pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Open-label, Dose-escalation Study to Evaluate the Pharmacokinetics of Inhaled Teicoplanin in Cystic Fibrosis Patients
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: Teicoplanin Sandoz 200 mg powder and solvent for solution for injection or infusion or oral solution.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorption, Metabolism and Excretion Study of [14C]PBT2 and Absolute Bioavailability of PBT2
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: IV PBT2 microtracer and oral PBT2 single dose|DRUG: oral 14C-PBT2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Ferrous Sulfate, Polymaltose Complex and Iron-zinc in Iron Deficiency Anemia
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferro Sanol® sp|DRUG: Santafer® sp.|DRUG: Ferro Zinc® sp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - EU/Russia Study
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: 15 mg E4/3 mg DRSP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Adenocarcinoma
Interventions: DRUG: Capecitabine|RADIATION: Radiation Therapy|DRUG: FOLFOX regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Husk Fiber Intervention on Metabolic Health of Centrally Obese School Teachers
Status: COMPLETED
Conditions: Metabolic Disease
Interventions: DIETARY_SUPPLEMENT: effect of 10 gm psyllium husk fiber twice a day, 30 minutes before breakfast and dinner|BEHAVIORAL: Effect of life style modification (Diet, Behavior and physical activity)|COMBINATION_PRODUCT: Combined effect of 10 gm Psyllium husk fiber and lifestyle modification|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Treatment of Early Stage Lung Cancer by VATS Versus OPEN Lobectomy
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: PROCEDURE: OPEN lobectomy|PROCEDURE: VATS lobectomy|DEVICE: ROBOT-assisted lobectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Four Feeding Approaches to Oral Feeding in Preterm Infants
Status: COMPLETED
Conditions: Preterm Infant
Interventions: OTHER: Early/Slow|OTHER: Early/Fast|OTHER: Late/Slow|OTHER: Late/Fast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules
Status: COMPLETED
Conditions: Dupuytren's Disease
Interventions: BIOLOGICAL: Collagenase clostridium histolyticum|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Skin Appearance Following 5-Flourouracil Cream for Treatment of Actinic Keratosis and the Effects of Topical Agents
Status: COMPLETED
Conditions: Actinic Keratoses
Interventions: DRUG: Topical Steroid Ointment|OTHER: Vaseline|DRUG: Skin Barrier Moisturier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Steady-State TMC278 on the Pharmacokinetics of a Single Dose of Digoxin
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Treatment A: Digoxin|DRUG: Treatment B: TMC278
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Watermelon Dose Response Blood Pressure Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Pre-hypertension|Cardiovascular Diseases
Interventions: OTHER: Watermelon Flesh Dose 1|OTHER: Watermelon Flesh Dose 2|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Multiple Ascending Dose Study of MEDI7247 in Patients With Selected Relapsed/Refractory Hematological Malignancies
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Multiple Myeloma|Diffuse Large B-cell Lymphoma
Interventions: DRUG: MEDI7247
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅲ Efficacy and Safety Study of Hemay005 in Subjects With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: 60mg Hemay005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Use of Allogenic Platelet Rich Plasma for the Treatment of Diabetic Foot Ulcer
Status: UNKNOWN
Conditions: Diabetic Foot Ulcer
Interventions: BIOLOGICAL: Platelet Lysate|BIOLOGICAL: Platelet Poor Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Components on Gastrointestinal Side Effects Induced by Orlistat, a Lipase Inhibitor
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Control|DIETARY_SUPPLEMENT: Capolac|DIETARY_SUPPLEMENT: Flax fiber|DIETARY_SUPPLEMENT: Capolac+Flax fiber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Next Generation Personalized Neuroblastoma Therapy
Status: TERMINATED
Conditions: Neuroblastoma|Cancer
Interventions: PROCEDURE: Biopsy|GENETIC: Next Generation Sequencing|PROCEDURE: Tumor Scans|PROCEDURE: Bone marrow Tests|OTHER: Physical Exam|OTHER: Eye Exam|OTHER: Labs|OTHER: Pregnancy Test|BEHAVIORAL: Interviews|OTHER: ECG|OTHER: Echocardiogram|DRUG: Ribociclib|DRUG: Ceritinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Establishment of Sleep Quality, Physical and Mental Health and Occupational Burnout Management Model for Shift Nursing Staff and Evaluation of Its Effectiveness
Status: UNKNOWN
Conditions: Sleep Quality|Occupational Burnout
Interventions: BEHAVIORAL: acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study for Patients With Active Rheumatoid Arthritis Despite Ongoing Methotrexate Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: LY2127399|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemotherapy and Anti-PD-1 Antibody in Patients With Stage IIIC2-IVB Cervical Cancer
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Arm, Tolerability and Safety Phase IV Study of Fulvestrant(Faslodex® ) as 2nd Line and Later Therapy in Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Locally Advanced or|Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Knee Degenerative Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis
Interventions: DEVICE: Transcatheter Arterial Micro-Embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mulligan Mobilizations Versus Active Release Technique in Tension-type Headache.
Status: NOT_YET_RECRUITING
Conditions: Tension-Type Headache
Interventions: OTHER: Mulligan mobilizations|OTHER: Active Release Technique|OTHER: Mulligan mobilizations with active release technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study on the Strategy of HSV-Tk Engineering Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia
Status: TERMINATED
Conditions: Acute Leukemia (Category)
Interventions: GENETIC: HSV-Tk|OTHER: T-cell depleted or T-cell replete strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Afrezza® INHALE-1 Study in Pediatrics
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: BIOLOGICAL: Afrezza|BIOLOGICAL: Rapid-acting Insulin Analog|BIOLOGICAL: Basal Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SprmPik AI Sperm Selection Study SiD, an Assistant for Sperm Selection During Intracytoplasmic Sperm Injection in Medically Assisted Reproduction: Effect on Fertilization, Blastocyst Formation, Early Pregnancy Loss, and Consistent Practice. A Prospective Pilot Study.
Status: RECRUITING
Conditions: Infertility
Interventions: OTHER: Artificial Intelligence assisted sperm selection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Combination Therapy With Nivolumab and PD-L1/IDO Peptide Vaccine to Patients With Metastatic Melanoma
Status: UNKNOWN
Conditions: Metastatic Melanoma
Interventions: DRUG: Nivolumab|BIOLOGICAL: PD-L1/IDO peptide vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: Resistance Exercise|OTHER: Endurance Exercise|OTHER: Stretching/Range-of-Motion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bevacizumab, Gemcitabine, and Oxaliplatin in Treating Patients With Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: bevacizumab|DRUG: gemcitabine hydrochloride|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intensified Dosing of Cellcept (Mycophenolate Mofetil) in Kidney Transplantation
Status: COMPLETED
Conditions: Acute Rejection of Renal Transplant
Interventions: DRUG: mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Open-label Study, to Evaluate the Safety and Tolerability of Zoledronic Acid in Patients With Bone Lesions Secondary to Multiple Myeloma.
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: DRUG: Zoledronic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ISIS 183750 With Irinotecan for Advanced Solid Tumors or Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Neoplasms|Colorectal Carcinoma|Colorectal Tumors
Interventions: DRUG: ISIS 183750|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Rosuvastatin on Cytokines After Traumatic Brain Injury
Status: COMPLETED
Conditions: Head Injury
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effect of Sexuality-Based Family Planning Education Given to Women Via Podcast on Contraceptive Method Selection and Sexual Life Quality
Status: RECRUITING
Conditions: Contraception
Interventions: BEHAVIORAL: Sexuality-Based Family Planning Education via Podcast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis?
Status: COMPLETED
Conditions: Postpartum Endometritis
Interventions: DRUG: povidone- iodine solution.|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Reversal of Aspirin Antiplatelet Therapy With Cold Stored Platelets
Status: UNKNOWN
Conditions: Reversal of Platelet Aggregation Inhibitors
Interventions: BIOLOGICAL: Autologous Room Temperature stored Platelet transfusion|BIOLOGICAL: Autologous Cold Stored Platelet transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Two Radiological Modalities, Ultrasonography Versus Stress Radiography, in the Urgent Care and Prognosis of Lateral Ankle Sprain (TALOS)
Status: COMPLETED
Conditions: Lateral Ankle Sprain
Interventions: OTHER: Ankle echography|OTHER: Ankle echography + stress radiography|OTHER: stress radiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Motivational Interviewing in the Management of Non Alcoholic Fatty Liver Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: BEHAVIORAL: Motivational Interview|BEHAVIORAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ARC-520 in Participants With Hepatitis B Virus e Antigen (HBeAg) Positive Chronic Hepatitis B Virus
Status: TERMINATED
Conditions: Chronic Hepatitis B
Interventions: DRUG: ARC-520|DRUG: Placebo|DRUG: Entecavir|DRUG: Tenofovir|DRUG: diphenhydramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Study of the Safety and Efficacy of Cl-108 in the Treatment of Moderate to Severe Pain
Status: COMPLETED
Conditions: Pain|Nausea|Vomiting
Interventions: DRUG: CL-108 (hydrodocone 7.5 mg, acetaminophen 325 mg, promethazine 12.5 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Oryza Sativa l Extract to LPS, ZO-1, and Intestinal Microbiota in Obese Individuals
Status: UNKNOWN
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Oryza Sativa Extract|DIETARY_SUPPLEMENT: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of PAD Versus Velcade, Cyclophosphamide and Dexamethasone (VCD) Treatment in Subjects With Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: PAD|DRUG: VCD|OTHER: ASCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Probiotics on Infections in Cirrhosis
Status: COMPLETED
Conditions: Liver Cirrhosis
Interventions: DIETARY_SUPPLEMENT: Winclove-849|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer
Status: COMPLETED
Conditions: Islet Cell Adenoma|Zollinger Ellison Syndrome
Interventions: DRUG: Interferon
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Implant Primary Stability and Ridge Dimensional Changes Utilizing the Osseodensification Protocol
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Implants
Interventions: DEVICE: OsseoDensification (OD) protocol|DEVICE: standard drilling (SD) protocol (NobelReplace® Conical)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Physiological and Perceptual Responses to Novel Forms of High-intensity Interval Exercise
Status: COMPLETED
Conditions: High-intensity Interval Exercise|Heart Rate|Rating of Perceived Exertion|Blood Pressure|Acute Mood|Physical Activity Enjoyment
Interventions: BEHAVIORAL: Boxing|BEHAVIORAL: Stair stepping|BEHAVIORAL: Stair climbing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Narrow-Band Imaging Versus Standard White Light for the Detection of Serrated Lesions in the Proximal Colon
Status: COMPLETED
Conditions: Colon Cancer
Interventions: PROCEDURE: Inspection with Narrow-Band Imaging(NBI)|PROCEDURE: Standard White Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multiple Dose Pharmacokinetics of LCZ696 and Its Metabolites in Subjects With Severe Renal Impairment vs. Matched Healthy Subjects With Normal Renal Function
Status: COMPLETED
Conditions: Pharmacokinetics|Renal Impaired|Healthy Volunteer
Interventions: DRUG: LCZ696A|DRUG: LCZ696A
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotics on Synaptic Plasticity During the Menstrual Cycle
Status: NOT_YET_RECRUITING
Conditions: Women's Health|Brain Plasticity
Interventions: BIOLOGICAL: Progressive Perfect Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Geko™ Plaster Cast Study, Deep Vein Thrombosis (DVT) Prophylaxis
Status: COMPLETED
Conditions: Deep Vein Thrombosis
Interventions: DEVICE: geko|DEVICE: Plaster cast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Immunogenicity and Safety of V-01-351/V-01D Bivalence Vaccine
Status: UNKNOWN
Conditions: COVID-19 Pandemic
Interventions: BIOLOGICAL: Recombinant SARS-CoV-2 Beta Variant Fusion Protein Vaccine/Recombinant SARS-CoV-2 Delta Variant Fusion Protein Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Immune Deficiency Patients Treated With Subcutaneous Immunoglobulin (IgPro20, Hizentra®) on Weekly and Biweekly Schedules
Status: COMPLETED
Conditions: Primary Immune Deficiency|Secondary Immune Deficiency
Interventions: BIOLOGICAL: Subcutaneous Immune Globulin (Human) (Hizentra)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Adaptive Support Ventilation in Acute Respiratory Distress Syndrome (ARDS)
Status: UNKNOWN
Conditions: Respiration, Artificial|Respiratory Distress Syndrome, Adult
Interventions: PROCEDURE: type of mechanical ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Honey on Lessening the Withdrawal Symptoms
Status: UNKNOWN
Conditions: Smoking Cessation|Withdrawal Symptoms
Interventions: DIETARY_SUPPLEMENT: Honey|DIETARY_SUPPLEMENT: Water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Dual Therapy Hasten Antidepressant Response?
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: escitalopram|DRUG: bupropion extra long (XL)|DRUG: escitalopram + bupropion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Neuromuscular Electrical Stimulation
Status: COMPLETED
Conditions: Postoperative Coronary Artery Bypass Grafting (CABG)|Chronic Obstructive Pulmonary Disease (COPD)|Ventilatory Failure
Interventions: DEVICE: ELECTRICAL STIMULATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Plecanatide Comparing With Placebo in the Treatment of Functional Constipation
Status: COMPLETED
Conditions: Functional Constipation
Interventions: DRUG: Plecanatide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mitomycin C on Urethral Stricture Recurrence After Internal Urethrotomy
Status: UNKNOWN
Conditions: Urethral Stricture
Interventions: PROCEDURE: Internal urethrotomy|DRUG: Mitomycin C - local injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic (PK) Bioequivalence and Pharmacodynamics (PD) of Julphar Insulin 30/70 and Huminsulin® Profil III
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: human biphasic insulin|DRUG: human biphasic insulin, reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Evaluation of Probiotic in the Clinical Course of Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DIETARY_SUPPLEMENT: Probiotic|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Mechanisms of Technology-based Behavioral Interventions
Status: UNKNOWN
Conditions: College Student Drinking
Interventions: BEHAVIORAL: college drinker's check up|BEHAVIORAL: Protective Behavioral Strategies Intervention|BEHAVIORAL: Ecological Momentary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Occlusal Versus Apical Bent Wires in Patients on Erich Arch Bar
Status: NOT_YET_RECRUITING
Conditions: Maxillofacial Injuries
Interventions: DEVICE: Ending of the wires on Erich arch bar in the occlusal direction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Delirium Reduction With Ramelteon
Status: RECRUITING
Conditions: Delirium
Interventions: DRUG: Ramelteon 8mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asthma, a Disease Due to a Lack of Bacterial Infections in Childhood.
Status: COMPLETED
Conditions: Food Allergy|Atopic Dermatitis|Asthma|Rhinitis
Interventions: BIOLOGICAL: BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: LLTS to Treat Premature Ventricular Contractions
Status: UNKNOWN
Conditions: Premature Ventricular Contraction
Interventions: DEVICE: Low-level tragus stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fasting Conditions in Healthy Volunteers
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: BR1015|DRUG: BR1015-1|DRUG: BR1015-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nourishing Hair, Skin & Nails Supplement Study (Derm Aid)
Status: COMPLETED
Conditions: Hair Loss|Skin Laxity|Cosmetic Acne|Nails; Soft|Skin Aging
Interventions: DIETARY_SUPPLEMENT: Vegetarian Collagen|DIETARY_SUPPLEMENT: Keratin|DIETARY_SUPPLEMENT: Ceramides|DIETARY_SUPPLEMENT: Astaxanthin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery
Status: UNKNOWN
Conditions: High-risk Prostate Cancer|Prostate Cancer
Interventions: DRUG: HSV-Tk|DRUG: Valacyclovir|DRUG: Bicalutamide|DRUG: Leuprolide Acetate|RADIATION: Brachytherapy, External beam radiotherapy|PROCEDURE: Radical prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pivotal Study of Sebacia Microparticles in the Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Inflammatory Acne Vulgaris
Interventions: DEVICE: Sebacia microparticles and laser|DEVICE: Vehicle suspension and laser|DEVICE: Sebacia microparticles without laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype
Status: RECRUITING
Conditions: Multiple Sclerosis|Sleep|Pain
Interventions: DRUG: Cannabidiol (CBD)|DRUG: Tetrahydrocannabinol (THC)|DRUG: Placebo CBD|DRUG: Placebo THC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase III Clinical Study to Evaluate the Efficacy and Safety of the Combination of Lercanidipine/Valsartan in Hypertensive Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Lercanidipine 10mg|DRUG: Lercanidipine10mg /Valsartan 80mg|DRUG: Lercanidipine 10mg /Valsartan 160mg|DRUG: Lercanidipin 10mg Placebo|DRUG: Lercanidipine10mg /Valsartan 80mg Placebo|DRUG: Lercanidipine 10mg /Valsartan 160mg Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simvastatin Effect on the Incidence of Acute Lung Injury/Adult Respiratory Distress Syndrome (ALI/ARDS)
Status: WITHDRAWN
Conditions: Adult Respiratory Distress Syndrome|Acute Lung Injury
Interventions: DRUG: Simvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tailored Regimens of PEGASYS® and Ribavirin for Genotype 1 Chronic Hepatitis C Patients Trial (TARGET-1)
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: A: Peg-interferon alpha-2a & Ribavirin|DRUG: B: Peg-interferon alpha-2a & Ribavirin|DRUG: C: Peg-interferon alpha-2a & Ribavirin|DRUG: D: Peg-interferon alpha-2a & Ribavirin|DRUG: E: Peg-interferon alpha-2a & Ribavirin|DRUG: F: Peg-interferon alpha-2a & Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bicarbonate vs Heparin Catheter Lock in Chronic Hemodialysis Patients
Status: UNKNOWN
Conditions: End Stage Renal Disease|Vascular Access Complication|Catheter Complications|Hemodialysis Access Failure|Hemodialysis Catheter Infection
Interventions: DRUG: Sodium Bicarbonate 7.5% Injection|DRUG: Heparin Sodium, 1000 Units/mL Injectable Solution 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dose Range Finding Study of BF2.649 Versus Placebo to Treat Excessive Daytime Sleepiness in Parkinson's Disease Patients
Status: COMPLETED
Conditions: Excessive Daytime Sleepiness|Parkinson's Disease
Interventions: DRUG: Placebo|DRUG: BF 2.649 5 mg|DRUG: BF 2.649 10 mg|DRUG: BF 2.649 20 mg|DRUG: BF 2.649 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Veliparib in Combination With Carboplatin and Paclitaxel in Japanese Subjects With Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: veliparib (ABT-888)|DRUG: carboplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Tirofiban and the Paclitaxel Eluting Stent in Postfibrinolysis Angioplasty
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: PROCEDURE: Postfibrinolysis percutaneous coronary intervention|PROCEDURE: Postfibrinolysis percutaneous coronary intervention|PROCEDURE: Postfibrinolysis percutaneous coronary intervention|PROCEDURE: Postfibrinolysis percutaneous coronary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Satiation Measures on the Portion Size Effect
Status: COMPLETED
Conditions: Feeding Behavior
Interventions: OTHER: 100% portion size|OTHER: 125% portion size|OTHER: 150% portion size|OTHER: 175% portion size
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety Study of ON 01910.Na in Combination With Irinotecan or Oxaliplatin
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: ON 01910.Na and irinotecan|DRUG: ON 01910.Na and oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metformin-Docetaxel Association in Metastatic Hormone-refractory Prostate Cancer
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: METFORMIN|DRUG: Placebo|DRUG: TAXOTERE®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery
Status: COMPLETED
Conditions: Total Knee Replacement|Total Hip Replacement
Interventions: DRUG: LY517717|DRUG: enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Safety and Efficacy Study for Infliximab (Remicade) With Methotrexate in Patients With Early Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of an Anti-cancer Immunotherapy Combined With Standard Neoadjuvant Treatment in Patients With WT1-positive Primary Invasive Breast Cancer
Status: TERMINATED
Conditions: Neoplasms, Breast
Interventions: BIOLOGICAL: GSK Biologicals' recombinant WT1 Antigen-Specific Cancer Immunotherapeutic (ASCI) GSK2302024A|DRUG: Placebo|DRUG: Aromatase inhibitor|DRUG: 5-Fluorouracil|DRUG: Carboplatin AUC|DRUG: Cyclophosphamide|DRUG: Docetaxel|DRUG: Doxorubicin|DRUG: Epirubicin|DRUG: Paclitaxel|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AGEN1571 in Participants With Advanced Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor
Interventions: DRUG: AGEN1571|DRUG: Balstilimab|DRUG: Botensilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: DRUG: Gemcitabine|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Impact Study of Aquatabs in Tamale, Ghana
Status: COMPLETED
Conditions: Diarrhea
Interventions: OTHER: Sodium dichloroisocyanurate (NaDCC) tablets|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of SHJ002 Sterile Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: SHJ002/Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of IN-C006 Peri Inj. Compared With RPN301
Status: COMPLETED
Conditions: Parenteral Nutrition
Interventions: DRUG: IN-C006 Peri inj.|DRUG: RPN301
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of an add-on Treatment With Zonisamide in Adults With Focal Epileptic Seizures With or Without Secondary Generalization
Status: TERMINATED
Conditions: Epilepsy
Interventions: DRUG: Zonegran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addition of Paclitaxel to High-Dose Combination Chemotherapy in Treating Women With Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: mesna|DRUG: paclitaxel|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Effect of Branebrutinib on the Drug Levels of Rosuvastatin in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Rosuvastatin|DRUG: Branebrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oxytocin Treatment of Opioid Dependence
Status: COMPLETED
Conditions: Opioid Dependence|Opioid Withdrawal
Interventions: DRUG: Intranasal Oxytocin Spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examination of Psychological Tools and Tracking in an Online Intervention for Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: diet and lifestyle program|BEHAVIORAL: positive affect informational materials|BEHAVIORAL: mindfulness informational materials|BEHAVIORAL: dietary tracking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HS219 in Chronic Kidney Disease Patients on Hemodialysis With Hyperphosphatemia
Status: COMPLETED
Conditions: Hyperphosphatemia|Chronic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: HS219|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interest of Ultrasound Coupled to a Guidance System (GPS) for Central Venous Catheters (CVC) Insertion.
Status: COMPLETED
Conditions: Surgery
Interventions: DEVICE: Use of ultrasound with active GPS|DEVICE: Use of ultrasound with inactive GPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Psycho-education Intervention for Postpartum OCD and it's Influence on Symptom Severity and Treatment Self Referral Rates
Status: UNKNOWN
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: psycho-education pamphlet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Preeclampsia With Aspirin in Recipients of Donated Oocytes.
Status: TERMINATED
Conditions: Pre-Eclampsia
Interventions: DRUG: Acetylsalicylic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of the Use of Dry Needling in Conventional Non-invasive Treatment of Acute and Subacute Whiplash
Status: COMPLETED
Conditions: Whiplash Injuries
Interventions: OTHER: Motor Control|OTHER: Manual Therapy|OTHER: Dry Needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: One Year Clinical Evaluation of E-max CAD and Lava Ultimate Laminate Veneers
Status: UNKNOWN
Conditions: Discoloration, Tooth
Interventions: OTHER: lava ultimate|OTHER: E.max cad
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects
Status: COMPLETED
Conditions: Dry Eye
Interventions: OTHER: Propylene glycol 0.6% ocular emulsion|OTHER: Sodium chloride 0.9% saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low-level Light Therapy for Overactive Bladder and Urinary Incontinence
Status: UNKNOWN
Conditions: Overactive Bladder|Urinary Incontinence
Interventions: DEVICE: Low-level light therapy|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP)
Status: COMPLETED
Conditions: High-grade Glioma|Astrocytoma|Glioblastoma
Interventions: RADIATION: 18F Fluorothymidine PET CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Nilotinib in Adult Patients With Gastrointestinal Stromal Tumors Resistant to Imatinib and Sunitinib.
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Urinary Biomarkers for AKI Diagnosis in Patients With SARS-CoV-2 (COVID-19)
Status: COMPLETED
Conditions: COVID-19|Renal Replacement Therapy|Acute Kidney Injury
Interventions: OTHER: [TIMP-2]*[IGFBP-7]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers
Status: COMPLETED
Conditions: Cervical Cancer|Oropharyngeal Cancer|Vaginal Cancer|Anal Cancer|Penile Cancer
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Young TIL|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy of the MyoTrain System in a Population of Individuals With Trans-radial Limb Loss
Status: RECRUITING
Conditions: Amputation|Upper Limb
Interventions: DEVICE: MyoTrain|BEHAVIORAL: Motor Imagery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Mackenzie Extension and William Flexion Exercises in Lumbo-sarcal Radiculopathy
Status: COMPLETED
Conditions: Lumbosacral Radiculopathy
Interventions: OTHER: Mckenzie Extension Exercises|OTHER: William Flexion Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Function in Older Women With Stage I, Stage II, or Stage III Breast Cancer Receiving Hormone Therapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: letrozole|OTHER: questionnaire administration|PROCEDURE: cognitive assessment|PROCEDURE: psychosocial assessment and care
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Assess the Bioequivalence of Fixed Dose Combination (FDC) Tablets of Canagliflozin and Metformin Immediate Release (IR) With Respect to the Individual Components of Canagliflozin and Metformin IR Tablets in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: A (canagliflozin and metformin IR individual tablets) / B (canagliflozin/metformin IR FDC tablets)|DRUG: B (canagliflozin/metformin IR FDC tablets / A (canagliflozin and metformin IR individual tablets)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sedation and Analgesia Using PFK Versus General Anesthesia in Urological Procedures
Status: COMPLETED
Conditions: Anesthesia|Urologic Diseases
Interventions: DRUG: General anesthetia Fentanyl and Propofol|COMBINATION_PRODUCT: PFK
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: LM-108 in Combination With PD-1 Based Treatment for Patients With Recurrent or Metastatic Triple - Negative Breast Cancer
Status: RECRUITING
Conditions: TNBC - Triple-Negative Breast Cancer
Interventions: DRUG: LM-108|DRUG: Toripalimab|DRUG: Eribulin|DRUG: Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementation With Lacobacillus Reuteri ATCC PTA 4659 in Patients Affected by Acute Uncomplicated Diverticulitis
Status: COMPLETED
Conditions: Acute Diverticulitis
Interventions: DIETARY_SUPPLEMENT: Lactobacillus Reuteri 4659|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cells in Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Granulocyte Colony Stimulating Factor G-CSF (Neupogen®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Chemoradiation for Locally Advanced and Low Rectal Cancers: Avastin-Capecitabine-Oxaliplatin-Radiation REctal Cancer Trial
Status: COMPLETED
Conditions: Advanced Colorectal Cancer
Interventions: DRUG: Bevacizumab:
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Ropivacaine|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CCI-779 in Treating Patients With Recurrent Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma|Recurrent Adult Brain Tumor
Interventions: DRUG: temsirolimus|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope
Status: COMPLETED
Conditions: Neuromediated Cardioinhibitory Syncope
Interventions: PROCEDURE: transcatheter ablation of ganglionated plexi in right atrium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Choline and Docosahexaenoic Acid Supplementation in Preterm Infants
Status: COMPLETED
Conditions: Infant, Premature
Interventions: DIETARY_SUPPLEMENT: choline supplementation|DIETARY_SUPPLEMENT: DHA supplementation|DIETARY_SUPPLEMENT: standard nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION