pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Relation Between the Increase of Peripheral Edema by Fluid Therapy and the Decrease in Microcirculatory Vesseldensity
Status: COMPLETED
Conditions: Edema|Sepsis
Interventions: DEVICE: Videomicroscopy of the sublingual microcirculation|DEVICE: Bio-impedance measurements.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Azacitidine Compared to Conventional Chemotherapy as Consolidation of Elderly Patients With AML
Status: TERMINATED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacitidine|DRUG: DA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wood Smoke Interventions in Native American Populations
Status: COMPLETED
Conditions: Respiratory; Disorder, Functional, Impaired|Respiratory Infection Other
Interventions: BEHAVIORAL: Education (Tx1)|DEVICE: Air Filtration Unit Treatment (Tx2)|DEVICE: Placebo Intervention (Tx3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage
Status: TERMINATED
Conditions: Intraventricular Hemorrhage|Autoregulation
Interventions: OTHER: Hypercapnia|OTHER: Normocapnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Inferiority Comparison of Migrane® Versus Parcel ® For Treatment of Tensional Cephaleia
Status: WITHDRAWN
Conditions: Tensional-type Headache
Interventions: DRUG: MIGRANE|DRUG: PARCEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ketamine v. Ketorolac for Management of Generalized Tension Type Headache
Status: UNKNOWN
Conditions: Migraine
Interventions: DRUG: Intravenous ketamine|DRUG: Ketorolac|DRUG: Normal saline|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation in Central Neuropathic Pain
Status: COMPLETED
Conditions: Neuropathic Pain
Interventions: DEVICE: active rTMS then sham rTMS|DEVICE: sham rTMS then active rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simplified Algorithm for the Prevention of Postoperative Nausea and Vomiting in an Oncological Hospital
Status: COMPLETED
Conditions: Postoperative Nausea|Postoperative Vomiting
Interventions: DRUG: Droperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: RIAC - Registro Italiano Arresti Cardiaci (Italian Registry of Cardiac Arrest)
Status: UNKNOWN
Conditions: Out-Of-Hospital Cardiac Arrest|In-hospital Cardiac Arrest
Interventions: OTHER: Out-of-hospital cardiac arrest (OHCA)|OTHER: In-hospital cardiac arrest (IHCA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Supine Percutaneous Nephrolithotomy
Status: COMPLETED
Conditions: Renal Stone
Interventions: PROCEDURE: percutaneous nephrolithotomy (supine position)|PROCEDURE: percutaneous nephrolithotomy ( prone position)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness and Safety of Hybrid Coronary Revascularization
Status: RECRUITING
Conditions: Percutaneous Coronary Revascularization|Coronary Stenosis|Coronary Artery Disease Progression|Coronary Artery Bypass Grafting
Interventions: PROCEDURE: Hybrid Coronary Revascularization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pre-etching of Dentin Before Restorations With High Viscosity Glass Ionomer Cement
Status: WITHDRAWN
Conditions: Dental Caries
Interventions: PROCEDURE: HVGIC restoration with pre-etching|PROCEDURE: HVGIC restoration with non pre-etching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery Combined With Intensity Modulated Radiation Therapy - Image-Guided Radiation Therapy (IMRT-IGRT) in Locally-advanced Prostate Cancers
Status: COMPLETED
Conditions: Prostate Cancer|Prostate Adenocarcinoma
Interventions: PROCEDURE: Surgery combined with IMRT-IGRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Astegolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Population Pharmacokinetic-pharmacodynamic (PK-PD) Study of 9 Broad-Spectrum Anti-infective Agents in the Cerebro Spinal Fluid (CSF) of Brain Injured Patients With an External Ventricular Drainage (EVD).
Status: COMPLETED
Conditions: Infection
Interventions: OTHER: Blood and cerebrospinal fluid pharmacocinetic samples on one of the nine antibiotics prescribed in routine use
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Drug Levels of Deucravacitinib From Tablets After Oral Administration in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Deucravacitinib|DRUG: Famotidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study
Status: NOT_YET_RECRUITING
Conditions: Heavy Menstrual Bleeding|Bleeding Disorder|Von Willebrand Diseases
Interventions: DRUG: Levonorgestrel Intrauterine System|DRUG: Norethindrone Acetate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexamethasone for Pain After Shoulder Surgery
Status: COMPLETED
Conditions: Shoulder Impingement Syndrome|Arthritis
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Green Tea Extract: a Non-Surgical Alternative for Treatment of Uterine Fibroids
Status: TERMINATED
Conditions: Leiomyoma
Interventions: DIETARY_SUPPLEMENT: EGCG ( Green Tea extract)|DIETARY_SUPPLEMENT: Brown rice pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Clinical Evaluation of the Cinatra™ Corolimus-Eluting Coronary Stent in De Novo Lesions in Native Coronary Arteries
Status: TERMINATED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Cinatra™ Corolimus Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Simplified Treatment Monitoring for 8 Weeks Glecaprevir/Pibrentasvir in Chronic Hepatitis C Patients
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: glecaprevir (300mg)/pibrentasvir (120mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Women With Endometriosis
Status: UNKNOWN
Conditions: Subfertility
Interventions: DRUG: Merional|PROCEDURE: IUI|DRUG: Choriomon|DEVICE: shepherd catheter|PROCEDURE: Ovulation detection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electronic Consultation for AD/ADRD Residents Experiencing Infectious Diseases
Status: WITHDRAWN
Conditions: Alzheimer's Dementia|Nursing Homes|Antibiotics|Dementia
Interventions: DEVICE: eCARE-ID|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Radiotherapy Planning Using Fluciclovine PET in Patients With Newly Diagnosed Glioblastoma
Status: RECRUITING
Conditions: Newly Diagnosed Glioblastoma
Interventions: DRUG: Fluciclovine PET guided Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Causal Mechanisms in Adolescent Arterial Stiffness
Status: RECRUITING
Conditions: Lipid Disorder|Dyslipidemias|Aortic Stiffness|Insulin Resistance Syndrome|Metabolic Syndrome|Pediatric Obesity
Interventions: DIETARY_SUPPLEMENT: CS+|DIETARY_SUPPLEMENT: CS-
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quitting Schedule Mobile Smartphone Application in Helping Participants to Quit Smoking
Status: WITHDRAWN
Conditions: Cigarette Smoker|Current Every Day Smoker|Current Smoker|Malignant Neoplasm
Interventions: OTHER: Internet Mobile Technology|OTHER: Interview|OTHER: Questionnaire Administration|BEHAVIORAL: Smoking Cessation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate HMPL-306 in Patients With IDH1- and IDH2-mutated Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: HMPL-306 Regimen|DRUG: Salvage Chemotherapy Regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Window of Opportunity Study of Pre-operative Endocrine Therapy With and Without Prometrium in Postmenopausal Women With Early Stage Breast Hormone Receptor Positive (HR+) Human Epidermal Receptor 2 Negative (HER2-) Breast Cancer.
Status: RECRUITING
Conditions: Early-stage Breast Cancer|Hormone Receptor Positive Tumor
Interventions: DRUG: Letrozole|DRUG: Letrozole and Prometrium|DRUG: Tamoxifen and Prometrium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bleaching Effect of Solo and Combined Kiwi Extract and Ozone and Their Impact on Enamel
Status: NOT_YET_RECRUITING
Conditions: Discoloration, Tooth
Interventions: DEVICE: Bleaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Food Supplementation Delivered Conditionally vs Not Among Patients With Heart Failure
Status: RECRUITING
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Medically Tailored Meals Delivered Conditionally|DIETARY_SUPPLEMENT: Medically Tailored Meals Delivered Unconditionally|DIETARY_SUPPLEMENT: Produce Boxes delivered Conditionally|DIETARY_SUPPLEMENT: Produce Boxes Delivered Unconditionally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protein-Tyrosine Kinase Inhibitor (STI571) for Treatment of Patients With Ph+ Chronic Myeloid Leukemia in Accelerated and Blastic Phase
Status: COMPLETED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Imatinib (STI571)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Double-blind, Parallel Group, Placebo-Controlled Outpatient Trial of PD 00200390 in Adults With Nonrestorative Sleep
Status: COMPLETED
Conditions: Nonrestorative Sleep
Interventions: DRUG: PD 0200390|DRUG: PD 0200390|DRUG: PD 0200390|DRUG: PD 0200390|DRUG: PD 0200390|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Esmolol in Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: DRUG: Esmolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment of Relapsed or Refractory Neuroblastoma and Osteosarcoma With Expanded Haploidentical NK Cells and Hu14.18-IL2
Status: WITHDRAWN
Conditions: Neuroblastoma|Relapsed Neuroblastoma|Recurrent Neuroblastoma|Osteosarcoma
Interventions: BIOLOGICAL: Ex vivo Expanded and Activated Haploidentical Donor NK Cells|BIOLOGICAL: Hu14.18-IL2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety, Tolerability, and Efficacy of FLT3 CAR-T AMG 553 in FLT3-positive Relapsed/Refractory AML
Status: WITHDRAWN
Conditions: Relapsed/Refractory Acute Myeloid Leukemia
Interventions: DRUG: AMG 553
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teicoplanin-based Antimicrobial Therapy in Staphylococcus Aureus Bone and Joint Infection: Tolerance, Efficacy and Experience With Subcutaneous Administration
Status: COMPLETED
Conditions: Teicoplanin-based Antimicrobial Therapy|Staphylococcus Aureus|Bone and Joint Infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Remote Ischemic Preconditioning in Septic Patients
Status: RECRUITING
Conditions: Critically Ill|Acute Kidney Injury|Sepsis
Interventions: PROCEDURE: Remote ischemic preconditioning (RIPC)|PROCEDURE: Sham RIPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: JAB-21822|DRUG: Itraconazole|DRUG: Omeprazole|DRUG: Midazolam , Rosuvastatin calcium and digoxin|DRUG: Rifampicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Pneumatic Vitreolysis on Macular Hole
Status: COMPLETED
Conditions: Vitreomacular Traction (VMT)|Full-thickness Macular Holes (MH)
Interventions: DEVICE: Intraocular gas (C3F8)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Dosing Regimens of Clopidogrel Before Elective Percutaneous Coronary Intervention (PCI) on Platelet Function
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Clopidogrel|DRUG: Clopidogrel|DRUG: Clopidogrel|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Bowel Preparations Before Colonoscopy
Status: UNKNOWN
Conditions: Colorectal Neoplasms
Interventions: PROCEDURE: colonoscopy|PROCEDURE: colonoscopy|PROCEDURE: colonoscopy|PROCEDURE: colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle Disease
Status: RECRUITING
Conditions: Myopathy|Muscle Weakness|Muscle Damage|Muscle Spasticity|Muscle Cramp|Muscle Injury|Muscle Soreness|Muscle Atrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
Status: RECRUITING
Conditions: Major Depressive Disorder|Depression|Healthy
Interventions: DRUG: SP-624|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Traumeel®S Tablets on Exercise Induced Muscle Damage and Muscle Soreness
Status: COMPLETED
Conditions: Exercise-induced Muscle Soreness
Interventions: DRUG: Traumeel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ending the HIV Epidemic With Equity: an Intervention to Reduce the Impact of Racism and Discrimination
Status: RECRUITING
Conditions: Racism|Discrimination, Racial|Stigmatization|Hiv
Interventions: BEHAVIORAL: TRAncenDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Home-Based, Online, Mindfulness and Cognitive Training for Soldiers and Veterans With TBI
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury
Interventions: OTHER: Computerized Plasticity-Based Adaptive Cognitive Training|OTHER: Commercially available computerized training|OTHER: Mindfulness Training|OTHER: Traumatic Brain Injury Information Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: V710 First-In-Man (FIM) Study (V710-001)
Status: COMPLETED
Conditions: Staphylococcal Infections
Interventions: BIOLOGICAL: V710|BIOLOGICAL: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Prevalence of Hypercortisolism in Patients With Type 2 Diabetes and Treatment With Korlym® (Mifepristone) (CATALYST)
Status: RECRUITING
Conditions: Hypercortisolism|Diabetes Mellitus, Type 2
Interventions: DRUG: Mifepristone 300 MG [Korlym]|DRUG: Placebo for mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nab-Paclitaxel and Gemcitabine With or Without Olaratumab (LY3012207) in Participants With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Olaratumab|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: pegaspargase|DRUG: prednisolone|DRUG: teniposide|DRUG: thioguanine|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of the Life Expectancy of Patients With Metabolic Syndrome After Weight Loss:
Status: COMPLETED
Conditions: Obesity
Interventions: PROCEDURE: Laparoscopic one anastomosis gastric bypass|DIETARY_SUPPLEMENT: Hypocaloric diet therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Qualitative and Usability Evaluation of Advanced Technologies for Home Upper Limb Neurorehabilitation Post-stroke
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: DEVICE: H-Man Robot|DEVICE: ReHandyBot|DEVICE: MyoPanda
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Chemotherapy in Ovarian, Fallopian Tube and Peritoneal Carcinoma
Status: COMPLETED
Conditions: Primary Peritoneal Carcinoma|Ovarian Carcinoma|Fallopian Tube Carcinoma
Interventions: DRUG: neoadjuvant chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sleep Laboratory Study to Investigate the Safety and Efficacy of Neu-P11 in Primary Insomnia Patients
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: Neu-P11
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Prosthetic Management for Congenital Cleft Lip and Palate Infants on the Middle Ear Function
Status: COMPLETED
Conditions: Cleft Lip and Palate
Interventions: DEVICE: Feeding appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staphylococcus Aureus Caught in Action at the Site of Infection
Status: COMPLETED
Conditions: Staphylococcus (S.) Aureus Infection
Interventions: OTHER: data collection|DIAGNOSTIC_TEST: blood draw|DIAGNOSTIC_TEST: nose swabs|DIAGNOSTIC_TEST: Intraoperative tissue samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allogeneic Stem Cell Transplant After ATG, High-Dose Melphalan, and Fludarabine for Patients With Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: filgrastim|BIOLOGICAL: graft-versus-tumor induction therapy|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cyclosporine|DRUG: fludarabine phosphate|DRUG: melphalan|DRUG: methotrexate|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Metastatic Renal Cell Carcinoma Treated With Immunecheckpoint Inhibitors and Cytoreductive Nephrectomy
Status: NOT_YET_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: PROCEDURE: Cytoreductive Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single-Arm Study to Evaluate Administration of Lebrikizumab by Participants or Caregivers in the Home Setting
Status: WITHDRAWN
Conditions: Asthma
Interventions: DRUG: Lebrikizumab|DEVICE: Prefilled Syringes
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes
Status: TERMINATED
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Daily Step-based Exercise Using Fitness Monitors for Peripheral Artery Disease
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: BEHAVIORAL: Daily Step-based Exercise|BEHAVIORAL: Symptom-based Exercise|OTHER: Fitbit Fitness Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance Low Dose Oral Navelbine In Patients With Non Small Cell Lung Cancer - MA.NI.LA Trial
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Stage IIIB|Non-small Cell Lung Cancer Stage IV
Interventions: DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia
Status: NOT_YET_RECRUITING
Conditions: Laparotomy
Interventions: DRUG: Intravenous administered opioid|DRUG: Epidural administered opioid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Exenatide Monotherapy on Glucose Control in Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo 0.04 mL twice daily|DRUG: Placebo 0.04 mL once daily|DRUG: Placebo 0.08 mL once daily|DRUG: B - Exenatide 10 mcg twice daily|DRUG: C - Exenatide 10 mcg once daily|DRUG: Exenatide 20 mcg once daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Radicular Pain and Pain Modulation
Status: COMPLETED
Conditions: Back Pain|Back Pain With Radiation
Interventions: DIAGNOSTIC_TEST: Pressure pain assessment using computer controlled cuff algometry|DIAGNOSTIC_TEST: Temporal summation (TS)|DIAGNOSTIC_TEST: Conditioned pain modulation (CPM)|DIAGNOSTIC_TEST: Low back pain rating scale (LBPRS-pain)|DIAGNOSTIC_TEST: Oswestry Disability Index
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
Status: RECRUITING
Conditions: Semantic Dementia
Interventions: DRUG: Verdiperstat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MEDI3506 in Adult Subjects With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: MEDI3506|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of AEB071 Versus Tacrolimus in Combination With Mycophenolate Acid Sodium, Basiliximab and Steroids in Preventing Acute Rejection After Kidney Transplantation
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: AEB071
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects and Mechanism of the Fully Immersive Virtual Reality Cognitive Training Based on Leisure Activities
Status: NOT_YET_RECRUITING
Conditions: MCI|SCD
Interventions: BEHAVIORAL: VR cognitive training|BEHAVIORAL: Traditional cognitive training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: B-pVAC-SARS-CoV-2: Study to Prevent COVID-19 Infection in Adults With Bcell/ Antibody Deficiency
Status: COMPLETED
Conditions: Immune Deficiency Disease
Interventions: BIOLOGICAL: CoVAC-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiopulmonary Rehabilitation for Adolescents and Adults With Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease|Heart Defects, Congenital
Interventions: OTHER: Cardiopulmonary rehabilitation|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OCD Biomarker Survey Employing sEEG and Stimulation: The OBSESS Trial
Status: NOT_YET_RECRUITING
Conditions: Obsessive-Compulsive Disorder (OCD)
Interventions: DEVICE: Medtronic Percept RC neurostimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, & Immunogenicity of Multiple Formulations of BNT162b2 Against COVID-19 in Healthy Adults
Status: COMPLETED
Conditions: SARS-CoV-2 Infection|COVID-19
Interventions: BIOLOGICAL: BNT162b2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Nitrocamptothecin Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: rubitecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Alcohol Versus Chlorhexidine With and Without Water
Status: WITHDRAWN
Conditions: Infection
Interventions: OTHER: Chlorhexidine with water rinse|OTHER: Chlorhexidine without water rinse|OTHER: Chlorhexidine + sterillium hand rub
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Calcium With or Without Estrogen and/or Risedronate in Preventing Osteoporosis in Patients With Prostate Cancer
Status: COMPLETED
Conditions: Osteoporosis|Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: calcium carbonate|DIETARY_SUPPLEMENT: cholecalciferol|DRUG: Estrogen Antagonists|DRUG: risedronate sodium|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Concomitant Versus Hybrid Regimen for H. Pylori Eradication
Status: COMPLETED
Conditions: H.Pylori Infection|H.Pylori Gastrointestinal Disease|H. Pylori Associated Phlegmonous Gastritis
Interventions: DRUG: 10 day concomitant regimen|DRUG: 14 day hybrid regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Adjuvanted Inactivated Vaccine in Healthy Adults
Status: TERMINATED
Conditions: Covid19
Interventions: BIOLOGICAL: SARS-CoV-2 vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: UARK 2006-66, Total Therapy 3B: An Extension of UARK 2003-33 Total Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Velcade|DRUG: Thalidomide|DRUG: Dexamethasone|DRUG: Adriamycin|DRUG: Cisplatin|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DEVICE: Sudoscan®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Premature Ovarian Insufficiency
Status: RECRUITING
Conditions: Premature Ovarian Insufficiency
Interventions: PROCEDURE: Conventional IVF|PROCEDURE: Lower abdominal liposuction and preparation of SVF|PROCEDURE: Ovarian injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab
Status: COMPLETED
Conditions: Renal Transplant|Autoimmune Diseases
Interventions: DRUG: Rituximab 375|DRUG: rituximab 1000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Efficacy and Safety of Tisagenlecleucel in HR B-ALL EOC MRD Positive Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: CTL019
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Peak Airway Pressure and Gastric Insufflation in Pressure-Controlled Ventilation or Volume-Controlled Ventilation With I-Gel in Pediatric Patient
Status: COMPLETED
Conditions: Pediatric Urologic Surgeries
Interventions: OTHER: Pressure-controlled ventilation|OTHER: Volume-controlled ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Potential Drug-Drug Interaction Between Elafibranor and Indomethacin
Status: COMPLETED
Conditions: Drug-drug Interaction
Interventions: DRUG: elafibranor|DRUG: CHRONO-INDOCID
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vestibular Rehabilitation Verses Virtual Reality on Dizziness, Balance and Gait in Subacute Stroke
Status: COMPLETED
Conditions: Vestibular Rehabilitation
Interventions: OTHER: vestibular Training Group|OTHER: Virtual Reality Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Fetal, Obstetrics and Reproduction Genomics
Status: NOT_YET_RECRUITING
Conditions: Preeclampsia|Intrauterine Growth Restriction|Placental Disease
Interventions: DIAGNOSTIC_TEST: Doppler ultrasound|DIAGNOSTIC_TEST: Blood sample|DIAGNOSTIC_TEST: Blood sample|DIAGNOSTIC_TEST: Doppler ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Dental Treatment
Status: COMPLETED
Conditions: Anxiety|Postoperative Pain|Nausea
Interventions: DRUG: Fentanyl|DRUG: Dexmedetomidine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Plasma Ceramides on Peripheral Vascular Function
Status: RECRUITING
Conditions: Peripheral Vascular Disease|Lipid Disorder|Endothelial Dysfunction
Interventions: OTHER: High Saturated Fat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the EEG Connectivity Using Predominant Dexmedetomidine as Anesthetic in Fragile Brains
Status: UNKNOWN
Conditions: Aging Problems
Interventions: DRUG: Comparison MoCA test and EEG connectivity pre, intra and postoperative between groups P vs D-P
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Linear Stapler Versus Circular Stapler in Esophagojejunostomy
Status: RECRUITING
Conditions: Postoperative Complications|Operative Time|Hospital Costs
Interventions: DEVICE: Linear stapler|DEVICE: Circular stapler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Expectations in the Development of Intrusive Memories
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Positive Expectation Manipulation|BEHAVIORAL: Negative Expectation Manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Single and Multiple Oral Dose of TAK-418 in Healthy Female Participants
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-418|DRUG: TAK-418 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Continuous Infusion Piperacillin-tazobactam for the Treatment of Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: DRUG: Piperacillin-tazobactam combination product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized, Open-Label, Comparative Trial of Dideoxyinosine (ddI) Versus Dideoxycytidine (ddC) in HIV-Infected Patients Who Are Intolerant of or Who Have Failed Zidovudine (AZT) Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zalcitabine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Heart Failure and Sleep Apnea: Exercise Training and Continuous Positive Airway Pressure
Status: UNKNOWN
Conditions: Heart Failure|Sleep Apnea Syndromes
Interventions: OTHER: Exercise training|OTHER: CPAP group|OTHER: Exercise and CPAP group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Early Mobilization for Acute Ischemic Stroke Treated With Rt-PA or IA Thrombectomy
Status: COMPLETED
Conditions: Acute Ischemic Stroke
Interventions: BEHAVIORAL: standard early rehabilitation|BEHAVIORAL: adding early out-of-bed mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Mixed Meal Test for Diagnosis and Characterization and Type 3c Diabetes Mellitus Secondary to Pancreatic Cancer and Chronic Pancreatitis (DETECT)
Status: RECRUITING
Conditions: Pancreatic Cancer|Chronic Pancreatitis|Diabetes Mellitus Type 3c
Interventions: OTHER: Data Management and Monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Pharmacodynamics of SEL-212 (Pegsiticase + SEL-110) in Subjects With Elevated Blood Uric Acid Levels
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: SEL-110|BIOLOGICAL: SEL-212|BIOLOGICAL: SEL-037
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health Interventions to Prevent Heart Disease After Hypertensive Disorders of Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Hypertension in Pregnancy|Pre-Eclampsia|Eclampsia|Gestational Hypertension
Interventions: OTHER: Remote patient monitoring (RPM) system|OTHER: Mobile health application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation
Status: WITHDRAWN
Conditions: Atherosclerosis
Interventions: DRUG: Clopidogrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic GM-CSF Vaccine and Lenalidomide in Treating Myeloma Patients With Near Complete Remission
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide|BIOLOGICAL: Allogeneic Myeloma Vaccine|BIOLOGICAL: Prevnar-13
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Panobinostat (LBH589) in Patients With Refractory de Novo or Secondary Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Refractory Leukemia|Acute Myelogenous Leukemia
Interventions: DRUG: Panobinostat/LBH589
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest
Status: COMPLETED
Conditions: Out-of-hospital Cardiac Arrest
Interventions: OTHER: Rapid infusion of 2 liters of 4oC normal saline|DRUG: Rapid infusion of cold normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Pediatric Study of a Graft-VS.-Host Disease (GVHD) Prophylaxis Regimen With no Calcineurin Inhibitors After Day +60 Post First Allogeneic Hematopoietic Cell Transplant for Hematological Malignancies
Status: TERMINATED
Conditions: Hematologic Malignancy|Myeloid Malignancy
Interventions: DRUG: Ruxolitinib|DRUG: Mesna|DRUG: Anti-thymocyte globulin (ATG)|DRUG: Cyclosporine|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Methotrexate|RADIATION: Total Body Irradiation (radiation treatment)|DRUG: Bone marrow infusion|DRUG: Busulfan|DRUG: Thiotepa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short and Prolonged Conservative Treatment in Patients With Adhesive Intestinal Obstruction
Status: RECRUITING
Conditions: Small Bowel Obstruction|Small Bowel Adhesion
Interventions: PROCEDURE: Adhesiolysis|RADIATION: X-ray examination|PROCEDURE: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Chemoradiotherapy With Envafolimab For The Treatment of Locally Advanced Cervical Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: DRUG: Envafolimab|DRUG: Cisplatin|RADIATION: External Beam Radiotherapy (EBRT)|RADIATION: Brachytherapy (BT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Feasibility Study on the Use of F-18-FDG-PET and Optical Imaging in Evaluation of Radiation-induced Oral Mucositis
Status: TERMINATED
Conditions: Squamous Cell Carcinoma of the Oral Cavity|Oropharynx Metastases|Lymph Metastases
Interventions: PROCEDURE: endoscopic examination|PROCEDURE: FDG-PET
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ATr Inhibitor in Combination With Olaparib/Durvalumab (MEDI4736) in Gynaecological Cancers With ARId1A Loss or no Loss
Status: RECRUITING
Conditions: Gynaecological Cancers
Interventions: DRUG: Ceralasertib|DRUG: Olaparib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of GC1130A in Pediatric Patients With Sanfilippo Syndrome Type A (MPS IIIA)
Status: NOT_YET_RECRUITING
Conditions: Sanfilippo Syndrome Type A
Interventions: DRUG: GC1130A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of MRF for Characterization of Brain Tumors After Radiotherapy
Status: RECRUITING
Conditions: Brain Tumor|Brain Necrosis|Brain Metastases
Interventions: PROCEDURE: MRF in conjunction with IVIM MRI without contrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Milvexian|DRUG: Apixaban|DRUG: Placebo|DRUG: Apixaban Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of External Electrical Stimulating Applied on the Thigh in Men With Urinary Incontinence After Prostatectomy
Status: UNKNOWN
Conditions: Urinary Incontinence
Interventions: OTHER: ES and lifestyle advices|OTHER: Lifestyle advices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of a Fixed Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With High Blood Pressure Who do Not Achieve Target Blood Pressure Following Treatment With Azilsartan Medoxomil Alone
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Azilsartan medoxomil/placebo|DRUG: Azilsartan medoxomil - chlorthalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Blink Tears and Systane Concomitant With Restasis for the Treatment of Dry Eye Symptoms
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Cyclosporin A Restasis®|DRUG: Blink tears|DRUG: Systane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Menopausal Symptoms Probiotic Study
Status: NOT_YET_RECRUITING
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Gyntima Menopause|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Phase 1b Study of PD-0332991 in Combination With T-DM1(Trastuzumab-DM1)
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: PD-0332991 and T-DM1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT