pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: TOBacco STOP in Chronic Obstructive Pulmonary Disease-Trial - Study Protocol
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease|Smoking Cessation|Lung Diseases, Obstructive|Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: High-intensity smoking cessation intervention|DRUG: Low-intensity smoking cessation intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pepped on Pre-exposure Prophylaxis (PrEP): A Counseling and Problem-Solving PrEP Adherence Intervention for Stimulant Using Men Who Have Sex With Men (MSM).
Status: COMPLETED
Conditions: PrEP Uptake|Stimulant Abuse|Adherence, Medication
Interventions: BEHAVIORAL: Pepped on PrEP Package
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Study of Mitoxantrone Liposome and Azacitidine in the Treatment of R/R AITL
Status: RECRUITING
Conditions: Angioimmunoblastic T-cell Lymphoma
Interventions: DRUG: mitoxantrone liposome 16 and azacitidine|DRUG: mitoxantrone liposome 18 and azacitidine|DRUG: mitoxantrone liposome 20 and azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of the LUM Imaging System for Detection of Cancer to the Brain
Status: SUSPENDED
Conditions: Low Grade Glioma of Brain|Glioblastoma|Metastasis to Brain
Interventions: COMBINATION_PRODUCT: LUM Imaging System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Influence of Iron and Foliate Transporters on Bioavailability of These Micronutrients in the Organism
Status: COMPLETED
Conditions: Nutrition Disorders
Interventions: DIETARY_SUPPLEMENT: Folic acid and iron supplementation|DIETARY_SUPPLEMENT: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treatment of Skeletal Class III Malocclusion Using Orthodontic Removable Traction Appliance
Status: COMPLETED
Conditions: Class III Malocclusion
Interventions: DEVICE: Vacuum plate|DEVICE: Rapid maxillary expander|DEVICE: Class III elastics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tirofiban for Successful Endovascular Stroke Thrombectomy
Status: NOT_YET_RECRUITING
Conditions: Stroke, Acute Ischemic
Interventions: DRUG: Intraarterial and intravenous tirofiban|DRUG: Intraarterial and intravenous placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MKND-201 in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: (Part A) MKND-201|DRUG: Placebo|DRUG: (Part B) MKND-201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of SMR Neurofeedback on Insomnia in Patients With Benign Brain Tumors
Status: TERMINATED
Conditions: Benign Brain Tumor|Neurofeedback|Insomnia
Interventions: BEHAVIORAL: sensorimotor rhythm neurofeedback training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Astrocytoma, IDH-Mutant, Grade 2|Astrocytoma, IDH-Mutant, Grade 3
Interventions: OTHER: Questionnaire Administration|RADIATION: Radiation Therapy|DRUG: Telaglenastat Hydrochloride|DRUG: Temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HLT transfemOral Replacement of aortIc Valve Via transcatherteriZatiON
Status: COMPLETED
Conditions: Severe Aortic Stenosis|Aortic Valve Stenosis
Interventions: DEVICE: HLT Transcatheter Aortic Valve System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Positive Pressure During Bronchoscopy
Status: COMPLETED
Conditions: Acute Respiratory Failure With Hypoxia
Interventions: DEVICE: Noninvasive Positive Pressure Ventilation|DEVICE: CPAP valve (Boussignac)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cardiac Rest and Stress Metabolism in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Metabolic Cardiomyopathy|Metabolic Disturbance|Fatty Acid Oxidation Disorder
Interventions: OTHER: Surely observational based on disease state
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effectiveness of a Lung Health Promotion Program Based on the 5A Self Management Support Model.
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Disease
Interventions: BEHAVIORAL: breathing exercise, walking exercise and vaccination counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Paclitaxel Albumin-Stabilized Nanoparticle Formulation After Cisplatin-Based Chemotherapy and Surgery in Treating Patients With High-Risk Bladder Cancer
Status: WITHDRAWN
Conditions: Recurrent Bladder Urothelial Carcinoma|Stage IV Bladder Urothelial Carcinoma
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Paclitaxel Albumin-Stabilized Nanoparticle Formulation|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Trial of Seminal Vesicle-Sparing Prostatectomy and Nerve-Sparing Radical Prostatectomy in Men With Clinically Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: PROCEDURE: nerve-sparing radical prostatectomy|PROCEDURE: seminal vesicle-sparing radical prostatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Diacerein on Hand Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: diacerein|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy in Treating Patients With Advanced Bladder or Kidney Cancer
Status: COMPLETED
Conditions: Bladder Cancer|Transitional Cell Cancer of the Renal Pelvis and Ureter
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: doxorubicin hydrochloride|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Renal Oxygen Consumption, Insulin Sensitivity, and Daily Caloric Restriction in ADPKD
Status: RECRUITING
Conditions: Autosomal Dominant Polycystic Kidney
Interventions: BEHAVIORAL: Daily caloric restriction|OTHER: Standard advice control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pyloroplasty Versus No Pyloroplasty in Patients Undergoing Esophagectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophagectomy
Interventions: PROCEDURE: Esophagectomy|PROCEDURE: Pyloroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BMS-214662 in Treating Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: BMS-214662|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Telepsychiatry-based Culturally Sensitive Collaborative Treatment of Depressed Chinese Americans
Status: COMPLETED
Conditions: Depression
Interventions: BEHAVIORAL: Telepsychiatry-based Culturally Sensitive Collaborative Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)
Status: COMPLETED
Conditions: Hepatic Impairment|Hepatic Function
Interventions: DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alefacept (Amevive) With or Without Narrowband UVB Treatment in Patients With Psoriasis.
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Alefacept (drug)|PROCEDURE: Narrowband UVB phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Immuno, Reacto and Safety of Recombinant Hepatitis B Vaccine With or Without MPL in Healthy Older Adults
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Engerix™-B|BIOLOGICAL: Recombinant HBsAg with different concentrations of Aluminium Salts and/or MPL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reiki Effects on Heart Rhythm, Biochemistry and Cortisol Findings, and Anxiety
Status: COMPLETED
Conditions: Anxiety|Heart Diseases
Interventions: OTHER: Reiki|OTHER: Sham Reiki
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity
Status: RECRUITING
Conditions: Healthy Aging|Lifestyle-related Condition|Metabolic Diseases
Interventions: DIETARY_SUPPLEMENT: Nicotinamide Riboside (NR)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies
Status: COMPLETED
Conditions: Scabies
Interventions: DRUG: Permethrin Cream, 5%|DRUG: Elimite™ Cream (permethrin) 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Strategy to Prevent the Recurrence of Dental Disease in Children Receiving Dental Treatment With General Anesthesia
Status: COMPLETED
Conditions: Caries
Interventions: BEHAVIORAL: verbal education|BEHAVIORAL: verbal education, visual aids, and motivational interviewing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Light Therapy in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Sleep Disorder|Circadian Rhythm Disorders
Interventions: DEVICE: Bright light box|DEVICE: Dim Light box
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vonoprazan-based Dual and Triple Therapies for H. Pylori Eradication
Status: COMPLETED
Conditions: Gastritis Associated With Helicobacter Pylori
Interventions: DRUG: vonoprazan 20 mg bid|DRUG: Amoxicillin 500 mg tid|DRUG: Amoxicillin 750 mg bid|DRUG: Clarithromycin 200 mg bid|DRUG: Metronidazole 250 mg bid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fractional Exhaled Nitric Oxide and CRP Levels in Egyptian Patients With Obstructive Sleep Apnea Syndrome
Status: COMPLETED
Conditions: OSA
Interventions: DIAGNOSTIC_TEST: Fractional exhaled nitric oxide and CRP levels
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Usefulness of Protein-enriched Infant Formula in Pediatric Intensive Care.
Status: UNKNOWN
Conditions: Protein-Energy Malnutrition
Interventions: OTHER: Protein-enriched nutrition|DIETARY_SUPPLEMENT: High Protein-enriched Nutrition|OTHER: Standard Enteral Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Postoperative Pain and Bacterial Load Reduction With ProTaper Ultimate Versus ProTaper Gold Rotary Systems
Status: UNKNOWN
Conditions: Post Operative Pain
Interventions: OTHER: Instrument Design
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dexcom Continuous Glucose Monitoring in Long-term Care
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DEVICE: Dexcom G6 CGM with GTS|DIAGNOSTIC_TEST: POC Blood Glucose Test + Blinded CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Genetically Risk-Stratified Venetoclax, Ibrutinib, Rituximab (± Navitoclax) in Relapsed/Refractory Mantle Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Mantle Cell Lymphoma Refractory
Interventions: DRUG: Ibrutinib|DRUG: Venetoclax|DRUG: Navitoclax|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination of Triple Negative Breast Cancer Patients
Status: COMPLETED
Conditions: Triple Negative Breast Cancer|Breast Neoplasms
Interventions: BIOLOGICAL: P10s-PADRE with MONTANIDE™ ISA 51 VG|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Placebo- and Paroxetine-controlled Study of the Efficacy, Safety and Tolerability of Agomelatine (25 or 50 mg) in the Treatment of Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Agomelatine|DRUG: paroxetine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Impact of a 13-valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: 13-valent Pneumococcal Conjugate Vaccine|BIOLOGICAL: 7 valent pneumococcal conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Factors Affecting The Recurrence Of Acute Cholecystitis After Treatment With Percutaneous Cholecystostomy
Status: COMPLETED
Conditions: Acute Cholecystitis|Percutaneous Cholecystostomy|Recurrence
Interventions: PROCEDURE: percutaneous cholecystostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single-Ascending-Dose Safety/Tolerability of NP001 in Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DRUG: NP001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Recombinant Pneumococcal Protein Vaccine
Status: ACTIVE_NOT_RECRUITING
Conditions: Pneumonia|Respiratory Tract Diseases|Respiratory Tract Infections
Interventions: BIOLOGICAL: PBPV|BIOLOGICAL: PPV23
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Efficacy and Safety of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
Status: COMPLETED
Conditions: Colitis, Ulcerative
Interventions: DRUG: Guselkumab Dose 1|DRUG: Guselkumab Dose 2|DRUG: Golimumab Dose 1|DRUG: Golimumab Dose 2|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modified Ramped Position for Intubation of Obese Females.
Status: COMPLETED
Conditions: Obesity|Anesthesia
Interventions: OTHER: Modified ramped position|OTHER: Ramped position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Trial With Two Physical Therapy Protocols After Breast Cancer Surgery and Immediate Reconstruction
Status: COMPLETED
Conditions: Breast Neoplasms
Interventions: OTHER: Alloplastic free ROM|OTHER: Alloplastic limited ROM|OTHER: Oncoplastic free ROM|OTHER: Oncoplastic limited ROM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD
Status: COMPLETED
Conditions: Autosomal Dominant Polycystic Kidney|ADPKD
Interventions: DRUG: Tesevatinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of CK-1827452 Infusion in Stable Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: Placebo|DRUG: Placebo|DRUG: CK-1827452|DRUG: Placebo|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452|DRUG: CK-1827452
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Two Dose Levels of Daunorubicin and Between One vs. Two Induction Cycles for Adult Patients With AML
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute
Interventions: DRUG: study part 1 - dose daunorubicin|PROCEDURE: induction cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Association Splitting" in Obsessive-Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: BEHAVIORAL: "association splitting"|BEHAVIORAL: cognitive remediation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Glucose-Insulin-Potassium Infusion in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Aortic Stenosis|Coronary Heart Disease|Heart Failure
Interventions: DRUG: Glucose-insulin-potassium|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: trazodone/gabapentin 2.5/25 mg|DRUG: trazodone/gabapentin 5/50 mg|DRUG: trazodone/gabapentin 10/100|DRUG: Gabapentin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brown Adipose Tissue Activation and Energy Expenditure by Capsinoids Stimulation With Trimodality Imaging Using 18-FDG-PET, Fat Fraction MRI and Infrared Thermography
Status: COMPLETED
Conditions: Brown Adipose Tissue
Interventions: OTHER: Capsinoids|OTHER: Cold Stimulus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase I Study of Continuous Administration of Salvianolic Acid A Tablet
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: salvianolic acid A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Nivolumab in Combination With Decitabine and Venetoclax in Patients With Newly Diagnosed TP53 Gene Mutated Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Decitabine|BIOLOGICAL: Nivolumab|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label, Single Dose Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression
Status: RECRUITING
Conditions: Treatment Resistant Depression
Interventions: DRUG: BPL-003
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gleevec and Gemzar in Patients With Epithelial Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer|Primary Peritoneal Cancer
Interventions: DRUG: imatinib mesylate by mouth|DRUG: Gemcitabine Intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safe and Fast Radial Hemostasis Using Synergistic Strategies: SAFE & FAST Trial
Status: RECRUITING
Conditions: Cardiovascular Diseases|Bleeding|Arterial Puncture|Catheter Complications|Occlusion of Artery
Interventions: DRUG: Heparin|DEVICE: Terumo Radial Band|DEVICE: Vaosband
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.
Status: NOT_YET_RECRUITING
Conditions: Sepsis|Hypoperfusion|Hyperlactatemia
Interventions: DRUG: Dobutamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Specifically Adapted Judo-based Training Program on Risk Factors for Falls Among Adults
Status: COMPLETED
Conditions: Accidental Fall|Fall Injury|Work-related Injury|Work Accident
Interventions: BEHAVIORAL: Active Comparator: Participants in 10 week Judo Inspired Exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Clinical Post Market Clinical Follow-up (PMCF) on Peripheral Arteries Treated With SeQuent® Please Over The Wire (OTW)
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Occlusive Disease
Interventions: PROCEDURE: drug coated balloon angioplasty|DEVICE: SeQuent® Please OTW Paclitaxel Coated Balloon Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FAPI and FDG PET/MRI in Diagnosis and Therapy Prediction of Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Urinary Bladder Neoplasms
Interventions: PROCEDURE: imaging examinations:FAPI PET/MRI, FDG PET/MRI, MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose
Status: COMPLETED
Conditions: Drug-Induced Acute Liver Injury
Interventions: DRUG: N-acetylcysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Shoulder Function
Status: COMPLETED
Conditions: Rehabilitation|Neck Pain|Shoulder Pain|Scapular Dyskinesis|Muscle Activation
Interventions: BEHAVIORAL: Training|BEHAVIORAL: Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Patients Undergoing Non-emergent Coronary Angiography
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: stop ace-i/arb 24 h before procedure and restarted 24 hours after the procedure|DRUG: ACE/ARB stopped 24 hours before procedure and start immediately after
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Drug to Prevent Pneumonia in the Tube Fed
Status: TERMINATED
Conditions: Pneumonia|Neurological Dysphagia
Interventions: DRUG: Angiotensin converting enzyme inhibitor (Lisinopril)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases
Status: RECRUITING
Conditions: Brain Metastases|HR+ Metastatic Breast Cancer
Interventions: RADIATION: Stereotactic Radiosurgery (SRS)|DRUG: Abemaciclib|DRUG: Endocrine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prediction of Inter-individual Differences in the Response to Morphine Versus Milnacipran in Patients With Sciatica
Status: UNKNOWN
Conditions: Neuropathic Pain
Interventions: DRUG: Morphine|DRUG: Milnacipran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Radical Extent of Lymphadenectomy of LAparoscopic Right Colectomy for Colon Cancer(RELARC).
Status: UNKNOWN
Conditions: Colon Cancer
Interventions: PROCEDURE: D2 radical operation|PROCEDURE: Complete mesocolic excision (CME)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgery Treatment of Type 2 Diabetes Mellitus Patients With Grade 1 Obesity and Overweight
Status: UNKNOWN
Conditions: Diabetes Mellitus|Obesity|Overweight
Interventions: PROCEDURE: Duodenal Ileal Interposition with Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Erector Spinae Plane Block Versus Intrathecal Morphine on Post-Cesarean Delivery Analgesia
Status: UNKNOWN
Conditions: Cesarean Section Complications
Interventions: PROCEDURE: Erector Spinae Plane Block|DRUG: Intrathecal morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease
Status: RECRUITING
Conditions: Inflammatory Bowel Diseases|Ulcerative Colitis|Crohn Disease
Interventions: BEHAVIORAL: Comprehensive Self-Management Intervention|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of the Effectiveness of Intradialytic Core Stabilization and Aerobic Exercise in Hemodialysis Patients
Status: COMPLETED
Conditions: Hemodialysis Complication
Interventions: OTHER: exercıse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Study the Efficacy and Safety of Stempeucel® in Patients With CLI Due to Buergers Disease
Status: WITHDRAWN
Conditions: Critical Limb Ischemia Due to Buerger's Disease
Interventions: BIOLOGICAL: Stempeucel(R)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine and Platinol Followed by Pemetrexed and Gemcitabine in Patients With Advanced or Metastatic Bladder Cancer
Status: COMPLETED
Conditions: Carcinoma, Transitional Cell
Interventions: DRUG: Pemetrexed|DRUG: Gemcitabine|DRUG: Platinol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Follow-up at School-age of Children Who Participated in the Efficacy Study of Nitric Oxide for Premature Infants
Status: COMPLETED
Conditions: Prematurity, Respiratory Distress Syndrome,Hypoxemia
Interventions: DRUG: Inhaled nitric oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Sequenced Therapies for Comorbid and Primary Insomnias
Status: COMPLETED
Conditions: Insomnia Comorbid to Psychiatric Disorder|Primary Insomnia
Interventions: BEHAVIORAL: Behavioral Insomnia Therapy|DRUG: Zolpidem|DRUG: Trazodone|BEHAVIORAL: Cognitive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Resilience Promotion Program for Parents of Children With Cancer
Status: COMPLETED
Conditions: Parents of Children With Cancer
Interventions: OTHER: Resilience promotion program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Primary Molars Restorations With Encapsulated or Hand-Mixed Glass Ionomer: Clinical Trial
Status: COMPLETED
Conditions: Dental Caries
Interventions: PROCEDURE: Restoration with hand-mixed material|PROCEDURE: Restoration with Encapsulated material|DEVICE: Encapsulated glass ionomer cement (EQUIA - GC Corp).|DEVICE: powder-liquid glass ionomer cement (Fuji IX - GC Corp)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transcendental Meditation in Veterans and First Responders With PTSD
Status: RECRUITING
Conditions: PTSD
Interventions: BEHAVIORAL: Transcendental Meditation (TM)|BEHAVIORAL: Present Centered Therapy (PCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anakinra, COVID-19, Cytokine Storm
Status: WITHDRAWN
Conditions: Covid19|Cytokine Storm|Mechanical Ventilation Complication
Interventions: DRUG: Anakinra|DRUG: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics Study of Human Monoclonal Antibody (FGI-101-1A6)
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: FGI-101-1A6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Biomarker Evaluation in Advanced Stage Cervical Cancer by an International Working Group. Tumor Stages (1B1 - 4)
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: PROCEDURE: Tumor biopsies|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of the Kinetics of Lymphoid Cells in Patients With Monoclonal B-cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL) and Healthy Volunteers
Status: COMPLETED
Conditions: Lymphoma, Mantle-cell|CLL (Chronic Lymphocytic Leukemia)|Monoclonal B-Cell Lymphocytosis|Healthy Volunteers|Small Lymphocytic Lymphoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Two-week Crossover Evaluation of Two Hand Antiseptic Products on Skin Condition in Healthy Human Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Avagard|DRUG: Purell Surgical Scrub
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Basket Study of Leronlimab (PRO 140) in Patients With CCR5+ Locally Advanced or Metastatic Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumor, Adult
Interventions: DRUG: Leronlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
Status: RECRUITING
Conditions: NLRC4-GOF, AIFEC (Autoinflammation With Infantile Enterocolitis), XIAP Deficiency, CDC42 Mutations
Interventions: BIOLOGICAL: MAS825|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Suitable Schedule of Docetaxel,Anthracycline and Cyclophosphamide in Adjuvant Therapy of Beast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms|Adjuvant|Chemotherapy
Interventions: DRUG: Docetaxel, Doxorubicin or Epirubicin, Cyclophosphamide|DRUG: Docetaxel, Doxorubicin or Epirubicin, Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Enobosarm (GTx-024) in Postmenopausal Women With Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DRUG: GTx 024|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: FOLFOX regimen|DRUG: fluorouracil|DRUG: gefitinib|DRUG: leucovorin calcium|DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Assessment Study of Three Different Fasting Plasma Glucose Targets in Chinese Patients With Type 2 Diabetes Mellitus (BEYOND III/FPG GOAL)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: INSULIN GLARGINE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Palmar Cooling on Repeated Sprinting Ability
Status: NOT_YET_RECRUITING
Conditions: Exercise Induced Fatigue
Interventions: DEVICE: Palmar Cooling|DEVICE: Placebo Palmar Cooling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: UCLA Health Patient Health Maintenance Text Reminder
Status: ACTIVE_NOT_RECRUITING
Conditions: Health Maintenance|Diabetes|Cancer
Interventions: BEHAVIORAL: Reminder of preventive care measures|BEHAVIORAL: Persuasion via anecdote|BEHAVIORAL: Behavioral: Action prompt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Biomarkers Associated With Response to Subsequent Therapies in Subjects With HER2-Positive Metastatic Breast Cancer
Status: TERMINATED
Conditions: Neoplasms, Breast
Interventions: DRUG: Lapatinib|BIOLOGICAL: Trastuzumab|DRUG: Aromatase Inhibitors (AIs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Diuretic-based With Non-diuretic Based Hypertension Therapy Using Echocardiographic Measures
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Diuretic-Based or Non-Diuretic Based Hypertension Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1/1b Study of TRU-016 in Patients With Previously Treated CLL or Select Subtypes of Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia (CLL)|Non-Hodgkin's Lymphoma (NHL)
Interventions: DRUG: TRU-016 (anti-CD37 protein therapeutic)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Analgesic Effect of Different Local Anesthetics in Interscalene Nerve Block for Shoulder Surgery
Status: COMPLETED
Conditions: Other Peripheral Nerve Disease
Interventions: DRUG: Ropivacaine 0.75%|DRUG: Levobupivacaine 0.5%|DRUG: Levobupivacaine 0.5% + epinephrin 1/200000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin in Type 1 Diabetes
Status: COMPLETED
Conditions: Fasting Glucose|Glucose Excursion|Glycemic Control
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: propofol group|DRUG: sevoflurane group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: NVP-1805 Compared to Coadministration of NVP-1805-R1 With NVP-1805-R2 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: NVP-1805|DRUG: NVP-1805-R1and NVP-1805-R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy and Safety of Sandostatin LAR at High Dose or in Combination Either With GH-receptor Antagonist or Dopamine-agonist in Acromegalic Patients
Status: COMPLETED
Conditions: Acromegaly
Interventions: DRUG: Sandostatin LAR|DRUG: pegvisomant|DRUG: cabergoline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Intervention for Transgender/Nonbinary Young Adults' Experiences With Alcohol and Romantic Relationships
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use, Unspecified|Relationship, Social|Depression, Anxiety|Transgenderism
Interventions: BEHAVIORAL: Whole Selves
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of the Effectiveness of the Combined Psychological Resilience and Self-efficacy Intervention for Improving Resilience and Self-efficacy and Reducing Anxiety and Depression of Oesophageal Cancer Surgery Patients
Status: NOT_YET_RECRUITING
Conditions: Esophageal Cancer
Interventions: OTHER: The combined psychological resilience and self-efficacy intervention|OTHER: The mindfulness intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Magnesium Versus Prochlorperazine Versus Metoclopramide for Migraines
Status: COMPLETED
Conditions: Migraine|Headache
Interventions: DRUG: Magnesium Sulfate|DRUG: Metoclopramide 10mg|DRUG: Prochlorperazine (Compazine) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative PK, Safety, Tolerability, Immunogenicity, and PD Profile Study of TUR03 and Soliris in Healthy Participants
Status: RECRUITING
Conditions: Healthy
Interventions: DRUG: Soliris 300 MG in 30 ML Injection|DRUG: TUR03 300 MG in 30 ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Adhesion Quality and Irritation of an Alternate Second Generation Estradiol Transdermal System
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Estradiol Transdermal System Placebo - Alternate Adhesive|DRUG: Estradiol Transdermal System Placebo - Current Adhesive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Validity of HER2-amplified Circulating Tumor Cells to Select Metastatic Breast Cancer Considered HER2-negative for Trastuzumab-emtansine (T-DM1) Treatment.
Status: COMPLETED
Conditions: Metastatic Breast Cancer, HER2 Negative Primary Tumor
Interventions: DRUG: Trastuzumab - Emtansine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Metabolism and Pharmacokinetics of [14C]-BIBR 953 ZW After Administration of Single Doses of [14C]-BIBR 953 ZW Intravenously or [14C]-BIBR 1048 Oral Solution in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBR 953 ZW Intravenously|DRUG: BIBR 1048 Oral Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Lymphoma
Interventions: BIOLOGICAL: RevM10 gene|BIOLOGICAL: RevM10/polAS gene|PROCEDURE: in vitro-treated peripheral blood stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Online Multi-component Psychological Intervention for Prevention of Grief Disorder Due to COVID-19
Status: COMPLETED
Conditions: Grief|Anxiety|Depression|Sleep Disturbance|Quality of Life
Interventions: BEHAVIORAL: Online Intervention Grief COVID-19
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of BIA 2-093 on the Steady-state Pharmacokinetics of Digoxin
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: BIA 2-093|DRUG: Placebo|DRUG: Digoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab Plus Bacille Calmette-Guerin (BCG) in Patients With Non-muscle Invasive Bladder Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Avelumab|BIOLOGICAL: BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CAUDAL BUPIVACAINE VERSUS INTRAVENOUS MORPHINE ON TIME TO FIRST ANALGESIC REQUIREMENT
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: DRUG: caudal bupivacaine|DRUG: intravenous morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
Status: RECRUITING
Conditions: Delirium|Cognitive Dysfunction|Cognition Disorder|Neurocognitive Disorders|Mental Disorders|Confusion|Neurobehavioral Manifestations|Neurologic Manifestations|Nervous System Diseases|Signs and Symptoms|Dexmedetomidine|Hypnotics and Sedatives|Central Nervous System Depressants|Physiological Effects of Drugs|Analgesics, Non-Narcotic|Analgesics|Molecular Mechanisms of Pharmacological Action
Interventions: DRUG: Dexmedetomidine Hydrochloride Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Incisional Negative Pressure Therapy to Prevent Animal Induced Wound Infection
Status: NOT_YET_RECRUITING
Conditions: Injury Caused by Animal Bites|Wound Infection
Interventions: DEVICE: incisional negative pressure wound technology
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis
Status: COMPLETED
Conditions: Desmoid|Desmoid Fibromatosis of Skin|Desmoid Neoplasm of Chest Wall|Desmoid Tumor Caused by Somatic Mutation|Aggressive Fibromatoses|Fibromatosis Desmoid|Desmoid Fibromatosis
Interventions: PROCEDURE: Drug Eluting Bead Embolization (DEB) for Desmoid Fibromatosis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT