pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Pilot Safety Study to Determine the Ability of the Protector Cap Jet Injector to Prevent Cross-Contamination
Status: COMPLETED
Conditions: Virus Diseases|Hepatitis B
Interventions: DEVICE: Jet Injector with Protector Cap (HSI-500)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Intake Effect of EPs® 7630 (an Extract of the Roots of Pelargonium Sidoides)
Status: COMPLETED
Conditions: Common Cold
Interventions: DRUG: EPs® 7630|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: NeurostImulation for Cognitive Enhancement in Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease|Dementia
Interventions: DEVICE: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver active tDCS.|DEVICE: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver sham tDCS.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks
Status: COMPLETED
Conditions: Metabolic Syndrome|Insulin Resistance|Dyslipidemia
Interventions: OTHER: Glucose|OTHER: Fructose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of Muscle Energy Technique Alone and in Combination With Interferential Therapy for the Treatment of Non-specific Low Back Pain.
Status: COMPLETED
Conditions: Back Pain
Interventions: OTHER: muscle energy technique|OTHER: Muscel energy technique along with interferential therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disorder
Status: TERMINATED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Rapastinel|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Flow Monitoring to Prevent Post-Polypectomy Induced Ulcer Bleeding
Status: RECRUITING
Conditions: Delayed Post-Polypectomy Induced Ulcer Hemorrhage
Interventions: DEVICE: Doppler Endoscopic Probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Imaging and Biomarker Analyses (CIBER)
Status: UNKNOWN
Conditions: Coronary Artery Disease|Heart Diseases|Heart Failure
Interventions: DIAGNOSTIC_TEST: Echocardiography|DIAGNOSTIC_TEST: magnetic resonance imaging|DIAGNOSTIC_TEST: computed tomography|DIAGNOSTIC_TEST: blood withdrawl
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of a Probiotic With High Beta-galactosidase Activity on Patients With Lactose Intolerance
Status: COMPLETED
Conditions: Lactose Intolerance
Interventions: DIETARY_SUPPLEMENT: Tropical juice with probiotics (B.coagulans)|OTHER: a Tropical juice with no probiotics|OTHER: lactase tablet|OTHER: placebo tablet (cornstarch)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Intracranial Hematoma Aspiration for Spontaneous Intracerebral Hemorrhage
Status: RECRUITING
Conditions: Spontaneous Cerebral Hemorrhage
Interventions: PROCEDURE: Minimally invasive hematoma aspiration drainage combined with urokinase injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ALIGN: Aligning Medications With What Matters Most (Demonstration)
Status: RECRUITING
Conditions: Polypharmacy|Alzheimer's Disease and Related Dementias|Mild Cognitive Impairment
Interventions: BEHAVIORAL: Pharmacist-led deprescribing intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Efficacy of Telaprevir in Combination With Peginterferon Alfa-2a and Ribavirin in Subjects Co-Infected With Hepatitis C Virus (HCV) and HIV
Status: COMPLETED
Conditions: Hepatitis C|HIV Infections
Interventions: DRUG: telaprevir or matching placebo|DRUG: telaprevir or matching placebo|BIOLOGICAL: peginterferon alfa-2a|DRUG: ribavirin (fixed dose)|DRUG: ribavirin (weight-based dose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Lenses on Musculoskeletal and Visual Complaints in VDU Workers With Neck Complaints
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: VDU lenses (Zeiss® Officelens Plus)|OTHER: Progressive lenses (Zeiss® Multifocal Precision Plus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Status: RECRUITING
Conditions: Neovascular Age-related Macular Degeneration (nAMD)
Interventions: DRUG: AR-14034 SR implant lower dose|DRUG: Aflibercept Injection|DRUG: Sham procedure|DRUG: AR-14034 SR implant higher dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rapid Urease Test for Diagnosis of H. Pylori Infection in Patients With Peptic Ulcer Bleeding
Status: COMPLETED
Conditions: Peptic Ulcer|Hemorrhage
Interventions: PROCEDURE: endoscopic biopsy|PROCEDURE: endoscopic biopsy|PROCEDURE: endoscopic biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
Status: COMPLETED
Conditions: NSAIDs|Upper GI Symptoms
Interventions: DRUG: Esomeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Overall Survival of Meclinertant Versus Placebo After a First Line Chemotherapy With Cisplatin + Etoposide
Status: COMPLETED
Conditions: Lung Cancer|Pulmonary Neoplasms|Small Cell Lung Cancer
Interventions: DRUG: SR48692
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HR021618 in Moderate to Severe Pain After Abdominal Surgery
Status: UNKNOWN
Conditions: Pain After Abdominal Surgery
Interventions: DRUG: HR021618|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Syringe Pressure Analysis: A Critical Examination of the Operator's Burden
Status: COMPLETED
Conditions: Back Pain Lower Back Chronic
Interventions: OTHER: Analysis of Force and Pressure Requirements across Syringe Sizes for Pain Management Procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Patient Reported Visual Satisfaction Following Same Day or Delayed Bilateral Cataract Surgery
Status: UNKNOWN
Conditions: Bilateral Cataract|Charles Bonnet Syndrome
Interventions: PROCEDURE: Immediate sequential bilateral cataract surgery (ISBCS)|PROCEDURE: Delayed sequential bilateral cataract surgery (DSBCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Early-onset Ventilator-associated Pneumonia in Adults: Comparison of 8 Versus 15 Days of Antibiotic Treatment
Status: COMPLETED
Conditions: Pneumonia Ventilator Associated
Interventions: DRUG: Augmentin, Ceftriaxone, Cefotaxime, netilmycin, tobramycin|DRUG: compare 8 to15 days of antibiotic treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Equine Assisted Occupational Therapy, for Children With Attention Deficit Hyperactivity Disorder (ADHD) on Cognitive-emotional Aspects, Daily Function and Participation
Status: RECRUITING
Conditions: Attention-deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: The efficacy of Equine Assisted Occupational Therapy, for children with Attention Deficit Hyperactivity Disorder (ADHD) on cognitive-emotional aspects, daily function and participation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Activity and Life-role Targeted Pain Rehabilitation in Primary Health Care
Status: TERMINATED
Conditions: Musculoskeletal Neck Pain|Musculoskeletal Shoulder Pain
Interventions: OTHER: Activity targeted pain rehabilitation|OTHER: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate ARD-501 in Patients With Autism Spectrum Disorder
Status: RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Low Dose ARD-501|DRUG: High Dose ARD-501|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and EV With Radiation Therapy for MIBC Patients (PEVRAD)
Status: RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: MK-3475|DRUG: ASG-22CE|PROCEDURE: maximal TURBT|RADIATION: Radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Air Barrier System for the Prevention of Prosthesis-related Infections
Status: UNKNOWN
Conditions: Prosthesis-Related Infections
Interventions: DEVICE: ABS deployed and active|DEVICE: ABS deployed and NOT active
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of KBP-5074 Tablet vs Capsule Formulations
Status: COMPLETED
Conditions: Bioequivalence
Interventions: DRUG: KBP-5074 Capsule|DRUG: KBP-5074 Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Indirect Approach of C0-1 and C2-3 Segments in Flexion-rotation Test
Status: UNKNOWN
Conditions: Neck Pain|Cervical Spine Disease|Rotation
Interventions: OTHER: Manual therapy techniques in C0-1 and C2-3 with cervical exercise|OTHER: Cervical Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Honey Versus Povidone-iodine on Laceration Wounds
Status: COMPLETED
Conditions: Laceration Face|Wound Heal|Wounds and Injuries|Laceration Arm|Laceration of Leg
Interventions: OTHER: Honey|OTHER: Povidone-iodine|OTHER: Paraffin gauze
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of LVEF by a New Automatic Evaluation Tool in a Pocket Ultrasound Scanner
Status: COMPLETED
Conditions: Echocardiography|Medicine, Emergency|Technology Assessment, Biomedical|Heart Diseases
Interventions: PROCEDURE: echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nature of Anifrolumab Impact on Vaccine-Emergent Immunity in SLE
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus (SLE)
Interventions: DRUG: Anifrolumab|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SHR-1210 in Combination With Apatinib in Patients With Metastatic, Persistent, or Recurrent Cervical Cancer
Status: COMPLETED
Conditions: Recurrent Cervical Carcinoma|Metastatic Cervical Cancer
Interventions: DRUG: SHR-1210|DRUG: Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Is There an Allergy to Pure Metallic Gold Microparticles?
Status: NOT_YET_RECRUITING
Conditions: Allergic Reaction
Interventions: OTHER: Gold microparticles|OTHER: Gold thiosulphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: An Exploratory Clinical Study Evaluating the Safety and Efficacy of Anti CD30 CAR T Cells in Patients With CD30+ Relapsed/Refractory Lymphoma
Status: UNKNOWN
Conditions: Hodgkin Lymphoma|NK/T Cell Lymphoma|Peripheral T Cell Lymphoma, Unspecified|Angioimmunoblastic T-cell Lymphoma|Anaplastic Large Cell Lymphoma|Diffuse Large B Cell Lymphoma|Mediastinal B-Cell Diffuse Large Cell Lymphoma|Gray Zone Lymphoma
Interventions: BIOLOGICAL: Anti CD30 CAR-T Cell Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Polygenic Risk Score|DIAGNOSTIC_TEST: Coronary Calcium Score
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of YW17 (Laronidase-CinnaGen) Compared to Aldurazyme® in MPS I Patients
Status: COMPLETED
Conditions: Mucopolysaccharidosis Type 1
Interventions: BIOLOGICAL: Laronidase|DRUG: Antihistamine|DRUG: Antipyretic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults
Status: COMPLETED
Conditions: Aging|Benzodiazepine Sedative Adverse Reaction|Anticholinergic Adverse Reaction|Adverse Drug Event
Interventions: OTHER: Order Entry|OTHER: Open Encounter|OTHER: Follow-up booster Alert|OTHER: Cold State outreach|OTHER: Simplified|OTHER: Sign-off alert|OTHER: Pre-commitment|OTHER: Different Risks|OTHER: Standard Epic Basic Alert|OTHER: Enhanced Alert
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma|Ocular Hypertension
Interventions: DRUG: Fixed-Combination Bimatoprost/Brimonidine|DRUG: Bimatoprost Ophthalmic Solution 0.01%|DRUG: Vehicle Ophthalmic Solution|DRUG: Brimonidine Tartrate Ophthalmic Solution 0.2%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electronic Optimization of Inspired Oxygen During Mechanical Ventilation, a Pragmatic Randomized Trial (OPTI-Oxygen)
Status: RECRUITING
Conditions: Hyperoxia
Interventions: OTHER: FiO2 titration using electronic alert system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Pain Management Using the ARCHIMEDES® Constant-Flow Infusion Pump System for Intrathecal Delivery
Status: COMPLETED
Conditions: Chronic Pain
Interventions: DEVICE: Archimedes Constant Flow Implantable Pump
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disposable Energy Sources and Operating Room Time for Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Benign Uterine Disease
Interventions: DEVICE: disposable device (Ligasure, Covidien)|DEVICE: Reusable device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Cognitive Behavioral Therapy (CBT) on Weight Maintenance After Successful Weight Loss
Status: COMPLETED
Conditions: Obesity|Overweight
Interventions: BEHAVIORAL: CBT + Hypo-energetic Diet|BEHAVIORAL: Hypo-energetic Diet only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Tumor Treating Fields Combined With Gemcitabine and Albumin-bound Paclitaxel in the First-line Treatment of Locally Advanced Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Pancreatic Cancer
Interventions: DEVICE: Tumor treating fields combined with Gemcitabine hydrochloride and albumin binding paclitaxel|DRUG: Gemcitabine hydrochloride and albumin binding paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: SB010|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic or Locally Advanced Unresectable Solid Tumors
Interventions: DRUG: M1774|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Perioperative Duloxetine as a Part of Multimodal Analgesia in Laparoscopic Colorectal Cancer Surgery
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: Duloxetine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Body Cooling During Carotid Endarterectomy: No-profit, Open, Mono-centric, Feasibility Study
Status: COMPLETED
Conditions: Carotid Artery Diseases|Hypothermia|Stroke|Carotid Artery Plaque|Carotid Artery Stenosis|Cerebrovascular Accident
Interventions: DEVICE: endovascular cooling (Zoll system)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: OTHER: Discontinuation of hypertonic saline (HS)|OTHER: Continuation of hypertonic saline (HS)|OTHER: Discontinuation of dornase alfa (dnase)|OTHER: Continuation of dornase alfa (dnase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Phase-II Study of SU011248 (Sunitinib)in Male Patients With Relapsed or Cisplatin-Refractory Germ Cell Cancer
Status: COMPLETED
Conditions: Relapsed or Cisplatin-Refractory Germ Cell Cancer
Interventions: DRUG: SU011248 (Sunitinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Efficacy and Safety of TT-00420 (Tinengotinib) as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Cholangiocarcinoma|Biliary Tract Cancer|HER2-negative Breast Cancer|Triple Negative Breast Cancer|Small-cell Lung Cancer|Bladder Cancer|Prostate Cancer|Thyroid Cancer|Gastric Cancer|Gallbladder Cancer
Interventions: DRUG: TT-00420|DRUG: Combination Product: Atezolizumab|DRUG: Combination Product: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detecting the Impact of Statin Therapy On Lowering Risk of Venous Thrombo-Embolic Events (DISOLVE)
Status: COMPLETED
Conditions: Venous Thromboembolism|Deep Vein Thrombosis|Neoplasms
Interventions: DRUG: Rosuvastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of Pasireotide LAR in Combination With Everolimus in Advanced Metastatic NETs
Status: COMPLETED
Conditions: Gastroenteropancreatic Neuroendocrine Tumor of the Pulmonary ot Gastroenteropancreatic System
Interventions: DRUG: Pasireotide LAR followed by Pasireotide LAR + Everolimus|DRUG: Everolimus followed by Pasireotide LAR + Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Structuralised Sick-leave Program Compared to Usual Care Sick Leave Management in Patients After an Acute Myocardial Infarction
Status: UNKNOWN
Conditions: Myocardial Infarction
Interventions: OTHER: Usual care sick-leave management|OTHER: Structuralised sick-leave program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Pyrotinib in Combination With Nab-paclitaxel in Patients With HER2-positive Advanced Breast Cancer: an Exploratory Study
Status: UNKNOWN
Conditions: HER2-positive Breast Cancer
Interventions: COMBINATION_PRODUCT: pyrotinib maleate tablets+nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Divalproex Sodium on Food Intake, Energy Expenditure, and Posture Allocation
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: divalproex sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Study to Assess the Effect of Meplazumab on COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Meplazumab for Injection|DRUG: Sterile normal saline (0.9%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pioglitazone/Metformin Combination Therapy in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia.
Status: COMPLETED
Conditions: Diabetes Mellitus|Dyslipidemias
Interventions: DRUG: Pioglitazone and Metformin|DRUG: Glimepiride and Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Leucine Enriched Amino Acids on Myofibrillar and Collagen Protein Synthesis
Status: ACTIVE_NOT_RECRUITING
Conditions: Interventional
Interventions: DIETARY_SUPPLEMENT: Leucine enriched amino acids|DIETARY_SUPPLEMENT: Carbohydrate Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Chlorambucil Versus Chlorambucil Plus Rituximab Versus Rituximab in MALT Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Mucosa-Associated Lymphoid Tissue
Interventions: DRUG: chlorambucil (drug)|DRUG: rituximab+chlorambucil|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Adjuvant Transarterial Chemoembolization (TACE) for Preventing Tumor Recurrence After Liver Resection
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: epirubicin and lipiodol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Pumps on Internal Thoracic Arteries (IPITA)
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DIAGNOSTIC_TEST: vascular reactivity of internal thoracic arteries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Iyengar Yoga Therapy in the Management of Stress Urinary Incontinence Among Young Females
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: BEHAVIORAL: iyengar yoga
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Superficial Vein Thrombosis (SVT) Treated With Rivaroxaban Versus Fondaparinux
Status: COMPLETED
Conditions: Superficial Vein Thrombosis
Interventions: DRUG: Rivaroxaban|DRUG: Fondaparinux
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers
Status: COMPLETED
Conditions: Nasolabial Folds|Lipoatrophy|Lipodystrophy
Interventions: DRUG: TAT4 Gel concentration A|DRUG: TAT4 Gel concentration B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD)
Status: UNKNOWN
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: Agomelatine|DRUG: Escitalopram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: sevoflurane|DRUG: midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety, Tolerability, PK and PD of PB2452 in Healthy Younger, Older and Elderly Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: PB2452 Infusion|DRUG: Placebo - Sodium Chloride|DRUG: Ticagrelor Oral Tablet - Pre-Treatment|DRUG: Ticagrelor Oral Tablet - Pre-Treatment and Post-Treatment|DRUG: Ticagrelor Oral Tablet - Pre-Treatment|DRUG: PB2452 Infusion|DRUG: Placebo - Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chromosome 18 Clinical Research Center
Status: RECRUITING
Conditions: Chromosome Aberrations|Growth Hormone Deficiency|Hypomyelination
Interventions: PROCEDURE: Determination of growth hormone status|PROCEDURE: Measurement of growth, thyroid and sex hormone levels|PROCEDURE: Behavior and neuropsychometric evaluations|PROCEDURE: Audiological and ear, nose and throat examination|PROCEDURE: Magnetic resonance imaging of the brain|PROCEDURE: Dysmorphology evaluation|PROCEDURE: Neurology examination|PROCEDURE: Dental evaluation|PROCEDURE: Speech pathology evaluation|PROCEDURE: Psychiatric evaluation|PROCEDURE: Orthopedic evaluation|PROCEDURE: Ophthalmologic evaluation|PROCEDURE: Gastrointestinal evaluation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nuvigil in Treatment of Cancer-Related Fatigue in Chronic Myeloid Leukemia Patients
Status: TERMINATED
Conditions: Chronic Myeloid Leukemia
Interventions: DRUG: Placebo|DRUG: Armodafinil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Bronchial Drainage Technique by the Medical Device Simeox® on Respiratory Function and Symptoms in Adult Patients With Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: DEVICE: SIMEOX|OTHER: Autogenic drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Smart Scales for Weight Gain Prevention in African American Breast Cancer Survivors
Status: COMPLETED
Conditions: Body Weight Changes|Breast Neoplasms
Interventions: BEHAVIORAL: Self-regulation plus activity monitoring|BEHAVIORAL: Self-regulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Microbiome/Peptidome-based Model for Non-invasive Detection of High-risk Gastroesophageal Varices in Compensated Cirrhosis (CHESS1901/APPHA1901)
Status: UNKNOWN
Conditions: Compensated Cirrhosis
Interventions: DIAGNOSTIC_TEST: esophagogastroduodenoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of Food Intake on the Pharmacokinetic of Single Dose SPH3127 Tablets in Chinese Health Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: SPH3127 200mg Panel A|DRUG: SPH3127 200mg Panel B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrome
Status: TERMINATED
Conditions: Restless Legs Syndrome
Interventions: DRUG: BP 1.4979|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Dry Needling Versus Strain-counterstrain on the Upper Trapezius
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Dry needling|OTHER: Strain-counterstrain technique|OTHER: Placebo manual technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Antihypertensive Agents Concerning With Hemodynamics and Reduction of Anaesthetics in Orthognathic Surgery
Status: COMPLETED
Conditions: Orthognathic Surgery
Interventions: DRUG: b-blocker(Atenolol)|DRUG: ACE inhibitor(Enapril)|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: TAP Block Alone Versus TAPblock With Rectus Sheath Block in Liposuction Surgery
Status: UNKNOWN
Conditions: Pain
Interventions: PROCEDURE: Transversus abdominis plane block|PROCEDURE: rectus sheath block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Study of Experimental Dental Adhesive With and Without Phosphoric Acid Pretreatment
Status: COMPLETED
Conditions: Dental Caries
Interventions: DEVICE: Experimental adhesive w/out phosphoric acid in post. rest.|DEVICE: Experimental adhesive with phosphoric acid in post. rest.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma
Status: RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: Pentoxifylline|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMJ-1001 Bruxism Run-In/Pivotal Trial
Status: WITHDRAWN
Conditions: Bruxism
Interventions: DEVICE: TMJ(TM) NextGeneration|DEVICE: Standard Hard TMJD Splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Obesity-related Cancers: Setting up of a Multi-Cancer Education and Prevention Program in Hong Kong
Status: UNKNOWN
Conditions: Obesity|Colorectal Cancer|Prostate Cancer|Breast Cancer
Interventions: DIAGNOSTIC_TEST: Faecal Immunochemical Test|DIAGNOSTIC_TEST: Prostate-Specific Antigen Test|DIAGNOSTIC_TEST: Mammogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Phase 1 Pilot Study of 4-MP to Treat Stargardt Macular Dystrophy
Status: COMPLETED
Conditions: Macular Dystrophy, Corneal
Interventions: DRUG: 4-Methylpyrazole|OTHER: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Aerobic Exercise to Mitigate Hyperglycemia After Fasted Resistance Exercise
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: BEHAVIORAL: Resistance exercise only|BEHAVIORAL: Resistance exercise plus cool down
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S. Aureus Decolonization in HPN Patients.
Status: TERMINATED
Conditions: Staphylococcus Aureus|Motility Disorder
Interventions: DRUG: Doxycycline|DRUG: Trimethoprim|DRUG: Sulfamethoxazole/trimethoprim|DRUG: Clindamycin|DRUG: Clarithromycin|DRUG: Ciprofloxacin|DRUG: Fusidic Acid|DRUG: Rifampin|DRUG: Chlorhexidine|DRUG: Mupirocin|DRUG: Betadine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pilot Study of Bupivacaine Infusion in Abdominal Surgery
Status: UNKNOWN
Conditions: Laparoscopic Surgical Procedures
Interventions: DRUG: bupivicaine|OTHER: Saline infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Itraconazole to Prevent Recurrent Barrett's Esophagus
Status: RECRUITING
Conditions: Barrett Oesophagitis With Dysplasia
Interventions: DRUG: Itraconazole in capsule form|DRUG: Itraconazole in solution form
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Comparative Study Between Laryseal Pro Supra Glottic Device (SGD) With Proseal Laryngeal Mask Airway
Status: COMPLETED
Conditions: Ophthalmic Surgery
Interventions: DEVICE: Laryseal pro supra glottic device|DEVICE: Laryngeal Mask Airway- Proseal™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effects of Acute Total Sleep Deprivation Versus Normal Sleep on Metabolism
Status: COMPLETED
Conditions: Sleep Deprivation|Sleep
Interventions: BEHAVIORAL: Inhibitory task|PROCEDURE: Blood samples|PROCEDURE: Tissue samples|PROCEDURE: Oral glucose tolerance test|BEHAVIORAL: Portion Size Task
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy of Multiple Doses of Ketorolac Tromethamine Administered Intranasally for Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Ketorolac tromethamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Befotertinib and Icotinib for NSCLC With Uncommon EGFR Mutations
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic|EGFR G719X|EGFR L861Q|EGFR S768I
Interventions: DRUG: Icotinib|DRUG: Befotertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Cardiovascular Impacts of Electronic Cigarettes in Comparison to the Use of Nicotine Replacement Patches
Status: COMPLETED
Conditions: Smoking, Tobacco
Interventions: DEVICE: Electron Cigarette|DEVICE: Nicotine Replacement Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Blood Biomarkers Based Screening for HPV-driven OPC
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma|Anal Cancer|Human Papilloma Virus
Interventions: DIAGNOSTIC_TEST: HPV16-E6 serology and HPV ctDNA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome
Status: UNKNOWN
Conditions: Interstitial Cystitis|Bladder Pain Syndrome|Painful Bladder Syndrome|Chronic Interstitial Cystitis
Interventions: DRUG: AQX-1125 100 mg|DRUG: AQX-1125 200 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Messaging Interventions to Reduce Alcohol Problems Project
Status: UNKNOWN
Conditions: Alcohol-Related Disorders|Alcohol Use Disorders|Alcohol Drinking|Alcoholism|Alcohol Abuse
Interventions: BEHAVIORAL: Drink Tracking (MA)|BEHAVIORAL: Adaptive Tailored (TA)|BEHAVIORAL: Tailored (TO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety and Efficacy of 4 Doses of BI 1744 CL Delivered Via the Respimat in Patients With Asthma.
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Placebo|DRUG: Olodaterol (BI 1744) high|DRUG: Olodaterol (BI 1744) medium|DRUG: Olodaterol (BI 1744) very low|DRUG: Formoterol 12 mcg|DRUG: Olodaterol (BI 1744) low
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Skeletal Muscle-derived Cell Implantation for Treatment of Fecal Incontinence
Status: RECRUITING
Conditions: Fecal Incontinence
Interventions: BIOLOGICAL: aSMDC|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Mometasone Furoate Plus Azelastine HCl Combination Versus Mometasone Furoate Alone or Azelastine Alone in Patients With Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: mometasone furoate plus azelastine HCl|DRUG: mometasone furoate|DRUG: azelastine HCl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: REACH-OUT: Chicago Children's Diabetes Prevention Program
Status: COMPLETED
Conditions: Obesity|Type 2 Diabetes
Interventions: BEHAVIORAL: Reach-Out Program, nutritional and exercise program|BEHAVIORAL: Reach-In Program, standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours
Status: RECRUITING
Conditions: Advanced Cancer|Advanced Solid Tumor|Neoplasm Malignant|Metastatic Cancer|Melanoma|Classical Hodgkin Lymphoma|Non Small Cell Lung Cancer|Renal Cell Carcinoma|Urothelial Carcinoma|Head and Neck Squamous Cell Carcinoma|Subungual Squamous Cell Carcinoma|Oesophageal Carcinoma|MSI-H Colorectal Cancer|Gastric Cancer|Triple Negative Breast Cancer|Endometrial Carcinoma|Pleural Mesothelioma
Interventions: DRUG: Fosifloxuridine Nafalbenamide|DRUG: Leucovorin|DRUG: Pembrolizumab|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Endotracheal Tube Fixation Methods in Prone Position
Status: COMPLETED
Conditions: Fixation Device; Complications
Interventions: OTHER: thomas fixation|OTHER: elastic band|OTHER: normal fixation adhesive tape|OTHER: reinforced adhesive tape fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Omega-3 and Therapy Study for Childhood Bipolar Disorder- Not Otherwise Specified
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: DRUG: Omega-3 Supplementation|BEHAVIORAL: Psychoeducational Psychotherapy (PEP)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy Men to Test How Well Different Doses of BI 1839100 Are Tolerated (1490-0001)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1839100|DRUG: Placebo|DRUG: allyl isothiocyanate (AITC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2a Study to Evaluate the Effect of Rilapladib (SB-659032) in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: 250mg rilapladib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Safety and Immunogenicity Study of HIV p17/p24:Ty-VLP in HIV-1 Seronegative Subjects
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: HIV p17/p24:Ty-VLP|BIOLOGICAL: Aluminum hydroxide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Study of Bevacizumab Combined With Capecitabine and Either Oxaliplatin or Irinotecan as First Course of Treatment for Patients With Colorectal Cancer That Has Spread Beyond the Colon
Status: TERMINATED
Conditions: Colorectal Neoplasms
Interventions: DRUG: Bevacizumab|DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Intensive Care Unit Continuous Glucose Monitoring
Status: UNKNOWN
Conditions: Hyperglycemia|Hypoglycemia
Interventions: OTHER: Current UVA intensive care insulin protocol|OTHER: Current UVA intensive care insulin protocol with "brakes"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers
Status: UNKNOWN
Conditions: Mutation|Genetic Syndrome
Interventions: OTHER: Screening of adult without diagnosis of PH carrying an heterozygous EIF2AK4 mutation.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study in Healthy Participants to Assess the Effect of Darunavir, Emtricitabine, and Tenofovir Alafenamide in the Presence of Cobicistat When Administered as a Fixed Dose Combination (Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide) Compared to the Co-administration of the Separate Agents
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide FDC|DRUG: Darunavir|DRUG: Emtricitabine/Tenofovir Alafenamide|DRUG: Cobicistat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products
Status: TERMINATED
Conditions: ALS|Autism Spectrum Disorder|Cancer|Spasticity, Muscle|Dyskinetic Syndrome|Epilepsy|Glaucoma|Huntington Disease|Inflammatory Bowel Disease (IBD)|Multiple Sclerosis|Neuropathy|Opioid Use|Parkinson Disease|HIV/AIDS|Ptsd|Intractable Pain|Sickle Cell Disease|Terminal Illness
Interventions: OTHER: Registry|OTHER: PK microsampling of blood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Presence of PTSD and Emotion Dysregulation Among Inpatients With Substance Use Disorder
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder|Substance Use Disorders|Emotion Regulation|Suicide|Self-harm
Interventions: BEHAVIORAL: Narrative Exposure Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study
Status: RECRUITING
Conditions: Endometriosis|Post Operative Pain
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Use of 4,4'-Dihydroxybenzophenone-2,4-Dinitrophenylhydrazone (A-007) in the Treatment of Advanced Malignancies Including Kaposi's Sarcoma and Lymphoproliferative Disorders
Status: COMPLETED
Conditions: Sarcoma, Kaposi|HIV Infections|Lymphoproliferative Disorders
Interventions: DRUG: A-007
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT