pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety, Tolerability, and Efficacy of mFOLFIRINOX ± BNT321 as Adjuvant Therapy Following Curative Resection in Patients With Pancreatic Adenocarcinoma
Status: RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: BNT321 Dose Level 1|DRUG: BNT321 Dose Level 2|DRUG: mFOLFIRINOX|DRUG: BNT321 RP2D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Electrophysiologic Measures of Treatment Response in Alzheimer Disease
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Aricept|DRUG: Exelon|DRUG: Nicoderm Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO)
Status: RECRUITING
Conditions: Ovarian Neoplasm Epithelial|Fallopian Tube Neoplasms|Peritoneal Neoplasms|High-grade Serous Ovarian Carcinoma (HGSOC)|Low-grade Serous Ovarian Carcinoma (LGSOC)|Ovarian Endometrioid Carcinoma
Interventions: DRUG: Letrozole 2.5mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Intranasal Insulin on Motor and Non-motor Symptoms in Parkinson's Disease Patients
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: Insulin|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using a Diabetic Kidney Disease (DKD) Registry to Treat to Multiple Targets (TMT)
Status: COMPLETED
Conditions: Diabetic Kidney Disease
Interventions: OTHER: Telephone Reminder|OTHER: Doctor-Nurse Follow Up|OTHER: Personalized Risk Report for Patient Empowerment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of an HIV Vaccine (AVX101) in HIV Uninfected Volunteers in the United States and South Africa
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: AVX101|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Evaluate Efficacy and Safety of PENNEL Capsule in the Patients With Chronic Liver Disease
Status: COMPLETED
Conditions: Chronic Liver Disease
Interventions: DRUG: NISSEL|DRUG: PENNEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Evaluation of a Web Based Decision Aid for Patients With Hip Osteoarthritis
Status: COMPLETED
Conditions: Hip Osteoarthritis|Osteoarthritis
Interventions: OTHER: Patient Decision Aid (PtDA)|OTHER: Brochure with general information about osteoarthritis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor
Status: COMPLETED
Conditions: Clear Cell Sarcoma of the Kidney|Recurrent Wilms Tumor and Other Childhood Kidney Tumors|Rhabdoid Tumor of the Kidney|Stage I Wilms Tumor|Stage II Wilms Tumor|Stage III Wilms Tumor|Stage IV Wilms Tumor|Stage V Wilms Tumor
Interventions: GENETIC: DNA methylation analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: reverse transcriptase-polymerase chain reaction|OTHER: diagnostic laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community
Status: UNKNOWN
Conditions: HIV Infections|Sexually Transmitted Diseases|Papillomavirus Infections|Genital Herpes|Gonorrhea|Chlamydia Infections|Syphilis|Bacterial Vaginosis
Interventions: PROCEDURE: Male circumcision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: memantine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Pharmacokinetic Study of Iron Isomaltoside 1000 (Monofer®) Administered as Single Bolus Injections in Subjects With Stage 5 Chronic Kidney Disease on Dialysis Therapy (CKD-5D)
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: DRUG: Monofer®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: BIOLOGICAL: NK-92/5.28.z|DRUG: Ezabenlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Behavioral Programs to Treat Sleep Problems in Individuals With Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Sleep Initiation and Maintenance Disorders
Interventions: BEHAVIORAL: Walking Program|BEHAVIORAL: Light Exposure Program|BEHAVIORAL: Combined Education, Walking and Light Exposure Program|BEHAVIORAL: Routine Medical Care with Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects
Status: RECRUITING
Conditions: Periodontitis|Periodontal Bone Loss|Periodontal; Lesion
Interventions: PROCEDURE: NIPSA (Non-incised papilla surgical approach)|PROCEDURE: NIPSA plus connective tissue graft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anti-Influenza Hyperimmune Intravenous Immunoglobulin Pilot Study (INSIGHT 005: Flu-IVIG Pilot)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Intravenous hyperimmune immunoglobulin (Flu-IVIG)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carbonic Anhydrase Inhibitors and Carbonation: A Novel Approach to Reduce Soda Consumption
Status: ENROLLING_BY_INVITATION
Conditions: Obesity
Interventions: DRUG: Acetazolamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Distal Jejunal-release Dextrose in Obese Participants
Status: RECRUITING
Conditions: Obese
Interventions: DRUG: APHD-012|DRUG: APHD-012P
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementing the Transcultural Social-Ethical-Care Model -TEC-MED for Older People in the Mediterranean Basin
Status: COMPLETED
Conditions: Older People|Care Dependency|Social Exclusion
Interventions: OTHER: Socio-health care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced NSCLC Through Gene Expression Profiling
Status: TERMINATED
Conditions: Advanced Non-Small Cell Lung Cancer
Interventions: DRUG: Carboplatin|DRUG: Paclitaxel|PROCEDURE: Gene expression profiling (analysis) of tumor samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia
Status: COMPLETED
Conditions: Achalasia
Interventions: PROCEDURE: Peroral Endoscopic Myotomy (POEM)|PROCEDURE: Laparoscopic Heller Myotomy (LHM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methods of Providing Information Prior to an Alveolar Bone Graft
Status: RECRUITING
Conditions: Cleft Lip and Palate
Interventions: OTHER: ACE - AudioVisual Guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 89Zr-DFO-REGN3767 in PET Scans in People With Diffuse Large B Cell Lymphoma (DLBCL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Large B-cell Lymphoma|DLBCL
Interventions: DRUG: 89Zr-DFO-REGN3767|DIAGNOSTIC_TEST: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Walking in Nature (vs. an Urban Setting) on the Wellbeing of Postsecondary Students.
Status: ACTIVE_NOT_RECRUITING
Conditions: Affect|Wellness, Psychological|Depressive Symptoms|Anxiety Disorders and Symptoms|Stress|Sleep|Non-suicidal Self-injury
Interventions: BEHAVIORAL: A 4-week walking intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Evaluation of Afatinib in Maintenance Therapy in Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: AFATINIB|DRUG: Placebo of AFATINIB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Trastuzumab in Combination With Capecitabine and Cisplatin in Patients With Tissue HER2- But Serum HER2+ AGC
Status: RECRUITING
Conditions: Gastric or Gastroesophageal Junction(GEJ) Adenocarcinoma
Interventions: DRUG: Trastuzumab, Capecitabine and Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IMPACT: A Study to Explore the Efficacy and Safety of Paliperidone ER in Patients With Acute Agitation
Status: COMPLETED
Conditions: Psychomotor Agitation|Acute Disease
Interventions: DRUG: Paliperidone ER|DRUG: Benzodiazepine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Telomerase Reactivation With Danazol in Ovarian Function.
Status: COMPLETED
Conditions: Ovarian Reserve
Interventions: DRUG: Danazol/Placebo|OTHER: Without intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensity Modulated Radiation Therapy - Gyne Cancer (GY03.2)
Status: COMPLETED
Conditions: Cervix Neoplasms|Uterine Neoplasms|Vaginal Neoplasms
Interventions: PROCEDURE: Intensity Modulated Radiation Therapy Boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug-drug Interaction Study Beteewn ASK120067 and Rifampicin or Itraconazole
Status: COMPLETED
Conditions: Locally Advanced or Metastatic NSCLC
Interventions: DRUG: Rifampicin; ASK120067|DRUG: ASK120067;itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Group Life Skill Intervention to Enhance Well-Being Among Higher Education Students
Status: COMPLETED
Conditions: Psychological Distress|Mental Health Issue|Quality of Life|Well-Being, Psychological
Interventions: BEHAVIORAL: Group Life Skill Intervention|BEHAVIORAL: Treatment as Usual for Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Inhibition of Complement Activation (Eculizumab) in Guillain-Barre Syndrome Study
Status: UNKNOWN
Conditions: Gullian Barre Syndrome
Interventions: DRUG: Eculizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Safety and Efficacy of Estetrol in Healthy Men
Status: COMPLETED
Conditions: Prostatic Neoplasms
Interventions: DRUG: estetrol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tailored Multicomponent Intervention for Remote Physical Activity Promotion in Inactive Adults
Status: COMPLETED
Conditions: Sedentary Lifestyle
Interventions: OTHER: "Phone" group|OTHER: "Phone and SMS" group|OTHER: "single writing" group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks - Netherlands
Status: UNKNOWN
Conditions: Abdominal Aortic Aneurysm
Interventions: DEVICE: IMPEDE-FX Embolization Plug
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chest Physiotherapy After Bariatric Aurgery - A Comparison Between Incentive Spirometry and Expiratory Positive Airway Pressure (Epap)
Status: COMPLETED
Conditions: Obesity
Interventions: DEVICE: Incentive Spirometry - RESPIRON|DEVICE: Kit Epap®:
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Safety of Omegaven in Pediatric Patients With Parenteral Nutrition-Associated Cholestasis (PNAC)
Status: WITHDRAWN
Conditions: Parenteral Nutrition Associated Liver Disease|Essential Fatty Acid Deficiency|Neurocognitive Deficit|Malnutrition|Pediatric ALL
Interventions: DRUG: Omegaven® (fish oil triglycerides) Injectable Emulsion
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Health Dialogue Intervention Versus Opportunistic Screening for Type 2 Diabetes and Cardiovascular Disease Prevention
Status: ENROLLING_BY_INVITATION
Conditions: Cardiovascular Diseases|Type 2 Diabetes
Interventions: BEHAVIORAL: Health Dialogue Intervention|OTHER: Opportunistic Screening
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Prognostic Factors in Periampullary Tumors and Cysts
Status: RECRUITING
Conditions: Pancreas Cancer|Pancreas Neoplasm|Pancreas Cyst|Pancreatic Fistula|Pancreas Disease|Bile Duct Cancer|Periampullary Cancer|Surgery|Surgery--Complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of the Atkins Diet Versus a Low Fat Diet on Inflammation
Status: COMPLETED
Conditions: Cardiovascular Health|Obesity
Interventions: DIETARY_SUPPLEMENT: Low-Carbohydrate (Modified Atkins) Diet|DIETARY_SUPPLEMENT: Low-Fat (Heart Healthy) Diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immunological Effect of Increasing Doses of Natural Peptide
Status: UNKNOWN
Conditions: Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: 1 gram of a protein hydrolysate|DIETARY_SUPPLEMENT: 2 grams of a protein hydrolysate|DIETARY_SUPPLEMENT: 4 grams of a protein hydrolysate|DIETARY_SUPPLEMENT: 8 grams of a protein hydrolysate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transperineal Laser Ablation for Focal Treatment of Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer|Focal Laser Ablation|Transperineal Laser Ablation
Interventions: DEVICE: Echolaser X4 system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Analysis of the Effectiveness and Safety of Lorlatinib in Untreated ALK-Positive NSCLC Patients in a French Real-World Context
Status: NOT_YET_RECRUITING
Conditions: ALK+ Non-Small-Cell Lung Carcinoma
Interventions: DRUG: Lorlatinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes
Status: COMPLETED
Conditions: Schizophrenia|Prediabetic State
Interventions: DRUG: Semaglutide, 1.34 mg/mL|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Impact of Mindfulness on Patients' Experience of Osteopathic Manipulation
Status: COMPLETED
Conditions: Pain|Satisfaction, Patient
Interventions: BEHAVIORAL: Mindfulness Meditation|BEHAVIORAL: History of Osteopathy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Suture-mediated Closure System Following Endovascular Peripheral Arterial Procedures
Status: NOT_YET_RECRUITING
Conditions: Percutaneous Intervention Via Femoral Artery
Interventions: DEVICE: Tyknot® Suture-Mediated Closure System|DEVICE: Perclose® ProGlide Suture-Mediated Closure System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulmonary Nodule Detection: Comparison of an Ultra Low Dose vs Standard Scan.
Status: COMPLETED
Conditions: Lung Cancer|Smoking|Radiation Exposure
Interventions: DEVICE: Ultra low dose chest CT|DEVICE: Low dose chest CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids
Status: ACTIVE_NOT_RECRUITING
Conditions: Keloid
Interventions: DRUG: Botulinum toxin type A|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Clear Cell Renal Cell Carcinoma|Metastatic Kidney Carcinoma|Stage III Renal Cell Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7
Interventions: BIOLOGICAL: Aldesleukin|PROCEDURE: Computed Tomography|DRUG: Entinostat|RADIATION: Fludeoxyglucose F-18|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lithothamnion Species on Blood Lactate During Exhaustive Exercise in Trained Cyclists
Status: UNKNOWN
Conditions: Exercise-Induced Lactic Acidemia|Lactate Blood Increase
Interventions: DIETARY_SUPPLEMENT: Mineral Rich Algae|DIETARY_SUPPLEMENT: Orange flavoured water with maltodextrin as the placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Baricitinib in Participants From 2 Years to Less Than 18 Years Old With Juvenile Idiopathic Arthritis
Status: COMPLETED
Conditions: Juvenile Idiopathic Arthritis
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multidomain Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention
Status: COMPLETED
Conditions: Risk Behavior|Cognitive Decline
Interventions: BEHAVIORAL: Luci Coach Assisted Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Alemtuzumab in Autoimmune Inflammatory Neurodegeneration: Mechanisms of Action and Neuroprotective Potential
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Alemtuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Trabectedin (YONDELIS) in Patients With Locally Advanced or Metastatic Liposarcoma or Leiomyosarcoma
Status: COMPLETED
Conditions: Advanced or Metastatic Liposarcoma or Leiomyosarcoma
Interventions: DRUG: Trabectedin|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nationwide Research on the Rewilding of Kindergarten Yards
Status: RECRUITING
Conditions: Microbial Colonization|Atopic Dermatitis|Asthma in Children|Allergy|Cognitive Change|Respiratory Infection|Nature, Human
Interventions: OTHER: Biodiversity|OTHER: Playground equipment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Humanized Monoclonal Antibody Milatuzumab for Refractory Chronic Lymphocytic Leukemia (CLL)
Status: UNKNOWN
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Milatuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Intensity Interval Inspiratory Training Effect on Ventilatory Functions and Diaphragmatic Excursion in Forward Head Posture
Status: COMPLETED
Conditions: FHD
Interventions: DEVICE: Threshold Inspiratory muscle trainer|OTHER: posture correction exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Ondansetron for Bipolar Disorder and Alcohol Use Disorders
Status: COMPLETED
Conditions: Bipolar Disorder|Alcohol Use Disorder|Dual Diagnosis
Interventions: DRUG: Ondansetron|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Effects of Treatment in Patients With Recently Diagnosed Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: rosiglitazone|DRUG: metformin|DRUG: Anti-diabetic medications
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Intermediate- or High-Grade Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: DRUG: CHOP regimen|DRUG: carmustine|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: melphalan|DRUG: prednisone|DRUG: vincristine sulfate|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Before-after Comparison of Pharmacist Drug Therapy Management in Pediatric Hypertension
Status: COMPLETED
Conditions: Hypertension|Blood Pressure
Interventions: OTHER: Pharmacist Drug Therapy Management
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Improved Respiratory Infection by Consuming Lactoferrin Fortified a2 Growing up Formula in Children of 2 to 3 Year Old
Status: COMPLETED
Conditions: Respiratory Infection|Diarrheal Disease
Interventions: DIETARY_SUPPLEMENT: a2 growing up stage 3 formula puls lactoferrin supplement|DIETARY_SUPPLEMENT: Enfinitas growing up stage 3 formula
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19
Status: TERMINATED
Conditions: COVID 19|Coronavirus|Diabetes Mellitus, Type 2|Diabetes Mellitus|Glucose Metabolism Disorders|Metabolic Disease|Endocrine System Diseases|Dipeptidyl-Peptidase IV Inhibitors|Linagliptin|Severe Acute Respiratory Syndrome Coronavirus 2|Sars-CoV2|Hypoglycemic Agents|Respiratory Tract Diseases|Incretins|Hormones
Interventions: DRUG: Linagliptin 5 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Resistance and Aerobic Exercise in CIDP or MMN
Status: COMPLETED
Conditions: Chronic Inflammatory Demyelinating Polyneuropathy|Multifocal Motor Neuropathy
Interventions: OTHER: Resistance training|OTHER: Aerobic training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Combination Chemotherapy in Treating Patients With Previously Untreated Stage III or Stage IV Ovarian or Primary Peritoneal Cancer
Status: TERMINATED
Conditions: Ovarian Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: carboplatin|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Vertebral Augmentation With Kyphoplasty vs Nonsurgical Mgmt for Vertebral Body Compression Fractures
Status: WITHDRAWN
Conditions: Multiple Myeloma
Interventions: PROCEDURE: Vertebral Augmentation with Balloon Kyphoplasty|OTHER: Non-surgical Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endobarrier Treatment in Women With PCOS
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Interventions: DEVICE: Endobarrier treatment in PCOS|DRUG: clomiphene citrate treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women
Status: RECRUITING
Conditions: Infertility, Female|Anovulatory Infertility|Menopause|Amenorrhea
Interventions: BIOLOGICAL: Autologous PRP intra ovarian infusion|BIOLOGICAL: Autologous PFP intra ovarian infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy Study of the Antibody PAT-SM6 in Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Drug Safety
Interventions: BIOLOGICAL: Anti-GRP78 monoclonal IgM antibody PAT-SM6
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pertuzumab in Platinum-Resistant Low Human Epidermal Growth Factor Receptor 3 (HER3) Messenger Ribonucleic Acid (mRNA) Epithelial Ovarian Cancer (PENELOPE)
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Gemcitabine (Chemotherapy)|DRUG: Paclitaxel (Chemotherapy)|DRUG: Pertuzumab|DRUG: Placebo|DRUG: Topotecan (Chemotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: IMRT Plus Cisplatin Versus Conventional Radiotherapy Plus Cisplatin in Stage III-IV HNSCC
Status: COMPLETED
Conditions: Oral Cancer|Oropharynx Cancer|Hypopharynx Cancer
Interventions: PROCEDURE: IMRT 75 Gy|PROCEDURE: Conventional radiotherapy 70 Gy|DRUG: concomitant cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Immuno-therapy Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab or Nivolumab in Combination With Other Agents in Patients With Advanced Liver Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Nivolumab|DRUG: Sorafenib|DRUG: Ipilimumab|DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Telemedicine Outreach for Post Traumatic Stress in CBOCs
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: OTHER: Telemedicine Outreach for PTSD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Sympathetic Denervation in Metabolic Syndrome (Metabolic Syndrome Study)
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: PROCEDURE: Renal Denervation|DEVICE: EnligHTN™ Renal Denervation System.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery
Status: WITHDRAWN
Conditions: Shoulder Arthroscopy|Knee Arthroscopy
Interventions: DRUG: Sugar pill|DRUG: Gabapentin|DRUG: Clonidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of M1 and M2 Macrophages in Endometriotic Tissue of Women Affected by Endometriosis at Different Stages.
Status: COMPLETED
Conditions: Endometriosis
Interventions: DIAGNOSTIC_TEST: Evaluation of M1 and M2 macrophages by flow cytometry.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Vitamin D and Calcium on Bone in Pediatric HIV
Status: COMPLETED
Conditions: HIV Infection|Bone Mass
Interventions: DIETARY_SUPPLEMENT: cholecalciferol plus calcium carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunological Response to Intravesical BCG Therapy of Superficial Bladder Cancer by Prior Administration of RUTI®
Status: COMPLETED
Conditions: High-Risk Non-Muscle-Invasive Bladder Cancer
Interventions: DRUG: RUTI®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Avatrombopag for the Treatment of Chemotherapy-Induced Thrombocytopenia in Adults With Active Non-Hematological Cancers
Status: COMPLETED
Conditions: Chemotherapy-induced Thrombocytopenia
Interventions: DRUG: Avatrombopag|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Food Effect Study of Alisertib (MLN8237) in Participants With Advanced Solid Tumors or Lymphomas
Status: COMPLETED
Conditions: Advanced Solid Tumors|Lymphoma
Interventions: DRUG: Alisertib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Orange Juice Consumption and Glucose Metabolism and Antioxidative Status
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Orange juice with meals|DIETARY_SUPPLEMENT: Orange juice between meals|DIETARY_SUPPLEMENT: Sugar sweetened beverage between meals
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Scanadu Urine Device Validation Study Protocol
Status: UNKNOWN
Conditions: Urinary Tract Infections|Proteinuria|Ketone Urine|Hematuria|Glucose Intolerance
Interventions: DEVICE: Scanadu Urine Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Capecitabine Metronomic Chemotherapy Plus Aromatase Inhibitor for Postmenopausal Hormone Receptor Positive Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Capecitabine|DRUG: aromatase Inhibitors (AIs)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Trial of IRESSA, Cisplatin and Radiation Therapy for Patients With Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Cancer
Interventions: DRUG: ZD1839 (IRESSA)|DRUG: Cisplatin|PROCEDURE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Aquatic Exercise on Post-exercise Hypotension
Status: COMPLETED
Conditions: Hypertension|Aging|Obesity
Interventions: OTHER: LICE|OTHER: MICE|OTHER: HIIE|OTHER: Aquatic exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Selected Mesenchymal Stromal Cells to Reduce Inflammation in Patients With PSC and AIH
Status: ACTIVE_NOT_RECRUITING
Conditions: Cholangitis, Sclerosing|Hepatitis, Autoimmune
Interventions: BIOLOGICAL: Orbcel-C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of NK510 to Treat Osteosarcoma and Soft Tissue Sarcoma
Status: RECRUITING
Conditions: Osteosarcoma|Soft Tissue Sarcoma
Interventions: DRUG: NK510|DRUG: NK510
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrapartum Fever: Antibiotics Versus no Treatment
Status: WITHDRAWN
Conditions: Chorioamnionitis|Intrapartum Fever|Intra-amniotic Infection
Interventions: DRUG: Standard Antibiotic Treatment|OTHER: No Antibiotic Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of SHPL-49 Injection in Participants With Acute Ischemic Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke
Interventions: DRUG: 3 ampoules of SHPL-49 Injection|DRUG: 6 ampoules of SHPL-49 Injection|DRUG: 0.9% Sodium Chloride Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Pharmacokinetics of Filgotinib in Participants With Impaired Hepatic Function
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Filgotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thiamine Supplementation in Patients With Septic Shock
Status: WITHDRAWN
Conditions: Septic Shock|Shock, Septic|Lactic Acidosis|Thiamine Deficiency
Interventions: DRUG: Thiamine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Lesion Detection in Children With Magnetic Resonance Imaging (MRI)-Negative Partial Epilepsy Using Diffusion Tensor Imaging
Status: COMPLETED
Conditions: Localization-related Epilepsy|Partial Epilepsy
Interventions: PROCEDURE: Diffusion Tensor Imaging (DTI)|PROCEDURE: Magnetoencephalography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Use of Recombinant Human Lactoferrin in Long-Term Care Patients With Feeding Tubes With Clostridium Difficile.
Status: UNKNOWN
Conditions: Clostridium Difficile
Interventions: DRUG: recombinant human lactoferrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Phase 1 Study Investigating the Safety, Tolerability and Pharmacokinetics of KNX100 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer Study|Opioid-use Disorder
Interventions: DRUG: KNX100
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Safety and Effects on Lipids of FM-VP4 in Subjects With Primary Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Disodium Ascorbyl Phytostanol Phosphate (FM-VP4)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Effect of Combined Music and Taekwondo Training for Children With Autism Spectrum Disorder
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: OTHER: Taekwondo training with music therapy|OTHER: Taekwondo training alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of 40Hz Transcranial Stimulation in AICU on Incidence of Postoperative Delirium in Elderly Patients
Status: RECRUITING
Conditions: Postoperative Delirium|Anesthesia|Elderly
Interventions: DEVICE: 40Hz stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Testing Decision Making in Aging and Dementia for Autonomy Program in Nursing Homes
Status: ACTIVE_NOT_RECRUITING
Conditions: Dementia|Staff Attitude|Nurse's Role|Nursing Homes
Interventions: BEHAVIORAL: DIGNITY|BEHAVIORAL: Infection Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Remifentanil Effect-site Prediction by Algometry
Status: COMPLETED
Conditions: Conscious Sedation Failure During Procedure
Interventions: DRUG: Remifentanil 1 MG Injection [Ultiva]|DRUG: Midazolam 1 MG/ML Prefilled Syringe|DRUG: Saline solution|DEVICE: Algometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety Study of SYNT001 in Participants With Warm Autoimmune Hemolytic Anemia (WAIHA)
Status: TERMINATED
Conditions: Warm Autoimmune Hemolytic Anemia
Interventions: DRUG: ALXN1830
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis
Status: COMPLETED
Conditions: Degenerative Arthritis
Interventions: BIOLOGICAL: TissueGene-C(Low dose)|BIOLOGICAL: TissueGene-C(High dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of a Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation
Status: UNKNOWN
Conditions: Atrial Fibrillation
Interventions: DEVICE: Aegis Sierra Ligation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bortezomib, Fluorouracil, and Leucovorin Calcium in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: bortezomib|DRUG: fluorouracil|DRUG: leucovorin calcium|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Propofol+ Rocuronium+ Fentanyl 2 mcg/kg+ Inhalational Agent, Bupivacaine 0.125% + Fentanyl 5 mcg/ml|DRUG: Propofol+ Rocuronium+ Fentanyl + Inhalational|PROCEDURE: Open Pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED
Status: RECRUITING
Conditions: Persistent Corneal Epithelial Defect
Interventions: DRUG: KPI-012|DRUG: KPI-012 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Muscle Activity With Real-time Kinematics (M-MARK): A Novel Combination of Existing Technologies to Improve Arm Recovery Following Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: M-MARK
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: s Serratus Anterior Block for Perioperative Analgesia
Status: RECRUITING
Conditions: Mastectomy|Postoperative Pain
Interventions: PROCEDURE: Erector Spinae Plane Block|PROCEDURE: Serratus Anterior Plane Block|PROCEDURE: controll group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Topography-Guided LASIK to Treat Myopia and Hyperopia
Status: COMPLETED
Conditions: Myopia|Hyperopia
Interventions: DEVICE: T-CAT topography-guided LASIK treatment with the Allegretto Wave Eye-Q 400 Hz Excimer Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiosurgery Followed by Wedge Resection in Treating Patients With Early Stage Peripheral Non-small Cell Lung Cancer
Status: WITHDRAWN
Conditions: Recurrent Non-small Cell Lung Cancer|Stage IA Non-small Cell Lung Cancer|Stage IB Non-small Cell Lung Cancer
Interventions: RADIATION: stereotactic radiosurgery|PROCEDURE: therapeutic conventional surgery|OTHER: laboratory biomarker analysis|OTHER: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma and in Subjects With High-Risk Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: bb2121|DRUG: Lenalomide|DRUG: Talquetamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Status: COMPLETED
Conditions: Spinal Anesthesia
Interventions: DRUG: Placebo|DRUG: epinephrine 25|DRUG: Epinephrine 50|DRUG: epinephrine 100|DRUG: Epi 200
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Influence of Mucosa Tissue Thickness on Marginal Bone Loss of Implants With Smooth Collars
Status: COMPLETED
Conditions: Gingival Tissue
Interventions: DEVICE: Biohorizons Tapered Internal Implant, Laser-Lok, Resorbable Blast Textured (RBT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Adagloxad Simolenin/OBI-821 in Combination With TACE Therapy in HCC Patients With GALNT14-rs9679162-non-TT Genotype
Status: TERMINATED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: adagloxad simolenin/OBI-821|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Single Dose Phase I Trial of BI 201335 to Study Pharmacokinetics and Safety in Patients With Compensated Liver Cirrhosis
Status: COMPLETED
Conditions: Hepatitis C|Liver Cirrhosis
Interventions: DRUG: BI 201335
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Peripheral Blood Stem Cell Transplantation With Bone Marrow Transplantation for the Treatment of Serious Hematological Malignancies
Status: COMPLETED
Conditions: Blood Stem Cell Transplant
Interventions: PROCEDURE: Blood stem cell versus bone marrow transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adaptive Treatment for Acute Myeloid Leukemia Based on D14 MRD Results
Status: RECRUITING
Conditions: AML|MRD
Interventions: DRUG: Azacitidine|DRUG: Venetoclax|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Status: COMPLETED
Conditions: Chronic Oral Food Refusal
Interventions: DRUG: Amitriptyline|DRUG: Placebo|DRUG: Megestrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NeoVax With Nivolumab in Patients With Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Interventions: DRUG: Nivolumab|BIOLOGICAL: NeoVax|PROCEDURE: Core Needle Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT