pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Comparable Investigation of One Fraction Radiotherapy and Multifraction Radiotherapy in Patients With Multiple Myeloma.
Status: UNKNOWN
Conditions: Multiple Myeloma and Malignant Plasma Cell Neoplasms
Interventions: RADIATION: External Beam radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Trial of Zavegepant* Intranasal for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen
Status: TERMINATED
Conditions: COVID-19 Infection
Interventions: DRUG: Zavegepant (BHV-3500)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the PTH-independent Effects of Encaleret on Mineral Homeostasis in Subjects With Postsurgical Hypoparathyroidism (PSH)
Status: RECRUITING
Conditions: Post-Surgical Hypoparathyroidism
Interventions: DRUG: encaleret
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Stereotactic Radiation Therapy in Treating Patients With Prostate Cancer
Status: TERMINATED
Conditions: Prostate Cancer
Interventions: OTHER: questionnaire administration|PROCEDURE: implanted fiducial-based imaging|RADIATION: stereotactic radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI)
Status: COMPLETED
Conditions: Lower Respiratory Tract Infection|Acute Bronchitis|Pneumonia|Chronic Obstructive Pulmonary Disease (COPD)|Upper Respiratory Tract Infection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of DWP14012 After Oral Administration in Healthy Japanese, Caucasian and Korean
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DWP14012|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Chronic Fatigue Syndrome (CFS) With Iodinated Activated Charcoal (IodoCarb®)
Status: UNKNOWN
Conditions: Chronic Fatigue Syndrome
Interventions: DRUG: IodoCarb (r)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine, Carboplatin or Paclitaxel Plus Radiation Therapy in Treating Patients With Stage IIIA or IIIB Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: carboplatin|DRUG: gemcitabine hydrochloride|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous (SC) Administered Alirocumab in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: alirocumab SAR236553 (REGN727)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: V114 and Acute Otitis Media (V114-032/PNEU-ERA)
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Otitis Media (AOM)
Interventions: BIOLOGICAL: V114|OTHER: Pediatric vaccines
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PK/PD Study of 2 Agalsidase Formulations in Single Dose of 1 mg/kg Administered to Healthy Volunteers as IV Infusion
Status: COMPLETED
Conditions: Fabry Disease
Interventions: BIOLOGICAL: Agalsidase beta from Biosidus 1 mg/kg|BIOLOGICAL: Fabrazyme (agalsidase beta) 1 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Increasing Doses of BIII 890 CL in Healthy Young Male Volunteers and in Healthy Elderly Male and Female Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIII 890 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Cytokine-induced Memory-like NK Cells in Relapsed/Refractory AML and MDS
Status: WITHDRAWN
Conditions: Relapsed Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: BIOLOGICAL: Cytokine-induced memory-like NK cells|DRUG: Fludarabine|DRUG: Cyclophosphamide|PROCEDURE: Donor Leukapheresis|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Gemcitabine for Treatment Resistant Patients With Metastatic Colorectal Cancer and KRAS Mutations
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Pemetrexed|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Proprioceptive Neuromuscular Facilitation Exercises in Patients With Myasthenia Gravis
Status: RECRUITING
Conditions: Myasthenia Gravis
Interventions: OTHER: proprioceptive neuromuscular facilitation exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Two Different Exercise Practices on Maximum Oxygen Uptake and Pulmonary Function
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Core exercises|OTHER: Auxiliary respiratory exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: AML96 - Risk-Adapted and Randomized Postremission-Therapy for Adult Acute Myeloid Leukemia Patients
Status: COMPLETED
Conditions: Leukemia, Nonlymphoblastic, Acute
Interventions: DRUG: Cytarabine Dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Long-Term Cognitive Decline After Coronary Artery Bypass Grafting: is Off-Pump Surgery Beneficial?
Status: COMPLETED
Conditions: Coronary Artery Disease|Cardiopulmonary Bypass|Cognition Disorders
Interventions: DEVICE: cardiac stabilizer instead of cardiopulmonary bypass
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Compassion Focused Therapy (CFT)
Status: TERMINATED
Conditions: Compassion|Self-Criticism|Shame|Guilt
Interventions: BEHAVIORAL: Treatment as Usual|BEHAVIORAL: Compassion-Focused Therapy (CFT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and/or Sunitinib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IIIB Non-Small Cell Lung Cancer AJCC v7|Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Pemetrexed Disodium|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of PKs of 17-Beta-Estradiol Via Sublingual Placement Versus Swallowing in Male-to-Female Transgender Patients
Status: TERMINATED
Conditions: Gender Dysphoria
Interventions: DRUG: 17beta Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Intravenous Aflibercept With Docetaxel in Chinese Patients With Solid Tumors
Status: COMPLETED
Conditions: Neoplasm Malignant
Interventions: DRUG: Aflibercept (AVE0005)|DRUG: Docetaxel (XRP6976)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3
Status: TERMINATED
Conditions: Stroke, Acute|Cerebral Infarction
Interventions: PROCEDURE: Endovascular Thrombectomy|DEVICE: Trevo Retriever|DEVICE: Solitaire™ FR Revascularization Device|DEVICE: Penumbra thrombectomy system|DEVICE: Covidien MindFrame Capture Revascularization Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of the Panbio™ COVID-19/Flu A&B Rapid Panel Professional Use Device and the Panbio™ COVID-19/Flu A&B Rapid Panel Self-Test Device
Status: COMPLETED
Conditions: COVID-19|Influenza A|Influenza Type B
Interventions: DIAGNOSTIC_TEST: Panbio™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Outcomes of Cyclosporine Eye Drops in Management of Herpetic Keratitis
Status: COMPLETED
Conditions: Outcomes of Cyclosporine Eye Drops in Herpetic Keratitis
Interventions: DRUG: cyclosporine A 0.05% eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Paclitaxel/Carboplatin and Lonafarnib to Paclitaxel/Carboplatin for First-line Treatment of Ovarian Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer
Interventions: DRUG: Lonafarnib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis
Status: TERMINATED
Conditions: Non-infectious Uveitis
Interventions: BIOLOGICAL: AIN457|BIOLOGICAL: AIN457|BIOLOGICAL: AIN457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Granuloma Umbilical in Newborn Babies
Status: COMPLETED
Conditions: Fetus or Newborn Affected by Condition of Umbilical Cord
Interventions: PROCEDURE: silver nitrate|DRUG: Steroids|PROCEDURE: alcohol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motivational Counseling in Preventing Smoking Relapse After Pregnancy in Pregnant Women Who Quit Smoking During Pregnancy
Status: COMPLETED
Conditions: Bladder Cancer|Cervical Cancer|Esophageal Cancer|Gastric Cancer|Head and Neck Cancer|Kidney Cancer|Leukemia|Liver Cancer|Lung Cancer|Pancreatic Cancer|Tobacco Use Disorder
Interventions: BEHAVIORAL: Smoking Prevention Usual Care|BEHAVIORAL: Counseling Intervention|BEHAVIORAL: Counseling Intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia (ALL)|Acute Myeloid Leukemia (AML)|Myeloid Sarcoma|Chronic Myeloid Leukemia (CML)|Juvenile Myelomonocytic Leukemia (JMML)|Myelodysplastic Syndrome (MDS)|Non-Hodgkin Lymphoma (NHL)
Interventions: DRUG: Anti-thymocyte globulin (rabbit)|DRUG: Blinatumomab|DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: G-CSF|DRUG: Melphalan|DRUG: Mesna|DRUG: Rituximab|DRUG: Tacrolimus|DRUG: Thiotepa|BIOLOGICAL: HPC,A Infusion|DEVICE: CliniMACS|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modeling Cancer-specific Prognosis in Liver Transplantation for Hepatocellular Carcinoma (HCC)
Status: COMPLETED
Conditions: HCC|Liver Transplantation|Alphafetoprotein|Mortality|Competing Risk|Selection Criteria|Cancer Recurrence
Interventions: PROCEDURE: Liver transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness
Status: NOT_YET_RECRUITING
Conditions: Soil-Transmitted Helminths
Interventions: DRUG: Pre-screening Phase|DRUG: Screenig Phase|DRUG: Randomization|DRUG: Baseline Effectiveness Cohort|DRUG: Day 0 Trial Intervention|DRUG: Active Surveillance (study visit Day 1, Day 2 and Day 7)|DRUG: Passive Surveillance|DRUG: Post-Treatment Effectiveness Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: Reproxalap Ophthalmic Solution (0.25%)|DRUG: Reproxalap Ophthalmic Solution (0.1%)|DRUG: Vehicle Ophthalmic Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: fianlimab|DRUG: cemiplimab|DRUG: Pemetrexed|DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temsirolimus and Cixutumumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Soft Tissue Sarcoma or Bone Sarcoma
Status: COMPLETED
Conditions: Metastatic Osteosarcoma|Recurrent Adult Soft Tissue Sarcoma|Recurrent Osteosarcoma|Stage III Adult Soft Tissue Sarcoma|Stage IV Adult Soft Tissue Sarcoma
Interventions: BIOLOGICAL: Cixutumumab|OTHER: Laboratory Biomarker Analysis|DRUG: Temsirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erector Spinae Plane Block for Post-thoracotomy Pain
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: PROCEDURE: erector spinae plane block with ropivacaine|PROCEDURE: Intercostal nerve block with ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Flow Rates of HHHFNC to Prevent Extubation Failure in Preterm Infants
Status: COMPLETED
Conditions: Prematurity, Mechanical Ventilation
Interventions: DEVICE: HHHFNC 6 liter minute|DEVICE: HHHFNC 3 liters/min
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia
Status: SUSPENDED
Conditions: Dyskinesias|Movement Disorders|Central Nervous System Diseases|Nervous System Diseases|Neurologic Manifestations
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hyper-ERAS Program for Highly Selective Colorectal Cancer Patients
Status: RECRUITING
Conditions: Colorectal Cancer|ERAS
Interventions: PROCEDURE: Hyper-ERAS Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Mid- and Long-term Evaluation of the Results of Patients Undergoing Spinal Cord Stimulation With Microfractures + BST CarGel in the Treatment of Patellofemoral Chondral Lesions of the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Chondral Lesion of the Knee|Patellofemoral Disorder
Interventions: OTHER: survey
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Comparison Between the Exoskeleton Hybrid Assistive Limb and Conventional Gait Training Early After Stroke
Status: COMPLETED
Conditions: Stroke|Gait, Hemiplegic|Ambulation Difficulty|Hemiparesis
Interventions: DEVICE: Hybrid Assistive Limb (HAL); gait training|OTHER: Control Group; Conventional gait training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transition From Acute to Chronic Back Pain : Effect of L-dopa,Gender,and Associated Brain Plasticity
Status: WITHDRAWN
Conditions: Chronic Back Pain
Interventions: DRUG: carbidopa/levodopa and celecoxib|DRUG: placebo1 and celecoxib|DRUG: placebo1 and placebo2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decreasing Stress in Diabetes
Status: RECRUITING
Conditions: Stress|Diabetes Mellitus, Type 2|Diabetes Mellitus, Type 1
Interventions: BEHAVIORAL: Mindfulness Based Stress Reduction|BEHAVIORAL: Stress Management Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of BI 207127 + Faldaprevir on Blood Levels of Oral Contraceptives Containing Ethinylestradiol and Levonorgestrel
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: faldaprevir|DRUG: Microgynon®|DRUG: BI 207127
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm^2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DRUG: Rivastigmine 5 cm^2|DRUG: Rivastigmine 10 cm^2|DRUG: Rivastigmine 15 cm^2|DRUG: Placebo to 15 cm^2 patch|DRUG: Placebo to 10 cm^2 patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study to Evaluate the Efficacy and Safety of Omega-3-acids Ethylesters 90 in Type Ⅱb Hyperlipidemia
Status: UNKNOWN
Conditions: Hyperlipidemia, Familial Combined
Interventions: DRUG: Atorvastatin 20mg|DRUG: Omega-3-acids ethylesters 90 4g|OTHER: Placebo(Omega-3-acids ethylesters 90)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of BCD-100 (Anti-PD-1) in Combination With Platinum-Based Chemotherapy With and Without Bevacizumab as First-Line Treatment of Subjects With Advanced Cervical Cancer (FERMATA)
Status: RECRUITING
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: BCD-100|BIOLOGICAL: Bevacizumab|DRUG: Paclitaxel|DRUG: Cisplatin (or Carboplatin)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Multifaceted Intervention to Improve Prescribing in Patients With Chronic Kidney Disease
Status: UNKNOWN
Conditions: Chronic Kidney Disease
Interventions: BEHAVIORAL: computer decision support tool|BEHAVIORAL: audit and feedback|BEHAVIORAL: group learning session
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial
Status: COMPLETED
Conditions: Heart Failure|Anemia|Cardiovascular Disease|Ventricular Dysfunction|Congestive Heart Failure
Interventions: DRUG: Darbepoetin alfa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ORal IrON Supplementation With Ferric Maltol in Patients With Heart Failure Carrying Left Ventricular Assist Devices
Status: TERMINATED
Conditions: Heart Failure, Left Sided|Anemia, Iron Deficiency
Interventions: DRUG: Ferric maltol 30 mg (Feraccru®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Trial of Idiotypic Vaccination for Chronic Lymphocytic Leukemia Using a Genetic Approach
Status: TERMINATED
Conditions: Leukemia, Lymphocytic, Chronic
Interventions: BIOLOGICAL: CLL vaccine using DNA plasmid vector
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Traxi Panniculus Retractor on Surgical Time at Non-emergent Cesarean Delivery in Obese Women
Status: WITHDRAWN
Conditions: Obesity
Interventions: OTHER: Traxi Panniculus Retractor (TPR)|OTHER: Silk Tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NitrX Total Knee Arthroplasty RSA
Status: RECRUITING
Conditions: Total Knee Arthroplasty|Knee Osteoarthritis|Radiostereometric Analysis
Interventions: DEVICE: Total Knee Arthroplasty with Evolution® NitrX™ Knee System|DEVICE: Total Knee Arthroplasty with Evolution Knee System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Controlled Study of Digitalized Cognitive Behavioral Intervention for Antenatal Depression
Status: RECRUITING
Conditions: Depression|Antenatal Depression
Interventions: BEHAVIORAL: Digitalized CBT with phone coaching|OTHER: Psychoeducation about depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Home Visit Supported Nursing Education Program on Some Parameters in Elderly People Living Alone at Home
Status: RECRUITING
Conditions: Old Age; Debility|Loneliness|Healthy Lifestyle
Interventions: BEHAVIORAL: Home Visit Supported Nursing Training Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: AHSCT With Fludarabine and Cyclophosphamide Based Conditioning Regimes in Patients With Multiple Sclerosis
Status: RECRUITING
Conditions: Multiple Sclerosis
Interventions: DRUG: Fludarabine Phosphate for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib in Combination With Osimertinib in EGFR-Mutated Advanced Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: Niraparib|DRUG: Osimertinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peri-implantitis Treatment: Clinical Results of Conventional Treatment vs. the Addition of Biolase
Status: COMPLETED
Conditions: Peri-Implantitis
Interventions: DEVICE: Er,Cr:YSGG laser|PROCEDURE: Scaling|DEVICE: Inactive Er,Cr:YSGG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Respiratory Strength Training in Cardiac Surgical Patients
Status: COMPLETED
Conditions: Cardiovascular Diseases|Thoracic Diseases|Surgery|Surgery--Complications|Dysphagia
Interventions: BEHAVIORAL: Respiratory Strength Training (RST) Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Suprachoroidal Injection of CLS-TA in Patients With Non-infectious Uveitis
Status: COMPLETED
Conditions: Uveitis|Uveitis, Posterior|Uveitis, Anterior|Uveitis, Intermediate|Panuveitis
Interventions: DRUG: 4 mg CLS-TA Suprachoriodal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacokinetics, Activity and Safety of Ruxolitinib in Pediatric Patients With Grade II-IV Acute Graft vs. Host Disease
Status: COMPLETED
Conditions: Acute Graft Versus Host Disease
Interventions: DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peg-Interferon Alpha 2b Combined With Two Intravenous Broadly HIV-1 Neutralizing Antibodies 3BNC117 and 10-1074 (BEAT-2)
Status: UNKNOWN
Conditions: HIV|HIV/AIDS|HIV-1 Infection
Interventions: DRUG: Pegylated Interferon alpha 2b (peg-IFN-α2b)|DRUG: 3BNC117 + 10-1074
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: REVERSE-Long COVID-19 With Baricitinib Study
Status: NOT_YET_RECRUITING
Conditions: Post-Acute COVID-19 Syndrome
Interventions: DRUG: Baricitinib 4 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: US Pivotal Clinical Study of the Adient Absorbable Filter for the Prevention of Pulmonary Embolism
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Embolism
Interventions: DEVICE: Adient absorbable filter + best practice VTE prophylaxis|DEVICE: best practice VTE prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study for Patients With Poor Response to Deferasirox
Status: COMPLETED
Conditions: Transfusion-dependent Hemachromatosis|Thalassemia Major|Sickle Cell Disease
Interventions: DRUG: Deferoxamine|DRUG: Deferasirox|RADIATION: HIDA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere) [SMART] Trial for Non-Small Cell Lung Cancer (NSCLC)
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Docetaxel and cisplatin|RADIATION: Docetaxel and cisplatin Plus Hypofractionated Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Dexmedetomidine on Quality of Recovery in Non-functioning Pituitary Adenoma Patients Undergoing Endoscopic Transsphenoidal Surgery
Status: UNKNOWN
Conditions: Non-functioning Pituitary Adenoma
Interventions: DRUG: Dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Accuracy, Reliability and Safety of GlucoMen®Day, a New Generation Microdialysis Continuous Glucose Monitor
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DEVICE: GlucoMenDay|DEVICE: GlucoMenDay
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: High Dose Gefitinib for the Treatment of Carcinomatous Meningitis in Adult Patients With Non-Small Cell Lung Cancer and Known or Suspected EGFR Mutations
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity & Safety of GSK's Avian Flu Vaccine 1557484A Given to Adults Aged 18-64 Years
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: GSK A/turkey H5N1 Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Boric Acid in Degree 2 Furcation Defect
Status: COMPLETED
Conditions: Chronic Periodontitis With Mandibular Degree 2 Furcation Defects
Interventions: DRUG: 0.75 % Boric Acid|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE)
Status: NOT_YET_RECRUITING
Conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma
Interventions: RADIATION: De-escalation|RADIATION: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Bupivacaine vs. Bupivacaine Hydrochloride and Lidocaine During Suburethral Sling Placement
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Liposomal Bupivacaine|DRUG: Bupivacaine Hydrochloride and Lidocaine|PROCEDURE: Suburethral Sling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Electroacupuncture for Chronic Neck Pain
Status: UNKNOWN
Conditions: Neck Pain
Interventions: DEVICE: electroacupuncture|DEVICE: Sham laser acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks
Status: COMPLETED
Conditions: Hereditary Angioedema
Interventions: BIOLOGICAL: C1 esterase inhibitor [human] (C1INH-nf)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase I Study of Gemcitabine or S-1 Adjuvant Therapy After Hemihepatectomy for Biliary Tract Cancer
Status: COMPLETED
Conditions: Biliary Tract Cancer
Interventions: DRUG: Gemcitabine|DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Health Status and Its Socio-economic Covariates of the Older Population in Poland - the Nationwide PolSenior2 Survey.
Status: UNKNOWN
Conditions: Aging Disorder|Age Problem|Healthy Aging|Immunity Disorders|Frailty Syndrome|Behaviors, Health|Health Care Utilization
Interventions: OTHER: medical history, blood and urine tests
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Influence of a PPMTM on Adherence and Clinical Outcomes Among Preterm Infants With Iron Supplementation
Status: COMPLETED
Conditions: Preterm Infants|Clinical Outcome|Pharmaceutical Care
Interventions: OTHER: pharmacists involved PPMTM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Safety, Efficacy and Thermogenesis-induction of RZL-012 in Overweight and Obese Volunteers
Status: COMPLETED
Conditions: Obesity|Weight Loss|Overweight and Obesity
Interventions: DRUG: RZL-012|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Clonidine to Ropivacaine in Adductor Canal Block
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Clonidine|DRUG: Placebo|DRUG: Ropivacaine|DRUG: Dexamethasone|DRUG: Epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transversus Abdominis Plane Block vs Continuous Infiltration Wound Catheter for Analgesia After Caesarean Section
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: USG-TAP block|DRUG: CIC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: |Primary Purpose: TREATMENT
Clinical trial: Antimicrobial Effect of Different Pastes on Streptococcus Mutans in Children
Status: COMPLETED
Conditions: Mutans Streptococci|Oral Health
Interventions: OTHER: CPP-ACP paste|OTHER: Fluoride toothpaste|OTHER: Both (Fluoride and CPP-ACP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial Imaging of the Novel Radiotracer [^18F] FLuorthanatrace ([^18F] FTT) by PET/CTF
Status: RECRUITING
Conditions: Breast Carcinoma|Fallopian Tube Carcinoma|Ovarian Carcinoma|Primary Peritoneal Carcinoma|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma|Solid Neoplasm
Interventions: PROCEDURE: Computed Tomography|PROCEDURE: Computed Tomography|RADIATION: Fludeoxyglucose F-18|RADIATION: Fluorine F 18 Fluorthanatrace|PROCEDURE: Positron Emission Tomography|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Drug to Drug Interaction Study With Ipragliflozin and Furosemide
Status: COMPLETED
Conditions: Healthy Subjects|Pharmacokinetics of Ipragliflozin
Interventions: DRUG: Ipragliflozin|DRUG: Furosemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis
Status: COMPLETED
Conditions: Sepsis|Septic Shock
Interventions: DRUG: Vitamin C|DRUG: Hydrocortisone|DRUG: Complex B
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy
Status: NOT_YET_RECRUITING
Conditions: Fiberoptic Bronchoscopy
Interventions: DRUG: Ciprofol|DRUG: Remimazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)
Status: RECRUITING
Conditions: Organ Transplant Failure or Rejection|Brain Death|Ischemic Reperfusion Injury
Interventions: DRUG: Tacrolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Body Composition Sub-study of the D2EFT Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV Infections
Interventions: DRUG: Darunavir (DRV) 800 milligram (MG) Oral Tablet|DRUG: Ritonavir 100 MG Oral Tablet|DRUG: N(t)RTIs|DRUG: Dolutegravir 50 MG Oral Tablet|DRUG: TDF 300 MG Oral Tablet|DRUG: 3TC 300 MG Oral Tablet|DRUG: FTC 200 MG Oral Cap
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy
Status: COMPLETED
Conditions: Periodontitis
Interventions: DRUG: Lepidium Sativum|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of Meningococcal ACYW135 Polysaccharide Conjugate Vaccine in Volunteers Aged From 3 to 5 Months
Status: ACTIVE_NOT_RECRUITING
Conditions: Meningitis, Meningococcal
Interventions: BIOLOGICAL: Meningococcal ACYW135 Polysaccharide Conjugate Vaccine|BIOLOGICAL: Meningococcal A and C Polysaccharide Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Real-world Evaluation of Brolucizumab for the Treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD) (IRIS Study)
Status: COMPLETED
Conditions: Age-related Macular Degeneration (AMD)
Interventions: DRUG: Brolucizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention
Status: COMPLETED
Conditions: Human Papilloma Virus|Cervical Cancer|Human Papillomavirus Infection|Oropharyngeal Cancer|Vaginal Cancer|Vulvar Cancer|Anal Cancer|Penile Cancer
Interventions: BEHAVIORAL: WoW and BNI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Neoadjuvant Nivolumab for Oral Cancer Combined With FDG and Anti-PD-L1 PET/CT Imaging for Response Prediction
Status: UNKNOWN
Conditions: Oral Cavity Squamous Cell Carcinoma
Interventions: DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Severe Heart Failure to Function and Molecular Biological Parameters of Catabolism in the Human Diaphragm and Peripheral Skeletal Muscle
Status: COMPLETED
Conditions: Heart Failure|Ischemic Myocardiopathy|Dilatative Myocardiopathy
Interventions: OTHER: Biopsy of the diaphragmatic muscle|OTHER: Skeletal muscle biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
Status: RECRUITING
Conditions: Hemiplegia and/or Hemiparesis Following Stroke|Anterior Circulation Stroke of Uncertain Pathology
Interventions: DEVICE: InTENSity 10 TENS Stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Can Probiotic Vivomixx Eradicate Colonization With ESBL?
Status: COMPLETED
Conditions: Antibiotic Resistant Infection
Interventions: DIETARY_SUPPLEMENT: Vivomixx|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gemcitabine and Cisplatin/Carboplatin Plus Erlotinib in Patients With Nasopharyngeal Cancer
Status: COMPLETED
Conditions: Nasopharyngeal Cancer
Interventions: DRUG: Gemcitabine|DRUG: Carboplatin/Cisplatin|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Preliminary Efficacy of SBRT in Patients With Metastatic RCC Treated With Targeted or IO Therapy
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)
Status: COMPLETED
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer|Advanced Solid Tumor With Evidence of Germline or Somatic BRCA
Interventions: DRUG: Rucaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of a Modified Vaccinia Ankara (MVA)-Based Vaccine Modified to Express Brachyury and T-cell Costimulatory Molecules (MVA-Brachyury-TRICOM)
Status: COMPLETED
Conditions: Lung Cancer|Breast Cancer|Prostate Cancer|Tumors (Others)|Ovarian Cancer
Interventions: BIOLOGICAL: MVA-brachyury- TRICOM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Evaluation of Partial and Complete Pulpotomy in Permanent Molars
Status: UNKNOWN
Conditions: Pulpitis - Irreversible
Interventions: PROCEDURE: Pulpotomy to the level of canal orifices|PROCEDURE: Pulpotomy up to superficial 2-3 mm of pulp chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lumen Apposing Metal Stents vs Lumen Apposing Metal Stent Plus Double Pigtail Stent for Endoscopic Drainage
Status: TERMINATED
Conditions: Pancreatic Pseudocyst
Interventions: DEVICE: Lumen Apposing Metal Stent (LAMS)|DEVICE: LAMS plus double pigtail stent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three Dimensional Versus Standard Miniplate In Fixation Of Mandibular Angle Fracture- A Prospective Randomized Controlled Clinical Trial
Status: COMPLETED
Conditions: Displaced Mandibular Angle Fracture
Interventions: DEVICE: 3D titanium miniplate|DEVICE: Standard titanium miniplate- single non compression miniplate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
Status: UNKNOWN
Conditions: Osteoarthritis of the Knee
Interventions: DRUG: celecoxib|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Optimize RV Follow-up Selective Site Pacing Clinical Trial
Status: COMPLETED
Conditions: Cardiac Pacing|Right Ventricular Pacing|Left Ventricular Ejection Fraction
Interventions: DEVICE: Medtronic or Vitatron Dual-Chamber Pacemaker|DEVICE: Medtronic SelectSecure 3830 Lead
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Overlapping Neural Circuits in Pediatric OCD
Status: COMPLETED
Conditions: Obsessive Compulsive Disorder
Interventions: BEHAVIORAL: CBT treatment for OCD based on Exposure & Response Prevention (EX/RP) and when indicated medication treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Androgen Therapy for Management of Estrogen/Progesterone Receptor Negative ER(-)PR(-) Metastatic Breast Cancer
Status: TERMINATED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Fluoxymesterone 10 mg|DRUG: Anastrozole 1 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extended-Release Tacrolimus Following Liver Transplantation
Status: RECRUITING
Conditions: Liver Transplant; Complications|Renal Insufficiency|Immunosuppressant Adverse Reaction|Metabolic Syndrome|Cardiovascular Diseases
Interventions: DRUG: Envarsus Oral Product|DRUG: Prograf (SOC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Nocebo Effect: a Prospective Study of Informed Consent as a Factor in the Prevalence of SSRI's Side Effects
Status: UNKNOWN
Conditions: Depression
Interventions: BEHAVIORAL: Wording of the explenation on side-effects as part of the informed consent.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Brief Intervention for Sleep Medication Misuse Among Elderly
Status: RECRUITING
Conditions: Harmful Use of Hypnotic
Interventions: BEHAVIORAL: BI (Brief Intervention)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Continous Quadratus Lumborum Block for Hepatic Surgery With Right Subcostal Incision
Status: TERMINATED
Conditions: Hepatectomy|Analgesia|Nerve Block
Interventions: PROCEDURE: Continous QLB (quadratus lumborum block)|DEVICE: Philip CX50 Ultrasound Scanner|DRUG: Ropivacaine|DRUG: Morphine given as IPCA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metabolic Response to Chardonnay Grape Marc Powder
Status: COMPLETED
Conditions: Dyslipidemia|Obesity
Interventions: DIETARY_SUPPLEMENT: Chardonnay grape marc marc high polyphenol dose (120mg)|DIETARY_SUPPLEMENT: Chardonnay grape marc powder low polyphenol dose (75mg)|DIETARY_SUPPLEMENT: Placebo (0mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The International Collaborative Exfoliation Syndrome Treatment Study
Status: UNKNOWN
Conditions: Exfoliation Syndrome|Glaucoma|Ocular Hypertension
Interventions: DRUG: Latanoprost with Pilocarpine vs Timolol or Cosopt
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CADDIE Trial - Computer Aided Diagnosis and Detection for Intelligent Endoscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Polyps|Adenoma Colon|Colorectal Polyp|Colon Polyp
Interventions: DEVICE: CADDIE- Computer Aided (AI) Device used in Endoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p