pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Phase I Study of Continuous Infusion Immunotoxin IgG-RFB4-SMPT-dgA in Refractory CD22 Positive B-Cell Lymphoma
Status: COMPLETED
Conditions: B Cell Lymphoma
Interventions: DRUG: IgG-RFB4-SMPT-dgA
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: the Safety and Effectiveness of Precise rTMS Based on Neuroimaging in the Treatment of Adolescent Depression With Anhedoniadepression With Anhedonia
Status: RECRUITING
Conditions: Major Depressive Disorder|Repetitive Transcranial Magnetic Stimulation
Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain
Status: COMPLETED
Conditions: Osteoarthritis|Rheumatoid Arthritis|Lower Back Pain|Joint Pain|Muscle Pain
Interventions: DRUG: Buprenorphine transdermal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Antibacterial Effect of a Toothpaste Containing Zinc Lactate
Status: NOT_YET_RECRUITING
Conditions: Oral Bacterial Infection
Interventions: COMBINATION_PRODUCT: Zinc toothpaste|COMBINATION_PRODUCT: Fluoride Toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Brentuximab Vedotin, Rituximab, and Dose Attenuated CHP in Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: Brentuximab vedotin|DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Tolerability of Nitric Oxide Impregnated Urinary Catheters
Status: COMPLETED
Conditions: Urinary Tract Infection|Bacteriuria
Interventions: DEVICE: Nitric Oxide impregnated catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Maintain Respiratory Muscle Function and Reduce Pneumonia Risk in Cancer Patients
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: 1,25 (OH)2 D3|OTHER: Inspiratory isometric resistance training|DRUG: Oral Placebo|OTHER: Sham Inspiratory Isometric Resistance Training|DEVICE: Threshold Inspiratory Muscle Trainer (IMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Examine the Glycemic Response of Corn and Soy Tortillas in Healthy Individuals
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Oral Glucose Solution 296 mls|OTHER: Corn Tortilla|OTHER: Low Soy Flour Corn Tortilla|OTHER: Moderate Soy Flour Corn Tortilla|OTHER: High Soy Flour Corn Tortilla
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Leading Well-being and the Psychosocial Working Environment - A Cluster-randomized Waitlist Controlled Trial
Status: UNKNOWN
Conditions: Stress|Well-being|Burn Out
Interventions: BEHAVIORAL: Training leaders in leading well-being and the psychosocial working environment|BEHAVIORAL: The offer of a webinar and written material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Whether Opioids Are Factor That Induced POD?
Status: COMPLETED
Conditions: Postoperative Delirium
Interventions: DRUG: Sufentanil Citrate|DRUG: Ropivacaine 0.75% Injectable Solution|PROCEDURE: Epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Two-piece Zirconia Implants With Two Various Platforms
Status: RECRUITING
Conditions: Edentulous Alveolar Ridge
Interventions: DEVICE: Zirconia dental implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CARotid Mri of Atherosclerosis
Status: COMPLETED
Conditions: Carotid Stenosis|Carotid Artery Plaque|Carotid Atherosclerosis
Interventions: OTHER: Optimization of cardiovascular risk management
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Kangaroo Care and Swaddling Methods on Pain Level and Crying Time During Heel Blood Collection
Status: RECRUITING
Conditions: Pain, Acute|Newborns|Crying
Interventions: BEHAVIORAL: Kangaroo Care|BEHAVIORAL: Swaddling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Clinical Performance of 3D Printed Polyether Ether Ketone (PEEK) Inlays
Status: UNKNOWN
Conditions: Occlusal Caries
Interventions: OTHER: Poly ether ether ketone (PEEK)|OTHER: CADCAM Poly ether ether ketone (PEEK)|OTHER: indirect resin composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity
Status: UNKNOWN
Conditions: Aortic Stenosis|Cardiac Death
Interventions: OTHER: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TAF/FTC for Pre-exposure Prophylaxis of COVID-19 in Healthcare Workers (CoviPrep Study)
Status: UNKNOWN
Conditions: Healthcare Workers|COVID-19|SARS-CoV 2
Interventions: DRUG: Emtricitabine/Tenofovir Alafenamide 200 MG-25 MG Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Benepali|DRUG: Sulfasalazine|DRUG: Methotrexate|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth
Status: COMPLETED
Conditions: Hypoxic Ischaemic Encephalopathy
Interventions: DRUG: xenon gas|DEVICE: Whole body cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Biologic Therapy for Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Allergen Immunotherapy Extract|DRUG: Allergen Immunotherapy Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First Time in Man Trial for Friulimicin B
Status: TERMINATED
Conditions: Community Acquired Pneumonia|Staphylococcal Skin Infections
Interventions: DRUG: Friulimicin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Preference-based Intervention for Increasing Colorectal Cancer Screening
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: BEHAVIORAL: Standard Information|BEHAVIORAL: Preference-tailored Information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: ALPPS (Liver Partition and Portal Vein Ligation) for Two-stage Hepatectomy for Colorectal Liver Metastasis
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: PROCEDURE: two stage hepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis
Status: COMPLETED
Conditions: Lupus Nephritis
Interventions: PROCEDURE: Autologous hematopoietic stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Carrageenan-Elimination Diet on Ulcerative Colitis Disease Activity
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: carrageenan|OTHER: dietary intervention with no-carrageenan diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery
Status: COMPLETED
Conditions: Colon Cancer|Minimal Residual Disease
Interventions: OTHER: Epidural analgesia|DRUG: Piritramide|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-image Guided Versus Doppler Guided Versus Palpation Technique for Arterial Cannulation in Adults
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Ultrasound|PROCEDURE: Doppler|PROCEDURE: Palpation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Efficacy and Safety of Tacrolimus Capsules in Patient With Myasthenia Gravis
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: DRUG: Tacrolimus capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced/Metastatic Tumors
Interventions: DRUG: Atezolizumab|DRUG: Tiragolumab|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Etoposide|DRUG: Capecitabine|DRUG: Bevacizumab|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of R-EPOCH and R-CHOP Regimen for Patients With AIDS Associated CD20+ Diffuse Large B Lymphoma
Status: UNKNOWN
Conditions: To Evaluate the Efficacy and Safety of R-EPOCH and R-CHOP Regimen for Patients With AIDS Associated CD20+ Diffuse Large B Lymphoma
Interventions: DRUG: R-EPOCH|DRUG: R-CHOP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LY2157299 Monohydrate (LY2157299) and Radiotherapy in Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: RADIATION: Radiation therapy|DRUG: Study Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Prognostic Predictive Models of Mortality of Decompensated Cirrhotic Patients Waiting for Liver Transplantation
Status: UNKNOWN
Conditions: Decompensated Cirrhosis|Liver Transplantation
Interventions: OTHER: SuperMELD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Relationship Between Diabetes and Cognitive Impairment Based on Olfactory Function Assessment and Functional MRI
Status: COMPLETED
Conditions: Diabetes Mellitus|Cognitive Impairment|Obesity
Interventions: BEHAVIORAL: Cognitive assessment|OTHER: functional magnetic resonance imaging|OTHER: olfactory function measurement|PROCEDURE: bariatric surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PCBH With the Addition of Self-help CBT
Status: COMPLETED
Conditions: Depression, Anxiety|Quality of Life|Psychological Distress|Activities, Daily Living|Insomnia|Stress
Interventions: BEHAVIORAL: Brief interventions|BEHAVIORAL: Guided self-help CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Placebo-controlled, Double-blind Study of 2LHERP® in Orofacial Herpes Infections.
Status: RECRUITING
Conditions: Herpes Simplex
Interventions: DRUG: 2LHERP®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced Solid Tumor|Metastatic Tumor|Colorectal Adenocarcinoma
Interventions: DRUG: TST003
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vascular Effects of Triglyceride-rich Lipoproteins
Status: COMPLETED
Conditions: Postprandial Period|Lipemia|Vasodilation|Vascular Resistance|Nitric Oxide
Interventions: DIETARY_SUPPLEMENT: High-fat meals varying in their fatty acid composition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: LY2510924, Idarubicin and Cytarabine in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: LY2510924|DRUG: Idarubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections
Status: COMPLETED
Conditions: Necator Americanus Infection
Interventions: DRUG: Mebendazole polymorph A and C 500 mg|DRUG: Mebendazole polymorph C|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: tDCS Stimulation to Treat Patients With Severe and Resistant Obsessive Compulsive Disorder-Pilot Study
Status: COMPLETED
Conditions: Obsessive-compulsive Disorders and Symptoms
Interventions: OTHER: bifocal stimulation with tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Knee Osteoarthritis|Total Knee Arthroplasty (TKA)
Interventions: OTHER: Pain Scale/Medication Log
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Objective Evaluation of the Effect of Oculoplastic Operations Using the Vectra M 3D Imaging System
Status: RECRUITING
Conditions: Eyelid Ptoses|Ectropion Eyelids|Entropion;Eye
Interventions: OTHER: Vectra M3 imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nalbuphine Versus Dexmedetomidine for Prevention of Emergence Agitation in Pediatrics
Status: UNKNOWN
Conditions: Agitation
Interventions: DRUG: Nalbuphine|DRUG: Dexmedetomidine|DRUG: normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Low Cost Prostheses to Improve Upper Extremity Function in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Prosthesis User
Interventions: OTHER: Occupational Therapy Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Influence of Varenicline on the Antiplatelet Action of Clopidogrel
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Varenicline|BEHAVIORAL: Counseling and psychosocial support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hormone Replacement Therapy and the Risk of Breast Cancer Recurrence in Women With Previous Early Stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Menopausal Symptoms
Interventions: BIOLOGICAL: therapeutic estradiol|DRUG: norethindrone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of the SurgiStim3 Electrical Stimulation Device in Persons Undergoing Anterior Cruciate Ligament Repair
Status: TERMINATED
Conditions: Anterior Cruciate Ligament
Interventions: DEVICE: SurgiStim3|DEVICE: SurgiStim3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 80mg Osimertinib in Patients With Non-small Cell Lung Cancer(NSCLC)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: 80mg Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: After Hip Fracture Nailing, Compare Early Weight Bearing as Tolerated (WBAT) Group With Weight Bearing Restriction(WBR)
Status: RECRUITING
Conditions: Bony Weight Bearing Disorder
Interventions: BEHAVIORAL: Early-Weight bearing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Studying Corneal Epithelial Stability Following Limbal Stem Cell Transplantation in Cases of Limbal Stem Cell Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Stem Cell Transplantation
Interventions: PROCEDURE: conjunctival limbal autologous transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Aerobic Training on Sleep Quality and Aerobic Fitness in Male Patients With Pulmonary Artery Hypertension
Status: COMPLETED
Conditions: Pulmonary Artery Hypertension
Interventions: OTHER: Moderate intensity aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Actifuse ABX Versus INFUSE in Posterolateral Instrumented Lumbar Fusion
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: PROCEDURE: Actifuse ABX|PROCEDURE: INFUSE, plus Mastergraft granules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia
Status: COMPLETED
Conditions: Hemophilia A
Interventions: BIOLOGICAL: PF-05280602|BIOLOGICAL: PF-05280602|BIOLOGICAL: PF-05280602|BIOLOGICAL: PF-05280602|BIOLOGICAL: PF-05280602
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Retinal Vessel Leakage in Cerebral Small Vessel Disease
Status: NOT_YET_RECRUITING
Conditions: Cerebral Small Vessel Diseases|Lacunar Stroke|Vascular Dementia
Interventions: DIAGNOSTIC_TEST: Fundus fluorescein angiography, with ultrawide field retinal imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intrathecal Clonidine Addiction for Combined Spinal Epidural Analgesia During Labor
Status: UNKNOWN
Conditions: Labor Pain
Interventions: DRUG: Clonidine|DRUG: Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Combination of MK-3475 and Sterotactic Body Radiotherapy in Patients With Metastatic Melanoma or NSCLC
Status: COMPLETED
Conditions: Melanoma|Lung Cancer
Interventions: DRUG: MK-3475|RADIATION: Stereotactic Body Radiation Therapy (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Surgery After Neoadjuvant Chemotherapy for Advanced Ovarian Cancer
Status: RECRUITING
Conditions: Ovarian Epithelial Cancer
Interventions: PROCEDURE: Delayed interval cytoreductive surgery (DICS)|PROCEDURE: Early interval cytoreductive surgery (EICS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect of Lumbar Traction, Spinal Manipulation, and Surgery in the Treatment of Lumbar Disc Herniation
Status: TERMINATED
Conditions: Lumbar Disc Herniation|Lumbar Traction|Spinal Manipulation|Lumbar Surgery
Interventions: DEVICE: lumbar traction|PROCEDURE: spinal manipulation|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Efficacy of BACOPP-21 for Patients > 60 Years With Intermediate or Advanced Hodgkins Lymphoma
Status: COMPLETED
Conditions: Hodgkin´s Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Adramycin|DRUG: Procarbacine|DRUG: Prednisone|DRUG: Vincristine|DRUG: Bleomycin|DRUG: Erythropoietin beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2
Status: UNKNOWN
Conditions: Mitral Valve Prolapse
Interventions: PROCEDURE: Mitral repair with leaflet preservation|PROCEDURE: Mitral repair with leaflet resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Information Leaflet on the Anesthesia Knowledge and Anxiety Levels of Children and Parents
Status: UNKNOWN
Conditions: Anxiety|Preoperative Anxiety|Pediatric Anesthesia
Interventions: OTHER: information leaflet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess Safety, Tolerability and Reactogenicity of Vaccine "UniFluVec" After Two Intranasal Administrations in Healthy Volunteers
Status: COMPLETED
Conditions: Influenza A
Interventions: BIOLOGICAL: UniFluVec|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Two Different Treatment Protocols on Shoulder Function, Quality of Life, and Ultrasound Parameters in Patients With Frozen Shoulder
Status: NOT_YET_RECRUITING
Conditions: Frozen Shoulder|Shoulder Capsulitis|Shoulder Pain
Interventions: OTHER: Intra-articular corticosteroid injection|OTHER: Ultrasound Guided Hydrodilatation with corticosteroid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiplex Testing for Breast Cancer Susceptibility: A Pilot Study of Subject Preferences for Information and Responses After Testing
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Pre-test Assessment|BEHAVIORAL: Pre test Counseling|OTHER: Blood draw|BEHAVIORAL: Post-test counseling, and post-test assessment|BEHAVIORAL: Follow-up assessments (6 and 12 months)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective Randomized Controlled Clinical Trial of Standard Versus Goal-Directed Perioperative Fluid Management (GDT) for Patients Undergoing Radical Cystectomy
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: OTHER: standard fluid management|OTHER: fluid management guided by the EV1000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Postoperative Adjuvant Chemotherapy for Upper Urinary Urothelial Carcinoma With Lymphovascular Invasion
Status: UNKNOWN
Conditions: Chemotherapy Effect
Interventions: DRUG: Gemcitabine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal Stimulation as a Treatment of Postoperative Ileus Following Extensive Surgery
Status: RECRUITING
Conditions: Postoperative Ileus|Bowel Paralysis
Interventions: DEVICE: Gastric electric pacemaker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
Status: COMPLETED
Conditions: Drug-withdrawal.|Drug Abuse|Drug-induced Depressive State|AOD Craving|AODR Depressive State
Interventions: DRUG: Mirtazapine (REMERON, Schering-Plough-Organon)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Equivalence of Boosted Atazanavir Based Regimens and Currently Effective HAART Regimens
Status: COMPLETED
Conditions: Pediatric HIV|HIV Infections
Interventions: DRUG: Boosted Atazanavir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Infection in Children With Chronic Idiopathic Thrombocytopenic Purpura
Status: COMPLETED
Conditions: Chronic Idiopathic Thrombocytopenic Purpura|Helicobacter Pylori Infection
Interventions: DRUG: lansoprazole, clarithromycin, amoxycillin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain After Medical Abortion Under Local Anesthesia : Comparison of Several Analgesic Regimen
Status: COMPLETED
Conditions: Abortion, Induced
Interventions: DRUG: paracetamol|DRUG: ketoprofen|DRUG: ketoprofen + paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intravenous Lipids on Lung Function in Acute Respiratory Distress Syndrome (ARDS)
Status: TERMINATED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: ClinOleic 20%|DRUG: Intralipid 20%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: U-LABA/ICS Effects on Exercise Performance, Formoterol
Status: COMPLETED
Conditions: Exercise Performance
Interventions: DRUG: Symbicort|DRUG: Formoterol|DRUG: Formoterol|DRUG: Placebo|DRUG: Mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oocyte Vitrification Aided With Latrunculin A
Status: COMPLETED
Conditions: Infertility
Interventions: OTHER: Latrunculin A supplemented vitrification medium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Optimization of Fetal Biometry With 3D Ultrasound and Image Recognition
Status: COMPLETED
Conditions: Pregnancy Related
Interventions: DEVICE: 3D volume acquisitions|DEVICE: 2D standard measurements and 3D volumes acquisitions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: MRI Assessment of Cartilage Damage in Tibial Nailing
Status: UNKNOWN
Conditions: Tibial Fractures
Interventions: OTHER: Surgical Approach - Infra-patella nailing|OTHER: Surgical Approach - Supra-patella nailing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of UCAD for Diagnosing Urothelial Carcinoma.
Status: UNKNOWN
Conditions: Urothelial Carcinoma|Diagnoses Disease|Chromosomal Abnormality|Urine Marking
Interventions: DIAGNOSTIC_TEST: Low-coverage whole-genome sequencing of urine exfoliated cells
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Role of Circadian and Homeostatic Systems in the Regulation of Wakefulness in Adult Patients With Attention Deficit Disorder With or Without Hyperactivity
Status: COMPLETED
Conditions: Attention-Deficit/Hyperactivity Disorder
Interventions: OTHER: Neuropsychological tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Laparoscopic Assisted Dismembered Pyeloplasty Versus Open Pyeloplasty in (UPJO) With Poorly Function Kidney in Pediatrics
Status: COMPLETED
Conditions: Uretro-pelvic Junction Obstruction|Poorly Function Kidney
Interventions: PROCEDURE: Dismembered Pyeloplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Ad-RTS-hIL-12 With Veledimex in Subjects With Glioblastoma or Malignant Glioma
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Anaplastic Oligoastrocytoma
Interventions: BIOLOGICAL: Ad-RTS-hIL-12|DRUG: veledimex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Neurodynamic Mobilization on Median Nerve Conduction Velocity in Carpal Tunnel Syndrome
Status: NOT_YET_RECRUITING
Conditions: Median Nerve Entrapment|Carpal Tunnel Syndrome
Interventions: OTHER: conventional Treatment|OTHER: Neurodynamic mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Trial for Pixantrone in Combination With Rituximab in Indolent Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Lymphoma, Follicular|Lymphoma, Mixed-Cell, Follicular|Lymphoma, Small Cleaved-Cell, Follicular|Lymphoma, Low-Grade
Interventions: DRUG: rituximab|DRUG: Pixantrone (BBR 2778)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Gluten-Free Diet and Mediterranean Diet
Status: COMPLETED
Conditions: Hashimoto Thyroiditis|Hashimoto Disease
Interventions: OTHER: mediterranean, gluten-free and mediterranean gluten-free diet intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Liposome-encapsulated Daunorubicin-Cytarabine and Venetoclax in Treating Participants With Relapsed, Refractory or Untreated Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Liposome-encapsulated Daunorubicin-Cytarabine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel (Taxotere) and Imatinib Mesylate (Gleevec) in Hormone Refractory Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Prostatic Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Imatinib Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Surgical Incision Size on Carpal Tunnel Surgery
Status: TERMINATED
Conditions: Carpal Tunnel Syndrome
Interventions: PROCEDURE: Carpal Tunnel Release Surgery|PROCEDURE: Carpal tunnel release surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients
Status: COMPLETED
Conditions: Benzodiazepine Dependence|Opioid Dependence
Interventions: DRUG: Gabapentin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors
Status: TERMINATED
Conditions: Glioma|Brain Cancer|Brain Tumor|Glioblastoma Multiforme|High Grade Glioma
Interventions: BIOLOGICAL: Dendritic Cell Vaccine|BIOLOGICAL: Tumor Lysate|OTHER: Imiquimod|PROCEDURE: Leukapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-arm, Phase II Exploratory Study of Sintilimab in Combination With Chemoradiotherapy in Elderly Patients With Locally Advanced Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Sintilimab|DRUG: S-1|DRUG: Capecitabine|RADIATION: Extraperitoneal radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors and Lymphomas
Status: RECRUITING
Conditions: Advanced Lymphoma|Advanced Malignant Solid Neoplasm|Advanced Pancreatic Carcinoma|B-Cell Non-Hodgkin Lymphoma|Metastatic Pancreatic Carcinoma|Refractory B-Cell Non-Hodgkin Lymphoma|Refractory Lymphoma|Refractory Malignant Solid Neoplasm|Refractory Pancreatic Carcinoma|Refractory T-Cell Non-Hodgkin Lymphoma|Stage II Pancreatic Cancer AJCC v8|Stage III Pancreatic Cancer AJCC v8|Stage IV Pancreatic Cancer AJCC v8|Unresectable Pancreatic Carcinoma
Interventions: DRUG: BET Bromodomain Inhibitor ZEN-3694|PROCEDURE: Core Biopsy|DRUG: Entinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sequential Immunization of Two Doses of Inactivated COVID-19 Vaccine (Omicron) in Vaccinated Population Aged 18 Years and Above
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: BIBP Omicron Inactivated COVID-19 vaccine (Vero Cell)|BIOLOGICAL: WIBP Omicron Inactivated COVID-19 vaccine (Vero Cell)|BIOLOGICAL: COVID-19 Vaccine (Vero Cell), Inactivated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of the Combination of PRP and ESWT in Lateral Epicondylitis
Status: COMPLETED
Conditions: Musculoskeletal Diseases|Elbow Tendinitis|Lateral Epicondylitis|Platelet-Rich Plasma (PRP)
Interventions: OTHER: ESWT+Exercise|PROCEDURE: PRP+ESWT+Exercise|PROCEDURE: Sham PRP+ESWT+Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects
Status: UNKNOWN
Conditions: Hypertension
Interventions: DRUG: Angiotensin 1-7|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation
Status: COMPLETED
Conditions: Critically Ill|Acute Kidney Injury|Renal Replacement Therapy|Continuous Renal Replacement Therapy|Continuous Veno-Venous Hemofiltration|Replacement Fluid|Phoxilium|Biphozyl|Anticoagulation|Regional Citrate Anticoagulation
Interventions: DRUG: CVVH with Phoxilium® in the first 48h after randomization|DRUG: CVVH with Biphozyl® in the first 48h after randomization|DRUG: CVVH with Phoxilium® in the second 48h after randomization (after previous 48h with Biphozyl®)|DRUG: CVVH with Biphozyl® in the second 48h after randomization (after previous 48h with Phoxilium®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Mobile Application for Teaching Clinical Nursing Skill at a Higher Education Institution in Chenzhou, China
Status: RECRUITING
Conditions: Nursing Education
Interventions: BEHAVIORAL: Online and offline blended teaching|BEHAVIORAL: Traditional teaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence Study of Two Strengths of Two Different Metformin Tablets Administered to Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Merck Glucophage® high dose|DRUG: BMS Glucophage® high dose|DRUG: Merck Glucophage® low dose|DRUG: BMS Glucophage® low dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality Mindfulness Meditation After ACL Reconstruction
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injury
Interventions: BEHAVIORAL: Virtual Reality Mindfulness Meditation|BEHAVIORAL: Virtual Reality Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anidulafungin in Treating Immunocompromised Children With Neutropenia
Status: COMPLETED
Conditions: Infection|Neutropenia|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: anidulafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Transcranial Magnetic Stimulation (rTMS) Accelerates the Response to Escitalopram in Major Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: DEVICE: rTMS|DEVICE: TMS|DEVICE: rTMS|DEVICE: rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infra- and Supratentorial Neuromonitoring
Status: RECRUITING
Conditions: Intracranial Pressure Increase|Posterior Fossa Lesion|Posterior Fossa Hemorrhage
Interventions: DEVICE: Multimodal neuromonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: iVAPS vs. S/T Modes as Non-invasive Weaning Strategy in COPD Patients
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: DEVICE: Extubation to NIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1)
Status: COMPLETED
Conditions: Down Syndrome|Obstructive Sleep Apnea
Interventions: BEHAVIORAL: Open-ended semi-structured interviews
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial to Compare the Efficacy of Rotigotine Transdermal Patch to That of Ropinirole on Early Morning Motor Impairment and Sleep Disorders in Subjects With Early-Stage, Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: SPM 962
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-world Study of Camrelizumab Alone or in Combination With Apatinib/Chemotherapy for Advanced Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer|RWS|PD-1 Immunotherapy
Interventions: DRUG: Camrelizumab|DRUG: apatinib|DRUG: chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Of Lapatinib With Carboplatin, Paclitaxel, and With or Without Trastuzumab In Metastatic Breast Cancer.
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: DRUG: lapatinib|DRUG: carboplatin|DRUG: trastuzumab|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Combined With Apatinib in Patients With PD-1 Antagonists Resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrogen Breath Test an Instrument to Predict Rifaximin-Response in Irritable Bowel Syndrome Predominant Diarrhea
Status: RECRUITING
Conditions: Irritable Bowel Syndrome|Irritable Bowel Syndrome With Diarrhea
Interventions: DRUG: Rifaximin|DEVICE: Glucose and lactulose hydrogen breath testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Potassium Targets Within the Normal Range in Intensive Care Patients
Status: COMPLETED
Conditions: Thoracic Surgery|Cardiac Surgery|Critically Ill
Interventions: DRUG: Potassium Chloride|DRUG: Potassium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cell Transplantation for Acute-on-chronic Liver Failure
Status: UNKNOWN
Conditions: Acute-On-Chronic Liver Failure
Interventions: PROCEDURE: mesenchymal stem cell transplantation or placebo infusion via peripheral vein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD
Status: RECRUITING
Conditions: Major Depressive Disorder|Bipolar Disorder|Unipolar Major Depression
Interventions: DEVICE: MagPro TMS Stimulator and coil|DEVICE: Thymatron System IV|DEVICE: Magnetic Resonance Imaging Scanner|OTHER: ECT device without stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Dopamine and Cognition
Status: COMPLETED
Conditions: Sulpiride's Effect on Striatal BOLD Signal During Working Memory Gating|Interaction of Sulpiride, Average Reward Rate and Evidence Accumulation|Interaction of Sulpiride, Average Reward Rate and Cognitive Effort
Interventions: DRUG: Sulpiride 400 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuropathic Pain After Lung Surgery
Status: COMPLETED
Conditions: Chronic Neuropathic Pain, Postoperative|Chronic Pain, Postoperative|Chronic Chemotherapy-induced Neuropathic Pain|Chronic Chemotherapy-induced Pain|Chronic Chemotherapy-induced Peripheral Neuropathy
Interventions: PROCEDURE: Thoracic surgery for lung cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antibiotic Loaded Cement After TKA
Status: COMPLETED
Conditions: Total Knee Arthoplasty
Interventions: PROCEDURE: total knee arthroplasty|DRUG: Tobramycin|DRUG: Gentamicin|DEVICE: Antibiotic cement spacer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Pediatrician Counseling About Infant Safe Sleep Using the Electronic Medical Record
Status: RECRUITING
Conditions: Sudden Infant Death|Sudden Unexplained Infant Death
Interventions: BEHAVIORAL: ISA-MI|OTHER: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fasting Study of Doxycycline Monohydrate Tablets 100 mg and Adoxa Tablets 100 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Doxycycline Monohydrate Tablets (100 mg|DRUG: Adoxa Tablets 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing Diagnostics Of Arrhythmia Events In Children Using Intelligent Telemetric Solutions
Status: UNKNOWN
Conditions: Arrhythmia|Children
Interventions: DEVICE: Prolonged telemetric Full Disclosure ECG recording.|DEVICE: Repeated 24 hours ECG Holter monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does Fish Oil Prevent Depression in Pregnancy and Postpartum?
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: EPA-rich fish oil supplement|DRUG: DHA-rich fish oil supplement|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION