pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy
Status: RECRUITING
Conditions: Hereditary Amyloidosis, Transthyretin-Related|Asymptomatic Carrier State
Interventions: OTHER: Standard of Care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Standard of Care vs. Bortezomib in Graft-Versus Host Disease After Hematopoietic Stem Cell Transplant
Status: COMPLETED
Conditions: Graft Versus Host Disease
Interventions: DRUG: Tacrolimus|DRUG: Methotrexate|DRUG: Bortezomib|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Key Link for Transmission Prevention
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Standard HIV prevention messages|BEHAVIORAL: BI: Information-Motivation-Behavioral Skills Model|DRUG: Raltegravir|DRUG: emtricitabine/tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optimizing Recruitment to Drive Equitable Research Opportunity in Stroke Rehabilitation Trials in Canada
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: OTHER: Supported, women-centred and aphasia-friendly recruitment and enrollment process (ORDER)|OTHER: Traditional recruitment and enrollment processes (TRAD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Application of I-gel Laryngeal Mask Airway in Pediatric Patients
Status: COMPLETED
Conditions: the Efficacy and Performance of the Pediatric I-gel Mask
Interventions: DEVICE: laryngeal mask airway
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of CPI-613 With Gemcitabine and Nab-paclitaxel for Patients With Advanced or Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer|Metastatic Pancreatic Cancer
Interventions: DRUG: CPI 613 in Combination With Gemcitabine and Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Degenerative Achilles Tendon Rupture Repair With Regeneten Augmentation
Status: NOT_YET_RECRUITING
Conditions: Achilles Tendon Rupture|Achilles Tendinopathy
Interventions: PROCEDURE: Achilles Tendon Repair augmented with Bioinductive Collagen Patch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rate RESPONSIVe Pacing in Patients With Permanent AF Underwent AV Node ABLation and bivEntricular Pacing (RESPONSIBLE)
Status: COMPLETED
Conditions: Left Ventricular Dysfunction|Atrial Fibrillation
Interventions: DEVICE: Rate Response on first (VVI biventricular pacing)|DEVICE: Rate Response off first (VVI biventricular pacing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Fractional Flow Reserve Calculated by Computed Tomography Coronary Angiography in Patients Undergoing TAVR
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Coronary Artery Disease
Interventions: DEVICE: iFR / FFR measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Anticoagulation Therapy After Splenectomy in Cirrhosis Patient
Status: COMPLETED
Conditions: Liver Cirrhosis|Portal Hypertension|Anticoagulant-induced Bleeding|Thrombosis
Interventions: DRUG: Heparin and Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics
Status: COMPLETED
Conditions: Idiopathic Hypercalciuria|Hypokalemia Caused by Thiazide Diuretics
Interventions: DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy
Status: TERMINATED
Conditions: Pain|Hernia
Interventions: DRUG: Ibuprofen|DRUG: Opioid Medication|DRUG: Placebo|DRUG: Ibuprofen + Opioid medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Twice for Pain Treatment of Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Fibrin in the Treatment of Localized Gingival Recessions
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Subepithelial connective tissue graft|PROCEDURE: Platelet Rich Fibrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AlloGen® Liquid Intra-articular Injection for Knee Osteoarthritis
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee
Interventions: BIOLOGICAL: AlloGen Liquid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brodalumab (AMG 827) in Rheumatoid Arthritis (RA) Participants With Inadequate Response to Methotrexate
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Brodalumab|DRUG: Placebo|DRUG: Methotrexate|DIETARY_SUPPLEMENT: folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Pharmacodynamics of Canagliflozin and Dapagliflozin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Canagliflozin|DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Normobaric Hyperoxygenation for Prevention of Contrast Induced Nephropathy
Status: UNKNOWN
Conditions: Nephropathy
Interventions: DRUG: 100% oxigen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Docetaxel, Vinorelbine and Trastuzumab in the Treatment of Patients With Metastatic Her-2 Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel|DRUG: Vinorelbine|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration
Status: ACTIVE_NOT_RECRUITING
Conditions: Age-Related Macular Degeneration
Interventions: BIOLOGICAL: OpRegen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jalosome® Soothing Gel Efficacy Grade 2 or 3 Radiodermatitis.
Status: WITHDRAWN
Conditions: Radiodermatitis|Oncology|Quality of Life|Pain
Interventions: DEVICE: Jalosome soothing gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy (Effectiveness) of Paliperidone Palmitate in the Prevention of Recurrence of the Symptoms of Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: Paliperidone Palmitate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cetuximab/Paclitaxel/Cisplatin Concurrent Chemoradiotherapy Followed by Esophagectomy for Loco-regional Esophageal Cancer
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: Cetuximab|DRUG: Paclitaxel|DRUG: Cisplatin|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Tolerability and Efficacy of Anacetrapib (MK-0859) Co-Administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020)
Status: COMPLETED
Conditions: Hyperlipoproteinemia Type II|Hypercholesterolemia, Familial
Interventions: DRUG: Anacetrapib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness of Ultrasound and Paraffin Therapy in Patients With Carpal Tunnel Syndrome: A Randomized Trial
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DEVICE: ultrasound|PROCEDURE: paraffin therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The SNAP Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Neuropathic Post-Amputation Pain
Status: TERMINATED
Conditions: Neuropathic Pain|Amputation
Interventions: DEVICE: SPRINT Peripheral Nerve Stimulation (PNS) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Locally Advanced Rectal Cancer
Interventions: DRUG: AK104|DRUG: Capecitabine|RADIATION: Neoadjuvant Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulation for Post-Traumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: DEVICE: Trigeminal Nerve Stimulation|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Carbloading and Maltodextrin on the Level of Function in Patients With Apoplexia
Status: COMPLETED
Conditions: Apoplexy; Brain
Interventions: DIETARY_SUPPLEMENT: Carbloading and maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Pre-hospital Treatment of Acute Myocardial Infarction Based on Diagnosis by Interpretation of Remotely Acquired ECG and Thrombolysis With Accelerated Alteplase ( Actilyse®)
Status: TERMINATED
Conditions: Myocardial Infarction
Interventions: DRUG: Alteplase (Actilyse)|DRUG: Standard therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Blood Cell Collection for Future Use in Individuals With Fanconi Anemia
Status: COMPLETED
Conditions: Fanconi Anemia
Interventions: PROCEDURE: PBSC Collection|PROCEDURE: Bone Marrow Harvest|DEVICE: CliniMacs Cell Selection System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients
Status: COMPLETED
Conditions: ESRD|Diabetes|CAPD|APD
Interventions: DRUG: Physioneal|DRUG: Dianeal|DRUG: Extraneal|DRUG: Nutrineal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional Cure Study of Anti-PD-L1 Antibody ASC22 in Combination With Chidamide in HIV-infected Patients With Antiviral Suppression
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: ASC22 group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Trial of Egg- Versus Non-Egg-Based Influenza Vaccines Among HCP
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Flublok|BIOLOGICAL: Flucelvax|BIOLOGICAL: Fluarix|BIOLOGICAL: Fluzone|BIOLOGICAL: Fluzone High-Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Personalized tactile cueing|DEVICE: Fixed tactile cueing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06372865 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56-75 Years (Group 2)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06372865|DRUG: Placebo|DRUG: PF-06372865|DRUG: Placebo|DRUG: PF-06372865|DRUG: Placebo|DRUG: PF-06372865|DRUG: Placebo|DRUG: PF-06372865|DRUG: Placebo|DRUG: PF-06372865
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Trial of Carboplatin +/- Tocilizumab for Metastatic Triple Negative and ER-low Breast Cancers
Status: RECRUITING
Conditions: Metastatic Breast Cancer|Triple Negative Breast Cancer|Estrogen-receptor-low Breast Cancer
Interventions: DRUG: Carboplatin|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: clindamycin phosphate 1.2% and tretinoin 0.025%|DRUG: clindamycin 1% gel|DRUG: tretinoin 0.025% cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Infant Formula With Partially Hydrolyzed Cow's Milk Protein Versus a Formula With Intact Protein
Status: UNKNOWN
Conditions: Infant Colic
Interventions: DIETARY_SUPPLEMENT: Partially hydrolyzed formula (pHF)|DIETARY_SUPPLEMENT: Standard formula (SF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Abemaciclib in Combination With Sunitinib in Metastatic Renal Cell Carcinoma
Status: TERMINATED
Conditions: Renal Cell Carcinoma Metastatic
Interventions: DRUG: Abemaciclib|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability Study of Candesartan Cilexetil 8mg Tablet Under Fasting Conditions
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan cilexetil (GW615775, Test formulation)|DRUG: Candesartan cilexetil (Reference treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Local Dry Heat Applıcatıon and Half Shower on The Development of Urinary Retentıon and Paın
Status: COMPLETED
Conditions: Spinal Anesthesia|Nursing|Bladder Retention|Dry Heat Application|Half Shower|Pain
Interventions: OTHER: half-shower and hot pack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Acceptance and Commitment Therapy on Impulsivity and Suicidality Among Clients With Bipolar Disorders
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: acceptance and commitment therapy|OTHER: routine hospital care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of the Journey Total Knee Arthroplasty Versus Two Standard of Care Total Knee Arthroplasty Prostheses
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Journey II|DEVICE: Stryker|DEVICE: Zimmer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DRUG: Duloxetine|DRUG: Pregabaline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Action Observation Training on Gait Variables and Global Cognitive Functions
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: PROCEDURE: AOT with gait training|PROCEDURE: Gait training|OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate White Matter Hyperintensities in Migraine
Status: ACTIVE_NOT_RECRUITING
Conditions: Migraine|Small Vessel Ischemic Disease|Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: Brain Neuroimaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
Status: COMPLETED
Conditions: Septic Shock|Sepsis
Interventions: DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fecal Microbiota Transplant for Secondary Prophylaxis of Hepatic Encephalopathy
Status: UNKNOWN
Conditions: Hepatic Encephalopathy
Interventions: OTHER: Standard Medical Treatment|OTHER: Fecal Microbiota Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Dietitians Reduce Interdialytic Weight Gain in at Risk Hemodialysis Patients Through Tailored Education on Dietary Sodium and Fluid Intake?
Status: COMPLETED
Conditions: End Stage Renal Disease Requiring Hemodialysis
Interventions: BEHAVIORAL: Intensive Tailored Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Pharmacokinetics of DP-R207 in Comparison to Each Component Administered Alone
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DP-R207|DRUG: Rosuvastatin|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery
Status: TERMINATED
Conditions: Opioid Dependence|Chronic Pain
Interventions: DRUG: Ketamine|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lysosomal Acid Lipase (LAL) Deficiency Registry
Status: RECRUITING
Conditions: Lysosomal Acid Lipase Deficiency|Cholesterol Ester Storage Disease|Wolman Disease|Acid Cholesteryl Ester Hydrolase Deficiency, Type 2|Acid Lipase Deficiency|LIPA Deficiency|LAL-Deficiency
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Safety, Tolerability, and Efficacy of Viltolarsen in Ambulant and Non-Ambulant Boys With DMD (Galactic53)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Viltolarsen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib and PTK787/ZK222584 in Refractory and/or Advanced Solid Tumors
Status: COMPLETED
Conditions: Refractory Malignancy|Solid Tumors
Interventions: DRUG: Imatinib and PTK/ZK222584
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Angioplasty/Drug Coated Balloon/Laser + Drug Coated Balloon for Femoropopliteal Artery In-stent Restenosis
Status: UNKNOWN
Conditions: Angioplasty, Balloon
Interventions: DEVICE: Drug-coated balloons|DEVICE: Excimer Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trazodone on OSA Endotypes
Status: RECRUITING
Conditions: Obstructive Sleep Apnea
Interventions: DRUG: Placebo oral tablet|DRUG: Trazodone Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of an Innovative Physiotherapy in Patients With Infantile Spinal Muscular Atrophy (SMA)
Status: COMPLETED
Conditions: Infantile Spinal Muscular Atrophy of Type 2 or 3
Interventions: OTHER: Physical exercise in a swimming pool during 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Belinostat + Carboplatin or Paclitaxel or Both in Patients With Ovarian Cancer in Need of Relapse Treatment
Status: COMPLETED
Conditions: Ovarian Cancer|Epithelial Ovarian Cancer|Fallopian Tube Cancer|Bladder Cancer
Interventions: DRUG: belinostat|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of t:Slim X2 With Control-IQ Technology
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: t:slim X2 with Control-IQ Technology & Dexcom G6 CGM|DEVICE: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Phase 1 Study of Novel GS-9973 Tablet Formulations to Evaluate the Effect of Acid Reducing Agents, Relative Bioavailability, and Food Effect on GS-9973 Pharmacokinetics
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Treatment A|DRUG: Treatment B|DRUG: Treatment C|DRUG: Treatment D|DRUG: Treatment E|DRUG: Treatment F|DRUG: Treatment G|DRUG: Treatment H|DRUG: Treatment I|DRUG: Treatment J
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
Status: RECRUITING
Conditions: Neurotrophic Keratopathy
Interventions: DRUG: RGN-259|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Local Anesthetic Volume Within the Adductor Canal on Quadriceps Function Evaluated by Electromyography
Status: COMPLETED
Conditions: Knee Arthroplasty, Total
Interventions: DRUG: Lidocaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT Steel (Wallstent®) vs Nitinol (Wallflex®) Bile Duct Stent for Palliation of Malignant Obstruction
Status: COMPLETED
Conditions: Biliary Tract Neoplasms|Pancreatic Neoplasms|Stent Occlusion
Interventions: DEVICE: Steel|DEVICE: Nitinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study Investigating the Treatment Satisfaction of Atopic Dermatitis Patients Who Have Switched to Ointment (W/O Emulsion) Formulation of Very Strong Class Topical Corticosteroids
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: Diflucortolone valerate (Nerisona)|DRUG: Diflucortolone valerate (Texmeten)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Application Study of 12G Pigtail Catheter Used for Post-operative Drainage After Thoracoscopic Surgery for Mediastinal Nodes
Status: UNKNOWN
Conditions: Mediastinal Nodes
Interventions: DEVICE: 12G pigtail catheter|DEVICE: 16F chest tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib First in Human Dose Escalation of GT103 in Refractory, Advanced Stage Non-Small Cell Lung Cancer (TOP 1902)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: GT103
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Smecta in Combination With Oral Rehydration in the Treatment of Acute Watery Diarrhoea in Infants and Children
Status: COMPLETED
Conditions: Diarrhoea
Interventions: DRUG: Smecta (Diosmectite), duration of treatment - 7 days
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sugammadex Versus Neostigmine During Neuromuscular Blockade Reversal
Status: COMPLETED
Conditions: Neuromuscular Blockade
Interventions: DRUG: Sugammadex vs Neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buoy Electrolyte Study on Hydration Status of Active Men and Women
Status: COMPLETED
Conditions: Dehydration|Electrolyte Imbalance|Electrolyte Depletion|Fluid and Electrolyte Imbalance
Interventions: DIETARY_SUPPLEMENT: Buoy Electrolyte|DIETARY_SUPPLEMENT: Nuun|OTHER: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fecal Transplantation Using a Diet for Donor and Recipient in Refractory Colitis
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: OTHER: Fecal transplantation|OTHER: Unique novel Diet for UC and Unique novel Diet for the donor + FMT|OTHER: Unique novel Diet for UC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: the Effect of Dexmedetomidine and Magnesium Sulfate in Open Resection of Pheochromocytoma
Status: COMPLETED
Conditions: Pheochromocytoma
Interventions: DRUG: Dexmedetomidine|DRUG: General anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Green Banana Peel Extract for Melasma Treatment
Status: COMPLETED
Conditions: Melasma
Interventions: BIOLOGICAL: SPF 30 sunscreen plus pharmaceutical formulation without green banana peel extract|BIOLOGICAL: SPF 30 sunscreen and pharmaceutical formulation containing green banana peel extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Valsartan/Hydrochlorothiazide Combination in Hypertensive Patients Not Controlled With Valsartan Alone
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan plus hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AMT-RegeneraActiva in the Management of Knee Osteoarthritis (OA)
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DEVICE: AMT-Regenera activa|DEVICE: Hyalubrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improve Outcomes for Older Allogeneic Transplant Recipients
Status: RECRUITING
Conditions: Allogeneic Transplantation
Interventions: BEHAVIORAL: Exercise Program (Cohort A Prehab)|BEHAVIORAL: Exercise Program (Cohort B Rehab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed Loop From Onset in Type 1 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus|Type 1 Diabetes
Interventions: DEVICE: Closed-loop system (Florence M or CamAPS FX)|OTHER: Multiple Daily Injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Impact of Exercise on Stress, Fatigue, and Quality of Life in Individuals With Primary Immunodeficiency Disease
Status: COMPLETED
Conditions: Primary Immune Deficiency Disorder|Common Variable Immunodeficiency|Specific Antibody Deficiency|Hypergammaglobulinemia
Interventions: OTHER: Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: IMVAMUNE (MVA-BN)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nasolabial Soft Tissue Esthetics and Maxillary Changes in Unilateral Cleft Lip and Palate Using PreSurgical Infant Orthopedics With Different Approaches
Status: NOT_YET_RECRUITING
Conditions: Unilateral Cleft Lip|Nasoalveolar Molding
Interventions: DEVICE: Naso Alveolar Mold|DEVICE: Taping with nasal elevator:
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three Anaesthesic Method in Electroconvulsive Theraphy
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Propofol|DRUG: Remifentanil and propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study
Status: COMPLETED
Conditions: Human African Trypanosomiasis (HAT)
Interventions: DRUG: fexinidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cathodal tDCS in MCI: A Randomized, Double-Blind, Sham-Controlled Pilot Study
Status: COMPLETED
Conditions: Mild Cognitive Impairment|Cognitive Impairment|Neurocognitive Dysfunction
Interventions: DEVICE: Soterix Medical 1x1 Low Intensity Transcranial Electrical Stimulator (tES) Model 2001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
Status: TERMINATED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Armodafinil|DRUG: Armodafinil|DRUG: Armodafinil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Brief Intervention for Cannabis Use
Status: NOT_YET_RECRUITING
Conditions: Cannabis Use Disorder
Interventions: BEHAVIORAL: Health Education (HealthEdu)|BEHAVIORAL: Values in Action (VIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Involved Field Irradiation (IFI) Versus Elective Nodal Irradiation (ENI) for Esophageal Cancer
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: RADIATION: Involved Field Irradiation(IFI)|DRUG: docetaxel and cisplatin|RADIATION: Elective Nodal Irradiation (ENI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Caffeine Effects on Cardiac Autonomic and Cardiorespiratory Parameters Responses After Aerobic Exercise
Status: UNKNOWN
Conditions: Autonomic Nervous System|Cardiorespiratory Parameters
Interventions: DRUG: Caffeine|DRUG: Placebo|OTHER: Cardiopulmonary test|OTHER: Treadmill aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Effectiveness of Anal Enlargement by Dilators as a Therapeutic Physical Tool in Acute Anal Fissure
Status: UNKNOWN
Conditions: Acute Anal Fissure
Interventions: DEVICE: Anal dilators|PROCEDURE: lateral internal sphincterotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition and Metabolic Prehabilitation in HSCT Patients UK and ROI. BSBMT Multi-centre Survey.
Status: COMPLETED
Conditions: Haematological Malignancy|Bone Marrow Transplant Complications|Stem Cell Transplant Complications|Nutrition Aspect of Cancer|Nutritional and Metabolic Disease|Exercise Interventions|Prehabilitation
Interventions: OTHER: Non validated Survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Soft Tissue Techniques on Hamstring Flexibility Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Graston technique group|OTHER: Active release technique group|OTHER: Proprioceptive Neuromuscular Facilitation stretching group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence of Telmisartan Film-coated Tablet Compared With the Conventional Telmisartan Tablet Following Oral Administration in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Telmisartan film coated tablet|DRUG: Telmisartan conventional tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: Epacadostat|DRUG: Placebo|DRUG: ipilimumab|DRUG: ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Enhancing Medical Compliance and Health-related Quality of Life of Patients With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: BEHAVIORAL: Community support group|OTHER: Printed material Supported
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension
Status: COMPLETED
Conditions: Hypertension,Essential
Interventions: OTHER: Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Nebulized Budesonide and Intranasal Budesonide Spray in Children With Adenotonsillar Hypertrophy
Status: UNKNOWN
Conditions: Snoring|Mouth Breathing
Interventions: DRUG: Nebulized Budesonide|DRUG: Intranasal Budesonide Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Sequential Administration of Two Gemcitabine Combinations in Operable Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: gemcitabine|DRUG: doxorubicin|DRUG: cisplatin|PROCEDURE: surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Function After Knee Arthroplasty With Weight-Bearing Biofeedback
Status: COMPLETED
Conditions: Arthropathy of Knee Joint
Interventions: OTHER: Weight-bearing biofeedback exercise|OTHER: Standard of care exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Conversational Agent (Cecebot) to Improve Insomnia in Stage I-III Breast Cancer Survivors
Status: RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Insomnia
Interventions: BEHAVIORAL: Cognitive Behavior Therapy for Insomnia|OTHER: Internet-Based Intervention|OTHER: Medical Device Usage and Evaluation|OTHER: Questionnaire Administration|OTHER: Text Message-Based Navigation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Behavioral Therapy for Insomnia to Address Insomnia Symptoms in People With Multiple Sclerosis
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy for Insomnia|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Elective Treatment Rates and Surgical Non-eligibility Among Men and Women With Intact Abdominal Aortic Aneurysms
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm|Abdominal Aortic Aneurysm Without Rupture|Aneurysm|Aortic Aneurysm|Aneurysm Abdominal
Interventions: PROCEDURE: Elective surgery for intact AAA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer
Status: RECRUITING
Conditions: Metastatic Pancreatic Carcinoma|Stage II Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer|Unresectable Pancreatic Carcinoma
Interventions: DRUG: Hydroxychloroquine|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of HIV-MAG Vaccine +/- IL-12 and Ad35-GRIN/ENV in HIV-uninfected Volunteers
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIV-MAG (3,000mcg)|BIOLOGICAL: GENEVAX® IL-12 (100mcg)|BIOLOGICAL: GENEVAX® IL-12 (1000mcg)|BIOLOGICAL: Ad35-GRIN/ENV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Armodafinil in Binge Eating Disorder (BED)
Status: COMPLETED
Conditions: Binge Eating Disorder|Overweight|Obese
Interventions: DRUG: Armodafinil|DRUG: Armodafinil|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TRIple in Asthma hiGh strenGth vErsus Ics/Laba hs and tiotRopium (TRIGGER)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: CHF 5993 200/6/12.5 µg|DRUG: CHF 1535 200/6 µg|DRUG: CHF 1535 200/6 µg + Tiotropium Respimat 2.5 µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of PCAR-019 in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma
Status: UNKNOWN
Conditions: Acute Lymphocytic Leukemia|Chronic Lymphocytic Leukemia|Follicular Lymphoma|Mantle Cell Lymphoma|B-cell Prolymphocytic Leukemia|Diffuse Large Cell Lymphoma
Interventions: BIOLOGICAL: PCAR-019 (anti-CD19 CAR-T cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral Administration of AZD8329
Status: COMPLETED
Conditions: Overweight|Healthy|Male
Interventions: DRUG: AZD8329|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sorafenib in Myelodysplastic Syndrome
Status: TERMINATED
Conditions: Myelodysplastic Syndromes|Leukemia, Myelomonocytic, Chronic
Interventions: DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia
Status: COMPLETED
Conditions: Immunosuppresion|Thrombocytopenia|Pancytopenia|Neutropenia
Interventions: BIOLOGICAL: Anti-thymocyte globulin (rabbit)|BIOLOGICAL: Anti-thymocyte globulin (horse)|DRUG: Cyclosporine|DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Physical Activity in Individuals With Post-bariatric Hypoglycemia
Status: COMPLETED
Conditions: Hypoglycemia|Roux-en-Y Gastric Bypass|Post-bariatric Hypoglycemia|Physical Activity
Interventions: BEHAVIORAL: Physical activity (cycling on a stationary bicycle ergometer or walking on a treadmill)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of JNJ-87189401 Plus JNJ-78278343 for Advanced Prostate Cancer
Status: RECRUITING
Conditions: Advanced Prostate Cancer
Interventions: DRUG: JNJ-78278343|DRUG: JNJ-87189401
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Poziotinib in Patients With HER2+ Recurrent Stage IV BC Who Have Received at Least 2 Prior HER2-directed Regimens
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: NOV120101 (Poziotinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Upstream Treatment With High Intensity Statin on the Outcomes of STMI Patients Treated With PPCI
Status: UNKNOWN
Conditions: ST Elevation Myocardial Infarction
Interventions: DRUG: Atorvastatin|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Treatment With ORACEA® for Geographic Atrophy (TOGA)
Status: COMPLETED
Conditions: Geographic Atrophy
Interventions: DRUG: ORACEA®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Reading Fairy Tales and Coloring on Children's Fear Level in Children Who Are Administered Inhaler Medication With a Mask.
Status: COMPLETED
Conditions: Fear Anxiety|Satisfaction
Interventions: DEVICE: reading fairy tales|DEVICE: painting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DRUG: Intravenous (IV) citrulline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Failure
Status: COMPLETED
Conditions: Heart Failure, Congestive
Interventions: DRUG: Eplerenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Safe and Healthy Schools
Status: COMPLETED
Conditions: Sars-CoV-2 Infection|COVID-19
Interventions: DIAGNOSTIC_TEST: BinaxNOW Test|DIAGNOSTIC_TEST: "Lollipop" swab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of DTaP-HB-PRP~T Combined Vaccine to Tritanrix-HepB/Hib™, Both Given Concomitantly With Oral Polio Vaccine
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Pertussis|Hepatitis B|Haemophilus Infections
Interventions: BIOLOGICAL: DTaP-HB-PRP~T vaccine + OPV|BIOLOGICAL: Tritanrix-HepB/Hib™ + OPV vaccine|BIOLOGICAL: Oral Polio Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION