pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Role of Lung Ultrasound Imaging in the Comparison of Two Mechanical Ventilation Strategies During Laparotomy
Status: COMPLETED
Conditions: Atelectasis
Interventions: OTHER: PEEP and recruitment maneuvers|OTHER: ZEEP (no PEEP nor recruitment maneuver)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: UCon Treatment of the Symptoms of Faecal Incontinence (FI)
Status: RECRUITING
Conditions: Faecal Incontinence|Faecal Incontinence With Faecal Urgency
Interventions: DEVICE: UCon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-Cell Response in Patients Receiving Trastuzumab and/or Chemotherapy for HER2-Positive Solid Tumors
Status: COMPLETED
Conditions: Breast Cancer|Lung Cancer|Ovarian Cancer|Prostate Cancer|Sarcoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study in Participants With Chronic Hepatitis B (CHB) Receiving Therapy With Peginterferon Alfa-2a 40 Kilodaltons (kD) (PEGASYS) - The PRO B Study
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: Peginterferon alfa-2a
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multivirus-specific T-cell Transfer Post SCT vs AdV, CMV and EBV Infections
Status: RECRUITING
Conditions: AdV Infection|EBV Infection|CMV Infection|Stem Cell Transplant Complications
Interventions: OTHER: Multivirus (CMV, EBV, AdV)-specific T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension.
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Selexipag|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Revlimid And Prednisone Followed By Revlimid, Melphalan And Prednisone In Multiple Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: RP followed by MPR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Israeli 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1/2 Emphysema Study - Initial Formulation
Status: TERMINATED
Conditions: Pulmonary Emphysema
Interventions: BIOLOGICAL: BLVR Hydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rhinogenic Headache Improvement After Nasal Operation
Status: TERMINATED
Conditions: Headache
Interventions: PROCEDURE: Septoplasty|PROCEDURE: Septoplasty and endoscopic contact point correction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Power of Peanuts School Feeding
Status: COMPLETED
Conditions: School Feeding Programs|Nutrition Supplements
Interventions: DIETARY_SUPPLEMENT: Standard meal|DIETARY_SUPPLEMENT: School food ready-to-use|DIETARY_SUPPLEMENT: School food ready-to-use plus Milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies
Status: COMPLETED
Conditions: Chronic Myelogenous Leukemia|Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)|Hypereosinophilic Syndrome|Systemic Mastocytosis
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Creatine in Preventing Muscle Aching From Cholesterol-Lowering Statin Drugs
Status: COMPLETED
Conditions: Hypercholesterolemia|Aches|Cramps|Weakness
Interventions: DIETARY_SUPPLEMENT: Creatine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Multiple-Dose, Open-Label, Phase 1, Pharmacokinetic, Pharmacodynamic, and Safety Study of Avonex® in Chinese Healthy Volunteer Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Avonex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of the dermaPACE® (Pulsed Acoustic Cellular Expression) Device in Conjunction With Standard of Care Versus Standard of Care Alone in the Treatment of Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcers
Interventions: DEVICE: Electrohydraulic-generated shock wave|DEVICE: Sham device plus standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: EEG Monitoring to Assess Emergence From Neuroanesthesia
Status: COMPLETED
Conditions: Cerebral Aneurysm|Trigeminal Neuralgia
Interventions: DEVICE: On-line EEG monitoring during neurosurgery|DEVICE: EEGo vs BIS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.
Status: COMPLETED
Conditions: Angina, Unstable|Cardiovascular Diseases|Heart Diseases|Coronary Disease|Myocardial Infarction|Heart Failure, Congestive
Interventions: DRUG: GIK|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Blinded, Cross-sectional, Diagnostic Evaluation Study Performed in Pulmonary TB Suspects at the TB Dispensary for Sector 4 of the Marius-Nasta-Institute in Bucharest, Romania
Status: COMPLETED
Conditions: Tuberculosis
Interventions: OTHER: Observational
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Carboplatin and Paclitaxel With or Without ISIS 3521 in Treating Patients With Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: BIOLOGICAL: ISIS 3521|DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Dyadic Intervention for Young Adult Patients With Cancer and Their Partner Caregivers
Status: RECRUITING
Conditions: Cancer|Survivorship|Caregiver Burden|Psychological Distress|Coping Skills|Couples
Interventions: BEHAVIORAL: Young Adults Coping with Cancer Together Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Percutaneous Intradiscal Radiofrequency as A Treatment for Radicular Pain From Lumbar Disc Herniation
Status: RECRUITING
Conditions: Disk Herniated Lumbar|Radicular Pain|Intradiscal Radiofrequency
Interventions: DEVICE: Percutaneous intradiscal radiofrequency treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CREATION: A Clinical Trial of Qigong for Neuropathic Pain Relief in Adults With Spinal Cord Injury
Status: RECRUITING
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Qigong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fascial Distortion Model With And Without Neck Isometrics In Patients With Cervical Spine Overload
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: FDM with isometrics|OTHER: FDM without isometrics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of D-4517.2 After Subcutaneous Administration in Healthy Participants
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration|Diabetic Macular Edema
Interventions: DRUG: D-4517.2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis
Interventions: DRUG: BMS-986158|DRUG: Ruxolitinib|DRUG: Fedratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Dihydroartemisinin/Piperaquine (Artekin®) for the Treatment of Uncomplicated Malaria in Peru
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Dihydroartemisin-piperaquine|DRUG: Mefloquine + Artesunate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of a Pulsed Field Device for Global Mapping and Ablation of the Left Atrium for the Treatment of Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: Globe Mapping and Pulsed Field Ablation System (Globe PF System)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Enteral Anastomosis for the Treatment of Gastric Outlet Obstruction: A Randomized Controlled Study Comparing Endoscopic Versus Surgical Gastrojejunostomy
Status: RECRUITING
Conditions: Gastric Outlet Obstruction
Interventions: PROCEDURE: Surgical gastrojejunostomy (SGJ)|PROCEDURE: Endoscopic gastrojejunostomy (EGJ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Capsaicin Topical Solution|OTHER: Drug product vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Pharmacokinetics and Safety of AZD9977 in Participants With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: AZD9977
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, Tolerability & Efficacy of Certican in de Novo Heart Transplant (Tx) Patients
Status: COMPLETED
Conditions: Heart Transplantation
Interventions: DRUG: Everolimus (Certican)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study)
Status: COMPLETED
Conditions: Emphysema
Interventions: DEVICE: Lung Volume Reduction Coil (LVRC) (PneumRx)|DEVICE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of DW340 in Patients With Acute Low Back Pain
Status: COMPLETED
Conditions: Acute Low Back Pain
Interventions: DRUG: DW340(pelubiprofen/eperisone)|DRUG: Pelubi(pelubiprofen)|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Identification and Characterization of Bacteria in the Lungs of Children From 6 Months up to 6 Years Old, With Suspected Infection of the Lungs, in Spain.
Status: COMPLETED
Conditions: Infections, Streptococcal
Interventions: OTHER: BAL fluid sampling|OTHER: Nasopharyngeal swab sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ultrasound-guided Peripheral Vascular Access: What Approaches in Paediatrics?
Status: COMPLETED
Conditions: Pediatric Anesthesia|Comparison of 3 Peripheral Vascular Access
Interventions: OTHER: Ultrasound-guided approach to peripheral vascular access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Investigation of Single Ascending Doses of NNC9204-1706 in Male Subjects Being Overweight or With Obesity
Status: COMPLETED
Conditions: Metabolism and Nutrition Disorder|Obesity
Interventions: DRUG: NNC9204-1706 A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lexapro and Pramipexole and to Treat Major Depression
Status: COMPLETED
Conditions: Major Depression
Interventions: DRUG: Pramipexole|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Glycemic Stability of Insulin Aspart Versus Insulin Lispro in Insulin Pump Therapy
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Insulin Aspart versus Insulin Lispro|DRUG: Insulin Lispro versus Insulin Aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Status: COMPLETED
Conditions: Subclinical Hypothyroidism
Interventions: DRUG: Levothyroxine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tirofiban Plus Intravenous Thrombolysis in Acute Anterior Choroidal Infarction or Paramedian Pontine Infarction
Status: COMPLETED
Conditions: Acute Anterior Choroidal Infarction (ACI)|Paramedian Pontine Infarction (IPP)
Interventions: PROCEDURE: IVT with tenecteplase or alteplase|PROCEDURE: Intervention Name : Tirofiban and IVT with tenecteplase or alteplase
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Investigating Immune Responses to Aerosol BCG Challenge in Healthy UK Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Tuberculosis
Interventions: BIOLOGICAL: BCG Danish|OTHER: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Testing Olaparib in Patients With Advanced or Metastatic (Cancer That Has Spread) Bladder Cancer and Other Genitourinary Tumors With DNA-Repair Genetic Changes
Status: RECRUITING
Conditions: Advanced Bladder Carcinoma|Advanced Genitourinary System Carcinoma|Metastatic Bladder Carcinoma|Metastatic Genitourinary System Carcinoma|Stage III Bladder Cancer AJCC v8|Stage IV Bladder Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Biopsy|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|DRUG: Olaparib|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Amikacin in Preventing AECOPD
Status: UNKNOWN
Conditions: COPD|COPD Exacerbation
Interventions: DRUG: aerosol inhaled Amikacin Sulfate Injection|OTHER: conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Intraosseous Versus Intravenous Vascular Access During Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest
Interventions: DEVICE: Intravenous access during OHCA|DEVICE: Humeral IO insertion|DEVICE: TIbial IO insertion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proellex Pharmacokinetics Bridging Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: 25 mg Proellex|DRUG: 25 mg Proellex|DRUG: 25 mg Proellex|DRUG: 50 mg Proellex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate Neurocognitive Injury and Longitudinal Changes in White Matter During Radiation Therapy in Children With Primary Brain Tumors
Status: TERMINATED
Conditions: Brain Tumor, Primary
Interventions: RADIATION: Cranial Radiotherapy|DEVICE: MRI with Diffusion Tensor Imaging (DTI)|BEHAVIORAL: Neuro-cognitive Testing (CogState)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Placebo|DRUG: Sotatercept|OTHER: SOC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Predictors of Difficult Laparoscopic Cholecystectomy, Scoring Systems and Their Implications on the Outcomes , Sohag Experience.
Status: RECRUITING
Conditions: Chronic Calculous Cholecystitis
Interventions: PROCEDURE: laparoscopic cholecystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Neocartilage Implant to Treat Cartilage Lesions of the Knee
Status: TERMINATED
Conditions: Articular Cartilage Disorder|Degeneration; Articular Cartilage|Chronic Cartilage Injury|Acute Cartilage Injury|Defect of Articular Cartilage
Interventions: BIOLOGICAL: Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft)|OTHER: Microfracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of E2007 to Treat Partial and Generalised Seizures in People With Epilepsy
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: E2007|DRUG: E2007|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CONCERTA (OROS Methylphenidate Hydrochloride) for the Treatment of Attention Deficit Hyperactivity Disorder in Adults
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: CONCERTA (OROS methylphenidate hydrochloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reconstruction of a Neurocutaneous Defect of the Proximal Phalanx With a Heterodigital Arterialized Nerve Pedicle Flap
Status: COMPLETED
Conditions: Complex Digital Injuries
Interventions: PROCEDURE: Composite Flap
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Spontaneous Dental Abscesses in Children With X-linked Hypophosphatemia : a RCT
Status: NOT_YET_RECRUITING
Conditions: X-linked Hypophosphatemia (XLH)
Interventions: DEVICE: adhesive system|DEVICE: fluoride varnish|DRUG: flowable composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Studying Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia Previously Enrolled on Clinical Trial POG-9421
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: proteomic profiling|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MIcroorganisms as Triggers in Acute Severe Ulcerative Colitis and Their Influence on Medical Therapy Efficacy: a Multi-omics Pilot Approach.
Status: UNKNOWN
Conditions: Inflammatory Bowel Diseases|Colitis|Ulcerative
Interventions: BIOLOGICAL: Blood samples|PROCEDURE: Stool samples|PROCEDURE: Colorectal biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Health Benefits of Tart Cherry in Ulcerative Colitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Montmorency tart cherry|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Early Feasibility Study of UV-Femtosecond Laser Assisted Lenticular Extraction
Status: COMPLETED
Conditions: Refractive Error - Myopia Severe|Refractive Error - Myopia Simple
Interventions: DEVICE: WaveLight® Ultraviolet Femtosecond (FS) Laser System|PROCEDURE: Laser Assisted Lenticular Extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors
Status: COMPLETED
Conditions: Astrocytoma|Glioma|Oligodendroglioma
Interventions: BIOLOGICAL: Hepatitis A Vaccine|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Tetanus Toxoid Vaccine|BIOLOGICAL: Trivalent Influenza Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial Investigating the Relationship Between Pharmacodynamic and Interstitial Concentration for Insulin Detemir and Human Insulin
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: insulin detemir|DRUG: human soluble insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolisation Plus Bevacizumab for Treatment of Hepatocellular Carcinoma
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART)
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Tomivosertib|BIOLOGICAL: Pembrolizumab|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Addition of Fulvestrant to Erlotinib in Stage IIIB/IV Non-Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non Small Cell Lung Carcinoma
Interventions: DRUG: Fulvestrant and Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: mHACMb|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Fluzopril Combined With Apatinib in Maintenance Treatment of Platinum Resistant Recurrent Ovarian Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Ovarian Cancer Recurrent
Interventions: DRUG: Fluzopril Combined With Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis|Pain, Joint|Stiffness of Knee, Not Elsewhere Classified|Quality of Life
Interventions: DRUG: Sodium Hyaluronate|DRUG: Normal Saline|DRUG: Triamcinolone Acetonide 10mg/mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isatuximab Plus Pomalidomide and Dexamethasone Association for Patients With AL Amyloidosis Not in VGPR or Better After Any Previous Therapy
Status: RECRUITING
Conditions: AL Amyloidosis
Interventions: DRUG: Isatuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Decolonization and Surgical Site Infections in Orthopaedic Surgery - 2 Year Outcome in Prosthetic Surgery
Status: COMPLETED
Conditions: Staphylococcus Aureus|Orthopaedic Surgery|Surgical Site Infection|Prevention
Interventions: DRUG: Chlorhexidine, Lifo-Scrub sol 4%®, 500ml, B. Braun|DRUG: BACTROBAN® Nasal ong
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Brain Radiotherapy in Patients With Asymptomatic Brain Metastasis in the Era of Targeted Therapy for NSCLC
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer|Brain Metastases
Interventions: DRUG: molecular targeted therapies|RADIATION: Brain Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adjuvant & Route of Administration on Safety & Immunogenicity of NDV-3 Vaccine
Status: COMPLETED
Conditions: Staphylococcal Infections|Yeast Infections|Candidiasis
Interventions: BIOLOGICAL: NDV-3 vaccine with alum IM|BIOLOGICAL: NDV-3 vaccine without alum IM|BIOLOGICAL: Placebo with alum IM|BIOLOGICAL: NDV-3 vaccine without alum ID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: To Assess the Effect of Administration of 2 Formulation of AZD3241 on Blood Concentration in Healthy Volunteers
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: AZD3241 ER formulation 1|DRUG: Placebo|DRUG: AZD3241 Alternative titration scheme with formulation 1 or 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study of a PD-1/CTLA-4 Bispecific Antibody AK104 in Patients With Metastatic Nasopharyngeal Carcinoma
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: BIOLOGICAL: AK104
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Overlap and End-to-end Repair in Anal Sphincter Rupture During Delivery
Status: COMPLETED
Conditions: Rupture|Childbirth
Interventions: PROCEDURE: End-to-end repair of the external anal sphincter muscle|PROCEDURE: Overlap repair of the external anal sphincter muscle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pregnancy and Contraception Education in Chronic Kidney Disease (PACE-CKD)
Status: RECRUITING
Conditions: CKD|Chronic Kidney Diseases
Interventions: BEHAVIORAL: Decision aid|OTHER: Standard handout
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Phase II Study of CP-4055 as Second Line Therapy in Patients With Advanced Colorectal Cancer
Status: COMPLETED
Conditions: Advanced Colorectal Cancer|Colorectal Cancer
Interventions: DRUG: CP-4055
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use Fentanyl
Status: RECRUITING
Conditions: Opioid Use Disorder
Interventions: DRUG: Naloxone Nasal Spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Protective Effects of RIC in Elderly With Acute Ischemic Stroke Complicating Acute Coronary Syndrome
Status: COMPLETED
Conditions: Elderly Patients|Acute Ischemic Stroke|Acute Coronary Syndrome
Interventions: DEVICE: RIC|DEVICE: sham-RIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate Effects of Omega-3 Carboxylic Acids and Dapagliflozin on Liver Fat Content in Diabetic Patients
Status: COMPLETED
Conditions: T2 Diabetes and Fatty Liver Disease (Non-alcoholic Origin)
Interventions: DRUG: placebo|DRUG: Omega-3 carboxylic acids|DRUG: Dapagliflozin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Intelligent Biometrics for PTSD - Clinical Trial
Status: COMPLETED
Conditions: PTSD
Interventions: DEVICE: Therapist Guided Prolonged Exposure with BioWare Device|DEVICE: Record Only Prolonged Exposure with BioWare Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lopinavir/r Monotherapy Versus Abacavir/Lamivudine and Lopinavir/r for Limb Fat Recovery in Persons With Lipoatrophy
Status: COMPLETED
Conditions: HIV Infection|Lipodystrophy|HIV Infections
Interventions: DRUG: Monotherapy (Lopinavir/ritonavir)|DRUG: Monotherapy (Lopinavir/ritonavir) + ABC/3TC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Azithromycin for COVID-19 Treatment in Outpatients Nationwide
Status: TERMINATED
Conditions: COVID-19|SARS-CoV-2
Interventions: DRUG: Azithromycin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Pharmacology of MDA [3,4-methylenedioxyamphetamine]
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: MDA|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase I/II Study of the Photon Radiosurgery System
Status: COMPLETED
Conditions: Brain Tumor, Recurrent|Glioblastoma Multiforme
Interventions: PROCEDURE: Photon Radiosurgery System (Intrabeam)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Acceptability and Effectiveness of the SOmNI Mobile Phone App for Sleep Promotion in Adolescents
Status: COMPLETED
Conditions: Sleep Deprivation
Interventions: DEVICE: SOmNI app|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Durvalumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Paclitaxel Coated PTCA Balloon Catheter With a Shellac Plus Vitamin E Excipient (GENOSS® DCB) in Patients With Coronary In-stent Restenosis (ISR): A Prospective, Multi-center, Observational Study
Status: RECRUITING
Conditions: Coronary Artery Disease|In-stent Restenosis
Interventions: DEVICE: Genoss® DCB
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impacts of Public Announcements of Goals and Outcomes on Goal Completion (Commit to Steps)
Status: COMPLETED
Conditions: Behavior and Behavior Mechanisms
Interventions: BEHAVIORAL: Precommitment announcement|BEHAVIORAL: Results announcement|BEHAVIORAL: Walking program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream
Status: COMPLETED
Conditions: Sunscreening Agents
Interventions: OTHER: Physiogel Daily Defence Protective Day Cream Light|OTHER: ISO 24444:2010 P3 Standard Sunscreen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: TDS-943 (topical diclofenac sodium 4% spray)|DRUG: celecoxib|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of PM8002 Injection in Combination With Standard Chemotherapy as First Line Therapy in MPM
Status: RECRUITING
Conditions: MPM
Interventions: DRUG: PM8002|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Immunogenicity of TETRALITE, a Novel Adjuvanted, Low-dose Influenza Vaccin
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: TETRALITE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Vonoprazan in Eradication of Resistant Strain of Helicobacter Pylori
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Vonoprazan, Amoxicillin and Levofloxacin|DRUG: Pantoprazole 40mg, Amoxicillin and Levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Normobaric Oxygen (NBO) Therapy in Acute Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: BIOLOGICAL: Oxygen|BIOLOGICAL: Room air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Cluster-randomised Trial of Interventions to Improve Antimalarial Prescribing With Malaria Tests
Status: COMPLETED
Conditions: Malaria
Interventions: BEHAVIORAL: Control|BEHAVIORAL: HW|BEHAVIORAL: HWC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)
Status: RECRUITING
Conditions: Iron-deficiency|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Ferric Derisomaltose 1000 Mg in 100 mL INTRAVENOUS SOLUTION [Monoferric]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
Status: RECRUITING
Conditions: Cardiovascular Diseases|End Stage Renal Disease|Kidney Transplantation|Dialysis Related Complication
Interventions: OTHER: No screening|OTHER: Regular Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: 3-Month Home-based Training With Whole Body Vibration (WBV) Device in Patients With Heart Failure and Preserved Ejection Fraction (GALILEO-HFpEF-HOME) (GALILEOHOME)
Status: UNKNOWN
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DEVICE: Group 1 GALILEO WBV|OTHER: Group 2 Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy, Safety and Tolerability of CBL-514 Injection for Reducing Abdominal Subcutaneous Fat
Status: COMPLETED
Conditions: Subcutaneous Fat
Interventions: DRUG: CBL-514 Injection|OTHER: 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses
Status: RECRUITING
Conditions: Breast Carcinoma
Interventions: PROCEDURE: Contrast-Enhanced Ultrasound|DRUG: Perflutren Lipid Microspheres|DRUG: Sulfur Hexafluoride Lipid Microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Telemedically Assisted Sampling of COVID-19 Patients - Is the Sampling Quality Sufficient
Status: ACTIVE_NOT_RECRUITING
Conditions: Telemedicine|Pharynx|COVID-19
Interventions: DIAGNOSTIC_TEST: telemedically guided oropharyngeal + nasal (OP+N) self-sampling (GSS) and nasopharyngeal (NP) or OP+N sampling performed by health care professionals (HCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate BBI-001 in Hereditary Haemochromatosis (HH) Patients and Iron Deficient Volunteers
Status: TERMINATED
Conditions: Hereditary Hemochromatosis
Interventions: DRUG: BBI-001|DIETARY_SUPPLEMENT: Original Fibre Metamucil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study of ASP1585 in Chronic Kidney Disease Patients With Hyperphosphatemia on Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease|Renal Dialysis|Renal Insufficiency
Interventions: DRUG: ASP1585|DRUG: Sevelamer hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effect of Lurbinectedin (PM01183) on Cardiac Repolarization in Patients With Selected Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: lurbinectedin (PM01183)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Immersive Virtual Reality Treatment With Cognitive Behaviour Therapy for Obsessive-Compulsive Disorder
Status: NOT_YET_RECRUITING
Conditions: Obsessive-Compulsive Disorder|Virtual Reality
Interventions: COMBINATION_PRODUCT: The combination of exposure and response prevention (ERP) and VR|BEHAVIORAL: Traditional ERP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety And Immunogenicity Study Of A 13-valent Pneumococcal Conjugate Vaccine In Japanese Subjects Aged 6 To 64 Years.
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Hyperbaric Prilocaine 2% 50 Mg and Hyperbaric Bupivacaine 0.5% 12.5 Mg Against Spinal Anesthesia Recovery Time in Cystoscopy Procedure
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia|Anesthesia; Reaction
Interventions: DRUG: Prilocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does What You Eat Affect Your Brain
Status: RECRUITING
Conditions: Gliosis|Obesity|Eating
Interventions: OTHER: Diet modification #1|OTHER: Diet modification #2|OTHER: Diet modification #3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Evaluate the Safety and Pharmacokinetics of SPI-1005
Status: COMPLETED
Conditions: Hearing Loss|Cancer
Interventions: DRUG: SPI-1005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Addressing COVID-19 Mental Health Problems Among US Veterans
Status: COMPLETED
Conditions: Brief Video-based Intervention|Vignette Based Intervention|Non Intervention Control Arm
Interventions: OTHER: A short video intervention|OTHER: A vignette intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Xyotax (CT-2103) in Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: CT-2103 (Xyotax)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Timing of Low Vision Rehabilitation in Anti- Vascular Endothelial Growth Factor (VEGF) Therapy
Status: COMPLETED
Conditions: Low Vision|Neovascular Age-related Macular Degeneration
Interventions: OTHER: Vision rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Continuous and Pulsed Oral Doxycycline Treatment Protocols for Refractory Meibomian Gland Dysfunction
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction|Blepharitis|Doxycycline Adverse Reaction
Interventions: DRUG: Doxycyclin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of LY3305677 Compared With Placebo in Adult Participants With Obesity or Overweight
Status: RECRUITING
Conditions: Obesity|Overweight and Obesity
Interventions: DRUG: LY3305677|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: LCB84|DRUG: Anti-PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Bright Light Therapy for Patients With Depression
Status: UNKNOWN
Conditions: Depressive Disorder|Light Therapy
Interventions: DEVICE: adjunctive bright white light therapy in the morning|DEVICE: adjunctive bright white light therapy in the afternoon|DEVICE: adjunctive dim red light therapy in the afternoon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Atezo, Adjuvant Atezo + Beva Combined With RF Ablation of Small HCC: a Multicenter Randomized Phase II Trial
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab (neoadjuvant)|PROCEDURE: Percutaneous Radiofrequency|DRUG: Bevacizumab (adjuvant)|DRUG: Atezolizumab (adjuvant)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Ivermectin in Subjects Infected With SARS-CoV-2 With or Without Symptoms
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Ivermectin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bevacizumab and Modified FOLFOX-6 (mFOLFOX-6) in Participants With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: 5-Fluorouracil (5-FU)|DRUG: Bevacizumab|DRUG: Levofolinic acid|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of S-1 Plus Irinotecan and Oxaliplatin in Advanced Gastrointestinal Malignancy
Status: UNKNOWN
Conditions: Colorectal Neoplasm|Gastric Neoplasm|Secondary
Interventions: DRUG: S-1, Irinotecan, Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Docosahexaenoic Acid (DHA) on Heart Rate Variability in Elderly Patients
Status: COMPLETED
Conditions: Arrhythmia
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid (DHA)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION