pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Leronlimab in Moderately Ill Patients With COVID-19 Pneumonia
Status: SUSPENDED
Conditions: COVID-19 Pneumonia
Interventions: DRUG: Leronlimab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study Using Negative Pressure Dressing With & Without Silver Alginate to Promote Healing in Chronic Wounds.
Status: COMPLETED
Conditions: Wound Healing
Interventions: OTHER: silver alginate|OTHER: VAC dressing without silver alginate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Multicentre Prospective Clinical Database for the Construction of Predictive Models on Risk of Intrauterine Adhesion
Status: RECRUITING
Conditions: Database for Intrauterine Adhesion|Risk Factors for Intrauterine Adhesion|Risk Stratification and Prognostic Assessment|Intrauterine Adhesion
Interventions: DIAGNOSTIC_TEST: Hysteroscopy|DIAGNOSTIC_TEST: Ultrasonography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trabectedin/Caelyx vs Cisplatin Hypersensitivity in Relapsed Ovarian Cancer Patients Allergic to Platinum
Status: COMPLETED
Conditions: Ovarian Neoplasm|Chemotherapeutic Toxicity|Chemotherapy Effect|Chemotherapy-induced Neutropenia|Chemotherapy-induced Nausea and Vomiting
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Predict to Prevent Frontotemporal Lobar Degeneration (FDT) and Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Frontotemporal Lobar Degeneration|Amyotrophic Lateral Sclerosis
Interventions: BEHAVIORAL: characterization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Efficacy of Lycium Barbarum Polysaccharide in Patients With Major Depressive Disorder
Status: UNKNOWN
Conditions: Major Depressive Disorder|Depression|Depressive Disorder
Interventions: DIETARY_SUPPLEMENT: Lycium barbarum polysaccharide|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY900014 and Insulin Degludec in Participants With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: LY900014|DRUG: Insulin Degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimization of Blood Pressure Management After Acute Ischemic Stroke and Its Prognostic Significance
Status: COMPLETED
Conditions: Ischemic Stroke|Hypertension
Interventions: BEHAVIORAL: Behavioral intensification|DRUG: Pharmacological intensification based on olmesartan|DEVICE: Bluetooth-equipped sphygmomanometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omalizumab Use and Asthma-Related Quality of Life in Patients With Severe Persistent Allergic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Omalizumab|DRUG: Inhaled corticosteroids (ICS)|DRUG: Long-acting beta 2-adrenergic agonist (LABA)|DRUG: Short-acting beta 2-adrenergic agonist (SABA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Stimulus-response Potentiation in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DIAGNOSTIC_TEST: Auditory High Frequency Tetanizing Stimulation|DIAGNOSTIC_TEST: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma
Status: COMPLETED
Conditions: Brain Tumor Treated With Cranial or Cranial-Spinal Radiation
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma.
Status: TERMINATED
Conditions: Locally Advanced Metastatic BRAF Mutant Melanoma
Interventions: DRUG: LEE011|DRUG: LGX818
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Extended Use Study of Safety and Efficacy of Talimogene Laherparepvec in Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Talimogene Laherparepvec|DRUG: Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prosthetic Rehabilitation of Thin Wiry Ridge by Ridge Splitting and Simultaneous Implants Placement
Status: COMPLETED
Conditions: Atrophic Maxillary Ridge and Mandibular Ridge
Interventions: OTHER: implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study to Compare Double-dose Betaferon to the Approved Dose, for Patients With Early Secondary Progressive Multiple Sclerosis (SPMS)
Status: WITHDRAWN
Conditions: Multiple Sclerosis
Interventions: DRUG: Interferon beta-1b (Betaferon/Betaseron, BAY86-5046)|DRUG: Interferon beta-1b (Betaferon/Betaseron, BAY86-5046)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A New Class IIb MD in Proctological Disorders
Status: COMPLETED
Conditions: Proctological Disorders
Interventions: DEVICE: Medical device Procto|DEVICE: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dietetic Efficacy of Mare's Milk for Patients With Chronic Inflammatory Bowel Diseases
Status: COMPLETED
Conditions: Ulcerative Colitis|Crohns Disease
Interventions: DIETARY_SUPPLEMENT: mare´s milk|OTHER: placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions: BIOLOGICAL: Aldesleukin|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pembrolizumab|OTHER: Quality-of-Life Assessment|BIOLOGICAL: Therapeutic Tumor Infiltrating Lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Pharmacokinetics and Tolerance of Co-administration of Oral Multiple Dose of Ketoconazole and an IV (Bolus) Infusion of Eribulin in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Eribulin alone|DRUG: Eribulin plus Ketoconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Leadless AV Versus DDD Pacing Study
Status: RECRUITING
Conditions: Cardiac Pacemaker|Arrhythmias, Cardiac|Heart Diseases|Cardiovascular Diseases
Interventions: DEVICE: Conventional pacemaker DDD|DEVICE: Leadless pacemaker Micra AV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Self-advocacy Serious Game Intervention
Status: RECRUITING
Conditions: Self-Management|Quality of Life
Interventions: BEHAVIORAL: Strong Together serious game|BEHAVIORAL: Enhanced Care as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pazopanib (VOTRIENT) Plus Paclitaxel (TAXOL), Pazopanib Plus Paclitaxel (TAXOL) Plus Carboplatin (PARAPLATIN), and Pazopanib Plus Paclitaxel (TAXOL) Plus Lapatinib (TYKERB)
Status: COMPLETED
Conditions: Neoplasms, Breast
Interventions: DRUG: Pazopanib|DRUG: Lapatinib|DRUG: paclitaxel|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of the Safety of MC-1101 in Both Normal Volunteers and Patients With Early Dry AMD
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: MC-1101|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Delayed Secondary Reconstruction of Alveolar Clefts Using Autogenous Symphyseal Particulate Bone Versus Iliac Cancellous Bone: A Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Bone Facial Bone
Interventions: PROCEDURE: alveolar cleft Grafting from the symphysis|PROCEDURE: alveolar cleft Grafting from the iliac cancellous bone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Treprostinil on Right Ventricular Structure and Function in Patients With Pulmonary Arterial Hypertension
Status: RECRUITING
Conditions: Pulmonary Hypertension
Interventions: DRUG: Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Point of Care HbA1c as a Screening Test for Type 2 Diabetes in First Nations
Status: UNKNOWN
Conditions: Type 2 Diabetes
Interventions: PROCEDURE: Point-of-care "finger-poke" HbA1c determination.|PROCEDURE: HbA1c blood test|PROCEDURE: HbA1c finger poke test|PROCEDURE: Blood test|PROCEDURE: Blood test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Are There Differences in Postoperative Pain Between Bupivacaine and Lidocaine for Carpal Tunnel Release?
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome|Carpal Tunnel
Interventions: DRUG: Lidocaine|DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Improving Pain Relief Following Laparoscopic Ventral Hernia Repair
Status: WITHDRAWN
Conditions: Pain, Postoperative|Anesthesia, Local|Hernia, Ventral|Laparoscopy|Analgesics, Opioid|Complications
Interventions: DEVICE: AutoFuser Pain Pump|DRUG: Ropivacaine|OTHER: Normal Saline (0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine
Status: TERMINATED
Conditions: Depressive Disorder|Major Depression|Depression|Depression, Unipolar
Interventions: DRUG: Vortioxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant Therapy in Resectable Non-Small Cell Lung Cancer Stages IIB-IIIB
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: anti-PD-1 or anti-PD-L1|DRUG: EGFR-TKI, ALK inhibitor, ROS1 inhibitor|DRUG: investigator decided
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
Status: COMPLETED
Conditions: Ventilator Associated Pneumonia
Interventions: OTHER: Oral care with 0,12% Chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate the Efficacy and Safety of Ilaprazole 10 mg in Prevention NSAIDs Associated Peptic Ulcer
Status: NOT_YET_RECRUITING
Conditions: Peptic Ulcer
Interventions: DRUG: Ilaprazole|DRUG: Lansoprazole|DRUG: Ilaprazole Placebo|DRUG: Lansoprazole Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combining Afatinib and Concurrent Chemotherapy, Followed by Osimertinib and Concurrent Chemotherapy, in Untreated EGFR Positive NSCLC Tumors
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Afatinib, Osimertinib, Carboplatin and Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Prednisolone in the Treatment of Esophageal Stricture After Esophageal Surgery
Status: UNKNOWN
Conditions: Esophageal Anastomotic Stricture
Interventions: DRUG: Oral Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study on Safety, Tolerance and Metabolic Effects of a Nutritional Supplement, Given as a Drink Before Gallbladder Surgery
Status: COMPLETED
Conditions: Enteral Nutrition Regimen Prior to Surgery
Interventions: DIETARY_SUPPLEMENT: PreOP Booster (oral nutritional supplement, food for special medical purposes)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Auditory Cues on Mood and Gait
Status: UNKNOWN
Conditions: Psychological|Auditory Perception
Interventions: BEHAVIORAL: Negative Reinforcement|BEHAVIORAL: Positive Reinforcement|BEHAVIORAL: Silence|BEHAVIORAL: Music
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Opioid-free Anesthesia With ESPB in VATS Operation
Status: COMPLETED
Conditions: Opioid Use
Interventions: PROCEDURE: Erector spinae plane block (ESPB) technique without opioid use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM)
Status: COMPLETED
Conditions: Varicose Veins
Interventions: DRUG: Polidocanol Endovenous Microfoam (PEM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Pharmacokinetics of Single Doses of ASP2151 in Healthy Male Subjects and the Effects of Food
Status: COMPLETED
Conditions: Herpes Genitalis|Herpes Zoster
Interventions: DRUG: ASP2151|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intermittent Fasting in Dyslipidemia
Status: UNKNOWN
Conditions: Intermittent Fasting|Dyslipidemias|HDL Cholesterol, Low Serum|Hepatic Enzymes and Function Abnormalities|Anemia|Kidney Diseases|Cardiac Function
Interventions: OTHER: Fasting (diet restruction for specific period)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adaptation and Evaluation of a Culturally and Gender Relevant Tobacco Cessation Among Women in Brazil: An Integrated mHealth Approach
Status: RECRUITING
Conditions: Tobacco Cessation
Interventions: BEHAVIORAL: Integrated tobacco cessation intervention delivered by Community Health Workers with the support of an App (mHealth) + Tobacco cessation program at the public health system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Decolonization of Children Hospitalized in Intensive Care Unit
Status: COMPLETED
Conditions: Central Venous Catheter
Interventions: OTHER: Skin microbiological sampling (wash with 2% Chlorhexidine Gluconate)|OTHER: Skin microbiological sampling (wash with mild soap)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Development of Novel Strategy for Treatment of Anterior Cruciate Ligament (ACL) Injury Using Stem Cell
Status: COMPLETED
Conditions: Deficiency of Anterior Cruciate Ligament
Interventions: BIOLOGICAL: Cartistem(TM)|BIOLOGICAL: hyaluronic acid|PROCEDURE: ACL reconstruction only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: GENIFEM Trial: Postoperative Pain After Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Analgesia|Total Knee Arthroplasty
Interventions: PROCEDURE: Genicular nerve block-iPACK group|PROCEDURE: Femoral triangle block-iPACK group|PROCEDURE: Local infiltration analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and n-3 Polyunsaturated Fatty Acids (PUFAs) to Prevent Chronic Pain Following Major Thermal Burn Injury
Status: TERMINATED
Conditions: Chronic Pain Following Thermal Burn Injury
Interventions: DRUG: Omega-3 fatty acids (fish oil)|DRUG: Vitamin D3 (cholecalciferol)|DRUG: Vitamin D3 (cholecalciferol) placebo|DRUG: Omega-3 fatty acid placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Insulin Detemir and NPH Insulin on Renal Handling of Sodium, Fluid Retention, and Weight in Type 2 Diabetic Patients
Status: COMPLETED
Conditions: Diabetes Type 2|Weight Gain
Interventions: DRUG: Insulin Detemir; Insulin Insulatard|DRUG: Insulin Detemir, Insulin Insulatard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dapsone Coronavirus SARS-CoV-2 Trial (DAP-CORONA) COVID-19
Status: UNKNOWN
Conditions: COVID-19
Interventions: DRUG: Dapsone 85 mg PO BID|DRUG: Placebo 85 mg PO BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors of Response to Iron and Erythropoietin Stimulating Agents
Status: COMPLETED
Conditions: Renal Failure Chronic|Anemia
Interventions: DRUG: Iron Sucrose Solution for Injection|DRUG: Epoetin Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Cariprazine|DRUG: Antidepressant Therapy (ADT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study Of Bococizumab (PF-04950615; RN316) In Hypercholesterolemic Japanese Subjects
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Bococizumab (PF-04950615;RN316)|DRUG: Bococizumab (PF-04950615;RN316)|DRUG: Bococizumab (PF-04950615;RN316)|DRUG: Placebo|DRUG: Ezetimibe|DRUG: Bococizumab (PF-04950615;RN316)|DRUG: Bococizumab (PF-04950615;RN316)|DRUG: Bococizumab (PF-04950615;RN316)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Human T Lymphoid Progenitor (HTLP) Injection After Partially HLA Compatible Allogeneic Hematopoietic Stem Cell Transplantation in SCID Patients
Status: RECRUITING
Conditions: Pediatric Patients|Any Type of Severe Combined Immunodeficiency (SCID)|Partial HLA Incompatible Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Interventions: DRUG: Human T Lymphoid Progenitor (HTLP) injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Surgical,Clinical and Oncological Outcomes Between Robotic-assisted and Laparoscopic-assisted Gastrectomy
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Robotic-assisted Gastrectomy(RAG)|PROCEDURE: Laparoscopic-assisted Gastrectomy(LAG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychoeducation for Adults With Autism and Their Significant Others/Family Members
Status: COMPLETED
Conditions: Treatment Satisfaction|Knowledge Acquisition Disability Nos|Anxiety|Depression|Quality of Life|Relation, Family|Acceptance of Diagnosis|Stigma of Mental Illness|Participation
Interventions: BEHAVIORAL: Psychoeducation for Adults With Autism and Their Significant Others/Family members (Prisma)|BEHAVIORAL: Treatment as usual/standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Hydrodissection Between Normal Saline and a Combination of Triamcinolone Acetonide, Normal Saline, and Lidocaine in CTS
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Ultrasound-guided Hydrodissection of the Median Nerve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety of SP-104
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: SP-104|DRUG: Naltrexone immediate release oral capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Status: TERMINATED
Conditions: Infant, Newborn|Hypertension, Pulmonary|Persistent Fetal Circulation Syndrome|Pneumonia, Aspiration|Respiratory Distress Syndrome, Newborn|Respiratory Insufficiency
Interventions: DRUG: Inhaled nitric oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motivational Interviewing to Enhance Adherence of Patients With Psychogenic Non-epileptic Seizures
Status: COMPLETED
Conditions: Psychogenic Non-epileptic Seizures, Motivational Interviewing
Interventions: BEHAVIORAL: motivational interviewing|BEHAVIORAL: standard psychotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 3 Intraocular Lenses Following Lens Extraction
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Crystalens AO|DEVICE: ReSTOR|DEVICE: Tecnis Multifocal IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of Functional Near Infrared Spectroscopy
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: OTHER: acupuncture and moxibustion|DRUG: Fluoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Evaluating the Efficacy of Certolizumab Pegol for Interstitial Cystitis
Status: COMPLETED
Conditions: Cystitis, Interstitial
Interventions: BIOLOGICAL: Certolizumab pegol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: School-based Approaches to Help Pre-teens Manage Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Open Airways Educational Intervention|BEHAVIORAL: Peer Asthma Action Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Status: RECRUITING
Conditions: Lung Cancer|Lung Cancer Metastatic|Brain Metastases|Brain Metastases, Adult|Small-cell Lung Cancer|Small Cell Lung Carcinoma
Interventions: RADIATION: Stereotactic Radiosurgery|PROCEDURE: Cerebrospinal fluid collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Phase II Trial With Intradermal IMO-2125 in Pathological Tumor Stage (p) T3-4 cN0M0 Melanoma
Status: RECRUITING
Conditions: Malignant Melanoma
Interventions: DRUG: Tilsotolimod|DRUG: Saline (0.9% sodium chloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Amlodipine in Hypertensive Non Responders Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: aliskiren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Cognitive and Neurobehavioral Functions After Repetitive Traumatic Brain Injuries (rTBI) in Retired NFL Players and Military Veterans.
Status: UNKNOWN
Conditions: Traumatic Brain Injury|Concussion|Mild Cognitive Disorder
Interventions: BEHAVIORAL: Psycho-Social Therapy|DEVICE: Cognitive Behavioral Computer Training|BEHAVIORAL: Interactive Trainer-Subject Sessions|DEVICE: Active Control Games
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AHN-12 Biodistribution in Advanced Leukemia
Status: TERMINATED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia
Interventions: BIOLOGICAL: 90Y-AHN-12
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Angiography for Peripheral Arterial Disease (PAD)
Status: UNKNOWN
Conditions: Peripheral Arterial Disease (PAD)
Interventions: DRUG: ferumoxytol|DRUG: ferumoxytol|DRUG: ferumoxytol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bridging Study of C11 Pittsburgh Compound B (PiB) and F18 Flutemetamol Brain Positron Emission Tomography (PET)
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: C11 PiB|DRUG: F18 Flutametamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Maxolon to Improve Breastmilk Supply in Diabetic Women: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Breastfeeding
Interventions: DRUG: Metoclopramide (Maxolon)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation of the Bacterially-Derived Healon5 Ophthalmic Viscosurgical Device (OVD)
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Investigational Healon5 OVD|DEVICE: Healon5 OVD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure
Status: RECRUITING
Conditions: Acute Hypoxemic Respiratory Failure|Acute Hypercapnic Respiratory Failure
Interventions: DEVICE: Experimental: Asymmetrical high-flow nasal cannula|DEVICE: Active comparator: Conventional high-flow nasal cannula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: First-line Cryoablation for Early Treatment of Persistent Atrial Fibrillation
Status: NOT_YET_RECRUITING
Conditions: Atrial Fibrillation, Persistent
Interventions: DEVICE: Pulmonary vein isolation|DRUG: dronedarone - Multaq™ OR flecainide - Tambocor™ OR propafenone - Rytmonorm™ OR sotalol - Sotacor™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Comparison of Femoral Nerve Versus Adductor Canal Block Following Anterior Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury
Interventions: DRUG: 30 ml of 0.2% ropivacaine|DRUG: 15 ml of 0.2% ropivacaine|DRUG: 100 mcg clonidine|DEVICE: High-frequency linear ultrasound transducer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Electroconvulsive Therapy and Concomitant Lithium in Depressive Disorder: A Pilot Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Depressive Disorder
Interventions: DRUG: Lithium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer|Pancreatic Cancer|Colorectal Cancer|Loss of Appetite|Fatigue|Cachexia
Interventions: DRUG: ponsegromab|DRUG: Placebo for ponsegromab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Efficacy in Patients With Malignant Rhabdoid Tumors (MRT) and Neuroblastoma
Status: TERMINATED
Conditions: Malignant Rhabdoid Tumors (MRT)|Neuroblastoma
Interventions: DRUG: LEE011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Web-Based Delivery of MOVE! to Veterans With Serious Mental Illness (SMI)
Status: COMPLETED
Conditions: Psychotic Disorders|Obesity|Health Behaviors
Interventions: BEHAVIORAL: in-person MOVE! SMI|BEHAVIORAL: web-based MOVE! SMI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ephedrine Versus Ondansetron During Cesarean Delivery
Status: COMPLETED
Conditions: Spinal Induced Hypotension
Interventions: DRUG: Ondansetron 4 MG|DRUG: Ondansetron 8mg|DRUG: EPHEDrine 10 Mg/mL-NaCl 0.9% Intravenous Solution|OTHER: 10 mL normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Musculotendinous Tissue Repair Unit and Reinforcement (MTURR)
Status: COMPLETED
Conditions: Traumatic Injury|Muscle Injury|Tendon Injury|Soft Tissue Injury|Extremity Injury
Interventions: DEVICE: Extracellular Matrix
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Envafolimab Combined With Endostar in the First-line Treatment of Advanced NSCLC
Status: RECRUITING
Conditions: Lung Neoplasms
Interventions: DRUG: Envafolimab|DRUG: Endostar
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Food Effect on the Pharmacokinetics of Sustained Release Metformin in Healthy Indian Volunteers
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin hydrochloride prolonged release|DRUG: metformin hydrochloride prolonged release|DRUG: Metformin hydrochloride sustained release/Glimepiride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy of IARULIL® in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract
Status: COMPLETED
Conditions: Recurrent Cystitis
Interventions: DRUG: hyaluronic acid and chondroitin sulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: COMISS Score for Detection of Cow's Milk Protein Allergy in Children With Recrrent or Persistent Gastrointestinal Manifistations in Infants Attending Assuit University Children Hospital - Egypt
Status: UNKNOWN
Conditions: Cow Milk Allergy
Interventions: DIAGNOSTIC_TEST: COMISS score
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: CLN-619|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Long-term Use of Alprazolam Extended Release (XL) in the Treatment of Adolescents With Panic Disorder
Status: TERMINATED
Conditions: Panic Disorder
Interventions: OTHER: placebo|DRUG: alprazolam XR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bumetanide in Hypokalaemic Periodic Paralysis
Status: TERMINATED
Conditions: Hypokalemic Periodic Paralysis
Interventions: DRUG: Bumetanide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peptic Ulcer Disease in Ischemic Heart Patients Taking Aspirin and Clopidogrel With or Without Proton Pump Inhibitor
Status: UNKNOWN
Conditions: Peptic Ulcer|Ulcer Complications
Interventions: DRUG: lansoprazole|DRUG: aluminum hydroxide 334 mg and Mg hydroxide 166 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Dietary Intervention on LDL-C and Lipoprotein Subclasses Distribution in Patients With Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia|Disease|Dyslipidemias
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Dietary portfolio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Offering a Self-sampling Device by the GP to Reach Underscreened Women
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: OTHER: Provision of self sampling device by the GP|OTHER: Provision of self sampling device by letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Occipital Nerve Stimulation in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Occipital nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simethicone: Does it Improve Operative Field and Postoperative Pain?
Status: COMPLETED
Conditions: Simethicone
Interventions: DRUG: Simethicone Tab 40 mg|DRUG: Placebo Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Safety and Pharmacokinetic Study of JHL1922 and Pulmozyme® in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: JHL1922|BIOLOGICAL: dornase alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Robotic Versus Laparoscopic Low Anterior Resection for Rectal Cancer
Status: UNKNOWN
Conditions: Rectal Neoplasms|Sexual Dysfunction|Urinary Incontinence|Quality of Life
Interventions: PROCEDURE: Robotic|PROCEDURE: Laparoscopic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of LEE011 in Combination With Buparlisib and Letrozole in HR+, HER2-negative Post-menopausal Women With Advanced Breast Cancer.
Status: COMPLETED
Conditions: Advanced or Metastatic Breast Cancer
Interventions: DRUG: LEE011|DRUG: Buparlisib|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: NATURE 3.2_New Approach for the Reduction of REnal Uremic Toxins
Status: COMPLETED
Conditions: Hemodialysis
Interventions: DIETARY_SUPPLEMENT: Symbiotic|DIETARY_SUPPLEMENT: Placebo|DEVICE: DVB cartridge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Efficacy of Erbium:YAG Laser in Postpartum Patients With Episiotomy Scars
Status: RECRUITING
Conditions: Episiotomy Wound|Laser|Vulvodynia|Vulva Pain
Interventions: DEVICE: Fotona Dynamis Er:YAG Laser System|DEVICE: Fotona Dynamis Er:YAG Laser System with Sham handpiece
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: ED Recovery in Men Age </=65 Treated With Bilateral Nerve Sparing Robotic Assisted Prostatectomy for Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer|Male Erectile Disorder|Stage I Prostate Cancer|Stage II Prostate Cancer
Interventions: DRUG: sildenafil citrate|DRUG: alprostadil|PROCEDURE: robotic-assisted laparoscopic surgery|PROCEDURE: quality-of-life assessment|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Status: RECRUITING
Conditions: Cluster Headache
Interventions: DRUG: Botulinum toxin type A|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tunneled Pleural Catheter in Partially Entrapped Lung
Status: COMPLETED
Conditions: Malignant Pleural Effusion
Interventions: PROCEDURE: VATS, Talc-Pleurodesis, tunneled pleural drainage|PROCEDURE: VATS, Talc-pleurodesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised Double-Blind Trial of Targeted Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DEVICE: Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: ECT
Clinical trial: Three Generic Nevirapine-Based Antiretroviral Treatments in Chinese Patients:Multicentric Observation Cohort
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine (AZT)+ Didanosine (ddI)+ Nevirapine (NVP)|DRUG: Stavudine (d4T), Lamivudine (3TC), Nevirapine (NVP)|DRUG: Zidovudine (AZT), Lamivudine (3TC), Nevirapine (NVP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Correlation of the Hand Grip Force With Maximum Inspiratory and Maximum Expiratory Pressure, in Critical Ill Patients
Status: COMPLETED
Conditions: Intensive Care Unit Syndrome
Interventions: DIAGNOSTIC_TEST: Hand Grip Force|DIAGNOSTIC_TEST: Maximal Inspiratory Pressure|DIAGNOSTIC_TEST: Maximal Expiratory Pressure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessing the Pharmacokinetics, Safety, Tolerability and Efficacy of Continuous Oral Levodopa Via the DopaFuse® Delivery System in Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: COMBINATION_PRODUCT: continuous oral delivery of levodopa/carbidopa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Light-Emitting Diode on the Strenght and Resistence Capacities of Cycling Athletes
Status: COMPLETED
Conditions: Athletes
Interventions: DEVICE: Light-Emitting Diode Device|DEVICE: Sham Light-Emitting Diode Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Double-blind Randomized Placebo-controlled Study Comparing Epanova and Fenofibrate on Liver Fat in Overweight Subjects.
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease (NAFLD|Hypertriglyceridemia
Interventions: DRUG: Placebo|DRUG: Omega-3 carboxylic acid|DRUG: Fenofibrate 200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bisphosphonate Coated Pins for Extern Fixation in Tibia Osteotomy
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Biphosfonate|DEVICE: Hydroxylapatit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG)
Status: TERMINATED
Conditions: Penile Squamous Cell Carcinoma Stage IV
Interventions: DRUG: Pazopanib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MR, Histologic And EM Imaging Of Intravenous Ferumoxytol In Central Nervous System (CNS) Inflammation
Status: TERMINATED
Conditions: Nervous System Diseases|Diagnostic Imaging
Interventions: DRUG: Ferumoxytol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: COVID-19 MP Biomedicals SARS-CoV-2 Ag OTC: Clinical Evaluation
Status: COMPLETED
Conditions: SARS-CoV2 Infection|COVID-19
Interventions: DEVICE: iCura COVID-19 Antigen Rapid Home Test|DEVICE: RT-PCR Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pembrolizumab and Epacadostat in Patients With Thymic Carcinoma
Status: UNKNOWN
Conditions: Thymic Carcinoma|Thymus Neoplasms|Thymus Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Epacadostat
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-2)
Status: COMPLETED
Conditions: Cataract
Interventions: DRUG: Clobetasol Propionate|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine
Status: UNKNOWN
Conditions: The Effect of S-ketamine on Pharmacokinetics of Morphine, Hydromorphone, and Buprenorphine
Interventions: DRUG: S-ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study Comparing Pad-gauze With Anti-fibrinolytic Agent Hemostopan™) to a Regular Pad-gauze
Status: UNKNOWN
Conditions: Bleeding|Coagulopathy
Interventions: DEVICE: pad-gauze with tranexamic acid (Hemostopan™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Meal Timing on Glucose and Hyperandrogenism in PCOS Women
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome (PCOS) Women
Interventions: BEHAVIORAL: Placebo Comparator: Lifestyle counseling Dinner Diet ARM 2|OTHER: Active Comparator: Lifestyle counseling ARM 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of Time-Restricted Feeding (TRF) in Acute Ischemic Stroke Patients
Status: UNKNOWN
Conditions: Fasting
Interventions: BEHAVIORAL: Time-restricted feeding (TRF) with dietary counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT