device With Wrist Restraints in a Critical Care Setting
Status: NOT_YET_RECRUITING
Conditions: Safety Issues|Device Dislodgement|Device Intolerance|Device Ineffective
Interventions: DEVICE: HEALiX is an alternative restraint patient safety device|DEVICE: soft wrist restraints
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combined Effects of Visceral Manipulation and Noble Technique on Post-partum Females With Diastasis Recti
Status: NOT_YET_RECRUITING
Conditions: Diastasis Recti
Interventions: OTHER: visceral manipulation and noble technique|OTHER: noble technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TACE, Sorafenib and PD-1 Monoclonal Antibody in the Treatment of HCC
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Liver Neoplasms|Digestive System Neoplasms|Sorafenib|Molecular Mechanisms of Pharmacological Action|Liver Diseases|Antineoplastic Agents|Protein Kinase Inhibitors
Interventions: COMBINATION_PRODUCT: TACE combined with sorafenib and PD-1 mAb
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of the Use of Sodium Pyruvate Bronchodilation in Asthmatics
Status: TERMINATED
Conditions: Moderate Asthma
Interventions: DRUG: sodium pyruvate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Volunteers to Assess the Effect of Different Types of Food on a Single-dose of JNJ-64417184 Administered as Tablets
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-64417184
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Neo-adjuvant Combination Scheme of Ipilimumab and Nivolumab
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Melanoma Stage III
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab|PROCEDURE: Surgery|PROCEDURE: Blood for PBMCs|PROCEDURE: Biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: BIOLOGICAL: URLC10, VEGFR1 and VEGFR2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ferriprox™ (Deferiprone) Oral Solution in Iron Overloaded Pediatric Patients
Status: COMPLETED
Conditions: Iron Overload
Interventions: DRUG: Deferiprone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/2 Dose Escalation and Efficacy Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies
Status: COMPLETED
Conditions: Hematological Malignancy
Interventions: DRUG: Isatuximab SAR650984|DRUG: Dexamethasone|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Use of Zenapax (Daclizumab) and CellCept (Mycophenolate Mofetil) to Improve Kidney Function in Kidney Transplant Patients
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Corticosteroids|DRUG: Neoral|DRUG: Neoral|DRUG: Zenapax|DRUG: mycophenolate mofetil [CellCept]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Group A, C, Y & W-135 Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine for Meningitis
Status: COMPLETED
Conditions: Meningococcal Meningitis|Meningococcal Infections
Interventions: BIOLOGICAL: meningococcal meningitis conjugate vaccine, quadrivalent|BIOLOGICAL: meningococcal meningitis conjugate vaccine, quadrivalent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sleep and Circadian Rhythm Study in Head and Neck Cancer Patients
Status: WITHDRAWN
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|OTHER: Counseling|OTHER: Educational Intervention|OTHER: Electronic Health Record Review|OTHER: Medical Device Usage and Evaluation|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy
Status: COMPLETED
Conditions: Cardiomyopathy, Hypertrophic
Interventions: DEVICE: Active pacing|DEVICE: Back-up pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Neoplasms|Squamous Cell Carcinoma
Interventions: DRUG: metformin up to 2500mg/d|DRUG: paclitaxel 175mg/m² q21d|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RIGHTWHEY - Responders In Gut HealTh Markers Using Fermented WHEY
Status: TERMINATED
Conditions: Health, Subjective|Healthy|Microbial Colonization
Interventions: DIETARY_SUPPLEMENT: Fermented whey concentrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Dynamic Elastomeric Fabric Orthosis (DEFO) on Sitting Balance and Gross Manuel Dexterity in Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Postural; Defect
Interventions: DEVICE: SPIO|OTHER: conventional exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Reality for Hemiparetic Arm in the Stroke Patients
Status: UNKNOWN
Conditions: Stroke|Paresis|Mirror Movement
Interventions: DEVICE: Enhanced reality|OTHER: No Enhanced reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Radiotherapy for High-risk UTUC
Status: NOT_YET_RECRUITING
Conditions: Urothelial Carcinoma of the Renal Pelvis and Ureter
Interventions: RADIATION: Neoadjuvant radiotherapy|COMBINATION_PRODUCT: Neoadjuvant drug therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Platelet Rich Plasma on Non-scarring Alopecia
Status: COMPLETED
Conditions: Androgenetic Alopecia|Alopecia
Interventions: DEVICE: Platelet Rich Plasma|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amino Acid Balance During Physical Inactivity
Status: COMPLETED
Conditions: Assessing Muscle Amino Acid Balance
Interventions: OTHER: High-fat overfeeding|OTHER: Forearm immobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: NRX101 Glx Biomarker Validation Study
Status: COMPLETED
Conditions: Bipolar Depression|Suicidal Ideation
Interventions: DRUG: NRX-101|DRUG: Lurasidone HCl|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Relative Bioavailability And Food Effect of a Tablet Formulation of GDC-0276 in Healthy Participants
Status: WITHDRAWN
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0276 capsule|DRUG: GDC-0276 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Efficacy and Safety of ASP5094 in Patients With Rheumatoid Arthritis on Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: ASP5094|DRUG: Placebo|OTHER: Methotrexate therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)
Status: COMPLETED
Conditions: IgA Glomerulonephritis
Interventions: DRUG: methylprednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Gabapentin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Preoperative Enema in the Prevention of Catheter Dysfunction in Peritoneal Dialysis
Status: NOT_YET_RECRUITING
Conditions: Peritoneal Dialysis Access Failure
Interventions: PROCEDURE: enema
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC110114 Tablets in HCV-infected Subjects
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: HEC110114 Tablet|DRUG: Sofosbuvir Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Bilateral TAP Block Versus Curare in Muscle Relaxation of the Abdominal Wall During Laparoscopic Digestive Surgery: Prospective Randomized Study
Status: COMPLETED
Conditions: The Main of This Study is to Compare the Nerve Block of the Muscles of the Abdominal Wall Between the Bilateral TAP Block and Curare
Interventions: DRUG: Transversus Abdominis Plane|DRUG: Curare
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Near-Threshold Perception During Anesthetic Sedation
Status: RECRUITING
Conditions: Propofol|Anesthesia|fMRI
Interventions: COMBINATION_PRODUCT: Functional Magnetic Resonance Imaging (fMRI) with propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: S0338, Imatinib Mesylate and Capecitabine in Treating Women With Progressive Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: Imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T Cell Vaccination in Patients With Progressive Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: multiple (4 autologous subcutaneous T cell vaccinations with T cell lines reactive to nine myelin peptides)|BIOLOGICAL: T cell vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: XP13512 vs. Placebo in Patients With Restless Legs Syndrome.
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: XP13512 600MG|DRUG: XP13512 1200MG|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain
Status: RECRUITING
Conditions: Diabetic Neuropathies|Chronic Pain
Interventions: DEVICE: Active Comparator: Active tDCS + Active TUS|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ITIC (Imiquimod Therapy in Cervical Intraepithelial Neoplasia)-Trial
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: DRUG: Topical imiquimod therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Anlotinib With Chemoradiation for Patients With Locally Advanced Nasopharyngeal Carcinoma
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Anlotinib hydrochloride|DRUG: induction chemotherapy|RADIATION: concurrent chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Age of Exposure and Immunity to Malaria in Infants
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Sulfadoxine-pyrimethamine (SP) + Artesunate (AS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)
Status: RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Malignant Solid Neoplasm|Recurrent Ependymoma|Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Hepatoblastoma|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Glioma|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Primary Central Nervous System Neoplasm|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Refractory Ependymoma|Refractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Refractory Hepatoblastoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Glioma|Refractory Malignant Solid Neoplasm|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Primary Central Nervous System Neoplasm|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma|Wilms Tumor
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: Ensartinib|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|OTHER: Pharmacological Study|PROCEDURE: Positron Emission Tomography|PROCEDURE: Radionuclide Imaging|PROCEDURE: X-Ray Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, Plasma Drug Levels, and Cognitive Response Following Multiple Doses of a Drug in Healthy Elderly Participants.
Status: COMPLETED
Conditions: Healthy|Elderly
Interventions: DRUG: PF-04447943|DRUG: PF-04447943|DRUG: PF-04447943|DRUG: PF-04447943|DRUG: PF-04447943
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Antibiotic Prophylaxis in Metabolic Bariatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Antibiotic Reaction|Wound Infection Superficial|Wound Infection Deep|Bariatric Surgery Candidate|Complication,Postoperative
Interventions: DRUG: 2000 mg of Cefazolin|DRUG: 500 mg of Metronidazole IV|DRUG: NACL 0.9% 100 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Randomized Comparison of Warfarin Dosing Quality Between the Hamilton Nomogram and a Commercial Computer System
Status: COMPLETED
Conditions: Patients at Risk for Thrombosis
Interventions: DEVICE: DAWN AC|DEVICE: Hamilton Nomogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of SB-742457 or Donepezil Versus Placebo in Subjects With Mild-to-moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: SB-742457|DRUG: Donepezil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Heart Decompensation
Interventions: DRUG: Nesiritide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Derived Organoid-guided Personalized Treatment Versus Treatment of Physician's Choice in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Refractory Breast Carcinoma
Interventions: OTHER: Organoid-guided personalized treatment|DRUG: Gemcitabine|DRUG: Capecitabine|DRUG: Vinorelbine|DRUG: Eribulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Role of Plavix in Hemorrhagic and Ischemic Complications of Catheterization.
Status: TERMINATED
Conditions: Coronary Artery Disease|Myocardial Ischemia|Bleeding
Interventions: DRUG: clopidogrel 600 mg|DEVICE: arterial access sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Asymmetric And Standard Split-Dose Regimen For Bowel Preparation
Status: COMPLETED
Conditions: Polyps|Colon Preparation
Interventions: DRUG: PEG-4000 added with citrates and simethicone (PEG-CS) plus Bisacodyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Stem Cell Transplantation for Hematologic Malignancies Using Clofarabine and Busulfan Regimen
Status: COMPLETED
Conditions: Leukemia|Hodgkin Lymphoma|Non-Hodgkin Lymphoma|Multiple Myeloma|Myelodysplastic Syndrome
Interventions: DRUG: Clofarabine/Busulfan x 4|PROCEDURE: Peripheral blood stem cell transplant|RADIATION: Total Lymphoid Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ibuprofen (IBU) 250mg/APAP 500mg In The Treatment Of Post-Surgical Dental Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: FDC IBU/APAP 250 mg/500 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of Immunoglobulin (Ig) Treatment in COPD Outpatients With Frequent Exacerbations: Pilot Study 1
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Intravenous immunoglobulin|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Metronomic Oral Chemotherapy With Cyclophosphamide, Capecitabine and Vinorelbine in Metastatic Breast Cancer Patients
Status: RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: Vinorelbine|DRUG: Capecitabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma
Status: TERMINATED
Conditions: Malignant Glioma (WHO Grade III or IV)
Interventions: DRUG: CTO|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab, Anlotinib Hydrochloride and Platinum-Containing Dual-Agent Chemotherapy in NSCLC
Status: UNKNOWN
Conditions: Metastatic NSCLC|Recurrent NSCLC|Advanced Non-Small Cell Squamous Lung Cancer
Interventions: DRUG: Sintilimab + Anlotinib + Pemetrexed + Cisplatin or Carboplatin|DRUG: Sintilimab + Anlotinib + Albumin Paclitaxel + Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of Myosteatosis and Creatinine-to-cystatin C Ratio in Patients With Pancreatic Ductal Adenocarcinoma
Status: RECRUITING
Conditions: Skeletal Muscle Radiodensity|Myosteatosis|Scr/CysC Ratio|Pancreatic Ductal Adenocarcinoma
Interventions: OTHER
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Effect of Enantone LP 11.25 mg (Leuprorelin) on the Histological Progression of Indolent Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprorelin|DRUG: Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capsaicin for Post-stroke Dysphagia
Status: RECRUITING
Conditions: Dysphagia, Late Effect of Stroke
Interventions: DRUG: Capsaicin 1% oral solution|DRUG: InOrpha Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Assess Efficacy and Safety of STALORAL® 300 IR Sublingual Immunotherapy (SLIT) in Asthmatic Patients Allergic to House-dust Mites
Status: COMPLETED
Conditions: Allergy
Interventions: DRUG: Staloral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SYN120 Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE)
Status: COMPLETED
Conditions: Parkinson's Disease Dementia (PDD)
Interventions: DRUG: SYN120|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK119 (Anti-CD73) in Combination With AK104 in Subjects With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: BIOLOGICAL: AK119|BIOLOGICAL: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining the Impact of Using Two Dialysers in Parallel on Dialysis Adequacy in Hemodialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: PROCEDURE: Single dialyzer|PROCEDURE: Two dialyzers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer
Status: RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: RADIATION: Neoadjuvant radiotherapy (arm A)|DRUG: Carboplatin, paclitaxel|PROCEDURE: Esophagectomy|RADIATION: Neoadjuvant radiotherapy (arm B)|DRUG: Carboplatin, paclitaxel|DRUG: Cisplatin, paclitaxel|DRUG: Oxaliplatin, calcium folinate, 5-fluorouracil|PROCEDURE: Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.
Status: COMPLETED
Conditions: Alzheimer Disease|Glucose Metabolism
Interventions: DIETARY_SUPPLEMENT: low carb diet|DIETARY_SUPPLEMENT: Regular diet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION