pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: EF5 to Evaluate Tumor Hypoxia in Patients With High-Grade Soft Tissue Sarcoma or Mouth Cancer
Status: TERMINATED
Conditions: Stage I Adult Soft Tissue Sarcoma|Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage II Adult Soft Tissue Sarcoma|Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity|Stage III Adult Soft Tissue Sarcoma|Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity
Interventions: DRUG: EF5|OTHER: diagnostic laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor
Status: COMPLETED
Conditions: Untreated Childhood Medulloblastoma|Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor
Interventions: DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: vincristine sulfate|DRUG: etoposide|PROCEDURE: therapeutic conventional surgery|RADIATION: 3-dimensional conformal radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Busulfan, Melphalan, and Antithymocyte Globulin Followed By Umbilical Cord Blood Transplant in Treating Young Patients With Refractory or Relapsed Malignant Solid Tumors
Status: UNKNOWN
Conditions: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: anti-thymocyte globulin|BIOLOGICAL: graft-versus-tumor induction therapy|BIOLOGICAL: sargramostim|DRUG: busulfan|DRUG: cyclosporine|DRUG: melphalan|DRUG: methylprednisolone|OTHER: flow cytometry|OTHER: immunologic technique|OTHER: laboratory biomarker analysis|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: umbilical cord blood transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Project to Study Probiotic Beauty Products on Skin Improvement
Status: COMPLETED
Conditions: Skin Diseases
Interventions: DIETARY_SUPPLEMENT: TAC/Collagen gel|DIETARY_SUPPLEMENT: placebo lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Biphasic Insulin Aspart 70/30 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of an Oral Medication in the Treatment and Prevention of Digital Ulcers in Patients With Systemic Sclerosis (Scleroderma).
Status: COMPLETED
Conditions: n Ulcer|Scleroderma, Systemic
Interventions: DRUG: Ambrisentan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of GATE-251 in Normal Human Volunteers
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: GATE-251|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of a Vancomycin Nomogram With a Continuous Infusion of Vancomycin for Surgical ICU Patients
Status: TERMINATED
Conditions: MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Interventions: DRUG: Vancomycin continuous infusion|DRUG: Vancomycin intermittent dosing interval
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimize the Support of Patients in Pelvic Onco-gynecology Through Adapted Support Care in the Post-cancer Period. AFTERGYN Pilot Phase
Status: RECRUITING
Conditions: Long Term Cancer Side Effects|Supportive Care in Cancer|Cancer Survivorship Care Plan|Advanced Nurse Practitioner|Pelvic Gynecological Cancer
Interventions: OTHER: Day hospitalization in support care with meeting with support care professionals and coordination of actions by the advanced practice nurse|OTHER: Delivery of useful information according to support care needs, concerning support care professionals in the city|OTHER: Delivery of a personalized post-cancer plan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Implementation Strategies for Monitoring Adherence in Real Time
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer|Medication Adherence|Symptoms and Signs
Interventions: DEVICE: Conversational Agent/Chatbot|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Diagnostic Innovations for Pediatric Tuberculosis in Bolivia
Status: RECRUITING
Conditions: Tuberculosis
Interventions: DIAGNOSTIC_TEST: Quantiferon Gold|DIAGNOSTIC_TEST: HIV serology|DIAGNOSTIC_TEST: Respiratory secretion culture (sputum or gastric aspirate_|DIAGNOSTIC_TEST: Chest radiograph|DIAGNOSTIC_TEST: Lung ultrasound|DIAGNOSTIC_TEST: cell free DNA test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Probiotics in Newly Diagnosed T1D
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes|Type1diabetes|Type 1 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Visbiome|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Treating Metabolic Acidosis in Chronic Kidney Disease to Prevent Adverse Kidney and Cardiovascular Outcomes
Status: COMPLETED
Conditions: Chronic Kidney Diseases|Cardiovascular Diseases|Hypertension
Interventions: OTHER: Fruits and Vegetables (F+V)|OTHER: Sodium Bicarbonate (NaHCO3)|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ghrelin and Beta Cell Function in Diabetes
Status: WITHDRAWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Synthetic human AG|DRUG: Arginine|DRUG: 0.9% saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Human Milk Oligosaccharides in Children With Type 1 Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetes Mellitus|Type1diabetes
Interventions: DIETARY_SUPPLEMENT: 2-fucosyllactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: LMA Unique TM & the Self Pressurized Air-Q TM Intubating Laryngeal Airway in Children
Status: COMPLETED
Conditions: Children
Interventions: DEVICE: Laryngeal Mask Airway|DEVICE: air-QTM Intubating Laryngeal Airway
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Randomized Trial Between Needle Fasciotomy and Xiapex for Dupuytrens Contracture
Status: UNKNOWN
Conditions: Dupuytrens Contracture
Interventions: DRUG: xiapex|PROCEDURE: percutaneous needle fasciotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Applicability of Tissue Flossing for Blood Flow Restriction in the Upper Limb: Reliability and Performance Analysis
Status: NOT_YET_RECRUITING
Conditions: Hypertrophy|Muscle Strength
Interventions: DEVICE: Tissue Flossing|DEVICE: Blood Flow Restriction Cuff|OTHER: Training Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Determine if Mesh Placement During Bladder Surgery Can Reduce the Chances of Developing a Hernia
Status: ACTIVE_NOT_RECRUITING
Conditions: Radical Cystectomy
Interventions: PROCEDURE: Surgery Radical Cystectomy|PROCEDURE: Ultrapro mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil
Status: COMPLETED
Conditions: Perioperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Liraglutide on Body Weight Loss in Obese and Overweight Patients
Status: COMPLETED
Conditions: Obese|Overweight
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Detection of Clinically Significant Prostate Cancer With 18F-DCFPyL PET/MR
Status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasm, Prostate
Interventions: PROCEDURE: PET/MR-ultrasound guided Fusion biopsy|PROCEDURE: Systemic TRUS guided biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Axitinib (AG-013736) in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma
Status: COMPLETED
Conditions: Adenoid Cystic Carcinoma
Interventions: DRUG: AG-013736 (AXITINIB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Wedge Resection for Ground-glass Opacity-featured Lung Cancer (ECTOP-1020)
Status: NOT_YET_RECRUITING
Conditions: Lung Cancer|Wedge Resection|Ground-glass Opacity
Interventions: PROCEDURE: Wedge resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of the Persistence of Inflammation at Doppler Ultrasound Level on the Structural Evolution of Erosion in Rheumatoid Arthritis Treated With Biotherapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DEVICE: HR-pQCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Napabucasin (BBI-608) Plus Weekly Paclitaxel Versus Weekly Paclitaxel Alone in Patients With Advanced, Previously Treated, Non-Squamous Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Napabucasin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Effectiveness of Hyperimmune Anti-HIV Intravenous Immunoglobulin (HVIG) Plus Zidovudine in HIV-Infected Infants
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Anti-HIV Immune Serum Globulin (Human)|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Coagulation and Vitamin K in Head and Neck Microvascular Free Flap Surgery
Status: COMPLETED
Conditions: Head and Neck Cancer|Intraoperative Complications|Coagulation Disorder, Blood|Vitamin K Deficiency|Thrombosis|Anticoagulants and Bleeding Disorders|Head and Neck Procedural Complication
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AMelioration of Angiotensin Converting Enzyme Inhibitor Induced Angioedema Study
Status: COMPLETED
Conditions: Angioedema
Interventions: DRUG: Icatibant (subcutaneous) and plazebo (intravenous)|DRUG: Cortisone + Clemastin (intravenous) and plazebo (subcutaneous)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Night Pain in Patients With Rotator Cuff Syndrome
Status: COMPLETED
Conditions: Shoulder Pain|Shoulder Impingement Syndrome|Shoulder Tendinitis|Rotator Cuff Tear
Interventions: OTHER: Night Pain in Patients with Rotator Cuff Syndrome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Beef and Plant Burger Metabolomics Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammatory Response
Interventions: DIETARY_SUPPLEMENT: Grain-Fed Beef Hamburger|DIETARY_SUPPLEMENT: Grass-Fed Beef Hamburger|DIETARY_SUPPLEMENT: Impossible BurgerTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Reinforce Immunity (STRI) Phase 2 Clinical Trial
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: STRI Formula|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cisplatin, Etoposide, and Cyclophosphamide in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis
Status: COMPLETED
Conditions: Decompensated Cirrhosis|Bleeding Varices
Interventions: PROCEDURE: TIPS treatment|DRUG: Medical treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia
Status: COMPLETED
Conditions: Localized Provoked Vulvodynia
Interventions: DRUG: Botulin toxin|DRUG: physiological water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Android Artificial Pancreas System in Adult Patients With Type 1 Diabetes Mellitus in China
Status: RECRUITING
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 1|Glucose Metabolism Disorders|Metabolic Disease|Endocrine System Diseases|Autoimmune Diseases|Immune System Diseases
Interventions: DEVICE: AndroidAPS-rt-CGM;|DEVICE: sensor augmented pump(SAP);
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASsessment of Adherence TO Medication in AtRIAl Fibrillation - an eMonitoring Drug Dispensing Device Study
Status: UNKNOWN
Conditions: Adherence, Patient|Atrial Fibrillation
Interventions: BEHAVIORAL: Adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Senaparib in mCRPC Patients With Homologous Recombination Repair Gene Alterations After Docetaxel Treatment
Status: UNKNOWN
Conditions: mCRPC
Interventions: DRUG: Placebo|DRUG: Senaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer|Rectal Adenocarcinoma
Interventions: PROCEDURE: Nonoperative surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nationwide Long-term Outcome Surveillance of Physiomesh® vs. Other Meshes in Laparoscopic Incisional Hernia Repair
Status: COMPLETED
Conditions: Hernia, Abdominal|Recurrence|Postoperative Complications
Interventions: DEVICE: Physiomesh
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Determine Any Effect Of Tafamidis On Electrocardiographic Intervals, Specifically The Rate Corrected QT Interval (QTc)
Status: COMPLETED
Conditions: TTR Cardiomyopathy
Interventions: DRUG: Period 1|DRUG: Period 2|DRUG: Period 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Pharmacokinetic Comparison of Two Recombinant Exendin-4 Formulations in Chinese Healthy Male Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: rE-4 Injection|DRUG: rE-4 Freeze-dried Powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Runihol in Nonalcoholic Fatty Liver Disease and Metabolic Syndrome
Status: TERMINATED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Runihol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An RCT of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt
Status: COMPLETED
Conditions: Induction of Labor Affected Fetus / Newborn
Interventions: DEVICE: Dilapan-S|DRUG: Dinoprostone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "I am a Physically Active Person!": A Randomized Controlled Trial Aimed to Increase Levels of Physical Activity Self-Definition and Physical Activity Among a Sample of Inactive Adults
Status: COMPLETED
Conditions: Physical Activity Self-Definition|Physical Activity
Interventions: OTHER: Physical Activity Self-Definition|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Procured From Deceased Donors With High Kidney Donor Profile Index (KDPI)
Status: WITHDRAWN
Conditions: Ischemia Reperfusion Injury
Interventions: DRUG: Allogeneic adipose derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of GSK Biologicals' HPV-16/18 L1 VLP AS04 Vaccine (GSK-580299) in Healthy Female Children 4-6 Years Old
Status: COMPLETED
Conditions: Infections, Papillomavirus
Interventions: BIOLOGICAL: Cervarix|BIOLOGICAL: Priorix|BIOLOGICAL: Infanrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)
Status: RECRUITING
Conditions: Idiopathic CD4 Lymphopenia
Interventions: BIOLOGICAL: Belimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Subjective Effects of PTI-801 in Non-Physically Dependent Subjects With a History of Drug Abuse
Status: COMPLETED
Conditions: Opioid-Related Disorders
Interventions: DRUG: oxycodone and naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique
Status: TERMINATED
Conditions: Trigeminal Neuralgia|Headache Disorders
Interventions: DRUG: Glycerol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia
Status: UNKNOWN
Conditions: Astigmatism|Cataract
Interventions: PROCEDURE: phacoemulsification|DEVICE: Pentacam (Oculus,Germany)examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Peg-interferon Plus Ribavirin (IFN/RBV) for Prevention of Hepatocellular Carcinoma (HCC) Recurrence in Patients Who Had Surgery to Remove Primary HCC
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: interferon-alfa-2b and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of IV Casopitant for the Prevention of Nausea and Vomiting Caused By Cisplatin-Based Highly Emetogenic Chemotherapy
Status: WITHDRAWN
Conditions: Cancer|Chemotherapy-Induced Nausea and Vomiting|Nausea and Vomiting|Solid Tumor Cancer
Interventions: DRUG: Dexamethasone|DRUG: Dexamethasone|DRUG: IV casopitant (placebo)|DRUG: IV casopitant (active)|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 in Healthy Elderly Subjects
Status: COMPLETED
Conditions: Healthy Elderly Subjects
Interventions: DRUG: HSK3486|DRUG: HSK3486|DRUG: HSK3486|DRUG: HSK3486
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes
Status: COMPLETED
Conditions: Non Insulin Dependent Diabetes|Pregnancy
Interventions: DRUG: Metformin|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Radiotherapy and Concurrent Erlotinib (Tarceva®) for Brain Metastases From a Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer|Brain Metastases
Interventions: DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nebulized Adrenalin and Oral Betamethasone in Children With Bronchiolitis Attending Pediatric Emergencies.
Status: TERMINATED
Conditions: Children|Bronchiolitis
Interventions: DRUG: 0.9% saline solution|DRUG: oral betamethasone placebo|DRUG: adrenaline|DRUG: oral betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smoking Relapse-Prevention Intervention for Cancer Patients
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: Smoking Relapse Prevention for Cancer Patients (SRP-CaP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Liver Cancer Prevention Trial in Patients With Chronic Hep C Infection
Status: COMPLETED
Conditions: Adult Primary Liver Cancer|Hepatitis C Infection
Interventions: DRUG: S-adenosyl-L-methionine disulfate p-toluene-sulfonate|OTHER: placebo|OTHER: laboratory biomarker analysis|OTHER: immunoenzyme technique|OTHER: high performance liquid chromatography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Periodontal Status and hsCRP Levels in Females With PCOS on CPA/EE Combination Drug Regimen
Status: UNKNOWN
Conditions: Periodontitis|Polycystic Ovary Syndrome|Gingivitis
Interventions: DRUG: Cyproterone Acetate, Ethinyl Estradiol Drug Combination|DIAGNOSTIC_TEST: FEMALE PATIENTS WITH PCOS|DIAGNOSTIC_TEST: Control group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: QUILT-3.061: CD19 t-haNK in Subjects With Diffuse Large B-Cell Lymphoma
Status: WITHDRAWN
Conditions: Diffuse Large B Cell Lymphoma|Large-cell Lymphoma|Lymphoma, B-Cell|Lymphoma
Interventions: BIOLOGICAL: CD19 t-haNK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Palliative Chemotherapy With TS-1 and Oxaliplatin for Patients With Advanced Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Advanced Hepatocellular Carcinoma
Interventions: DRUG: SOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Role of HVPG and ICG-R15 in the Short- and Medium-term Results of the Surgery of HCC on Cirrhosis
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DIAGNOSTIC_TEST: Hepatic venous-portal gradient (HVPG) measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Follow-Up Of Pregnancies Established During Study NT-03 (Thrive-IVF Follow-Up)
Status: COMPLETED
Conditions: Repeated IVF Failure
Interventions: BIOLOGICAL: Post dosing with NT100|OTHER: Post dosing with Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Toothpastes With Thermal Water for Oral Health
Status: COMPLETED
Conditions: Gingivitis|Dentin Hypersensitivity
Interventions: DRUG: BUCCOTHERM® Sensitive Gums with Fluoride|DRUG: BUCCOTHERM® Sensitive Gums Fluoride-Free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virtual Reality and Peripheral Intravenous Catheter Insertion to Children (R3VP)
Status: UNKNOWN
Conditions: Virtual Reality|Catheterization, Peripheral Venous|Children, Only|Pain, Procedural
Interventions: OTHER: control arm|OTHER: anxiolytic and analgesic gas|DEVICE: Virtual reality mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Validating the Spanish "Attitudes Toward Genomics and Precision Medicine" (AGPM).
Status: ACTIVE_NOT_RECRUITING
Conditions: Adult ALL
Interventions: OTHER: Attitudes Toward Genomics and Precision Medicine (English)|OTHER: Attitudes Toward Genomics and Precision Medicine (Spanish)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of the Parents' Voice to Reduce the Heel Puncture Pain in High-Risk Neonates
Status: COMPLETED
Conditions: Pain
Interventions: BEHAVIORAL: Parents' Voice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study on the Safety of the Drug Runcaciguat and How Well it Works When Given at the Highest Dose as Tolerated by Individual Patient Whose Kidneys Are Not Working Properly and Suffering at the Same Time From High Blood Sugar and/or High Blood Pressure and a Disease of the Heart and the Blood Vessels.
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: runcaciguat|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pattern Of Endoscopic Findings In Patients Underwent Upper Endoscopy In Sohag University Hospital
Status: COMPLETED
Conditions: All Patients With Upper GIT Symptoms and Underwent Upper Endoscopy
Interventions: DIAGNOSTIC_TEST: upper endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Concomitant Administration of 13-valent Pneumococcal Conjugate Vaccine (13vPnC) With Influenza Vaccine in 23-valent Pneumococcal Polysaccharide (23vPS) Pre-vaccinated Adults.
Status: COMPLETED
Conditions: PREVENTION OF INVASIVE PNEUMOCOCCAL DISEASE
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: Seasonal Inactivated Influenza Vaccine|OTHER: Placebo|OTHER: Placebo|BIOLOGICAL: Seasonal Inactivated Influenza Vaccine|BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Evoglitin in Patients With Type 2 Diabetes and Non-alcoholic Fatty Liver Diseases
Status: COMPLETED
Conditions: Type2 Diabetes|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Evogliptin|DRUG: Pioglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Clinical Outcomes Following Implantation of a Sub-2mm Hydrophilic MICS Intraocular Lens
Status: COMPLETED
Conditions: Cataract
Interventions: PROCEDURE: IOL implantation|DEVICE: IOL Implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Combined Multidomain Intervention to Prevent Cognitive Decline Associated With Cardiovascular Risk Factors.
Status: RECRUITING
Conditions: Aging|Cardiovascular Risk Factor
Interventions: OTHER: Cognitive Training|OTHER: Aerobic and resistance exercises|OTHER: Stretching and Toning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Single/Multiple Dose Study Of PF-06293620 To Assess Safety, Tolerability And Pharmacokinetics In Subjects With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo|BIOLOGICAL: PF-06293620|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of TEAS on Postoperative Pain and Recovery in Patients Undergoing Pancreatectomy
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DEVICE: transcutaneous electrical acupoint stimulation|DEVICE: sham transcutaneous electrical acupoint stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vascularized Composite Bladder Allograft Transplantation
Status: RECRUITING
Conditions: Neurogenic Bladder|Bladder Dysfunction|Immunosuppression
Interventions: OTHER: Quality-of-Life Assessment|PROCEDURE: Robotic Vascularized Composite Bladder Allograft Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sculptra to Aid in Treatment of Arm Laxity
Status: UNKNOWN
Conditions: Skin Laxity
Interventions: DEVICE: injectable poly-L-lactic acid|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Injection Comfort of Two Formulations of ATX-101
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ATX-101-BA-free|DRUG: ATX-101-BA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effects of Alcohol and Caffeine
Status: COMPLETED
Conditions: Alcohol or Other Drugs Effects
Interventions: DRUG: Alcohol + Caffeine Beverage|DRUG: Alcohol + Caffeine-placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of a Diabetes Prevention Patient Activation Clinical Decision Support Tool
Status: ENROLLING_BY_INVITATION
Conditions: PreDiabetes|Lifestyle, Healthy|Activation, Patient
Interventions: BEHAVIORAL: Diabetes Prevention Patient Activation Clinical Decision Support Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cereals as a Source of Iron for Breastfed Infants
Status: COMPLETED
Conditions: Iron Deficiency
Interventions: DIETARY_SUPPLEMENT: electrolytic iron|DIETARY_SUPPLEMENT: ferrous fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Osteonecrosis of the Hip and Bisphosphonate Treatment
Status: UNKNOWN
Conditions: Osteonecrosis
Interventions: DRUG: Zoledronic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19
Status: ACTIVE_NOT_RECRUITING
Conditions: ARDS, Human|Covid-19
Interventions: BIOLOGICAL: Mesenchymal Stem Cells derived from Wharton Jelly of Umbilical cords
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Titanium Granules in the Treatment of Periodontal Intrabony Defects
Status: UNKNOWN
Conditions: Intrabony Periodontal Defect
Interventions: PROCEDURE: Titanium Granules|PROCEDURE: Hydroxyapatite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors
Status: TERMINATED
Conditions: Adenocarcinoma|Pancreatic Neoplasms
Interventions: DRUG: X-82|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness of Pharmaceutical Care on the Adherence of HIV-Positive Patients to Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV|HIV Infections
Interventions: BEHAVIORAL: pharmaceutical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: B-mode Ultrasound Imaging in Detecting Early Liver Cancer
Status: COMPLETED
Conditions: Cirrhosis|Early Hepatocellular Carcinoma|Fibrosis|Stage I Hepatocellular Carcinoma|Stage II Hepatocellular Carcinoma
Interventions: OTHER: Ultrasound Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia|Acute Lymphoblastic Leukemia|Acute Promyelocytic Leukemia
Interventions: OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Vaginal Hysterectomy, Laparoscopic Hysterectomy, Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: laparoscopy, laparoscopic hysterectomy|PROCEDURE: vaginal : vaginal hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Para-sartorial Compartment Block in Knee Surgery
Status: RECRUITING
Conditions: Knee Osteoarthritis|Knee Injuries|Knee Disease|Knee Arthritis
Interventions: DRUG: Postoperative analgesia management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cost-effectiveness Evaluation of One Stage Versus Two Stage Exchange for Chronically Infected Total Hip and Total Knee Prostheses
Status: UNKNOWN
Conditions: Chronically Infected Total Hip of Knee Prosthesis
Interventions: PROCEDURE: Exchange of total hip or knee arthroplasty on same time|PROCEDURE: Exchange of total hip or knee arthroplasty in two time
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Paclitaxel and Bavituximab in Treating Patients With HER2-Negative Metastatic Breast Cancer
Status: COMPLETED
Conditions: Human Epidermal Growth Factor 2 Negative Carcinoma of Breast|Male Breast Cancer|Recurrent Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: DRUG: paclitaxel|BIOLOGICAL: bavituximab|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Adapalene Gel 0.3% in Subjects With Facial Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene Gel 0.3%|DRUG: Differin 0.3% Topical Gel|DRUG: Adapalene Gel 0.3% Vehicle Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM
Status: COMPLETED
Conditions: Colo-rectal Cancer|Liver Metastases
Interventions: DRUG: Irinotecan|DRUG: Oxaliplatin|DRUG: Floxuridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multiple Dose Safety Study of NPT088 in Patients With Mild to Moderate Probable Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: NPT088|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Palonosetron on the QTc Interval During Perioperative Period
Status: COMPLETED
Conditions: Anesthesia, General|Palonosetron
Interventions: DRUG: Palonosetron|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: CMV-CTL for the Treatment of CMV Infection After HSCT
Status: COMPLETED
Conditions: Cytomegalovirus Infections|Hematological Disease
Interventions: BIOLOGICAL: donor derived cytomegalovirus specific T lymphocytes|DRUG: Foscarnet|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of BKM120 and Lapatinib in HER2+/PI3K-activated, Trastuzumab-resistant Advanced Breast Cancer
Status: SUSPENDED
Conditions: Breast Cancer
Interventions: DRUG: BKM120 + lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic vs Ultrasound Guided TAP Block in Colorectal Surgery. A Randomised Controlled Study.
Status: COMPLETED
Conditions: Laparoscopic Surgical Procedure|Nerve Block
Interventions: PROCEDURE: LAPTAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tissue Oximetry's Measurement in Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Oxygen Deficiency|Acute Kidney Injury|Ovarian Carcinoma
Interventions: DEVICE: Tissue Oximetry with ForeSight
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Humidity in Incubators for Tiny Infants
Status: NOT_YET_RECRUITING
Conditions: Extremely Premature Infant
Interventions: DEVICE: Incubator ambient relative humidity (RH) of 70%|DEVICE: Incubator ambient relative humidity (RH) of 90%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Open Label Trial to Compare BI 207127 to Telaprevir in HCV Patients
Status: WITHDRAWN
Conditions: Hepatitis C, Chronic
Interventions: DRUG: BI 201335|DRUG: ribavirin|DRUG: BI 207127|DRUG: Telaprevir|DRUG: ribavirin|DRUG: Pegylated Interferon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRICC-C (AIO-KRK-0111): BIBF 1120 Versus Placebo in Patients Receiving Oxaliplatin Plus Fluorouracil and Leucovorin (mFOLFOX6) for Advanced, Chemorefractory Metastatic Colorectal Cancer (mCRC)
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: mFOLFOX6 + BIBF 1120|DRUG: mFOLFOX6+placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes
Status: ACTIVE_NOT_RECRUITING
Conditions: Genital Herpes
Interventions: BIOLOGICAL: mRNA-1608|BIOLOGICAL: BEXSERO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Persistent Post-Concussion Symptoms With Convergence Insufficiency
Status: RECRUITING
Conditions: Persistent Post-concussive Symptoms|Convergence Insufficiency|Mild Traumatic Brain Injury|Concussion, Mild|Concussion; Eye
Interventions: BEHAVIORAL: Office-based Vergence and Accommodative Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Oral Alfacalcidol for Secondary Hyperparathyroidism in Chronic Hemodialysis Patients.
Status: COMPLETED
Conditions: Alfacalcidol, Secondary Hyperparathyroidism, Hemodialysis
Interventions: DRUG: Alfacalcidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation With CT Scan of Possible Changes in Airways After Treatment With Daxas® in Severe Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Roflumilast|DRUG: Placebo of Roflumilast|RADIATION: Functional Respiratory Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain.
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: Bupivacaine|DRUG: 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Day-time Response Variation of (Lis)Dexamphetamine
Status: COMPLETED
Conditions: Adhd
Interventions: DRUG: Dexamfetamine Sulfate 5 Mg Oral Tablet|DRUG: Lisdexamfetamine Dimesylate|BIOLOGICAL: blood samples
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Asian Study to Evaluate Efficacy and Safety of Oral Enzalutamide in Progressive Metastatic Prostate Cancer Participants
Status: COMPLETED
Conditions: Progressive Metastatic Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Palifermin before only|DRUG: Placebo|DRUG: Palifermin before and after
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Decitabine With GCLAM for Adults With Newly Diagnosed, Relapsed, or Refractory AML or High-Risk MDS
Status: COMPLETED
Conditions: Mixed Phenotype Acute Leukemia|Previously Treated Myelodysplastic Syndrome|Recurrent Adult Acute Myeloid Leukemia|Recurrent High Risk Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory High Risk Myelodysplastic Syndrome|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: Cladribine|DRUG: Cytarabine|DRUG: Decitabine|BIOLOGICAL: Filgrastim|OTHER: Laboratory Biomarker Analysis|DRUG: Mitoxantrone Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Black Seed Oil on Hemodialysis Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: End Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: Black Seed Oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT