pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Caries Detection With Two Different Caries Detecting Devices
Status: NOT_YET_RECRUITING
Conditions: Caries,Dental
Interventions: DEVICE: LumiCare rinse|DEVICE: QLF Inspektor Pro Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study on the Effectiveness and Safety of Coil System for Intracranial Aneurysm Embolization
Status: UNKNOWN
Conditions: Intracranial Aneurysm
Interventions: DEVICE: Coil embolization surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modafinil for the Treatment of Alcohol Use Disorders
Status: COMPLETED
Conditions: Alcohol Use Disorder
Interventions: DRUG: Modafinil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Strategies for Tailored Exercise to Prevent FallS
Status: ACTIVE_NOT_RECRUITING
Conditions: Falls|Fall Injury|Exercise Self-Efficacy|Falls Self-Efficacy
Interventions: BEHAVIORAL: eSTEPS CDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HighLife™ Transcatheter Mitral Valve Replacement System Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Mitral Valve Regurgitation|Mitral Valve Insufficiency
Interventions: DEVICE: Transcatheter Mitral Valve Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) of TKI258 in Cancer Patients With Normal and Impaired Hepatic Function
Status: COMPLETED
Conditions: Solid Tumors|Hepatic Impairment
Interventions: DRUG: Dovitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus
Interventions: DRUG: Atorvastatin 20 mg daily for 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine in Pediatric Tonsillectomy
Status: COMPLETED
Conditions: Pediatric Adenotonsillectomy|Post Operative Analgesia
Interventions: DRUG: Dexmedetomidine 0.75 mcg/kg|DRUG: Morphine 50 mcg/kg|DRUG: Morphine 100 mcg/kg|DRUG: Dexmedetomidine 1 mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin)
Status: COMPLETED
Conditions: Anemia, Iron-Deficiency|Kidney Failure, Chronic|Hemodialysis
Interventions: DRUG: Sodium ferric gluconate,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory stuDy of effectIveneSs and Safety of rivarOxaban in Patients With Left VEntricular Thrombus (R-DISSOLVE)
Status: COMPLETED
Conditions: Ventricular Mural Thrombosis
Interventions: DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Antiviral Effect, Safety, Tolerability and Pharmacokinetics of VH3739937 in in Treatment-Naive Adults Living With HIV-1
Status: NOT_YET_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: VH3739937|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Status: RECRUITING
Conditions: Drug Abuse|Nicotine Dependence
Interventions: DEVICE: MagPro X100 Magnetic Stimulator|DEVICE: Transcranial Rotating Magnetic Stimulator|DEVICE: Magnetom Prisma Fit 3T Scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon
Status: COMPLETED
Conditions: Colon Adenocarcinoma|Diarrhea
Interventions: DRUG: Antibiotics|DRUG: Bile Acid Binder
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of the LDL-C Lowering Effects of Ezetimibe Achieved in Co-administration Therapy With Statins in an Indonesian Population (Study P04276)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe|DRUG: statin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MEDA Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation for Stage IV Natural Killer/T-cell Lymphoma
Status: COMPLETED
Conditions: Extranodal NK-T-Cell Lymphoma, Nasal Type
Interventions: DRUG: MEDA|PROCEDURE: Auto-HSCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exercise Trial for Acute Myeloid Leukaemia (AML) Patients Undergoing Induction Chemotherapy
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: First-In-Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Escalating Single And Multiple Doses Of CSL040 In Healthy Subjects
Status: RECRUITING
Conditions: Complement Deficiencies
Interventions: DRUG: CSL040|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose IL 2 and Entinostat in RCC
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: DRUG: Entinostat|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Theta Connectivity in Working Memory
Status: RECRUITING
Conditions: Executive Function
Interventions: DEVICE: Theta-frequency near-zero phase lag stimulation|DEVICE: Theta-frequency anti-synchrony stimulation|DEVICE: Arrhythmic near-zero phase lag stimulation|DEVICE: Arrhythmic independent stimulation|DEVICE: Alpha-frequency near-zero phase lag stimulation|DEVICE: Alpha-frequency anti-synchrony stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TACE Combined With Methylcantharidimide Tablets in the Treatment of Large and Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: methylcantharidimide tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Of Newly-diagnosed Follicular Lymphoma With CELMoD Golcadomide, Rituximab +/- Nivolumab.
Status: RECRUITING
Conditions: Follicular Lymphoma Stage II|Follicular Lymphoma Stage III|Follicular Lymphoma Stage IV
Interventions: DRUG: golcadomide|DRUG: Nivolumab 10 MG/ML|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Off- Loading Shoe to Improve Healing and Prevention of Recurrence of Neuropathic Diabetic Plantar Foot Ulcers
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetic Neuropathic Foot Ulcer
Interventions: DEVICE: SANIDIAB|DEVICE: BAROUK
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vernakalant Versus Flecainide: Atrial Contractility
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DRUG: Vernakalant|DRUG: Flecainide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Early cART and cART in Combination With Autologous HIV-1 Specific Cytotoxic T Lymphocyte (CTL) Infusion in The Treatment of Acute HIV-1 Infected Adults
Status: UNKNOWN
Conditions: Acute HIV Infection
Interventions: DRUG: cART(TDF/AZT+3TC+LPV/r)|PROCEDURE: CTL infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluations of Optimizing Perioperative Fluid Management on Postoperative Pain Outcomes
Status: COMPLETED
Conditions: Patients Major Laminectomy Surgery
Interventions: PROCEDURE: SVV-guided fluid management|PROCEDURE: CVP-guided fluid management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Advanced Endoscopic Imaging in Colonoscopy
Status: UNKNOWN
Conditions: Polyps|Neoplasms
Interventions: DEVICE: Innovative colonoscopy (Olympus CF-HQ190L, NBI + Dual Focus)|DEVICE: Conventional colonoscopy (Olympus CF-H180DL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Surveillance Study to Assess the Safety of Flublok Quadrivalent (Influenza Vaccine) in Pregnant Women and Their Offspring
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Flublok Quadrivalent influenza vaccine RIV4|BIOLOGICAL: Standard-dose quadrivalent inactivated influenza vaccine SD-IIV4
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess the Effects of Mipomersen on Lipid and Lipoprotein Metabolism in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: mipomersen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression
Status: NOT_YET_RECRUITING
Conditions: Unipolar Depression|Bipolar Disorder
Interventions: DEVICE: Active rTMS over the left DLPFC and over the left DMPFC|DEVICE: Active rTMS over the left DLPFC|DEVICE: Sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetic, Pharmacodynamic Study of LAPS-IFNa in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: HM10660A|BIOLOGICAL: HM10660A placebo|BIOLOGICAL: Pegasys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Compare U0267 Against Vehicle in Subjects With Plaque-type Psoriasis Two of Two Phase 3 Studies
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: U0267 Foam|DRUG: Vehicle foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractional Photothermolysis for Treating Melasma
Status: COMPLETED
Conditions: Melasma
Interventions: DEVICE: Non-ablative fractional photothermolysis laser|OTHER: broad-spectrum sunblock (SPF 50+)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MOVIPREP® Versus PICOLAX® Pilot Study
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: macrogol3350 NA sulphate NACL KCL ascorbic acid NA ascorbate|DRUG: NA picosulfate magnesium citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Using Ultrasound Elastography to Predict Development of SOS
Status: COMPLETED
Conditions: Sinusoidal Obstruction Syndrome|Complications of Bone Marrow Transplant
Interventions: DIAGNOSTIC_TEST: shear wave ultrasound elastography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: NGS vs Culture Outcomes for Treatment of PJI
Status: ENROLLING_BY_INVITATION
Conditions: Prosthetic Joint Infection
Interventions: DIAGNOSTIC_TEST: Culture-based treatment|DIAGNOSTIC_TEST: Next Generation Sequencing (NGS) with Culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Air Optix Extended Wear Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Lotrafilcon B spherical soft contact lenses|DEVICE: Lotrafilcon B spherical soft contact lenses with comfort additive|DEVICE: Lotrafilcon B toric soft contact lenses with comfort additive|DEVICE: Comfilcon A spherical soft contact lenses|DEVICE: Comfilcon A toric soft contact lenses
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Full Pulpotomy in Mature Teeth With Symptomatic Irreversible Pulpitis as a Routine Treatment in the Primary Care Clinics
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: PROCEDURE: Full pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Microarchitecture in Men With Hemophilia
Status: TERMINATED
Conditions: Severe Hemophilia A|Osteoporosis
Interventions: RADIATION: HR-pQCT|BIOLOGICAL: Blood sample|RADIATION: Dual energy X-ray absorptiometry|OTHER: medical data collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness of Dry Needling in Patients With Chronic Nonspecific Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain
Interventions: OTHER: dry needling|OTHER: sham (placebo) dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess Efficacy, Immune Response & Safety of 2 Doses of Oral Live Attenuated HRV Vaccine at Different Viral Concentrations in Healthy Infants
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Rotarix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: GARDIAN, Gadovist in Routine Diagnostic Magnetic Resonance Imaging Administration in Non-selected Patients
Status: COMPLETED
Conditions: Magnetic Resonance Imaging|Magnetic Resonance Angiography
Interventions: DRUG: Gadobutrol (Gadovist, BAY86-4875)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Lapaquistat Acetate Co-Administered With Current Lipid-Lowering Treatment on Blood Cholesterol Levels in Subjects With Homozygous Familial Hypercholesterolemia
Status: TERMINATED
Conditions: Hypercholesterolemia
Interventions: DRUG: Lapaquistat acetate and current lipid-lowering treatment|DRUG: Current lipid-lowering treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Placebo-controlled Trial of Ferric Carboxymaltose in RLS Patients With Iron-deficiency Anemia
Status: TERMINATED
Conditions: Restless Legs Syndrome (RLS)
Interventions: DRUG: Injectafer® (Ferric Carboxymaltose - FCM)|DRUG: Placebo (Normal Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bispectral Index and End-Tidal Anesthetic Gas Concentration in Pediatric Patients
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: BIS Complete Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Serratus Anterior Plane Block to Prevent Chronic Postoperative Pain in Breast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms|Pain, Postoperative|Pain, Chronic|Post-Mastectomy Chronic Pain Syndrome
Interventions: PROCEDURE: Serratus Anterior Plane Block with local anesthetic|PROCEDURE: Serratus Anterior Plane Block with saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Flaxseed Modulates Inflammation and Oxidative Stress in CF
Status: COMPLETED
Conditions: Cystic Fibrosis|Oxidative Stress|Inflammation
Interventions: DIETARY_SUPPLEMENT: finely ground flaxseed powder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: VRC 605: Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), Administered Intravenously or Subcutaneously to Healthy Adults
Status: COMPLETED
Conditions: HIV Prevention
Interventions: BIOLOGICAL: VRC-HIVMAB075-00-AB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Protein Nutrition During Weight Loss
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Pulse casein feeding during energy restriction|DIETARY_SUPPLEMENT: Spread casein feeding during energy restriction|DIETARY_SUPPLEMENT: Pulse milk soluble protein feeding during energy restriction|DIETARY_SUPPLEMENT: Spread milk soluble protein feeding during energy restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Determine the Safety, Tolerability, and Efficacy of SHR-1209 in Patients With Familial Hypercholesterolemia
Status: UNKNOWN
Conditions: Familial Hypercholesterolemia
Interventions: DRUG: SHR-1209
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: capecitabine|DRUG: irinotecan hydrochloride|PROCEDURE: neoadjuvant therapy|PROCEDURE: therapeutic conventional surgery|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Effect of Tranexamic Acid Administered to Patients With Hip Fractures. Can Blood Loss be Reduced?
Status: TERMINATED
Conditions: Hip Fracture|Anemia
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotinic Receptors and Schizophrenia
Status: WITHDRAWN
Conditions: Schizophrenia
Interventions: DRUG: Risperidone plus Placebo|DRUG: Risperidone plus DMXB-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical and Radiographic Outcomes of SMART Technique vs ART in Primary Molars
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: Atraumatic Restorative Technique (ART)|PROCEDURE: SMART Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Clinical Study of SHR6390 and SHR1020 in the Treatment of Esophageal Squamous Cell Carcinoma After Progression on PD-1 Antibody
Status: UNKNOWN
Conditions: Esophageal Squamous Cell Carcinoma|Progression to PD-1 Antibody
Interventions: DRUG: SHR-6390|DRUG: SHR-6390 + Camrelizumab (SHR-1210)|DRUG: Camrelizumab (SHR-1210) + SHR-1020
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ischemic Time and Extent of Myocardial Infarction (MI) With Cardiac Magnetic Resonance Imaging (CMRI) in Patients With ST Elevation Myocardial Infarction (STEMI) and Primary Percutaneous Coronary Intervention (PCI) Study
Status: UNKNOWN
Conditions: Acute Myocardial Infarction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 8 Weeks of L-CIT Supplementation and LIRET on Vascular Function in Hypertensive Postmenopausal Women
Status: COMPLETED
Conditions: Hypertension|Menopause
Interventions: DIETARY_SUPPLEMENT: L-Citrulline|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Botulinum Toxin A Injections in Patients With Fowler's Syndrome
Status: COMPLETED
Conditions: Urinary Retention|Fowler's Syndrome
Interventions: DRUG: onabotulinumtoxinA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor
Status: UNKNOWN
Conditions: Tremor, Essential|Neurologic Manifestations|Tremor
Interventions: DEVICE: ExAblate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Cervical Pessary vs. Vaginal Progesterone for Preventing Premature Birth in IVF Twin Pregnancies
Status: COMPLETED
Conditions: Pregnancy
Interventions: DEVICE: Cervical pessary|DRUG: Vaginal progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Different Investigations Used in Intraocular Lens Calculation in High Myopic Cataractous Patients
Status: UNKNOWN
Conditions: Calculation of Intraocular Lens in High Myopic Cataractous Patients
Interventions: DEVICE: optical biometry|DEVICE: ultrasonic biometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison KS Versus TS
Status: NOT_YET_RECRUITING
Conditions: Dental Implant|Dental Implant-Abutment Design
Interventions: DEVICE: Implant placement TS III|DEVICE: Implant placement ks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lipids, Inflammation, and CV Risk in RA
Status: COMPLETED
Conditions: Rheumatoid Arthritis|Cardiovascular Disease
Interventions: DRUG: certolizumab|RADIATION: Stress myocardial perfusion PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Cervical Vagus Nerve Block Prevents Ocularvagal Reflex
Status: UNKNOWN
Conditions: Reflex, Oculocardiac
Interventions: PROCEDURE: Ultrasound guided vagus nerve block|DRUG: Bradycardia Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postoperative Pain Management in Laparoscopic Cholecystectomies
Status: ACTIVE_NOT_RECRUITING
Conditions: Postoperative Pain|Regional Anesthesia
Interventions: PROCEDURE: unilateral external oblique intercostal plane block group|PROCEDURE: unilateral oblique subcostal transversus abdomınıs plane block group|PROCEDURE: Local anesthetic infiltration group|DRUG: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Investigate the Effect of Water-soluble Tomato Extract on TMAO
Status: COMPLETED
Conditions: Cardiovascular Risk Factor
Interventions: DIETARY_SUPPLEMENT: FruitFlow|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Cefepime-tazobactam (FEP-TAZ) in Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)
Status: NOT_YET_RECRUITING
Conditions: Complicated Urinary Tract Infection|Acute Pyelonephritis
Interventions: DRUG: WCK 4282 (FEP-TAZ) 4 g|DRUG: Meropenem|DRUG: ciprofloxacin 500 mg Optional Oral Switch|OTHER: Infusion of normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-habilitation to Improve Outcomes in Patients Undergoing Liver Resection for Cancer
Status: UNKNOWN
Conditions: Colorectal Neoplasm|Biliary Tract Neoplasm|Liver Neoplasm
Interventions: DIETARY_SUPPLEMENT: Whey protein and dietary supplements|OTHER: prehab exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioactive Glass and Platelet Rich Fibrin in Intrabony Defects
Status: COMPLETED
Conditions: Periodontal Diseases|Bone Resorption
Interventions: DRUG: Platelet rich fibrin|DRUG: Bioactive Glass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of CPAP With and Without Humidification: A Pilot Study
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: ThermoSmart|DEVICE: Without ThermoSmart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bioequivalence Study of Oral Suspension and Intravenous Formulation of Edaravone in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Adult Subjects
Interventions: DRUG: MT-1186|DRUG: MCI-186
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Motorized Mechanical Massage Associated With Cosmetics in Improving Body Contour and Appearance of Gynoid Lipodystrophy
Status: UNKNOWN
Conditions: Cellulitis of Leg
Interventions: DEVICE: Motorized mechanical massage with the Dermothonus Slim® Ibramed with cosmetics
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prolonged Overnight Fast, Energy Metabolism and Skeletal Muscle Anabolic Sensitivity
Status: ACTIVE_NOT_RECRUITING
Conditions: Time Restricted Feeding
Interventions: OTHER: Short 10hr fast|OTHER: Long 16h fast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Occlusive Dressing vs Palmar Pedicular Island Flap in Fingertip Amputation
Status: UNKNOWN
Conditions: Finger Injuries
Interventions: PROCEDURE: coverage of the fingertips with bipedicled palmar island flap|OTHER: occlusive dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effectiveness of Kinesio Taping in Violin Players
Status: COMPLETED
Conditions: Pain, Neck|Pain, Joint|Pain, Shoulder|Occupational Diseases|Musculoskeletal Pain
Interventions: OTHER: Therapeutic tape|OTHER: Placebo tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact Of Core Stability Exercises On Standing , Functional Balance And Gait In Diplegic Cerebral Palsy Children
Status: NOT_YET_RECRUITING
Conditions: Diplegic Cerebral Palsy With Spasticity
Interventions: OTHER: Core stability exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL
Status: COMPLETED
Conditions: Refractory Acute Lymphoblastic Leukemia|Relapsed Acute Lymphoblastic Leukemia
Interventions: DRUG: Pevonedistat|DRUG: Vincristine|DRUG: Dexamethasone|DRUG: PEG-asparaginase|DRUG: Doxorubicin|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacovigilance Assessment of Reporting of Cardiovascular Adverse Events With Antineoplastic Agents (PARCA)
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Cardiac Diseases|Vascular Diseases|Cancer
Interventions: DRUG: Antineoplastic Agents
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Interleukin 11, Thrombocytopenia, Imatinib in Chronic Myelogenous Leukemia (CML) Patients
Status: COMPLETED
Conditions: Leukemia|Chronic Myelogenous Leukemia|Chronic Myeloid Leukemia
Interventions: DRUG: Interleukin-11 (IL-11 or Neumega)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ASP1570 Taken by Itself or With Pembrolizumab in Adults With Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: ASP1570|DRUG: pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Anti-CD1a CAR-T in the Treatment of R/R Acute T-lymphoblastic Leukemia/Lymphoblastic Lymphoma
Status: RECRUITING
Conditions: Acute T-lymphoblastic Leukemia|Acute T-lymphoblastic Lymphoma
Interventions: BIOLOGICAL: CAR-T Cell Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatment of Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Sintilimab Combined with Platinum-containing Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Quality of Life and Survival With MS-20 in Patient With Advanced Hepatocellular Carcinoma (FDA IND 74572)
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: MS-20|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Travelers' Diarrhea (TD) Vaccine Pivotal Efficacy Study
Status: COMPLETED
Conditions: Travelers' Diarrhea
Interventions: BIOLOGICAL: TD Vaccine System|BIOLOGICAL: TD Vaccine System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of KHK7791 in Hyperphosphatemia Patients on Hemodialysis
Status: COMPLETED
Conditions: Hyperphosphatemia
Interventions: DRUG: KHK7791|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Dry-lab Laparoscopic Training and Robotic Virtual Simulator
Status: RECRUITING
Conditions: Surgery
Interventions: DEVICE: da Vinci Simulator|DEVICE: Laparascopic training box
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced, Persistent, or Recurrent Endometrial Cancer
Interventions: DRUG: Everolimus|DRUG: Tamoxifen|DRUG: Letrozole|DRUG: Medroxyprogesterone Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
Status: RECRUITING
Conditions: Tibia Fracture
Interventions: DRUG: Ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Olfactory Training for Olfactory Dysfunction After Coronavirus Disease - 19 (COVID-19)
Status: UNKNOWN
Conditions: Covid19|SARS-CoV Infection|Olfactory Disorder|Anosmia
Interventions: OTHER: Essence oils
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Horizontal Whole-body Vibration Therapy in Post-menopausal Women
Status: COMPLETED
Conditions: Osteoporosis|Whole Body Vibration
Interventions: DEVICE: Whole Body Vibration and Infrared Therapy|DEVICE: Infrared Therapy|OTHER: Classical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Characterize Profile of Participant With Psoriatic Arthritis Depending on Whether Their Disease is Managed by a Dermatologist or by a Rheumatologist, and Starting Ustekinumab
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Ustekinumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Recruitment Maneuvers Plus Optimal PEEP Versus Optimal PEEP Alone in One Lung Ventilation
Status: COMPLETED
Conditions: Mechanical Ventilation Complication
Interventions: PROCEDURE: Recruitment manoeuvers|PROCEDURE: incremental PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Hand Movements in Kids With One-Sided Arm Stiffness Cerebral Palsy Through Motion Minder Therapy (MoMT)
Status: RECRUITING
Conditions: Cerebral Palsy Spastic Hemiplegic
Interventions: OTHER: Motion Minder Therapy (MoMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Behavioural Economic Intervention for Smoking Cessation
Status: RECRUITING
Conditions: Tobacco Smoking
Interventions: BEHAVIORAL: Brief cessation advice|BEHAVIORAL: Opt-out active referral|BEHAVIORAL: Behavioral economic mobile messaging|BEHAVIORAL: Opt-in active referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastric Emptying of Rice With Different Starch Properties
Status: COMPLETED
Conditions: Appetitive Behavior
Interventions: OTHER: White rice, low amylose|OTHER: White rice, high amylose|OTHER: White rice, slow|OTHER: White rice, resistant|OTHER: Brown rice, low amylose|OTHER: Brown rice, high amylose|OTHER: Fructooligosaccharide (FOS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation Of Patients With Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) Based on Nonlinear Analysis Of Respiratory Signals
Status: COMPLETED
Conditions: Obstructive Sleep Apnea Syndrome (OSAS)
Interventions: DEVICE: Estimation of nonlinear indices from Polysomnography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Ketorolac|DRUG: Pregabalin|DRUG: Placebo oral capsule|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Older People|Carbon Ion Radiotherapy|Radiotherapy Side Effect
Interventions: RADIATION: carbon ion radiotherapy|OTHER: targeted therapy|OTHER: single regimen chemotherapy in sequence with radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis of Acute Myocardial Infarction: Impact of an Educational and Organizational Intervention
Status: UNKNOWN
Conditions: STEMI|Myocardial Infarction|Nurses|Education|Emergency Room
Interventions: OTHER: Educational and organizational intervention|OTHER: Common Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cervical Spine Biomechanics During Endotracheal Intubation
Status: COMPLETED
Conditions: Spinal Diseases|Other Biomechanical Lesions of Cervical Region|Tracheal Intubation Morbidity
Interventions: PROCEDURE: Endotracheal intubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: To Evaluate the Safety and Efficacy of STSG-0002 Injection in Patients With Chronic Hepatitis B
Status: TERMINATED
Conditions: Chronic Hepatitis b
Interventions: DRUG: STSG-0002 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Molecular Diagnosis of Allergic Contact Dermatitis (SMECA).
Status: RECRUITING
Conditions: Eczema|Allergic Contact Eczema Nos
Interventions: PROCEDURE: Blood sample|PROCEDURE: Skin biopsies|PROCEDURE: ROAT test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: Dronedarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital
Status: WITHDRAWN
Conditions: Agitation
Interventions: DRUG: Ketamine|DRUG: Haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serum Rennin Kinetics Versus Serum Lactate Kinetics as Predictors of Mortality in Septic Shock Patients
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DIAGNOSTIC_TEST: Plasma renin concentrations will be measured at enrollment and at 24, 48, and 72 hours. Whole blood lactate measurements will be performed according to normal standard of care.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Efficacy and Safety of HLX03 in Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: HLX03|DRUG: adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A 4-month Intervention of Antioxidant Supplementation in Overweight Children
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Vitamin C Vitamin E Selenvital all from Burgerstein Vitamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Osimertinib Combined With Bevacizumab in Patients With Brain Metastasis Epidermal Growth Factor Receptor (EGFR) Mutation Positive Metastatic Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: osimertinib oral and bevazizumab intravenously
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clamp-crush Technique Versus Harmonic Scalpel in Living Donor Hepatectomy
Status: COMPLETED
Conditions: Hepatic Transplantation
Interventions: DEVICE: Harmonic scalpel|DEVICE: Kelly clamp crush technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lean Seafood Intake and Postprandial Metabolism
Status: COMPLETED
Conditions: Hyperlipidemias|Nutritional and Metabolic Diseases|Nutrition Disorders|Metabolic Diseases|Glucose Metabolism Disorders
Interventions: DIETARY_SUPPLEMENT: Lean seafood|DIETARY_SUPPLEMENT: Meat, egg, milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET Scan in Treating Patients With Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: positron emission tomography|RADIATION: fludeoxyglucose F 18|RADIATION: methionine C 11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Preoperative Embolization of Hypervascular Head and Neck Tumors to Improve Surgical Outcomes
Status: WITHDRAWN
Conditions: Malignant Neoplasm in the Head and Neck|Metastatic Malignant Neoplasm in the Head and Neck
Interventions: OTHER: Iodixanol|PROCEDURE: Angiogram|PROCEDURE: Arterial Embolization|DRUG: Polyvinyl Alcohol|DRUG: Ethiodized Oil|PROCEDURE: Computed Tomography|OTHER: Chart Abstraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Thalidomide Followed By Radical Retropubic Prostatectomy In Select Patients With Locally Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn More About the Safety and the Blood Level of BAY1747846 Given as Injection Into the Vein at Increasing Single Doses in Chinese Healthy Male Participants
Status: COMPLETED
Conditions: Contrast Enhancement in Magnetic Resonance Imaging|Healthy Volunteers
Interventions: DRUG: Gadoquatrane (BAY1747846) 0.03 mmol Gd/kg|DRUG: Gadoquatrane (BAY1747846) 0.1 mmol Gd/kg|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Study of the Effects of Canagliflozin on Plasma Volume in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Plasma Volume
Interventions: DRUG: Canagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extracorporeal Shock Wave Lithotripsy and Endotherapy for Pain in Chronic Pancreatitis
Status: COMPLETED
Conditions: Chronic Pancreatitis|Chronic Pain
Interventions: PROCEDURE: ESWL|PROCEDURE: ERCP|PROCEDURE: Sham ESWL|PROCEDURE: Sham ERCP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Visual Outcomes and Patient Satisfaction With Implantation of the Clareon Monofocal IOL With the New Clareon Manual Monarch IV IOL Delivery System
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Clareon monofocal Intraocular lens (toric and non-toric models)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of TRK-950 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Solid Carcinomas|Colon Cancer|Cholangiocarcinoma
Interventions: BIOLOGICAL: TRK-950|BIOLOGICAL: TRK-950|BIOLOGICAL: TRK-950
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: 3-dimensional conformal accelerated partial breast irradiation|RADIATION: brachytherapy|RADIATION: whole breast irradiation|RADIATION: MammoSite or other single-entry intracavitary device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth
Status: RECRUITING
Conditions: Pelvic Floor Disorders|Obstetric Trauma|Urinary Incontinence|Anal Incontinence|Pelvic Organ Prolapse|Pelvic Pain|Sexual Dysfunction|Constipation|Anal Sphincter Injury
Interventions: DIAGNOSTIC_TEST: Questionnaire|DIAGNOSTIC_TEST: Pelvic floor ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC