pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effectiveness of Arthrocentesis and the Occlusal Splint in Treatment of the TMJ
Status: COMPLETED
Conditions: Temporomandibular Joint Disc Displacement|Anterior Disc Displacement
Interventions: PROCEDURE: Occlusal splint|PROCEDURE: Arthrocentesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation
Status: COMPLETED
Conditions: Ventricular Tachycardia|Premature Ventricular Contraction|Stroke
Interventions: DRUG: DOAC|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Unrelated Double Umbilical Cord Blood Units Transplantation
Status: UNKNOWN
Conditions: Leukemia, Myeloid, Acute|Leukemia, Lymphoblastic, Acute|Leukemia, Myeloid, Chronic
Interventions: DRUG: Stem cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-level Laser Therapy for the Treatment of Diabetic Foot Ulcer
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: PROCEDURE: Control LED shoe arm|PROCEDURE: Laser Shoe arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ambu Aura-i and Air-Q Intubating Laryngeal Airways as a Conduit for Tracheal Intubation in Children
Status: COMPLETED
Conditions: Tracheal Intubation in Children
Interventions: DEVICE: Ambu Aura-i size 1.5|DEVICE: air-Q ILA size 1.5|DEVICE: Ambu Aura-i size 2|DEVICE: air-Q ILA size 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose:
Clinical trial: Bioequivalence Study of Montelukast 10 mg Tablets
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Montelukast 10 mg|DRUG: Montelukast 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Basket Trial of Neoantigen Synthetic Long Peptide Vaccines in Patients With Advanced Malignancy
Status: ENROLLING_BY_INVITATION
Conditions: Cancer|Solid Tumor
Interventions: BIOLOGICAL: Personalized Synthetic Long Peptide Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Fluoxetine+Olanzapine|DRUG: Olanzapine|PROCEDURE: Functional Magnetic Resonance Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Benefits of Glycopyrrolate on Intubation With Rigid-videostylet (OptiScope®)
Status: COMPLETED
Conditions: Cholecystitis, Acute
Interventions: DRUG: Glycopyrrolate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Single Dose Escalation Study of PF-04360365 In Subjects With Mild To Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: PF-04360365 1 mg/kg|BIOLOGICAL: PF-04360365 3 mg/kg|BIOLOGICAL: PF-04360365 5 mg/kg|BIOLOGICAL: PF-04360365 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of A140 and Erbitux Combined With mfolfox6 to Evaluate Efficacy and Safety of First-line Treatment for Ras Wild-type mCRC
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Double blind control period A140|DRUG: Open single period A140
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Haemocomplettan® P During Aortic Replacement
Status: COMPLETED
Conditions: Aortic Aneurysm
Interventions: BIOLOGICAL: Haemocomplettan® P|BIOLOGICAL: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Multi-institutional Study Assessing Simultaneous In-field Boost Helical Tomotherapy for 1-3 Brain Metastases
Status: COMPLETED
Conditions: Metastasis to Brain of Primary Cancer
Interventions: RADIATION: Whole Brain XRT 30Gy/10 fractions with
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial on Prophylactic Clipping to Prevent Post-polypectomy Bleeding After Colonoscopy in Direct Oral Anticoagulant Users
Status: RECRUITING
Conditions: Post Polypectomy Bleeding
Interventions: PROCEDURE: Endoclip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Efficiacy of Mecobalamine in the Treatment of Long-term Pain in Women Diagnosed With Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DRUG: Mecobalamin 5 MG|OTHER: Placebo Comparator : NaCl 9 mg/ml
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Purpose of the This Study is to Evaluate the Spirometric Effect (Trough FEV1) of Umeclidinium/Vilanterol 62.5/25 mcg Once Daily Compared With Tiotropium 18mcg Once Daily Over a a 12-week Treatment Period in Subjects With COPD Who Continue to Have Symptoms on Tiotropium
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Umeclidinium/Vilanterol 62.5/25 mcg|DRUG: Tiotropium 18 mcg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Total Fat Pad Excision Leads to Worse Isokinetic Performance in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee|Knee Arthritis
Interventions: PROCEDURE: Total infrapatellar fat pad excision|PROCEDURE: Partial infrapatellar fat pad excision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Metformin Hydrochloride Tablets 1000 mg Tablets of Dr. Reddy's Laboratories Limited Under Fasting Condition
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Metformin|DRUG: Glucophage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Effect of Simple Clinical Maneuver on Shoulder and Abdominal Pain a Laparascopic Gynecological Surgery:a Prospective Randomised Trial
Status: COMPLETED
Conditions: Effect of CO2 Was Removed by Means Trandelenburg Position at Laparascopic Surgery
Interventions: BEHAVIORAL: CO2 was removed by means of trandelenburg positions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Nebulised Beclometasone in Viral Wheezing Prophylaxis
Status: COMPLETED
Conditions: Bronchial Spasm|Respiratory Sounds|Respiratory Tract Infections
Interventions: DRUG: Beclomethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Topical Tofacitinib for the Treatment of Alopecia Areata and Its Variants
Status: COMPLETED
Conditions: Alopecia Areata|Alopecia Totalis|Alopecia Universalis
Interventions: DRUG: Tofacitinib ointment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Precise Treatment of Ceftazidime-Avibactam in Patients With CRO Infections Under the Guidance of TDM and PPK Model
Status: NOT_YET_RECRUITING
Conditions: ECMO|Carbapenem-Resistant Enterobacteriaceae Infection
Interventions: DRUG: ceftazidime avibactam
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fed Study of Mylan Nitrofurantoin Monohydrate/Macrocrystals Capsules 100 mg and Macrobid® Capsules 100 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Nitrofurantoin Monohydrate/Macrocrystals Capsules 100 mg|DRUG: Macrobid® Capsules 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study on Prevalence, Protection and Recovery From COVID-19 in Seasoned Yoga Practitioners in Comparison to Age and Gender Matched Controls
Status: COMPLETED
Conditions: Covid19|Stress|Anxiety Depression
Interventions: BEHAVIORAL: Simha Kriya|BEHAVIORAL: Reading a Book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate SIMPONI (Golimumab) Therapy in Children, Adolescents and Young Adults With Pre-Symptomatic Type 1 Diabetes
Status: COMPLETED
Conditions: Pre-Symptomatic Type 1 Diabetes
Interventions: DRUG: Golimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SWOG-9023, DNA Analysis of Tumor Tissue From Patients With Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: GENETIC: DNA ploidy analysis|GENETIC: DNA stability analysis|GENETIC: chromosomal translocation analysis|GENETIC: cytogenetic analysis|OTHER: flow cytometry|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of 12-week Exercises on Alexithymia, Depression and Quality of Life in Geriatric Individuals
Status: UNKNOWN
Conditions: Depression|Alexithymia|Quality of Life|Physical Inactivity
Interventions: BEHAVIORAL: Aerobic and ResistanceExercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery
Status: COMPLETED
Conditions: Drug Interactions|Anesthesia, Conduction
Interventions: DRUG: Propofol and Remifentanil|DRUG: Propofol and Remifentanil|DRUG: Sevoflurane and Remifentanil|DRUG: Sevoflurane and Remifentanil|DRUG: SPR 1|DRUG: SPR2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Pelvic Floor Stimulation on the Pelvic Floor Function in Cervical Cancer Patients With Type III Hysterectomy
Status: UNKNOWN
Conditions: Lower Urinary Tract Symptoms
Interventions: DEVICE: PHENIX USB 8.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Controlled Study of Improved Javelin Side Recumbent Position and Conventional Postural Placement
Status: COMPLETED
Conditions: Nurse-Patient Relations
Interventions: PROCEDURE: To explore the comparative study of different positioning methods in robot assisted laparoscopic pyeloplasty.|DEVICE: To discuss the comparative study of different position placement methods of renal pelvis ureteroplasty on the Da Vinci robotic Xi platform
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Advanced Understanding of Staphylococcus Aureus and Pseudomonas Aeruginosa Infections in EuRopE - ICU
Status: COMPLETED
Conditions: Pneumonia|Pneumonia, Ventilator-Associated|Nosocomial Pneumonia
Interventions: OTHER: Various observed exposure(s) of interest
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mechanism Underlying Beta-cell Failure in Obese African Americans With History of Hyperglycemic Crises
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Intralipid 20%|DRUG: Glucose infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effect of Blood Flow Restricted High-Intensity Resistive Training
Status: COMPLETED
Conditions: High-Intensity Interval Training|Blood Flow Restriction Exercise
Interventions: OTHER: high intensity with blood flow restriction|OTHER: high intensity without blood flow restriction group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy
Status: COMPLETED
Conditions: Hypertension
Interventions: DEVICE: Ambulatory blood pressure monitoring|PROCEDURE: Chronotherapy, timing of antihypertensive medication|DRUG: ACEI (including spirapril, enalapril, quinapril, lisinopril)|DRUG: ARB (including valsartan, telmisartan, olmesartan)|DRUG: beta blockers (including nebivolol, atenolol, carvedilol)|DRUG: diuretics (torasemide, indapamide, HTCZ) and doxazosin|PROCEDURE: Combination therapy in essential hypertension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Anetumab Ravtansine in Hepatic or Renal Impairment
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Anetumab ravtansine (BAY94-9343)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Intravenous Immunoglobulin in Patients With Hemorrhagic Fever With Renal Syndrome: a Prospective Study
Status: RECRUITING
Conditions: HFRS (Hemorrhagic Fever With Renal Syndrome)
Interventions: DRUG: IVIG 20g/d|DRUG: IVIG 10g/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation
Status: COMPLETED
Conditions: Irritable Bowel Syndrome|Constipation
Interventions: DRUG: Lubiprostone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Punicalagin and Hydroxytyrosol Mixture on Different Inflammatory Markers
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: punicalagin and hydroxytyrosol mixture|DIETARY_SUPPLEMENT: Control supplement (maltodextrin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations
Status: UNKNOWN
Conditions: Surgical Wound|Wound Heal|Amputation
Interventions: DEVICE: PrevenaTM Device|OTHER: Standard Dry Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SON-080 in Patients With Persistent Chemotherapy-induced Peripheral Neuropathy (CIPN)
Status: TERMINATED
Conditions: Chemotherapy-induced Peripheral Neuropathy (CIPN)
Interventions: BIOLOGICAL: SON-080
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise Intervention in Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer
Status: WITHDRAWN
Conditions: Cancer Survivor|Central Obesity|Estrogen Receptor Positive|Postmenopausal|Progesterone Receptor Positive|Stage I Breast Cancer|Stage IA Breast Cancer|Stage IB Breast Cancer|Stage II Breast Cancer|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage III Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer
Interventions: BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|BEHAVIORAL: Exercise Intervention|OTHER: Informational Intervention|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peginterferon Alpha-2a Maintenance Therapy for Portal Hypertension in Patients With Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C|Cirrhosis|Fibrosis
Interventions: DRUG: Peginterferon Alpha-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety and Efficacy of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren's Syndrome
Status: COMPLETED
Conditions: Sjogren's Syndrome
Interventions: DRUG: Lanraplenib|DRUG: Filgotinib|DRUG: Tirabrutinib|DRUG: Lanraplenib placebo|DRUG: Filgotinib placebo|DRUG: Tirabrutinib placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pivotal Study to Evaluate Efficacy and Safety of SP5M002 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteoarthritis
Interventions: DEVICE: SP5M002 inj|DEVICE: Synovian inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Lactobacillus Rhamnosus TCELL-1 and Colorectal Cancer
Status: UNKNOWN
Conditions: Staged III Colorectal Cancer Receiving Adjuvant Chemotherapy
Interventions: DIETARY_SUPPLEMENT: Oral Lactobacillus rhamnosus TCELL-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Phase I Clinical Trial of Tremelimumab Plus MEDI3617 in Patients With Unresectable Stage III or Stage IV Melanoma
Status: COMPLETED
Conditions: Metastatic Melanoma
Interventions: DRUG: Tremelimumab|DRUG: MEDI3617
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recombinant Anti-tumor and Anti-virus Protein for Injection in Treatment of Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Recombinant anti-tumor and anti-virus protein for injection|DRUG: Recombinant anti-tumor and anti-virus protein for injection|OTHER: Saline Injection|DRUG: Recombinant anti-tumor and anti-virus protein for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Does Training on a Virtual Reality Bronchoscopy Simulator Improve Performance of Bronchoscopic Intubation in Patients?
Status: COMPLETED
Conditions: Endotracheal Intubation
Interventions: DEVICE: Simulator (ORSIM) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Next Generation ORS: Controlled Trial Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea
Status: RECRUITING
Conditions: Diarrhea|Cholera
Interventions: DRUG: Next Generation ORS (oral rehydration solution) (including placebo|DRUG: Current standard control ORS (oral rehydration solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Dermal Analgesia Provided by the Application of Lidocaine and Prilocaine Cream 5% on the Puncture Site of Axillary Blocks
Status: COMPLETED
Conditions: Surgery Scheduled
Interventions: DRUG: Lidocaine-Prilocaine 5%|DRUG: DEXERYL
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early Breast Cancer - Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: nab-Paclitaxel|DRUG: Gemcitabine|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LUS in Aortic Stenosis Patients Undergoing TAVR
Status: UNKNOWN
Conditions: Transcatheter Aortic Valve Replacement|Lung Ultrasound|Severe Aortic Valve Stenosis|Pulmonary Congestion
Interventions: PROCEDURE: Transfemoral TAVR (Transcatheter aortic valve replacement)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention
Status: COMPLETED
Conditions: Cardiovascular Disease|Interventional Cardiology
Interventions: DRUG: Aspirin|DRUG: Placebo|DRUG: ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)
Status: COMPLETED
Conditions: Kidney Calculi|Urologic Diseases|Benign Prostatic Hypertrophy
Interventions: DRUG: Tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Combination Chemotherapy, and Rituximab as First-Line Therapy in Treating Patients With Stage III or Stage IV Follicular Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: bortezomib|DRUG: cyclophosphamide|DRUG: prednisone|DRUG: vincristine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Taking Out All Teeth and Replacing Them With Dentures That Rest on Implants in People With Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus With Periodontal Complication|Inflammation|Dental Implant Failed
Interventions: PROCEDURE: Procedure/Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perineal Versus Rectal Approach for Prostate Biopsy to Prevent Iatrogenic Infections
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: PROCEDURE: Transperineal prostate biopsy|PROCEDURE: Transrectal prostate biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluate the Efficacy and Safety of Pasireotide LAR (Long Acting Release) on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma.
Status: COMPLETED
Conditions: Non-functioning Pituitary Adenoma
Interventions: DRUG: Pasireotide LAR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Azacitidine and Recombinant Interferon Alfa-2b in Treating Patients With Stage III or Stage IV Melanoma or Stage IV Kidney Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Recurrent Melanoma|Recurrent Renal Cell Cancer|Stage III Melanoma|Stage IV Melanoma|Stage IV Renal Cell Cancer
Interventions: BIOLOGICAL: recombinant interferon alfa-2b|DRUG: amifostine/azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exenatide Weekly Injections as an Adjunctive Treatment in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Chinese Herb Medicine-Moxibustion Therapy on Chemotherapy-Induced Leukopenia
Status: RECRUITING
Conditions: Cancer, Chemotherapy-induced Leukopenia, Chinese Herb Medicine-moxibustion
Interventions: OTHER: moxibustion and Chinese herbal medicine group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
Status: RECRUITING
Conditions: Trauma|Hemorrhage
Interventions: DRUG: Calcium Gluconate|DRUG: Vasopressin|DRUG: saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Impact of Multimodal Prehabilitation to Aerobic Training on Patients Undergoing Thoracoscopic Lobectomy
Status: UNKNOWN
Conditions: Perioperative|Recovery|Prehabilitation|Thoracoschisis|Lobectomy|Lung Cancer
Interventions: OTHER: Multimodal prehabilitation group|BEHAVIORAL: Aerobic training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Zonegran in the Treatment of Binge Eating Disorder Associated With Obesity
Status: COMPLETED
Conditions: Binge Eating Disorder Associated With Obesity
Interventions: DRUG: Zonegran|DRUG: sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability, Pharmacokinetic, and Pharmacodynamic Study of ALXN1920 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: BIOLOGICAL: ALXN1920|BIOLOGICAL: Placebo|BIOLOGICAL: ALXN1920|BIOLOGICAL: ALXN1920
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Eptinezumab in Adults With Migraine and Medication Overuse Headache
Status: COMPLETED
Conditions: Migraine|Medication Overuse Headache
Interventions: DRUG: Placebo|DRUG: Eptinezumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ESG401 in Adults With Solid Tumors
Status: RECRUITING
Conditions: Neoplasms, Breast|Neoplasms, Lung|Neoplasms,Colorectal|Neoplasms, Bladder|Neoplasm of Stomach|Neoplasms,Ovarian
Interventions: DRUG: ESG401
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of BMX-001 or Placebo in Head and Neck Cancer Patients
Status: WITHDRAWN
Conditions: Head and Neck Cancer
Interventions: DRUG: BMX-001|RADIATION: Radiation Therapy|DRUG: Cisplatin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Nalbuphine Versus Intravenous Dexmedetomidine for Conscious Sedation in Patients Undergoing Colonoscopy
Status: NOT_YET_RECRUITING
Conditions: Colonoscopy
Interventions: DRUG: Dexmedetomidine Injection [Precedex]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Acyclovir Therapy for Genital Herpes Ulcers in HIV Negative African Women
Status: COMPLETED
Conditions: Ulcers of Female Genital Organs
Interventions: DRUG: Acyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Retagliptin Phosphate Combined With Metformin in the Treatment of Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Retagliptin phosphate tablets、metformin sustained-release tablets|DRUG: Retagliptin phosphate placebo tablets、metformin sustained-release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maintenance Therapy of Narrow-band UV-B Therapy in Patients With Vitiligo
Status: UNKNOWN
Conditions: Phototherapy|Vitiligo|Maintenance Therapy|Narrow-band UV-B
Interventions: DEVICE: Narrow-band UV-B therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Udenafil in Patients With Erectile Dysfunction After Bilateral Nerve-sparing Radical Prostatectomy
Status: UNKNOWN
Conditions: Prostate Cancer With Radical Prostatectomy
Interventions: DRUG: ZYDENA TAB.75mg(Udenafil 75mg)|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.
Status: RECRUITING
Conditions: Rubinstein-Taybi Syndrome
Interventions: PROCEDURE: skin biopsy for the primary fibroblast culture and a 15 ml blood sample (3 unnamed samples of 5ml) in each of the 4 SRT patients included.|OTHER: Generation of Induced Pluripotent Stem Cells (iPSC) from fibroblasts obtained by skin biopsy|OTHER: Histone acetylation profiles of cells of SRT patients with CREBBP mutations|OTHER: Functional involvement of identified epigenetic alterations|BIOLOGICAL: Culture of lymphoblastoid line from blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fatty Acids Omega -3 Diet Supplementation Efficiency and Safety Evaluation in Anorexia Nervosa
Status: UNKNOWN
Conditions: Anorexia Nervosa
Interventions: DIETARY_SUPPLEMENT: fatty acids preparation- eye-q
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: INFUSE® Bone Graft and MASTERGRAFT® Granules With CD HORIZON® for Posterolateral Lumbar Fusion in Patients With Degenerative Disc Disease - Pilot Study
Status: COMPLETED
Conditions: Degenerative Disc Disease
Interventions: DEVICE: INFUSE® Bone Graft/MASTERGRAFT® Granules/CD HORIZON®|DEVICE: Autogenous Bone / CD HORIZON® Spinal System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivabradine Versus Propranolol for Induced Hypotension in Endoscopic Sinus Surgery
Status: UNKNOWN
Conditions: Hypotension
Interventions: DRUG: oral Ivabradine|DRUG: oral Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing 18F-FAPI-04 and 18F-FDG PET/CT in Cancer Detection
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: DIAGNOSTIC_TEST: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: agomelatine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asthma and Pest Control Study: Demonstrating Return-on-Investment for In-Home Pest Control for Children With Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: OTHER: Integrated Pest Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of HIFU-induced Prostate Necrosis With Shear-wave Ultrasound Elastography
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: OTHER: Shear-wave ultrasound elastography (SWUE)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Between Bupivacaine and Ropivacaine in Patients Undergoing Forearm Surgeries Under Brachial Plexus Block
Status: COMPLETED
Conditions: Effect of Drug
Interventions: PROCEDURE: Axillary Brachial plexus block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Oral Gepotidacin (GSK2140944) in Subjects With Uncomplicated Urinary Tract Infection (Acute Cystitis)
Status: COMPLETED
Conditions: Infections, Bacterial
Interventions: DRUG: Gepotidacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TQB2928 Injection Combined With Penpulimab in Treatment of Advanced Malignant Tumors.
Status: TERMINATED
Conditions: Advanced Malignant Neoplasm
Interventions: DRUG: TQB2928 injection|DRUG: Penpulimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Immune Response to Multiple Doses of PF-06881894 or US-Approved Neulasta in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: PF-06881894|BIOLOGICAL: US-approved Neulasta
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: vMII for Measurement of Oesophageal Bolus Transport and Reflux
Status: TERMINATED
Conditions: Achalasia|GORD
Interventions: PROCEDURE: Heller's Myotomy|PROCEDURE: Nissen Fundoplication|DRUG: domperidone or esomeprazole (Conservative management)|DRUG: Esomeprazole 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison of Sunlight Exposure and Vitamin D Supplementation on Serum 25-hydroxyvitamin D Levels
Status: COMPLETED
Conditions: Vitamin D Deficiency|Cardiometabolic Risk Factors
Interventions: BEHAVIORAL: Sunlight Exposure|DIETARY_SUPPLEMENT: Vitamin D Supplementation|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rollover Trial for Placebo Subjects Previously Enrolled Into GEN-003-002 Study
Status: COMPLETED
Conditions: Genital Herpes Simplex Type 2
Interventions: BIOLOGICAL: GEN-003 Vaccine (30μg of each antigen)|BIOLOGICAL: GEN-003 Vaccine (60μg of each antigen)|BIOLOGICAL: Matrix-M2 Adjuvant (25μg)|BIOLOGICAL: Matrix-M2 Adjuvant (50μg)|BIOLOGICAL: Matrix-M2 Adjuvant (75μg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Evaluation of TCI153 Probiotics for Skin Beautification
Status: RECRUITING
Conditions: Skin Condition
Interventions: DIETARY_SUPPLEMENT: Placebo sachet|DIETARY_SUPPLEMENT: TCI153 probiotic sachet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Nocardia Cell Wall Skeleton for the Treatment of Diabetic Foot Ulcer Wounds
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer|Therapy, Directly Observed
Interventions: DRUG: Nocardia rubra Cell Wall Skeleton|DRUG: Silver ions dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Silver-Coated Endotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP)
Status: COMPLETED
Conditions: Respiratory Failure
Interventions: DEVICE: silver salts coated endotracheal tube|DEVICE: uncoated endotracheal tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Talimogene Laherparepvec (T-VEC) in Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Talimogene laherparepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KD025 Hepatic Impairment Study With Normal Hepatic Function and Subjects With Varying Degrees of Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: KD025
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Ravulizumab Administered Subcutaneously With Recombinant Human Hyaluronidase PH20 (rHuPH20) in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ravulizumab|DRUG: rHuPH20
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Vaginal Misoprostol Plus Supracervical Balloon Versus Vaginal Misoprostol Alone for Induction of Labor
Status: UNKNOWN
Conditions: Induction of Labor|Cervical Ripening|Pregnancy
Interventions: DRUG: Misoprostol|DEVICE: Foley catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Ventricular Pacing Suppression Algorithms in Dual Chamber Pacemaker
Status: COMPLETED
Conditions: Sick Sinus Syndrome|Pacemaker|Heart Failure
Interventions: DEVICE: Pacemaker with Fixed long AV delay|DEVICE: Pacemaker with VpS® algorithm on|DEVICE: Pacemaker with IRSplus algorithm on
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Microbiota Directed Food for Children With Moderate Acute Malnutrition
Status: NOT_YET_RECRUITING
Conditions: Moderate Acute Malnutrition
Interventions: DIETARY_SUPPLEMENT: Microbiota-Directed Food|DIETARY_SUPPLEMENT: Ready-to-Use Supplementary Food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IH Convidecia as Second Booster Dose Against Breakthrough Infections
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH)|BIOLOGICAL: mRNA vaccine BNT162b2 (Pfizer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
Status: COMPLETED
Conditions: Head and Neck Cancer|Mucositis|Oral Complications of Radiation Therapy|Pain
Interventions: DRUG: doxepin hydrochloride|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous Invasion in Rectal Cancer (MARVEL) Trial
Status: UNKNOWN
Conditions: Adenocarcinoma|Rectal Diseases|Colorectal Neoplasms|Adenocarcinoma, Mucinous|Carcinoma|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Neoplasms|Neoplasms, Cystic, Mucinous, and Serous|Intestinal Neoplasms|Gastrointestinal Neoplasms|Digestive System Neoplasms|Neoplasms by Site|Digestive System Diseases|Gastrointestinal Diseases|Intestinal Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Armodafinil as Adjunctive Therapy in Schizophrenic Adults With Cognitive Deficits
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: armodafinil|DRUG: armodafinil|DRUG: armodafinil|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the Knee
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee|Knee Pain Chronic
Interventions: DRUG: Resiniferatoxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
Status: COMPLETED
Conditions: Lateral Canthal Lines|Crow's Feet|Facial Wrinkles
Interventions: DRUG: Botulinum Toxin Type A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sacro-hysteropexy Using Proline Mesh Versus Mersilene Tape in Apical Prolapse
Status: COMPLETED
Conditions: Apical Prolapse
Interventions: PROCEDURE: patients with apical prolapse who will do Sacro hysteropexy using mersilene tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in Neonatal Intensive Care.
Status: NOT_YET_RECRUITING
Conditions: Infection, Bacterial
Interventions: BEHAVIORAL: Optimised kangaroo care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Evaluating the Effect of Lecozotan SR on the QTc Interval
Status: COMPLETED
Conditions: Alzheimer Disease|Healthy
Interventions: DRUG: Lecozotan SR|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Stimulation to Enhance Walking Post-SCI
Status: ACTIVE_NOT_RECRUITING
Conditions: SCI - Spinal Cord Injury|Incomplete Spinal Cord Injury
Interventions: DEVICE: Soterix Medical tsDCS stimulator|OTHER: Locomotor training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial Evaluating the Effect of NN1250 at Steady State Conditions in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Arthroscopic Partial Meniscectomy Time Window
Status: WITHDRAWN
Conditions: Meniscus Lesion
Interventions: PROCEDURE: early APM|PROCEDURE: delayed APM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Automated Carbon Dioxide Angiography in Fenestrated/Branched Endovascular Abdominal Aortic Aneurysm Repair
Status: NOT_YET_RECRUITING
Conditions: Thoracoabdominal Aortic Aneurysm
Interventions: DIAGNOSTIC_TEST: CO2 angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Literacy-Adapted Psychosocial Treatments for Chronic Pain --- "Learning About Mastering/My Pain"
Status: COMPLETED
Conditions: Chronic Pain|Pain|Widespread Chronic Pain|Chronic Pain Syndrome|Chronic Pain Due to Injury
Interventions: BEHAVIORAL: Pain Ed|BEHAVIORAL: CBT for Pain|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing the Pharmacokinetics and Tolerance of D-Gam® to Rhophylac® in Rh-D-negative Healthy Volunteers.
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: D-Gam® (human anti-D immunoglobulin)|BIOLOGICAL: Rhophylac® (human anti-D immunoglobulin)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Effect of Double Duty Interventions on Double Burden of Malnutrition Among School Adolescents in Ethiopia
Status: COMPLETED
Conditions: Malnutrition; Degree, Moderate|Diet Habit|Undernutrition|Overnutrition|Underweight|Overweight
Interventions: BEHAVIORAL: Double duty interventions using nutrition behavior change communication approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations
Status: COMPLETED
Conditions: IDH1 Mutation|IDH2 Mutation|Recurrent Glioblastoma|Recurrent WHO Grade II Glioma|Recurrent WHO Grade III Glioma
Interventions: DRUG: PARP Inhibitor BGB-290|DRUG: Temozolomide|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT