pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Type 2 Diabetes Haptoglobin Phenotype and Vitamin E
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Vitamin E (d-alpha-tocopheryl acetate)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation
Status: RECRUITING
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: Catheter ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Evaluation for Hybrid Cardiac Procedures
Status: RECRUITING
Conditions: Left Main Coronary Artery Disease|Left Anterior Descending Coronary Artery Stenosis|Valve Disease, Heart|Carotid Stenosis|Coronary Artery Disease|Heart Diseases|Heart Valve Diseases|Carotid Occlusion
Interventions: PROCEDURE: Coronary artery bypass grafting|PROCEDURE: Percutaneous coronary intervention|PROCEDURE: Surgical valve replacement|PROCEDURE: Carotid artery stenting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Status: UNKNOWN
Conditions: Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Interventions: DIAGNOSTIC_TEST: Brain MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibitors (ICI) in Metastatic Renal Cell Carcinoma
Status: RECRUITING
Conditions: Renal Cell Carcinoma|Metastatic Renal Cell Carcinoma|Oligoprogressive|Progression
Interventions: RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of ABT-450/r - Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C -An Observational Study in Ireland
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Ombitasvir/paritaprevir/ritonavir|DRUG: Dasabuvir|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Malaria Candidate Vaccines FP9 Circumsporozoite (CS) and MVA CS in Adult Gambian Men
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: FP9 CS|BIOLOGICAL: MVA CS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Music Therapy in Patients With Breast Cancer- a Randomized Controlled Trial
Status: WITHDRAWN
Conditions: Music Therapy, Breast Cancer, Anxiety, Fatigue
Interventions: OTHER: music|OTHER: comprehensive in-patient education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Rituximab Plus High-Dose Chemotherapy Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin's
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability and Pharmacokinetics of BI 135585 XX Administered as Tablet With and Without Food
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 135585|DRUG: BI 135585
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Pharmacodynamic Effects of MTR107 in End-Stage Renal Disease (ESRD) Patients
Status: UNKNOWN
Conditions: Hypotension|End Stage Renal Disease|Intra Dialytic Hypotension
Interventions: DRUG: MTR107
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Dexmedetomidine Premedication
Status: COMPLETED
Conditions: Benign Neoplasm of Vocal Fold - Glottis
Interventions: DRUG: Dexmedetomidine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microbiological Evaluation and Clinical 24-month Follow-up of Adhesive Systems on Carious Dentin
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: Applications of self-etching adhesives and dental restorations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment of Aortic Stenosis With a Next Generation Surgical Aortic Valve
Status: COMPLETED
Conditions: Aortic Valve Stenosis With Insufficiency|Aortic Valve Stenosis
Interventions: DEVICE: Aortic Valve Replacement with EDWARDS INTUITY Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Plating Versus Nailing in Pediatric BB Forearm Fractures
Status: ENROLLING_BY_INVITATION
Conditions: Intramedullary Nail|Plate Fixation|Forearm Fracture|Randomized Controlled Trial
Interventions: DEVICE: Dual intramedullary nailing|DEVICE: Dual plating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Community-based Group Rehabilitation Program for Dynamic Balance and Mobility Post Stroke
Status: COMPLETED
Conditions: Sequelae of Stroke
Interventions: BEHAVIORAL: conventional physical therapy|BEHAVIORAL: community-based group rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Immunogenicity of a New Influenza Vaccine Candidate MVA-NP+M1 in Healthy Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: MVA-NP+M1|BIOLOGICAL: MVA-NP+M1|BIOLOGICAL: MVA-NP+M1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Reactogenicity Following a Booster Dose of COVID-19 mRNA Vaccine (Pfizer-BioNtech) and Two Adjuvanted Sub-unit Vaccines (SP/GSK) Administered in Adults Who Received 2 Doses of Pfizer-BioNTech mRNA Vaccine as a Primary Vaccination
Status: UNKNOWN
Conditions: COVID-19|Vaccine Reaction
Interventions: BIOLOGICAL: BNT162b2|BIOLOGICAL: CoV2 preS dTM adjuvanted vaccine (D614), Sanofi/GSK|BIOLOGICAL: CoV2 preS dTM adjuvanted vaccine (B.1.351), Sanofi/GSK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pre-exposure Prophylaxis (PrEP) for People Who Inject Drugs (PWID)
Status: WITHDRAWN
Conditions: Intravenous Drug Abuse
Interventions: BEHAVIORAL: PrEP uptake/adherence intervention|BEHAVIORAL: Harm reduction standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization
Status: COMPLETED
Conditions: Aspirin Sensitivity
Interventions: DRUG: Omalizumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Tissue Plasminogen Activator (tPA) Treatment for an Atypical Acute Respiratory Distress Syndrome (COVID-19)
Status: WITHDRAWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Tissue plasminogen activator|DRUG: Ringer solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of Pelubiprofen & Loxoprofen in Patients With Upper Respiratory Tract Infection
Status: COMPLETED
Conditions: Acute Upper Respiratory Infection|Fever
Interventions: DRUG: Pelubiprofen|DRUG: Loxoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: INFLIXIMAB|DRUG: AZATHIOPRINE|DRUG: MERCAPTOPURINE|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Olanzapine/Fluoxetine Combination Versus Comparator in the Treatment of Bipolar I Depression
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Olanzapine|DRUG: Fluoxetine|DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Ultrasound-guided Radiofrequency Ablation in the Treatment of Refractory Hyperthyroidism
Status: ACTIVE_NOT_RECRUITING
Conditions: Hyperthyroidism/Thyrotoxicosis
Interventions: PROCEDURE: Ablation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oncolytic Adenovirus-Mediated Gene Therapy for Lung Cancer
Status: WITHDRAWN
Conditions: Non-small Cell Lung Cancer Stage I
Interventions: BIOLOGICAL: Ad5-yCD/mutTKSR39rep-ADP Adenovirus
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategies to Control Robotic Hand Prosthesis Via HD-sEMG and to Restore Sensory Feedback Via TENS
Status: RECRUITING
Conditions: Upper Limb Amputees
Interventions: OTHER: Electromyography recording with HD-sEMG|OTHER: Transcutaneous Electrical Nerve Stimulation (TENS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: BFR After Biceps Tendon Repair and MPFLR
Status: NOT_YET_RECRUITING
Conditions: Patellofemoral Joint Dislocation|Bicep Tendon Rupture
Interventions: OTHER: Blood Flow Restriction (BFR) Therapy|OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tailored Lifestyle Intervention in Obese Adults Within Primary Care Practice - Choose to Lose
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Intervention|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Nursing Process on the Quality of Life of the Patient With Definitive Pacemaker Implantation
Status: COMPLETED
Conditions: Quality of Life
Interventions: OTHER: Educational|OTHER: Maneuver control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Analgesic Efficacy of Transversus Abdominis Plane Block After Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Laparoscopic Cholecystectomy
Interventions: PROCEDURE: transversus abdominis plane block|PROCEDURE: TAP block placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Time-Restricted Feeding in Children and Adolescents With Obesity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Childhood|Obesity, Adolescent
Interventions: BEHAVIORAL: Lifestyle intervention|BEHAVIORAL: TRF intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study to Evaluate the Efficacy, Safety and PK of Intravenous Single Injection LC28-0126 Immediately Before PCI in STEMI Patients
Status: COMPLETED
Conditions: ST-segment Elevation Myocardial Infarction
Interventions: DRUG: Placebo|DRUG: LC28-0126 Dose A|DRUG: LC28-0126 Dose B|DRUG: LC28-0126 Dose C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety of Co-administration of GSK Biologicals' Poliorix and Infanrix in Healthy Children in Russia
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Poliorix TM|BIOLOGICAL: Infanrix TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: INS19 CAR-T Cells for the Treatment of Relapsed or Refractory Acute B Lymphoblastic Leukemia
Status: NOT_YET_RECRUITING
Conditions: Leukemia, B-cell
Interventions: BIOLOGICAL: INS19 CAR-T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Levetiracetam in the Inpatient Treatment of Alcohol Withdrawal Syndrome
Status: COMPLETED
Conditions: Alcohol Withdrawal Syndrome
Interventions: DRUG: Levetiracetam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma
Status: SUSPENDED
Conditions: Locally Advanced Extraskeletal Myxoid Chondrosarcoma|Locally Advanced Leiomyosarcoma|Locally Advanced Liposarcoma|Locally Advanced Undifferentiated Pleomorphic Sarcoma|Locally Advanced Unresectable Soft Tissue Sarcoma|Metastatic Undifferentiated Pleomorphic Sarcoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib|PROCEDURE: Computed Tomography|BIOLOGICAL: Ipilimumab|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Food and Beverage Labels and Vending Machine Selections
Status: COMPLETED
Conditions: Food Preferences|Obesity|Weight Gain
Interventions: BEHAVIORAL: Exposure to calorie information|BEHAVIORAL: Exposure to healthy labels only|BEHAVIORAL: Exposure to healthiness information|BEHAVIORAL: Exposure to physical activity equivalents|BEHAVIORAL: Exposure to "high in" nutrient warning labels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Tirelizumab Plus Chemotherapy Versus Chemotherapy Alone in Patients With Lymph Node Positive Gastric Cancer After Surgery
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: tirelizumab|DRUG: chemotherapy with oxaliplatin + heroda
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nivolumab With or Without Ipilimumab in Advanced Metastatic Cancer
Status: COMPLETED
Conditions: Advanced Metastatic Cancer|Advanced Prostate Cancer
Interventions: BIOLOGICAL: Nivolumab Monotherapy|BIOLOGICAL: Nivolumab and Ipilimumab and Combination for Metastatic Cancer|BIOLOGICAL: Nivolumab and Ipilimumab (3 mg/kg) Combination for Prostate Cancer|BIOLOGICAL: Nivolumab and Ipilimumab (5 mg/kg) Combination for Prostate Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab and Trabectedin +/- Carboplatin in Advanced Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Epithelial Cancer Recurrent
Interventions: DRUG: bevacizumab and trabectedin|DRUG: bevacizumab, trabectedin and carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment
Status: RECRUITING
Conditions: Smoking Cessation|Cancer, Treatment-Related
Interventions: DRUG: Varenicline|DRUG: Bupropion|DRUG: Long-acting nicotine replacement therapy|BEHAVIORAL: Low-intensity counseling|BEHAVIORAL: High-intensity counseling|OTHER: No nicotine replacement therapy|DRUG: Nicotine Replacement Products
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Treating Patients With Stage IB-IV Mycosis Fungoides
Status: ACTIVE_NOT_RECRUITING
Conditions: Mycosis Fungoides|Sezary Syndrome|Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IIB Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage III Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IIIA Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IVA1 Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IVA2 Mycosis Fungoides and Sezary Syndrome AJCC v8|Stage IVB Mycosis Fungoides and Sezary Syndrome AJCC v8
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Paracetamol in Reducing Pain During Ophthalmological Examination for Retinopathy of Prematurity: a Prospective Randomised Trial
Status: UNKNOWN
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Paracetamol|DRUG: Topical anaesthetic drop with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies
Status: COMPLETED
Conditions: Relapsed or Refractory Lymphoproliferative Malignancies|Hodgkin's Lymphoma|Peripheral T-cell Lymphoma|B-cell Lymphoma|Waldenstrom's Macroglobulinemia
Interventions: DRUG: Pralatrexate Injection|DRUG: Gemcitabine Hydrochloride|DIETARY_SUPPLEMENT: Vitamin B12|DIETARY_SUPPLEMENT: Folic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare a Hemostatic Powder TC-325 and Standard Treatment in the Control of Acute Upper Gastrointestinal Bleeding From Nonvariceal Causes
Status: COMPLETED
Conditions: Acute Upper Gastrointestinal Bleeding
Interventions: DEVICE: Endoscopic Application of a Hemostatic Powder TC-325|DEVICE: Hemo-clipping|DRUG: Epinephrine|DEVICE: thermo-coagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial in Liver Transplant Recipients Treated in Steroid Sparing Regimen
Status: COMPLETED
Conditions: Chronic Hepatitis C|Organ Transplantation|Immunosuppression
Interventions: DRUG: Neoral|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Shock Wave Therapy for Lateral Hip Pain, Caused by Tendon Pathology
Status: COMPLETED
Conditions: Tendinopathy
Interventions: PROCEDURE: focused shock wave therapy|PROCEDURE: ultrasound therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Vitamin D Supplementation on Recurrent Respiratory Infections in Paediatric Primary Care.
Status: COMPLETED
Conditions: Recurrent Respiratory Tract Infections
Interventions: DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia
Status: COMPLETED
Conditions: Progressive Keratoconus|Corneal Ectasia
Interventions: PROCEDURE: Corneal collagen|PROCEDURE: Sham comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FLOT vs. FLOT/Ramucirumab for Perioperative Therapy of Gastric or GEJ Cancer (RAMSES)
Status: COMPLETED
Conditions: Stomach Cancer|Gastroesophageal Junction Cancer
Interventions: DRUG: Docetaxel|DRUG: Oxaliplatin|DRUG: Calciumfolinat|DRUG: 5-Fluorouracil|BIOLOGICAL: Ramucirumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Home-Based Exercise Program for Strength Training in Endometrial Cancer Survivors in Rural Areas
Status: RECRUITING
Conditions: FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma|FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma|Stage IA Uterine Corpus Cancer AJCC v8|Stage IB Uterine Corpus Cancer AJCC v8
Interventions: OTHER: Exercise Counseling|OTHER: Exercise Intervention|OTHER: Health Promotion and Education|OTHER: Interview|OTHER: Physical Performance Testing|OTHER: Questionnaire Administration|OTHER: Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
Status: RECRUITING
Conditions: Advanced Solid Tumor Historically Known for High EphA2 Expression|Urothelial Cancer|Ovarian Cancer|Non-small Cell Lung Cancer|Head and Neck Cancer|Triple Negative Breast Cancer|Gastric/Upper Gastrointestinal Cancer
Interventions: DRUG: BT5528|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NovoLog vs. Humalog in Insulin Pumps in Children and Adolescents
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin lispro|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Nitrofurantoin and Calcium Hydroxide as Intracanal Medicaments in Alleviating Post-operative Pain
Status: COMPLETED
Conditions: Pain, Postoperative|Irreversible Pulpitis
Interventions: DRUG: Nitrofurantoin 100 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Methylxanthine Intake and Blue Light Exposure on Adhesive Shoulder Capsulitis.
Status: NOT_YET_RECRUITING
Conditions: Adhesive Capsulitis of Shoulder
Interventions: OTHER: Physiotherapy treatment.|OTHER: Physiotherapy treatment and modification of the biorhythm.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: HIDIT II - PegIFN-alfa2a Plus Tenofovir in Chronic Delta Hepatitis
Status: COMPLETED
Conditions: Hepatitis D
Interventions: DRUG: PEG-IFN alfa-2a, Tenofovir|DRUG: PEG-IFN alfa-2a, placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: BRCA1 Gene Mutation|BRCA2 Gene Mutation|Folate Receptor Alpha Positive|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Uterine Corpus Carcinoma|Recurrent Uterine Serous Carcinoma|Recurrent Uterine Carcinosarcoma|Platinum Resistant Ovarian Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Mirvetuximab Soravtansine|OTHER: Pharmacokinetic Study|DRUG: Rucaparib Camsylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybridized Three Steps Intervention to Prevent Diabetes in Venezuela
Status: COMPLETED
Conditions: Obesity|Overweight|PreDiabetes|Diabetes Mellitus, Type 2|Risk Factor, Cardiovascular
Interventions: BEHAVIORAL: Total Diet Replacement (TDR)|BEHAVIORAL: Medical Nutritional Therapy (MNT)|BEHAVIORAL: Diabetes Prevention Program 4 months|BEHAVIORAL: Diabetes Prevention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery
Status: RECRUITING
Conditions: Opioid Use, Unspecified|Pain, Postoperative
Interventions: DEVICE: Nociception Level monitor (NOL)|DEVICE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19)
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Coronavirus Infection
Interventions: DRUG: vadadustat|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allium Extracts on the Incidence of Respiratory Infection Symptoms in Healthy Elderly Volunteers
Status: COMPLETED
Conditions: Immunity
Interventions: DIETARY_SUPPLEMENT: Garlic and onion concentrate|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of hzVSF-v13 in Patients With COVID-19 Pneumonia
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: hzVSF-v13|DRUG: Placebo (Normal saline solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Peritoneal Cancer
Status: UNKNOWN
Conditions: Malignant Mesothelioma
Interventions: BIOLOGICAL: recombinant interferon gamma|DRUG: cisplatin|DRUG: doxorubicin hydrochloride|DRUG: gemcitabine hydrochloride|DRUG: mitomycin C|PROCEDURE: conventional surgery|PROCEDURE: hyperthermia treatment|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Cerebellar tACS-iTBS in Ataxia
Status: NOT_YET_RECRUITING
Conditions: Ataxia
Interventions: DEVICE: Real (real iTBS/tACS + exergaming)|DEVICE: Sham (sham iTBS/tACS + exergaming)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Moderate to Severe Plaque Psoriasis of the Scalp
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Apremilast|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3154207 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: LY3154207|DRUG: Placebo|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Consequences of Hypoglycaemia on Cardiovascular and Inflammatory Responses
Status: COMPLETED
Conditions: Hypoglycemia|Inflammatory Response|Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: PROCEDURE: hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Magnetic Resonance Imaging (MRI) to Assess Radial Artery Compression and Arterial Perfusion While TR Band is Applied
Status: COMPLETED
Conditions: Poor Peripheral Perfusion
Interventions: DEVICE: TR Band
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Relative Bioavailability of Ibuprofen From a Single Fixed Dose Combination Tablet of Ibuprofen and Caffeine Compared to Single Tablets of Ibuprofen and Ibuprofen Lysinate
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibuprofen+caffeine FDC|DRUG: Ibuprofen (Nurofen Immedia®)|DRUG: Ibuprofen (Brufen®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mesothelioma
Interventions: DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination in Adults With Chronic HCV and HBV Coinfection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: LDV/SOF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nortriptyline for the Treatment of Functional Dyspepsia
Status: UNKNOWN
Conditions: Functional Dyspepsia
Interventions: DRUG: Nortriptyline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-6213 Co-Administered With Atorvastatin in Participants With Hypercholesterolemia (MK-6213-006)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK-6213|DRUG: Atorvastatin calcium|DRUG: Placebo for MK-6312 160 mg|DRUG: Placebo for Atorvastatin 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque
Status: COMPLETED
Conditions: Gingivitis|Plaque
Interventions: OTHER: Colgate® Cavity Protection Toothpaste|OTHER: Listerine® Cool Mint®|OTHER: Concept Curve Winter Series Toothbrush|OTHER: 5% Hydroalcohol Mouthrinse|OTHER: Mouthrinse Prototype 1|OTHER: Mouthrinse Prototype 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prenatal US Assessment of Superior Mesenteric Vessels for Digestive Rotation
Status: COMPLETED
Conditions: Singleton-Merten Syndrome|Postnatal Complication
Interventions: OTHER: Ultrasound exam|OTHER: Postnatal abdominal ultrasound|OTHER: Pediatric Follow up
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Infant Formula Supplemented With Probiotic Microorganisms and/or Prebiotic.
Status: UNKNOWN
Conditions: Focus on Healthy Infant Growth.
Interventions: DIETARY_SUPPLEMENT: Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Bioequivalence of Generic Tiotropium Bromide Inhalation Powder and Reference Product in Healthy Adult Participants Under Fasting Conditions (Pilot)
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Tiotropium Bromide Inhalation Powder|DRUG: Spiriva HandiHaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety and Tolerability as Well as Absorption and Excretion of TC-5214 in Medically Stable Elderly Subjects
Status: COMPLETED
Conditions: Elderly Subjects 65 Years and Older, Healthy or With a Stable Disease and Treatment.
Interventions: DRUG: TC-5214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of Botulinum Toxin vs. Corticosteroid for the Treatment of Refractory Plantar Fasciitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Plantar Fasciitis
Interventions: DRUG: Botulinum Toxin A|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: OA Optimization Program Pilot Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteo Arthritis Knee|Osteoarthritis, Knee|Osteoarthritis, Hip|Osteoarthritis
Interventions: BEHAVIORAL: Alberta Healthy Living Program|BEHAVIORAL: Alberta Obesity Centre Program|BEHAVIORAL: Osteoarthritis advice|BEHAVIORAL: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors
Status: TERMINATED
Conditions: Recurrent Childhood Medulloblastoma|Recurrent Childhood Ependymoma|Childhood Atypical Teratoid/Rhabdoid Tumor|Embryonal Tumor With Abundant Neuropil and True Rosettes|Metastatic Malignant Neoplasm to the Leptomeninges
Interventions: DRUG: Intra thecal methotrexate|DRUG: topotecan|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Pertuzumab in Combination With Tocilizumab in Subjects With Metastatic HER2 Positive Breast Cancer Resistant to Trastuzumab
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Ability of GSK706769 to Maintain Clinical Remission After Withdrawal of Enbrel in Rheumatoid Arthritis Patients
Status: WITHDRAWN
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: GSK706769|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy.
Status: COMPLETED
Conditions: Acute-On-Chronic Liver Failure
Interventions: DRUG: Lactulose + Rifaximin|DRUG: Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dendritic Cell Immunotherapy Against Cancer Stem Cells in Glioblastoma Patients Receiving Standard Therapy
Status: RECRUITING
Conditions: Glioblastoma
Interventions: BIOLOGICAL: Dendritic cell immunization|DRUG: Adjuvant temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Lersivirine (UK-453,061) On Qt Intervals In Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Lersivirine|DRUG: Placebo|DRUG: Lersivirine (if necessary)|DRUG: Lersivirine|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dinaciclib and Akt Inhibitor MK2206 in Treating Patients With Pancreatic Cancer That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Unresectable Pancreatic Carcinoma
Interventions: DRUG: Akt Inhibitor MK2206|DRUG: Dinaciclib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotinamide Riboside and Mitochondrial Biogenesis
Status: COMPLETED
Conditions: Mitochondrial Diseases|Mitochondrial Myopathies|Progressive External Ophthalmoplegia|Progressive Ophthalmoplegia|Progressive; Ophthalmoplegia, External|Mitochondria DNA Deletion|MELAS
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers
Status: TERMINATED
Conditions: Nicotine Dependence|ADHD
Interventions: OTHER: Very low nicotine content cigarettes|OTHER: Conventional nicotine content cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Validation of Efficacy of Oral Administration of the Food Additive Colostrum Derived Anti Clostridium Difficile Antibodies
Status: WITHDRAWN
Conditions: Clostridium Difficile-Associated Diarrhea
Interventions: DRUG: Colostrum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Chinese Traditional Medicine for Post Revascularization Treatment of Coronary Artery Disease
Status: COMPLETED
Conditions: Percutaneous Coronary Artery Intervention|Coronary Artery Bypass Graft|Acute Coronary Syndrome
Interventions: DRUG: cipher prescription 1|DRUG: cipher prescription 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis
Status: COMPLETED
Conditions: Onychomycosis
Interventions: DRUG: Efinaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Posttraumatic Swelling and Pain With Zhi Kang Capsule
Status: UNKNOWN
Conditions: Soft Tissue Injuries
Interventions: DRUG: Zhi Kang Capsule|DRUG: Simulant agent for Zhi Kang Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: HFN Versus NIV in Cystic Fibrosis. The HIFEN Study
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DEVICE: High flow nasal oxygen cannula|DEVICE: Noninvasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of the C0-C1 Mobilization Technique in Patients With Chronic Neck Pain
Status: UNKNOWN
Conditions: Musculoskeletal Manipulations|Cervical Pain
Interventions: OTHER: Intervention Group|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ketamine Added to Local Anesthetic in Modified Pectoral Block for Management of Postoperative Pain
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: modified pectoral block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: In-use Study of Four Different Tampons
Status: COMPLETED
Conditions: Menstruation
Interventions: DEVICE: tampon D|DEVICE: tampon M|DEVICE: tampon T|DEVICE: tampon V
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Phase II Trial to Evaluate CD34+ Cells Mobilization and Collection in Patients With Fanconi Anemia for Subsequent Transduction With a Lentiviral Vector Carring FANCA Gene. FANCOSTEM-1
Status: COMPLETED
Conditions: Fanconi Anemia
Interventions: DRUG: filgrastim|DRUG: plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Hydroxychloroquine In Covid-19 Kinetics
Status: TERMINATED
Conditions: Covid 19|Corona Virus Infection
Interventions: DRUG: Hydroxychloroquine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Promoting Organ Donor Registration in Family Physician Offices
Status: COMPLETED
Conditions: Organ Donation|Registration for Deceased Organ Donation
Interventions: BEHAVIORAL: Reception staff providing handout.|BEHAVIORAL: Mobile Tablet (e.g. iPad)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Modulation of Gut Microbiota in Early Sepsis: A Pilot Study
Status: COMPLETED
Conditions: Sepsis
Interventions: DIETARY_SUPPLEMENT: Winclove 607|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Mucosal Immunity of Ulcerative Colitis Patients Undergoing Therapy With Trichuris Suis Ova
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Trichuris suis ova
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Whey Protein Consumed as a Pre-meal on Postprandial Lipemia in Healthy and Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Healthy|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: 20 g whey protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Measurement of PD-L1 Levels With Positron Emission Tomography (PET) in Head and Neck Malignancies and Intracranial Metastases
Status: TERMINATED
Conditions: Cancer Head Neck|Metastatic Cancer|Metastatic Lung Cancer
Interventions: DRUG: adnectin 18F-BMS-986192 Head and Neck Cancer|DRUG: adnectin 18F-BMS-986192 Brain Metastases
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess Efficacy/Safety of Ladarixin in Type 1 Diabetes Patients With Preserved ß-cell Function at Baseline.
Status: TERMINATED
Conditions: New-onset Type 1 Diabetes
Interventions: DRUG: Ladarixin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Study of the Efficacy of Hypnosis Versus Relaxation and Control in Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: BEHAVIORAL: Hypnosis sessions|BEHAVIORAL: Relaxation group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nordic Walking and Free Walking on Arm Swing Parameters and Gait in Parkinson's Disease
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Interventions: OTHER: Nordic walking training|OTHER: Free Walking training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Tinnitus With Noninvasive Neuromodulation and Listening Therapy
Status: NOT_YET_RECRUITING
Conditions: Tinnitus, Subjective|Hyperacusis|Hearing Disorders
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)|DEVICE: Sham TDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fecal Microbiota Transplantation in Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: FMT capsules|DIETARY_SUPPLEMENT: FMT placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Pemetrexed and Cyclophosphamide Given Every 21 Days in Advanced Breast Cancer Patients
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: pemetrexed|DRUG: cyclophosphamide|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Preservative-free Prostaglandin Eye Drops in Sign and Symptoms on the Eyes of Patients With Glaucoma
Status: COMPLETED
Conditions: Ocular Hypertension|Open-Angle Glaucoma
Interventions: DRUG: Tafluprost 0.0015%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT