pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody
Status: RECRUITING
Conditions: Solid Tumor, Adult|Relapsed Cancer|Refractory Cancer
Interventions: DRUG: HST-1011|BIOLOGICAL: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Compare the Efficacy and Tolerability of Tarafenacin 0.2 mg and Tarafenacin 0.4 mg to Placebo in Patients Suffering From Overactive Bladder.
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: Tarafenacin 0.2 mg|DRUG: Placebo|DRUG: Tarafenacin 0.4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MK-2206, Paclitaxel and Trastuzumab in Treating Patients With HER2-overexpressing Solid Tumor Malignancies
Status: COMPLETED
Conditions: Advanced Solid Tumors|Tumors|Cancer
Interventions: DRUG: MK-2206|DRUG: Paclitaxel|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors
Status: COMPLETED
Conditions: Brain Tumor|Glioblastoma
Interventions: DRUG: Dichloroacetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined HAIC, Lenvatinib and Pucotenlimab as Conversion Therapy for Unresectable Intrahepatic Cholangiocarcinoma
Status: RECRUITING
Conditions: Cholangiocarcinoma Non-resectable
Interventions: PROCEDURE: HAIC|DRUG: Lenvatinib plus pucotenlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess the Effects Of PF-04457845 On BOLD fMRI In Subjects With Post Traumatic Stress Disorder
Status: TERMINATED
Conditions: Post-Traumatic Stress Disorder
Interventions: DRUG: PF-04457845|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evolution Natriuretic Peptide Concentrations of B-type (BNP) During General Anesthesia Under Propofol and Sevoflurane Association in Patients Previously Sensitized to Anthracyclines
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Peptide Natriurétique de type B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Two Products of Apixaban 5mg Tablets in Healthy, Adult, Human Subjects
Status: COMPLETED
Conditions: Antithrombic Drug
Interventions: DRUG: Apixaban 5MG|DRUG: Eliquis 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reproducibility of Child-Turcotte-Pugh (CTP) Rating and NRL972 Pharmacokinetics in Patients With Cirrhosis
Status: COMPLETED
Conditions: Hepatic Cirrhosis
Interventions: DRUG: NRL972
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Retrospective Study With Patients Treated With STALIF® C or M and Ti or FLX Implants for 1 and 2 Levels
Status: NOT_YET_RECRUITING
Conditions: Degenerative Disc Disease|Grade 1 Spondylolisthesis|Retrolisthesis|Symptomatic Cervical Disc Disease
Interventions: DEVICE: STALIF®
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Slide Interpretation or Standard Surgical Pathology in Assessing Margin Status in Patients With Pancreatic Cancer Undergoing Surgery
Status: COMPLETED
Conditions: Pancreatic Cancer|Adenocarcinoma
Interventions: OTHER: cytology specimen collection procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Prophylactic Internal Iliac Artery Balloon Catheterization in the Management of Placenta Previa and Accreta
Status: COMPLETED
Conditions: Placenta Previa|Placenta Accreta
Interventions: PROCEDURE: prophylactic internal iliac artery balloon catheterization|DEVICE: Prophylactic internal iliac artery balloon|RADIATION: Radiology operation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Multi-ingredient Supplement Study: a Randomized Controlled Trial in Men and Women
Status: COMPLETED
Conditions: Skeletal Muscle Hypertrophy
Interventions: DIETARY_SUPPLEMENT: Whey protein-based supplement|DIETARY_SUPPLEMENT: Collagen protein-based supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Preterm Donor Human Milk Supplementation of Mother's Own Milk in VLBW Infants
Status: RECRUITING
Conditions: Prematurity
Interventions: DIETARY_SUPPLEMENT: donor human milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of End-Effector Robot-Assisted Gait Training Combined With Robotic Balance Training in Subacute Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: GEO|DEVICE: GEO and HUNOVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Comparison Between Epidural and Intravenous Patient-controlled Analgesia for Laparoscopic Gastrectomy
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: DRUG: Epidural PCA Ropivacaine|DRUG: IV PCA Fentanyl+nefopam+Ramosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioavailability and Pharmacodynamics of EPA and DHA From Fortified Soymilk and Capsules
Status: RECRUITING
Conditions: Healthy Diet
Interventions: OTHER: Algae Oil Fortified Soymilk|DIETARY_SUPPLEMENT: Algae Oil Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy
Status: TERMINATED
Conditions: Corneal Dystrophy, Epithelial Basement Membrane|Epithelial Recurrent Erosion Dystrophy|Corneal Erosions
Interventions: DEVICE: Cacicol20|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Respiratory Complications Associated With COVID-19 Using Umbilical Cord Mesenchymal Stromal Cells
Status: TERMINATED
Conditions: Covid19
Interventions: BIOLOGICAL: Allogeneic Wharton's jelly-MSCs (WJ-MSC)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Injection (Albumin-bound) for Neoadjuvant Treatment of Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer Stage
Interventions: DRUG: nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CCI-001 in Patients With Recurrent and/or Metastatic Solid Tumours
Status: RECRUITING
Conditions: Cancer: Recurrent and/or Metastatic Solid Tumours
Interventions: DRUG: CCI-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stromal Cells (MSC´s) in Renal Lupus
Status: RECRUITING
Conditions: Lupus Erythematosus, Systemic|Lupus Glomerulonephritis
Interventions: BIOLOGICAL: MSC treatment|DRUG: Standard of Care|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vinorelbine Tartrate and Paclitaxel in Treating Older Patients With Advanced Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Vinorelbine Tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uterine Electrical Activity Before and After Progesterone Treatment for Preterm Labor
Status: WITHDRAWN
Conditions: Preterm Labor
Interventions: DRUG: Experimental: Vaginal progesterone|DRUG: Experimental: Topical progesterone|DRUG: Experimental: Intramuscular progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of Trazodone Hydrochloride Prolonged-Release Tablets for Treatment of Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Trazodone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adalimumab in JIA-associated Uveitis Stopping Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Uveitis|JIA
Interventions: BIOLOGICAL: Adalimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Herbal Compound for Psoriasis
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis|Inflammation|Skin Diseases
Interventions: DIETARY_SUPPLEMENT: ZAX.1400.P03|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of a Probiotic, Lactobacillus Gasseri BNR17, on Body Composition and Weight Management in Overweight Adults
Status: COMPLETED
Conditions: Weight Management
Interventions: DIETARY_SUPPLEMENT: Lactobacillus gasseri BNR17™ capsule|OTHER: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of 2 Doses of MAP0010 in Asthmatic Children
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: 0.135mg MAP0010|DRUG: 0.25mg MAP0010
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Malignant Neoplasms of Brain
Interventions: BIOLOGICAL: PEP-3 vaccine|BIOLOGICAL: sargramostim|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Instrumental or Physical-Exercise Rehabilitation of Balance in Parkinson's Disease? (IPER-PD)
Status: COMPLETED
Conditions: Parkinson's Disease|Rehabilitation
Interventions: OTHER: Balance exercise|OTHER: Mobile platform exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse Managed Upper Body Strength Training in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Exercise-specific self-efficacy|BEHAVIORAL: Gentle chair exercise|BEHAVIORAL: upper body strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection
Status: TERMINATED
Conditions: Recurrent Clostridium Difficile Infection
Interventions: DRUG: Penn Microbiome Therapy - 001|DRUG: Penn Microbiome Therapy - 002|DRUG: Penn Microbiome Therapy - 003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bronchoprovocation Study to Evaluate the Pharmacodynamics of Albuterol Sulfate Inhalation Aerosol, eq 90 mcg Base
Status: UNKNOWN
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: 90 mcg Reference Product|DRUG: 180 mcg Reference Product|DRUG: 90 mcg Test Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Extra Virgin Olive Oil in People With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIETARY_SUPPLEMENT: High Phenolic Extra Virgin Olive Oil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dupilumab As An Adjunct For Subcutaneous Grass Immunotherapy
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Dupilumab|DRUG: Timothy Grass SCIT|DRUG: Placebo matching dupilumab|DRUG: Placebo matching SCIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody Combined With COX Inhibitor in MSI-H/dMMR or High TMB Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: PD-1 antibody + cox inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Cetuximab or Cetuximab Plus Docetaxel to Treat Prostate Cancer Before Prostatectomy
Status: TERMINATED
Conditions: Prostatic Neoplasms
Interventions: DRUG: cetuximab|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Three Experimental Drugs Compared With Telaprevir (a Licensed Product) in People With Hepatitis C Virus Infection Who Have Not Had Treatment Before
Status: COMPLETED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: ABT-450/r/ABT-267, ABT-333|DRUG: Ribavirin|DRUG: Telaprevir|DRUG: Pegylated Interferon alpha 2-a (PegIFN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web-based CBT4CBT for Alcohol
Status: COMPLETED
Conditions: Alcohol Abuse or Dependence
Interventions: BEHAVIORAL: Standard Treatment as Usual (TAU)|BEHAVIORAL: Web-based CBT4CBT for alcohol plus TAU|BEHAVIORAL: Web-based CBT with minimal clinical contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repeatability and Response Study of Absorptive Clearance Scans
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Absorptive clearance scan|DRUG: inhaled hypertonic saline (7%)|DRUG: mannitol inhalation powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transdermal Vagal Stimulation for POTS
Status: ACTIVE_NOT_RECRUITING
Conditions: Postural Orthostatic Tachycardia Syndrome
Interventions: OTHER: Stimulation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients
Status: COMPLETED
Conditions: Oropharyngeal Cancer|Oral Cancer
Interventions: DEVICE: Wooden spatula|DEVICE: Therabite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Three Restorative Protocols in MIH: a Randomized Controlled Clinical Study
Status: UNKNOWN
Conditions: Molar Incisor Hypomineralization
Interventions: PROCEDURE: Restorative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Cohort 4-period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Metformin|DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study Assessing Arrhythmia Mapping With the Multi-Electrode OPTRELL™ Mapping Catheter
Status: COMPLETED
Conditions: Scar-related Atrial Tachycardia|Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation|Tachycardia, Ventricular|Ventricular Premature Complexes
Interventions: DEVICE: OPTRELL Mapping Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combined Retinoic Acid,Arsenic Trioxide and Chemo for Newly-diagnosed APL
Status: UNKNOWN
Conditions: Acute Promyelocytic Leukemia
Interventions: DRUG: ATRA+Arsenic|DRUG: ATRA+Chemo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Carbon Dioxide (CO2) Acupulse Laser Treatment on Vaginal Elasticity.
Status: COMPLETED
Conditions: Exposure Laser
Interventions: DEVICE: CO2 AcuPulse Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparison of 188-0551 Spray Versus Vehicle Spray in Subjects With Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: 188-0551 Spray|DRUG: Vehicle Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Azacitidine in Combination With Pembrolizumab in R/R AML Patients and in Newly Diagnosed Older Patients
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: pembrolizumab|DRUG: Azacitadine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia
Status: RECRUITING
Conditions: Presbyopia
Interventions: DRUG: 0.75% phentolamine ophthalmic solution|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of High-risk Non-muscle Invasive Bladder Cancer With IMUNO BGC Moreau RJ as Prophylaxis
Status: UNKNOWN
Conditions: Bladder Cancer
Interventions: BIOLOGICAL: Instillation of IMUNO BCG Moreau RJ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin Use and Clinical Pregnancy Rate in Women With Unexplained Infertility
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Metformin|DRUG: Placebo|DRUG: Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Physical Therapy for Women With Obstetric Trauma and Anal Incontinence
Status: COMPLETED
Conditions: Sphincter Ani Incontinence|Obstetric Trauma
Interventions: BEHAVIORAL: Physical Therapy (PT) and Behavioral Therapy (BT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunodeficiency in Cartilage-hair Hypoplasia: Sub-project on Safety of Vaccination Against Chickenpox
Status: UNKNOWN
Conditions: Cartilage-hair Hypoplasia
Interventions: BIOLOGICAL: Varilrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of ABT-SLV176 for the Treatment of Hypogonadal Men
Status: WITHDRAWN
Conditions: Hypogonadism|Testosterone Deficiency
Interventions: DRUG: ABT-SLV176
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Management With Pecfent in the Prevention of Pain Induced by Position in Radiotherapy
Status: UNKNOWN
Conditions: Bone Metastasis
Interventions: DRUG: fentanyl transmucosal|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma
Status: COMPLETED
Conditions: Lymphoblastic Leukemia, Acute, Childhood|Lymphoblastic Lymphoma|Peripheral T-cell Lymphoma
Interventions: DRUG: Temsirolimus|DRUG: Etoposide|DRUG: Cyclophosphamide|DRUG: Methotrexate|DRUG: Hydrocortisone|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Effect of Ethanol-gelfoam Mixture for the Treatment of Arterioportal Shunts (APS) in Patients With HCC
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: PROCEDURE: TACE|DRUG: EGM|DRUG: PVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of the Efficacy and Safety of BCD-132 With Teriflunomide and Placebo in Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: BCD-132, 125 mg|DRUG: Teriflunomide|DRUG: Placebo|BIOLOGICAL: BCD-132, 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Benefits of Coffee
Status: COMPLETED
Conditions: Immune Senescence|Low-grade Inflammation
Interventions: DIETARY_SUPPLEMENT: Fully torrefied coffee|DIETARY_SUPPLEMENT: Partially torrefied coffee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perspective Evaluation of Hormones Involved in Serum Phosphate Homeostasis in Patients With Metastatic Renal Cells Carcinoma or Hepatocellular Carcinoma Treated With Sorafenib (SORHORM)
Status: UNKNOWN
Conditions: Kidney Cancer|Liver Cancer
Interventions: DRUG: Sorafenib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: RCT of Bibliotherapy for Social Anxiety Disorder as a Prelude to CBT in IAPT
Status: COMPLETED
Conditions: Bibliotherapy|Social Anxiety Disorder|Cognitive Behavioral Therapy
Interventions: PROCEDURE: Cognitive-Behavioural Bibliotherapy|PROCEDURE: Cognitive-Behavioural Therapy|OTHER: WAIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Randomized Study of Diazepam Vs Lorazepam Vs Placebo for Prehospital Treatment of Status Epilepticus
Status: COMPLETED
Conditions: Status Epilepticus
Interventions: DRUG: diazepam|DRUG: lorazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
Status: COMPLETED
Conditions: Hypotension|Fluid Therapy
Interventions: DRUG: phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Performance of the ID-Cap System, an Ingestion Event Marker, in the Clinical Setting as an Aid to Measure Medication Adherence
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: ID-Capsule- Active|DEVICE: Wearable Sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Speech in Noise Discrimination Skills in Multiple Sclerosis Patients.
Status: COMPLETED
Conditions: Multiple Sclerosis-Relapsing-Remitting
Interventions: DIAGNOSTIC_TEST: Hearing test|DIAGNOSTIC_TEST: Speech in noise discrimination test|DIAGNOSTIC_TEST: Montreal Cognitive Assessment Scale|DIAGNOSTIC_TEST: Symbol Number Modalities Test (SDMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rapid Maxillary Expansion With Low Level Laser Therapy
Status: RECRUITING
Conditions: Crossbite|Malocclusion|Cross Bite|Maxillary Constriction
Interventions: DEVICE: Bonded-Hyrax|COMBINATION_PRODUCT: Bonded Rapid Maxillary Expansion and low-Level Laser therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy Using HPPH in Treating Patients With Recurrent Dysplasia, Carcinoma in Situ, or Stage I Oral Cavity Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: HPPH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Multicenter Randomized HYpertension and VALUEs (HYVALUE) Trial
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Intervention Values Affirmation|BEHAVIORAL: Control Values Affirmation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Nasal Mucosal Permeability in Controls and House Dust Mite Allergic Rhinitis Patients
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: OTHER: healthy controls|OTHER: AR patients without medication|OTHER: AR patients with use of nasal corticoid spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hydration and Exercise Performance in Cycling
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Hypotonic|DIETARY_SUPPLEMENT: Isotonic|DIETARY_SUPPLEMENT: Placebo|OTHER: Dehydrated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Behavioral Health Homes for Adults With Serious Mental Illness
Status: COMPLETED
Conditions: Chronic Disease|Mental Health|Behavioral Health|Cardiovascular Disease|Diabetes Mellitus Type 2|Substance-related Disorders|Vascular Diseases
Interventions: BEHAVIORAL: Patient Self-Directed Care|BEHAVIORAL: Provider-Supported Integrated Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Exploratory Study of Continuous Theta Burst Stimulation (cTBS) Based on fMRI in the Treatment of Tic Disorder
Status: COMPLETED
Conditions: Tic Disorders|Tourette Syndrome
Interventions: DEVICE: traditional stimulation site continuous theta burst stimulation (cTBS)|DEVICE: precise stimulation site cTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Fungal Infection
Interventions: DRUG: liposomal amphotericin B (AmBisome®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Understanding Paratyphoid Infection
Status: COMPLETED
Conditions: Enteric Fever Caused by Salmonella Enterica Serovar Paratyphi A
Interventions: BIOLOGICAL: Salmonella enterica serovar Paratyphi A (strain NVGH308)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study To Assess The Efficacy And Safety Of PF-04236921 In Subjects With Crohn's Disease Who Failed Anti-TNF Therapy
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: PF-04236921 SC injection|DRUG: PF-04236921 SC injection|DRUG: PF-04236921 SC injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib and Pembrolizumab in Differentiated Thyroid Cancers (DTC)
Status: COMPLETED
Conditions: Columnar Cell Variant Thyroid Gland Papillary Carcinoma|Follicular Variant Thyroid Gland Papillary Carcinoma|Metastatic Thyroid Gland Follicular Carcinoma|Metastatic Thyroid Gland Papillary Carcinoma|Poorly Differentiated Thyroid Gland Carcinoma|Recurrent Differentiated Thyroid Gland Carcinoma|Recurrent Thyroid Gland Follicular Carcinoma|Recurrent Thyroid Gland Papillary Carcinoma|Stage III Differentiated Thyroid Gland Carcinoma AJCC v7|Stage III Thyroid Gland Follicular Carcinoma AJCC v7|Stage III Thyroid Gland Papillary Carcinoma AJCC v7|Stage IV Thyroid Gland Follicular Carcinoma AJCC v7|Stage IV Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v7|Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v7|Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7|Stage IVC Differentiated Thyroid Gland Carcinoma AJCC v7|Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7|Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7|Tall Cell Variant Thyroid Gland Papillary Carcinoma|Thyroid Gland Hurthle Cell Carcinoma|Unresectable Differentiated Thyroid Gland Carcinoma|Unresectable Thyroid Gland Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lenvatinib|DRUG: Lenvatinib Mesylate|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhanced Versus Extended Preoperative Antibiotic Prophylaxis Regimens for Retrograde Intrarenal Surgery in High Infectious Risk Patients
Status: RECRUITING
Conditions: Renal Stone
Interventions: DRUG: Enhanced regimen|DRUG: Extended regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High Dose IV Iron Plus ESA in Chemotherapy-induced Anemia
Status: RECRUITING
Conditions: Anemia
Interventions: DRUG: Ferric Derisomaltose Injection|DRUG: Darbepoetin Alfa Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Resveratrol From Vineatrol30 Extract Incorporated Into Micelles
Status: COMPLETED
Conditions: Safety After Oral Intake|Pharmacokinetics After Oral Intake
Interventions: DIETARY_SUPPLEMENT: Vineatrol 30 native powder|DIETARY_SUPPLEMENT: Vineatrol 30 micelles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topotecan Plus Paclitaxel and Carboplatin in the Initial Treatment of Advanced Ovarian and Primary Peritoneal Carcinoma
Status: COMPLETED
Conditions: Ovary Cancer
Interventions: DRUG: Topotecan|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LANN-study: Lantus, Amaryl, Novorapid, Novomix Study
Status: COMPLETED
Conditions: Diabetes Mellitus Type II
Interventions: DRUG: Novomix 30|DRUG: Novorapid and Amaryl|DRUG: Lantus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination With Flt3L, Radiation, and Poly-ICLC
Status: RECRUITING
Conditions: Non-Hodgkin's Lymphoma|Metastatic Breast Cancer|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Flt3L|RADIATION: Radiation|DRUG: Poly ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: BIOLOGICAL: tanezumab|DRUG: diclofenac|BIOLOGICAL: tanezumab|DRUG: diclofenac|BIOLOGICAL: tanezumab|DRUG: diclofenac|DRUG: diclofenac|OTHER: IV placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research on the Clinical Effect of Effective Prescription in Treating Unstable Angina.
Status: UNKNOWN
Conditions: Unstable Angina
Interventions: DRUG: Anti-Platelet Drugs|DRUG: Lipid Regulating Drugs|DRUG: Coronary Vasodilator|DRUG: Xuefu Zhuyu Decoction|DRUG: Gualou Xiebai Banxia Decoction & Danshen Decoction|DRUG: Shuanghe Decoction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temperature-dependent Changes in Cardiovascular Parameters During Warm Water Footbaths in Healthy Women
Status: COMPLETED
Conditions: Warm Footbath|Cardiovascular System|Autonomic Nervous System
Interventions: OTHER: 38°C warm water footbath|OTHER: 40°C warm water footbath|OTHER: 42°C warm water footbath|OTHER: 38-42°C rising temperature footbath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Stapokibart Injection in Patients With Allergic Rhinitis
Status: NOT_YET_RECRUITING
Conditions: Allergic Rhinitis
Interventions: BIOLOGICAL: Stapokibart Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment
Status: COMPLETED
Conditions: Intravitreal Bevacizumab Injection|Pars Plana Vitrectomy|Tractional Retinal Detachment|Diabetic Retinopathy
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Id and Rd Maintenance Regimens After Induction of Remission in Multiple Myeloma.
Status: RECRUITING
Conditions: Progression Free Survival|Overall Survival|Maintenance
Interventions: DRUG: Ixazomib DX/Lenalidomide DX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of High Protein Diet on the Large Intestine in Overweight Humans
Status: COMPLETED
Conditions: Overweight|Healthy
Interventions: DIETARY_SUPPLEMENT: casein supplementation|DIETARY_SUPPLEMENT: soy protein supplementation|DIETARY_SUPPLEMENT: maltodextrin supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Interscalene Block on Wound Healing and Immunity in Open Shoulder Surgeries
Status: ACTIVE_NOT_RECRUITING
Conditions: Ultrasound gıided Interscalene Block
Interventions: PROCEDURE: ultrasoud guided interscalene block|PROCEDURE: general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Effect of Sensorial Biodex Balance Balance System Exercises in Diabetic Neuropathy
Status: COMPLETED
Conditions: Diabetic Neuropathies|Diabetes Mellitus|Exercise Training
Interventions: DEVICE: Biodex Balance Exercise System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Metronidazole Ointment in Non-healing Pilonidal Sinus Wounds
Status: UNKNOWN
Conditions: Pilonidal Sinus
Interventions: DRUG: Metronidazole 10% ointment|DRUG: Placebo ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CE-IOUS for Patients With Pancreatic Cancer Undergoing Surgery: A Prospective, Proof-of-concept Trial
Status: UNKNOWN
Conditions: Pancreatic Cancer|Liver Metastases
Interventions: OTHER: Contrast-enhanced Intraoperative Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety of KAI-9803 for Injection With Angioplasty Following Heart Attack
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: KAI-9803 for Injection|DRUG: KAI-9803 for Injection|DRUG: KAI-9803 for Injection|DRUG: KAI-9803 for Injection|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Tetomilast in Chronic Obstructive Pulmonary Disease (COPD) Associated With Emphysema
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: tetomilast|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Initiation of Antiretroviral Therapy to Promote Early HIV/AIDS Treatment in South Africa (RapIT Study)
Status: COMPLETED
Conditions: HIV
Interventions: OTHER: Rapid ART initiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatitis B, Chronic
Interventions: DRUG: GSK3228836|BIOLOGICAL: GSK3528869A|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Early Palliative Care in Metastatic Esophageal Squamous Carcinoma (ESCC) and Gastric Cancer
Status: UNKNOWN
Conditions: Metastatic Esophageal Squamous Carcinoma|Gastric Cancer
Interventions: OTHER: Palliative care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cold Exposure and Breathing Techniques on Immune Response
Status: COMPLETED
Conditions: Cold Exposure|Hyperventilation|Inflammation|Endotoxemia
Interventions: BEHAVIORAL: Cold Exposure|BEHAVIORAL: Strength Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion
Status: WITHDRAWN
Conditions: Corneal Abrasion
Interventions: DRUG: Tetracaine 0.5% ophthalmic drops|DRUG: Normal Saline placebo drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 1-year Trial to Inform About Long-term Exposure to Eptinezumab in Participants With Chronic Cluster Headache (cCH)
Status: COMPLETED
Conditions: Chronic Cluster Headache
Interventions: DRUG: Eptinezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paleo Versus Healthy ADA Diets for Treatment of Polycystic Ovarian Syndrome (PCOS)
Status: COMPLETED
Conditions: Polycystic Ovarian Syndrome
Interventions: OTHER: Paleolithic diet|OTHER: American Diabetes Association diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decision Aid for Therapeutic Options In Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease|Sickle Cell Anemia|Hemoglobin SS|Hemoglobin SC|Hemoglobin Beta Thalassemia
Interventions: OTHER: Decision Aid Tool|OTHER: Standard Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Glucagon and Glucagon-like Peptide-1 Co-agonism on Cardiac Function and Metabolism in Overweight Participants With Type 2 Diabetes
Status: UNKNOWN
Conditions: Type 2 Diabetes|Obesity
Interventions: DRUG: 0.9% Sodium-chloride|DRUG: Exenatide (50ng/min for 30 minutes loading followed by 25ng/min maintenance) and glucagon 12.5ng/kg/min|DRUG: Glucagon 12.5ng/kg/min and 0.9% saline|DRUG: 0.9% Sodium-chloride|DRUG: Exenatide (50ng/min for 30 minutes loading followed by 25ng/min maintenance) and glucagon 12.5ng/kg/min|DRUG: Glucagon 12.5ng/kg/min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome
Status: RECRUITING
Conditions: Stroke, Acute|Hypoxia-Ischemia, Brain|ENDOVASCULAR TREATMENT
Interventions: OTHER: oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Propofol vs Placebo in the Prevention of Coughing During Emergence of General Anesthesia Under Desflurane
Status: COMPLETED
Conditions: Elective Surgery|Coughing
Interventions: DRUG: Intravenous dose of 0.5 mg/kg of propofol|DRUG: Intravenous dose of 0.05 mL/kg of saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Differential Trough Effects of 'Triple Therapy' on Pulmonary Function in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Budesonide/formoterol and tiotropium|DRUG: Budesonide/formoterol and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pioglitazone for Heroin and for Nicotine Dependence
Status: TERMINATED
Conditions: Heroin Dependence|Nicotine Dependence
Interventions: DRUG: PIO|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Effects of Indacaterol Maleate as a New Formulation in the Concept 1 Device
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: 75 µg indacaterol maleate (LB)|DRUG: 75 µg indacaterol maleate (PoS)|DRUG: 37.5 µg indacaterol maleate (PoS)|DRUG: placebo to indacaterol (LB)|DRUG: placebo to indacaterol (PoS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Oral Health With Serious Games
Status: COMPLETED
Conditions: Caries|Tooth Decay|Cavities|Gingivitis
Interventions: OTHER: Attack of the S. Mutans|OTHER: Follow-up|OTHER: SnowWorld
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Optimal Number of To-and-fro Motion in EUS-guided Fine Needle Aspiration for Pancreatic Masses
Status: COMPLETED
Conditions: Pancreatic Masses
Interventions: PROCEDURE: EUS-FNA|DEVICE: EUS-FNA with suction|DEVICE: EUS-FNA without suction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy
Status: RECRUITING
Conditions: Chemotherapy-induced Neuropathy
Interventions: OTHER: In-person training for seed placement and APA|OTHER: Virtual training for seed placement and APA|OTHER: Usual Care|OTHER: Post-training zoom session for seed placement and APA coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: PROCEDURE: Allogenic bone graft|PROCEDURE: Synthetic bone substitute (geneX®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT