pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Efficacy of Multimodal Analgesia Following Hip Arthroscopy
Status: COMPLETED
Conditions: Hip Pain Chronic
Interventions: DRUG: Zopiclone|DRUG: Gabapentin|DRUG: Celebrex|DRUG: Percocet|DRUG: Naprosyn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ga-68 PSMA Ligand: A Radiopharmaceutical for Localization of Prostate Cancer
Status: COMPLETED
Conditions: Latent Cancer Prostate
Interventions: DRUG: Ga-68 PSMA ligand
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL)
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab|DRUG: Dexamthasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Irvingia Gabonensis Administration on Metabolic Syndrome, Insulin Secretion and Insulin Sensitivity
Status: COMPLETED
Conditions: Metabolic Syndrome X
Interventions: DIETARY_SUPPLEMENT: Irvingia gabonensis|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Preliminary Efficacy and Pharmacokinetics of ASN001 in Metastatic Castrate Resistant Prostate Cancer
Status: TERMINATED
Conditions: Cancer of the Prostate|Neoplasms, Prostate|Prostate Cancer|Prostatic Cancer|Neoplasms, Prostatic|Prostate Neoplasms, Castration-resistant
Interventions: DRUG: ASN001: Escalating dose Part A
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
Status: COMPLETED
Conditions: Syncope, Vasovagal|Pain Intensity
Interventions: DRUG: Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Two Conservative Treatments in Teres Major in Handball Athletes With Shoulder Pain
Status: COMPLETED
Conditions: Shoulder Pain|Dry Needling|Diacutaneous Fibrolysis|Athletic Injuries
Interventions: OTHER: Diacutaneous Fibrolysis|OTHER: Dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Milk Polar Lipids on Lipids Digestion, Absorption and Metabolism
Status: COMPLETED
Conditions: Cardiometabolic Risk
Interventions: OTHER: Cheese n°1- cheese n°2 - cheese n°3|OTHER: Cheese n°1- cheese n°3 - cheese n°2|OTHER: cheese n°2 - cheese n°1- cheese n°3|OTHER: Cheese n°2- cheese n°3 - cheese n°1|OTHER: Cheese n°3 - cheese n°1- cheese n°2|OTHER: Cheese n°3- cheese n°2 - cheese n°1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Head-to-head Study of Erenumab Against Topiramate in Patients With Episodic and Chronic Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: BIOLOGICAL: Erenumab|DRUG: Topiramate|BIOLOGICAL: Erenumab matching placebo|DRUG: Topiramate matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Partial Breast Irradiation (PBI) Using 40 Gy for Select Patients With Early Invasive or Noninvasive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: multiple beams utilizing either intensity-modulated or 3D-conformal techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Sofosbuvir (SOF) and GS-5816 for People With Chronic Hepatitis C Virus Infection and Recent Injection Drug Use
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Sofosbuvir (SOF)/GS-5816
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crossover Bioequivalence Study of Irbesartan HCTZ 300/25 mg Tablets Under Fasted Conditions
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Irbesartan and Hydrochlorothiazide|DRUG: Avalide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis
Status: UNKNOWN
Conditions: Associated Pulmonary Arterial Hypertension
Interventions: DRUG: Sildenafil 20mg and Bosentan 62.5mg|DRUG: Sildenafil 20mg and Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis Lesions
Status: COMPLETED
Conditions: Magnetic Resonance Imaging|Central Nervous System|Brain|Multiple Sclerosis|Demyelinating Diseases
Interventions: DEVICE: Additional MRI sequences
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: ALX-0600|DRUG: placebo|DRUG: teduglutide 0.05|DRUG: teduglutide 0.2 mg|DRUG: Teduglutide 0.05 dose|DRUG: teduglutide 0.1 mg dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HS-10516 in Patients With VHL Syndrome Associated Tumors
Status: RECRUITING
Conditions: Von Hippel Lindau-Deficient Clear Cell Renal Cell Carcinoma
Interventions: DRUG: Oral HS-10516
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Transcranial Random Noise Stimulation on Motor Learning in Typically Developing Adolescents
Status: NOT_YET_RECRUITING
Conditions: Children
Interventions: DEVICE: transcranial random noise stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Right Ventricular Pacemaker Lead Position Assessed by MRI
Status: UNKNOWN
Conditions: Late Complication From Cardiac Pacemaker Implantation
Interventions: OTHER: RVAP|OTHER: RVSP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of mOPV1 in Routine Immunization in Pakistan.
Status: UNKNOWN
Conditions: Oral Polio Vaccine
Interventions: BIOLOGICAL: mOPV|BIOLOGICAL: bOPV|BIOLOGICAL: Full dose IPV|BIOLOGICAL: fractional IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Intermittent or Continuous Panitumumab Plus FOLFIRI for RAS/B-RAF Wild-type Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer Stage IV
Interventions: DRUG: Panitumumab|DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rate of Infection After Using Antibiotic Loaded Cement and Regular Cement in Total Knee Arthroplasty
Status: NOT_YET_RECRUITING
Conditions: Primary Osteoarthritis of Knee Nos
Interventions: PROCEDURE: using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Sequential Treatment Trial of Single Agent Nivolumab, Then Combination Ipilimumab + Nivolumab in Metastatic or Unresectable Non-Clear Cell Renal Cell Carcinoma (ANZUP1602)
Status: UNKNOWN
Conditions: Renal Cell Carcinoma|Papillary Renal Cell Carcinoma Type 1|Papillary Renal Cell Carcinoma Type 2|Chromophobe Renal Cell Carcinoma|Sarcomatoid Renal Cell Carcinoma|Xp11 Translocation Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of Itraconazole on JNJ-56136379 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-56136379|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Compare the Pharmacokinetic Characteristics of CJ-12420
Status: COMPLETED
Conditions: Erosive Esophagitis
Interventions: DRUG: CJ-12420 formulation 2|DRUG: CJ-12420 formulation 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Study of NPB-01 in Patients With Autoimmune Encephalitis
Status: RECRUITING
Conditions: Autoimmune Encephalitis
Interventions: DRUG: NPB-01|DRUG: NPB-01-ME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Training With Custom-Made Biomechanical Perturbation Platform on Kinetics, Kinematics and Electromyography in Knee Osteoarthritis Patients
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: : APOS biomechanical gait system, Apos - Sports and Medical Technologies Ltd. Hertzlia, Israel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donepezil for Oxaliplatin-induced Neuropathy Peripheral Neuropathy: Proof of Concept Study
Status: COMPLETED
Conditions: Digestive Oncology|Supportive Care
Interventions: DRUG: DONEPEZIL|DRUG: PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Association Between STarT Back Tool Subgroups and Postural Stability
Status: COMPLETED
Conditions: Low Back Pain, Postural
Interventions: DIAGNOSTIC_TEST: Static balance testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function
Status: COMPLETED
Conditions: Endothelial Dysfunction
Interventions: DIETARY_SUPPLEMENT: Watermelon Juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Attention Training or SSRIs on Symptoms and Neural Activation in Social Anxiety
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: BEHAVIORAL: Gaze Contingent Music Reward Therapy|DRUG: Escitalopram|BEHAVIORAL: Waitlist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VIRTUUS Children's Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Transplant Rejection|Pediatric Kidney Disease|End Stage Renal Disease|Nephropathy|BK Virus (Nephropathy)|Antibody-mediated Rejection|Acute Cellular Graft Rejection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study To Evaluate The Safety And Efficacy Of The MyEllevate® Procedure
Status: COMPLETED
Conditions: Soft Tissue Approximation|Elevation of Subdermis|Elevation of Underlying Muscle
Interventions: DEVICE: MyEllevate Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK/PD Biosimilarity Study of Gan & Lee Insulin Lispro Injection vs. EU and US Humalog® in Healthy Males
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Gan & Lee Insulin Lispro Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Radiographic and Clinical Outcomes of Robotic-Arm-Assisted Versus Conventional TKA
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Robotic
Interventions: PROCEDURE: robotic system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoradiation and Radiosurgery Boost in Treating Patients With Locally Advance Pancreatic Cancer That May or May Not be Removed by Surgery
Status: TERMINATED
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer
Interventions: DRUG: gemcitabine hydrochloride|RADIATION: hyperfractionated radiation therapy|RADIATION: intensity-modulated radiation therapy|RADIATION: radiosurgery|PROCEDURE: diffusion-weighted magnetic resonance imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Clinical Trial Comparing Treatment With Allogeneic Mesenchymal Cells Versus Autologous Mesenchymal Cells and Versus Active Control With Hyaluronic Acid in Patients With Knee Osteoarthritis.
Status: ACTIVE_NOT_RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Autologous MSCs|DRUG: Allogenic MSCs|DRUG: Hyaluronic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Between the Effect of Diclofanic and Ketorolac in Post Tonsillectomy Pain Management
Status: COMPLETED
Conditions: Pain, Acute
Interventions: DRUG: diclofenac|DRUG: ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Abutment Shape on Peri-implant Marginal Bone Loss
Status: COMPLETED
Conditions: Dental Implant|Bone Resorption
Interventions: PROCEDURE: Commercially available high abutments placement|PROCEDURE: Modified shape abutments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Taxotere Prostate Cancer New Indication Registration Trial in China
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: Docetaxel|DRUG: Mitoxantrone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Durability of Protection After Single Immunisation With GA2 Sporozoites (CoGA-Rechallenge)
Status: NOT_YET_RECRUITING
Conditions: Malaria,Falciparum
Interventions: BIOLOGICAL: CHMI with 3D7 malaria
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Comfort of a Continuous Positive Airway Pressure Nasal Mask in the Treatment of OSA Syndrome
Status: COMPLETED
Conditions: Apnea, Obstructive
Interventions: OTHER: Self-questionnaire on the comfort and general appreciation of a nasal mask|OTHER: Self-questionnaire on the appearance of CPAP side effects related to the mask|OTHER: Self-questionnaire on the patient's appreciation of the mask headgear,|OTHER: Self-questionnaire NOSE on the discomfort caused by the nasal obstruction|OTHER: Self-questionnaire Epworth on the daytime sleepiness|OTHER: To study the CPAP compliance|OTHER: To study the unintentional leakage|OTHER: To study the therapeutic pressures of CPAP
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Midazolam Premedication on Copeptine Concentration in Blood
Status: COMPLETED
Conditions: Preanesthetic Medication|Copeptin
Interventions: DRUG: Midazolam Oral Tablet|OTHER: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the Impact of Welding Fumes on the Arterial System : RISCAS Study
Status: TERMINATED
Conditions: Effects of Welding Fumes Components
Interventions: DIAGNOSTIC_TEST: Laser doppler, blood tests, and holter ECG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cocoa/Carob Polyphenols and Postprandial Changes in Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: OTHER: No product (A)/mixture of coca and carob together with breakfast (B)/mixture of coca and carob 10 h before breakfast (C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Lurbinectedin as Single-agent or in Combination With Irinotecan Versus Topotecan or Irinotecan in Patients With Relapsed Small-cell Lung Cancer (LAGOON)
Status: RECRUITING
Conditions: Relapsed Small Cell Lung Cancer
Interventions: DRUG: Irinotecan|DRUG: Lurbinectedin|DRUG: Irinotecan|DRUG: Topotecan|DRUG: Lurbinectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Suprazygomatic Maxillary Nerve Block as A Part of Multimodal Analgesic Regimens
Status: UNKNOWN
Conditions: Suprazygomatic Maxillary Nerve Block
Interventions: OTHER: UG-SZM Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Explore The Potential For PF-04531083 To Effect The Blood Concentrations Of Simvastatin And Its Main Acid Metabolite Following Co-Administration Of Both Medications
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DRUG: PF-04531083|DRUG: simvastatin|DRUG: PF-04531083|DRUG: simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety of Injection With VINCI Plus Hyaluronic Acid Filler
Status: COMPLETED
Conditions: Nasolabial Fold Improvement
Interventions: DEVICE: VINCI Plus|DEVICE: Restylane-L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of SP-2577 Plus Pembrolizumab in Select Gynecologic Cancers
Status: WITHDRAWN
Conditions: SCCOHT|Ovarian Clear Cell Tumor|Ovarian Endometrioid Adenocarcinoma|Endometrial Cancer
Interventions: DRUG: SP-2577|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cholic Acid for Hepatic Steatosis in Lipodystrophy
Status: COMPLETED
Conditions: Hepatic Steatosis
Interventions: DRUG: Cholic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
Status: UNKNOWN
Conditions: Airway Remodeling
Interventions: DRUG: Tiotropium Inhalation Powder [Spiriva] 0.018mg|DRUG: Salbutamol sulphate aerosol (Ventolin) 0.01mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: DRUG: dalcetrapib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Find the Best Formulation of BI 894416 and to Test How This is Taken up in the Body
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: BI 894416 - Formulation A2|DRUG: BI 894416 - Formulation C2|DRUG: BI 894416 - Formulation D2|DRUG: BI 894416 - Formulation F2|DRUG: BI 894416 - Reference Formulation 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Best Clinical Endpoints That Likely Induce Worse Prognosis in Interstitial Lung Diseases
Status: UNKNOWN
Conditions: Interstitial Lung Disease
Interventions: DIAGNOSTIC_TEST: Daily physical activity levels|DIAGNOSTIC_TEST: 6-minute walk test|DIAGNOSTIC_TEST: Cardiopulmonary exercise testing|DIAGNOSTIC_TEST: Muscle Function|DIAGNOSTIC_TEST: Lung Function|DIAGNOSTIC_TEST: Body composition|DIAGNOSTIC_TEST: HRQoL - SGRQ-I|DIAGNOSTIC_TEST: Symptoms - UCSD/SOBQ|DIAGNOSTIC_TEST: HRQoL - SF36|DIAGNOSTIC_TEST: Anxiety and depression|DIAGNOSTIC_TEST: Symptoms - mMRC|DIAGNOSTIC_TEST: Sleep quality|DIAGNOSTIC_TEST: Sleepiness|DIAGNOSTIC_TEST: Inflammatory markers and oxidative stress|DIAGNOSTIC_TEST: Functional performance tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PD-1 Antibody(SHR-1210) Plus Apatinib Combined With POF in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Advanced Gastric Adenocarcinoma
Interventions: DRUG: Camrelizumab|DRUG: Apatinib Mesylate|DRUG: POF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of GS-9219 in Chronic Lymphocytic Leukemia (CLL), Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM)
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|Chronic Lymphocytic Leukemia|Multiple Myeloma
Interventions: DRUG: GS-9219
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anesthetic Efficacy of 1.8 ml Versus 3.6 ml of 4% Articaine Buccal Infiltration
Status: NOT_YET_RECRUITING
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: 3.6 ml 4% Articaine hydrochloride|DRUG: 1.8 ml 4% Articaine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction
Status: COMPLETED
Conditions: Pain, Post-operative|Third Molar|Oral Surgery|Pain, Acute
Interventions: DRUG: Ketorolac|DRUG: Oxycodone|DRUG: Acetaminophen|DRUG: Ibuprofen|DRUG: Hydrocodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lot-to-Lot Consistency Study of the Investigational, Inactivated, Split-Virion Influenza Vaccine in Adults
Status: COMPLETED
Conditions: Orthomyxoviridae Infection|Influenza|Myxovirus Infection
Interventions: BIOLOGICAL: Inactivated Split-virion influenza vaccine|BIOLOGICAL: Inactivated Split-virion influenza vaccine|BIOLOGICAL: Inactivated Split-virion influenza vaccine|BIOLOGICAL: Inactivated Split-virion influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Investigating the Levels and Effects of Low-grade Inflammation in Diabetic Retinopathy of Type 1 Diabetes
Status: TERMINATED
Conditions: Diabetic Retinopathy|Inflammation
Interventions: PROCEDURE: Blood sampling|PROCEDURE: Noninvasive measurement of systemic hemodynamics|PROCEDURE: Visual acuity assessment|DEVICE: Blue field entoptic technique (Blue field stimulator, BFS-2050)|PROCEDURE: Ophthalmic examination and fundus photography|DEVICE: Retinal Vessel Analyzer (DVA)|DEVICE: High resolution optical coherence tomography (OCT)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the Efficacy of a Dietary Supplement on Hair Loss and Hair Aspect
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Wheat Polar Lipid Complex|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3295668 Erbumine in Participants With Breast Cancer That Has Spread to Other Parts of the Body
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: LY3295668 Erbumine|DRUG: Endocrine therapy|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tesevatinib Monotherapy in Patients With Recurrent Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|Recurrent Glioblastoma|Brain Tumor
Interventions: DRUG: Tesevatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-Carbamylated Protein Antibodies in Psoriatic Arthritis
Status: COMPLETED
Conditions: Psoriasis|Arthritis, Psoriatic
Interventions: DIAGNOSTIC_TEST: Serum anti-CarP antibodies detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Non-inferiority, Multicenter and Randomized, Single-Dose Study About a Treatment to Hypolactasia (LAILAI)
Status: COMPLETED
Conditions: Hypolactasia
Interventions: DRUG: Lactase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In-vivo Extraction of Pb, Cd andTSNA From Swedish Snus
Status: COMPLETED
Conditions: Smoking Cessation|Smokeless Tobacco|Harm Reduction
Interventions: PROCEDURE: Buccal Administration of nicotine|PROCEDURE: Buccal Administration of nicotine|PROCEDURE: Buccal Administration of nicotine|PROCEDURE: Buccal Administration of nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: D-Dimer-based Indication for Transesophageal Echocardiography to Exclude Left Atrial Thrombus Before Cardioversion of Non-anticoagulated Atrial Fibrillation: A Multicenter Belgian Study
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DIAGNOSTIC_TEST: Transesophageal echocardiography|DIAGNOSTIC_TEST: D-Dimer analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Expiratory Flow Accelerator (Efa) vs Efa + High Flow in Chronic COPD and Bronchiectasis
Status: RECRUITING
Conditions: Copd|Bronchiectasis Adult
Interventions: DEVICE: Bronchial Clearance A|DEVICE: Bronchial Clearance B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: European Home Mechanical Ventilation Registry
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive|Amyotrophic Lateral Sclerosis|Spinal Cord Injury|Muscular Dystrophies|Obesity Hypoventilation Syndrome|Kyphoscoliosis|Congenital Central Hypoventilation Syndrome|Duchenne Muscular Dystrophy|Myopathies|Myotonic Dystrophy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Restylane® Skinboosters™ Vital in the décolletage Region
Status: COMPLETED
Conditions: Decolletage Rejuvenation
Interventions: DEVICE: Restylane® Skinboosters™ Vital (SBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers
Status: COMPLETED
Conditions: Nicotine Dependence|Nicotine Dependence, Cigarettes|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Tobacco flavored JUUL 1.7% ENDS|OTHER: Tobacco flavored JUUL 5% ENDS|OTHER: Mint flavored JUUL 1.7% ENDS|OTHER: Mint flavored JUUL 5% ENDS|OTHER: Fruit Medley flavored JUUL 1.7% ENDS|OTHER: Fruit Medley flavored JUUL 5% ENDS|OTHER: Crème brulee flavored JUUL 1.7% ENDS|OTHER: Crème brulee flavored JUUL 5% ENDS|OTHER: JUUL 1.7% ENDS 10 puffs vs. ad lib puffs|OTHER: JUUL 5% ENDS 10 puffs vs. ad lib puffs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Doxepin and a Topical Rinse in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Radiotherapy With or Without Chemotherapy
Status: COMPLETED
Conditions: Acute Oral Mucositis Pain
Interventions: DRUG: doxepin hydrochloride oral solution|DRUG: DLA (diphenhydramine, lidocaine and antacids) rinse|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock
Interventions: DRUG: sodium-selenite|DRUG: Placebo|PROCEDURE: Procalcitonin guided therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Accelerate Immune System Recovery Following Stem Cell Transplantation
Status: TERMINATED
Conditions: ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
Interventions: DRUG: L-leucyl-L-leucine methyl ester (LLME)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fiix-prothrombin Time for Monitoring Warfarin
Status: COMPLETED
Conditions: Thromboembolism|Arterial|Venous
Interventions: DEVICE: Fiix prothrombin time
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using of Collagen Matrix for Maxillary Tuberosity Donor Area Preservation
Status: RECRUITING
Conditions: Soft Tissue Atrophy
Interventions: PROCEDURE: Closure of the donor area after CTG harvesting without the use of collagen matrix|PROCEDURE: Closure of the donor area after CTG harvesting with collagen matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cervix:Hypoxia, Interstitial Fluid Pressure and GSH Levels
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervix Neoplasms
Interventions: PROCEDURE: Pre-treatment tumour oxygen measurements (under anesthesia)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Analysis of Extraperitoneal Rectal Neoplasms Between 3D Endorectal Ultrasonography and Magnification Chromoendoscopy
Status: UNKNOWN
Conditions: Rectal Cancer|Rectal Cancer Stage I
Interventions: PROCEDURE: three-dimensional endorectal ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Motivational Interviewing on Self-Efficacy and Quality of Life in Gestational Diabetes Mellitus
Status: RECRUITING
Conditions: Motivational Interviewing|Self Efficacy|Quality of Life|Gestational Diabetes Mellitus
Interventions: BEHAVIORAL: Motivational Interview to Increase Health Management Self-Efficacy and Quality of Life in Pregnant Women Diagnosed with Gestational Diabetes Mellitus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetics and Pharmacodynamics of RPH-104 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: RPH-104|OTHER: Sodium chloride Sterile Injection 0.9% w/v
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: To Demonstrate That Lactobacillus Reuteri ATCC PTA 4659 Survives Passage Through the Gastrointestinal Tract of Humans
Status: COMPLETED
Conditions: Recovery of Lactobacillus Reuteri ATCC PTA 4659|The Safety of Lactobacillus Reuteri ATCC PTA 4659
Interventions: OTHER: Probiotic strain ATCC PTA 4659
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate RL-007 in the Treatment of Cognitive Impairment Associated With Schizophrenia (CIAS)
Status: RECRUITING
Conditions: Cognitive Impairment Associated With Schizophrenia (CIAS)|Cognitive Impairment|Schizophrenia
Interventions: DRUG: RL-007|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Requirements for Vitamin D in Pregnant Women
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: 10 mcg Vitamin D3|DIETARY_SUPPLEMENT: 20 mcg Vitamin D3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparing CBT-T to CBT-E in Non-low-weight Adults With Eating Disorders
Status: UNKNOWN
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy-Enhanced|BEHAVIORAL: Cognitive Behavioural Therapy-Ten
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HRN 004- Peginterferon a-2a Plus Ribavirin for Chronic Hepatitis C Infection in HIV Infected Persons Who Have Failed to Achieve a Sustained Virologic Response Following Previous Interferon Therapy
Status: UNKNOWN
Conditions: Chronic Hepatitis C Infection in HIV Infected Persons|HIV Infections
Interventions: DRUG: Peginterferon a-2a plus Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Status: COMPLETED
Conditions: Heart Diseases|Cardiovascular Diseases|Acute Myocardial Infarction|Unstable Angina|Chronic Stable Angina|Ischemic Stroke|Cerebrovascular Accident|Subarachnoid Hemorrhage|Transient Ischemic Attack|Abdominal Aortic Aneurysm|Peripheral Arterial Disease|Sudden Coronary Death|Ventricular Arrhythmia|Sudden Death|Cardiac Arrest|Heart Failure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Trial of the Immunogenicity, Safety, and Efficacy of the Gam-COVID-Vac Vaccine Against COVID-19 in Venezuela
Status: UNKNOWN
Conditions: Covid19
Interventions: BIOLOGICAL: Gam-COVID-Vac|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: EVPOME Versus AlloDerm in Subjects Reconstructed With Large Defect Mandibular Resection
Status: TERMINATED
Conditions: Mandibular Injuries
Interventions: BIOLOGICAL: AlloDerm|BIOLOGICAL: EVPOME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perinatal Precision Medicine
Status: ACTIVE_NOT_RECRUITING
Conditions: Genetic Diseases|Genetic Syndrome|Mendelian Disorders
Interventions: GENETIC: Genomic sequencing and molecular diagnostic results, if any.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Sesamin on Sleep Quality and Antioxidative Status
Status: COMPLETED
Conditions: Sleeping Disorders
Interventions: DIETARY_SUPPLEMENT: sesame extract|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Stem Cell Mobilization and VEGF Gene Transfer for Heart Failure
Status: WITHDRAWN
Conditions: Ischemic Congestive Heart Failure (CHF)
Interventions: GENETIC: Vascular Endothelial Growth Factor (VEGF1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Pilot Trial To Assess The Feasibility And Efficacy Of SCIG In Patients With MG Exacerbation (SCIG-MG)
Status: COMPLETED
Conditions: Myasthenia Gravis
Interventions: DRUG: Human normal immunoglobulin G (IgG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare Technegas Ventilation-Perfusion SPECT and Xenon Ventilation-Perfusion Planar Imaging for Pulmonary Embolism
Status: TERMINATED
Conditions: Pulmonary Embolism
Interventions: DRUG: Technegas V SPECT imaging|DRUG: Xenon-133 Ventilation Planar imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Nationwide Utilization of Danish Government Electronic Letter System for Increasing InFLUenza Vaccine Uptake Among Adults With Chronic Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza|Behavior and Behavior Mechanisms
Interventions: BEHAVIORAL: Behavioral Economic Principles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neurally Adjusted Ventilatory Assist (NAVA) in Pediatric Patients
Status: COMPLETED
Conditions: Ventilation
Interventions: DEVICE: Neurally adjusted ventilatory assist, i-Servo, Maquet Nordic (Solna, Sweden)|DEVICE: Control (PC- or PRVC- ventilation), i-Servo, Maquet Nordic (Solna, Sweden)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of the Fixed Dose Combination of 5 mg Saxagliptin and 500 mg Metformin XR Tablet (Manufactured in Mt Vernon, IN) Relative to 5 mg Saxagliptin Tablet and 500 mg Metformin XR Tablet (Manufactured in Evansville, IN)
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: saxagliptin|DRUG: metformin XR|DRUG: saxagliptin + metformin XR (FDC tablet)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: POISE Trial: Perioperative Ischemic Evaluation Study
Status: TERMINATED
Conditions: Cardiovascular Diseases
Interventions: DRUG: Metoprolol controlled release (CR)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: AM vs PM Exercise Training
Status: RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: 6 weeks of exercise training (Pre-training)|BEHAVIORAL: 6 weeks of exercise training (Post-training)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Treatment of Ulcerative Colitis With Trichuris Suis Ova (TSO)
Status: COMPLETED
Conditions: Ulcerative Colitis Chronic Moderate
Interventions: BIOLOGICAL: Trichuris suis ova|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of MICRORAPTOR™ Suture Anchors in Shoulder and Hip
Status: ACTIVE_NOT_RECRUITING
Conditions: Labral Tear, Glenoid|Acetabular Labrum Tear|Bankart Lesions|Anterior Shoulder Instability|SLAP Lesion|Rotator Cuff Tears
Interventions: DEVICE: MICRORAPTOR™ REGENESORB™ Suture Anchor|DEVICE: MICRORAPTOR™ Knotless REGENESORB™ Suture Anchor|DEVICE: MICRORAPTOR™ Knotless PEEK Suture Anchor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gemcitabine Plus Docetaxel or Irinotecan in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: docetaxel|DRUG: gemcitabine hydrochloride|DRUG: irinotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing and Understanding Freezing of Gait at Home: FOG@Home
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Freezing of Gait
Interventions: DEVICE: AX6 6-axis logging accelerometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral Component
Status: COMPLETED
Conditions: Avascular Necrosis of Hip|Osteoarthritis, Hip|Rheumatoid Arthritis|Inflammatory Arthritis|Post-traumatic; Arthrosis
Interventions: DIAGNOSTIC_TEST: Serum Metal ion levels determined to monitor changes in chromium and cobalt levels
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appetite Response to Exercise- Versus Mixed (Exercise + Dietary Restriction)-Induced Energy Deficit in Adolescents With Obesity
Status: COMPLETED
Conditions: Pediatric Obesity
Interventions: BEHAVIORAL: CON . control condition without exercise / rest condition|BEHAVIORAL: Def-Mixed. Condition with a mixed energy deficit induced by exercise + dietary restriction.|BEHAVIORAL: Def-EI. Condition with an energy-restriction energy deficit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Type of Bioabsorbable Screw in the Hallux Valgus Surgery
Status: UNKNOWN
Conditions: Hallux Valgus|Hallux Rigidus
Interventions: PROCEDURE: surgery, bioabsorbable screw
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Diagnostic Value of PET/MRI in Head and Neck Cancer
Status: UNKNOWN
Conditions: Squamous Cell Carcinoma of Head and Neck|Head and Neck Neoplasms|Lymph Node Metastases
Interventions: DIAGNOSTIC_TEST: PET/MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial
Status: COMPLETED
Conditions: End Stage Renal Failure on Dialysis
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thromboelastography Guided Blood Product Transfusion for Upper Gastrointestinal Bleeding in Cirrhosis
Status: WITHDRAWN
Conditions: Cirrhosis, Liver|Coagulopathy|GastroIntestinal Bleeding
Interventions: DIAGNOSTIC_TEST: Thromboelastography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Fixed PC Interval Using SMS for Afternoon Colonoscopy
Status: COMPLETED
Conditions: Effectiveness of SMS to Fix PC Interval
Interventions: BEHAVIORAL: Short message service of mobile phone (SMS)|DRUG: polyethylene glycol (PEG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Efficacy and Safety of the Combination of Valsartan Plus Amlodipine in Hypertensive Patients Not Adequately Responding to the Combination Therapy With Ramipril Plus Felodipine
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: valsartan + amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT141 in Patients With Unresectable or Metastatic CLDN18.2-positive Gastric, Pancreatic, Ovarian and Biliary Tract Tumors
Status: TERMINATED
Conditions: Solid Tumor|Gastric Cancer|Gastroesophageal Junction Adenocarcinoma|Esophageal Adenocarcinoma|Pancreatic Cancer|Biliary Tract Cancer|Cholangiocarcinoma|Metastatic Cancer
Interventions: BIOLOGICAL: BNT141|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT