pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X)
Status: TERMINATED
Conditions: Chronic Uveitis
Interventions: BIOLOGICAL: Gevokizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DS-8201a in Pre-treated HER2 Breast Cancer That Cannot be Surgically Removed or Has Spread [DESTINY-Breast02]
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab deruxtecan|DRUG: Capecitabine|DRUG: Lapatinib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study on Kangfu Anti-inflammatory Suppository of Gynaecology Combined With Antibiotics for Pelvic Inflammatory Diseases (Evidence of Dampness and Heat Accumulation)
Status: UNKNOWN
Conditions: Pelvic Inflammatory Diseases
Interventions: DRUG: Kangfu Anti-inflammatory Suppository
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia (AML)|Cancer
Interventions: DRUG: Venetoclax|DRUG: Azacitidine|OTHER: Best Supportive Care (BSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Mesenchymal Stem Cells Transplantation for Primary Sjögren's Syndrome (pSS)
Status: UNKNOWN
Conditions: Sjogren's Syndrome|Mesenchymal Stem Cells
Interventions: BIOLOGICAL: Allogeneic Mesenchymal Stem Cells (AlloMSC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SIROOP Registry - A Prospective Registry Study to Evaluate the Outcomes of Coronary Artery Disease Patients Treated With SIROlimus Or Paclitaxel Eluting Balloon Catheters
Status: RECRUITING
Conditions: Coronary Disease|Coronary Artery Disease|Coronary Restenosis|Coronary Arteriosclerosis|Coronary Artery Calcification|Stable Chronic Angina|Angina Pectoris|Angina, Stable|Angina, Unstable|Stent Thrombosis
Interventions: DEVICE: Sirolimus Eluting Balloon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study About Treatment of Newly Diagnosed Non Cutaneous Peripheral T Cell Lymphoma
Status: COMPLETED
Conditions: Peripheral T Cell Lymphoma
Interventions: DRUG: CHOP21|DRUG: VIP/ABVD|RADIATION: Radiotherapy consolidation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Aggregation and Adenosine Levels Among Patients Taking Ticagrelor or Prasugrel
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Prasugrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Potential Role of Gastric Lavage by Paraffin Oil in Acute Aluminum Phosphide Poisoning
Status: RECRUITING
Conditions: Toxicity, Drug
Interventions: DEVICE: Paraffin oil gastric lavage|DEVICE: Gastric lavage with saline and sodium bicarbonate 8.4%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ezetimibe/Simvastatin 10/20 mg and MK0524A (1-2 g/Day) in Mixed Hyperlipidemia and Two or More Risk Factors
Status: WITHDRAWN
Conditions: Cardiovascular Diseases|Hyperlipidemia
Interventions: DRUG: ezetimibe/simvastatin 10/20 mg + placebo|DRUG: ezetimibe/simvastatin 10/20 mg + MK0524A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rapamycin Plus Bevacizumab in Advanced Cancers
Status: COMPLETED
Conditions: Advanced Cancer|Metastatic Cancer
Interventions: DRUG: Rapamycin (liquid)|DRUG: Bevacizumab|DRUG: Rapamycin (Tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensive Education Versus Usual Education of Patients for Improving Guideline Directed Medical Therapy (GDMT) Prescription in Heart Failure With Reduced Ejection Fraction
Status: RECRUITING
Conditions: Heart Failure|Patient Acceptance of Health Care
Interventions: BEHAVIORAL: Patient education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Eurékoi Serious Game on Family Caregivers of Patients With a Major Neurocognitive Disorder
Status: COMPLETED
Conditions: Family Caregiver of Patient With Alzheimer Disease
Interventions: BEHAVIORAL: Serious game Eurekoi intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Evaluate the Safety and Efficacy of Alefacept (Amevive) in Subjects With Moderate to Severe Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Alefacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Green Tea Extract on Lipids in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Dyslipidemias|Arterial Stiffness
Interventions: DIETARY_SUPPLEMENT: Green tea extract|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Oral Budesonide and Rectal Hydrocortisone for the Treatment of Active Ulcerative Colitis
Status: TERMINATED
Conditions: Inflammatory Bowel Disease|Ulcerative Colitis
Interventions: DRUG: Combination Oral Budesonide and Rectal Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Capecitabine In Combination With Cemiplimab In Patient With Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hormone Receptor-positive Breast Cancer
Interventions: DRUG: Cemiplimab|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erb:Yag Laser Versus Pelvic Floor Training for the Treatment of Women With Mild to Moderate Stress Urinary Incontinence
Status: UNKNOWN
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Erbium Yag Laser|BEHAVIORAL: Pelvic Floor Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circulating Tumor Cells in Patients With Locally Advanced Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Rectal Adenocarcinoma|Metastatic Rectal Adenocarcinoma|Rectosigmoid Adenocarcinoma|Recurrent Rectal Adenocarcinoma|Recurrent Rectosigmoid Carcinoma|Stage III Rectal Cancer AJCC v8|Stage IIIA Rectal Cancer AJCC v8|Stage IIIB Rectal Cancer AJCC v8|Stage IIIC Rectal Cancer AJCC v8|Stage IV Rectal Cancer AJCC v8|Stage IVA Rectal Cancer AJCC v8|Stage IVB Rectal Cancer AJCC v8|Stage IVC Rectal Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of the Mobile Application for Prediction and Prevention of Mood Episode Recurrence Based on Machine Learning
Status: RECRUITING
Conditions: Major Depressive Disorder|Bipolar 1 Disorder|Bipolar II Disorder
Interventions: OTHER: Circadian Rhythms for Mood (CRM) application - Active|OTHER: Circadian Rhythms for Mood (CRM) application - Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: StrokeNet Thrombectomy Endovascular Platform
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke
Interventions: DEVICE: Endovascular thrombectomy with any FDA-approved category POL or NRY device|OTHER: Medical Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Post-market Registry of the MARIS-stent (Invatec) Implanted in the Superficial Femoral Artery
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: MARIS-stent (Invatec)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Peritoneal Lavage or Resection for Generalised Peritonitis for Perforated Diverticulitis
Status: UNKNOWN
Conditions: Perforated Diverticulitis
Interventions: PROCEDURE: Laparoscopic lavage and drainage|PROCEDURE: Sigmoidectomy with primary anastomosis|PROCEDURE: Sigmoidectomy with end-colostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diaphragmatic Myofascial Release in Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: OTHER: Diaphragmatic myofascial release|OTHER: Sham myofascial release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Double-lumen Endobronchial Intubation
Status: UNKNOWN
Conditions: Intubation, Intratracheal
Interventions: DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Low Dose vs Standard Ticagrelor on Platelet Function After Intervention for Acute Coronary Syndrome in Senior Patients
Status: RECRUITING
Conditions: Senior Acute Coronary Syndrome Patients After PCI
Interventions: DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Study of Carebot AI CXR Performance in Preclinical Practice
Status: COMPLETED
Conditions: Artificial Intelligence|Lung Diseases|Pneumothorax|Pleural Effusion|Cardiomegaly|Lung Cancer|Pulmonary Edema|Consolidation|Pneumonia|Atelectasis|Hilar Calcification|Fracture Rib
Interventions: DEVICE: Carebot AI CXR
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Determinants of the Level of Anti-SARS-CoV-2 IgG ANTibodiEs After Vaccination Study
Status: UNKNOWN
Conditions: SARS-CoV2 Infection|SARS-CoV2 Antibodies
Interventions: DIAGNOSTIC_TEST: assessment of the anti-SARS-CoV-2 IgG antibody titer in 3-dose schedule|DIAGNOSTIC_TEST: assessment of the anti-SARS-CoV-2 IgG antibody titer in 2-dose schedule
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial
Status: RECRUITING
Conditions: Neuromuscular Blocks
Interventions: DRUG: 2 mg/kg sugammadex|DRUG: 0.07 mg/kg neostigmine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dyadic Approach for Promoting Physical Activity Among People With MS and Their Support Partners
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Physical Activity Together for PwMS and their CGs (PAT-MS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: US-guided SAPB for Rib Fractures in the ED
Status: UNKNOWN
Conditions: Rib Fractures|Rib Fracture Multiple
Interventions: DRUG: Bupivacaine|DRUG: Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Efficacy of Sacral Espb and Caudal Block for Pain Management After Urogenital Surgeries in Children
Status: COMPLETED
Conditions: Urogenital Diseases|Nerve Block|Pain, Postoperative
Interventions: PROCEDURE: Ultrasound-guided sacral erector spinae plane block|PROCEDURE: Ultrasound-guided caudal block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Laryngoscopes: Single-use Device Laryngobloc ® (SU) Versus Reusable Handle With Disposable Metal Blade (R)
Status: UNKNOWN
Conditions: Contamination of the Handles|Quality of the Laryngoscopy
Interventions: DEVICE: The two groups SU and R are defined by the device with which intubation is performed after a first laryngoscopy done with the other device.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Quadratus Lumborum Block With Compound Lidocaine and Esketamine on Pain After Colorectal Surgery
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Normal saline|DRUG: Ropivacaine|DRUG: Compound lidocaine|DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Tebipenem pivoxil hydrobromide (TBPM-PI-HBr)|DRUG: 20 mL aluminum hydroxide/magnesium hydroxide/simethicone (400 mg aluminum hydroxide/400 mg magnesium hydroxide/40 mg simethicone per 5 mL)|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Brexpiprazole as Adjunctive Treatment of Irritability in Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Therapy
Status: COMPLETED
Conditions: Major Depressive Disorder|Irritability
Interventions: DRUG: Brexpiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction of Labor With Single and Double Balloon Catheters, a Randomized Controlled Study
Status: COMPLETED
Conditions: Induction of Birth
Interventions: DEVICE: Foley Catheter|DEVICE: Double Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Is Any Additional Information Gained Regarding Margins Using 3D Tomosynthesis Vs 2D Conventional Digital Imaging When Imaging Operative Breast Specimens?
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: 3 dimensional tomosynthesis imaging|RADIATION: 2 dimensional digital imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: ADX10059|DRUG: ADX10059|DRUG: ADX10059|DRUG: ADX10059 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lymfit to Improve the Fitness and Quality of Life in Lymphoma Survivors
Status: RECRUITING
Conditions: Lymphoma|Cancer Survivors
Interventions: BEHAVIORAL: Lymfit exercise intervention|BEHAVIORAL: Waitlist control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatric Patients
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: pyronaridine artesunate|DRUG: arthemeter lumefantrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structure and Function of the Gastro-esophageal Junction
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Baclofen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Immunogenicity and Safety of Combined Immunization of sIPV, DTaP and MMR
Status: UNKNOWN
Conditions: Vaccine
Interventions: BIOLOGICAL: sIPV+DTaP+MMR|BIOLOGICAL: sIPV|BIOLOGICAL: DTaP|BIOLOGICAL: MMR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BAY88-8223, Alpharadin, Breast Cancer Patients With Bone Dominant Disease
Status: COMPLETED
Conditions: Breast Cancer|Bone Metastases
Interventions: DRUG: Radium-223 chloride (BAY88-8223)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Gluten Sensitivity in Irritable Bowel Syndrome: The First Study in Paediatrics.
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome|Gluten Sensitivity
Interventions: DIETARY_SUPPLEMENT: gluten|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Ovine Graft (Omniflow II) Versus PTFE in Below Knee Arterial Reconstruction
Status: WITHDRAWN
Conditions: Peripheral Arterial Occlusive Disease
Interventions: DEVICE: Below Knee Arterial Reconstruction|DEVICE: Below Knee Arterial Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Latent Pulmonary Arterial Hypertension in Congenital Shunt Lesions
Status: COMPLETED
Conditions: Atrial Septal Defects|Ventricular Septal Defects
Interventions: OTHER: No intervention was applied, because it is an observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Conventional vs. Endoscopic Lumbar Discectomy
Status: COMPLETED
Conditions: Lumbar Disc Herniation
Interventions: PROCEDURE: Conventional open lumbar discectomy|PROCEDURE: Percutaneous Endoscopic Translaminar lumbar discectomy.|DEVICE: Easy Go system Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Short-term Choir Participation on Auditory Perception in Hearing-aided Older Adults.
Status: TERMINATED
Conditions: Hearing Loss|Auditory Perception|Music Therapy|Aging
Interventions: BEHAVIORAL: Choir Singing|BEHAVIORAL: Music Appreciation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer
Status: RECRUITING
Conditions: Leptomeningeal Metastasis|Immune Checkpoint Inhibitor|Endostatin
Interventions: DRUG: Camrelizumab or envafolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Plasmatic NGAL as a Predictive Marker of Renal Injury in Children With Urinary Infection. (Perf-NGAL-IU)
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DIAGNOSTIC_TEST: plasmatic NGAl and MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Perfusion Pressure Cerebral Infarction Trial (PPCI)
Status: COMPLETED
Conditions: Embolic Stroke|Postoperative Cognitive Dysfunction
Interventions: PROCEDURE: Increased bloodpressure during CPB.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Test if TEV-48574 is Effective in Relieving Asthma
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: TEV-48574|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina Faso
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: DHA-PQ|DRUG: SP-AQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TEAM-Trial: Targeting Epigenetic Therapy Resistance in AML With Bortezomib
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Bortezomib|DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regenerative Endodontic Treatment of Traumatised Teeth
Status: COMPLETED
Conditions: Tooth Injuries|Endodontically Treated Teeth
Interventions: PROCEDURE: RET using Ciprofloxacin 100mg, and Metronidazole 100mg.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Major Depression With EEG and Near Infrared Spectroscopy (NIRS) Monitoring
Status: TERMINATED
Conditions: Depression
Interventions: PROCEDURE: Transcranial Magnetic Stimulation (TMS)|DEVICE: near infrared spectroscopy (NIRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Home-based Health Management of Chronic Obstructive Lung Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease|Emphysema|Pulmonary Rehabilitation
Interventions: BEHAVIORAL: Home-base Pulmonary Rehab with Health Coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glucophage® Extended Release (XR) 750 Milligram (mg) Indonesia Bioequivalence (BE) Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glucophage XR (Test drug)|DRUG: Glucophage XR (Comparator drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
Status: RECRUITING
Conditions: Coronary Artery Stenosis
Interventions: PROCEDURE: State-of-the-Art Percutaneous Coronary Intervention|PROCEDURE: standard CABG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria
Status: COMPLETED
Conditions: Primary Hyperoxaluria
Interventions: BIOLOGICAL: Oxabact OC5 - Oxalobacter formigenes HC-1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RCT Social Cognition Training and Therapeutic Alliance Focused Therapy for Persons With Severe Mental Illness
Status: COMPLETED
Conditions: Mental Disorders
Interventions: BEHAVIORAL: SCIT|BEHAVIORAL: TAFT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Incidence of Glistenings in the 2017 Intraocular Lenses Made by Alcon and Abbott Medical Optics
Status: TERMINATED
Conditions: Cataracts|Visual Acuity Reduced Transiently|Loss of Visual Contrast Sensitivity|Functional Visual Loss
Interventions: DEVICE: Alcon 1 piece SA60AT lens|DEVICE: AMO 1-piece AABOO lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Squalamine Lactate Plus Carboplatin in Treating Patients With Recurrent or Refractory Stage III or Stage IV Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: carboplatin|DRUG: squalamine lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Neurocysticercosis: Combined Treatment With Praziquantel (PZQ) and Albendazole (ABZ)
Status: COMPLETED
Conditions: Neurocysticercosis|Epilepsy
Interventions: DRUG: Praziquantel|DRUG: Albendazole|DRUG: ABZ Placebo|DRUG: PZQ Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Merit WRAPSODY™ Endovascular Stent Graft for Treatment of Iliac Artery Occlusive Disease
Status: WITHDRAWN
Conditions: Stenosis of Artery|Peripheral Arterial Disease|Iliac Artery Disease|Iliac Artery Occlusion
Interventions: DEVICE: Placement of WRAPSODY stent graft
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulse Pressure and Post-epidural Fetal Heart Rate Changes
Status: COMPLETED
Conditions: Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Interventions: DRUG: Lactated Ringer's
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dapagliflozin After Transcatheter Aortic Valve Implantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Stenosis|Transcatether Aortic Valve Implantation
Interventions: DRUG: Dapagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of IRNEA (Irinotecan, Etoposide, Cytarabine) for Refractory or Relapsed Acute Leukemia in Children and Adolescents
Status: UNKNOWN
Conditions: Acute Leukemia
Interventions: DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Predictive Study on Acute Radiation Induced Oral Mucositis in Nasopharyngeal Carcinoma Patients
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma by AJCC V8 Stage|Radiation Induced Mucositis
Interventions: OTHER: Intervention based on key factors identified by the severe RIOM prediction model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategies for Prescribing Analgesics Comparative Effectiveness Trial
Status: COMPLETED
Conditions: Back Pain|Osteoarthritis
Interventions: OTHER: Opioid-intensive prescribing strategy|OTHER: Opioid-avoidant prescribing strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine 750-2000 mg/d in the Treatment of Manic Episodes of Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: Licarbazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ImmPACT Expanded Multiple Antigen Specific Endogenously Derived T Cells (MASE-T) to Patients With Metastatic Melanoma
Status: TERMINATED
Conditions: Malignant Melanoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|BIOLOGICAL: Multiple Antigen Specific Endogenously derived T cells|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare PK, PD and Safety of the AD-213-B and AD-2132
Status: COMPLETED
Conditions: Gastroesophagus Reflux Disease
Interventions: DRUG: AD-213-B|DRUG: AD-2132
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ingested Cannabidiol in Healthy Occasional Cannabis Users
Status: COMPLETED
Conditions: Cannabis
Interventions: DRUG: cannabis 0 mg, placebo|DRUG: Cannabis 20 mg,|DRUG: Cannabis 50 mg|DRUG: Cannabis 100 mg|DRUG: Cannabis 200 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Cardio-metabolic Responses to Montmorency Tart Cherry Supplementation in Metabolic Syndrome Patients
Status: COMPLETED
Conditions: Metabolic Syndrome|Insulin Resistance|Hypertension
Interventions: DIETARY_SUPPLEMENT: Montmorency Tart Cherry Capsules|DIETARY_SUPPLEMENT: Montmorency Tart Cherry Juice|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of SHR-1314 in Patients With Active Ankylosing Spondylitis
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DRUG: SHR-1314|DRUG: SHR-1314|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of Response-adapted Strategy in Follicular Lymphoma
Status: COMPLETED
Conditions: Follicular Non-Hodgkin's Lymphoma
Interventions: DRUG: R-CHOP or R-bendamustine|DRUG: Observation|DRUG: Maintenance weekly x4|DRUG: Ibritumomab Tiuxetan + Maintenance|DRUG: Standard Maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of 123I-MIP-1072 SPECT/CT Imaging With Optional Compact Gamma Camera Probe Imaging in Men With Prostate Cancer Undergoing Prostatectomy
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: 123I-MIP-1072
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sorafenib and Erlotinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Has Not Responded to Chemotherapy
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: sorafenib tosylate|GENETIC: DNA analysis|GENETIC: mutation analysis|GENETIC: polymerase chain reaction|GENETIC: protein analysis|GENETIC: protein expression analysis|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MATRIX: Measuring Neutralizing Antibodies in the Patients Treated With Interferon Beta 1a IM, in Mexico and Colombia
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: OTHER: clinical and neurological evaluation|OTHER: Blood Sample|GENETIC: Blood Sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Ejaculation Preservation After Laser Enucleation Prostate
Status: TERMINATED
Conditions: Prostate Hyperplasia
Interventions: PROCEDURE: HoLEP with median lobe preservation|PROCEDURE: HoLEP classic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating Lu AG09222 With Ubrogepant in Participants With Migraine
Status: NOT_YET_RECRUITING
Conditions: Migraine
Interventions: DRUG: Ubrogepant|DRUG: Lu AG09222|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Heating Precondition of Streamlined Liner of the Pharynx Airway Decrease the Incidence of Sore Throat
Status: UNKNOWN
Conditions: Complication of Artificial Airway
Interventions: OTHER: heating precondition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dexmedetomidine Versus Propofol for Sedation in Stereotactic Brain Biopsy
Status: COMPLETED
Conditions: Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Primarily Acting on the Respiratory System
Interventions: DRUG: dexmedetomidine/ propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Activity and Safety of Combination Between Cabozantinib and Temozolomide in Lung and GEP-NENS Progressive After Everolimus, Sunitinib or PRRT (CABOTEM)
Status: RECRUITING
Conditions: Lung Neuroendocrine Neoplasm|GEP Neuroendocrine Tumor
Interventions: DRUG: Cabozantinib and Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Men Study of Single Oral Doses of ASP1941 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ASP1941|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Abiraterone Acetate Plus Low-Dose Prednisone Plus Androgen Deprivation Therapy (ADT) Versus ADT Alone in Newly Diagnosed Participants With High-Risk, Metastatic Hormone-Naive Prostate Cancer (mHNPC)
Status: COMPLETED
Conditions: Prostate Neoplasms
Interventions: DRUG: Abiraterone acetate|DRUG: Prednisone|OTHER: Androgen deprivation therapy (ADT)|DRUG: Abiraterone acetate Placebo|DRUG: Prednisone Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Backward Walking Versus Balance Training in Chronic Ankle Instability Patients
Status: COMPLETED
Conditions: Chronic Ankle Instability
Interventions: DEVICE: Backward Walking Training|DEVICE: Balance Training|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prehospital Triage of Patients With Suspected Non-ST-segment Elevation Acute Coronary Syndrome: the TRIAGE-ACS Study
Status: COMPLETED
Conditions: ACS|NSTEMI - Non-ST Segment Elevation MI|Unstable Angina
Interventions: DIAGNOSTIC_TEST: PreHEART
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: KPT-330 to Treat Poorly Differentiated Lung and Gastroenteropancreatic Tumors
Status: COMPLETED
Conditions: Carcinoma, Neuroendocrine
Interventions: DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Tolerance and Pharmacokinetics of TQB3804 in Subjects With Advanced Malignant Tumors
Status: UNKNOWN
Conditions: Advanced Malignant Tumors
Interventions: DRUG: TQB3804
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Multi-branched Thoracoabdominal Stent Graft System for Thoracoabdominal Aortic Aneurysm.
Status: RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysms
Interventions: DEVICE: Multi-Branched Thoracoabdominal Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of the Tailored Therapy Based on Antimicrobial Susceptibility for 2nd Eradication of H. Pylori
Status: COMPLETED
Conditions: Helicobacter Infection
Interventions: PROCEDURE: H. pylori culture and antimicrobial susceptibility test|DRUG: 14 day PBMT group|DRUG: 14 day MEA group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Metformin|DRUG: L-Arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immuno-bridging Study of COVID-19 Protein Subunit Recombinant Vaccine
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: COVID-19 Protein Subunit Recombinant Vaccine|BIOLOGICAL: Active Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Microneedling With Vitamin C Versus Injectable Vitamin C for Depigmentation in Gingival Melanin Hyperpigmentation
Status: NOT_YET_RECRUITING
Conditions: Gingival Pigmentation
Interventions: PROCEDURE: Microneedling will be done with application of topical vitamin C paste for depigmentation|PROCEDURE: Vitamin C injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19
Status: TERMINATED
Conditions: COVID-19|Acute Respiratory Distress Syndrome|Severe Acute Respiratory Syndrome (SARS)|Coronavirus Infections
Interventions: DRUG: Naltrexone|DRUG: Ketamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Efficacy of Dellegra in Exposure Unit
Status: COMPLETED
Conditions: Rhinitis Allergic
Interventions: DRUG: Fexofenadine HCl 30 mg+Pseudophedrine HCl 60 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Contact-Force-Sensing-Based Radiofrequency Catheter Ablation in Paroxysmal Supraventricular Tachycardias
Status: UNKNOWN
Conditions: Tachycardia; Paroxysmal, Supraventricular|Tachycardia, Supraventricular
Interventions: PROCEDURE: Standard catheter ablation|PROCEDURE: Contact Force-sensing-based catheter ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aromatherapy With Lavender Essential Oil as a Complementary Treatment for the Control of Dental Anxiety
Status: UNKNOWN
Conditions: Dental Anxiety
Interventions: OTHER: Lavender aromatherapy|OTHER: Sham aromatherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Body Composition and Metabolic Risk Parameters by Life Style Intervention.
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome
Interventions: BEHAVIORAL: health education|BEHAVIORAL: food supplementation|BEHAVIORAL: food supplementation combined with physical activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Evolocumab in Ischemic Stroke
Status: NOT_YET_RECRUITING
Conditions: Ischemic Stroke, Acute
Interventions: DRUG: Evolocumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Pharmacotherapy for Alcohol Dependence: Olanzapine
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: 2.5 mg Olanzapine|DRUG: 5mg Olanzapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
Status: RECRUITING
Conditions: Leukopenia|Neutropenia|Infections|Warts|Myelokathexis
Interventions: DRUG: Mozobil (TM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Patients With Depression and Non-suicidal Self-injury
Status: RECRUITING
Conditions: Depressive Disorder, Major|Self-Injurious Behavior
Interventions: PROCEDURE: Transcranial Magnetic Stimulation (TMS)|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate MEDI-524 In Children With Hemodynamically Significant Congenital Heart Disease
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: BIOLOGICAL: Motavizumab|BIOLOGICAL: Palivizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DRUG: Caffeine|DRUG: Warfarin sodium|DRUG: Omeprazole|DRUG: Metoprolol|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Inflammatory and Endothelial Function Response, and Arrhythmia Recurrence Following Catheter Ablation for Atrial Fibrillation
Status: WITHDRAWN
Conditions: Paroxysmal Atrial Fibrillation|Persistent Atrial Fibrillation
Interventions: DEVICE: Cryoballoon ablation|DEVICE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bypassing Anesthesiologist Assessment Before Cataract Surgery: a Non Inferiority Study
Status: TERMINATED
Conditions: Cataract
Interventions: OTHER: nurses perform presurgical assessement and surveillance during surgery|OTHER: the anesthetic team performs presurgical assessement and surveillance during surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Registry Type Study to Monitor for Adverse Drug Reactions to Fedoruk Manufactured [F-18]-Fludeoxyglucose
Status: COMPLETED
Conditions: Positron-Emission Tomography and Cone-Beam Computed Tomography
Interventions: DRUG: [F-18]-Fludeoxyglucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Metronidazole Pharmacokinetics (PK) in Premature Infants
Status: COMPLETED
Conditions: Serious Systemic Infections|Necrotizing Enterocolitis
Interventions: DRUG: Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of 24 Hour Spirometry Profiles of Inhaled BI 1744 CL and Inhaled Foradil in Patients With Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: BI 1744|DRUG: bi1744|DRUG: Placebo|DRUG: Foradil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Delayed Nausea A Phase III Double-Blind Placebo-Controlled Clinical Trial
Status: COMPLETED
Conditions: Nausea
Interventions: DRUG: aprepitant|DRUG: dexamethasone|DRUG: granisetron hydrochloride|DRUG: palonosetron hydrochloride|DRUG: prochlorperazine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Esophageal Cancer Risk Registry
Status: RECRUITING
Conditions: Esophageal Cancer|Gastroesophageal Reflux Disease (GERD)|Esophageal Diseases|Hiatal Hernia|Esophageal Achalasia
Interventions: PROCEDURE: Survey of client health, personal habits, family history|PROCEDURE: Blood specimen for non-DNA and DNA parts|PROCEDURE: Biopsy of esophageal/stomach tissue, lymph nodes, tumor|PROCEDURE: Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Functional Magnetic Resonance Imaging (fMRI) and Robot-Assisted Practice of Activities of Daily Living
Status: COMPLETED
Conditions: Hemiparesis|Ischemic Stroke|Chronic
Interventions: DEVICE: Robot Therapy Device|BEHAVIORAL: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of a Virtual Diabetes Self-Care and Education Program on Diabetes-related Outcomes in Latinos With T2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Virtual Diabetes Self-Care and Education Program|DEVICE: Fitbit|DEVICE: Smartphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT