pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bortezomib and Gemcitabine in Treating Patients With Relapsed Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: bortezomib|DRUG: gemcitabine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulodexide in the Treatment of Chronic Primary Venous Disease of the Lower Extremities
Status: RECRUITING
Conditions: Chronic Venous Disease|Chronic Insufficiency Venous
Interventions: DRUG: Vessel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of a Probiotic Product on Acute Upper Respiratory Tract Infections (Common Cold) in Healthy Children
Status: COMPLETED
Conditions: Acute Upper Respiratory Tract Infections (Common Cold)
Interventions: DIETARY_SUPPLEMENT: Probi Defendum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (P08683, MK-8457-008)
Status: TERMINATED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: MK-8457 100 mg|DRUG: Dose-Matched Placebo|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Cordcare for Reduction in Neonatal Mortality and Omphalitis
Status: COMPLETED
Conditions: Neonatal Mortality|Cord Care|Omphalitis
Interventions: DRUG: Chlorhexidine 4%|DRUG: Chlorhexidine 4%|OTHER: Control cord cleaning solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity Study of Tdap Vaccinations for Plasma Donors
Status: ACTIVE_NOT_RECRUITING
Conditions: Tetanus, Diphtheria and Acellular Pertussis Vaccination
Interventions: BIOLOGICAL: Tdap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Coagulation Disorders Secondary to Two Plasmapheresis Techniques (Double Filtration Plasmapheresis vs. PFS). Descriptive Pilot Study.
Status: NOT_YET_RECRUITING
Conditions: Hyperfibrinogenemia|Hemostatic Disorder
Interventions: PROCEDURE: Single Plasma Exchange followed by Double Filtration Plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Development and Evaluation of a Cancer-Related Fatigue Patient Education Program
Status: UNKNOWN
Conditions: Cancer-Related Fatigue
Interventions: BEHAVIORAL: Fatigue Patient Education Program (FIBS)|BEHAVIORAL: Fatigue Patient Education Program (FIBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Relation betwEen Abdominal Aorta and Carotid Artery Responses to SymPathetic stimulatiON uSing duplEx Ultrasound
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DIAGNOSTIC_TEST: Carotid artery reactivity test (CAR-test)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety of Continued Administration of MDV3100 in Subjects With Prostate Cancer Who Showed Benefit From Prior Exposure to MDV3100
Status: COMPLETED
Conditions: Castration-Resistant Prostate Cancer (CRPC)
Interventions: DRUG: Enzalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -Healthy Volunteers Study
Status: COMPLETED
Conditions: Upper Gastrointestinal Bleeding
Interventions: DEVICE: PillSense System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Hemorrhoids: Options of Traditional Hemorrhoidectomy
Status: NOT_YET_RECRUITING
Conditions: Hemorrhoids|Open Hemorrhoidectomy
Interventions: PROCEDURE: Open hemorrhoidectomy with 'cold' scalpel|PROCEDURE: Open hemorrhoidectomy with electrosurgical scalpel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vascular Surgical Antibiotic Prophylaxis Study (VSAPS 2)
Status: UNKNOWN
Conditions: MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Interventions: DRUG: Antibiotic Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Antiplatelet Effect of Low Doses of Aspirin Taken Every 12 Hours in Patients Undergoing Coronary Artery Bypass Graft and/or Aortic Valve Surgery
Status: UNKNOWN
Conditions: Coronary Arteriosclerosis
Interventions: DRUG: Aspirin|DRUG: Aspirin|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Evaluation of Initial High Risk Human Papillomavirus (HR-HPV) Viral Load as Predictive Marker for Cervical Intraepithelial Neoplasia Grade 1 (CIN1) Persistence
Status: TERMINATED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: A cervico-vaginal cervical smear
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Placebo-controlled, Randomized Clinical Trial to Assess the Safety, Feasibility, and Pharmacokinetics of Microbiota Transplant Therapy With Antibiotic Preconditioning and Fiber Supplementation in Patients With Pulmonary Arterial Hypertension
Status: NOT_YET_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: MTT with antibiotic preconditioning + fiber supplementation|DRUG: MTT with antibiotic preconditioning + placebo supplementation|OTHER: MTT with placebo + placebo supplementation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: High Intensity Aerobic Interval Training With Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: OTHER: HIGH VOLUME (HV) Supervised exercise|OTHER: Mediterranean Diet Recommendations|OTHER: Physical Activity Recommendations|OTHER: LOW VOLUME (LW) Supervised exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Study of Rifamycin SV-MMX® 600 mg Tablets After Single and Multiple t.i.d. Doses in Healthy Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rifamycin SV-MMX® 600
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Transporter Pgp Substrate Digoxin in Advanced Solid Tumor Subjects
Status: COMPLETED
Conditions: Advanced Solid Tumor
Interventions: DRUG: Apatinib Mesylate|DRUG: Digoxin tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Inferiority of Fixed Combination of Beclomethasone Dipropionate (BDP) + Formoterol Fumarate (FF) + Glycopyrronium Bromide (GB) Versus Combination of Fluticasone Furoate (FlF)/Vilanterol (VI) + Tiotropium Bromide in Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: BDP/FF/GB|DRUG: FlF/VI + Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 2|Adverse Event|Blood Pressure|Prehypertension|Cardiovascular Risk Factor
Interventions: DRUG: Allisartan Isoproxil|DRUG: Amlodipine 5mg|OTHER: Standard treatment by current guideline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Losartan and Losartan Plus Isosorbide Mononitrate on Central Blood Pressure Measurements (0954-317)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: losartan potassium|DRUG: Comparator: isosorbide mononitrate (ISMN)|DRUG: Comparator: losartan + ISMN|DRUG: Comparator: losartan + ISMN|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Tyrosine Hydroxylase Antibody Levels in Autoimmune Polyglandular Syndrome Type 1 Associated Keratitis
Status: COMPLETED
Conditions: Autoimmune Polyglandular Syndrome Type I|Autoimmune Keratitis
Interventions: DIAGNOSTIC_TEST: Detection of autoantibodies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Comparative Analysis of Three Locoregional Anesthesia Methods in Breast Tumour Pathology Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Chronic Post Operative Pain|Breast Tumor|Locoregional Anesthesia|Breast Pain
Interventions: PROCEDURE: SIFP Block Locoregional Interfascial Anesthesic Technique|PROCEDURE: PECS II block: Locoregional Interfascial Anesthesic Technique|PROCEDURE: ESP block: Locoregional Interfascial Anesthesic Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of SGLT2 Inhibition on Myocardial Insulin Sensitivity
Status: UNKNOWN
Conditions: Type2 Diabetes Mellitus|Stable Coronary Artery Disease
Interventions: DRUG: Dapagliflozin 10Mg Tab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety of Cyberknife in Patients With Borderline Resectable or Locally Advanced Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Pancreas Adenocarcinoma
Interventions: RADIATION: Cyberknife
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of hCG on Receptivity of the Human Endometrium
Status: COMPLETED
Conditions: Infertility|Subfertility
Interventions: DRUG: human chorionic gonadotropin (hCG)|DRUG: Placebo Comparator (for hCG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre-hospital Administration of Tranexamic Acid for Moderate and Severe Traumatic Brain Injury
Status: UNKNOWN
Conditions: Brain Injuries, Traumatic
Interventions: DRUG: Tranexamic Acid|OTHER: Sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Activated Allogeneic Lymphocytes for Induction Graft Versus Tumor Effect in Metastatic Solid Tumors
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Malignant Melanoma|Renal Cell Cancer|Gastrointestinal Cancer
Interventions: PROCEDURE: one - three cycles of cell therapy during 4-6 weeks (3-5x10^7 cells/kg will be given through IV systemically
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lopinavir Capsules to Kaletra or Invirase Tablets
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Saquinavir (Invirase®)|DRUG: Lopinavir/ritonavir (Kaletra®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of REGN1500 in Participants With Homozygous Familial Hypercholesterolemia (HoFH)
Status: COMPLETED
Conditions: Homozygous Familial Hypercholesterolemia
Interventions: DRUG: REGN1500 250 mg SC/15 mg/kg IV/450 mg SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 3-point With 1-point Mesh Fixation in TAPP for Inguinal Hernia
Status: RECRUITING
Conditions: Inguinal Hernia|Chronic Pain|Seroma|Recurrent|Infections|Hematoma
Interventions: PROCEDURE: Lightweight mesh fixation in 3 points or 1 point
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Studies by Using Alphacait to Screen Drugs for Advanced Solid Tumor
Status: UNKNOWN
Conditions: Metastatic Cancer
Interventions: DRUG: Non Chemotherapy|DRUG: Chemotherapy and target therapy|DRUG: Chinese herb medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study to Evaluate the Consistency of Next-Generation Sequencing(NGS)-Panels by Using Malignant Hydrothorax Form NSCLC
Status: UNKNOWN
Conditions: Malignant Hydrothorax|NSCLC
Interventions: DIAGNOSTIC_TEST: in vitro NGS-panel
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Safety, Tolerability and Explore the Immunogenicity of EG-HZ in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Prevention of Herpes Zoster (HZ)
Interventions: DRUG: Treatment 1 (EG-HZ-001)|DRUG: Treatment 2 (EG-HZ-002)|DRUG: Treatment 3 (EG-HZ-003)|DRUG: Treatment 4 (EG-HZ-004)|DRUG: Treatment 5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib Plus Letrozole in Hormone Receptor Positive Residual Disease After Neoadjuvant Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Palbociclib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori 23S rRNA/gyrA Gene Mutation Detection Kit (Fluorescence PCR Fusion Curve Method)
Status: COMPLETED
Conditions: Helicobacter Pylori Infection|Helicobacter Pylori gyrA Levofloxacin Resistance Mutation|Fecal Drug Resistance Gene Detection|Helicobacter Pylori Infection, Susceptibility to
Interventions: DIAGNOSTIC_TEST: Detection of fecal samples with diagnostic kit|DIAGNOSTIC_TEST: Sanger Sequencing group|DIAGNOSTIC_TEST: Bacterial culture and drug sensitivity test of gastric mucosa samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zinc Supplementation During Pregnancy: Analysis of Maternal Serum Zinc, Cord Blood Osteocalcin and Neonatal Birth Length
Status: COMPLETED
Conditions: Zinc Deficiency|Birth Length
Interventions: DIETARY_SUPPLEMENT: Zinc Supplementation Group|DIETARY_SUPPLEMENT: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Bleeding With Extended Administration of an Oral Contraceptive
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: Norethindrone 1 mg / ethinyl estradiol 20 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Immunogenicity and Safety of Combined Immunization of COVAX (Produced in Wuhan) and PPV23 / IIV4
Status: UNKNOWN
Conditions: Influenza, Human|Pneumonia, Pneumococcal|COVID-19 Pneumonia
Interventions: BIOLOGICAL: COVAX+PPV23;COVAX+IIV4|BIOLOGICAL: COVAX only (1st and 2nd dose)|BIOLOGICAL: PPV23 for the 1st dose and IIV4 for the 2nd dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Uterine Immune Profiling and Personalized Treatments in Patients Receiving a Single Blastocyst: a Matched Controlled Study
Status: COMPLETED
Conditions: Infertility|Repeated Embryos Implantation Failures|Success Rate of Assisted Reproductive Therapy
Interventions: COMBINATION_PRODUCT: Personalized care in function of the immune profile
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning
Status: COMPLETED
Conditions: Breast Cancer|Lung Cancer|Genito Urinary Cancer
Interventions: OTHER: End-of-life conversation game called "Hello"
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Digital Weight Bearing Shape Capture Socket Technology
Status: COMPLETED
Conditions: Amputation|Prosthesis User|Residual Limbs
Interventions: DEVICE: Symphonie Aqua Digital System|DEVICE: Symphonie Aqua System (Non-Digital)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of LG00034053 in Patients With Knee OA
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: LG00034053
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selection of Antibiotic Resistance by Azithromycin and Clarithromycin in the Oral Flora
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Macrolides (azithromycin or clarithromycin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Wick vs. No Wick: Does Method of Closure Affect Rate of Wound Infection?
Status: WITHDRAWN
Conditions: Postoperative Wound Infection
Interventions: PROCEDURE: Wick dressing|PROCEDURE: No Wick
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Sciatic Nerve Block for Ankle and Leg Fracture Manipulation in the Emergency Department
Status: NOT_YET_RECRUITING
Conditions: Ankle Fractures|Leg Fracture
Interventions: PROCEDURE: Ultrasound-guided Sciatic Nerve block (20 mL of 2% Lidocaine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Guided Corticosteroid Injection at A1 Pulley in Comparison to Percutaneous A1 Pulley Release as a Treatment for Idiopathic Trigger Finger
Status: COMPLETED
Conditions: US-guided Release of the A1 Pulley Responsible for Trigger Finger is Feasible With a 21-gauge Needle
Interventions: PROCEDURE: ultrasonography-guided injection|PROCEDURE: pullae A1 release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between an Electronic Mobile Device and Optical Coherence Tomography to Determine Cup-to-disc Ratio
Status: UNKNOWN
Conditions: Glaucoma
Interventions: DEVICE: Electronic Mobile Device|DEVICE: Optical Coherence Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Assess Disintegration of the New Aspirin Disintegrating Tablets
Status: COMPLETED
Conditions: Moderate Pain
Interventions: DRUG: 500 mg acetylsalicylic acid (Aspirin, BAYE4465)|DRUG: 1000 mg acetylsalicylic acid (Aspirin, BAYE4465)|DRUG: 400 mg ibuprofen(Nurofen)|DRUG: 400 mg ibuprofen (Dolormin Extra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Community Occupational Therapy in Older Patients With Dementia and Their Caregivers.
Status: UNKNOWN
Conditions: Community Occupational Therapy|Dementia Patients|Primary Caregivers of Dementia Patients
Interventions: BEHAVIORAL: community occupational therapy in dementia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Pharmacokinetics of NRL972 Following Pre-Administration of Rifampicin and Cyclosporine
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: NRL972|DRUG: NRL972|DRUG: NRL972
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF
Status: COMPLETED
Conditions: Periapical Periodontitis|Tooth Diseases|Stomatognathic Diseases
Interventions: DEVICE: PRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Efficacy of the Combination of Daratumumab (DARA) Plus Durvalumab (DURVA) (D2) in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: DARATUMUMAB|DRUG: DURVALUMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antipruritic Effect of Acupuncture in Patients With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DEVICE: Acupuncture|DEVICE: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Low Fiber Diet on Colonic Cleansing Quality (DIETPREP)
Status: COMPLETED
Conditions: Cleansing Quality of the Colon
Interventions: OTHER: One-day Low fiber diet|OTHER: Three-day low fiber diet|DRUG: Polyethylene Glycol plus ascorbic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: RCT of Goal-directed Iron Supplementation of Anemic, Critically Ill Trauma Patients, With and Without Oxandrolone
Status: WITHDRAWN
Conditions: Functional Iron Deficiency|Trauma|Anemia
Interventions: DRUG: Iron sucrose|DRUG: Oxandrolone|DRUG: IV iron placebo|DRUG: Oxandrolone placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Pravastatin for at Least 4 Weeks.
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: pravastatin tablets and Welchol tablets|DRUG: pravastatin tablets and Welchol placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy
Status: COMPLETED
Conditions: Diabetic Nephropathies
Interventions: DRUG: Pentoxifylline|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: PRIMUS002: Looking at 2 Neo-adjuvant Treatment Regimens for Resectable and Borderline Resectable Pancreatic Cancer
Status: TERMINATED
Conditions: Neoplasms Pancreatic
Interventions: DRUG: FOLFOX-A|DRUG: AG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Effectiveness of Aspirin and/or Vitamin D3 to Prevent Prostate Cancer Progression
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: High dose Aspirin & Vitamin D|DRUG: High dose Aspirin, Vitamin D placebo|DRUG: Low dose Aspirin , Vitamin D|DRUG: Low dose Aspirin, Vitamin D placebo|DRUG: Aspirin Placebo, Vitamin D|DRUG: Aspirin placebo, Vitamin D placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aprepitant in the Management of Biological Therapies-related Severe Pruritus
Status: COMPLETED
Conditions: ITCH
Interventions: DRUG: Aprepitant|DRUG: Prednisone|DRUG: Fexofenadine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Value of Circulating Tumour DNA in Follow-up of Patients With an Advanced Gastroenteropancreatic or Lung Neuroendocrine Tumour Under Everolimus +- SSA Treatment (Liquid-NET 2.0)
Status: RECRUITING
Conditions: Neuroendocrine Tumors
Interventions: OTHER: Liquid biopsies|OTHER: Scans (CT, gallium-68 DOTATE/TOC/NOC PET-CT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single and Multiple Dose Study to Explore the Safety of JNJ-38224342 in Healthy Patients and Patients With Seasonal Allergies
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: JNJ38224342|DRUG: JNJ38224342/placebo|DRUG: JNJ38224342/placebo|DRUG: JNJ38224342/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Learning Collaborative Vs Technical Assistance in Delivering a Palliative Care Program to Patients With Advanced Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Advanced Solid Tumor
Interventions: BEHAVIORAL: Virtual Learning Collaborative|BEHAVIORAL: Technical Assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Lung Elastrosonography in Diagnosis and Stratification of COPD and Fibrosis
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Smoker Lung
Interventions: DIAGNOSTIC_TEST: Lung Elastosonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: B-suture Ileostomy in Clinical Practice: a Retrospective, Single-center, Propensity Score-matched Study
Status: COMPLETED
Conditions: Ileostomy|Ileostomies|Loop Ileostomies
Interventions: PROCEDURE: B-type suture ileostomy|PROCEDURE: the traditional ileostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group-based Exercise Training Programs for Military Members With Musculoskeletal Conditions
Status: UNKNOWN
Conditions: Musculoskeletal Pain|Low Back Pain|Rotator Cuff Tendinitis|Patellofemoral Pain Syndrome|Ankle Sprains
Interventions: OTHER: Usual individual physiotherapy care|OTHER: Group-supervised physiotherapy training programs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Procedures, Complications and Follow-up of Tracheostomy in Intensive Care Units.
Status: UNKNOWN
Conditions: Respiratory Failure|Neurological Disease|Heart Failure|Airway Management
Interventions: PROCEDURE: Tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Efficacy Study of Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®) Versus Lactulose in Patients With Hepatic Encephalopathy.
Status: COMPLETED
Conditions: Hepatic Encephalopathy|Cirrhosis|Portosystemic Encephalopathy|PSE
Interventions: DRUG: Polyethylene glycol 3350-electrolyte solution (GoLYTELY®)|DRUG: Lactulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAM-315
Status: TERMINATED
Conditions: Alzheimer Disease
Interventions: DRUG: SAM-315
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Zydena on Cognitive Function of Alzheimer's Disease Patients
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: DRUG: Zydena (Udenafil) 50mg + Donepezil 5mg or 10mg|DRUG: Placebo + Donepezil 5mg or 10mg|DRUG: Zydena (Udenafil) 100mg + Donepezil 5mg or 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder With Comorbid Major Depression
Status: COMPLETED
Conditions: Panic Disorder|Major Depressive Disorder
Interventions: DEVICE: Active Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Water, Sanitation, and Hygiene Mobile Health Messages as an Innovative Tool to Facilitate Behavior Change
Status: COMPLETED
Conditions: Cholera
Interventions: BEHAVIORAL: CHoBI7 mHealth program Arm|BEHAVIORAL: general message on oral rehydration solution (ORS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Patient Centered Results for Uterine Fibroids
Status: COMPLETED
Conditions: Fibroids, Uterine
Interventions: PROCEDURE: hysterectomy|PROCEDURE: Uterine arterial embolization|PROCEDURE: myomectomy|DRUG: Medical Therapy|PROCEDURE: endometrial ablation|PROCEDURE: magnetic resonance guided focused ultrasound|PROCEDURE: radiofrequency ablation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development and Validation of a Multi-Mineral Fluoride Mouthrinse
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: Fluoride|DRUG: Fluoride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: S. Boulardii in Prevention of Antibiotic-associated Diarrhea in Hospitalized Adults With Respiratory Tract Infections
Status: COMPLETED
Conditions: Prevention & Control|Diarrhea Caused by Drug|Respiratory Infection Bacterial|Anti-Bacterial Agents
Interventions: DRUG: drug product: capsules are containing S. boulardii, administered twice daily (250 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ginseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity
Status: COMPLETED
Conditions: Blood Pressure|Cognition
Interventions: DRUG: Placebo|DRUG: Ginseng|DRUG: Ginkgo Biloba
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Influence of Triflusal on Cognitive Functions in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Triflusal|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Influence of Treatment Format on Schema Therapy for Borderline Personality Disorder
Status: ENROLLING_BY_INVITATION
Conditions: Borderline Personality Disorder
Interventions: BEHAVIORAL: Individual Schema Therapy (IST)|BEHAVIORAL: Individual-Group Schema Therapy (IGST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-course Antimicrobial Therapy for Paediatric Respiratory Infections
Status: COMPLETED
Conditions: Community-acquired Pneumonia
Interventions: DRUG: Amoxicillin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Safety and Pharmacokinetics of DO-2 in Patients With Advanced or Refractory Solid Tumours
Status: RECRUITING
Conditions: Adult Solid Tumor|Advanced Solid Tumor|Refractory Tumor|Non-small Cell Lung Cancer|Non-small Cell Carcinoma|Lung Cancer|Hereditary Renal Papillary Cancer
Interventions: DRUG: DO-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weight Loss Intervention for the Reduction of Cancer Risk and Health Disparities in Rural Ohio
Status: COMPLETED
Conditions: Obesity-Related Malignant Neoplasm
Interventions: BEHAVIORAL: Dietary Counseling and Surveillance|OTHER: Exercise Intervention|OTHER: Informational Intervention|OTHER: Questionnaire Administration|BEHAVIORAL: Telephone-Based Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Laser-assisted Combination Chemotherapy for Basal Cell Carcinoma- a Clinical Study
Status: COMPLETED
Conditions: Carcinoma, Basal Cell
Interventions: DRUG: AFL-assisted cisplatin+5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of KHK4827 in Subjects With Palmoplantar Pustulosis
Status: COMPLETED
Conditions: Palmoplantar Pustulosis
Interventions: DRUG: KHK4827|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Steroids Before Pulmonary Vein Isolation to Improve Outcomes
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Prednisone|OTHER: Placebo|PROCEDURE: Ablation Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Cannabidiol (CBD) in Pain Reduction and Opioid Use After Shoulder Arthroscopy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: CBD Oral Disintegrating Tablet (ODT)|OTHER: Placebo ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Novel Diagnostics and Probiotics to Improve Management of Paediatric Acute Gastroenteritis
Status: COMPLETED
Conditions: Acute Gastroenteritis
Interventions: OTHER: Rapid diagnostic|DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Pulmozyme (rhDNase) in Patients With Head and Neck Cancers Treated With Radiation Therapy + Chemotherapy
Status: UNKNOWN
Conditions: Head and Neck Cancer
Interventions: DRUG: Pulmozyme|DRUG: Placebo|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Patient Preferences, Analgesic Delivery Method and Pain Reduction in Spine Patients
Status: WITHDRAWN
Conditions: Pain Relief
Interventions: DRUG: Diclofenac hydroxyethylpyrrolidine|DRUG: orphenadrine|DRUG: Tramadol|DRUG: Dipyrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Measurement of the Accuracy of the "Neurolocate" Module of the Neurosurgical Robot "Neuromate" in Its Application to Deep Brain Stimulation
Status: COMPLETED
Conditions: Parkinson Disease|Dystonia|Tremor
Interventions: PROCEDURE: deep brain stimulation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Korean Red Ginseng on Central Blood Pressure in Patient With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Korean Red Ginseng Capsules|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vaginal CO2 Laser for Stress Incontinence
Status: COMPLETED
Conditions: Stress Incontinence Female|Laser
Interventions: PROCEDURE: CO2 laser- treatment (DEKA SmartXide2 Laser System, MonaLisa Touch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone Versus Depo Medrol in Lumbar Epidurals
Status: TERMINATED
Conditions: Lumbar Spine Disc Herniation|Lumbar Radiculitis|Lumbar Back Pain
Interventions: DRUG: Dexamethasone|DRUG: methylprednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Strategy Training on Improving Executive Functions in Persons Following Acquired Brain Injury
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Impairment|Stroke|Acquired Brain Injury
Interventions: BEHAVIORAL: Strategy Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Pelvic Brachytherapy With HDR Boost for Dose Escalation in High Tier Intermediate and High Risk Prostate ca
Status: UNKNOWN
Conditions: HIGH RISK PROSTATE CANCER
Interventions: RADIATION: Stereotactic Ablative Body Radiation (SBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probability of Target Attainment With Standard Intermittent Bolus Administration of Cefazolin in Patients With Complicated Infections Caused by Staphylococcus Aureus
Status: COMPLETED
Conditions: Staphylococcus Aureus Infection
Interventions: OTHER: Blood samples for the measurement of the concentration of cefazolin|OTHER: S. aureus culture isolate|OTHER: structured telephone interview|OTHER: Sub-study quantitative measurement of Torque Teno virus|OTHER: Sub-study investigating cefazolin concentrations in sweat
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Modified vs Conventional Blumgart Anastomosis of LPD for the Effects of Pancreatic Fistula of Periampullary Carcinoma
Status: ENROLLING_BY_INVITATION
Conditions: Ampullary Cancer|Bile Duct Cancer|Pancreas Cancer|Duodenum Cancer
Interventions: PROCEDURE: Modified Blumgart Anastomosis in LPD|PROCEDURE: conventional Blumgart anastomosis in LPD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2, 3 Arm Study of NVN1000 Gel and Vehicle Gel in Subjects With Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: NVN1000 1% Gel|DRUG: NVN1000 4% Gel|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Vaccine Immunotherapy (DRibbles) for Patients With Definitively-Treated Stage III Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cyclophosphamide|BIOLOGICAL: DRibble vaccine|DRUG: Imiquimod|DRUG: GM-CSF|BIOLOGICAL: HPV vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Changes in SDF-1α Levels in Acute and Stabilized Heart Disease
Status: UNKNOWN
Conditions: Atrial Fibrillation|Ischemic Heart Disease|Congestive Heart Failure
Interventions: OTHER: DYNASDY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Safety Study of LY2886721 Multiple Doses in Healthy Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: LY2886721|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability of Glyceryl Tribenzoate (GTB) Capsules in Healthy Subjects
Status: COMPLETED
Conditions: Neurological Disorder
Interventions: DRUG: Glyceryl Tribenzoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using the Chemical Modifications Present on RNA Molecules to Diagnose and Treat Brain Cancer
Status: NOT_YET_RECRUITING
Conditions: Glioma
Interventions: DIAGNOSTIC_TEST: Blood, urine and tumoral tissue samples|DIAGNOSTIC_TEST: Tumoral tissue samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating the Impact of the 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Alaskan Native Children.
Status: COMPLETED
Conditions: Pneumococcal Disease|13-valent Pneumococcal Vaccine
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Clinical Study on Causticum 200 Centesimal Potency in Primary Enuresis
Status: UNKNOWN
Conditions: Bed Wetting|Primary Enuresis
Interventions: DRUG: Homoeopathic Medicine causticum 200c
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dupilumab in Adult Participants With Active Eosinophilic Esophagitis (EoE)
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Dupilumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Testing of Chenopodium Formosanum Extracts on Skin Beauty
Status: COMPLETED
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Chenopodium formosanum extracts sachet|DIETARY_SUPPLEMENT: Placebo sachet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome
Status: TERMINATED
Conditions: Complex Regional Pain Syndrome
Interventions: DRUG: Ketamine Infusion + Epidural Infusion|DRUG: Control Group + Epidural infusion|DRUG: Ketamine Booster Infusion|DRUG: Control Group Booster Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vancomycin Dosing for Serious MRSA Infections: A Non-inferiority Randomized Trial of Trough Level Versus AUC/MIC
Status: RECRUITING
Conditions: MRSA
Interventions: DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing in Patients With Schizophrenia
Status: COMPLETED
Conditions: Motivational Interviews|Schizophrenia
Interventions: BEHAVIORAL: 6-session Interpersonal Relations Theory-based Motivational Interviews and 3 month follow-up.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fruit-based Chewing Gums for Improving Oral Health
Status: COMPLETED
Conditions: Oral Health
Interventions: OTHER: polyphenol-lecithin precipitate (PLP)|OTHER: control formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Zip Incision Approximation vs. Suture for C-Section
Status: UNKNOWN
Conditions: C.Surgical Procedure; Dehiscence, Cesarean Section
Interventions: DEVICE: Zip Surgical Skin Closure Device|OTHER: Conventional Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation
Status: RECRUITING
Conditions: Lower Limb Amputation Below Knee (Injury)|Diurnal Residual Limb Fluid Volume Fluctuation
Interventions: DEVICE: Auto Adjusting Prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tumor and Vaccine Site With a Toll Like Receptor (TLR) Agonist
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: gp100|DRUG: R848 gel|DRUG: MAGE-3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT