pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Clinical Study to Evaluate the Pharmacokinetic Profiles and Safety of CKD-333 Low Dose in Healthy Volunteers
Status: UNKNOWN
Conditions: Cardiovascular Disease
Interventions: DRUG: CKD-330 Tab. and D090 Tab.|DRUG: CKD-333 Tab.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medico-economic Impact of Screening Atopobium Vaginae and Gardnerella Vaginalis in Molecular Biology by "Point-of-care" During Pregnancy
Status: COMPLETED
Conditions: Low Risk of Preterm Delivery
Interventions: OTHER: -self-collected vaginal samples|DRUG: zithromax|OTHER: usual practices
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Ibrutinib in Combination With Bendamustine and Rituximab for Patients With Relapsed/Refractory Aggressive BCL
Status: UNKNOWN
Conditions: Diffuse Large B Cell Lymphoma|Primary Mediastinal (Thymic) Large B-cell Lymphoma|Transformed Indolent Lymphoma|Recurrent Disease|Refractory Cancer
Interventions: DRUG: Bendamustine 90 mg/m2 IV on Days 1-2, Cycles 1-6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-modality Imaging in Peritoneal Carcinomatosis of Colorectal Origin
Status: UNKNOWN
Conditions: Peritoneal Carcinomatosis|Colorectal Cancer|Carcinoma|Neoplasms|Gastrointestinal Cancer
Interventions: DRUG: Indium-111-DOTA-Labetuzumab-IRDye800CW injection|RADIATION: SPECT/CT scan|PROCEDURE: CRS extended with dual-modality imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The IN.PACT SFA Clinical Study for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery and/or Proximal Popliteal Artery Using the IN.PACT Admiral™ Drug-Eluting Balloon in a Chinese Patient Population
Status: COMPLETED
Conditions: Atherosclerosis
Interventions: DEVICE: IN.PACT Admiral Paclitaxel-Eluting Percutaneous Transluminal Angioplasty (PTA) Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sedation on Clinical, Gasometric and Respiratory Muscle Parameters in Critically Ill COPD Patients
Status: COMPLETED
Conditions: Sedation in Critically Ill COPD Patients
Interventions: DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Intrauterine Growth Retardation in Burkina Faso: the Malaria Component
Status: COMPLETED
Conditions: Malaria|Malaria in Pregnancy
Interventions: DIETARY_SUPPLEMENT: Multiple micronutrients supplements (MMS)|DIETARY_SUPPLEMENT: Iron and folic acid (IFA)|DRUG: Chloroquine (CQ)|DRUG: Sulphadoxyne-pyrimethamine (SP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Methadone Hydrochloride as First-Line Therapy in Treating Patients With Chronic Neuropathic Cancer Pain
Status: TERMINATED
Conditions: Nausea and Vomiting|Pain|Sleep Disorders|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: methadone hydrochloride|OTHER: questionnaire administration|PROCEDURE: management of therapy complications
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions
Status: COMPLETED
Conditions: TBI|Major Depression|Other Psychiatric Disorders
Interventions: DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Improve Diabetes Management Among Adults Experiencing Severe Hypoglycemia
Status: SUSPENDED
Conditions: Diabetes|Hypoglycemia|Diabetes Type 1|Diabetes Type 2
Interventions: OTHER: Community Paramedic Program|OTHER: Education Material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study To Estimate The Effect of PF-06650833 On The Pharmacokinetics (PK) of Oral Contraceptive (OC)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PF-06650833|DRUG: Ethinyl estradiol (EE) and levonogestrel (LN)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluating Clinical Evaluation Tools for Predicting Risk of Complications After Hematopoietic Stem Cell Transplant
Status: RECRUITING
Conditions: Hematopoietic and Lymphoid System Neoplasm|Malignant Solid Neoplasm
Interventions: OTHER: Clinical Evaluation|OTHER: Electronic Health Record Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Computerized Cognitive Training and Stimulant Medication in Neurofibromatosis Type 1
Status: COMPLETED
Conditions: Neurofibromatosis Type 1
Interventions: OTHER: CogmedRM|OTHER: Mobymax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM)
Status: COMPLETED
Conditions: Dilated Cardiomyopathy|Heart Failure
Interventions: BIOLOGICAL: Stem cell therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimization of Parameters of Subthalamic Nucleus Stimulation
Status: WITHDRAWN
Conditions: Parkinson Disease
Interventions: DEVICE: biphasic stimulation|DEVICE: standard stimulation|DEVICE: Uniform distribution|DEVICE: Poisson distribution|DEVICE: Recordings of LFP oscillations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Zingiber Officinalis (Homoeopathic Medicine) in Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Zingiber officinalis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in North Macedonia Investigating Retrospective Data of Glucagon-like Peptide-1 (GLP-1) Participants With Type 2 Diabetes (T2D) in Real World Environment (RWE) Setting (MIRAGE)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Miransertib (MK-7075) in Participants With PIK3CA-related Overgrowth Spectrum and Proteus Syndrome (MOSAIC) (MK-7075-002)
Status: TERMINATED
Conditions: PIK3CA-Related Overgrowth Spectrum (PROS)/Proteus Syndrome
Interventions: DRUG: Miransertib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Examine the Efficacy and Safety of Posaconazole When Introduced Early in the Treatment of Refractory Fungal Infections (P05090 AM2)
Status: COMPLETED
Conditions: Mycoses
Interventions: DRUG: Posaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Aquatic-Based Plyometric Exercises for Patients With Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: OTHER: Aqua-Plyometric Exercise|OTHER: Standard physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rituximab, Combination Chemotherapy, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed Follicular Non-Hodgkin Lymphoma
Status: TERMINATED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisolone|DRUG: vincristine sulfate|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Treatment of Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: DEVICE: 1064 nm long-pulse Nd:YAG laser|DEVICE: 1064 nm long-pulse Nd:YAG laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sunitinib in Recurrent and/or Metastatic Adenoid Cystic Carcinoma of the Salivary Glands
Status: COMPLETED
Conditions: Adenoid Cystic Carcinoma|Salivary Gland Cancer
Interventions: DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Hepatectomy or TILA-TACE in Patients With Resectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Surgical Resection|HCC
Interventions: PROCEDURE: TILA-TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4 Dimensional - Impairment of Posttraumatic Forearm Rotation Evaluated With Computed Tomography
Status: COMPLETED
Conditions: Pronation-Supination of the Forearm, Impairment of
Interventions: DIAGNOSTIC_TEST: 4D-CT-scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Long Term Study of Sibutramine and the Role of Obesity Management in Relation to Cardiovascular Disease in Overweight and Obese Patients
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Sibutramine hydrochloride|DRUG: Placebo|DRUG: Sibutramine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quantifying Muscle Tone in Patients With Brain Injury - a Feasibility Study
Status: UNKNOWN
Conditions: Treatment Outcome|Muscle Dystonia|Spasticity, Muscle|Muscle Tightness|Acquired Brain Injury|Muscle Tone Abnormalities
Interventions: DRUG: Botulinum toxin type A injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preschool Literacy Screening: Validating a 5 Question Survey Using the GRTR-R and the Efficacy of Literacy-promoting Interventions
Status: WITHDRAWN
Conditions: Early Childhood Literacy
Interventions: OTHER: Literacy promoting home based program|OTHER: Literacy Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Modafinil for Freezing of Gait (FOG) in Parkinson's Disease (PD)
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: modafinil 50mg|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Vestibular Rehabilitation - a Randomized Controlled Trial
Status: COMPLETED
Conditions: Dizziness|Nausea|Nystagmus|Vestibular Diseases
Interventions: BEHAVIORAL: Vestibular rehabilitation|OTHER: standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depressive Episode
Status: COMPLETED
Conditions: Bipolar I Disorder
Interventions: DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Popliteal Block and Bupivacaine Concentration Used for Analgesia in Foot and Ankle Surgery
Status: COMPLETED
Conditions: Foot and Ankle Surgery|Popliteal Nerve Block|Peripheral Nerve Block
Interventions: DRUG: Bupivacaine|DRUG: Only spinal anesthesia without peripheral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Outcomes of Orthopaedic Surgery Using Gait Laboratory Versus Observational Gait Analysis in Children With Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: OTHER: Routine Observational Analysis (prior to procedure)|OTHER: Routine Observational analysis supplemented with Gait Lab Information (prior to procedure)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Tolerability, Safety and Efficacy of the HAC-Coil Deep Transcranial Magnetic Stimulation in Medication Resistance Obsessive Compulsive Disorder (OCD) Subjects
Status: UNKNOWN
Conditions: Obsessive Compulsive Disorder
Interventions: DEVICE: Deep TMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: EEG Based BCI for Upper Limb Rehabilitation in Stroke
Status: UNKNOWN
Conditions: Stroke Sequelae|Brain Ischemia
Interventions: OTHER: EEG -BCI based Feedback for rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open, Multicentric Trial Evaluating the Efficacy and the Clinical Tolerance of PA0903 as Root Canal Sealer
Status: COMPLETED
Conditions: Root Canal Obturation
Interventions: DEVICE: Pulp Canal Sealer (Kerr)|DEVICE: PA0903
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease
Status: TERMINATED
Conditions: GVHD,Acute
Interventions: DRUG: Itacitinib|DRUG: Prednisone|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib in Combination With Trastuzumab in Metastatic HER2 Positive Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer|Breast Carcinoma|HER-2 Positive Breast Cancer
Interventions: DRUG: Ruxolitinib|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Intermittent Preventive Treatment for Malaria in Children
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: artesunate-amodiaquine|DRUG: sulphadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Lipopolysaccharide Binding Protein and Development of Infectious Events in Cirrhotic Patients
Status: WITHDRAWN
Conditions: Cirrhosis|Ascites|Infections
Interventions: DRUG: Ciprofloxacin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Minding GOALS: An Internet-Assisted Mind-Body-Behavior Program for Blood Pressure Control
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: GOALS|BEHAVIORAL: Minding GOALS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Percutaneous Vertebral-disc Plasty for Thoracolumbar Very Severe Osteoporotic Vertebral Compression Fractures
Status: RECRUITING
Conditions: Osteoporotic Fracture of Vertebra
Interventions: PROCEDURE: percutaneous vertebral-disc plasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity and Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Advanced Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Neoplasm|Fatigue|Metastatic Malignant Neoplasm|Recurrent Malignant Neoplasm|Refractory Malignant Neoplasm
Interventions: DRUG: Dexamethasone|BEHAVIORAL: Exercise Intervention|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Supervised and Unsupervised Physical Activity Programs During a Weight Loss Intervention for Adults
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Supervised (SUP-PA)|BEHAVIORAL: Unsupervised (UNSUP-PA)|BEHAVIORAL: Step-based (STEP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors
Status: COMPLETED
Conditions: Extragonadal Germ Cell Tumor|Teratoma|Testicular Germ Cell Tumor
Interventions: BIOLOGICAL: bleomycin sulfate|BIOLOGICAL: pegfilgrastim|DRUG: cisplatin|DRUG: etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Preeclampsia Research on Vitamin D, Inflammation, & Depression
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre-Eclampsia|Depression|Inflammation|Vitamin D Deficiency
Interventions: OTHER: mental health screening, education and referral program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Hydroquinidine Versus Placebo in Patients With Brugada Syndrome
Status: TERMINATED
Conditions: Brugada Syndrome
Interventions: DRUG: hydroquinidine|DRUG: placebo (sugar)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical KB105 Gene Therapy for the Treatment of TGM1-deficient Autosomal Recessive Congenital Ichthyosis (ARCI)
Status: ACTIVE_NOT_RECRUITING
Conditions: TGM-1 Related Autosomal Recessive Congenital Ichthyosis
Interventions: BIOLOGICAL: KB105
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Acapella With Conventional Chest Physiotherapy Techniques in Post CABG Patients.
Status: COMPLETED
Conditions: Cardiac Procedure Complication
Interventions: DEVICE: Acapella device|OTHER: Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Vildagliptin vs Sitagliptin add-on to Insulin - Impact on Glycemic Profile and Correlation of Hypoglycemic Episodes and Heart Function
Status: COMPLETED
Conditions: Diabetes Mellitus Type 2
Interventions: DRUG: Vildagliptin|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis
Status: COMPLETED
Conditions: Actinic Cheilitis
Interventions: DRUG: aminolevulinic acid hydrochloride|PROCEDURE: Photodynamic therapy with blue light
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Efficacy and Safety of Tocilizumab Compared to DefeROxamine, Associated With Standards Treatments in COVID-19 (+) Patients Hospitalized In Intensive Care in Tunisia
Status: UNKNOWN
Conditions: COVID19|Intensive Care Unit
Interventions: DRUG: Tocilizumab Injection|DRUG: Deferoxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myotonia and Muscle Stiffness in NMD
Status: COMPLETED
Conditions: Neuromuscular Disorders
Interventions: DEVICE: MyotonPro|DIAGNOSTIC_TEST: Six-minute walk test|DIAGNOSTIC_TEST: Semiquantitative muscle ultrasound|DIAGNOSTIC_TEST: Hand-held Dynamometry of muscle strength
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve
Status: UNKNOWN
Conditions: Aortic Valve Stenosis|Aortic Valve Insufficiency|Transcatheter Aortic Valve Replacement
Interventions: DEVICE: Transcatheter aortic valve implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML
Status: RECRUITING
Conditions: Myelodysplastic Syndromes|Secondary Acute Myeloid Leukemia|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Venetoclax|DRUG: Amsacrine|DRUG: Ara-C|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Causal Role of Top-Down Theta Oscillations in Prioritization
Status: ENROLLING_BY_INVITATION
Conditions: Working Memory|Epilepsy
Interventions: DEVICE: Direct cortical stimulation (DCS) Alpha|DEVICE: Direct cortical stimulation (DCS) Theta|DEVICE: Sham Direct cortical stimulation (DCS)|DEVICE: Direct cortical stimulation (DCS) In-Phase Theta|DEVICE: Direct cortical stimulation (DCS) Anti-Phase Theta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Oral PTK787 in Patients With Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Wet Age-Related Macular Degeneration
Interventions: DRUG: PTK787|DRUG: PTK787|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validating the Safety and Effectiveness of ENDOANGEL Lower Gastrointestinal Endoscope Image Auxiliary Diagnostic Software
Status: COMPLETED
Conditions: Intestinal Polyps
Interventions: OTHER: Endoangel assisted the process of colonoscopy|OTHER: Colonoscopy was performed without endoangel assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of a Video-Based Media Series to Promote Effective Parenting
Status: COMPLETED
Conditions: Childhood Disruptive Behavior Problems
Interventions: BEHAVIORAL: Triple P Media Series -- Standard "Information-Only" version|BEHAVIORAL: Triple P Media Series -- Enhanced "Behavior Activation" version
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Novel Dental Gel as an Adjunct to Scaling and Root Planing
Status: RECRUITING
Conditions: Periodontal Diseases|Gingival Diseases|Gingival Pocket|Gum Bleed|Plaque, Dental
Interventions: OTHER: SRP + Livfresh Dental Gel|OTHER: SRP + standard flouride dentifrice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ADELANTE: A Randomized Controlled Trial to Improve Engagement in Care for Latinos With HIV
Status: RECRUITING
Conditions: HIV/AIDS
Interventions: BEHAVIORAL: ADELANTE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I Study of Weekly Topotecan in Combination With Sorafenib in Treatment of Relapsed Small Cell Lung Cancer
Status: COMPLETED
Conditions: Small Cell Carcinoma|Lung Cancer
Interventions: DRUG: Topotecan|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation Therapy in Essential Tremor
Status: RECRUITING
Conditions: Essential Tremor
Interventions: DEVICE: real rTMS|DEVICE: sham rTMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Edotecarin and Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: cisplatin|DRUG: edotecarin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short-term Behavior Change With Pedal Desk Installation
Status: TERMINATED
Conditions: Physical Activity in the Workplace
Interventions: BEHAVIORAL: Self-Directed Pedal Desk|BEHAVIORAL: Facilitated Pedal Desk|BEHAVIORAL: Facilitated Pedal Desk with Pedometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Social Worker-led Mindfulness-based Intervention for Older People
Status: RECRUITING
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Mindfulness-based intervention (MBI) (enhanced with peer supporters)|BEHAVIORAL: Experimental: social worker-led MBI (without peer supporters)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Second Try During Landmark Approach of the Internal Jugular Vein: an Ultrasonographic Prelocation Study
Status: NOT_YET_RECRUITING
Conditions: Jugular Veins
Interventions: DEVICE: Ultrasonography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacodynamics of SYNB1353 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Homocystinuria
Interventions: DRUG: SYNB1353
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Carvedilol VS Endoscopic Therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding
Status: UNKNOWN
Conditions: Liver Cirrhosis|Esophageal and Gastric Varices
Interventions: DRUG: Carvedilol|DEVICE: endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine in Long Infusion and Cisplatin for Malignant Pleural Mesothelioma Treatment
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Prolonged 6-hr infusion of gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Sex Steroids on the Serotonin System
Status: UNKNOWN
Conditions: Gender Dysphoria
Interventions: DRUG: Testosterone|DRUG: Lynestrenol|DRUG: Cyproterone Acetate|DRUG: Estradiol|DRUG: Triptorelin acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SXC-2023 Cocaine Interaction Study
Status: NOT_YET_RECRUITING
Conditions: Cocaine Use Disorder
Interventions: DRUG: SXC-2023|DRUG: SXC-2023 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy and Safety of Co-administrated Rosuvastatin/Ezetimibe and Telmisartan
Status: COMPLETED
Conditions: Hypercholesterolemia|Hypertension
Interventions: DRUG: Ezetimibe/Rosuvastatin|DRUG: Telmisartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers
Status: COMPLETED
Conditions: Colorectal Cancer|Squamous Cell Head and Neck Cancer|Non-small Cell Lung Cancer|Triple Negative Breast Cancer|Other Tumors With EGFR Dependence
Interventions: DRUG: MM-121|DRUG: Irinotecan|DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accuracy of the Thoracic Epidural Catheter Insertion Confirmed by Fluoroscopic Imaging
Status: UNKNOWN
Conditions: Patients Undergoing Thoracic Surgery|Patients Undergoing Upper Abdominal Surgery
Interventions: PROCEDURE: Fluoroscopic imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Wide-field Retinal Imaging
Status: UNKNOWN
Conditions: Retinal Disease
Interventions: DEVICE: extent of retinal area viewing Optos, Daytona, Optos PLC, Dunfermline, UK|DEVICE: extent of retinal area viewing Clarus, 500 Carl Zeiss, Meditec AG, Jena, Germany
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Slow Digestible Carbohydrates and Exercise in Adolescents With Type 1 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes|Hypoglycemia
Interventions: DIETARY_SUPPLEMENT: maltodextrin|DIETARY_SUPPLEMENT: super starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study STF115288, a Clinical Confirmation Study of GI148512 in the Treatment of Acne Vulgaris in Japanese Subjects
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: GI148512|DRUG: vehicle gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Dose Escalation Study of Intra-Articular Administration of tgAAC94
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: GENETIC: tgAAC94 gene therapy vector|GENETIC: tgAAC94 gene therapy vector|GENETIC: tgAAC94 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni)
Status: COMPLETED
Conditions: Schistosomiasis
Interventions: DRUG: Biltricide (racemate praziquantel) oral tablets|DRUG: Racemate Praziquantel ODT|DRUG: Levo Praziquantel ODT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nutrition and Physical Activity in Patients With Cerebrovascular Disease
Status: COMPLETED
Conditions: Cerebrovascular Disorders
Interventions: DIETARY_SUPPLEMENT: Conventional diet +/- wine|DIETARY_SUPPLEMENT: Luxembourg variant of Mediterranean diet + physical activity +/- wine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose:
Clinical trial: Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: Tauroursodeoxycholic acid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Two Silicone Hydrogel Toric Contact Lenses
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Lotrafilcon B toric contact lenses with HYDRAGLYDE|DEVICE: Lotrafilcon B toric contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect of Calories and Fat Content on the Pharmacokinetics of Lurasidone HCl
Status: COMPLETED
Conditions: Schizophrenia, Schizoaffective Disorder, or Schizophreniform Disorder
Interventions: DRUG: Lurasidone HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Cluster-randomized Trial to Assess a Sexual Assault Prevention Intervention in Adolescents in Nairobi, Kenya
Status: COMPLETED
Conditions: Sexual Assault and Rape|Violence, Non-accidental
Interventions: BEHAVIORAL: 12-hr "IMPower" empowerment self defense course|BEHAVIORAL: 12-hr Source of Strength for boys|BEHAVIORAL: Life-skills course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Depression and Cardiovascular Risk Markers: Effects of Rosuvastatin Therapy
Status: WITHDRAWN
Conditions: Depression
Interventions: DRUG: rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: How "Shared Decision Making Decision-aid" Help Patients With Obstructive Sleep Apnea to Choose Treatment Plan
Status: UNKNOWN
Conditions: Shared Decision Making|OSA - Obstructive Sleep Apnea
Interventions: OTHER: Decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Trial of Novel Oral Zinc Cysteine Preparation in Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: OTHER: Gastro-retentive zinc cysteine tablet|OTHER: Tablet identical physically to active comparator containing some lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Imaging and Reading Deficit in Children With NF1
Status: COMPLETED
Conditions: Neurofibromatosis Type 1
Interventions: OTHER: Neuropsychological assessments|RADIATION: morphological and functional MRI (fMRI)|GENETIC: genetic analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease
Status: COMPLETED
Conditions: Anemia|Hematologic Diseases|Cardiovascular Diseases|Heart Diseases|Myocardial Infarction|Thromboembolism|Pneumonia|Cerebrovascular Accident
Interventions: BIOLOGICAL: Liberal (10 g/dL) Transfusion Strategy|BIOLOGICAL: Restrictive (Symptomatic) Transfusion Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Image Guided Radiation Therapy in Treating Patients With Stage IV Breast Cancer
Status: COMPLETED
Conditions: Central Nervous System Metastases|Invasive Ductal Breast Carcinoma|Invasive Ductal Breast Carcinoma With Predominant Intraductal Component|Invasive Lobular Breast Carcinoma|Invasive Lobular Breast Carcinoma With Predominant in Situ Component|Liver Metastases|Lobular Breast Carcinoma in Situ|Lung Metastases|Male Breast Cancer|Medullary Ductal Breast Carcinoma With Lymphocytic Infiltrate|Mucinous Ductal Breast Carcinoma|Papillary Ductal Breast Carcinoma|Recurrent Breast Cancer|Stage IV Breast Cancer|Tubular Ductal Breast Carcinoma|Tumors Metastatic to Brain
Interventions: RADIATION: hyperfractionated radiation therapy|OTHER: laboratory biomarker analysis|RADIATION: stereotactic radiosurgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cell Therapy in Advanced Chronic Obstructive Pulmonary Disease Patients
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: PROCEDURE: Bone marrow harvesting|PROCEDURE: Liposuction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PLT and Steroid in Lateral Epicondylopathy and Supraspinatus Calcific Tendinopathy
Status: RECRUITING
Conditions: Lateral Epicondylitis|Rotator Cuff Syndrome
Interventions: COMBINATION_PRODUCT: lyophilized platelet (30ng) and triamcinolone acetonide 10mg|OTHER: lyophilized platelet (30ng)|DRUG: triamcinolone acetonide 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of DCA (Dichloroacetate) in Combination With Cisplatin and Definitive Radiation in Head and Neck Carcinoma
Status: COMPLETED
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: DRUG: DCA (dichloroacetate)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome
Status: UNKNOWN
Conditions: Intense-exuberant Stomach Fire Syndrom|Acute Pericoronitis|Recurrent Aphthous Stomatitis|Recurrent Herpes Simplex Labialis
Interventions: DRUG: Huanglian-Jiedu Decoction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Palbociclib or Tazemetostat in Combination With CPX-351 for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia
Interventions: DRUG: Tazemetostat|DRUG: Liposome-encapsulated Daunorubicin-Cytarabine|PROCEDURE: Bone Marrow Aspiration and Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of 852A in Metastatic Cutaneous Melanoma.
Status: COMPLETED
Conditions: Melanoma|Unresectable Metatstatic Cutaneous Melanoma
Interventions: DRUG: 852A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Psychological Wellness After Acquired Brain Injury
Status: UNKNOWN
Conditions: Depression|Anxiety|Brain Injury
Interventions: BEHAVIORAL: Cognitive Behavioural Therapy|BEHAVIORAL: Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Validate Metallic Markers for Image Guided Radiation Therapy for Breast Cancer Tx
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Non-contrast Computed Tomography (CT) Scans (Metallic Markers)|DEVICE: Non-contrast CT Scans (Metallic Markers)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability of Empagliflozin/Metformin Fixed Dose Combinations (FDCs) in Healthy Chinese Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 5 mg empagliflozin/850 mg metformin FDC|DRUG: 12.5 mg empagliflozin|DRUG: 12.5 mg empagliflozin|DRUG: 850 mg metformin|DRUG: 5 mg empagliflozin|DRUG: 5 mg empagliflozin|DRUG: 850 mg metformin|DRUG: 12.5 mg empagliflozin/850 mg metformin FDC|DRUG: 12.5 mg empagliflozin/500 mg metformin FDC|DRUG: 5 mg empagliflozin/500 mg metformin FDC|DRUG: 500 mg metformin|DRUG: 500 mg metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Black Seed Oil With Vonoprazan Based Triple Therapy in Treatment of Helicobacter Pylori
Status: RECRUITING
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Black Seed Oil Cap/Tab|DRUG: Vonoprazan, Amoxicillin and Clarithromycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BO-112 With Pembrolizumab in Unresectable Malignant Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: BO-112 plus pembrolizumab|PROCEDURE: Tissue Biopsies
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperbaric Oxygen and Manipulative Therapies to Regain Function Post Stroke
Status: COMPLETED
Conditions: Stroke|Motor Dysfunction|Chronic Stroke|Ischemic Stroke
Interventions: COMBINATION_PRODUCT: HBOT and OMT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Efficacy of Infiltration of Upper Cluneal Nerves in Chronic Pain Related to Cluneal Syndrome
Status: WITHDRAWN
Conditions: Cluneal Syndrome|Nerve Entrapment Syndrome
Interventions: DRUG: Ropivacaine injection|DRUG: Physiological serum injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) in Adults With Programmed Cell Death-Ligand 1 (PD-L1)-Positive Treatment-naïve Nonsmall Cell Lung Cancer (NSCLC) (MK-7902-007/E7080-G000-314/LEAP-007)
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Lenvatinib|DRUG: Placebo for lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Effectiveness of NVD-001 for the Treatment of Low Grade Degenerative Lumbar Spondylolisthesis
Status: COMPLETED
Conditions: Spondylolisthesis
Interventions: BIOLOGICAL: NVD-001|PROCEDURE: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Two Intradermal Rabies Vaccine Regimens Administered With and Without Human Rabies Immunoglobulin in Subjects ≥ 1 Years of Age
Status: COMPLETED
Conditions: Rabies Infection
Interventions: BIOLOGICAL: Rabies vaccine|BIOLOGICAL: Rabies vaccines + Rabies immunoglobulins|BIOLOGICAL: Rabies vaccine|BIOLOGICAL: Rabies vaccines + Rabies immunoglobulins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Does Yoga Done To Women With Premenstrual Syndrome Affect Inflammation Parameters?
Status: UNKNOWN
Conditions: Premenstrual Syndrome
Interventions: OTHER: yoga|OTHER: Routin control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery
Status: NOT_YET_RECRUITING
Conditions: Local Analgesia Via Nerve Block
Interventions: DRUG: Bupivacaine Liposome Injection|DRUG: Bupivacaine Hydrochloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of Calcium Balance in Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: High calcium diet 2000 mg/day|DIETARY_SUPPLEMENT: Low calcium diet, 800 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Concomitant Use and Staggered Use of Vaccine and Oral Poliovirus (OPV) in Healthy Infants (V260-014)(COMPLETED)
Status: COMPLETED
Conditions: Rotavirus Infections|Gastroenteritis
Interventions: BIOLOGICAL: Rotavirus Vaccine, Live, Oral, Pentavalent|BIOLOGICAL: Comparator: Oral Poliovirus Vaccine (OPV)|BIOLOGICAL: Comparator: Oral Poliovirus Vaccine (OPV) (staggered)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of HER2 Directed Dendritic Cell (DC1) Vaccine + Weekly Paclitaxel, Trastuzumab & Pertuzumab
Status: RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: BIOLOGICAL: HER-2 pulsed DC1|DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Paclitaxel|PROCEDURE: Resection surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Romosozumab (AMG 785) in Postmenopausal Women With Low Bone Mineral Density
Status: COMPLETED
Conditions: Low Bone Mineral Density|Postmenopausal Osteoporosis
Interventions: DRUG: Placebo to Romosozumab|DRUG: Alendronate|DRUG: Teriparatide|DRUG: Romosozumab|DRUG: Denosumab|DRUG: Placebo to Denosumab|DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Using an Hemodynamic Monitoring System on Anesthetic Consumption During Abdominal Surgery
Status: NOT_YET_RECRUITING
Conditions: Hypotension During Surgery
Interventions: DEVICE: Acumen IQ cuff
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT