pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Ridge Augmentation With Simultaneous Implant Placement Using Bone Blocks With Autogenous Tooth Graft
Status: COMPLETED
Conditions: Ridge Augmentation|Implant|Autogenous Tooth Graft
Interventions: PROCEDURE: ABB and ATG with simultaneous implant placement|PROCEDURE: XBB and ATG with simultaneous implant placement|PROCEDURE: ABB and ABG with simultaneous implant placement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-Finding, Efficacy and Safety Study of YY-351 in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes
Interventions: DRUG: YY-351/Placebo|DRUG: YY-351/Placebo|DRUG: YY-351|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis
Status: UNKNOWN
Conditions: Renal Failure, End Stage|Peritoneal Dialysis
Interventions: DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: In Situ, Autologous Therapeutic Vaccination Against Solid Cancers With Intratumoral Hiltonol®
Status: COMPLETED
Conditions: Melanoma|Head and Neck Cancer|Sarcoma|Non-Melanoma Skin Cancers
Interventions: BIOLOGICAL: Hiltonol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: pancrelipase with bicarbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Multi-center, Placebo-controlled Study to Evaluate NT100 in Pregnant Women With a History of Unexplained Recurrent Pregnancy Loss (RPL)
Status: UNKNOWN
Conditions: Recurrent Pregnancy Loss|Recurrent Miscarriage
Interventions: DRUG: NT100|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Magnetic Resonance Imaging in Assessing Affect Reactivity and Regulation in Patients With Stage 0-III Breast Cancer
Status: COMPLETED
Conditions: Healthy Subject|Stage 0 Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Functional Magnetic Resonance Imaging|OTHER: Questionnaire Administration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Citrulline in Severe Sepsis
Status: COMPLETED
Conditions: Severe Sepsis|Acute Lung Injury
Interventions: DRUG: High Dose Citrulline|DRUG: Placebo|DRUG: Low Dose Citrulline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ropivacaine vs Lidocaine in the Endotracheal Tube Cuff on Post-Operative Sore Throat
Status: COMPLETED
Conditions: Pharyngitis|Lidocaine|Ropivacaine|Intubation, Intratracheal|Post-operative Sore Throat
Interventions: DRUG: Ropivacaine 0.5% Injectable Solution|DRUG: Lidocaine 2% Preservative-Free Injectable Solution|OTHER: Air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Limbal Relaxing Incisions Versus Paired 4 mm Clear Corneal Incisions on Steep Meridian During Phacoemulsification
Status: NOT_YET_RECRUITING
Conditions: Corneal Astigmatism
Interventions: PROCEDURE: surgical correction of astigmatism with cataract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study With TS-142 in Healthy Adult Subjects (Concomitant Administration of Itraconazole)
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: TS-142|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Different Physical Therapy Resources Application After Reduction Stomach Surgery
Status: COMPLETED
Conditions: Pulmonary Atelectasis|Respiratory Tract Diseases|Pathological Conditions, Signs and Symptoms
Interventions: PROCEDURE: Continuous positive airway pressure|PROCEDURE: Incentive spirometry|PROCEDURE: Breath Stacking|PROCEDURE: Expiratory Positive Airway Pressure|PROCEDURE: Intermittent positive pressure breathing|PROCEDURE: Bi-level positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple Negative Breast Cancer|Endometrial Cancer|Solid Tumor, Unspecified, Adult|Colorectal Cancer
Interventions: DRUG: Fruquintinib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Bacterial Loads of Essix Retainers in Patients Under Retention Therapy
Status: COMPLETED
Conditions: Orthodontic Appliance Complication
Interventions: OTHER: Retainers' Cleansing with Geldis®|OTHER: Retainers' Cleansing with tablets|OTHER: Retainers' cleansing with water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Distal Needling on Knee Pain Using Acupuncture Techniques
Status: COMPLETED
Conditions: Patellar Tendonitis|Complete Tear, Knee, Anterior Cruciate Ligament
Interventions: DEVICE: Pain relief by Acupuncture needle at non-specific site|DEVICE: Acupuncture needle|DEVICE: Acupuncture needle|DEVICE: Acupuncture needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biomarkers in Patients With Stage III or Stage IV Follicular Lymphoma Treated on Clinical Trial E-1496
Status: COMPLETED
Conditions: Lymphoma
Interventions: GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymorphism analysis|OTHER: diagnostic laboratory biomarker analysis|OTHER: immunohistochemistry staining method|OTHER: immunologic technique
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-contact Boxing Training and Traditional Therapeutic Exercise for Persons With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: BEHAVIORAL: Traditional Therapeutic Exercise|BEHAVIORAL: Non-Contact Boxing Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Immunogenicity and Safety of Panblok® (H7 rHA) in Healthy Adults Aged 18 and Older
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Panblok|BIOLOGICAL: rHA adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Post-authorization Study to Describe the Safety and Efficacy of Emapalumab for the Treatment of pHLH in Treatment Experienced Chinese Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Hemophagocytic Lymphohistiocytosis
Interventions: DRUG: Emapalumab-Lzsg 5 MG/ML [Gamifant]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medication Adherence Program
Status: RECRUITING
Conditions: Hypertension|Medication Adherence|Behavior and Behavior Mechanisms
Interventions: BEHAVIORAL: STAR-MAP health coaching|BEHAVIORAL: Medication reminder tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial
Status: COMPLETED
Conditions: Gastrointestinal Hemorrhage
Interventions: DRUG: Pantoprazole|DRUG: Placebo (for pantoprazole)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spironolactone Versus Spironolactone Plus Furosemide (SVSSF)
Status: COMPLETED
Conditions: Cirrhosis|Ascites
Interventions: DRUG: Spironolactone and furosemide|DRUG: Spironolactone and furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The National Program for the Improvement of Management of Fetal Congenital Heart Disease in China
Status: NOT_YET_RECRUITING
Conditions: Congenital Heart Disease in Pregnancy|Prenatal Diagnosis|Fetal Echocardiography
Interventions: COMBINATION_PRODUCT: Improvement on Prenatal Screening and Treatment Capabilities for Congenital Heart Disease with a Comprehensive Diagnosis and Treatment Program Incorporating New Technologies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Zevalin and BEAM High-dose Chemotherapy Compared With BEAM Alone as Conditioning Regimen in Patients With Chemosensitive Relapse of Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: 90Yttrium Ibritumomab Tiuxetan (Zevalin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Reactogenicity and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' RSV Investigational Vaccine (ChAd155-RSV) (GSK3389245A) in Healthy Adults
Status: COMPLETED
Conditions: Respiratory Synctial Virus Infections
Interventions: BIOLOGICAL: GSK3389245A_LD GROUP|BIOLOGICAL: GSK3389245A_HD GROUP|BIOLOGICAL: Bexsero|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tele-Nursıng Based On Roper-Logan-Tıerney Model On Self-Care Of Hypertensıon Patıents: A Randomızed Controlled Trıal
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of the Use of Various Assessments of Common Cold Symptoms for Proof of Efficacy of ColdZyme Mouth Spray
Status: COMPLETED
Conditions: Common Cold
Interventions: DEVICE: ColdZyme
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Novabupi® in Spinal Anesthesia in Lower Limbs Vascular Surgery
Status: UNKNOWN
Conditions: Spinal Anesthesia|Vascular Surgery
Interventions: DRUG: bupivacaine S75:R25 plus 8% glucose|DRUG: bupivacaine S50:R50 plus 8% glucose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Polidocanol Foam Versus Rubber Band Ligation in the Treatment of Hemorrhoidal Disease
Status: COMPLETED
Conditions: Hemorrhoids, Internal
Interventions: DRUG: Polidocanol Injectable Foam|DEVICE: Rubber band ligation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Preliminary Efficacy of HH-120 for the Treatment of COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: HH-120|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influencing Factors and Mechanism of High Incidence of Thrombotic Events in Patients With MN and DKD
Status: ACTIVE_NOT_RECRUITING
Conditions: Glomerulonephritis, Membranous|Diabetic Nephropathies|Thrombelastography|Thromboembolism
Interventions: OTHER: Grouping based on previous laboratory results, no intervention.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia Ph Positive
Interventions: DRUG: Imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial Hypercholesterolemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Familial Hypercholesterolemia - Homozygous
Interventions: DRUG: Inclisiran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TOD-IBD: Empowering Patients On-Demand
Status: NOT_YET_RECRUITING
Conditions: Inflammatory Bowel Diseases|Telemonitoring|Patient Empowerment|Self Efficacy
Interventions: OTHER: On-Demand Telemonitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Adjuvant Chemotherapy in Patients With Clinical Stage III Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy
Status: RECRUITING
Conditions: Rectal Neoplasms
Interventions: DRUG: Capecitabine|DRUG: mFOLFOX6 or CAPOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Metabolites of Meal Challenge Test in Diabetes State
Status: UNKNOWN
Conditions: Type2 Diabetes|Postprandial Hyperglycemia
Interventions: BEHAVIORAL: Strategies to lower postprandial hyperglycemia in T2D patients|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection?
Status: TERMINATED
Conditions: Covid19|SARS-CoV Infection
Interventions: DRUG: Losartan|DRUG: Valsartan|DRUG: Azilsartan|DRUG: Candesartan|DRUG: Eprosartan|DRUG: Irbesartan|DRUG: Olmesartan|DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug Utilization and Safety Events Among Children Using Esomeprazole, Other Proton Pump Inhibitors or H2-receptor Antagonists
Status: COMPLETED
Conditions: Hospitalized Cases of Angioneurotic Oedema|Pneumonia|Gastroenteritis|Failure to Thrive|Seizures|Acute Interstitial Nephritis and Thrombocytopenia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Two Different Sedation Regimes on Auditory Evoked Potentials and Electroencephalogram (EEG)
Status: COMPLETED
Conditions: Conscious Sedation|Deep Sedation|Critical Care
Interventions: DRUG: Dexmedetomidine|DRUG: Midazolam|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fast Food, Fatigue, and Inflammation
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Saturated Fat Meal|OTHER: Oleic Sunflower Oil Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microfragmented Adipose Tissue Injection Compared to Hyaluronic Acid for Treatment of Temporomandibular Joint Osteoarthritis
Status: NOT_YET_RECRUITING
Conditions: Temporomandibular Joint Osteoarthritis
Interventions: BIOLOGICAL: adipose tissue fragmented
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicomponent Intervention for Prevention and Treatment of Sleep Disturbances in a Psychiatric Intensive Care Unit
Status: UNKNOWN
Conditions: Dyssomnias
Interventions: BEHAVIORAL: Sueña component 1: Sleep Hygiene Promotion|BEHAVIORAL: Sueña component 2: Periodic Anxiety and Pain Screening|BEHAVIORAL: Sueña component 3: Hypnotics and Caffeine Regulation|BEHAVIORAL: Sueña component 4: Sleep Masks and Ear Plugs|OTHER: Sueña component 5: Personalized Psychoeducation|DEVICE: Sueña component 6: Sleep Reports
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact and Influence of the Use of Hypnosis Adapted to People With Severe Stage Neurocognitive Disorder (HAPNeSS) on the Professional Practices of EHPAD (Establishment for Dependent Elderly People) Caregivers With Elderly Residents
Status: NOT_YET_RECRUITING
Conditions: Alzheimer Disease|Behavior Disorders
Interventions: OTHER: professional caregiver
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: oblimersen sodium|DRUG: dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: iWalk Hands Free Crutch
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: BOOT|DEVICE: HFC|DEVICE: SAC|DEVICE: HFC+BOOT|DEVICE: SAC+BOOT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surface Refractive Index Shift and Lens Absorption/Adsorption of Tear Components of Kalifilcon A Lenses vs Dailies Total1 and Precision1
Status: COMPLETED
Conditions: Habitual Soft Contact Lens Use
Interventions: DEVICE: Kalifon A|DEVICE: Dailies Total1|DEVICE: Precision1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CUHK Brain Health Longitudinal Study
Status: RECRUITING
Conditions: Stroke, Ischemic|Stroke Syndrome|Stroke|Stroke, Acute|Dementia|Brain Ischemia|Brain Diseases|Alzheimer Disease|Health Attitude|Health Knowledge, Attitudes, Practice|Health Personnel Attitude|Healthy Aging
Interventions: BEHAVIORAL: Neuro-QoL questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients.
Status: COMPLETED
Conditions: Critical Illness
Interventions: DRUG: Omeprazole|DRUG: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Paroxetine and PAXIL Under Fasting Conditions in Healthy Mexican Participants
Status: COMPLETED
Conditions: Anxiety Disorders
Interventions: DRUG: Paroxetine hydrochloride|DRUG: PAXIL (Paroxetine hydrochloride )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isolation Procedure vs. Conventional Procedure During Distal Pancreatectosplenectomy for Pancreatic Cancer
Status: RECRUITING
Conditions: Resectable Pancreatic Body/Tail Carcinoma
Interventions: PROCEDURE: Isolation procedure (RAMPS procedure)|PROCEDURE: Conventional procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Romiplostim in Chemotherapy-Induced Thrombocytopenia
Status: RECRUITING
Conditions: Chemotherapy-induced Thrombocytopenia|Solid Malignancy
Interventions: DRUG: Romiplostim
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Escitalopram and Language Intervention for Subacute Aphasia
Status: RECRUITING
Conditions: Aphasia|Stroke
Interventions: DRUG: Escitalopram 10mg|DRUG: Placebo|BEHAVIORAL: Computer-delivered naming treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of WATCHMAN Left Atrial Appendage Occlusion Device in Patients With Atrial Fibrillation Versus Rivaroxaban
Status: UNKNOWN
Conditions: Atrial Fibrillation|Stroke
Interventions: DEVICE: WATCHMAN Left Atrial Appendage Occlusion Device|DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Catheter-directed Thrombolysis in Intermediate-high Risk Acute Pulmonary Embolism
Status: RECRUITING
Conditions: Pulmonary Embolism
Interventions: DRUG: Thrombolytic|DRUG: Standard anticoagulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn How a Proton Pump Inhibitor Affects the Way Elinzanetant (BAY 3427080) Moves Into, Through and Out of the Body, and How Much of it Gets Absorbed by the Body When Taken as a Single and Small Radioactive Dose in Healthy Adults
Status: COMPLETED
Conditions: Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men|Hot Flashes
Interventions: DRUG: Elinzanetant (BAY3427080)|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: TACE Combined With Immune Checkpoint Inhibitors for Liver Malignant Tumors
Status: RECRUITING
Conditions: Hepatocellular Carcinoma Non-resectable|Cholangiocarcinoma Non-resectable|Liver Metastases|Liver Malignant Tumors
Interventions: PROCEDURE: TACE with ICI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurocognitive Effectiveness in Treatment of First-episode Non-affective Psychosis: 1-year Follow-up
Status: COMPLETED
Conditions: Schizophrenia|Psychotic Disorders
Interventions: DRUG: Aripiprazole|DRUG: Quetiapine|DRUG: Ziprasidone|BEHAVIORAL: Cognitive battery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress
Status: NOT_YET_RECRUITING
Conditions: Prematurity|Respiratory Disease|Ventilator Lung; Newborn
Interventions: DRUG: Caffeine citrate|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection
Status: TERMINATED
Conditions: Acetaminophen Overdose
Interventions: DRUG: Acetadote EF (Ethylenediaminetetraacetic Acid (EDTA) - Free)|DRUG: Acetadote
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Status: COMPLETED
Conditions: Musculoskeletal Pain|Pain, Chronic
Interventions: OTHER: MRI Neuroimaging|OTHER: Quantitative Sensory Testing|OTHER: Questionnaires|OTHER: Physical and Cognitive Function Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CD19-CAR_Lenti T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and DLBCL or PML
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Diffuse Large B Cell Lymphoma|Primary Mediastinal Lymphoma
Interventions: BIOLOGICAL: CD19-CAR_Lenti T cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Learn About the Effects of Two Study Medicines (Maplirpacept [PF-07901801] And Glofitamab) When Given Together In People With Relapsed Or Refractory Diffuse Large B Cell Lymphoma.
Status: RECRUITING
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: DRUG: maplirpacept (PF-07901801)|DRUG: Glofitamab|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-cell Receptor α/β Depleted Donor Lymphocyte Infusion
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoid Leukemia, Acute|Myeloid Malignancy|Plasma Cell Tumor
Interventions: BIOLOGICAL: T-cell Receptor α/β Depleted Donor Lymphocyte Infusions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Social Anxiety: Combining Parent-child Treatment
Status: RECRUITING
Conditions: Social Anxiety Disorder of Childhood
Interventions: OTHER: Denken + Doen = Durven|OTHER: Supportive Parenting for Anxious Childhood Emotions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repair of Tympanic Membrane Perforation Using Tachosil Under Local Anesthesia
Status: UNKNOWN
Conditions: Tympanic Membrane Perforation
Interventions: PROCEDURE: Tachosil|PROCEDURE: fascia and cartilage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of RVU120 Combined With Venetoclax for Treatment of Relapsed/Refractory AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: RVU120|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Teriflunomide in Reducing the Frequency of Relapses and Accumulation of Disability in Patients With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: Teriflunomide|DRUG: Placebo (for teriflunomide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peanut Protein Supplementation to Prevent Muscle Atrophy and Improve Recovery Following Total Knee Arthroplasty
Status: TERMINATED
Conditions: Surgery
Interventions: DIETARY_SUPPLEMENT: Peanut Protein Powder|OTHER: Standard Care by Surgeon and Physical Therapist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Surfactant and Perinatal Risk Factors in NRDS With Different Gestational Ages
Status: UNKNOWN
Conditions: Infant, Newborn, NRDS
Interventions: DRUG: Surfactant, Pulmonary，Curosurf|OTHER: Perinatal risk factors of NRDS
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products
Status: COMPLETED
Conditions: Nicotine Dependence, Cigarettes
Interventions: DRUG: Nicotine patch|OTHER: Placebo patch|OTHER: E-cigarettes|OTHER: Non-nicotine e-cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Phenylbutyrate Therapy for Patients With Pyruvate Dehydrogenase Complex Deficiency.
Status: COMPLETED
Conditions: Pyruvate Dehydrogenase Complex Deficiency
Interventions: DRUG: sodium phenylbutyrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Antihypertensive Medication Timing on Morbidity and Mortality
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Use of blood pressure lowering medication at bedtime|OTHER: Use of blood pressure lowering medication in the morning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NUC-1031 in Patients With Platinum-Resistant Ovarian Cancer
Status: TERMINATED
Conditions: Ovarian Cancer
Interventions: DRUG: NUC-1031 500 mg|DRUG: NUC-1031 750mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Lazertinib|DRUG: Amivantamab|DRUG: Carboplatin|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab for Chronic Graft-versus-Host Disease Treatment
Status: WITHDRAWN
Conditions: Graft Versus Host Disease
Interventions: BIOLOGICAL: tocilizumab|OTHER: laboratory biomarker analysis|OTHER: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Exposure to Food in Social Networks on Food Cravings and External Eating
Status: COMPLETED
Conditions: Eating Habits and Behaviors, (UMLS)
Interventions: BEHAVIORAL: Exposure to pictures of appetizing food (known as Foodporn)|BEHAVIORAL: Exposure to neutral pictures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase II Study of Preoperative IMRT Combined With Capecitabine and Bevacizumab in Locally Advanced Rectal Cancer
Status: UNKNOWN
Conditions: Locally Advanced Malignant Neoplasm
Interventions: RADIATION: chemoradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Appropriate Dosing to Optimise Personalised Cancer Treatments
Status: COMPLETED
Conditions: Melanoma Stage III|Melanoma Stage IV|Ovarian Cancer|Renal Cancer Stage III|Renal Cancer Stage IV|Lung Cancer, Non-small Cell
Interventions: DIAGNOSTIC_TEST: Dried blood Spot (DBS)|DIAGNOSTIC_TEST: Venous blood sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Preliminary Study of the Efficacy and Safety of MK-8521 for Type 2 Diabetes (MK-8521-004)
Status: TERMINATED
Conditions: Type II Diabetes Mellitus
Interventions: DRUG: MK-8521|DRUG: Placebo|DRUG: Liraglutide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does the Wording of Text Message Reminders Improve Uptake in Breast Screening?
Status: TERMINATED
Conditions: Breast Cancer|Breast Disease
Interventions: OTHER: Intervention A - Behavioural Regulation|OTHER: Intervention B - Priority
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: South African Male User Research on Acceptability of Implants and Injections
Status: ACTIVE_NOT_RECRUITING
Conditions: Acceptability
Interventions: OTHER: Placebo injection: Intralipid 20% fat emulsion|OTHER: Placebo implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-diabetic Chronic Kidney Disease
Interventions: DRUG: Finerenone (BAY94-8862)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pazopanib in Comparison to Pemetrexed in Maintenance Setting in Non-progressing Subjects With Metastatic Stage IVA and IVB Non-squamous Non-small Cell Lung Cancer (NSCLC) Population
Status: TERMINATED
Conditions: Lung Cancer, Small Cell
Interventions: DRUG: pazopanib|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Antistax® in Improving Microcirculation of the Skin in the Leg in Patients Suffering From Chronic Venous Insufficiency
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DRUG: Antistax®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: dTMS for Subjective Cognitive Decline
Status: RECRUITING
Conditions: Alzheimer Disease|Subjective Cognitive Decline
Interventions: DEVICE: Active Brainsway H7-Coil Deep TMS System|DEVICE: Sham Brainsway H7-Coil Deep TMS System|OTHER: Cognitive Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: VCH-222 or matching placebo|DRUG: VCH-222 or matching placebo|BIOLOGICAL: peginterferon alfa-2a|DRUG: ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD
Status: COMPLETED
Conditions: Chronic Musculoskeletal Pain|Posttraumatic Stress Disorder (PTSD)|Mild or Moderate Traumatic Brain Injury
Interventions: BEHAVIORAL: Exercise Testing and Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Multiple Dose Study of Tezepelumab (AMG 157) in Adults With Mild Atopic Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|BIOLOGICAL: Tezepelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ELECTOR Treat-to-target Via Home-based Disease Activity Monitoring of Patients With Rheumatoid Arthritis
Status: WITHDRAWN
Conditions: Arthritis, Rheumatoid|Telerehabilitation
Interventions: DEVICE: Homebased disease monitoring (eHealth)|OTHER: Standard clinical disease monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Muscle Strength by Transcutaneous Electrical Stimulation
Status: RECRUITING
Conditions: Muscle Weakness
Interventions: DIAGNOSTIC_TEST: Transcutaneous electrical stimulation|DIAGNOSTIC_TEST: Magnetic stimulation|DIAGNOSTIC_TEST: ultrasound measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Double-Blind Phase 2 Study of Allogeneic HB-adMSCs for the Treatment of Chronic Post-COVID-19 Syndrome
Status: COMPLETED
Conditions: Post COVID-19 Syndrome
Interventions: BIOLOGICAL: HB-adMSCs (allogeneic)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: M1774 Human Mass Balance Study (DDRIVER Solid Tumors 303)
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: M1774 [14C]M1774 microtracer|DRUG: M1774
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of WX390 Combined With Toripalimab in Patients With Advanced Gastric-type Endocervical Adenocarcinoma With STK11 Mutations
Status: RECRUITING
Conditions: Gastric Type Adenocarcinoma (GAS) With STK11 Mutation
Interventions: DRUG: WX390|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Confirmatory Phase II/III Study Assessing Efficacy, Immunogenicity and Safety of IC43
Status: COMPLETED
Conditions: Pseudomonas Aeruginosa Infection
Interventions: BIOLOGICAL: IC43|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis
Status: UNKNOWN
Conditions: Multiple Sclerosis|Optic Neuritis
Interventions: DEVICE: Transorbital electrical stimulation (Eyetronic Next Wave 1.1)|DEVICE: Transorbital electrical stimulation (Eyetronic Next Wave 1.1) - Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Budesonide Efficacy on Nasal FeNO in Children With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Budesonide nasal spray (100 mcg bid)|DRUG: Budesonide nasal spray (50 mcg bid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis
Status: RECRUITING
Conditions: Spondyloarthritis
Interventions: OTHER: Blood sampling|OTHER: synovial aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prospective Study on Primary Aldosteronism in Resistant Hypertension
Status: RECRUITING
Conditions: Resistant Hypertension|Primary Aldosteronism|Refractory Hypertension|Hypertensive End-Organ Damage|Atrial Fibrillation|Aortic Ectasia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Efficacy of De-epithelialized Free Gingival Graft on Treatment of Multiple Gingival Recessions With Tunnel Technique
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: DGG + TUN|PROCEDURE: SCTG + TUN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect Of Plyometric Training On Balance And Proprioception In Different Branches Athletes
Status: COMPLETED
Conditions: Athlete Foot
Interventions: OTHER: The effect of plyometric training on balance and proprioception in athletes in different branches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety Study of Budesonide to Treat Oral Chronic Graft vs Host Disease (cGvHD)
Status: COMPLETED
Conditions: Oral Chronic Graft vs Host Disease
Interventions: DRUG: Budesonide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EPOCH Chemotherapy +/- IL-12 for Previously Untreated and EPOCH Plus Rituximab for Previously Treated Patients With AIDS-Associated Lymphoma
Status: COMPLETED
Conditions: AIDS Related Lymphoma|AIDS-Associated Lymphoma
Interventions: BIOLOGICAL: Filgrastim|BIOLOGICAL: Rituximab|DRUG: EPOCH
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis
Status: NOT_YET_RECRUITING
Conditions: Effective Intracanal Medicaments Against Enterococcus Faecalis
Interventions: DRUG: Ibuprofen 400 mg.|DRUG: modified triple antibiotic paste|DIETARY_SUPPLEMENT: curcumin|DIETARY_SUPPLEMENT: olive leaves extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Influence on Cough and Airway Symptoms by Oral Capsaicin
Status: ACTIVE_NOT_RECRUITING
Conditions: Cough
Interventions: DRUG: Capsicum Oleoresin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)
Status: RECRUITING
Conditions: Locally Advanced (Inoperable) or Metastatic Breast Cancer
Interventions: DRUG: Capivasertib|DRUG: Fulvestrant|DRUG: Palbociclib|DRUG: Ribociclib|DRUG: Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Snodgrass Versus Grafted Snodgrass Repair in Narrow Urethral Plate in Distal Penile Hypospadias
Status: RECRUITING
Conditions: Hypospadias
Interventions: PROCEDURE: Snodgrass repair|PROCEDURE: Snodgrass repair with graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure
Status: RECRUITING
Conditions: Acute-On-Chronic Liver Failure
Interventions: DRUG: standard medical treatment|DRUG: Placebo|DRUG: hUC-MSC|DRUG: hUC-MSC_Prolonged
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptation in Lower Extremity After 3 Running Days, With a Group Trained by Eccentric Overload
Status: COMPLETED
Conditions: Sports Injuries
Interventions: OTHER: Control|OTHER: Eccentric Overload
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: CERE-110: Adeno-Associated Virus injection Surgery|PROCEDURE: Placebo Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Cabotegravir Long-acting in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus|HIV Infections
Interventions: DRUG: Cabotegravir tablet 30 mg once daily for 28 days.|DRUG: Cabotegravir injection 3 mL (200 mg/mL) IM given once on Day 1.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Platelet-Rich Plasma Injections for Vocal Fold Atrophy, Scar, and/or Sulcus Vocalis
Status: COMPLETED
Conditions: Presbylarynx|Atrophy; Larynx|Dysphonia|Vocal Cord Atrophy|Presbylarynges|Vocal Fold Scar|Sulcus Vocalis of Vocal Cord
Interventions: PROCEDURE: Serial PRP injections
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial
Status: TERMINATED
Conditions: Bacteremia
Interventions: DRUG: Telavancin|DRUG: Vancomycin|DRUG: Daptomycin|DRUG: Synthetic penicillin|DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Window Opportunity Study With Giredestrant or Tamoxifen in Premenopausal Women With ER+/HER2[-] & Ki67≥10%
Status: RECRUITING
Conditions: Breast Cancer|Breast Cancer, Early-Onset
Interventions: DRUG: Giredestrant|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR
Status: COMPLETED
Conditions: Heart Valve Diseases|Mitral Valve Insufficiency|Heart; Dysfunction Postoperative, Cardiac Surgery|Heart; Disease, Mitral(Valve)|Diseases of Mitral Valve
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pilot Study Comparing Two Techniques of Taking Care Analgesic in Patients 70 and Older, Awaiting Surgery After Extracapsular Fracture of the Proximal Femur
Status: COMPLETED
Conditions: Femoral Fractures
Interventions: OTHER: traction-stuck|OTHER: a pillow between the legs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Split-belt Treadmill Training on Gait in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Freezing of Gait
Interventions: BEHAVIORAL: SBT|BEHAVIORAL: TBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT