pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bevacizumab in Multiple Phase I Combinations
Status: COMPLETED
Conditions: Advanced Cancer
Interventions: DRUG: Bevacizumab|DRUG: Sorafenib|DRUG: Erlotinib|DRUG: Trastuzumab|DRUG: Lapatinib|DRUG: Sunitinib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone to Target Stress and Immune System Mechanisms Underlying Alcohol Craving
Status: UNKNOWN
Conditions: Alcohol Use Disorder
Interventions: DRUG: Dexamethasone Oral|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bioavailability of Phenolic Compounds From Oxxynea®
Status: COMPLETED
Conditions: Dietary Modification
Interventions: DIETARY_SUPPLEMENT: Oxxynea®|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
Status: COMPLETED
Conditions: Cardiovascular Diseases|Cardiovascular Risk Factor|Vasoconstriction
Interventions: DRUG: Control (Phenylephrine)|DRUG: Phenylephrine + Apocynin|DRUG: Phenylephrine + Allopurinol|DRUG: Phenylephrine + Tempol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Technique of Restriction of Blood Flow Associated With the Ergonomic Cycle of Upper Limbs in Women
Status: COMPLETED
Conditions: Women's Health: Female Athlete/Female Athlete Triad
Interventions: OTHER: Experimental group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Retaining Retractor in Obese Patients Undergoing Cesarean Section
Status: COMPLETED
Conditions: Pregnancy|Obese
Interventions: DEVICE: Alexis O C-Section Retractor|OTHER: Control- Conventional retractors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: An Expanded Safety Study of Dapivirine Gel 4789 in Africa
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome|Healthy
Interventions: DRUG: dapivirine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Sensory Attributes of Olopatadine 0.6% and Azelastine 137mcg Nasal Sprays in Patients w/Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Olopatadine 0.6% / Azelastine 137 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mazindol Controlled Release in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: mazindol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of Laparoscopy-assisted D2 Distal Gastrectomy to Treat Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: laparoscopy assisted distal gastrectomy|PROCEDURE: open distal gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Merimepodib (MMPD) in Triple Combination for the Treatment of Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C|Hepatitis
Interventions: DRUG: Merimepodib|DRUG: PEG-Interferon-alpha 2a (Pegasys®)|DRUG: Ribavirin (Copegus®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Status: RECRUITING
Conditions: Traumatic Brain Injury|Major Depressive Disorder|Bipolar Disorder|Schizophrenia|Attention Deficit Hyperactivity Disorder|Borderline Personality Disorder|Substance Use Disorders
Interventions: DEVICE: Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acromio-clavicular Dislocation Type III - Conservative Treatment Versus Surgical Hook Plate Treatment
Status: UNKNOWN
Conditions: Acromio-clavicular Joint Dislocation (Type III)
Interventions: OTHER: Conservative treatment - brace|DEVICE: Hook plate by Synthes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Airway Pressure Release Ventilation in Acute Lung Injury
Status: TERMINATED
Conditions: Acute Lung Injury|Acute Respiratory Distress Syndrome|Mechanical Ventilation
Interventions: DEVICE: APRV|DEVICE: Conventional MV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-angiOpoeitin 2 Plus Anti-vascular eNdothelial Growth Factor as a therapY for Neovascular Age Related Macular Degeneration: Evaluation of a fiXed Combination Intravitreal Injection
Status: COMPLETED
Conditions: Neovascular Age-Related Macular Degeneration
Interventions: DRUG: REGN910-3|DRUG: Intravitreal Aflibercept Injection (IAI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tovorafenib (DAY101) Monotherapy or in Combination With Other Therapies for Patients With Melanoma and Other Solid Tumors
Status: RECRUITING
Conditions: Melanoma|Solid Tumor|CRAF Gene Amplification|RAF1 Gene Amplification|BRAF Gene Fusion|BRAF Fusion|CRAF Gene Fusion|CRAF Fusion|RAF1 Gene Fusion|RAF1 Fusion|Thyroid Cancer, Papillary|Spitzoid Melanoma|Pilocytic Astrocytoma|Pilocytic Astrocytoma, Adult|Non Small Cell Lung Cancer|Non-Small Cell Adenocarcinoma|Colorectal Cancer|Pancreatic Acinar Carcinoma|Spitzoid Malignant Melanoma|Bladder Cancer|Bladder Urothelial Carcinoma|MAP Kinase Family Gene Mutation|RAS Mutation|RAF Mutation|MEK Mutation
Interventions: DRUG: Tovorafenib|DRUG: Pimasertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab and Rituximab in Treating Patients With High-Risk, Early-Stage Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Alemtuzumab|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GnRHa + Letrozole in Obese Progestin-insensitive Endometrial Atypical Hyperplasia Patients
Status: RECRUITING
Conditions: Atypical Endometrial Hyperplasia|Progesterone Resistance|Obesity
Interventions: DRUG: GnRH antagonist|DRUG: Letrozole 2.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Connecticut Child STEPs
Status: COMPLETED
Conditions: Anxiety|Depression|Trauma|Behavior Problems
Interventions: BEHAVIORAL: Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, and Conduct Problems|OTHER: Monitoring and Feedback System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of AVTX-002 for the Treatment of Poorly Controlled Non-Eosinophilic Asthma.
Status: COMPLETED
Conditions: Non-Eosinophilic Asthma
Interventions: DRUG: AVTX-002|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Evaluation of Perineal Mechanical Properties During Childbirth
Status: UNKNOWN
Conditions: Perineum; Rupture|Perineum; Tear|Perineal Tear
Interventions: OTHER: assessment in the 8th month of pregnancy and during delivery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ESTD vs. VATS for Upper Gastrointestinal Submucosal Tumors
Status: UNKNOWN
Conditions: Upper Gastrointestinal Submucosal Tumors (SMTs)|Gastrointestinal Stromal Tumors (GISTs)|Leiomyoma
Interventions: PROCEDURE: ESTD|PROCEDURE: VATS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Booster Dose (50 µg) of Recombinant Ricin Toxin Vaccine (RVEc™) in Previously Vaccinated Healthy Adults
Status: COMPLETED
Conditions: Ricin Poisoning
Interventions: BIOLOGICAL: 50-μg booster dose RVEc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia
Status: COMPLETED
Conditions: Acute Undifferentiated Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: DRUG: tanespimycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis
Status: RECRUITING
Conditions: Mucopolysaccharidosis Disorders|Hurler Syndrome|Hunter Syndrome|Maroteaux Lamy Syndrome|Sly Syndrome|Alpha-Mannosidosis|Fucosidosis|Aspartylglucosaminuria|Glycoprotein Metabolic Disorders|Sphingolipidoses|Recessive Leukodystrophies|Globoid Cell Leukodystrophy|Metachromatic Leukodystrophy|Niemann-Pick B|Niemann-Pick C Subtype 2|Sphingomyelin Deficiency|Peroxisomal Disorders|Adrenoleukodystrophy With Cerebral Involvement|Zellweger Syndrome|Neonatal Adrenoleukodystrophy|Infantile Refsum Disease|Acyl-CoA Oxidase Deficiency|D-Bifunctional Enzyme Deficiency|Multifunctional Enzyme Deficiency|Alpha-methylacyl-CoA Racmase Deficiency|Mitochondrial Neurogastrointestingal Encephalopathy|Severe Osteopetrosis|Hereditary Leukoencephalopathy With Axonal Spheroids (HDLS; CSF1R Mutation)|Inherited Metabolic Disorders
Interventions: BIOLOGICAL: Stem Cell Transplantation|DRUG: IMD Preparative Regimen|DRUG: Osteopetrosis Only Preparative Regimen|DRUG: Osteopetrosis Haploidentical Only Preparative Regimen|DRUG: cALD SR-A (Standard-Risk, Regimen A)|DRUG: cALD SR-B (Standard-Risk, Regimen B)|DRUG: cALD HR-D (High-Risk, Regimen C)|DRUG: cALD HR-D (High-Risk, Regimen D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Symprove (Probiotic) as an add-on to COVID-19 Management
Status: UNKNOWN
Conditions: Covid19
Interventions: OTHER: Symprove (probiotic)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adipokines in Obese Adolescents With Insulin Resistance
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and Epacadostat With Platinum Doublet Chemotherapy Versus Platinum Doublet Chemotherapy in Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: Nivolumab|DRUG: Epacadostat|DRUG: Placebo|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Gemcitabine|DRUG: Paclitaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics and Safety Profiles After Administration of DA-5218 and Co-administration of DA-5218-R1, DA-5218-R2 and DA-5218-R3 in Healthy Adult Volunteers
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: DA-5218|DRUG: DA-5218-R1 + DA-5218-R2 + DA-5218-R3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GS-5829 in Combination With Fulvestrant or Exemestane in Women With Advanced Estrogen Receptor Positive, HER2 Negative-Breast Cancer
Status: TERMINATED
Conditions: Advanced Estrogen Receptor Positive HER2- Breast Cancer
Interventions: DRUG: GS-5829|DRUG: Exemestane|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of the Anti-Programmed Death Ligand-1 Durvalumab Antibody (MEDI4736) in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Can...
Status: RECRUITING
Conditions: Colorectal Neoplasms|Breast Neoplasms
Interventions: DRUG: Olaparib|DRUG: Cediranib|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study Of Exercise And Vitamin D In Frail Elderly Subjects
Status: TERMINATED
Conditions: Elderly, Frail
Interventions: DRUG: Vitamin D + Sham Exercise|PROCEDURE: Vitamin D Placebo + Exercise|PROCEDURE: Vitamin D Placebo + Sham Exercise|DRUG: Vitamin D + Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Thrower's Ten and Routine Physical Therapy in Patients With Shoulder Impingement Syndrome
Status: RECRUITING
Conditions: Shoulder Impingement Syndrome
Interventions: OTHER: Thrower's Ten Exercise Program|OTHER: Routine physical therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing a Technology-based Body and Mind Intervention
Status: RECRUITING
Conditions: Fall|Fear of Falling|Physical Inactivity|Sedentary Behavior
Interventions: BEHAVIORAL: Physio-feedback|BEHAVIORAL: Cognitive reframing|BEHAVIORAL: Peer-led exercises|BEHAVIORAL: CDC older adults fall prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of a Video Game Intervention to Recalibrate Physician Heuristics: A Followup Study
Status: COMPLETED
Conditions: Wounds and Injuries
Interventions: BEHAVIORAL: Video game|BEHAVIORAL: Educational program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures
Status: COMPLETED
Conditions: Urinary Tract Diseases
Interventions: DRUG: Exparel|DRUG: Marcaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Celgene High Risk Multiple Myeloma (MM) Revlimid Induction and Maintenance Therapy
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Lenalidomide Induction|DRUG: Sequential Maintenance Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Cross-sectional Study of Cardiac Ultrasound Phenotypes in Patients With Sepsis
Status: ENROLLING_BY_INVITATION
Conditions: Cardiac Ultrasound Phenotypes|Septic Myocardial Suppression|Hyperdynamic State Left Ventricular Function in Sepsis Patients|Outcome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oxygen-Enhanced MRI for Generating Hypoxia Maps in Patients With Intracranial Tumors
Status: RECRUITING
Conditions: Intracranial Neoplasm
Interventions: PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Oxygen Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: BARBED vs. STANDARD Suture for Colporrhaphy at the End of Laparoscopic Hysterectomy
Status: NOT_YET_RECRUITING
Conditions: Vaginal Cuff Complications
Interventions: PROCEDURE: Laparoscopic colporrhaphy with 0-caliber barbed absorbable suture|PROCEDURE: Laparoscopic colporrhaphy with standard 0-caliber absorbable suture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRogram In Support of Moms: An Innovative Stepped-Care Approach for Obstetrics and Gynecology Clinics
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: PRogram In Support of Moms (PRISM)|BEHAVIORAL: MCPAP for Moms
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Subconcussive Head Impacts on Neural Integrity and Function in ADHD
Status: COMPLETED
Conditions: Sport Injury|Attention-deficit/Hyperactivity Disorder
Interventions: OTHER: Soccer Heading|OTHER: Soccer Heading
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prevention of Post-exercise Muscle Fatigue and Effect on Exercise Training in Severe Patients With COPD.
Status: COMPLETED
Conditions: Obstructive Lung Diseases
Interventions: DEVICE: Inspiratory help then sham ventilation|DEVICE: Sham ventilation then Inspiratory help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Safety and Tolerability Study of BDB-001 in Mild, Moderate COVID-19 Patients
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: BDB-001 injection|DRUG: BDB-001 injection|DRUG: BDB-001 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Subconjunctival Bevacizumab Injection in Impending Recurrent Pterygium
Status: COMPLETED
Conditions: Pterygium of the Conjunctiva and Cornea
Interventions: DRUG: Fluorometholone|DRUG: Bevacizumab|DRUG: Bevacizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trigger-point Blockade in Persistent Pain After Laparoscopical Groin Hernia Repair
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retrospective Data Collection and Prospective Clinical Investigation for the Augmentation or Reinforcement of the Rotator Cuff Using the Pitch-Patch
Status: NOT_YET_RECRUITING
Conditions: Rotator Cuff Tear|Rotator Cuff Tears|Rotator Cuff Tears of the Shoulder|Rotator Cuff Injuries
Interventions: DEVICE: Pitch-Patch
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Cognitive Behavioral Therapy (CBT) Intervention to Reduce Fear of Hypoglycemia in Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Fear Reduction Intervention|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study Comparing Priming Solution Containing Crystalloid or Packed Red Blood Cells in Patients Treated With Isolated Limb Perfusion.
Status: COMPLETED
Conditions: Melanoma|Sarcoma
Interventions: DRUG: Crystalloid based prime solution|DRUG: Erythrocyte based prime solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Docetaxel for Injection (Albumin-bound) in Combination With Nivolumab in Patients With Head and Neck (SCCHN)
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Docetaxel|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Ruxolitinib in Pancreatic Cancer Patients
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Capecitabine|DRUG: Ruxolitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Ramucirumab or Icrucumab in Colorectal Cancer
Status: COMPLETED
Conditions: Colon Cancer|Rectal Cancer
Interventions: BIOLOGICAL: Ramucirumab|BIOLOGICAL: Icrucumab|DRUG: mFOLFOX-6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veliparib in Combination With Carboplatin And Weekly Paclitaxel in Japanese Subjects With Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: veliparib|DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Early PCSK9 Inhibitor Treatment on Heart After Acute Myocardium Infarction
Status: RECRUITING
Conditions: Acute Myocardial Infarction
Interventions: DRUG: alirocumab|OTHER: conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treadmill, Stretching and Proprioceptive Exercise (TreSPE) Rehabilitation Program for Charcot-Marie-Tooth Neuropathy Type 1A (CMT1A)
Status: UNKNOWN
Conditions: Charcot-Marie-Tooth Disease|Charcot-Marie-Tooth Disease Type 1A
Interventions: OTHER: TreSPE|OTHER: SPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Sternal Healing After Cardiac Surgery: Sternal Wire vs ZIPFIX
Status: WITHDRAWN
Conditions: Sternal Injury|Cardiac Surgery|Heart Diseases
Interventions: DEVICE: Steel Wires|DEVICE: ZipFix Sternal Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lymphocytic Enteritis and Suspected Coeliac Disease: Gluten vs Placebo
Status: COMPLETED
Conditions: Celiac Disease|Non-celiac Gluten Sensitivity
Interventions: DIETARY_SUPPLEMENT: Gluten challenge|DIETARY_SUPPLEMENT: Placebo challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Smear Layer on Endodontic Outcome
Status: COMPLETED
Conditions: Apical Periodontitis
Interventions: PROCEDURE: Root canal treatment with smear layer removal|PROCEDURE: Root canal treatment without smear layer removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Clinical Trial to Evaluate the Effect of DWP14012 on the Pharmacokinetics of DWC202201 in Healthy Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Drug Drug Interaction
Interventions: DRUG: DWP14012|DRUG: DWC202201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vein Fitness System vs Compressive Therapy for Venous Ulcers: a Bayesian Adaptive Trial
Status: RECRUITING
Conditions: Varicose Ulcer
Interventions: PROCEDURE: Vein Fitness|PROCEDURE: Compressive therapy and wound care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rotating Pazopanib and Everolimus to Avoid Resistance
Status: COMPLETED
Conditions: Clear Cell Renal Carcinoma
Interventions: DRUG: Pazopanib|DRUG: Everolimus|DRUG: Pazopanib|DRUG: Everolimus|DRUG: Everolimus|DRUG: Pazopanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A PET Study With [11C]PBR-28 and an Experimental Medication, Ethyl Eicosapentaenoic Acid
Status: WITHDRAWN
Conditions: Bipolar Disorder
Interventions: DRUG: Ethyl Eicosapentaenoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Quantitative Changes in Palatal Donor Sites Thickness After Free Gingival Graft Harvesting
Status: COMPLETED
Conditions: Healthy|Gingival Recession
Interventions: OTHER: Less than 2 mm remaining palatal tissue thickness|OTHER: 2 mm or more remaining palatal tissue thickness
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sorafenib Combined With Aspirin to Prevent the Recurrence in High-risk Patients With Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: OTHER: control|DRUG: sorafenib|DRUG: aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercise on Migraine Attacks in Chronic Migraine
Status: COMPLETED
Conditions: Migraine|Chronic Migraine
Interventions: BEHAVIORAL: Combined exercise|BEHAVIORAL: Aerobic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fludarabine, Cyclophosphamide, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Hematologic Cancer
Status: COMPLETED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: DRUG: cyclophosphamide|DRUG: fludarabine phosphate|DRUG: mycophenolate mofetil|DRUG: tacrolimus|PROCEDURE: allogeneic bone marrow transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus)
Status: NOT_YET_RECRUITING
Conditions: Hepatitis B
Interventions: DRUG: Bepirovirsen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerability and PK of Submicron Budesonide in Children 4 to 11 Years Old With Mild-To-Moderate Stable Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: 84ug MAP0020|DRUG: 42ug MAP0020|DRUG: 21ug MAP0020
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Concentrations of Remifentanil for Extubation
Status: COMPLETED
Conditions: Cough
Interventions: DRUG: Extubation U|DRUG: Extubation T
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Conjoint Tendon Resection During Reverse Total Shoulder Arthroplasty
Status: RECRUITING
Conditions: Shoulder Injuries|Patient Satisfaction|Internal Rotation Contracture-shoulder
Interventions: PROCEDURE: Conjoint Tendon Resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tackling 30-day Readmissions in Patients With Cirrhosis: The SALTYFOOD Trial
Status: COMPLETED
Conditions: Hepatic Encephalopathy|Ascites|Liver Diseases|Cirrhosis
Interventions: OTHER: Meal delivery|OTHER: Standard pamphlet with Dietary Advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomised Trial of Intensive Behavioral Lifestyle Intervention Versus Usual Preparation for Bariatric Surgery
Status: RECRUITING
Conditions: Morbid Obesity
Interventions: BEHAVIORAL: Preoperative usual care|BEHAVIORAL: Preoperative intensive behavioral lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With Obesity
Status: RECRUITING
Conditions: Periodontitis|Obesity
Interventions: PROCEDURE: antimicrobial photodynamic therapy (aPDT)|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Taxane Chemotherapy and Nail Toxicity in Women With Breast Cancer; Stage Two: Evaluation of Interventions
Status: UNKNOWN
Conditions: Breast Cancer|Nail Toxicity
Interventions: DEVICE: Onicolife nail drops|OTHER: Nail polish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoablation for the Promotion of Local Tumor Infiltration in Patients With Mesothelioma
Status: WITHDRAWN
Conditions: Mesothelioma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Cryosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Cervical Stabilization Exercises on Hand Grip Strength in Chronic Myofascial Neck Pain
Status: RECRUITING
Conditions: Chronic Neck Pain
Interventions: PROCEDURE: cervical stabilization exercises and integrated neuromuscular technique.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: European platforM to PromOte Wellbeing and HEalth in the Workplace (EMPOWER)
Status: UNKNOWN
Conditions: Stress|Anxiety|Depression|Insomnia
Interventions: DEVICE: A multi-modal and integrative e-health platform aimed at promoting health and reducing the negative impact of mental problems in the workplace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transcriptome and Metabolic Analyses of CHAPLE Disease
Status: UNKNOWN
Conditions: CD55 - Cluster of Differentiation Antigen 55 Deficiency|Primary Intestinal Lymphangiectasis|Protein-Losing Enteropathies|Complement Regulatory Factor Defect
Interventions: DRUG: Eculizumab Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Modified Air-pulse Stimulation on Tracheotomised Patients With Dysphagia After Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Modified Air-pulse Stimulation|BEHAVIORAL: Conventional air-pulse stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety, Tolerability, and Pharmacokinetics (PK) of VH4524184 and the Potential for Changes in Cytochrome P450 3A (CYP3A) Activity
Status: RECRUITING
Conditions: HIV Infections
Interventions: DRUG: VH4524184|DRUG: Midazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paravertebral Block for Postoperative Analgesia in Children Undergoing Lateral Incision Cardiac Surgery With CBP
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: paravertebral block|PROCEDURE: Local infiltration anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Maraviroc on the Immune Function in HIV-1 Infected Subjects Receiving Immunisation With Novel Antigens
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Maraviroc|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of tDCS on Cerebral Autoregulation
Status: COMPLETED
Conditions: Cerebral Microangiopathy|CADASIL|Migraine With Aura|ICA Stenosis
Interventions: DEVICE: Anodal tDCS|DEVICE: Cathodal tDCS|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of 2% IDL Lotion on Skin Hydration and Transepidermal Water Loss in Females With Dry Skin
Status: COMPLETED
Conditions: Xerosis Cutis
Interventions: COMBINATION_PRODUCT: IDL lotion|COMBINATION_PRODUCT: Control lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Famitinib in Patients With Failure of First-Line Treatment For Intrahepatic Cholangiocarcinoma
Status: WITHDRAWN
Conditions: Intrahepatic Cholangiocarcinoma
Interventions: DRUG: Famitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Pelvic Floor Muscle Training and Diaphragmatic Breathing Exercise on Body Posture
Status: UNKNOWN
Conditions: Telerehabilitation|Body Posture|Pelvic Floor Muscle Training|Diaphragmatic Breathing|Quality of Life
Interventions: OTHER: exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)
Status: TERMINATED
Conditions: Obesity|Overweight
Interventions: DRUG: NB32|DRUG: PBO|BEHAVIORAL: Weight Management Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Hypoalgesic Effects of Manipulative Therapy Using Pain Conditioning and Expectations in Low Back Pain
Status: RECRUITING
Conditions: Chronic Low Back Pain
Interventions: PROCEDURE: Procedure/Surgery: Experimental: Hidden conditioning + Positive Expectation|PROCEDURE: Procedure/Surgery: Active Comparator: Positive Expectation|PROCEDURE: Procedure/Surgery: Active Comparator: Neutral Expectation|PROCEDURE: Spinal Manipulative Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Multicenter Study to Evaluate the Performance of Flexima® Active vs. Sensura® in Patients With Colostomy
Status: COMPLETED
Conditions: Colostomy
Interventions: DEVICE: Flexima Active|DEVICE: Sensura
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Trial on Meningococcal B Vaccine for Preventing Gonorrhea Infections
Status: RECRUITING
Conditions: Gonorrhea|Sexually Transmitted Infection
Interventions: BIOLOGICAL: 4CMenB vaccine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia
Status: NOT_YET_RECRUITING
Conditions: Acute Malnutrition, Severe|Malnutrition, Child|Wasting
Interventions: BEHAVIORAL: R-SWITCH integrated intervention package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Gut Hormone Response After Paleolithic-type Meals
Status: COMPLETED
Conditions: Insulin Resistance|Satiety
Interventions: OTHER: PAL-2|OTHER: TFH-1|OTHER: Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single and Repeated Doses of Topical GSK1278863
Status: COMPLETED
Conditions: Wound Healing
Interventions: DRUG: GSK1278863|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of AVR-RD-02 Compared to Enzyme Replacement Therapy for Treatment of Gaucher Disease Type 3
Status: WITHDRAWN
Conditions: Gaucher Disease, Type 3
Interventions: DRUG: Gene therapy|DRUG: Enzyme Replacement Agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Helicobacter Pylori Local Prevalence and Antibiotic Resistance
Status: RECRUITING
Conditions: Helicobacter Pylori Infection|Helicobacter Pylori Gastritis|Drug Resistant Bacterial Infection|Antibiotic Resistant Infection|Gastric Cancer|Microbial Colonization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Building an Equitable and Accessible System of Eating Disorder Care for VA, DoD, and Underrepresented Americans
Status: RECRUITING
Conditions: Binge-Eating Disorder|Bulimia Nervosa|Veterans Health|Cognitive Behavioral Therapy
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With APC8015 (Sipuleucel-T, Provenge) for Asymptomatic, Metastatic, Hormone-Refractory Prostate Cancer
Status: COMPLETED
Conditions: Hormone-Refractory Prostate Cancer
Interventions: BIOLOGICAL: sipuleucel-T|BIOLOGICAL: APC-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Safety and Efficacy of Afalaza in Patients With Symptoms of Benign Prostatic Hyperplasia and Risk of Progression
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Afalaza|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: filgrastim|DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: etoposide|DRUG: leucovorin calcium|DRUG: liposomal cytarabine|DRUG: mercaptopurine|DRUG: mesna|DRUG: methotrexate|DRUG: therapeutic hydrocortisone|DRUG: thiotepa|DRUG: vincristine sulfate|RADIATION: low-LET electron therapy|RADIATION: low-LET photon therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of an Ambulatory Medical Abortion Service at 13-18 Weeks of Gestation in Colombia
Status: TERMINATED
Conditions: Second Trimester Abortion
Interventions: DRUG: Mifepristone|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating to Reduce Albuminuria and Normalize Hemodynamic Function in Focal ScLerosis With dApagliflozin Trial Effects
Status: COMPLETED
Conditions: Focal Segmental Glomerulosclerosis
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease
Status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Diseases|Hypertension|Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Propolis + Royal Jelly|DIETARY_SUPPLEMENT: Royal Jelly|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Myocardial Blood Volume Measurement by Real-Time Myocardial Perfusion Echocardiography Correlates to Myocardial Compressibility by Cardiac Magnetic Resonance Imaging in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DIAGNOSTIC_TEST: Real-Time Myocardial Echocardiography (RTMPE)|DIAGNOSTIC_TEST: Magnetic resonance image (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Researching Emotions And Cardiac Health: Phase III
Status: COMPLETED
Conditions: Congestive Heart Failure|Emotions|Patient Compliance
Interventions: BEHAVIORAL: PP-based health behavior intervention|BEHAVIORAL: MI-based educational control condition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Research on Changes in Intestinal Barrier Function and Gut Microbiome in Patients With Type 2 Diabetes After Duodenal Mucosal Resurfacing (DMR)
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes Mellitus
Interventions: PROCEDURE: DMR Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Asenapine With Placebo and Haloperidol (41023)(P05926)(COMPLETED)
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Asenapine|DRUG: Asenapine|DRUG: Haloperidol|OTHER: Placebo arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria
Status: TERMINATED
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: Cemdisiran|DRUG: Eculizumab|DRUG: Pozelimab|DRUG: Ravulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Mild and Moderate Hepatic Impairment on the Single-Dose Pharmacokinetics of Rilzabrutinib (PRN1008)
Status: COMPLETED
Conditions: Hepatic Function Abnormal|Healthy Volunteers
Interventions: DRUG: Rilzabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Rosiglitazone and Alpha-lipoic Acid on the Patients With Pathologically Proved NASH
Status: TERMINATED
Conditions: NASH (Non-alcoholic Steato-hepatitis)
Interventions: DRUG: Rosiglitazone|DRUG: alpha-lipoic acid|DRUG: Rosiglitazone/alpha-lipoic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Erector Spinae Block Versus PENG Block for Hip Replacement
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: ERECTOR SPINAE PLANE BLOCK|PROCEDURE: Peng block + lateral femoral cutaneous nerve block|PROCEDURE: spinal anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Endoscope Imaging in Colonoscopy: Influence on Propofol Dosage
Status: COMPLETED
Conditions: Failed Conscious Sedation During Procedure
Interventions: DEVICE: Magnetic Endoscope Imaging (Scope Guide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION