pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Acupuncture to Treat Insulin Resistance in Women With and Without Polycystic Ovary Syndrome
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Insulin Resistance
Interventions: OTHER: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib in Combination With Camrelizumab as First-Line Therapy in Patients With Advanced HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DTI-guided Minimally Invasive Hematoma Evacuation for Intracerebral Hemorrhage
Status: RECRUITING
Conditions: Stroke Hemorrhagic
Interventions: PROCEDURE: Minimally Invasive Hematoma Evacuation|OTHER: Best Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Dissection|Aortic Aneurysm
Interventions: DEVICE: Open repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1/2, Randomized, Placebo-controlled, Observer-blinded Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Adults 18 To 49 Years Of Age
Status: COMPLETED
Conditions: Group B Streptococcal Infections
Interventions: BIOLOGICAL: Multivalent group B streptococcus vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams
Status: TERMINATED
Conditions: Dyspnea|Coma|Hypotension and Shock
Interventions: DIAGNOSTIC_TEST: ultrasound protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery
Status: WITHDRAWN
Conditions: Lumbar Disc Disease|Spinal Fusion|Degenerative Disc Disease
Interventions: DRUG: Propranolol Hcl 40mg Tab|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Multimedia HIV/STI Prevention for Drug-Involved Female Offenders
Status: COMPLETED
Conditions: HIV|Sexually Transmitted Infections
Interventions: BEHAVIORAL: Multimedia WORTH|BEHAVIORAL: Traditional WORTH|BEHAVIORAL: Wellness Promotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prevention of Phototoxicities in Patients Undergoing Vemurafenib Treatment
Status: COMPLETED
Conditions: Phototoxicity
Interventions: OTHER: Photoderm Max lait SPF50+|OTHER: Photoderm Max Stick SPF50+
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial of Neoadjuvant[FEC100]/Cisplatin-Docetaxel ± Trastuzumab in Women With Over Expressed or Amplified Her2/Neu With Locally Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: RADIATION: Cisplatin-Docetaxel ± Trastuzumab|OTHER: Cisplatin-Docetaxel ± Trastuzumab|DRUG: Cisplatin-Docetaxel ± Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Advanced Multiple Myeloma (0683-004)
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: MK0683, vorinostat, Suberoylanilide Hydroxamic Acid (SAHA) / Duration of Treatment - Up to 8 Cycles or 6 months
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of Applications of PillCam™ Endoscopy and Patency Systems and Clinical Evaluation of Their Performance in Healthy Volunteers ("HEIGHT" Study)
Status: TERMINATED
Conditions: Healthy
Interventions: DEVICE: PillCam™ Endoscopy System|DRUG: Bowel prep combination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pharmacokinetics Study of XG005 Capsule
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: XG005|DRUG: Combination of Naproxen and Pregabalin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia
Status: WITHDRAWN
Conditions: Trigeminal Neuralgia
Interventions: DRUG: Oxtellar XR 150Mg Extended Release Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica
Status: UNKNOWN
Conditions: RADICULAR PAIN
Interventions: DRUG: DEXAMETHASONE|OTHER: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Encouraging a Plant Based Diet in an Underserved Urban Population
Status: RECRUITING
Conditions: Food Neophobia|Food Preferences|Dietary Habits
Interventions: OTHER: Implementing free/subsidized agricultural produce to encourage a plant-based diet.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM)
Status: RECRUITING
Conditions: Cerebral Cavernous Malformation
Interventions: OTHER: Hyperventilation and CO2 challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: LEAP2 on Postprandial Glucose Metabolism and Food Intake
Status: COMPLETED
Conditions: Obesity
Interventions: BIOLOGICAL: Liver-enriched antimicrobial peptide 2|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extremely Low Gestatonal Age Infants' Paracetamol Study
Status: COMPLETED
Conditions: Prematurity; Extreme|Low Birthweight, Extremely (999 Grams or Less)
Interventions: DRUG: Paracetamol 10mg/mL infusion solution|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Propranolol as Compared to Bleomycin in Management of Hemangioma
Status: COMPLETED
Conditions: Hemangioma|Propranolol
Interventions: DRUG: Bleomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Administered Every 2 Weeks With or Without Pegfilgrastim in Subjects With Advanced or Metastatic Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer|Colorectal Cancer|Rectal Cancer
Interventions: DRUG: Placebo|DRUG: Pegfilgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gemcitabine+ Capecitabine Vs Capecitabine in Curatively Resected Biliary Tract Cancer
Status: RECRUITING
Conditions: Biliary Tract Cancer
Interventions: DRUG: Gemcitabine/Capecitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sevicontrol-1: Efficacy and Safety of a Fixed Combination of Olmesartan/ Amlodipine
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan cilexetil|DRUG: Olmesartan/Amlodipin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax Treatment (26 Cycles) With 6 Cycles or 12 Cycles of Epcoritamab in Patients With Relapsed or Refractory CLL or SLL
Status: RECRUITING
Conditions: CLL/SLL
Interventions: DRUG: Epcoritamab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Multigrain Supplementation Among the Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DIETARY_SUPPLEMENT: Multigrain powder (S)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multimodal Geriatric Pre-authorization Before Scheduled Orthopedic Surgery
Status: RECRUITING
Conditions: Osteoarthritis|Gonarthrosis
Interventions: BEHAVIORAL: Multimodal geriatric prehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Aprocitentan 5 mg|DRUG: Aprocitentan 10 mg|DRUG: Aprocitentan 25 mg|DRUG: Aprocitentan 50 mg|DRUG: Lisinopril 20 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Addition for Patients With Recent-onset Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychosis NOS
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate the Relative Bioavailability, Food Effect, and Dose Proportionality of a Granule Formulation of Vanzacaftor/Tezacaftor/Deutivacaftor(VNZ/TEZ/D-IVA)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VNZ/TEZ/D-IVA|DRUG: VNZ/TEZ/D-IVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis
Status: COMPLETED
Conditions: Chronic Apical Periodontitis
Interventions: DRUG: Calcipex II|DRUG: Metapex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of JT001 (VV116) Compared With Paxlovid
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: JT001|DRUG: Paxlovid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mitigation of Radiation Pneumonitis and Fibrosis
Status: COMPLETED
Conditions: Lung Cancer|Radiation Pneumonitis
Interventions: DRUG: Enalapril|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effect of Pneumatic Intermittent Venous Compression on Fluid Volumes Infused During Major Abdominal Surgery
Status: WITHDRAWN
Conditions: Major Abdominal Surgery
Interventions: DEVICE: Intermittent pneumatic compression|PROCEDURE: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: rhBNP|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Bowen's Disease|Superficial Basal Cell Carcinoma
Interventions: DEVICE: full ablative CO2 laser|DEVICE: fractional ablative CO2 laser|DRUG: MAL|DEVICE: LED lamp|DRUG: lidocaine hydrochloride 2% with epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Dementia and Delirium in Outpatient Clinics (DESTAN Trial)
Status: RECRUITING
Conditions: Delirium in Old Age|Delirium Superimposed on Dementia|Delirium With Dementia
Interventions: DIAGNOSTIC_TEST: Confussion assessment method (CAM)|DIAGNOSTIC_TEST: Dementia diagnosis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Role of Glutamine as Myocardial Protector in Elective On-Pump CABG Surgery With Low EF
Status: COMPLETED
Conditions: Coronary Artery Bypass|Cardiopulmonary Bypass|Coronary Artery Disease
Interventions: DRUG: L-alanyl-L-glutamine dipeptide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment
Status: COMPLETED
Conditions: Rhegmatogenous Retinal Detachment
Interventions: PROCEDURE: Vitrectomy|PROCEDURE: Pneumatic retinopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Fat and Theobromine on apoA-I
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Fat milkshake|DIETARY_SUPPLEMENT: Theobromine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lavender Aromatherapy Spine Procedure Study
Status: COMPLETED
Conditions: Spine Injuries and Disorders|Pain, Back
Interventions: OTHER: Activated Lavender Elequil aromatabs® (#372)|OTHER: Unactivated Lavender Elequil aromatabs® (#372)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study
Status: NOT_YET_RECRUITING
Conditions: Hematopoietic and Lymphatic System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Goal Setting|OTHER: Interview|OTHER: Interview|OTHER: Media Intervention|OTHER: Medical Device Usage and Evaluation|OTHER: Medical Device Usage and Evaluation|OTHER: Questionnaire Administration|OTHER: Reward|OTHER: Text Message-Based Navigation Intervention|OTHER: Text Message-Based Navigation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Food-grown Magnesium on Sleep Quality/Quantity
Status: COMPLETED
Conditions: Sleep
Interventions: DRUG: Food-Grown Magnesium|DRUG: Microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spironolactone for the Treatment of Melasma
Status: WITHDRAWN
Conditions: Melasma
Interventions: DRUG: Spironolactone 50Mg Tablet|DRUG: Spironolactone 100Mg Tablet|DRUG: Spironolactone 200Mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating an Online Mindfulness-Based Intervention for Insomnia
Status: UNKNOWN
Conditions: Insomnia, Primary
Interventions: BEHAVIORAL: 'Mindful Living With Insomnia (MLWI)' Intervention via WeChat mini-program|BEHAVIORAL: 'Cognitive Behavioral Therapy for insomnia (CBT-I)'via WeChat mini-program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep/Wake State Assessment With Non-invasive Earbuds
Status: RECRUITING
Conditions: Hypersomnolence
Interventions: DEVICE: NextSense EEG-enabled earbuds|DEVICE: Ellcie Healthy eyeglasses|OTHER: Drug Holiday
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Tissue-specific Responses to Influenza Immunization and Their Relation to Blood Biomarkers (SLVP032)
Status: TERMINATED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluzone®|BIOLOGICAL: FluMist®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre-emptive Opioid Treatment to Prevent Rebound Pain After Arthroscopic Rotator Cuff Repair and/or Acromioplasty Under General Anesthesia and Interscalene Block
Status: COMPLETED
Conditions: Rotator Cuff Injury|Pain
Interventions: DRUG: Hydromorphone Hcl 2Mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of a Dexmedetomidine on Quality of Recovery 40 and Postoperative Nausea and Vomiting in Breast Cancer Surgery
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Dexmedetomidine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Extended Steroid in Use in Community Acquired Pneumonia (CAP)(e)
Status: COMPLETED
Conditions: Community Acquired Respiratory Disease Syndrome
Interventions: DRUG: Inactive Substance|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Leningrado Association in the Treatment of Hypertension
Status: WITHDRAWN
Conditions: Arterial Hypertension
Interventions: DRUG: LENINGRADO association|DRUG: Indapamide SR 1.5 MG|DRUG: Levamlodipine 2.5/ 5 mg|OTHER: Leningrado association Placebo|OTHER: Indapamide SR Placebo|OTHER: Levamlodipine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Botulinum Toxin A in the Treatment of Bruxism-related Symptomatology
Status: TERMINATED
Conditions: Bruxism
Interventions: DRUG: Botulinum toxin injection|OTHER: QOL-Brux|OTHER: Muscular strength of the jaw|OTHER: Intensity and frequency of episodes of nocturnal bruxism|OTHER: visual analogue pain scale|OTHER: Endobuccal and linea alba photographs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CytoQuel: Clinical Documentation on Effects on Chronic Pain, Wellness, and Reduction of Inflammatory Markers
Status: COMPLETED
Conditions: Pain
Interventions: DIETARY_SUPPLEMENT: CytoQuel|DIETARY_SUPPLEMENT: CytoQuel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Bioequivalence Study of 2 Formulations of Rabeprazole Sodium and Evaluation of the Effect of Food on Rabeprazole Sodium in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rabeprazole sodium: Treatment A|DRUG: Rabeprazole sodium: Treatment B|DRUG: Rabeprazole sodium: Treatment C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Letrozole for Lymphangioleiomyomatosis
Status: COMPLETED
Conditions: Lymphangioleiomyomatosis
Interventions: DRUG: Letrozole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Small Steps Towards Improving Activity and Sleep Habits to Decrease the Risk of Dementia
Status: RECRUITING
Conditions: Dementia|Alzheimer Disease
Interventions: BEHAVIORAL: Small Steps Program|BEHAVIORAL: Comparator Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Motivational Therapy on Schizophrenia With Cannabis Misuse
Status: COMPLETED
Conditions: Schizophrenia|Cannabis Dependence, Continuous
Interventions: BEHAVIORAL: Motivational therapy|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery
Status: UNKNOWN
Conditions: Malignant Mesothelioma
Interventions: DRUG: chemotherapy|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma
Status: RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV
Interventions: DRUG: Binimetinib|DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Magnesium Supplementation on Hemodynamic Parameters and Cognitive Function
Status: COMPLETED
Conditions: Cognitive Function
Interventions: DIETARY_SUPPLEMENT: Magnesium Citrate|OTHER: Food grade citrate acid|OTHER: Splenda(Sucralose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Genetic Epidemiology Risk Assessment Program or Usual Care in Colorectal Cancer Screening for Healthy Participants
Status: COMPLETED
Conditions: Colorectal Cancer|Healthy, no Evidence of Disease
Interventions: OTHER: counseling intervention|OTHER: educational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dermal Profile Analysis Using the NMR-MOUSE
Status: TERMINATED
Conditions: Exposure to Magnetic Field|Hypotension During Dialysis|Disturbance; Balance, Fluid
Interventions: DEVICE: Dermal nuclear magnetic resonance (NMR)-profile measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: PROSAIC-19 - Prospective Longitudinal Assessment in a COVID-19 Infected Cohort
Status: UNKNOWN
Conditions: COVID-19|SARS-CoV 2|ARDS, Human|Immune System Disorder
Interventions: OTHER: Blood tests sputum, nasal lavage and brushing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PRenatal Video-Based Education and PostPARtum Effects
Status: ACTIVE_NOT_RECRUITING
Conditions: Breastfeeding
Interventions: BEHAVIORAL: AME|BEHAVIORAL: Video-based infant care education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Implementation Support for Prevention Program Delivery by College Peer Educators
Status: COMPLETED
Conditions: Eating Disorder
Interventions: BEHAVIORAL: Training|BEHAVIORAL: Training and Technical Assistance|BEHAVIORAL: Training, Tech. Assistance, Quality Assurance/Improvement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Preventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy
Status: RECRUITING
Conditions: Biliary Atresia|Cholangitis|Anti-Bacterial Agents
Interventions: DRUG: Basic treatment: sulperazone + ursodeoxycholic acid + compound glycyrrhizin + methylprednisolone + vitamin AD , D , E , K + imipenem or meropenem|DRUG: Prophylactic oral antibiotics: compound sulfamethoxazole tablet (SMZ/TMP) + cefaclor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Induction Chemotherapy (R-CHOP Vs. R-FC) Followed by Interferon Maintenance Versus Rituximab Maintenance in MCL
Status: UNKNOWN
Conditions: Lymphoma, Mantle-Cell
Interventions: DRUG: Rituximab|DRUG: Cyclophosphamide|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Prednisone|DRUG: Fludarabine|DRUG: Interferon-alpha|DRUG: pegylated formula Interferon-alpha 2b|PROCEDURE: chemotherapy: R-CHOP|PROCEDURE: chemotherapy: R-FC|PROCEDURE: Interferon maintenance|PROCEDURE: Rituximab maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of CART-19 Cells in Relapse and Refractory Patients With CD19+ B-cell Lymphoma
Status: UNKNOWN
Conditions: B Cell Lymphoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: CART-19
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Ointment on Epistaxis of Nasotracheal Intubation in Children
Status: COMPLETED
Conditions: Epistaxis|Intubation
Interventions: DRUG: tarivid ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pre-Exposure Prophylaxis Study of Lenacapavir and Emtricitabine/Tenofovir Alafenamide in Adolescent Girls and Young Women at Risk of HIV Infection
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre-Exposure Prophylaxis of HIV Infection
Interventions: DRUG: Oral Lenacapavir (LEN)|DRUG: Subcutaneous (SC) Lenacapavir (LEN)|DRUG: F/TAF|DRUG: F/TDF|DRUG: Placebo SC LEN|DRUG: PTM Oral LEN|DRUG: PTM F/TAF|DRUG: PTM F/TDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Bevacizumab, Doxorubicin, and Cyclophosphamide Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients Who Have Undergone Surgery for Early-Stage Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: bevacizumab|BIOLOGICAL: pegfilgrastim|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel albumin-stabilized nanoparticle formulation|OTHER: flow cytometry|OTHER: immunoenzyme technique|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|PROCEDURE: adjuvant therapy|PROCEDURE: immunoscintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study of Capecitabine in Combination With SIR-Spheres in Patients With Advanced Cancer
Status: COMPLETED
Conditions: Metastatic Liver Cancer
Interventions: RADIATION: SIRT|DRUG: capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies
Status: TERMINATED
Conditions: Colonoscopy
Interventions: DRUG: Low volume prep (Prepopik)|DRUG: Moderate volume prep (Moviprep)|DRUG: High volume prep (Golytely)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Epidural Anesthesia-analgesia and Long-term Survival After Lung Cancer Surgery
Status: COMPLETED
Conditions: Lung Cancer|Thoracic Surgery|Anesthesia, Epidural|Neoplasm Recurrence, Local|Neoplasm Metastasis
Interventions: DRUG: General anesthesia alone|DRUG: Combined epidural-general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tosedostat and Cytarabine or Azacitidine in Treating Older Participants With Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|High Risk Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|DRUG: Cytarabine|DRUG: Tosedostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustainable Preservation of Essential Oxygen Resources: A Phase 4 Crossover Study of the BUFEO System: SAVE O2
Status: COMPLETED
Conditions: Oxygen Deficiency|Oxygen Therapy
Interventions: DEVICE: BUFEO system|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients
Status: UNKNOWN
Conditions: Hyperlactatemia
Interventions: OTHER: Normal Saline|DRUG: Thiamine|DRUG: Hydrocortisone|OTHER: Metoclopramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of [18F] PBR06 and PET as a Marker of Inflammation in Subjects With Neurological Conditions
Status: TERMINATED
Conditions: Alzheimer Disease|Parkinson Disease|Multiple Sclerosis
Interventions: DRUG: [18F] PBR06
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioavailability Study of Metronidazole Capsules Under Fasting Conditions
Status: COMPLETED
Conditions: To Determine the Bioequivalence Study Under Fasting
Interventions: DRUG: Metronidazole|DRUG: Flagyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: High-Volume Image-Guided Injection in Chronic Midportion Achilles Tendinopathy
Status: COMPLETED
Conditions: Tendinopathy|Achilles Tendon Pain|Injection Site Fibrosis
Interventions: DRUG: HVIGI|DRUG: LVIGI|OTHER: Progressive exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients
Status: UNKNOWN
Conditions: COVID|Pulmonary Infection|Sars-CoV2
Interventions: DRUG: Oseltamivir|DRUG: Azithromycin|BIOLOGICAL: Umbilical Cord Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Care Training for Family Caregivers of Persons With Neurodegeneration
Status: RECRUITING
Conditions: Caregiver Burden|Caregiver Stress
Interventions: OTHER: Mindfulness Meditation|OTHER: Psychoeducation|OTHER: Wait list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: [18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson's Diseases and Essential Tremor
Status: RECRUITING
Conditions: Parkinson Disease|Essential Tremor
Interventions: DRUG: SPECT|DRUG: PET
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Implementation of Early Mobilization and Chest Physiotherapy on Weaning Rate of Prolong Weaning Patients.
Status: COMPLETED
Conditions: Prolonged Weaning, Early Mobilization, Chest Physiotherapy
Interventions: OTHER: Early mobilization plus chest physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Radiation Therapy With or Without Gefitinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Adenocarcinoma of the Lung|Bronchoalveolar Cell Lung Cancer|Large Cell Lung Cancer|Squamous Cell Lung Cancer|Stage IIIA Non-small Cell Lung Cancer|Stage IIIB Non-small Cell Lung Cancer
Interventions: DRUG: cisplatin|DRUG: docetaxel|DRUG: etoposide|DRUG: gefitinib|RADIATION: radiation therapy|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-world Evaluation of Prevalence of Ocular Adverse Events in Patients With Neovascular (Wet) Agerelated Macular Degeneration (AMD) Who Received Anti-VEGF Agents (IRIS Registry)
Status: COMPLETED
Conditions: Age-related Macular Degeneration (AMD)
Interventions: OTHER: Aflibercept|OTHER: Ranibizumab|OTHER: Bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Peginesatide Injection for the Maintenance of Anemia in Chronic Renal Failure Participants Who Are on Hemodialysis or Do Not Require Dialysis and Previously Treated With Darbepoetin Alfa.
Status: COMPLETED
Conditions: Anemia
Interventions: DRUG: Peginesatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Time Restricted Eating, Eating Behaviors, and Cardiometabolic Risk in Emerging Adult Women
Status: RECRUITING
Conditions: Time Restricted Eating|Eating Behavior|Diet, Healthy|Nutrition, Healthy
Interventions: BEHAVIORAL: Time restricted eating
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fentanyl Sublingual Spray for the Treatment of Acute Procedure-related Pain in a Monitored Setting
Status: WITHDRAWN
Conditions: Chronic Pain
Interventions: DRUG: Fentanyl Sublingual Spray (FSS)|DRUG: Placebo Sublingual Spray (PSS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Combination of YH003, YH001 and Pembrolizumab in Subjects With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: YH003|DRUG: YH001|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correct Endotracheal Tube Placement Using Topographical Landmarks
Status: UNKNOWN
Conditions: Intubation, Intratracheal|Anatomic Landmarks
Interventions: DEVICE: Topographical landmark technique of endotracheal tube placement|DEVICE: Intubation guide mark technique of endotracheal tube placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bifrontal and Bitemporal Electroconvulsive Therapy (ECT) in Treatment of Patients With Schizophrenia
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DEVICE: Bifrontal electroconvulsive therapy|DEVICE: Bitemporal electroconvulsive therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Noninvasive Brain Stimulation in Post-traumatic Stress Disorder
Status: UNKNOWN
Conditions: Post-traumatic Stress Disorder
Interventions: DEVICE: Active repetitive Transcranial Magnetic Stimulation|DEVICE: Sham repetitive Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Physiological Effects on the Skin of 3 Food Supplements Versus Placebo in 40-60 Years Old Female Subjects
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Botanicals extracts|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of the Efficacy and Safety of Pegol-Sihematide for Anemia in Patients With NDD-CKD
Status: UNKNOWN
Conditions: Non-Dialysis-Dependent Chronic Kidney Disease
Interventions: DRUG: Pegol-Sihematide|DRUG: ESPO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life During Treatment of Chronic Hepatitis C (P05278/MK-4031-336)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Genotype 1|HCV-1
Interventions: BIOLOGICAL: Peginterferon alfa-2b (PEG)|DRUG: Ribavirin (RBV)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study
Status: COMPLETED
Conditions: Chronic Aphasia
Interventions: DEVICE: HD-tDCS (Soterix Medical, Active)|DEVICE: HD-tDCS (Soterix Medical, Sham)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab With or Without Axitinib for Treatment of Locally Advanced or Metastatic Clear Cell Kidney Cancer in Patients Undergoing Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Clear Cell Renal Cell Carcinoma|Recurrent Clear Cell Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v8|Stage IV Renal Cell Cancer AJCC v8|Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Axitinib (VEGF-TKI)|PROCEDURE: Cytoreductive Nephrectomy (CN)|PROCEDURE: Metastasectomy (MET)|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Arm Clinical Trial of Small Molecule Natural Flavonoid Compounds for Intervention in Neurodegenerative Diseases
Status: NOT_YET_RECRUITING
Conditions: Neurodegenerative Diseases
Interventions: DRUG: SMARTO ONE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Pharmacology of EYP001 in HBV Subjects
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: EYP001a|DRUG: Placebo|DRUG: Entecavir|DRUG: peg-interferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Brain Injuries, Traumatic
Interventions: BEHAVIORAL: MI and CBT 4-session manualized intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Efficacy of Cyanoacrylate Adhesive (PeriAcryl®90 HV) in Periodontal Wound Healing
Status: UNKNOWN
Conditions: Periodontal Disease|Tissue Adhesive|Dental Scaling|Wound Healing|Oral Surgical Procedures|Pain
Interventions: DEVICE: PeriAcryl®90 HV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EXtending the tIme Window of Thrombolysis by ButyphThalide up to 6 Hours After Onset (EXIT-BT)
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: DRUG: TNK-Tissue Plasminogen Activator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Control Using Mobile-based Intervention in Patients With Diabetes Undergoing Coronary Artery Bypass to Promote Self-management
Status: COMPLETED
Conditions: Coronary Artery Disease|Coronary Artery Bypass|Diabetes Mellitus
Interventions: BEHAVIORAL: Smartphone Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Opioid and Pain Cognition
Status: COMPLETED
Conditions: Pain
Interventions: BEHAVIORAL: Cognitive bias modification|BEHAVIORAL: Standard attentional bias
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improving Rotavirus Vaccine Immune Response
Status: COMPLETED
Conditions: Healthy Infants|Mothers
Interventions: BIOLOGICAL: Rotavirus Vaccine & Breastfeeding|BIOLOGICAL: Rotavirus Vaccine & Breastfeeding|BIOLOGICAL: Rotavirus Vaccine & Breastfeeding|BIOLOGICAL: Rotavirus Vaccine & Breastfeeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Coagulation Profile and Haematopoietic Responses in Patients With Acute-on-chronic Liver Failure During Systemic Inflammatory Response (SIRS) and Sepsis
Status: COMPLETED
Conditions: Acute on Chronic Liver Failure
Interventions: OTHER: Sonoclot/TEG test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparative Effectiveness of School-based Caries Prevention
Status: COMPLETED
Conditions: Dental Caries|Quality of Life
Interventions: DEVICE: Silver Diamine Fluoride|DEVICE: Fluoride Varnishes|DEVICE: Glass Ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Influence of Hormone Replacement Therapy and Supervised Exercise Training on Body Composition, Cardiovascular Risk and Insulin Sensitivity in Postmenopausal Women
Status: RECRUITING
Conditions: Postmenopause
Interventions: OTHER: Exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LifeNet: Extracellular Matrix Graft in Rotator Cuff Repair
Status: ACTIVE_NOT_RECRUITING
Conditions: Rotator Cuff Tear
Interventions: BIOLOGICAL: ArthroFLEX ECM scaffold graft|PROCEDURE: Control|BIOLOGICAL: Crossover
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Health Outcomes With CPAP or NIV in Patients With COPD and a Sleep Related Breathing Disorder
Status: TERMINATED
Conditions: Chronic Obstructive Pulmonary Disease|Sleep Related Hypoventilation|Obstructive Sleep Apnea|Hypoventilation
Interventions: DEVICE: Positive airway pressure with continuous positive airway pressure or noninvasive ventilation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy Followed by Pelvic Reirradiation Versus Chemotherapy Alone as Pre-operative Treatment for Locally Recurrent Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Cancer
Interventions: DRUG: Chemotherapy FOLFIRINOX, 6 cycles|RADIATION: Radiochemotherapy|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NMES and Chronic Ankle Instability
Status: UNKNOWN
Conditions: Chronic Ankle Instability
Interventions: DEVICE: Neuromuscular Electrical Stimulation|DEVICE: Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Behavioral Intervention to Optimize Supplement Adherence in Ethiopia
Status: ENROLLING_BY_INVITATION
Conditions: Adherence, Patient
Interventions: BEHAVIORAL: Motivational materials for pregnant women attending antenatal care visits to improve supplement adherence|OTHER: Providers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension
Status: RECRUITING
Conditions: Resistant Hypertension
Interventions: DRUG: Baxdrostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)
Status: TERMINATED
Conditions: Stroke
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Acetylsalicylic acid (Aspirin, BAY1019036)|OTHER: Rivaroxaban-Placebo|OTHER: Aspirin-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION