pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Lomustine|DRUG: Imipramine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myo-inositol and an Antioxidant Mix for the Treatment of Vietnamese Infertile Men
Status: UNKNOWN
Conditions: Male Infertility
Interventions: DIETARY_SUPPLEMENT: Andrositol Plus|DIETARY_SUPPLEMENT: Andrositol Plus|DIETARY_SUPPLEMENT: Andrositol Plus|DIETARY_SUPPLEMENT: Andrositol Plus|DIETARY_SUPPLEMENT: Andrositol Plus|DIETARY_SUPPLEMENT: Andrositol Plus|DIETARY_SUPPLEMENT: Andrositol Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Fentanyl sublingual spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Novel Rehabilitation Approach: Dyadic Strategy Training for Stroke Survivors and Their Caregivers
Status: RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: Dyad-focused strategy training intervention|BEHAVIORAL: Attention-control intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Postconditioning by Cyclosporin A in Pulmonary Transplantation
Status: WITHDRAWN
Conditions: Lung Transplantation
Interventions: DRUG: Cyclosporine A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing a Synergistic Antimicrobial Cleanser and Gel to Normal Saline and an Amorphous Gel in Reducing Bioburden and Promoting Healing in Chronic Lower Extremity Ulcers
Status: ACTIVE_NOT_RECRUITING
Conditions: Wound of Skin
Interventions: DEVICE: Normal Saline and Amorphous gel|DEVICE: BIAKOS™ Antimicrobial Skin & Wound Cleanser, BIAKŌS Antimicrobial Wound Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Novartis Vaccine and Diagnostics Carriage Trial
Status: COMPLETED
Conditions: N. Meningitidis Carriage
Interventions: BIOLOGICAL: Meningococcal B Recombinant + Outer Membrane Vesicle vaccine (rMenB+OMV NZ)|BIOLOGICAL: MenACWY-CRM conjugate vaccine|BIOLOGICAL: Japanese Encephalitis vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Assessment of Insulin Glargine Versus LiraglutidE After Oral Agents Failure
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Insulin glargine|DRUG: Liraglutide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Central Analgesic Effects of Paracetamol on Serotonergic Pathways
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Paracetamol|DRUG: Tropisetron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 2D vs 3D Planning for High-Dose Rate (HDR) Gynecological Brachytherapy
Status: COMPLETED
Conditions: Cervix Cancer|Endometrial Cancer
Interventions: OTHER: 2D HDR planning|OTHER: 3D HDR planning
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Eltrombopag in Chronic Idiopathic Thrombocytopenic Purpura (ITP)
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura|Purpura, Thrombocytopenic, Idiopathic
Interventions: DRUG: Eltrombopag oral tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Plus Paclitaxel in Treating Patients With Stage IIB or Stage III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: paclitaxel|DRUG: tamoxifen citrate|PROCEDURE: surgical procedure|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: PSMA MRI Guided Prostate SBRT (ARGOS)/Comprehensive, Longitudinal Evaluation of Imaging Biomarkers Post Radiotherapy (CLIMBER)
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: RADIATION: High Intermediate Risk Patients|RADIATION: High Risk or Very High-Risk Patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rebif® Rebidose® Versus Rebiject II® Ease-of-Use
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DEVICE: Rebif Rebidose|DEVICE: Rebiject II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib/II Study of Efficacy and Feasibility of Cytoreductive Surgery, Extensive Peritoneal Lavage, Hyperthermicintraperitoneal Chemotherapy and Post-operative Intraperitoneal Chemotherapy Combination in Gastric Cancer With Peritoneal Metastasis
Status: COMPLETED
Conditions: Gastric Cancer With Peritoneal Metastasis (PCI<12)
Interventions: DRUG: CRS+HIPEC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System (SUMMIT MAX)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DEVICE: Route 92 Medical Reperfusion System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of BMS-275183 in Patients With Pretreated Locally Advanced or Metastatic NSCLC (Non Small Cell Lung Cancer)
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: BMS-275183 (oral taxane)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Plasma for Treatment of Facial Photoaging: A Double-blind, Randomized, Split-face Study
Status: UNKNOWN
Conditions: Platelet-Rich Plasma|Aging
Interventions: PROCEDURE: mesotherapy of platelet rich plasma and platelet poor plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis
Status: NOT_YET_RECRUITING
Conditions: Non-cystic Fibrosis Bronchiectasis
Interventions: DRUG: Nebulized Ensifentrine Suspension; 3 mg|DRUG: Nebulized Placebo Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clipless Laparoscopic Cholecystectomy Using Harmonic Scalpel in Cirrhotic Patients a Prospective Randomized Study
Status: COMPLETED
Conditions: Gall Bladder Stone in Cirrhotics
Interventions: PROCEDURE: LC was done using traditional method|PROCEDURE: LC was done using harmonic ACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lumbar Punctures in Neonates: Improving Success Rates and Minimizing Pain
Status: TERMINATED
Conditions: Meningitis
Interventions: DRUG: 1% lidocaine|DRUG: topical lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Iressa and CRT/IMRT in Chinese Patients With IIIB/IV NSCLC After Failure of Platinum-Based Chemotherapy
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Gefitinib|DEVICE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Care-Based Physical Activity for Diabetic Latinas
Status: TERMINATED
Conditions: Diabetes|Sedentary Lifestyle
Interventions: BEHAVIORAL: Tailored Physical Activity Intervention|BEHAVIORAL: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Muscle Soreness and Stiffness in Patients With Chronic or Frequent Episodic Tension Type Headache.
Status: COMPLETED
Conditions: Tension-type Headache
Interventions: DRUG: Amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: RCT Comparing Non-operative vs Operative Treatment of Suprasyndesmotic Ankle Fractures.
Status: ACTIVE_NOT_RECRUITING
Conditions: Ankle Fractures
Interventions: PROCEDURE: Surgical treatment|DEVICE: Ankle orthosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Splinting Versus Not Splinting of the Distal Lower Extremity After Intramedullary Nailing for Tibial Fractures
Status: COMPLETED
Conditions: Tibia Fracture
Interventions: PROCEDURE: Post-Op Splinting|PROCEDURE: No Splinting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Overcoming Psychomotor Slowing in Psychosis (OCoPS-P)
Status: COMPLETED
Conditions: Schizophrenia and Related Disorders|Schizophrenia|Schizoaffective Disorder|Brief Psychotic Disorder
Interventions: DEVICE: 1 Hz rTMS|DEVICE: iTBS|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q4-Atomoxetine
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Atomoxetine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy, Surgery, and Radiation Therapy in Treating Infants With Neuroblastoma
Status: UNKNOWN
Conditions: Neuroblastoma
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: vincristine sulfate|PROCEDURE: adjuvant therapy|PROCEDURE: conventional surgery|PROCEDURE: neoadjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS)
Status: COMPLETED
Conditions: Pain Management
Interventions: DRUG: Local anaesthetic|DRUG: Pudendal Nerve Block plus anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nonincised Papillae in the Treatment of Intrabony Defects.
Status: UNKNOWN
Conditions: Reconstructive Surgical Procedure
Interventions: PROCEDURE: Experimental- Nonincised papillae surgical approach|PROCEDURE: Active comparator- Entire papilla preservation technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inadvertent Hypothermia or Hyperthermia in Pediatric Radiotherapy Practices Under Anesthesia
Status: COMPLETED
Conditions: Hypothermia; Anesthesia|Hyperthermia, Anesthesia Related|Radiotherapy Side Effect|Childhood Cancer
Interventions: PROCEDURE: radiotherapy under anesthesia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacokinetics of a Single 14C-labeled Dose of Risedronate or Alendronate Followed by Once-a-week Unlabeled Oral Dose
Status: COMPLETED
Conditions: Osteopenia|Osteoporosis
Interventions: DRUG: risedronate|DRUG: alendronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Teaching Novel Values-Based Skills to Improve Long-Term Weight Loss
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)|BEHAVIORAL: Self-Regulation (SR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion
Status: COMPLETED
Conditions: Branch Retinal Vein Occlusion
Interventions: DRUG: Ranibizumab|PROCEDURE: Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Cancer Patients With Central Line Associated Clots in the Upper Extremity Treated With Rivaroxaban (Catheter 2)
Status: COMPLETED
Conditions: Neoplasm|Central Venous Catheter Thrombosis
Interventions: DRUG: Rivaroxaban
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Analysis of the Outcomes From Protocolized Perioperative Care for Patients Receiving Total Hip or Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Hip Osteoarthritis|Knee Arthritis|Hip Arthritis
Interventions: PROCEDURE: Total knee or Hip Arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Non-Operative Versus Operative Treatment for High-Energy Midshaft Clavicle Fractures
Status: COMPLETED
Conditions: High Energy Midshaft Clavicle Fractures
Interventions: PROCEDURE: ORIF with Plate and Screws|PROCEDURE: Pin Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-World Evidence (RWE) Long-Term Follow-Up Study to Assess Outcomes of Alcon Monofocal Intraocular Lenses
Status: ENROLLING_BY_INVITATION
Conditions: Aphakia
Interventions: DEVICE: AcrySof single-piece IOL|DEVICE: AcrySof multi-piece IOL
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Continuous Infusion and Bolus Doses of Rocuronium During Lumbal Discectomy, Muscle Strength and Patient Recovery
Status: COMPLETED
Conditions: Rocuronium|Lumbar Discectomy|Recovery
Interventions: DRUG: Rocuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effect Of Multiple Dose PF-06700841 On The Pharmacokinetics Of Single Dose Oral Contraceptive Steroids
Status: COMPLETED
Conditions: Healthy Female Volunteers
Interventions: DRUG: PF-06700841|DRUG: Ethinyl estradiol (EE) and levonorgestrel (LN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Endoscopic Scissors Cutting Nasobiliary Duct VS Bilateral Plastic Stent
Status: RECRUITING
Conditions: Cholangiocarcinoma, Hilar|Biliary Stricture|Hilar Cholangiocarcinoma|Klatskin Tumor|Biliary Disease|Bile Duct Diseases|Bile Duct Stenosis
Interventions: DEVICE: Endoscopic nasobiliary duct cutting|DEVICE: Bilateral plastic stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Post-operative Vomitings (POV) After Early Refeeding in Pediatric Day Case Surgery.
Status: UNKNOWN
Conditions: Post-operative Vomiting Incidence|Pediatric Day Case Surgery
Interventions: OTHER: early refeeding|OTHER: refeeding only in the recovery room (usual practice).
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress
Status: COMPLETED
Conditions: Respiratory Distress Syndrome, Newborn
Interventions: OTHER: Extubation to Nasal IPPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Vericiguat (BAY1021189)|DRUG: Placebo|DRUG: Nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RECOVERY: A Transdiagnostic Intervention for Anxiety and Depression
Status: UNKNOWN
Conditions: Depression|Dysthymic Disorder|Panic Disorder|Social Phobia|Generalized Anxiety Disorder|Specific Phobia
Interventions: BEHAVIORAL: Recovery (Transdiagnostic & self)|BEHAVIORAL: Transdiagnostic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Treatments for HIV-Infected Opioid Users in an Integrated Care Effectiveness Study (CHOICES) Scale-Up
Status: COMPLETED
Conditions: Opioid-use Disorder|Hiv
Interventions: DRUG: Naltrexone Injectable Suspension|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Opioid-use Disorder|Pain
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: Psychotherapy for Pain (I-STOP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Myofascial Pain Syndrome in Adolescent Idiopathic Scoliosis
Status: COMPLETED
Conditions: Scoliosis; Adolescence|Myofascial Pain Syndrome|Trigger Point Pain, Myofascial|Physical Medicine and Rehabilitation
Interventions: DIAGNOSTIC_TEST: physical examination and measurement of spinal alignment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Concurrent Chemoradiotherapy With Oral Vinorelbine in Patients With Non-small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Vinorelbine
Interventions: DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: De-implementation of Low-value Pharmacological Prescriptions
Status: ACTIVE_NOT_RECRUITING
Conditions: Inappropriate Prescribing|Implementation Science|Behavioral Sciences
Interventions: BEHAVIORAL: A non-reflective decision assistance strategy|BEHAVIORAL: A both reflective and non-reflective decision information strategy|BEHAVIORAL: A reflective decision structure strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fluvoxamine for Early Treatment of Covid-19 (Stop Covid 2)
Status: COMPLETED
Conditions: Covid19|Coronavirus
Interventions: DRUG: Fluvoxamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lenalidomide and Cetuximab in Treating Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Colon Cancer|Rectal Cancer
Interventions: DRUG: lenalidomide|BIOLOGICAL: cetuximab|OTHER: mutation analysis|OTHER: polymerase chain reaction|GENETIC: polymorphism analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating the Safety, Recovery, and Pharmacodynamics of Multiple Oral Administrations of SNIPR001 in Healthy Subjects
Status: COMPLETED
Conditions: E.Coli Infections|Bloodstream Infection
Interventions: DRUG: SNIPR001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Dronedarone on Atrial Fibrosis Progression and Atrial Fibrillation Recurrence
Status: TERMINATED
Conditions: Atrial Fibrillation|Atrial Fibrillation Recurrent
Interventions: DRUG: dronedarone 400 mg Oral Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Effects of Activia in IBS
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: Activia® (125g/pot)|DIETARY_SUPPLEMENT: Acidified non-fermented dairy product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter, Randomized Trial to Determine the Effect of Therapeutic Riding, on a Group of People With Arthritis
Status: COMPLETED
Conditions: Arthritis
Interventions: PROCEDURE: Horse-assisted therapy|PROCEDURE: Physical exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect on Early Somatic Growth of a Daily Kinesthetic Stimulation on Preterm Infants
Status: COMPLETED
Conditions: Preterm Infant|Growth Acceleration|Neurobehavioral Manifestations
Interventions: BEHAVIORAL: KS in Kangaroo Position|BEHAVIORAL: KS in incubator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Activity and Safety Study of BKM120 in Monotherapy in Patient With Metastatic Head and Neck Cancer Recurrent or Progressive
Status: COMPLETED
Conditions: Head and Neck Neoplasms|Neoplasm Metastasis|Recurrent Disease|Progressive Disease
Interventions: DRUG: BKM120
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Senior PharmAssist: Co-Design and Evaluation of a Toolkit to Promote Scalable Implementation
Status: COMPLETED
Conditions: Medication Therapy Management|Implementation Science
Interventions: OTHER: Senior PharmAssist^TM Program Implementation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Determine the Improvement of the Symptoms of Benign Prostatic Hyperplasia (BPH) When Switching Subjects From Proscar to Avodart
Status: UNKNOWN
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: Dutasteride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Sequence Intubation With Rocuronium-Sugammadex Compared With Succinylcholine
Status: COMPLETED
Conditions: Rapid Sequence Intubation
Interventions: DRUG: Rocuronium-Sugammadex|DRUG: Succinylcholine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Danoprevir/Ritonavir and Copegus With RO5024048 and/or Pegasys in Patients With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Copegus|DRUG: Copegus|DRUG: Pegasys|DRUG: Pegasys|DRUG: RO5024048|DRUG: danoprevir|DRUG: ritonavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Value of Abciximab in Patients With AMI Undergoing Primary PCI After Clopidogrel Pretreatment (BRAVE 3)
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Abciximab|OTHER: Placebo Heparin Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study Of PF-06700841, With Bioavailability/Food Effect Investigation
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: DRUG: PF-06700841 oral solution/suspension|OTHER: Placebo|DRUG: PF-06700841 tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Intravitreal Injection Versus Sub-Tenon's Infusion of Triamcinolone Acetonide for Refractory Diabetic Macular Edema During Cataract Surgery
Status: UNKNOWN
Conditions: Diabetic Macular Edema
Interventions: DRUG: Triamcinolone acetonide|DRUG: Triamcinolone acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Postural Insoles on Stability and Leg Muscular Activity
Status: COMPLETED
Conditions: Postural Stability|Muscular Activity
Interventions: DIAGNOSTIC_TEST: Postural stability assessment with a force platform.|DIAGNOSTIC_TEST: Muscular assessment with a electromyograph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BIBW 2992 (Afatinib) Versus Chemotherapy as First Line Treatment in NSCLC With EGFR Mutation
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Adenocarcinoma
Interventions: DRUG: Pemetrexed|DRUG: BIBW 2992|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation of Attention in Patients With MCI and Brain Subcortical Vascular Changes Using the APT-II
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Attention Process Training-II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiviral Therapy in Hepatitis B Virus (HBV)-Related Advanced Liver Disease Patients
Status: UNKNOWN
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Entecavir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Examine the Benefits of Fabric Made With Lyocell/Chitosan/Ceramide in the Treatment of Children With Mild to Moderate Eczema
Status: WITHDRAWN
Conditions: Atopic Dermatitis
Interventions: DEVICE: Non-medicated Emollient plus Lyocell/Chitosan Sleeve|OTHER: Non-medicated Emollient plus Cotton Sleeve|OTHER: Placebo Sleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Various Processed Oat Bran in a Beverage Matrix on Glycaemic Health
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Beverage powder with 12% oat bran processed with method A|OTHER: Beverage powder with 12% oat bran processed with method B|OTHER: Beverage powder with 12% oat bran processed with method C|OTHER: Placebo Comparator: Minimally-processed oat bran (Positive Control)|OTHER: Placebo Comparator: Readily-digestible carbohydrate (negative control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vırtual Reality Application ın Elderly People With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Person-centred Occupational Therapy Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Exercise and High-dose Salbutamol in Patients With Chronic Obstructive Pulmonary Disease (COPD) Receiving Therapeutic Doses of Indacaterol (QAB 149) and Salmeterol
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Indacaterol|DRUG: Placebo|DRUG: Salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gum Chewing on Sore Throat After Double-lumen Tube Intubation
Status: NOT_YET_RECRUITING
Conditions: Thoracic Surgery, Video-Assisted|Chewing Gum|Pharyngeal Diseases
Interventions: DIETARY_SUPPLEMENT: Chewing a piece of gum (Xylitol gum, LOTTE WELLFOOD, Korea) before induction of anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients
Status: ENROLLING_BY_INVITATION
Conditions: Breast Reconstruction|Radiation Dermatitis|Radiation Fibrosis|Fat Grafting
Interventions: PROCEDURE: Fat grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Intra-Oral Photobiomodulation on Orthodontic Treatment Time
Status: COMPLETED
Conditions: Malocclusion
Interventions: OTHER: Fixed Orthodontic Appliance Treatment|DEVICE: OrthoPulse™|DEVICE: Non-Functional OrthoPulse™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Caudal Epidural Steroid Injection Ultrasound Guided in LDP
Status: COMPLETED
Conditions: Refractory Lumbar Disc Prolapse
Interventions: DEVICE: ultrasound guided caudal epidural injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: etoposide|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: methylprednisolone|DRUG: mitoxantrone hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Electrical Stimulation in Patients With Idiopathic Pulmonary Fibrosis
Status: COMPLETED
Conditions: Idiopathic Pulmonary Fibrosis|Neuromuscular Electrical Stimulation
Interventions: OTHER: Aerobic exercise|OTHER: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on TIL for the Treatment of Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Tumor Infiltrating Lymphocytes|Treatment Side Effects|Effects of Immunotherapy
Interventions: BIOLOGICAL: GC203 TIL(gene-edited TIL) or autologous TILs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Trientine Plus Pegylated Liposomal Doxorubicin and Carboplatin in Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms Malignant (Excl Germ Cell)|Peritoneal Carcinoma|Fallopian Tube Cancer
Interventions: DRUG: trientine dihydrochloride|DRUG: pegylated liposomal doxorubicin|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise Intervention to Prevent Fall-related Fractures and Other Injuries : The Ossébo Study
Status: COMPLETED
Conditions: Accidental Falls|Fractures|Fall-related Injuries
Interventions: OTHER: Fall prevention exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD
Status: UNKNOWN
Conditions: Tourette's Syndrome|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: APO-clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Reactogenicity & Immunogenicity of an Influenza Pandemic Candidate Vaccine (GSK1562902A) in Primed Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Pandemic influenza candidate vaccine (GSK1562902A) - 1 dose|BIOLOGICAL: Pandemic influenza candidate vaccine (GSK1562902A) - 2 doses
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: d-cycloserine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Intradiscal Discogel® in Resistant Sciatica
Status: WITHDRAWN
Conditions: Herniated Disc|Sciatica|Persistent Pain, Leg
Interventions: DEVICE: Chemonucleolysis with Discogel|PROCEDURE: open discectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Herpetic Neuralgia
Status: COMPLETED
Conditions: Herpetic Neuralgia
Interventions: DRUG: HSK16149 20mg BID|DRUG: HSK16149 40mg BID|DRUG: Pregabalin 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ASHA Bangladesh--Integrated Intervention to Address Poverty and Depression
Status: RECRUITING
Conditions: Depression|Economic Vulnerability
Interventions: BEHAVIORAL: Manualized Group Based Psychotherapy|OTHER: Poverty Alleviation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nivolumab/Ipilimumab Plus Cabozantinib in Patients With Unresectable Advanced Melanoma
Status: SUSPENDED
Conditions: Melanoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: sublingual nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Ketamine for Methamphetamine Use Disorder
Status: NOT_YET_RECRUITING
Conditions: Substance Use Disorders|Substance Use|Methamphetamine Abuse
Interventions: DRUG: Ketamine Hydrochloride|DRUG: Midazolam Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Status: COMPLETED
Conditions: Cardiopulmonary Arrest|Cardiac Arrest
Interventions: DRUG: Vasopressin|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT to Compare Restrata and NPWT to Heal Complex DFUs
Status: WITHDRAWN
Conditions: Diabetic Wound
Interventions: DEVICE: Restrata|DEVICE: Negative Pressure Wound Therapy (NPWT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Gynecologic Cancer
Status: RECRUITING
Conditions: Ovarian Cancer|Cervix Cancer|Metastatic Cancer|Advanced Cancer|Gynecologic Cancer
Interventions: BIOLOGICAL: CD70 CAR-T cells|BIOLOGICAL: CD70 CAR-T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic ACL Brace: In Vivo Kinematics
Status: WITHDRAWN
Conditions: ACL Injury|ACL - Anterior Cruciate Ligament Rupture|ACL|ACL - Anterior Cruciate Ligament Deficiency
Interventions: DEVICE: Ossur Rebound ACL Brace
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prophylactic Cranial Irradiation Versus Observation in Stage IV NSCLC Randomized Controlled Clinical Study
Status: RECRUITING
Conditions: Prophylactic Cranial Irradiation, Cumulative Incidence of Brain Metastases
Interventions: RADIATION: Prophylactic Cranial Irradiation for experiment arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Fermented Tea Beverage Kombucha on the Oral and Gut Microflora
Status: COMPLETED
Conditions: Microbial Colonization
Interventions: OTHER: Consumption of kombucha|OTHER: Consumption of heat-sterilized kombucha
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Armodafinil|OTHER: Placebo|DRUG: Minocycline|BEHAVIORAL: Questionnaires
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ESKETamine for FIBromyalgia Treatment
Status: RECRUITING
Conditions: Fibromyalgia
Interventions: DRUG: Active comparator|DRUG: S-Ketamine Low dose|DRUG: S-Ketamine High dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safinamide for Levodopa-induced Dyskinesia (PD-LID)
Status: WITHDRAWN
Conditions: Dyskinesia, Drug-Induced|Parkinson Disease
Interventions: DRUG: Safinamide Methanesulfonate 150mg|DRUG: Safinamide Methanesulfonate 100mg|DRUG: Safinamide Methanesulfonate matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction
Status: NOT_YET_RECRUITING
Conditions: Caries|Gingivitis
Interventions: OTHER: Brushing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Clinical Features and Efficacy of Small Intestinal Bacterial Overgrowth in Patients With Abdominal Distension
Status: NOT_YET_RECRUITING
Conditions: Small Intestine Bacterial Overgrowth
Interventions: DRUG: Rifaximin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pulsed Field Ablation During Left Atrial Appendage Occlusion: A Randomised Controlled Trial
Status: WITHDRAWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: Catheter ablation of atrial fibrillation using Pulsed Field Ablation|DEVICE: Left atrial appendage occlusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficiency of Different Modes of Universal Adhesive
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries|Adhesion
Interventions: DEVICE: Self-etch|DEVICE: Total-etch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Stem Cell Transplantation for Multiple Myeloma and Myelofibrosis
Status: TERMINATED
Conditions: Anemia|ASXL1 Gene Mutation|EZH2 Gene Mutation|IDH1 Gene Mutation|IDH2 Gene Mutation|Plasma Cell Myeloma|Primary Myelofibrosis|Recurrent Plasma Cell Myeloma|Secondary Myelofibrosis|Thrombocytopenia
Interventions: DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine|PROCEDURE: Hematopoietic Cell Transplantation|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Multi-site, Randomized, Sham-Controlled, Double-Blind Trial With One-Way Crossover Designed to Assess the Effectiveness and Safety of the Gimer NeuroBlock SCS Trialing System for the Treatment of Chronic Back Pain and/or Lower Limb Pain
Status: COMPLETED
Conditions: Chronic Pain|Low Back Pain|Lower Limb Pain
Interventions: DEVICE: NeuroBlock UHF stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
Status: RECRUITING
Conditions: Eye Diseases|Macular Degeneration, Wet|Sub-Macular Hemorrhage
Interventions: PROCEDURE: Pars plana vitrectomy|DRUG: Intravitreal 2 mg aflibercept (Eylea, Bayer) will be injected at baseline then monthly for two further doses, then 2-monthly until month 12|DRUG: subretinal injection of recombinant TPA (Alteplase) up to a maximum of 25 micrograms in 0.2 mls|DRUG: Intravitreal 20% sulfahexafluoride (SF6) gas tamponade
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scopolamine Patch Pharmacokinetics in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Transderm Scop®|DRUG: Intravenous scopolamine hydrobromide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: High Dose Candesartan Versus Quinapril for Restenosis Prophylaxis After Stent Angioplasty
Status: COMPLETED
Conditions: Arterial Occlusive Diseases
Interventions: DRUG: candesartan (drug) or quinapril (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Impact of Increased Immunoglobulin E to Anti-herpes Simplex Virus -1 Innate Immune Responses in Atopic Dermatitis Patients With Eczema Herpeticum
Status: UNKNOWN
Conditions: Atopic Dermatitis With a History of Eczema Herpeticum|Atopic Dermatitis Without a History of Eczema Herpeticum|Health Controls Without Atopy
Interventions: BIOLOGICAL: Xolair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety Study of Combination of Hormone Therapy, Paclitaxel and Radiation Therapy to Treat Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Hormone Suppressors|DRUG: Paclitaxel|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infection
Status: RECRUITING
Conditions: Infection Due to Carbapenem Resistant Acinetobacter
Interventions: DRUG: Colistin Sodium Methanesulfonate|DRUG: Colistin Sodium Methanesulfonate plus Fosfomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Mechanical Stimulation on Mastectomy Scars
Status: COMPLETED
Conditions: Breast Cancer
Interventions: OTHER: Mechanical stimulation (LPG system; Cellu M6 Integral I)|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 10 Years Evaluation of Composite Restoration
Status: COMPLETED
Conditions: Dental Restoration, Permanent
Interventions: DEVICE: Astralis 10 HPM|DEVICE: Astralis 10 RM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Preemptive Treatment With Grazoprevir and Elbasvir for Donor HCV Positive to Recipient HCV Negative Kidney Transplant
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: elbasvir (50mg) / grazoprevir (100mg) (fixed dose combination)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION