pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Intracoronary Stenting and Antithrombotic Regimen: Lesion Platelet Adhesion as Selective Target of Endovenous Revacept
Status: COMPLETED
Conditions: Stable Coronary Artery Disease
Interventions: DRUG: Revacept 80 mg|DRUG: Revacept 160 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral Pregabalin on Hyperalgesia and Post-operative Pain in Patients Undergoing Nephrectomy Surgery: Sex Differential Study
Status: WITHDRAWN
Conditions: Living Kidney Donors Undergoing VAMS-nephrectomy
Interventions: DRUG: Pregabalin_male|DRUG: Pregabalin_female|DRUG: Placebo_Men|DRUG: Placebo_Women
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial for Evaluating the Efficacy and Safety of BCG for Therapeutic Use in the Prevention of Postoperative Recurrence of Medium/High-risk Non-muscle Invasive Bladder Cancer (NMIBC)
Status: RECRUITING
Conditions: Non-Muscle Invasive Bladder Cancer
Interventions: DRUG: BCG for Therapeutic Use|DRUG: BCG for Therapeutic Use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults
Status: COMPLETED
Conditions: Opioid Overdose
Interventions: COMBINATION_PRODUCT: 16 mg naloxone AP003|COMBINATION_PRODUCT: 8 mg naloxone NARCAN Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Depression
Interventions: BEHAVIORAL: Problem Solving-Rx Adherence (PSA)|BEHAVIORAL: PID-C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monell USDA Taste Test Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Diet
Interventions: OTHER: Diet composition 1|OTHER: Diet composition 2|OTHER: Diet composition 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis
Status: UNKNOWN
Conditions: Liver Cirrhosis|Carcinoma, Hepatocellular|Splenomegaly|Laparotomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analgesia Nociception Index in Orthognathic Surgery
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DEVICE: Analgesia/Nociception Index (ANI) monitoring|DEVICE: Standard monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of BG2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids.
Status: RECRUITING
Conditions: Uterine Fibroids|Heavy Menstrual Bleeding
Interventions: DRUG: BG2109|DRUG: Placebo for BG2109|DRUG: Placebo for add-back therapy|DRUG: Add-back therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RO6885247 in Adult and Pediatric Patients With Spinal Muscular Atrophy (MOONFISH)
Status: TERMINATED
Conditions: Muscular Atrophy, Spinal
Interventions: DRUG: RO6885247|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors of Intravenous Ketamine Response in TRD
Status: RECRUITING
Conditions: Treatment Resistant Depression|Major Depressive Disorder|Bipolar Disorder
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Δ9-THC for Postsurgical Pain
Status: UNKNOWN
Conditions: Pain
Interventions: DRUG: Namisol|DRUG: Diazepam/placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Lung Lesions by Endobronchial Ultrasound With an Alternative Guide Sheath
Status: COMPLETED
Conditions: Pulmonary Neoplasms|Solitary Pulmonary Nodules
Interventions: DEVICE: guide sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Mobile App Based Cognitive Dissonance Intervention for Smoking Cessation
Status: RECRUITING
Conditions: Tobacco Use
Interventions: BEHAVIORAL: CoQuit App - Cognitive Dissonance Based Smoking Cessation + Smoking Cessation Tips|BEHAVIORAL: Tips for Smoking Cessation App
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Zinc Supplementation in Patients With β-Thalassemia Major Complicated With Diabetes Mellitus
Status: COMPLETED
Conditions: Beta-thalassemia Major Complicated With Diabetes
Interventions: DRUG: Zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of LDL Apheresis System on the Expression of Genes Involved in Lipoprotein Metabolism and Inflammation in Homozygotes for Familial Hypercholesterolemia
Status: COMPLETED
Conditions: Familial Hypercholesterolemia
Interventions: OTHER: Pre-lipid apheresis|OTHER: Post-lipid apheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cangrelor vs. Ticagrelor for Early Platelet Inhibition in STEMI
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Myocardial Infarction|STEMI - ST Elevation Myocardial Infarction
Interventions: DRUG: Ticagrelor|DRUG: Cangrelor Tetrasodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease
Status: UNKNOWN
Conditions: Cushing's Disease|Corticotrophin Adenoma
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study to Learn More About Treatment With Regorafenib in People With Advanced Gastrointestinal Stromal Tumors in the United States
Status: COMPLETED
Conditions: Advanced Gastrointestinal Stromal Tumor
Interventions: DRUG: Regorafenib (Stivarga, BAY73-4506)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Spinal Nalbuphine for Analgesia in Total Hip Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Total Hip Arthroplasty|Analgesia
Interventions: DRUG: Levobupivacaine|DRUG: Levobupivacaine plus nalbuphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antibiotic Nephrotoxicity in Adult Patients With Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: DRUG: Amikacin|DRUG: Tobramycin|DRUG: Colomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of Imiquimod 5% Cream Applied 3x Per Week for 8 or 12 Weeks in Low Risk Nodular Basal Cell Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Basal Cell
Interventions: DRUG: Imiquimod
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Study to Compare the Treatment of Angioplasty and Stents in SFA Occlusions.
Status: TERMINATED
Conditions: Arterial Occlusive Diseases
Interventions: DEVICE: stent|DEVICE: angioplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long-Term Safety Follow-Up Study for Patients Treat With WU-CART-007
Status: ENROLLING_BY_INVITATION
Conditions: T-cell Acute Lymphoblastic Leukemia|T-cell Lymphoblastic Lymphoma
Interventions: GENETIC: Genetic: WU-CART-007
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Assess the Safety, Tolerability, and Pharmacokinetics of AZD7624 in Healthy Volunteers and COPD Patients
Status: COMPLETED
Conditions: COPD|Healthy Subjects
Interventions: DRUG: AZD7624|DRUG: Placebo to match
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Device Closure of Patent Foramen Ovale in Elderly Patients With Crytogenic Stoke/TCI
Status: TERMINATED
Conditions: Patent Foramen Ovale|PFO|Stroke|TIA
Interventions: DEVICE: Percutaneous device closure of patent foramen ovale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Enterra Therapy Clinical Study (Gastric Stimulation for Gastroparesis)
Status: TERMINATED
Conditions: Gastroparesis
Interventions: DEVICE: Enterra Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tazemetostat Expanded Access Program for Adults With Solid Tumors
Status: NO_LONGER_AVAILABLE
Conditions: Epithelioid Sarcoma (Ex-US Only)|Spindle Cell Sarcoma|Sinonasal Carcinoma|Small Cell Carcinoma of the Ovary Hypercalcemic Type|Thoracic Sarcoma|Poorly Differentiated Chordoma|ATRT|Malignant Rhabdoid Tumor of Kidney|Malignant Rhabdoid Tumor of Ovary|Malignant Rhabdoid Tumor|Myxoid Spindle Cell Sarcoma|Epithelioid Malignant Peripheral Nerve Sheath Tumor|Chondrosarcoma|Renal Cell Carcinoma|Myoepithelial Carcinoma|Synovial Sarcoma|Renal Medullary Carcinoma|Malignant Mesothelioma|Desmoplastic Small Round Cell Tumor (DSRCT)|Intramedullary Spinal Cord Schwannomatosis
Interventions: DRUG: Tazemetostat
Study Type: EXPANDED_ACCESS
Clinical trial: Comparison Between Intraperitoneal Versus Intramuscular Neostigmine on Pattern of Postoperative GIT Motility in Patients Undergoing Laparoscopic Cholecystectomy
Status: UNKNOWN
Conditions: Pattern of GIT Motility
Interventions: DRUG: Neostigmine|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Maternal Vitamin D3 Supplementation on Iron Status During Pregnancy and Early Infancy
Status: COMPLETED
Conditions: Pregnancy
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Vitamin D3 (cholecalciferol)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ponesimod dose range (2 - 20 mg)|DRUG: Placebo Propranolol|DRUG: Propranolol 80 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Infliximab and Basiliximab for Treatment of Steroid Refractory Acute Graft Versus Host Disease
Status: TERMINATED
Conditions: Graft Versus Host Disease|Steroid Refractory GVHD|Acute GVH Disease
Interventions: DRUG: Infliximab and Basiliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nepafenac Opthalmic Suspension 0.1% Compared to Acular LS for Treatment of Inflammation After Cataract Surgery
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Nepafenac Ophthalmic Suspension, 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Patients With Moderate to Severe Atopic Dermatitis Treated With Chinese Herbal Medicine
Status: UNKNOWN
Conditions: Atopic Dermatitis
Interventions: DRUG: Xiao-Xian-Gui-Fu-Tang
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Postoperative Urinary Retention With Treatment of Tamsulosin 5 Days Prior to Lower Limb Arthroplasty
Status: RECRUITING
Conditions: Urinary Retention Postoperative|Arthropathy of Knee|Arthropathy of Hip
Interventions: DRUG: Tamsulosin|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
Status: COMPLETED
Conditions: Potentially Malignant Lesions|Oral Lichen Planus|Leukoplakia, Oral
Interventions: DIAGNOSTIC_TEST: Real-time Polymerase Chain Reaction technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The D-BIICEP Study
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: RADIATION: DEXA|RADIATION: pQCT|OTHER: Lifestyle Questionnaire|OTHER: Aerobic Fitness|OTHER: Muscular Strength|BIOLOGICAL: Blood draw and finger prick test|OTHER: Muscular Power
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cognitive Behavioural Therapy- Social Functioning In Adolescence With Recent Onset Schizophrenia
Status: COMPLETED
Conditions: Psychotic Disorders
Interventions: BEHAVIORAL: CBT-SA|BEHAVIORAL: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Immersive Communication Training on Recommending Immunizations
Status: COMPLETED
Conditions: Human Papilloma Virus
Interventions: BEHAVIORAL: Virtual Immersive Communication Training on Recommending Immunizations (VICTORI)|BEHAVIORAL: HPV Same Way Same Day App
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions
Status: NOT_YET_RECRUITING
Conditions: CBD Pharmacokinetics|Healthy Participants
Interventions: DRUG: Cannabidiol (CBD) Powder|DRUG: Cannabidiol 100 MG/ML [Epidiolex]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Healthy Futures Project: A Community Based Obesity Prevention Program
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Switch active lifestyles brought to you by MediaWise|BEHAVIORAL: Switch active lifestyles from MediaWise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Selective sPlenic flExure Mobilization for Low colorEctal Anastomosis After D3 lYmph Node Dissection (Speedy Trial)
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: Paraaortic lymph node dissection, IMA high ligation, TME, routine splenic flexure mobilization|PROCEDURE: Paraaortic lymph node dissection, IMA low ligation, TME, selective splenic flexure mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of CROW 3d Printed Sole on Charcot Foot Ulcer
Status: COMPLETED
Conditions: Charcot Joint of Foot
Interventions: DEVICE: Charcot Restraint Orthotic Walker 3d printed sole|DEVICE: Generic Charcot Restraint orthotic walker
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics and Insulin Resistance in Obese Asthmatics
Status: ENROLLING_BY_INVITATION
Conditions: Asthma|Obesity|Insulin Resistance
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: R-Verapamil for the Prophylaxis of Episodic Cluster Headache
Status: TERMINATED
Conditions: Episodic Cluster Headache
Interventions: DRUG: R-verapamil 75 mg tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)
Status: COMPLETED
Conditions: Treatment Resistant Depression
Interventions: DRUG: Ketamine|DRUG: Ketamine|DRUG: Ketamine|DRUG: Ketamine|DRUG: Placebo Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS)
Status: WITHDRAWN
Conditions: Sturge Weber Syndrome
Interventions: DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD
Status: ACTIVE_NOT_RECRUITING
Conditions: Amyotrophic Lateral Sclerosis|Frontotemporal Dementia
Interventions: DRUG: TPN-101, 400 mg/day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Stage 2 Cognitive-behavioral Trial: Reduce Alcohol First in Kenya Intervention
Status: COMPLETED
Conditions: Hazardous Drinking|Binge Drinking|HIV-infected
Interventions: BEHAVIORAL: cognitive behavioral group therapy|BEHAVIORAL: health education group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Bapineuzumab 0.5 mg/kg|DRUG: Placebo Control|DRUG: Bapineuzumab 1.0 m/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children With Cancer
Status: COMPLETED
Conditions: Siblings|Childhood Cancer|Pediatric Cancer|Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: SibACCESS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Physiotherapy for Urinary Incontinence in Women With a Puborectalis Avulsion
Status: COMPLETED
Conditions: Urinary Incontinence|Postpartum|Pelvic Floor; Perineal Rupture, Obstetric|Physiotherapy
Interventions: PROCEDURE: Multimodal physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Fecal Immunochemical Test Using Digital Rectal Exam
Status: TERMINATED
Conditions: Fecal Immunochemical Test
Interventions: DEVICE: FIT-SOC|DEVICE: FIT-DRE
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis
Status: COMPLETED
Conditions: Ascites|Cirrhosis
Interventions: DRUG: Albumin|DRUG: Intravenous Saline Infusion (Albumin placebo)|DRUG: Midodrine|DRUG: Oral tablet (Midodrine placebo)|DRUG: Octreotide LAR|DRUG: Saline injection (Octreotide LAR placebo)|PROCEDURE: Large Volume Paracentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CMAB009 to Treat KRAS Wild Type Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: CMAB009 plus Irinotecan|DRUG: Irinotecan-only and sequential-CMAB009
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of High Velocity Nasal Insufflation
Status: UNKNOWN
Conditions: Acute Respiratory Failure|Diaphragmatic Function|Esophageal Pressure
Interventions: DEVICE: Physiological assesment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Immunohistochemical Staining for the Prediction of Wilms Tumour Progression and Recurrence
Status: UNKNOWN
Conditions: Wilms Tumor|Relapse|Death
Interventions: DIAGNOSTIC_TEST: P53, Ki67 and Cyclin A IHC.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
Status: TERMINATED
Conditions: Rheumatoid Arthritis|Osteoarthritis|Post-traumatic Arthritis|Avascular Necrosis|Traumatic Femoral Fractures|Congenital Hip Dysplasia
Interventions: DEVICE: DePuy Proxima™ Hip
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety, Preference and Response Duration of Clobex® Spray and Taclonex® Ointment in Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: Clobetasol Propionate, 0.05%|DRUG: Calcipotriene and betamethasone dipropionate ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sodium Oxybate in Idiopathic Hypersomnia
Status: COMPLETED
Conditions: Idiopathic Hypersomnia
Interventions: DRUG: Sodium Oxybate Oral Solution 500 MG/ML|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Safety and Efficacy of Apitox Add-on Therapy for Improving Disability and Quality of Life in MS Patients
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Apitox - pure honeybee toxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: E-aid Cognitive Behavior Therapy for Insomnia to Prevent Transition From Acute Insomnia to Chronic Insomnia in China
Status: COMPLETED
Conditions: Insomnia
Interventions: BEHAVIORAL: eCBTI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics (PK) of Tipranavir/Ritonavir, Ribavirin, Pegylated Interferon (Peg INF) in Hepatitis C (HCV) Subjects With Mild Hepatic Impairment and in HCV, Hepatitis B (HBV), Hepatitis D Infected Subjects or Alcoholic Cirrhosis With Moderate Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Insufficiency
Interventions: DRUG: Tipranavir|DRUG: Ritonavir|DRUG: Pegylated interferon|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of NUV001 Supplementation in Patients Suffering From Sickle Cell Disease (SCD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease
Interventions: DIETARY_SUPPLEMENT: NUV001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Protective Effect of JOINS on Cartilage in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: JOINS 200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Laughter Yoga Practiced Before Simulation Training
Status: COMPLETED
Conditions: Laughter|State Anxiety|Stress|Self Confidence|Satisfaction, Personal
Interventions: OTHER: Laughter Yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Tackling Intrusive Traumatic Memories After Childbirth
Status: RECRUITING
Conditions: Posttraumatic Stress Disorder|Intrusive Traumatic Memories
Interventions: BEHAVIORAL: A single-session behavioral intervention composed of a brief evocation of the childbirth memory followed by a Tetris gameplay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Short Course Radiation Therapy With Proton or Photon Beam Capecitabine and Hydroxychloroquine for Resectable Pancreatic Cancer
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Capecitabine|DRUG: Hydroxychloroquine|RADIATION: Proton or Photon Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Intervention Strategies for Addressing Obesity and Binge Eating
Status: COMPLETED
Conditions: Obesity|Binge Eating
Interventions: BEHAVIORAL: Behavioral weight loss|BEHAVIORAL: Intervention component: Decrease overvaluation of weight and shape|BEHAVIORAL: Intervention component: Decrease unhealthy weight control practices|BEHAVIORAL: Intervention component: Decrease negative affect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid Effect on Digit Function Following Primary Repair of Traumatic Digit Flexor Tendon Injuries
Status: UNKNOWN
Conditions: Tendon Injury - Hand
Interventions: DRUG: Tranexamic acid injection|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Ependymoma|Recurrent Ewing Sarcoma|Recurrent Hepatoblastoma|Recurrent Langerhans Cell Histiocytosis|Recurrent Malignant Germ Cell Tumor|Recurrent Malignant Glioma|Recurrent Malignant Solid Neoplasm|Recurrent Medulloblastoma|Recurrent Neuroblastoma|Recurrent Non-Hodgkin Lymphoma|Recurrent Osteosarcoma|Recurrent Peripheral Primitive Neuroectodermal Tumor|Recurrent Rhabdoid Tumor|Recurrent Rhabdomyosarcoma|Recurrent Soft Tissue Sarcoma|Recurrent WHO Grade 2 Glioma|Refractory Ependymoma|Refractory Ewing Sarcoma|Refractory Hepatoblastoma|Refractory Langerhans Cell Histiocytosis|Refractory Malignant Germ Cell Tumor|Refractory Malignant Glioma|Refractory Malignant Solid Neoplasm|Refractory Medulloblastoma|Refractory Neuroblastoma|Refractory Non-Hodgkin Lymphoma|Refractory Osteosarcoma|Refractory Peripheral Primitive Neuroectodermal Tumor|Refractory Rhabdoid Tumor|Refractory Rhabdomyosarcoma|Refractory Soft Tissue Sarcoma|Refractory WHO Grade 2 Glioma|Wilms Tumor
Interventions: DRUG: Ivosidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)
Status: TERMINATED
Conditions: Ovulation Induction
Interventions: DRUG: corifollitropin alfa|BIOLOGICAL: recombinant Follicle Stimulating Hormone (recFSH)|BIOLOGICAL: human Chorion Gonadotropin (hCG)|BIOLOGICAL: hCG Bolus injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Community Based Prevention of Rotavirus Gastroenteritis by a Functional Food Supplement
Status: COMPLETED
Conditions: Rotavirus Gastroenteritis
Interventions: DIETARY_SUPPLEMENT: Anti-rotavirus protein|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fine Needle Biopsy of Solid Pancreatic Mass Lesions
Status: UNKNOWN
Conditions: Pancreatic Neoplasms
Interventions: DIAGNOSTIC_TEST: Solid pancreatic mass lesion biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Dose-response to Bronchodilator and Dose-finding in Child 2.5 to 6 Years - Study Golden
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: salbutamol|DRUG: Salbutamol - dose2|DRUG: Salbutamol -dose3|DRUG: salbutamol -dose4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Early Alzheimer's Disease
Interventions: DRUG: Lecanemab|DRUG: Placebo|DRUG: Lecanemab|DRUG: Lecanemab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Enoximone in Acute Exacerbation COPD
Status: TERMINATED
Conditions: COPD Exacerbation|Enoximone|Phosphodiesterase Inhibitor
Interventions: DRUG: Enoximone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infliximab as Induction Therapy in Early Rheumatoid Arthritis (IDEA)
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Infliximab|DRUG: Methylprednisolone|DRUG: Methotrexate|DIETARY_SUPPLEMENT: Folic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Smoking Cessation Quit Line for Mental Health Patients
Status: COMPLETED
Conditions: Mental Disorder|Smoking Cessation|Motivation
Interventions: BEHAVIORAL: Psychological and psycho-educational support by phone|OTHER: Brief counselling session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cortisol Augmentation of Prolonged Exposure Therapy
Status: COMPLETED
Conditions: PTSD
Interventions: BEHAVIORAL: Prolonged Exposure therapy|DRUG: Hydrocortisone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Systemic Corticosteroids When Utilizing a Steroid-Eluting Spacer Following Endoscopic Sinus Surgery
Status: COMPLETED
Conditions: Chronic Sinusitis|Endoscopic Sinus Surgery|Post-operative Care|Steroids|Drug-eluting Spacer
Interventions: DEVICE: Steroid-eluting middle meatal spacer (Nasopore (TM) spacer impregnated with 1 cc of 40mg/mL triamcinolone liquid)|DRUG: Post-op Oral Steroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Ganglion Block to Prevent Shoulder Pain After Laparoscopic Bariatric Surgery
Status: WITHDRAWN
Conditions: Obesity
Interventions: DRUG: 4% Lidocaine|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Diuretics for Postpartum High Blood Pressure in Preeclampsia
Status: COMPLETED
Conditions: Preeclampsia
Interventions: DRUG: FUROSEMIDE|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Group Study of the Safety of and Immune Response to a Single Dose of Bird Flu Vaccine (H7N3) in Healthy Adults
Status: COMPLETED
Conditions: Influenza|Virus Diseases
Interventions: BIOLOGICAL: Live Influenza A Vaccine H7N3 (6-2) AA ca Recombinant (A/chicken/British Columbia/CN-6/2004 x A/Ann Arbor/6/60 ca)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: In-vitro Study to Assess the Coagulation Effects of Exogenous Oxytocin Using Thromboelastography.
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Final exogenous oxytocin concentration=22.5 μU/mL|DRUG: Final exogenous oxytocin concentration=30.1μU/mL|DRUG: Final exogenous oxytocin concentration=32.9μU/mL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Capecitabine and Mitomycin C in Treatment of Patients With Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Metastasis
Interventions: DRUG: Capecitabine and Mitomycin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Intervention to Address Stigma Among Pregnant Adolescents Living With HIV
Status: ACTIVE_NOT_RECRUITING
Conditions: Mother to Child Transmission|Pregnancy in Adolescence|Social Stigma|Self Disclosure|HIV
Interventions: BEHAVIORAL: Digital intervention for pregnant adolescents living with HIV
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Evaluation of Tolvaptan in the Treatment of Patients With RHF Caused by PAH
Status: UNKNOWN
Conditions: Pulmonary Arterial Hypertension|Randomized Controlled Trial
Interventions: DRUG: Tolvaptan|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CD19 /22 CAR T Cells (AUTO3) for the Treatment of B Cell Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: B Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|Refractory Childhood Acute Lymphoblastic Leukemia|B-cell Acute Lymphoblastic Leukemia
Interventions: BIOLOGICAL: AUTO3 (CD19/22 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction Study Between DWC20155 / DWC20156 and DWC20162 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Co-administration of DWC20155/DWC20156|DRUG: DWC20162
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High Frequency/Low Intensity Transcranial Magnetic Stimulation in Cognitive Traits of an Elderly Population of Subjects With Mild Cognitive Impairment and Mild Dementia.
Status: TERMINATED
Conditions: Mild Cognitive Impairment|Mild Dementia
Interventions: DEVICE: High Frequency Low Intensity TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Superiority of Contralateral Oblique View for Mid-thoracic Epidural Assess
Status: COMPLETED
Conditions: Herpes Zoster|Postherpetic Neuralgia|Cancer
Interventions: PROCEDURE: Fluoroscopic-guided TEB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Goodnight Screen Media Study
Status: RECRUITING
Conditions: Sleep|Sleep Hygiene
Interventions: BEHAVIORAL: Timed evening technology and digital media use (tablet use)|BEHAVIORAL: no technology and digital media use (screen media use)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Clamping Before Removal of a Pneumothorax Drain Connected to a Digital Drainage System.
Status: COMPLETED
Conditions: Pneumothorax and Air Leak
Interventions: OTHER: Digital drainage system|OTHER: Digital drainage system + clamping trial
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Potential of Mesenchymal Stromal Cells to Treat Obliterative Bronchiolitis After Lung Transplantation
Status: COMPLETED
Conditions: Bronchiolitis Obliterans|Lung Transplantation
Interventions: OTHER: MSC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dartmouth Middle Meningeal Embolization Trial (DaMMET)
Status: COMPLETED
Conditions: Chronic Subdural Hematoma|Subdural Hematoma
Interventions: PROCEDURE: Embolization of the Middle Meningeal Artery|PROCEDURE: Standard of care including possible surgical evacuation of subdural hematoma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Guadecitabine With or Without Idarubicin or Cladribine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Cladribine|DRUG: Guadecitabine|DRUG: Idarubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Combination Treatment With HF10 and Ipilimumab in Patients With Unresectable or Metastatic Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: HF10 plus Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutritional Strategy for Glycemic Control in Patients With Type 2 Diabetes Mellitus (NUGLIC)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Nutritional Strategy|BEHAVIORAL: Dietary Prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Impact of a Comic-based Programme to Promote Body Confidence Among Adolescents in India
Status: COMPLETED
Conditions: Body Image|Eating Disorder Symptom
Interventions: BEHAVIORAL: AdhaFULL body image comics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effects of Pre-extubation Single Recruitment Maneuver on Perioperative Atelectasis
Status: COMPLETED
Conditions: Pulmonary Atelectasis
Interventions: OTHER: Recruitment maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Singing Training for Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: Singing training|BEHAVIORAL: Physical Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 3 Clinical Trial: D-methionine to Reduce Noise-Induced Hearing Loss (NIHL)
Status: TERMINATED
Conditions: Noise-induced Hearing Loss
Interventions: DRUG: D-methionine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Single Dose of 2L PEG on Bowel Preparation in Average-risk Patients Undergoing Colonoscopy
Status: COMPLETED
Conditions: Health Behavior
Interventions: DRUG: Single dose of 2L PEG|DRUG: Split dose of 4L PEG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Trial of Type II Collagen (CII) APL A12 in Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: APLA12|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isatuximab With or Without Lenalidomide in Patients With High Risk Smoldering Multiple Myeloma (ISAMAR)
Status: ACTIVE_NOT_RECRUITING
Conditions: Smoldering Plasma Cell Myeloma
Interventions: BIOLOGICAL: Isatuximab|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Tolerability and Pharmacokinetics After Single Doses of AZD1446 to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD1446
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study on the Immunogenicity and Tolerability of Influsplit SSW® 2005/2006 in Children Aged 6 - 13 Years
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influsplit SSW® 2005/2006
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Tornier Shoulder Outcomes Study to Examine Safety and Functional Outcomes in Shoulder Arthroplasty and Fracture Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Shoulder Arthroplasty and Fracture Repair
Interventions: DEVICE: Shoulder Arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK)
Status: UNKNOWN
Conditions: Fuchs' Endothelial Dystrophy|Bullous Keratopathy
Interventions: PROCEDURE: Intraocular gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Whether Correction of Anemia Using Recombinant Human Erythropoietin Reduces the Progression of Atherosclerosis and Cardiac Hypertrophy in Pre-dialysis Chronic Kidney Disease Patients
Status: COMPLETED
Conditions: Chronic Disease|Kidney Diseases|Cardiovascular Diseases
Interventions: DRUG: erythropoietin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effects of Instability Resistance Training Versus Aerobic Training on Cognitive and Motor Improvements Found in Parkinson's Disease Participants
Status: UNKNOWN
Conditions: Exercise|Parkinson Disease
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Bupropion and Specific Cardiovascular Malformations
Status: COMPLETED
Conditions: Depressive Disorder|Pregnancy|Smoking Cessation
Interventions: DRUG: 3. Exposure to other antidepressants during the first trimester comparison cohort|DRUG: 2. Exposure to bupropion outside the first trimester comparison cohort|DRUG: 1. Exposure to bupropion during the first trimester
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1/ 2, First-in-Human, Open-Label, Accelerated-Titration, Two-Part Clinical Trial of TK-8001 in Patients With HLA-A*02:01 Genotype and Advanced-Stage/ Metastatic MAGE-A1+ Solid Tumors
Status: TERMINATED
Conditions: Advanced Solid Tumors
Interventions: BIOLOGICAL: Autologous CD8+ T-cells, transduced with MAGE-A1 directed TCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Relapsed or Refractory B Cell Precursor ALL
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab|DRUG: AMG 404|DRUG: Dexamethasone Premedication
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT