pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Long Term Effect of Inhaled Hypertonic Saline (6%) in Patients With Non Cystic Fibrosis Bronchiectasis
Status: COMPLETED
Conditions: Bronchiectasis
Interventions: DRUG: Hypertonic saline 6% -
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Prescription and Lifestyles Modification to Reduce Glycemia in People With Prediabetes (PREDIBAL)
Status: UNKNOWN
Conditions: PreDiabetes
Interventions: BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Pabolizumab for Neoadjuvant Immunotherapy of Locally Advanced Microsatellite-unstable Gastric Adenocarcinoma
Status: RECRUITING
Conditions: Gastric Cancer|Gastric Adenocarcinoma
Interventions: DRUG: pabolizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability and Immunogenicity of a Plant-made H7 Virus-like Particle (VLP) Influenza Vaccine in Adults.
Status: COMPLETED
Conditions: Virus Diseases|RNA Virus Infections|Respiratory Tract Diseases|Respiratory Tract Infections
Interventions: BIOLOGICAL: Low dose of H7 VLP vaccine + Alhydrogel|BIOLOGICAL: Med dose of H7 VLP vaccine + Alhydrogel|BIOLOGICAL: High dose of H7 VLP vaccine + Alhydrogel|BIOLOGICAL: High dose of H7 VLP vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Telemedicine Clinical Trial for Cognitive Behavioral Therapy in Familial Dysautonomia
Status: WITHDRAWN
Conditions: Familial Dysautonomia
Interventions: BEHAVIORAL: CBT sessions|BEHAVIORAL: Talking Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Individualized Therapy for CRCs With Secondary RESISTance Towards Anti-EGFR Targeted Therapy Using an Avatar Model
Status: RECRUITING
Conditions: Colo-rectal Cancer|RAS Wild-type|UICC III|UICC II + RF|UICC IV Curative Intent
Interventions: DRUG: targeted substance according to the avatar model
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PH Metry Study to Compare the Antacid Activity of Z0063 Versus Gaviscon Double Action Tablets, in Healthy Adult Subjects
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Z0063|DRUG: Gaviscon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intervention Effectiveness in Improving Psychosocial and Economic Well-being of Sexual Violence Survivors in DRC
Status: COMPLETED
Conditions: Depression|Anxiety|PTSD
Interventions: BEHAVIORAL: Treatment as usual|BEHAVIORAL: Voluntary Savings/Loans Assoc|BEHAVIORAL: Cognitive Processing Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Recombinant Adeno-Associated Virus Containing the CFTR Gene in the Treatment of Cystic Fibrosis
Status: TERMINATED
Conditions: Cystic Fibrosis
Interventions: GENETIC: tgAAVCF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Neoplasms|Ovarian Neoplasms|Colonic Neoplasms|Prostatic Neoplasms|Uterine Cervical Neoplasms|Leukemia|Lymphoma, Non-Hodgkin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: LCAR-B4822M-02 Cells in Treating Relapsed/Refractory (R/R) Multiple Myeloma
Status: UNKNOWN
Conditions: Refractory or Relapsed Multiple Myeloma
Interventions: DRUG: LCAR-B4822M CAR-T Cell Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Study of the ICON™ Auto Series With and Without SensAwake™ and ThermoSmart™ and Conventional Continuous Positive Airway Pressure in Obstructive Sleep Apnea Patients
Status: TERMINATED
Conditions: Sleep Apnea, Obstructive
Interventions: DEVICE: Conventional CPAP Therapy|DEVICE: Fixed pressure ICON™ without ThermoSmart™|DEVICE: Auto ICON™ with SensAwake™ and ThermoSmart™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab and/or Ipilimumab With or Without Azacitidine in Treating Patients With Myelodysplastic Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia|Myelodysplastic Syndrome|Recurrent Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Ticagrelor Versus Clopidogrel in Asian/KOREAn Patients With Acute Coronary Syndromes Intended for Invasive Management
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Myocardial Ischemia|Heart Diseases|Cardiovascular Diseases|Angina Pectoris
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacytidine Plus FLAG for Relapsed or Refractory AML
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Azacytidine|DRUG: Fludarabine|DRUG: Cytarabine|DRUG: Filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caudal Versus Intravenous Dexmedetomidine for Caudal Analgesia in Children
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Caudal Dexmedetomidine|DRUG: Intravenous dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep in BMT Survivors
Status: COMPLETED
Conditions: Sleep Disturbance|Sleep Disorder
Interventions: OTHER: mHealth Stepped-care Intervention|OTHER: Educational Control Condition|OTHER: Questionnaire|OTHER: Interview|OTHER: Qualitative Interviews|OTHER: Virtual Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Fludeoxyglucose F 18 in Detecting Lymph Node Metastasis in Patients With Stage I or Stage II Non-Small Cell Lung Cancer That Can Be Removed by Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: chemotherapy|PROCEDURE: lymphadenectomy|PROCEDURE: neoadjuvant therapy|PROCEDURE: quality-of-life assessment|PROCEDURE: therapeutic conventional surgery|PROCEDURE: thoracic surgical procedure|RADIATION: fludeoxyglucose F 18|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Studying the Starvation Effect on Androgen Metabolism in 20 Healthy Young Women and Comparison to Women With PCOS.
Status: COMPLETED
Conditions: PCOS Disease
Interventions: OTHER: Androgen metabolism after starvation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: BIOLOGICAL: PF-05280586|BIOLOGICAL: MabThera®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RAD001 and Intravesical Gemcitabine in BCG-Refractory Primary or Secondary Carcinoma In Situ of the Bladder
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Everolimus and Intravesical Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aripiprazole in Adolescents With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Aripiprazole tablet, 10 mg|DRUG: Aripiprazole tablet, 30 mg|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of IGC-AD1 in Subjects With Dementia Due to Alzheimer's Disease
Status: COMPLETED
Conditions: Dementia of Alzheimer Type
Interventions: DRUG: IGC AD1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Respiratory Infections Among Children Under 3 Years of Age Attending Daycare Centres
Status: UNKNOWN
Conditions: Respiratory Tract Infections
Interventions: OTHER: Health education session|OTHER: Nasal clearance Protocol|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy
Status: TERMINATED
Conditions: Locally Advanced Pancreatic Cancer|Adenocarcinoma, Pancreas|Metastatic Pancreatic Cancer
Interventions: DRUG: Clopidogrel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Trial of Dextromethorphan in Rett Syndrome
Status: COMPLETED
Conditions: Rett Syndrome
Interventions: DRUG: dextromethorphan|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autonomic Correlates of Impulsivity for Preschool Children With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: atomoxetine (or placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation
Status: COMPLETED
Conditions: Constipation
Interventions: DRUG: Lubiprostone|DRUG: Senna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nab-paclitaxel in Combination With Gemcitabine in Fragile Patients With Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: Nab-paclitaxel 150 mg/m2 + Gemcitabine 1000 weeks 1,3/4|DRUG: Nab-paclitaxel 100 mg/m2 + Gemcitabine 1000 weeks 1,2,3/4|DRUG: Nab-paclitaxel 125 mg/m2 + Gemcitabine 1000 weeks 1,3/4|DRUG: Nab-paclitaxel 125 mg/m2 + Gemcitabine 1000 weeks 1,2,3/4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Varying Load and Dose of ISIS 301012 in People With Elevated LDL-cholesterol Levels
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo|DRUG: ISIS 301012 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy Following Disc Surgery: Long Term Follow-up of a RCT
Status: COMPLETED
Conditions: Intervertebral Disc Displacement
Interventions: BEHAVIORAL: Physiotherapy Intervention|BEHAVIORAL: Sham neck massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 304-C03/L3301n: Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
Status: UNKNOWN
Conditions: Growth Hormone Deficiency
Interventions: DRUG: growth hormone (Nutropin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Chewing Efficiency of Conventional Complete Denture in Comparison to Reinforced Poly Amide Denture
Status: UNKNOWN
Conditions: Mouth, Edentulous
Interventions: OTHER: polyamide|OTHER: heat cured acrylic resin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Unrelated Donor Stem Cell Transplantation
Status: COMPLETED
Conditions: Severe Aplastic Anemia|Paroxysmal Nocturnal Hemoglobinuria|Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Myelodysplastic Syndromes|Myeloproliferative Syndromes|Chronic Myelogenous Leukemia|Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma|Multiple Myeloma|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Large Granulocytic Leukemia
Interventions: PROCEDURE: Allogeneic transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Research on the Effect of Different Extents of Internal Limiting Membrane Peeling on Macular Hole Closure and Visual Acuity
Status: UNKNOWN
Conditions: Macular Holes
Interventions: PROCEDURE: Large extent of ILM Peeling|PROCEDURE: Small extent of ILM Peeling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Systematic Case Series Investigating Eye Movement Desensitization Reprocessing (EMDR) Efficacy With Childhood Sexual Abuse Survivors
Status: COMPLETED
Conditions: Trauma, Psychological
Interventions: BEHAVIORAL: Eye Movement Desensitization Reprocessing (EMDR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Lumacaftor|DRUG: Ivacaftor|DRUG: Ciprofloxacin|DRUG: Itraconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigating the Use of Drains and (Internal) Quilting Sutures on Seroma Formation Following Mastectomy
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: PROCEDURE: Surgery alone|PROCEDURE: Surgery and Drain(s)|PROCEDURE: Surgery and Quilting Sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractional Flow Reserve (FFR) Versus Intravascular Ultrasound (IVUS) in Intermediate Coronary Artery Disease
Status: TERMINATED
Conditions: Coronary Artery Stenosis
Interventions: DEVICE: Grey scale intravascular ultrasound (Galaxy or Virtual histology-Intravascular Ultrasound)|DEVICE: Pressure wire(Radi Medical Systems)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Mycamine® in Infants and Toddlers With Fungal Infections to Evaluate Safety and Blood Levels of the Drug
Status: COMPLETED
Conditions: Invasive Candidiasis|Esophageal Candidiasis|Oropharyngeal Candidiasis|Candidemia
Interventions: DRUG: Micafungin (Mycamine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effect of Stellate Ganglion Block on Blood Flow in the Cannulated Radial Artery
Status: UNKNOWN
Conditions: Stellate Ganglion Block|Radial Artery Cannulation
Interventions: PROCEDURE: USG stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade
Status: COMPLETED
Conditions: Respiratory Muscles|Electromyography
Interventions: DRUG: Sugammadex|DRUG: Neostigmine|DRUG: Neostigmine-sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Flexitarian, Time-restricted Eating on Cardiometabolic Traits in Normal Weight, Young Men
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiometabolic Syndrome|Glucose Metabolism Disorders|Blood Pressure|Lipid Metabolism Disorders
Interventions: BEHAVIORAL: Dietary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Neuroprotection Effect of Dexmedetomidine
Status: UNKNOWN
Conditions: Dexmedetomidine
Interventions: DRUG: Dexmedetomidine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norway
Status: COMPLETED
Conditions: Opioid Dependence
Interventions: DRUG: Naltrexone intramuscular suspension|DRUG: Buprenorphine-naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Chitosan Nanoparticles on Periodontal Problems Post Steroidal Inhalation in Asthmatic Patients: Phase I Trial
Status: NOT_YET_RECRUITING
Conditions: Periodontal Diseases
Interventions: DRUG: Chitosan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain and Behavior Depending on Timing of Iron Deficiency in Human Infants
Status: COMPLETED
Conditions: Iron Deficiency|Iron Deficiency Anemia
Interventions: DIETARY_SUPPLEMENT: Ferrous Sulfate (liquid) + vitamins A and D|DIETARY_SUPPLEMENT: vitamins A and D|DIETARY_SUPPLEMENT: Ferrous sulfate (liquid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase Ib/II Clinical Study in Patients With Refractory Chronic Cough
Status: NOT_YET_RECRUITING
Conditions: Refractory Chronic Cough
Interventions: DRUG: TCR1672 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Tagraxofusp|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The University of Hong Kong Neurocognitive Disorder Cohort
Status: UNKNOWN
Conditions: Neurocognitive Disorder|Mild Cognitive Impairment|Alzheimer Dementia|Vascular Dementia|Age-related Cognitive Decline
Interventions: DIAGNOSTIC_TEST: Neurocognitive battery|DIAGNOSTIC_TEST: MRI|BIOLOGICAL: Blood tests|DIAGNOSTIC_TEST: EEG with event-related potential (ERP)|DIAGNOSTIC_TEST: Amyloid PET CT
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Observational Retrospective Study on Spinal Analgesia in Laparoscopic and Laparotomic Hysterectomy
Status: COMPLETED
Conditions: Pain, Postoperative|Hysterectomy|Morphine|Anesthesia, Spinal
Interventions: PROCEDURE: Administration of morphine by intrathecal route|PROCEDURE: Administration of morphine by intravenous route
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Identifying Very Early Response to Seroquel Extended Release (XR) Augmentation for Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Quetiapine (Seroquel) XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real World Safety & Efficacy Experience of Empagliflozin With or Without Metformin in T2DM Patients - EASE Study
Status: RECRUITING
Conditions: Type II Diabetes Mellitus|Efficacy, Self|Safety Issues
Interventions: DRUG: Empagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ocular Growth Factors Profile in Proliferative Retinopathies Before and After Intravitreal Bevacizumab
Status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy|Age Related Macular Degeneration
Interventions: DRUG: Avastin intravitreal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate With Vincristine and Dexamethasone in Acute Lymphoblastic Leukemias With BCR-ABL Positive
Status: COMPLETED
Conditions: Leukemia, Lymphocytic, Acute|Philadelphia Chromosome|Blast Crisis|Leukemia, Myeloid, Chronic
Interventions: DRUG: Imatinib mesylate|DRUG: Interferon|DRUG: Vincristine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Cosmetic Effects of Bakuchiol and Retinol
Status: COMPLETED
Conditions: Wrinkle|Photoaging
Interventions: DRUG: Bakuchiol|DRUG: Retinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Single and Multiple Ascending Doses of GATE-101 in Normal Human Volunteers
Status: TERMINATED
Conditions: Major Depressive Disorder|Excessive Sleepiness
Interventions: DRUG: GATE-101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Bevacizumab Alone or in Combination With Irinotecan for Treatment of Glioblastoma Multiforme (BRAIN)
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: bevacizumab|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty
Status: COMPLETED
Conditions: Prosthesis-Related Infections
Interventions: OTHER: Oral Antibiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Time Course of Response to Methylphenidate HCl ER Capsules in Children 6 to 12 Years With ADHD in Classroom Setting
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|ADHD
Interventions: DRUG: Methylphenidate Hydrochloride Extended Release Capsule|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Treatment With Capecitabine in Colorectal Cancer Patients
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Neoplasms Metastasis
Interventions: DRUG: Capecitabine|OTHER: Observation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node in Early-Stage Endometrium Cancer
Status: RECRUITING
Conditions: Sentinel Lymph Node|Endometrial Cancer
Interventions: DIAGNOSTIC_TEST: Sentinel Lymph Node Mapping With Double Tracer and Double Injection Sites in Early-Stage Endometrium Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study on the Treatment of Recurrent Clubfoot With the Tendon Release of Musculi Tibialis Posterior
Status: UNKNOWN
Conditions: Recurrent Clubfoot
Interventions: PROCEDURE: The tendon release of musculi tibialis posterior|PROCEDURE: Anterior tibial tendon transfer(TATT)|PROCEDURE: Achilles tendon lengthing|PROCEDURE: Fascial release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Convective Prewarming System in Prevention of Perioperative Hypothermia
Status: COMPLETED
Conditions: Perioperative Hypothermia
Interventions: DEVICE: Thermoflect [TM] passive insulation|DEVICE: Active prewarming (Thermoflect™/Mistral Air™, TSCI, Amersfoort, NL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis of the Knee|Degenerative Osteoarthritis|Knee Pain Chronic
Interventions: COMBINATION_PRODUCT: Ibuprofen and PRP|COMBINATION_PRODUCT: Acetaminophen and PRP|COMBINATION_PRODUCT: Placebo and PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate EMP22 PD and EMP16 PK Versus Xenical® in Healthy Volunteers
Status: RECRUITING
Conditions: Overweight or Obesity
Interventions: DRUG: Xenical® vs EMP 22|DRUG: EMP 22 vs Xenical®|DRUG: EMP 16 vs Xenical®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Amino Acids Supplementation and Exercise Intervention in Hemodialysis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemodialysis Complication|Malnutrition
Interventions: DIETARY_SUPPLEMENT: ketoanalogue supplementation|OTHER: intradialytic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Transdermal Matrix Patch ZR-02-01 to Treat Chronic, Moderate to Severe Non-Malignant Pain
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Fentanyl Transdermal Matrix Patch ZR-02-01
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of MM-II for Treatment of Knee Pain in Subjects With Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of Knee
Interventions: DRUG: MM-II dose I|DRUG: MM-II dose II|DRUG: MM-II dose III|DRUG: Placebo|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Olaratumab (IMC-3G3) in Previously Treated Participants With Unresectable and/or Metastatic Gastrointestinal Stromal Tumors
Status: TERMINATED
Conditions: Gastrointestinal Stromal Tumor (GIST)
Interventions: BIOLOGICAL: Olaratumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Plus Docetaxel and Cisplatin in Recurrent or Metastatic Oral Squamous Cell Carcinoma Patients
Status: UNKNOWN
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab Plus Docetaxel and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carfilzomib, Cyclophosphamide, Dexamethasone in Transplant Eligible Newly Diagnosed High-risk Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Carfilzomib, , Cyclophosphamide, Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation
Status: RECRUITING
Conditions: Locally Advanced Rectal Carcinoma|Stage II Rectal Cancer AJCC v8|Stage III Rectal Cancer AJCC v8
Interventions: DRUG: Capecitabine|DRUG: 5-fluorouracil|DRUG: Leucovorin calcium|DRUG: Irinotecan|DRUG: Oxaliplatin|RADIATION: Long Course Chemoradiotherapy|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Sigmoidoscopy|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Study of Zafirlukast in Preventing Allergen-induced Signs and Symptoms in Response to Cat Dander Challenge
Status: NOT_YET_RECRUITING
Conditions: Allergy to Cats
Interventions: DRUG: Zafirlukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx)
Status: COMPLETED
Conditions: Lung; Disease, Fibroid (Chronic)
Interventions: DRUG: Ambulatory Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) for Relief of Moderate to Severe Pain in Patients With Osteoarthritis or Low Back Pain Who Require Opioid Treatment for an Extended Period of Time
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Hydrocodone ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway
Status: RECRUITING
Conditions: Advanced Solid Tumor|RAF Mutation|RAS Mutation|NF1 Mutation|Non-Small Cell Lung Cancer|Pancreatic Ductal Adenocarcinoma|Melanoma|BRAF Gene Mutation|CRAF Gene Mutation
Interventions: DRUG: DCC-3084
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and Hyperuricaemia
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Verinurad|DRUG: Allopurinol|DRUG: Placebo for Verinurad|DRUG: Placebo for Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Stepped Care Model to Deliver CBT-I in Community
Status: RECRUITING
Conditions: Insomnia|Sleep Disturbance
Interventions: BEHAVIORAL: Cognitive behavioral therapy for insomnia (CBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Image-guided De-escalation of Neo-adjuvant Chemotherapy in HER2-positive Breast Cancer: the TRAIN-3 Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: PTC-Pz
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of CenteringPregnancy With Mindfulness Skills
Status: COMPLETED
Conditions: Premature Birth|Low Birth Weight|Postpartum Depression
Interventions: BEHAVIORAL: CenteringPregnancy|BEHAVIORAL: CenteringPregnancy with Mindfulness Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Phase III Study to Assess the Efficacy and Safety of SOTB07 in Asthma Patients
Status: TERMINATED
Conditions: Asthma
Interventions: DRUG: SOTB07 200mg|DRUG: SOTB07 400mg|DRUG: SOTB 200mg placebo|DRUG: SOTB 400mg placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia
Status: TERMINATED
Conditions: Epicondylitis, Lateral Humeral|Tennis Elbow
Interventions: DRUG: PRP-L Injection|DRUG: Botox injection|DRUG: Corticoid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Versus Multiple Visits Endodontic Treatment
Status: COMPLETED
Conditions: Periapical Periodontitis
Interventions: DRUG: mixture of metronidazole, ciprofloxacin, and minocycline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy (IMRT) + RAD001 (Everolimus) + Cisplatin for Patients With Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: RADIATION: intensity modulated radiation therapy|DRUG: RAD001 (everolimus) + Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVF Versus Gonadotropin Therapy in Women With CC Resistant PCOS
Status: WITHDRAWN
Conditions: Infertility|Polycystic Ovarian Syndrome
Interventions: PROCEDURE: IVF|DRUG: Gonadotropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Eftilagimod Alpha and Radiotherapy in Neoadjuvant Treatment of Patients With Soft Tissue Sarcoma - EFTISARC-NEO Trial
Status: RECRUITING
Conditions: Neoadjuvant|Immunotherapy|Sarcoma,Soft Tissue|Radiation Therapy
Interventions: DRUG: Pembrolizumab, Eftilagimod alpha
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Epidural Morphine on Shoulder Pain Following Thoracotomy.
Status: TERMINATED
Conditions: Postoperative Pain|Shoulder Pain
Interventions: DRUG: Fentanyl|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post-ERCP Pancreatitis Prevention by Stent Insertion
Status: COMPLETED
Conditions: Post-ERCP Acute Pancreatitis
Interventions: DEVICE: Stent insertion into the main pancreatic duct
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Panitumumab (ABX-EGF) Plus Best Supportive Care Versus Best Supportive Care in Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Metastases
Interventions: OTHER: Best supportive care|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study
Status: UNKNOWN
Conditions: Ampulla of Vater Adenoma
Interventions: PROCEDURE: Endoscopic snare papillectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Cetuximab and Vemurafenib Plus FOLFIRI for BRAF V600E Mutated Advanced Colorectal Cancer (IMPROVEMENT)
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Vemurafenib|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dry Eye Disease in the Vitamin D and Omega-3 Trial (VITAL)
Status: UNKNOWN
Conditions: Dry Eye Disease
Interventions: DRUG: Omega-3 fatty acids (fish oil)|DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3 placebo|DRUG: Fish oil placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Interferon Gamma With Peg-Interferon Alpha 2a and Ribavirin in Non Responders Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peg-interferon alpha 2a (drug)|DRUG: Ribavirin (drug)|DRUG: Interferon gamma (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Copmere Between Bleaching and Laminate Veneers
Status: UNKNOWN
Conditions: Discoloration, Tooth
Interventions: PROCEDURE: Bleaching agent ( BOOST 40%)|PROCEDURE: laminate veneers(lithium-silicate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy
Status: COMPLETED
Conditions: Neurotoxicity|Pain
Interventions: DRUG: gabapentin|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Participants With B-Cell Malignancies
Status: COMPLETED
Conditions: B-cell Malignancies
Interventions: DRUG: Zanubrutinib|DRUG: Fluconazole|DRUG: Diltiazem|DRUG: Voriconazole|DRUG: Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fighting Immunosenescence and Promoting Immunity by a Fasting-mimicking Diet Elderly.
Status: UNKNOWN
Conditions: Frailty|Inflammation|Immune System Disorder
Interventions: DIETARY_SUPPLEMENT: Prolon - FMD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laparoscopic Sleeve Gastrectomy on Insulin Secretion Pattern in Morbidly Obese Patients With Acanthosis Nigricans
Status: UNKNOWN
Conditions: Morbid Obesity|Acanthosis Nigricans|Insulin Resistance|Insulin Sensitivity|Bariatric Surgery Candidate
Interventions: PROCEDURE: LSG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pirfenidone for Restrictive Chronic Lung Allograft Dysfunction
Status: COMPLETED
Conditions: Restrictive Chronic Lung Allograft Dysfunction|Lung Transplant Rejection
Interventions: DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of CC-90011 in Combination With Nivolumab in Subjects With Advanced Cancers
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: CC-90011|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lower Leg Compression in Extended Video Game Play: A Pilot Study
Status: TERMINATED
Conditions: Compression; Vein|Compression; Artery|Sedentary Behavior|DVT of Legs
Interventions: DEVICE: Lower extremity compression garments|BEHAVIORAL: Active break
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Between Unihemispheric and Bihemispheric TCDS in Subacute Ischemic Stroke Patients
Status: COMPLETED
Conditions: Stroke, Ischemic|Stroke, Acute|Stroke, Lacunar|Hemiparesis|Hemiplegia|Motor Activity|Spastic|Spasticity, Muscle|Hemiplegic Gait
Interventions: DEVICE: Transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Versus Investigator's Choice Standard Therapy for Participants With Advanced Esophageal/ Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)
Status: COMPLETED
Conditions: Esophageal Carcinoma|Esophagogastric Junction Carcinoma
Interventions: BIOLOGICAL: pembrolizumab|DRUG: paclitaxel|DRUG: docetaxel|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness of Topical Fluoride in Preventing Deciduous Dental Caries in Preschool Children
Status: COMPLETED
Conditions: Dental Caries in Children
Interventions: DRUG: 1.23% fluoride foam application|DRUG: 2.26% fluoride varnish application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Clinical Trial to Evaluate TQB2858 Injection Combined With Anlotinib Hydrochloride Capsule in the Treatment of Recurrent or Metastatic Advanced Endometrial Carcinoma
Status: UNKNOWN
Conditions: Endometrial Carcinoma
Interventions: DRUG: TQB2858 injection|DRUG: Anlotinib Hydrochloride capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Closed-Loop Hotel Studies With Medtronic PID Controller
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: Medtronic Hybrid Closed-loop System - Android Platform|DEVICE: Medtronic Hybrid Closed-loop Integrated System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GDNF in ideopathicParkinsons Disease
Status: COMPLETED
Conditions: Idiopathic Parkinson Disease
Interventions: DRUG: glial cell line-derived neurotrophic factor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-Dose or Low-Dose Interferon Alfa Compared With No Further Therapy Following Surgery in Treating Patients With Stage III Melanoma
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: recombinant interferon alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia
Status: COMPLETED
Conditions: Hypoxia|Oxygen Therapy|High Flow Nasal Cannula|Ventilation
Interventions: DEVICE: HFNC followed by conventional nasal cannula|DEVICE: Conventional nasal cannula followed by HFNC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled Trial
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: Exparel with Bubivacaine|DRUG: Bupivacaine only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of the Menstrual Cycle on Physical Exercise and Performance
Status: RECRUITING
Conditions: Menstrual Cycle|Exercise|Women's Health|Athletic Performance
Interventions: OTHER: Periodization of training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Preoperative Oral Carbohydrates on Postoperative Insulin Resistance in Patients Undergoing OPCAB(Off- Pump Coronary Artery Bypass Surgery)
Status: COMPLETED
Conditions: Coronary Artery Occlusive Dissease
Interventions: DIETARY_SUPPLEMENT: carbohydrate beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Two Treatments in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: Cabazitaxel|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
Status: COMPLETED
Conditions: Gastrointestinal Injury|Acute Mountain Sickness
Interventions: DIETARY_SUPPLEMENT: FP|DIETARY_SUPPLEMENT: Placebo|OTHER: High altitude|OTHER: Sea level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION