pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Early Phase Evaluation of ABC294640 in Patients With Refractory/Relapsed Diffuse Large B-cell Lymphoma or Kaposi Sarcoma
Status: WITHDRAWN
Conditions: Diffuse Large B Cell Lymphoma|Kaposi Sarcoma
Interventions: DRUG: ABC294640
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NSAID Use and Healing After Tibia Fractures and Achilles Tendon Ruptures
Status: UNKNOWN
Conditions: Musculoskeletal Injury
Interventions: DRUG: Ibuprofen 600 mg|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants With Vascular Disease, The VERTIS CV Study (MK-8835-004)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Ertugliflozin|DRUG: Placebo|DRUG: Glycemic Rescue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided TAP Block and Spinal Morphine for Pain Relief After Caesarean Section
Status: COMPLETED
Conditions: Post Operative Pain
Interventions: PROCEDURE: Ultrasound-Guided Transversus Abdominis Plane Block|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Ciclesonide Nasal Spray in Participants With Seasonal Allergic Rhinitis (SAR) in Russia
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Ciclesonide|DRUG: Ciclesonide Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Superficial Cervical Plexus Block for Neck and Shoulder Pain
Status: COMPLETED
Conditions: Neck Pain|Shoulder Pain
Interventions: OTHER: Superficial cervical plexus block|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Autism MEAL Plan: Parent Training to Manage Eating Aversions & Limited Variety
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: Autism MEAL Plan|BEHAVIORAL: Parent Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MOMs Chat and Care Study
Status: RECRUITING
Conditions: Severe Maternal Morbidity
Interventions: OTHER: Northwell Pregnancy & Peds Chats|BEHAVIORAL: Prenatal Telehealth Visits|OTHER: Postpartum Telehealth Visits|OTHER: Home Blood Pressure Monitor|OTHER: Fitbit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Early Enteral Feeding After Pylorus Preserving Pancreatoduodenectomy
Status: UNKNOWN
Conditions: Pancreas Cancer|Bile Duct Cancer|Ampulla of Vater Cancer
Interventions: PROCEDURE: Enteral Feeding and Total Parental Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Beneficial Effect of Probiotics on DKD Patients and the Role of Gut Microbiota Modulation
Status: RECRUITING
Conditions: Diabetic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: Probiotic group|OTHER: Placebo group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of Elemental Impurities Level After Multiple Administration of DWJ1230 or DWB2001 in Subjects With Functional Diarrhea or Irritable Bowel Syndrome With Predominant Diarrhea.
Status: COMPLETED
Conditions: Diarrhea
Interventions: DRUG: DWJ1230|DRUG: DWB2001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy Between a Newly Designed Covered Stent and Uncovered Stent for Malignant Colorectal Obstruction
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: PROCEDURE: self-expandable metal stent insertion(covered stent)|PROCEDURE: self-expandable metal stent insertion(uncovered stent)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction
Status: TERMINATED
Conditions: Diastolic Heart Failure|Hypertension
Interventions: PROCEDURE: renal denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Rebamipide Eye Drops to Treat Dry Eye
Status: COMPLETED
Conditions: Keratoconjunctivitis Sicca
Interventions: DRUG: Rebamipide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supervised Exercises Compared With Radial Extracorporal Shock Wave Therapy (rESWT) in Patients With SIS
Status: UNKNOWN
Conditions: Shoulder Pain
Interventions: PROCEDURE: Physical therapy method called Supervised Exercises|PROCEDURE: Radial Extracorporeal Shockwave Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Dry Eye Syndrome on Metrics of Low Contrast Vision Before and After Meibomian Gland Expression
Status: COMPLETED
Conditions: Meibomian Gland Dysfunction
Interventions: PROCEDURE: Meibomian gland (MG) expression
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: HTX-011|DRUG: Bupivacaine HCl|DRUG: Saline placebo|DEVICE: Luer-lock applicator|DEVICE: Vial access device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immunotoxin Therapy in Treating Patients With Advanced Cancer
Status: COMPLETED
Conditions: Cervical Cancer|Fallopian Tube Cancer|Head and Neck Cancer|Lung Cancer|Malignant Mesothelioma|Ovarian Cancer|Pancreatic Cancer|Primary Peritoneal Cavity Cancer
Interventions: BIOLOGICAL: SS1(dsFv)-PE38 immunotoxin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Drug Monitoring to oPtimize ANtiretroviral regimeNs in HIV-infected Women Who wAnt to Breastfeed
Status: RECRUITING
Conditions: HIV-1-infection
Interventions: DIAGNOSTIC_TEST: Therapeutic drug monitoring in plasma of mother and child and in breastmilk
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Creatine Effect on Brown Adipose Tissue Activation
Status: COMPLETED
Conditions: Diet-induced Thermogenesis|Brown Adipose Tissue Activation
Interventions: DIETARY_SUPPLEMENT: Creatine monohydrate|DIETARY_SUPPLEMENT: placebo cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: ELTGOL and Bronchiectasis. Respiratory Therapy
Status: COMPLETED
Conditions: Respiratory; Complications, Therapy|Bronchiectasis
Interventions: PROCEDURE: Low Expiration Open glottis inferolateral (ELTGOL)|PROCEDURE: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Suction Drain Versus the Use of Adaptive Skin Sutures After Mastectomy ± Axillary Lymphadenectomy; a Prospective Randomised Study
Status: UNKNOWN
Conditions: in Situ Breast Cancer|Invasive Breast Cancer
Interventions: PROCEDURE: Insertion of suction drain(s) following mastectomy|PROCEDURE: Adaptive skin sutures.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Two Way Crossover Closed Loop MPC vs Control IQ
Status: RECRUITING
Conditions: Type 1 Diabetes
Interventions: DEVICE: MPC closed-loop system|DEVICE: t:slim X2 pump with Dexcom G6 CGM and Control IQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PEARL-SC Trial: A Study of the Efficacy, Safety, and Tolerability of A 623 Administration in Subjects With Systemic Lupus Erythematosus
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: A-623|DRUG: A-623|DRUG: A-623|OTHER: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Pharmacokinetics and Pharmacodynamics of Tiotropium With Ipratropium or Placebo After 19 Days of Tiotropium Treatment
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ipratropium - unit dose vial|DRUG: Tiotropium - inhalation capsule|DRUG: Placebo matching tiotropium|DRUG: Placebo matching ipratropium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: E3 Breast Cancer Taxotere Combination
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: Vandetanib (ZD6474)|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cefadroxil 500 mg Capsules in Normal Healthy Non-Smoking Male and Female Subjects.
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefadroxil 500 mg Capsules|DRUG: DURICEF® capsules 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impacts of Different Pressure Pneumoperitoneum on Myocardial and Pulmonary Injuries After Robot-assisted Surgery
Status: UNKNOWN
Conditions: Prostatic Neoplasms|Urinary Bladder Neoplasms
Interventions: PROCEDURE: low-pressure pneumoperitoneum|PROCEDURE: standard-pressure pneumoperitoneum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts
Status: RECRUITING
Conditions: Aortic Aneurysm, Thoracoabdominal|Aortic Aneurysm, Thoracic|Aortic Dissection, Thoracoabdominal
Interventions: DEVICE: Endovascular treatment of Thoracoabdominal Aortic Aneurysm|DEVICE: Endovascular treatment of Aortic Arch Aneurysms
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Osteoporosis
Status: SUSPENDED
Conditions: Osteoporosis
Interventions: BIOLOGICAL: AlloRx
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multisensory Stimulation Versus White Noise
Status: COMPLETED
Conditions: Retinopathy|Premature Retinopathy
Interventions: BEHAVIORAL: Multisensorial Stimulation|BEHAVIORAL: White Noise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems
Status: RECRUITING
Conditions: Deprescriptions|Polypharmacy|Primary Health Care|Community Pharmacy Services
Interventions: OTHER: Clinical medication review focused on deprescribing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Topotecan and Paclitaxel in Treating Patients With Recurrent or Refractory Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: paclitaxel|DRUG: topotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET/CT Imaging of Angiogenesis in Patients With Neuroendocrine Tumors Using 68Ga-NODAGA-E[c(RGDyK)]2
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: One injection of 68Ga-NODAGA-E[c(RGDyK)]2|DEVICE: PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Autologous Bone Marrow Transplantation in Acute Non-Lymphoblastic Leukemia During First or Subsequent Remission
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute|Leukemia|Blood and Marrow Transplant (BMT)
Interventions: PROCEDURE: high dose chemotherapy then autologous hematopoietic cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DCEP in Combination With Thalidomide as Salvage Therapy for Post Transplantation Relapse
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Thalidomide|DRUG: Dexamethasone|DRUG: Cytoxan|DRUG: Etoposide|DRUG: Cisplatin|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement Properties in People With Hemophilia
Status: NOT_YET_RECRUITING
Conditions: Hemophilia A|Hemophilia B|Musculoskeletal Complication|Measurement Error
Interventions: OTHER: Measurement Properties (Reliability and Validity) of a Set of Assessments evaluating Physical Function in adult Participants with Hemophilia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: First-line Antibiotic Therapy for Early-stage HP(+) Gastric Pure DLBCL
Status: RECRUITING
Conditions: Gastric Diffuse Large B-cell Lymphoma
Interventions: DRUG: Lansoprazole, Amoxicillin, Clarithromycin, Metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Impact of Routine "Clinical Cancer Department/Supportive Care Department" Consultation on the Prescription of an Additional Line of Chemotherapy
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: OTHER: Action Group|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Rediscovering Hydroxychloroquine as a Novel Insulin Sensitizer
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Hydroxychloroquine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Visual Performance of Senofilcon A With and Without a New UV/HEV-filter
Status: COMPLETED
Conditions: Visual Performance
Interventions: DEVICE: TRP-200|DEVICE: ACUVUE Oasys 1-Day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Valproate Versus Levetiracetam Monotherapy on Reproductive Functions in Epileptic Males
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Effect of valporate on Reproductive Functions in Newly Diagnosed Epileptic Males|DRUG: Effect of levetiracetam on epileptic males reproductive function
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effectiveness of Diode Laser and Sclerotherapy in Treatment of Oral Pyogenic Granuloma
Status: COMPLETED
Conditions: Pyogenic Granuloma of Gingiva
Interventions: PROCEDURE: diode laser application|PROCEDURE: intra-lesional injection of ethanolamine oleate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Multiple-Dose TAK-058 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TAK-058|DRUG: TAK-058 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transrectal Vacuum Assisted Drainage: A New Method of Treating Anastomotic Leakage After Rectal Resection
Status: UNKNOWN
Conditions: Colorectal Surgery
Interventions: PROCEDURE: Transrectal vacuum assisted drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Edoxaban for the Treatment of Coagulopathy in Patients With Active Cancer and Acute Ischemic Stroke: a Pilot Study. (ENCHASE Study)
Status: UNKNOWN
Conditions: Correction of Cancer-related Coagulopathy With Novel Oral Anticoagulant (Edoxaban)
Interventions: DRUG: Edoxaban|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis
Status: COMPLETED
Conditions: Vaginitis
Interventions: DRUG: Polygynax combinaison of polymyxin, Neomycin and Nystatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study on Prodovite® VMP35 Supplement on Athletic Performance
Status: UNKNOWN
Conditions: Athletic Performance
Interventions: DIETARY_SUPPLEMENT: Clinical Investigation on Enhanced Sports Nutrition and Performance Activities by Prodovite VMP35 Supplement|DIETARY_SUPPLEMENT: Broad Spectrum Safety
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: PET/MR Versus CECT Scans in Imaging Patients With Ovarian Cancer or Highly Suspected Ovarian Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Ovarian Neoplasm|Ovarian Carcinoma
Interventions: RADIATION: Dynamic Enhanced CT|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 18F-FMAU PET/CT in Imaging Patients With Advanced Cancers
Status: TERMINATED
Conditions: Malignant Neoplasm
Interventions: RADIATION: fluorine F 18 d-FMAU|PROCEDURE: positron emission tomography|PROCEDURE: computed tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 24 Week Study to Compare Systemic VEGF-levels of Ranibizumab and Aflibercept in DME.
Status: WITHDRAWN
Conditions: Visual Impairment Due to Diabetic Macular Edema
Interventions: DRUG: Ranibizumab|DRUG: Aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mouthwash With Chlorhexidine 0.12%/Ethyl Alcohol 7% Compared to Ethyl Alcohol 7%
Status: COMPLETED
Conditions: Neutropenia
Interventions: DRUG: chlorhexidine 0.12%/Ethyl alcohol 7%|DRUG: Ethyl Alcohol 7%|DRUG: Chlorhexidine 2%/Ethyl alcohol 7%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients
Status: COMPLETED
Conditions: Hypertension|Brain Tumor|Epilepsy
Interventions: DRUG: Clevidipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-Arterial Neuroprotective Agents and Cold Saline in Ischemic Stroke Intervention
Status: RECRUITING
Conditions: Stroke, Ischemic
Interventions: DRUG: Intra-arterial cold saline, minocycline, and magnesium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapies on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity Which Protect Islet β Cell
Status: UNKNOWN
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: DPP4|DRUG: Insulin|DRUG: SU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MITAORTA - Role of Mitochondrial Dynamic in Aneurysm and Dissection of Ascending Thoracic Aorta
Status: ACTIVE_NOT_RECRUITING
Conditions: Aortic Aneurysm and Dissection
Interventions: OTHER: Mitochondrial dynamic analysis in the aorta samples and metabolomic profiling in the aortic diseases
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: IMVAMUNE®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SPI-directed Analgesia for Vitreoretinal Surgeries
Status: COMPLETED
Conditions: Vitreoretinal Surgeries|Postoperative Nausea and Vomiting|Postoperative Pain
Interventions: DRUG: Metamizol|DRUG: Acetaminophen|DRUG: 0,5 % bupivacaine with of 2% lidocaine|DRUG: Proxymetacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Mirtazapine to Reduce Methamphetamine Use Among MSM With High-risk HIV Behaviors
Status: COMPLETED
Conditions: Substance Abuse|HIV Infections
Interventions: DRUG: mirtazapine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Biomarker Study for Predicting the Efficacy of Neoadjuvant Sintilimab Plus SOX for Gastric Adenocarcinoma.
Status: NOT_YET_RECRUITING
Conditions: Gastric Cancer
Interventions: DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Open, Single-arm, Multi Centre Pilot Investigation to Evaluate the Debriding Effect of ChloraSolv® on Chronic Wounds
Status: COMPLETED
Conditions: Chronic Ulcer at Lower Leg
Interventions: DEVICE: ChloraSolv
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Identifying Characteristic Signature of Attention Deficit / Hyperactivity Disorder (ADHD) and Ritalin Treatment
Status: UNKNOWN
Conditions: "Attention Deficit Hyperactivity Disorder"
Interventions: DRUG: Ritalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Reversibility of Bronchial Obstruction in Children Born Preterm
Status: RECRUITING
Conditions: Bronchopulmonary Dysplasia|Chronic Lung Disease of Prematurity|Chronic Lung Disease of Newborn|Preterm Birth Complication|Bronchial Hyperreactivity|Bronchial Obstruction|Reversible Dilatation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Using the LMC Diabetes Registry to Learn More About Chronic Kidney Disease (CKD) in Canadian Patients With Type 2 Diabetes (T2D)
Status: COMPLETED
Conditions: Chronic Kidney Disease in Type 2 Diabetes
Interventions: DRUG: The physician's prescription in routine clinical practice
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose Response Oxidation of a Sweet-corn Derived Sugar (PhytoSpherix) During Exercise in Endurance Trained Athletes
Status: UNKNOWN
Conditions: Hypoglycemia
Interventions: DIETARY_SUPPLEMENT: Use of PhytoSpherix at 0 g/min|DIETARY_SUPPLEMENT: Use of PhytoSpherix at 1 g/min|DIETARY_SUPPLEMENT: Use of PhytoSpherix at 1.5 g/min|DIETARY_SUPPLEMENT: Use of PhytoSpherix at 2 g/min|BEHAVIORAL: Cycling exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Everolimus Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Everolimus Study.
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Everolimus|DRUG: Sandostatin LAR Depot
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare and Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of UI059 and UIC202201
Status: NOT_YET_RECRUITING
Conditions: Gastro-Intestinal Disorder
Interventions: DRUG: UI059|DRUG: UIC202201
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vit K Antagonists for Acute DVT and PE
Status: COMPLETED
Conditions: Post Thrombotic Syndrome|Deep Vein Thrombosis|Chronic Thromboembolic Pulmonary Hypertension
Interventions: OTHER: no intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison Between Conventional and Digital Workflow in Dental Prosthesis
Status: COMPLETED
Conditions: Dental Prosthesis Complication
Interventions: PROCEDURE: Fully digital workflow of prosthetic fixed dental crown|PROCEDURE: Combined digital and conventional workflows of prosthetic fixed dental crown|PROCEDURE: Fully conventional workflow of prosthetic fixed dental crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Atezolizumab in Combination With Carboplatin Plus (+) Nab-Paclitaxel Compared With Carboplatin+Nab-Paclitaxel in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Squamous Non-Small Cell Lung
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody|DRUG: Carboplatin|DRUG: Nab-Paclitaxel|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Diindolylmethane (DIM) for the Treatment of Cervical Dysplasia
Status: COMPLETED
Conditions: Cervical Dysplasia
Interventions: DRUG: di indolylmethane (DIM)|DIETARY_SUPPLEMENT: Red rice bran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation.
Status: COMPLETED
Conditions: Inner Ear Disease|Equilibrium; Disorder, Labyrinth|Spatial Navigation
Interventions: OTHER: Vestibular reeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Prospective Observational Trial to Determine Cardiovascular Diseases in HIV-infected Patients
Status: COMPLETED
Conditions: HIV-infection|Coronary Heart Disease|Myocardial Infarction|HIV-encephalopathy|Heart Failure|Aging
Interventions: OTHER: Comprehensive non invasive cardiovascular examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Patient Blood Management In CARdiac sUrgical patientS
Status: COMPLETED
Conditions: Anemia|Blood Loss Anemia|Iron-deficiency|Iron Deficiency Anemia|Iron Deficiency Anemia Treatment|Erythropoiesis Abnormal
Interventions: DRUG: Ferric carboxymaltose|DRUG: B vitamin|DRUG: Folic acid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of an Additional Hydrophobic Adhesive Layer Application on the Class V Composite Restorations
Status: COMPLETED
Conditions: Non Carious Cervical Lesion
Interventions: OTHER: Clearfil Majesty ES-2 Resin Composit Application to Non-carious Cervical Lesions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Intrauterine Growth Restriction|Preeclampsia|Sickle Cell Disease|Pregnancy Complications
Interventions: DRUG: Low-dose aspirin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Safety and Tolerability of Niraparib With Everolimus in Advanced Gynecologic Malignancies and Breast
Status: COMPLETED
Conditions: Breast Cancer|Ovarian Cancer
Interventions: DRUG: niraparib|DRUG: everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Burch Colposuspension Versus Modified Burch Colposuspension
Status: RECRUITING
Conditions: Stress Urinary Incontinence|Burch Colposuspention
Interventions: PROCEDURE: Laparoscopic Burch colposuspension|PROCEDURE: Modefied Burch (TOT - like)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes
Status: RECRUITING
Conditions: Type 2 Diabetes
Interventions: OTHER: Maximal ATP Production (ATPmax)|OTHER: Exercise Testing (VO2max)|PROCEDURE: Muscle Biopsy|PROCEDURE: Adipose Tissue Biopsy|OTHER: Hyperinsulinemic euglycemic clamp|OTHER: PET imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Technosphere Insulin Inhalation Powder|DRUG: Rapid Acting Analog
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Repeated Transforaminal Anesthetic Injections With or Without Glucocorticoid in Patients With Cervical Radiculopathy
Status: UNKNOWN
Conditions: Neck Pain|Radiculopathy, Cervical|Cervical Foraminal Stenosis|Cervical Disc Disease
Interventions: PROCEDURE: Glucocorticoid Injections|PROCEDURE: Anesthetic Injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of KHK4951 in Healthy Volunteers and Patients With Wet Age-Related Macular Degeneration
Status: TERMINATED
Conditions: Healthy Volunteers|Wet Age-related Macular Degeneration
Interventions: DRUG: Placebo|DRUG: KHK4951
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Abuse Liability Potential of ALKS 5461 in Healthy, Non-Dependent, Recreational Opioid Users
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALKS 5461|DRUG: Buprenorphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of EMD 72000 in Combination With ECX (Epirubicin, Cisplatin and Capecitabine) in Oesophagogastric Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: EMD 72000 (matuzumab) + ECX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Veltuzumab and 90Y-Epratuzumab in Relapsed/Refractory, Aggressive NHL
Status: WITHDRAWN
Conditions: Non Hodgkin's Lymphoma|NHL|Aggressive NHL|Diffuse Large B-cell Lymphoma
Interventions: DRUG: Veltuzumab and 90Y-Epratuzumab Tetraxetan|DRUG: 90Y-epratuzumab tetraxetan|DRUG: veltuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Detrol LA on Overactive Bladder Symptoms, Sexual Quality of Life and Sexual Function in Women
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DRUG: Tolterodine ER 4mg QD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Problem-Solving Therapy for Depressive Symptoms and Quality of Life in Stroke Survivor-Caregiver Dyads
Status: COMPLETED
Conditions: Stroke|Quality of Life|Depression
Interventions: BEHAVIORAL: Problem-Solving Therapy|OTHER: Stroke-Related Health Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Immune Disorder HSCT Protocol
Status: RECRUITING
Conditions: Immune Deficiency Disorders|Severe Combined Immunodeficiency|Chronic Granulomatous Disease|X-linked Agammaglobulinemia|Wiskott-Aldrich Syndrome|Hyper-IgM|DiGeorge Syndrome|Chediak-Higashi Syndrome|Common Variable Immune Deficiency|Immune Dysregulatory Disorders|Hemophagocytic Lymphohistiocytosis|IPEX|Autoimmune Lymphoproliferative Syndrome|X-linked Lymphoproliferative Syndrome
Interventions: DRUG: Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Pedometer-based Unsupervised Exercise Program Upon Lifestyle Physical Activity of Asthmatic Adults
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Pedometer-based physical activity prescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intravesical Gentamicin to Prevent Recurrent UTI
Status: NOT_YET_RECRUITING
Conditions: Recurrent Uti
Interventions: DRUG: Gentamicin|DRUG: Nitrofurantoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of AMG 714 for Vitiligo
Status: ACTIVE_NOT_RECRUITING
Conditions: Vitiligo
Interventions: BIOLOGICAL: AMG 714|BIOLOGICAL: Placebo|PROCEDURE: nbUVB phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Greek Study for Endovascular Repair of Ruptured Abdominal Aortic Aneuryms
Status: UNKNOWN
Conditions: Rupture, Aortic|Aneurysm, Abdominal Aortic|Aneurysm, Ruptured
Interventions: DEVICE: Endovascular repair of ruptured abdominal aortic aneurysm (EVAR) with Medtronic Endurant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy, Safety and Tolerability of Multiple Doses of Valsartan in Children With Hypertension With or Without CKD
Status: COMPLETED
Conditions: Pediatric Hypertension With or Without CKD
Interventions: DRUG: VAL489|DRUG: VAL489 matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study Evaluating the Safety of Stereotactic Central Ablative Radiation Therapy (SCART) for Bulky Metastatic or Recurrent Cancer
Status: UNKNOWN
Conditions: Malignant Neoplasms
Interventions: RADIATION: SCART radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Tapping in the Venous Dilatation for Peripheral IV Access
Status: COMPLETED
Conditions: Catheterization, Peripheral|Venous Dilatation
Interventions: DEVICE: Tourniquet|DEVICE: Manual Tapping|DEVICE: Device tapping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Device-guided Breathing for Shortness of Breath in COPD
Status: COMPLETED
Conditions: COPD|Dyspnea|Hyperinflation
Interventions: BEHAVIORAL: Twice daily practice of device-guided slow breathing.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Performance and Hemocompatibility of Dialyzers Applied During Post-dilution Online Hemodiafiltration
Status: COMPLETED
Conditions: Renal Failure|End Stage Renal Disease
Interventions: DEVICE: Dialyser
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Role of Intravitreal Tissue Plasminogen Activator in Treatment of Refractory Diabetic Macular Edema
Status: TERMINATED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Tissue Plasminogen Activator,bevacizumab ,follow up
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Alisertib in Treating Patients With Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma
Status: COMPLETED
Conditions: Adult Nasal Type Extranodal NK/T-Cell Lymphoma|Anaplastic Large Cell Lymphoma|Angioimmunoblastic T-Cell Lymphoma|Hepatosplenic T-Cell Lymphoma|Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma|Recurrent Adult Non-Hodgkin Lymphoma|Recurrent Adult T-Cell Leukemia/Lymphoma
Interventions: DRUG: Alisertib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Exercise Training for Weight Loss
Status: COMPLETED
Conditions: Circuit-based High Intensity Interval Training|Body Composition|Resting Metabolic Rate|Habitual Physical Activity|Performance
Interventions: BEHAVIORAL: DoIT workout|BEHAVIORAL: DoIT workout - Detraining|BEHAVIORAL: Control - No training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Fluoride Varnish, Ozone, Octenidin and WSLs in Orthodontic Patients
Status: COMPLETED
Conditions: White Spot Lesion of Tooth
Interventions: PROCEDURE: PMTC|PROCEDURE: fluoride varnish|PROCEDURE: gaseous ozone therapy|PROCEDURE: domestic octenidin mouth rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of a Milk-based Nutrient-rich Bar on Nutritional Status and Cognitive Performance of School Children in Vietnam
Status: COMPLETED
Conditions: Cognitive Performance
Interventions: DIETARY_SUPPLEMENT: food bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: This Study Aims to Find the Best Dose of BI 907828 (Brigimadlin) in Patients With Different Types of Advanced Cancer (Solid Tumors)
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: BI 907828
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Pre-operative Use of Finasteride Versus Cyproterone Acetate on Blood Loss With Transurethral Resection of Prostate
Status: COMPLETED
Conditions: Prostate Hyperplasia
Interventions: DRUG: cyproterone acetate|DRUG: finasteride|DRUG: no treatment received
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Doxorubicin in cTACE of Liver Cancer
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: whole liver lobe cTACE doxorubicin|DRUG: superselective cTACE doxorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: POWER (Pulse Width Optimized Waveform Evaluation Trial)
Status: COMPLETED
Conditions: Sudden Cardiac Death
Interventions: DEVICE: Implantable Cardioverter Defibrillator (ICD), Cardiac Resynchronization Therapy (CRT-D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: DRUG: Aceclofenac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Single-probe Microwave Ablation (MWA) of Metastatic Liver Cancer
Status: COMPLETED
Conditions: Liver Neoplasms
Interventions: DEVICE: Microwave ablation|DEVICE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing The Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Ibrutinib|BIOLOGICAL: Obinutuzumab|OTHER: Observation|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Amount of Medications That May be Removed From the Body During Plasmapheresis
Status: WITHDRAWN
Conditions: Kidney Transplantation|Plasmapheresis
Interventions: DRUG: tacrolimus|DRUG: mycophenolate mofetil|DRUG: daclizumab|DRUG: intravenous immune globulin|PROCEDURE: plasmapheresis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of rhBSSL With Placebo When Added to Infant Formula or Pasteurized Breast Milk During 4 Weeks of Treatment in Preterm Infants
Status: TERMINATED
Conditions: Prevention of Growth Restriction
Interventions: DRUG: rhBSSL (recombinant human bile-salt-stimulated lipase)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Buprenorphine to Paracervical Block for Pain Control During Osmotic Dilator Insertion
Status: COMPLETED
Conditions: Procedural Pain|Buprenorphine|Adjuvants, Anesthesia|Dilation and Evacuation|Analgesics
Interventions: DRUG: Buprenorphine 0.15 MG|DRUG: Lidocaine 1% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Adverse Events and Effectiveness of Rapid Acoustic Pulse (RAP) Device for the Appearance of Cellulite in Adult Participants
Status: RECRUITING
Conditions: Cellulite
Interventions: DEVICE: Rapid Acoustic Pulse
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Switch From Nucleotide to Peginterferon Alfa-2a in CHB Patients Achieving HBeAg Loss and HBV DNA <200IU/ml
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Peginterferon alfa 2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Proof-of-Concept Study to Determine the Flow Changes When Stimulating Two Neural Targets for the Treatment of Obstructive Sleep Apnea
Status: ACTIVE_NOT_RECRUITING
Conditions: Sleep Apnea|Sleep Apnea, Obstructive|Sleep Disorder|Sleep Apnea Syndromes
Interventions: DEVICE: Hypoglossal nerve and/or Ansa Cervicalis stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Mindfulness and Acceptance Applied in Colleges Through Web-Based Guided Self-Help (Phase II)
Status: COMPLETED
Conditions: Mental Health
Interventions: BEHAVIORAL: ACT-CL Web-based guided self-help|BEHAVIORAL: Control Web-based guided self-help
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enhancing Electronic Health Systems to Decrease the Burden of Colon Cancer, Lung Cancer, Obesity, Vaccine-Preventable Illness, and LivER Cancer
Status: COMPLETED
Conditions: Colon Cancer|Lung Cancer|Tobacco Use Cessation|Obesity|Pneumonia, Bacterial|Shingles|Hepatitis C
Interventions: OTHER: Epic Healthy Planet Population Health Module
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION