pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Oral Clofarabine in Adult Patients With Myelodysplastic Syndromes (MDS)
Status: TERMINATED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: clofarabine|DRUG: clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-seronegative Persons
Status: RECRUITING
Conditions: Epstein-Barr Virus Infection|Infectious Mononucleosis|Herpesvirus
Interventions: DRUG: Matrix-M1 Adjuvant|DRUG: EBV gp350-Ferritin Vaccine|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation of The Effects of Holistic Group Exercise Program on Muscle Thickness and Physical Performance in Older Adults With Sarcopenia
Status: NOT_YET_RECRUITING
Conditions: Sarcopenia
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb®808 in Combination With Pembrolizumab in Advanced Solid Tumors
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Melanoma Excluding Uveal Melanoma|Non-small Cell Lung Cancer, Squamous or Non-squamous|Urothelial Carcinoma|Renal Cell Carcinoma, Clear Cell|Castration-resistant Prostate Cancer|Ovarian Cancer, Epithelial|TNBC - Triple-Negative Breast Cancer|Colorectal Cancer
Interventions: BIOLOGICAL: XmAb®808|BIOLOGICAL: Keytruda® (pembrolizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Long-term Evaluation (up to 5 Years) of First Booster Immunization With Novartis' TBE Vaccine for Adults in Adolescents and Adults
Status: COMPLETED
Conditions: Tick Born Encephalitis
Interventions: BIOLOGICAL: TBE vaccine for adults
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has Not Responded to Treatment
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung|Thyroid Neoplasms
Interventions: DRUG: LOXO-260
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Foot Reflexology and Foot Bath on Paın And Qualıty of Lıfe Applıed to Dıabetıc Neuropathıc Paın
Status: COMPLETED
Conditions: Diabetic Neuropathy, Painful
Interventions: OTHER: randomized controlled study
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial Comparing the Efficacy and Safety of Liraglutide 1.8 mg/Day to Liraglutide 0.9 mg/Day in Japanese Subjects With Type 2 Diabetes Mellitus.
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of the Melanocortin-4 Receptor in Hypoactive Sexual Desire Disorder
Status: COMPLETED
Conditions: Hypoactive Sexual Desire Disorder
Interventions: DRUG: Bremelanotide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Functional Electrical Stimulation Versus TheraTogs on Treatment of Children With Hemiplegic Cerebral Palsy.
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: OTHER: Functional Electrical Stimulation|OTHER: TheraTogs Orthotic Undergarment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Míranos! Program, a Preschool Obesity Prevention RCT
Status: COMPLETED
Conditions: Obesity|Healthy Eating|Physical Activity|Health Knowledge, Attitudes, Practice|Gross Motor Development
Interventions: BEHAVIORAL: Center-based Intervention|BEHAVIORAL: Home-based Intervention|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation
Status: UNKNOWN
Conditions: Evidence of Liver Transplantation|Myocardial Injury
Interventions: DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Fine Art Photographs and Visualization Tapes to Improve Surgical Recovery in Breast Cancer
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: BEHAVIORAL: Visualization relaxation|BEHAVIORAL: Visual Milieu Enhancement (Fine art photograph)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Dietary Fatty Acid Supplementation on Symptoms and Bronchial Inflammation in Patients With Asthma
Status: UNKNOWN
Conditions: Allergic Asthma|Allergy to House Dust Mite
Interventions: DIAGNOSTIC_TEST: Bronchial allergen provocation (BAP)|DIAGNOSTIC_TEST: Nasal provocation test (NPT)|DIAGNOSTIC_TEST: Methacholine test|DIAGNOSTIC_TEST: Peak nasal expiratory flow (PNIF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: WBI-1001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinician-Patient Communication in Lung Cancer Care
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Cancer
Interventions: BEHAVIORAL: Questionnaire|BEHAVIORAL: Patient Interview|BEHAVIORAL: Audio recordings of clinical consultations|BEHAVIORAL: Questionnaire|BEHAVIORAL: 2-hour empathic communication skills training|BEHAVIORAL: Standardized Patient Assessments|BEHAVIORAL: Training evaluation|BEHAVIORAL: Patient recruitment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Weight-loss Treatment in Obese Patients With Psoriatic Arthritis
Status: COMPLETED
Conditions: Obesity|Psoriatic Arthritis|Metabolic Syndrome|Psoriasis|Cardiovascular Disease
Interventions: DIETARY_SUPPLEMENT: Very Low Energy Diet (VLED)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Blood Purification for Regulation of Early Inflammatory Response In Severe Acute Pancreatitis
Status: UNKNOWN
Conditions: Acute Pancreatitis
Interventions: OTHER: CVVH 6h|OTHER: CVVH 10h|OTHER: CVVHDF 6h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of PD 0332991 in Patients With Recurrent Rb Positive Glioblastoma
Status: TERMINATED
Conditions: Glioblastoma|Gliosarcoma|Anaplastic Astrocytoma
Interventions: DRUG: PD 0332991 (pre-surgery)|DRUG: PD 0332991|PROCEDURE: Resection as clinical care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Assessment of Colonic Motility
Status: TERMINATED
Conditions: Colon Disease|Functional Constipation|Electroenterography|Slow Transit|Hirschsprung Disease
Interventions: OTHER: Elektro-Entero-Graphy procedure|OTHER: EEnG Questionnaire|OTHER: Gold Standard Questionnaire
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allogeneic Mesenchymal Stem Cells for Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis of Knee Joint
Interventions: BIOLOGICAL: Ex- vivo cultured adult allogeneic MSCs|BIOLOGICAL: Plasmalyte-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: electrical cardioversion|DRUG: propafenone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Butylphthalide's Safety and Efficacy for Improving Neurological Function Prognosis in Patients With Cardiac Arrest (BNCA Trial)
Status: NOT_YET_RECRUITING
Conditions: Butylphthalide|Cardiac Arrest|Neuroprotective Drugs
Interventions: DRUG: Butylphthalide and Sodium Chloride Injection|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Concomitant Mitral Regurgitation by Mitral Valve Clipping in Patients With Successful Transcatheter Aortic Valve Implantation.
Status: UNKNOWN
Conditions: Aortic Stenosis|Mitral Regurgitation
Interventions: DEVICE: Mitral Valve Clipping|DEVICE: TAVI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of NNC 0123-0000-0338 in Healthy Subjects
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: NNC 0123-0000-0338|DRUG: placebo|DRUG: insulin glargine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women
Status: COMPLETED
Conditions: Tobacco Use Disorder
Interventions: OTHER: Very low nicotine content cigarettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma
Status: RECRUITING
Conditions: Newly Diagnosed Glioblastoma|Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype|Gliosarcoma|Glioblastoma Multiforme
Interventions: DRUG: Balstilimab|DRUG: Botensilimab|DRUG: Liposomal Doxorubicin|DEVICE: Sonocloud-9 (SC-9)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
Status: RECRUITING
Conditions: Crohn's Disease
Interventions: DRUG: Upadacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the ORTHO-LBNP System
Status: COMPLETED
Conditions: Orthostatic Hypotension|Ischemia|Hypoxia
Interventions: OTHER: Head up tilt (HUT)|OTHER: Lower body negative pressure (LBNP)|OTHER: Head down tilt (HDT)|DEVICE: Tilt table|DEVICE: LBNP chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Role of Aprotinin in Glucagon Degradation, Measurement by Radioimmunoactive Method (RIA) I125
Status: COMPLETED
Conditions: Hyperglucagonemia
Interventions: OTHER: Fasting glycemia|OTHER: Hypoglycemia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL)
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: PROMUS Element Coronary Stent System|DRUG: Aspirin|DRUG: Thienopyridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: Ularitide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Satisfaction and Adaptation After Elevation of Vertical Dimension of Occlusion Using Overlay Denture or Fixed Crowns
Status: UNKNOWN
Conditions: Patient Satisfaction
Interventions: DEVICE: partial overlay denture|OTHER: fixed temporary crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Paracetamol With or Without Ketoprofen in the Management of Pain for Patients Receiving Brachytherapy (KETOCOL-1304)
Status: UNKNOWN
Conditions: Uterine Cervical Cancer|Upper Aerodigestive Tract Neoplasms
Interventions: DRUG: Paracetamol|DRUG: Ketoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allergy Immunotherapy in the Management of Eosinophilic Esophagitis
Status: WITHDRAWN
Conditions: Eosinophilic Esophagitis
Interventions: BIOLOGICAL: Allergy immunotherapy ("allergy shots")
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closure of Fasciotomy Wounds: A Prospective, Observational Study of a Continuous External Tissue Expander
Status: TERMINATED
Conditions: Wounds and Injuries|Compartment Syndrome
Interventions: DEVICE: DermaClose fasciotomy closure|DEVICE: Vessel loop
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TEE and Dysphagia in Lung Transplantation
Status: RECRUITING
Conditions: Lung Transplant|Dysphagia
Interventions: DIAGNOSTIC_TEST: Transesophageal Echocardiography (TEE) with limited number of TEE clips|DIAGNOSTIC_TEST: Transesophageal Echocardiography (TEE) with number of TEE clips per attending anesthesiologist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Subcutaneous Hydrocortisone Children With Congenital Adrenal Hyperplasia
Status: COMPLETED
Conditions: Congenital Adrenal Hyperplasia|Hyperplasia|Adrenal Hyperplasia|Congenital Disorders|Adrenocortical Hyperfunction|Disorders of Sex Development|Urogenital Abnormalities|Genetic Diseases, Inborn|Steroid Metabolic Diseases, Inborn|Adrenal Gland Disease|Hydrocortisone
Interventions: DRUG: Subcutaneous hydrocortisone|DRUG: Standard glucocorticoid therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Spanish Study for Molecular Characterization of Thyroid Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Differentiated Thyroid Carcinoma|Medullary Thyroid Carcinoma
Interventions: OTHER: Immunohistochemistry (IHC)|OTHER: Fluorescence In-Situ Hybridization (FISH)|OTHER: Oncomine Focus Assay Platform with 52 genes
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Prospective, Randomized, Double-blind, Placebo Controlled Study to Assess the Impact of ORMD-0801 (Insulin Capsules) on the Exogenous Insulin Requirements of Type 1 Diabetics
Status: COMPLETED
Conditions: Diabetes Mellitus Type 1
Interventions: BIOLOGICAL: ORMD-0801 Capsules|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Zidovudine (AZT) Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Patients With Little or No Previous Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Saquinavir|DRUG: Zidovudine|DRUG: Zalcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus
Status: UNKNOWN
Conditions: Oral Lichen Planus
Interventions: DRUG: topical chamomile
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Tolerability and Effect of Three Single-dose Regimens of BIA 9-1067
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: BIA 9-1067|DRUG: BIA 9-1067|DRUG: BIA 9-1067|DRUG: Placebo|DRUG: Levodopa/Carbidopa|DRUG: Levodopa/Benzerazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Population Pharmacokinetics of Intravenous Posaconazole in Critically Ill Patients
Status: COMPLETED
Conditions: Systemic Fungal Infections
Interventions: DRUG: Posaconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Partnering With WIC to Prevent Excessive Weight Gain in Pregnancy
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Overweight|Pregnancy Related
Interventions: BEHAVIORAL: Antenatal Obesity Treatment (AO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Ixazomib in Pediatric Participants With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LLy)
Status: WITHDRAWN
Conditions: Precursor Cell Lymphoblastic Leukemia-lymphoma
Interventions: DRUG: Ixazomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: DNA Evaluation of Fragments for Early Interception - Lung Cancer Training Study (DELFI-L101 Study)
Status: RECRUITING
Conditions: Lung Cancer|Head and Neck Cancer|Esophageal Cancer|Bladder Cancer|Kidney Cancer|Stomach Cancer|Colorectal Cancer|Pancreas Cancer|Liver Cancer|Skin Cancer
Interventions: OTHER: Blood Sample Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dialysis Membranes and Hemodynamic Tolerance
Status: COMPLETED
Conditions: Dialysis Membranes and Hemodynamic Tolerance
Interventions: DEVICE: Revaclear|DEVICE: Helixone high flux|DEVICE: Xevonta|DEVICE: Helixone low flux
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Retinal Function After Intravitreal Ranibizumab for Age-related Macular Degeneration
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: ranibizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exploratory Study of Treatment Sensitivity and Prognostic Factors in a Efficacy and Safety Study of mFOLFOX6 + Bevacizumab Versus mFOLFOX6 + Panitumumab Therapy in Patients With Chemotherapy-naïve Unresectable Advanced or Recurrent Colorectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: oxaliplatin (OXA), levofolinate calcium (l-LV), 5-FU, panitumumab|DRUG: oxaliplatin (OXA), levofolinate calcium (l-LV), 5-FU, bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Laparotomy Versus Percutaneous Endoscopic Correction of Myelomeningocele
Status: RECRUITING
Conditions: Neural Tube Defects|Spina Bifida|Myelomeningocele|Chiari Malformation
Interventions: DEVICE: Fetoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Decitabine Compared With Standard Supportive Care in Treating Older Patients With Myelodysplastic Syndrome
Status: UNKNOWN
Conditions: Leukemia|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms
Interventions: DRUG: decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dyadic Yoga Intervention for the Improvement of Healthcare Utilization and Quality of Life in Patients With Head and Neck Cancer Undergoing Chemoradiation and Their Caregivers
Status: RECRUITING
Conditions: Head and Neck Carcinoma
Interventions: OTHER: Best Practice|OTHER: Exercise Intervention|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation Study of Talk Parenting Skills
Status: COMPLETED
Conditions: Parenting Practices|Self Efficacy|Stress|Child Behavior|Emotional Adjustment|Sleep Problems|Parent-Child Relations
Interventions: BEHAVIORAL: The Talk Parenting Skill for Alexa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immersive Multimedia as an Adjunctive Measure for Pain Control in Cancer Patients
Status: RECRUITING
Conditions: Chronic Pain|Cancer
Interventions: DEVICE: Virtual Reality Headset|OTHER: 2D PC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Caregivers Training Using Artificial Intelligence and Virtual Reality
Status: RECRUITING
Conditions: Medication Errors and Other Product Use Errors and Issues|Caring
Interventions: OTHER: control|OTHER: Virtual Reality|OTHER: Augmented reality|OTHER: 360 videos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Vorinostat in Treating Women Who Are Undergoing Surgery For Newly Diagnosed Stage I -III Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage III Breast Cancer
Interventions: DRUG: vorinostat|OTHER: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair
Status: RECRUITING
Conditions: GERD|Hiatal Hernia
Interventions: PROCEDURE: LAPAROSCOPIC PARAESOPHAGEAL HIATAL HERNIA REPAIR COMBINED WITH TRANSORAL INCISIONLESS FUNDOPLICATION
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Prospective Study of Arthrodesis of Finger Distal Interphalangeal Joints Using the Kerifuse Device
Status: RECRUITING
Conditions: Osteoarthritis Finger|Osteoarthritis Thumb
Interventions: PROCEDURE: KeriFuse implant implantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Temporary Epicardial Pace Wire With Integrated Sensor for Continuous Postoperative Monitoring of Myocardial Function
Status: ENROLLING_BY_INVITATION
Conditions: Cardiac Disease|Myocardial Dysfunction
Interventions: DEVICE: CS1 System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Tirzepatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Sit-to-stand Test and Six-minute Walk Test in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: PROCEDURE: sit-to-stand test|PROCEDURE: six-minutes walking test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: The Effect of the Treatment Environment on Pain, Function, Self Efficacy and Satisfaction in RCRSP
Status: NOT_YET_RECRUITING
Conditions: Shoulder Pain|Subacromial Pain Syndrome|Rotator Cuff Syndrome of Shoulder and Allied Disorders
Interventions: BEHAVIORAL: Patient Education|BEHAVIORAL: Exercise Therapy|BEHAVIORAL: Cold Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: MC5-A Scrambler Therapy or TENS Therapy in Treating Patients With Chemotherapy-Induced Peripheral Neuropathy
Status: COMPLETED
Conditions: Pain|Peripheral Neuropathy|Tingling
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: MC5-A Scrambler Therapy|OTHER: Questionnaire Administration|OTHER: Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Status: COMPLETED
Conditions: Enlargement of Tonsil or Adenoid
Interventions: DIAGNOSTIC_TEST: Complete Blood Count|DIAGNOSTIC_TEST: Tympanometry|PROCEDURE: Tonsillectomy and/or adenoidectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Imatinib in Scleroderma
Status: COMPLETED
Conditions: Scleroderma, Localized|Scleroderma, Systemic
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel/Carboplatin (PC) Followed by Gefitinib Versus PC in Advanced Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Paclitaxel/Carboplatin/Gefitinib|DRUG: Paclitaxel/Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Controlled-Release Carvedilol Compared to Immediate-Release Carvedilol in Patients With Primary Hypertension
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: Carvedilol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levobupivacaine and Lidocaine for Paravertebral Block Causes Greater Hemodynamic Oscillations Than Levobupivacaine
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Tumors|Hypotension|Bradycardia
Interventions: DRUG: levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Inhalation Dose Study to Assess Efficacy, Pharmacokinetics (PK), Safety and Tolerability of AZD8871 in Patients With Long-term Lung Diseases.
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: AZD8871|DRUG: Anoro® Ellipta®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease
Interventions: DRUG: Cu(II)ATSM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia Grade 2/3|High-risk HPV (Any Strain)
Interventions: DRUG: Artesunate Suppositories
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation EUCLIDES-01 for the Calculation of the Area of Skin Lesions
Status: COMPLETED
Conditions: Skin Lesion|Traumatic Ulcer|Hematoma|Pressure Ulcer|Venous Ulcer|Arterial Ulcer|Diabetic Neuropathic Ulcer|Ischemic Ulcer|Surgical Wound|Ulcer, Skin|Diabetic Foot Ulcer
Interventions: DEVICE: Clinicgram Euclides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Discontinuation of CDK4/6 Inhibitors in Patients With Metastatic HR Positive, HER2 Negative Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Continuation of CDK4/6 inhibitor Palbociclib|DRUG: Discontinuation of CDK4/6 inhibitor Palbociclib|DRUG: Continuation of CDK4/6 inhibitor -Palbociclib|DRUG: Discontinuation of CDK4/6 inhibitor -Palbociclib|DRUG: Continuation of CDK4/6 inhibitor Abemaciclib|DRUG: Discontinuation of CDK4/6 inhibitor Abemaciclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men
Status: NOT_YET_RECRUITING
Conditions: Sexually Transmitted Diseases
Interventions: DRUG: Doxycyclin|DRUG: Pentoxifylline|DRUG: Nitazoxanide 500Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Lorcaserin for Smoking Cessation
Status: TERMINATED
Conditions: Tobacco Use Disorder|Smoking Cessation
Interventions: DRUG: Lorcaserin Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of V950 in People With Alzheimer Disease (V950-001 AM7)
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: V950|BIOLOGICAL: ISCOMATRIX™|BIOLOGICAL: Placebo to V950
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Psoriatic Arthritis|Ankylosing Spondylitis|Hypertension
Interventions: DRUG: Etanercept|DRUG: Adalimumab|DRUG: Certolizumab|DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary Tract Infection
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DEVICE: Mona Lisa Touch|DRUG: Conjugated estrogen|DRUG: Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Effectiveness of the Left Atrial Appendage Closure Therapy Using BSJ003W
Status: COMPLETED
Conditions: Atrial Fibrillation Non-Rheumatic
Interventions: DEVICE: BSJ003W
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Acupuncture for Individuals With Stable Angina
Status: TERMINATED
Conditions: Angina, Stable|Chest Pain|Microvascular Angina|Heart Failure
Interventions: OTHER: Acupuncture|OTHER: Non-pain related video health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding in Patients With Child A Cirrhosis
Status: UNKNOWN
Conditions: Portal Hypertension
Interventions: DEVICE: 8mm-TIPS|PROCEDURE: endoscopic variceal ligation (EVL)|DRUG: Propranolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Blincyto Amgen Acrotech BioPharma PH2 Blincyto Marqibo R/R Philadelphi CD19+ ALL
Status: WITHDRAWN
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ammoxetine Hydrochloride Enteric-coated Tablets in Healthy Subject
Status: UNKNOWN
Conditions: Depression
Interventions: DRUG: Ammoxetine Hydrochloride Enteric-coated Tablets|DRUG: placebo enteric-coated tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clopidogrel Bioequivalence Study in Healthy Subjects
Status: COMPLETED
Conditions: Bioequivalence, AUC, Cmax, Pharmacokinetics
Interventions: DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Brexucabtagene Autoleucel (KTE-X19) in Participants With Relapsed/Refractory Mantle Cell Lymphoma (Cohort 3)
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed/Refractory Mantle Cell Lymphoma
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|BIOLOGICAL: Brexucabtagene autoleucel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
Status: RECRUITING
Conditions: Cesarean Delivery Affecting Newborn|Obesity, Childhood|Intestinal Microbiome|Microbiota|Host Microbial Interactions|Gastrointestinal Microbiome
Interventions: BIOLOGICAL: Vaginal Seeding|OTHER: No Vaginal Seeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Immune Response and the Safety Profile of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Taiwanese Adults 65 Years of Age and Older
Status: COMPLETED
Conditions: Influenza (Healthy Volunteers)
Interventions: BIOLOGICAL: High-Dose Quadrivalent Influenza Vaccine|BIOLOGICAL: Standard-Dose Quadrivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Demyelination and Remyelination in Multiple Sclerosis (MS) Detected by Brain Amyloid PET-CT
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: 18F-florbetaben PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities
Status: COMPLETED
Conditions: Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities|Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile|Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities
Interventions: BEHAVIORAL: Low intensity exercise session|BEHAVIORAL: Moderate intensity exercise session|BEHAVIORAL: High intensity exercise session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-VII: Sirolimus-eluting (Ultimaster) vs. Everolimus-Eluting Stents (Xience)
Status: TERMINATED
Conditions: Coronary Artery Disease|Coronary Stenosis
Interventions: DEVICE: Ultimaster stent|DEVICE: Xience alpine stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extensive Peritoneal Lavage After Curative Gastrectomy for Gastric Cancer: A Randomised Controlled Trial
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: PROCEDURE: Extensive Peritoneal Lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumor|Microsatellite Instability-High (MSI-H) Solid Tumors|Cutaneous Melanoma|Pancreatic Cancer|Breast Cancer (HR+HER2-)
Interventions: DRUG: LY3300054|DRUG: Ramucirumab|DRUG: Abemaciclib|DRUG: Merestinib|DRUG: LY3321367
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anti-TNF Agents for the Treatment of Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Etanercept|DRUG: Adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung
Status: RECRUITING
Conditions: Lung Metastases|Colorectal Cancer Metastatic|Colorectal Cancer
Interventions: DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a Phase I-II Clinical Trial
Status: COMPLETED
Conditions: Liver Failure|Cirrhosis
Interventions: PROCEDURE: injection of progenitor of hepatocyte drived from Mesenchymal stem cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Rivaroxaban Versus Warfarin in Acute Ischemic Stroke With Atrial Fibrillation
Status: COMPLETED
Conditions: Ischemic Stroke|Transient Ischemic Attack
Interventions: DRUG: Rivaroxaban|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Colchicine in Periprocedural Myocardial Infarction: the Role of Alpha Defensin
Status: UNKNOWN
Conditions: Inflammation|Myocardial Infarction
Interventions: DRUG: Colchicine Loading Dose|DRUG: Standard of care treatment prior to elective PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease
Status: UNKNOWN
Conditions: Eye Diseases
Interventions: DRUG: Botulinum toxin A injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of an Anti-PD-1 mAb for Patients With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Lymphoma|Lung Cancer
Interventions: BIOLOGICAL: JS001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Spinal Needle Type on Optic Nerve Sheath Diameter
Status: NOT_YET_RECRUITING
Conditions: Spinal Anesthesia|Intracranial Pressure Change|Optic Nerve Sheath Diameter|Orthopedic Surgery|Cerebrospinal Fluid Leak
Interventions: PROCEDURE: 25 PP|PROCEDURE: 25 Q|PROCEDURE: 27 Q|OTHER: Optic Nerve Sheath Measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-dispense Comfort Comparison of Two Silicone Hydrogel Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Lotrafilcon A contact lens|DEVICE: Senofilcon A contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Pharmacokinetics of BRCX014 in Patients With Glioblastoma
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: DRUG: Temozolomide|DEVICE: Optune
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sodium-glucose Cotransporter (SGLT) 2 Inhibitors on Cystine Stone Formation: A Preliminary Study
Status: RECRUITING
Conditions: Cystinuria
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study Looking at How Well the Drug Eligard Works and How Well it is Tolerated by the Body of Patients With Advanced Prostate Carcinoma in the Russian Federation
Status: COMPLETED
Conditions: Advanced Prostate Carcinoma
Interventions: DRUG: Eligard 45 mg Exposure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Colorectal Cancer Metastatic
Interventions: BIOLOGICAL: BioTTT001 hepatic artery infusion|DRUG: toripalimab|DRUG: regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological Parameters Changes After Autologous Blood Transfusion of Red Blood Cells (200 ml) in Healthy Volunteers.
Status: RECRUITING
Conditions: The Focus is on the Detection of the Consequences of Autologous Blood Transfusion in Healthy Volunteers
Interventions: PROCEDURE: Autologous Blood Transfusion|OTHER: No transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: SIRT1(rs7069102 ) Gene Polymorphism in Chronic Obstructive Pulmonary Disease at Egyptian Patients
Status: RECRUITING
Conditions: Genotyping of SIRT1in Chronic Obstructive Pulmonary Disease
Interventions: GENETIC: genotyping of SIRT1 in chronic obstructive patients
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation and Validation of Endogenous Markers for the Assessment of CYP3A Activity in Korean Healthy Subjects Using Metabolomics
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Midazolam I.V.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Tolerability, Safety and Efficacy of Lubricin (150 µg/ml) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops in Patients With Moderate Dry Eye (DE)
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DEVICE: Lubricin|DEVICE: Sodium Hyaluronate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Anti-tumor Activity of SNK01 (NK Cells) Administered in Combination With Chemotherapy or Chemotherapy / Cetuximab in Local Advanced or Metastatic Non-small Cell Lung Cancer Patients Who Failed Tyrosine Kinase Inhibitor Treatment
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: SNK01 (Super Natural Killer Cells 01)|DRUG: GC|BIOLOGICAL: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Deep Breathing and Transcutaneus Electrical Nerve Stimulation on Heart Rate Variability
Status: UNKNOWN
Conditions: Rheumatoid Arthritis|Systemic Lupus Erythematosus|Healthy Participants
Interventions: DEVICE: Non-invasive auricular electrical transcutaneous vagus nerve stimulation|OTHER: Deep breathing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Liraglutide Versus Placebo When Added to Basal Insulin Analogues With or Without Metformin in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of SINGLE PORT (SP) Robotic Technology in Colorectal Surgery
Status: RECRUITING
Conditions: Colo-rectal Cancer|Rectal Prolapse|Colostomy Stoma|Colorectal Disorders
Interventions: DEVICE: Single port robotic colorectal surgical procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Quality of Life and Nutritional Status After Two Surgical Techniques in Pancreatoduodenectomy
Status: COMPLETED
Conditions: Delayed Gastric Emptying
Interventions: PROCEDURE: Pancreatoduodenectomy with antrectomy|PROCEDURE: Pylorus-preserving pancreatoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT