pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Acute Blood Loss Anemia|Osteoarthritis, Knee
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess Rate of Onset of Bronchodilator Action in Severe Stable Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Aclidinium bromide|DRUG: Placebo Tiotropium|DRUG: Tiotropium|DRUG: Placebo LAS34273
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Performance of AclarusDx™, a Blood-Based Transcriptomic Test for AD, in US Patients Newly Referred to a Memory Center
Status: COMPLETED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment|Vascular Dementia|Fronto-temporal Dementia|Primary Progressive Aphasia|Parkinson' Disease Dementia|Mixed Dementia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Retention, Chewing Efficiency and Masticatory Performance of Partial Dentures Opposing Implant Retained Prosthesis.
Status: COMPLETED
Conditions: Implant Site Reaction|Implant Complication
Interventions: DEVICE: evaluation of retention of Versacryle and CAD/CAM partial dentures by force gauge|DEVICE: chewing efficiency by electromyograph(E.M.G)|OTHER: masticatory performance(questionnaire)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Low Dose Ticagrelor in Patients With Unstable Angina Pectoris After Coronary Stent Implantation
Status: UNKNOWN
Conditions: Unstable Angina Pectoris|Coronary Stent Implantation
Interventions: DRUG: Ticagrelor 90 mg|DRUG: Ticagrelor 45 mg|DRUG: Aspirin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Normal Single Ascending Dose and Crohn's Patient Multiple Ascending Dose
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: DRUG: ZP1848
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open-label, Dose-ranging Study in Adults and Pediatric Individuals ≥ 12 Years of Age to Assess the Safety, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of AZD7442, for Pre-exposure Prophylaxis of COVID-19
Status: TERMINATED
Conditions: Coronavirus Disease 2019 (COVID-19)
Interventions: BIOLOGICAL: AZD7442 (tixagevimab [AZD8895] + cilgavimab [AZD1061])|BIOLOGICAL: AZD7442 (tixagevimab [AZD8895] + cilgavimab [AZD1061])
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fluid Collections Management in Severe Acute Pancreatitis
Status: UNKNOWN
Conditions: Acute Pancreatitis|Acute Pancreatic Fluid Collection
Interventions: PROCEDURE: Aspiration|PROCEDURE: Catheter drainage|DRUG: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PENG vs. FIC Block for Hip Fracture ED Patients
Status: RECRUITING
Conditions: Pain|Hip Fracture
Interventions: PROCEDURE: Nerve Block using FIC Proceedure|PROCEDURE: Nerve Block using PENG Proceedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
Status: COMPLETED
Conditions: COVID -19|Respiratory Failure|Hypoxia
Interventions: DEVICE: Oxygen Hood
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Assessing Pharmacokinetics and Bioavailability of Three Novel Triazine Compounds
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: WR826647|DRUG: WR909388|DRUG: WR909390
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France
Status: COMPLETED
Conditions: Allergic Rhinitis Due to House Dust Mite|Allergic Asthma Due to Dermatophagoides Farinae|Allergic Asthma Due to Dermatophagoides Pteronyssinus
Interventions: DRUG: Tablet, Dispersible
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study in Asia of the Combination of TACE With Sorafenib in HCC Patients
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: doxorubicin|PROCEDURE: TACE (Transcatheter arterial chemoembolization)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Factors Affecting Sensory and Motor Learning
Status: RECRUITING
Conditions: Basic Science
Interventions: BEHAVIORAL: Explanatory diagram|BEHAVIORAL: Direct vision|BEHAVIORAL: Movement feedback, target hand|BEHAVIORAL: Movement feedback, pointing hand|BEHAVIORAL: No movement feedback|BEHAVIORAL: Attend to the targets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparator Study of the Effect of Glycopyrrolate and Glycopyrronium in Subjects With Axillary Hyperhidrosis
Status: COMPLETED
Conditions: Hyperhidrosis
Interventions: DRUG: Dose 1 of glycopyrrolate, 2.0% QD|DRUG: Dose 2 of glycopyrrolate, 3.0% QD|DRUG: Dose 1 of glycopyrronium, 2.5% QD|DRUG: Dose 2 of glycopyrronium, 3.75% QD|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Colchicine for Symptom and Inflammation in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: Colchicine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cavernous Tissue Preservation During Penile Prosthesis Implantation
Status: UNKNOWN
Conditions: Erectile Dysfunction
Interventions: PROCEDURE: Cavernous tissue sparing penile prosthesis implantation|PROCEDURE: Conventional penile prosthesis implantation|PROCEDURE: Intracavernosal injection of alprostadil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Phleum pratense grass pollen allergen extract|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety of Amifampridine Phosphate in Spinal Muscular Atrophy 3
Status: TERMINATED
Conditions: Spinal Muscular Atrophy Type 3
Interventions: DRUG: Amifampridine Phosphate 10 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Intended to Provide Input for Future Designs Using the PET Alpha Ring Detector
Status: COMPLETED
Conditions: Focus of Study is Imaging Performance With the New Technology Compared With the Currently Available Technology.
Interventions: DEVICE: Additional PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cinical Trial to Explore the Efficacy of Statin/Choline Fenofibrate Combination Therapy vs Statin Monotherapy in Patients With Inadequately Controlled TG Despite Receiving Statin Monotherapy
Status: UNKNOWN
Conditions: Dyslipidemias
Interventions: DRUG: Fenofibrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of EDG-5506 in Children With Duchenne Muscular Dystrophy (LYNX)
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: EDG-5506 Dose 1|DRUG: EDG-5506 Dose 2|DRUG: EDG-5506 Dose 3|DRUG: EDG-5506 Dose 4|DRUG: EDG-5506 Dose 5|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Non-thyroidal Illness Syndrome
Interventions: DRUG: liothyronine sodium|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Preoperative Embolization of the Inferior Mesenteric Artery in Colorectal Surgery
Status: RECRUITING
Conditions: Embolism Mesenteric
Interventions: PROCEDURE: Embolization of the inferior mesenteric artery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Suicide Risk Scale and Distress Intervention for the Patients With Chronic Medical Illness or Physical Disabilities
Status: COMPLETED
Conditions: Chronic Illnesses|Physical Disability
Interventions: OTHER: Distress intervention (CBT & Mindfulness-based program)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID)
Status: COMPLETED
Conditions: Gastric Ulcers|Duodenal Ulcers
Interventions: DRUG: TAK-438|DRUG: Placebo|DRUG: TAK-438|DRUG: Placebo|DRUG: Lansoprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines
Status: RECRUITING
Conditions: Chronic Low-back Pain|Mastectomy|Lumpectomy|Migraine
Interventions: DEVICE: JOGO Digital Therapeutics EMG Biofeedback for Lower Back Pain|DEVICE: JOGO Digital Therapeutics EMG Biofeedback for Persistent Post Mastectomy Pain|DEVICE: JOGO Digital Therapeutics EMG Biofeedback for Migraine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Route of Nutritional Support for Pancreatic Fistula
Status: UNKNOWN
Conditions: Closure of POPF After Pancreaticoduodenectomy
Interventions: OTHER: Jejunostomy tube feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neurochemical Mechanisms of the Awake vs. Anesthetized Brain
Status: UNKNOWN
Conditions: Anesthesia|Healthy
Interventions: DRUG: Dexmedetomidine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Comparison of Two Different Doses of Maternal B12 Supplementation in Improving Infant B12 Deficiency and Neurodevelopment
Status: COMPLETED
Conditions: Vitamin B 12 Deficiency
Interventions: DRUG: Vit B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Minimal Invasive Surgery in Total Hip Arthroplasty Patients; Strength, Functionality and Post Operative Complications
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: PROCEDURE: Direct lateral|PROCEDURE: minimal invasive|PROCEDURE: modified minimal invasive
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Comparison of BLI4700 Bowel Preparation Versus an FDA-approved Comparator in Adult Subjects Prior to Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy
Interventions: DRUG: BLI4700|DRUG: Magnesium bowel preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2a Topical Sildenafil Proof-of-Concept Study in Men With Mild to Moderate ED
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: Sildenafil Cream|DRUG: Placebo Cream|DEVICE: Penile Plethysmography (RigiScan)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: "Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)
Status: RECRUITING
Conditions: Degenerative Disc Disease|Chronic Low-back Pain
Interventions: DEVICE: PerQdisc Nucleus Replacement System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane
Status: COMPLETED
Conditions: Nociceptive Pain|Anesthesia
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Cetuximab - IRDye800 Intraoperative Fluorescence Imaging in Esophagectomy of Esophageal Cancer
Status: UNKNOWN
Conditions: Drug Safety ; Drug Specificity
Interventions: DRUG: Cetuximab-IRDye800
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pilot Project of Virologic and Immunologic Correlates of GALT Immune Reconstitution Following Raltegravir Therapy
Status: COMPLETED
Conditions: HIV Infections|AIDS
Interventions: DRUG: raltegravir|DRUG: efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis
Status: RECRUITING
Conditions: Sepsis
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Eslicarbazepine Acetate as Therapy in Diabetic Neuropathic Pain
Status: TERMINATED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: Eslicarbazepine acetate (BIA 2-093)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Nursing Support Program for Women in Surgical Menopause on Their Life Quality
Status: COMPLETED
Conditions: Nursing Caries|Surgical Menopause|Quality of Life
Interventions: OTHER: Nursing support program|OTHER: Routine nursing care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Short-Term Response of Thoracic Spine Manipulation With or Without Trigger Point Dry Needling for Mechanical Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Thoracic spinal manipulation|PROCEDURE: Trigger point dry needling|BEHAVIORAL: Cervical range of motion exercises|BEHAVIORAL: Posterior neck muscle activation exercise|PROCEDURE: Trigger point dry needling sham|DEVICE: Seirin J-type stainless steel needles, 0-2-0.3 x 40-50 mm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Topography Guided LASIK With WaveLight® EX500 to SMILE With Zeiss VisuMax
Status: TERMINATED
Conditions: Myopia|Astigmatism
Interventions: PROCEDURE: Topography Guided LASIK|PROCEDURE: Small Incision Lenticular Extraction|DEVICE: WaveLight EX500 Excimer Laser System|DEVICE: VisuMax Surgical Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Epidural Calcitonin in Lower Limb Amputation
Status: COMPLETED
Conditions: Amputation Stumps
Interventions: DRUG: Calcitonin|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Adding Vildagliptin vs Glimepiride to Metformin on Inflammation's Markers in Type-2 Diabetic Patients With CAD
Status: COMPLETED
Conditions: Coronary Artery Disease|Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin 50 mg Oral Tablet|DRUG: Metformin 1000 mg Oral Tablet|DRUG: Glimepiride upto 4 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LINEAR II - LME-159 Evaluation of a Multi-Electrode Linear Type Ablation Catheter
Status: COMPLETED
Conditions: Cavotricuspid Isthmus Dependent Right Atrial Flutter
Interventions: PROCEDURE: Endocardial Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nano Composites and Light Cure Composites - A Comparative Assessment of Bond Failure Rates
Status: ACTIVE_NOT_RECRUITING
Conditions: Nanotechnology, Dental Materials, Composites
Interventions: COMBINATION_PRODUCT: Nanohybrid Compisite Group (Filtek Z250)|COMBINATION_PRODUCT: Conventional Composite Group (Transbond XT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics, Tolerability and Safety of Two Different Dupilumab Drug Products in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Dupilumab (SAR231893)|DRUG: Dupilumab (SAR231893)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Peripheral Afferents in Modulating Post-stroke Central Pain
Status: RECRUITING
Conditions: Stroke
Interventions: DRUG: Lidocaine 20mg/ml|DRUG: Levobupivacaine Hydrochloride 1.25 MG/ML|DRUG: Sodium Chloride 0.9% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating Cerebral Oxygenation in the Newborn
Status: RECRUITING
Conditions: Hypoxic Ischemic Encephalopathy of Newborn|Neonatal Encephalopathy|Premature Infant Disease
Interventions: DEVICE: Near-infrared spectroscopy monitoring (Masimo O3 Regional Oximeter with Neonatal Sensor)|DEVICE: Near-infrared spectroscopy monitoring (Masimo O3 Regional Oximeter with Neonatal Sensor)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)
Status: NOT_YET_RECRUITING
Conditions: Hairy Cell Leukemia
Interventions: DRUG: Vemurafenib|DRUG: Obinutuzumab|DRUG: Cladribine|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Tramadol Hydrochloride-Paracetamol in Treatment of Moderate to Severe Acute Neck-Shoulder Pain and Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain|Shoulder Pain|Neck Pain
Interventions: DRUG: Tramadol HCl-Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia
Status: RECRUITING
Conditions: Acute Leukemias|Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia
Interventions: DRUG: Bleximenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bilateral Cervical Manipulation (C3/C4) on Thoracoabdominal Kinematics
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: OTHER: HVLA C3/C4 manipulation|OTHER: Sham technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis
Status: COMPLETED
Conditions: Acute Rhinosinusitis
Interventions: DRUG: BNO 1016|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Evaluation of Safety and Tolerance of Commercially Available Naltrexone Administered Daily - Assessment for CBRN Operations
Status: COMPLETED
Conditions: Opioid Intoxication
Interventions: DRUG: Naltrexone Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Assessment of Voriconazole Self Nano Emulsifying Drug Delivery System Intermediate Gel
Status: COMPLETED
Conditions: Tinea Versicolor
Interventions: DRUG: voriconazole gel once daily|DRUG: voriconazole gel twice daily|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mechanical Bowel Preparation Versus no Bowel Preparation for Esophageal Cancer Surgery
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: PROCEDURE: No MBP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Continuous Veno-venous Hemodiafiltration on Efficacy of Administration of Prophylactic Doses of Enoxaparin or Fondaparinux in Critically Ill Patients.
Status: UNKNOWN
Conditions: Assessment of Activity of Anti-Xa Factor in Patients Treated With Continuous Veno-venous Hemodiafiltration Receiving Anticoagulant Prophylaxis
Interventions: DIAGNOSTIC_TEST: Assessment the activity of anti-Xa factor.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TENS Unit for Analgesia During IUD Insertion
Status: NOT_YET_RECRUITING
Conditions: IUD|Analgesia|Patient Preference|Pain, Acute
Interventions: DEVICE: TENS (transcutaneous electrical nerve stimulation) unit|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of LP-003 in Patients With CSU Who Remain Symptomatic Despite Antihistamine (H1) Treatment
Status: RECRUITING
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: LP-003|BIOLOGICAL: Placebo|BIOLOGICAL: Omalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Y90 Radiation Segmentectomy vs SBRT for HCC
Status: TERMINATED
Conditions: Hepatocellular Carcinoma (HCC)
Interventions: RADIATION: Yttrium-90 Radiation Segmentectomy|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TocilizuMab discontinuAtion in GIant Cell Arteritis
Status: RECRUITING
Conditions: Giant Cell Arteritis
Interventions: DRUG: Tocilizumab treatment|OTHER: questionnaires|BIOLOGICAL: Blood samples|PROCEDURE: 18FDG PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 4D-contrast Enhanced PET-CT in Tumour Volume Definition
Status: UNKNOWN
Conditions: Lung Carcinoma|Lower Oesophageal Carcinoma|Pancreatic Carcinoma
Interventions: PROCEDURE: 4D PET-CT Scan|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: A Study in People With Idiopathic Pulmonary Fibrosis to Test Whether Pirfenidone Influences the Amount of BI 1015550 in the Blood
Status: NOT_YET_RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis
Interventions: DRUG: BI 1015550|DRUG: Pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of AbGn-168H in Patients With Steroid Refractory Acute Graft-vs-Host Disease After Donor Stem Cell Transplant
Status: TERMINATED
Conditions: Acute Graft Versus Host Disease
Interventions: BIOLOGICAL: AbGn-168H
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery
Status: UNKNOWN
Conditions: Bleeding and Cardiac Surgery|Allogeneic Blood Transfusion|Aortic Valve Replacement|Coronary Artery Bypass Graft Surgery
Interventions: DRUG: aprotinin or tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Study of TAK-919 in Healthy Japanese Adults (COVID-19)
Status: COMPLETED
Conditions: Coronavirus Disease (COVID-19)
Interventions: BIOLOGICAL: TAK-919|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: I-STAND R21: Reducing Sedentary Time in Older Adults
Status: COMPLETED
Conditions: Obesity|Sedentary Lifestyle
Interventions: BEHAVIORAL: I-STAND|OTHER: Healthy Living
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Leuprolide Acetate 22.5 mg Depot in Treatment of Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Leuprolide acetate 22.5 mg depot, GP-Pharm SA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Phytonadione to Reduce International Normalized Ratio (INR) Variability in Patients on Long-term Warfarin Therapy
Status: COMPLETED
Conditions: Coagulation Delay
Interventions: DIETARY_SUPPLEMENT: phytonadione
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Coping Strategies and Responsiveness to a Brief Online Intervention During COVID-19 Pandemic
Status: COMPLETED
Conditions: Behavior, Social|Autonomic Imbalance
Interventions: OTHER: Deep Breathing training|OTHER: Compassion focused intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of OSSIX-Plus Resorbable Collagen Membranes for Alveolar Ridge Preservation Following Exodontia
Status: COMPLETED
Conditions: Alveolar Bone Loss|Loss of Teeth Due to Extraction|Edentulous Alveolar Ridge
Interventions: DEVICE: OSSIX-Plus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of HemoStyp as an Adjunct for Management of Secondary Hemostasis in the Operative Setting
Status: COMPLETED
Conditions: Hemostasis|Bleeding
Interventions: DEVICE: HemoStyp|DEVICE: Surgicel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Genistein and Endometrial Hyperplasia
Status: COMPLETED
Conditions: Endometrial Hyperplasia
Interventions: DIETARY_SUPPLEMENT: Genivis|DRUG: Norethisterone Acetate|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI, and AD Subjects
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: florbetapir F 18|DRUG: Flortaucipir F18|PROCEDURE: Brain PET Scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects of Isoinertial Training on Rotator Cuff Tendinopathy
Status: UNKNOWN
Conditions: Rotator Cuff Tendinopathy
Interventions: OTHER: Isoinertial + eccentric exercise|OTHER: Eccentric exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Mechanical Ventilation and Risk of Postoperative Complications in Abdominal Surgery
Status: COMPLETED
Conditions: Ventilator-Induced Lung Injury|Mechanical Ventilation Complication|Postoperative Complications
Interventions: PROCEDURE: protective ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Z-plasty and Heineke-Mikulicz Scrotoplasty in the Management of Penoscrotal Web
Status: COMPLETED
Conditions: Urologic Diseases
Interventions: PROCEDURE: Z-scrotoplasty|PROCEDURE: Heineke-Mikulicz scrotoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-term Evaluation Protocol (12 Months Postoperative) of Total Knee Prostheses Anatomic With Resurfaced Patella Versus Non-resurfaced Patella in Patients Requiring Total Knee Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty
Interventions: OTHER: Patellar resurfacing|OTHER: Patellar non-resurfacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Exercise in Patients With Advanced Non-small Cell Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Lung Carcinoma|First Line Treatment|Second Line Treatment|NSCLC Stage IV|NSCLC Stage IIIB|Palliative Treatment|NSCLC Stage IIIC
Interventions: BEHAVIORAL: Exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Hematopoyetic Response of Anemic Patients With Hematologic Malignancies Treated With Erythropoietin B
Status: TERMINATED
Conditions: Anemia
Interventions: DRUG: Epoetin Beta
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Trabecular Metal™ Revision Hip Cup Using Bone Mineral Density (DEXA)
Status: COMPLETED
Conditions: Revision, Joint
Interventions: DEVICE: Trabecular Metal Revision Cup|DEVICE: Trabecular Metal Modular Cup
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-2)
Status: NOT_YET_RECRUITING
Conditions: Decompensated Cirrhosis
Interventions: BIOLOGICAL: UC-MSCs|BIOLOGICAL: Placebo(solution without UC-MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Bone Mineral Density Changes Using Two Tibial Base Plate Designs in Primary Total Knee Arthroplasty in Young Patient
Status: UNKNOWN
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Primary TKA with cemented modular metal-backed tibial implant|DEVICE: Primary TKA with uncemented trabecular metal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risedronate to Prevent Skeletal Related Events in Patients With Metastatic Prostate Cancer Commencing Hormonal Therapy
Status: TERMINATED
Conditions: Metastatic Prostate Cancer
Interventions: DRUG: Risedronate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Telitacicept in Generalized Myasthenia Gravis
Status: RECRUITING
Conditions: Myasthenia Gravis, Generalized
Interventions: BIOLOGICAL: Telitacicept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CTA Expression/Methylation and Response to Pembrolizumab of NSCLC Patients
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: OTHER: PD-L1 positive vs PD-L1 negative NSCLC patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BinaxNow COVID-19 IgG Rapid Test Device and Antibody Self Test
Status: COMPLETED
Conditions: COVID-19 Respiratory Infection
Interventions: DIAGNOSTIC_TEST: The BinaxNOW™ Antibody Tests measure IgG antibodies against SARS-CoV-2.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block
Status: RECRUITING
Conditions: Analgesia
Interventions: DRUG: Dexmedetomidine Hydrochloride|DRUG: Dexamethasone Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)
Status: COMPLETED
Conditions: HIV-Associated Lipodystrophy Syndrome|Cardiovascular Disease
Interventions: DRUG: Lamivudine|DRUG: Stavudine|DRUG: Didanosine|DRUG: Zidovudine|DRUG: Tenofovir|DRUG: Abacavir|DRUG: Efavirenz (EFV)|DRUG: Nevirapine|DRUG: Indinavir|DRUG: Saquinavir|DRUG: Amprenavir|DRUG: Ritonavir|DRUG: Nelfinavir|DRUG: Tipranavir|DRUG: enfuvirtide (T20)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy of Roflumilast and Pioglitazone in Treating Adults With Nonalcoholic SteatoHepatitis
Status: TERMINATED
Conditions: Nonalcoholic Steatohapatitis
Interventions: DRUG: Roflumilast|DRUG: Pioglitazone|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Status: NOT_YET_RECRUITING
Conditions: Glioblastoma|Recurrent Glioblastoma|Brain Tumor
Interventions: DRUG: Troriluzole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rTMS on Diabetic Peripheral Neuropathic Pain
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathic Pain
Interventions: DEVICE: repetitive transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Value of SGLT2 Inhibitor (Dapagliflozin) as an Added Therapy in Diabetic Patients With Heart Failure With Reduced Ejection Fraction; Randomized Controlled Clinical Trial
Status: UNKNOWN
Conditions: Heart Failure With Reduced Ejection Fraction (HFrEF)|Diabete Type 2|Cardiomyopathies
Interventions: DRUG: Dapagliflozin 10 MG|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Zinc, Mental Health, and School Performance in Guatemalan Schoolchildren
Status: COMPLETED
Conditions: Depression|Anxiety
Interventions: DIETARY_SUPPLEMENT: 10 mg zinc oxide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Garlic With Lime Juice and Chlorhexidine Mouthwash
Status: UNKNOWN
Conditions: Gingival Bleeding
Interventions: DRUG: garlic with lime mouth wash|DRUG: chlorhexidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oropharyngeal Exercises and Post-Stroke Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Apnea|Sleep Apnea Syndromes|Sleep Apnea, Obstructive|Stroke|Transient Ischemic Attack
Interventions: BEHAVIORAL: Oropharyngeal exercises|BEHAVIORAL: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial on the Effects of Progestin-based Contraception in the Genital Tract of HIV-infected and Uninfected Women
Status: COMPLETED
Conditions: HIV|Contraception
Interventions: DRUG: Depo-Medroxyprogesterone Acetate|DRUG: Progestin Contraceptive (Jadelle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of Oral AMN107 in Adults With Chronic Myelogenous Leukemia Resistant and/or Intolerant to Imatinib Mesylate Therapy
Status: COMPLETED
Conditions: Leukemia, Myeloid, Chronic
Interventions: DRUG: AMN107
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
Status: RECRUITING
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Keto-like supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of RYZ101 in Combination With SoC in Subjects With SSTR+ ES-SCLC
Status: RECRUITING
Conditions: SCLC,Extensive Stage
Interventions: DRUG: RYZ101 Dose Level 1|DRUG: RYZ101 Dose Level 2|DRUG: RYZ101 Dose Level 3|DRUG: RYZ101 Dose Level -1|DRUG: Atezolizumab|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of n-3 LCPUFAs in Patients With Colorectal Cancer
Status: COMPLETED
Conditions: Cancer Cachexia|Side Effects|Quality of Life
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Acupuncture Treatment for Patients Who Develop Arrhythmias in the Post-Operative Cardio-Thoracic Setting
Status: COMPLETED
Conditions: Post-Operative Atrial Fibrillation|Acupuncture Therapy
Interventions: PROCEDURE: Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Administration of Levosimendan in Patients Undergoing Coronary Surgery
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: Levosimendan infusion|DRUG: Placebo infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy Plus Celecoxib, Fluorouracil, and Cisplatin in Patients With Locally Advanced Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: DRUG: celecoxib|DRUG: cisplatin|DRUG: fluorouracil|RADIATION: brachytherapy|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tariquidar and Docetaxel to Treat Patients With Lung, Ovarian, Renal and Cervical Cancer
Status: COMPLETED
Conditions: Lung Neoplasms|Ovarian Neoplasms|Cervix Neoplasms|Renal Neoplasms
Interventions: DRUG: docetaxel|DRUG: tariquidar|OTHER: 99mTc-sestamibi imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The HOMBRE Trial: Comparing Two Innovative Approaches to Reduce Chronic Disease Risk Among Latino Men
Status: COMPLETED
Conditions: Obesity|Metabolic Syndrome|Lifestyle Intervention|Pre Diabetes
Interventions: BEHAVIORAL: Minimal intensity intervention|BEHAVIORAL: HOMBRE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Safety and Efficacy Study for Epoetin Alfa in Pre-dialysis Subjects.
Status: COMPLETED
Conditions: Anemia|Kidney Failure|Left Ventricular Hypertrophy
Interventions: DRUG: epoetin alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Preoperative Stereotactic Body Radiotherapy (SBRT) Followed by Hepatectomy for Centrally Located Hepatocellular Carcinoma: a Prospective, Single-center, Phase I Study
Status: UNKNOWN
Conditions: Centrally Located Hepatocellular Carcinoma|Stereotactic Body Radiotherapy|Hepatectomy
Interventions: RADIATION: Neoadjuvant stereotactic body radiation therapy (Multiple ascending dose) followed by hepatectomy for centrally located hepatocellular carcinoma.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy Combined With Radiotherapy vs Chemotherapy Alone for Distant Metastatic Nasopharyngeal Carcinoma
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Loco-regional Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Recombinant Coagulation Factor IX With Recombinant Albumin (rIX-FP) in Severe Hemophilia B Patients
Status: UNKNOWN
Conditions: Hemophilia
Interventions: DRUG: Albutrepenonacog Alfa 1 UNT [IDELVION]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load
Status: COMPLETED
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: Exjade
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Whole Body Electromyostimulation and/or Protein Supplementation on Sarcopenic Obesity in 70+
Status: COMPLETED
Conditions: Sarcopenic Obesity
Interventions: OTHER: Whole body Electromyostimulation (exercise)|DIETARY_SUPPLEMENT: Protein
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DDI Study of BMS-663068 With Etravirine (ETR) and/or Darunavir (DVR) + Ritonavir (RTV)
Status: COMPLETED
Conditions: Infection, Human Immunodeficiency Virus
Interventions: DRUG: BMS-663068|DRUG: Darunavir (DRV)|DRUG: Ritonavir (RTV)|DRUG: Etravirine (ETR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK8266 in Hypertensive Men (MK-8266-002)
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: MK-8226 BID, 1 mg|DRUG: MK-8266 BID, 1.8 mg|DRUG: MK-8266 TID, 1.8 mg|DRUG: MK-8266 TID, 2.4 mg|DRUG: MK-8266 TID, 2.4 mg|DRUG: Placebo BID (Panel A)|DRUG: Placebo BID (Panel B)|DRUG: Placebo TID (Panel C)|DRUG: Placebo TID (Panel D)|DRUG: Placebo TID (Panel E)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of Olpasiran on QT/QTc Intervals in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Basic Science
Interventions: OTHER: Placebo|DRUG: Olpasiran|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Assessment of AFP and PIVKA-II as Prognostic Indicators in Liver Transplantation for Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Liver Transplantation|Hepatocellular Carcinoma|Alpha-Fetoprotein|Protein Induced by Vitamin K Absence or Antagonist-II
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p