pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impairment of Gastric Emptying During Acute Phase of Myocardial Infarction. Impact on Oral Antiplatelet Treatment Efficacy. The GASTRIM Study.
Status: COMPLETED
Conditions: Impairment of Gastric Emptying|Acute Phase of Myocardial Infarction
Interventions: DRUG: Paracetamol concentration time curve from 0 to 120 min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Double-blind, Double-dummy, Multicenter, Randomized Study of the Efficacy and Tolerability of Valdecoxib 40 mg Versus Rofecoxib 50 mg in Treating the Symptoms of Ankle Sprain
Status: TERMINATED
Conditions: Acute Pain
Interventions: DRUG: valdecoxib|DRUG: rofecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Clinical Trial of a Phakic Implantable Collamer® Lens (ICL)
Status: COMPLETED
Conditions: Myopia|Myopic Astigmatism
Interventions: DEVICE: EVO/EVO+ Visian ICL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-75229414 for Metastatic Castration-resistant Prostate Cancer Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostatic Neoplasms
Interventions: DRUG: JNJ-75229414|DRUG: Bridging Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: Meloxicam|DRUG: Aceclofenac|DRUG: Tramadol Hydrochloride Plus Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2, Open-Label, Dose-Escalation, Safety Study of INCAGN01949 in Subjects With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Advanced Malignancies|Metastatic Cancer
Interventions: DRUG: INCAGN01949
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation Of Remote Monitoring With Direct Alerts To Reduce Time From Event To Clinical Decision
Status: COMPLETED
Conditions: The Patient Meets ACC/AHA/ESC Guidelines for Implantable Cardioverter Defibrillator (ICD) or Cardiac Resynchronization Therapy (CRT-D) Device
Interventions: DEVICE: Implantation of an ICD/CRT-D device|DEVICE: Merlin.NET PCN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect Of Mesenchymal Stem Cells Transfusion on the Diabetic Peripheral Neuropathy Patients .
Status: COMPLETED
Conditions: Diabetic Peripheral Neuropathy
Interventions: GENETIC: mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating the Safety and Efficacy of PTX-022 (QTORIN Sirolimus) in the Treatment of Microcystic Lymphatic Malformations
Status: COMPLETED
Conditions: Microcystic Lymphatic Malformation
Interventions: DRUG: PTX-022
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adapting Mental Health Interventions for War-Affected Youth Through Employment Programs
Status: COMPLETED
Conditions: Anxiety Disorder/Anxiety State|Depressive Disorder/Psychology|Social Problems/Psychology|Violence, Non-accidental
Interventions: BEHAVIORAL: YRI|OTHER: Income generating activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Implementation of Uterine Fibroid Option Grid Patient Decision Aids Across Five Organizational Settings
Status: COMPLETED
Conditions: Uterine Fibroid
Interventions: OTHER: Uterine Fibroid Option Grid encounter patient decision aid (text only)|OTHER: Uterine Fibroid Option Grid encounter patient decision aid (text + Pictures)|OTHER: Uterine Fibroid Option Grid encounter patient decision aid (online)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension
Status: COMPLETED
Conditions: Pregnancy, High Risk|Pre-Eclampsia|Hypertension|Hypertension, Pregnancy-Induced
Interventions: OTHER: Self-Monitoring of Blood Pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of CABG Related Bleeding Complications in Patients Treated With Ticagrelor or Clopidogrel
Status: COMPLETED
Conditions: Blood Loss, Surgical|Ticagrelor|Clopidogrel
Interventions: DRUG: Ticagrelor 180mg|DRUG: Clopidogrel 75mg
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Rett Syndrome Registry
Status: RECRUITING
Conditions: Rett Syndrome|Rett Syndrome, Atypical|Genetic Disease|Genetic Diseases, X-Linked|Intellectual Disability|Neurobehavioral Manifestations|Neurologic Manifestations|Neurologic Disorder|Neurodevelopmental Disorders|Nervous System Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Adductor Canal Block and Recovery After Total Knee Replacement Surgery
Status: COMPLETED
Conditions: Total Knee Arthroplasty
Interventions: DRUG: Adductor Canal Block|DRUG: Adductor Canal Block with Morphine|DRUG: Local Infiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Articaine vs Dexmedetomidine Supplemented Articaine
Status: COMPLETED
Conditions: Renal Failure
Interventions: DRUG: Articaine|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block Impact on Quality of Recovery After Lumbar Spinal Decompression
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacain
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Dietary Nitrate on Time Trial Performance in Swiss Paracycling Athletes
Status: COMPLETED
Conditions: Exercise Nutritional Physiology
Interventions: DIETARY_SUPPLEMENT: beetroot juice|DIETARY_SUPPLEMENT: sodium nitrate|DIETARY_SUPPLEMENT: water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers
Status: COMPLETED
Conditions: Healthy|Dry Eye
Interventions: DEVICE: MINI MONOKA canalicular stent, 10 mm|DEVICE: MINI MONOKA canalicular stent, 20 mm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy
Status: COMPLETED
Conditions: Hypertensive Anal Canal
Interventions: PROCEDURE: lateral internal sphincterotomy (LIS)|DRUG: Glycerin trinitrate (GTN)|DRUG: botulinum toxin injection (BTX A)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: En Pareja: A Latino Couples Intervention to Help Expectant Fathers Quit Smoking
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: couple-based counseling for smoking cessation plus self-help smoking cessation guide|BEHAVIORAL: Guia -a self help smoking cessation guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial
Status: TERMINATED
Conditions: Pain|Cerebral Palsy, Spastic
Interventions: DRUG: Dysport®|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Provide Initial Evidence of Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy to Support the Pivotal CT-P10 Therapeutic Equivalence Trial
Status: TERMINATED
Conditions: Diffuse Large B-Cell Lymphoma
Interventions: BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BeFluBu vs FluBuRux Conditioning in Haploidentical HCT
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Biphenotypic Acute Leukemia|Lymphoblastic Lymphoma|Myeloproliferative Neoplasm|Myelodysplastic Syndromes
Interventions: DRUG: Bendamustine Hydrochloride|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Adults to Evaluate the Bioavailability of Two Test Tablet Formulations of ABT-450
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ABT-450|DRUG: ritonavir|DRUG: ABT-450
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Gemcitabine and Hodgkin's Disease Chemotherapy Followed by Peripheral Blood Stem Cell Rescue for Hodgkin's Disease
Status: COMPLETED
Conditions: Hodgkin Disease|Hodgkin's Lymphoma|Lymphoma
Interventions: DRUG: Gemcitabine|DRUG: Vinorelbine|DRUG: Carmustine|DRUG: Etoposide|DRUG: Cyclophosphamide|PROCEDURE: Autologous HCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin in Youth: N-of-1 Trials in a Stimulant-treated Attention Deficit Hyperactivity Disorder (ADHD) Population
Status: WITHDRAWN
Conditions: Attention Deficit/Hyperactivity Disorder|Initial Insomnia
Interventions: DIETARY_SUPPLEMENT: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy/Safety of Valsartan Plus Amlodipine and Amlodipine Alone in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan/amlodipine 80/5 mg|DRUG: Amlodipine 5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Utilising Data From European Union (EU) National Multiple Sclerosis (MS) Registries to Assess the Incidence of Anti-Natalizumab Antibody Among Participants Who Receive Subcutaneous Administration of Natalizumab for Treatment of Relapsing-remitting Multiple Sclerosis (RRMS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Natalizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effective Postoperative Pain Relief After Laparoscopic Cholecystectomy With TENS
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DEVICE: TENS (transcutaneous electrical nerve stimulation)|DRUG: iv opioid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas
Status: ACTIVE_NOT_RECRUITING
Conditions: Ewing Sarcoma|Myxoid Liposarcoma|Sarcoma,Soft Tissue|Desmoplastic Small Round Cell Tumor|Extraskeletal Myxoid Chondrosarcoma|Angiomatoid Fibrous Histiocytoma|Clear Cell Sarcoma|Primary Pulmonary Myxoid Sarcoma|Myoepithelial Tumor|Sclerosing Epithelioid Fibrosarcoma|Fibromyxoid Tumor
Interventions: DRUG: Seclidemstat|DRUG: Cyclophosphamide|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Criteria for Lymph Node Sorting for Pathological Examination in Gastric Cancer
Status: UNKNOWN
Conditions: Lymph Node Metastases|Gastric Cancer|Exanimation
Interventions: PROCEDURE: lymph node sorting for pathological examination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women With Dyspareunia
Status: COMPLETED
Conditions: Vulvovaginal Atrophy
Interventions: DRUG: WC3011 Estradiol Vaginal Cream|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Triferic (Ferric Pyrophosphate Citrate) Administered Intravenously to Healthy Adult Volunteers
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DRUG: Triferic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure
Status: RECRUITING
Conditions: Heart Failure NYHA Class II|Heart Failure NYHA Class III
Interventions: DEVICE: Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download|OTHER: Medication intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomised Study Comparing Three Chemotherapy Regimens in Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cisplatin, Ifosfamide, Gemcitabine|DRUG: Ifosfamide, Gemcitabine|DRUG: Cisplatin, docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of SPARC1613 and reference1613 in Subjects With Locally Recurrent or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Recurrent or Metastatic Breast Cancer
Interventions: DRUG: SPARC1613|DRUG: Reference1613
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Brief Alcohol Interventions With a Behavioral Economic Supplement
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Brief Motivational Intervention (BMI)|BEHAVIORAL: Substance-Free Activity Session (SFAS)|BEHAVIORAL: Relaxation Session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Data-based High Simulation of Bronchoscopy Operations in Preoperative Bronchoscopy Informed Consent
Status: NOT_YET_RECRUITING
Conditions: Bronchoscopy
Interventions: OTHER: AI-based informed consent|OTHER: Standard informed consent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Nebula Study - Screener Apps and HSAT vs. PSG Comparison
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DIAGNOSTIC_TEST: PSG|DIAGNOSTIC_TEST: Home Sleep Apnea Test with FDA cleared devices|OTHER: Non-Contact Screening App
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effects of Subanesthetic Concentrations of Nitrous Oxide - 1
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: 20% N2O|DRUG: 30% N2O|DRUG: 40% N2O
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Normoxemic Versus Hyperoxemic Extracorporeal Oxygenation in Patients Supported by Veino-arterial ECMO for Cardiogenic Shock
Status: RECRUITING
Conditions: Cardiogenic Shock|Extracorporeal Membrane Oxygenation
Interventions: DRUG: Oxygen gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Comparing Moxifloxacin Versus Levofloxacin Plus Metronidazole In Uncomplicated Pelvic Inflammatory Disease
Status: COMPLETED
Conditions: Pelvic Inflammatory Disease
Interventions: DRUG: Moxifloxacin (Avelox, BAY12-8039)|DRUG: Levofloxacin & Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Targeted Temperature Management Duration on Thrombin Function in Cardiac Arrest Patients
Status: NOT_YET_RECRUITING
Conditions: Targeted Temperature Management|Cardiac Arrest|Thrombin Function|Treatment Duration
Interventions: PROCEDURE: Target Temperature Management Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sleep in Osteoarthritis Project
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Osteoarthritis
Interventions: BEHAVIORAL: Cognitive behavioral therapy (CBT) for insomnia|BEHAVIORAL: Behavioral desensitization treatment for insomnia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study of HM12470 in Type 1 and Type 2 Diabetes Mellitus
Status: UNKNOWN
Conditions: Type1 Diabetes Mellitus|Type2 Diabetes Mellitus
Interventions: BIOLOGICAL: HM12470
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remote Ischemic Postconditioning on Postoperative Renal Dysfunction in Patients Undergoing Valvular Heart Surgery
Status: COMPLETED
Conditions: Valvular Heart Disease Patients
Interventions: PROCEDURE: remote ischemic postconditioning|PROCEDURE: valvular surgery with bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women
Status: COMPLETED
Conditions: Diphtheria-Tetanus-acellular Pertussis Vaccines
Interventions: BIOLOGICAL: Boostrix™|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks
Status: UNKNOWN
Conditions: Adenocarcinoma of the Rectum|Adenocarcinoma|Adenocarcinoma, Mucinous|Carcinoma|Neoplasms, Glandular and Epithelial|Neoplasms by Histologic Type|Neoplasms|Neoplasms, Cystic, Mucinous, and Serous|Colorectal Neoplasms|Intestinal Neoplasms|Gastrointestinal Neoplasms|Digestive System Neoplasms|Neoplasms by Site|Digestive System Diseases|Gastrointestinal Diseases|Intestinal Diseases|Rectal Diseases
Interventions: OTHER: Patients who have surgery at 12 weeks after radiotherapy/chemoradiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Multi-site Double-blind Placebo-controlled Trial of Memantine Versus Placebo in Children With Autism (MEM)
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Schemes of Cryosurgery and Imiquimod Combination Treatment for Basal Cell Carcinoma
Status: COMPLETED
Conditions: Basal Cell Carcinoma
Interventions: PROCEDURE: Immunocryosurgery|PROCEDURE: Cryoimmunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults
Status: WITHDRAWN
Conditions: Pharmacokinetics
Interventions: DRUG: Acetaminophen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mesotherapy In Lateral Epicondylitis
Status: UNKNOWN
Conditions: Lateral Epicondylitis
Interventions: DRUG: Piroxicam, lidocaine|DEVICE: Mesotherapy without drug administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cuff Inflation-supplemented Videoscope-guided Nasal Intubation
Status: UNKNOWN
Conditions: Nasotracheal Intubation
Interventions: OTHER: Thermo-softening|OTHER: Room temperature
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Weight-Based Enoxaparin Dosing and Real-Time Dose Adjustment in Orthopaedic Trauma
Status: COMPLETED
Conditions: Venous Thromboembolism|Deep Vein Thrombosis|Pulmonary Embolus
Interventions: DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Early Versus Delayed Postoperative Feeding in Lower Limb Fracture Surgery
Status: NOT_YET_RECRUITING
Conditions: Lower Limb Fracture
Interventions: DIETARY_SUPPLEMENT: Early feeding/intervention group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Single-Use Duodenoscope in a Real-World Setting
Status: COMPLETED
Conditions: Endoscopic Retrograde Cholangiopancreatography (ERCP)
Interventions: DEVICE: aScope™ Duodeno endoscope and aBox™ Duodeno
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Study on Local Allergic Responses of Bee Venom and Essential Bee Venom Pharmacopuncture
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Bee Venom (BV)|DRUG: Essential Bee Venom (e-BV)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Body Weight Support Harness System in Spinal Muscular Atrophy
Status: COMPLETED
Conditions: Spinal Muscular Atrophy Type I|Spinal Muscular Atrophy Type II
Interventions: OTHER: In-home body weight support harness system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Drug Levels, Safety, and Tolerability of BMS-986036 in Participants With Normal Liver Function and Participants With Moderate and Severe Liver Impairment
Status: COMPLETED
Conditions: Moderate Liver Impairment|Severe Liver Impairment
Interventions: DRUG: BMS-986036
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Noninvasive Radiofrequency in Attenuating Diabetic Neuropathic Pain
Status: COMPLETED
Conditions: Diabetic Neuropathy, Painful
Interventions: DEVICE: Capacitive-Resistive Noninvasive Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Ulthera® System and Efficacy Correlation to Morphological Differences
Status: COMPLETED
Conditions: Facial and Neck Skin Laxity
Interventions: DEVICE: Microfocused ultrasound w/ visualization
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major Depression
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: ketamine|OTHER: IV Saline|PROCEDURE: ECT|DRUG: Muscle Relaxant|DRUG: Anesthetic Agents
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Influenza Vaccine Revaccination in Healthy Adults Previously Vaccinated With Fluzone ID or Fluzone IM
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza Virus Vaccine USP Trivalent Types A and B|BIOLOGICAL: Influenza Virus Vaccine USP Trivalent Types A and B|BIOLOGICAL: Influenza Virus Vaccine USP Trivalent Types A and B|BIOLOGICAL: Influenza Virus Vaccine USP Trivalent Types A and B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effect of Growth Hormone in Children With Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Disorder|Growth Hormone Deficiency in Children|Growth Disorder|Idiopathic Short Stature
Interventions: DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Manipulation and Rehabilitation to Rehabilitation Only, in the Management of Chronic Ankle Instability
Status: UNKNOWN
Conditions: Chronic Ankle Instability
Interventions: OTHER: Manipulative and Rehabilitative Therapy|OTHER: Rehabilitative Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacodynamic Effects of Sublingual Immunotherapy (Tablets) With Recombinant Bet v1
Status: COMPLETED
Conditions: Birch Pollen-Related Rhinoconjunctivitis|Rhinitis, Allergic, Seasonal
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: rBet v 1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pontic Site Development Using Soft Tissue Augmentation
Status: UNKNOWN
Conditions: Alveolar Bone Loss
Interventions: PROCEDURE: partially de-epithelized connective tissue graft|PROCEDURE: Mucograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing an Herbal Pain Relief Patch to Reduce Pain in Cancer Survivors
Status: ACTIVE_NOT_RECRUITING
Conditions: Cancer|Remission
Interventions: DRUG: Tibetree Pain Relieving Plaster|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Temozolomide in Recurrent Grade-4 Glioma Unmethylated MGMT Promoter (BORTEM-17)
Status: RECRUITING
Conditions: Glioblastoma
Interventions: DRUG: Bortezomib and Temozolomide Phase IB|DRUG: Bortezomib and Temozolomide Phase II
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immune Response In Children Revaccinated With Pneumococcal Conjugate Vaccine
Status: COMPLETED
Conditions: Invasive Pneumococcal Disease
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (13vPnC)|PROCEDURE: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: OTHER
Clinical trial: Controlled Study of Farabloc for Chronic Phantom Limb Pain Among Veteran Amputees
Status: COMPLETED
Conditions: Phantom Limb Pain
Interventions: DEVICE: Farabloc Limb Cover|DEVICE: Sham Limb Cover
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: User Performance Evaluation of Contour® Next One, Accu-Chek® Aviva Connect, FreeStyle Freedom Lite, OneTouch® Verio and GlucoMen® Areo Blood Glucose Monitoring Systems Following ISO 15197:2013
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DEVICE: Blood glucose monitoring system for self-testing Contour® Next One|DEVICE: Blood glucose monitoring system for self-testing Accu-Chek® Aviva Connect|DEVICE: Blood glucose monitoring system for self-testing FreeStyle Freedom Lite|DEVICE: Blood glucose monitoring system for self-testing OneTouch® Verio|DEVICE: Blood glucose monitoring system for self-testing GlucoMen® areo
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: QUALHYBOM Hypnosis Versus Equimolar Mixture of Oxygen and Nitrous Oxide (MEOPA) During a Bone Marrow Biopsy: a Clinical, Controlled, Randomized, Multicenter Study
Status: RECRUITING
Conditions: Bone Marrow Biopsy
Interventions: OTHER: Hypnosis|DRUG: Local anesthetic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: UVB Model Validation Study
Status: COMPLETED
Conditions: Pain|Inflammation|Healthy Volunteers
Interventions: DRUG: Ibuprofen, Hydrocortisone|DRUG: Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TIzanidine for the Preventive Treatment of Episodic MigrainE （TIME）
Status: RECRUITING
Conditions: Migraine Without Aura|Migraine With Aura
Interventions: DRUG: Tizanidine Hydrochloride|DRUG: Tizanidine Hydrochloride|DRUG: Tizanidine Hydrochloride Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Aroplatin and Gemcitabine in Patients With Advanced Pancreatic Cancer Resistant to Standard Therapies
Status: UNKNOWN
Conditions: Pancreatic Neoplasms
Interventions: DRUG: Aroplatin (Liposomal NDDP, L-NDDP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of CBT-1 and Paclitaxel With Carboplatin in Patients With Advanced Inoperable Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: CBT-1|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pubalgia and Adductor Tendinopathies Refractory to Medical Treatment
Status: UNKNOWN
Conditions: Groin Injury|Tendinopathy
Interventions: DRUG: Dysport 500 Unit Powder for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Assistance and Decision-making Algorithms in Hepatobiliary Tumor Boards
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma|Fibrolamellar Hepatocellular Carcinoma|Cholangiocarcinoma, Perihilar|Intrahepatic Cholangiocarcinoma|Metastasis to Liver|Gallbladder Carcinoma
Interventions: OTHER: ADBoard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Evaluation of Efficacy, Safety and Patient' Satisfaction of Therapeutic Switch From Off-Steroids to Budesonide
Status: COMPLETED
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: Budesonide Orodispersible Tablets (Jorveza)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Randomized Study of Intensive One-on-one Behavioral Treatment for Preschool Aged Children With Autism
Status: COMPLETED
Conditions: Autistic Disorder
Interventions: BEHAVIORAL: intensive one-on-one behavioral treatment|BEHAVIORAL: Individualized in home parent training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Modified Anti-Platelet Therapy Associated With Low-dose DES Firehawk in Acute Myocardial Infarction Patients Treated With Complete Revascularization Strategy
Status: ACTIVE_NOT_RECRUITING
Conditions: Myocardial Infarction, Acute|Coronary Artery Disease
Interventions: DRUG: Shortened DAPT followed by P2Y12 inhibitor monotherapy (cessation of aspirin)|DRUG: Standard DAPT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases
Status: COMPLETED
Conditions: Glaucoma|Macular Degeneration|Glaucoma Suspect|Optic Neuropathy|Retinal Degeneration|Visual Pathway Disorder
Interventions: DIAGNOSTIC_TEST: Visual Performance tests|DEVICE: Brain-computer interface
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extended-release Pharmacotherapy for Opioid Use Disorder
Status: COMPLETED
Conditions: Opiate Substitution Treatment
Interventions: DRUG: Buprenorphine Injectable Product|DRUG: Methadone|DRUG: Buprenorphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Laparoscopic Middle Hepatic Vein Guidance and Traditional Anatomic Hemihepatectomy
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: PROCEDURE: laparoscopic middle hepatic vein guidance anatomic hemihepatectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial About Hepatic Security of Antiretroviral Treatment Based on Kaletra Versus Nevirapine in Co-infected HIV/HCV Patients
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: Lopinavir/ritonavir|DRUG: Nevirapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Osteopathic Medicine in the Management of Care-induced Pain in Elderly Care (OGéDIS)
Status: TERMINATED
Conditions: Pain
Interventions: OTHER: Osteopathy|OTHER: Sham osteopathy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
Status: COMPLETED
Conditions: Headache|Pregnancy Related|Occipital Nerve Block
Interventions: DRUG: Occipital Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The 2-stage Approach for Reducing Posterior Wall Puncture During the Internal Jugular Vein Catheterization
Status: COMPLETED
Conditions: Hematoma
Interventions: PROCEDURE: Central venous catheterization|PROCEDURE: Central venous catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Investigating the Anti-epileptic Efficacy of Afinitor (Everolimus) in Patients With Refractory Seizures Who Have Focal Cortical Dysplasia Type II (FCD II)
Status: COMPLETED
Conditions: Epilepsy and Focal Cortical Dysplasia II
Interventions: DRUG: Afinitor (everolimus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Cohort of Emergent Laparoscopic Cholecystectomy in PUMCH
Status: COMPLETED
Conditions: Acute Cholecystitis
Interventions: PROCEDURE: Emergent laparoscopic cholecystectomy guided by ICG cholangiography (ELC-ICGC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Benefit of the Chalaxie Pedagogical Tool in the Management of Overweight or Obese Children With Intellectual Disability : a Pilot Monocentric Prospective Study.
Status: COMPLETED
Conditions: Pediatric Obesity
Interventions: PROCEDURE: Use of the Chalaxie pedagogical evaluation tool
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sorafenib in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery
Status: COMPLETED
Conditions: Stage III Melanoma|Stage IV Melanoma
Interventions: DRUG: sorafenib tosylate|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HILOTERM® Device for the Prevention of Peripheral Neuropathy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Neuropathy;Peripheral
Interventions: DEVICE: Hilotherm® Cooling treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Olanzapine vs. Comparator and Placebo in the Treatment of Patients With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: olanzapine|DRUG: divalproex sodium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Deleterious BARD1 Gene Mutation|Deleterious BRCA1 Gene Mutation|Deleterious BRCA2 Gene Mutation|Deleterious BRIP1 Gene Mutation|Deleterious EPCAM Gene Mutation|Deleterious MLH1 Gene Mutation|Deleterious MSH2 Gene Mutation|Deleterious MSH6 Gene Mutation|Deleterious PALB2 Gene Mutation|Deleterious PMS2 Gene Mutation|Deleterious RAD51C Gene Mutation|Deleterious RAD51D Gene Mutation|Hereditary Breast and Ovarian Cancer Syndrome|Premenopausal
Interventions: OTHER: Laboratory Biomarker Analysis|PROCEDURE: Oophorectomy|OTHER: Quality-of-Life Assessment|PROCEDURE: Salpingectomy|PROCEDURE: Salpingo-Oophorectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combination Sunitinib and Gemcitabine in Sarcomatoid and/or Poor-risk Patients With Metastatic Renal Cell Carcinoma
Status: COMPLETED
Conditions: Renal Cell Carcinoma|Neoplasm Metastases
Interventions: DRUG: Gemcitabine|DRUG: Sunitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy of Primary Breast Cancer With Epirubicin/Docetaxel and Carboplatin/Docetaxel
Status: COMPLETED
Conditions: Primary Breast Cancer
Interventions: DRUG: Epirubicin, Carboplatin, Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Immunotherapy and Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trial
Status: RECRUITING
Conditions: Gastric Cancer|Stomach Neoplasm
Interventions: DRUG: XELOX or SOX|DRUG: JS001+XELOX or SOX
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DIetary REstriction as an Adjunct to Neoadjuvant ChemoTherapy for HER2 Negative Breast Cancer
Status: COMPLETED
Conditions: Fasting Mimicking Diet|Breast Cancer|Neoadjuvant Chemotherapy|Pathological Complete Response
Interventions: OTHER: Fasting mimicking diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living With HIV
Status: ACTIVE_NOT_RECRUITING
Conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma|HIV-1-infection|HPV Infection
Interventions: BIOLOGICAL: 9 valent human papillomavirus vaccine (Types 6, 11, 16, 18, 31, 33, 45, 52, 58)|OTHER: Saline Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Conservative Treatment Versus the Surgical Treatment of Diaphyseal Fractures of Humerus
Status: TERMINATED
Conditions: Humeral Diaphysis Fracture
Interventions: PROCEDURE: Plate and screws or nailing|DEVICE: Hanging Support System (HSS) brace
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking
Status: RECRUITING
Conditions: Lung Carcinoma|Tobacco-Related Carcinoma
Interventions: OTHER: Survey Administration|OTHER: Educational Activity|OTHER: Survey Administration|OTHER: Electronic Health Record Review|OTHER: Educational Activity|OTHER: Counseling|OTHER: Survey Administration|OTHER: Electronic Health Record Review
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Comparison of the Efficacy of Different Nerve Stimulation Methods in Individuals With Chronic Consipation
Status: COMPLETED
Conditions: Constipation
Interventions: OTHER: Auricular vagus stimulation|OTHER: Tibial Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety and Performance Evaluation of ReWalk Reciprocating Gait Orthosis (RGO)
Status: COMPLETED
Conditions: Paraplegia|Spinal Cord Injuries (SCI)
Interventions: DEVICE: ReWalk - a motorized exoskeleton suit
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Busulfan Plus Clofarabine Followed by Allogeneic Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Leukemia|Lymphoma|Allogeneic Haematopoietic Stem Cell Transplantation|Acute Lymphoblastic Leukemia
Interventions: DRUG: Busulfan|DRUG: Clofarabine|DRUG: Thymoglobulin|PROCEDURE: Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brentuximab Vedotin With or Without Nivolumab in Treating Patients With Relapsed or Refractory CD30+ Lymphoma
Status: RECRUITING
Conditions: Recurrent Hodgkin Lymphoma|Recurrent Non-Hodgkin Lymphoma|Refractory Hodgkin Lymphoma|Refractory Non-Hodgkin Lymphoma
Interventions: DRUG: Brentuximab Vedotin|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GENESIS Feasibility Study of the BARD Over-the-Wire Mesh Ablation System for the Treatment of Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: PROCEDURE: Catheter Ablation of Paroxysmal Atrial Fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dabigatran as an Alternative Anticoagulant in Patients With Left Ventricular Assist Device (LVAD)
Status: TERMINATED
Conditions: Thrombosis|Bleeding
Interventions: DRUG: Dabigatran|DRUG: Phenprocoumon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Radiotherapy Induced Enteropathy by Probiotics (PREP)
Status: UNKNOWN
Conditions: Radiotherapy|Toxicity|Diarrhea|Probiotics
Interventions: DRUG: Bacillus Licheniformis|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Low Intensity Shockwave Therapy for ED in Post Radical Prostatectomy Patients Who Didn't Respond to PDE5i
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DEVICE: LI-ESWT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lymphatic Filariasis (LF) in Ivory Coast
Status: COMPLETED
Conditions: Lymphatic Filariasis
Interventions: DRUG: Albendazole|DRUG: Ivermectin|DRUG: Diethylcarbamazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148
Status: TERMINATED
Conditions: Septic Shock
Interventions: DRUG: LB1148|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Craniosacral Treatment on Child Neurodevelopment
Status: COMPLETED
Conditions: Child Development Disorder
Interventions: DIAGNOSTIC_TEST: Online questionnaire of children's backgrounds|OTHER: Academic behavioral intervention of teachers|PROCEDURE: Therapy sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT