pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Norethindrone-Ethinyl Estradiol in Healthy Female Adult Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Tipranavir low dose|DRUG: Tipranavir high dose|DRUG: Ritonavir low dose|DRUG: Ritonavir high dose|DRUG: Norethindrone-Ethinyl Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: PROCEDURE: Sentinel lymph node mapping|DRUG: Indocyanine Green (ICG)|DEVICE: near-infrared fluorescence (NIR) imaging (Pinpoint, Novadaq, Waterloo)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug Interaction Study of Avanafil and Enalapril or Amlodipine
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: avanafil and enalapril|DRUG: avanafil and amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Stent Deployment Techniques on Clinical Outcomes of Patient Treated With the CYPHER® Stent (S.T.L.L.R.)
Status: COMPLETED
Conditions: Coronary Stenosis
Interventions: DEVICE: CYPHER® Bx Velocity™ stent (sirolimus-eluting)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bifidobacterium Infantis NLS Super Strain for Celiac Disease Patients on a Gluten-free Diet With Persistent Gastrointestinal Symptoms
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium infantis NLS super strain (Natren LIFE START®2)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Upper Extremity Home Exercises in Patients With Scleroderma
Status: COMPLETED
Conditions: Scleroderma|System; Sclerosis
Interventions: OTHER: Upper Extremity Home Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Combination Treatment With IMO-2125 and Ribavirin in Naïve Hepatitis C-infected, Genotype 1 Patients
Status: COMPLETED
Conditions: Hepatitis C, Treatment Naïve, Genotype 1 Patients
Interventions: DRUG: IMO-2125|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare and Evaluate the Pharmacokinetic Characteristics and the Safety of Fimasartan in Hepatic Impairment Patients and Healthy Volunteers
Status: COMPLETED
Conditions: Essential Hypertension|Hepatic Impairment
Interventions: DRUG: fimasartan|DRUG: fimasartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Wound Dressings With Copper Oxide
Status: TERMINATED
Conditions: Pressure Ulcer|Diabetic Foot Ulcer
Interventions: DEVICE: MedCu Antibacterial Wound Dressings with Copper Oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Shortening the Etching Time on the Clinical Performance of Resin Composite Restorations in Primary Teeth
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Total etching time|OTHER: Half-reduced etching time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MGuard™ Prime Stent System Clinical Trial in Patients With Acute ST Elevation Myocardial Infarction
Status: TERMINATED
Conditions: ST Elevation Myocardial Infarction
Interventions: DEVICE: MGuard Prime|DEVICE: (BMS/DES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Management of Patients With Cardiac Implantable Electronic Devices
Status: UNKNOWN
Conditions: CARDIAC PACEMAKERS DEFIBRILLATOR ELECTROMAGNETIC
Interventions: DEVICE: MAGNET APPLICATION|DEVICE: REPROGRAMING|DEVICE: NO ACTION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 24 Hour Plasma Glucose Profiles Comparing Lispro Mix 75/25 vs. Glargine
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Lispro mix 75/25|DRUG: Glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Impedance Tomography Guided Assessment of Optimum PEEP Levels During Mechanical Ventilation in Lateral Decubitus Position
Status: COMPLETED
Conditions: Mechanical Ventilation|Bioelectrical Impedance
Interventions: PROCEDURE: PEEP level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Guidance of Ultrasound in Intensive Care to Direct Euvolemia
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DIAGNOSTIC_TEST: Serial ultrasound assessments for GDT|DIAGNOSTIC_TEST: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Miswak and Miswak Extract on Oral Malodor
Status: COMPLETED
Conditions: Oral Malodor|Halitosis
Interventions: OTHER: Miswak extract mouth wash|OTHER: Miswak stick|OTHER: Chlorohexidine gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumors|Solid Tumor|Solid Carcinoma|Solid Tumor, Adult|ccRCC|RCC, Clear Cell Adenocarcinoma|RCC|Kidney Cancer|Clear Cell Renal Cell Carcinoma|Renal Cell Carcinoma, Metastatic|Renal Cell Carcinoma Recurrent|Renal Cell Carcinoma, Clear Cell Adenocarcinoma|Glioblastoma|Glioblastoma, Adult|GBM|Glioblastoma Multiforme
Interventions: DRUG: Belzutifan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Internalizing in Preadolescents Exposed to Chronic Stress
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Stress|Anxiety|Depression
Interventions: BEHAVIORAL: Building a Strong Identity and Coping Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Safety and Efficacy of CHAM* for the Treatment of Diabetic Foot Ulcers
Status: TERMINATED
Conditions: Chronic Diabetic Foot Ulcers
Interventions: BIOLOGICAL: CHAM|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Infraclavicular Block: Decreased Incidence of Tourniquet Pain, Compared to Axillary Brachial Plexus Block?
Status: COMPLETED
Conditions: Tourniquet Pain
Interventions: PROCEDURE: Ultrasound guided peripheral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of HGT-1110 in Participants With Metachromatic Leukodystrophy
Status: ACTIVE_NOT_RECRUITING
Conditions: Metachromatic Leukodystrophy (MLD)
Interventions: BIOLOGICAL: HGT-1110
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Digital Cognitive Behavioural Therapy for Insomnia in Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: BEHAVIORAL: Digital Cognitive Behavioural Therapy for Insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (MK-3475-024/KEYNOTE-024)
Status: COMPLETED
Conditions: Non-Small Cell Lung Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse
Status: COMPLETED
Conditions: Dental Plaque
Interventions: DRUG: Fluoride|DRUG: Triclosan, fluoride|DRUG: Chlorhexidine Gluconate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Trial Between LHM Alone Vs LHM With Anterior Fundoplication In Achalasia Cardia
Status: UNKNOWN
Conditions: Achalasia Cardia
Interventions: PROCEDURE: Laparoscopic Heller's myotomy|PROCEDURE: Anterior Fundoplication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Comparison of Analgesia Methods Used for Spinal Surgery
Status: UNKNOWN
Conditions: Analgesia|Postoperative Pain
Interventions: DRUG: Magnesium|DRUG: Isotonic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Improve Access to PMTCT Services and Reduce HIV Transmission From Mother to Child
Status: COMPLETED
Conditions: Mother-to-child Transmission of HIV|Pregnancy
Interventions: OTHER: Enhanced CHW intervention|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Autologous Conditioned Serum After Anterior Cruciate Ligament Reconstructive Surgery
Status: COMPLETED
Conditions: Joint Instability
Interventions: PROCEDURE: ACL reconstructive surgery and ACS/ Orthokin application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Versus Standard Dialysate Sodium on 48h Ambulatory BP in Patients With Intradialytic Hypertension
Status: COMPLETED
Conditions: Intradialytic Hypertension|End Stage Kidney Disease
Interventions: OTHER: dialysis with low dialysate sodium concentration|OTHER: dialysis with standard dialysate sodium concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Autoimmune Diseases|Diabetes Mellitus|Endocrine System Diseases|Glucose Metabolism Disorders|Immune System Diseases|Metabolic Diseases
Interventions: DRUG: Glutamine vs. Placebo|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn
Status: UNKNOWN
Conditions: Transient Tachypnea of Newborn
Interventions: DEVICE: Nasal SIMV|DEVICE: nasal CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics and Tolerance of Nicotinamide Mononucleotide (NMN, 400mg/Day) in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Nicotinamide mononucleotide (NMN-C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparative Clinical Trial to Evaluate the Safety and Clinical Equivalence of Clotrimazole Troche/Lozenges USP, 10mg (Unique Pharmaceutical Laboratories, India) With Clotrimazole Troche 10mg (Roxane Laboratories Inc., USA) in Subjects With Oropharyngeal Candidiasis.
Status: UNKNOWN
Conditions: Oropharyngeal Candidiasis
Interventions: DRUG: Unique Pharmaceutical Laboratories, India|DRUG: Roxane Laboratories Inc., USA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: sitagliptin|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Improved Skin Whitening Outcomes Associated With Nicotinamide Fortified Consumption in 30 to 50- Year-old Women
Status: COMPLETED
Conditions: Skin Darken
Interventions: DIETARY_SUPPLEMENT: Wonderlab Nicotinamide Drink|DIETARY_SUPPLEMENT: Ordinary Drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Evaluation of the Safety and Effectiveness of the MitraClip System in the Treatment of Clinically Significant Functional Mitral Regurgitation
Status: COMPLETED
Conditions: Mitral Valve Insufficiency
Interventions: DEVICE: MitraClip|OTHER: standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient-oriented Randomized Pragmatic Feasibility Trial With rTMS in Depression and Anxiety
Status: UNKNOWN
Conditions: Major Depressive Episode|Major Depressive Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bounce Back Now: A Low-Cost Intervention to Facilitate Post-Disaster Recovery
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Bounce Back Now|BEHAVIORAL: enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VX-222 + Telaprevir + Ribavirin for 12 or 16 Weeks in Treatment-Naive Subjects With Genotype 1a Hepatitis C
Status: COMPLETED
Conditions: Chronic Hepatitis C Virus
Interventions: DRUG: VX-222|DRUG: telaprevir|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Upper Airway Toning for Improve the Compliance of CPAP
Status: UNKNOWN
Conditions: Sleep Apnea, Obstructive
Interventions: OTHER: CPAP|PROCEDURE: Upper Airway Toning for Improve the Compliance of CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Second Study to Assess Different Ablation Strategies in Achieving Long-Term Arrhythmia Control in Patients With Persistent or Long Standing Persistent Atrial Fibrillation
Status: TERMINATED
Conditions: Atrial Fibrillation
Interventions: OTHER: Pulmonary Vein Isolation procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died
Status: COMPLETED
Conditions: Pancreatitis, Acute Necrotizing
Interventions: DRUG: meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Single and Multiple Ascending Dose Study of LY3876602 in Healthy Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: LY3876602|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma of Unknown Primary|Recurrent Melanoma|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Recombinant Interferon Alfa-2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study Evaluating the Safety and Efficacy of ABT-981 in Patients With Erosive Hand Osteoarthritis
Status: COMPLETED
Conditions: Erosive Hand Osteoarthritis
Interventions: BIOLOGICAL: ABT-981|BIOLOGICAL: Placebo for ABT-981
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity.
Status: UNKNOWN
Conditions: Overweight|Diabetes Type 2
Interventions: PROCEDURE: Laparoscopic Sleeve Gastrectomy|PROCEDURE: Laparoscopic Roux-en-Y Gastric Bypass|DRUG: Advanced Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protective Effect of EPA on Cardiovascular Events
Status: COMPLETED
Conditions: Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
Interventions: DRUG: Eicosapentaenoic acid ethyl ester(EPADEL Capsule 300 TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment for Female Stress Urinary Incontinence
Status: COMPLETED
Conditions: Female Urinary Incontinence
Interventions: PROCEDURE: Indirect training of the PFMs via transversus abdominis|PROCEDURE: pelvic floor muscle training|PROCEDURE: home exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Misoprostol Dosing in BMI Greater Than 30
Status: COMPLETED
Conditions: Pregnancy Related|Obesity|Labor Onset and Length Abnormalities
Interventions: DRUG: 50 Micrograms Vaginal Misoprostol (Intervention)|DRUG: 25 Micrograms Vaginal Misoprostol (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Translating a Heart Disease Lifestyle Intervention Into the Community
Status: COMPLETED
Conditions: Obesity|Hyperlipidemia|Hypertension|Pre-diabetes|Diabetes
Interventions: BEHAVIORAL: Lifestyle Intervention|OTHER: Print Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Physical Restraints in Intensive Care Unit Patients
Status: RECRUITING
Conditions: Critically Ill|Intensive Care Unit Delirium|Delirium Confusional State|Agitation,Psychomotor
Interventions: OTHER: ARBORea decision-making tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation
Status: COMPLETED
Conditions: Smokeless Tobacco Cessation
Interventions: DRUG: Commit® nicotine lozenges (4 mg) & self-help materials|BEHAVIORAL: Commit® nicotine lozenges (4 mg) & phone counseling & self-help materials|BEHAVIORAL: Phone counseling & self-help materials
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy Evaluation of Lipids When Treated With Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
Status: COMPLETED
Conditions: Dyslipidemia|Coronary Heart Disease|Atherosclerosis|Stroke|Diabetes
Interventions: DRUG: Niacin|DRUG: Atorvastatin|DRUG: Simvastatin|DRUG: Ezetimibe|DRUG: Rosuvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veterans Enhanced Recovery Using Integrative Treatments Around Surgery
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Surgery|Knee Arthropathy
Interventions: DEVICE: Bridge|DEVICE: BFA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Health Literacy Enhancement Program Among Older Persons With Physical Multimorbidity
Status: COMPLETED
Conditions: Multiple Chronic Conditions；Diabetes；Hypertension
Interventions: OTHER: The Individual and Family Enhancement Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial to Compare Rebamipide/Nizatidine Combination Therapy With Nizatidine Monotherapy in Patients With Gastritis
Status: COMPLETED
Conditions: Gastritis
Interventions: DRUG: Mucotra SR Tablet 150mg|DRUG: Axid Capsule 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Viral Therapy in Treating Young Patients With Relapsed or Refractory Solid Tumors
Status: COMPLETED
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: wild-type reovirus|DRUG: cyclophosphamide|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthesia and Non-small Cell Lung Cancer Recurrence
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer|Surgery|Anesthesia
Interventions: DRUG: Propofol|DRUG: Inhaled anesthetics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of LOXO-305 Versus Investigator's Choice (IdelaR or BR) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: LOXO-305|DRUG: Idelalisib|DRUG: Bendamustine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endocrine Therapy Plus CDK4/6 in First or Second Line for Hormone (SONIA) Receptor Positive Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasm Female
Interventions: DRUG: CDK 4/6 inhibitor|DRUG: Non-Steroidal Aromatase Inhibitor|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperatory Recovery in Advanced Ovarian Cancer, Fast-Track Protocol vs. Classical Management
Status: COMPLETED
Conditions: Median Length of Stay|Readmission Rate|Surgery Related Complications Rate|Cost Per Patient Rate
Interventions: PROCEDURE: Fast-Track Protocol|PROCEDURE: Usual management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mindfulness-Based Diabetes Education for Adults With Elevated Diabetes Distress
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Mindfulness-Based Diabetes Education|BEHAVIORAL: Standard Diabetes Self-Management Education (DSME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Injection in the Treatment of Lateral Epicondylitis. Randomized Controlled Trial
Status: COMPLETED
Conditions: Epicondylitis, Lateral
Interventions: DRUG: plate-rich plasma|DRUG: saline (0.9 NACI)|DRUG: betametazon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Post-marketing Re-evaluation of WangBi Granules for Rheumatoid Arthritis
Status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Wangbi granules|DRUG: Wangbi granules simulant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROFAST Intervention in Precursor Multiple Myeloma
Status: RECRUITING
Conditions: Cancer Prevention|Weight Loss|Smoldering Waldenstrom Macroglobulinemia(WM)|MGUS|Fasting|Multiple Myeloma
Interventions: BEHAVIORAL: Prolonged Fasting Intervention|BEHAVIORAL: EDUCATION CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility Study of a Dose Increase by a Boost of Curietherapy in Pulse Dose Rate (PDR) Associated With the Extern Radiotherapy in Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer With Intermediate Risk
Interventions: RADIATION: curietherapy and radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of an Intravenous Drug in Pediatric Patients With Acute Asthma (0476-301)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: montelukast sodium|DRUG: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of Gatifloxacin for the Treatment of Bacterial Conjunctivitis
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: gatifloxacin|DRUG: moxifloxacin 0.5% eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery
Status: COMPLETED
Conditions: Colonic Neoplasms|Diverticulosis, Colonic
Interventions: DRUG: Nefopam|OTHER: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC
Status: NOT_YET_RECRUITING
Conditions: KRAS Mutation-Related Tumors|Advanced Lung Cancer|Refractory Tumor
Interventions: DRUG: Trametinib|DRUG: Anlotinib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial
Status: COMPLETED
Conditions: Heart Disease|Stroke|Ischemic Heart Disease|Myocardial Infarction
Interventions: DRUG: aspirin|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy
Status: COMPLETED
Conditions: Angle Closure Glaucoma
Interventions: DEVICE: The sequential technique|DEVICE: The pure Nd:YAG laser technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preventive Treatment of Pain After Dental Implant Surgery
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: DEXKETOPROFEN TROMETAMOL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study Evaluating the Safety and Efficacy of SKG0106 in Patients With Neovascular Age-related Macular Degeneration (nAMD)
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: GENETIC: SKG0106
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Of Palbociclib (PD-0332991) + Letrozole VS. Placebo+ Letrozole For 1st Line Treatment Of Asian Postmenopausal Women With ER+/HER2- Advanced Breast Cancer [PALOMA-4]
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: Palbociclib|DRUG: Letrozole|DRUG: Placebo|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Subretinal Lucentis for Hemorrhagic Age-related Macular Degeneration (AMD)
Status: WITHDRAWN
Conditions: Retinal Hemorrhage|Macular Degeneration
Interventions: DRUG: vitrectomy with subretinal lucentis|DRUG: vitrectomy with subretinal lucentis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Paclitaxel Plus Gemcitabine and Cisplatin in Bladder Cancer
Status: TERMINATED
Conditions: Urinary Bladder Neoplasms
Interventions: DRUG: Gemcitabine|DRUG: Paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cyclopofol Versus Propofol for Postoperative Delirium in Elderly Patients Having Orthopedic Surgery
Status: NOT_YET_RECRUITING
Conditions: Postoperative Delirium|Stroke
Interventions: DRUG: Cyclopofol|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: BIOLOGICAL: anti-thymocyte globulin|DRUG: Fludarabine|DRUG: Cyclophosphamide|RADIATION: Total Body Irradiation|DRUG: acetaminophen|DRUG: diphenhydramine|DRUG: methylprednisolone|BIOLOGICAL: bone marrow transplant|DRUG: MESNA|DRUG: mycophenolate mofetil|DRUG: prednisone|DRUG: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Restoring Sensitivity To Immunotherapy In Advanced Triple Negative Breast Cancer Exploiting Ceralasertib Priming Followed By Combined Durvalumab/Nab-Paclitaxel
Status: RECRUITING
Conditions: Triple Negative Breast Cancer Metastatic
Interventions: DRUG: Ceralasertib|DRUG: Durvalumab|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infant Formula and Toddler Drink Feeding Intervention
Status: TERMINATED
Conditions: Respiratory Infections in Children
Interventions: OTHER: Control Infant Formula|OTHER: Control Toddler Drink|OTHER: Experimental Infant Formula|OTHER: Experimental Toddler Drink|OTHER: Supplemental Formula for HM Group|OTHER: Toddler Drink for HM group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability and Effects of Mannitol in Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Oral D-Mannitol of Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label PoC Trial of Ganaxolone in Children With PCDH19 Female Pediatric Epilepsy and Other Rare Genetic Epilepsies
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Ganaxolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase I Dose Escalation Study of VS-5584 in Subjects With Advanced Non-Hematologic Malignancies or Lymphoma
Status: TERMINATED
Conditions: Non Hematologic Cancers|Metastatic Cancer|Lymphoma
Interventions: DRUG: VS-5584
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Theta Burst Stimulation (TBS) and Voluntary Trunk Rotation for Neglect
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: TMS and trunk rotation|DEVICE: Sham TMS and trunk rotation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypertension and Urine Protease Activity in Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia|Hypertension|Proteinuria|Pregnancy
Interventions: DIETARY_SUPPLEMENT: Sodium|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant
Status: UNKNOWN
Conditions: Asses Immunosuppression Modulation on Renal Recovery Post LT
Interventions: DRUG: Basiliximab 20 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of PDD During TURB for NMIBC
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer
Interventions: PROCEDURE: Transurethral resection of the bladder performed with PDD tecnique and Hexvix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Corneal Cross-linking in Subjects With Keratoconus
Status: RECRUITING
Conditions: Progressive Keratoconus
Interventions: COMBINATION_PRODUCT: NXL Energy 1|COMBINATION_PRODUCT: NXL Energy 2|COMBINATION_PRODUCT: NXL Energy 3|COMBINATION_PRODUCT: Sham Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Web-based Methodology Trial to Evaluate the Efficacy and Safety of Tolterodine ER in Subjects With Overactive Bladder
Status: TERMINATED
Conditions: Overactive Bladder
Interventions: DRUG: Tolterodine ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of BC Farmers' Market Nutrition Coupon Program on Diet Quality and Psychosocial Well-being of Low-income Adults
Status: COMPLETED
Conditions: Diet, Healthy|Health Risk Behaviors
Interventions: OTHER: Food coupons|OTHER: Nutrition skill-building
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Usage of LMA Protector on Patients Who Undergo Laparoscopic Surgery
Status: COMPLETED
Conditions: Laryngeal Mask Airway
Interventions: DEVICE: LMA Protector|DEVICE: Tracheal Intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Adults With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Upadacitinib|BIOLOGICAL: Pneumococcal 13-valent conjugate vaccine (PCV-13)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Sotorasib Combined With Chemotherapy for Second Line Treatment of Pancreas Cancer
Status: WITHDRAWN
Conditions: Pancreatic Cancer|Unresectable Pancreatic Cancer|Metastatic Pancreatic Cancer|KRAS P.G12C
Interventions: DRUG: Sotorasib|DRUG: Liposomal Irinotecan (nal-IRI)|DRUG: 5 Fluorouracil (5FU)|DRUG: Leucovorin (LV)|DRUG: Gemcitabine (GEM)|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Expanded Access to OKN-007 for Patients With Diffuse Midline Glioma, H3 K27-altered
Status: AVAILABLE
Conditions: Diffuse Midline Glioma, H3 K27M-Mutant|Diffuse Intrinsic Pontine Glioma
Interventions: DRUG: OKN-007
Study Type: EXPANDED_ACCESS
Clinical trial: Prevalence and Treatment of Urinary Incontinence in Women With Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Cystic Fibrosis|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: PROCEDURE: Pelvic floor training group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Characteristics and Prevalence of Viral Hepatitis E in Human Tissue and Cell Donors
Status: RECRUITING
Conditions: Hepatitis E
Interventions: DIAGNOSTIC_TEST: Elecsys Anti-HEV IgG, IgM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial of Single Microneedle Radiofrequency for Moderate-to-Severe Acne Vulgaris
Status: UNKNOWN
Conditions: Acne Vulgaris
Interventions: OTHER: Single Microneedle Radiofrequency therapy|OTHER: Photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simultaneous MEG or fMRI And INtracranial EEG
Status: COMPLETED
Conditions: Epilepsy|Healthy Volunteers
Interventions: PROCEDURE: MEG or fMRI And INtracranial EEG|PROCEDURE: fMRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Nasal Continuous Positive Airway Pressure (CPAP) Mask and Nasal Airway in Molar Tooth Extraction Under Deep Sedation
Status: RECRUITING
Conditions: Deep Sedation|Non-invasive Ventilation Support|Nasal Airway|Nasal CPAP Mask|Impacted Molar
Interventions: DEVICE: Non-invasive ventilation support equipment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole
Status: WITHDRAWN
Conditions: Squamous Cell Carcinoma|Head and Neck Neoplasms|Metastases, Neoplasm
Interventions: DRUG: 18F-fluoromisonidazole|PROCEDURE: PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the Accuracy of the INRatio Prothrombin Time (PT) Monitoring System With a New Test Strip for the Oral Anticoagulation Therapy Patient in the Presence of Heparin and Low Molecular Weight Heparin (e.g., Enoxaparin or Dalteparin)
Status: COMPLETED
Conditions: Coagulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Anagrelide vs. Hydroxyurea - Efficacy and Tolerability Study in Patients With Essential Thrombocythaemia
Status: COMPLETED
Conditions: Essential Thrombocythaemia
Interventions: DRUG: Anagrelide|DRUG: Hydroxyurea
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Efficacy of Early Administration of Clotinab in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Clotinab|DRUG: Clotinab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: exenatide once weekly|DRUG: metformin|DRUG: sitagliptin|DRUG: pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide Riboside in Ulcerative Colitis
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside Chloride|DIETARY_SUPPLEMENT: Placebo|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab
Status: COMPLETED
Conditions: Age Related Macular Degeneration|Diabetic Retinopathy
Interventions: DRUG: Acetazolamide|DRUG: Brimonidine tartarate|PROCEDURE: Anterior chamber paracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Acute Effect of Physical Activity on Blood Glucose in Pregnant Women
Status: COMPLETED
Conditions: Gestational Diabetes
Interventions: DIAGNOSTIC_TEST: Oral Glucose Tolerance Test|BEHAVIORAL: Inactivity|BEHAVIORAL: Physical activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: VIC-1911|DRUG: sotorasib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Oral S-1 Plus Irinotecan in Patients With Advanced Gastric Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: irinotecan|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer
Status: WITHDRAWN
Conditions: Adenocarcinoma of the Colon|Adenocarcinoma of the Rectum
Interventions: DRUG: Leucovorin|DRUG: Oxaliplatin|DRUG: 5-FU|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia
Status: RECRUITING
Conditions: Atrial Flutter|Tachycardia, Supraventricular|Tachycardia, Atrial Ectopic|Tachycardia, Reciprocating|Tachycardia Atrial|Tachycardia, Atrioventricular Nodal Reentry|Tachycardia, Paroxysmal|Fetal Hydrops
Interventions: OTHER: Prospective observational cohorts
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT)
Status: UNKNOWN
Conditions: Heparin-induced Thrombocytopenia
Interventions: DRUG: Warfarin, NOAC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Effectiveness and Safety in Subjects With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: BMS-986165|DRUG: Placebo for BMS-986165
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Levosimendan on Left Ventricular Systolic Function and Heart Failure After PCI in Patients With Acute Anterior Myocardial Infarction
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction|Heart Failure
Interventions: DRUG: Levosimendan|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Assessment of Surgical Correction of Patello-femoral Instability by EOS 3D Kinematics
Status: COMPLETED
Conditions: Patellofemoral Dislocation
Interventions: PROCEDURE: EOS 3D imaging protocol pre- and post-surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pleth Variability Index (PVI) as a Measure of Volume Status During Transcatheter Mitral Valve Repair
Status: COMPLETED
Conditions: Mitral Regurgitation
Interventions: DEVICE: PVI measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Pallidal With Subthalamic Deep Brain Stimulation for Cervical Dystonia
Status: NOT_YET_RECRUITING
Conditions: Cervical Dystonia
Interventions: PROCEDURE: GPi-DBS|PROCEDURE: STN-DBS|DEVICE: GPi-DBS devices|DEVICE: STN-DBS devices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT