pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns
Status: RECRUITING
Conditions: Premature Birth|Respiratory Distress Syndrome in Premature Infant|Sepsis|Intraventricular Hemorrhage of Prematurity|Bronchodysplasia|Jaundice
Interventions: OTHER: Physiological Based Cord Clamping|OTHER: Differed Cord Clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conversion to SADI-S, RYGB or OAGB After Failed Sleeve
Status: NOT_YET_RECRUITING
Conditions: Weight Loss|Bariatric Surgery Candidate|Comorbidities and Coexisting Conditions|Nutrient Deficiency
Interventions: PROCEDURE: revision surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double Blind, Parallel Group, Placebo Controlled, Multicenter Outpatient Trial Of PD 0200390 In Adults With Primary Insomnia
Status: COMPLETED
Conditions: Insomnia
Interventions: DRUG: PD 0200390|DRUG: PD 0200390|DRUG: PD 0200390|DRUG: PD 0200390|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimisation of Potential Dental Implant Sites Protection for Rehabilitation in Patients With Head and Neck Cancer: Impact of Virtual Implants Visualisation on Dosimetry (OPPIDOM)
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of Head and Neck|Oropharyngeal Squamous Cell Carcinoma|Oral Cavity Squamous Cell Carcinoma
Interventions: OTHER: Optimisation of dental implant sites protection from irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Tele-rehabilitation or Video-Based Core Exercises in Individuals With Axial Spondyloarthritis
Status: COMPLETED
Conditions: Axial Spondyloarthritis|Telerehabilitation|Exercise
Interventions: OTHER: Core Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis
Status: UNKNOWN
Conditions: Chorioretinitis
Interventions: PROCEDURE: Intravitreal injection|DIAGNOSTIC_TEST: Fluorescent angiography|DIAGNOSTIC_TEST: Visometry|DIAGNOSTIC_TEST: Refractometry|DIAGNOSTIC_TEST: Slit lamp examination|DIAGNOSTIC_TEST: Ophthalmoscopy|DIAGNOSTIC_TEST: OKT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Correlative Study of Biomarkers in Patients With Metastatic Renal Cell Carcinoma Who Have Progressed After Sunitinib Therapy
Status: WITHDRAWN
Conditions: Carcinoma, Renal Cell
Interventions: OTHER: Not applicable - blood tests/tissue specimen tests will be undertaken
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Folfox-B Study for Patients With Colorectal Liver Metastases
Status: TERMINATED
Conditions: Colorectal Liver Metastases
Interventions: DRUG: 5-Fluorouracil|DRUG: Bevacizumab|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GIP Receptor Antagonist Studies in Humans
Status: COMPLETED
Conditions: Glucose Metabolism
Interventions: DRUG: GIP-A|DRUG: GIP(1-42)|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Left Renal Vein Division for Juxtarenal Aortic Exposure
Status: UNKNOWN
Conditions: Aortic Aneurysm|Juxtarenal Aortic Aneurysm|Renal Function Disorder
Interventions: PROCEDURE: Exclusion of the aortic aneurysm.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.
Status: COMPLETED
Conditions: Chronic Constipation
Interventions: DRUG: PEG 4000 (Forlax®)|DRUG: Lactulose active and Lactulose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cannabidiol in Learning and Memory of Adults
Status: COMPLETED
Conditions: Memory
Interventions: DRUG: Cannabidiol in Oral Dose Form|DRUG: Placebo in Oral Dose Form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Stiripentol in Patients 6 Years and Older With Primary Hyperoxaluria Type 1, 2 or 3
Status: NOT_YET_RECRUITING
Conditions: Primary Hyperoxaluria Type 1|Primary Hyperoxaluria Type 2|Primary Hyperoxaluria Type 3
Interventions: DRUG: Stiripentol Oral Capsule|DRUG: Placebo Oral Capsule|BIOLOGICAL: Urine samples collect|BIOLOGICAL: Blood samples collect|OTHER: Kidney imaging|OTHER: Quality of Life questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PF-07260437 in Advanced or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Ovarian Neoplasms|Endometrial Neoplasms|Breast Neoplasms
Interventions: DRUG: PF-07260437|DIAGNOSTIC_TEST: B7-H4 IHC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Air Pollution (PM2.5) on Accelerated Atherosclerosis: A Montelukast Interventional Study in Modernizing China
Status: NOT_YET_RECRUITING
Conditions: Atherosclerosis, Coronary
Interventions: DRUG: Montelukast Oral Tablet|DRUG: Montelukast Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Post Market Study of the 3DKnee™ With E-plus Insert
Status: TERMINATED
Conditions: Degenerative Joint Disease|Osteoarthritis|Traumatic Arthritis
Interventions: DEVICE: 3DKnee™ System with Vitamin E UHMWPE Tibial Inserts
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1/2, First-in-Human, Open Label, Dose Escalation Study Of A CSP Targeting Functional Antibody in Solid Tumors
Status: COMPLETED
Conditions: Solid Tumor, Adult|Pancreatic Ductal; Adenocarcinoma|Ovarian Serous Adenocarcinoma|Biliary Cancer Metastatic|Ovarian Serous Cystadenocarcinoma
Interventions: DRUG: ZB131
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dormia Basket Versus Extraction Ballon in Proximally Migrated Biliary Stents
Status: COMPLETED
Conditions: Biliary Obstruction
Interventions: DEVICE: dormia basket|DEVICE: Extraction biliary ballon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Clinical Trial of Single-Vial ID93 + GLA-SE in Healthy Adults
Status: COMPLETED
Conditions: Pulmonary TB
Interventions: BIOLOGICAL: ID93 + GLA-SE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
Status: RECRUITING
Conditions: Rectal Adenocarcinoma|Clinical Stage: Stage II (T3-4, N-)|Stage III (Any T, N+)|Solid Tumor|Solid Tumor, Adult
Interventions: DRUG: TSR-042 or Dostarlimab|DRUG: capecitabine or 5-FU|RADIATION: Intensity Modulated Radiation Therapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Dose Cefepime Versus Cefuroxime Plus Metronidazole as a Prophylactic Antibiotic During Emergency Intrapartum Cesarean Section
Status: UNKNOWN
Conditions: Emergency Cesarean Section|Infection Wound
Interventions: DRUG: Cefepime|DRUG: Cefuroxime plus Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cost-Effectiveness of Web-Based Follow Ups
Status: COMPLETED
Conditions: Osteoarthritis in the Knee Joint|Osteoarthritis in the Hip Joint
Interventions: OTHER: in-person|OTHER: web-based
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Entecavir Plus Tenofovir Combination Therapy Versus Entecavir Monotherapy in Naive Subjects With Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Entecavir + Tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Status: COMPLETED
Conditions: Anesthesia|Deep Sedation
Interventions: DEVICE: qCON-qNOX|DEVICE: BIS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Patient Controlled Epidural (PCEA)|DRUG: Local Infiltration Analgesia (LIA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Effect of Vagal Nerve Stimulator (VNS) on Electrocorticograms Recorded by Responsive Neurostimulator (RNS) in Patients With Drug Resistant Epilepsy
Status: WITHDRAWN
Conditions: Epilepsy
Interventions: OTHER: observation of VNS stimulation effects
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Misoprostol for Treatment of Postpartum Hemorrhage at Community-level Births in Egypt
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: OTHER: Misoprostol + referral|OTHER: Placebo + referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Triamcinolone Acetonide on the Growth Velocity of Children, Ages 3 to 9, With Perennial Allergic Rhinitis (PAR)
Status: COMPLETED
Conditions: Rhinitis, Allergic, Perennial
Interventions: OTHER: Placebo|OTHER: Placebo|DRUG: TAA-AQ, Nasacort® AQ|DRUG: Claritin®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HEADS: UP Online Psychological Self-management Intervention: Feasibility 2
Status: COMPLETED
Conditions: Stroke|CVA (Cerebrovascular Accident)|Anxiety|Depression
Interventions: BEHAVIORAL: Helping Ease Anxiety and Depression following Stroke
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Conjunctival Flora Patterns After Serial Intravitreal Injections in Diabetic Patients
Status: UNKNOWN
Conditions: Diabetic Retinopathy|Diabetic Macular Edema
Interventions: DRUG: povidone-iodine 4%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cisplatin, Vinorelbine, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Control arm (SEQ):|DRUG: Experimental arm (CON):
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accelerated Pulmonary Rehabilitation in the Preoperative Period
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease|Lung Cancer Stage I|Lung Cancer Stage II|Lung Cancer Stage III
Interventions: OTHER: Pulmonary Rehab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Duration of Olanzapine Add-on Therapy in Major Depression
Status: WITHDRAWN
Conditions: Relapse Rate of a Major Depressive Episode|Safety of Olanzapine in Subjects With Major Depression
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glofitamab in Relapsed or Refractory Diffuse Large B-cell Lymphoma After CD19 Chimeric Antigen Receptor T-cell Therapy
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B Cell Lymphoma
Interventions: DRUG: Glofitamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Reverse Nordic Curl Exercise on Quadriceps Femoris Muscles Injury Rate Among Soccer Players
Status: UNKNOWN
Conditions: Quadriceps Tendon Rupture|Quadriceps Strained Tendon|Quadriceps Muscle Atrophy
Interventions: OTHER: Reverse Nordic curl exercise|OTHER: Usual warm up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mini-Dose Glucagon to Treat Fasting-induced Hypoglycemia During Ramadan
Status: COMPLETED
Conditions: Fasting Hypoglycemia|Diabetes Mellitus, Type 1
Interventions: DRUG: Glucagon Injection|OTHER: Glucose Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stellate Ganglion Block to Reduce Hot Flushes
Status: COMPLETED
Conditions: Hot Flash|Stellate Ganglion Block|Postmenopausal|Hot Flushes
Interventions: PROCEDURE: Bupivacaine block|PROCEDURE: Placebo ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Muscle Training in Institutionalized Elderly Population
Status: COMPLETED
Conditions: Muscle Weakness|Syndrome; Institutionalization|Other Diagnoses, Comorbidities, and Complications
Interventions: DEVICE: Threshold® Inspiratory Muscle Trainer (Respironics® Health Scan Inc. Cedar Grove, NJ, USA).|OTHER: Yoga Pranayama breathing exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab for the Treatment of Relapsed or Refractory Multiple Myeloma After Anti-BCMA CAR-T Therapies
Status: TERMINATED
Conditions: Multiple Myeloma|Multiple Myeloma in Relapse|Multiple Myeloma, Refractory|Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Study to Assess the Efficacy and Safety of GV1001-Gem/Cap vs Gem/Cap in Pancreatic Cancer Patients
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: GV1001|DRUG: Gemcitabine|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy
Status: TERMINATED
Conditions: Maternal Psychological Distress|Postpartum Depression|Prenatal Stress
Interventions: BEHAVIORAL: Mindfulness Based Cognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients
Status: COMPLETED
Conditions: Hidradenitis Suppurativa (Acne Inversa)
Interventions: BIOLOGICAL: CJM112|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cardea SOLOTM for Paroxysmal Atrial Fibrillation Diagnosis in ESUS Patients With Left Atrial Enlargement
Status: RECRUITING
Conditions: Embolic Stroke of Undetermined Source
Interventions: DEVICE: Cardea SOLO|DEVICE: 12 Lead EKG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of a Multi-disciplinary Approach for the Treatment of Hepatitis C in IDUs (HI-LO Study)
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: Interferon injections and ribavirin|DRUG: Interferon injections and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M7824 and Eribulin Mesylate in Treating Patients With Metastatic Triple Negative Breast Cancer
Status: TERMINATED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Triple-Negative Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: DRUG: Bintrafusp Alfa|DRUG: Eribulin Mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacotherapy of Psychotic Depression
Status: COMPLETED
Conditions: Major Depressive Disorder With Psychotic Features
Interventions: DRUG: Olanzapine|DRUG: Sertraline|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeated EUS-guided Fine Needle Biopsy of Pancreatic Masses After Non-diagnostic or Inconclusive Results
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Pancreas Cancer|Pancreas Metastases
Interventions: DIAGNOSTIC_TEST: endoscopic ultrasound-guided fine needle biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Precision Medicine for Every Child With Cancer
Status: RECRUITING
Conditions: Childhood Cancer|Childhood Solid Tumor|Childhood Brain Tumor|Childhood Leukemia|Refractory Cancer|Relapsed Cancer
Interventions: GENETIC: Whole Genome Sequencing|GENETIC: RNA seq|GENETIC: DNA Methylation|GENETIC: Targeted Panel Sequencing|GENETIC: High Throughput Sequencing (in vitro)|GENETIC: Patient Derived Xenograft (PDX)(in vivo)|OTHER: Liquid Biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single and Multiple Oral Doses of Dabigatran Etexilate in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dabigatran etexilate low|DRUG: Dabigatran etexilate high
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychological Treatment of Overweight Binge Eaters
Status: COMPLETED
Conditions: Binge Eating Disorder|Cognitive Therapy/Methods|Mental Disorders/Epidemiology|Obesity/Epidemiology|Obesity/Therapy
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy (CBT)|BEHAVIORAL: Interpersonal Therapy (IPT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: SMLI With Hispanic Cancer Survivors and Caregivers
Status: RECRUITING
Conditions: Cancer Survivors|Cancer
Interventions: BEHAVIORAL: Symptom assessment only|BEHAVIORAL: Symptom management and lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biosimilarity Study of Subcutaneous Filgrastim in Healthy Volunteers
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: BIOLOGICAL: Filgrastim Megalabs|BIOLOGICAL: Granulokine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa (AURORA)
Status: COMPLETED
Conditions: Hidradenitis Suppurativa|Acne Inversa
Interventions: DRUG: Avacopan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of TQ-B3139 in Subjects With Anaplastic Lymphoma Kinase (ALK) Positive Non-Small Cell Lung Cancer (NSCLC) Previously Treated With Crizotinib
Status: UNKNOWN
Conditions: ALK-positive NSCLC
Interventions: DRUG: TQ-B3139
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trachoma Amelioration in Northern Amhara (TANA)
Status: COMPLETED
Conditions: Trachoma|Chlamydia
Interventions: DRUG: Mass treatment with oral azithromycin to an entire community
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms
Interventions: DRUG: VIP152 (BAY 1251152)|DRUG: VIP152 (BAY 1251152) 30 mg|DRUG: Keytruda|DRUG: VIP152 (BAY 1251152) 15 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy
Status: UNKNOWN
Conditions: Terlipressin Adverse Reaction|Ascites Hepatic|Liver Failure|Acute Kidney Injury
Interventions: DRUG: Terlipressin plus standard care|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy for Children With CLN3 Batten Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: CLN3|Batten Disease
Interventions: GENETIC: Low dose AT-GTX-502|GENETIC: High dose AT-GTX-502
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MGR001 / Advair Diskus Local Equivalence Study in Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: MGR001 (Fixed dose combination of Fluticasone propionate and salmeterol xinafoate)|DRUG: Advair (Fixed dose combination of Fluticasone propionate and salmeterol xinafoate)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Two Monofocal, Aspheric, Hydrophobic Acrylic Intraocular Lenses: the Alcon CLAREON® and the Abbott Medical Optics PCB00
Status: COMPLETED
Conditions: Cataract Extraction|Phacoemulsification|Glistenings|Intraocular Lens Implant|Hydrophobic Acrylic|Cataract Surgery|Light Scatter|Patient Satisfaction|Patient Related Outcome Measures
Interventions: DEVICE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neostigmine Versus Dexamethasone as Adjuvants to Lidocaine During Intravenous Local Anesthesia
Status: COMPLETED
Conditions: Adjuvants, Anesthesia
Interventions: DRUG: Neostigmine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Influenza A/H1N1 Split- Virion Vaccine in Healthy Population Aged 3 Years and Older
Status: COMPLETED
Conditions: Virus Diseases|Respiratory Tract Diseases|Respiratory Tract Infections|Influenza|Orthomyxoviridae Infections
Interventions: BIOLOGICAL: split-virion, non-adjuvanted H1N1 vaccine of 30 μg|BIOLOGICAL: Experimental: split-virion, adjuvanted H1N1 vaccine of 7.5 μg|BIOLOGICAL: Experimental: split-virion, adjuvanted H1N1 vaccine of 15 μg|BIOLOGICAL: Experimental: split-virion, adjuvanted H1N1 vaccine of 30 μg|BIOLOGICAL: Experimental: split-virion, non-adjuvanted H1N1 vaccine of 15 μg|BIOLOGICAL: Placebo Comparator: Placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis
Status: NOT_YET_RECRUITING
Conditions: Tuberculosis|Tubercular Meningitis|Arachnoiditis; Tuberculous (Etiology)
Interventions: DRUG: Cyclophosphamide injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Bupropion for Treating Nicotine Dependence in Young People
Status: COMPLETED
Conditions: Tobacco Use Cessation|Tobacco Use Disorder
Interventions: DRUG: Bupropion-SR|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Therapeutic Exercises Delivered by Smartphone Application
Status: UNKNOWN
Conditions: Urinary Incontinence
Interventions: OTHER: Smartphone application|OTHER: Sham Smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prospective, Single Blind, Rand Controlled Study to Evaluate the Safety & Effectness of Tryton Side Branch Stent Used With DES Treatmt of de Novo Bifurcation Lesions in MB & SB in Native Coronaries
Status: COMPLETED
Conditions: Coronary Atherosclerosis of Native Coronary Artery|Bifurcation Lesions: de Novo Lesions of the Main and Side Branch of Native Coronary Artery
Interventions: DEVICE: Tryton Side Branch Stent with main branch DES|DEVICE: POBA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: COMET2 Project 1 Filter Ventilation Study
Status: COMPLETED
Conditions: Smoking|Tobacco Use
Interventions: OTHER: Ventilated cigarettes only|OTHER: Unventilated cigarettes only|OTHER: Access to Experimental Marketplace: Ventilated cigarettes + alternative nicotine delivery systems|OTHER: Access to Experimental Marketplace: Unventilated cigarettes + ANDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pasireotide, Everolimus and Selective Internal Radioembolization Therapy for Unresectable Hepatic Metastases
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Pasireotide|PROCEDURE: Sir-sphere Radioembolization|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-therapeutic MRI Assessment of Early Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery: A New Approach to the Management of Early Stage Rectal Cancer.
Status: NOT_YET_RECRUITING
Conditions: Rectal Cancer
Interventions: OTHER: Surveillance 6 monthly|OTHER: Radiotherapy and surveillance|OTHER: surveillance 3 montly
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Combined Medication and Behavioral Treatment for ASD & ADHD
Status: TERMINATED
Conditions: Autism Spectrum Disorder|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Amphetamine|BEHAVIORAL: ESDM informed parent coaching|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: OTHER: specific MRI Acquisition (NMR spectroscopy) at 7T
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Regional Cryotherapy in Preventing Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DEVICE: Elasto-Gel™|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in Human Immunodeficiency Virus (HIV)-1 Infected, Treatment-naive Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Elvucitabine|DRUG: Lamivudine|DRUG: Tenofovir|DRUG: Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The CONTRoL Trial: Cryotherapy vs. cOmpression Neuropathy TRiaL
Status: COMPLETED
Conditions: CIPN - Chemotherapy-Induced Peripheral Neuropathy
Interventions: DEVICE: Cryotherapy|DEVICE: Compression Therapy|DEVICE: Loose glove/sock
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: FX006 32 mg|DRUG: Placebo|DRUG: FX006 16 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria)
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Metastatic Malignant Neoplasm in the Spine
Interventions: OTHER: Immunotherapy|RADIATION: Stereotactic Radiosurgery|PROCEDURE: Vertebroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Elbow Hemiarthroplasty Versus ORIF for Distal Humeral Fractures
Status: RECRUITING
Conditions: Distal Humerus Fracture|Comminuted Fracture|Intra-Articular Fractures
Interventions: PROCEDURE: Surgical treatment of distal humeral fracture with elbow hemiarthroplasty|PROCEDURE: Surgical treatment of distal humeral fracture with double plating.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: External Beam Radiation With Intratumoral Injection of Dendritic Cells As Neo-Adjuvant Treatment for Sarcoma
Status: COMPLETED
Conditions: Soft Tissue Sarcoma
Interventions: BIOLOGICAL: Dendritic Cell (DC) Injections|PROCEDURE: Radiation therapy|PROCEDURE: Complete Resection - Surgery for tumor removal
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK/PD Investigation of Modufolin (Arfolitixorin) in Plasma, Tumor and Adjacent Mucosa Adjacent Mucosa in Patients With Colon Cancer
Status: COMPLETED
Conditions: Colonic Neoplasms
Interventions: DRUG: 6R-MTHF (arfolitixorin) 200 mg/m2|DRUG: Levoleucovorin 200 mg/m2|DRUG: 6R-MTHF (arfolitixorin) 60 mg/m2|DRUG: Levoleucovorin 60 mg/m2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study To Assess The Pharmacokinetics Of SB-742457 Formulated As A Capsule And A Tablet In Healthy Elderly Volunteers.
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: SB-742457
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
Status: COMPLETED
Conditions: Primary Immune Thrombocytopenia
Interventions: BIOLOGICAL: Efgartigimod PH20 SC|OTHER: Placebo PH20 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of GSK Biologicals' 2189242A Vaccine on Nasopharyngeal Carriage, Safety & Immunogenicity in Children & Infants
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: BIOLOGICAL: Pneumococcal vaccine GSK 2189242A (LD formulation 1)|BIOLOGICAL: Pneumococcal vaccine GSK 2189242A (HD formulation 2)|BIOLOGICAL: Synflorix™|BIOLOGICAL: Prevnar13™|BIOLOGICAL: Tritanrix™-HepB/Hib|BIOLOGICAL: Polio Sabin™|BIOLOGICAL: M-Vac™|BIOLOGICAL: Stamaril™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial on a Food Supplement With Melatonin and Herbal Products to Improve Sleep Quality
Status: RECRUITING
Conditions: Sleep Disorders
Interventions: DIETARY_SUPPLEMENT: Aquilea Sueno Forte|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Education, Medication Adjustment and Telemonitoring in Reducing Diabetes Complications During Ramadan
Status: COMPLETED
Conditions: Diabetes Mellitus|Fasting|Diabetes Complications
Interventions: COMBINATION_PRODUCT: Focused education, medication adjustment and telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SPIRIT V: Post-marketing Evaluation of the XIENCE V® Everolimus Eluting Coronary Stent System in Europe
Status: COMPLETED
Conditions: Coronary Disease|Coronary Artery Disease|Coronary Restenosis
Interventions: DEVICE: XIENCE V® Everolimus Eluting Coronary Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Assessment of Cardiac Output and Fluid Responsiveness in Bariatric Surgery
Status: COMPLETED
Conditions: Bariatric Surgery|Hemodynamics
Interventions: PROCEDURE: baseline alert 1|PROCEDURE: Anti-Trendelenburg-position (ATB)|PROCEDURE: ATB in narcosis|PROCEDURE: baseline in narcosis 1|PROCEDURE: passive leg raising|PROCEDURE: volume bolus substitution|PROCEDURE: baseline in narcosis 2|PROCEDURE: start capnoperitoneum|PROCEDURE: ATB plus capnoperitoneum|PROCEDURE: ATB plus capnoperitoneum plus volume bolus substitution|PROCEDURE: ATB loss of capnoperitoneum|PROCEDURE: baseline|PROCEDURE: baseline alert 2|PROCEDURE: torso position rising 30° at the beginning|PROCEDURE: torso position rising 30° at the end
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare ETC vs. EC-TX and Ibandronate vs. Observation in Patients With Node-positive Primary Breast Cancer (GAIN)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Epirubicine|DRUG: Cyclophosphamide|DRUG: Taxol|DRUG: Xeloda|DRUG: Ibandronat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photochemical Tissue Passivation Treatment of Saphenous Vein Grafts in CABG
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DEVICE: DurVena Photochemical Tissue Passivation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KL-A167 Injection Combined With Cisplatin and Gemcitabine vs Placebo Combined With Cisplatin and Gemcitabine in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Nasopharyngeal Carcinoma|Recurrent or Metastatic
Interventions: DRUG: KL-A167|DRUG: Gemcitabine|DRUG: Cisplatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy
Status: COMPLETED
Conditions: Adult Acute Megakaryoblastic Leukemia (M7)|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Monoblastic Leukemia (M5a)|Adult Acute Monocytic Leukemia (M5b)|Adult Acute Myeloblastic Leukemia With Maturation (M2)|Adult Acute Myeloblastic Leukemia Without Maturation (M1)|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Myelomonocytic Leukemia (M4)|Adult Erythroleukemia (M6a)|Adult Pure Erythroid Leukemia (M6b)|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Myeloid Leukemia
Interventions: PROCEDURE: standard follow-up care|OTHER: medical chart review|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: MDMA|BEHAVIORAL: CBCT|BEHAVIORAL: Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Surveillance Exercise Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Localized Prostate Cancer|Active Surveillance for Prostate Cancer
Interventions: BEHAVIORAL: Exercise|OTHER: Cardiopulmonary Exercise Test (CPET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation
Status: COMPLETED
Conditions: Acute Ischemic Stroke|Intracranial Artery Occlusion|Endovascular Thrombectomy
Interventions: DRUG: Tenecteplase|OTHER: endovascular thrombectomy alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S095033 in Combination With Paclitaxel as 2nd- or 3rd-line Treatment in Participants With Advanced or Metastatic ESCC
Status: WITHDRAWN
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Combination (S095033 + paclitaxel)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy, Stereotactic Body Radiation Therapy & Nelfinavir Mesylate in Locally Advanced Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Resectable Pancreatic Carcinoma|Stage I Pancreatic Cancer|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage II Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer
Interventions: PROCEDURE: 4-Dimensional Computed Tomography|DRUG: Fluorouracil|DRUG: Gemcitabine Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Nelfinavir Mesylate|BIOLOGICAL: Oregovomab|RADIATION: Stereotactic Body Radiation Therapy|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Efficacy of Fidaxomicin (Oral Suspension or Tablets) and Vancomycin (Oral Liquid or Capsules) in Pediatric Subjects With Clostridium Difficile-associated Diarrhea (CDAD)
Status: COMPLETED
Conditions: Clostridium Difficile-associated Diarrhea (CDAD)
Interventions: DRUG: Fidaxomicin oral suspension|DRUG: Fidaxomicin tablets|DRUG: Vancomycin oral liquid|DRUG: Vancomycin capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: Belatacept|DRUG: Tacrolimus|DRUG: Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Generation Drug Eluting Stent for In-stent Restenosis of Drug Eluting Stent( RESTENT-ISR Trial )
Status: UNKNOWN
Conditions: In-stent Arterial Restenosis
Interventions: DEVICE: Xiene V stent, Endeavor Resolute stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women
Status: COMPLETED
Conditions: Atherosclerosis|Diabetes Mellitus|Obesity|Dyslipidemia|Hypertension
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Weight Loss
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway
Status: COMPLETED
Conditions: Precedex Effect to Propofol Requirement
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Ascending Dose Study of the Safety and Tolerability of REGN727 (SAR236553) in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: REGN727|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock
Status: NOT_YET_RECRUITING
Conditions: Acute on Chronic Liver Failure
Interventions: DRUG: Terlipressin|DRUG: Norephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate PBR PET in Brain Tumor Patients Treated With Chemoradiation or Immunotherapy
Status: COMPLETED
Conditions: Intracranial Tumors|Glioblastoma|Melanoma
Interventions: OTHER: PBR PET|BIOLOGICAL: Cancer Immunotherapy|RADIATION: Radiation and chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of a Long Term, High Intensity and Long Time Stretch Training Program on Viscoelasticity Plantarflexors Muscle in Children With Cerebral Palsy (CP).
Status: TERMINATED
Conditions: Cerebral Palsy, Spastic|Children, Only
Interventions: DIAGNOSTIC_TEST: isokinetic dynamometer with ultrasound|OTHER: Visual Analog Scale (VAS)|DIAGNOSTIC_TEST: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition
Status: COMPLETED
Conditions: Cardiac Surgical Procedures|Thoracic Surgical Procedures|Sternotomy
Interventions: PROCEDURE: Valsalva maneuver|OTHER: Fluid loading
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: BIOLOGICAL: Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143|DRUG: Cyclophosphamide|DRUG: Fludarabine|PROCEDURE: Leukapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Laryngoscopy View Using Miller and Macintosh Laryngoscopy Blades in Infants Under Two Years of Age
Status: COMPLETED
Conditions: Percent of Glottic Opening
Interventions: DEVICE: Laryngoscope blade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Cultural Competence Education for Nurse Mentors
Status: COMPLETED
Conditions: Cultural Competency|Mentoring
Interventions: OTHER: Cultural Competence Education|OTHER: Standard Mentoring Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH