pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
Status: COMPLETED
Conditions: Anovulation
Interventions: DRUG: clomiphene citrate|DRUG: Sildenafil vaginal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of of Docetaxel vs Docetaxel Estramustine in Hormone Refractory Prostatic Cancer
Status: COMPLETED
Conditions: Hormone Resistant Prostate Cancer|Metastatic Prostate Cancer
Interventions: DRUG: docetaxel|DRUG: estramustine|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 Months
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Syncytial Virus|Human Metapneumovirus
Interventions: BIOLOGICAL: mRNA-1345|BIOLOGICAL: mRNA-1365|BIOLOGICAL: Placebo|DRUG: Nimenrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: celecoxib|DRUG: gemcitabine hydrochloride|DRUG: pemetrexed disodium|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Maolactin™ FMR on Exercise Recovery, Inflammation, and Muscle Comfort in an Otherwise Healthy Population
Status: NOT_YET_RECRUITING
Conditions: Post Exercise Inflammation|Exercise Recovery|Muscle Fatigue|Muscle Pain
Interventions: DRUG: Maolactin|DRUG: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population
Status: COMPLETED
Conditions: Fovea Plana|Albinism
Interventions: GENETIC: Genetic analysis|PROCEDURE: Ophthalmologic exam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Iododoxorubicin in Treating Patients With Primary Systemic Amyloidosis
Status: TERMINATED
Conditions: Primary Systemic Amyloidosis
Interventions: DRUG: 4'-iodo-4'-deoxydoxorubicin|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Anti-PD-1 Antibody SHR-1210 Plus Apatinib vs SHR-1210 as Second-Line Treatment of Advanced Esophageal Squamous Cell
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: DRUG: Camrelizumab|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Combining Physical Exercise and Cognitive Training for the Community-based Elderly
Status: UNKNOWN
Conditions: Cognitively-normal|Mild Cognitive Impairment|Subjective Cognitive Decline
Interventions: BEHAVIORAL: perform physical exercise|BEHAVIORAL: cognitive training|BEHAVIORAL: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Effect of Intranasal Teriparatide on Bone Mineral Density in Postmenopausal Women With Low BMD
Status: WITHDRAWN
Conditions: Osteopenia|Osteoporosis
Interventions: DRUG: Teriparatide|DRUG: Teriparatide Nasal Spray|DRUG: Teriparatide Nasal Spray|DRUG: Teriparatide Nasal Spray|DRUG: Teriparatide Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dietary Omega-3 Fatty Acids on Reproductive Hormones in Obese Women
Status: COMPLETED
Conditions: Obesity|Fertility
Interventions: DIETARY_SUPPLEMENT: LOVAZA|DRUG: GnRH
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Colon Capsule Endoscopy in Patients With Colonic Diverticulitis
Status: ENROLLING_BY_INVITATION
Conditions: Diverticulitis, Colonic
Interventions: DIAGNOSTIC_TEST: colon capsule endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dialysis Recovery Time: Associated Factors and Its Relation to Quality of Life
Status: COMPLETED
Conditions: Dialysis; Complications
Interventions: OTHER: Quality of life assessment using the Kidney Disease Quality of Life 36 (KDQOL-36) short form and Malnutrition-Inflammation Score
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 2A Study of GM 608 in Mild to Moderate Parkinson Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: GM608|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect
Status: COMPLETED
Conditions: Dental Caries|Periodontal Diseases
Interventions: DIETARY_SUPPLEMENT: 100% Xylitol Gum|DIETARY_SUPPLEMENT: 22% Xylitol Gum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Direct Current Stimulation (tDCS) as Treatment Method for Pain in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: tDCS NeuroConn DC-stimulator plus|DEVICE: sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KT® in Patients With Cervical Spine Surgery
Status: COMPLETED
Conditions: Pain|Cervical Spinal Stenosis|Disc, Herniated|Cervical Spondylosis
Interventions: OTHER: Kinesio Taping|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Tumor Tissue From Patients With Melanoma Treated on Clinical Trial EST-1690
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: GENETIC: RNA analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymerase chain reaction|OTHER: immunohistochemistry staining method|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma
Status: TERMINATED
Conditions: Lymphoma|Precancerous/Nonmalignant Condition
Interventions: BIOLOGICAL: PEG-interferon alfa-2b|BIOLOGICAL: Interferon alfa-2b|DRUG: Valproic Acid|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Selinexor in Combination With Pembrolizumab in Recurrent Advanced Melanoma
Status: TERMINATED
Conditions: Locally Advanced Unresectable or Metastatic Melanoma
Interventions: DRUG: Selinexor|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telemedicine Monitoring of Sleep Apnea in Stroke
Status: COMPLETED
Conditions: Stroke|Sleep Apnea
Interventions: DEVICE: Auto CPAP AirSense™ 10(Resmed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intracranial Pressure in Experimental Models of Headache
Status: COMPLETED
Conditions: High Altitude Headache
Interventions: DRUG: Acetazolamide|DRUG: Lactose monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma|Recurrent Brain Neoplasm
Interventions: BIOLOGICAL: Anti-LAG-3 Monoclonal Antibody BMS 986016|BIOLOGICAL: Anti-PD-1|OTHER: Pharmacological Study|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Anti-CD137
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Using the iVAPS Mode
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: DEVICE: Non-invasive home ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Use of Indocyanine Green in Pediatric Colorectal Surgery
Status: RECRUITING
Conditions: Hirschsprung Disease|Anorectal Malformations
Interventions: DRUG: Indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults
Status: COMPLETED
Conditions: Methemoglobinemia|Congenital Methemoglobinemia
Interventions: DRUG: Methylene Blue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Efficacy Study to Evaluate Subjects With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment, So Stated
Interventions: DRUG: AL-108|DRUG: AL-108|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Risk for Infective Endocarditis
Status: RECRUITING
Conditions: Bacteremia|Infective Endocarditis
Interventions: BEHAVIORAL: Oral Hygiene instruction|PROCEDURE: Dental Cleaning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial to Evaluate Single- and Double- Freeze Cryotherapy in the Prevention of Cervical Neoplasia
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: Cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Effectiveness of Asoprisnil in the Treatment of Uterine Fibroids
Status: COMPLETED
Conditions: Leiomyoma|Menorrhagia|Metrorrhagia
Interventions: DRUG: Asoprisnil|DRUG: Asoprisnil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Wraparound for High-risk Families With Substance Use Disorders: Examining Family, Child, and Parent Outcomes
Status: RECRUITING
Conditions: Substance-Related Disorders|Depression|Stress Disorders, Post-Traumatic|Child Abuse|Child Neglect
Interventions: BEHAVIORAL: Wraparound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing SB2 to Remicade® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Remicade (infliximab)|DRUG: SB2 (proposed biosimilar to infliximab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures
Status: UNKNOWN
Conditions: Fractures
Interventions: DRUG: Teriparatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study for Ureter Visualization, Using ASP5354 in Subjects Undergoing Laparoscopic/Minimally Invasive Colorectal Surgery
Status: COMPLETED
Conditions: Laparoscopic/Minimally Invasive Colorectal Surgery
Interventions: DRUG: Pudexacianinium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: SloMo2: Implementation, Effectiveness, and Cost-effectiveness Study
Status: NOT_YET_RECRUITING
Conditions: Schizophrenia Spectrum and Other Psychotic Disorders|Affective Psychoses
Interventions: OTHER: SloMo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Belated Pulmonary Complications Occurring in Children Treated With Allogeneic Hematopoietic Stem Cells.
Status: COMPLETED
Conditions: Bone Marrow Transplant Infection|Bronchiolitis Obliterans|Chronic Respiratory Insufficiency|Organizing Pneumonia|Pulmonary Cytolytic Thrombi
Interventions: OTHER: late pulmonary complications occurring in children treated with allogeneic hematopoietic stem cells.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Blood Oxygen Level Dependent Magnetic Resonance Imaging (BOLD MRI) and Fluorothymidine Positron Emission Tomography (FLT PET) in Patients With Locally Advanced Breast Cancer Undergoing Neoadjuvant Chemotherapy
Status: COMPLETED
Conditions: Locally Advanced Breast Cancer (LABC)
Interventions: PROCEDURE: FLT PET and BOLD MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Study of Clozapine Augmented by Atomoxetine Versus Clozapine Augmented by Placebo in Patients With Chronic Resistant Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Clozapine augmented with atomoxetine up to 40 mg or placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Fecal Microbiota Transplantation Engraftment in IBS
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: PROCEDURE: fecal microbiota transplantation|DRUG: placebo fecal microbiota transplantation|PROCEDURE: FMT with antibiotic pre-treatment (v1)|PROCEDURE: FMT with antibiotic pre-treatment (v2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: U Shaped Toothbrush in Removing Plaque in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Plaque
Interventions: OTHER: Traditional toothbrush group|OTHER: U shaped toothbrush group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Injection of Botulinum Toxin for Thumb Carpometacarpal Arthritis
Status: RECRUITING
Conditions: Carpometacarpal Sprain|Thumb Sprain|Clostridium; Botulinum
Interventions: DRUG: Botulinum toxin|DRUG: Standard-of-care corticosteroid injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Interest of Concentrations in Meconium of Buprenorphine and Methadone as a Prognostic Factor of NAS Outcome
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome
Interventions: PROCEDURE: Concentrations in Meconium of Buprenorphine and Methadone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PhII Neo-Adjuvant Letrozole & Lapatinib in Pts w/HER2+ & Hormone Receptor+ Operable Breast CA SPORE
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: lapatinib ditosylate|DRUG: letrozole|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Pulmonary Nodule With Imaging and Biomarkers
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DEVICE: Olympus Ultrathin Bronchofibervideoscope (XP260F)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase 2 Study Assessing Efficacy and Safety of Crizotinib in Patients Harboring an Alteration on ALK, MET or ROS1
Status: COMPLETED
Conditions: Hematologic Cancers|Solid Tumors|Metastatic Cancer
Interventions: DRUG: Crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: AV078|DRUG: Placebo|DRUG: Itraconazole|DRUG: Midazolam|DRUG: Fexofenadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Progestogen Supplementation in the Prevention of Recurrent Uterine Contraction in Preterm Labor
Status: COMPLETED
Conditions: Preterm Labor
Interventions: DRUG: dydrogesterone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Addressing Sleep Problems in Older Adults
Status: WITHDRAWN
Conditions: Sleep
Interventions: DIETARY_SUPPLEMENT: Fruit/Honey drink|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inotuzumab Ozogamicin and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia
Status: WITHDRAWN
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation Recipient|Blasts 5 Percent or More of Bone Marrow Nucleated Cells|Blasts 5 Percent or More of Peripheral Blood White Cells|CD22 Positive|Lymphoblasts 20 Percent or More of Bone Marrow Nucleated Cells|Lymphoblasts 20 Percent or More of Peripheral Blood White Cells|Recurrent B Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: Inotuzumab Ozogamicin|OTHER: Quality-of-Life Assessment|DRUG: Vincristine Sulfate Liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Renal Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time-Of-Flight (TOF)
Status: TERMINATED
Conditions: Renal Disease
Interventions: DRUG: Dotarem|OTHER: Time of Flight
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Evaluation of Nabilone as Adjunctive Therapy to Gabapentin for the Management of Neuropathic Pain in Multiple Sclerosis
Status: COMPLETED
Conditions: Neuropathic Pain|Multiple Sclerosis
Interventions: DRUG: nabilone|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Educational Group Intervention on the Consumption of Fruit and Vegetables
Status: UNKNOWN
Conditions: Inclusion Criteria:|Adult|No Pregnancy|No Lactation|No Morbidity
Interventions: BEHAVIORAL: nutritional education group action
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Arthroscopic Clinical Study of Double Bundle Anatomical Reconstruction of Medial Patellofemoral Ligament
Status: RECRUITING
Conditions: Recurrent Patellar Dislocation
Interventions: OTHER: Patients with patellar dislocation undergo patellar femoral medial reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Telerehabilitation on Scleroderma
Status: UNKNOWN
Conditions: Scleroderma|Scleroderma, Systemic|Scleroderma Associated Digital Ulcer|Hand Rheumatism|Physiotherapy|Rehabilitation
Interventions: OTHER: Hand Therapy via Telerehabilitation|OTHER: Hand Therapy by Physiotherapist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT
Status: TERMINATED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Travoprost/Brinzolamide|DRUG: Cosopt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety, Tolerability, and Pharmacokinetics (PK) of HKI-357 Administered Orally to Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: HKI-357
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Bending Angles for Nasotracheal Intubation With a Malleable Vedio Stylet
Status: COMPLETED
Conditions: Intubation;Difficult
Interventions: DEVICE: bending angle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Nonalcoholic Steatohepatitis
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Lisinopril|PROCEDURE: Liver Ultrasonographic Elastography|PROCEDURE: Magnetic Resonance Elastography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Proton Density Fat Fraction|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Lu-PSMA and Stereotactic Radiotherapy Versus Radiotherapy Alone for Prostate Cancer (LUST)
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: [177Lu]Lu-PSMA I&T|RADIATION: Stereotactic Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of ATG for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT
Status: COMPLETED
Conditions: aGVHD
Interventions: DRUG: ATG|DRUG: CsA|DRUG: mycophenolate mofetil|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preauthorization Versus Prospective Audit in Antimicrobial Stewardship Program
Status: UNKNOWN
Conditions: Bacterial Infections
Interventions: OTHER: Prospective audit strategy of antimicrobial stewardship|OTHER: preauthorization strategy of antimicrobial stewardship
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Sleep Bruxism and (Peri-)Implant Complications
Status: COMPLETED
Conditions: Dental Implant Complications|Sleep Bruxism
Interventions: DEVICE: Electromyographic recording of temporalis muscle activity during sleep|RADIATION: Vertical bitewing radiograph|OTHER: Collection of biofilm sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SHADES Mechanistic Trial
Status: ENROLLING_BY_INVITATION
Conditions: Insomnia|Insomnia Chronic|Insomnia, Primary|Sleep Disturbance|Sleep Disorder|Cardiovascular Diseases|Heart Diseases|Coronary Artery Disease|Stroke|Autonomic Dysfunction|Systemic Inflammatory Response|Metabolic Disease
Interventions: BEHAVIORAL: Sleep Healthy Using The Internet (SHUTi)|BEHAVIORAL: Telephonic CBT-I|BEHAVIORAL: Face-to-Face CBT-I|OTHER: Active Control: Sleep Education/Hygiene, Symptom Monitoring, and Usual Primary Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Bendamustine, Velcade and Dexamethasone in the Treatment of Elderly Patients With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bendamustine, Velcade and Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Muscle Energy Technique Versus Maitland Mobilization on Shoulder Pain and Disability
Status: COMPLETED
Conditions: Neck Cancer|Mobility Limitation|Pain Syndrome|Shoulder Pain|Surgery
Interventions: OTHER: Muscle energy technique|OTHER: Maitland mobilization|OTHER: Traditional shoulder exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interleukin-6 Inhibitors and Drug-drug Interactions in Patients With Rheumatoid Arthritis
Status: TERMINATED
Conditions: Arthritis, Rheumatoid|Interaction
Interventions: DRUG: Tocilizumab|DRUG: Sarilumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Single and Multiple Ascending Dose Study of ADX-914 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Safety Issues
Interventions: DRUG: ADX-914|DRUG: Placebo|DRUG: ADX-914|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent
Status: NOT_YET_RECRUITING
Conditions: Hypovolemic Shock
Interventions: DRUG: Normal Saline|DRUG: Centhaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial in Chinese Patients of Elapsed/Metastatic/Unresectable Alveolar Soft Part Sarcoma(GB226)
Status: UNKNOWN
Conditions: Alveolar Soft Part Sarcoma
Interventions: BIOLOGICAL: GB226
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DIAGNOSTIC_TEST: Transthoracic Echocardiography|DIAGNOSTIC_TEST: Arterial blood pressure|DIAGNOSTIC_TEST: Submaximal Exercise
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Response Study of Dexmedetomidine in Orthopaedic Spine Surgery Patients
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Dexmedetomidine|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: the Safety and Effectiveness of Protein Supplements on Cancer Patients With Nutritional Risk and Malnutrition
Status: NOT_YET_RECRUITING
Conditions: Cancer|Malnutrition
Interventions: DIETARY_SUPPLEMENT: protein supplement|BEHAVIORAL: nutrition counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Mouthwash Formulation CTP/BNZ With Mucus Adhesive Polymer
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cetylpyridinium Chloride 0.05% + Benzydamine HCl 0.15% + mucus adhesive polymer|DRUG: Cetylpyridinium Chloride 0.05% + Benzydamine HCl 0.15%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: KISS Study: Kinase Inhibition With Sprycel Start up
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Dasatinib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Metformin|DRUG: Dapagliflozin 10 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of SBRT in Oligo-metastatic/Persistent/Recurrent Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms|Recurrent Ovarian Carcinoma|Oligometastatic Disease
Interventions: RADIATION: Stereotactic body radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1911GCCC: Galeterone or Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Advanced Pancreatic Cancer
Interventions: DRUG: galeterone|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placement of Covered Stents to Treat Hemodialysis Access Stenoses in the Cephalic Arch and Central Veins
Status: UNKNOWN
Conditions: Hemodialysis
Interventions: OTHER: PTA alone without use of the GORE VIABAHN|DEVICE: GORE VIABAHN® Endoprosthesis with Heparin Bioactive Surface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of 5% Lidocaine Patches in the Pain Control of Hepatocellular Carcinoma Patients Receiving Radiofrequency Ablation
Status: COMPLETED
Conditions: Liver Cancer|Post Ablation Syndrome
Interventions: DRUG: The skin lidocaine patch.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 In-vivo Biliary Study of KSP/QRH Heptapeptide Dimer
Status: TERMINATED
Conditions: Cholangiocarcinoma
Interventions: DRUG: KSP/QRH dimer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Combined Intravitreal Fasudil and Bevacizumab for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Intravitreal injection of bevacizumab (Avastin)|DRUG: Intravitreal injection of fasudil and bevacizumab (Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 PK Study to Assess Safety, PK, Tolerability of HM15912 in Subjects With Renal Impairment and Normal Renal Function
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: HM15912
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HN-BIO: A Study of Head and Neck MRI and Tumor Microenvironment Biomarkers
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: OTHER: fMRI|OTHER: Oral Pimonidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Care of Patients Undergoing Pancreaticoduodenectomy
Status: RECRUITING
Conditions: Pancreatic Diseases|Pancreas Cancer
Interventions: PROCEDURE: Analgesia via epidural catheter|PROCEDURE: Analgesia via wound catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of CoFactor Formulations and Leucovorin Administered Intravenously in Healthy, Adult Subjects.
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: CoFactor|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Local Application of Warm Air in Patients With Common Cold (HELI Study)
Status: COMPLETED
Conditions: Common Cold
Interventions: PROCEDURE: inhalation of warm air in a Finnish sauna|PROCEDURE: inhalation of ambient air in a Finnish sauna
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Menopause Hormonal Therapy and Selective Serotonin Reuptake Inhibitor on Cognition, Sexual Function and Quality of Life
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Hormone replacement therapy|DRUG: Selective serotonin reuptake inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rt-PA Infusion Versus Catheter Exchange for Dialysis Catheter Malfunction Due to Fibrin Sheath
Status: TERMINATED
Conditions: Dialysis Catheter Fibrin Sheath|Clotted Dialysis Catheter|Catheter Malfunction
Interventions: DRUG: TPA Infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs
Status: COMPLETED
Conditions: Dyspnea|Hypercapnia|Respiratory Insufficiency
Interventions: DEVICE: Control Cannula - Prosoft Cannula - Unicorn Cannula|DEVICE: Control Cannula - Unicorn Cannula - Prosoft Cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Daily Adaptive Radiotherapy to Better Organ-at-Risk Doses in Head and Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer
Interventions: RADIATION: Intensity modulated radiation therapy (IMRT) with or without chemotherapy|DRUG: cisplatin, cetuximab, or carboplatin-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Yiqi Huoxue Huatan Granule for Reducing Mortality in COPD With Chronic Respiratory Failure
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Chronic Respiratory Failure
Interventions: DRUG: Yiqi Huoxue Huatan granule|DRUG: Placebo Yiqi Huoxue Huatan granule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RC48-ADC Combination Therapies as First-line Treatment in Advanced Metastatic Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: RC48-ADC|DRUG: Trastuzumab Injection|DRUG: Toripalimab|DRUG: Oxaliplatin injection|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Standard of Care +/- 177Lu-PSMA-617 In de Novo mHSPC Patients With Poor PSA Response (PEACE6-Poor Responders)
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer Metastatic
Interventions: DRUG: 177Lu-PMSA-617|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Triamcinolone Treatment of Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Chronic Pain|Carpal Tunnel Syndrome
Interventions: DRUG: Dexmedetomidine|DRUG: Triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Bevacizumab and Pegylated Liposomal Doxorubicin in Patients With Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Bevacizumab|DRUG: pegylated liposomal doxorubicin (PLD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Moxetumomab Pasudotox in Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia (ALL)
Status: TERMINATED
Conditions: Leukemia
Interventions: DRUG: Moxetumomab Pasudotox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects
Status: COMPLETED
Conditions: Other Conditions That May Be A Focus of Clinical Attention
Interventions: DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing Cholangitis (PSC)
Status: TERMINATED
Conditions: Primary Sclerosing Cholangitis
Interventions: DRUG: DUR-928
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Reduction for Early Rheumatoid Arthritis Patients With Low Disease Activity
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Sulphasalazine + Hydroxychloroquine OR Prednisolone|BIOLOGICAL: Cimzia|BIOLOGICAL: Orencia|BIOLOGICAL: RoActemra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Recombinant HIV Vaccines for HIV/AIDS
Status: UNKNOWN
Conditions: Acquired Immunodeficiency Syndrome
Interventions: BIOLOGICAL: Saline Solution|BIOLOGICAL: D-GPEi|BIOLOGICAL: M-GPE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: US-guided Ilioinguinal Blocks Versus Local Infiltration
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Ilioinguinal block|PROCEDURE: Local infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Gut Microbiome in FLT3-ITD+ AML Undergoing Allo-HSCT With Or Without Sorafenib Maintenance After Allo-HSCT
Status: RECRUITING
Conditions: Acute Myeloid Leukemia With FLT3/ITD Mutation|Allogeneic Hematopoietic Stem Cell Transplantation
Interventions: DRUG: Sorafenib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intravitreal Aflibercept in Neovascular AMD With Limited Response to Ranibizumab
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration
Interventions: DRUG: aflibercept 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Term Effect of Kinesiotaping In Patients With Shoulder Impingement Syndrome
Status: COMPLETED
Conditions: Kinesiotape|Exercise|Ultrasound
Interventions: OTHER: Cold Application|OTHER: Kinesiotaping Application|OTHER: Exercise treatment|OTHER: Sham Kinesio taping application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise-induced Muscle Damage is Reduced in Resistance Trained Athletes by Branch Chain Amino Acids
Status: COMPLETED
Conditions: Exercise-induced Muscle Damage
Interventions: DIETARY_SUPPLEMENT: Branch Chain Amino Acid (BCAA)|DIETARY_SUPPLEMENT: Placebo - asparmate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Bimekizumab in the Treatment of Subjects With Active Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Bimekizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2, Safety & Microbiology Study of C16G2 in Multiple Oral Gel &/or Mouth Rinse Doses to Healthy Adults
Status: COMPLETED
Conditions: Dental Caries
Interventions: DRUG: C16G2 Rinse|DRUG: Placebo|DRUG: C16G2 Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety of Transarterial Chemoembolization (TACE) in the Setting of an Elevated Bilirubin
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Bilirubinemia
Interventions: COMBINATION_PRODUCT: Transarterial chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Paclitaxel in Elderly Women With Newly Diagnosed Ovarian, Peritoneal, or Fallopian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Primary Peritoneal Carcinoma|Fallopian Tube Cancer|Mixed Tumor, Mesodermal
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of 5-fraction Stereotactic Partial Breast Irradiation and Whole Breast Irradiation on Cosmetic Outcome and Patient-reported Outcomes in Early-stage Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: RADIATION: Partial breast irradiation|RADIATION: Whole breast irradiation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Immunogenicity and Safety of the 2006-2007 Influenza Vaccine
Status: COMPLETED
Conditions: Influenza|Orthomyxoviridae Infections
Interventions: BIOLOGICAL: Inactivated influenza vaccine (split virion)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety and Tolerability of NPSP558, for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study in Hungary
Status: COMPLETED
Conditions: Hypoparathyroidism
Interventions: DRUG: NPSP558
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
Status: COMPLETED
Conditions: Aging
Interventions: BEHAVIORAL: Resistance Exercise|DIETARY_SUPPLEMENT: 14 g Whey protein|DIETARY_SUPPLEMENT: 6.6 g Whey protein + 1.25 g leucine|DIETARY_SUPPLEMENT: 4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides|DIETARY_SUPPLEMENT: 6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline|OTHER: Water control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability and Efficacy Study With a Fixed-Dose Combination (FDC) Ketoprofen Plus Omeprazole
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: FDC KETOPROFEN+OMEPRAZOLE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAFLD Among Patients With Type 2 Diabetes and CKD
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Chronic Kidney Diseases|Type2 Diabetes
Interventions: DIAGNOSTIC_TEST: Magnetic resonance (MR) spectroscopy of the liver|DIAGNOSTIC_TEST: Fibroscan|DEVICE: Continuous glucose monitoring (CGM) for four days.|RADIATION: Dual Energy X-ray Absorptiometry (DEXA) scan|BIOLOGICAL: Blood samples|OTHER: Clinical and demographic data
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Immunogenicity and Safety of CSL's 2009 / 2010 Formulation of Enzira® Vaccine in Healthy Volunteers
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Inactivated Influenza Vaccine (2009 / 2010 formulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of a Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) Virus-like Particle (VLP) Vaccine in Healthy Adults
Status: COMPLETED
Conditions: Covid19
Interventions: BIOLOGICAL: SARS-CoV-2 VLP Vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Diode Laser on the Reversal of Inferior Alveolar Nerve Block Anesthesia in Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia, Local
Interventions: OTHER: Inferior Alveolar Nerve Block administration with laser irradiation|OTHER: Inferior Alveolar Nerve Block administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER