pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration
Interventions: GENETIC: SKG0106
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis
Status: RECRUITING
Conditions: Spinal Metastases|Blood Transfusion Complication|Lung Cancer|Surgery|Autologous Blood Transfusion
Interventions: PROCEDURE: Autoblood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Late Phase II Study of Weekly Paclitaxel (BMS-181339) in Patients With Advanced or Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Umbilical Cord-derived Mesenchymal Stem Cells With Injectable Collagen Scaffold Transplantation for Chronic Ischemic Cardiomyopathy
Status: COMPLETED
Conditions: Chronic Ischemic Cardiomyopathy
Interventions: BIOLOGICAL: hUC-MSCs+Injectable collagen scaffold+CABG|BIOLOGICAL: hUC-MSCs+CABG|PROCEDURE: CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease
Status: TERMINATED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: Intranasal Tear Neurostimulator (ITN) [TrueTear®]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Validate the Safety and Feasibility of the CT-guided Interventional Robot in Percutaneous Biopsy Procedure.
Status: COMPLETED
Conditions: Abdominal Cancer|Thoracic Cancer
Interventions: PROCEDURE: CT-fluoroscopy guided robot-assisted biopsy of thoracic and abdominal lesions|PROCEDURE: Freehand CT-guided percutaneous needle biopsy of thoracic and abdominal lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors
Status: COMPLETED
Conditions: Childhood Atypical Teratoid/Rhabdoid Tumor|Childhood Central Nervous System Germ Cell Tumor|Childhood Cerebral Anaplastic Astrocytoma|Childhood Cerebral Astrocytoma|Childhood Grade I Meningioma|Childhood Grade II Meningioma|Childhood Grade III Meningioma|Childhood Infratentorial Ependymoma|Childhood Oligodendroglioma|Childhood Spinal Cord Neoplasm|Childhood Supratentorial Ependymoma|Recurrent Childhood Brain Neoplasm|Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Cerebral Astrocytoma|Recurrent Childhood Ependymoma|Recurrent Childhood Medulloblastoma|Recurrent Childhood Pineoblastoma|Recurrent Childhood Subependymal Giant Cell Astrocytoma|Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor|Recurrent Childhood Visual Pathway Glioma
Interventions: DRUG: Cediranib Maleate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Sitting SRP vs Supra-gingival Scaling Followed by Sub-gingival SRP After One Week
Status: UNKNOWN
Conditions: Periodontitis
Interventions: PROCEDURE: SCALING AND ROOT PLANING (SRP)in single sitting|PROCEDURE: SCALING AND ROOT PLANING (SRP)in two sittings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Pharmacodynamics of IPX054 in Subjects With Parkinson's Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Interventions: DRUG: IPX054 100 mg|DRUG: IPX054 150 mg|DRUG: IPX054 200 mg|DRUG: IPX054 250 mg|DRUG: IPX054 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fiberoptic Endoscopic Evaluation of Swallowing(FEES) in Infants Graduated From (NICU) Neonatal Intensive Care Unite
Status: UNKNOWN
Conditions: Fiberoptic Endoscope Evaluation of Swallowing in Infants(FEES)
Interventions: DEVICE: fiberoptic endoscopic evaluation of swallowing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
Status: COMPLETED
Conditions: Acute Bleeding Esophageal Varices
Interventions: DEVICE: Self-expanding mesh-metal oesophageal stent (SEMS)|OTHER: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo in Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: Quetiapine fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Arsenic Trioxide, and Temozolomide in Treating Patients With Newly Diagnosed High-Grade Glioma
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: arsenic trioxide|DRUG: temozolomide|PROCEDURE: adjuvant therapy|RADIATION: intensity-modulated radiation therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Erythropoietin During Cerebral Malaria
Status: UNKNOWN
Conditions: Cerebral Malaria
Interventions: DRUG: Placebo|DRUG: Erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Efficacy and Safety of Valdecoxib Plus Parecoxib Versus Valdecoxib Plus Placebo for the Treatment of Pain After Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Parecoxib Sodium/Valdecoxib|DRUG: Placebo/Valdecoxib|OTHER: Placebo/Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GARDASIL™ Study in Healthy Females Between 9 and 26 Years of Age in Sub-Saharan Africa (V501-046)
Status: COMPLETED
Conditions: Papillomavirus Infections
Interventions: BIOLOGICAL: Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine (GARDASIL™)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Evaluation of PLB1004 in Patients With Non-squamous NSCLC Harboring EGFR Exon 20 Insertion.
Status: NOT_YET_RECRUITING
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: PLB1004|DRUG: Pemetrexed+（carboplatin or Cisplatin）with or without Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Paclitaxel Trial In Recurrent and Metastatic Breast Cancer As 1st Line Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent or Metastatic Breast Cancer
Interventions: DRUG: Oral paclitaxel|DRUG: Paclitaxel injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term One Year Use of Alefacept (Amevive®) in Moderate to Severe Chronic Plaque Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Alefacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BrUOG 329 Onivyde & Metronomic Temozolomide in Recurrent Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma Multiforme|Glioblastoma|GBM
Interventions: DRUG: Nanoliposomal Irinotecan|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Single Use (Ambu aScope) and a Reusable Flexible Optical Scope for Intubation Through a Supraglottic Airway Device (Aura-i)
Status: UNKNOWN
Conditions: General Anesthesia
Interventions: PROCEDURE: tracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Intervention to Examine the Effect of Vitamin D on Urine Protein Levels in Type 2 Diabetes
Status: UNKNOWN
Conditions: Diabetic Nephropathies
Interventions: DRUG: Calcitriol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2 Study of BKM120 Plus Trastuzumab in Patients With HER2-positive Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer|HER2+ Breast Cancer
Interventions: DRUG: BKM120|DRUG: Trastuzumab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery
Status: RECRUITING
Conditions: Intraoperative Arterial Hypotension
Interventions: OTHER: Non-invasive cerebral oximetry monitoring|OTHER: additional perioperative blood sampling|OTHER: clinical & telephone assessments|OTHER: Non-invasive somatic oximetry monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Increasing Awareness of Opioid Disposal in the Orthopedic Patient Population
Status: COMPLETED
Conditions: Knee Total Joint Replacement|Hip Total Joint Replacement
Interventions: BEHAVIORAL: Education on disposal of opioids
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Low Dose Buprenorphine on Recovery After Hip or Knee Arthroplasty
Status: COMPLETED
Conditions: Pain|Osteoarthritis
Interventions: DRUG: Buprenorphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ESTIA: Computerized Intervention Targeting Cognitive Control Deficits in Depressed Adults
Status: COMPLETED
Conditions: Major Depression
Interventions: BEHAVIORAL: Band Together|OTHER: Control Mobile 3D video game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study to Determine the Effect of Lenvatinib (E7080) on the Pharmacokinetics of Midazolam in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Tumors
Interventions: DRUG: Lenvatinib|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Study the Effectiveness and Safety of Niacin and a Topical Steroid Eye Drop to Treat Retinal Vein Occlusions
Status: COMPLETED
Conditions: Retinal Vein Occlusion
Interventions: DRUG: Nicotinic acid|DRUG: Prednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy of a Psychological Therapy in Inpatients With a Schizophrenic Psychosis
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Psychotic Disorders
Interventions: BEHAVIORAL: Integrated Neurocognitive Therapy (INT)|BEHAVIORAL: Integrated Psychological Therapy (IPT)|OTHER: COGPACK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Terbinafine HCl 250 mg Tablet Formulations Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Terbinafine HCl 250mg tablets|DRUG: Lamisil® 250 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cyclophosphamide|DRUG: fludarabine phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: GVM±R in Patients With Relapsed or Refractory Aggressive NHL
Status: ACTIVE_NOT_RECRUITING
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: Liposomal Mitoxantrone Hydrochloride dose level 1|DRUG: Liposomal Mitoxantrone Hydrochloride dose level 2|DRUG: Liposomal Mitoxantrone Hydrochloride dose level 3|DRUG: Liposomal Mitoxantrone Hydrochloride dose level 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "FEXIS": (Feasibility of an Extended Wear CSII Set in Participants With T1DM)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Type 1 Diabetes|Type 1 Diabetes Mellitus|Diabetes Mellitus, Insulin-Dependent, 1
Interventions: DEVICE: coil-reinforced soft polymer indwelling cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: External Micropulse Diode Laser Transscleral Trabeculoplasty (EMDLT) for Severe Open Angle Glaucoma
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma
Interventions: DEVICE: EXTERNAL MICROPULSE DIODE LASER TRANSSCLERAL TRABECULOPLASTY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interpersonal Psychotherapy in Youth With Severe Mood Dysregulation-Pilot
Status: COMPLETED
Conditions: Severe Mood Dysregulation
Interventions: BEHAVIORAL: Interpersonal Psychotherapy for youth with SMD (IPT-SMD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardio Risk of Acute Schizophrenia Olanzapine Duke
Status: WITHDRAWN
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Olanzapine|DRUG: Metformin|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Mantle Cell Lymphoma
Interventions: DRUG: Acalabrutinib|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib in Combination With Capecitabine in Japanese Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Neoplasms, Breast
Interventions: DRUG: Lapatinib|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide 1.34 mg/mL|DRUG: Semaglutide 3.0 mg/mL|DRUG: NNC0480-0389 10 mg/mL|DRUG: NNC0480-0389 30 mg/mL|DRUG: Microgynon®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Multiparametric Prostate MRI and Ga-68 PSMA PET Imaging in Prostate Cancer Staging
Status: UNKNOWN
Conditions: Prostate Cancer|Prostate Cancer Stage
Interventions: DIAGNOSTIC_TEST: Multiparametric Prostate MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Knee Osteoarthritis: Platelet Rich Plasma or Hyaluronic Acid
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Platelet Rich Plasma Treatment Group (PRP)|DEVICE: Hyaluronic Acid Treatment Group (HA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology
Status: COMPLETED
Conditions: Schistosomiasis Mansoni|HIV
Interventions: DRUG: Praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Versus Ultrasound Approach for Serratus Anterior Block
Status: COMPLETED
Conditions: Analgesia
Interventions: PROCEDURE: ultrasound approach of serratus anterior block|PROCEDURE: open approach of serratus anterior block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of STSP-0601 in Adult Patients With Hemophilia A or B With Inhibitor
Status: UNKNOWN
Conditions: Hemophilia
Interventions: DRUG: STSP-0601 for Injection|DRUG: STSP-0601 for Injection|DRUG: STSP-0601 for Injection|DRUG: STSP-0601 for Injection|DRUG: STSP-0601 for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tandem High Dose Melphalan Versus Triple Intermediate Dose Melphalan and Stem Cell Transplantation in Induction Phase and Prednisolone/IFN Versus IFN in Maintenance Therapy
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin on Visual Function in Patients With Glaucoma
Status: UNKNOWN
Conditions: Primary Open Angle Glaucoma
Interventions: DRUG: Metformin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Succinylcholine or Rocuronium for Rigid Bronchoscopy Under General Anesthesia
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: succinylcholine|DRUG: rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Central Compartment Dissection Without Thyroidectomy
Status: UNKNOWN
Conditions: Thyroidectomy|Thyroid Cancer|Central Compartment Neck Dissction
Interventions: PROCEDURE: Conventional|PROCEDURE: central neck dissection first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Usability and Effectiveness of the ATLAS2030 Exoskeleton in Children With Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DEVICE: ATLAS 2030 exoskeleton
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extension Study of An Investigational Drug in Patients With Hypercholesterolemia (0653A-038)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: MK0653A, ezetimibe (+) simvastatin / Duration of Treatment: 14 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Kentucky Viral Hepatitis Treatment Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatitis C|Opioid-Related Disorders|Injection Drug Use
Interventions: DRUG: Sofosbuvir/velpatasvir (Epclusa®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Superdonor FMT in Patients With Ulcerative Colitis
Status: RECRUITING
Conditions: Active Ulcerative Colitis
Interventions: BIOLOGICAL: FMT|OTHER: Placebo FMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Beta-glucan Enriched Barley Flour in Bread on Glycemic Response
Status: COMPLETED
Conditions: Glycemic Index
Interventions: OTHER: REFERENCE: white bread|OTHER: TEST: b-glucan enriched bread
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Aldesleukin and Pembrolizumab in Treating Patients With Stage III-IV Melanoma
Status: TERMINATED
Conditions: Metastatic Melanoma|Stage III Mucosal Melanoma of the Head and Neck|Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma|Stage IV Skin Melanoma|Stage IVA Mucosal Melanoma of the Head and Neck|Stage IVB Mucosal Melanoma of the Head and Neck|Stage IVC Mucosal Melanoma of the Head and Neck
Interventions: BIOLOGICAL: Aldesleukin|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Daily Consumption of Glycomacropeptide on Gut Microbiome and Blood Functional Proteome of Subjects With Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Inflammatory Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Casein glycomacropeptide (CGMP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Study of ZL-1218 in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Malignant Solid Tumor
Interventions: DRUG: ZL-1218|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Resveratrol for Pain Due to Endometriosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Placebo|DRUG: Resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer Treatment
Status: COMPLETED
Conditions: Head and Neck Carcinoma|Hypopharyngeal Carcinoma|Laryngeal Carcinoma|Maxillary Sinus Carcinoma|Oral Cavity Carcinoma|Oropharyngeal Carcinoma|Paranasal Sinus Carcinoma|Sinonasal Carcinoma|Stage I Laryngeal Cancer AJCC v8|Stage II Laryngeal Cancer AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage IV Laryngeal Cancer AJCC v8|Stage IVA Laryngeal Cancer AJCC v8|Stage IVB Laryngeal Cancer AJCC v8|Stage IVC Laryngeal Cancer AJCC v8|Lung Carcinoma
Interventions: OTHER: Medical Device Usage and Evaluation|OTHER: Consultation|OTHER: Exercise Intervention|BEHAVIORAL: Behavioral Intervention|OTHER: Questionnaire Administration|OTHER: Quality of Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacokinetics of Single Rising Oral Doses of KUC 7483 CL Tablets in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: KUC 7483 CL - single rising dose|DRUG: Placebo|OTHER: standardized high fat meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Palonosetron Plus Aprepitant Versus Palonosetron in Preventing Nausea and Vomiting in Leukemic Patients
Status: UNKNOWN
Conditions: Chemotherapy Induced Nausea and Vomiting
Interventions: DRUG: Palonosetron + Aprepitant|DRUG: Palonosetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Investigate the Safety and Pharmacokinetic/Pharmacodynamic Characteristics of HSG4112
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: HSG4112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study Of PF-06291874 In Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06291874|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultra-portable Ultrasound vs. Standard Ultrasound to Help Place a Peripheral Catheter in Patients at Risk of Difficult Puncture
Status: NOT_YET_RECRUITING
Conditions: IV Line Placement With Ultrasound
Interventions: DEVICE: Standard ultrasound|DEVICE: Ultra-portable ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of LY2334737 in Participants With Cancer That is Advanced and/or Has Spread
Status: COMPLETED
Conditions: Malignant Solid Tumor|Solid Tumor|Metastatic Tumor
Interventions: DRUG: LY2334737
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Adenoid Cystic Carcinoma on 68Ga-PSMA-617 PET-CT and Therapy With 177Lu-EB-PSMA-617
Status: UNKNOWN
Conditions: Adenoid Cystic Carcinoma
Interventions: DRUG: 68Ga-PSMA|DRUG: 1.85GBq (50 mCi) of 177Lu-EB-PSMA-617
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluate Time Associated With the Preparation & Administration of Denosumab/Pamidronate in Patients With Solid Tumors and Metastatic Bone Disease
Status: WITHDRAWN
Conditions: Solid Tumor|Metastatic Bone Disease
Interventions: BIOLOGICAL: denosumab|DRUG: pamidronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem
Status: TERMINATED
Conditions: Osteoarthritis|Avascular Necrosis|Rheumatoid Arthritis|Congenital Dysplasia of the Hip|Ankylosing Spondylitis|Post-traumatic; Arthrosis|Injury of Hip and Thigh
Interventions: DEVICE: Metal on Metal Hip System|DEVICE: Highly Cross Linked Polyethylene cup System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ganglion Impar Denervation and Radiofrequency on Sacral Root 3 for Chronic Prostatic Pain
Status: UNKNOWN
Conditions: Chronic Pain
Interventions: PROCEDURE: pulsed radiofrequency|PROCEDURE: ganglion impar denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Computerised Versus Interviewer-administered Approach for Assessing Health-related Quality of Life
Status: COMPLETED
Conditions: Diabetes|Heart Disease|Hypertension|Stroke
Interventions: OTHER: Health-related quality of life assessment|OTHER: Health-related quality of life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Safety and Efficacy of Neoadjuvant Immunochemotherapy Followed by Laparoscopic Gastrectomy for Gastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Gastric Cancer
Interventions: DRUG: immune checkpoint inhibitors: sintilimab, nivolumab, and camrelizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Computer-based Tutorial and Automated Speech Recognition for Intravitreal Drug Injections
Status: UNKNOWN
Conditions: Age-related Macular Degeneration|Retinal Vein Occlusion|Diabetic Macular Edema
Interventions: OTHER: MacInfo presentation|OTHER: Placebo presentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Healthy Volunteers
Status: COMPLETED
Conditions: Thalassemia
Interventions: DRUG: IONIS TMPRSS6-Lrx|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Efficacy of Pioglitazone to Promote Renal Tolerance in ANCA-associated Vasculitis - RENATO Trial
Status: RECRUITING
Conditions: ANCA Associated Vasculitis|Rapidly Progressive Glomerulonephritis|Crescentic Glomerulonephritis
Interventions: DRUG: Pioglitazone (ACTOS®)|DRUG: Placebo of Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Killer Cell Therapy in Colon Cancer Patients
Status: UNKNOWN
Conditions: Colon Cancer Stage IV
Interventions: BIOLOGICAL: Cytokine-induced killer cell|OTHER: Chemotherapy AND/OR Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Florbetapir Calibration to the Centiloid Scale
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Florbetapir (18F)|DRUG: 11C-PiB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy Study of DiaPep277 in Newly Diagnosed Type 1 Diabetes Patients
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: DiaPep277|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Self-management Programmes for Patients With Back Pain
Status: UNKNOWN
Conditions: Lower Back Pain Chronic
Interventions: BEHAVIORAL: The Pain Toolkit|BEHAVIORAL: the Back Book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Potential Phototoxicity Skin Reaction After Use of MC2-01 Cream
Status: COMPLETED
Conditions: Phototoxicity
Interventions: DRUG: MC2-01 Cream, irradiation|DRUG: MC2-01 Cream, no irradiation|DRUG: MC2-01 vehicle, irradiation|DRUG: MC2-01 vehicle, no irradiation|DRUG: Control, irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and PK of Ensovibep (MP0420 - a New Candidate With Potential for Treatment of COVID-19)
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Ensovibep|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety Study to Determine the Appropriate Dose of Antibody Against Tumor Cells to Best Target Patients With Pancreatic Cancer.
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Radiolabeled humanized PAM4 IgG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Re-Inventing Yourself After Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: BEHAVIORAL: SCI Reinvention Protocol Participants|OTHER: Waitlist Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Diagnostic Self-testing Using Virtual Point-of-care
Status: UNKNOWN
Conditions: Communicable Disease|COVID-19|Sars-CoV2|Infectious Disease|Coronavirus|Virus
Interventions: DIAGNOSTIC_TEST: COVID-19 Antigen/Antibody Rapid Testing, mobile device image capture and telemedicine support|OTHER: Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of Nitazoxanide (NTX) in the Treatment of Patients With SARS-CoV-2 Virus Infection (COVID-19)
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Nitazoxanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Magnetic Innervation in Combination With Mirabegron in the Treatment of Overactive Bladder
Status: COMPLETED
Conditions: Overactive Bladder|Overactive Bladder Syndrome
Interventions: DRUG: mirabegron 50 mg daily|DEVICE: Extracorporeal magnetic innervation (active treatment)|DEVICE: Extracorporeal magnetic innervation (sham treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Vibrational Anesthesia in Scalp Platelet Rich Plasma (PRP)
Status: NOT_YET_RECRUITING
Conditions: Alopecia
Interventions: DEVICE: Vibrational Anesthesia (VA) Device|PROCEDURE: PRP Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 'Penny', a SMS Text-based Chatbot Intervention for Medication Adherence and Side Effect Management Among Patients With GI Cancers
Status: RECRUITING
Conditions: Gastrointestinal Cancer
Interventions: DEVICE: 'Penny' via Memora Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Monogenic Diabetes Misdiagnosed as Type 1
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Monogenic Diabetes|Neonatal Diabetes|Maturity-onset Diabetes in the Young (MODY)|Wolfram Syndrome|Wolcott-Rallison Syndrome|Mitochondrial Diabetes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations
Status: UNKNOWN
Conditions: Root Canal Therapy
Interventions: PROCEDURE: Gutta Percha and AHPLUS cement (group A)|PROCEDURE: PBS CIMMO cement (group B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fetal and Neonatal Magnetophysiology
Status: COMPLETED
Conditions: Fetal Arrhythmia|Abnormality in Fetal Heart Rate or Rhythm|Long QT Syndrome
Interventions: DEVICE: magnetocardiography|DEVICE: postnatal ECG|DEVICE: fetal echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Split-dose Versus Same-day Reduced-volume PEG-ELS Plus Bisacodyl for Morning Colonoscopy
Status: COMPLETED
Conditions: Bowel Preparation for Morning Colonoscopy
Interventions: OTHER: Split-dose|OTHER: Same-morning whole-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Conivaptan for the Correction of Hyponatremia in Neurological Patients
Status: WITHDRAWN
Conditions: Hyponatremia
Interventions: DRUG: Conivaptan|OTHER: D5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arterial Closure vs Direct Compression for Hemostasis After PCI - The ACDC Trial
Status: COMPLETED
Conditions: Coronary Angioplasty|Coronary Artery Disease
Interventions: PROCEDURE: Closure Device|PROCEDURE: Direct Compression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pulsed Shortwave Therapy (ActiPatch®) Study in Chronic Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low Back Pain
Interventions: DEVICE: Pulsed Shortwave Therapy|DEVICE: Placebo Pulsed Shortwave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Safety Trial of BNT331 Administered as Single Ascending Doses in Healthy Women and as Multiple Ascending Doses in Women Diagnosed With Bacterial Vaginosis
Status: RECRUITING
Conditions: Bacterial Vaginosis
Interventions: DRUG: BNT331|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIfurcation Optimal Treatment Strategy With LYMus Eluting Dedicated Bifurcation Versus Convention Stent Randomized Study
Status: UNKNOWN
Conditions: Coronary Bifurcation Stenosis
Interventions: DEVICE: BIOSS LIM implantation|DEVICE: BIOSS Lim|DEVICE: CarloS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study With Hiltonol and Dendritic Cells in Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: BIOLOGICAL: Hiltonol and autologous dendritic cells|RADIATION: Hiltonol, dendritic cells and radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Azimilide in the Prophylactic Treatment of Patients With Atrial Fibrillation.
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Azimilide Dihydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy
Status: RECRUITING
Conditions: Epilepsy, Post-Traumatic
Interventions: DRUG: [18F]DPA-714 Positron Emission Tomography Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT Pilot)
Status: COMPLETED
Conditions: Critically Ill|Deep Venous Thrombosis
Interventions: DRUG: Fragmin (Dalteparin) LMWH verus Unfractionated Heparin (UFH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMT
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Alemtuzumab GZ402673|DRUG: Glatiramer acetate|DRUG: Beta-Interferon|DRUG: Methylprednisolone|DRUG: Ranitidine|DRUG: Ceterizine|DRUG: Dexchlorpheniramine|DRUG: Paracetamol|DRUG: Acyclovir|DRUG: Prednisolone|DRUG: Diphenydramine|DRUG: Other H1 antagonist|DRUG: Other H1 antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study
Status: COMPLETED
Conditions: Pulmonary Emphysema|Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Biologic Lung Volume Reduction (BLVR) - 20 mL Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capecitabine Plus Pembrolizumab in Patients With Triple Negative Breast Cancer After Chemo-immunotherapy and Surgery
Status: NOT_YET_RECRUITING
Conditions: Triple Negative Breast Neoplasms
Interventions: DRUG: Pembrolizumab injection|DRUG: Capecitabine tablets|RADIATION: Local radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring Emotional Intelligence and Cognitive Flexibility in Anorexia Nervosa and Parkinson's Disease.
Status: RECRUITING
Conditions: Anorexia Nervosa|Parkinson Disease
Interventions: DIAGNOSTIC_TEST: Neuropsychological tests in PD|DIAGNOSTIC_TEST: Self-report questionnaires in PD|DEVICE: International Affective Picture System (IAPS)|DIAGNOSTIC_TEST: Neuropsychological tests in AN|DIAGNOSTIC_TEST: Self-report questionnaires in AN|DIAGNOSTIC_TEST: Analysis of bio-humoral parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Safety of Budesonide/Glycopyrronium/Formoterol Fumarate With the Hydrofluoroolefin Propellant in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: BGF MDI HFO 320/14.4/9.6 μg|DRUG: BGF MDI HFA 320/14.4/9.6 μg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin in Treating Patients With Liver Cancer
Status: COMPLETED
Conditions: Adult Primary Hepatocellular Carcinoma|Advanced Adult Primary Liver Cancer|Localized Unresectable Adult Primary Liver Cancer|Recurrent Adult Primary Liver Cancer
Interventions: DRUG: oxaliplatin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Status: COMPLETED
Conditions: Sarcopenia
Interventions: BEHAVIORAL: High intensity aerobic exercise|BEHAVIORAL: Resistance exercise training|BEHAVIORAL: Combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hypobaric Lateral Spinal Anesthesia Versus General Anesthesia for the Hip Fracture Surgery
Status: COMPLETED
Conditions: Hip Fractures
Interventions: PROCEDURE: Unilateral spinal anesthesia|PROCEDURE: General anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proleukin in Combination With Rituxan in Patients With Intermediate and High-Grade Non-Hodgkin's Lymphoma.
Status: COMPLETED
Conditions: Lymphoma, Non-Hodgkin
Interventions: DRUG: Recombinant Human Interleukin-2 and Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Short-Term Fasting: Impact on Toxicity
Status: ACTIVE_NOT_RECRUITING
Conditions: Fasting in Malignant Solid Tumors
Interventions: OTHER: Short-term fasting|OTHER: Modified fast|OTHER: Fasting|OTHER: Fasting|OTHER: Fasting|OTHER: Fasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Hylenex in the Treatment of Pain Among Hospice Patients
Status: COMPLETED
Conditions: Pain Management
Interventions: DRUG: Hylenex recombinant , morphine, saline|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Vitamin D Levels (Serum 25-hydroxyvitamin D) and Cognitive Impairment in the Occurrence of Falls
Status: UNKNOWN
Conditions: Accidental Falls
Interventions: OTHER: Measurement of serum 25-hydroxyvitamin D|OTHER: Analysis of global cognitive efficiency score assessed by the "Montreal Cognitive Assessment" (MoCA).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Safety and Efficacy of PEP005(Ingenol Mebutate) Gel, 0.05%, in Patients With Seborrhoeic Keratosis
Status: COMPLETED
Conditions: Seborrheic Keratosis
Interventions: DRUG: PEP005 (ingenol mebutate) Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Bevacizumab Plus RAD001 Versus Interferon Alfa-2a and Bevacizumab for the First-line Treatment in Adult Patients With Kidney Cancer
Status: COMPLETED
Conditions: Carcinoma|Adenocarcinoma|Renal Cell|Nephroid Carcinoma|Hypernephroid
Interventions: DRUG: RAD001(everolimus)|DRUG: interferon alfa-2a|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Cardiac Surgery With a Minimal Invasive Extracorporeal Circuit οn Coagulation: Data From Point of Care Devices
Status: COMPLETED
Conditions: Extracorporeal Circulation; Complications|Coagulation Disorder|Extracorporeal Circulation of Blood; Thrombocytopenia
Interventions: DIAGNOSTIC_TEST: Thromboelastometry, Impedance Aggregometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lumbar to Sacral Ventral Nerve Re-Routing
Status: COMPLETED
Conditions: Urinary Incontinence|Spinal Cord Injury|Spina Bifida
Interventions: PROCEDURE: lumbar to sacral ventral nerve re-routing procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT