pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Multiple Ascending Dose Study of BMS-929075 in Hepatitis C Virus (HCV) Infected Patients
Status: WITHDRAWN
Conditions: Chronic Hepatitis C
Interventions: DRUG: BMS-929075|DRUG: BMS-929075|DRUG: BMS-929075|DRUG: BMS-929075|DRUG: Placebo matching BMS-929075|DRUG: Placebo matching BMS-929075
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Rectal Adenocarcinoma
Interventions: DRUG: LY2157299|DRUG: Capecitabine|DRUG: Fluorouracil|PROCEDURE: Tumor specific mesorectal excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias
Status: COMPLETED
Conditions: Myelodysplastic Syndrome|Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia|Chronic Myelomonocytic Leukemia
Interventions: DRUG: Clofarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Sorafenib Trial in Advanced and/or Recurrent Gastric Adenocarcinoma: Treatment Evaluation: STARGATE
Status: COMPLETED
Conditions: Malignant Neoplasm of Stomach|Effects of Chemotherapy
Interventions: DRUG: Capecitabine/Cisplatin + Sorafenib|DRUG: Capecitabine/Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Assessing the Immunogenicity and Safety of Two Influenza Vaccine Strategies Among Severe Obese Adult Patients
Status: COMPLETED
Conditions: Morbid Obesity|Severe Obesity
Interventions: BIOLOGICAL: Supemtek®|BIOLOGICAL: Vaxigriptetra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Dynamic Congruence Total Knee Replacement vs Posterior-stabilized
Status: COMPLETED
Conditions: Osteo Arthritis Knee|Surgery|Joint Diseases
Interventions: PROCEDURE: Total knee replacement|DIAGNOSTIC_TEST: Biomechanics|DEVICE: NexGen Ps or Bioimplanti K-MOD implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Visualization Versus Electrical Nerve Stimulation
Status: COMPLETED
Conditions: Trauma to the Arm, Shoulder, Elbow, Forearm, or Hand
Interventions: DEVICE: Ultrasound (Sonosite Titan T-shaped ultrasound probe)|DEVICE: Electrical Nerve Stimulation (Stimuplex (B Braun) needle)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)
Status: COMPLETED
Conditions: Atrial Fibrillation|Persistent Common Pulmonary Vein
Interventions: DRUG: Adenosine arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Traditional Chinese Medicine on AECOPD Patients
Status: UNKNOWN
Conditions: Pulmonary Disease, Chronic Obstructive|Acute Exacerbation|Medicine, Chinese Traditional
Interventions: DRUG: TCM and conventional drug|DRUG: TCM placebo and conventional drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Two Aquatic Training Models in Physiological Parameters of Elderly Dyslipidemic Women.
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: OTHER: Water aerobics training.|OTHER: Water resistance training.|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Assisted ICSI; Has it Role Whatsoever?
Status: SUSPENDED
Conditions: Laser Assistance to Improve ICSI Outcome
Interventions: PROCEDURE: Laser Assisted ICSI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effects of Angiotensin Converting Enzyme Inhibitors on Patency of Arterio-Venous Fistulas: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Vascular Access Complication
Interventions: DRUG: Losartan Potassium|DRUG: multi-vitamins
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of QDOT MICRO™ Catheter for Pulmonary Vein Isolation in Subjects With Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: RF Ablation with QDOT Micro
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Trial to Evaluate the Pharmacokinetic Properties and Safety of CKD-828 in Healthy Subjects
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: D064+D701|DRUG: CKD-828 Formulation 1|DRUG: CKD-828 Formulation 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Arsenic Trioxide TACE and Intravenous Administration in Unresectable Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Carcinoma, Hepatocellular
Interventions: DEVICE: Arsenic trioxide TACE|DRUG: Arsenic trioxide intravenous infusion|DRUG: lipiodol|DRUG: NaCl solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: By Comparing TPF Induction Chemotherapy Combined With Nimotuzumab Concurrent Radiotherapy and Cisplatin Concurrent Radio-chemotherapy for Locally Advanced NPC
Status: UNKNOWN
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Nimotuzumab|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Tocilizumab in Combination With Methotrexate for Treatment of Moderate to Severe Rheumatoid Arthritis Patients
Status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Interventions: DRUG: Tocilizumab + methotrexate(MTX)|DRUG: Tocilizumab placebo + methotrexate(MTX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral Tubing
Status: UNKNOWN
Conditions: Ulcerative Colitis
Interventions: DRUG: fecal microbiota transplantation|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Secukinumab (AIN457)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy of Allogeneic Endothelial Progenitor Cells (EPCs) in Patients With Critical Limb Ischemia
Status: RECRUITING
Conditions: Critical Limb Ischemia
Interventions: DRUG: EPCs|BEHAVIORAL: Clinical standard treatment (CST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skillful Neglect Vs Repair For Subscapularis Tear Associated With Posterosuperior Cuff Tears Repair.
Status: RECRUITING
Conditions: Subscapularis Muscle Strain
Interventions: PROCEDURE: skillful neglect Of upper subscapularis tear in Lafosse type 1 and type 2 with long head biceps tenotomy .|PROCEDURE: arthroscopic repair Of upper subscapularis tear in Lafosse type 1 and type 2 with long head biceps tenotomy .
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction
Status: COMPLETED
Conditions: Postoperative Cognitive Dysfunction
Interventions: DRUG: Dexamethasone|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Intermittent Serial Casting on Spastic Wrist Flexion Deformity
Status: COMPLETED
Conditions: Cerebral Palsy
Interventions: DRUG: Botulinum toxin A|OTHER: Occupational Therapy|OTHER: Intermittent serial casting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Culturally Based Brief Expressive Writing Intervention for the Improvement of Health in Chinese Immigrant Stage 0-III Breast Cancer Survivors, Writing to Heal Study
Status: RECRUITING
Conditions: Anatomic Stage 0 Breast Cancer AJCC v8|Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Prognostic Stage 0 Breast Cancer AJCC v8|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8
Interventions: OTHER: Behavioral, Psychological or Informational Intervention|OTHER: Behavioral, Psychological or Informational Intervention|OTHER: Best Practice|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Near-peer Tutoring Compared With a Standard Faculty-led Course for Undergraduate Training in Abdominal Ultrasound.
Status: COMPLETED
Conditions: Ultrasonography|Educational Techniques
Interventions: OTHER: Blended learning|OTHER: Standard course
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma
Status: TERMINATED
Conditions: Chronic Lymphocytic Leukemia|B-Cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Bendamustine|DRUG: Pentostatin|DRUG: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Composition for Treating Spermatogenesis and Semen Disorders / FPT-20
Status: COMPLETED
Conditions: Spermatogenesis and Semen Disorders
Interventions: DRUG: FPT-20
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Safety and Pharmacokinetics of MOXR0916 and Atezolizumab (Also Known as MPDL3280A or Anti-PD-L1) in Participants With Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 [PD-L1] antibody|DRUG: MOXR0916, a humanized agonist anti-OX40 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicenter Investigation of Trabecular Micro-Bypass Stents vs. Laser Trabeculoplasty
Status: TERMINATED
Conditions: Primary Open-Angle Glaucoma
Interventions: DEVICE: Stents|PROCEDURE: Laser|DEVICE: Laser Trabeculoplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
Status: TERMINATED
Conditions: Alzheimer Disease|Parkinson Disease|Frontal Dementia|Huntington Disease|Traumatic Brain Injury|Stroke
Interventions: BEHAVIORAL: social cognition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Early Bactericidal Activity, Safety & Tolerability of Oral GSK3036656 in a Dual Combination With Novel and Established Antitubercular Agents, or Standard of Care in Adults With Rifampicin Susceptible Pulmonary Tuberculosis
Status: RECRUITING
Conditions: Tuberculosis
Interventions: DRUG: GSK3036656|DRUG: Bedaquiline|DRUG: Delamanid|DRUG: RIFAFOUR e-275|DRUG: BTZ-043
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.
Status: RECRUITING
Conditions: Oral Mucositis (Ulcerative) Due to Radiation
Interventions: DRUG: N-Acetyl-Cysteine with Institutional standard care|DRUG: Institutional standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Surgical Repercussions in Respiratory System in Patients With Post-Traumatic Brachial Plexus Injuries: A Prospective Cohort Study
Status: COMPLETED
Conditions: Brachial Plexus Injury|Respiratory Evaluation
Interventions: DEVICE: optoelectronic plethysmography|DEVICE: diaphragmatic ultrasound|DEVICE: Postural evaluation|DEVICE: Pain evaluation|DEVICE: Evaluation of the function|DEVICE: Functional capacity assessment|DEVICE: Quality of life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Further Studies of Attention Deficit Disorder - Residual Type (RT)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: methylphenidate|DRUG: methylphenidate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial With Taxotere and Cisplatin in Non-operable Adrenocortical Carcinoma
Status: COMPLETED
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: cisplatin, taxotere
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: ARC-520|OTHER: Placebo|DRUG: entecavir|DRUG: antihistamine|DRUG: tenofovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phone-Delivered Psychological Intervention (t-CETA) for Mental Health Problems in 8-17 Year-Old Syrian Refugee Children
Status: COMPLETED
Conditions: Depression|Anxiety|PTSD|Conduct Disorder|Oppositional Defiant Disorder
Interventions: BEHAVIORAL: t-CETA|BEHAVIORAL: Médecins du Monde treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetics (PK) of Etrumadenant Tablet and Capsule Formulations in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Etrumadenant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irinotecan Plus Radiation Therapy Followed By Chemotherapy in Treating Patients With Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: carmustine|DRUG: irinotecan hydrochloride|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis
Status: RECRUITING
Conditions: Spondyloarthritis|Ruminococcus Gnavus
Interventions: PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Oral Anthocyanins on Insulin Resistance
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DIETARY_SUPPLEMENT: Mirtoselect
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Baloxavir Marboxil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Steroid in Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Arthropathy of Knee
Interventions: DRUG: Dexamethasone Sodium Phosphate|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Individualized Dose Prescription in Advanced Stage Lung Cancer Patients Using Modern (Chemo)Radiotherapy
Status: TERMINATED
Conditions: Stage III Non-small Cell Lung Cancer|Individualized Radiation Dose Escalation
Interventions: RADIATION: Individualized dose escalation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Ipilimumab Plus Dacarbazine in Japanese Patients With Advanced Melanoma
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Negative Pressure Wound Therapy (PREVENA) Versus Standard Dressings for Incision Management After Renal Transplant
Status: UNKNOWN
Conditions: Wound Complication
Interventions: DEVICE: Closed Incision Negative Pressure Wound Therapy (Prevena)|OTHER: Control - Standard Dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Dose Escalation Study of GSK2879552 in Subjects With Acute Myeloid Leukemia (AML)
Status: TERMINATED
Conditions: Leukaemia, Myelocytic, Acute
Interventions: DRUG: GSK2879552|DRUG: ATRA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
Status: RECRUITING
Conditions: Intensive Care Unit Syndrome|Intensive Care Neuropathy|Intensive Care (ICU) Myopathy|Acute Respiratory Distress Syndrome|Cardiac Failure|Respiratory Failure|Critical Illness Myopathy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Does Treatment With GLP-1 Reduce Alcohol Intake in Patients With Alcohol Dependence?
Status: COMPLETED
Conditions: Alcohol Dependence, in Remission|Addiction, Alcohol
Interventions: DRUG: Exenatide 2 MG Injection|DRUG: BD PosiFlush (saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Cardiac Autonomic Tone in Hemodialysis
Status: COMPLETED
Conditions: Cardiovascular Disease|Sudden Cardiac Death
Interventions: DIETARY_SUPPLEMENT: Alfacalcidol|DIETARY_SUPPLEMENT: Ergocalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rural Dementia Caregiver Project
Status: COMPLETED
Conditions: Depression|Stress, Psychological|Self Efficacy|Loneliness|Social Isolation|Health Care Utilization|Dementia|Dementia Alzheimers|Dementia of Alzheimer Type|Dementia, Vascular|Dementia Frontal|Dementia, Lewy Body|Dementia, Mixed|Dementia in Parkinsons Disease|Dementia, HIV|Dementia Frontotemporal|Dementia, Multi-Infarct
Interventions: BEHAVIORAL: Building Better Caregivers Workshop|BEHAVIORAL: Attention Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis
Status: TERMINATED
Conditions: Appendicitis
Interventions: DRUG: levofloxacin; metronidazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Oxytocin in Youth With Autism
Status: NOT_YET_RECRUITING
Conditions: Autism Spectrum Disorder
Interventions: DRUG: Oxytocin nasal spray|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM
Status: RECRUITING
Conditions: Fibrosis, Liver|Type 2 Diabetes Mellitus in Obese|Non-Alcoholic Fatty Liver Disease
Interventions: DRUG: Semaglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of an Anger and Stress Management Program on Reducing Blood Pressure Levels in Youth
Status: COMPLETED
Conditions: Cardiovascular Diseases|Hypertension
Interventions: BEHAVIORAL: Williams LifeSkills Stress and Anger Management Workshop|BEHAVIORAL: High school classes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Unilateral Stenting Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction
Status: COMPLETED
Conditions: Cholangiocarcinoma|Gallbladder Carcinoma|Hepatocellular Carcinoma
Interventions: DEVICE: biliary stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad
Status: COMPLETED
Conditions: Status Epilepticus
Interventions: DRUG: Levetiracetam|DRUG: Phenytoin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of Low-Dose Temozolomide During Whole Brain Radiation in Patients With Cerebral Metastases From Non-Small-Cell Lung Cancer (Study P04071)(TERMINATED)
Status: TERMINATED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Temozolomide and radiotherapy|PROCEDURE: Whole brain radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib-S-Malate in Treating Patients With Refractory Thyroid Cancer
Status: COMPLETED
Conditions: Poorly Differentiated Thyroid Gland Carcinoma|Recurrent Thyroid Gland Carcinoma|Stage I Thyroid Gland Follicular Carcinoma|Stage I Thyroid Gland Papillary Carcinoma|Stage II Thyroid Gland Follicular Carcinoma|Stage II Thyroid Gland Papillary Carcinoma|Stage III Thyroid Gland Follicular Carcinoma|Stage III Thyroid Gland Papillary Carcinoma|Stage IVA Thyroid Gland Follicular Carcinoma|Stage IVA Thyroid Gland Papillary Carcinoma|Stage IVB Thyroid Gland Follicular Carcinoma|Stage IVB Thyroid Gland Papillary Carcinoma|Stage IVC Thyroid Gland Follicular Carcinoma|Stage IVC Thyroid Gland Papillary Carcinoma|Tall Cell Variant Thyroid Gland Papillary Carcinoma|Thyroid Gland Oncocytic Follicular Carcinoma
Interventions: DRUG: Cabozantinib S-malate|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Implant Syndrome After EVAR and EVAS (INSPIRE Study)
Status: WITHDRAWN
Conditions: Abdominal Aortic Aneurysm|Inflammatory Response
Interventions: PROCEDURE: Endovascular Aneurysm Repair (EVAR)|PROCEDURE: Endovascular Aneurysm Sealing (EVAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Mechanical Vibration and Helfer Skin Tap Technique on Procedural Pain in Infants During Vaccination
Status: NOT_YET_RECRUITING
Conditions: Procedural Pain|Nursing Caries|Pain, Acute
Interventions: DEVICE: Mechanical vibration|BEHAVIORAL: Helfer skin tap technique (HSTT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly
Status: COMPLETED
Conditions: Virus Diseases|RNA Virus Infections|Respiratory Tract Diseases|Respiratory Tract Infections
Interventions: BIOLOGICAL: Quadrivalent VLP Vaccine|BIOLOGICAL: Fluarix Quadrivalent® Comparator Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Standard Root Planing vs. Periodontal Structure Repair Device for Treatment of Pockets Caused by Periodontal Disease
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DEVICE: Periodontal Structure Repair (PSR)|DEVICE: Standard Root Planing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stenting in the Treatment of Aneurysm Trial
Status: COMPLETED
Conditions: Intracranial Aneurysm
Interventions: DEVICE: endovascular coiling with any type of currently approved coil (first or second generation)|DEVICE: endovascular stenting with or without coiling. The stent may be any of the currently approved stents for intracranial aneurysms.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Subcutaneous Durvalumab in Patients With Non-Small Cell Lung Cancer and Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer|Small Cell Lung Cancer
Interventions: DRUG: Durvalumab|DRUG: Cisplatin|DRUG: Carboplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vaginal Rings
Status: COMPLETED
Conditions: Pregnancy
Interventions: DRUG: Estriol 0.400 mg/day and Trimegestone 0.06 mg/day|DRUG: Estriol 0.300 mg/day and Trimegestone 0.12 mg/day|DRUG: Estriol 0.200 mg/day and Trimegestone 0.18 mg/day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
Status: COMPLETED
Conditions: Chronic Rhinosinusitis|Nasal Polyps
Interventions: DRUG: placebo|DRUG: doxycycline 100 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine Versus the Combination of Trastuzumab Plus Docetaxel in Patients With HER2-positive Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Trastuzumab Emtansine|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Analyze the Efficacy of Acute Intake With a β-alanine Supplement in Recreational Cyclists
Status: COMPLETED
Conditions: Beta Alanine Supplementation
Interventions: DIETARY_SUPPLEMENT: Beta Alanine high dose|DIETARY_SUPPLEMENT: Beta Alanine low dose|DIETARY_SUPPLEMENT: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Intervening on Women's Health for Rural Young Breast Cancer Survivors
Status: RECRUITING
Conditions: Breast Cancer|Fertility|Contraception|Menopausal Symptoms
Interventions: BEHAVIORAL: Multi-component oncofertility care intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metabolic Effects of a Green Tea Extract in Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis, Relapsing-Remitting
Interventions: DIETARY_SUPPLEMENT: Capsules with 160 mg Teavigo (at least 94% EGCG)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Vitamin d and Omega 3 on Osteocalcin
Status: COMPLETED
Conditions: Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: vitamin D3|DIETARY_SUPPLEMENT: omega-3 fatty acid|DIETARY_SUPPLEMENT: vitamin D3 and omega-3 fatty acid|OTHER: control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of Copaxone Administered in Combination With Minocycline
Status: COMPLETED
Conditions: Relapse Remitting Multiple Sclerosis
Interventions: DRUG: glatiramer acetate with minocycline|DRUG: Glatiramer acetate with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Periprosthetic Distal Femur Fracture
Status: UNKNOWN
Conditions: Periprosthetic Fractures|Distal Femur Fractures
Interventions: PROCEDURE: Locked Compression Plating|PROCEDURE: Retrograde Intramedullary Nailing (RIMN)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Multi-professional Breathlessness Service for Patients With Breathlessness Due to Any Advanced Disease
Status: COMPLETED
Conditions: Breathlessness|COPD|Cancer|Chronic Heart Failure|Interstitial Lung Disease
Interventions: OTHER: Multi-professional breathlessness service (MBS)|OTHER: Delayed MBS Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62%
Status: COMPLETED
Conditions: Secondary Hypogonadism
Interventions: DRUG: Androxal 12.5 mg or 25 mg|DRUG: AndroGel 1.62%|DRUG: Placebo Capsules|DRUG: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Lower Extremities Cycling Functional Electrıcal Stimulation Training in Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Diplegic Cerebral Palsy
Interventions: OTHER: Cycling Functional Electrical Stimulation|OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Post Operative Endodontic Pain in Patients With Irreversible Pulpitis Treated With and Without Dexamethasone.
Status: NOT_YET_RECRUITING
Conditions: Pain
Interventions: DRUG: Dexamethasone 4mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Compare Early With Deferred Invasive Strategy for STEMI Presenting 24-48 Hours From Symptom Onset
Status: NOT_YET_RECRUITING
Conditions: ST-segment Elevation Myocardial Infarction (STEMI)
Interventions: PROCEDURE: Deferred invasive strategy|PROCEDURE: Early invasive strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Creatine Supplementation in Chronic Fatigue Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Fatigue Syndrome
Interventions: DIETARY_SUPPLEMENT: Creatine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced Constipation
Status: COMPLETED
Conditions: Opioid Induced Constipation
Interventions: DRUG: Polyethylene Glycol 3350|DRUG: Movantik
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AST-120 in Mild to Moderate Crohn's Patients With Fistulas
Status: COMPLETED
Conditions: Inflammatory Bowel Disease|Intestinal Fistula
Interventions: DRUG: AST-120
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Articaine 4% Versus Lidocaine 2% for Local Anesthesia of MIH-affected Maxillary Molars
Status: COMPLETED
Conditions: Molar Incisor Hypomineralisation
Interventions: DRUG: Lidocaine 2%|DRUG: Articaine 4%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lung Function Outcomes Following Removal of Airway Mucus Plugs in Patients With Asthma (FOCUS)
Status: RECRUITING
Conditions: Asthma
Interventions: PROCEDURE: Therapeutic bronchoscopy for removal of mucus plugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Auricular Vagus Nerve Stimulation
Status: RECRUITING
Conditions: Being in the 18-50 Age Population|Being Diagnosed With Frozen Shoulder by a Specialist Physician|Volunteer to Participate in the Study
Interventions: DEVICE: vagus nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: mACTonHEALTH: Psychological Flexibility and Activity Tracker - Protocol
Status: RECRUITING
Conditions: Health Behavior
Interventions: BEHAVIORAL: ACT-Based Intervention and Activity Tracker WITH Feedback|BEHAVIORAL: Gold Standard Intervention + Activity Tracker WITHOUT Feedback|BEHAVIORAL: Gold Standard Intervention and Activity Tracker WITH Feedback|BEHAVIORAL: ACT-Based Intervention and Activity Tracker WITHOUT Feedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: fMRI and Ghlrein in Obesity and Binge Eating Disorder
Status: COMPLETED
Conditions: Obesity|Binge Eating Disorder
Interventions: DIETARY_SUPPLEMENT: Fed Condition|DIETARY_SUPPLEMENT: Fasted condition|PROCEDURE: Blood samples|BEHAVIORAL: Subjective appetite ratings|PROCEDURE: fMRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Watch the Spot Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Solitary Pulmonary Nodule|Coin Lesion, Pulmonary|Lung Neoplasms|Carcinoma, Non-small-cell Lung
Interventions: OTHER: More Frequent Surveillance Strategy|OTHER: Less Frequent Surveillance Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exploratory Study of Precise Therapy for Advanced Tumor Patients With Malignant Hydrothorax or Ascites by Using PTC Drug Sensitivity Testing
Status: RECRUITING
Conditions: Lung Cancer|Breast Cancer|Gastric Cancer|Colorectal Cancer
Interventions: DIAGNOSTIC_TEST: Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Bexagliflozin Compared to Sitagliptin as Add-on Therapy to Metformin in Type 2 Diabetes Subjects
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Bexagliflozin|DRUG: Sitagliptin|DRUG: Placebo for sitagliptin|DRUG: Placebo for bexagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BRCA1/2 and Effect of Mifepristone on the Breast
Status: COMPLETED
Conditions: Women With Mutations in the Breast Cancer Susceptibility Genes BRCA1,2
Interventions: DRUG: Mifepristone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pain Control in Pediatric Oncology: Utility of EMLA Cream vs Lidocaine Injection in Lumbar Punctures
Status: COMPLETED
Conditions: Leukemia-Lymphoma
Interventions: DRUG: EMLA|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ticagrelor Versus Clopidogrel in Myocardial Salvage in Patients With STEMI Undergoing Primary PCI
Status: UNKNOWN
Conditions: Acute Coronary Syndrome
Interventions: DRUG: Ticagrelor|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Randomised Controlled Trial of Efficacy of Resistant Maltodextrins on Reducing Colonic Transit Time
Status: COMPLETED
Conditions: Constipation
Interventions: DIETARY_SUPPLEMENT: Resistant maltodextrins|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Endo-Laparoscopic Approach Versus Conventional Open Surgery in Obstructing Left-sided Colon Cancer: RCT
Status: COMPLETED
Conditions: Colonic Neoplasms
Interventions: PROCEDURE: endo-laparoscopic approach|PROCEDURE: open approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Yang Yin Fu Zheng Jie Du Therapy in HBV Associated Hepatocellular Carcinoma Based on the Platelet Count/Splenic Length-Diameter Ratio
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Yang Yin Fu Zheng Jie Du therapy|DRUG: Routine medical care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmethylphenidate Hydrochloride Tablets Under Fasting Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Dexmethylphenidate Hydrochloride|DRUG: Dexmethylphenidate Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Solid Tumors
Status: ACTIVE_NOT_RECRUITING
Conditions: Solid Tumors
Interventions: PROCEDURE: Production of Genetically-modified T cells|DRUG: Cyclophosphamide|DEVICE: IP Catheter Insertion|GENETIC: Infusion of 4H11-28z/fIL-12/EGFRt+ Genetically-modified T cells|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Document Long-Term Safety and Continued Benefit of Irinotecan and Carboplatin or Irinotecan in Subjects With Refractory Solid Tumors (Rollover Study -001, -002)
Status: COMPLETED
Conditions: Pediatric Solid Tumors
Interventions: DRUG: Carboplatin|DRUG: Irinotecan|DRUG: Irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Vitamin D Supplementation on Glutathione Peroxidase (GPx) Activity, Interleukin-6 (IL-6) Levels and Clinical Outcomes in Post-COVID-19 Patients
Status: COMPLETED
Conditions: Post-COVID19 Condition
Interventions: DRUG: vitamin D (cholecalciferol) supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: L. Plantarum 299v and Gut Microbiome, Diarrhoea, and Clostridioides Difficile Infection in Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colorectal Cancer|Clostridioides Difficile Infection|Diarrhea
Interventions: DIETARY_SUPPLEMENT: Sanprobi IBS®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prenatal Iron Supplements: Safety and Efficacy in Tanzania
Status: COMPLETED
Conditions: Malaria|Anemia
Interventions: DIETARY_SUPPLEMENT: Iron|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Nutrilite All-plant Protein Booster to Improve Sarcopenia and Osteoarthritis in Middle-aged and Elderly People
Status: NOT_YET_RECRUITING
Conditions: Osteoarthritis|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: All-plant Protein Booster Product Group|DIETARY_SUPPLEMENT: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Venous Cannulation Pain to Guide Choice of Anesthetic Method
Status: RECRUITING
Conditions: Pain, Postoperative|Pain Prediction|Laparoscopic Surgery|Venous Cannulation Pain|Anesthesia Opioid Free
Interventions: PROCEDURE: High-pain multimodal anesthesia with opioids|PROCEDURE: Low-pain opioid free|PROCEDURE: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome|Vitamin D Deficiency
Interventions: DRUG: Vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of PNF Patterns Training on Trunk Balance, and Gait in Chronic Stroke Patients
Status: COMPLETED
Conditions: Stroke, Ischemic
Interventions: OTHER: diagonal pattern training|OTHER: single plane training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diet-induced Thermogenesis in Patients With Postoperative Roux-in-Y Gastric Bypass (RYGBP) Weight Regain
Status: COMPLETED
Conditions: Obesity|Bariatric Surgery Candidate|Protein-energy; Imbalance
Interventions: OTHER: patients eat a mixed solid meal
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: NYU Langone Health Headache Center Learning Migraine Self-Management Techniques Study
Status: RECRUITING
Conditions: Migraine
Interventions: BEHAVIORAL: RELAXaHEAD Smartphone App|BEHAVIORAL: In-Person Training|BEHAVIORAL: Virtual Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DEVICE: Transcranial Direct Current Stimulation|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Empathy and Standard Diagnostic Procedures in an Outpatient Breast Clinic Might Not be Enough
Status: COMPLETED
Conditions: Anxiety
Interventions: OTHER: no intervention|BEHAVIORAL: delivery of a take-home brochure|BEHAVIORAL: patient care by a psychologically trained physician
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE