pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Metformin Hydrochloride (HCl) in Combination With Colesevelam HCl, Compared to Metformin HCl Alone, in Patients With Type 2 Diabetes Mellitus and the Effects of Colesevelam HCl on Lipids and Glucose on Pre-diabetic Patients.
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus|Hypercholesterolemia|Pre-diabetes
Interventions: DRUG: Metformin HCl and Colesevelam Placebo|DRUG: Metformin HCl tablets and Colesevelam tablets|DRUG: Colesevelam placebo|DRUG: Colesevelam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Finding the Cause for Post-Transplant Diabetes Mellitus After Allogeneic Hematopoietic Cell Transplant
Status: RECRUITING
Conditions: Diabetes Mellitus|Cancer
Interventions: DRUG: Oral Glucose Tolerance Test (OGTT)|DRUG: 2 OGTTs with and without GLP-1 analogue|DRUG: Hyperglycemic clamp procedure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sonification Techniques for Gait Training
Status: RECRUITING
Conditions: Parkinson Disease|Stroke|Multiple Sclerosis
Interventions: DEVICE: Gait rehabilitation with "sonification"|OTHER: Standard gait rehabilitation (without sonification)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Older Adults with Cognitive Impairment Doing Sit to Stands, Walking in Transitional Care Programs: a Feasibility Study
Status: RECRUITING
Conditions: Cognitive Impairment|Dementia|Delirium|Functional Decline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Health Literacy Assessment and Intervention to Reduce Disparities: FLIGHT/VIDAS II
Status: COMPLETED
Conditions: Fatigue|Depression|Pain|Sleep Wake Disorders|Chronic Disease
Interventions: BEHAVIORAL: Tailored Intervention|BEHAVIORAL: Control Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAsting and REhabilitation Versus Supervised Neglect for Osteochondral Lesions of the Talus in the Pediatric Population
Status: NOT_YET_RECRUITING
Conditions: Cartilage Injury|Orthopedic Disorder|Skeletal Injury|Rehabilitation|Physiotherapy
Interventions: OTHER: Casting and supervised rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants
Status: COMPLETED
Conditions: Osteoarthritis of the Knee|Coagulopathy
Interventions: DRUG: Pennsaid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevention of Hypergranulation Tissue After Gastrostomy Tube Placement
Status: COMPLETED
Conditions: Soft Tissue Inflammation
Interventions: PROCEDURE: Standard Hydrocolloid Dressing|PROCEDURE: Silver Hydrocolloid Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Miconazole and Hydrocortisone Cream in the Treatment of Vulvar Candidiasis
Status: COMPLETED
Conditions: Vulva; Candidiasis
Interventions: DRUG: Miconazole plus Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Viscosupplementation Associated With Intra-articular Corticosteroid Injection Versus Intra-articular Injection of Corticosteroids Alone in Osteoarthritis of Hip
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: DEVICE: Experimental group|DEVICE: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Immediate vs. Delayed Cord Clamping in the Preterm Neonate
Status: COMPLETED
Conditions: PreTerm Birth|PreTerm Neonate
Interventions: PROCEDURE: Delayed Cord Clamping|PROCEDURE: Immediate Cord Clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Psoriatic Arthritis Who Have an Inadequate Response or Are Intolerant to Biologic DMARD Therapy
Status: TERMINATED
Conditions: Psoriatic Arthritis
Interventions: DRUG: Filgotinib|DRUG: Placebo to match filgotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anthocyanins as Dementia Prevention?
Status: UNKNOWN
Conditions: Dementia|Inflammation|Mild Cognitive Impairment|Coronary Artery Disease
Interventions: DIETARY_SUPPLEMENT: Anthocyanins|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Budesonide Application Via Mucosal Atomization Device as a Treatment for Chronic Rhinosinusitis When Utilized as a Topical Nasal Steroid Spray
Status: COMPLETED
Conditions: Chronic Rhinosinusitis
Interventions: DEVICE: Mucosal Atomization Device (MAD)|DEVICE: Budesonide via Nasal Syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus and Brentuximab Vedotin in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
Status: TERMINATED
Conditions: Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|DRUG: Everolimus|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study Comparing the Efficacy and Safety of IDP-126 Gel in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: IDP-126 Gel|DRUG: IDP-126 Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Treatment of Aortic Stenosis With a Next Generation, Rapid Deployment Surgical Aortic Valve
Status: COMPLETED
Conditions: Aortic Valve Stenosis|Aortic Valve Stenosis With Insufficiency|Regurgitation, Aortic Valve|Aortic Valve Incompetence
Interventions: DEVICE: EDWARDS INTUITY valve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371
Status: COMPLETED
Conditions: Tuberculosis|Tuberculosis, Pulmonary
Interventions: DRUG: TBA-7371|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A 12 Week Randomized Open Label Parallel Group Multicenter Study to Evaluate Bioequivalence of 20 mg Subcutaneous Ofatumumab Injected by Pre-filled Syringe or Autoinjector in Adult RMS Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: COMBINATION_PRODUCT: ofatumumab with PRF|COMBINATION_PRODUCT: ofatumumab with AI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Implants Restored With Advanced Lithium Disilicate Screw-retained Crowns
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Prosthesis Failure|Dental Prosthesis Complication
Interventions: DEVICE: CEREC System by Dentsply Sirona
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis of Oxaliplatin
Status: WITHDRAWN
Conditions: Colorectal Carcinoma|Neoplasms, Colorectal|Colorectal Cancer|Colorectal Tumors|Metastasis
Interventions: DIETARY_SUPPLEMENT: Glutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols
Status: COMPLETED
Conditions: Oxidative Stress|Inflammation
Interventions: OTHER: Yogurt enriched with polyphenols|OTHER: Yogurt not enriched with polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops
Status: UNKNOWN
Conditions: Congenital Hereditary Endothelial Dystrophy of Cornea
Interventions: DRUG: Nepafenac 0.1% Oph Susp|DRUG: Refresh Tears 0.5% Lubricant Eye Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Two-part Multiple Dose Study to Assess the Safety and Effects of AZD3293 in Healthy Elderly and Alzheimer's Patients
Status: COMPLETED
Conditions: Healthy Elderly Volunteers|Mild-to-moderate Alzheimer's Disease Patients
Interventions: DRUG: AZD3293|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries
Status: WITHDRAWN
Conditions: Bunion|Metatarsophalangeal Fusion|Midfoot Fusion|Hindfoot Fusion|Total Ankle Arthroplasty|Forefoot Surgery
Interventions: DRUG: EXPAREL 13.3Mg/mL Suspension for Injection|DRUG: Bupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dapagliflozin on HDL Particles Subtypes and Reverse Cholesterol Transport in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Balance Training on Vestibular Function and Proprioception Feedback in Stroke Patient
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: OTHER: Traditional physical therapy balance exercise|OTHER: proprioception based balance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Research Study Looking at How the Compound NNC0487-0111 Works With Birth Control Pills and Affects Emptying of the Stomach in Women Not Able to Become Pregnant
Status: RECRUITING
Conditions: Obesity
Interventions: DRUG: NNC0487-0111 A|DRUG: NNC0487-0111 C|DRUG: Levonorgestrel 150 μg + Ethinylestradiol 30 μg (Oral contraceptive OC)|DRUG: Acetaminophen - 500 mg/15 ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sintilimab and Chidamide in Combination With or Without IBI305 in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Microsatellite Stable Colorectal Cancer|Metastatic Microsatellite-stable Colorectal Cancer
Interventions: DRUG: Sintilimab|DRUG: Chidamide|DRUG: IBI305
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Doses Mesalazine Granules Versus Placebo for the Prevention of Recurrence of Diverticulitis
Status: TERMINATED
Conditions: Diverticulitis
Interventions: DRUG: Mesalazine|DRUG: Mesalazine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer|Cognitive Impairment
Interventions: DRUG: N-Acetyl-Cysteine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Efficacy and Safety of Fruquintinib (HMPL-013) in Participants With Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer|Metastatic Colon Cancer
Interventions: DRUG: Fruquintinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Marketing Study to Evaluate the Two Dose Regimens of Nicardipine Injection in Hypertensive Emergency Patients
Status: COMPLETED
Conditions: Hypertension Emergency|End-organ Damage
Interventions: DRUG: Perdipine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Health Virtual Reality Study
Status: RECRUITING
Conditions: Aging|Aging Problems|Memory Loss|Memory Impairment|Memory Disorders in Old Age|Memory Disorder, Spatial|Memory Disorders|Mild Cognitive Impairment|Cognitive Decline|Cognitive Change|Cognition Disorders in Old Age
Interventions: BEHAVIORAL: Physical Activity|BEHAVIORAL: Cognitive Activity (VR)|BEHAVIORAL: Physical and Cognitive Activity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Validation of a New Innovative Method for Specific Marker Detection in Celiac Disease
Status: RECRUITING
Conditions: Celiac Disease in Children
Interventions: DIAGNOSTIC_TEST: Diagnostic Test: Rapid Intestinal anti-TG2 Assay|DIAGNOSTIC_TEST: Diagnostic Test: Rapid Intestinal anti-TG2 Assay
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial Comparing Two Strategies of Vaccination Against Hepatitis B in HIV-infected Patients Non Responding to Primary Immunization (B-BOOST)
Status: COMPLETED
Conditions: Hepatitis B|HIV Infection
Interventions: BIOLOGICAL: GenHevac-B|BIOLOGICAL: GenHevac-B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Oral Bioavailability,and Food Effect Study and Single Ascending Dose PK Study in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Indoximod base formulation|DRUG: Indoximod HCL (salt) formulation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SurgiWrapTM to Reduce Soft Tissue Attachment & Incidence Early Post-Operative Bowel Obstruction in Colorectal Surgery
Status: COMPLETED
Conditions: Adhesions|Colectomy
Interventions: OTHER: Polylactic Acid Sheet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Pulsed Light Therapy for Meibomian Gland Dysfunction and Dry Eye Syndrome
Status: WITHDRAWN
Conditions: Meibomian Gland Dysfunction|Dry Eye Syndrome
Interventions: DEVICE: Sham Treatment|DEVICE: Pulsed Light Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Computerized Training of Attention and Working Memory in Post COVID-19 Patients With Cognitive Complaints
Status: ENROLLING_BY_INVITATION
Conditions: COVID-19|Cognitive Impairment|Cognition Disorder|Memory Disorders|Attention Deficit|Memory Impairment|Memory Loss|Attention Impaired
Interventions: DEVICE: RehaCom
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Efficacy and Safety of Albiglutide in Subjects With Type 2 Diabetes With Renal Impairment.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BIOLOGICAL: albiglutide|DRUG: sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: African American Study of Kidney Disease and Hypertension
Status: COMPLETED
Conditions: Hypertensive Nephrosclerosis|Chronic Renal Insufficiency
Interventions: OTHER: MAP goal less than or equal to 92 mm Hg|OTHER: MAP goal 102-107 mm Hg|DRUG: Ramipril|DRUG: Amlodipine|DRUG: Metoprolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Absorption From Iron Fortified Extruded Rice Co-fortified With Various Solubilizing Agents
Status: UNKNOWN
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: Reference meal 1|DIETARY_SUPPLEMENT: Reference 2|DIETARY_SUPPLEMENT: Test meal A|DIETARY_SUPPLEMENT: Test meal B|DIETARY_SUPPLEMENT: Test meal C|DIETARY_SUPPLEMENT: Test meal D|DIETARY_SUPPLEMENT: Test meal E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Atezolizumab Given in Combination With a Personalized Vaccine in Patients With Urothelial Cancer
Status: COMPLETED
Conditions: Urothelial/Bladder Cancer, Nos
Interventions: DRUG: Atezolizumab|BIOLOGICAL: PGV001|DRUG: Poly ICLC|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Significant Mitral Regurgitation in Acute Heart Failure Patients
Status: COMPLETED
Conditions: Acute Heart Failure|Mitral Regurgitation
Interventions: PROCEDURE: Transthoracic Echocardiogram (TTE) Assesment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SWEET: Postpartum Navigation After GDM
Status: COMPLETED
Conditions: Gestational Diabetes|Preventive Care / Anticipatory Guidance|Retention in Care|Postpartum Health|Lifestyle Modification
Interventions: BEHAVIORAL: Patient Navigation Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of VXCO-100, a SARS-CoV Candidate Vaccine in Healthy Adults in the United States
Status: ACTIVE_NOT_RECRUITING
Conditions: SARS-CoV|SARS-CoV-2
Interventions: BIOLOGICAL: VXCO-100
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Single Ascending Dose and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of VBP15 in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: VBP15|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy
Status: RECRUITING
Conditions: Neuroendocrine Tumors|Colorectal Cancer|Gastric Cancer
Interventions: BIOLOGICAL: CHM-2101 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Strategies for the Management of Atrial Fibrillation After Cardiac Surgery
Status: UNKNOWN
Conditions: Atrial Fibrillation|Cardiac Surgery
Interventions: DRUG: Landiolol|DRUG: Amiodarone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose Study of BIIB037 in Participants With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: BIIB037|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Diprospan Injection to the Knee on Rehabilitation of Patients After TKR of the Contralateral Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Betamethasone|DRUG: Bupivocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab With or Without Tamoxifen in Treating Women With Progressive Stage IV Breast Cancer
Status: WITHDRAWN
Conditions: Stage IV Breast Cancer|Recurrent Breast Cancer
Interventions: DRUG: tamoxifen|DRUG: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate After Stereotactic Radiosurgery in Treating Patients With Newly Diagnosed Brain Metastases
Status: TERMINATED
Conditions: Cognitive/Functional Effects|Metastatic Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: sunitinib malate|OTHER: cognitive assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differential Effect of High (200μg/kg/Min) Adenosine Dose on Fractional Flow Reserve in Patients Presenting Variation of FFR ≥0.05 During the Usual Dose of Adenosine Infusion (140μg/kg/Min).
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Adenosine infusion at 200μg/Kg/min
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Prospective Trial of Vaccine Responses Against Pneumococcus and Influenza in Adult Cancer Patients 65 Years of Age and Older
Status: COMPLETED
Conditions: Breast Cancer|Lung Cancer|Prostate Cancer
Interventions: BIOLOGICAL: inactivated influenza vaccine and the 23- valent pneumococcal vaccine|BIOLOGICAL: inactivated influenza vaccine and the PPV23 vaccine (Pneumovax)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: IN.PACT™ AV Access Post-Approval Study (PAS002)
Status: ACTIVE_NOT_RECRUITING
Conditions: Arteriovenous Fistula|Arteriovenous Fistula Stenosis|Arteriovenous Fistula Occlusion|Fistula
Interventions: COMBINATION_PRODUCT: IN.PACT™ AV Drug Coated Balloon (DCB) - Primary Cohort|COMBINATION_PRODUCT: IN.PACT™ AV Drug Coated Balloon (DCB) - Extended Cohort
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery
Status: RECRUITING
Conditions: Low-grade Glioma
Interventions: DRUG: Temozolomide|RADIATION: intensity modulated radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Modulation by Ischemic Pre-conditioning in Healthy Individuals: Intracellular Signalling in Regulatory Cells
Status: COMPLETED
Conditions: Ischemia Reperfusion Injury|Ischaemia Reperfusion Injury
Interventions: DEVICE: Single Cuff Tourniquet 8000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fibrinolysis Compared to Thoracoscopy for Pleural Infection
Status: COMPLETED
Conditions: Pleural Infection|Pleural Diseases
Interventions: OTHER: Medical Thoracoscopy|OTHER: Fibrinolytic Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Color Doppler Analysıs Of Uterin And Intraovarian Blood Flow Before And After Treatment Wıth Cabergoline In Hyperprolactinemic Patients
Status: COMPLETED
Conditions: Adverse Reaction to Other Drugs and Medicines
Interventions: DRUG: cabergoline treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis
Status: WITHDRAWN
Conditions: Cystic Fibrosis|Methicillin-resistant Staphylococcus Aureus
Interventions: DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavioral Therapy and Supportive Psychotherapy for Body Dysmorphic Disorder
Status: COMPLETED
Conditions: Body Dysmorphic Disorder|Obsessive-Compulsive Spectrum Disorder|Anxiety Disorders|Somatoform Disorders
Interventions: BEHAVIORAL: Cognitive Behavioral Therapy|BEHAVIORAL: Supportive Psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mandibular Advancement Device for Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Sleep Apnea|Obstructive Sleep Apnea
Interventions: DEVICE: Mandibular advancement device (activator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Regional Anticoagulation With Citrate in Extended Hemodialysis
Status: SUSPENDED
Conditions: Hemodialysis Complication|Acute Kidney Injury|Anticoagulant Toxicity
Interventions: DRUG: Citrate Anticoagulation Solution|DRUG: Control Group (heparin or continuous saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of Awake Nonresectional Versus Nonawake Resectional Lung Volume Reduction Surgery
Status: COMPLETED
Conditions: Pulmonary Emphysema
Interventions: PROCEDURE: awake nonresectional LVRS|PROCEDURE: Nonawake resectional LVRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Observe the Effect of Sphinx Pose (Salamba Bhujangasana) Among Health Care Providers With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: Sphinx Yoga Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Air-impingement Manipulation to Clear Subglottic Secretion to Prevent VAP in Prolonged Intubated Patients
Status: UNKNOWN
Conditions: Ventilator Associated Pneumonia
Interventions: PROCEDURE: Manual air-impingement operation|PROCEDURE: subglottic secretion drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients
Status: UNKNOWN
Conditions: Hemodynamics|Oxidative Stress|Anesthesia
Interventions: DRUG: midazolam|DRUG: Penehyclidine Hydrochloride Injection|DRUG: Etomidate|DRUG: Propofol|DRUG: Fentanyl|DRUG: Cisatracurium Besilate|DRUG: Remifentanil|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Effect of Aerobic and Resistance Training on Physical, Menstrual and Psychological Health of Adolescent Girls.
Status: RECRUITING
Conditions: Psychological Well-Being
Interventions: OTHER: moderate intensity aerobic training and body weight resistance training|OTHER: moderate intensity aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis
Status: COMPLETED
Conditions: Takayasu's Arteritis|Giant Cell Arteritis
Interventions: DRUG: Abatacept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Canagliflozin in Advanced Renal Disease With MRI Endpoints
Status: RECRUITING
Conditions: ESRD, CKD Stage 4, CKD Stage 5
Interventions: DRUG: Canagliflozin 300Mg Tab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: SSP-002358 (0.1 mg) + PPI|DRUG: SSP-002358 (0.5 mg) + PPI|DRUG: SSP-002358 (2.0 mg) + PPI|DRUG: Placebo + PPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chimney Trial of Parastomal Hernia Prevention
Status: ACTIVE_NOT_RECRUITING
Conditions: Parastomal Hernia|Rectal Adenocarcinoma|Abdominoperineal Resection
Interventions: DEVICE: Intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Transition to Adulthood Through Coaching and Empowerment in Rheumatology
Status: RECRUITING
Conditions: Juvenile Idiopathic Arthritis|Juvenile Rheumatoid Arthritis|Juvenile Dermatomyositis|Juvenile Psoriatic Arthritis|Autoinflammatory Disease|Autoimmune Diseases|Lupus Erythematosus
Interventions: BEHAVIORAL: Transition coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis
Status: RECRUITING
Conditions: AL Amyloidosis
Interventions: PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|PROCEDURE: Bone Marrow Biopsy|DRUG: Bortezomib|PROCEDURE: Computed Tomography|DRUG: Cyclophosphamide|DRUG: Daratumumab and Hyaluronidase-fihj|DRUG: Dexamethasone|PROCEDURE: Echocardiography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Melphalan|PROCEDURE: Positron Emission Tomography|PROCEDURE: Stem Cell Isolation|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: New Industrial Procedures for Achieving a Nutritional Added Value of the Olive Oil. The NUTRAOLEUM Study
Status: UNKNOWN
Conditions: Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Virgin Olive Oil (VOO)|DIETARY_SUPPLEMENT: Optimized High Phenolic Content Oil (OHPCO)|DIETARY_SUPPLEMENT: Functional Olive Oil (FOO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Hepatitis C Virus (HCV) Polymerase Inhibitor Pro-Drug in Combination With PEGASYS Plus COPEGUS Compared With PEGASYS Plus COPEGUS in Patients With Chronic Hepatitis C Genotype 1 Infection.
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Copegus|DRUG: Pegasys|DRUG: Pegasys|DRUG: RO4588161|DRUG: RO4588161|DRUG: RO4588161
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of NGM395 in Adult Participants
Status: COMPLETED
Conditions: Obesity|NAFLD
Interventions: BIOLOGICAL: NGM395|BIOLOGICAL: NGM395|BIOLOGICAL: NGM395|BIOLOGICAL: NGM395|BIOLOGICAL: NGM395|BIOLOGICAL: NGM395|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor
Status: RECRUITING
Conditions: Brain Tumor|Metastatic Brain Tumor
Interventions: DIAGNOSTIC_TEST: Resting-state functional connectivity MRI|OTHER: Neurocognitive battery with quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Evaluating the Safety and Efficacy of ATG-010 in Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Interventions: DRUG: ATG-010 60 mg, orally, twice weekly, each 4 week (28-day) a cycle
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pertuzumab With High-Dose Trastuzumab for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer (MBC) With Central Nervous System (CNS) Progression Post-Radiotherapy
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Pertuzumab|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Laser Diode Effect on the Kinetics of Orthodontic Tooth Movement (Protocol CINELASER)
Status: COMPLETED
Conditions: Class II Canine|Intermaxillary Strength|Elastics II|Multi Fasteners Orthodontic Treatment
Interventions: DEVICE: (LLLT Low Level Laser Therapy) SiroLaser advance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Naloxone Infusion Rates on the Postoperative Recovery of Patients Undergoing Spine Fusion Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Postoperative Nausea and Vomiting|Scoliosis
Interventions: DRUG: Naloxone|DRUG: Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Demonstration and Video Viewing Education on Metered Dose Inhaler Usage Skills in Asthma Patients
Status: WITHDRAWN
Conditions: Asthma|Patient Education
Interventions: BEHAVIORAL: Demonstration method for the use of the Metered Dose Inhaler|BEHAVIORAL: Video watching method for the use of the Metered Dose Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Protein-Bound Paclitaxel in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Cancer|Gastric Cancer|Breast Cancer|Pancreatic Cancer|Prostate Cancer Metastatic|Colo-rectal Cancer|Solid Tumor|Solid Carcinoma|Solid Carcinoma of Stomach|Cancer of Stomach
Interventions: DRUG: Minnelide™Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Duvelisib Following Chimeric Antigen Receptor T-Cell Therapy
Status: RECRUITING
Conditions: Non-hodgkin Lymphoma|Acute Lymphocytic Leukemia
Interventions: DRUG: Duvelisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAD Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Cavosonstat (N91115) in Healthy Subjects (SNO-9)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Cavosonstat|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Oral Oxytocin on Women's Response to Emotional Stimuli
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: Oral Oxytocin|DRUG: Oral Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Proof of Concept Study of Re-treatment in BRVO With Ranibizumab Guided by OCT
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: Ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Linagliptin (5 mg Administered Orally Once Daily) Over 24 Weeks, in Drug naïve or Previously Treated Type 2 Diabetic Patients With Insufficient Glycaemic Control
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Placebo|DRUG: Linagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: 17 Alfa Hydroxyprogesterone Caproate Versus Natural Progesterone for the Prevention of Preterm Labor
Status: UNKNOWN
Conditions: Pregnancy
Interventions: DRUG: 17 alfa hydroxyprogesterone caproate|DRUG: natural progesterone|DRUG: 17 alfa hydroxyprogesterone caproate|DRUG: vaginal progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interactive Intention-Driven Upper-Limb Training Robotic System
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Hand Robotic Training|DEVICE: Hand and Arm Robotic Training|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sofosbuvir/Simeprevir Plus a Flat Dose of Ribavirin in Genotype 1 Elderly HCV Cirrhotic Patients
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: DRUG: Sofosbuvir 400mg/day/Simeprevir 150mg/day /Ribavirin 800mg/day for 12 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A PET Study Examining Pharmacokinetics and Dopamine Transporter Receptor Occupancy Of Two Long-Acting Formulations of Methylphenidate in Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: OROS methylphenidate hydrochloride|DRUG: methylphenidate hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)
Status: UNKNOWN
Conditions: Pain, Postoperative|Cardiac Surgery
Interventions: DRUG: LRA Loco-regional anesthesia|PROCEDURE: Standardized post-operative analgesia protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Chemotherapy Guided by the Detection of DNA in Peritoneal Lavage Fluid in Patients With Gastric Cancer
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Intraperitoneal chemotherapy|DRUG: Adjuvant systemic chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cachexia in Gynecological Cancer and the Preventive Role of Weight Training
Status: COMPLETED
Conditions: Breast Cancer Female|Gynecologic Cancer|Menopause|Physical Activity
Interventions: OTHER: Combined training|OTHER: High intensity interval training with body weight
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: FGF401 in HCC and Solid Tumors Characterized by Positive FGFR4 and KLB Expression
Status: COMPLETED
Conditions: Hepatocellular Carcinoma (HCC)|Solid Malignancies
Interventions: DRUG: FGF401|BIOLOGICAL: PDR001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Outcomes and Patient Satisfaction With Bilateral PanOptix Verses Bilateral Synergy
Status: RECRUITING
Conditions: Pseudophakia
Interventions: DIAGNOSTIC_TEST: Visual Acuity|DIAGNOSTIC_TEST: Defocus Curve|DIAGNOSTIC_TEST: Halo and Glare testing|OTHER: Patient Questionnaires
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Symptom Benefit Rate of Trabectedin/PLD in Patients With Recurrent Ovarian Cancer
Status: TERMINATED
Conditions: Recurrent Ovarian Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Gemcitabine|DRUG: Bevacizumab|DRUG: PLD|DRUG: Paclitaxel|DRUG: PLD|DRUG: Trabectedin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate 3 Dose Levels of Luvadaxistat of Adults With Negative Symptoms of Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Luvadaxistat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction
Status: RECRUITING
Conditions: Blasts More Than 5 Percent of Bone Marrow Nucleated Cells|Persistent Disease|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Liposome-encapsulated Daunorubicin-Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Osteopathic Treatment With Cognitive Training on Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: OTHER: osteopathic treatment + cognitive training|OTHER: osteopathic treatment|OTHER: usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Performance and Safety of the Pneumoscope Device in Adults and Children
Status: RECRUITING
Conditions: Respiratory Diseases|Pneumonia|Asthma|Cyanotic Heart Disease
Interventions: DEVICE: Digital lung auscultation|DEVICE: Pulse oximetry measurement|DEVICE: Non invasive body temperature measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Home-Based Program to Help Parents of Drug Abusing Adolescents
Status: COMPLETED
Conditions: Substance-Related Disorders|Drug Addiction|Substance Abuse
Interventions: BEHAVIORAL: Home-Based Intervention|BEHAVIORAL: Educational Group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidisciplinary Evaluation of Elderly Patients With Digestive Cancer (EPODIG-G)
Status: RECRUITING
Conditions: Digestive System Disease|Neoplasms
Interventions: OTHER: EPODIG-G program (coordination of supportive care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Polygenic Risk Score
Interventions: OTHER: Polygenic Risk Score (PRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Determine the Safety of PEP005 0.025% and 0.05% Topical Gel in Patients With Actinic Keratoses
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: PEP005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease
Status: NOT_YET_RECRUITING
Conditions: Ventricular Tachycardia|Cardiomyopathies|Arrhythmias, Cardiac|Ventricular Arrythmia
Interventions: RADIATION: SBRT|PROCEDURE: CA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Utility of Fallopian Tube Cocultures in Assisted Reproductive Technology
Status: WITHDRAWN
Conditions: Infertility
Interventions: PROCEDURE: Laparoscopic Surgery (Biopsies of fallopian tube lumen) using a laparoscopic brush/biopsy device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Intervention With Fluoxetine in Autism
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: DRUG: Fluoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Baby-Feed Web Application for Infant Caregivers to Improve Diets and Weight Gain
Status: RECRUITING
Conditions: Obesity, Childhood
Interventions: BEHAVIORAL: Baby-Feed|BEHAVIORAL: Limited access to the Baby-Feed web application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION