pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Evaluation of AN777 in Elderly Subjects
Status: COMPLETED
Conditions: Aged
Interventions: OTHER: Ad lib diet and Control placebo|OTHER: Ad lib diet and An 777|OTHER: Ad lib diet/ placebo/ exercise|OTHER: Ad lib diet; AN 777; exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diazepam Vaginal Suppositories for High Tone Pelvic Floor Dysfunction.
Status: COMPLETED
Conditions: Female Patients With High Tone Pelvic Floor Dysfunction
Interventions: DRUG: Vaginal Diazepam Suppository|DRUG: Placebo Suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Extension Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension
Status: RECRUITING
Conditions: Hypercholesterolemia
Interventions: DRUG: Enlicitide Decanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of L-DOPA for Depression and Slowing in Older Adults
Status: COMPLETED
Conditions: Major Depressive Disorder|Dysthymia|Depression Not Otherwise Specified|Decreased Processing Speed|Decreased Gait Speed
Interventions: DRUG: Levodopa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Benfotiamine on Intraepidermal Nerve Fiber Density (IENFD)
Status: UNKNOWN
Conditions: Diabetic Neuropathies
Interventions: DRUG: Benfotiamine|DRUG: Placebo for benfotiamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acupoint Application With Yanqing Zhitong Ointment for Chronic Non-specific Low Back Pain
Status: RECRUITING
Conditions: Non-specific Low Back Pain
Interventions: OTHER: Yanqing Zhitong Ointment Acupoint application|OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating and Improving Functional Driving Vision of Patients With Astigmatism
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: 1-DAY ACUVUE® MOIST contact lenses|DEVICE: 1-DAY ACUVUE® MOIST for ASTIGMATISM contact lenses|OTHER: No contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Paretic Lower Limb Loading During Over-ground Training Among Stroke Survivors
Status: COMPLETED
Conditions: Stroke|Hemiparesis;Poststroke/CVA
Interventions: BEHAVIORAL: Warm-up (5 minutes)|BEHAVIORAL: Conventional physiotherapy exercise (15 minutes)|BEHAVIORAL: Over-ground training with lower limb loading (15-25 minutes)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nol-Index Guided Remifentanil Analgesia Versus Standard Analgesia During Moderate-to-High Risk Cardiovascular Surgery
Status: COMPLETED
Conditions: Nociceptive Pain|Goal-directed Therapy|Hemodynamic Instability|Nol-Index|Remifentanil|Cardiac Surgery|Vascular Surgery|General Anesthesia
Interventions: DEVICE: Nol-Index guided analgesia|OTHER: Standard Analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Solid Formulations of JNJ-39393406 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ 39393406 30 mg solid X|DRUG: JNJ 39393406 30 mg solid Y|DRUG: JNJ 39393406 120 mg solid X|DRUG: JNJ 39393406 120 mg solid Y|DRUG: JNJ 39393406 30 mg solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ramosetron, Aprepitant and Dexamethasone Versus Ondansetron, Aprepitant and Dexamethasone
Status: UNKNOWN
Conditions: Cancer|Malignancy
Interventions: DRUG: ramosetron|DRUG: ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of High-frequency rTMS in Reducing Alcohol Consumption in Non-abstinent Patients With an Alcohol Use Disorder
Status: RECRUITING
Conditions: Alcoholism|rTMS Stimulation
Interventions: DEVICE: Active rTMS|DEVICE: Placebo rTMS|OTHER: Questionnaires|DEVICE: Breathalyzer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate Counting in Adults With Type 1 Diabetes Treated With Continuous Subcutaneous Insulin Infusion
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Insulin Pump, Programmable
Interventions: BEHAVIORAL: Carbohydrate counting training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Multi Site, Randomized, Double Blind, Placebo Controlled Study Of The Efficacy And Safety Comparing CP- 690,550 And Etanercept In Subjects With Moderate To Severe Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: CP 690,550 5 mg|DRUG: CP 690,550 10 mg|BIOLOGICAL: Etanercept 50 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Joint Movement to Increase Range of Motion in Knee Joint After Primary Total Knee Arthroplasty
Status: ENROLLING_BY_INVITATION
Conditions: Total Knee Arthroplasty
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers
Status: COMPLETED
Conditions: Venous Stasis Ulcers
Interventions: DRUG: Thymosin Beta 4|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Procalcitonin Protocol to Shorten the Antibiotic Therapy in Febrile Neutropenia
Status: COMPLETED
Conditions: Febrile Neutropenia
Interventions: OTHER: procalcitonin|DRUG: antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 2-Hydroxybenzylamine (2-HOBA) to Prevent Early Recurrence of Atrial Fibrillation After Catheter-based Ablation
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: 2-Hydroxybenzylamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Chlorohexidine Versus Povidone Iodine as Apreoperative Ophthalmic Disinfectant
Status: UNKNOWN
Conditions: Disinfectant Causing Toxic Effect
Interventions: DRUG: Chlorhexidine|DRUG: Povidone-Iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength, Pain and Mobilization After Total Knee Replacement
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: PROCEDURE: Adductor-Canal-Blockade|PROCEDURE: Femoral Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Focused Extracorporeal Shockwave Therapy for Knee Arthritis
Status: RECRUITING
Conditions: Bone Marrow Edema|Knee Osteoarthritis|Knee Pain Chronic
Interventions: DEVICE: Focused extracorporeal shockwave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Correlation Between C-11 Acetate Uptake and Retention as Measured by PET and FAS in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: C-11 acetate PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: In Vivo Efficacy Study of Patient Preoperative Preps
Status: COMPLETED
Conditions: Bacterial Reduction Post-product Application
Interventions: DRUG: 3M CHG/IPA Prep C|DRUG: 3M CHG/IPA Prep CH|DRUG: ChloraPrep|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biotin Deficiency and Restless Legs Syndrome
Status: COMPLETED
Conditions: End Stage Renal Disease|Restless Legs Syndrome
Interventions: DIETARY_SUPPLEMENT: Biotin Supplementation|DIETARY_SUPPLEMENT: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunologic and Virologic Consequences of Long-Term Highly Active Antiretroviral Therapy (HAART) in Subjects With Moderately Advanced HIV-1 Disease: A Follow-Up Study to ACTG 315
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Saquinavir|DRUG: Delavirdine mesylate|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease
Status: COMPLETED
Conditions: Coronavirus|Acute Respiratory Infection|SARS-CoV Infection
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of a New Formula on the Growth, Safety and Tolerance of Infants With Growth Failure
Status: COMPLETED
Conditions: Growth Failure|Congenital Heart Disease
Interventions: OTHER: New Infant Formula
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Posteromedial Tibiofemoral Incongruence (PMTFI) Treatment
Status: RECRUITING
Conditions: Meniscus Disorder|Meniscus; Degeneration|Meniscus Tear|Meniscus Lesion
Interventions: PROCEDURE: Posteromedial Tibiofemoral Incongruence (PMTFI) Treatment by the means of published technique (reference nr 1).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole in Body Focused Repetitive Behaviors
Status: NOT_YET_RECRUITING
Conditions: Trichotillomania (Hair-Pulling Disorder)|Dermatillomania
Interventions: DRUG: Placebo|DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disposition of Eslicarbazepine Acetate and Its Metabolites S-licarbazepine and R-licarbazepine
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093|DRUG: S-licarbazepine|DRUG: R-licarbazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of 14-day Multiple Dose Titrations of TS-134 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TS-134|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Newly Formulated Tylenol Tablet (Acetaminophen) and Tylenol 8 Hour (H) Extended Release (ER) Tablet (Acetaminophen) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Benefits of Alcoholic Hangover Medicine
Status: NOT_YET_RECRUITING
Conditions: Gastrointestinal Microbiome
Interventions: DIETARY_SUPPLEMENT: Myrkl|DIETARY_SUPPLEMENT: dextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sofosbuvir/Velpatasvir Fixed-Dose Combination and Ribavirin for 12 or 24 Weeks in Participants With Chronic Genotype 1 or 2 Hepatitis C Virus Infection Who Have Previously Failed a Direct-Acting Antiviral-Containing Regimen
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: SOF/VEL|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Deep Wave Trabeculoplasty (DWT) in Primary Open Angle Glaucoma and Ocular Hypertension
Status: TERMINATED
Conditions: Primary Open-angle Glaucoma (POAG)|Ocular Hypertension (OHT)
Interventions: DEVICE: DWT device dose A|DEVICE: Ellex Tango SLT machine|DEVICE: DWT device dose B|DEVICE: DWT sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Survivin Long Peptide Vaccine in Treating Patients With Metastatic Neuroendocrine Tumors
Status: RECRUITING
Conditions: Lung Atypical Carcinoid Tumor|Lung Typical Carcinoid Tumor|Metastatic Pancreatic Neuroendocrine Tumor
Interventions: BIOLOGICAL: Incomplete Freund's Adjuvant|DRUG: Octreotide Acetate|BIOLOGICAL: Sargramostim|BIOLOGICAL: SVN53-67/M57-KLH Peptide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Immunological and Pharmacological Factors for Response to Adalimumab in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Adalimumab|OTHER: Healthy volunteers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of a Combined Surgical and Pharmacological Therapy to Treat Mixed Urinary Incontinence.
Status: COMPLETED
Conditions: Urinary Incontinence Mixed (Stress and Urge)
Interventions: PROCEDURE: TVT-O/Oxytrol|DEVICE: TVT-O|DRUG: Oxytrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Ways to Improve Medication Use Among People With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis
Interventions: BEHAVIORAL: Mailed education|BEHAVIORAL: Telephone coaching program for patients|BEHAVIORAL: Medication adherence alert program for doctors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitaliti Continuous Vital Signs Monitor User-Testing Protocol: VERDICT-2
Status: NOT_YET_RECRUITING
Conditions: Surgery
Interventions: OTHER: User-testing of Vitaliti Continuous Vital Sign Monitor Model CVSM-1A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: mDASHNa-CC APP to Support a Healthy Diet and Hypertension Control for Chinese Canadian Seniors
Status: UNKNOWN
Conditions: Hypertension|Diet, Healthy
Interventions: DEVICE: mDASHNa App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessing the Safety and Efficacy of AVX-012 in Subjects With Mild-to-moderate Dry Eye Syndrome
Status: UNKNOWN
Conditions: Dry Eye Syndrome
Interventions: DRUG: AVX012 Ophthalmic Solution Low dose|DRUG: AVX012 Ophthalmic Solution High dose|DRUG: Placebo (vehicle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Acidophilus for the Treatment and Prevention of Oral Candidiasis in Patients Undergoing Radiation Therapy
Status: COMPLETED
Conditions: Oral Candidiasis
Interventions: DIETARY_SUPPLEMENT: Acidophilus|DIETARY_SUPPLEMENT: Acidolphilus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Decitabine in Treating Patients With Symptomatic Myelofibrosis
Status: TERMINATED
Conditions: Chronic Myeloproliferative Disorders|Secondary Myelofibrosis
Interventions: DRUG: Dacogen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: QOLBET Quality Of Life in Patients With Early Relapsing-remitting Multiple Sclerosis Treated With BETaferon® in Korea
Status: WITHDRAWN
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Interferon beta 1-b (Betaferon/Betaseron, BAY86-5046)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fenofibrate Bioequivalence Study (0767-031)
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: fenofibrate (U.S. formulation)|DRUG: fenofibrate (UK formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes and Costs Associated With Initiating Maintenance Treatment With Fluticasone Propionate 250mcg/Salmeterol Xinafoate 50mcg Combination (FSC) Versus Anticholinergics Including Tiotropium (TIO) in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: fluticasone/salmeterol combination (FSC) 250/50mcg|DRUG: tiotropium|DRUG: ipratropium bromide alone or in fixed dose combination with albuterol
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electronic Urinary Flowmeter to Improve Accuracy of Bladder Diaries .
Status: RECRUITING
Conditions: Lower Urinary Tract Symptoms|Healthy
Interventions: DEVICE: Diary pod ( measuring vessel that automatically calculates voided volume)|DEVICE: Diary pod ( measuring vessel that automatically calculates voided volume)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Ketamine for Acute Postoperative Analgesia (KAPA) Trial
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ketamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of a Fluorescent Visualization System for Non-visible Lung Cancer Nodules
Status: RECRUITING
Conditions: Lung Cancer|Video-assisted Thoracic Surgery|EGFR|Cetuximab
Interventions: DRUG: Cetuximab-IRDye800
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REcurrent Stroke Prevention Through Personalized Education by Clinical Trainers (RESPPECT Trial)
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: BEHAVIORAL: Enhanced Stroke Education|BEHAVIORAL: Usual Stroke Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Herceptin (Trastuzumab) in Combination With Standard Chemotherapy in Patients With HER Positive Metastatic Gastric Cancer
Status: TERMINATED
Conditions: Gastric Cancer
Interventions: DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Bronchospasm Potentially Induced by HFO vs HFA MDI in Participants With Well/Partially Controlled Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: HFA MDI|DRUG: HFO MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Adalimumab in Patients With Erosive Osteoarthritis of the Interphalangeal Finger Joints
Status: COMPLETED
Conditions: Erosive Osteo-Arthritis
Interventions: DRUG: Adalimumab (40 mg sc every other week)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myofascial Release and Kinesio Taping on Autonomic Nervous System in Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Chronic Disease
Interventions: OTHER: Myofascial Soft Tissue Release|OTHER: Kinesio taping treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib, Pomalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Carfilzomib|DRUG: dexamethasone|DRUG: Daratumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Bacillus clausii|DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intensive Low Sodium Restriction on Glomerular Infiltration Rate in Chronic Kidney Disease
Status: UNKNOWN
Conditions: Declination of Glomerular Infiltration Rate in Chronic Kidney Disease Population
Interventions: BEHAVIORAL: Dietary Scanning Calculator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Drug Interaction Study of Danicopan
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Danicopan|DRUG: Warfarin|DRUG: Bupropion|DRUG: Ethinyl Estradiol/Norethindrone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: ECF843|OTHER: ECF843 vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-inferiority Trial on Treatments in Early COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Sotrovimab|DRUG: Tixagevimab Cilgavimab|DRUG: Nirmatrelvir Ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficacy & Safety of Tacrolimus With/Without MMF or Monoclonal Anti-IL2R Antibody in Liver Transplantation.
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Modified Pectoral Nerves Block Versus Serratus Plane Block in Major Breast Cancer Surgery
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine 0.25% with epinephrine|DRUG: Bupivacaine 0.25% with epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation Associated With Manual Therapy in Knee Ostearthritis Pain
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: TMS|OTHER: Manual therapy (MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm
Status: COMPLETED
Conditions: Trichuris Trichiura; Infection|Hookworm Infections
Interventions: DRUG: Emodepside
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DIAGNOSTIC_TEST: body plethysmography|DIAGNOSTIC_TEST: impulse oscillometry|DIAGNOSTIC_TEST: multiple breath washout
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Center Clean Air Randomized Controlled Trial in COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DEVICE: Air cleaner|DEVICE: Sham air cleaner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Lactobacillus Plantarum on Cortisol, IgA and Alpha-amylase Levels in Human Saliva During Stress
Status: COMPLETED
Conditions: Stress Reaction
Interventions: DIETARY_SUPPLEMENT: Probiotic (Lactobacillus Plantarum)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combined Supraclavicular Block and General Anesthesia in Pediatric Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: OTHER: general anesthesia only.|OTHER: general anesthesia plus supraclavicular block.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Determining the Effect of Two Different Methods in Children to Maintain Drain Patency After Cardiac Surgery
Status: COMPLETED
Conditions: Infant ALL|Congenital Heart Disease
Interventions: OTHER: Control|OTHER: Experimental Group (Absorption Group)|OTHER: Experimental Group (Milking Group)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improving Patient-Centered Care Delivery Among Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: BREATHE program|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypomagnesemia Associated With Proton-Pump Inhibitor Use
Status: COMPLETED
Conditions: Proton Pump Inhibitor Adverse Reaction|Hypomagnesemia|Arrhythmias, Cardiac|Seizures|Hypocalcemia|Hypokalemia
Interventions: DRUG: proton pump inhibitor use
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Sumatriptan With Naprosyn in Migraine With Aura
Status: UNKNOWN
Conditions: Migraine With Aura
Interventions: DRUG: sumatriptan with naprosyn|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Beta-blOckers discoNtinuation in Patients Presenting Heart FaIlure With REcovered Left Ventricular Ejection Fraction
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: DRUG: Βeta-Blockers discontinued (with tapering)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prehabilitation in Patients Suffering From Gynecological Cancers
Status: UNKNOWN
Conditions: Prehabilitation
Interventions: OTHER: bicycle ergometer training with different intensities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extended Pancreatic Neck Transection Versus Conventional Pancreatic Neck Transection During Laparoscopic Pancreaticoduodenectomy( LPDEXCEPT)
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Pancreaticoduodenectomy
Interventions: PROCEDURE: extended pancreatic neck transection during laparoscopic pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incremental Value of Point of Care H-FABP Testing in Primary Care Patients Suspected of Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Angina Pectoris, Unstable|Angina Pectoris, Stable|Thoracic Diseases
Interventions: DEVICE: heart type fatty acid binding protein testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Superficial Back Line Relaxation Technique on Hamstring Flexibility in Non Specific Low Back Pain Patients
Status: RECRUITING
Conditions: Low Back Pain, Mechanical|Hamstring Flexibility
Interventions: OTHER: Conventional physical therapy|OTHER: Superficial back line relaxation (SMIT & CCFE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Central Nervous System Neoplasm|Primary Central Nervous System Neoplasm
Interventions: BEHAVIORAL: Cogstate Assessment Battery|DRUG: Memantine|DRUG: Memantine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas
Status: COMPLETED
Conditions: Adult Malignant Fibrous Histiocytoma of Bone|Desmoid Tumor|Endometrial Cancer|Ovarian Cancer|Sarcoma|Small Intestine Cancer
Interventions: DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Accufuser Omnibus® (Elastomeric Infusion Pump); Comparative Clinical Trial
Status: COMPLETED
Conditions: Upper Gastrointestinal Cancer
Interventions: DEVICE: The domestic PCA equipment 'Accufuser Omnibus®'|DEVICE: Imported PCA equipment 'Infusor SV®, Baxter, USA'
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CARESSES Testing and Evaluation Phases
Status: UNKNOWN
Conditions: Aging
Interventions: DEVICE: Socially-assistive Pepper robot with a CARESSES cultural competence solution|DEVICE: Socially-assistive control Pepper robot with an alternative CARESSES solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Comparison Between Three Types of Prosthetic Feet
Status: COMPLETED
Conditions: Amputation; Traumatic, Leg, Lower, Between Knee and Ankle
Interventions: DEVICE: C-SACH|DEVICE: B-DER|DEVICE: A-DER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Vitamin C Supplement for Lumbar Spine Surgery
Status: UNKNOWN
Conditions: Lumbar Spine Surgery
Interventions: DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bowel Sensitivity Threshold in IBS Patients Versus in Healthy Controls Using the Novel Rapid Barostat Bag
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome|Visceral Hypersensitivity
Interventions: DEVICE: Rapid Barostat Bag|OTHER: IBS severity scoring system questionnaire (IBS-SSS)|OTHER: HAD scale questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients
Status: COMPLETED
Conditions: Burns|Growth Hormone Treatment
Interventions: DRUG: Somatropin|DRUG: 0.09% Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research Development13(RD13)-02 Cell Injection in Patients With Relapsed or Refractory Cluster Of Differentiation 7(CD7)-Positive Hematological Malignancies
Status: RECRUITING
Conditions: Neoplasms|Hematologic Neoplasms|Neoplasms by Site|Hematologic Diseases
Interventions: DRUG: RD13-02 cell infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Auriclosene (NVC-422) in the Treatment of Bacterial Conjunctivitis
Status: COMPLETED
Conditions: Bacterial Conjunctivitis
Interventions: DRUG: Auriclosene Solution 0.3%|DRUG: Auriclosene Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adebrelimab Plus Apatinib and Etoposide for the Treatment of HER2-Negative Breast Cancer Brain Metastasis
Status: NOT_YET_RECRUITING
Conditions: HER2-negative Breast Cancer Brain Metastases
Interventions: DRUG: Adebrelimab|DRUG: Apatinib|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Microalgae Extract Dietary Supplement on Gut Health, Anxiety, and Immune Function
Status: RECRUITING
Conditions: Gastrointestinal Problem|Anxiety|Stress|Gastrointestinal Symptoms
Interventions: DIETARY_SUPPLEMENT: Microalgae Extract Capsules|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Satisfaction of Limited English-Proficient Patients With Phone Interpretation Services Compared to In-Person Interpreters: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Pelvic Floor Disorders
Interventions: OTHER: Interpretation Modality: In Person|OTHER: Interpretation Modality: Telephonic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study in Healthy Males to Measure Maraviroc in Blood, Saliva, Seminal Fluid, and Rectal Tissue
Status: COMPLETED
Conditions: HIV/AIDS
Interventions: DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Correlation Study of PAI-1 4G/5G Polymorphism and Postoperative AKI in Patients With Aortic Dissection
Status: COMPLETED
Conditions: AKI - Acute Kidney Injury|PAI-1 4G/5G Polymorphism|Aortic Dissection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive Rehabilitation in Schizophrenia
Status: COMPLETED
Conditions: Cognitive Impairment|Schizophrenia
Interventions: BEHAVIORAL: Cognitive Rehabilitation Therapy (CRT) + Skill Training (SDG)|BEHAVIORAL: Individual Computer Based Cognitive Rehabilitation (ICBCR) and Skills Training (SDG)|BEHAVIORAL: Skills Group (SDG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: D-serine Monotherapy for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: D-serine|DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Regimens for Medical Abortion: Mifepristone+Misoprostol Versus Misoprostol Alone
Status: COMPLETED
Conditions: Pregnancy Termination
Interventions: DRUG: mifepristone|DRUG: misoprostol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application
Status: SUSPENDED
Conditions: Malignant Tumors|Positron-Emission Tomography
Interventions: DRUG: 68Ga-Fibroblast activation protein inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Systemic and Peritoneal Chemotherapy for Advanced Gastric Cancer
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer|Peritoneal Metastases|Chemotherapy Effect
Interventions: DRUG: Doxorubicin and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact on Postoperative Wellbeing in the Post-anaesthesia Care Anaesthesia (PACU) of Personalized Music and Beverages.
Status: COMPLETED
Conditions: Postoperative Complications|Postoperative Pain
Interventions: DEVICE: Music via internet and noise canceling headphones|OTHER: Beverages
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Controlled-release Paroxetine in Major Depressive Disorder (Double-blind, Placebo-controlled Study)
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: paroxetine IR 10mg tablet|DRUG: paroxetine IR 20mg tablet|DRUG: matched placebo to paroxetine IR 10mg or 20mg|DRUG: Paroxetine CR 12.5mg tablet|DRUG: Paroxetine CR 25mg tablet|DRUG: matched placebo to paroxetine CR 12.5mg or 25mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S0108 Bevacizumab in Treating Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Anaplastic Large Cell Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Mantle Cell Lymphoma
Interventions: BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of HRS-8080 in Combination With Dalpiciclib Isethionate Tablets in Patients With Unresectable or Metastatic Breast Cancer
Status: RECRUITING
Conditions: Unresectable or Metastatic Breast Cancer
Interventions: DRUG: HRS-8080; Dalpiciclib Isethionate Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Patients With HER2-Positive Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors|HER2-positive Breast Cancer
Interventions: DRUG: ZN-A-1041 50mg BID|DRUG: ZN-A-1041 100mg BID|DRUG: ZN-A-1041 200mg BID|DRUG: ZN-A-1041 400mg BID|DRUG: ZN-A-1041 600mg BID|DRUG: ZN-A-1041 800mg BID|DRUG: ZN-A-1041 1000mg BID|DRUG: ZN-A-1041 + T-DM1 3.6 mg/kg iv. for Phase1b|DRUG: ZN-A-1041 + T-Dxd 5.4 mg/kg iv. for Phase1b|DRUG: ZN-A-1041 + PHESGO / Herceptin plus Perjeta injection for Phase1b|DRUG: ZN-A-1041 + T-DM1 3.6 mg/kg iv. for Phase1c|DRUG: ZN-A-1041 + T-Dxd 5.4 mg/kg iv. for Phase1c|DRUG: ZN-A-1041 + PHESGO / Herceptin plus Perjeta injection for Phase1c
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Functional Performances Study of Two Synthetic Male Condom
Status: COMPLETED
Conditions: Functional Performance|Synthetic Male Condom
Interventions: DEVICE: (1) WONDALEAF-CAP, (2) WONDALEAF-ON-MEN, (3) durex-TOGETHER (active comparator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Barbed-suture Efficiency Study for Sacrocolpopexy
Status: RECRUITING
Conditions: Prolapse; Female
Interventions: PROCEDURE: Non-barbed delayed absorbable suture|PROCEDURE: Barbed delayed absorbable suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Sertraline|DRUG: Placebo|DRUG: BupropionXL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Phase 1 Cardiac Rehabilitation With and Without Lower Limb Paddling Effects in Post CABG Patients.
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: OTHER: Phase 1 Cardiac Rehabilitation|OTHER: Phase 1 Cardiac Rehabilitation with Lower Limb Paddling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Incentive Performance Study (DIPS) at Shanghai Jiading District
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Give incentives to physicians based on their patient's HbA1c improvement|BEHAVIORAL: Give incentives to patients based on their own HbA1c improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Proof-of-concept Study to Evaluate the Efficacy and Safety of Rozanolixizumab to Treat Adult Study Participants With Severe Fibromyalgia Syndrome
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DRUG: rozanolixizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Next Generation Advanced Insulin Delivery System in Adults With Diabetes and Advanced Renal Disease
Status: RECRUITING
Conditions: Dialysis|Chronic Kidney Disease|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1|Hemodialysis|Peritoneal Dialysis
Interventions: DEVICE: 2nd Generation Automated Insulin Delivery (AID) system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Abdominal Neoplasm|Malignant Pelvic Neoplasm|Recurrent Colon Carcinoma|Recurrent Desmoplastic Small Round Cell Tumor|Recurrent Fallopian Tube Carcinoma|Recurrent Gastric Carcinoma|Recurrent Liposarcoma|Recurrent Malignant Mesothelioma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Recurrent Rectal Carcinoma|Recurrent Rhabdomyosarcoma|Recurrent Sarcoma|Refractory Colon Carcinoma|Refractory Desmoplastic Small Round Cell Tumor|Refractory Fallopian Tube Carcinoma|Refractory Gastric Carcinoma|Refractory Liposarcoma|Refractory Malignant Mesothelioma|Refractory Ovarian Carcinoma|Refractory Primary Peritoneal Carcinoma|Refractory Rectal Carcinoma|Refractory Rhabdomyosarcoma|Refractory Sarcoma|Resectable Liposarcoma|Resectable Malignant Mesothelioma|Resectable Sarcoma
Interventions: DRUG: Cisplatin|PROCEDURE: Cytoreductive Surgery|DRUG: Doxorubicin|DRUG: Hyperthermic Intraperitoneal Chemotherapy|DRUG: Sodium Thiosulfate|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography|PROCEDURE: Biospecimen Collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Active Thermoregulation on the Microcirculation of Free Flaps
Status: COMPLETED
Conditions: Microcirculation|Thermoregulation|Free Flap
Interventions: DEVICE: Hilotherm Clinic®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gadolinium Retention in Human Bone Tissue in Pediatric Patients
Status: RECRUITING
Conditions: Gadolinium|MultiHance|Dotarem|Magnetic Resonance Imaging|Gadolinium Retention
Interventions: DRUG: Pre-operative MRI with Dotarem|DRUG: Pre-operative MRI with MultiHance|PROCEDURE: Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects With Amyotrophic Lateral Sclerosis (ALS) With Superoxide Dismutase Type 1 (SOD1) Gene Mutation
Status: NOT_YET_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: RAG-17|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT