pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Safety, Efficacy and Pharmacokinetic Study of AGN-199201 and AGN-190584 in Patients With Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DRUG: AGN-199201 ophthalmic solution|DRUG: AGN-190584 ophthalmic solution|DRUG: AGN-199201 Vehicle|DRUG: AGN-190584 Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Volar Locking Plate Fixation Alone and Volar Locking Plate Fixation Plus Calcium Phosphate Bone Cement Augmentation for Distal Radius Fractures Patients Aged More Than 65
Status: COMPLETED
Conditions: Distal Radius Fracture
Interventions: PROCEDURE: calcium phosphate bone cement injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Hemodynamic Effects, Safety, Tolerability, and Pharmacokinetics of Intravenous APD418 in Adult Participants With Heart Failure With Reduced Ejection Fraction
Status: TERMINATED
Conditions: Acute Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: APD418|DRUG: APD418|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Restricted vs. Free Knee Range Of Motion For Primary Traumatic Patellar Dislocation
Status: UNKNOWN
Conditions: Patellar Dislocation
Interventions: PROCEDURE: Locked knee brace|PROCEDURE: Locked knee brace
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism
Status: COMPLETED
Conditions: Pulmonary Embolism|Thrombotic Disease
Interventions: DRUG: DS-1040b|DRUG: Placebo|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Relational and Emotional Mechanisms of a Supportive-expressive Group Intervention in Breast Cancer
Status: UNKNOWN
Conditions: Breast Neoplasms|Breast Cancer
Interventions: OTHER: Supportive-expressive group therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Electronic Messaging to Increase Human Papillomavirus Vaccine Utilization and Adherence Among College Students
Status: COMPLETED
Conditions: Patient Compliance|Health Knowledge, Attitudes, Practice
Interventions: PROCEDURE: Electronic Message
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Phase III Study of the Correlation Between Florbetapir F18 PET Imaging and Amyloid Pathology in the Brain
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: florbetapir F 18
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Hydroxychloroquine Chemoprophylaxis for COVID-19 Infection in High-risk Healthcare Workers.
Status: UNKNOWN
Conditions: SARS-CoV-2|Healthcare Workers
Interventions: DRUG: Hydroxychloroquine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Bafiertam 190 mg and Vumerity® 462 mg Delayed-Release Capsules in Fasting Healthy Subjects
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Monomethyl Fumarate 190 Mg|DRUG: Diroximel Fumarate 462 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Conventional Instrumentation, Computer Navigation, and Robotic Assistance Techniques in TKA
Status: WITHDRAWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: ROSA Knee System|DEVICE: KneeAlign Computer Assisted Navigation System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rocuronium vs Cis-atracurium: Do Rocuronium Still 'ROCKS' In Coronary Artery Bypass Grafting
Status: COMPLETED
Conditions: Neuromuscular Blockade|Postoperative Pulmonary Atelectasis|Postoperative Pulmonary Complication|Coronary Artery Disease|Coronary Artery Bypass Grafting|Hypothermic Cardiopulmonary Bypass
Interventions: DRUG: Rocuronium Bromide 10 MG/ML|DRUG: Nimbex 10 MG in 5 ML Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Propranolol Hydrochloride 1 MG/ML|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: T1Rho MRI Evaluation of Patellofemoral Changes After Tibial IM Nailing
Status: COMPLETED
Conditions: Acute Tibial Fracture Requiring Intramedullary Nailing
Interventions: PROCEDURE: Intramedullary nailing of the tibia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarker for Hyaline Fibromatosis Syndrome (BioHFS)
Status: WITHDRAWN
Conditions: Hyalinosis|Hyaline Membrane Disease|Juvenile Hyaline Fibromatosis|Fibromatosis Hyalinica Multiplex Juvenilis|Skin and Connective Tissue Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Trial Comparing Adjuvant Oral UFT/LV to 5-FU/l-LV in Stage III Colorectal Cancer (JCOG-0205-MF)
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: 5FU+l-leucovorin|DRUG: UFT+Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationships Between Quality of Ageing and Age-related Degenerated Disease (Compalimage)
Status: UNKNOWN
Conditions: Age-related Degenerated Disease
Interventions: OTHER: Measurement of muscle protein synthesis using stable isotopes and muscle biopsies.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: COVID-19 Aerosol in EGD Using a Droplet Reduction Mouthpiece
Status: COMPLETED
Conditions: Droplet Spread|Covid19
Interventions: DEVICE: Mouthpiece B1(Mouthpiece MPC-ST GMDN:62534 Generic name: Endoscopic bite block, basic, reusable
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Aimed at Evaluation of the Effectiveness and Tolerability of an Anti-cellulite Cream Medical Device
Status: RECRUITING
Conditions: Cellulite
Interventions: DEVICE: Anti-cellulite cream-gel Medical Device (DEFBODY)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selinexor (KPT-330) Plus FLAG-Ida for the Treatment of Relapsing/Refractory AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Selinexor|DRUG: fludarabine|DRUG: idarubicin|DRUG: cytarabine|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Oxygen Devices in Hypoxemic COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease Severe
Interventions: DEVICE: Companion (Liquid oxygen device)|DEVICE: Activox (concentrator)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Acute Lymphoblastic Leukemia|Chronic Myelogenous Leukemia|High-risk Myelodysplastic Syndrome|Chronic Lymphocytic Leukemia|Advanced Myelofibrosis
Interventions: DRUG: TH-302
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: M7824 in Combination With Chemotherapy in Stage IV Non-small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Pemetrexed|DRUG: Nab-paclitaxel|DRUG: Gemcitabine|DRUG: Docetaxel|DRUG: M7824|DRUG: Carboplatin|DRUG: Carboplatin|DRUG: Bintrafusp alfa|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Mindfulness Meditation Based on Brain Computer Interface in Radiofrequency Ablation
Status: COMPLETED
Conditions: Atrial Fibrillation|Radiofrequency Ablation|Meditation|Pain|Fatigue|Anxiety|Depression|Brain-Computer Interfaces
Interventions: COMBINATION_PRODUCT: Mindfulness meditation based on brain-computer interface|COMBINATION_PRODUCT: Routine care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Tomosynthesis Versus Digital Mammography in a Population-based Screening Program
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: OTHER: Invitation for breast screening and random allocation|DEVICE: DBT|DEVICE: Conventional digital mammography.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SCREENING
Clinical trial: Supervised Exercise for Post-surgery Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Neoplasms
Interventions: BEHAVIORAL: Aerobic and resistance training 12 week exercise programme|DIAGNOSTIC_TEST: Venous blood sampling|DIAGNOSTIC_TEST: Muscle Ultrasound|DIAGNOSTIC_TEST: Cardiopulmonary exercise testing (CPET)|BEHAVIORAL: Quality of life questionnaire completion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Utility of Treatment With Nasogastric Tube Placement for Small Bowel Obstruction
Status: RECRUITING
Conditions: Small Bowel Obstruction|Frailty|Nasogastric Tube
Interventions: PROCEDURE: Nasogastric tube placement|DIAGNOSTIC_TEST: Clinical Frailty Scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Evaluating the Effect of Jublia on Dermatophytomas
Status: COMPLETED
Conditions: Onychomycosis|Dermatophytosis
Interventions: DRUG: Jublia (Efinaconazole 10% Topical Solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbohydrate Loading Fasting Protocol Versus 'Sip Til Send'
Status: ACTIVE_NOT_RECRUITING
Conditions: Study Different Fasting Protocols in Patients for Elective Cesarean Deliveries
Interventions: DIETARY_SUPPLEMENT: Pre op Carbohydrate drink|OTHER: Clear fluid as per sip til send policy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Investigation Of The Absorption And Pharmacokinetics Of A Single Dose Of A Controlled Release (CR) Pregabalin Tablet Following Various Sized Lunches As Compared To A Single Dose Of The Immediate Release (IR) Pregabalin Capsule In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Pregabalin controlled release, 330 mg, 400 to 500 calories|DRUG: Pregabalin controlled release, 330 mg, 600 to 750 calories|DRUG: Pregabalin controlled release, 330 mg, 800 to 1000 calories|DRUG: Pregabalin immediate release, 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Trials of Five Different Food Supplements With Restriction Diet in Adults
Status: COMPLETED
Conditions: Overweight and Obesity|Inflammation|Hypercholesterolemia|Hypertension
Interventions: DIETARY_SUPPLEMENT: IP1|DIETARY_SUPPLEMENT: IP2|DIETARY_SUPPLEMENT: IP3|DIETARY_SUPPLEMENT: IP4|DIETARY_SUPPLEMENT: IP5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: The Iron and Muscle Study
Status: COMPLETED
Conditions: CKD Stage 3|CKD Stage 4|Iron-deficiency
Interventions: DRUG: Ferinject|OTHER: Placebo: NaCl (sodium chloride 0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Placebo-Controlled Single-Dose Trial of Sildenafil in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Sildenafil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II, Comparative Study of Seroconversion of Single-Dose and Two-Dose Measles Vaccination in HIV-Infected and HIV-Uninfected Children: A Multicenter Trial of the Pediatric AIDS Clinical Trials Group
Status: COMPLETED
Conditions: HIV Infections|Measles
Interventions: BIOLOGICAL: Attenuvax|BIOLOGICAL: M-M-R-II
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Ledipasvir/Sofosbuvir in Hepatitis C Virus-Infected Children With Hematological Malignancy
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hematologic Malignancy
Interventions: DRUG: Ledipasvir / Sofosbuvir Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus
Status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: HDM1002 50 mg|DRUG: HDM1002 100 mg|DRUG: HDM1002 200 mg|DRUG: HDM1002 400 mg|DRUG: HDM1002 200 mg BID|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotics and the Gut Microbiome in Obese Hispanic Youth
Status: TERMINATED
Conditions: Obesity, Abdominal|Adiposity
Interventions: DIETARY_SUPPLEMENT: VSL#3|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Study on an Investigational Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Administered as a 5- and/or 10-year Booster Doses in Children and Adolescents Vaccinated 5 or 10 Years Earlier as Toddlers
Status: ACTIVE_NOT_RECRUITING
Conditions: Meningococcal Immunisation|Healthy Volunteers
Interventions: BIOLOGICAL: Meningococcal Polysaccharide (Serogroups A, C, W, and Y) Tetanus Toxoid Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mobility Protocol Adapted for Advanced Visually Impaired Subjects
Status: UNKNOWN
Conditions: Pigmentary Retinopathy
Interventions: BEHAVIORAL: Locomotion task|BEHAVIORAL: Posturology task SOT (Sensory Organization Test)|BEHAVIORAL: The quality of life questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study to Assess the Safety and Tolerability of ANG-3070 in Subjects With Idiopathic Pulmonary Fibrosis
Status: UNKNOWN
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Interventions: DRUG: ANG-3070|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Effects of Vitamin D Repletion in Patients With Parkinson's Disease
Status: TERMINATED
Conditions: Parkinson's Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D3|DIETARY_SUPPLEMENT: Vitamin D3 - high dose|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Combination of Camrelizumab and Apatinib as Second-line Therapy for Advanced Pancreatic Carcinoma
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: DRUG: Camrelizumab|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Magnetic Brain Stimulation in Treatment of Obsessive Compulsive Disorder
Status: SUSPENDED
Conditions: Obsessive Compulsive Disorder
Interventions: DEVICE: Transcranial Magnetic Stimulation|DEVICE: Sham Transcranial Magnetic Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Trial of Modified FOLFOX 6 and Cetuximab in First Line Treatment of Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: Cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)
Status: NOT_YET_RECRUITING
Conditions: Hypotension After Cardiac Surgery
Interventions: DRUG: Angiotensin II
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Mitoxantrone Hydrochloride Liposome Infusion
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Mitoxantrone Hydrochloride Liposome
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Continuous Positive Airway Pressure for Treatment of Obstructive Sleep Apnea on Resistant Hypertension
Status: COMPLETED
Conditions: Resistant Hypertension|Obstructive Sleep Apnea
Interventions: DEVICE: continuous positive airway pressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Safety and Efficacy of a Novel SeaLA™ Left Atrial Appendage Occluder
Status: ACTIVE_NOT_RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: SeaLA™ left atrial appendage occluder
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effectiveness of Fibrous Foods, Sugar-free Gomes and Rolly Brush® in the Dental Biofilm Removal
Status: COMPLETED
Conditions: Self Cleaning
Interventions: DEVICE: Comparison of dental biofilm removal.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Safety and Efficacy Study of VIS649 for IgA Nephropathy
Status: COMPLETED
Conditions: Immunoglobulin A Nephropathy|Glomerular Disease|IgAN
Interventions: DRUG: Dose-Placebo|DRUG: Low Dose-VIS649|DRUG: Medium Dose-VIS649|DRUG: High Dose-VIS649
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Dose Study of DWP10292 and UDCA in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DWP10292|DRUG: DWP10292 Placebo|DRUG: Ursodeoxycholic acid (UDCA)|DRUG: UDCA Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy, Safety and Cost-efficacy of a Pre-emptive Genotyping Strategy in Patients Receiving Statins
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Dyslipidemias|Statin Adverse Reaction|Pharmacogenic Myopathy
Interventions: OTHER: Preemptive pharmacogenetic atorvastatin dose based on CPIC guidelines|OTHER: Preemptive pharmacogenetic simvastatin dose based on CPIC guidelines|OTHER: Preemptive pharmacogenetic pitavastatin dose based on CPIC guidelines|OTHER: Preemptive pharmacogenetic rosuvastatin dose based on CPIC guidelines|OTHER: Preemptive pharmacogenetic pravastatin dose based on CPIC guidelines|OTHER: Preemptive pharmacogenetic lovastatin dose based on CPIC guidelines|OTHER: Preemptive pharmacogenetic fluvastatin dose based on CPIC guidelines|OTHER: Standard of Care (SoC) dosing of atorvastatin|OTHER: Standard of Care (SoC) dosing of simvastatin|OTHER: Standard of Care (SoC) dosing of pitavastatin|OTHER: Standard of Care (SoC) dosing of rosuvastatin|OTHER: Standard of Care (SoC) dosing of prasavastatin|OTHER: Standard of Care (SoC) dosing of lovastatin|OTHER: Standard of Care (SoC) dosing of fluvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Management of Drug-resistant Epilepsy in Infants and Children: a Real-life Study of the Use of the Ketogenic Diet in France and the KetoCal® Range in Its Maintenance
Status: RECRUITING
Conditions: Drug Resistant Epilepsy|Ketogenic Dieting
Interventions: OTHER: Ketocal
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke
Status: SUSPENDED
Conditions: Ischemic Stroke
Interventions: DRUG: Pinocembrin for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patients' Preference for Subcutaneous or Vaginal Progesterone as Luteal Support in IVF/ICSI Cycles
Status: TERMINATED
Conditions: Infertility|In Vitro Fertilization
Interventions: DRUG: Progesterone 25 MG subcutaneous|DRUG: Micronized progesterone 200 MG|DRUG: recombinant FSH|DRUG: Cetrorelix Acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Relationship Between Exercise Frequency, Intensity, and Restoration of Cardiometabolic Health
Status: COMPLETED
Conditions: Overweight or Obesity
Interventions: BEHAVIORAL: Endurance Exercise Training (END)|BEHAVIORAL: Sprint Exercise Training (SIT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: ID-Cap System Under Direct Observation
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DEVICE: ID-Capsule- Active|DEVICE: Wearable Sensor|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: The Effects of Different Exercise Approaches in Patients With Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: Yoga exercise program|OTHER: Spinal stabilization exercise program|OTHER: Aerobic walking program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment Success and Failure in HIV-Infected Subjects Receiving Indinavir in Combination With Nucleoside Analogs: A Rollover Study for ACTG 320
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Indinavir sulfate|DRUG: Abacavir sulfate|DRUG: Nelfinavir mesylate|DRUG: Efavirenz|DRUG: Levocarnitine|DRUG: Adefovir dipivoxil|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Plaque Control Efficacy Between Interdental Brushes Versus Dental Floss
Status: COMPLETED
Conditions: Periodontal Diseases|Dental Plaque
Interventions: DEVICE: Dental floss/Interdental brush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Arsenic Trioxide in Treating Patients With Recurrent or Refractory Acute Leukemia, Chronic Myeloide Leukemia, Myelodysplasia, Lymphoma, or Myeloma
Status: UNKNOWN
Conditions: Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes
Interventions: DRUG: arsenic trioxide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cabazitaxel vs Abiraterone or Enzalutamide in Patients With Poor Prognosis Metastatic Castration-resistant Prostate Cancer
Status: UNKNOWN
Conditions: Metastatic Castration-Resistant Prostatic Cancer
Interventions: DRUG: cabazitaxel|DRUG: Abiraterone|DRUG: Enzalutamide 160mg daily (oral)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PU-H71 With Nab-paclitaxel (Abraxane) in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: PU-H71|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Proton Pump Inhibitors (PPI) to Prevent Strictures After Gastric Bypass Surgery
Status: WITHDRAWN
Conditions: Anastomotic Stricture|Morbid Obesity
Interventions: DRUG: Esomeprazole|DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treatment Efficacy of Local Anesthetic/Steroid Mixture Injection for Patients With Odynophonia
Status: WITHDRAWN
Conditions: Patients With a Diagnosis of Odynophonia
Interventions: DRUG: Bupivacain|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Sacubitril/Valsartan in Maintenance Hemodialysis Patients With Heart Failure
Status: UNKNOWN
Conditions: Hemodialysis Complication|Heart Failure
Interventions: DRUG: Sacubitril / Valsartan Oral Tablet [Entresto]|DRUG: Valsartan 80mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ALT-801 in Diabetic and Non-Diabetic Overweight and Obese Subjects With Non-alcoholic Fatty Liver Disease (NAFLD)
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: ALT-801|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RECOVAC - Long Term Efficacy and Safety of COVID-19 (SARS-CoV-2) Vaccination in Kidney Disease Patients
Status: COMPLETED
Conditions: Covid19|SARS-CoV Infection|Chronic Kidney Diseases
Interventions: DIAGNOSTIC_TEST: mailer-based finger-prick
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Study of Preoperative Gemcitabine Plus CP-870, 893 Followed by Addition of CP-870,893 to Standard -Of-care Adjuvant Chemoradiation for Patients With Newly Diagnosed Resectable Pancreatic Carcinoma
Status: COMPLETED
Conditions: Adenocarcinoma Pancreas
Interventions: OTHER: Gemcitabine|DRUG: CP-870,893
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: 131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiation in Patients With Multiple Brain Metastases From Solid Tumors
Status: COMPLETED
Conditions: Brain Metastases From Solid Tumors
Interventions: RADIATION: 131I-L19SIP Radioimmunotherapy (RIT) in Combination With Whole Brain Radiation Therapy (WBRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detection Of β-thalassemia Carriers In Assiut
Status: UNKNOWN
Conditions: Beta-Thalassemia
Interventions: DIAGNOSTIC_TEST: CBC, Iron Study, Serum Ferrittin, HPLC,Genitic Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pediatric Reporting of Adult-Onset Genomic Results
Status: ACTIVE_NOT_RECRUITING
Conditions: Hereditary Breast and Ovarian Cancer Syndrome|Lynch Syndrome|Familial Hypercholesterolemia
Interventions: GENETIC: Receive an adult-onset result|GENETIC: Receive a pediatric-onset result|GENETIC: Control - No Result
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Hypersensitivity to Phosphodiesterase 5 Inhibition in Post-Traumatic Headache
Status: RECRUITING
Conditions: Post-Traumatic Headache
Interventions: DRUG: Sildenafil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: Salmonella typhi vaccine (Typhim Vi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Spina Bifida|Musculoskeletal Disorder|Juvenile Arthritis|Amputation|Cerebral Palsy
Interventions: OTHER: Pathways and Resources to Engagement and Participation (PREP)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
Status: RECRUITING
Conditions: Propofol|Glioma|Auditory Event-related Potential (AERP)|Electroencephalogram (EEG)|Brain Network Connectivity
Interventions: DRUG: Propofol Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lifestyle Intervention in Pregnant Women With PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Overweight and Obesity|Gestational Diabetes
Interventions: BEHAVIORAL: Intensive Lifestyle Intervention|BEHAVIORAL: Standard Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Focal Segmental Glomerulosclerosis
Interventions: DRUG: sparsentan|DRUG: Irbesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, PK/PD and Preliminary Efficacy of HBM4003 Combined With Anti-PD-1 Antibody
Status: UNKNOWN
Conditions: Solid Tumor
Interventions: DRUG: HBM4003 and pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions
Status: UNKNOWN
Conditions: Depression|Depressive Disorder|Behavioral Symptoms|Mood Disorders|Mental Disorders
Interventions: BEHAVIORAL: Growth Mindset Online Single-Session Program|BEHAVIORAL: Self-Kindness Online Single-Session Program|BEHAVIORAL: Supportive Therapy Online Single-Session Program (Control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The "PC-LIGHT" Study
Status: COMPLETED
Conditions: Prostate Cancer|Sleep|Depression|Fatigue|Quality of Life
Interventions: DEVICE: Intervention systematic light exposure|DEVICE: Comparison systematic light exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Primary Paclitaxel Plus Gemcitabine in Patients With Stage II and III Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Paclitaxel/Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective, Single-Arm, Study to Assess the Safety and Performance of the TB1-K Device for Organ Preservation in Donor Kidneys for Transplantation
Status: UNKNOWN
Conditions: Kidney Preservation and Transportation
Interventions: DEVICE: TB1-K
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Imaging of Peri-operative (periOP) Lung Injury
Status: TERMINATED
Conditions: Acute Lung Injury|Chronic Obstructive Pulmonary Disease (COPD)
Interventions: RADIATION: SPECT-CT imaging|DRUG: AxV-128/Tc|PROCEDURE: Whipple procedure|PROCEDURE: Major surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera
Status: RECRUITING
Conditions: Typhoid and/or Cholera Vaccination
Interventions: DRUG: Vivotif Typhoid Oral Vaccine|DRUG: Vaxchora
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Spondylolisthesis|Retrolisthesis
Interventions: DEVICE: FLXfit™ TLIF Interbody Fusion Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Behavioral Intervention for Children With Attention Deficit Hyperactivity Disorder(ADHD)
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: A randomized controlled study of Executive Function training for children with ADHD
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of Keyhole Gallbladder Surgery With Removal of Gallbladder Via the Stomach Rather Than Through the Skin
Status: WITHDRAWN
Conditions: Gallstones
Interventions: PROCEDURE: Recovery of gallbladder via gastrotomy instead of via the skin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Magrolimab Combination Therapy in Patients With Non-Surgically Removable Locally Advanced or Metastatic Triple-Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Triple-Negative Breast Cancer
Interventions: DRUG: Magrolimab|DRUG: Nab-Paclitaxel|DRUG: Paclitaxel|DRUG: Sacituzumab Govitecan-hziy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apremilast - Oral Lichen Planus Trial
Status: WITHDRAWN
Conditions: Oral Lichen Planus
Interventions: DRUG: Apremilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab for Central Retinal Vein Occlusion Study
Status: COMPLETED
Conditions: Central Retinal Vein Occlusion
Interventions: DRUG: bevacizumab|DRUG: Sham bevacizumab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Medial Epicondyle Fractures in Children and Adolescents
Status: RECRUITING
Conditions: Medial Epicondyle Fracture of the Humerus|7 to16 Year Old Children and Adolecents|More Than 2 mm of Displacement
Interventions: PROCEDURE: Operative treatment|PROCEDURE: Long arm cast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Equine-assisted Therapy Effectiveness in Improving Emotion Regulation of Patients Suffering From Substance Use Disorder
Status: RECRUITING
Conditions: Substance Use Disorder (SUD)
Interventions: BEHAVIORAL: Equine-assisted Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST)
Status: COMPLETED
Conditions: Schistosomiasis
Interventions: DRUG: 4x Praziquantel|DRUG: 1x Praziquantel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
Status: RECRUITING
Conditions: Chronic Kidney Diseases
Interventions: DRUG: Finerenone|DRUG: Placebo Finerenone|DRUG: Endothelin Receptor Antagonist|DRUG: Placebo Endothelin Receptor Antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Immunogenicity of Different Clinical Trial Materials of Ad26.RSV.preF- Based Vaccine in Adults Aged 60 - 75 Years Old
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Prevention
Interventions: BIOLOGICAL: Ad26.RSV.preF-based vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Retinal Imaging Study of Children That Might be at Risk of Having Retinal Hemorrhages
Status: RECRUITING
Conditions: Retinal Hemorrhage, Bilateral|Retinal Hemorrhage, Left Eye|Retinal Hemorrhage, Right Eye
Interventions: DIAGNOSTIC_TEST: ophthalmoscopy and fundus photography through dilated pupills
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mindfulness-based Cognitive Therapy for Patients With Functional Disorders
Status: COMPLETED
Conditions: Somatization Disorder|Functional Disorders|Bodily Distress Disorder
Interventions: BEHAVIORAL: Mindfulness-Based Cognitive Therapy for Functional Disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
Status: COMPLETED
Conditions: Vitreous Hemorrhage|Proliferative Diabetic Retinopathy
Interventions: DRUG: intravitreal injection of bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Anaesthesia-depth Trough Narcotrend TM in Patients Undergoing Electro-Convulsion-Therapy (ECT)- Influence of Anasthesia Depth on Quality of Convulsion
Status: COMPLETED
Conditions: Anesthesia
Interventions: DEVICE: Narcotrend TM
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 3D Shoulder Kinematics During Throwing-related Movement Patterns Tasks in Upper Extremity Low-to-moderate/Moderate-to-high Loading Conditions
Status: UNKNOWN
Conditions: Shoulder Pain
Interventions: BEHAVIORAL: PNF D2 for flexion; low-to-moderate loading condition|BEHAVIORAL: PNF D2 for flexion; moderate-to-high loading condition|BEHAVIORAL: PNF D2 for extension; low-to-moderate loading condition|BEHAVIORAL: PNF D2 for extension; moderate-to-high loading condition
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase I Clinical Trial of COVID-19 mRNA Vaccine in Adults Aged 18 Years and Older
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: COVID-19 mRNA vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Curodont Repair on Color Change of White Spot Lesions
Status: UNKNOWN
Conditions: White Spot Lesion
Interventions: DRUG: Curodont Repair|DRUG: fluoride varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency
Status: COMPLETED
Conditions: Trophic Ulcers|Chronic Venous Insufficiency
Interventions: DEVICE: LASMIK|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001
Status: COMPLETED
Conditions: Osteoarthritis|Pain
Interventions: DRUG: Placebo|DRUG: Fulranumab 1 mg|DRUG: Fulranumab 3 mg|DRUG: Opioid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Confocal Reflectance Microscopy of Shave-Biopsy Sites on Skin in Vivo.
Status: COMPLETED
Conditions: Basal Cell Carcinoma|Melanoma|Squamous Cell Carcinoma|Non-Malignant Skin Disorders
Interventions: PROCEDURE: confocal microscopy in vivo
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Wavelet Index in Monitoring the Sedation Depth of Remimazolam Besylate
Status: NOT_YET_RECRUITING
Conditions: Remimazolam|Anesthesia Awareness|Sedative, Hypnotic, or Anxiolytic Withdrawal
Interventions: DRUG: Remimazolam besylate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Family Participation in CICU Rounds: RCT
Status: UNKNOWN
Conditions: Family Members|Health Care Providers|Engagement, Patient
Interventions: OTHER: Direct participation of the family member in the daily rounds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: FFR Versus IVUS With Angiography-Derived FFR for Clinical Outcomes in Patients With Coronary Artery Disease
Status: NOT_YET_RECRUITING
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Intravascular ultrasound-guided stent implantation after angiography-derived FFR-based decision-making|PROCEDURE: Fractional flow reserve-guided PCI strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anastomotic Techniques in Pancreaticoduodenectomy
Status: UNKNOWN
Conditions: Pancreatic Cancer|Pancreatic Fistula
Interventions: PROCEDURE: type of anastomosis after pancreaticoduodenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Over-the-counter NSAIDS on Cough Reflex Sensitivity in Patients With Upper Respiratory Tract Infections
Status: RECRUITING
Conditions: Cough|Upper Respiratory Tract Infections
Interventions: DRUG: Flurbiprofen Oral Lozenge|DRUG: Difflam|DRUG: Flurbiprofen 8.75 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Preoperative Exercise on the Prevention of Secondary Lymphedema in Breast Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Breast Neoplasms
Interventions: BEHAVIORAL: Aerobic exercise, Strength training, Flexibility exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Tolerability of Liraglutide in Healthy Volunteers and Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2|Healthy
Interventions: DRUG: liraglutide|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted vs Standard Fortification of Breast Milk
Status: RECRUITING
Conditions: BPD - Bronchopulmonary Dysplasia|NEC - Necrotizing Enterocolitis|Weight Gain|VLBW - Very Low Birth Weight Infant|ROP - Retinopathy of Prematurity
Interventions: DIETARY_SUPPLEMENT: Tailored enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Psychoeducational Intervention for People With Suicidal Behaviour in the Penitentiary Environment. N'VIU Project
Status: COMPLETED
Conditions: Suicide
Interventions: OTHER: Psychoeducational intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT