pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparing the Efficacy of a Dual-Frequency LLLT Device With a Sham Device as a Therapy for Adipose Tissue Loss
Status: COMPLETED
Conditions: Obesity|Body Weight|Fat Burn|Cellulite|Abdominal Fat|Adipose Tissue Atrophy
Interventions: DEVICE: Care as Usual Group|DEVICE: Sham Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Late-life Anxiety in Primary Care Settings
Status: COMPLETED
Conditions: Generalized Anxiety Disorder|Panic Disorder|Anxiety Disorder Not Otherwise Specified
Interventions: BEHAVIORAL: Cognitive behavioral therapy|BEHAVIORAL: Enhanced usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Metformin and Glimepiride (Low Dosage)|DRUG: Metformin and Vildagliptin (Low Dosage)|DRUG: Metformin and Insulin Glargine U100 (Low Dosage)|DRUG: Metformin, Insulin Glargine U100, and Human Regular Insulin (Low Dosage)|DRUG: Metformin and Glimepiride (Regular Dosage)|DRUG: Metformin and Vildagliptin (Regular Dosage)|DRUG: Metformin and Insulin Glargine U100 (Regular Dosage)|DRUG: Metformin, Insulin Glargine U100, and Human Regular Insulin (Regular Dosage)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Cardiac Disease|Cardiac Failure|Cardiac Surgery|Inotropes|Ejection Fraction
Interventions: PROCEDURE: preoperative infusion of levosimendan|PROCEDURE: no preoperative infusion of levosimendan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: School-Based Intervention Program to Promote Healthy Eating and Physical Activity
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Childhood|Health Behavior|Physical Activity|Dietary Habits
Interventions: BEHAVIORAL: Intervention Program to Promote Healthy Eating and Physical Activity among Palestinian Female Schoolchildren
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparing the Incidence of Preeclampsia Between Pregnant Women Receiving Tdap Vaccinations at Week 28 or at Week 36
Status: NOT_YET_RECRUITING
Conditions: Pre-Eclampsia|Diphtheria, Tetanus and Pertussis Vaccine Reaction
Interventions: DRUG: Tdap Vaccine Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: RFA or Surgical Resection Combined With Neo-MASCT for Primary HCC: a Phase II Trial
Status: UNKNOWN
Conditions: Primary Liver Cancer|Radiofrequency Ablation|Immunotherapy|Hepatectomy
Interventions: BIOLOGICAL: Neo-MASCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients
Status: UNKNOWN
Conditions: Postoperative Confusion
Interventions: DRUG: Induction of anesthesia,midazolam ,sufentanil,etomidate and rocuronium|DRUG: Dexmedetomidine|DRUG: Normal saline|DRUG: Maintenance of anesthesia , propofol, remifentanil,vecuronium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Study of TS-142 in Healthy Participants (Single Doses)
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Placebo (fasting)|DRUG: Placebo (feeding)|DRUG: 1 mg of TS-142|DRUG: 3 mg of TS-142|DRUG: 10 mg of TS-142 (fasting)|DRUG: 10 mg of TS-142 (feeding)|DRUG: 30 mg of TS-142
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety, Tolerability, and Immunogenicity of an Investigational Zoster Vaccine In Subjects With a History of Varicella (Chickenpox)(V211-010)(COMPLETED)
Status: COMPLETED
Conditions: Herpes Zoster
Interventions: BIOLOGICAL: Comparator: zoster vaccine live (Oka/Merck) refrigerated formulation|BIOLOGICAL: Comparator: zoster vaccine live (Oka/Merck) frozen formulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ZEN003694 Combined With Niraparib in Patients With Metastatic or Recurrent Solid Tumors
Status: RECRUITING
Conditions: Ovarian Cancer|Recurrent Solid Tumors
Interventions: DRUG: ZEN003694|DRUG: Niraparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Trail of Adjuvant Chemoradiotherapy Versus Adjuvant Radiotherapy in Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Esophageal Cancer
Interventions: RADIATION: Adjuvant radiotherapy|RADIATION: Adjuvant radiotherapy|DRUG: Paclitaxel and carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Domiciliary Use of Hyaluronic Acid Gel Solutions vs Domiciliary Use of Chlorhexidine Mouthwash 0,20% for the Management of Peri-implant Mucositis Sites
Status: COMPLETED
Conditions: Peri-implant Mucositis
Interventions: OTHER: Aftoral Oral Gel|OTHER: Unidea Chlorhexidine mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of XY03-EA Tablets in the Treatment of Acute Ischemic Stroke
Status: ENROLLING_BY_INVITATION
Conditions: Acute Ischemic Stroke
Interventions: DRUG: XY03-EA|DRUG: XY03-EA Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Chlorella Supplementation on Running Performance
Status: RECRUITING
Conditions: Athletes|Healthy
Interventions: DIETARY_SUPPLEMENT: Chlorella supplementation|DIETARY_SUPPLEMENT: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oral Vancomycin for Preventing Clostridium Difficile Recurrence
Status: TERMINATED
Conditions: Clostridium Difficile Infection
Interventions: DRUG: Oral Vancomycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Efficacy Study of PI-88 With Docetaxel to Treat Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: PI-88|DRUG: docetaxel|DRUG: prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexlansoprazole on Bone Homeostasis
Status: COMPLETED
Conditions: Homeostasis|Bone and Bones
Interventions: DRUG: Dexlansoprazole|DRUG: Esomeprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning
Status: COMPLETED
Conditions: Insulin|Glucose Metabolism
Interventions: DIETARY_SUPPLEMENT: low feeding frequency (3x)|DIETARY_SUPPLEMENT: High feeding frequency (14x)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug Interaction & Methadone & Buprenorphine
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Methadone|DRUG: DCV 3DAA FDC|DRUG: BMS-791325|DRUG: Buprenorphine|DRUG: Naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Using Digital Health, Financial Incentives, and Community Health Worker Support to Change Health Behavior
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: IMPaCT Community Health Worker|BEHAVIORAL: Digital health monitoring with financial incentives|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy and Safety of Using MPC-5971 in Subjects Undergoing Shock Wave Lithotripsy
Status: TERMINATED
Conditions: Nephrolithiasis
Interventions: OTHER: placebo|DRUG: MPC-5971
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Lumacaftor in Combination With Ivacaftor in Subjects With Moderate Hepatic Impairment and Healthy Subjects
Status: COMPLETED
Conditions: Hepatic Impairment|Healthy
Interventions: DRUG: lumacaftor 200 mg q12h + ivacaftor 250 mg q12h
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism
Status: COMPLETED
Conditions: Venous Thrombosis
Interventions: DRUG: Apixaban|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gait Analysis and Neuromuscular Function After Primary Total Hip Replacement
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: Articular Surface Replacement (ASR)|PROCEDURE: Standard Total Hip Arthroplasty (THA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dapagliflozin in Respiratory Failure in Patients With COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Dapagliflozin 10 milligram (mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Clinical Trial to Assess the Effectiveness of Pharmaceutical Intervention in Patients With Uncontrolled Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: BEHAVIORAL: pharmaceutical intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Everolimus, Bortezomib and/or Rituximab in Patients With Relapsed/Refractory Waldenstrom's Macroglobulinemia
Status: TERMINATED
Conditions: Waldenstrom's Macroglobulinemia
Interventions: DRUG: Everolimus|DRUG: Rituximab|DRUG: Bortezomib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Safety of a New Influenza Vaccine
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Monovalent Frozen FluMist®|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping
Status: COMPLETED
Conditions: Cerebral Infarction
Interventions: DRUG: Triflusal|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Registry of Emergent Large veSsel oCclUsion duE to IntraCranial AtherosclerosiS
Status: ACTIVE_NOT_RECRUITING
Conditions: Intracranial Stenosis|Large Vessel Occlusion|Mechanical Thrombectomy
Interventions: OTHER: No Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Evaluation of Safety of the Fentanyl Transdermal System for Management of Acute Post-Operative Pain in Pediatric Patients
Status: WITHDRAWN
Conditions: Pain, Postoperative|Pediatrics
Interventions: DRUG: fentanyl iontophoretic transdermal system (40mcg) No placebo|DRUG: fentanyl iontophoretic transdermal system (40mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of an Early Parenting Intervention for Children With Genetic Abnormalities and Mental Health Problems
Status: RECRUITING
Conditions: Genetic Syndrome|Language Development|Autism or Autistic Traits|Parenting
Interventions: BEHAVIORAL: Incredible Years Autism Spectrum and Language Delays Parent Program (IY-ASLD®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromodulatory Effects of Transcranial Pulsed Current Stimulation in Fibromyalgia
Status: UNKNOWN
Conditions: Fibromyalgia
Interventions: DEVICE: Transcranial Pulsed Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Panoramic Screening by Complete Colonoscopy in the Management of Colorectal Adenomas
Status: COMPLETED
Conditions: Colorectal Adenoma
Interventions: DEVICE: G-EYE first and standard colonoscope|DEVICE: standard colonoscope first and G-EYE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2 Application Techniques for LET Gel Used Prior to Simple Laceration Repair
Status: COMPLETED
Conditions: LET|Laceration of Skin
Interventions: DRUG: LET (lidocaine 4%; epinephrine 0.1%; tetracaine 0.5%) gel (1 application)|DRUG: LET (lidocaine 4%; epinephrine 0.1%; tetracaine 0.5%) gel (3 applications)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Iodine-131 Anti-B1 Antibody for the Retreatment of Patients With Non-Hodgkin's Lymphoma
Status: UNKNOWN
Conditions: Non-Hodgkin's Lymphoma
Interventions: DRUG: Iodine-131 Anti-B1 Antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase Ib/II Study Evaluating Orteronel (Without Prednisone) Combined With Itraconazole In Men With Castration-Resistant Prostate Cancer (CRPC)
Status: WITHDRAWN
Conditions: Prostate Cancer|Castration-resistant Prostate Cancer
Interventions: DRUG: Itraconazole|DRUG: Orteronel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: Ozanimod|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Almorexant (ACT-078573) in Elderly Subjects With Chronic Primary Insomnia
Status: COMPLETED
Conditions: Chronic Primary Insomnia
Interventions: DRUG: ACT-078573 oral capsules at 25 and 100 mg and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo|DRUG: ACT-078573 and matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IGF-I Induced Muscle Glucose Uptake and Interstitial IGF-I Concentrations
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Increlex|DRUG: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antidepressant Response in Older Adults With Comorbid PTSD and MDD
Status: TERMINATED
Conditions: Post Traumatic Stress Disorder|Major Depressive Disorder
Interventions: DRUG: Escitalopram|DRUG: Duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clofarabine, Cytarabine and Mitoxantrone (CLAM) for Relapsed or Refractory AML
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Clofarabine, AraC, mitoxantrone (CLAM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Infant Malnutrition|Malnutrition in Pregnancy
Interventions: DIETARY_SUPPLEMENT: IFA|DIETARY_SUPPLEMENT: MMN|DIETARY_SUPPLEMENT: LNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
Status: COMPLETED
Conditions: Cognitive Aging
Interventions: DRUG: Guanfacine|DRUG: Guanfacine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rescue Fecal Microbiota Transplantation for National Refractory Intestinal Infections
Status: RECRUITING
Conditions: Intestinal Infection|Clostridioides Difficile Infection|Antibiotic-associated Diarrhea
Interventions: OTHER: rescue fecal microbiota transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Parrying the Pitfalls of PrEP: Project PEACH
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV|STI
Interventions: BEHAVIORAL: PrEP discontinuation intervention|DRUG: Offering of on-demand oral PrEP|DRUG: Offering of STI PEP|DRUG: Injectable PrEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Estrogens Effect on Pain in Postmenopausal Women Suffering of Fibromyalgia
Status: TERMINATED
Conditions: Fibromyalgia
Interventions: DRUG: 17β-estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: SARS-CoV-2 and Influenza A/B in Point-of-Care and Non-Laboratory Settings
Status: RECRUITING
Conditions: SARS-CoV-2 Infection|Influenza A|Influenza B
Interventions: DIAGNOSTIC_TEST: Aptitude Medical Systems Metrix COVID/Flu Test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Assessing Dynamic Magnetic Resonance (MR) Imaging in Patients With Recurrent High Grade Glioma Receiving Chemotherapy
Status: TERMINATED
Conditions: Brain Neoplasms
Interventions: DRUG: Ferumoxytol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Mobile Application Robot Developed for Pediatric Diabetes Management on Children With Diabetes Mellitus
Status: RECRUITING
Conditions: Diabetes Mellitus, Type 1|Children|Adolescent
Interventions: BEHAVIORAL: DİABOT (mobile application robot )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects
Status: COMPLETED
Conditions: Aging|Mitochondrial Dysfunction|Muscle Function
Interventions: DIETARY_SUPPLEMENT: Mitopure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Alcohol PBS and Thinking About the Past
Status: COMPLETED
Conditions: Alcohol Drinking in College
Interventions: BEHAVIORAL: Negative Event + Counterfactual Task|BEHAVIORAL: Personalized Normative Feedback|BEHAVIORAL: Negative Event + Factual Thinking Task|BEHAVIORAL: Negative Event Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients.
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DIAGNOSTIC_TEST: Muscle strength and fatigue assessment|DIAGNOSTIC_TEST: Dual-energy X-ray absorptiometry (DEXA scan)|DIAGNOSTIC_TEST: Supine cardiorespiratory fitness assessment|DIAGNOSTIC_TEST: fMRI Exercise assessment|DIAGNOSTIC_TEST: Muscle deconditioning assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MMF Versus CYC in the Induction Therapy of Pediatric Active Proliferative LN
Status: RECRUITING
Conditions: Mycophenolate Mofetil|Cyclophosphamide|Lupus Nephritis
Interventions: DRUG: Cyclophosphamide|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
Status: NOT_YET_RECRUITING
Conditions: Mechanical Ventilator Weaning|Critically Ill|Mechanical Ventilation|Neurally Adjusted Ventilatory Assist
Interventions: PROCEDURE: NAVA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Imiquimod Cream Prior to Ablative Therapy in External Ano-Genital Warts
Status: COMPLETED
Conditions: Genital Warts
Interventions: DRUG: Imiquimod|OTHER: vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402)
Status: COMPLETED
Conditions: Leukemia, Myelocytic, Acute|Leukemia, Lymphocytic, Acute|Leukemia, Myeloid, Chronic|Myelodysplastic Syndromes
Interventions: DRUG: Tacrolimus|DRUG: Methotrexate|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: S9415 Chemotherapy in Patients With Stage II or III Colon Cancer That Has Been Surgically Removed
Status: COMPLETED
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: levamisole hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy and Imatinib Mesylate in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: GM-K562 cell vaccine|DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of MSD-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: RADIATION: TBI|RADIATION: TMLI|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-uterine Injection of Human Chorionic Gonadotrophin (hCG) Before Embryo Transfer
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: human chorionic gonadotrophin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Platelet Rich Plasma Drops to Moderate Clinically Significant Dry Eye
Status: NOT_YET_RECRUITING
Conditions: Dry Eye Syndromes
Interventions: OTHER: Platelet Poor Plasma Tear Drops|OTHER: Platelet Rich Plasma Tear Drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess Safety, Tolerability and Pharmacokinetics of Treamid in Healthy Volunteers
Status: COMPLETED
Conditions: Metabolic Syndrome
Interventions: DRUG: Treamid 5 mg|DRUG: Treamid 15 mg|DRUG: Treamid 50 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Targeted Self-Management for Epilepsy and Serious Mental Illness (TIME)
Status: COMPLETED
Conditions: Epilepsy|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Depression
Interventions: BEHAVIORAL: TIME
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of a Dietary Supplement on Lipid Pattern and Liver Parameters in Hypercholesterolemia
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DIETARY_SUPPLEMENT: Dietary supplement|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Split Face Study of the Effects of Micro Needling With and Without Platelet Rich Plasma
Status: TERMINATED
Conditions: Aging
Interventions: DEVICE: Microneedling w/ and w/o PRP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Usefulness of A Scope Guide Assisted Colonoscopy Versus Conventional Colonoscopy
Status: COMPLETED
Conditions: Colonoscopy, Colorectal
Interventions: PROCEDURE: Scope Guide Assist|PROCEDURE: Standard procedure for colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Prevention of C.Difficile Infections With Oral Vancomycine in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant
Status: NOT_YET_RECRUITING
Conditions: Clostridium Difficile Infections|Stem Cell Transplant Complications
Interventions: DRUG: Vancomycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Cognitive Behavioural Therapy (CBT) For Improving Emotional Well Being in Spinal Cord Injuries (SCI)
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: CBT|BEHAVIORAL: Waitlist CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Developing Strategies for Effective Debridement in Patients for Venous Leg Ulcers
Status: RECRUITING
Conditions: Venous Leg Ulcer
Interventions: PROCEDURE: Wound Edge Debridement|OTHER: Standard of Care Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: What Works to Get the Elderly Vaccinated Against COVID-19? Experimental Evidence From India
Status: COMPLETED
Conditions: Aging|Covid19
Interventions: BEHAVIORAL: Information|BEHAVIORAL: Buddy|BEHAVIORAL: Gossip intervention|BEHAVIORAL: Information assigned in community|BEHAVIORAL: Buddy assigned in community
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE
Status: TERMINATED
Conditions: Pulmonary Hypertension|Interstitial Lung Disease|Combined Pulmonary Fibrosis and Emphysema
Interventions: DRUG: Inhaled Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of Single Port Robot in Colorectal Procedures
Status: UNKNOWN
Conditions: Colon Cancer|Colon Polyp|Rectal Cancer|Diverticulitis|Prolapse, Rectal|Rectal Polyp|Inflammatory Bowel Diseases
Interventions: DEVICE: Single Port Robotic Colorectal Surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pediatric-type Therapy With Pre-transplant Blinatumomab for HR Patients - Phase II Study
Status: RECRUITING
Conditions: Philadelphia-Negative ALL|High-Risk Cancer
Interventions: DRUG: Blinatumomab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Mindfulness-Based Cognitive Therapy in the Treatment of Recurrent Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder, Recurrent
Interventions: BEHAVIORAL: MBCT|OTHER: TAU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With Pulmonary Arterial Hypertension (PAH)
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Riociguat (Adempas, BAY63-2521)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HOPE - A Study to Evaluate the Effect of a Prehabilitation Program on GI Cancer Patients Planning to Undergo Surgery
Status: UNKNOWN
Conditions: Pancreatic Cancer|Esophageal Cancer|Gastric Cancer
Interventions: COMBINATION_PRODUCT: Nutritional Intervention|BEHAVIORAL: Physical Activity Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ASP8374 + Cemiplimab in Recurrent Glioma
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma|Recurrent Glioblastoma
Interventions: DRUG: ASP8374|DRUG: cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Patients at Increased Risk for the Development of Ventilator-associated Pneumonia in the Intensive Care Unit
Status: UNKNOWN
Conditions: Biofilm Formation|Structural and Microbiological Characterization of Endotracheal Tube Biofilm|Ventilator-associated Pneumonia (VAP)
Interventions: BIOLOGICAL: microbiological characterization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Pegetron® Redipen™ Treatment and Treatment Compliance of Patients With Chronic Hepatitis C in Canada (P04423)
Status: COMPLETED
Conditions: Hepatitis C, Chronic|Hepatitis C
Interventions: BIOLOGICAL: PegIFN-2b|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Testing the Effectiveness of Henna on Managing PPE
Status: COMPLETED
Conditions: Palmar-plantar Erythrodysesthesia (PPE)
Interventions: DRUG: Henna|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Therapy of HAIC, Surufatinib and Tislelizumab for Unresectable or Metastatic Biliary Tract Cancer
Status: NOT_YET_RECRUITING
Conditions: Carcinoma|Intrahepatic Cholangiocarcinoma|Gallbladder Cancer|Surufatinib|Angiogenesis Inhibitors|Tislelizumab|Antineoplastic Agents, Immunological|Immunotherapy
Interventions: DRUG: HAIC|DRUG: Surufatinib|DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Red Clover Isoflavones in Postmenopausal Women With Urge Urinary Incontinence and Overactive Bladder
Status: COMPLETED
Conditions: Urge Incontinence|Overactive Bladder
Interventions: DIETARY_SUPPLEMENT: Red Clover Extract (RCE)|OTHER: Placebo (PL)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study in the Treatment of Children and Adolescents With Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: fluoxetine|DRUG: duloxetine|DRUG: duloxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Musicians United for Seniors to Improve Care (MUSIC) Study
Status: COMPLETED
Conditions: Music|Gait|Emotions|Communication
Interventions: BEHAVIORAL: Mood Assessment|BEHAVIORAL: Emotion Assessment|BEHAVIORAL: Communication Assessment|OTHER: Mobility assessment|OTHER: Music Intervention|OTHER: Documentary watching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Laparotomy Study
Status: COMPLETED
Conditions: Gastrointestinal Cancer
Interventions: DRUG: Group STANDARD: Rocuronium 0.6 mg/kg followed by bolus rocuronium according to standard treatment combined with saline infusion (placebo).|DRUG: Group DEEP: Rocuronium 0.6 mg/kg followed by rocuronium infusion with target level PTC 0-1 combined with bolus saline (placebo) mimicking standard treatment.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Paravertebral Block for Pain Management After Appendectomy
Status: UNKNOWN
Conditions: Reduce Pain After Appendectomy
Interventions: OTHER: PVB|OTHER: Placebo|OTHER: GA|OTHER: Anesthetic injections
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Safety of Cultured Autologous Adult Adipose Derived Mesenchymal Stem Cell Intrathecal Injection for SCI
Status: SUSPENDED
Conditions: Spinal Cord Injuries
Interventions: BIOLOGICAL: autologous adipose derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety of BMS-986259 in Participants With Post-Acute Decompensated Heart Failure
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: DRUG: BMS-986259|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage (OPTTTICH Feasibility Study)
Status: COMPLETED
Conditions: Traumatic Intracranial Haemorrhage
Interventions: DRUG: Enoxaparin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Rituximab Combined With Chemotherapy in Burkitt's Lymphoma
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Burkitt's Lymphoma
Interventions: DRUG: RITUXIMAB
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Lurbinectedin (PM01183)/Doxorubicin Versus CAV or Topotecan as Treatment in Patients With Small-Cell Lung Cancer
Status: COMPLETED
Conditions: Small-cell Lung Cancer
Interventions: DRUG: Lurbinectedin (PM01183)|DRUG: Doxorubicin (DOX)|DRUG: Cyclophosphamide (CTX)|DRUG: Vincristine (VCR)|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IC14 (Atibuclimab) in Arrhythmogenic Cardiomyopathy
Status: RECRUITING
Conditions: Arrhythmogenic Right Ventricular Dysplasia|Arrhythmogenic Left Ventricular Cardiomyopathy|Arrhythmogenic Right Ventricular Cardiomyopathy 1|Arrhythmogenic Cardiomyopathy
Interventions: BIOLOGICAL: IC14
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis
Status: RECRUITING
Conditions: Haemochromatosis
Interventions: OTHER: Clinical examination|OTHER: SF36 questionnaire|OTHER: AIMS2_SF questionnaire|OTHER: WOMAC questionnaire|OTHER: EQ-5D-5L questionnaire|BIOLOGICAL: Blood Sample Complete blood count|BIOLOGICAL: Blood Sample Iron panel|BIOLOGICAL: Blood Sample Fasting Glucose|BIOLOGICAL: Blood sample lipid panel|BIOLOGICAL: Blood sample liver panel|BIOLOGICAL: Blood sample C reactive protein|PROCEDURE: Bloodletting - control group|BIOLOGICAL: BioBank|OTHER: Medico-economical|PROCEDURE: Bloodletting - experimental group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imagio Feasibility Multi-Reader, Multi-Case Study
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DEVICE: Imagio (IUS+OA)|DEVICE: Imagio Ultrasound|DEVICE: Mammography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety and Efficacy Study of SL1904B CAR-T Cells for Relapsed or Refractory B-Cell Acute Lymphocyte Leukemia
Status: UNKNOWN
Conditions: B-ALL
Interventions: BIOLOGICAL: CD19 CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of CD19 Universal CAR-γδT Cells in Active Systemic Lupus Erythematosus
Status: RECRUITING
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: CD19 Universal CAR-γδ T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transfer to Improve Diabetes Control Post-bariatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Bariatric Surgery|Type 2 Diabetes
Interventions: DRUG: Capsulized fecal microbiota transfer containing the healthy feces + stool dilution solution|DRUG: Capsulized placebo transfer containing dilution solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Precise Intervention Technology and Application of Low Intensity TUS on Negative Symptoms of Schizophrenia
Status: NOT_YET_RECRUITING
Conditions: Negative Symptoms of Schizophrenia
Interventions: DEVICE: low-intensity transcranial ultrasound stimulation (TUS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ambu®AuraGain™ Versus I-gel® in Obese Patients
Status: COMPLETED
Conditions: Obese
Interventions: DEVICE: Ambu AuraGain|DEVICE: Intersurgical i-gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Measurement of Cardiac Output and Stroke Volume in PAH/CTEPH
Status: ENROLLING_BY_INVITATION
Conditions: Pulmonary Arterial Hypertension|Chronic Thromboembolic Pulmonary Hypertension
Interventions: DEVICE: Non-invasive hemodynamic measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Osteoporosis and Dental Implant
Status: UNKNOWN
Conditions: Osteoporosis
Interventions: DRUG: alendronate once weekly 70mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Sulphate to Bupivicaine in Serratus Anterior Plane Block in Modified Radical Mastectomy
Status: UNKNOWN
Conditions: Cancer Breast|Chronic Pain Syndrome
Interventions: DRUG: magnesium sulphate|DRUG: bupivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS)
Status: COMPLETED
Conditions: Amyotrophic Lateral Sclerosis
Interventions: DEVICE: BiPAP® S/T System|OTHER: sham-NIPPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hormonal Contraception in Healthy Young Men (P42306)(COMPLETED)(P06057)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: etonogestrel with testosterone undecanoate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Macroscopic and Molecular Changes in Knee Muscular - Tendon Unit in Response to Acute Resistant Load
Status: UNKNOWN
Conditions: Physical Exertion
Interventions: OTHER: Exercise|OTHER: No exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects
Status: COMPLETED
Conditions: Smallpox
Interventions: BIOLOGICAL: IMVAMUNE|BIOLOGICAL: IMVAMUNE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Regorafenib Plus PD-1 Inhibitor in Patients With Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer|Immunotherapy
Interventions: DRUG: Regorafenib and PD-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RCT of TeachTown in Autism Support Classrooms: Innovation and Exnovation
Status: COMPLETED
Conditions: Autism Spectrum Disorder
Interventions: BEHAVIORAL: TeachTown|BEHAVIORAL: Discrete Trial Training|BEHAVIORAL: Pivotal Response Training|BEHAVIORAL: Teaching in Functional Routines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Combination of Proximal ACB and iPACK With Large-Volume Distal ACB for Early Mobilization After TKR
Status: COMPLETED
Conditions: Adductor Canal Block|Postoperative Pain|Regional Anesthesia
Interventions: PROCEDURE: Regional Anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intentional Pulpotomy to Preserve Hopeless Molars
Status: COMPLETED
Conditions: Pulpitis|Dental Pulp Diseases|Tooth Diseases
Interventions: PROCEDURE: Pulpotomy|PROCEDURE: Extraction and placement of space maintainer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Novel Sequential Treatment of Salvage and Reduced Intensity Conditioning (RIC) Chemotherapy for Allogeneic Stem-Cell Transplantation (SCT) for Primary Refractory and Relapsed Acute Myelogenous Leukemia (AML)
Status: COMPLETED
Conditions: Acute Myelogenous Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)
Status: RECRUITING
Conditions: Asthma and/or Exercise Induced Bronchoconstriction|Ozone Air Pollution
Interventions: DRUG: Salbutamol|DRUG: Placebo medication|OTHER: Ozone|OTHER: Filtered Air|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Phase III Trial Treosulfan-based Conditioning Versus Reduced-intensity Conditioning (RIC)
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: DRUG: Busulfan|DRUG: Treosulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of 23-valent Pneumococcal Polysaccharide Vaccine
Status: COMPLETED
Conditions: Pneumococcal Infections
Interventions: BIOLOGICAL: Experimental 23-valent PPV|BIOLOGICAL: Control 23-valent PPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION