pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Study of Anti-CD56-CAR-T in the Treatment of Relapsed/Refractory NK/T Cell Lymphoma /NK Cell Leukemia
Status: RECRUITING
Conditions: Extranodal NK T Cell Lymphoma|NK-Cell Leukemia
Interventions: BIOLOGICAL: Anti-CD56 CAR T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Descriptive Study of the Angiogenic T Cell Population in Subjects With Hereditary Hemorrhagic Telangiectasia (HHT)
Status: COMPLETED
Conditions: Hereditary Hemorrhagic Telangiectasia
Interventions: BIOLOGICAL: Blood samples|OTHER: Epistaxis charts
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: BIOLOGICAL: autologous mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Nutritional Supplementation on Aerobic Performance and Fatigue
Status: COMPLETED
Conditions: Performance|Fatigue
Interventions: DRUG: NutraStem Active|DRUG: NutraStem Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PR104 in Treating Patients With Refractory/Relapsed Acute Leukemia
Status: UNKNOWN
Conditions: Acute Myelogenous Leukemia|Acute Lymphocytic Leukemia
Interventions: DRUG: PR104
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pan Immune Inflammation Value for Perioperative Complications of Laparoscopic Sleeve Gastrectomy
Status: COMPLETED
Conditions: Morbid Obesity|Laparoscopic Sleeve Gastrectomy|Post Operative Complicaiton
Interventions: PROCEDURE: Laparoscopic Sleeve Gastrectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM)
Status: TERMINATED
Conditions: Fetal Membranes, Premature Rupture
Interventions: PROCEDURE: Retention of Cerclage|PROCEDURE: Removal of Cerclage|PROCEDURE: Removal vs. Retention of Cervical Cerclage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Ambrisentan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AAT-APP+: A Novel Brain-training App to Reduce Drinking
Status: UNKNOWN
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: AAT-APP: A novel smart-phone approach-avoidance bias modification intervention|BEHAVIORAL: Sham training control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Obeticholic Acid (OCA) and Statins for Monitoring of Lipids (CONTROL)
Status: COMPLETED
Conditions: Nonalcoholic Steatohepatitis
Interventions: DRUG: Obeticholic Acid|DRUG: Atorvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin in Pulmonary Arterial Hypertension
Status: RECRUITING
Conditions: Pulmonary Arterial Hypertension|Chronic Thromboembolic Pulmonary Hypertension
Interventions: DRUG: Dapagliflozin 10 MG [Farxiga]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Methods of Tranexamic Acid Application in Controlling Peri Operative Bleeding in Gynecomastia Surgery
Status: NOT_YET_RECRUITING
Conditions: Pharmacological-Aggravated Urticaria
Interventions: DRUG: Tranexamic acid injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of High-dose Intravenous Selenium (Selenase®) in Adult Patients Subjected to Elective All-cause Heart Surgery
Status: COMPLETED
Conditions: Heart; Surgery, Heart, Functional Disturbance as Result|Self Efficacy
Interventions: DRUG: Selenase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Oligofructose and Barley on Satiety and Energy Intake
Status: COMPLETED
Conditions: Appetite Regulation
Interventions: DIETARY_SUPPLEMENT: beta-glucan and fructooligosaccharide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: FT825|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Bendamustine|DRUG: Docetaxel|DRUG: Cisplatin|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coronary and Structural Interventions Ulm - Bioresorbable Vascular Scaffold
Status: COMPLETED
Conditions: Coronary Artery Disease|Ischemic Heart Disease|Stable Angina|Unstable Angina|Acute Myocardial Infarction
Interventions: DEVICE: use of bioresorbable vascular scaffolds
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zonisamide vs. Placebo in the Treatment of Alcohol Dependence
Status: COMPLETED
Conditions: Alcoholism|Alcohol Abuse|Alcohol Dependence
Interventions: DRUG: zonisamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label, Safety and Efficacy Study of QRX003 Lotion in Subjects With Netherton Syndrome
Status: RECRUITING
Conditions: Netherton Syndrome
Interventions: DRUG: QRX003, 4% Lotion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVIG Treatment in Systemic Sclerosis
Status: UNKNOWN
Conditions: Systemic Sclerosis|Diffuse Scleroderma
Interventions: BIOLOGICAL: Privigen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Sunitinib Therapy in Renal Cell Carcinoma Using F-18 FDG PET/CT and DCE MRI
Status: COMPLETED
Conditions: Kidney Neoplasms|Carcinoma, Renal Cell|Kidney (Renal Cell) Cancer
Interventions: PROCEDURE: FDG PET CT|PROCEDURE: DCE MRI|DRUG: F-18 Fluoro-deoxi-glucose|DRUG: Gadolinium-DTPA|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Total Body PET-CT Imaging of Prostate Cancer Using Illuccix
Status: RECRUITING
Conditions: Metastatic Castration-resistant Prostate Cancer
Interventions: DRUG: illuccix 68Ga-PSMA-11 Total Body PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cytokine-induced Killer Study for Patients With Stage II Melanoma
Status: NOT_YET_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Cytokine-induced killer cells|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation and Cross-Cultural Adaptation of the Romanian Version of Oral Health Impact Profile in Edentulous Adults
Status: COMPLETED
Conditions: Severe Atrophy of the Edentulous Mandible
Interventions: PROCEDURE: Insertion of two screw type dental implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Covid-19 Messaging to Underserved Communities - 2nd Experiment
Status: COMPLETED
Conditions: Covid19
Interventions: BEHAVIORAL: Acknowledgement Racial Injustice AMA|BEHAVIORAL: African American Sender Acknowledgement|BEHAVIORAL: African American Sender in Informational Videos.|BEHAVIORAL: Racial Inequality Highlighted|BEHAVIORAL: AMA Acknowledgement Drug Pricing|BEHAVIORAL: White Sender in Acknowledgement|BEHAVIORAL: White Sender in Informational Videos|BEHAVIORAL: No Racial Inequality Highlighting|BEHAVIORAL: Placebo videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Monitoring in Dialysis -- a Prospective, Multi-center, Single-arm, Non-randomized, Observational Study in Patients Who Are Undergoing Hemodialysis.
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DEVICE: REVEAL Insertable Cardiac Monitor (ICM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Avelumab In Combination With Axitinib in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumor After Failure of Standard Therapy
Status: UNKNOWN
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Axitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modeling Spinal Mobility in Ankylosing Spondylitis: Towards New Telekinetic Biomarkers
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: DEVICE: XSENS-Awinda
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Observation and MRI Influence of Acupuncture on Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Arthritis Osteoarthritis
Interventions: OTHER: acupuncture|OTHER: physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Behavioral Economics to Reduce Low-Value Care
Status: ENROLLING_BY_INVITATION
Conditions: Pre-Operative Testing for Cataract Surgery
Interventions: BEHAVIORAL: Nudge #1: Alert highlighting the safety/potential harms to patients of undergoing pre-op tests|BEHAVIORAL: Nudge #2: Alert highlighting the financial harms to the patient experiencing pre-op tests|BEHAVIORAL: Nudge #3: Alert highlighting potential psychological harms to the patient of experiencing pre-op tests|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Peanuts on Immunity and Cardiometabolic Risk Factors
Status: NOT_YET_RECRUITING
Conditions: Immune Response|Cardiometabolic Risk Factors
Interventions: OTHER: Peanut intake
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: azithromycin|DRUG: placebo|DRUG: Tobramycin solution for inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA)
Status: COMPLETED
Conditions: Spinal Muscular Atrophy
Interventions: DRUG: nusinersen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Immunotherapy vs Standard Chemotherapy for Gastric Cancer With High Risk for Recurrence
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric and Esophagogastric Junction Adenocarcinoma
Interventions: DRUG: Nivolumab and Ipilimumab|OTHER: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Structured Early Palliative Care Intervention for Patients With Advanced Cancer - a Randomized Controlled Trial With a Nested Qualitative Study (SENS Trial)
Status: UNKNOWN
Conditions: Advanced Cancer
Interventions: BEHAVIORAL: SENS model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Probiotic Bacteria on the Efficacy of Anti-retroviral Therapy and Recurrence of Bacterial Vaginosis
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DIETARY_SUPPLEMENT: Yogurt supplemented with L. rhamnosus fiti|DIETARY_SUPPLEMENT: Yogurt not supplemented with a probiotic strain.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Compare Intraperitoneal Instillation of Bupivacaine+Dexmedetomidine Versus Bupivacaine+Dexamethasone on Postoperative Pain After Lap Cholecystectomy
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: bupivacaine with dexamethasone|DRUG: bupivacaine with dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the IBAIP in Preterm Infants Neurodevelopment
Status: RECRUITING
Conditions: Premature Birth
Interventions: OTHER: IBAIP : Infant Behaviour Assessment and Intervention Program|OTHER: Standard Support|OTHER: Ages and Stages Questionnaire (ASQ)|OTHER: Parenting Stress Index (PSI)|OTHER: Bayley Scales of Infant and Toddler Development (BSID-III)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft
Status: RECRUITING
Conditions: Allogeneic Hematopoietic Cell Transplantation (HCT)|Advanced Hematologic Malignancies|Acute Leukemia|Chronic Myelogenous Leukemia|Myelodysplastic Syndromes|Myeloproliferative Disorders
Interventions: DRUG: Purified regulatory T-cells (Treg) plus CD34+ HSPC|DRUG: Fludarabine|DRUG: Melphalan|DEVICE: CliniMACS CD34 Reagent System|DRUG: Tacrolimus|DRUG: Cyclophosphamide|DRUG: Plerixafor|DRUG: Filgrastim granulocyte colony-stimulating factor (G-CSF) or equivalent|DRUG: Thiotepa|DRUG: Mycophenolate Mofetil (MMF)|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.
Status: UNKNOWN
Conditions: Romano-Ward Syndrome|Long QT Syndrome|Compulsive Behavior|Healthy Individuals
Interventions: BEHAVIORAL: Cognitive assessment of obsessive-compulsive and impulsive behaviours|GENETIC: Genomic analysis|DIAGNOSTIC_TEST: Glucoregulation assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gut Microbiota in Intestinal Barrier Damage in Acute Leukemia Patients Undergoing Inpatient Induction
Status: COMPLETED
Conditions: Chemotherapy-Induced Gut Barrier Damage|Acute Leukemia
Interventions: DIAGNOSTIC_TEST: Observational: Stool Sample Collection|DIAGNOSTIC_TEST: Observational: Blood Sample Collection|DIAGNOSTIC_TEST: Observational: Urine Sample Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multiple Dose Safety Toelrability, Pharmacokinetics and Midazolam Interaction In Healthy Overweight And Obese Subjects
Status: COMPLETED
Conditions: Diabetes Mellitus|Diabetes Mellitus, Type 2|Glucose Metabolism Disorders
Interventions: DRUG: Pf-05175157|DRUG: placebo|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sequential Use of Teriparatide and Raloxifene HCl in the Treatment of Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal
Interventions: DRUG: teriparatide|DRUG: raloxifene HCl|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction With a Single-dose Dexmedetomidine
Status: COMPLETED
Conditions: Igel
Interventions: DRUG: propofol concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: AcQForce Pulsed Field Ablation-CE
Status: COMPLETED
Conditions: Atrial Arrhythmia|Atrial Fibrillation
Interventions: DEVICE: Acutus Medical Pulsed Field Ablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Post-market Study to Evaluate Zip Device Compared to Sutures for Laceration Repair in Pediatrics and Adults
Status: COMPLETED
Conditions: Laceration
Interventions: DEVICE: Zip surgical skin closure device|DEVICE: Standard of Care sutures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of Azithromycin to Cefazolin Will Reduce Post CS Infections More Than Cefazolin Only.
Status: UNKNOWN
Conditions: Randomized Controll Trial
Interventions: DRUG: Azithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Glycine Powder Air-Polishing Combined With Scaling and Root Planing in the Treatment of Periodontitis and Halitosis
Status: COMPLETED
Conditions: Halitosis
Interventions: DEVICE: glycine powder air-polishing (Air-Flows)Perio Powder|DEVICE: ultrasonic (Piezon Master 700; EMS, Nyon, Switzerland)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: tDCS in Acute Stroke Patients
Status: UNKNOWN
Conditions: Acute Stroke
Interventions: DEVICE: tDCS neuroConn|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing Weight Bias Internalization to Improve Adolescent Weight Management Outcomes
Status: RECRUITING
Conditions: Body Weight|Weight Bias|Weight Stigma|Weight
Interventions: BEHAVIORAL: Behavioral Weight Management|BEHAVIORAL: Weight Bias Internalization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
Status: NOT_YET_RECRUITING
Conditions: Interstitial Lung Disease|Acute Respiratory Failure
Interventions: DEVICE: Noninvasive mechanical ventilation|DEVICE: Nasal high-flow oxygen therapy|DEVICE: Continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cold Magnesium Sulfate Solution for Perineal Swelling Following Vaginal Delivery
Status: UNKNOWN
Conditions: Vaginal Delivery|Perineal Swelling|Perineal Pain
Interventions: OTHER: Cold pads soaked in Magnesium sulfate solution|OTHER: Cold pads soaked in water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Protective Effects of Sevoflurane in Pediatric Cardiac Surgery
Status: UNKNOWN
Conditions: Congenital Heart Diseases
Interventions: DRUG: Sevoflurane|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Nasal Naloxone and Injected Naloxone Compared
Status: COMPLETED
Conditions: Drug Overdose
Interventions: DRUG: Intranasal (IN) naloxone 1x|DRUG: Intranasal (IN) naloxone 2|DRUG: Intravenous (IV) naloxone|DRUG: Intramuscular (IM) naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Study of Combined Immune Cell Therapy in Patients With Stage 4 Colorectal Cancer With Metastatic Lesion Who Failed Prior Standard of Care
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer Stage IV|Metastatic Colorectal Cancer
Interventions: BIOLOGICAL: Combi
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: 150 mg of Nestorone and 15 mg of ethinyl estradiol (150/15 NES/EE CVR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut Syndrome
Status: COMPLETED
Conditions: Epilepsy|Seizures
Interventions: DRUG: topiramate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Montelukast Asthmatic Smoker Study (0476-332)(COMPLETED)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: montelukast sodium|DRUG: Comparator: Placebo|DRUG: Comparator: fluticasone|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CSD170304: Study to Assess Nicotine Uptake in Smokers From Electronic and Combustible Cigarettes
Status: COMPLETED
Conditions: Smoking
Interventions: OTHER: FT210771|OTHER: FT210751|OTHER: 6T30134157764|OTHER: G41A7C071|OTHER: M011161212|OTHER: FT21002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Nivolumab or Nivolumab Plus Experimental Medication BMS-986205 With or Without Bacillus Calumette-Guerin (BCG) in BCG Unresponsive Bladder Cancer That Has Not Invaded Into the Muscle Wall of the Bladder
Status: TERMINATED
Conditions: Urinary Bladder Neoplasms
Interventions: BIOLOGICAL: Nivolumab|BIOLOGICAL: BCG|DRUG: BMS-986205
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Presenting Summary Information From Cochrane Systematic Reviews
Status: COMPLETED
Conditions: Understanding Cochrane Systematic Reviews
Interventions: OTHER: Infographic presentation of health information|OTHER: PLS presentation of health information|OTHER: Scientific abstract presentation of health information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Personalized Prevention Program (PPP) Based on the Comprehensive Geriatric Assessment (CGA) for the Prevention of Multidimensional Frailty Related to Non-communicable Chronic Diseases (NCDs) in Older People
Status: RECRUITING
Conditions: Older People|Non-Communicable Chronic Diseases
Interventions: COMBINATION_PRODUCT: Brief-MPI assessment (based on the Comprehensive Geriatric Assessment); Personalized Prevention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986256 in Healthy Male Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986256|DRUG: Milk of magnesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock
Status: UNKNOWN
Conditions: Shock|Septic Shock
Interventions: DIAGNOSTIC_TEST: Left ventricular diastolic function|DIAGNOSTIC_TEST: Inferior vena cava variation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Rotational Thromboelastography Study in Tranexamic Acid and Colloid Infusion
Status: COMPLETED
Conditions: Avascular Necrosis of Femoral Head|Degenerative Arthritis of Hip
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Study of Aripiprazole in the Treatment of Methamphetamine Dependence
Status: TERMINATED
Conditions: Methamphetamine Dependence
Interventions: DRUG: Aripiprazole|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Corneal Crosslinking Treatment Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Progressive Keratoconus
Interventions: PROCEDURE: Corneal crosslinking: CXL (UVA 9mW/cm2)|DRUG: Isotonic riboflavin|DRUG: Hypotonic riboflavin|PROCEDURE: Iontophoresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of the Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Mini Gastric Bypass on the Remission of Type II Diabetes Mellitus
Status: UNKNOWN
Conditions: Obesity, Morbid|Type 2 Diabetes Mellitus
Interventions: PROCEDURE: laparoscopic Roux-en-Y gastric bypass|PROCEDURE: laparoscopic Mini gastric bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Regimens for Medical Abortion: Mifepristone + Misoprostol Versus Misoprostol Alone
Status: COMPLETED
Conditions: Complete Abortion
Interventions: DRUG: medical abortion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Dexamethasone Before Spinal Anesthesia on Post-cesarean Section Pain
Status: UNKNOWN
Conditions: Cesarean Section
Interventions: DRUG: Dexamethasone|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Graft-Versus-Host Disease Prevention in Treating Patients Who Are Undergoing Bone Marrow Transplantation
Status: COMPLETED
Conditions: Graft Versus Host Disease|Leukemia|Lymphoma
Interventions: DRUG: cyclosporine|DRUG: methotrexate|PROCEDURE: allogeneic bone marrow transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficiency of Autologous Amniotic Fluid Injection in the Healing of Cesarean Section Scar in High-Risk Population
Status: COMPLETED
Conditions: High Risk Pregnancy|Healing Surgical Wounds
Interventions: BIOLOGICAL: autologous amniotic fluid|OTHER: No amniotic fluid injected in skin edges
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Endobronchial Valve for Emphysema PalliatioN Trial (VENT) Cost-effectiveness Sub-Study
Status: TERMINATED
Conditions: Emphysema|Chronic Obstructive Pulmonary Disease
Interventions: DEVICE: Emphasys Endobronchial Valve (EBV) Device and Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of New Human Models of Non-histaminergic Itch
Status: COMPLETED
Conditions: Papain|Itch|Skin Prick Test (SPT)
Interventions: DRUG: Papain 10 µg|DRUG: Papain 50 µg|DRUG: Papain 100 µg|OTHER: Vehicle|DRUG: Papain 1 SPT|DRUG: Papain 5 SPT|DRUG: Papain 25 SPT|OTHER: Cowhage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Balance Assessment Scale and Strength Measurement Protocol to Measure Functionality in Adults With Spinal Deformity
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Deformity
Interventions: DIAGNOSTIC_TEST: Balance Assessment Scale|DIAGNOSTIC_TEST: Trunk strength measurement with EMG|DIAGNOSTIC_TEST: MRI spine/pelvis|DIAGNOSTIC_TEST: EOS stereoradiographic full body exam|DIAGNOSTIC_TEST: Balance Assessment Scale 2|DIAGNOSTIC_TEST: Trunk strength measurement with EMG 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: TPO-RAs Combining Anti-CD 20 Monoclonal Antibody Versus TPO-RAs in the Management of Pediatric Primary Immune Thrombocytopenia (ITP)
Status: RECRUITING
Conditions: Primary Immune Thrombocytopenia (ITP)
Interventions: DRUG: TPO-RAs|DRUG: TPO-RAs combining anti-CD 20 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nandrolone Decanoate in the Treatment of Telomeropathies
Status: COMPLETED
Conditions: Aplastic Anemia|Bone Marrow Failure Syndromes|Idiopathic Pulmonary Fibrosis|Telomere Shortening
Interventions: DRUG: Nandrolone Decanoate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1b/2 Study Testing Radium-223 Dichloride/Bortezomib/Dexamethasone Combination in Relapsed Multiple Myeloma
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Radium-223 dichloride (Xofigo, BAY88-8223)|DRUG: Placebo|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4)
Status: TERMINATED
Conditions: Uterine Fibroids
Interventions: DRUG: Vilaprisan (BAY1002670)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Costovertebral Mobilization on Kyphotic Posture and Lung Function in Non-Smoker
Status: RECRUITING
Conditions: Hyperkypohsis and Impaired Lung Function
Interventions: OTHER: Costovertebral Mobilization+Conventional Therapy|OTHER: Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms
Status: RECRUITING
Conditions: T-Cell Neoplasm|Lymphoproliferative Disorders
Interventions: DRUG: Pacritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Propionyl-L-Carnitine Hydrochloride in Patients With Mild Ulcerative Colitis; Efficacy, Safety and Tolerability Study
Status: TERMINATED
Conditions: Ulcerative Colitis
Interventions: DRUG: Propionyl-L-Carnitine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Apple Derived Flavanols on Cardiovascular Disease Risk (FLAVASCULAR Study)
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Low Epicatechin and procyanidin|DIETARY_SUPPLEMENT: High Epicatechin and procyanidin|DIETARY_SUPPLEMENT: High procyanidin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Complexity and Frailty in Cardiothoracic and Vascular Anesthesia (CAfCA). Prospective Multicentric Observational Study
Status: RECRUITING
Conditions: Frailty|Anesthesia|Thoracic Surgery|Cardiothoracic Surgery|Vascular Surgery|Comorbidities and Coexisting Conditions
Interventions: OTHER: Data collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder
Status: RECRUITING
Conditions: Schizophrenia|Bipolar I Disorder|Autism Spectrum Disorder (ASD)
Interventions: DRUG: Cariprazine Flexible Dose|DRUG: Cariprazine Flexible Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Belinostat in Treating Patients With Advanced Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer or Ovarian Low Malignant Potential Tumors
Status: COMPLETED
Conditions: Fallopian Tube Carcinoma|Primary Peritoneal Carcinoma|Recurrent Borderline Ovarian Surface Epithelial-Stromal Tumor|Recurrent Ovarian Carcinoma|Stage III Borderline Ovarian Surface Epithelial-Stromal Tumor|Stage III Ovarian Cancer|Stage IV Borderline Ovarian Surface Epithelial-Stromal Tumor|Stage IV Ovarian Cancer
Interventions: DRUG: Belinostat|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repair by Rehabilitation of Pelvic Floor Lesions After Vaginal Delivery Identified by Transperineal Ultrasound 3/4 D
Status: COMPLETED
Conditions: Pelvic Floor Disorders|Obstetric Trauma|Physical Disorder|Physical Activity
Interventions: OTHER: Physiotherapy treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction
Status: RECRUITING
Conditions: Neurogenic Dysfunction of the Urinary Bladder|Multiple Sclerosis|Sacral Neuromodulation|Bowel Dysfunction|Sexual Dysfunction|Quality of Life
Interventions: DEVICE: Turning ON the neuromodulator|DEVICE: Turning OFF the neuromodulator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Count Coughs in Subjects With Acute Upper Respiratory Tract Infections
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: Placebo|DRUG: Guaifenesin|OTHER: Buckwheat Honey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dideoxycytidine ( Ro 24-2027 ). A Treatment Protocol for the Use of Dideoxycytidine ( ddC ) in Patients With AIDS or Advanced ARC Who Cannot Be Maintained on Zidovudine ( AZT ) Therapy.
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid in Adherent Placenta (TAP)
Status: WITHDRAWN
Conditions: Placenta Accreta
Interventions: DRUG: Tranexamic Acid (TXA)|DRUG: Sodium Chloride 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Enhancing the Effectiveness of Cognitive Behavioral Therapy Using Non-invasive Brain Stimulation
Status: RECRUITING
Conditions: Depression|Anxiety|Stress Disorders, Post-Traumatic
Interventions: DEVICE: MxN-9 HD-tES Stimulator (Soterix Inc.)|DEVICE: Sham Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical Impact of Isolation of Two Different Bacteria in Urinary Cultures
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: OTHER: reporting of two different bacteria in urine culture|OTHER: reporting "mixed growth" on urine culture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Is Multifactorial Nutritional Treatment for Undernutrition in Older Adults in Primary Care Cost-effective?
Status: COMPLETED
Conditions: Frail Older Adults
Interventions: OTHER: multifactorial nutritional intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis
Status: RECRUITING
Conditions: Myelofibrosis|High-Risk Cancer|Bone Marrow Cancer
Interventions: BIOLOGICAL: Hematopoietic stem cell transplant|DRUG: Ruxolitinib|DRUG: Hydroxyurea
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prophylactic Treatment of Travellers' Diarrhoea With Rifaximin
Status: COMPLETED
Conditions: Diarrhoea
Interventions: DRUG: Rifaximin|DRUG: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy
Status: UNKNOWN
Conditions: Telomere Shortening|Telomere Length, Mean Leukocyte
Interventions: DRUG: Danazol 200 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesorectal Microbiome as a Prognostic Factor in Patients With Rectal Cancer
Status: RECRUITING
Conditions: Rectal Cancer
Interventions: PROCEDURE: Stool sample|PROCEDURE: Rectal mucosa sample|PROCEDURE: Mesorectal adipose tissue sample|PROCEDURE: Subcutaneous adipose tissue sample|PROCEDURE: Visceral adipose tissue sample|BEHAVIORAL: Dietary assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: To Study the Pathophysiological Features of Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis|Neurofilament Light Chain|Glial Fibrillary Acidic Protein
Interventions: DRUG: 18F-PM-PBB3
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Letrozole Pretreatment With Misoprostol for Second-Trimester Medical Abortion
Status: COMPLETED
Conditions: Miscarriage
Interventions: DRUG: Letrozole|DRUG: Placebo|DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of EGP-437 (Dexamethasone Phosphate Formulated for Ocular Iontophoresis) to Treat Dry Eye
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Dexamethasone phosphate ophthalmic solution|DRUG: Sodium citrate buffer solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Information About HIV Transmission and Circumcision on Subsequent Sexual Behavior, and the Demand for Circumcision
Status: COMPLETED
Conditions: Sexual Behavior|Dis-inhibition
Interventions: OTHER: Information|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of L-Pantoprazole Sodium Injection to Treat Upper Gastrointestinal Ulcer Bleeding
Status: UNKNOWN
Conditions: Bleeding Gastric Ulcer|Bleeding Duodenal Ulcer
Interventions: DRUG: L-pantoprazole sodium|DRUG: Panmeilu
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without High Dose Cyclophosphamide and Recombinant Interferon Alfa-2b in Treating Patients With Previously Untreated Stage I-III Multiple Myeloma
Status: COMPLETED
Conditions: Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma
Interventions: DRUG: vincristine sulfate|DRUG: carmustine|DRUG: melphalan|DRUG: cyclophosphamide|DRUG: prednisone|BIOLOGICAL: recombinant interferon alfa-2b|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hypovitaminosis D and "Metabolic" Inflammatory Status in Patients With Obesity
Status: COMPLETED
Conditions: Hypovitaminosis D|Obesity
Interventions: DIAGNOSTIC_TEST: Vitamin D Plasma Level|DIAGNOSTIC_TEST: Bioelectrical Impedance Analysis (BIA) technique|DIAGNOSTIC_TEST: Ferritin|DIAGNOSTIC_TEST: C reactive protein (CRP)|DIAGNOSTIC_TEST: Inflammation-based prognostic scores|OTHER: Liver biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: tDCS Effects on Brain Plasticity in Aphasia Treatment
Status: RECRUITING
Conditions: Aphasia|Stroke
Interventions: DEVICE: Real tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Hepatitis C Virus (HCV) Nonstructural Protein 5a (NS5A) Inhibitor IDX719 in Healthy and HCV-Infected Participants (MK-1894-001)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: IDX719|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Combined Temozolomide and SGT-53 for Treatment of Recurrent Glioblastoma
Status: TERMINATED
Conditions: RECURRENT GLIOBLASTOMA
Interventions: GENETIC: SGT-53|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Simvastatin and Metformin in Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: Placebo gel|DRUG: 1% Metformin|DRUG: 1.2% Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Force Feedback With the SoftHand Pro
Status: COMPLETED
Conditions: Amputation, Traumatic|Limb Defect
Interventions: DEVICE: SoftHand Pro with CUFF force feedback device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy
Status: ENROLLING_BY_INVITATION
Conditions: Lower Back Pain|Lumbosacral Radiculopathy
Interventions: DRUG: Qutenza® 8% Capsaicin Topical System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant Therapy Study Guided by Drug Screening in Vitro for Human Epidermal Growth Factor Receptor 2 (HER2) Negative Early Breast Cancer Patients
Status: RECRUITING
Conditions: HER2-negative Early Breast Cancer
Interventions: DRUG: neoadjuvant chemotherapy upon in vitro PTC drug sensitivity screening for triple negative breast cancer|DRUG: neoadjuvant chemotherapy upon in vitro PTC drug sensitivity screening for luminal like breast cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supportive Measures in Treatment of Aluminum Phosphide Poisoning
Status: COMPLETED
Conditions: Detection of Different Prognostic Factors and Their Relation With the Outcome|Using New Protocol to Prove the Role of N-acetyl Cysteine and Adequate Supportive Measures in Aluminum Phosphide Poisoning
Interventions: DRUG: N-acetyl cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study Comparing Restylane® Silk and Belotero Balance® for the Treatment of Superficial, Vertical Perioral Lines
Status: UNKNOWN
Conditions: Perioral Rhytids
Interventions: DRUG: Restalyne Silk|DRUG: Belotero Balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulating Socially Adaptive Mirror System Functioning in Autism by Oxytocin
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Oxytocin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE