pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Comparison of Volumetric Laser Endomicroscopy (VLE) and Endoscopic Mucosal Resection (EMR) in Patients With Barrett's Dysplasia or Intramucosal Adenocarcinoma
Status: COMPLETED
Conditions: Barrett'S-associated Dysplasia|Intramucosal Adenocarcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Esophagus Squamous Cell Carcinoma|Squamous Cell Carcinoma of the Head and Neck|Anal Canal Squamous Cell Carcinoma|Metastatic Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Autologous Ex-vivo Gene Modified HSCT in MPSII
Status: RECRUITING
Conditions: Mucopolysaccharidosis II
Interventions: GENETIC: Autologous CD34+ HSCs transduced ex vivo with CD11B LV encoding human IDS tagged with ApoEII
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Versus Multiple Fractionated SSRS for Spinal Metastases
Status: UNKNOWN
Conditions: Secondary Malignant Neoplasm of Spine
Interventions: RADIATION: SF-SSRS|RADIATION: MF-SSRS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BMI-based Vitamins in Obese Pregnant Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: BMI-based prenatal vitamin|DIETARY_SUPPLEMENT: Standard prenatal vitamin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tomato Consumption and High Density Lipoprotein-cholesterol
Status: COMPLETED
Conditions: Hypoalphalipoproteinemia
Interventions: DIETARY_SUPPLEMENT: Tomato consumption|DIETARY_SUPPLEMENT: Cucumber consumption
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rhu-pGSN to Mitigate Proinflammatory Responses to Decompression in Healthy SCUBA Divers
Status: NOT_YET_RECRUITING
Conditions: Decompression Sickness
Interventions: DRUG: Sodium Chloride 0.9% Inj pre-exposure|DRUG: Sodium Chloride 0.9% Inj post-exposure|DRUG: Recombinant human plasma gelsolin pre-exposure|DRUG: Recombinant human plasma gelsolin post-exposure|OTHER: Hyperbaric chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate the Efficacy and Safety of Suganon Tab. or Sugamet XR Tab.
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Evogliptin|DRUG: Evogliptin|DRUG: Metformin and Evogliptin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IPACK and Adductor Canal Catheter Patient Outcomes for TKAs?
Status: COMPLETED
Conditions: Surgery|Acute Pain
Interventions: PROCEDURE: Adductor Canal Block + Catheter & IPACK block|PROCEDURE: Adductor canal block + catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minocycline In Neurocognitive Outcomes - Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease|Cognitive Impairment|Cognitive Decline|Cognitive Change|Cognitive Dysfunction|Cognitive Deficit|Neuroinflammatory Response
Interventions: DRUG: Minocycline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation for the Treatment of Poorly Controlled Partial Epilepsy
Status: COMPLETED
Conditions: Partial Epilepsy|Seizures
Interventions: DEVICE: Cadwell High-Speed Magnetoelectric Stimulator|DEVICE: Magpro High-Speed Magnetoelectric Stimulator
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Image Guided Treatment Optimization With Cetuximab for Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Dose escalation cetuximab|DRUG: Standard dose cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Impact of Patient Photographs for Preventing Wrong-Patient Errors
Status: UNKNOWN
Conditions: Medical Errors|Electronic Medical Records
Interventions: BEHAVIORAL: Photo in Verification Alert|BEHAVIORAL: Photo in Banner|BEHAVIORAL: Photo in Banner and Verification Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of an Accelerated Body-whole Bone CT Procedure With the CZT "VERITON-CT ™" Camera
Status: UNKNOWN
Conditions: Bone Metastases
Interventions: DIAGNOSTIC_TEST: to record a whole body 3D of 25 minutes in camera VERITON-CT ™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: ASP-1929 Photoimmunotherapy (PIT) Study in Patients With Recurrent Head/Neck Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma of Head and Neck
Interventions: COMBINATION_PRODUCT: ASP-1929 Photoimmunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging and Biomarkers of Atherosclerosis in Patients With Stable or Unstable Coronary Artery Disease
Status: COMPLETED
Conditions: Atherosclerosis|Coronary Artery Disease|Acute Coronary Syndrome
Interventions: DEVICE: Coronary intervention using IVUS-VH & FDG PET-MDCT|DEVICE: Coronary intervention using IVUS-VH & FDG PET-MDCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple Sclerosis
Status: COMPLETED
Conditions: Spasticity in Participants With Multiple Sclerosis
Interventions: DRUG: Nabiximols|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Robot BABA Approach and Chest Breast Approach for Lateral Neck Dissection
Status: UNKNOWN
Conditions: Thyroid Carcinoma|Robot Surgery|Endoscopic Surgery
Interventions: DEVICE: Robot|DEVICE: Total endoscopic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PST for Care Partners of Adults With Alzheimer's and Alzheimer'S-related Dementia
Status: COMPLETED
Conditions: Alzheimer Disease|Frontotemporal Degeneration (FTD)|Lewy Body Dementia (LBD)|Vascular Contributions to Cognitive Impairment and Dementia (VCID)|Mixed Etiology Dementias (MED)|Mild Cognitive Impairment (MCI)
Interventions: BEHAVIORAL: Problem Solving Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Chronic Hepatitis C With PegIntron as Monotherapy or in Combination With Ribavirin (Study P04437)(COMPLETED)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepacivirus
Interventions: BIOLOGICAL: Peginterferon alfa-2b (SCH 54031)|DRUG: Ribavirin (SCH 18908)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma Recurrent
Interventions: DRUG: Isatuximab IV|DRUG: Isatuximab SC|DRUG: Dexamethasone|DRUG: Pomalidomide|DRUG: Dexamethasone|DRUG: Montelukast|DRUG: Paracetamol / Acetaminophen|DRUG: Diphenhydramine|DRUG: Methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Insulin Treatment in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Insulin or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mitral Doppler as a Predictor of Respiratory Worsening After Vascular Filling
Status: UNKNOWN
Conditions: Respiration, Artificial|Vascular Filling|Echocardiography
Interventions: DIAGNOSTIC_TEST: mitral doppler
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Immunogenicity and Safety of Tri Fluvac, a Seasonal Trivalent Inactivated Influenza Vaccine in Healthy Thai Adults
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GPO Tri Fluvac vaccine|BIOLOGICAL: Licensed influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.
Status: RECRUITING
Conditions: Myelodysplastic Syndromes|Leukemia, Myelomonocytic, Chronic
Interventions: DRUG: decitabine|DRUG: spartalizumab|DRUG: sabatolimab|DRUG: azacitidine|DRUG: venetoclax|DRUG: INQOVI (oral decitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fetal Ovarian Cyst Aspiration to Prevent Torsion
Status: COMPLETED
Conditions: Ovarian Cyst|Ultrasonography Prenatal
Interventions: PROCEDURE: Fetal ovarian cyst aspiration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of WX390 Combined With Toripalimab in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: WX390|DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation Combined With Exercise in Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain|Transcranial Direct Current Stimulation
Interventions: DEVICE: Transcranial direct current stimulation|DEVICE: Sham Transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study, Non Inferiority Between Noex® 32µg Versus Budecort Aqua® 32µg in Treatment of Alergic Rhinitis
Status: WITHDRAWN
Conditions: Rhinitis, Allergic, Perennial
Interventions: DRUG: Budesonide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: MechSens - Dose-response Relationship of in Vivo Ambulatory Load and Mechanosensitive Cartilage Biomarkers
Status: ACTIVE_NOT_RECRUITING
Conditions: Articular Cartilage Degeneration
Interventions: PROCEDURE: walking stress test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Ginsenoside Rg3 in Combination With First-line Chemotherapy in Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Self Efficacy
Interventions: DRUG: Ginsenoside Rg3 plus First-line Chemotherapy|DRUG: First-line Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adjunctive Isradipine for the Treatment of Bipolar Depression
Status: TERMINATED
Conditions: Bipolar Disorder
Interventions: DRUG: Isradipine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Different Schedules of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Healthy Participants
Status: COMPLETED
Conditions: Dengue Fever
Interventions: BIOLOGICAL: Takeda's Tetravalent Dengue Vaccine Candidate (TDV)|BIOLOGICAL: TDV Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Carbohydrate Mouth-rinse
Status: UNKNOWN
Conditions: Carbohydrate Mouth-rinse on Time Trial Performance
Interventions: DIETARY_SUPPLEMENT: Carbohydrate drink|DIETARY_SUPPLEMENT: Placebo mouth rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone Surgery
Status: UNKNOWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: cisplatin|DRUG: lomustine|DRUG: vincristine sulfate|PROCEDURE: adjuvant therapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Assess the Pharmacodynamics of Oral AR-C165395XX in Subjects With Type 2 Diabetes Mellitus (T2DM)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: AR-C165395XX|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: [Ac-225]-PSMA-62 Trial in Biochemically Recurrent and Metastatic Castration Resistant Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer|Metastatic Castration-resistant Prostate Cancer|Biochemically Recurrent Prostate Carcinoma
Interventions: DRUG: [Ac-225]-PSMA-62 (mCRPC)|DRUG: [Ac-225]-PSMA-62 (BCR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Dato-DXd|DRUG: Capecitabine|DRUG: Gemcitabine|DRUG: Eribulin|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Trastuzumab Deruxtecan (T-DXd) With Response-directed Definitive Therapy in Early Stage HER2-positive Breast Cancer (SHAMROCK Study)
Status: ACTIVE_NOT_RECRUITING
Conditions: HER2-positive Breast Cancer
Interventions: DRUG: trastuzumab deruxtecan (T-DXd) (IV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vildagliptin Compared to Gliclazide in Combination With Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: vildagliptin|DRUG: Gliclazide|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Naxitamab and GM-CSF in Combination With IT in Patients With High-Risk Neuroblastoma
Status: TERMINATED
Conditions: Neuroblastoma Recurrent
Interventions: DRUG: Naxitamab and GM-CSF in combination with irinotecan and temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inhaled Vancomycin Tolerability, Safety and Pharmacokinetics
Status: COMPLETED
Conditions: Healthy|Cystic Fibrosis
Interventions: DRUG: AeroVanc|DRUG: IV vancomycin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Convex Skin Barrier in Prevention of Peristomy Skin Complication-Randomized Controlled Trial
Status: UNKNOWN
Conditions: Stoma Colostomy|Stoma Ileostomy
Interventions: DEVICE: convex skin barrier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assesment of Vit D3 Level in Cases of Unexplaind Pregnancy Loss in Assiut
Status: UNKNOWN
Conditions: vitD3 Level in Cases of Recuurent Pregnancy Loss
Interventions: DIAGNOSTIC_TEST: 4-Measurment of serum 25(OH)D3 using Vidas by ELFA meathod.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Influence of Fatty-Acids on Systemic and Subcutaneous Cytokines
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes Mellitus
Interventions: DEVICE: Openflow microperfusion catheter|DIETARY_SUPPLEMENT: Intralipid 20%|OTHER: 0.9% Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Safety and Efficacy of 514G3 in Subjects Hospitalized With Bacteremia Due to Staphylococcus Aureus
Status: COMPLETED
Conditions: Staphylococcus Aureus Bacteremia
Interventions: BIOLOGICAL: 514G3|DRUG: Placebo|DRUG: Standard IV antibiotic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Liposomal Irinotecan and Pembrolizumab For Triple-Negative Breast Cancer (TNBC) With Brain Metastases (BM)
Status: WITHDRAWN
Conditions: Triple Negative Breast Cancer|Brain Metastases
Interventions: DRUG: Pembrolizumab|DRUG: Liposomal Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nordic Walking for Individuals With Osteoporosis, Vertebral Fracture or Hyperkyphosis
Status: COMPLETED
Conditions: Osteoporosis|Hyperkyphosis|Vertebral Fracture
Interventions: BEHAVIORAL: Nordic Walking exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of DHT-Gel to Treat the Symptoms of Low Testosterone in Men 55-80
Status: COMPLETED
Conditions: Hypogonadism|Late Onset Hypogonadism|Low Testosterone
Interventions: DRUG: Dihydrotestosterone (0.7%) in hydroalcoholic gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gymnema Sylvestre vs Berberine in Obesity Gene Expression of Adipokines
Status: COMPLETED
Conditions: Diabetes Mellitus|Obesity
Interventions: DIETARY_SUPPLEMENT: Berberine|DIETARY_SUPPLEMENT: Gymnema sylvestre
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [11C]Carfentanil PET Study of GSK1521498
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Part A Assessing GSK1521498|DRUG: Part B Assessing GSK1521498|DRUG: Part C Assessing Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Newly Diagnosed Standard Risk Acute Lymphoblastic Leukemia in Children
Status: RECRUITING
Conditions: Lymphoblastic Leukemia in Children
Interventions: DRUG: induction: vincristine, L-asparaginase, dexamethasone, intrathecal Ara-C, intrathecal Methotrexate|DRUG: Consolidation: Vincristine, Mecaptopurine, Intrathecal Methotrexate|DRUG: Consolidation: Vincristine, Mecaptopurine, Cyclophosphamide, Cytarabine, L-asparaginase, Intrathecal Methotrexate|DRUG: Interim Maintenance(IM): Vincristine, Methotrexate, Intrathecal Methotrexate|DRUG: Interim Maintenance(IM): Vincristine, Methotrexate, Mercaptopurine, Intrathecal Methotrexate|DRUG: Delayed Intesification(DI): Vincristine, Mercaptopurine, L-asparaginase, Doxorubicin, Cyclophosphamide, Cytarabine, Dexamethasone, Intrathecal Methotrexate|DRUG: Delayed Intesification(DI): Vincristine, L-asparaginase, Doxorubicin, Cyclophosphamide, Cytarabine, Dexamethasone, Intrathecal Methotrexate|DRUG: Maintenance: Vincristine, Mercaptopurine, Methotrexate, Dexamethasone, Intrathecal Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Study: Standard of Care With or Without Atorvastatin for Prevention of GVHD for Matched Unrelated Donor BMT
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia|Acute Lymphocytic Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Atorvastatin|DRUG: Methotrexate|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating Safety of 13-Valent Pneumococcal Conjugate Vaccine in Healthy Elderly Subjects
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine (13vPnC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NGR015: Study in Second Line for Patient With Advanced Malignant Pleural Mesothelioma Pretreated With Pemetrexed
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: NGR-hTNF plus Best Investigator's Choice (BIC)|DRUG: Placebo plus Best Investigator's Choice (BIC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anticonvulsant Mood Stabilizers, Antipsychotic Drugs and the Insulin Resistance Syndrome
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Bipolar Disorder
Interventions: DRUG: ziprasidone vs. aripiprazole|DRUG: aripiprazole vs. ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome)
Status: COMPLETED
Conditions: MPA|PAN or EGPA With FFS=0|At Diagnosis or Within the First 15 Days Following Initiation of Corticosteroids
Interventions: DRUG: corticosteroid and azathioprine|DRUG: corticosteroid and placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Humidity (During CPAP Treatment) on Mucociliary Clearance in Patients With Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: CPAP + ThermoSmart™ humidity|DEVICE: CPAP + Conventional humidity|DEVICE: CPAP + No added humidity
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Azacitidine for Treatment of Therapy Related or Secondary Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Secondary Myelodysplastic Syndrome|Therapy-Related Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing the Pharmacokinetics of FTD as a Component of TAS-102 With FTD Alone
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: TAS-102|DRUG: Trifluridine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Type A and Modified Constraint-Induced Movement Therapy for Poststroke Upper Extremity Spasticity
Status: COMPLETED
Conditions: Stroke
Interventions: OTHER: BtxA+mCIMT|OTHER: BtxA+ conventional rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of Effectiveness of Telerehabilitation for Zone 2 Flexor Tendon Injuries of the Hand
Status: RECRUITING
Conditions: Zone 2 Flexor Tendon Injuries of the Hand
Interventions: OTHER: Telerehabilitation|OTHER: Face-to-face rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Two-phase, Crossover Study to Evaluate the Safety, Tolerability and Pharmacokinetics of APL-1501 ER Tablets
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: APL-1202+APL-1501 ER Tablets 3+APL-1501 ER Tablets 2|DRUG: APL-1501 ER Tablets 3+APL-1202+APL-1501 ER Tablets 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Financial Incentives and Recruitment to the APT Webstudy
Status: RECRUITING
Conditions: Alzheimer Disease|Dementia|Preclinical Alzheimer's Disease|Prodromal Alzheimer's Disease
Interventions: BEHAVIORAL: Financial Incentives|BEHAVIORAL: Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Mechanisms of Post-Bariatric Hypoglycemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypoglycemia
Interventions: DIAGNOSTIC_TEST: Continuous Glucose Monitoring|DIAGNOSTIC_TEST: activity monitor|DIAGNOSTIC_TEST: Mixed meal tolerance test|DIAGNOSTIC_TEST: Glucagon Sensitivity Testing|DIAGNOSTIC_TEST: Hypoglycemic Hyperinsulinemic Clamp|DIAGNOSTIC_TEST: analysis of fecal microbiome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Oxytocin Administration in BDD and OCD
Status: COMPLETED
Conditions: Body Dysmorphic Disorder|Obsessive-compulsive Disorder
Interventions: DRUG: Oxytocin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
Status: UNKNOWN
Conditions: Osteoarthritis|Blood Loss, Surgical|Blood Loss, Postoperative
Interventions: DRUG: Tranexamic Acid (Oral)|DRUG: Tranexamic Acid (Intravenous)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Proof of Concept Study to Evaluate the Safety Profile of Plitidepsin in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Plitidepsin 1.5 mg/day|DRUG: Plitidepsin 2.0 mg/day|DRUG: Plitidepsin 2.5 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare the Oral Bioavailability of Single Doses of Two Vapendavir Drug Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Vapendavir 300 mg tablet|DRUG: Vapendavir 132 mg capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics Study to Evaluate BMS-830216 in Obese Subjects
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: BMS-830216|DRUG: BMS-830216|DRUG: BMS-830216|DRUG: BMS-830216|DRUG: BMS-830216|DRUG: BMS-830216|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Specificity of Dyspnoea Relief With Inhaled Furosemide
Status: COMPLETED
Conditions: Dyspnea
Interventions: DRUG: Furosemide|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploring the Optimal Timing of Minimally Invasive Surgery for Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Time
Interventions: RADIATION: Neoadjuvant chemradiotherapy|PROCEDURE: Minimally invasive esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery
Status: COMPLETED
Conditions: Scoliosis
Interventions: DRUG: Bupivacaine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Confirmation Trial of the Acorn CorCap Cardiac Support Device (CSD) at the Same Time as Mitral Valve Repair
Status: UNKNOWN
Conditions: Heart Failure
Interventions: DEVICE: CorCap CSD
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder Mania
Interventions: DRUG: Aripiprazole|DRUG: Placebo|DRUG: Lithium|DRUG: Valproate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comic Art Creation as Supportive Care in Cancer Patients and Caregivers
Status: COMPLETED
Conditions: Caregiver|Malignant Neoplasm
Interventions: PROCEDURE: Art Therapy|OTHER: Interview|PROCEDURE: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors
Status: COMPLETED
Conditions: Extragonadal Germ Cell Tumor|Testicular Germ Cell Tumor
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: ifosfamide|DRUG: vinblastine sulfate|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Brain Plus Spinal Stimulation for Cervical SCI
Status: COMPLETED
Conditions: Spinal Cord Injuries|Spinal Cord Injury at C5-C7 Level|Tetraplegia/Tetraparesis
Interventions: DEVICE: transcutaneous spinal direct current stimulation (tsDCS) - coronal|DEVICE: transcutaneous spinal direct current stimulation (tsDCS) - caudal|DEVICE: transcutaneous spinal direct current stimulation (tsDCS) - rostral|DEVICE: intermittent theta burst stimulation (iTBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PD-1 Monoclonal Antibody in Pre-treated Lymphoepithelioma-like Carcinoma
Status: UNKNOWN
Conditions: Lymphoepithelioma-Like Carcinoma
Interventions: DRUG: PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Group Acupuncture Treatment Effects for Painful Diabetic Neuropathy (GATE-PDN)
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aerobic Exercise on Pain in Patients With Myogenous Temporomandibular Disorders and Suspicion of Central Sensitization
Status: RECRUITING
Conditions: Temporomandibular Disorder|Central Sensitisation|Myofascial Pain Syndrome|Endurance Training
Interventions: OTHER: Physical therapy combined with aerobic exercise|OTHER: Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-bone Cord Blood Transplantation in Patients With Haematological Malignancies
Status: UNKNOWN
Conditions: High Risk Haematological Malignancies|Advanced Haematological Malignancies
Interventions: PROCEDURE: Intrabone Allogeneic Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of tDCS for Mild Cognitive Impairment
Status: UNKNOWN
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Yband (YDT-201N)|DEVICE: Sham-Yband (YDT-201N)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Direct Antimicrobial Susceptibility Testing on Respiratory Sample of Intensive Care Patient With Suspected VAP
Status: UNKNOWN
Conditions: Ventilator-associated Pneumonia
Interventions: OTHER: Direct Antimicrobial Susceptibility Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging
Status: COMPLETED
Conditions: Liver Lesions
Interventions: DRUG: Sonazoid™|DRUG: SonoVue®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Utility of Telemedicine in the Follow-Up of Patients in Peritoneal Dialysis
Status: UNKNOWN
Conditions: Chronic Kidney Disease Stage 5|Peritoneal Dialysis Complication
Interventions: DEVICE: Claria telemedicine device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Tofacitinib and Prednisolone in the Treatment of Active Takayasu's Arteritis
Status: RECRUITING
Conditions: Takayasu Arteritis
Interventions: DRUG: Tofacitinib 5 MG|DRUG: Prednisolone|OTHER: Placebo of tofacitinib 5mg|OTHER: Placebo of prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chidamide Combined With Exemestane (+/- Goserelin) Versus Neoadjuvant Chemotherapy in Patients of Stage II-III HR-positive/HER2-negative Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Neoplasms
Interventions: DRUG: Chidamide combined with exemestane (+/- goserelin)|DRUG: Chemotherapy with docetaxel plus epirubicin or change of chemotherapy regimen (at the discretion of the clinician)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lurbinectedin + Doxorubicin In Leiomyosarcoma
Status: RECRUITING
Conditions: Advanced Soft-tissue Sarcoma|Metastatic Soft-tissue Sarcoma|Advanced Leiomyosarcoma|Leiomyosarcoma Metastatic
Interventions: DRUG: Lurbinectedin|DRUG: Doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation of Continuous Monitoring of Vital Signs in Children With a Connected Patch
Status: NOT_YET_RECRUITING
Conditions: Vital Signs
Interventions: DEVICE: Monitoring with VT-Patch (Connected device manufactured by VitalTracer)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessing the Safety and Performance of the Endoscopic Linear Cutter Stapler and Reloads (Frankenman) in Colectomy
Status: WITHDRAWN
Conditions: Colon Cancer
Interventions: DEVICE: Endoscopic Linear Cutter Stapler and Reloads (Frankenman)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Brief Treatment for Temporomandibular Pain
Status: COMPLETED
Conditions: Temporomandibular Joint Syndrome|Myofascial Pain Dysfunction Syndrome|Orofacial Pain
Interventions: BEHAVIORAL: Cognitive-Behavioral treatment|BEHAVIORAL: Attention and lifestyle counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics Study of CK-3773274
Status: COMPLETED
Conditions: Obstructive Hypertrophic Cardiomyopathy|Healthy Adult Subjects
Interventions: DRUG: CK-3773274|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of N_Acetylcysteine on Liver Functions in Donors in Living Liver Transplantation
Status: COMPLETED
Conditions: Liver Transplant; Complications
Interventions: DRUG: N-Acetylecysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study of TPI 287 - Temozolomide Combination in Melanoma
Status: TERMINATED
Conditions: Melanoma
Interventions: DRUG: TPI 287|DRUG: Temodar (Temozolomide)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Total Occlusion Percutaneous Coronary Intervention Study
Status: COMPLETED
Conditions: Chronic Total Occlusion|Ischemic Heart Disease|Chronic Total Occlusion of Coronary Artery
Interventions: PROCEDURE: Chronic Total Occlusion Revascularization|DEVICE: GuideLiner® V3 catheter, TrapLiner® catheter, Turnpike® catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque Psoriasis
Status: RECRUITING
Conditions: Psoriasis
Interventions: DRUG: Deucravacitinib|DRUG: Apremilast
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients
Status: COMPLETED
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Aerosolized Calfactant|DEVICE: Solarys
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Margin Status After Pancreaticoduodenectomy for Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Cholangiocarcinoma|Ampullary Cancer
Interventions: DIAGNOSTIC_TEST: Leeds Pathology Protocol (LEEPP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Drug Interaction Study of the Pharmacokinetics of Topiramate and FLUNARIZINE When Given Together or Separately
Status: COMPLETED
Conditions: Human Volunteers|Migraine
Interventions: DRUG: Topiramate; flunarizine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Lung Non-Small Cell Carcinoma|Stage IV Lung Cancer AJCC v8|Stage IVA Lung Cancer AJCC v8|Stage IVB Lung Cancer AJCC v8
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy
Status: COMPLETED
Conditions: Bunionectomy|Pain|Postoperative Pain|Acute Pain
Interventions: DRUG: CG5503 IR|DRUG: Morphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Medial Patellofemoral Ligament Reconstruction With or Without Lateral Retinaculum Release
Status: ACTIVE_NOT_RECRUITING
Conditions: Episodic Patellar Dislocation
Interventions: PROCEDURE: MPFL reconstruction and lateral retinaculum release|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Nutrients Contained in Softgel Capsules vs Tablets
Status: COMPLETED
Conditions: Vision
Interventions: DIETARY_SUPPLEMENT: ICAPS Eye Vitamin and Mineral Supplement - Softgel (full strength)|DIETARY_SUPPLEMENT: ICAPS Eye Vitamin and Mineral Supplement - Softgel (half strength)|DIETARY_SUPPLEMENT: ICAPS Eye Vitamin and Mineral Supplement - Coated Tablets (full strength)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sarcopenia and Risk of Fall in Osteoporotic Postmenopausal Women
Status: UNKNOWN
Conditions: Sarcopenia|Falls Patient|Osteoporosis, Postmenopausal
Interventions: DIAGNOSTIC_TEST: Blood sampling, risk of fall evaluation, and MR acquisition.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Imatinib Mesylate, Gemcitabine, and Capecitabine in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: capecitabine|DRUG: gemcitabine hydrochloride|DRUG: imatinib mesylate|GENETIC: mutation analysis|GENETIC: nucleic acid sequencing|GENETIC: polymerase chain reaction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up Using Patient-Reported Outcome (PRO) Measures in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Diseases
Interventions: BEHAVIORAL: PRO-based follow-up|BEHAVIORAL: PRO-based telephone consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety and Tolerability of DNK333 (25 and 100 mg Bid) in Women With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: DNK333
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity
Status: COMPLETED
Conditions: Exploratory Behavior
Interventions: DIETARY_SUPPLEMENT: tap water|DIETARY_SUPPLEMENT: Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube|DIETARY_SUPPLEMENT: Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole|DIETARY_SUPPLEMENT: 25g Fructose in 300ml tap water|DIETARY_SUPPLEMENT: 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39|DIETARY_SUPPLEMENT: 300ml tap water with 450ppm lactisole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioral Therapy for University Students Diagnosed With Attention-deficit Hyperactivity Disorder (ADHD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Attention-deficit Hyperactivity
Interventions: BEHAVIORAL: Cognitive behavioral therapy for ADHD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Universal Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)-Producing and CD40L Expressing Bystander Cell Line for Tumor Vaccine in Melanoma
Status: COMPLETED
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: Bystander-Based Autologous Tumor Cell Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant SBRT Combined With Lenvatinib and Pucotenlimab for Resectable Hepatocellular Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Resectable Hepatocellular Carcinoma|Macrovascular Invasion|CNLC IIIA Stage
Interventions: DRUG: Neoadjuvant SBRT combined with Lenvatinib and Pucotenlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy, Immunogenicity and Safety of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females
Status: RECRUITING
Conditions: Cervical Cancer|Vulvar Cancer|Vaginal Cancer|CIN1|CIN2|CIN3|VaIN1|VaIN2|VaIN3|Genital Wart|VIN 1|VIN 2|VIN 3|AIS
Interventions: BIOLOGICAL: 9-valent Human Papillomavirus (Types 6, 11, 16, 18,31,33,45,52 and 58) Recombinant Vaccine (Hansenula Polymorpha)|BIOLOGICAL: GARDASIL®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Trial Investigating the Absorption, Metabolism and Excretion After a Single Subcutaneous Dose of [3H]-Semaglutide in Healthy Male Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: semaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT