pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Comparison of Duloxetine Hydrochloride, Marketed Comparator, and Placebo in the Treatment of Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: Duloxetine|DRUG: venlafaxine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Study the Efficacy and Safety of Fluorothiazinone (N.F. Gamaleya NRCEM) in Prophylaxis of Nosocomial Bacterial Infections With Participation of Patients on MV
Status: NOT_YET_RECRUITING
Conditions: Gram Negative Pneumonia|Gram-Negative Bacterial Infections|Bacteremia Caused by Gram-Negative Bacteria
Interventions: DRUG: Fluorothiazinone, tablets 300 mg at a dose of 2400 mg/day|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of BOL-303242-X Versus Vehicle for the Treatment of Inflammation Following Cataract Surgery
Status: COMPLETED
Conditions: Cataract|Inflammation
Interventions: DRUG: BOL-303242-X|DRUG: Vehicle for BOL-303242-X
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Melphalan in Patients With Neoplastic Meningitis
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Extragonadal Germ Cell Tumor|Leukemia|Lymphoma|Ovarian Cancer
Interventions: DRUG: melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Bilateral Two Levels Serratus Anterior Plane Block in Pediatric Cardiac Surgery With Median Sternotomy
Status: NOT_YET_RECRUITING
Conditions: Congenital Heart Disease
Interventions: PROCEDURE: Bilateral two level serratus anterior block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Diva - The Effects Of 12 Weeks Of Treatment With High Dose Valsartan (320 Mg) To Amlodipine On Endothelial Function In Hypertensive Subjects With The Metabolic Syndrome
Status: COMPLETED
Conditions: Hypertension|Metabolic Syndrome
Interventions: DRUG: VALSARTAN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PEAK PlasmaBlade™ vs. Traditional Electrosurgery in Abdominoplasty
Status: COMPLETED
Conditions: Elastosis
Interventions: DEVICE: PEAK PlasmaBlade|PROCEDURE: Standard of Care (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Serum 25-hydroxy Vitamin D [25(OH)D] Levels, Supplemental Vitamin D, and Parathyroid Hormone Levels in Premature Infants
Status: COMPLETED
Conditions: Premature Infants
Interventions: DIETARY_SUPPLEMENT: cholecalciferal|DIETARY_SUPPLEMENT: cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment for Hallux Rigidus
Status: COMPLETED
Conditions: Hallux Limitus|Hallux Rigidus
Interventions: RADIATION: Joint Resection- Keller Procedure|PROCEDURE: Joint Fusion|PROCEDURE: Hemi-metallic Joint Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endovascular Exclusion of TAAA/AAA Utilizing Fenestrated/Branched Stent Grafts
Status: COMPLETED
Conditions: Thoracoabdominal Aneurysm|Abdominal Aortic Aneurysm
Interventions: DEVICE: Endovascular Aneurysm Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Randomized Trial Evaluating Neoadjuvant Therapy With Neratinib and/or Trastuzumab Followed by Postoperative Trastuzumab in Women With Locally Advanced HER2-positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Trastuzumab|DRUG: Neratinib|DRUG: Doxorubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Levetiracetam in Epileptic Pediatric Subjects Ranging in Age From 1 Month to Less Than 4 Years Old
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Pharmacokinetic Study of TAK-536 (Azilsartan) in Pediatric Patients 6 to Less Than 16 Years With Hypertension
Status: COMPLETED
Conditions: Pediatric Hypertension
Interventions: DRUG: Azilsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Segmentation of PGD Treatment
Status: UNKNOWN
Conditions: Clinical Pregnancy|Live Birth
Interventions: PROCEDURE: elective cryopreservation of available embryos after PGD|PROCEDURE: PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Combination of Tacrolimus and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
Status: UNKNOWN
Conditions: Immune Thrombocytopenia
Interventions: DRUG: TAC|DRUG: Danazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chloroquine Diphosphate in the Prevention of SARS in Covid-19 Infection
Status: COMPLETED
Conditions: COVID-19|SARS-CoV Infection|Severe Acute Respiratory Syndrome (SARS) Pneumonia|Clinical Trial
Interventions: DRUG: Chloroquine Diphosphate|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Preliminary Efficacy With BAT6026 in Solid Tumour Patients
Status: TERMINATED
Conditions: Advanced Solid Tumour
Interventions: DRUG: BAT6026|DRUG: BAT1308
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Physical Exercise in Cardiac Rehabilitation
Status: COMPLETED
Conditions: Coronary Heart Disease|Heart Failure|Ischemic Heart Diseases
Interventions: OTHER: Supervised physical exercise training x3 weekly for 12 weeks|OTHER: Supervised physical exercise training x2 weekly for 8 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Schroth and Klapp Method in CP Children With Scoliosis
Status: COMPLETED
Conditions: Cerebral Palsy|Scoliosis
Interventions: OTHER: Schroth Exercises|OTHER: Klapp Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess Single and Repeat Doses of a New Medication (GSK933776) in Patients With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: GSK933776|DRUG: Placebo to match GSK933776
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen Therapy Registry
Status: UNKNOWN
Conditions: Air or Gas Embolism|Carbon Monoxide Poisoning|Clostridial Myositis and Myonecrosis (Gas Gangrene)|Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias|Decompression Sickness|Peripheral Arterial Insufficiency and Central Retinal Artery Occlusion|Severe Anemia|Intracranial Abscess|Necrotizing Soft Tissue Infections|Osteomyelitis (Refractory)|Delayed Radiation Injury (Soft Tissue and Bony Necrosis)|Compromised Grafts and Flaps|Acute Thermal Burn Injury|Idiopathic Sudden Sensorineural Hearing Loss
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of ACEI in Alport Syndrome Patients With COL4A3/COL4A4/COL4A5 Variants
Status: NOT_YET_RECRUITING
Conditions: Alport Syndrome
Interventions: DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-Titration Study of Sevelamer Carbonate in Chronic Kidney Disease (CKD) Patients on Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Kidney Disease on Hemodialysis
Interventions: DRUG: Placebo|DRUG: Sevelamer carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Proof of Concept Study of Electrical Discharge Produced Nitric Oxide for Inhalation
Status: COMPLETED
Conditions: Hypertension, Pulmonary
Interventions: DEVICE: electrical pulsed plasma discharge synthesis of nitric oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Promoting Safe Medication Use in Pregnancy in the Era of Real-World Data - The SafeStart Study
Status: COMPLETED
Conditions: Pregnancy Early|Emesis|Medication Adherence
Interventions: OTHER: Pharmacist consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
Status: RECRUITING
Conditions: Liver Transplant
Interventions: DRUG: Everolimus|DRUG: Tacrolimus (continued reduction)|DRUG: Tacrolimus (maintain 50% reduction)|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREGNANT Short Cervix Trial
Status: COMPLETED
Conditions: Preterm Delivery|Short Cervix|Short Uterine Cervical Length
Interventions: DRUG: progesterone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy, Bev, RT, and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: carboplatin|DRUG: erlotinib hydrochloride|DRUG: paclitaxel|RADIATION: 3-dimensional conformal radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Effectiveness and Safety of Hyaluronic Acid (HA) Fillers
Status: COMPLETED
Conditions: Volume Deficiency of the Midface
Interventions: DEVICE: Restylane Volyme|DEVICE: Restylane Defyne|DEVICE: Restylane Lyft Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Supplementation to Both Parent and Adolescent
Status: RECRUITING
Conditions: Behavior Problems
Interventions: DIETARY_SUPPLEMENT: Smartfish Omega|DIETARY_SUPPLEMENT: Smartfish Fruit Juice Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Platelet Rich Plasma on Outcome of Narrow Band UVB in Treatment of Vitiligo; Clinical and Histopathological Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Management of Stable Vitiligo
Interventions: PROCEDURE: platelet rich plasma, narrow band UVB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial Of PS-341 (Bortezomib) In Patients With Previously Treated Advanced Urothelial Tract Transitional Cell Carcinoma
Status: COMPLETED
Conditions: Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter|Recurrent Bladder Cancer|Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter|Recurrent Urethral Cancer|Stage III Bladder Cancer|Stage III Urethral Cancer|Stage IV Bladder Cancer|Stage IV Urethral Cancer|Transitional Cell Carcinoma of the Bladder|Ureter Cancer
Interventions: DRUG: bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Online Intervention Targeting Depression and Low Reward Sensitivity
Status: COMPLETED
Conditions: Depression Mild|Depression Moderate
Interventions: BEHAVIORAL: Behavioral Activation|BEHAVIORAL: Mindulness and Gratitude|BEHAVIORAL: Combination of Behavioral Activation and Mindfulness and Gratitude
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Automatic Surveillance System on Surveillance Rate of Colorectal Postpolypectomy Patients
Status: NOT_YET_RECRUITING
Conditions: Artificial Intelligence|Surveillance
Interventions: OTHER: AI based automatic surveillance (AS) system (ENDOANGEL-AS) reminds the patients through by telephone .|OTHER: AI based automatic surveillance (AS) system (ENDOANGEL-AS) reminds the patients through message.|OTHER: Manually remind the patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of Colquhounia Root Tablet in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Colquhounia Root Tablet|DRUG: Methotrexate tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Complications Related to Primary or Interval Debulking in Ovarian Neoplasm
Status: COMPLETED
Conditions: Stage IIIC Ovarian Cancer
Interventions: DRUG: Neoadjuvant chemotherapy + Interval Debulking Surgery|PROCEDURE: Primary Debulking Surgery + Adjuvant Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identification of Early Markers of Response and Resistance to Trastuzumab
Status: COMPLETED
Conditions: Untreated Human Epidermal Growth Factor Receptor-2(HER2)Positive Early Breast Cancer
Interventions: OTHER: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of the Safety and Effectiveness of Rabeprazole in Treatment of Helicobacter Pylori Infection in Adults.
Status: COMPLETED
Conditions: Helicobacter Infections|Bacterial Infections
Interventions: DRUG: rabeprazole sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide Maintenance Therapy in Patients With Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)
Status: TERMINATED
Conditions: Myelodysplastic Syndromes|Acute Myelogenous Leukemia
Interventions: DRUG: lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Soy Estrogens to Prevent Bone Loss and Other Menopausal Symptoms
Status: COMPLETED
Conditions: Menopause|Osteoporosis|Osteopenia
Interventions: DIETARY_SUPPLEMENT: Soy isoflavones|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Study of Palonosetron in Radiation Induced Nausea and Vomiting (RINV)
Status: COMPLETED
Conditions: Nausea|Vomiting
Interventions: DRUG: Palonosetron|RADIATION: Low or moderate risk radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ESPB and RIB for Pain Management Following Mastectomy Surgery
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasms|Breast Cancer Female
Interventions: OTHER: Analgesia management; group ESPB and RIB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brolucizumab vs. Aflibercept for Retinal Angiomatous Proliferation
Status: WITHDRAWN
Conditions: Wet Macular Degeneration
Interventions: DRUG: Aflibercept 40 MG/ML [Eylea]|DRUG: Brolucizumab-Dbll 120 MG/ML [Beovu]|DRUG: Ranibizumab 6 MG/ML [Lucentis]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Intravitreal LFG316 in Wet Age Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Neovascular Age-elated Macular Degeneration (Wet AMD)|Exudative Macular Degeneration
Interventions: DRUG: LFG316|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Surviving PEA in Roanoke (SPEAR) Study
Status: RECRUITING
Conditions: Cardiac Arrest|Pulseless Electrical Activity
Interventions: DRUG: High Calcium, Low Sodium (HCLS) Crystalloid Therapy|DRUG: High Calcium, High Sodium (HCHS) Crystalloid Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Regional Anesthesia Techniques for Up and Early Discharge Following Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Arthroplasty, Replacement, Knee
Interventions: DRUG: Ropivacaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Loss and Mechanisms of Impaired Glucose Metabolism
Status: COMPLETED
Conditions: Primary Insomnia
Interventions: DRUG: eszopiclone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of NNC0142-0002 in Subjects With Rheumatoid Arthritis (RA)
Status: COMPLETED
Conditions: Inflammation|Rheumatoid Arthritis
Interventions: DRUG: NNC0142-0002|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A LUNG-MAP Treatment Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: DRUG: Selpercatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ZKAB001 for Maintenance Therapy in Patients With High-grade Osteosarcoma After Adjuvant Chemotherapy
Status: UNKNOWN
Conditions: High-grade Osteosarcoma
Interventions: BIOLOGICAL: Recombinant human anti-PD-L1 monoclonal antibody (ZKAB001)|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)
Status: COMPLETED
Conditions: Essential Tremor
Interventions: DRUG: JZP385|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance and Effect of a Prophylactical Treatment With Ivy Leaves Dry Extract in Recurrent Wheezy Bronchitis
Status: UNKNOWN
Conditions: Acute Wheezy Bronchitis|Recurrent Bronchitis
Interventions: DRUG: Prospan Syrup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Bioequivalence of Two Tablet Forms of MK0431 (0431-027)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin phosphate anhydrous formulation|DRUG: Comparator: sitagliptin phosphate monohydrate form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Effectiveness of Smaller Gauge Fenestrated Catheters for Use in IV Contrast Enhanced CT Scans
Status: COMPLETED
Conditions: Contrast Enhanced Computed Tomography
Interventions: DEVICE: 20GA BD Nexiva Diffusics|DEVICE: 18GA Conventional Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety Trial of Topical Resiquimod Gel (0.06%) in Patients With Nodular Basal Cell Carcinoma
Status: TERMINATED
Conditions: Nodular Basal Cell Carcinoma
Interventions: DRUG: 0.06% Resiquimod Gel - A|DRUG: 0.06% Resiquimod Gel - B|DRUG: 0.06% Resiquimod Gel - C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Safety Study of an Oral EGFR Inhibitor, AV-412, Administered Three Times Weekly in Advanced Solid Tumor Patients
Status: COMPLETED
Conditions: Advanced Cancer|Refractory Cancer
Interventions: DRUG: AV-412
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Interferon Alfa in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: recombinant interferon alfa-2b|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: GENETIC: Genotype Detection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients
Status: COMPLETED
Conditions: ARDS
Interventions: DRUG: cisatracurium|DRUG: Placebo|DRUG: Cisatracurium besilate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect Of Myofascial Release Technique With Ultrasound Therapy in Adults With Nonspecific Low Back Pain.
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DIAGNOSTIC_TEST: Myofascial Release Technique|OTHER: Ultrasound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Pharmacokinetics/Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shock
Status: UNKNOWN
Conditions: Septic Shock
Interventions: DRUG: Daptomycin|OTHER: determination of plasma concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Narrow Band Spectrum Endoscopy for the Diagnosis of Gastric Antral Vascular Ectasia in Patients With Liver Cirrhosis
Status: COMPLETED
Conditions: Gastric Antral Vascular Ectasia
Interventions: DIAGNOSTIC_TEST: Upper gastrointestinal endoscopy and biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OMT of Somatic Dysfunction and Chronic Low Back Pain in Patients With Type 2 Diabetes Mellitus
Status: TERMINATED
Conditions: Chronic Low Back Pain|Type 2 Diabetes Mellitus
Interventions: OTHER: Osteopathic Manual Treatment (OMT)|OTHER: Sham OMT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ABT-767 in Subjects With Breast Cancer 1 and Breast Cancer 2 (BRCA 1 and BRCA 2) Mutations and Solid Tumors or High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube|Primary Peritoneal Cancer|Solid Tumors (e.g. Breast, Ovarian, Prostate, or Pancreatic) and Ovarian
Interventions: DRUG: ABT-767
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients
Status: COMPLETED
Conditions: Postoperative Pain|Lung Cancer|Video Assisted Thoracoscopic Surgery|Thoracoscopic Surgery|Nerve Block|Local Anesthesia
Interventions: DRUG: Dexamethasone|DRUG: Bupivacain
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Evaluation of Sirolimus-eluting Versus Everolimus-eluting Stent Trial
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Everolimus-eluting stent|DEVICE: Sirolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-PD(L)1 and SBRT in the Treatment of Advanced, Platinum-Refractory Urothelial Carcinoma
Status: TERMINATED
Conditions: Urothelial Carcinoma
Interventions: DRUG: Pembrolizumab|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conservative Treatment Versus Elective Repair of Umbilical Hernia in Patients With Ascites and Liver Cirrhosis
Status: UNKNOWN
Conditions: Umbilical Hernia|Liver Cirrhosis|Ascites
Interventions: PROCEDURE: Conservative treatment|PROCEDURE: Surgical repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: WorkUp. Structured Care With Workplace Interventions to Improve Work Ability in Patients With Neck and/or Low Back Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Back Pain|Neck Pain
Interventions: OTHER: Structured care & workplace intervention|OTHER: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Dose Naltrexone for Metastatic Melanoma, Castrate Resistant Prostate Cancer and Renal Cancer
Status: TERMINATED
Conditions: Melanoma|Prostate Cancer|Renal Cancer
Interventions: DRUG: Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Enteral Colostrum on Clinical Outcomes in Critically Ill Patients
Status: COMPLETED
Conditions: Critical Illness|Infection Complication|Multiple Organ Dysfunction Syndrome
Interventions: DIETARY_SUPPLEMENT: Colostrum|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Selective Cytopheretic Device (SCD) in Pediatric Patients With Acute Kidney Injury (AKI).
Status: COMPLETED
Conditions: Acute Kidney Injury
Interventions: DEVICE: SCD-F40
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Topical R333 in Patients With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Lesions
Status: COMPLETED
Conditions: Lupus Erythematosus, Discoid|Lupus Erythematosus, Systemic
Interventions: DRUG: R932333|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TolTwiCare : Qualitative Evaluation Routine Care From Primary Tolerance of a Prefabricated and Removable Orthosis
Status: COMPLETED
Conditions: Dentofacial Functional Disorder
Interventions: DEVICE: TwiCare®.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Umbilical Cord Mesenchymal Stem Cells Transplantation for Patients With Decompensated Liver Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: BIOLOGICAL: conventional therapy plus low dose hUC-MSCs treatment|BIOLOGICAL: conventional therapy plus medium dose hUC-MSCs treatment|BIOLOGICAL: conventional therapy plus high dose hUC-MSCs treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty
Status: TERMINATED
Conditions: Sleep Apnea, Obstructive|Respiration Disorders
Interventions: PROCEDURE: supraglottoplasty with laser|PROCEDURE: supraglottoplasty with laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Virtual Reality Gaming Therapy Versus CI Therapy for Upper Extremity Rehabilitation
Status: COMPLETED
Conditions: Stroke|Hemiparesis
Interventions: BEHAVIORAL: Traditional CI Therapy|BEHAVIORAL: Gaming CI Therapy|BEHAVIORAL: Gaming CI Therapy with Additional Contact via Video Conference|BEHAVIORAL: Traditional Occupational Therapy/Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optic Neuritis Recovery After Oral or IV Corticosteroids
Status: COMPLETED
Conditions: Optic Neuritis
Interventions: DRUG: corticosteroids|DRUG: corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Orifice Transgastric Endoscopic (NOTES) Transgastric Diagnostic Peritoneoscopy With Laparoscopic Assistance
Status: COMPLETED
Conditions: Abdominal Adhesions
Interventions: DEVICE: Transgastric diagnostic peritoneoscopy with laparoscopic assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Noninvasive Spinal Cord Stimulation for Neurogenic and Idiopathic Overactive Bladder
Status: WITHDRAWN
Conditions: Overactive Bladder|Incontinence, Urge|Neurogenic Bladder
Interventions: DEVICE: Noninvasive spinal cord stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Impact of an Improved Chulha on Respiratory Health of Women and Children in Indian Slums
Status: TERMINATED
Conditions: Signs and Symptoms, Respiratory|Air Pollution, Indoor
Interventions: OTHER: TEJ (Traditional stove to Efficient stove in Jhuggi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pembrolizumab in Treating Participants With Recurrent Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
Status: NOT_YET_RECRUITING
Conditions: Scoliosis Correction|Esketamine|Dexmedetomidine|Postoperative Analgesia|Chronic Postsurgical Pain
Interventions: DRUG: Esketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility, Safety, and Effectiveness of the ACURATE neo2 Transcatheter Heart Valve for Severe Bicuspid Aortic Stenosis
Status: ENROLLING_BY_INVITATION
Conditions: Aortic Stenosis|Transcatheter Aortic Valve Implantation|Bicuspid Aortic Valve|Transcatheter Aortic Valve Replacement
Interventions: DEVICE: Transcatheter Aortic Valve Implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ankle Pain and Orientation After High Tibial Osteotomy as a Treatment of Medial Compartment Knee Osteoarthritis
Status: UNKNOWN
Conditions: Investigate the Change in the Weight-bearing-line (WBL) Ratio of the Ankle Joint and Ankle Joint Line Orientation After HTO
Interventions: PROCEDURE: High tibial osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing a Digital Child Mental Health Screening, Literacy, and Management Tool in Faith-Based Settings
Status: COMPLETED
Conditions: Mental Health
Interventions: BEHAVIORAL: Faith Based Outreach (FBO)|BEHAVIORAL: community-health-workers (CHW)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Geodon for the Treatment of Refractory Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: Ziprasidone|DRUG: Sertraline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Antitumor Activity of CX-2009 Monotherapy and in Combination With CX-072 in Advanced Breast Cancer
Status: COMPLETED
Conditions: Neoplasms|Breast Neoplasms|Breast Neoplasms, Triple-Negative|Breast Cancer|Breast Neoplasms, Hormone Receptor Positive/HER2 Negative
Interventions: DRUG: CX-2009|DRUG: CX-072
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Status: COMPLETED
Conditions: Dental Caries|Denture, Partial, Removable
Interventions: DEVICE: Nobio composite|DEVICE: traditional composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes of FEVAR and BEVAR to Treat Secondary Type 1 Endoleak After EVAR: A Prospective Multicentre Study
Status: COMPLETED
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: Branched / fenestrated aortic stent graft
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Imatinib and 5-FU/Leucovorin in Patients With Advanced Carcinoma of the Gallbladder and Bile Duct
Status: COMPLETED
Conditions: Advanced or Metastatic Cholangiocellular Carcinoma and Bile Duct
Interventions: DRUG: Glivec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis Patients
Status: UNKNOWN
Conditions: End Stage Renal Disease|Peritoneal Dialysis
Interventions: DRUG: Spironolactone|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Lenalidomide With Vorinostat in Pediatric Patients With High Grade or Progressive CNS Tumors
Status: TERMINATED
Conditions: Central Nervous System Tumors
Interventions: DRUG: 25 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)|DRUG: 50 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)|DRUG: 100 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)|DRUG: 150 mg/m2 Lenalidomide (Revlimid®) and 180 mg/m2 Vorinostat (Zolinza®)|DRUG: 150 mg/m2 Lenalidomide (Revlimid®) and 230 mg/m2 Vorinostat (Zolinza®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Metformin in Individuals With Fragile X Syndrome (Met)
Status: RECRUITING
Conditions: Fragile X Syndrome|Fragile X Mental Retardation Syndrome|Mental Retardation, X-Linked|Genetic Diseases, X-Linked|Trinucleotide Repeat Expansion|Fra(X) Syndrome|Intellectual Disability|FXS|Neurobehavioral Manifestations|Sex Chromosome Disorders
Interventions: DRUG: Placebo Medication|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Management in Stroke Following Endovascular Treatment
Status: COMPLETED
Conditions: Stroke, Acute|Vessels; Occlusion|Blood Pressure|Endovascular Thrombectomy|Mechanical Thrombectomy
Interventions: DRUG: Labetalol|DRUG: Hydralazine|DRUG: Enalapril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy of F16IL2 and Paclitaxel in Solid Tumour Patients
Status: COMPLETED
Conditions: Solid Tumor|Breast Cancer|Metastatic Melanoma|Non-small Cell Lung Cancer (NSCLC)
Interventions: DRUG: F16IL2 in combination with paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).
Status: TERMINATED
Conditions: Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Interventions: DRUG: macitentan 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is it Possible to Prolong the Duration of Breastfeeding in Premature Infants? a Prospectivt Study
Status: COMPLETED
Conditions: Breast Feeding|Premature Birth
Interventions: OTHER: Oralstimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Safety and Efficacy for the Eustachian Tube Balloon Catheter
Status: COMPLETED
Conditions: Eustachian Tube Dysfunction
Interventions: DEVICE: Acclarent Eustachian Tube Balloon Catheter (ETBC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Antibacterial Effect of Laser Diode and Zinc Oxide Nano Particles in Cavity Disinfection
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: zinc oxide nano-particles|DEVICE: laser diode
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sunitinib Malate and Exemestane in Treating Postmenopausal Women With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: exemestane|DRUG: sunitinib malate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
Status: RECRUITING
Conditions: Mesial Temporal Lobe Epilepsy
Interventions: GENETIC: AAV9-hSyn1-miGRIK2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two-stent vs Provisional Stenting Techniques for Patients With Complex Coronary Bifurcation Lesions
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Compared to Ketofol for Sedation in Paediatrics
Status: COMPLETED
Conditions: Vital Signs
Interventions: DRUG: Ketamine/ propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy
Status: COMPLETED
Conditions: Traumatic Brain Injury|Fatigue
Interventions: DEVICE: Bright White Light (BWL)|DEVICE: Dim Red Light (DRL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Therapy for Stage II-IVA Resectable Esophageal Squamous Cell
Status: RECRUITING
Conditions: Neoadjuvent|PD-1 Inhibitor|Chemotherapy|Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab, Albumin Paclitaxel, 5-fluorouracil, Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gynaecological Follow-up of a Subset of 580299/008 (NCT00122681) Study Subjects
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: OTHER: Gynaecological follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dasatinib as First-Line Therapy in Treating Patients With Gastrointestinal Stromal Tumors
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor
Interventions: DRUG: dasatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Day Regimes of CONbercept on CytokinEs of PDR Patients Undergoing Vitrectomy - Trial (CONCEPT)
Status: UNKNOWN
Conditions: Proliferative Diabetic Retinopathy|VEGF Overexpression
Interventions: DRUG: IVC|PROCEDURE: Blood and aqueous humor at the time of IVC|PROCEDURE: Collect blood, aqueous humor, and initial vitreous at the time of surgery.|PROCEDURE: IVC-sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NY-ESO-1 Specific T Cells After Cyclophosphamide in Treating Patients With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
Status: WITHDRAWN
Conditions: Adult Synovial Sarcoma|Myxoid/Round Cell Liposarcoma|Recurrent Adult Soft Tissue Sarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: BIOLOGICAL: Autologous NY-ESO-1-specific CD8-positive T Lymphocytes|DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A nUtrition and Lifestyle Intervention in Patients With Pulmonary Arterial HypertensIon
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: BEHAVIORAL: E-learning|DIETARY_SUPPLEMENT: Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Plerixafor in Elderly Acute Myeloid Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: plerixafor|DRUG: decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Metformin Versus Repaglinide Treatment in Non-Obese Type 2 Diabetic Patients Uncontrolled by Diet
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin|DRUG: Repaglinide|DRUG: Placebo-Metformin.|DRUG: Placebo-Repaglinide.|OTHER: Diet-only.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Automatized and the Optimized Carbon Monoxid Rebreathing Protocol
Status: UNKNOWN
Conditions: Hemoglobins
Interventions: DEVICE: Automatized carbonmonoxide rebreathing machine - OpCO Detalo instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of SPL7013 Gel to Prevent the Recurrence of Bacterial Vaginosis (BV)
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: Metronidazole oral tablets 500mg|DRUG: 1% SPL7013 Gel|DRUG: Placebo gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor
Status: RECRUITING
Conditions: Prostatic Neoplasms|Prostate Cancer|Prostate Adenocarcinoma
Interventions: DRUG: 18F-DCFPyL|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Protontherapy of Cervical and Endometrial Carcinomas
Status: UNKNOWN
Conditions: Uterine Cervical Neoplasms|Endometrial Neoplasms Malignant
Interventions: RADIATION: Adjuvant pelvic proton radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT