pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nicotinamide as an Early Alzheimer's Disease Treatment
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: Nicotinamide|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mail Outreach To Increase Vaccination Acceptance Through Engagement
Status: COMPLETED
Conditions: Influenza, Human|Influenza|Human Flu
Interventions: BEHAVIORAL: Core letter signed by Surgeon General|BEHAVIORAL: Core letter signed by the Director of the National Vaccine Program|BEHAVIORAL: Core letter signed by Surgeon General + implementation prompt|BEHAVIORAL: Core letter signed by SG + enhanced implementation prompt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women (DiNOVasc-COVID-19)
Status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Diseases|Endothelial Dysfunction
Interventions: BIOLOGICAL: COVID-19 vaccine|BIOLOGICAL: Concentrate beetroot Juice|BIOLOGICAL: Nitrate-deplete beetroot juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity, Safety and Tolerability, of Chiron Meningococcal C Conjugate Vaccine Administered to Healthy Premature and Non Premature Children of 3 Months of Age
Status: COMPLETED
Conditions: Prevention of Meningococcal Infection
Interventions: BIOLOGICAL: Meningococcal C Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Retained Urine Volume and Bacteriuria in Traditional Versus Vented Urine Drainage Systems
Status: WITHDRAWN
Conditions: Bacteriuria
Interventions: DEVICE: Vented urinary drainage system|DEVICE: Non-vented urinary drainage system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety and Immunogenicity of Monovalent mRNA NA Vaccine in Adult Participants 18 Years of Age and Older
Status: COMPLETED
Conditions: Influenza Immunization|Healthy Volunteers
Interventions: BIOLOGICAL: mRNA NA vaccine|BIOLOGICAL: High Dose Quadrivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Golimumab in Participants With Ulcerative Colitis
Status: TERMINATED
Conditions: Colitis, Ulcerative
Interventions: OTHER: Placebo|DRUG: Golimumab 1 mg per kg|DRUG: Golimumab 2 mg per kg|DRUG: Golimumab 4 mg per kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: G-CSF|DRUG: Cytarabine|DRUG: Fludarabine|BIOLOGICAL: Donor Natural Killer (NK) cells|BIOLOGICAL: ALT-801
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Vitamin D Supplementation on Strength, Bone Density, and Injury Risk in Collegiate Athletes
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DRUG: Vitamin D 10000 UNT|DRUG: Vitamin D 5000 UNT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Nilotinib Versus Imatinib in Ph+ CML in Early CP Who Have a Suboptimal Molecular Response to Imatinib
Status: UNKNOWN
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Nilotinib, Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Examining the Effects of Reduced Environmental Stimulation on Anxiety
Status: COMPLETED
Conditions: Generalized Anxiety Disorder|Agoraphobia|Panic Disorder|PostTraumatic Stress Disorder|Social Anxiety Disorder|Major Depressive Disorder
Interventions: BEHAVIORAL: Floating|BEHAVIORAL: Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737)
Status: COMPLETED
Conditions: Atherosclerosis|Ischemia|Myocardial Infarction|Cerebrovascular Accident|Peripheral Arterial Disease
Interventions: DRUG: Vorapaxar|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Severe Surgical Site Infections (SSIs) Following Contaminated Or Dirty-infected Abdominal Surgery
Status: COMPLETED
Conditions: Surgical Wound Infection|Postoperative Wound Infection
Interventions: PROCEDURE: Elective or emergency abdominal surgery|PROCEDURE: Elective or emergency abdominal surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Brimonidine Tartrate Posterior Segment Drug Delivery System in Improving Visual Function
Status: COMPLETED
Conditions: Rhegmatogenous Macula-off Retinal Detachment
Interventions: DRUG: 400 ug Brimonidine Implant|DRUG: 200 ug Brimonidine Implant|OTHER: Sham (no implant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Description of Tolerability of LCZ696 (Sacubitril / Valsartan) in Heart Failure With Reduced Ejection Fraction (HFrEF) Treated in Real Life Setting
Status: COMPLETED
Conditions: Hearth Failure With Reduced Ejection Fraction (HFrEF)
Interventions: DRUG: LCZ696 (sacubitril/valsartan)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cisplatin Combined With Oral TS-1 in Patients With Advanced Solid Tumors With Different Degrees of Liver Dysfunction
Status: RECRUITING
Conditions: Cancer|Liver Dysfunction
Interventions: DRUG: TS-1 combined with cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pre-therapeutic Analysis of the Individual Radiosensitivity of Cancer Patients in Luxembourg (APRI-Lux): Prospective National Interventional Study With Minimal Risk
Status: UNKNOWN
Conditions: Radiosensitivity|Cancer|Radiation Toxicity
Interventions: BIOLOGICAL: Blood sample collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Role of Xanthophylls in Visual Function
Status: NOT_YET_RECRUITING
Conditions: Nutrition Deficiency (Xanth Deficiency) Due to A Particular Kind of Food
Interventions: DIETARY_SUPPLEMENT: luteine and zeaxanthine|DIETARY_SUPPLEMENT: luteine|DIETARY_SUPPLEMENT: zeaxanthine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Combined Fostamatinib and Paclitaxel in Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Fostamatinib and Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-Operative Testing for Cataract Surgery Among Adults in LA County
Status: COMPLETED
Conditions: Cataract
Interventions: BEHAVIORAL: No Pre-Op Testing for Cataract Surgeries
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of GSK573719 in Healthy Japanese Male Subjects
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK573719 250 μg|DRUG: GSK573719 500 μg|DRUG: GSK573719 1000 μg|DRUG: GSK573719 matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: FTIH of ECC4703 in Healthy Volunteers
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis (NASH)
Interventions: DRUG: ECC4703|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Glycemic Index, Glycemic Load and Insulinemic Index of Spanish Breads
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: OTHER: Ordinary white bread|OTHER: Precooked-Frozen White Bread|OTHER: Candeal-flour White Bread|OTHER: Alfacar White Bread|OTHER: Wholemeal Bread|OTHER: Glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Ticagrelor on No-reflow in Patients With Acute ST-segment Elevation Myocardial Infarction
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Coaching Program to Promote Physical Activity and Reduce Sedentary Behavior After a COPD Hospitalization
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Physical Activity|Sedentary Lifestyle
Interventions: BEHAVIORAL: Physical activity and sedentary behavior coaching program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP015K
Status: COMPLETED
Conditions: Healthy Subjects|Pharmacokinetics of ASP015K|Pharmacodynamics
Interventions: DRUG: ASP015K|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study of Mirdametinib on Its Own or in Combination With Fulvestrant in People With Solid Tumor Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Cancer Stage IV|HER2-negative Breast Cancer|Solid Carcinoma|MEK1 Gene Mutation|MEK2 Gene Mutation|Metastatic Breast Cancer
Interventions: DRUG: Mirdametinib|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Probiotics for Clostridium Difficile Infection in Older Adults
Status: COMPLETED
Conditions: Clostridium Difficile
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mental Intervention and Nicotinamide Riboside Supplementation in Long Covid
Status: RECRUITING
Conditions: Long COVID
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside (NR)|BEHAVIORAL: Mind-body reprocessing therapy (MBRT)|BEHAVIORAL: Care as usual|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Secukinumab on Radiographic Progression in Ankylosing Spondylitis as Compared to GP2017 (Adalimumab Biosimilar)
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: GP2017 (adalimumab biosimilar)|BIOLOGICAL: AIN457 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Serratus Plane Versus Paravertebral Nerve Blocks for Breast Surgery
Status: COMPLETED
Conditions: Breast Surgery
Interventions: DRUG: Serratus Plane block (single injection)|DRUG: Paravertebral block (single injection)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab /Apatinib for Recurrent Platinum-resistant Ovarian Cancer
Status: UNKNOWN
Conditions: Recurrent Platinum-resistant Ovarian Cancer
Interventions: DRUG: Camrelizumab (SHR-1210)|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Sampling and Processing of Samples for Molecular Microbial Research on Ocular Surface Samples
Status: COMPLETED
Conditions: Microbiota|Ocular Surface
Interventions: DIAGNOSTIC_TEST: Conjunctival swab|DRUG: Oxybuprocaine Hydrochloride 0.4% Eye Drops|DRUG: artificial tears
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: ExAblate Transcranial MRgFUS of the Subthalamic Nucleus for Treatment of Parkinson's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson's Disease
Interventions: DEVICE: ExAblate Transcranial System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19
Status: UNKNOWN
Conditions: Pneumonia, Pneumocystis|Coronavirus
Interventions: DRUG: Darunavir and Cobicistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualization Flow in Patients Treated With High Flow Nasal Therapy (iFLOW)
Status: UNKNOWN
Conditions: High-Flow Nasal Cannula|Oxygen Therapy|Acute Respiratory Failure|Respiratory Failure|Lung Injury
Interventions: DEVICE: High Flow Nasal Cannula at 30L/min|DEVICE: High Flow Nasal Cannula at 45L/min|DEVICE: High Flow Nasal Cannula at 60L/min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison the Effectiveness of Postoperative Incentive Spirometry and Noninvasive Mechanical Ventilation in Patients Following Craniotomy
Status: UNKNOWN
Conditions: Neoplasms, Intracranial
Interventions: DEVICE: Plasti-med TRIFLO|DEVICE: BIPAP VISION|DEVICE: Plasti-med oxygen therapy mask
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Status: TERMINATED
Conditions: Colorectal Cancer
Interventions: DRUG: mesalamine 2400 MG (5-ASA)|DRUG: mesalamine 1200 MG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prediction of Bleeding Risk After Anticoagulant Therapy for Atrial Fibrillation Based on Proteomics and Metabolomics
Status: UNKNOWN
Conditions: Atrial Fibrillation|Bleeding|Anticoagulant Therapy
Interventions: DIAGNOSTIC_TEST: Proteomics|DIAGNOSTIC_TEST: Metabolomics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Surgical Management of Posterior Malleolar Fractures Using the Direct or Indirect Reduction Techniques
Status: COMPLETED
Conditions: Posterior Malleolus Fractures
Interventions: PROCEDURE: direct fracture reduction and fixation|PROCEDURE: indirect fracture reduction and fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to Assess Acceptability and Safety of Two Placebo Intravaginal Rings
Status: RECRUITING
Conditions: Safety|Acceptability
Interventions: DEVICE: Placebo Intravaginal Ring A|DEVICE: Placebo Intravaginal Ring B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain
Status: RECRUITING
Conditions: Interstitial Cystitis
Interventions: DRUG: Multimodal Bundle Drugs|PROCEDURE: Operative Cystoscopy|BEHAVIORAL: Behavioral health consultation/therapy|OTHER: Pelvic floor physical therapy|OTHER: Usual Urogynecologic care|DRUG: Bladder Instillation|DRUG: Vaginal estrogen|DRUG: Methenamine|DRUG: Amitriptyline/Gabapentin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Camrelizumab, Apatinib Mesylate and Nab-paclitaxel Combined With Oxplatin and S-1 in the Neoadjuvant Treatment of Locally Advanced Gastric Cancer With Different Genotypes
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Gastric Cancer
Interventions: DRUG: Camrelizumab|DRUG: Oxaliplatin|DRUG: S1|DRUG: Apatinib Mesylate|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radicle Calm 24: A Study of Health and Wellness Products on Feelings of Anxiety and Related Health Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety|Stress
Interventions: DIETARY_SUPPLEMENT: Placebo Control Form 1|DIETARY_SUPPLEMENT: Calm Active Study Product 1.1 Usage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
Status: RECRUITING
Conditions: Anal Melanoma|Bladder Melanoma|Cervical Melanoma|Esophageal Melanoma|Gallbladder Melanoma|Mucosal Melanoma|Mucosal Melanoma of the Head and Neck|Mucosal Melanoma of the Urinary System|Nasopharyngeal Melanoma|Oral Cavity Mucosal Melanoma|Penile Mucosal Melanoma|Rectal Melanoma|Recurrent Mucosal Melanoma|Sinonasal Mucosal Melanoma|Stage II Vulvar Cancer AJCC v8|Stage III Vulvar Cancer AJCC v8|Stage IV Vulvar Cancer AJCC v8|Urethral Melanoma|Vaginal Melanoma|Vulvar Melanoma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Nivolumab|DRUG: Placebo Administration|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 3D-Printed Aerosolized Medication Delivery Assist Device in Patients With Chronic Respiratory Diseases
Status: NOT_YET_RECRUITING
Conditions: Chronic Pulmonary Disease
Interventions: OTHER: Use soft mist inhaler|DEVICE: Use soft mist inhaler with a 3D assistive device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Interest of Oxygenated Hypothermic Perfusion (PHO) in Preservation of Hepatic Grafts From Expanded Criteria Donors
Status: COMPLETED
Conditions: Hepatocellular Injury
Interventions: DEVICE: Hypothermic oxygenated perfusion (HOPE)|OTHER: Conventional cold storage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography Using 3'-Deoxy-3'-(18F) Fluorothymidine in Treating Women With Locally Advanced Cancer in One Breast Who Are Receiving Chemotherapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: 3'-deoxy-3'-[18F]fluorothymidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Rebox Current in Pain Management
Status: RECRUITING
Conditions: Electric Stimulation Therapy
Interventions: DEVICE: Rebox-Physio 4 (real stimulation)|DEVICE: Rebox-Physio 4 (sham stimulation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Combining Multiple Class I Peptides and Montanide ISA 51VG With Escalating Doses of Anti-PD-1 Antibody Nivolumab or Ipilimumab With Nivolumab For Patients With Resected Stages IIIC/ IV Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: NY-ESO-1 157-165 (165V)|DRUG: Nivolumab|BIOLOGICAL: gp100:280-288 (288V)|DRUG: Montanide ISA 51 vegetable grade (VG)|DRUG: Ipilimumab|PROCEDURE: Apheresis Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenofovir to Prevent HBV Reactivation
Status: UNKNOWN
Conditions: Hepatitis B|Lymphoma|Non-Hodgkin
Interventions: DRUG: Tenofovir disoproxil|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Non-ST Elevation Myocardial Infarction
Status: COMPLETED
Conditions: Non-ST Elevation Myocardial Infarction
Interventions: DRUG: Tocilizumab 280 mg|DRUG: NaCl 0.9% 100 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A(H7N9) VLP Antigen Dose-Ranging Study With Matrix-M1™ Adjuvant
Status: COMPLETED
Conditions: Influenza (Pandemic)
Interventions: BIOLOGICAL: Monovalent Avian Influenza VLP (H7N9)|BIOLOGICAL: Matrix-M1™ adjuvant|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tacks Versus Glue for Mesh Fixation in Laparoscopic Ventral Hernia Repair Treating Defects Between 2 and 5 cm Width
Status: TERMINATED
Conditions: Ventral Hernia
Interventions: DEVICE: Liquiband Fix8|DEVICE: Absorbable tack
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Home-based REsistance vs a Home-based FLEXbility Exercise Programmes on Muscular Endurance and Flexibility in Adults
Status: UNKNOWN
Conditions: Exercise
Interventions: BEHAVIORAL: Flexibility exercise programme|BEHAVIORAL: Resistance exercise programme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule
Status: RECRUITING
Conditions: Hydatidiform Mole|Gestational Trophoblastic Neoplasia
Interventions: OTHER: Follow up|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Intravenous Infusion With Nemonoxacin Malate Sodium Chloride
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Nemonoxacin 500 mg|DRUG: Nemonoxacin 650 mg|DRUG: Moxifloxacin 400 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Decreasing Upper and Shoulder Pain After Laparoscopic Surgery
Status: UNKNOWN
Conditions: Shoulder Pain|Nausea
Interventions: PROCEDURE: Pulmonary recruitment maneuver|PROCEDURE: Intraperitoneal normal saline infusion|PROCEDURE: combined group|PROCEDURE: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KD019 Versus Erlotinib in Subjects With Stage IIIB/IV Non Small Cell Lung Cancer With Progression After First- or Second-Line Chemotherapy
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: KD019|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy
Status: COMPLETED
Conditions: Sedation
Interventions: DRUG: Remimazolam Tosilate|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Hydroxychloroquine|DRUG: Lipiodol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suture Fixation System Versus Tendonous Reconstruction in Carpometacarpal (CMC) Arthroplasty
Status: COMPLETED
Conditions: Thumb Carpometacarpal Arthritis
Interventions: PROCEDURE: Ligament reconstruction with suture fixation system|PROCEDURE: Ligament Reconstruction with Tendon Interposition (LRTI)|PROCEDURE: Ligament reconstruction with suture fixation system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Embryo Transfer vs. Double Embryo Transfer in an Oocyte Donation Programme
Status: TERMINATED
Conditions: Infertility|Oocyte Recipient|Single Embryo Transfer/Double Embryo Transfer|Cumulative Pregnancy Rate|Multiple Pregnancy
Interventions: OTHER: Select the Number of embryos to transfer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Romidepsin in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: Bortezomib|DRUG: Romidepsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creatine Supplementation in Patients With Intermittent Claudication.
Status: UNKNOWN
Conditions: Intermittent Claudication
Interventions: DIETARY_SUPPLEMENT: Creatine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Saxagliptin, Onglyza|DRUG: Dapagliflozin, Farxiga|DRUG: Glargine insulin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Status: COMPLETED
Conditions: Squamous Neck Carcinoma of the Head and Neck Cancer (SCCHN)
Interventions: DRUG: Tirapazamine|DRUG: Cisplatin|DRUG: 5-fluorouracil|RADIATION: Radiotherapy (RT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Acceptance and Commitment Approach-Based Psychoeducation on Nursing Students' Psychological Distress
Status: ACTIVE_NOT_RECRUITING
Conditions: Psychological Distress
Interventions: BEHAVIORAL: Acceptance and commitment approach-based psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Anlotinib Hydrochloride Combined With Epirubicin and Ifosfamide for Soft Tissue Sarcoma Patients
Status: UNKNOWN
Conditions: Sarcoma, Soft Tissue
Interventions: DRUG: anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sous Vide Rewarming for Frostbitten Extremities
Status: COMPLETED
Conditions: Frostbite|Frostbite of Hand|Frostbite of Foot
Interventions: DEVICE: Sous Vide Device (SVD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BE Study of the Combinations of Gemigliptin 50mg and Metformin HCl Extended Release 1000mg in Comparison to Each Component Administered Alone
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: gemigliptin and metformin HCl extended release|DRUG: gemigliptin/metformin HCl extended release
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment of the Human Intestinal and Salivary Microbiota Biobank - Kidney Diseases
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)|Advanced-Chronic Kidney Disease (CKD)|Diabetic Kidney Disease (DKD)|IgA Nephropathy (IgAN)
Interventions: OTHER: Biological sample collection|OTHER: Questionnaire|OTHER: Medical examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas
Status: COMPLETED
Conditions: Type 1 Diabetes|Type 1 Diabetes Mellitus|Hyperglycemia, Postprandial
Interventions: DRUG: Fiasp|DRUG: Pramlintide Acetate|DRUG: Placebo|DEVICE: Artificial Pancreas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NIR Arthroscopic Fluorescence Angiography of Menisci
Status: UNKNOWN
Conditions: Meniscus Rupture
Interventions: PROCEDURE: NIR fluorescence imaging of the vascular perfusion of the meniscus using ICG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Abdominal Massage on Gastric Problems in Pediatric Intensive Care: A Randomized Controlled Study
Status: UNKNOWN
Conditions: Intensive Care Units, Pediatric|Massage|Nutrition Disorders|Nurse's Role
Interventions: OTHER: Abdominal massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Research of Biomarkers of Activity and Efficacy of BIBW2992 in Untreated Non-metastatic HNSCC Patients
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of Head and Neck
Interventions: DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Technological Based Rehabilitation on Individuals With Rheumatic Disease
Status: RECRUITING
Conditions: Rheumatic Diseases|Hand Rheumatism|Virtual Reality Therapy
Interventions: OTHER: Virtual reality therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: biphasic insulin aspart 30|DRUG: biphasic insulin aspart 30|DRUG: sitagliptin|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance Of Lithium Disilicate Crowns Restoring Endodontically Treated Teeth With Two Occlusal Preparation Schemes
Status: COMPLETED
Conditions: Fracture of Lithium Disilicate (e.Max) Crowns
Interventions: PROCEDURE: Abutments with flat occlusal scheme preparation restored by lithium disilicate crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Placement Duration of Pancreatic Duct Stent
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholangitis|Post-ERCP Acute Pancreatitis|Stent Dislodgement
Interventions: PROCEDURE: Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Insulin Degludec vs Insulin Glargine for Glycemic Control in Critical Illness Hyperglycemia
Status: COMPLETED
Conditions: Glycemic Control|Insulin|Critical Illness
Interventions: DRUG: Insulin Glargine|DRUG: Insulin Degludec|DRUG: Insulin regular
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dolutegravir on Metformin Pharmacokinetics in Healthy Adult Subjects
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: Metformin 500 mg q12h|DRUG: Dolutegravir 50 mg q24h|DRUG: Dolutegravir 50 mg q12h
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.
Status: COMPLETED
Conditions: Sarcopenia
Interventions: OTHER: Resistance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Plasma in Hiatal Hernia Repair
Status: ENROLLING_BY_INVITATION
Conditions: Hiatal Hernia Large|Reflux, Gastroesophageal
Interventions: PROCEDURE: Hiatal Hernia Repair with Platelet Rich Plasma|PROCEDURE: Hiatal Hernia Repair without Platelet Rich Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Atomoxetine on Brain Activation During Attention & Reading Tasks in Participants With ADHD & Comorbid Dyslexia
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Dyslexia
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine, Idarubicin, Cytarabine, Vincristine Sulfate, and Dexamethasone in Treating Patients With Newly Diagnosed or Relapsed Mixed Phenotype Acute Leukemia
Status: COMPLETED
Conditions: Acute Bilineal Leukemia|Acute Biphenotypic Leukemia|Acute Leukemia of Ambiguous Lineage|Acute Undifferentiated Leukemia|Mixed Phenotype Acute Leukemia|Mixed Phenotype Acute Leukemia, B/Myeloid, Not Otherwise Specified|Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified|Recurrent Mixed Phenotype Acute Leukemia
Interventions: DRUG: Clofarabine|DRUG: Cytarabine|DRUG: Dexamethasone|DRUG: Idarubicin|BIOLOGICAL: Rituximab|DRUG: Sorafenib|DRUG: Sorafenib Tosylate|DRUG: Vincristine|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quadratus Lumborum Block Versus Dual Transversus Abdominis Plane and Ilioinguinal/Iliohypogastric Nerve Blocks for Postoperative Analgesia Following Total Abdominal Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy
Interventions: PROCEDURE: Quadratus Lumborum Block|PROCEDURE: Dual Transversus Abdominis Plane and Ilioinguinal/Iliohypogastric Nerve blocks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Three Surgical Techniques to Achieve Patella Symmetry During Resection
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Injuries, Knee
Interventions: PROCEDURE: Cutting Guide Technique|PROCEDURE: Haptic Feedback Technique|PROCEDURE: Four Quadrant Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Tap Block in Patients After Hysterectomy
Status: UNKNOWN
Conditions: Abdominal Hysterectomy (& Wertheim)
Interventions: PROCEDURE: TAP BLOCK 0.2% ROPIVACAINE|PROCEDURE: TAP BLOCK 0.4% ROPIVACAINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers to Classify Young Patients With Acute Lymphoblastic Leukemia (ALL) and Remission Induction Therapy in Young Patients With B-Precursor ALL
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: SC-PEG E. coli L-asparaginase|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: methotrexate|DRUG: pegaspargase|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc
Status: RECRUITING
Conditions: Zinc Deficiency|Inflammation|Metabolic Diseases|Vascular Diseases
Interventions: OTHER: Beef protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Candidate Influenza Vaccine MVA-NP+M1 in Adults
Status: TERMINATED
Conditions: Influenza
Interventions: BIOLOGICAL: MVA-NP+M1|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: "The Efficacy of 'Radioguided Occult Lesion Localization' (ROLL) Versus 'Wire-guided Localization' (WGL) in Breast Conserving Surgery for Non-palpable Breast Cancer: a Randomized Clinical Trial"
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Radio guided occult lesion localisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Malignant Wounds, Wound Treatment, Psycho-Social Support and Relaxation Therapy
Status: COMPLETED
Conditions: Cancer|Malignant Wounds
Interventions: PROCEDURE: Wound treatment|PROCEDURE: wound treatment|OTHER: psycho-social support|OTHER: relaxation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Pupil Dilation Speed With the MAP Dispenser
Status: COMPLETED
Conditions: Mydriasis
Interventions: DRUG: tropicamide-phenylephrine fixed combination ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Multiple Ascending Dose Study of the mTOR Inhibitor (RAD001) in Combination With R1507 in Patients With Advanced Solid Tumors
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: RAD001|DRUG: RG1507
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Combination of Beclomethasone Dipropionate and Formoterol Fumarate Versus Single Components Assessed by Knemometry and Urinary Cortisol Measurements in Asthmatic Children
Status: COMPLETED
Conditions: Childhood Asthma
Interventions: DRUG: CHF 1535 50/6µg|DRUG: beclomethasone dipropionate 50µg + formoterol fumarate 6µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of a Fixed or a Flexible Supplementary Insulin Therapy in Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin detemir|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Fasting Mimicking Diet on Sperm Quality
Status: COMPLETED
Conditions: Sub Fertility, Male|Fertility Disorders|Sperm Count, Low
Interventions: BEHAVIORAL: Fasting Mimicking Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial Comparing Isolite® vs. Cotton Roll Isolation in the Placement of Dental Sealants
Status: COMPLETED
Conditions: Dental Caries on Pit and Fissure Surface
Interventions: DEVICE: Isolite System|OTHER: Cotton Roll Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dextrose Infusion by Burettes Versus Dextrose Boluses in Prevention of Neonatal Hypoglycemia
Status: TERMINATED
Conditions: Once a Preterm Developed Hypoglycemia, no More Blood Glucose Was Measured During the Study Period.
Interventions: DRUG: 10% dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan
Status: COMPLETED
Conditions: Bacterial Meningitis
Interventions: BIOLOGICAL: Meningococcal ACWY conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: RAAS and Arterial Stiffness in SCI
Status: UNKNOWN
Conditions: Arterial Stiffness|Renin Angiotensin Aldosterone System|Orthostatic Hypotension|Spinal Cord Injury|Hypotension
Interventions: OTHER: Spinal Cord Injury
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Ketamine Administered by Mesotherapy in Complex Regional Pain Syndrome Type 1 (CRPS1)
Status: COMPLETED
Conditions: Neuropathic Pain|Complex Regional Pain Syndrome Type 1
Interventions: DRUG: LIDOCAINE 20 mg|DRUG: LIDOCAINE 20 mg + KETAMINE 20 mg|DRUG: LIDOCAINE 20 mg + KETAMINE 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study to Evaluate Efficacy of Calaspargase Pegol-mknl and Decitabine Combined With Venetoclax in Pediatric, Adolescent, and Young Adult Patients With Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia (T-ALL) and T- Cell Lymphoblastic Lymphoma (T-LLy)
Status: NOT_YET_RECRUITING
Conditions: T-cell Acute Lymphoblastic Leukemia|T-Cell Lymphoblastic Lymphoma
Interventions: DRUG: Decitabine|DRUG: Venetoclax|DRUG: Calaspargase pegol-mknl
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide/Low-dose Dexamethasone in Combination With Continuous Oral Cyclophosphamide Compared to Lenalidomide/Low-dose Dexamethasone Combined With Single Cyclophosphamide Doses IV in Patients With Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Cyclophosphamide|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence And Effect Of Food And Water On Lamotrigine in Healthy Volunteers
Status: COMPLETED
Conditions: Mental Disorders
Interventions: DRUG: Lamotrigine IR tablets|DRUG: Lamotrigine ODT tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia
Status: COMPLETED
Conditions: Sickle Cell Anemia|Malaria
Interventions: DRUG: sulfadoxine pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Voluntary Activation During Isokinetic Contractions in Subjects With Neuromotor Disorders
Status: RECRUITING
Conditions: Multiple Sclerosis|Poststroke/CVA Hemiparesis|Parkinson Disease|Knee Impairment
Interventions: OTHER: Pathologic group
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Occlusal Stabilization Splints and Sleep Disordered Breathing
Status: WITHDRAWN
Conditions: Sleep Bruxism
Interventions: DEVICE: Maxillary OSS|DEVICE: Mandibular OSS|DEVICE: Modified farrar splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Cerebral and Cerebellar rTMS in Stroke Patient
Status: COMPLETED
Conditions: Stroke|Repetitive Transcranial Magnetic Stimulation|rTMS|Motor Recovery
Interventions: PROCEDURE: Repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT