pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Central Processing of Odour Stimuli in Patients With Functional Somatic Disorder or MCS Compared to Healthy Controls
Status: ENROLLING_BY_INVITATION
Conditions: Functional Disorder|Bodily Distress Syndrome|Multiple Chemical Sensitivity
Interventions: DIAGNOSTIC_TEST: MRI and paraclinical tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability and Efficacy of Indacaterol in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)
Status: COMPLETED
Conditions: COPD
Interventions: DRUG: Indacaterol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Analgesic Effects of Wound Infiltration Using Bupivacaine, Tramadol, and Tramadol Plus Bupivacaine
Status: NOT_YET_RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: bupivacain-tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety of Co-Administered CHI-554 and Alcohol
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: CBD oil|DRUG: CBD oil|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: An Observational Study Called H2H-OSCAR-US to Learn More About How Well Rivaroxaban Works and How Safe it is Compared to Apixaban Under Real World Conditions in People in the US With Cancer Who Have Problems Due to Formation of Blood Clots in the Veins (Venous Thromboembolism)
Status: COMPLETED
Conditions: Treatment of Venous Thromboembolism in Cancer Patients|Venous Thromboembolism|Cancer
Interventions: DRUG: Rivaroxaban (Xarelto, BAY59-7939)|DRUG: Apixaban
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Long-term Antibody Persistence of MenACWY-TT Vaccine (PF-06866681) Versus Meningitec(Registered) or Mencevax(Registered) ACWY in Healthy Adolescents and Adults and a Booster Dose of MenACWY-TT Administered 10 Years Post Primary Vaccination
Status: COMPLETED
Conditions: Infections, Meningococcal
Interventions: BIOLOGICAL: Meningococcal vaccine GSK134612
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Multicenter Pragmatic Implementation Study of ECG-AI-Based Clinical Decision Support Software to Identify Low LVEF
Status: RECRUITING
Conditions: Ventricular Ejection Fraction
Interventions: DEVICE: Anumana Low EF AI-ECG Algorithm|OTHER: Care-as-Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Patients Infected With HIV Since More Than 10 Years With a Plasma Viral RNA <400 Copies / mL in the Absence of Any Treatment: Study Mechanisms Involved in Controlling the Infection
Status: COMPLETED
Conditions: HIV Infection
Interventions: BIOLOGICAL: blood test at day one
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Study of FG-4592 in Subjects With Chronic Kidney Disease in China
Status: COMPLETED
Conditions: Anemia in Chronic Kidney Disease
Interventions: DRUG: FG-4592|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Placebo Controlled Trial on the Efficacy of Sustained Natural Apophyseal Glide (SNAG) in Low Back Pain Patients
Status: COMPLETED
Conditions: Low Back Pain|Manual Therapy|Sustained Natural Apophyseal Glide (SNAG)
Interventions: DEVICE: SNAG|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scarpa´s Fascia in the Formation of Seroma Post Abdominoplasty After Bariatric Surgery
Status: UNKNOWN
Conditions: Seroma
Interventions: PROCEDURE: abdominoplasty with Scarpa's Fascia|PROCEDURE: Abdominoplasty without Scarpa´s Facia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Single Dose, Weight-Based, Dose-Escalation Study With Intravenous ETI-204 in Adult Volunteers
Status: COMPLETED
Conditions: Anthrax
Interventions: DRUG: ETI-204, "Anthim"|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Idalopirdine Tablets 60 mg
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Idalopirdine 60 mg formulation A (test)|DRUG: Idalopirdine 60 mg formulation B (reference)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of PRO 140 by Subcutaneous Administration in Adult Subjects With HIV -1 Infection
Status: COMPLETED
Conditions: HIV -1 Infection|HIV Infections
Interventions: DRUG: PRO 140 (humanized monoclonal antibody to CCR5)|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Laser Therapy in Managing Vaginal Prolapse
Status: UNKNOWN
Conditions: Cystocele|Vaginal Vault Prolapse|Rectocele|Enterocele
Interventions: DEVICE: Erbium Yttrium Aluminum Garnet (Er:YAG) laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on the Efficacy of Androgen Deprivation Therapy Combined With Anti-PD-1 Therapy in Advanced Lung Cancer
Status: RECRUITING
Conditions: NSCLC, Stage III|NSCLC, Stage IV
Interventions: DRUG: Leuprorelin acetate + Sintilimab|DRUG: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vietnam Cryptococcal Retention in Care Study - Version 2.1
Status: UNKNOWN
Conditions: HIV/AIDS|Cryptococcal Meningitis|Opportunistic Infections, HIV Related|Cryptococcosis|Mycosis; Opportunistic|Mycosis Fungoides
Interventions: OTHER: Preemptive high-dose Fluconazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Letrozole and Urinary Purified FSH in Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome.
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: FSH|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Stages IB, IIA, IIB, and IIIA/T3
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Carboplatin and Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabeloop for Highly Unstable Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Brittle|Closed-Loop
Interventions: DEVICE: Low Glucose Predictive Suspend system|DEVICE: DBLHU System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Effect of Acupressure Applied Before Cystectomy on Preoperative Anxiety Level
Status: RECRUITING
Conditions: Anxiety|Hemodynamic Instability
Interventions: OTHER: Acupressure|OTHER: Placebo acupressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Atrial Fibrillation Detected by ELR and Holter Recording, a Comparison in Patients With Ischemic Stroke or TIA
Status: COMPLETED
Conditions: Stroke|Ischaemic Stroke|Atrial Fibrillation|Supra Ventricular Extra Systoles
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
Status: RECRUITING
Conditions: Type 1 Diabetes Mellitus With Hypoglycemia
Interventions: DRUG: Placebo|DRUG: ZT-01, 7 mg|DRUG: ZT-01, 15 mg|DRUG: ZT-01, 22 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Low-Intensity Pulsed Ultrasound on Functional Treatment of Class II Malocclusion
Status: COMPLETED
Conditions: Malocclusion, Angle Class II
Interventions: DEVICE: Twin-block|OTHER: LIPUS (Low-intensity pulsed ultrasound)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A+ Treatment/Feasibility of Adapted ESDM-informed Caregiver Coaching Delivered Remotely for Children With ASD (Autism Spectrum Disorder) and ADHD (Attention Deficit Hyperactivity Disorder)
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Adhd
Interventions: BEHAVIORAL: P-ESDM informed caregiver coaching
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Nephral 400 ST Dialysis Membrane on Coagulation in Hemodialysis
Status: COMPLETED
Conditions: Extracorporeal Clotting During Hemodialysis
Interventions: DEVICE: AN69ST dialysis membrane|DEVICE: Fx8 (Fresenius)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Combined Carfilzomib and Hydroxychloroquine in Patients With Relapsed/Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Hydroxychloroquine|DRUG: Carfilzomib Injection|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intervention Effect of High Definition Transcranial Direct Current Stimulation (HD-tDCS) on Anxiety Disorder
Status: RECRUITING
Conditions: Transcranial Direct Current Stimulation|Anxiety|Magnetic Resonance Imaging
Interventions: DEVICE: High definition transcranial direct current stimulation|DEVICE: sham high definition transcranial direct current stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Digital Wearable Walking Aid for Freezing of Gait in Parkinson´s Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Intelligent cueing|BEHAVIORAL: Feedback about the number of steps
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study to Characterize the Bioavailability and Plasma Profile of Potato Polyphenols in Humans
Status: COMPLETED
Conditions: Premenopausal Women|Overweight and Obese Women
Interventions: DIETARY_SUPPLEMENT: Active Comparator|DIETARY_SUPPLEMENT: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Extended Low-Molecular Weight Heparin VTE Prophylaxis in Thoracic Surgery
Status: COMPLETED
Conditions: Venous Thromboembolism|Lung Neoplasms|Pulmonary Embolism
Interventions: DRUG: LMWH: Dalteparin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study of Oral Venetoclax in Combination With Intravenous Pembrolizumab in Adult Participants With Previously Untreated Non-Small Cell Lung Cancer (NSCLC) With High Programmed Cell Death Ligand-1 (PD-L1) Expression
Status: TERMINATED
Conditions: Non Small Cell Lung Cancer|Cancer
Interventions: DRUG: Venetoclax|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Idarubicin Overcomes MDR1 Induced Chemoresistance With Higher Induction Remission Rate and Quality Than Daunorubicin in Acute Myeloid Leukemia Patients
Status: UNKNOWN
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Idarubicin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: GIP: Glucose-dependent Insulinotropic Peptide
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: GIP|DRUG: Modified GIP|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Pyramax in Mild to Moderate COVID-19 Patients
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Pyronaridine-Artesunate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial Evaluating an Alternating Schedule of Recombinant Human GM-CSF and Azidothymidine in Patients With HIV Infection and Leukopenia
Status: COMPLETED
Conditions: HIV Infections|Cytopenias
Interventions: DRUG: Zidovudine|DRUG: Sargramostim
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bridging the Docosahexaenoic Acid (DHA) Gap: The Effects of Omega-3 Fatty Acid Supplementation in Premature Infants
Status: COMPLETED
Conditions: Prematurity
Interventions: DIETARY_SUPPLEMENT: DHA oil|DIETARY_SUPPLEMENT: (MCT) Control oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Analytical Specificity of Bladder EpiCheck Test in Healthy Population and Urology Patients Without Prior History or Evidence of Bladder Cancer
Status: COMPLETED
Conditions: Non Muscle Invasive Bladder Cancer|Non-Muscle Invasive Bladder Urothelial Carcinoma
Interventions: DIAGNOSTIC_TEST: Bladder EpiCheck
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence Study of UH-AC 62 XX Tablets Compared With the Capsule Formulations in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: UH-AC 62 XX tablet|DRUG: UH-AC 62 XX capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BIOlogics in Severe Nasal POlyposis SurvEy.: a French Registry
Status: NOT_YET_RECRUITING
Conditions: Rhinosinusitis Chronic|Nasal Polyps
Interventions: DRUG: Biologic treatments available in Chronic Rhinosinusitis with Nasal Polyps (dupilumab, mepolizumab and benralizumab according to their marketing approval).
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Presbyopic Correction Lens on Humphrey Visual Field Testing in Patients With Multifocal Intraocular Lens
Status: COMPLETED
Conditions: Glaucoma|Cataract Senile
Interventions: DIAGNOSTIC_TEST: Humphrey visual field testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAP Block Using Liposomal Bupivacaine for Post-cesarean Delivery Analgesia- Walking Towards Recovery
Status: RECRUITING
Conditions: Opioid Use|Pain, Acute
Interventions: DRUG: Liposomal bupivacaine (LB)|DRUG: Dexamethasone and methylprednisolone (CG)|DRUG: Control group (Bupivacaine)- (BPG)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Pilot Study of Percutaneous Correction of Hallux Valgus
Status: RECRUITING
Conditions: Hallux Valgus
Interventions: PROCEDURE: SERI osteotomy|PROCEDURE: percutaneous osteotomy according to Chevron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Clinical Investigation of Adaptative Eyeglasses for the Correction of Presbyopia
Status: COMPLETED
Conditions: Presbyopia
Interventions: DEVICE: Prototype of adaptive eyeglasses|DEVICE: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ultrasound and Photoacoustic Imaging for Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer|Cancer of the Cervix
Interventions: DEVICE: Transvaginal probe using photoacoustic and ultrasound imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Impact of Ultra-long Versus Long Down-regulation Protocol on IVF/ICSI in Adenomyosis
Status: WITHDRAWN
Conditions: Adenomyosis
Interventions: DRUG: 11.25mg GnRH agonist|DRUG: 0.1 mg GnRH agonist|DRUG: 25 µg transdermal oestradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of NSK-SD (Nattokinase) on Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: NSK-SD (nattokinase)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NEOadjuvant Chemotherapy Only Compared With Standard Treatment for Locally Advanced Rectal Cancer
Status: RECRUITING
Conditions: Colorectal Neoplasm|Colorectal Cancer|Rectal Neoplasms|Chemotherapy Effect|Intestinal Disease|Intestinal Neoplasms|Rectal Cancer
Interventions: DRUG: Capecitabine|DRUG: FOLFOX regimen (oxaliplatin/leucovorin/5FU)|DRUG: CAPOX (oxaliplatin/capecitabine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: the Potential Immunomodulatory Effects of Spirulina on Thalassemic Children
Status: COMPLETED
Conditions: Beta Thalassemia Major
Interventions: DIETARY_SUPPLEMENT: Spirulina
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Optimizing Phototesting and Investigating Photobiology of Visible Light
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DEVICE: Light Source B: Visible Light solar simulator (VL + UVA1)|DEVICE: Light Source A: Visible Light solar simulator closer match to sunlight (VL +UVA1)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Relationship of Essential Fatty Acids to Adult ADHD: The OCEAN Study (Oils and Cognitive Effects in Adult ADHD Neurodevelopment)
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DIETARY_SUPPLEMENT: Experimental fatty acid supplementation|DIETARY_SUPPLEMENT: Placebo comparator: MCT oil softgel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of Ansofaxine Hydrochloride Extended-release Tablets in the Treatment of Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)
Interventions: DRUG: LY03005 extended-release tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Based Enoxaparin in Trauma Patients
Status: UNKNOWN
Conditions: Venous Thromboembolism
Interventions: DRUG: Dosing of enoxaparin for VTE prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the Use of a Urin Test Strip to Determine the Spread of Schistosoma Infections in Areas Where Schistosomiasis Infections Are Low in Kenya
Status: COMPLETED
Conditions: Schistosomiasis Mansoni|Circulating Cathodic Antigen Urine Based Dipstick
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM
Status: COMPLETED
Conditions: Disorder of Glucose Regulation
Interventions: DRUG: Sitagliptin-Metformin|DRUG: Metformin|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of CT-996 in Overweight/Obese Participants and Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 2 Diabetes|Overweight or Obesity
Interventions: DRUG: CT-996|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Adding Sodium Bicarbonate 8.4% to Local Anesthesia on Pain During Upper Canine Infiltration
Status: ENROLLING_BY_INVITATION
Conditions: Local Anesthetic Complication
Interventions: PROCEDURE: Buffered Local anaesthesia|PROCEDURE: Unbuffered Local anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Atazanavir /Dolutegravir/Lamivudine Regimen as Maintenance Regimen
Status: TERMINATED
Conditions: HIV-1 Infection
Interventions: DRUG: Atazanavir|DRUG: Dolutegravir|DRUG: Lamivudine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thymus Transplantation in DiGeorge Syndrome #668
Status: COMPLETED
Conditions: DiGeorge Syndrome|Complete Typical DiGeorge Anomaly
Interventions: BIOLOGICAL: Cultured Thymus Tissue for Implantation (CTTI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Scapulathoracic Stabilization Exercises Plus Complex Decongestive Therapy in Women With Lymphedema
Status: UNKNOWN
Conditions: Lymphedema|Exercise
Interventions: OTHER: Scapulatoracic stabilization exercises|OTHER: Complex decongestive therapy (CDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Exercise With and Without HMB on Body Composition and Muscle Strength in Sickle Cell Anaemia
Status: UNKNOWN
Conditions: Sickle Cell Anemia
Interventions: BEHAVIORAL: Resistance exercise|DIETARY_SUPPLEMENT: β-hydroxy-β-methylbutyrate|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of ASTX660 in Patients With Relapsed or Refractory T-cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsed or Refractory Peripheral T-cell Lymphoma(PTCL),Cutaneous T-cell Lymphoma(CTCL),Adult T-cell Leukemia/Lymphoma(ATLL)
Interventions: DRUG: ASTX660|DRUG: ASTX660|DRUG: ASTX660
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-vivo Efficacy Study of Patient Pre-operative Preps
Status: COMPLETED
Conditions: Bacterial Reduction on Skin Flora Post-product Application
Interventions: DRUG: ChloraPrep Hi-Lite Orange|DRUG: Normal saline|DRUG: 3M CHG/IPA Prep Tint 10.5-mL|DRUG: 3M CHG/IPA Prep Tint 26-mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antidepressants, Emotions and Personality
Status: COMPLETED
Conditions: Antidepressive Agents, Second-Generation
Interventions: DRUG: Citalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low Level Laser Therapy Plus Topical Clonazepam Treatment to Burning Mouth Symdrome
Status: UNKNOWN
Conditions: Burning Mouth Syndrome
Interventions: COMBINATION_PRODUCT: low level laser therapy plus topical clonazepam|DRUG: Sham laser plus topical clonazepam|RADIATION: Active laser plus placebo of topical clonazepam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fiducial Localization and Individualized Radiotherapy -Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DEVICE: Transrectal APT Device or Transperineal Device will be used|DEVICE: TRUS probe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Of Durvalumab and Lenalidomide In R/R EBV Associated DLBCL Subtypes, Primary CNS And Testicular DLBCL
Status: WITHDRAWN
Conditions: EBV Related Non-Hodgkin's Lymphoma|Primary CNS Lymphoma|Primary Testicular Lymphoma
Interventions: DRUG: Durvalumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of KUC 7483 Tablets in Healthy Male Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: KUC 7483 CL|DRUG: Placebo|OTHER: High fat meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy and Safety of Atorva® 20mg Versus Lipitor® 20mg
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: generic formulation of atorvastatin (Atorva®)|DRUG: branded formulation of atorvastatin (Lipitor®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study
Status: RECRUITING
Conditions: Aortic Valve Disease|Conduction Disturbances
Interventions: DEVICE: Implantable loop recorders system Reveal ICM LINQ®,
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exenatide for the Treatment of Weight Gain Associated With Olanzapine in Obese Adults
Status: COMPLETED
Conditions: Weight Gain
Interventions: DRUG: Exenatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Participants will be prescribed an approved selective serotonin re-uptake inhibitor (SSRI) antidepressant.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Donidalorsen (IONIS-PKK-LRx) Administered Subcutaneously to Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Placebo|DRUG: Donidalorsen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: 2-day Prophylactic Antibiotic is Effective in Transoral Endoscopic Thyroidectomy
Status: COMPLETED
Conditions: Thyroid Nodule
Interventions: DRUG: Amoxicillin Clavulanate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Intergenerational Community Based Participatory Research (CBPR) Intervention to Reduce Appalachian Health Disparities
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: LHA-delivered energy balance classes/activities
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: SAD Study to Assess the Safety, Tolerability, PK, and In-Vivo Performance of AMT-126 in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: AMT-126|DRUG: Placebo|OTHER: Radioactive Tablet (Part 2 Only)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety, and Tolerability of Oral OPC-34712 and Aripiprazole for Treatment of Acute Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: OPC-34712|DRUG: Placebo|DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effect of Mucinex® 1200 mg on Mucociliary and Cough Clearance From the Human Lung
Status: COMPLETED
Conditions: Mucociliary Clearance
Interventions: DRUG: Mucinex 1200mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prevalence of Extracardiac Coronary Collateral Supply Via the Internal Mammary Arteries
Status: COMPLETED
Conditions: Coronary Artery Disease|Collateral Circulation|Ischemia
Interventions: PROCEDURE: Coronary Angiography with collateral flow measurements|PROCEDURE: Coronary Angiography with collateral flow measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioavailability, Safety and Tolerability of Diazepam Nasal Spray Versus Diazepam Rectal Gel (Diastat®)
Status: TERMINATED
Conditions: Refractory Epilepsy
Interventions: DRUG: diazepam nasal spray|DRUG: diazepam rectal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weekly Versus no Routine Ventilator Circuit Changes in NICU
Status: TERMINATED
Conditions: Pneumonia, Ventilator-Associated
Interventions: DEVICE: Infant Ventilator Circuit Dual Heated with Autofeed Chamber
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of the Effectiveness of Peginterferon Alfa-2a (Pegasys) and Ribavirin Treatment in Slovenian Hepatitis C (HCV) Patients
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peginterferon alfa-2a|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Semaglutide 2.4mg for Low Responders After Bariatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Obesity|Obesity, Morbid|Weight Gain
Interventions: OTHER: Placebo|DRUG: Semaglutide 2.4 MG/0.75 ML Subcutaneous Solution [WEGOVY]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetics of Rezafungin
Status: TERMINATED
Conditions: Fungal Infection
Interventions: OTHER: Placebo|DRUG: Rezafungin|DRUG: Rezafungin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pilot Study of Veliparib (ABT-888) and Lapatinib (Tykerb) in Patients With Metastatic, Triple Negative Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Triple Negative Breast Cancer
Interventions: DRUG: Combination of Veliparib + Lapatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multifunctional Nutrition Tube on Social Condition and Experience in Cerebralvascular Accident
Status: NOT_YET_RECRUITING
Conditions: Stroke
Interventions: BEHAVIORAL: comprehensive rehabilitation therapy|DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
Status: UNKNOWN
Conditions: Periodontitis|Periodontal Diseases|Periodontal Pocket|Intrabony Periodontal Defect
Interventions: COMBINATION_PRODUCT: PPF+NCHA bone graft substitute
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multicenter Study to Evaluate CRx-102 vs. Each of Its Components to Treat Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: CRx-102 (2.7/180)|DRUG: prednisolone|DRUG: dipyridamole|DRUG: placebo|DRUG: CRx-102 (2.7/360)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Brain Metastases
Interventions: DIAGNOSTIC_TEST: Brain Imaging with 18F-FES
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Aliskiren vs Negative Controls on Aortic Stiffness in Patients With MFS
Status: COMPLETED
Conditions: Marfan Syndrome
Interventions: DRUG: Aliskiren|DRUG: Atenolol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Camrelizumab With Dalpiciclib for Resectable Head and Neck Squamous Cell Carcinomas
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Dalpiciclib 100mg|DRUG: Dalpiciclib 150mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Modulation of Gut Microbiota in Overweight/Obese Adolescents and COVID-19 Infection
Status: RECRUITING
Conditions: Health Behavior|Child Development|Adolescent Obesity
Interventions: DIETARY_SUPPLEMENT: Probiotics|BEHAVIORAL: Counselling on healthy eating, physical activity, and psychosocial stimulation|DIETARY_SUPPLEMENT: Placebo probiotics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Adjuvant Melatonin for Prevention of Lung Cancer Recurrence and Mortality
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DIETARY_SUPPLEMENT: melatonin|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Pharmacokinetics, Pharmacodynamics, and Disintegration Time of Vaginal Tablets Containing Tenofovir and/or Emtricitabine
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Tenofovir (TFV) Alone Vaginal Tablet|DRUG: Emtricitabine (FTC) Alone Vaginal Tablet|DRUG: TFV and FTC Combined Vaginal Tablet|DRUG: Placebo Vaginal Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Lower-limb Phantom Pain Syndrome Using Peripheral Nerve and Spinal Cord Stimulation
Status: ENROLLING_BY_INVITATION
Conditions: Phantom Limb Pain|Phantom Pain|Amputation|Lower Limb Amputation
Interventions: PROCEDURE: Implantation of PNS electrodes during surgery, mapping to select sites with the best effect and daily modulation.|PROCEDURE: SCS electrode implantation at surgery, mapping to select sites with the best effect and pain modulation|PROCEDURE: Change according to the scale of the PainDetect questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma
Status: RECRUITING
Conditions: Recurrent World Health Organization (WHO) Grade II Glioma|Recurrent WHO Grade III Glioma|WHO Grade II Glioma|WHO Grade III Glioma
Interventions: DRUG: Hyperpolarized Carbon C 13 Pyruvate|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Magnetic Resonance Spectroscopic Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Imagery Rescripting and Imaginal Exposure for Anxiety Symptoms
Status: RECRUITING
Conditions: Social Anxiety|Generalized Anxiety|Obsessive-Compulsive Symptom|Panic
Interventions: BEHAVIORAL: Imaginal exposure for memories|BEHAVIORAL: Imaginal exposure for future events|BEHAVIORAL: Imagery rescripting for memories|BEHAVIORAL: Imagery rescripting for future events
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: OXD01 in Combination With Sublingual Buprenorphine/Naloxone for Treatment of Opioid Use Disorder
Status: COMPLETED
Conditions: Opioid-use Disorder
Interventions: DEVICE: OXD01 digital therapy|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Study to Assess the Effect of CYP3A4 Induction on the Pharmacokinetics of VELCADE (Bortezomib)
Status: COMPLETED
Conditions: Multiple Myeloma|Non-Hodgkin's Lymphoma
Interventions: DRUG: bortezomib|DRUG: bortezomib, rifampicin|DRUG: bortezomib, dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radial Extracorporeal Shock Wave Therapy for Chronic Non-specific Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain
Interventions: DEVICE: rESWT|DRUG: Celecoxib|DRUG: Eperisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep Quality After Total Joint Arthroplasty ( TJA)
Status: WITHDRAWN
Conditions: Pain After TJA
Interventions: DRUG: Melatonin 5 mg|DRUG: Placebo Oral Tablet|DRUG: Magnesium 500Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of CJ-30001 and CJ-30002 in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: Metformin|DRUG: CJ-30001/CJ-30002
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Treatment in Spinal Surgery
Status: COMPLETED
Conditions: Lumbar; Injury
Interventions: DRUG: Acetaminophen|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: PROCEDURE: local infiltration analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer
Status: TERMINATED
Conditions: CDKN2A-p16 Positive|HPV Positive Oropharyngeal Squamous Cell Carcinoma|Stage I Oropharyngeal Squamous Cell Carcinoma AJCC V7|Stage II Oropharyngeal Squamous Cell Carcinoma AJCC V7|Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7|Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7
Interventions: DRUG: Alpelisib|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacodynamic Study|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Development of The Pediatric Physical Activity Tracking Platform (Pedi@Ctivity) and Smartwatch-based Big Data Analysis
Status: RECRUITING
Conditions: Physical Activity|Adolescent|Childhood Rheumatic Disease
Interventions: OTHER: Pedi@ctivity Analysis and Tracking Mobile Applications and Web Platform
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Status: UNKNOWN
Conditions: Chronic Prostatitis|Chronic Pelvic Pain Syndrome
Interventions: OTHER: Acupuncture|OTHER: Sham acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of End Tidal Carbon Dioxide (EtCO2) Variation After an End- Expiratory Occlusion Test as a Predictive Criteria of Fluid Responsiveness in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Preload Responsiveness|Fluid Responsiveness
Interventions: OTHER: measure of EtCO2 variation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Acupuncture for Chemical Therapy Induced Nausea and Vomiting
Status: COMPLETED
Conditions: Chemotherapy-induced Nausea and Vomiting
Interventions: PROCEDURE: Manual acupuncture implemented by senior acupuncturists|PROCEDURE: Manual acupuncture implemented by junior acupuncturists|PROCEDURE: Manual acupuncture on P6 point
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of TISSEEL Lyo Compared to Manual Compression as an Adjunct to Haemostasis
Status: COMPLETED
Conditions: Adjunct to Hemostasis During Vascular Surgery
Interventions: BIOLOGICAL: TISSEEL Lyo|PROCEDURE: Manual compression with surgical gauze pads
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Thiamine as a Metabolic Resuscitator After Cardiac Arrest
Status: TERMINATED
Conditions: Cardiac Arrest
Interventions: DRUG: Thiamine 500 mg IV|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Educational Interventions for Chronic Obstructive Pulmonary Disease (COPD) Self-management in Ethno-cultural Communities
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: BEHAVIORAL: Group one|BEHAVIORAL: Group two|BEHAVIORAL: Group three|BEHAVIORAL: Group four
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Using Augmentative & Alternative Communication to Promote Language Recovery for People With Post-Stroke Aphasia
Status: UNKNOWN
Conditions: Post-stroke Aphasia|Aphasia
Interventions: BEHAVIORAL: AAC for Language Recovery (AAC-LaRc)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cooling in Mild Encephalopathy
Status: NOT_YET_RECRUITING
Conditions: Neonatal Encephalopathy|Newborn Asphyxia
Interventions: PROCEDURE: Whole body hypothermia|PROCEDURE: Targeted normothermia|OTHER: Supportive neonatal intensive care|DIAGNOSTIC_TEST: Follow up assessment at 2 years of age
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Therapeutic Value and Mechanism of Recombinant Human Interleukin-2 on Children With Rheumatic Diseases
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: DRUG: IL-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study With Ciprofloxacin Dispersion for Inhalation in Non-CF Bronchiectasis (ORBIT-3)
Status: COMPLETED
Conditions: Non Cystic Fibrosis Bronchiectasis
Interventions: DRUG: Ciprofloxacin dispersion for inhalation|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT