pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of an Investigational Pentavalent Meningococcal ABCYW Vaccine in Adults and Adolescents
Status: ACTIVE_NOT_RECRUITING
Conditions: Meningococcal Immunisation|Healthy Volunteers|Meningococcal Infection
Interventions: BIOLOGICAL: Pentavalent Meningococcal ABCYW vaccine|BIOLOGICAL: MenACYW conjugate vaccine|BIOLOGICAL: Meningococcal group B vaccine|BIOLOGICAL: Meningococcal group B vaccine|BIOLOGICAL: Meningococcal group B vaccine|BIOLOGICAL: MenACYW conjugate vaccine|BIOLOGICAL: Placebo|BIOLOGICAL: MenABCYW conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: LISA Post Market Clinical Follow-Up Study: Documentation of Clinical Outcomes After Surgery With LISA Implant
Status: RECRUITING
Conditions: Chronic Low-back Pain|Herniated Disc|Degenerative Disc Disease|Lumbar Canal Stenosis
Interventions: DEVICE: Lumbar Implant for Stiffness Augmentation (LISA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FDG-PET to Investigate SGN-15 and Docetaxel in Patients With Advanced Non-Small Cell Lung Carcinoma
Status: COMPLETED
Conditions: Non-Small Cell Lung Carcinoma
Interventions: DRUG: SGN-15, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015)
Status: COMPLETED
Conditions: Complicated Intra-abdominal Infections
Interventions: DRUG: Ceftolozane/Tazobactam|DRUG: Metronidazole|DRUG: Meropenem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Immunogenicity and Safety of a Trivalent Influenza Vaccine Containing the 2013/2014 Formulation of Enzira® Vaccine in Healthy Volunteers
Status: COMPLETED
Conditions: Influenza, Human
Interventions: BIOLOGICAL: Trivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Recombinant Human Growth Hormone Injection for Short Children With Small for Small for Gestational Age(SGA)
Status: UNKNOWN
Conditions: Small for Gestational Age Infant
Interventions: DRUG: Recombinant Human Growth Hormone Injection|DRUG: Recombinant Human Growth Hormone Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AC-CHOP Versus CHOP in Patients With Previously Untreated PTCL-TFH
Status: ENROLLING_BY_INVITATION
Conditions: Peripheral T-cell Lymphoma Targeted Therapy
Interventions: DRUG: Azacitidine|DRUG: Chidamide|DRUG: Cyclophosphamide|DRUG: Epirubicin|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioma|Hematopoietic and Lymphoid Cell Neoplasm|Lymphoma|Metastatic Malignant Solid Neoplasm|Neuroendocrine Neoplasm|Recurrent Adult Soft Tissue Sarcoma|Recurrent Bladder Carcinoma|Recurrent Breast Carcinoma|Recurrent Chronic Lymphocytic Leukemia|Recurrent Colorectal Carcinoma|Recurrent Head and Neck Carcinoma|Recurrent Lung Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Melanoma|Recurrent Pancreatic Carcinoma|Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Recurrent Prostate Carcinoma|Recurrent Renal Cell Carcinoma|Recurrent Thyroid Gland Carcinoma|Refractory Chronic Lymphocytic Leukemia|Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma|Stage III Breast Cancer AJCC v7|Stage III Colorectal Cancer AJCC v7|Stage III Cutaneous Melanoma AJCC v7|Stage III Lung Cancer AJCC v7|Stage III Pancreatic Cancer AJCC v6 and v7|Stage III Prostate Cancer AJCC v7|Stage III Renal Cell Cancer AJCC v7|Stage III Soft Tissue Sarcoma AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIA Colorectal Cancer AJCC v7|Stage IIIA Cutaneous Melanoma AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIB Colorectal Cancer AJCC v7|Stage IIIB Cutaneous Melanoma AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IIIC Colorectal Cancer AJCC v7|Stage IIIC Cutaneous Melanoma AJCC v7|Stage IV Breast Cancer AJCC v6 and v7|Stage IV Colorectal Cancer AJCC v7|Stage IV Cutaneous Melanoma AJCC v6 and v7|Stage IV Lung Cancer AJCC v7|Stage IV Pancreatic Cancer AJCC v6 and v7|Stage IV Prostate Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7|Stage IV Soft Tissue Sarcoma AJCC v7|Stage IVA Colorectal Cancer AJCC v7|Stage IVB Colorectal Cancer AJCC v7|Unresectable Solid Neoplasm
Interventions: OTHER: Pharmacological Study|DRUG: Romidepsin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Eupolio(IPV)'s Safety, Long-term Protective Effect and Boosting Effect of One Booster Dose in the Three Primary Vaccination Plus Boosting Schedule, and Protective Effect in the Schedule With Bivalent OPV in Infants
Status: RECRUITING
Conditions: Poliomyelitis|Vaccine Reaction
Interventions: BIOLOGICAL: Eupolio
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of AZD9291 Plus MEDI4736 Versus AZD9291 Monotherapy in NSCLC After Previous EGFR TKI Therapy in T790M Mutation Positive Tumours
Status: COMPLETED
Conditions: Locally Advanced or Metastatic EGFR T790M+ NSCLC
Interventions: DRUG: AZD9291|DRUG: MEDI4736
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing Recurrences of Chronic Subdural Hematoma in Adult Patients by Middle Meningeal Artery Embolization
Status: RECRUITING
Conditions: Hematoma, Subdural, Chronic
Interventions: PROCEDURE: Surgery plus endovascular MMA embolization|PROCEDURE: Surgery alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: "OK 2004 Study" (Only Kaletra 2004 Study): Study to Evaluate Suspending Nucleosides From Triple-Drug Therapy in HIV Subjects
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Stopping nucleosides and continuing lopinavir/ritonavir monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Two Loading Regimens of Sunitinib or Bevacizumab Alternating With Cisplatin and Gemcitabine as Induction Therapy for Locally Advanced Nasopharyngeal Carcinoma (NPC)
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: 12.5mg sunitinib with Cisplatin and Gemcitabine|DRUG: 25mg Sunitinib alternating with Cisplatin and Gemcitabine|DRUG: 7.5mg/kg Bevacizumab alternating with Cisplatin and Gemcitabine|DRUG: 2.5mg/kg Bevacizumab alternating with Cisplatin and Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect Sildenafil and Estradiiol Valerate on Endometrial Thickness in Infertile Women
Status: COMPLETED
Conditions: Endometrial Thickness
Interventions: DRUG: estradiol valerate and sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest
Status: UNKNOWN
Conditions: Out-Of-Hospital Cardiac Arrest
Interventions: OTHER: Targeted therapeutic mild hypercapnia|OTHER: Targeted normocapnia (Standard care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intra-Articular Dexamethasone to Prevent Post-Traumatic Osteoarthritis: A Pilot Study
Status: COMPLETED
Conditions: Distal Radius Fracture|Osteoarthritis
Interventions: DRUG: Dexamethasone|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
Status: WITHDRAWN
Conditions: Recurrent Squamous Cell Carcinoma of the Head or Neck|Metastatic Squamous Cell Carcinoma of the Head or Neck|Squamous Cell Carcinoma
Interventions: DRUG: Nivolumab|DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Seizure Prophylaxis in Patients With Glioma or Brain Metastasis
Status: TERMINATED
Conditions: Glioma|Glioma of Brain|Brain Tumor
Interventions: DRUG: Lacosamide|DRUG: Levetiracetam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING LOW LEVEL LASER IN CHILDREN
Status: NOT_YET_RECRUITING
Conditions: Molar Incisor Hypomineralization
Interventions: PROCEDURE: Photobiomodulation usinf low level laser therapy|PROCEDURE: Resin-based sealant|PROCEDURE: Glass ionomer sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of SmithKline Beecham (GlaxoSmithKline [GSK]) Biologicals' Candidate Adjuvanted Vaccines (287615)
Status: COMPLETED
Conditions: Hepatitis B Disease
Interventions: BIOLOGICAL: 287615 containing HBsAg with adjuvants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Oral Probiotics and Secondary Bacterial Pneumonia in Severe COVID-19
Status: COMPLETED
Conditions: COVID-19 Lower Respiratory Infection|Microbial Colonization|Severe COVID-19|Secondary Bacterial Pneumonia
Interventions: COMBINATION_PRODUCT: Oral probiotics|OTHER: Oral placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preventing pAIn With NMDA Antagonists - Steroids in Thoracoscopic lObectomy Procedures (PAIN-STOP) Pilot Trial
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: NMDA active|DRUG: Steroid active|DRUG: NMDA placebo|DRUG: Steroid placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACBT and High Frequency Chest Wall Oscillations in COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: High frequency chest wall oscillation|OTHER: Active cycle of breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Hodgkin Lymphoma Treatment Trial With Low Cumulative Doses of Chemotherapy Agents and Reduced Radiation.
Status: RECRUITING
Conditions: Pediatric Hodgkin's Disease
Interventions: RADIATION: No radiotherapy if CR at the end of chemotherapy.|DRUG: Low risk with complete early response after two cycles of ABVD chemotherapy schedule. Only one more ABVD course is delivered.|DRUG: Low risk with partial remisssion after 4 cycles of ABVD chemotherapy schedule. Two ESHAP courses are delivered.|RADIATION: IN 30Gy RT in case of PR at the end of chemotherapy|DRUG: Intermediate risk with complete early response after two cycles of ABVD chemotherapy schedule. Three more ABVD courses are delivered.|DRUG: Intermediate risk with partial remission after two cycles of ABVD chemotherapy schedule. Four more chemotherapy courses are delivered alternating ESHAP and ABVD.|DRUG: High risk with complete early response after 1 ABVD and 1 ESHAP courses. Four more chemotherapy courses are delivered alternating ESHAP and ABVD.|DRUG: High risk with partial remission after 1 ABVD and 1 ESHAP courses. Six more chemotherapy courses are delivered alternating ESHAP and ABVD.|DRUG: Low risk with partial remission at early response assessment after two cycles of ABVD chemotherpay schedule. Two ABVD courses are delivered.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Chemoembolisation Using Irinotecan Bead Prior to Surgery in Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DEVICE: Irinotecan Bead
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Time Period of Standing Frame on Spasticity and Gait in Children With Spastic Cerebral Palsy.
Status: UNKNOWN
Conditions: Spastic Cerebral Palsy|Spastic Gait
Interventions: OTHER: conventional physical therapy|OTHER: standing frame.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Irinotecan and Veliparib in Treating Patients With Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Solid Neoplasm
Interventions: DRUG: Ferumoxytol|DRUG: Irinotecan Sucrosofate|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Magnetic Resonance Imaging|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heparin Alone vs. Heparin-Aspirin Combo in Free Flap Survival
Status: NOT_YET_RECRUITING
Conditions: Complication,Postoperative
Interventions: DRUG: LMW Heparin 5000 U/ML-Aspirin 75 MG|DRUG: LMW Heparin 5000 U/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Bootcamp: A Pilot Tele-Sleep Program for Former National Football League (NFL) Players
Status: COMPLETED
Conditions: Sleep|Insomnia|Pain|Quality of Life
Interventions: BEHAVIORAL: Brief Behavioral Therapy for Insomnia (BBTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Temporo-occipital Transcranial Magnetic Brain Stimulation on Aversive Episodic Memory Performance
Status: RECRUITING
Conditions: Memory, Episodic
Interventions: DEVICE: rTMS (cTBS experiment)|DEVICE: rTMS (cTBS sham)|DEVICE: rTMS (cTBS active control)|DEVICE: rTMS (high frequency)|DEVICE: rTMS (low frequency)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of the High Intensity Focused Ultrasound (HIFU) Technique for Patients With Unresectable Pancreatic Tumor Treatment (PULS)
Status: RECRUITING
Conditions: Non-Resectable Pancreas Carcinoma
Interventions: PROCEDURE: HIFU intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis
Status: COMPLETED
Conditions: Urinary Tract Infections|Acute Pyelonephritis
Interventions: DRUG: Finafloxacin 800 mg i.v. once daily|DRUG: Finafloxacin placebo i.v. once daily|DRUG: Finafloxacin 800 mg tablets once daily|DRUG: Finafloxacin placebo tablets once daily|DRUG: Ciprofloxacin 400 mg i.v. twice daily|DRUG: Ciprofloxacin placebo i.v. twice daily|DRUG: Ciprofloxacin 500 mg oral twice daily|DRUG: Ciprofloxacin placebo oral twice daily
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Clinical and Biological Effects of Leucocyte and Platelet-rich Fibrin (L-PRF) on Post-extraction Sockets Healing
Status: COMPLETED
Conditions: Tooth Extraction
Interventions: OTHER: leucocyte and platelet-rich fibrin (L-PRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lovastatin for Treatment of Brain Arteriovenous Malformations
Status: UNKNOWN
Conditions: Cerebral Arteriovenous Malformation
Interventions: DRUG: Lovastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study to Evaluate Tariquidar (XR9576), a Selective MDR-1 Inhibitor, in Chemotherapy Resistant Advanced Breast Cancer
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Predictive Immunological Parameters of Molecular Complete Remission in Patients With Chronic Myelogenous Leukemia in Chronic Phase and Treated With Tyrosine Kinase Inhibitor
Status: COMPLETED
Conditions: Chronic Leukemia
Interventions: OTHER: Additional biological samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: KİNECT® - Video Games Based Physiotherapy Programme in Patients With Breast Cancer Surgery
Status: COMPLETED
Conditions: Breast Cancer|Upper Extremity Dysfunction|Mastectomy
Interventions: OTHER: study group|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Topical 5% Minoxidil and Potent Topical Corticosteroid Versus Intralesional Corticosteroid in the Treatment of Alopecia Areata
Status: COMPLETED
Conditions: Alopecia Areata
Interventions: DRUG: Triamcinolone Acetonide|DRUG: Minoxidil 5 % Topical Spray|DRUG: clobetasol propionate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Testing the Causal Effects of a Civic Engagement Intervention on Health and Wellbeing Among Youth (I-ACTED)
Status: RECRUITING
Conditions: Mental Health Wellness 1|Social Interaction|Health Attitude
Interventions: BEHAVIORAL: Participating in Action Civics program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pregnancy Testing in Northern Uganda
Status: UNKNOWN
Conditions: Pregnancy Tests
Interventions: DIAGNOSTIC_TEST: Pregnancy test at Baseline|DIAGNOSTIC_TEST: Free pregnancy test for the future use|DIAGNOSTIC_TEST: Pregnancy test for the future use with randomzied price
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Plasma Exchanges in Multiple Sclerosis (MS) Relapses
Status: COMPLETED
Conditions: Multiple Sclerosis|Multiple Sclerosis, Acute Relapsing
Interventions: PROCEDURE: plasma exchange|PROCEDURE: sham exchanges procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain After Buffered Vs Non Buffered Articaine
Status: RECRUITING
Conditions: Pain
Interventions: DRUG: Buffered articaine|DRUG: Non buffered articaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of Mycophenolic Acid in Patients With an Autoimmune Bullous Dermatose, Pemphigus or Cicatricial Pemphigoid.
Status: COMPLETED
Conditions: Autoimmune Bullous Dermatose
Interventions: DRUG: Cellcept® in autoimmune bullous dermatoses
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study to Evaluate Gadavist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (MRI) of Vascular Diseases in Chinese Patients
Status: COMPLETED
Conditions: Vascular Diseases
Interventions: DRUG: Gadobutrol (Gadavist, Gadovist, BAY86-4875)|DRUG: Gadopentate dimeglumine (Magnevist, BAY86-4882)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Virtual Reality for Post Operative Pain Management After Total Knee Arthroplasty
Status: TERMINATED
Conditions: Virtual Reality|Pain, Postoperative|Knee Arthropathy|Anesthesia|Hypnosis
Interventions: DEVICE: VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Acupuncture on Symptoms, Gastric Emptying Rate and Glucose Control in Patients With Diabetic Gastroparesis
Status: TERMINATED
Conditions: Diabetic Gastroparesis
Interventions: PROCEDURE: Acupuncture|DRUG: Motilium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ORL-1F (L-fucose) in Patients With Leukocyte Adhesion Deficiency Type II
Status: COMPLETED
Conditions: Leukocyte Adhesion Deficiency, Type II
Interventions: DRUG: L-fucose
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Estrogen Receptor-Positive Breast Carcinoma|Metastatic Breast Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|PROCEDURE: Computed Tomography|DRUG: F-18 16 Alpha-Fluoroestradiol|PROCEDURE: Positron Emission Tomography|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for Post Cesarean Delivery Analgesia
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Education Intervention in Encouraging Health Providers to Talk With Cancer Patients About the Use of Complementary and Alternative Medicine
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific|Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: OTHER: educational intervention|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Influence of Patient Sex on Pain Control and Multimodal Analgesia in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain, Postoperative
Interventions: OTHER: Multimodal analgesia including pregabalin|OTHER: Multimodal analgesia not including pregabalin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stem Cell Therapy Combined Hormone Replacement Therapy in Patients With Premature Ovarian Failure
Status: UNKNOWN
Conditions: Premature Ovarian Failure，
Interventions: BIOLOGICAL: human umbilical cord mesenchymal stem cells|BIOLOGICAL: hUCMSCs and hCBMNCs|BIOLOGICAL: human cord blood mononuclear cells|DRUG: Hormone Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid
Status: COMPLETED
Conditions: Encephalitis
Interventions: DRUG: AVI-4065 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Experimental Medication BMS-986278 Given to Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: BMS-986278|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Find Out if Intensive Diabetes Clinic and Continuous Glucose Monitors Help Teenagers With Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BEHAVIORAL: Diabetes related psychological counseling and education|DEVICE: Continuous Glucose Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical and Histomorphometric Analysis of Collagen Matrix Versus Connective Tissue Graft in Mucogingival Surgery in Orthodontic Patients
Status: UNKNOWN
Conditions: Gingival Recession
Interventions: DEVICE: Collagen matrix|OTHER: autologous connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of Oral Phytate (InsP6) in the Prevention of Progression of the Cardiovascular Calcifications
Status: UNKNOWN
Conditions: Heart Valve Disease|Aortic Stenosis
Interventions: DIETARY_SUPPLEMENT: Phytine (phytate)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diagnostic Yield of Colonoscopy Surveillance in Testicular Cancer Survivors Treated With Platinum-based Chemotherapy
Status: COMPLETED
Conditions: Testicular Cancer|Colorectal Neoplasms
Interventions: DIAGNOSTIC_TEST: Colonoscopy surveillance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open Label, Multi-Center, Randomized, Parallel Group Study Comparing the Efficacy and Safety of Insulin VIAject™ and Regular Human Insulin in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: VIAject™|DRUG: Regular Human Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Autologous Adipose-Derived Stromal Vascular Fraction to Treat Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Arthritis, Degenerative
Interventions: OTHER: intra-articular space injection of SVF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study to Assess the Safety and Performance of the Easyx Antia Liquid Embolic in Intracranial Interventions
Status: UNKNOWN
Conditions: Arterial Embolization
Interventions: DEVICE: Liquid Embolic
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)
Status: COMPLETED
Conditions: Hemophagocytic Lymphohistiocytosis|Chronic Active Epstein-Barr Virus Infection|Chronic Granulomatous Disease|HIGM-1|Leukocyte Adhesion Deficiency|IPEX
Interventions: BIOLOGICAL: Hematopoietic Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-response Study of Exendin-9,39 on Glucose Metabolism
Status: COMPLETED
Conditions: Pancreatic Effects of 9,39-Exendin and 9,36-GLP-1
Interventions: DRUG: saline infusion|DRUG: GLP-1-9,36 infusion|DRUG: Exendin-9,39 at low dose|DRUG: Exendin-9,39 at high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assertive Community Treatment With CBT and SST for Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Cognitive Behavioral Social Skills Training (CBSST)|OTHER: Assertive Community Treatment (ACT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glutamine With Topical Corticosteroids for Lichen Planus Treatment
Status: COMPLETED
Conditions: Lichen Penis Planus
Interventions: DRUG: Glutamine Cap/Tab|DRUG: Miconazole Oral gel|DRUG: Kenacort in orabase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab in Treating Patients With Persistent or Recurrent Cancer of the Cervix
Status: COMPLETED
Conditions: Cervical Squamous Cell Carcinoma|Recurrent Cervical Cancer
Interventions: BIOLOGICAL: bevacizumab|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validity of a Home Respiratory Polygraphy for the Diagnosis of Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Obstructive Sleep Apnea (OSA)
Interventions: OTHER: Home Respiratory Polygraphy (APNIA)|OTHER: Standard Polysomnography (PSG)|OTHER: Home Respiratory Polygraphy (APNIA)|OTHER: Standard Polysomnography (PSG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluating Visual Acuity and Initial Fit Performance of Two Soft Contact Lenses
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: EMO-200|DEVICE: EMO-118
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety
Status: TERMINATED
Conditions: Arthroplasty
Interventions: DRUG: Tapentadol IR (CG5503)|DRUG: Placebo|DRUG: Oxycodone HCL IR|DRUG: Tapentadol IR (CG5503)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OCT Guided vs COmplete Pci in patieNts With sT Segment Elevation myocArdial infarCtion and mulTivessel Disease
Status: RECRUITING
Conditions: Acute Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: OCT - optical coherence tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-1084 With Midazolam and Digoxin in Healthy Participants (MK-1084-009)
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: MK-1084|DRUG: Midazolam|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Glembatumumab Vedotin (CDX-011) in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Metastatic gpNMB Over-expressing Triple Negative Breast Cancer
Interventions: DRUG: CDX-011|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders
Status: TERMINATED
Conditions: Phobia, Social|Panic Disorder|Agoraphobia|Obsessive-Compulsive Disorder|Anxiety Disorders|Major Depressive Disorder
Interventions: DRUG: Sertraline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Saccharomyces Boulardii in Clinical Presentation and Quality of Life Patient With IBS
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Saccharomyces Boulardii 250 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness
Status: RECRUITING
Conditions: Dry Eye Disease|Xerostomia
Interventions: OTHER: Osteopathic protocol of Sphenopalatine Ganglion Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stockholm Preterm Interaction-Based Intervention
Status: ACTIVE_NOT_RECRUITING
Conditions: Extreme Prematurity
Interventions: BEHAVIORAL: Stockholm Preterm Interaction-Based Intervention (SPIBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intratumoral Microdosing of Motolimod in HNSCC
Status: TERMINATED
Conditions: HNSCC
Interventions: DRUG: Motolimod|BIOLOGICAL: Nivolumab|COMBINATION_PRODUCT: Motolimod + Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: WT-1 Analog Peptide Vaccine in Malignant Pleural Mesothelioma After Combined Modality Therapy
Status: COMPLETED
Conditions: Malignant Pleural Mesothelioma
Interventions: BIOLOGICAL: WT-1-vaccine Montanide + GM-CSF|BIOLOGICAL: Montanide adjuvant + GM-CSF (This arm is closed)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Mepolizumab 100 Milligram (mg) Subcutaneous (SC) in Indian Participants Aged Greater Than or Equal to (>=) 18 Years With Severe Eosinophilic Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: Mepolizumab|DRUG: Salbutamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Salvage Hypofractionated Accelerated Versus Standard Radiotherapy for Biochemical Failure After Prostatectomy
Status: RECRUITING
Conditions: Prostate Cancer|Biochemical Recurrence|Radiation|Hypofractionation|Dose Escalation|Survival|Radiation Toxicity|Quality of Life
Interventions: RADIATION: Salvage radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Observation and Feasibility Study of Prevora, Integrated Into Homecare Visits of High-risk Adults
Status: NOT_YET_RECRUITING
Conditions: COPD (Chronic Obstructive Pulmonary Disease)|CHF (Congestive Heart Failure)|Dialysis|Chronic Metabolic Disorder
Interventions: DRUG: Prevora
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: POCUS Analysis of the Gastric Emptying Time of Orange Juice With and Without Pulp
Status: COMPLETED
Conditions: Preoperative Period|Anesthesia
Interventions: OTHER: Point of care gastric ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Rapid Ventricular Pacing During Cerebral Aneurysm Surgery: a Study Concerning the Safety for Heart and Brain
Status: RECRUITING
Conditions: Cardiac Pacing, Artificial|Aneurysm, Brain|Arteriovenous Malformations, Cerebral
Interventions: PROCEDURE: Rapid ventricular pacing|PROCEDURE: No rapid ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Assess the Efficacy and the Safety of VisuXL® Gel Administered in Patients Affected by Moderate DED
Status: UNKNOWN
Conditions: Dry Eye Syndromes
Interventions: DEVICE: VisuXL® Gel|DEVICE: HYLO®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Inhaled TPI 1100 in Healthy Volunteers
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: TPI 1100
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity
Status: COMPLETED
Conditions: Dentin Sensitivity
Interventions: OTHER: stannous fluoride|OTHER: sodium monofluorophosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cryoprotection of Chemotherapy-induced Oral Mucositis After Autologous Stem Cell Transplantation, a Randomized Study
Status: COMPLETED
Conditions: Cryotherapy Effect
Interventions: DEVICE: Cooral™|OTHER: cryotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Gumarontinib Combined With 3rd EGFR-TKI in Patients With Non-small Cell Lung Cancer.
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: gumarontinib|DRUG: third-generation EGFR-TKI (Osimertinib, Almonertinib or Furmonertinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Integrating Contextual Factors Into Clinical Decision Support
Status: COMPLETED
Conditions: Medical Errors|Decision Support Systems, Clinical|Diagnostic Errors
Interventions: OTHER: Contextual clinical decision support|BEHAVIORAL: Contextual survey
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Clinical Study to Evaluate the Efficacy and Safety of Monopolar Radiofrequency Combined With SkinCeuticals A.G.E and Skinceuticals CE FERULIC for Improving Facial Skin Elasticity, Tightening and Fading Fine Lines
Status: NOT_YET_RECRUITING
Conditions: Skin Aging
Interventions: DEVICE: monopolar radiofrequency|OTHER: SkinCeuticals A.G.E and Skinceuticals CE FERULIC|OTHER: Standard Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Thoracic Orthopedic Manual Therapy and Biopsychosocial Variables on Signs of Shoulder Impingement
Status: COMPLETED
Conditions: Shoulder Impingement
Interventions: OTHER: Thoracic High Velocity, Low Amplitude Thrust Maneuver (HVLATM)|OTHER: Scapular High Velocity, Low Amplitude Thrust Maneuver
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Oral Bacteriotherapy to Promote Anal HPV Clearance in HIV Positive Individuals
Status: UNKNOWN
Conditions: HIV|Anal Dysplasia
Interventions: DIETARY_SUPPLEMENT: Vivomixx|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia
Status: COMPLETED
Conditions: Sickle Cell Anemia
Interventions: DRUG: Hydroxyurea|DRUG: L-Arginine|DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: The Use of Hepatitis C Positive Kidneys in Hepatitis C Negative Kidney Transplant Recipients
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Transplantation|Hepatitis C
Interventions: DRUG: sofosbuvir/velpatasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Evaluation in African Americans Using RAS Therapy
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Telmisartan 20mg|DRUG: Telmisartan 40mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: LEADERS FREE II: BioFreedom™ Pivotal Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Coronary Syndrome|High Bleeding Risk
Interventions: DEVICE: BioFreedom™ Drug Coated Coronary Stent System|DRUG: Antiplatelet Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
Status: RECRUITING
Conditions: Anesthesia|General Anesthesia|Analgesics, Opioid|Opioid Free Anesthesia|Postoperative Ileus|Colorectal Surgery|Laparoscopic Surgery|Analgesia|Dexmedetomidine|Lidocaine|Ketamine
Interventions: DRUG: Acetaminophen, Gabapentin|DRUG: Acetaminophen, Gabapentin|DRUG: Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine|DRUG: Dexamethasone, Ondansetron|DRUG: Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate|DRUG: Lidocaine 1% Injectable Solution, Sufentanil|DRUG: Sevoflurane, Sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting
Status: RECRUITING
Conditions: Thyroid Eye Disease|Vasculitis|COPD Exacerbation Acute|Asthma|Inflammatory Disease
Interventions: OTHER: No intervention - prednisolone is taken as part if routine clinical care.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety of and Immune Response to a Hepatitis B Virus Vaccine Given With a Booster (CpG7909 ODN) in HIV Infected and HIV Uninfected People
Status: COMPLETED
Conditions: HIV Infections|Hepatitis B
Interventions: DRUG: CpG7909 oligodeoxynucleotides (ODN)|BIOLOGICAL: Hepatitis B virus vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of Suvaro®OD Tablet in Patients With Dyslipidemia
Status: RECRUITING
Conditions: Dyslipidemia
Interventions: DRUG: Rosuvastatin Immediate-Release Tablet (IRT) 10mg|DRUG: Rosuvastatin orally disintegrating tablet (SUVARO®ODT) 10mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing Zanubrutinib With Bendamustine Plus Rituximab in Participants With Previously Untreated CLL or SLL
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Zanubrutinib|DRUG: Bendamustine|DRUG: Rituximab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium
Status: COMPLETED
Conditions: Cardiac Surgery
Interventions: DRUG: total anaesthesia and postoperative inhaled sedation with Sevoflurane|DRUG: total intravenous anaesthesia with Propofol.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cemiplimab in Combination With Platinum-Doublet Chemotherapy in First-Line (1L) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) in Adult United States (US) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Non-small Cell Lung Cancer
Interventions: DRUG: REGN2810|OTHER: Platinum-doublet chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Relative Bioavailability Study of Ribavirin 200 Capsules and Rebetol 200 mg Capsules in Females Under Non-Fasting Conditions
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Ribavirin 200 Capsules (Geneva Pharmaceutical, U.S.A.)|DRUG: Rebetol 200 Capsules (Schering Corporation, U.S.A.)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of WNT974 in Combination With LGX818 and Cetuximab in Patients With BRAF-mutant Metastatic Colorectal Cancer (mCRC) and Wnt Pathway Mutations
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: WNT974|DRUG: LGX818|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone, Exercise, Alendronate, and Caloric Restriction
Status: RECRUITING
Conditions: Bone Loss
Interventions: DRUG: Bisphosphonate|BEHAVIORAL: Resistance Training/Bone-Loading Exercise|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes Following Pre-marking of Episiotomy Location
Status: RECRUITING
Conditions: Episiotomy; Complications|Episiotomy Extended by Laceration|Episiotomy Infection
Interventions: OTHER: Pre-marking of episiotomy location
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION