pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Axis(TM) Solvent-dehydrate Dermal Allograft in the Treatment of Pelvic Organ Prolapse.
Status: ACTIVE_NOT_RECRUITING
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: Axis Dermis biologic mesh repair for pelvic organ prolapse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tislelizumab (BGB-A317) as Neo-Adjuvant Treatment in Patients With Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: Azeliragon|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate Tolerability and Safety of ARK-E021 Foam and to Monitor Clinical Effect in Acne Vulgaris Patients
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: ARK-E021 5%|DRUG: ARK-E021 10%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Pharmacokinetics of TPOXX® When Administered Orally for 28 Days With JYNNEOS
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: JYNNEOS + TPOXX|BIOLOGICAL: JYNNEOS + TPOXX PLACEBO
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Salbutamol, Pharmacogenetics and Breathing Mechanics
Status: COMPLETED
Conditions: Bronchoconstriction|Inhaled Salbutamol|Cycling Performance
Interventions: DRUG: Salbutamol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes
Status: RECRUITING
Conditions: Schizophrenia; Psychosis|First Episode Psychosis|Clinical High Risk
Interventions: DEVICE: repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Artificial Saliva Spray Reduces Xerostomia in Diabetes Type II
Status: COMPLETED
Conditions: Xerostomia Due to Hyposecretion of Salivary Gland|Diabetes Mellitus, Type 2
Interventions: DEVICE: artificial saliva spray (AS)|OTHER: maritime throat spray (TT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Intranasal Oxytocin on Dysphagia in Children and Adolescents With Prader-Willi Syndrome
Status: COMPLETED
Conditions: Prader-Willi Syndrome
Interventions: DRUG: Oxytocin nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Phase 1b Open-label Study to Evaluate the Safety and Efficacy of CC-122 With Obinutuzumab (GA101) in Relapsed/Refractory DLBCL and iNHL.
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse|Lymphoma, Non-Hodgkin
Interventions: DRUG: Obinutuzumab|DRUG: CC-122
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)
Status: RECRUITING
Conditions: Hormone Receptor Positive Breast Cancer|Triple Negative Breast Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Datopotamab Deruxtecan (Dato-DXd)|DRUG: Steroid Containing Mouthwash|OTHER: Non-Steroid Containing Mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment
Status: COMPLETED
Conditions: Essential Hypertension|Cardiovascular Disease|Stroke|Chronic Kidney Disease
Interventions: DRUG: Any antihypertensive medication alone or in combination|DRUG: Any antihypertensive medication alone or in combination|DEVICE: Ambulatory blood pressure monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Palovarotene for the Treatment of MO
Status: TERMINATED
Conditions: Exostoses, Multiple Hereditary
Interventions: DRUG: Palovarotene 2.5 mg|DRUG: Palovarotene 5.0 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Latanoprostene Bunod in Lowering Intraocular Pressure in Japanese Healthy Male Volunteers
Status: COMPLETED
Conditions: Intraocular Pressure
Interventions: DRUG: Latanoprostene bunod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Statseal® for Central Venous Catheter Insertion Sites in Critical Care
Status: NOT_YET_RECRUITING
Conditions: Central Line|Central Venous Catheter|Vascular Access|Critical Care|Hemostatic
Interventions: OTHER: A haemostatic mineral powder product.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Metadoxine SR Formulation in Attention Deficit Hyperactivity Disorder (ADHD) Subjects
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Extended Release Metadoxine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Optimal Control of Pre-operative Chronic and Acute Pain Predict Improved Function After Orthopedic Surgery?
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Pregabalin, Celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Low Dose PK-guided EHL FVIII Concentrates Versus Standard Prophylaxis in Severe Haemophilia A
Status: COMPLETED
Conditions: Severe Hemophilia A Without Inhibitor
Interventions: DRUG: Extended half-life FVIII concentrates with PK-guided dosing|DRUG: standard half-life FVIII concentrates with weight-based dosing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Text Messaging-Based Smoking Cessation Program for Homeless Youth
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: BEHAVIORAL: Group counseling and nicotine replacement|BEHAVIORAL: Group counseling, nicotine replacement, and text messaging support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: PROCEDURE: Bone Marrow Transplant (BMT)|DRUG: Hydroxyurea|DRUG: Thiotepa|DRUG: Fludarabine monophosphate|DRUG: Cyclophosphamide|OTHER: Rabbit Anti-thymocyte Globulin|RADIATION: Total Body Irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Assess the Safety and Efficacy of the 4 Channel NMES Compensatory Medical Device in Swallowing, Multicenter Study
Status: COMPLETED
Conditions: Dysphagia
Interventions: DEVICE: 4 channel Electrical Stimulation Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Camrelizumab Plus Amlotinib and Chemotherapy in the First-line Treatment of Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: Camrelizumab|DRUG: Anlotinib|DRUG: nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Docetaxel in Treating Patients With Refractory or Recurrent Advanced Gynecologic Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Endometrial Cancer|Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cavity Cancer|Sarcoma|Vaginal Cancer|Vulvar Cancer
Interventions: DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Mucogyne® Ovule in Vulvovaginal Dryness Management in Women Treated by Brachytherapy and/or Radiotherapy for Endometrial or Cervical Cancer.
Status: UNKNOWN
Conditions: Vaginal Disease
Interventions: DEVICE: Mucogyne® ovule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ledipasvir/Sofosbuvir Fixed-Dose Combination on Cerebral Metabolism and Neurocognition in Treatment-Naive and Treatment-Experienced Participants With Chronic Genotype 1 HCV Infection
Status: COMPLETED
Conditions: Hepatitis C Virus Infection
Interventions: DRUG: LDV/SOF|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Memory-Updating Technique to Reduce Food Craving and High Calorie Food Intake Among Individuals With Overweight/Obesity
Status: WITHDRAWN
Conditions: Overweight|Obesity|Craving|Eating Behavior
Interventions: BEHAVIORAL: Retrieval-extinction (R-E) Training|BEHAVIORAL: Extinction Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colorectal Cancer With Liver-limited Synchronous Metastases: an Inception Cohort Study of Standardised Care Pathways
Status: COMPLETED
Conditions: Colorectal Neoplasms|Liver Neoplasms|Neoplasm Metastasis
Interventions: PROCEDURE: Primary/Bowel-first Surgery|PROCEDURE: Liver-first surgery|PROCEDURE: Synchronous resection surgery|PROCEDURE: No surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Synera™ for Epidural Needle Insertion
Status: COMPLETED
Conditions: Pain Associated With Epidural Needle Insertion
Interventions: DRUG: Synera(TM)|OTHER: Placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Adhesion of Connective Tissue Around Laser-treated Abutments for Dental Implants - Clinical Trial in Humans
Status: UNKNOWN
Conditions: Periimplantitis
Interventions: PROCEDURE: Dental implant placement with a final prosthetic abutment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Label Study Assessing Effectiveness Of Amlodipine/Atorvastatin In Subjects With Hypertension and Dyslipidaemia
Status: COMPLETED
Conditions: Hypertension|Dyslipidemia
Interventions: DRUG: Amlodipine/Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Non-invasive Respiratory Monitoring System (RMS) to Capnography for Respiratory Rate (RR)
Status: COMPLETED
Conditions: Respiratory Monitoring
Interventions: DEVICE: Makani Science Respiratory Monitoring System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Pilot Investigation of Clinician-guided Internet-Delivered Cognitive Behavioural Therapy for Depressed Patients
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: BEHAVIORAL: Internet-delivered Cognitive Behavioural Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraoperative Pain After Infiltration Technique Using Artpharma Versus Artinibsa in Children
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: OTHER: Artpharma|OTHER: Artinibsa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole
Status: WITHDRAWN
Conditions: Refractory Reflux Esophagitis
Interventions: DRUG: Trimebutine Maleate|DRUG: rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tiotropium + Procaterol vs Tiotropium + Placebo in COPD Patients
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Procaterol|DRUG: Tiotropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Double-Blind, Placebo-Controlled Study of Two Doses of EPA-E in Patients With Non Alcoholic Steatohepatitis (NASH)
Status: COMPLETED
Conditions: Steatohepatitis
Interventions: DRUG: Placebo capsule|DRUG: EPA-E 300 mg capsule|DRUG: EPA-E 300 mg capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of CKD-495 Tablet
Status: COMPLETED
Conditions: Gastritis
Interventions: DRUG: CKD-495 75mg|DRUG: CKD-495 150mg|DRUG: Artemisiae argyi folium 95% ethanol ext.(20→1) 60mg|DRUG: Rebamipide 100mg|DRUG: Placebo of the CKD-495 75mg|DRUG: Placebo of the CKD-495 150mg|DRUG: Placebo of Artemisia Herb 95% Ethanol Soft Ext.(20→1) 60mg|DRUG: Placebo of the Rebamipide 100mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Transplantation Using CD34-Selected Stem Cells From Related or Unrelated Donors in Treating Participants With Cancer or Other Disorders
Status: AVAILABLE
Conditions: Benign Neoplasm|Bone Marrow Transplantation Recipient|Hematopoietic Cell Transplantation Recipient|Malignant Neoplasm
Interventions: PROCEDURE: Bone Marrow Transplantation|DEVICE: CliniMACS CD34 Reagent System|PROCEDURE: Peripheral Blood Stem Cell Transplantation
Study Type: EXPANDED_ACCESS
Clinical trial: Effects of Low Frequency TENS and Therapeutic Ultrasound in Post-stroke Shoulder Pain
Status: RECRUITING
Conditions: Stroke|Shoulder Pain
Interventions: OTHER: low frequency transcutaneous electrical stimulation and Therapeutic Ultrasound|OTHER: Therapeutic Ultrasound|OTHER: Low frequency transcutaneous electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Dopaminergic Modulation of Frontostriatal Function With a Dopamine Agonist and COMT Inhibitor
Status: WITHDRAWN
Conditions: Addiction
Interventions: DRUG: Tolcapone|DRUG: Placebo|DRUG: Bromocriptine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexamethasone Versus Burr Hole Craniostomy for Symptomatic Chronic Subdural Hematoma
Status: TERMINATED
Conditions: Chronic Subdural Hematoma
Interventions: DRUG: Dexamethasone|PROCEDURE: Burr Hole Craniostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Dedicated Venous Sinus Thrombectomy Stent for Endovascular Treatment of Cerebral Venous Sinus Thrombosis.
Status: UNKNOWN
Conditions: Cerebral Venous Sinus Thrombosis
Interventions: DEVICE: the dedicated venous sinus thrombectomy stent|DEVICE: balloon catheter thrombectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD
Status: UNKNOWN
Conditions: Renal Anemia|Iron Toxicity|Oxidative Stress|Endothelial Dysfunction
Interventions: DRUG: Sodium Chloride 0.9% Intravenous Solution|DRUG: Ferinject
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I 2-Way Crossover Study to Assess Relative BA of Tablet Versus Liquid Suspension and Food Effect on Tablet Formulation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: AZD2624|DRUG: AZD2624
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Potassium Intake in Patients With Chronic Kidney Disease
Status: COMPLETED
Conditions: Chronic Kidney Disease|Hypertension
Interventions: OTHER: Dietary intake of potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6
Status: ACTIVE_NOT_RECRUITING
Conditions: GBM|Glioblastoma|Brain Tumor|Brain Tumor, Recurrent
Interventions: DRUG: Abemaciclib|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy)
Status: RECRUITING
Conditions: HNSCC
Interventions: DRUG: Cisplatin|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis
Status: COMPLETED
Conditions: Herpes Labialis
Interventions: DRUG: Squaric Acid solution|DRUG: Placebo solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Real-World Clinical Study on the Efficacy of Vibrating Capsule (Vibrabot Capsule) for Chronic Functional Constipation
Status: NOT_YET_RECRUITING
Conditions: Clinical Study|Chronic Functional Constipation
Interventions: DEVICE: Treatment with Vibrating Capsule
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Manual Hyperinflation and Physical Therapy Program on Lung Recruitment Mechanically Ventilated Pediatric Patients
Status: COMPLETED
Conditions: Mechanical Ventilation Complication|Physical Disability
Interventions: DEVICE: rehabilitation of mechanically ventilated patients|PROCEDURE: supportive care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: taVNS-Paired Breastfeeding to Improve Breastfeeding at Discharge
Status: RECRUITING
Conditions: Premature Birth|Breastfeeding, Exclusive|Feeding; Difficult, Newborn
Interventions: DEVICE: taVNS soterix device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate
Status: COMPLETED
Conditions: Clomiphene Citrate Resistant Polycystic Ovary Syndrome
Interventions: DIETARY_SUPPLEMENT: vitamin E|DRUG: Metformin|DRUG: Clomiphene Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Lower Limb Nerve Blocks in Postoperative Analgesia for the Free Flap Donor Sites
Status: RECRUITING
Conditions: Elective Reconstructive Surgery|Pain, Post Operative
Interventions: PROCEDURE: femoral nerve block, common peroneal nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of the Rate of Preoperative Haemoglobin After Administration of Epoetin Alpha Associated With an Oral Medical Supplementation Versus Intravenous Before Surgery of Craniosynostosis at the Child
Status: RECRUITING
Conditions: Craniosynostosis
Interventions: DRUG: Ferrous fumarate or ferrostrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Probiotics on Obesity. Metabolic Endotoxemia and Inflammation
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Probiotane|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital Hyperinsulinism
Status: COMPLETED
Conditions: Congenital Hyperinsulinism
Interventions: DRUG: Cohort 1|DRUG: Cohort 2|DRUG: Cohort 3|DRUG: Cohort 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KW-136 With Sofosbuvir for Chinese Adults With Chronic Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: KW-136 capsule|DRUG: Sofosbuvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Accurate Clinical Study of Medication in Patients With Depression Via Pharmacogenomics (PGx) and Therapeutic Drug Monitoring (TDM) of Venlafaxine
Status: UNKNOWN
Conditions: Depression
Interventions: DIAGNOSTIC_TEST: pharmacogenomics|DIAGNOSTIC_TEST: pharmacogenomics & therapeutic drug monitoring|DRUG: Venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Pressure Ulcer Prevention Programme for Older People in For-profit Private Nursing Homes
Status: COMPLETED
Conditions: Prevention of Pressure Ulcers
Interventions: BEHAVIORAL: PU prevention programme|BEHAVIORAL: Usual PU prevention care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Feasibility of Web-based CBT-I Intervention in Individuals With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Cognitive behavioral therapy for insomnia|BEHAVIORAL: Cognitive behavioral therapy for insomnia + biweekly support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability of Two Fixed Dose Combination (FDC) Formulations of Dutasteride and Tamsulosin Hydrochloride Relative to Co-administration of Dutasteride With Tamsulosin Hydrochloride in Healthy Male Subjects Under Fed and Fasted States
Status: COMPLETED
Conditions: Prostatic Hyperplasia
Interventions: DRUG: Treatment sequence A|DRUG: Treatment sequence B|DRUG: Treatment sequence C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Neuroplasticity of Multisensory Cortical Areas Induced by Musical Training: a Translational Approach (MusicPlast)
Status: RECRUITING
Conditions: Dyslexia|Aging Problems
Interventions: BEHAVIORAL: MusicPlast|BEHAVIORAL: MusicPlast Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Of Activity-Based Intervention On Activity, Participation And Kinesiophobia In Patients With Tendon Injury
Status: UNKNOWN
Conditions: Flexor Tendon Rupture
Interventions: OTHER: physiotherapy|OTHER: activity-based therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Internet-based Self Applied Treatment Program for Prolonged Grief Disorder (PGD)
Status: COMPLETED
Conditions: Grief
Interventions: BEHAVIORAL: GROw: An Internet based Self Applied Treatment Program for Prolonged Grief Disorder (PGD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: ALKS 5461|DRUG: ALKS 5461 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Needle-based Confocal Laser Endomicroscopy in Fluoroscopy-guided Procedures
Status: COMPLETED
Conditions: Lung Percutaneous Biopsy|Liver Percutaneous Biopsy
Interventions: DEVICE: CT-guided percutaneous biopsy or ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Lopinavir Plus Ritonavir and Arbidol Against Novel Coronavirus Infection
Status: COMPLETED
Conditions: Coronavirus Infections
Interventions: DRUG: Lopinavir and Ritonavir Tablets|DRUG: Arbidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of QVA149 (Indacaterol/Glycopyrrolate) Compared to Placebo and to Indacaterol in Patients With Moderate to Severe Stable Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: indacaterol/glycopyrrolate|DRUG: indacaterol|DRUG: glycopyrrolate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of the RCMOP Sequential Therapy as a First-line Treatment for Patients With Intermediate-to-high Risk Diffuse Large B-cell Lymphoma Who Had Incomplete Remission.
Status: NOT_YET_RECRUITING
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Mitoxantrone hydrochloride liposome injection|DRUG: RiTUXimab Injection|DRUG: Cyclophosphamid|DRUG: Vincristine|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis
Status: RECRUITING
Conditions: Sclerosis, Multiple|Autoimmune Diseases of the Nervous System|Nervous System Diseases|Autoimmune Diseases
Interventions: DRUG: Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Immunogenetic Profiling of Goeckerman Therapy in the Treatment of Psoriasis Vulgaris
Status: ACTIVE_NOT_RECRUITING
Conditions: Psoriasis Vulgaris|Psoriasis
Interventions: OTHER: Goeckerman Therapy|DRUG: Crude Coal Tar Only|DEVICE: Phototherapy Only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characterization of Immune Semaphorin in Non Alcoholic Fatty Liver Disease and NASH
Status: COMPLETED
Conditions: Non Alcoholic Fatty Liver Disease
Interventions: OTHER: Evaluation of the staging of fibrosis liver|OTHER: Determine the expression level of semaphorin|OTHER: Determination of the composition of immunity cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Smoking Tobacco Cessation Integrated Program of Patients Treated for the Head and the Neck Cancer
Status: COMPLETED
Conditions: Carcinoma, Squamous Cell of Head and Neck|Tobacco Use Disorder
Interventions: BEHAVIORAL: Experimental arm|OTHER: Control arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: VFI in Healthy Vessels
Status: COMPLETED
Conditions: Carotid Artery Stenosis|Superficial Femoral Artery Stenosis
Interventions: DIAGNOSTIC_TEST: Blood speckle tracking|DIAGNOSTIC_TEST: Ultrasound particle Imaging Velocimetry|DIAGNOSTIC_TEST: 4D flow MRI|DIAGNOSTIC_TEST: Conventional duplex
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants
Status: COMPLETED
Conditions: Clubfoot
Interventions: OTHER: Milk bottle administration|OTHER: Water bottle administration|OTHER: Sucrose bottle administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Ulcer Healing|Diabetic Foot Ulcer
Interventions: DEVICE: human keratin graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)
Status: RECRUITING
Conditions: Asthma, Aspirin-Induced|Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: Mepolizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Sentinel Lymph Node Mapping in Upper Gastro-Intestinal Cancer: A Feasibility Clinical Investigation
Status: RECRUITING
Conditions: Gastric Cancer|Esophageal Cancer
Interventions: COMBINATION_PRODUCT: FerroTrace® and FerroMag Sentinel Lymph Node Mapping (SLNM) System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Cholecystectomy and Quality of Recovery
Status: RECRUITING
Conditions: Laparoscopic Cholecystectomy
Interventions: PROCEDURE: Subcostal TAP block|OTHER: Port site local anesthetic infiltration|OTHER: No intervention or local anesthetic administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examination of Changes on Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) in Patients Who Receive Gliadel Wafers During Initial Surgery for Glioblastoma Multiforme. Response or Failure to Gliadel Wafers for Subjects With Glioblastoma Multiforme.
Status: WITHDRAWN
Conditions: Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma
Interventions: OTHER: MRS Spectroscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Liposomal Bupivacaine Versus Non-liposomal Bupivacaine for Total Shoulder Arthroplasty
Status: COMPLETED
Conditions: Analgesia
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fortified Milk, Growth and Micronutrient Status in Mexican Toddlers (MilkGrowth)
Status: COMPLETED
Conditions: Undernutrition
Interventions: DIETARY_SUPPLEMENT: Growing milk|DIETARY_SUPPLEMENT: Fortified milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Video-assisted Umbilical Fascial Closure in Laparoscopic Cholecystectomy
Status: COMPLETED
Conditions: Cholelithiasis (Without Cholecystitis)|Pain, Postoperative|Hernia Incisional
Interventions: PROCEDURE: video-assisted umbilical closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SUPERvised Three-month Exercise Program in MEN With Prostate cAncer Receiving Androgen-deprivaTioN thERapy
Status: SUSPENDED
Conditions: Prostatic Neoplasms|Metastasis
Interventions: OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Self-hypnosis for Weight Loss in Type 2 Diabetics
Status: COMPLETED
Conditions: Obesity|Diabetes Mellitus, Type 2|Weight Reduction
Interventions: BEHAVIORAL: Self-hypnosis|BEHAVIORAL: CDE training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Uptake of Early Infant Diagnosis of HIV for the Prevention of Mother-to-child Transmission of HIV
Status: COMPLETED
Conditions: HIV Infections|Acquired Immunodeficiency Syndrome
Interventions: OTHER: Text message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Primary Failure of Eruption (PFE) : Highlighting of Clinical, Radiological and Genetic Diagnostic Criteria: Consequences on the Therapeutic Management
Status: RECRUITING
Conditions: Primary Failure of Eruption
Interventions: GENETIC: genetic analysis|RADIATION: panoramic radiography|RADIATION: teleradiography|RADIATION: intraoral X-rays|RADIATION: CT scan of maxillary and mandible
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants
Status: COMPLETED
Conditions: Neoplastic Syndrome|Non-melanomatous Skin Cancer
Interventions: DRUG: sirolimus|GENETIC: comparative genomic hybridization|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: protein expression analysis|GENETIC: proteomic profiling|OTHER: laboratory biomarker analysis|OTHER: mass spectrometry|PROCEDURE: biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Combination or Sequential Treatment With PEGASYS (Peginterferon Alfa-2a) and Entecavir in Patients With HBeAg Positive Chronic Hepatitis B
Status: COMPLETED
Conditions: Hepatitis B, Chronic
Interventions: DRUG: entecavir|DRUG: entecavir|DRUG: peginterferon alfa-2a [Pegasys]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study Evaluating Efficacy, Safety and Pharmacokinetics of Trilaciclib In Small Cell Lung Cancer Patients
Status: COMPLETED
Conditions: Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: Trilaciclib, carboplatin, etoposide，or Topotecan|DRUG: placebo, carboplatin, etoposide，or Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Culprit-first in Primary Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Coronary Artery Disease|Ischemic Heart Disease|Myocardial Infarction|STEMI|Stent
Interventions: PROCEDURE: Culprit-first PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Controlled Trial of a 4-Month Quinolone-Containing Regimen for the Treatment of Pulmonary Tuberculosis
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: DRUG: Gatifloxacin combined regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate Transdermal System (MTS)|OTHER: placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of ONO-4578 and XELOX/FOLFOX Plus Bevacizumab in Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: ONO-4578|DRUG: ONO-4538|DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Fluorouracil|DRUG: Calcium Levofolinate Hydrateb|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Outcomes in Terms of Disability and Quality of Life for Patients Undergoing Posterior Cranial Fossa Craniectomy in the Context of Compressive Cerebellar Hematoma
Status: COMPLETED
Conditions: Craniectomy|Quality of Life|Cerebellar Haematoma|Handicaps Physical|Handicap Mental
Interventions: BEHAVIORAL: SF36 questionary
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Effectiveness of Two Types of Aligners Based on Stratification by Type of Movement
Status: RECRUITING
Conditions: Crowding, Tooth|Tipped Tooth or Teeth|Rotation of Tooth|Malocclusion, Angle's Class
Interventions: DEVICE: direct-printed aligner|DEVICE: thermoformed aligner
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: De-Escalation Postoperative Radiotherapy for Oral Squamous Cell Carcinoma With pCR/MPR.
Status: RECRUITING
Conditions: De-escalated Radiotherapy; Head and Neck Cancer
Interventions: RADIATION: Continuous, hyperfractionated, accelerated radiotherapy(CHART)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab in Combination With Cisplatin and Intensity Modulated Radiotherapy (IMRT) in Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Cisplatin|RADIATION: IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multinational Clinical Study Comparing Isatuximab, Carfilzomib And Dexamethasone To Carfilzomib And Dexamethasone In Relapse And/Or Refractory Multiple Myeloma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Plasma Cell Myeloma
Interventions: DRUG: isatuximab SAR650984|DRUG: carfilzomib|DRUG: dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development of Typology-based Smoking Relapse Prevention: A Q-methodology and a Pilot Randomized Controlled Trial
Status: RECRUITING
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: typology-based intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: DRUG: High THC cannabis|DRUG: High CBD cannabis|DRUG: THC/CBD cannabis|DRUG: Placebo cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biological Therapy Plus Chemotherapy in Treating Patients With Metastatic or Recurrent Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: recombinant interferon alfa|DRUG: fluorouracil|DRUG: isotretinoin|PROCEDURE: surgical procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?
Status: COMPLETED
Conditions: Optic Neuritis
Interventions: DEVICE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Escitalopram|DRUG: Placebo|DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Follow-up Strategy of Chronic Hepatitis B for Early Detection and Diagnosis of Hepatocellular Carcinoma: A Randomized Control Trial
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: OTHER: 3 months|OTHER: 6 months|OTHER: 3 month ultrasound(US)+3 month CT/MRI+3 month US+3 month CT/MRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Hepatic and Renal Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1841788 (ODM-201)
Status: COMPLETED
Conditions: Pharmacokinetics|Hepatic Insufficiency|Renal Insufficiency
Interventions: DRUG: BAY1841788
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Auriculotherapy on Pain and Functional Capacity of Individuals With Chikungunya Fever
Status: COMPLETED
Conditions: Chikungunya Fever
Interventions: PROCEDURE: True auriculotherapy with seeds|PROCEDURE: Placebo Auriculotherapy with seeds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ozurdex for Retinal Vein Occlusion Study (ORVO Study)
Status: COMPLETED
Conditions: Retinal Vein Occlusion
Interventions: DRUG: dexamethasone implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Green Tea Extract in Preventing Cancer in Former and Current Heavy Smokers With Abnormal Sputum
Status: COMPLETED
Conditions: Lung Cancer|Tobacco Use Disorder
Interventions: DRUG: defined green tea catechin extract|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of Blood Pressure on the Postoperative Cognitive Dysfunction
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: PROCEDURE: Liberal group|PROCEDURE: Restrictive group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fluoroscopy Guided Lumbar Facet Joint Injection Versus Ultrasound Guided Injection in Patients With Low Back Pain Due to Facet Syndrome
Status: COMPLETED
Conditions: Facet Syndrome of Lumbar Spine
Interventions: PROCEDURE: Fluoroscopy guided Facet joint injection|PROCEDURE: Ultrsound guided Facet joint injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: sEphB4-HSA in Treating Patients With Kaposi Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Skin Kaposi Sarcoma
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|BEHAVIORAL: Quality-of-Life Assessment|BIOLOGICAL: Recombinant EphB4-HSA Fusion Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Pemigatinib in Combination With Atezolizumab and Bevacizumab for Treatment of Advanced Cholangiocarcinoma With FGFR2 Fusion
Status: NOT_YET_RECRUITING
Conditions: Advanced Cholangiocarcinoma|FGFR2 Fusion
Interventions: DRUG: Pemigatinib|DRUG: Atezolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)
Status: RECRUITING
Conditions: Glioma
Interventions: DRUG: Rhenium Liposome Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
Status: RECRUITING
Conditions: Obesity
Interventions: OTHER: Blood GLP1|OTHER: Blood No treated GLP1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pre-post Intervention Study Evaluating Home-based Management of Patients With COPD or CAP
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease|Community-acquired Pneumonia
Interventions: DEVICE: Current Health platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT