pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of a Program of Physical Exercise and Electrotherapy on Muscle Strength in Subjects of the Fourth Age
Status: COMPLETED
Conditions: Geriatric Assessment|Muscle Strength|Postural Balance|Body Mass Index
Interventions: OTHER: No intervention|OTHER: Strong progressive strengthening exercises of lower limbs|OTHER: Electrotherapy|OTHER: Electrotherapy+weights
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Gastric Bypass Surgery on Risk of CVD in Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Obese Patients|Type 2 Diabetes Mellitus
Interventions: BEHAVIORAL: Calorie controlled diabetic diet for the control patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas
Status: COMPLETED
Conditions: Neurofibromatosis Type 2|Progressive Vestibular Schwannomas
Interventions: DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hepatic Directed Vesicle (HDV)-Insulin Lispro Versus Insulin Lispro to Further Improve Glycemic Control
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: HDV insulin lispro 100 UNT/ML|DRUG: Insulin Lispro 100 UNT/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study.
Status: COMPLETED
Conditions: Venous Reflux
Interventions: DEVICE: Seg. RF Ablation & ClosureFAST catheter|DEVICE: Endovenous Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Transdiagnostic Cognitive Behavioral Therapy for Improving HIV Treatment Outcomes in South Africa
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV/AIDS|Violence
Interventions: BEHAVIORAL: CETA|OTHER: Short Message Service (SMS) text reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparative Effects of Backward Treadmill Walking and Lower Extremity Cross Training Among Stroke Patients
Status: RECRUITING
Conditions: Stroke
Interventions: OTHER: Backward treadmill walking|OTHER: Lower extremity cross training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Eluting Balloon in Arteriovenous Graft
Status: COMPLETED
Conditions: Kidney Failure, Chronic|Angioplasty|Dialysis
Interventions: DEVICE: paclitaxel-coated balloon, IN. PACT(Invatec-Medtronic, Brescia, Italy)|DEVICE: Plain Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate 2 Doses of GSK Biologicals' Oral Live Attenuated Human HRV Vaccine Co-administered With Either OPV or IPV
Status: COMPLETED
Conditions: Rotavirus Infections
Interventions: BIOLOGICAL: Rotavirus (vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Tenofovir vs. Tenofovir Plus Entecavir in Entecavir-Resistant Chronic Hepatitis B
Status: COMPLETED
Conditions: Chronic Viral Hepatitis B Without Delta-agent
Interventions: DRUG: Tenofovir|DRUG: Tenofovir|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CCM and Implementation of Guideline-Directed Medical Therapy in Patients With Heart Failure (Fix-GDMT-HF)
Status: NOT_YET_RECRUITING
Conditions: The Primary Endpoint is Change in QMS From Baseline(Pre-CCM) to 6 Month Follow up (Post-CCM) of the Optimizer Device Implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Children Immune Functions(2)
Status: COMPLETED
Conditions: Diarrhea|Upper Respiratory Infections
Interventions: DIETARY_SUPPLEMENT: Milk with Bifidobacteria|DIETARY_SUPPLEMENT: Milk with non replicating lactobacilli|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rituximab and DexaBEAM as Salvage Therapy for Relapsed Lymphoma
Status: COMPLETED
Conditions: Relapsed Non-Hodgkin-Lymphoma
Interventions: DRUG: Rituximab and DexaBEAM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avelumab With Chemoradiation for Stage II/III Resectable Esophageal and Gastroesophageal Cancer
Status: COMPLETED
Conditions: Resectable Esophageal Cancer|GastroEsophageal Cancer
Interventions: COMBINATION_PRODUCT: Avelumab combined with Chemoradiation|DRUG: Carboplatin|DRUG: Paclitaxel|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Toothbrushing Habits of Preschool Children, With or Without a Toothbrushing Assisting Application
Status: COMPLETED
Conditions: Dental Plaque|Gingivitis
Interventions: DEVICE: electric tootbrush|DEVICE: manual toothbrush|DEVICE: toothbrushing assisting application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Supplementation in Healthy Russian Population
Status: COMPLETED
Conditions: Heart Health Markers|General Nutritional Status
Interventions: DIETARY_SUPPLEMENT: multivitamin multimineral with phytonutrient supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study With Blinatumomab in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Status: COMPLETED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Berries and Vegetables on Cardiometabolic Risk Markers and Cognitive Functions
Status: COMPLETED
Conditions: Metabolic Syndrome|Inflammation|Aging|Fermentation
Interventions: DIETARY_SUPPLEMENT: berries and vegetables|DIETARY_SUPPLEMENT: control product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: 54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Esketamine|OTHER: Placebo|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare Pharmacokinetics and Pharmacodynamics of GP-40081 to NovoMix® 30 Penfill® in Healthy Subjects
Status: COMPLETED
Conditions: Clamp Study
Interventions: DRUG: GP-40081|DRUG: NovoMix® 30 Penfill®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pragmatic Patient-oriented Extension Study of Dialectical Behavior Therapy Booster Sessions for Youth With and/or at Familial Risk for Bipolar Disorder
Status: RECRUITING
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Dialectical behavioral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment Strategy to Enhance Nrf2 Signaling in Older Adults
Status: RECRUITING
Conditions: Aging Problems
Interventions: DIETARY_SUPPLEMENT: Sulforaphane|DIETARY_SUPPLEMENT: Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Disease-modifying Properties of Lithium in the Neurobiology of Alzheimer's Disease
Status: UNKNOWN
Conditions: Cognitive Impairment|Alzheimer Disease
Interventions: DRUG: Lithium Carbonate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison Of Dexmedetomidine and Fentanyl In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy.
Status: COMPLETED
Conditions: Cholecystectomy|Elective Surgery
Interventions: DRUG: Dexmedetomidine|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Invasive Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Pertuzumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Atezolizumab|PROCEDURE: Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability and Pharmacokinetics of Cobimetinib in Combination With Pictilisib in Patients With Locally Advanced or Metastatic Solid Tumors
Status: TERMINATED
Conditions: Solid Tumors
Interventions: DRUG: Cobimetinib|DRUG: Pictilisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-shot Adductor Canal Block With Levobupivacaine and Dexmedetomidine in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Adductor Canal Block|Levobupivacaine|Dexmedetomidine
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of a Plant-based Meat Meal Versus an Animal Meat Meal on Erectile Function in Healthy Men.
Status: RECRUITING
Conditions: Erectile Dysfunction
Interventions: OTHER: Animal-based meal|OTHER: Plant-based meat meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: mFOLFIRI Combine With Nimotuzumab Second Line Chemotherapy for Squamous-cell Carcinoma of the Esophagus
Status: UNKNOWN
Conditions: Advanced Esophageal Carcinoma
Interventions: DRUG: mFOLFIRI+Nimotuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two-fraction Versus Five-fraction Stereotactic Radiotherapy for Localized Prostate Cancer
Status: RECRUITING
Conditions: PROSTATE CANCER
Interventions: RADIATION: Two-fraction stereotactic radiotherapy|RADIATION: Five-fraction stereotactic radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abdominal Obesity, Cardiovascular Inflammation, and Effects of Growth Hormone Releasing Hormone Analogue
Status: WITHDRAWN
Conditions: Abdominal Obesity
Interventions: DRUG: Tesamorelin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1.
Status: TERMINATED
Conditions: Pancreatic Ductal Adenocarcinoma|Colorectal Cancer|Gastric Cancer|Squamous Cell Carcinoma of the Head and Neck|Bone Cancer|Advanced Cancer|Recurrent Disease|Metastatic Tumours
Interventions: DRUG: 177Lu-3BP-227 (also called 177Lu-IPN01087)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Project to Improve Communication About Serious Illness - Pilot Study
Status: COMPLETED
Conditions: Malignant Neoplasm|Leukemia, Lymphocytic, Chronic, B-Cell|Lung Disease Chronic|Congestive Heart Failure|Liver Failures, Chronic|Renal Insufficiency, Chronic|Dementia|Diabetes Complications|Peripheral Vascular Disease|Frail Elderly
Interventions: BEHAVIORAL: Jumpstart Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impedance Spectroscopy in Detection of Obstetric Anal Sphincter Injuries
Status: COMPLETED
Conditions: Obstetric Anal Sphincter Injury|Delivery, Obstetric
Interventions: DIAGNOSTIC_TEST: Blood and faeces tests|DEVICE: Impedance spectroscopy test|DIAGNOSTIC_TEST: Full gynecological and proctological examination|DIAGNOSTIC_TEST: Transanal ultrasonography|DIAGNOSTIC_TEST: Anorectal manometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Camrelizumab Combined With Local Treatment in NSCLC Patients With BM
Status: UNKNOWN
Conditions: NSCLC Stage IV|Brain Metastases|Immunotherapy
Interventions: DRUG: Immunotherapy|RADIATION: WBRT|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVaxTM-JE and JE-VAX
Status: COMPLETED
Conditions: Japanese Encephalitis
Interventions: BIOLOGICAL: ChimeriVax™-JE vaccine|BIOLOGICAL: JE-VAX® vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Hepatitis C Treatment Naive Genotype 1 Consensus Interferon Trial
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: consensus interferon (Interferon Alfacon-1) and ribavirin|DRUG: Consensus Interferon alfa (CIFN) and ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty
Status: UNKNOWN
Conditions: Osteoarthritis
Interventions: PROCEDURE: Waiting time (access time to Total joint replacement)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating Infrasonic Hemodynography
Status: RECRUITING
Conditions: Aortic Stenosis|Mitral Regurgitation|Pulmonary Hypertension|Heart Failure, Systolic|Cardiovascular Diseases|Coronary Artery Disease
Interventions: OTHER: MindMics earbud
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Diagnostic Yield and Safety of Transbronchial Lung Biopsy Using Cryoprobes Versus Conventional Forceps. A Multicenter Study
Status: COMPLETED
Conditions: Lung Diseases, Interstitial
Interventions: PROCEDURE: Transbronchial lung biopsy.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Sickle Cell Disease
Interventions: GENETIC: DREPAGLOBE drug product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Acute Myelocytic Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Remifentanil in Pediatric Population
Status: COMPLETED
Conditions: Infant, Preterm
Interventions: DRUG: low dose remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Operational Research Management for Children With Severe Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: OTHER: Amoxycilline, Cephradine followed by follow up on day 3|OTHER: Injectable ampicillin followed by urgent referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Landiolol for Rate Control in Decompensated Heart Failure Due to Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation|Atrial Fibrillation Rapid|Acute Heart Failure|Left Ventricular Dysfunction
Interventions: DRUG: Intensive heart rate control with landiolol|DRUG: Standard approach to heart rate control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Anaplastic Astrocytoma|Glioblastoma|Malignant Glioma
Interventions: RADIATION: Radiation Therapy|DRUG: Temozolomide|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Pemetrexed Disodium in Treating Patients With Refractory Hormone-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Hormone-resistant Prostate Cancer|Recurrent Prostate Cancer
Interventions: DRUG: oxaliplatin|DRUG: pemetrexed disodium|OTHER: questionnaire administration|OTHER: laboratory biomarker analysis|GENETIC: reverse transcriptase-polymerase chain reaction|GENETIC: polymorphism analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicomponent Exercise Program on the Intrinsic Capacity (ICOPE) of Community-dwelling Older Adults in Primary Care
Status: NOT_YET_RECRUITING
Conditions: Healthy Ageing
Interventions: OTHER: Vivifrail multicomponent exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of NG-641 and Pembrolizumab in Squamous Cell Carcinoma of the Head and Neck
Status: ACTIVE_NOT_RECRUITING
Conditions: Squamous Cell Carcinoma of the Head and Neck
Interventions: BIOLOGICAL: NG-641|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Registry Trial for Single Port Robot-assisted Nipple Sparing Mastectomy (SPrNSM)
Status: COMPLETED
Conditions: Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Ductal Carcinoma in Situ|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|BRCA1 Mutation|BRCA2 Mutation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Adult Patients With Chronic Plaque Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: Bimekizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stroke Prevention in Sickle Cell Anemia (STOP 1)
Status: COMPLETED
Conditions: Anemia, Sickle Cell|Cerebral Embolism and Thrombosis|Cerebrovascular Disorders|Hematologic Diseases|Hemoglobinopathies
Interventions: PROCEDURE: blood transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: PREVENTION
Clinical trial: SBRT Alone or Followed by Niraparib for Oligometastases or Oligoprogression in Ovarian Cancer Following PARPi Therapy
Status: RECRUITING
Conditions: Ovarian Cancer Recurrent
Interventions: DRUG: Niraparib oral capsule|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cancer Localization in the Prostate With F-18 Fluorocholine Positron Emission Tomography
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: Fluourine-18 Fluoromethylcholine PET/CT Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Seated Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project
Status: NOT_YET_RECRUITING
Conditions: Peripheral Nervous System Diseases|Gait Disorders, Neurologic|Foot Drop|Mobility Limitation
Interventions: DEVICE: Seated Ankle Robot Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of VR on Pain, Anxiety And Fear During Venipuncture in Children
Status: COMPLETED
Conditions: Pain, Acute|Anxiety|Fear
Interventions: DEVICE: Virtual Reality|DEVICE: Bubbles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dual Task Training for Balance in Older Adults
Status: COMPLETED
Conditions: Geriatrics
Interventions: OTHER: Warm-up exercise|OTHER: Motor-Cognitive exercise|OTHER: Motor-Motor exercise|OTHER: Cool-down exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Adjuvant Chemotherapy|OTHER: Radiographic surveillance|OTHER: 14-Gene Prognostic Assay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of PENNVAX™-B (Gag, Pol, Env) + Electroporation in HIV-1 Infected Adult Participants
Status: COMPLETED
Conditions: HIV-1 Infection|HIV Infections
Interventions: BIOLOGICAL: PENNVAX-B
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Insulin Detemir and Gliclazide-MR Treatments on Endothelial Functions in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Gliclazide MR|DRUG: Insulin Detemir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Soluble Phosphate in Humans
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: P1000/Ca0|DIETARY_SUPPLEMENT: P1000/Ca500|DIETARY_SUPPLEMENT: P1000/Ca1000|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Care.Coach Avatars for Improvement of Outcomes in Hospitalized Elders, Including Mitigation of Falls and Delirium: a Multi-Site Clinical Study
Status: COMPLETED
Conditions: Delirium|Fall Injury
Interventions: BEHAVIORAL: care.coach Avatar (HELP-Protocolized)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Safety and Efficacy of Plasmodium Falciparum Malaria Protein 010 (FMP010) Administered With Adjuvant AS01B
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: Plasmodium falciparum Malaria Protein 010 (FMP010)|BIOLOGICAL: Rabipur
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Positron Lymphography Via Intracervical 18F-FDG Injection for Pre-surgical Lymphatic Mapping in Stage IB1 Cervical Cancer and High-grade Endometrial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer|Endometrial Cancer
Interventions: RADIATION: 18F-Fluorodeoxyglucose (18F-FDG)|DEVICE: PET/CT imaging|DEVICE: PET/MRI imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Influence of Different Fluid Therapy Measures on the Postoperative Outcome in Fast Track of Colon Cancer.（FTSlapCC)
Status: UNKNOWN
Conditions: Colon Carcinoma
Interventions: PROCEDURE: fluid administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia
Status: RECRUITING
Conditions: Leukemia
Interventions: DRUG: Vyxeos|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LESS Surgery Versus Conventional Multiport Laparoscopy in Ovarian Drilling
Status: COMPLETED
Conditions: Successful Surgical Procedure|Operative Time|Cosmetic Outcome|Intra- and Post- Operative Complications
Interventions: DEVICE: laparoscopic ovarian drilling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Trilipix Effects on Lipids and Arteries
Status: TERMINATED
Conditions: Dyslipidemia
Interventions: DRUG: Trilipix|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Laser Therapy for Vulvovaginal Symptoms in Breast Cancer Patients
Status: UNKNOWN
Conditions: Vulvovaginal Atrophy|Genitourinary Symptoms and Ill-Defined Conditions
Interventions: DEVICE: CO2 Fractional Ablative Laser|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Reducing Malnutrition and Helminthic Infectious Disease Among Primary School Children by the School Nurses
Status: COMPLETED
Conditions: Malnutrition, Child|Intestinal Worms
Interventions: BEHAVIORAL: Health Awareness Program TO Reduce Malnutrition and Helminth Infestation among Primary School children
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Teriparatide on Hip Fracture Healing
Status: COMPLETED
Conditions: Femur Neck Fracture
Interventions: DRUG: Teriparatide|DRUG: Placebo|DIETARY_SUPPLEMENT: Calcium supplementation|DIETARY_SUPPLEMENT: Vitamin D supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of Hepatic Resection for Liver Cancer With PVTT, HVTT or IVCTT After Initial Ate/Bev
Status: RECRUITING
Conditions: Venous Thrombosis
Interventions: DRUG: Atezolizumab|PROCEDURE: Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women
Status: COMPLETED
Conditions: Forearm Fracture
Interventions: DRUG: Salmon calcitonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: NCT Neuro Master Match - N²M² (NOA-20)
Status: COMPLETED
Conditions: Glioblastoma, Adult
Interventions: DRUG: APG101|DRUG: Alectinib|DRUG: Idasanutlin|DRUG: Atezolizumab|DRUG: Vismodegib|DRUG: Temsirolimus|DRUG: Palbociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualised Dose Optimisation of Ganciclovir in Immunocompromised Children Trial (ID-MAGIC)
Status: NOT_YET_RECRUITING
Conditions: Cytomegalovirus Viraemia
Interventions: DRUG: Standard dosing of IV ganciclovir|DRUG: Personalised dosing of IV ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acotec DCB Post Market Clinical Follow-up
Status: RECRUITING
Conditions: Peripheral Artery Disease
Interventions: DEVICE: AcoArt Orchid (0.035"), AcoArt Tulip (0.018") and AcoArt Litos (0.014") percutaneous transluminal angioplasty (PTA) paclitaxel drug coated balloon catheter manufactured by Acotec Scientific Co., Ltd.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Rabeprazole in Infants With Gastroesophageal Erosive Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux
Interventions: DRUG: Rabeprazole sodium 5 mg|DRUG: Rabeprazole sodium 10 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir and Ribavirin in Participants With Hepatitis C Virus Who Did Not Respond to Treatment in a Previous AbbVie Clinical Study
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: Sofosbuvir|DRUG: Glecaprevir/Pibrentasvir|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment.
Status: COMPLETED
Conditions: Pain
Interventions: PROCEDURE: Ibuprofen for post operative pain|DRUG: Acetaminophen 325 mg for Flare up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The SEAPORT 1 Study: Evaluation of the Safety and Tolerability of INZ-701 in Adults With End-Stage Kidney Disease Undergoing Hemodialysis
Status: ACTIVE_NOT_RECRUITING
Conditions: Calciphylaxis
Interventions: DRUG: INZ-701
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Extended All-Ceramic Fixed Partial Dentures Based on Zircon-Oxide Ceramics.
Status: COMPLETED
Conditions: Tooth Loss, Teeth Replaced Using All Ceramic FPDs
Interventions: DEVICE: All ceramic FPDs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mycophenolate Mofetil for the Prophylaxis of Graft-versus-host Disease in High Risk Allogeneic Stem Cell Transplantation
Status: UNKNOWN
Conditions: Graft vs Host Disease|Hematopoietic Stem Cell Transplantation
Interventions: DRUG: mycophenolate mofetil, methotrexate, cyclosporin|DRUG: Methotrexate and cyclosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Virtual Rehabilitation for Cancer Survivors
Status: RECRUITING
Conditions: Breast Cancer, Stage 0|Colorectal Cancer Stage I|Head and Neck Cancer Stage I|Lymphoma|Breast Cancer Stage I|Breast Cancer Stage II|Breast Cancer Stage III|Colorectal Cancer Stage II|Colorectal Cancer Stage III|Head and Neck Cancer Stage II|Head and Neck Cancer Stage III|Lymphoproliferative Disorders
Interventions: BEHAVIORAL: CaRE@Home intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study on the Protective Effect of a Flexible Sleeve Penis Protection Device on Penis After Circumcision
Status: ENROLLING_BY_INVITATION
Conditions: Circumcision, Male
Interventions: OTHER: wrapped with the Flexible Sleeve Penis Protection Device|OTHER: wrapped with traditional gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clopidogrel in High-risk Patients With Acute Non-disabling Cerebrovascular Events
Status: COMPLETED
Conditions: Stroke|Transient Ischemic Attack
Interventions: DRUG: Clopidogrel|DRUG: Placebo of clopidogrel and Asprin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study in Healthy People to Test How 2 Different Formulations of BI 695501 Are Taken up by the Body When Given as an Injection
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 695501 - higher concentration|DRUG: BI 695501 - lower concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity Study of Vacc-4x Versus Placebo in Patients Infected With HIV
Status: COMPLETED
Conditions: HIV I Infection
Interventions: DRUG: Vacc-4x|DRUG: Sterile water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Liposomal Doxorubicin and Gemcitabine in Treating Women With Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: gemcitabine hydrochloride|DRUG: pegylated liposomal doxorubicin hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload
Status: COMPLETED
Conditions: Iron Overload
Interventions: DRUG: Deferasirox
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Femoral Artery Block for Reduction of Tourniquet Induced Hypertension
Status: NOT_YET_RECRUITING
Conditions: Tourniquets|Anesthesia, Conduction|Anesthetics, Local|Hypertension
Interventions: OTHER: Femoral artery block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: BIOLOGICAL: Tezepelumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsule
Status: COMPLETED
Conditions: Cataract
Interventions: OTHER: dye of lutein, zeaxanthin, trypan blue
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Seviteronel in Combination With Chemotherapy in Androgen-receptor Positive Metastatic Triple-negative Breast Cancer
Status: RECRUITING
Conditions: Triple Negative Breast Cancer
Interventions: DRUG: Seviteronel-D (Seivteronel in combination with dexamethasone)|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Camrelizumab Combined With Nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer
Status: UNKNOWN
Conditions: Metastatic Pancreatic Cancer
Interventions: DRUG: Camrelizumab|DRUG: Nab paclitaxel|DRUG: Gemcitabine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus Open Appendectomy Prospective Randomized Control Study
Status: NOT_YET_RECRUITING
Conditions: Appendicitis Acute
Interventions: PROCEDURE: Open appendectomy|PROCEDURE: Conventional Lap appendectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NeSST2: The Development of a Noninvasive Short Synacthen Test
Status: RECRUITING
Conditions: Adrenal Suppression
Interventions: DRUG: nasal Tetracosactide|DRUG: IV tetracosactide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Apneic Oxygenation Via Nasal Cannulae: 15 L/Min vs High-Flow
Status: COMPLETED
Conditions: Apneic Oxygenation
Interventions: DRUG: 0 L/min oxygen via conventional nasal cannulae|DRUG: 15 L/min oxygen via conventional nasal cannulae|DRUG: 60 L/min oxygen via high-flow nasal cannulae
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of a Positive Psychology Intervention for Older Adults (RESET) During the COVID-19 Pandemic
Status: RECRUITING
Conditions: Depressive Symptoms|Anxiety|Chronic Pain|Fatigue|Loneliness|Stress, Psychological
Interventions: BEHAVIORAL: RESET|BEHAVIORAL: Wellness Check Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Single Administration and Dose Increment of Recombinant Human Serum Albumin/Erythrocyte Fusion Protein for Injection
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: BIOLOGICAL: Recombinant human serum albumin/erythropoietin fusion protein|BIOLOGICAL: Recombinant erythropoietin injection (CHO cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Boost Vaccinations of Pancreatic Tumor Cell Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: PANC 10.05 pcDNA-1/GM-Neo and PANC 6.03 pcDNA-1 neo vaccine.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Routine Angiography Follow-Up After Percutaneous Coronary Intervention in High-Risk Patients
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Routine Angiography Follow-up|DIAGNOSTIC_TEST: Routine Clinical Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gait Patterns After Intraarticular Treatment of Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: hyaluronic acid|DRUG: triamcinolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: URAISE: Ultrasound Regional Anaesthesia Interpretation Skill Evaluation
Status: RECRUITING
Conditions: Anesthesia
Interventions: OTHER: Preliminary testing|OTHER: Psychometric main study testing (Phase 5)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Trial of Talabostat and Gemcitabine in Patients With Stage IV Adenocarcinoma of the Pancreas
Status: TERMINATED
Conditions: Pancreatic Cancer|Neoplasm Metastasis|Adenocarcinoma
Interventions: DRUG: talabostat mesylate tablets|DRUG: gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Abemaciclib on Metformin and Iohexol in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Abemaciclib|DRUG: Metformin|DRUG: Iohexol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Effects of the Addition of Diathermy by Emission of Radiofrequency to Therapeutic Exercise in Patellofemoral Pain Syndrome Patients
Status: COMPLETED
Conditions: Patellofemoral Pain Syndrome|Patellofemoral Pain|Patello Femoral Syndrome
Interventions: DEVICE: Diathermy by emission of Radiofrequency|OTHER: Therapeutic exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gravity Flow Technique to Validate Proper Location of Epidural Needle Tip on Obese Parturients
Status: COMPLETED
Conditions: Epidural/Anesthesia
Interventions: OTHER: Cold Stimulus (Ice)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Assess PK, Safety and Tolerability in Patients With DM and CKD
Status: COMPLETED
Conditions: Chronic Kidney Disease|Chronic Kidney Disease, Stage 3 (Moderate)|Chronic Kidney Disease, Stage 4 (Severe)|Diabetes
Interventions: DRUG: DM199
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Xylometazoline During Nasal Flexible Bronchoscopy
Status: COMPLETED
Conditions: Bronchoscopy
Interventions: DRUG: Xylometazoline|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Novel PET Tracer Gallium [68Ga]/ Fluorine [18F] -FAPI-04 in the Diagnosis of Cardiovascular Diseases
Status: RECRUITING
Conditions: Myocardial Fibrosis
Interventions: DRUG: 68Ga/18F-FAPI-04
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures
Status: COMPLETED
Conditions: Infertility, Female|Infertility of Uterine Origin|Asherman Syndrome
Interventions: BIOLOGICAL: bone marrow-derived MSC and HRT|OTHER: hormonal replacement therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimal Residual Disease Quantification by Next-generation Sequencing in Pediatric B-ALL Children Patients Treated With Blinatumomab Consolidation
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: DRUG: Blinatumomab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Twin Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis
Status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Interventions: DRUG: ARQ-151 0.3% cream|DRUG: ARQ-151 vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension of Prior Study Evaluating Safety and Tolerability of Two Doses of Betaseron® to Treat Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Interferon beta 1b (Betaseron, BAY86-5046)|DRUG: Interferon beta 1b (Betaseron, BAY86-5046)|DRUG: Interferon beta 1b (Betaseron, BAY86-5046)|DRUG: Interferon beta 1b (Betaseron, BAY86-5046)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Biomarker Study of Secukinumab in Rheumatoid Arthritis (RA) Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Placebo|DRUG: Secukinumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temozolomide in Treating Patients With Invasive Pituitary Tumors
Status: WITHDRAWN
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: temozolomide|GENETIC: DNA methylation analysis|GENETIC: microarray analysis|GENETIC: protein expression analysis|GENETIC: proteomic profiling|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT