pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Aspartame|DIETARY_SUPPLEMENT: Sucrose|DIETARY_SUPPLEMENT: Stevia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: SCD Use to Prevent Deep Venous Thrombosis (DVT) in Patients With PICC Lines
Status: TERMINATED
Conditions: Deep Vein Thrombosis
Interventions: DEVICE: Pneumatic SCD - VenaFlow System (DJO Global)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Comparision of Minimally-invasive and Open Pancreaticoduodenectomy for Pancreatic Cancer
Status: RECRUITING
Conditions: Pancreatic Carcinoma|Surgery
Interventions: PROCEDURE: Minimally-invasive pancreaticoduodenectomy|OTHER: Open pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Sports Supplements on Metabolism and Perceptual Responses During Distance Running
Status: RECRUITING
Conditions: Anomalies Gastrointestinal
Interventions: DIETARY_SUPPLEMENT: Carbohydrate Beverage|DIETARY_SUPPLEMENT: Placebo Beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Tafasitamab and Lenalidomide Followed by Tafasitamab and ICE as Salvage Therapy for Transplant Eligible Patients With Relapsed/ Refractory Large B-Cell Lymphoma
Status: RECRUITING
Conditions: Recurrent B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma|Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Recurrent Grade 3b Follicular Lymphoma|Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Recurrent High Grade B-Cell Lymphoma, Not Otherwise Specified|Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type|Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma|Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma|Recurrent Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma|Refractory B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma|Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified|Refractory Grade 3b Follicular Lymphoma|Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements|Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements|Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified|Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type|Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma|Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma|Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma|Refractory Transformed Marginal Zone Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Computed Tomography|DRUG: Etoposide|DRUG: Ifosfamide|DRUG: Lenalidomide|PROCEDURE: Positron Emission Tomography|BIOLOGICAL: Tafasitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of a New Tablet Formulation of CPI-444 in Fed and Fasted Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: CPI-444 Capsules|DRUG: CPI-444 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Role of UC-MSC and CM to Inhibit Vision Loss in Retinitis Pigmentosa Phase I/II
Status: RECRUITING
Conditions: Retinitis Pigmentosa
Interventions: BIOLOGICAL: 1.5 x 10^6 UC-MSC + CM|BIOLOGICAL: 5 x 10^6 UC-MSC + CM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer Patients
Status: RECRUITING
Conditions: Prostate Cancer|Prostate Cancer Metastatic|Prostate Adenocarcinoma
Interventions: DRUG: Relugolix Pill|DRUG: Ritonavir|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Osimertinib Combined With Aspirin Neoadjuvant Therapy for Resectable EGFR Mutated NSCLC Patients.
Status: NOT_YET_RECRUITING
Conditions: Non Small Cell Lung Cancer|EGFR Gene Mutation
Interventions: DRUG: Osimertinib|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib, Busulfan and Fludarabine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Cyclophosphamide|BIOLOGICAL: Filgrastim|DRUG: Fludarabine|DRUG: Mycophenolate Mofetil|DRUG: Sorafenib|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PREDICT-SpA - French Epidemiological Study of the Evaluation of the Impact of Fibromyalgia in the TNF Alpha Treatment Effect in Axial Spondyloarthritis in Both Anti-TNF naïve and - Experienced Patients
Status: COMPLETED
Conditions: Axial Spondyloarthritis|Fibromyalgia
Interventions: OTHER: Follow-up after 12 weeks after TNF alpha blockers initiation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Compare Milk Protein Isolate (MPI) With Caseinate in Terms of Protein Utilization
Status: COMPLETED
Conditions: Enteral Feeds
Interventions: DIETARY_SUPPLEMENT: Caseinate|DIETARY_SUPPLEMENT: Milk Protein Isolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety & Effectiveness of Clobex Spray, Followed by Calcitriol Ointment in Management of Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: clobetasol propionate spray 0.05%|DRUG: calcitriol ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of AC-170 for the Treatment of Allergic Conjunctivitis in the Conjunctival Allergen Challenge (CAC) Model
Status: COMPLETED
Conditions: Allergic Conjunctivitis
Interventions: DRUG: AC-170 0.05%|DRUG: AC-170 0.1%|DRUG: AC-170 0.24%|DRUG: AC-170 0%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Efficacy of ABX203 Therapeutic Vaccine in HBeAg Negative Patients With Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ABX203 therapeutic Hepatitis B vaccine treatment arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reproductive Outcome in Assisted Conception Cycles
Status: COMPLETED
Conditions: Infertility
Interventions: DIAGNOSTIC_TEST: follicular stimulating hormone|DIAGNOSTIC_TEST: Anti-mullerian hormone|RADIATION: Basal antral follicle count
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Paclitaxel|DRUG: RO5509554
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study for Participants of MACI00206 Study of MACI® for the Treatment of Symptomatic Articular Cartilage Defects of the Knee
Status: COMPLETED
Conditions: Articular Cartilage Defects
Interventions: BIOLOGICAL: autologous cultured chondrocytes on porcine collagen membrane|PROCEDURE: Microfracture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: I-125 Seeds Loaded Stent Insertion for Inoperable Hilar Cholangiocarcinoma
Status: UNKNOWN
Conditions: Hilar Cholangiocarcinoma
Interventions: DEVICE: I-125 seeds loaded stent (self-expanded metal stent with I-125 seeds, Micro-Tech, Nanjing, China)|DEVICE: Normal stent (self-expanded metal stent without I-125 seeds, Micro-Tech, Nanjing, China)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Co-Administration of Sitagliptin and Metformin in China (MK-0431-121)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin 50 mg|DRUG: Metformin 500 mg|DRUG: Sitagliptin 100 mg|DRUG: Placebo|DRUG: Metformin 850 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fluorescence Imaging in Finding Tumors in Patients With Kidney Tumors
Status: COMPLETED
Conditions: Recurrent Renal Cell Cancer|Stage I Renal Cell Cancer|Stage II Renal Cell Cancer
Interventions: PROCEDURE: fluorescence imaging|PROCEDURE: laparoscopic surgery|DRUG: indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Oral BIIB061 Added to Interferon-beta1 (IFN-β1) or Glatiramer Acetate in Relapsing Multiple Sclerosis (RMS)
Status: WITHDRAWN
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Placebo|DRUG: BIIB061|BIOLOGICAL: Interferon-beta1|DRUG: Glatiramer acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
Status: RECRUITING
Conditions: Major Depressive Disorder|Suicidal Ideas|Suicide, Attempted|MDD|Depression|Depression, Teen|Depression and Suicide|Depression in Adolescence|Suicide
Interventions: GENETIC: Genetic testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Transitioning Open Heart Surgery Patients From Insulin Infusions to Detemir
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Detemir|DRUG: Detemir|DRUG: Detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement
Status: RECRUITING
Conditions: AORTIC VALVE DISEASES|Thromboembolism
Interventions: DRUG: Rivaroxaban Oral Tablet|DRUG: Vitamin K antagonist(warfarin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Treatment of Chronic HCV Patients in Chronic Kidney Disease Versus End Stage Renal Disease Patients
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Ombitasvir-Paritaprevir-Ritonavir Tab 12.5-75-50 milligram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Acute Effects of Pragmatic Manual Therapy on the Range of Motion of Shoulder Joint
Status: UNKNOWN
Conditions: Shoulder Impingement|Prehabilitation|Rehabilitation
Interventions: OTHER: pragmatic manual therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polaris - Crestor 40 mg vs Atorvastatin 80 mg for 26 Weeks
Status: COMPLETED
Conditions: Hypercholesterolemia|Coronary Heart Disease
Interventions: DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Understanding of Psychotic Disorders in Children With 22q11.2DS
Status: RECRUITING
Conditions: 22q11.2 Deletion Syndrome
Interventions: BEHAVIORAL: neuropsychological testing, questionnaires and experimental tasks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Monthly Subcutaneous Mircera for the Treatment of Chronic Renal Anemia in Predialysis Patients Not Treated With ESA.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: methoxy polyethylene glycol-epoetin beta [Mircera]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Results of Six Biomaterials Used in Two-stage Maxillary Sinus
Status: COMPLETED
Conditions: Atrophy|Jaw, Edentulous, Partially|Sinus Floor Augmentation|Bone Substitutes|Bone Regeneration
Interventions: PROCEDURE: Sinus floor augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
Status: RECRUITING
Conditions: Cirrhosis, Liver|Liver Fibrosis|Ascites Hepatic
Interventions: DRUG: PHIN-214 Subcutaneous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement
Status: RECRUITING
Conditions: Opioid Use Disorder|Opioid Dependence With Current Use (Disorder)
Interventions: BEHAVIORAL: Text Message Check-ins|BEHAVIORAL: Contingency Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Bioequivalence of Tocilizumab Following Subcutaneous Administration Via an Autoinjector (AI 1000-G2) Versus a Pre-Filled Syringe in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DEVICE: AI-1000 G2|DEVICE: PFS-NSD|DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SKB264 Combinatiton Therapy in Patients With Advanced or Metastatic Non-small Cell Lung Cancer.
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: SKB264|DRUG: KL-A167|DRUG: Carboplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Guided Implant Surgery VS Static Guided Surgery.
Status: RECRUITING
Conditions: Partially Edentulous Patients|Bone Crest of at Least 10 mm Length and 6 mm Width|Patients of at Least 18 Years Old
Interventions: DEVICE: Dental implant placement|PROCEDURE: Static guided implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparing the PrePex™ Device to Surgical Circumcision for Rapid Scale Up of Male Circumcision in Resource Limited Setting
Status: COMPLETED
Conditions: HIV
Interventions: DEVICE: PrePex™ device for adult male circumcision|PROCEDURE: Surgical circumcision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intranasal PH94B for Management of the Symptoms of Generalized Social Phobia
Status: COMPLETED
Conditions: Social Phobia|Social Anxiety Disorder
Interventions: DRUG: PH94B intranasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Hybrid Robot-assisted Training Using End-effector and Exoskeleton Devices in Distal Upper Extremity After Stroke：Motor Control, Motor and Daily Function, Quality of Life
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: robot-assisted|DEVICE: Conventional rehabilitation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: From Opinion to Evidence: Multi-site Evaluation of Custom Dynamic Orthosis Best Practices
Status: RECRUITING
Conditions: Foot Injury
Interventions: DEVICE: Modular Carbon Fiber Custom Dynamic Orthosis (CDO)|DEVICE: Mono Carbon Fiber Custom Dynamic Orthosis (CDO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utility of Low Intensity Pulsed Ultrasound Stimulation (LIPUS) to Modulate the Release of Mediators Capable of Reflecting the Inflammatory State in the Affected Colonic Tract of Ulcerative Colitis Patients
Status: NOT_YET_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DEVICE: LIPUS stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Hydrogen-rich Water Compared With Placebo in Type 2 Diabetes Patients
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Hydrogen-rich water|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Autologous Adipose-Derived Regenerative Cells for the Treatment of Urethral Strictures
Status: UNKNOWN
Conditions: Urethral Strictures in Males
Interventions: OTHER: Submucosal injection of ADRC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Tolerability, and Pharmacokinetics of Multiple Doses of Oral TAK-831 in Adults With Friedreich Ataxia
Status: COMPLETED
Conditions: Friedreich Ataxia
Interventions: DRUG: TAK-831|DRUG: TAK-831 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Primovist in Chinese Patients
Status: COMPLETED
Conditions: Known or Suspected Focal Liver Lesions
Interventions: DRUG: Gadoxetic Acid Disodium (Primovist, BAY86-4873)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness and Safety of YVOIRE Y-Solution 540
Status: UNKNOWN
Conditions: Wrinkles in the Nasolabial Folds
Interventions: DEVICE: YVOIRE Y-Solution 540|DEVICE: YVOIRE volume plus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: radiation therapy|RADIATION: Whole-pelvic radiotherapy (WPRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy
Status: COMPLETED
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: PAZOPANIB|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block in Liver Transplantation Donors
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Intravenous fentanyl patient control device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunomodulatory Effect of Vitamin D in Allogenic Post-transplant
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation
Interventions: DRUG: 1000IU/day of Vitamine D|DRUG: 5000IU/day of Vitamine D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Length of the Proximal Resection Margin for Siewert-II/Siewert-III Tumors
Status: UNKNOWN
Conditions: Stomach Neoplasms|Siewert Type II Adenocarcinoma of Esophagogastric Junction|Recurrence|Siewert Type III Adenocarcinoma of Esophagogastric Junction
Interventions: PROCEDURE: gastrectomy|PROCEDURE: gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Efficacy and Safety of Long-Term Treatment and Re-Treatment of Lower Extremity Diabetic Ulcers With REGRANEX
Status: TERMINATED
Conditions: Foot Ulcer|Diabetic Foot|Skin Ulcer|Diabetic Neuropathies
Interventions: DRUG: Becaplermin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: CHRONIC OPTIC NEUROPATHY IN MULTIPLE SCLEROSIS
Status: COMPLETED
Conditions: Chronic Optic Neuropathy in Multiple Sclerosis
Interventions: PROCEDURE: • Neuro-Ophthalmological examination, Visual Acuity, Fundus, Visual Field, Color Vision, OCT, EDSS • NEI-VFQ 25 and the 10-item • VEPs, p-ERG and mf-ERG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Rituximab in IgG4-RD: A Phase 1-2 Trial
Status: COMPLETED
Conditions: Retroperitoneal Fibrosis|Autoimmune Pancreatitis|Sialadenitis|Pseudotumor
Interventions: DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis
Status: NOT_YET_RECRUITING
Conditions: Psoriatic Arthritis|Spondyloarthritis, Axial
Interventions: DRUG: Upadacitinib 15 MG [Rinvoq]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The PROTECT 2 Study : Pressure Injury Treatment by Intermittent Electrical Stimulation: A Randomized, Controlled Trial
Status: RECRUITING
Conditions: Stage 1 Pressure Ulcer|Stage 2 Pressure Ulcer
Interventions: DEVICE: Intermittent electrical stimulation system (IES) treatment and turning patient every two hours|OTHER: Turning population every two hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of n-3 PUFA Plant Oil Intake on Human Metabolism
Status: UNKNOWN
Conditions: Hyperlipidemias
Interventions: DIETARY_SUPPLEMENT: Placebo oil|DIETARY_SUPPLEMENT: Echium oil|DIETARY_SUPPLEMENT: Mixed oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bariatric SUrgery With Mesh REpair of Ventral Hernia: a Randomized Controlled Trial
Status: RECRUITING
Conditions: Ventral Hernia
Interventions: PROCEDURE: Mesh repair|PROCEDURE: Suture repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Short-Term Intensive Insulin Sequential Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: insulin lispro injection, exenatide injection|DRUG: insulin lispro injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Adenocarcinoma
Interventions: DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Leucovorin Calcium|DRUG: Fluorouracil|DRUG: Irinotecan Hydrochloride|DRUG: Irinotecan|DIETARY_SUPPLEMENT: Cholecalciferol|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Controlled Trial of Prenatal Vitamin D3 Supplementation to Prevent Vitamin D Deficiency in Mothers and Their Infants
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Prenatal Vitamin|DRUG: Cholecalciferol (Vitamin D3)|DRUG: Cholecalciferol (Vitamin D3)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: 2-Week Study In People With Nonalcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis|Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Placebo|DRUG: PF-06865571|DRUG: PF-06865571
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Energy Value of Macronutrients From Almonds and Mechanisms of Nutrient Action
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: 1.5PD almonds|OTHER: 3.0PD almonds|OTHER: Base (without almonds)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: EFFECT of WHOLE BODY VIBRATION on FUNCTIONAL CAPACITY and RESPIRATORY FUNCTIONS IN STROKE INDIVIDUALS
Status: COMPLETED
Conditions: Stroke|Respiratory Function Impaired
Interventions: OTHER: rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of EZN-2968, an Antisense Oligonucleotide Inhibitor of HIF-1alpha, in Adults With Advanced Solid Tumors With Liver Metastases
Status: COMPLETED
Conditions: Neoplasms|Liver Metastases
Interventions: DRUG: EZN-2968
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)
Status: RECRUITING
Conditions: Postural Tachycardia Syndrome|Autonomic Dysfunction|Postural Orthostatic Tachycardia Syndrome|POTS - Postural Orthostatic Tachycardia Syndrome
Interventions: DEVICE: GammaCore intervention|OTHER: STEPS management protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Examine the Effects of Erythropoietin on Left Ventricular Function After Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Buccal Tablets Versus Immediate Release Oxycodone for Breakthrough Pain in Patients With Chronic Pain
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: Fentanyl Buccal Tablet|DRUG: Immediate release oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tenofovir Disoproxil Fumarate (TDF) in HIV-1 Patients Who Have Never Taken Anti-HIV Drugs
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Food Biodiversity and Human Health
Status: NOT_YET_RECRUITING
Conditions: Oral Microbiota|Periodontal Diseases
Interventions: OTHER: Einkorn Diet|OTHER: Intermediate oral microbiota|OTHER: Periodontal health status|OTHER: General health status
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HFNO Reduces Hypoxia During Sedated Gastroscopy or Colonoscopy in High Risk Patients
Status: UNKNOWN
Conditions: Gastric Cancer|Intestinal Cancer|Intestine Adenoma|Gastritis
Interventions: DEVICE: High-flow nasal cannula oxygenation|DEVICE: Regular nasal cannula oxygenation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Continuously Infused Intracerebral (IC) Recombinant-Methionyl Human Glial Cell Line-Derived Neurotrophic Factor (r-metHuGDNF) for the Treatment of Idiopathic Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: recombinant-methionyl human glial cell line-derived neurotrophic factor
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of NMB Drug Ejecting Balloon for Arteriovenous Fistulae
Status: UNKNOWN
Conditions: Obstructive Lesions of Arteriovenous Dialysis Fistulae
Interventions: DEVICE: NMB Paclitaxel Drug Ejecting Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Efficacy and Safety of HCP1302
Status: COMPLETED
Conditions: Erectile Dysfunction|Hypertension
Interventions: DRUG: HCP1302|DRUG: HGP0904|DRUG: Placebo (for HCP1302)|DRUG: Placebo (for HGP0904)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hemangioma Associated With High Rates of Morbidity
Status: COMPLETED
Conditions: Hemangioma
Interventions: DEVICE: MRI|DEVICE: MRI of head and neck|OTHER: Dermatological Examination|OTHER: Cardiac examination|DEVICE: Abdominal ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Spanish Mixed HEXA/PENTA/HEXA Schedule (V419-010)
Status: COMPLETED
Conditions: Neisseria Meningitidis|Bacterial Infections|Virus Diseases
Interventions: BIOLOGICAL: PR5I|BIOLOGICAL: Pediacel®|BIOLOGICAL: NeisVac-C®|BIOLOGICAL: RotaTeq®|BIOLOGICAL: Prevenar 13®
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: OsciPulse D-dimer Efficacy Trial
Status: WITHDRAWN
Conditions: Venous Thromboses|Ischemic Stroke
Interventions: DEVICE: OsciPulse system|DEVICE: Flowtron ACS900
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy and Safety of Retreatment With TAI for Patients Who Showed TACE-resistant: a Randomized Controlled Trial
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: TAI of FOLFOX|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Neoadjuvant Chemotherapy With and Without Zometa for Management of Locally Advanced Breast Cancers
Status: COMPLETED
Conditions: Locally Advanced Breast Cancer|Ductal Histologic Type|Without Her 2 Overexpression
Interventions: DRUG: Zometa + Neoadjuvant therapy|DRUG: Neoadjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined Lumbar Traction and Repetitive Back Extension Exercise on H-reflex in Lumbosacral Radiculopathy
Status: RECRUITING
Conditions: Lumbosacral Radiculopathy|McKenzie Derangement Syndrome
Interventions: OTHER: Repeated back extension exercise (McKenzie)|DEVICE: Mechanical traction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing a New Chemotherapy Drug, KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Patients With Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia|Secondary Acute Myeloid Leukemia
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Decitabine|DRUG: Navtemadlin|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Increased Absorption of a Curcumin Emulsion (CurQ+) in Healthy Volunteers
Status: COMPLETED
Conditions: Bioavailability
Interventions: DIETARY_SUPPLEMENT: 95% Curcuminoid Powder|DIETARY_SUPPLEMENT: CurQ+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Postmarketing Study of the Risk of Venous Thromboembolism (Blood Clots), Myocardial Infarction (Heart Attacks), and Stroke Among Women Using ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared With Women Who Take Oral Contraceptives for Birth Control
Status: COMPLETED
Conditions: Contraception|Female Contraception
Interventions: DRUG: Transdermal Contraceptive System|DRUG: Norgestimate-containing oral contraceptives with EE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Metagenomic Sequencing for the Identification of Pathogens in Febrile Neutropenic Patients
Status: RECRUITING
Conditions: Immunodepressed Patients (Hemato-oncology)
Interventions: DIAGNOSTIC_TEST: Metagenomic diagnosis (mNGS, DISQVER)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Status: RECRUITING
Conditions: Critical Illness|Acute Kidney Injury
Interventions: OTHER: Effluent dose of CRRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Effectiveness of Apixaban in Very Elderly Patients With Non-valvular Atrial Fibrillation (NVAF) Compared to Warfarin Using Administrative Claims Data
Status: COMPLETED
Conditions: Non-valvular Atrial Fibrillation
Interventions: DRUG: Warfarin|DRUG: Apixaban
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Teriflunomide on Immune Cell Subsets in the Blood of Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: teriflunomide HMR1726|DRUG: cholestyramine|DRUG: charcoal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Inflammatory Activation in Fat Tissue: an Atherogenic Factor in Stable Coronary Artery Disease
Status: COMPLETED
Conditions: Stable Coronary Artery Disease|Obesity|Impaired Glucose Tolerance
Interventions: OTHER: training|OTHER: training + metformin|OTHER: training + glitazon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TRAnscutaneous vaGUS Nerve Stimulation in Patients With Chronic Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction|Heart Failure With Midrange Ejection Fraction
Interventions: DEVICE: Active tVNS|DEVICE: Sham tVNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Multimodal Prehabilitation on Frail Elderly Patients Undergoing Elective Gastric Cancer Surgery
Status: COMPLETED
Conditions: Elderly|Frail|Gastric Cancer|Prehabilitation
Interventions: PROCEDURE: 3-week multimodal prehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mechanical Ventilation With and Without Postural Drainage in Burn Patients With ARDS
Status: COMPLETED
Conditions: Burns (Physical Finding)
Interventions: OTHER: Mechanical Ventilation|OTHER: Mechanical Ventilation with Postural drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CSL H1N1 Influenza Vaccine Administered at Two Dose Levels in Adult and Elderly Populations
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Inactivated H1N1 Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postoperative Pain of Root Canal Therapy With Three Techniques
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Instrumentation technique with hand file|PROCEDURE: Instrumentation technique with ProTaper|PROCEDURE: Instrumentation technique with WaveOne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Mild Neurocognitive Disorder|Thrombectomy
Interventions: PROCEDURE: Endovascular therapy|DRUG: Best medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Peripheral I.V. Catheter Complication Rates of Two Different Catheter Dressings
Status: TERMINATED
Conditions: Surgery
Interventions: DEVICE: New PIV Dressing|DEVICE: Standard PIV Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Abemaciclib in Participants With Cancer That is Advanced or Has Spread to Another Part(s) of the Body
Status: COMPLETED
Conditions: Neoplasm Metastasis
Interventions: DRUG: Drug Cocktail|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Genes Variability in Obesity and Normal Body Weight Patients.
Status: COMPLETED
Conditions: Obesity, Visceral|Obesity
Interventions: GENETIC: MT-ATP6 mtDNA gene variability in obesity and normal body weight patients.|GENETIC: SCD gene variability in obesity and normal body weight patients.|OTHER: Finding TOFI and FOTI phenotypes in participants with obesity and normal weight.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm
Status: RECRUITING
Conditions: Myelofibrosis|Essential Thrombocythemia|MPN
Interventions: DRUG: Peptide-based vaccine|DRUG: Poly ICLC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest
Status: RECRUITING
Conditions: Out of Hospital Cardiac Arrest Without ST-segment Elevation
Interventions: OTHER: Coronary Calcium Score and Coronary CT angiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Reduction of Perioperative Anxiety Using a Hand-held Video Game Device
Status: COMPLETED
Conditions: Separation Anxiety|Anxiety|Anxiety, Separation|Anxiety Generalized
Interventions: OTHER: Hand-held video game device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of MRG002 in Patients With HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer
Status: UNKNOWN
Conditions: Advanced Solid Tumors|Advanced or Metastatic Gastric Cancer|Advanced or Metastatic Gastroesophageal Junction Cancer
Interventions: DRUG: MRG002
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Anti-CTLA-4 Monoclonal Antibody Tremelimumab in Malignant Mesothelioma
Status: UNKNOWN
Conditions: Malignant Mesothelioma
Interventions: DRUG: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Amiloride and Spironolactone in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Spironolactone|DRUG: Amiloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Markers of Disease Progression and Gait Within the Parkinsonian Population
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: The FeetMe® Evaluation|DEVICE: the PKG® Watch,|RADIATION: MRI|RADIATION: DaTSCAN
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Relationship Between Different Doses of Propofol and the Occurrence of Dreams in Short Surgery Under General Anesthesia
Status: COMPLETED
Conditions: Dreaming|General Anesthesia
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Withdrawal of Inhaled Corticosteroids in Primary Care Patients With COPD
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: ICS withdrawal|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of an Early De-Escalation to a Low-potency Single Antiplatelet Therapy Guided by Genetics Versus a Systematic High-Potency Single Antiplatelet Therapy to Neutralize Bleeding Complications in Patients With High Bleeding Risk Beyond One Month After an Acute Coronary Syndrome
Status: RECRUITING
Conditions: MYOCARDIAL INFARCTION
Interventions: OTHER: single-antiplatelet with a low-potency antiplatelet (aspirin or clopidogrel) guided by genetic testing.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Prophylaxis of Thromboembolic Complications Trial: Thromboprophylaxis Needed in Below Knee Plaster Cast Immobilization for Ankle and Foot Fractures
Status: UNKNOWN
Conditions: Deep Vein Thrombosis|Pulmonary Embolism
Interventions: DRUG: Nadroparin|DRUG: Fondaparinux
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sugammadex Efficacy and Safety for Reversal of Pipecuronium-induced Neuromuscular Blockade
Status: UNKNOWN
Conditions: Adult Subjects Undergoing Abdominal Surgery Under General Anesthesia
Interventions: DRUG: sugammadex|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assess Safety, Tolerability and Pharmacokinetic (PK) of AZD1704 in Healthy Japanese Male and Non-Fertile Female Volunteers
Status: TERMINATED
Conditions: Healthy Volunteers
Interventions: DRUG: AZD1704|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Black Economic Equity Movement
Status: ACTIVE_NOT_RECRUITING
Conditions: Mental Health Wellness 1|Health Care Utilization|Financial Hardship|Education, Professional
Interventions: OTHER: Guaranteed Income|BEHAVIORAL: Peer learning circles|BEHAVIORAL: Financial coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PROton Therapy for Post Surgical Treatment of GYNecologic Cancer
Status: RECRUITING
Conditions: Cervical Cancer|Uterine Cancer|Endometrial Cancer
Interventions: RADIATION: Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT