pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: TEMCAP in Grade 3 and Low Ki-67 Gastroenteropancreatic Neuroendocrine Tumors
Status: COMPLETED
Conditions: Neuroendocrine Tumors|Neuroendocrine Carcinoma|Temozolomide|Capecitabine
Interventions: DRUG: TEMCAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Diagnostic to Identify Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency in Brazil
Status: COMPLETED
Conditions: G6PD Deficiency
Interventions: DIAGNOSTIC_TEST: SD Biosensor STANDARD G6PD Test|DIAGNOSTIC_TEST: Pointe Scientific Test Kit|DIAGNOSTIC_TEST: HemoCue System|DIAGNOSTIC_TEST: Complete blood count (CBC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluate the Efficacy and Safety of Uthever NMN(Nicotinamide Mononucleotide, a Form of Vitamin B3)
Status: COMPLETED
Conditions: Aging
Interventions: OTHER: NMN|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Antigen Specific Immunotherapy in Patients With Advanced Renal Cell Carcinoma Using Tumor Associated Peptides
Status: UNKNOWN
Conditions: Renal Cell Cancer|Advanced Renal Cell Cancer
Interventions: BIOLOGICAL: peptide vaccine|DRUG: Granulocyte Macrophage Colony Stimulating Factor|DRUG: Montanide ISA-51
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of TIL Following CCRT in Patients With Locoregionally Advanced NPC
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Cisplatin+TIL|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Method Study: Bilateral TAP Block With 24 Hours Infusion
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: Infusion of ropivacaine|PROCEDURE: Infusion of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of Enteric-coated Mycophenolate Sodium in Combination With Full Dose or Reduced Dose Cyclosporine Microemulsion in Patients With de Novo Kidney Transplants
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-Coated Mycophenolate Sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants
Status: COMPLETED
Conditions: Vaping|Nicotine Absorption
Interventions: OTHER: E-cigarette|OTHER: P4M3-1.7%|OTHER: P4M3-1.7%LA|OTHER: P4M3-3%LA|OTHER: P4M3-4%LA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET)
Status: NOT_YET_RECRUITING
Conditions: IVF|Frozen Embryo Transfer (FET)|Cardiovascular Adaption|Magnetic Resonance Imaging (MRI)|Preeclampsia
Interventions: OTHER: magnetic resonance imaging (MRI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Immunogenicity and Safety Study of SCB-2023 Vaccine as a Booster in Adults
Status: WITHDRAWN
Conditions: COVID-19
Interventions: BIOLOGICAL: SCB-2023 vaccine (trivalent), a recombinant SARS-CoV-2 trimeric S-protein subunit vaccine for COVID-19; intramuscular injection|BIOLOGICAL: SCB-2019 (monovalent), a recombinant SARS-CoV-2 trimeric S-protein subunit vaccine for COVID-19; intramuscular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of DCR-AUD in Healthy Volunteers
Status: COMPLETED
Conditions: Alcohol Use Disorder (AUD)
Interventions: DRUG: DCR-AUD|DRUG: Placebo for DCR-AUD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Paliperidone Extended-Release (ER) Versus Risperidone for Neurocognitive Function in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Paliperidone ER|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery
Status: NOT_YET_RECRUITING
Conditions: Malignant Female Reproductive System Neoplasm
Interventions: DRUG: Hydromorphone|DRUG: Methadone|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of MCS-5 in Treating Male Oligoasthenospermia
Status: TERMINATED
Conditions: Male Oligoasthenospermia
Interventions: DRUG: MCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevention of Infections in Cardiac Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracic Surgery|Antibiotic Prophylaxis
Interventions: DRUG: Cefazolin|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Role of Magnesium in Pediatric Cochlear Implant
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Magnesium sulphate|OTHER: Na CL 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open-label, Phase I/II Study of Manganese Plus Radiotherapy in Patients With Metastatic Solid Tumors or Lymphoma
Status: UNKNOWN
Conditions: Solid Tumor|Lymphoma
Interventions: DRUG: Manganese Chloride|RADIATION: Radiotherapy|DRUG: Chemo-immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Fluids in Adults With Diabetic Ketoacidosis in the Emergency Department
Status: COMPLETED
Conditions: Diabetic Ketoacidosis
Interventions: OTHER: Ringer's lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rehabilitation for Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: BEHAVIORAL: COPD Wellness|BEHAVIORAL: Health Advocate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Nitrous Oxide as Treatment for Major Depression - a Pilot Study
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: DRUG: Nitrous Oxide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Use of Diaries in Intensive Care Units
Status: RECRUITING
Conditions: Diary (Blank Journal)|Intensive Care Unit|Patient|Family|PICS|Stress|Anxiety|Depression|Quality of Life
Interventions: OTHER: use of diary
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D Levels in Non-immediate Drug Hypersensitivity Case-control Study
Status: COMPLETED
Conditions: Stevens-Johnson Syndrome|Drug Reaction With Eosinophilia and Systemic Symptom|Maculopapular Exanthem|Vitamin D Deficiency|Drug-Induced Rash
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy Trial of Warrior Check-Up
Status: COMPLETED
Conditions: Alcohol Abuse|Alcohol Dependence|Substance Abuse|Substance Dependence
Interventions: BEHAVIORAL: Motivational Enhancement Therapy|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: dTMS as a Treatment for Patients With Fibromyalgia
Status: UNKNOWN
Conditions: Studying Efficacy of dTMS in FM
Interventions: DEVICE: prefrontal deep rTMS of H1 Coil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phototherapy for the Management of Oral Ulcers in Bone Marrow Recipients
Status: COMPLETED
Conditions: Oral Mucosal Ulceration|Oral Mucositis|Oral Lesion
Interventions: DEVICE: phototherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Valsartan/Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: K-SAB Trial - Sotorasib Followed by SBRT to 1-3 Lesions in Advanced NSCLC With KRASG12C Mutation
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer Metastatic
Interventions: RADIATION: Stereotactic body radiation therapy (SBRT)|DRUG: Temporary Stopping
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Heredity and Phenotype Intervention (HAPI) Heart Study
Status: COMPLETED
Conditions: Cardiovascular Diseases
Interventions: OTHER: Aspirin|OTHER: Cold Pressor Test|OTHER: High Fat Meal|OTHER: Dietary Salt
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neoadjuvant and Adjuvant Nivolumab in HCC Patients Treated by Electroporation
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Nivolumab Injection [Opdivo]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: [18F]F-AraG/Total Body PET Imaging and Healthy Subjects and Lung Cancer Patients
Status: ENROLLING_BY_INVITATION
Conditions: Lung Cancer, Nonsmall Cell
Interventions: DRUG: [18F]F-AraG Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nerve Grafting With an Allograft During Radical Prostatectomy - Extended Follow-up in a Prospective Randomized Trial
Status: TERMINATED
Conditions: Erectile Dysfunction Following Radical Prostatectomy
Interventions: BIOLOGICAL: Radical prostatectomy with implantation of allograft|PROCEDURE: Radical prostatectomy without implantation of allograft
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pectoral Nerve Blockade in Mastectomy
Status: WITHDRAWN
Conditions: Postoperative Pain|Breast Cancer
Interventions: DRUG: Paravertebral nerve block: 4 mL ropivacaine 0.5% at each of six levels|DRUG: 10 cc of 0.375% ropivacaine pectoral nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality
Status: RECRUITING
Conditions: Severe Sepsis|Septic Shock|MODS
Interventions: DRUG: Ulinastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Methylene Blue for the Treatment of Septic Shock
Status: RECRUITING
Conditions: Septic Shock
Interventions: DRUG: Methylene Blue|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Belinostat in Combination With Bortezomib in Patients With Relapsed, Refractory Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: PXD101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The European Study of Altis Single Incision Sling System for Female Stress Urinary Incontinence
Status: COMPLETED
Conditions: Stress Urinary Incontinence
Interventions: DEVICE: Altis Single Incision Sling System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on Nol-Index Guided Remifentanil Analgesia
Status: COMPLETED
Conditions: Nociceptive Pain|Anesthesia|Opioid Use|Perioperative/Postoperative Complications
Interventions: DRUG: Dexmedetomidine|DRUG: sodium chloride|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: SWITCH ON: Analysing the Immunogenicity of Additional Booster Vaccinations in HCW
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid-19 Vaccination
Interventions: DRUG: Direct boost mRNA|DRUG: Direct boost adeno|DRUG: Post-poned boost mRNA|DRUG: Post-poned boost adeno
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study Of The Safety, Tolerability And Pharmacokinetics Of Single Doses Of PF-05180999 In Healthy Adults
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: PF-05180999|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bridging Study for Killed Oral Cholera Vaccine in Ethiopia
Status: COMPLETED
Conditions: Vibrio Cholerae|Cholera
Interventions: BIOLOGICAL: Killed Bivalent (O1 and O139) whole cell oral cholera vaccine|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Trial on the Effect of Optically Modified Fiber Mattress Covers on Sleep Disturbances in Patients With Chronic Back Pain
Status: COMPLETED
Conditions: Back Pain|Insomnia
Interventions: DEVICE: Active Mattress Cover|DEVICE: Placebo Mattress Cover
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Blood and Bone Marrow Samples in Patients With Chronic Myelogenous Leukemia Enrolled on a CALGB Clinical Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia
Interventions: GENETIC: DNA analysis|GENETIC: Southern blotting|GENETIC: cytogenetic analysis|GENETIC: polymerase chain reaction
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Effects of Radiofrequency in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: Single-session of Radiofrequency|DEVICE: Control Placebo single-session of Radiofrequency
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation
Status: COMPLETED
Conditions: Mitral Valve Insufficiency|Coronary Artery Disease
Interventions: PROCEDURE: Mitral Valve Repair with Annuloplasty|PROCEDURE: Mitral Valve Replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cranial Electric Stimulation to Modify Suicide Risk Factors in Psychiatric Inpatients.
Status: TERMINATED
Conditions: Suicide|Depression|Anxiety|Insomnia|Agitation
Interventions: DEVICE: Alpha-Stim®.|BEHAVIORAL: Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, The Pittsburgh Sleep Quality Index and agitated behavior Scale
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Obesity in Sleep Medicine - Focusing on OHS Phenotypes
Status: COMPLETED
Conditions: Obesity Hypoventilation Syndrome (OHS)
Interventions: DIAGNOSTIC_TEST: Sleep Study|DIAGNOSTIC_TEST: Pulmonary Function Test|DIAGNOSTIC_TEST: Hypercapnic ventilatory response|DIAGNOSTIC_TEST: Cardiopulmonary Exercise Test
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Assessment of the Effect of Atorvastatin on Prevention of CIN in Patients Undergoing Coronary Angiography
Status: UNKNOWN
Conditions: Contrast Induced Nephropathy
Interventions: DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis
Status: RECRUITING
Conditions: Crohn's Disease
Interventions: OTHER: side-to-side functional end anastomosis|OTHER: Kono-S analstomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Samarium 153 and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: DRUG: bortezomib|RADIATION: samarium Sm 153 lexidronam pentasodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Goal Directed Therapy Aiming to Optimise Oxygen Central Venous Saturation in Children Undergoing Cardiac Surgery
Status: RECRUITING
Conditions: Heart; Dysfunction Postoperative, Cardiac Surgery|C.Surgical Procedure; Cardiac
Interventions: OTHER: Continuous central venous oxygenation monitoring|OTHER: Standard protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Health Feedback System (DHFS) for Longitudinal Monitoring of ARVs Used in HIV Pre-exposure Prophylaxis (PrEP)
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Prevention
Interventions: DEVICE: Digital Health Feedback System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine
Status: COMPLETED
Conditions: Refractory Chronic Migraine
Interventions: DEVICE: Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Long Term Study of Lanthanum Carbonate in Patients Requiring Dialysis Who Have Ived Lanthanum Carbonate in Previous Studies Defined by the Protocol.
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Lanthanum carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Pain Modulation in GERD Patients Who Failed Standard Dose PPI
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DRUG: Rabeprazole 20mg, placebo dinner and bedtime|DRUG: Rabeprazole 20 mg two times, Placebo at bedtime|DRUG: Rabeprazole 20mg,placebo dinner ,Low dose Tricyclic Antidepressant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Bevacizumab and Ranibizumab on Ocular Pulse Amplitude in Neovascular Age Related Macular Degeneration (AMD)
Status: UNKNOWN
Conditions: Neovascular Age Related Macular Degeneration
Interventions: DEVICE: Pascal Dynamic Contour Tonometer|DRUG: Ranibizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Glimepiride 4 mg Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glimepiride 4 mg Tablets|DRUG: AMARYL® 4 mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Acute Myeloid Leukemia Treated With With NETrin Abs in Combination With [AZACITIDINE + VENETOCLAX]
Status: RECRUITING
Conditions: Acute Myeloid Leukemia Refractory
Interventions: DRUG: NP137|DRUG: Azacitidine Injection|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Study to Evaluate the Safety, PK, and PD of MEK Inhibitor GSK1120212 in Subjects With Relapsed or Refractory Leukemias
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: GSK1120212|DRUG: GSK1120212
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma
Status: NOT_YET_RECRUITING
Conditions: Brain Stem Glioma
Interventions: RADIATION: Radiation|DRUG: Atengenal|DRUG: Astugenal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multimodal Analgesia in Cardiac Surgery (Pilot Study)
Status: TERMINATED
Conditions: Heart Diseases
Interventions: DRUG: Lidocaine|DRUG: Unrestricted Fentanyl|DRUG: Ketamine|DRUG: Precedex|DRUG: Duramorph
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Oxiconazole Nitrate Solid Lipid Nanoparticles Loaded Gel
Status: COMPLETED
Conditions: Tinea
Interventions: DRUG: Oxiconazole Nitrate Cream 1%|DRUG: Oxiconazole nitrate SLNs loaded gel.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Freezie Remedy to Alleviate Morning Sickness
Status: TERMINATED
Conditions: Morning Sickness
Interventions: OTHER: Lillipops Iced Soothies (4 flavours)|OTHER: Mr. Freeze Freezies|OTHER: Lillipop Iced Soothies (Ginger flavour)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Tramadol Versus Intravenous Paracetamol in Patients With Dysmenorrhea
Status: COMPLETED
Conditions: Dysmenorrhea
Interventions: DRUG: tramadol|DRUG: paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Long-Term Safety, Tolerability and Efficacy of Dalfampridine.
Status: TERMINATED
Conditions: Post-ischemic Stroke
Interventions: DRUG: dalfampridine-ER 7.5 mg|DRUG: dalfampridine-ER 10 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bendamustine and Rituximab in Combination With Copanlisib for the Treatment of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: TERMINATED
Conditions: Lymphoid Leukemia|Non-Hodgkin's Lymphoma|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Interventions: DRUG: Copanlisib|BIOLOGICAL: Rituximab|DRUG: Bendamustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study to Compare IV CXA 101/Tazobactam and Metronidazole With Meropenem in Complicated Intraabdominal Infections
Status: COMPLETED
Conditions: Complicated Intra-abdominal Infection
Interventions: DRUG: CXA-101/ tazobactam and metronidazole|DRUG: meropenem plus saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Ezetimibe on Gallbladder Function
Status: WITHDRAWN
Conditions: Chronic Acalculous Cholecystitis
Interventions: DRUG: ezetimibe|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: tDCS and Female Urinary Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: PROCEDURE: Real transcranial direct current stimulation + therapeutic exercises for urinary incontinence|PROCEDURE: Sham transcranial direct current stimulation + therapeutic exercises for urinary incontinence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: γδT Cells Immunotherapy in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL)
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma|Relapsed or Refractory B Cell Non-Hodgkin's Lymphoma|Chronic Lymphoblastic Leukemia|Peripheral T Cell Lymphoma
Interventions: BIOLOGICAL: Autologous γδT cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fruquintinib Food Effect and Proton Pump Inhibitor Study
Status: COMPLETED
Conditions: Drug Interaction|Food-drug Interaction
Interventions: DRUG: fruquintinib with food/fruquintinib without food/fruquintinib with rabeprazole|DRUG: fruquintinib without food/fruquintinib with food/fruquintinib with rabeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ultrasound-guided Alveolar Recruitment in Laparoscopic Gynecological Surgery
Status: COMPLETED
Conditions: Pulmonary Atelectasis
Interventions: PROCEDURE: lung ultrasound-guided alveolar recruitment|PROCEDURE: conventional alveolar recruitment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase 1B Study Evaluating Alternative Routes of Administration of CMP-001 in Combination With Pembrolizumab in Participants With Advanced Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: CMP-001|DRUG: Pembrolizumab|DRUG: CMP-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Customized PRK With Mitomycin Versus Customized Lasik for Myopic Astigmatism
Status: COMPLETED
Conditions: Refractive Errors
Interventions: PROCEDURE: Prk with mitomycin vs Lasik
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: RIBS IV (Restenosis Intra-stent of Drug-eluting Stents: Paclitaxel-eluting Balloon vs Everolimus-eluting Stent)
Status: UNKNOWN
Conditions: In-stent Restenosis
Interventions: DEVICE: Coronary angioplasty using the paclitaxel-eluting balloon|DEVICE: Coronary angioplasty using the Everolimus-eluting stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PICSI RCT in Couples With a Previous Poor Fertilisation Cycle in IVF
Status: RECRUITING
Conditions: Infertility|IVF
Interventions: PROCEDURE: ICSI|PROCEDURE: PICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of a Wholegrain Diet on Body Composition and Energy Balance
Status: COMPLETED
Conditions: Overweight|Obesity|Pre-diabetic
Interventions: DIETARY_SUPPLEMENT: Whole grains
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: DMARDs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety and Pharmacokinetics of AZD6793 in Healthy Japanese and Chinese Participants
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: AZD6793|DRUG: AZD6793|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Nutritional Supplements on Clinical Outcomes in Patients With Prediabetes and Obesity
Status: UNKNOWN
Conditions: PreDiabetes|Obesity
Interventions: DIETARY_SUPPLEMENT: Ivital Control|BEHAVIORAL: lifestyle intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and the Effects on Cerebrospinal Fluid Spectrin Breakdown Product-145 Levels of ABT-957 in Subjects With Mild Alzheimer's Disease and Mild Cognitive Impairment
Status: TERMINATED
Conditions: Alzheimer's Disease|Mild Cognitive Impairment
Interventions: DRUG: ABT-957|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Topical Romidepsin to Treat Early-Stage Cutaneous T-Cell Lymphoma
Status: TERMINATED
Conditions: Mycosis Fungoides|Cutaneous T-Cell Lymphoma|Neoplasms
Interventions: DRUG: Romidepsin (FR901228)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Chlorhexidine Cleansing on Skin Flora of Newborns in Nepal
Status: COMPLETED
Conditions: Bacterial Infection
Interventions: PROCEDURE: skin cleansing with chlorhexidine (0.25%, 0.5%, 1%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Supplementation With Species of Lactobacillus on Anthropometric Measurements
Status: COMPLETED
Conditions: Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Species of Lactobacillus|DIETARY_SUPPLEMENT: lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CDI-988 Safety Study in Healthy Participants
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: CDI-988|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach
Status: RECRUITING
Conditions: Ascending Colon Cancer|Ileocaecal Valve Carcinoma|Cancer Flexure Hepatic|Adenocarcinoma of Hepatic Flexure (Diagnosis)
Interventions: PROCEDURE: the caudal-to-cranial approach|PROCEDURE: the medial-to-lateral approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Impact of Calcium on Woman's Vascular Health
Status: COMPLETED
Conditions: Cardiovascular Diseases|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: Calcium Citrate|OTHER: Low Dietary Calcium|OTHER: High Dietary Calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of Repeat Doses of ACU-4429 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ACU-4429|DRUG: matching placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia
Status: TERMINATED
Conditions: Primary Progressive Nonfluent Aphasia
Interventions: DEVICE: Active iTBS|DEVICE: Sham iTBS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy, Cisplatin, Fluorouracil, and Cetuximab in Treating Patients With Locally Advanced Anal Cancer
Status: TERMINATED
Conditions: Anal Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: cisplatin|DRUG: fluorouracil|OTHER: laboratory biomarker analysis|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History in CCFDN and IBM Syndromes
Status: COMPLETED
Conditions: Inclusion Body Myositis, Sporadic|Inclusion Body Myopathy, Autosomal-recessive|Inclusion Body Myopathy, Autosomal-dominant|Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Interventions: OTHER: Natural History
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Melatonin for Prevention of Delirium in Critically Ill Patients
Status: UNKNOWN
Conditions: Delirium
Interventions: DRUG: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rapid Versus Prolonged Inpatient Up-Titration of Captopril
Status: UNKNOWN
Conditions: Heart Disease
Interventions: DRUG: Captopril|DRUG: Captopril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Pharmacokinetics of GSK1278863 and Metabolites in Normal Subjects and Subjects With Renal Impairment
Status: TERMINATED
Conditions: Anaemia
Interventions: DRUG: 5 mg GSK1278863
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Brain Metastasis
Status: RECRUITING
Conditions: MRI-guided Adaptive Radiotherapy|Non-small Cell Lung Cancer|Brain Metastasis
Interventions: RADIATION: MRI-guided adaptive SRT|RADIATION: Conventional SRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of an Augmented Reality Exercise Program in Older Adults
Status: NOT_YET_RECRUITING
Conditions: Augmented Reality Exercise Program|Traditional Exercise Program|Control Group
Interventions: OTHER: Augmented reality exercise program|OTHER: Traditional exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasonographic and MRI Explorations of Infraspinatus Muscle in Postero-superior Rotator Cuff Tear
Status: UNKNOWN
Conditions: Rotator Cuff Tears
Interventions: OTHER: MRI|OTHER: ultrasonographic explorations
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Esmolol Infusion in Patients Undergoing Craniotomy
Status: COMPLETED
Conditions: Cerebral Arterial Disease|Cerebral Aneurysm
Interventions: DRUG: Esmolol|DRUG: Placebo|DRUG: Propofol and sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Versus Intermittent Nebulization Therapy in Acute Asthma Exacerbation at Emergency Department
Status: NOT_YET_RECRUITING
Conditions: Asthma Exacerbation|Emergency Department|Nebulization
Interventions: DEVICE: continuous nebulization|DEVICE: Intermittent nebulization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct Mechanical Thrombectomy Versus Bridging Therapy
Status: COMPLETED
Conditions: Thrombectomy|Ischemic Stroke|Large-Artery Atherosclerosis (Embolus/Thrombosis)
Interventions: DEVICE: Trevo and or Merci devices for stent retreival|DEVICE: Penumbra system for stent aspiration|DRUG: recombinant tissue plasminogen activator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of an Anti-PD-1 Monoclonal Antibody in Subjects With Advanced Malignancies
Status: UNKNOWN
Conditions: Advanced Malignancies
Interventions: BIOLOGICAL: Toripalimab, Recombinant Humanized anti-PD-1 Monoclonal Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an Adjuvanted Influenza Vaccine Compared to a Non-adjuvanted Influenza Vaccine in Adults ≥65 Years of Age
Status: ACTIVE_NOT_RECRUITING
Conditions: Influenza, Human
Interventions: BIOLOGICAL: aQIV or aTIV|BIOLOGICAL: QIV or TIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Opioid-free Anesthesia in Thyroidectomies
Status: RECRUITING
Conditions: Pain, Post Operative|Pain, Acute|Pain, Chronic|Pain, Neuropathic|Pain, Nociceptive|Ketamine|Dexmedetomidine|Lidocaine|Fentanyl|Analgesia|Analgesics|Analgesics Non-narcotic
Interventions: DRUG: dexmedetomidine-ketamine-lidocaine (DKL)|DRUG: remifentanil infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Management of LUTS by Community Pharmacists
Status: ACTIVE_NOT_RECRUITING
Conditions: Lower Urinary Tract Symptoms
Interventions: OTHER: Pharmacist review of LUTS|OTHER: Pharmacist Provision of healthy aging leaflets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lurbinectedin in FET-Fused Tumors
Status: RECRUITING
Conditions: Ewing Sarcoma|Desmoplastic Small Round Cell Tumor|Pediatric Cancer|Undifferentiated Sarcoma
Interventions: DRUG: Lurbinectedin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: External Pop Out cs vs Conventional Method for Fetal Head Extraction in Repeatedcaesarean Section.
Status: UNKNOWN
Conditions: EPO Teqnique in Fetal Head Extraction
Interventions: PROCEDURE: conventional cs|PROCEDURE: external pop out teqnique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of LY3074828 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LY3074828|DRUG: Placebo|DRUG: LY900021
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcatheter Versus Standard Surgical Mitral Valve Operation for Secondary Mitral Regurgitation
Status: ENROLLING_BY_INVITATION
Conditions: Severe Mitral Valve Regurgitation (Disorder)
Interventions: DEVICE: Trancatheter Edge to Edge Repair|PROCEDURE: Mitral Valve Replacement|PROCEDURE: Restrictive Mitral Annuloplastie|PROCEDURE: Restrictive Mitral Annuloplastie/Subvalvular Repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: New Intubation Method to Achieve Circulatory Stability and to Reduce Number of Intubation Attempts in Neonates
Status: COMPLETED
Conditions: Intubation; Difficult or Failed|Preterm Infant|Term Infant
Interventions: PROCEDURE: New intubation method|PROCEDURE: Conventional intubation method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Intravenous Phenobarbital in Neonatal Seizures
Status: TERMINATED
Conditions: Epilepsy, Benign Neonatal
Interventions: DRUG: Phenobarbital Sodium Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Reduced Dose Zidovudine (AZT) Compared With Standard Dose AZT in Antiretroviral-naïve HIV-infected Patients
Status: UNKNOWN
Conditions: HIV|Zidovudine Adverse Reaction
Interventions: DRUG: Zidovudine|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Mass Balance Study of [14C]-Nanatinostat and Relative Bioavailability Study of Nanatinostat in Patients With Advanced Cancers
Status: RECRUITING
Conditions: Advanced Cancer
Interventions: DRUG: [14C]-Nanatinostat|DRUG: Nanatinostat (free base) tablets in combination with Valganciclovir|DRUG: Nanatinostat mesylate tablets in combination with Valganciclovir|DRUG: Single-agent Nanatinostat (free base) tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Durban Diabetes Study:A Study of the Epidemiology of Diabetes Mellitus in Urban South Africans of African Descent (DDS)
Status: COMPLETED
Conditions: Diabetes Mellitus|Hyperglycemia|Hereditary Diseases|Glucose Intolerance
Interventions: OTHER: blood sample
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Expression-linked and R-ISS-adapted Stratification for First Line Therapy in Multiple Myeloma Patients
Status: RECRUITING
Conditions: Newly Diagnosed Multiple Myeloma
Interventions: DRUG: Isatuximab|DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Dexamethasone|OTHER: autologous stem cell transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Addressing Financial and Social Needs Among Patients With Cancer
Status: RECRUITING
Conditions: Cancer|Financial Hardship
Interventions: BEHAVIORAL: CostCOM (Cost Communication, Financial navigation and counseling)|BEHAVIORAL: Provision of local and national resources to address financial and social needs|BEHAVIORAL: Financial Education|OTHER: Usual care|OTHER: Screening for financial and social needs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparison of Perioperative Analgesic Efficacy of Femoral Nerve Block, Adductor Canal Block and 4in1 Block
Status: RECRUITING
Conditions: Block|Analgesia
Interventions: OTHER: femoral nerve block|OTHER: adductor canal block|OTHER: 4in1 block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: 99mTc-MIRC213 SPECT/CT for the Detection of HER2-positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: 99mTc-MIRC213
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions
Status: RECRUITING
Conditions: Anxiety Disorders and Symptoms|Depressive Symptoms
Interventions: BEHAVIORAL: The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP)|BEHAVIORAL: Space for depression|BEHAVIORAL: Space for resilience
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
Status: ACTIVE_NOT_RECRUITING
Conditions: Heart Failure|Obstructive Sleep Apnea|Central Sleep Apnea
Interventions: OTHER: [C11]Acetate and HED PET
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Recovery From Psychosis in Schizophrenia - The Impact of Cognitive-Behavioral Therapy
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder
Interventions: BEHAVIORAL: Cognitive-Behavior Therapy|OTHER: Standard Psychiatric Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT