pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effect of Pilates Application on Abdominal Muscle Function, Core Stability, Musculoskeletal Pain, Quality of Life, Anxiety and Depression in Parkinson's Patients
Status: UNKNOWN
Conditions: Parkinson Disease|Pilates|Muscle Function
Interventions: OTHER: Pilates Exercises|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Open Angle Glaucoma
Status: COMPLETED
Conditions: Open-Angle Glaucoma
Interventions: DEVICE: iStent plus Cataract Surgery|PROCEDURE: Cataract surgery only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Tolerability of Nitric Oxide (NO) Via Inhalation to Subjects With Bronchiolitis
Status: COMPLETED
Conditions: Bronchiolitis
Interventions: DRUG: Nitric Oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DRUG: Telmisartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Subcutaneous Mircera for the Treatment of Anemia in Pre-Dialysis Participants With Chronic Kidney Disease.
Status: TERMINATED
Conditions: Anemia
Interventions: DRUG: Methoxy Polyethylene Glycol-epoetin Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety Tolerability & Efficacy of Kyprolis (Carfilzomib) in Relapsed or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed Refractory Multiple Myeloma
Interventions: DRUG: Drug: Carfilzomib + Dexamethasone|DRUG: Drug: Carfilzomib + Lenalidomide + Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Adjusted EPOCH Regimen in Combination With Ofatumumab or Rituximab in Treating Patients With Newly Diagnosed or Relapsed or Refractory Burkitt Lymphoma or Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: AIDS-Related Burkitt Lymphoma|Atypical Burkitt/Burkitt-Like Lymphoma|High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Recurrent Acute Lymphoblastic Leukemia|Recurrent Burkitt Lymphoma|Refractory Acute Lymphoblastic Leukemia|Refractory Burkitt Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin Hydrochloride|DRUG: Etoposide|BIOLOGICAL: Ofatumumab|DRUG: Prednisone|BIOLOGICAL: Rituximab|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Two-Part Phase 1 Study to Investigate the Safety and Tolerability of Supratherapeutic Dose of Zanubrutinib and Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: BGB-3111|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Inspiratory Muscle Training on Postural Stability, Balance, Pulmonary Function and Functional Capacity in Children With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Conventional chest physiotherapy|OTHER: Inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Passive Shoulder Exoskeleton and Muscle Fatigue on Occupational Work Performance
Status: UNKNOWN
Conditions: Fatigue|Muscle Strain|Physical Stress
Interventions: DEVICE: Passive shoulder exoskeleton|BEHAVIORAL: Fatigue protocol|DEVICE: No exoskeleton support|BEHAVIORAL: No peripheral fatiguing protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Ig NextGen 10% in Patients With Primary Immune Deficiency (PID)
Status: COMPLETED
Conditions: Primary Immune Deficiency (PID)
Interventions: DRUG: IntragamP|DRUG: Ig NextGen 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Pain and the Memory of Pain on Autonomic and Neuromuscular Function
Status: UNKNOWN
Conditions: Pain
Interventions: PROCEDURE: Experimental Noxious Stimulus|BEHAVIORAL: Memory of Experimental Noxious Stimulus|BEHAVIORAL: Memory of Prior Significant Injury|PROCEDURE: Mental Challenge Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Feasibility and Potential Aids of Intra-operative Endo-vaginal Ultrasound When Performing Rectal Shaving for Endometriosis
Status: NOT_YET_RECRUITING
Conditions: Endometriosis
Interventions: PROCEDURE: Endovaginal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web Based Intervention to Reduce Weight Bias Among Dietitians
Status: COMPLETED
Conditions: Intervention Video (I)|Weight Control Video (C1)|Weight Neutral Control Video (C2)
Interventions: OTHER: Online Educational Videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison Airway Devices in Nasotracheal Intubation in Manikin
Status: COMPLETED
Conditions: Nasotracheal Intubation
Interventions: DEVICE: Macintosh laryngoscope, Airtraq NT, Mcgrath laryngoscope|DEVICE: Macintosh laryngoscope|DEVICE: McGrath|DEVICE: Airtraq Nasotracheal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: 177Lu-PSMA-617 Therapy and Olaparib in Patients With Metastatic Castration Resistant Prostate Cancer
Status: RECRUITING
Conditions: Metastatic Castration Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: Olaparib|COMBINATION_PRODUCT: 177Lu-PSMA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Using Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes (TIL) in Metastatic Melanomas
Status: TERMINATED
Conditions: Metastatic Melanoma
Interventions: BIOLOGICAL: Tumor Infiltrating Lymphocytes (TIL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-Site Study of MDMA-Assisted Psychotherapy for Eating Disorders
Status: NOT_YET_RECRUITING
Conditions: Anorexia Nervosa Restricting Type|Binge-Eating Disorder
Interventions: DRUG: Midomafetamine|BEHAVIORAL: Non-directive therapy|BEHAVIORAL: Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Children With Kidney Transplants by Injection of CD4+CD25+FoxP3+ T Cells to Prevent Organ Rejection
Status: UNKNOWN
Conditions: End-Stage Renal Disease|Kidney Failure
Interventions: BIOLOGICAL: CD4+CD25+CD127lowFoxP3+ T regulatory cells injection|DRUG: Alemtuzumab|DRUG: Mycophenolate mofetil|DRUG: Sirolimus|DRUG: Tacrolimus|DRUG: Cyclosporine|DRUG: Everolimus|PROCEDURE: Kidney transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Walking Aids on the Occurrence of Carpal Tunnel Syndrome in Rehabilitation
Status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Interventions: DIAGNOSTIC_TEST: nerve conduction study|DIAGNOSTIC_TEST: ultrasonography wrists|DIAGNOSTIC_TEST: Boston carpal tunnel questionnaire|DIAGNOSTIC_TEST: clinical provocative tests for carpal tunnel syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Autism Oxytocin Brain Project
Status: COMPLETED
Conditions: Autism|Autism Spectrum Disorder
Interventions: DRUG: 8 International Units (IU) of Oxytocin|DRUG: 24IU of Oxytocin|DRUG: 48IU of Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia
Status: COMPLETED
Conditions: Familial Dysautonomia
Interventions: DRUG: Carbidopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating Tolerability of Grazax Treatment in Combination With Antihistamine
Status: COMPLETED
Conditions: Allergic Rhinoconjunctivitis
Interventions: DRUG: Grazax + Aerius|DRUG: Grazax + placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Usability, Acceptability, and Perceived Value of the Cornerstones4Care Powered by Glooko App
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Cornerstones4Care Powered by Glooko App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Open-Label Extension of Study R727-CL-1003 (NCT01266876) to Evaluate the Long-Term Safety and Efficacy of Alirocumab (REGN727) in Participants With Heterozygous Familial Hypercholesterolemia (HeFH)
Status: COMPLETED
Conditions: Hypercholesterolemia|Heterozygous Familial Hypercholesterolemia
Interventions: DRUG: Alirocumab|DRUG: Placebo Matched to Alirocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Immunogenicity of INO-4500 in Healthy Volunteers
Status: COMPLETED
Conditions: Lassa Fever
Interventions: DRUG: INO-4500|DRUG: Placebo|DEVICE: CELLECTRA® 2000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Increased CF-LVAD Pump Speed During Sustained Submaximal Exercise
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: CF-LVAD pump speed baseline.|OTHER: CF-LVAD pump speed increased.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Safety and Efficacy of CCRT With Paclitaxel/Carboplatin as Adjuvant Therapy to Post-operative Cervical Cancer Patients
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: paclitaxel, carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Results of Allogeneic Hematopoietic Stem Cells Versus Ponatinib in CML Patients Carrying a Mutation T315I
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Ponatinib (Iclusig®)|PROCEDURE: allogeneic stem cell transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Finding a Safe and Effective Dose of Linagliptin in Pediatric Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: placebo|DRUG: BI1356 low dose|DRUG: BI1356 high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder
Status: UNKNOWN
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Pictures|BEHAVIORAL: Startle eliciting noise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Communication Strategies for Mechanically Ventilated Patients in Intensive Care Units
Status: COMPLETED
Conditions: Mechanical Ventilation Complication|Communication, Nonverbal
Interventions: DEVICE: Comparison between communication board and eye tracking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Integration of the PD-L1 Inhibitor Atezolizumab and WT1/DC Vaccination Into Platinum/Pemetrexed-based First-line Treatment for Epithelioid Malignant Pleural Mesothelioma
Status: RECRUITING
Conditions: Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: Dendritic cell vaccination|DRUG: Atezolizumab|DRUG: Platinum/pemetrexed based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Clinical Study to Evaluate SYN023's Efficacy and Safety
Status: COMPLETED
Conditions: Rabies|Communicable Disease|Virus Diseases|Rhabdoviridae Infections|Mononegavirales Infections|RNA Virus Infections
Interventions: BIOLOGICAL: SYN023|BIOLOGICAL: Human Rabies Immune Globulin (HRIG)|BIOLOGICAL: Rabies Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficacy of ROPIVACAINE in Children and Young Adults With Hereditary Epidermolysis Bullosa
Status: COMPLETED
Conditions: Epidermolysis Bullosa
Interventions: DRUG: Ropivacaine|BIOLOGICAL: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenecity of LBVE(Multivalent Pneumococcal Conjugate Vaccine) in Healthy Infants
Status: COMPLETED
Conditions: Pneumococcal Infection
Interventions: BIOLOGICAL: LBVE|BIOLOGICAL: Prevnar13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effect of the Different Methods of Kinesiology Taping on the Muscle Contraction Performance of Fatigued Biceps Brachii
Status: COMPLETED
Conditions: Muscle Fatigue
Interventions: OTHER: Kinesiology taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Piezowave for Treatment on Lateral and Medial Elbow Tendinopathies
Status: WITHDRAWN
Conditions: Elbow Tendinopathy|Golfer's Elbow|Medial Epicondylitis|Lateral Epicondylitis|Tennis Elbow
Interventions: DEVICE: Piezowave 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh
Status: RECRUITING
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Novel Live Attenuated Type 1 Oral Poliomyelitis Vaccine (nOPV1)|BIOLOGICAL: Sabin Monovalent Oral Poliomyelitis Vaccine Type 1 (mOPV1)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety And Efficacy Of Empagliflozin In Pakistani Muslim Population With Type Ii Diabetes Mellitus
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: Empagliflozin|DRUG: Usual care group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use Opioids
Status: COMPLETED
Conditions: Opiate Dependence
Interventions: DRUG: Medisorb naltrexone 75 mg|DRUG: Medisorb naltrexone 150 mg|DRUG: Medisorb naltrexone 300 mg|DRUG: Hydromorphone (10 mg/mL)|DRUG: Naloxone Challenge and Oral Naltrexone Tolerability Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AllyQuest Adherence App Intervention for HIV-positive Men Who Have Sex With Men and Transgender Women: Pilot Trial
Status: COMPLETED
Conditions: Hiv|HIV/AIDS|Medication Adherence|Sexual Behavior|Sexually Transmitted Infections (Not HIV or Hepatitis)
Interventions: BEHAVIORAL: AllyQuest HIV Medication Adherence app-delivered intervention|BEHAVIORAL: AllyQuest HIV Medication Adherence app-delivered intervention + NSC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Short SPIRIT Checklist for Peer Reviewers to Improve the Reporting Quality in Published Articles (SPIRIT-PR)
Status: COMPLETED
Conditions: Adequate Reporting in Published Study Protocols of Randomized Controlled Trials
Interventions: OTHER: SPIRIT checklist plus usual practice|OTHER: Usual practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Green Coffee Extract Supplementation and Oxidative Stress, Systemic and Vascular Inflammation
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: green coffee extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Wearable Exercise Trackers in Cancer Rehabilitation
Status: COMPLETED
Conditions: Benign Neoplasms|In Situ Neoplasms|Malignant Neoplasms of Independent (Primary) Multiple Sites
Interventions: BEHAVIORAL: Questionnaires|DEVICE: Wearable Exercise Tracker Watch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery
Status: COMPLETED
Conditions: Lower Limb Surgery
Interventions: DRUG: Levobupivacaine|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Irinotecan and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases From Solid Tumors
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Cognitive/Functional Effects|Long-term Effects Secondary to Cancer Therapy in Adults|Long-term Effects Secondary to Cancer Therapy in Children|Poor Performance Status|Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: irinotecan hydrochloride|PROCEDURE: cognitive assessment|PROCEDURE: management of therapy complications|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Rapid Evaluation of Pandemic H1N1 Influenza Vaccine in Adults Receiving Seasonal Influenza Vaccine
Status: COMPLETED
Conditions: Influenza|H1N1 2009 Influenza
Interventions: BIOLOGICAL: Arepanrix, Vaxigrip 2009/2010|BIOLOGICAL: Arepanrix, Vaxigrip 2009/2010
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tightrope Fixation of Acromioclavicular Joint Dislocation - a Prospective Series
Status: COMPLETED
Conditions: Acromioclavicular Joint Dislocation
Interventions: PROCEDURE: Tightrope fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Whey Protein And Casein Supplementation: Effect On Protein Metabolism After Resistance Exercise
Status: COMPLETED
Conditions: Sports Nutrition|Protein Supplementation
Interventions: DIETARY_SUPPLEMENT: Blend Protein Supplementation|DIETARY_SUPPLEMENT: Placebo Supplementation|OTHER: Resistance Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Core Stabilization Exercises With and Without Dry Cupping in Patients With Sacroiliac Joint Dysfunction
Status: UNKNOWN
Conditions: Sacroiliac Joint Dysfunction
Interventions: OTHER: Dry cupping with core stabilization exercises|OTHER: Core stabilization exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Pain|Post Stroke Pain|Phantom Limb Pain|Spinal Cord Injuries
Interventions: DEVICE: Open-Loop DBS|DEVICE: Sham Stimulation|DEVICE: Closed-Loop DBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Re-irradiation Therapy of Locally Recurrent Rectal Cancer With Carbon Ion
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer|Recurrent
Interventions: RADIATION: Carbon ion radiation therapy DT: 74Gy/20 fractions
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of EGFR TKI Resistance Mechanism Using Plasma DNA Analysis
Status: UNKNOWN
Conditions: EGFR Mutation Positive Non-small Cell Lung Cancer
Interventions: DRUG: EGFR TKIs (gefitinib, erlotinib, afatinib, et al)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase I Trial to Investigate Cafusertib Hydrochloride Monotherapy in Chinese Patients With Advanced Solid Tumours
Status: UNKNOWN
Conditions: Neoplasms
Interventions: DRUG: Cafusertib Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastrointestinal Stromal Tumors|Sdh|GIST|Cancer
Interventions: DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Prebiotics on GLP-1 in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Type 2
Interventions: DIETARY_SUPPLEMENT: Prebiotic fibers: oligofructose and inulin|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High Dose of Dual Therapy Plus Bismuth for Helicobacter Pylori Treatment
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Esomeprazole|DRUG: Amoxicillin|DRUG: Bismuth Potassium Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection
Status: RECRUITING
Conditions: Recurrent Clostridioides Difficile Infection|Colonic Surgery
Interventions: DRUG: IMT|OTHER: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety for Telitacicept in the Remission Maintenance Treatment of ANCA-associated Vasculitis (TTCAZAREM)
Status: RECRUITING
Conditions: ANCA-associated Vasculitis|Maintenance Therapy
Interventions: DRUG: Azathioprine|DRUG: Telitacicept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of Laser Assisted Drug Delivery of NanoDOX®
Status: RECRUITING
Conditions: Wounds and Injury
Interventions: DRUG: NanoDOX® Hydrogel|DEVICE: CO2 Ablative Fractional Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors
Status: RECRUITING
Conditions: Non Hodgkin Lymphoma (NHL)|Peripheral T-cell Lymphoma (PTCL)|Cutaneous T-Cell Lymphoma (CTCL)|Large Granular Lymphocytic Leukemia (LGL-L)|T-cell Prolymphocytic Leukemia (T-PLL)|Solid Tumors
Interventions: DRUG: KT-333
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DBPR108 Tablets in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DBPR108 tablet(50mg), Placebo matching DBPR108 tablet(100mg)|DRUG: DBPR108 tablet(100mg), Placebo matching DBPR108 tablet(50mg), Placebo matching DBPR108 tablet(100mg)|DRUG: DBPR108 tablet(100mg), Placebo matching DBPR108 tablet(50mg)|DRUG: Placebo matching DBPR108 tablet(100mg), Placebo matching DBPR108 tablet(50mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The REPOSE (Relative Effectiveness of Pumps Over MDI and Structured Education) Trial
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: CSII (Insulin Pump) plus DAFNE|OTHER: MDI (levemir® & quick acting insulin) plus DAFNE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Doses of Sirolimus for the Maintenance Treatment of Kaposiform Hemangioendothelioma
Status: RECRUITING
Conditions: Hemangioendothelioma
Interventions: DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NEPHRODIAB2 Prospective Randomized Controlled Open-Labelled Trial Comparing Effect of Two Haemoglobin Levels
Status: UNKNOWN
Conditions: Chronic Kidney Disease
Interventions: DRUG: GROUP A: if necessary, martial treatment and / or erythropoietin treatment to achieve the goal of haemoglobin level from 110 to 129 g/L.|DRUG: GROUP B: martial treatment and / or erythropoietin treatment to achieve the goal of haemoglobin level from 130 to 149 g/L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Nivolumab in Treating Patients With Metastatic Adrenocortical Cancer
Status: TERMINATED
Conditions: Metastatic Carcinoma in the Adrenal Cortex|Recurrent Adrenal Cortex Carcinoma|Stage III Adrenal Cortex Carcinoma|Stage IV Adrenal Cortex Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel
Status: TERMINATED
Conditions: Urologic Diseases|Hypospadias|Undescended Testes|Chordee|Hydrocele|Orchiectomy
Interventions: DRUG: Exparel 133 miligrams per 10 milliliter injection|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparing Brief Alcohol Interventions For HIV-HCV Co-infected Persons
Status: COMPLETED
Conditions: HIV|Hepatitis C
Interventions: BEHAVIORAL: Motivational Interviewing|BEHAVIORAL: Brief Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Postoperative Inflammation in Cataract Surgery
Status: COMPLETED
Conditions: Inflammation Following Cataract Surgery
Interventions: DRUG: antibiotic/steroid combination|DRUG: moxifloxacin / dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy and Safety of Insulin Glargine Injected by Needle-free Jet Syringe
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: The needle-free jet injector
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Chronic CMV Infection on Influenza Vaccine Responses
Status: COMPLETED
Conditions: Cytomegalovirus Infections|Influenza
Interventions: BIOLOGICAL: Fluzone® 2012-2013 Formula NDC No 498281-012-50
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pulsed Low Dose Rate Radiation With Concurrent Chemotherapy for Non-Small Cell Lung Cancer and Esophageal Cancer
Status: RECRUITING
Conditions: Lung Cancer|Esophageal Cancer
Interventions: RADIATION: Pulsed Low Dose Radiation|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FLT3 Ligand, CD40 Agonist Antibody, and Stereotactic Radiotherapy
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Lung Cancer
Interventions: DRUG: FLT3 Ligand (CDX-301)|BIOLOGICAL: anti-CD40 antibody (CDX-1140)|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Movement Characterization in Spastic/Dystonic Cerebral Palsy Using Haptic Feedback in Virtual Reality
Status: UNKNOWN
Conditions: Cerebral Palsy, Mixed|Cerebral Palsy, Spastic
Interventions: BEHAVIORAL: Force efforts with haptic feedback in virtual reality.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of Endothelium-dependent Vasodilation in Human Gingiva
Status: ACTIVE_NOT_RECRUITING
Conditions: Vasodilation|Oral Soft Tissue Conditions
Interventions: DRUG: Acetylcholine Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
Status: RECRUITING
Conditions: Heart Failure|Acute Decompensated Heart Failure
Interventions: DEVICE: Impella BTR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Efficacy Study of Community-Based Treatment of Serious Bacterial Infections in Young Infants
Status: UNKNOWN
Conditions: Bacterial Infection|Sepsis|Infant, Newborn
Interventions: DRUG: ceftriaxone, procaine penicillin and gentamicin, oral cotrimoxazole and gentamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: iTBS+D-Cycloserine for Youth Suicide
Status: RECRUITING
Conditions: Suicidal Ideation|Suicide, Attempted|Depression, Anxiety
Interventions: DRUG: D-Cycloserine|DEVICE: intermittent Theta-Burst-repetitive Transcranial Magnetic Stimulation|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Midline Versus Paramedian Approaches in Treating Degenerative Lumbar Spondylolisthesis
Status: RECRUITING
Conditions: Spondylolisthesis, Lumbar Region
Interventions: OTHER: Surgical approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Aztreonam for Inhalation Solution (AZLI) for the Treatment of Exacerbations of Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis|Infection|Pseudomonas
Interventions: DRUG: Aztreonam|DRUG: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Clinical Efficacy of Chinese Medicine Treatment of Sequelae of Apoplexy
Status: UNKNOWN
Conditions: Stroke
Interventions: COMBINATION_PRODUCT: Chinese medicine treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study of Modified Vaccinia Virus to Treat Sorafenib-naïve Advanced Liver Cancer
Status: COMPLETED
Conditions: Hepatocellular Carinoma
Interventions: BIOLOGICAL: JX-594 recombinant vaccina GM-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cocoa Intake and Muscle Pain Sensation
Status: COMPLETED
Conditions: Muscle Pain
Interventions: OTHER: before - hypertonic saline 5%|OTHER: after - hypertonic saline 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study
Status: RECRUITING
Conditions: Inflammation|Frailty
Interventions: DRUG: Clazakizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prostate Adenocarcinoma TransCutaneous Hormones
Status: UNKNOWN
Conditions: Anemia|Cardiovascular Complications|Hot Flashes|Osteoporosis|Prostate Cancer
Interventions: DRUG: Goserelin|DRUG: Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Sacrocolpopexy Versus POPS in the Management of Pelvic Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: Laparoscopic procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Lung Surgery Under ERAS With Completely Tubeless Protocol Compared With That With Partially Tubeless Protocol
Status: RECRUITING
Conditions: Lung Diseases|ERAS|Surgery
Interventions: PROCEDURE: Minimally Invasive Lung Surgery Under ERAS With Completely Tubeless Protocol|PROCEDURE: Minimally Invasive Lung Surgery Under ERAS With partially Tubeless Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of Multiple Doses of Rifampicin on the Multiple-dose Pharmacokinetics of Linagliptin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rifampicin|DRUG: Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations
Status: COMPLETED
Conditions: Advanced Malignant Solid Neoplasm
Interventions: DRUG: Adavosertib|DRUG: Carboplatin|DRUG: Everolimus|DRUG: Temozolomide|DRUG: Trametinib|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous (IV) Paracetamol for Treatment of Acute Pain
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPACE (SPS ADVANCED CAGE): SPS Spacer for Intervertebral Fusion, Longitudinal, Prospective Clinical Study
Status: NOT_YET_RECRUITING
Conditions: Treatment of Degenerative Diseases of the Spine
Interventions: DEVICE: Intersomatic arthrodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 2 Period Cross-over Pharmacokinetic Study of SB204 in Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: SB204|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Saroglitazar Magnesium 4 mg for NASH in People Living With HIV in the US
Status: RECRUITING
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Saroglitazar Magnesium 4 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-operative Sensitivity in Resin Composites
Status: COMPLETED
Conditions: Caries,Dental|Sensitivity, Tooth
Interventions: PROCEDURE: Group A(Nano-fortified Adhesive)|PROCEDURE: Group B(Adhesive without nanoparticles)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis for NSAID VS Corticosteroid Shoulder Injection in Diabetic Patients
Status: WITHDRAWN
Conditions: Rotator Cuff Tear|Rotator Cuff Injury|Rotator Cuff Tendinitis|Diabetes Mellitus
Interventions: DRUG: Ketorolac|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function
Status: UNKNOWN
Conditions: Nitroprusside|Thyroid Hormones
Interventions: DRUG: sodium nitroprusside|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Body Composition Manipulation in CoLorectal cancEr (BiCyCLE): Neuromuscular Electrical Stimulation (NMES)
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer|Colorectal Cancer|Colon Cancer|Colo-rectal Cancer|Sarcopenia|Sarcopenic Obesity|Advanced Cancer|Recurrent Rectal Cancer
Interventions: DEVICE: Microstim 2v2 Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Amonafide in Combination With Cytarabine in Secondary AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Amonafide L-Malate|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PJ009 in Patients With Short Bowel Syndrome Requiring Parenteral Nutrition
Status: RECRUITING
Conditions: Short Bowel Syndrome
Interventions: DRUG: PJ009|DRUG: PJ009 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Clinical Trial of Colostomy-replacement Combined With Bio-mesh Placement in the Prevention of SSIH
Status: RECRUITING
Conditions: Stoma Site Incisional Hernia
Interventions: PROCEDURE: Stoma reversal with bio-mesh placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Coaching Intervention for Caregivers of Persons With Stroke
Status: UNKNOWN
Conditions: Caregiver Stress Syndrome|Caregiver Burnout|Stroke, Acute
Interventions: BEHAVIORAL: Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel for the Treatment of Upper-Extremity Arteriovenous Access Fistula Stenosis
Status: TERMINATED
Conditions: Fistula Stenosis
Interventions: DRUG: Paclitaxel|PROCEDURE: Standard Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: In-Home Care for Patients With PSP and Related Disorders
Status: COMPLETED
Conditions: Progressive Supranuclear Palsy|Dementia With Lewy Bodies|Multiple System Atrophy|Corticobasal Syndrome|Atypical Parkinson Disease
Interventions: BEHAVIORAL: Home Visit Program|BEHAVIORAL: Usual Care/Online Survey
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1 Study of AMG 208 in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Cancer|Oncology|Tumors|Advanced Malignancy|Advanced Solid Tumors|Oncology Patients
Interventions: DRUG: AMG 208
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Autologous Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Stage IV Melanoma
Status: COMPLETED
Conditions: Recurrent Melanoma|Stage IV Melanoma
Interventions: DRUG: cyclophosphamide|BIOLOGICAL: therapeutic autologous lymphocytes|BIOLOGICAL: aldesleukin|OTHER: immunohistochemistry staining method|PROCEDURE: biopsy|OTHER: laboratory biomarker analysis|OTHER: immunologic technique|GENETIC: polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of PSTon Mental Health Outcomes in Caregivers of Post-9/11 Combat Veterans With a Traumatic Brain Injury
Status: COMPLETED
Conditions: Military Family|Brain Injuries, Traumatic
Interventions: BEHAVIORAL: Problem-Solving Thearpy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill
Status: UNKNOWN
Conditions: Critically Ill|Acute Kidney Injury|Septic Shock
Interventions: DEVICE: AN 69 ST hemofilter|DEVICE: AN 69 hemofilter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Linagliptin on Mitochondrial and Endothelial Function
Status: COMPLETED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: Linagliptin|DRUG: Placebo|OTHER: Microcirculation testing|OTHER: Macrocirculation testing|OTHER: MRI Scans
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study (EFS) Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System
Status: RECRUITING
Conditions: Tricuspid Regurgitation
Interventions: DEVICE: Laplace TTVR System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Phase IIIb Study to Compare Entecavir Plus Tenofovir vs. Adefovir Added to Continuing Lamivudine Therapy in Adult Patients With Lamivudine-Resistant Hepatitis B Infection
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Entecavir + Tenofovir|DRUG: Adefovir + continuing Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of 18F-AV-133 Positron Emission Tomography (PET) Imaging to Differentiate Subjects With Parkinson's Disease (PD) From Other Movement Disorders
Status: COMPLETED
Conditions: Parkinson's Disease|Primary Parkinsonism|Lewy Body Parkinson's Disease
Interventions: DRUG: 18F-AV-133
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: SER100 in Isolated Systolic Hypertension
Status: COMPLETED
Conditions: Isolated Systolic Hypertension
Interventions: DRUG: SER100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Purified Vero Rabies Vaccine Compared With a Reference Rabies Vaccine as Simulated Rabies Post-Exposure Prophylaxis in Adult and Pediatric Population in Thaïland
Status: COMPLETED
Conditions: Rabies (Healthy Volunteers)
Interventions: BIOLOGICAL: Purified vero rabies vaccine - serum free VRVg-2|BIOLOGICAL: Purified inactivated rabies vaccine|BIOLOGICAL: Equine rabies immunoglobulins (ERIG) (only Group 3 and Group 4)|BIOLOGICAL: Human rabies immunoglobulins (HRIG) (only Group 5 and Group 6)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION