pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding
Status: UNKNOWN
Conditions: Acute Bleeding Esophageal Varices|Liver Cirrhosis
Interventions: PROCEDURE: Hepatic venous pressure gradient measurement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS)
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome|PCOS|Insulin Sensitivity
Interventions: DRUG: placebo|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Neck-specific Exercises Effectively Improves Whiplash-associated Disorders.
Status: NOT_YET_RECRUITING
Conditions: Whiplash-associated Disorders
Interventions: PROCEDURE: specific neck exercises with the Spinetrack|PROCEDURE: specific neck exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication
Status: COMPLETED
Conditions: Open Angle Glaucoma
Interventions: DEVICE: Two trabecular micro-bypass stents (iStent inject)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compared to Sporanox® in Healthy Subjects
Status: COMPLETED
Conditions: Renal Insufficiency, Chronic|Hepatic Insufficiency|Healthy
Interventions: DRUG: Sporanox|DRUG: Diclofenac Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: The Efficacy of Glucagon Like Peptide (GLP) - 1(7-36) Amide for Glycemic Control in Critically Ill Patients
Status: TERMINATED
Conditions: Critically Ill|Hypoglycemia
Interventions: DRUG: Glucagon-Like Peptide-1|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-surgical Treatment of Periimplantitis - Conventional Hand Instrumentation Versus Air-polishing
Status: RECRUITING
Conditions: Periimplantitis
Interventions: DEVICE: erythritol jet|DEVICE: Manual instrumentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess STS101 in the Acute Treatment of Migraine
Status: COMPLETED
Conditions: Migraine|Migraine With Aura|Migraine Without Aura
Interventions: DRUG: Dihydroergotamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia
Status: RECRUITING
Conditions: Trigeminal Neuralgia
Interventions: DRUG: Botulinum toxin A|OTHER: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Benefit of Add On DLBS1033 for Ischemic Stroke Patient
Status: UNKNOWN
Conditions: Ischemic Stroke
Interventions: DRUG: DLBS1033|DRUG: Aspirin|DRUG: Statin|DRUG: Vit B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT
Status: RECRUITING
Conditions: Microtia|Dysbiosis|Alcohol Drinking|HIV Infections|Cardiovascular Diseases
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Single Dose of PRS-060 Administered by Oral Inhalation or IV Infusion in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: PRS-060|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Hall Technique in Atypical Lesions on Primary Teeth
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Dental Restoration with Stainless Crown|OTHER: Dental Restoration with Composite Resin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Overlaying a Visual Wound Trace Onto Its Thermal Image in a Wound Clinic
Status: COMPLETED
Conditions: Wounds and Injuries
Interventions: DEVICE: Scout takes visual and thermal images of external wounds|DEVICE: ImageReview's visual perimeter trace of the external wound|DEVICE: ImageReview's External Wound Trace Overlay|DEVICE: ImageReview's unaffected reference area selected|DEVICE: Adjacent tissue trace of the wound trace overlay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: RO7062931|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ologen Collagen Matrix Safety and Effective Comparison With Mitomycin-C(MMC) in Glaucoma Surgery
Status: COMPLETED
Conditions: Open Angle Glaucoma
Interventions: DEVICE: Collagen Matrix in Glaucoma Filtering Surgery|DRUG: Mitomycin-C(MMC) and glaucoma filtering surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reward Mechanisms in Obesity
Status: COMPLETED
Conditions: Obesity
Interventions: DRUG: Liraglutide (Saxenda) 6Mg/Ml Inj Pen 3Ml or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Learn More About the Effect of Itraconazole (ITZ) Given Repeatedly by Mouth on the Way How the Study Drug BAY1902607 Given One Time by Mouth Acts in the Human Body of Healthy Male Participants
Status: COMPLETED
Conditions: Drug Interactions
Interventions: DRUG: BAY1902607|DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: DA-13-007 Versus Sculptra for the Treatment of Nasolabial Folds Wrinkles
Status: COMPLETED
Conditions: Face; Atrophy
Interventions: DEVICE: DA-13-007 right with left side Sculptra left side|DEVICE: DA-13-007 left with left side Sculptra right side
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Repetitive Transcranial Magnetic Stimulation and Venlafaxine in Depression
Status: COMPLETED
Conditions: Unipolar Depression
Interventions: OTHER: active venlafaxine and active rTMS-repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed|OTHER: active rTMS -repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and sham venlafaxine|OTHER: sham rTMS- repetitive transcranial magnetic stimulator, Inomed and Alpine Biomed and active venlafaxine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Feasibility of a Nurse-led Person-centered Education Program
Status: NOT_YET_RECRUITING
Conditions: Self-Management|Behavior|Patient Empowerment
Interventions: OTHER: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment
Status: COMPLETED
Conditions: Methylmalonic Aciduria and Homocystinuria,Cblc Type|Genetic Disease|Retinopathy
Interventions: DRUG: Epi-743|OTHER: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BI 10773 add-on to Metformin in Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: BI 10773|DRUG: placebo|DRUG: sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamics of Mitiglinide/Sitagliptin Compared to Mitiglinide and Sitagliptin
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Sitagliptin|DRUG: Mitiglinide|DRUG: Sitagliptin, Mitiglinide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Normovolemic Hemodilution in Complex Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Surgery|Acute Kidney Injury|Congenital Heart Disease|Aortic Surgery
Interventions: BIOLOGICAL: Acute normovolemic hemodilution (ANH)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Acceptability of a Soy-fiber-maize Complementary Food in Malawi.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Soy-fiber-maize|DIETARY_SUPPLEMENT: Maize
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: AK112 in Advanced Non-Small Cell Lung Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Non-small-cell Lung Cancer
Interventions: DRUG: AK112|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Radial Extracorporeal Shock Wave Therapy and Supervised Exercises in Lateral Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis
Interventions: DEVICE: rESWT|OTHER: Supervised exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Use of Benralizumab in Patients With Bullous Pemphigoid.
Status: TERMINATED
Conditions: Bullous Pemphigoid
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Nordic Walking in Water on Cerebrovascular Function and Cognitive Impairment in Elderly With Type 2 Diabetes
Status: RECRUITING
Conditions: Elderly With Type 2 Diabetes
Interventions: OTHER: Nordic walking in water|OTHER: No exercise intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Antidepressants in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Depression
Interventions: DRUG: paroxetine|DRUG: venlafaxine|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Equine Assisted Services in Children and Adolescents With Mental Illness
Status: WITHDRAWN
Conditions: Mental Disorders, Child|Mental Disorder in Adolescence|Anxiety Disorders|Anxiety|Depression|Anorexia Nervosa|School Fear
Interventions: OTHER: Equine assisted therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Improvement of Insulin Resistance After Bariatric Surgery
Status: COMPLETED
Conditions: Obesity|Bariatric Surgery Candidate|Insulin Tolerance
Interventions: PROCEDURE: Roux-en-Y gastric bypass|PROCEDURE: Laparoscopic adjustable gastric banding
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
Status: NOT_YET_RECRUITING
Conditions: Chronic Pain|Prescription Opioid Misuse|Substance-Related Disorders|Pain|Narcotic-Related Disorders|Chemically-Induced Disorders|Mental Disorders|Opioid-Related Disorders|Neurologic Manifestations
Interventions: BEHAVIORAL: Mindfulness Oriented Recovery Enhancement|BEHAVIORAL: Patient-Centered Chronic Pain Management Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
Status: UNKNOWN
Conditions: Depression
Interventions: DRUG: Etomidate|DRUG: Ketamine|PROCEDURE: Hyperventilation|PROCEDURE: Electroconvulsive therapy (ECT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Geptanolimab(GB226) Combined With Fruquintinib in the Treatment of Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Geptanolimab Injection|DRUG: Fruquintinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bi-Polar Radio-Frequency and Electrical Muscle Stimulation for Symptoms of Mixed Urinary Incontinence (MUI)
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: DEVICE: FormaV and VTone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lipid-lowering Effect of Plant Stanol Drink
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Drink that contains plant stanols|DIETARY_SUPPLEMENT: Placebo drink
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Striving to Quit: First Breath
Status: COMPLETED
Conditions: Smoking Cessation|Smoking|Nicotine Dependence
Interventions: BEHAVIORAL: Incentives for abstinence and treatment engagement|BEHAVIORAL: Attendance incentive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Oxaliplatin and Radiation Therapy in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DRUG: oxaliplatin|DRUG: gemcitabine|PROCEDURE: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Differential Mechanisms of Dyspnea Relief in Advanced COPD: Opiates vs. Bronchodilators
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Fentanyl Citrate|DRUG: Combivent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: School-Based Mental Health Services for Urban Children
Status: COMPLETED
Conditions: Conduct Disorder|Oppositional Defiant Disorder|Attention Deficit Disorder With Hyperactivity
Interventions: BEHAVIORAL: Community mental health consultation model program|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Safety and Tolerability Study of ILB in Patients With Amyothrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis|Motor Neuron Disease
Interventions: DRUG: ILB
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Soliqua on Glucose Variability in Type 2 Patients Among South Asians
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Basal insulin glargine and lixisenatide|DRUG: Basal insulin Basaglar/Lantus + gliclazide MR|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paricalcitol Plus Gemcitabine and Nab-paclitaxel in Metastatic Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Gemcitabine|DRUG: Nab-paclitaxel|DRUG: Paricalcitol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of the Physiological Response to Sugar on Brain Activity and Behavior
Status: RECRUITING
Conditions: Food Preferences|Appetitive Behavior
Interventions: OTHER: Conditioned Stimulus: Sucrose (aim 1)|OTHER: Conditioned Stimulus: Glucose (aim 1)|OTHER: Conditioned Stimulus: Fructose (aim 1)|OTHER: Conditioned Stimulus: Sucrose (aim 2)|OTHER: Conditioned Stimulus: High Fructose Corn Syrup (aim 2)|OTHER: Conditioned Stimulus: Sucrose + Non-nutritive Sweetener (aim 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Evaluation of Ropinirole CR-RLS ( SK&F101468)Tablets in Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: ropinirole controlled release (CR)-RLS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Sexually Transmitted Infections|HIV Infections
Interventions: BEHAVIORAL: IMARA (intervention group)|BEHAVIORAL: Health promotion control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Brain Activations and Physiological Responses Using NeuroBiofeedback in Patients With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis|Mood Disorders|Cognitive Impairment
Interventions: DEVICE: Rehacor-T|BEHAVIORAL: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Droplet-digital PCR for the Detection of Circulating Cell-free DNA in Patients With Cystic Echinococcosis: an Exploratory Study
Status: RECRUITING
Conditions: Cystic Echinococcosis
Interventions: DIAGNOSTIC_TEST: ddPCR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning
Status: ACTIVE_NOT_RECRUITING
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Dual Task (DT) training|BEHAVIORAL: Single Task (ST) training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Evaluation for the Treatment of Allergy Against Mites
Status: RECRUITING
Conditions: Rhinitis, Allergic|Rhinoconjunctivitis|Asthma, Allergic
Interventions: BIOLOGICAL: 10,000 MM09|BIOLOGICAL: 30,000 MM09|BIOLOGICAL: Placebo subcutaneous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Hang Clean and Half Squat Training Program Among Basketball Players
Status: RECRUITING
Conditions: Weight-Bearing Strengthening Program|Muscle Strength|Basketball
Interventions: OTHER: hang clean training|OTHER: half squat training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: "No-Touch" Radiofrequency Ablation for Small Hepatocellular Carcinoma (≤ 3cm): A Prospective Multicenter Study
Status: TERMINATED
Conditions: Radiofrequency Ablation|Microwave Ablation
Interventions: PROCEDURE: "No-Touch" Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DIEP (Deep Inferior Epigastric Artery Perforator) Flap Sensory Recovery Following Neurotization
Status: UNKNOWN
Conditions: Sensitisation
Interventions: PROCEDURE: Sensory neurotization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Inhaled PT005 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Inhaled PT005|DRUG: Inhaled PT005|DRUG: Inhaled PT005|DRUG: Inhaled placebo|DRUG: Formoterol Fumarate 12 mcg (Foradil Aerolizer)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluate Long-term Safety and Efficacy of ORADUR®-Methylphenidate in Children and Adolescents With ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: ORADUR®-Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Research of Standard Diagnosis and Treatment for HSPN With Mild Proteinuria in Children
Status: UNKNOWN
Conditions: Henoch-Schoenlein Purpura Nephritis
Interventions: DRUG: Prednisone|DRUG: ACEI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Addition of Excimer Laser to Treatment With Acitretin Tablets for Psoriasis of the Palms and Soles
Status: TERMINATED
Conditions: Psoriasis, Skin or Nails
Interventions: DEVICE: Excimer laser|DRUG: Acitretin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare Efficacy and Safety of CT-P39 and EU-approved Xolair in Patients With Chronic Spontaneous Urticaria
Status: COMPLETED
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: CT-P39|BIOLOGICAL: EU-approved Xolair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Personalized TCR-T: Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)
Status: ENROLLING_BY_INVITATION
Conditions: Malignant Epithelial Neoplasms
Interventions: BIOLOGICAL: TCR-transduced T cells|DRUG: CDX-1140|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Disulfiram and Chemotherapy in Treating Patients With Refractory Solid Tumors or Metastatic Pancreatic Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma|Refractory Malignant Solid Neoplasm|Stage IV Pancreatic Cancer AJCC v8
Interventions: DRUG: Chemotherapy|DRUG: Disulfiram|DRUG: Gemcitabine Hydrochloride|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Effects of Stabilization Exercises and Muscle Energy Techniques in Sacroiliac Joint Pain
Status: COMPLETED
Conditions: Sacroiliac Joint Somatic Dysfunction
Interventions: OTHER: Stabilization exercises|OTHER: Muscle energy techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the Spinal Manipulative Therapy and Myofascial Release in Individuals With Non-specific Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low Back Pain
Interventions: OTHER: Spinal manipulation/myofascial release|OTHER: Spinal manipulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Danavorexton (TAK-925) in Adults With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea
Interventions: DRUG: Danavorexton|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Refinement and Testing of Recruitment Methodology for Behavioral Medication Adherence Interventions Using Behavioral Science-based Approaches
Status: NOT_YET_RECRUITING
Conditions: Diabetes|Pharmacist-Patient Relations|Medication Adherence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Buccal Infiltration Anesthesia Versus Inferior Alveolar Nerve Block Anesthesia
Status: COMPLETED
Conditions: Anesthesia
Interventions: PROCEDURE: Single buccal infiltration|PROCEDURE: Inferior alveolar nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Agomelatine or Fluoxentine on Heart Rate Variability in Patients With Major Depressive Disorder
Status: WITHDRAWN
Conditions: Depressive Disorder, Major
Interventions: DRUG: Agomelatine|DRUG: Fluoxentine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of Modified Time-restricted Feeding in Preventing Progression of Non-Alcoholic Fatty Liver Disease (NAFLD).
Status: UNKNOWN
Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: BEHAVIORAL: Conventional diet|BEHAVIORAL: Modified Time-restricted Feeding|BEHAVIORAL: Physical activity|BEHAVIORAL: Restricted consumption of sweetened beverages
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Treatment Based Neuroscience Education in Knee
Status: NOT_YET_RECRUITING
Conditions: Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Injuries
Interventions: OTHER: Best current rehabilitation protocol|OTHER: Cross-training protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cerebral Antibiotics Distribution After Acute Brain Injury
Status: COMPLETED
Conditions: Bacterial Infection|Brain Injury
Interventions: DRUG: cefotaxime|DRUG: Metronidazole|DRUG: Ciprofloxacin|DRUG: Fosfocine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Early-onset and Late-onset Sporadic Alzheimer's Disease (AD)
Status: UNKNOWN
Conditions: Alzheimer's Disease
Interventions: BIOLOGICAL: Clinic and neuropsychologic evaluation|RADIATION: MRI|PROCEDURE: PET|BIOLOGICAL: Apolipoprotein E genotyping|BIOLOGICAL: Study of cerebrospinal fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Camrelizumab Plus Apatinib in Combination With GEMOX (Gemcitabine and Oxaliplatin ) in Patients With Locally Advanced Biliary Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Advanced Biliary Tract Carcinoma
Interventions: DRUG: Camrelizumab, apatinib, gemcitabine, oxaliplatin, tegafur
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parker Flex-it Stylet Versus Malleable Stylet in Orotracheal Intubation Using a Fiber-optic Laryngoscope
Status: COMPLETED
Conditions: Orotracheal Intubation
Interventions: DEVICE: Parker Flex-it Directional Stylet|DEVICE: Conventional Malleable Stylet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Evaluation of Endovascular Treatment in Acute Intracranial Distal Medium Vessel Occlusion Stroke
Status: RECRUITING
Conditions: Acute Ischemic Stroke|Endovascular Thrombectomy
Interventions: PROCEDURE: endovascular treatment|OTHER: Standard medical management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Adapted Mindfulness-based Stress Reduction Program for Psycho-socially Vulnerable Pregnant Women.
Status: COMPLETED
Conditions: Pregnancy, High Risk
Interventions: BEHAVIORAL: Prenatal MBSR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DRUG: glucosamine|DRUG: chondroitin sulfate|DRUG: glucosamine and chondroitin sulfate combined|DRUG: celecoxib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: the Horsens Aarhus FemoroAcetabular Impingement Syndrome Training Pilot Study
Status: UNKNOWN
Conditions: Femoroacetabular Impingement
Interventions: PROCEDURE: Physiotherapist-led training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Super Skills for Life Effectiveness in the Online Modality
Status: COMPLETED
Conditions: Depressive Disorder|Depressive Symptoms|Anxiety Disorders|Anxiety Disorders and Symptoms|Mood Disorders|Child Mental Disorder|Emotional Disorder
Interventions: BEHAVIORAL: Super Skills for Life program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Conflict Between Maternal Autonomy and Child Health in Substance-use
Status: COMPLETED
Conditions: Substance-Related Disorders|Alcohol-Related Disorders|Amphetamine-Related Disorders|Inhalant Abuse|Cocaine-Related Disorders|Opioid-Related Disorders|Marijuana Abuse|Substance Abuse, Intravenous|Neonatal Abstinence Syndrome|Pregnancy|Pregnancy, High-Risk
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ceftolozane-tazobactam Versus Meropenem for ESBL and AmpC-producing Enterobacterales Bloodstream Infection
Status: WITHDRAWN
Conditions: Bacteremia Caused by Gram-Negative Bacteria
Interventions: DRUG: Ceftolozane-Tazobactam|DRUG: Meropenem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Predictive Methods & Product Performance in Healthy Adults for Pediatric Patients, A Case Study: Furosemide
Status: WITHDRAWN
Conditions: Medication Absorption
Interventions: DIETARY_SUPPLEMENT: Water|DIETARY_SUPPLEMENT: Parmalat™ Whole Milk|DIETARY_SUPPLEMENT: Similac Pro-Advance™|DIETARY_SUPPLEMENT: Ensure Plus™|DRUG: Furosemide 20 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimizing Dosing of Colistin for Infections Resistant to All Other Antibiotics, Approved NIH Protocol Dated 12.06.07(DMID Protocol #07-0036)
Status: COMPLETED
Conditions: Bacteremia|Pseudomonas Infections
Interventions: PROCEDURE: Blood draws|OTHER: Blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A 3 Year Follow-up Prospective Open Randomized Trial of TVT Versus Colposuspension for Primary Stress Incontinence
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: PROCEDURE: Surgical treatment: TVT|PROCEDURE: Surgical treatment: colposuspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RADVAX: A Stratified Phase I Trial of Pembrolizumab With Hypofractionated Radiotherapy in Patients With Advanced and Metastatic Cancers
Status: COMPLETED
Conditions: Metastatic Cancers
Interventions: DRUG: Pembrolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Performance of Rigid Gas Permeable (RGP) Scleral Contact Lenses With a Passive Artificial Iris
Status: TERMINATED
Conditions: Low Vision
Interventions: DEVICE: Scleral contact lens without a passive artificial iris|DEVICE: Scleral contact lens with a passive artificial iris with low contrast (<1:5)|DEVICE: Scleral contact lens with a passive artificial iris with high contrast (>1:5)|DRUG: Tropicamide and phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Portal Flu Vaccine Reminders_RCT 4
Status: COMPLETED
Conditions: Influenza|Respiratory Tract Infections
Interventions: BEHAVIORAL: Text Message R/R with Direct Appointment Schedule Link|BEHAVIORAL: Text Message R/R without Direct Appointment Schedule Link|BEHAVIORAL: Text Pre-Appointment Reminder|BEHAVIORAL: Portal Message R/R with Direct Appointment Schedule Link|BEHAVIORAL: Portal Message R/R without Direct Appointment Schedule Link|BEHAVIORAL: Portal Pre-Appointment Reminder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Immunotherapy Clearance and Phenotype of Circulating Tumor Cells in Lung and Head and Neck Cancers
Status: RECRUITING
Conditions: Metastatic NSCLC|Metastatic Head and Neck Cancer
Interventions: OTHER: Blood draws
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Visually Induced Motion Sickness in Healthy Volunteers
Status: COMPLETED
Conditions: Visually Induced Motion Sickness in Healthy Volunteers
Interventions: DEVICE: Transcutaneous vagal nerve stimulation|DEVICE: Sham vagal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OCT and OCT-Angiography Biomarkers of Treatment Response to Dexamethasone Implant in Macular Edema Due to Retinal Vascular Diseases - DME and RVO
Status: RECRUITING
Conditions: Diabetic Macular Edema|Macular Edema Due to Diabetes Mellitus|Retinal Vein Occlusion
Interventions: DEVICE: dexamethasone implant
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Adult Adipose-Derived Stem Cell Injection Into Partial Thickness Rotator Cuff Tears
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: DEVICE: Adipose-derived stem cells|DEVICE: cortisone injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Effects of Post-Immediate Psychotherapeutic Interventions in Secondary Prevention of Psychotraumatic Disorders
Status: UNKNOWN
Conditions: PTSD Post Traumatic Syndrome Disorder
Interventions: PROCEDURE: Post-immediate Psychotherapeutic Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes
Status: UNKNOWN
Conditions: Prediabetes|Impaired Fasting Glucose|Impaired Glucose Tolerance
Interventions: DIETARY_SUPPLEMENT: Berberine|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Dexamethasone|DRUG: Leflunomide|DRUG: Pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IKKb-matured, RNA-loaded Dendritic Cells for Metastasised Uveal Melanoma
Status: UNKNOWN
Conditions: Melanoma, Uveal Metastatic
Interventions: BIOLOGICAL: Vaccination with IKKb matured Dendritic Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veterans' Pain Care Organizational Improvement Comparative Effectiveness Study
Status: COMPLETED
Conditions: Chronic Pain
Interventions: OTHER: Medication management|OTHER: Non-pharmacological pain management|DRUG: Buprenorphine-Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke
Status: COMPLETED
Conditions: Periodontal Diseases|Saliva Altered|Stroke
Interventions: DIAGNOSTIC_TEST: saliva stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Immunogenicity, Reatogenicity and Safety of Double Viral Vaccine (MR) for Measles and Rubella
Status: COMPLETED
Conditions: Rubella|Measles
Interventions: BIOLOGICAL: Measles and Rubella vaccine|BIOLOGICAL: Measles, Mumps and Rubella vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Detecting Abnormal Blood Clotting in Patients With Metastatic Cancer Undergoing Surgery
Status: COMPLETED
Conditions: Thromboembolism|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: OTHER: coagulation study|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis|OTHER: physiologic testing|PROCEDURE: study of high risk factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients With Chronic Kidney Disease-Associated Pruritus
Status: UNKNOWN
Conditions: Pruritus
Interventions: DRUG: HSK21542|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation for Controlling Pre-Local Anesthetic Injection Pain
Status: COMPLETED
Conditions: Fear Needles
Interventions: DEVICE: Photobiomodulation|DRUG: Mepivacaine hydrochloride in combination with epinephrine|DEVICE: Photobiomodulation simulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Pharmacokinetics of Isavuconazole in Healthy Non-Elderly and Elderly Male and Female Subjects
Status: COMPLETED
Conditions: Pharmacokinetics of Isavuconazole|Healthy Volunteers|Safety and Tolerability in Elderly
Interventions: DRUG: isavuconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Preventing the Loss of Muscle and Function in Hospitalized Older Adults
Status: COMPLETED
Conditions: Muscular Atrophy
Interventions: DEVICE: NMES|DIETARY_SUPPLEMENT: Protein|DIETARY_SUPPLEMENT: non-protein placebo supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Telerehabilitation Using Mirror Therapy in Patients With Phantom Limb Pain Following Lower Limb Amputation.
Status: UNKNOWN
Conditions: Phantom Limb Pain
Interventions: OTHER: Physical/Occupational therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Measuring Asthma Control In Pediatric And Adolescent Subjects Whose Asthma Is Worsened By Activity Or Exercise
Status: COMPLETED
Conditions: Bronchospasm|Activity/Exercise Induced Bronchospasm
Interventions: DRUG: Fluticasone propionate/salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Adipose Tissue Extract and Platelet-rich Plasma Use for Wound Healing
Status: COMPLETED
Conditions: Wound Healing Disturbance of
Interventions: BIOLOGICAL: ADIPOSE TISSUE EXTRACT|BIOLOGICAL: PLATELET-RICH PLASMA GEL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Continuous or Intermittent S-1 Combined With Oxaliplatin in Recurrent or Metastatic Gastric Carcinoma
Status: UNKNOWN
Conditions: Stomach Neoplasms
Interventions: DRUG: S-1,oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Subscapularis Repair in Reverse Shoulder Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Arthropathy Shoulder
Interventions: OTHER: Repair|OTHER: Standard Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
Status: RECRUITING
Conditions: Advanced Esophageal Adenocarcinoma|Advanced Gastric Adenocarcinoma|Advanced Gastroesophageal Junction Adenocarcinoma|Clinical Stage III Esophageal Adenocarcinoma AJCC v8|Clinical Stage III Gastric Cancer AJCC v8|Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8|Clinical Stage IV Esophageal Adenocarcinoma AJCC v8|Clinical Stage IV Gastric Cancer AJCC v8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8|Metastatic Esophageal Adenocarcinoma|Metastatic Gastric Adenocarcinoma|Metastatic Gastroesophageal Junction Adenocarcinoma|Unresectable Esophageal Adenocarcinoma|Unresectable Gastric Adenocarcinoma|Unresectable Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Fluorouracil|DRUG: Leucovorin Calcium|DRUG: Oxaliplatin|DRUG: Irinotecan|BIOLOGICAL: Nivolumab|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Computed Tomography|PROCEDURE: Biospecimen Collection|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Ocrelizumab on B-cell Tolerance Defect in Relapsing Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DRUG: Ocrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endocervical Evaluation With the Curette Versus Cytobrush for the Diagnosis of Dysplasia of the Uterine Cervix
Status: COMPLETED
Conditions: Cervical Dysplasia
Interventions: PROCEDURE: Curette v/s endocervical brush
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled Study
Status: COMPLETED
Conditions: Familial Adenomatous Polyposis
Interventions: DRUG: Metformin|DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Cognition and Gestational Duration With Targeted Nutrition
Status: RECRUITING
Conditions: Malnutrition in Pregnancy|Preterm Birth|Child Development|Postpartum Depression|Antepartum Depression
Interventions: DIETARY_SUPPLEMENT: M-RUSF+ (Maternal Ready-to-Use Supplementary Food + DHA/EPA/choline)|DIETARY_SUPPLEMENT: M-RUSF (Maternal Ready-to-Use Supplementary Food)|DRUG: Azithromycin|DRUG: Albendazole|DRUG: Sulfadoxine pyrimethamine|BEHAVIORAL: Cognitive behavioral therapy|OTHER: Insecticide-treated mosquito net
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT