pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Couples Therapy to Enhance Intimacy Between Patients With Advanced or Recurrent Prostate Cancer and Their Partners
Status: COMPLETED
Conditions: Prostate Cancer|Psychosocial Effects of Cancer and Its Treatment|Sexual Dysfunction|Sexuality and Reproductive Issues
Interventions: OTHER: counseling intervention|OTHER: questionnaire administration|PROCEDURE: psychosocial assessment and care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Combined Application of Electrical Stimulation and Volitional Contractions for Muscle Strengthening and Knee Pain Inhibition (Seated Study)
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: Hybrid Training using Electrodes and Joint Motion Sensors|DEVICE: Isokinetic Training with Isokinetic Dynamometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Heterotopic Ossification Prophylaxis
Status: ENROLLING_BY_INVITATION
Conditions: Acetabular Fracture|Heterotopic Ossification
Interventions: PROCEDURE: External Beam Radiation (XRT)|PROCEDURE: Debridement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determination of Drug Levels for Pharmacotherapy of Heart Failure
Status: NOT_YET_RECRUITING
Conditions: Cardiovascular Diseases|Heart Failure With Reduced Ejection Fraction
Interventions: DRUG: Nebivolol|DRUG: Valsartan and Sacubitril|DRUG: Carvedilol|DRUG: Bisoprolol|DRUG: Metoprolol|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: Carfilzomib|DRUG: Dexamethasone|DRUG: Telaglenastat Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation
Status: ENROLLING_BY_INVITATION
Conditions: Inflammatory Response|Oxidative Stress|Oxidative Stress Induction
Interventions: OTHER: Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison of Tocilizumab Versus Tocilizumab/Infliximab in Patients With COVID-19-associated Cytokine Storm Syndrome
Status: COMPLETED
Conditions: Covid19|Cytokine Storm|Corona Virus Infection
Interventions: DRUG: Tocilizumab|DRUG: Infliximab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severely Active Psoriatic Arthritis Subjects With Inadequate Response to Disease Modifying Anti-Rheumatic Drug Therapy
Status: COMPLETED
Conditions: Arthritis|Psoriatic
Interventions: DRUG: adalimumab|DRUG: placebo for adalimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Clinical and Radiographical Outcomes of Different Anterior Cruciate Ligament Reconstruction Techniques
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Tear|Osteoarthritis, Knee
Interventions: PROCEDURE: Anatomical single bundle ACL reconstruction with hamstrings|PROCEDURE: Anatomical single bundle ACL reconstruction with patellar tendon|PROCEDURE: ACL reconstruction with over the top plus lateral plasty technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cone-beam CT in the Diagnosis and Surgical Treatment of Otosclerosis.
Status: RECRUITING
Conditions: Otosclerosis|Cone Beam Computed Tomography|Stapes Fixation
Interventions: DIAGNOSTIC_TEST: Pre-operative planning based on CBCT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Interpretation of Health News Items Reporting Results of Pre-clinical Studies With or Without Spin by English-speaking Patients
Status: COMPLETED
Conditions: The Study Focus on no Specific Condition
Interventions: OTHER: News item with spin|OTHER: News item without spin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Renoprotection in Early Diabetic Nephropathy in Pima Indians
Status: COMPLETED
Conditions: Diabetic Nephropathy
Interventions: DRUG: Losartan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial to Evaluate the Short-term Safety & Efficacy of Brexpiprazole Monotherapy in the Treatment of Adolescents With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Brexpiprazole (OPC-34712)|DRUG: Aripiprazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin Reaction
Status: RECRUITING
Conditions: Hand-foot Syndrome|Hand-foot Skin Reaction
Interventions: DEVICE: Photobiomodulation therapy (PBMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Vertical Ridge Augmentation for Posterior Mandible by Computer Guided Onlay vs Free Hand Onlay Graft
Status: UNKNOWN
Conditions: Vertical Deficeny of Posterior Mandible
Interventions: PROCEDURE: bone positioning surgical guide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Daptomycin in Treating Neutropenia and Fever in Patients With Cancer
Status: COMPLETED
Conditions: Fever|Sweating|Hot Flashes|Infection|Neutropenia|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Daptomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial to Evaluate the Safety and Efficacy of Enjuvia 0.3 mg for the Treatment of Vulvovaginal Atrophy
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Synthetic Conjugated estrogens, B|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation Study for the Efficacy and Safety of PinPointe FootLaser in Treatment for Onychomycosis
Status: TERMINATED
Conditions: Onychomycosis of Toenails
Interventions: DEVICE: PinPointe Foot Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Famitinib Plus Camrelizumab & Famitinib Alone & Famitinib Plus Ifosfamide in Advanced Osteosarcoma
Status: WITHDRAWN
Conditions: Effect of Drugs|Progression|Pediatric Cancer
Interventions: DRUG: Famitinib|DRUG: Ifosfamide|DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia.
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: Lapaquistat acetate and simvastatin|DRUG: Lapaquistat acetate and simvastatin|DRUG: Simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Sequential IV/PO Moxifloxacin in Comparison to IV Levofloxacin Plus IV Ceftriaxone Followed by PO Levofloxacin, in the Treatment of Patients With Community-acquired Pneumonia
Status: COMPLETED
Conditions: Pneumonia
Interventions: DRUG: Avelox (Moxifloxacin, BAY12-8039)|DRUG: Levofloxacin + Ceftriaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Pimecrolimus Cream on Cathelicidin Levels in Subjects With Eczema
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Pimecrolimus|OTHER: Vehicle cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of Climb Up Program for Children With Attention Deficit Hyperactivity Disorder (ADHD) and Dyslexia in a School in India
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|Dyslexia
Interventions: BEHAVIORAL: Climb Up ADHD and Dyslexia Program
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Periodontal Status After the Treatment of Palatally Impacted Canines Using Acceleration Procedures
Status: COMPLETED
Conditions: Impacted Canine
Interventions: DEVICE: Fixed appliances|PROCEDURE: Corticotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bio-availability of Rectal Artesunate in Children With Severe Falciparum Malaria
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: Intrarectal artesunate|DRUG: Intravenous artesunate|DRUG: Intravenous quinine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Nerve Block of the Proximal Interphalangeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot Study
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Nerve block|DRUG: Saline injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Use of Certolizumab Pegol for Treatment of Active Crohn's Disease in Children and Adolescents
Status: TERMINATED
Conditions: Crohn's Disease
Interventions: DRUG: Certolizumab Pegol|DRUG: Certolizumab Pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hemodynamic Changes of the Left Ventricle Following the Use of Extracorporeal Circulation
Status: COMPLETED
Conditions: Coronary Surgery
Interventions: DEVICE: Pressure/Volume Combination Catheter|DEVICE: Transthoracic echocardiography|DEVICE: Transesophageal echocardiogram
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pediatric Catheter-related Thrombosis Imaging Study
Status: COMPLETED
Conditions: Thrombosis
Interventions: PROCEDURE: Ultrasound|DRUG: Magnetic Resonance Imaging with Contrast|PROCEDURE: Magnetic Resonance Imaging without Contrast
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Software-Aided Imaging (Morfeus) for Confirming Tumor Coverage With Ablation in Patients With Liver Tumors, the COVER-ALL Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Malignant Liver Neoplasm
Interventions: PROCEDURE: Ablation Therapy|PROCEDURE: Image-Guided Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Asian Study on Cilostazol Effectivity in Neuropathies of Diabetes Mellitus Type 2-A Pilot Study in the Philippines
Status: COMPLETED
Conditions: Polyneuropathy
Interventions: DRUG: Cilostazol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Telehealth: Diaphragmatic vs. Pelvic Exercise in Postpartum Pregnancy-related Pelvic Girdle Pain
Status: RECRUITING
Conditions: Postpartum|Pregnancy Related|Pelvic Girdle Pain
Interventions: OTHER: Diaphragmatic breathing retraining|OTHER: Pelvic stabilization exercise|OTHER: pelvic anatomy education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Multiple Ascending Dose Study With LY03003 in Patients With Early-stage Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: LY03003 ( Rotigotine, extended-release microspheres)|DRUG: Placebo, extended-release microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans
Status: RECRUITING
Conditions: TBI|Suicide Prevention|Veterans|PTSD|Transdiagnostic|Anger
Interventions: BEHAVIORAL: STEP-Home-SP|BEHAVIORAL: Transition Assistance Program|BEHAVIORAL: VA Solid Start
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects of Intermittent Dietary Restriction on Cardiometabolic Risk in School-aged Children
Status: RECRUITING
Conditions: Cardiovascular Syndrome, Metabolic
Interventions: BEHAVIORAL: Intermittent dietary restriction|BEHAVIORAL: General health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Methods
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Control|PROCEDURE: citric acid plus tetracycline|PROCEDURE: antimicrobial photodynamic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Plasma Amino Acid Appearance After Adding Bacillus Coagulans GBI-30, 6086 to Milk Protein Concentrate
Status: COMPLETED
Conditions: Protein Malabsorption
Interventions: DIETARY_SUPPLEMENT: Bacillus Coagulans GBI-30, 6086
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Online Caregiver Psychoeducation and Support for Alzheimer's
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: BEHAVIORAL: caregiver website support|BEHAVIORAL: caregiver brief supportive phone calls
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Test of Interventions to Prevent Skin Cancer Among Danes on Vacation in High UV Index Sunny Destinations
Status: COMPLETED
Conditions: Sunburn|Ultraviolet Radiation Exposure|Skin Cancer|Malignant Melanoma|Non-melanoma Skin Cancer|Keratinocyte Skin Cancer
Interventions: BEHAVIORAL: Other: Control Group - Minimal Intervention|BEHAVIORAL: Experimental: Protection Routine 1|BEHAVIORAL: Experimental: Protection Routine 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Use of Dexmedetomidine in Children Undergoing Oral Maxillofacial Surgery to Decrease Emergence Delirium
Status: WITHDRAWN
Conditions: Delirium
Interventions: DRUG: dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Effect of Electronic Cigarette Liquid Characteristics in Smokers.
Status: COMPLETED
Conditions: Electronic Cigarettes
Interventions: OTHER: Own Brand Cigarette|OTHER: ECIG 15 mg nicotine, sweetened|OTHER: ECIG 15 mg nicotine, unsweet|OTHER: ECIG 0 mg nicotine, sweetened|OTHER: ECIG 0 mg nicotine, unsweet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: 2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Interventions: RADIATION: Total-Body Irradiation|PROCEDURE: Donor Lymphocyte Infusion|DRUG: Cyclophosphamide|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Tacrolimus|DRUG: Mycophenolate Mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III Safety Study of Ferumoxytol Compared to Ferric Carboxymaltose for the Treatment of Iron Deficiency Anemia (IDA)
Status: COMPLETED
Conditions: Iron Deficiency Anemia
Interventions: DRUG: Ferumoxytol|DRUG: FCM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Outcome Following Laparoscopic Supracervical Hysterectomy Performed With and Without Excision of the Endocervix in a Reverse Cone Pattern
Status: UNKNOWN
Conditions: Vaginal Bleeding
Interventions: DEVICE: Lapcone|PROCEDURE: laparoscopic supracervical hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Permissive Weight Bearing in Displaced Intra-articular Calcaneal Fractures
Status: NOT_YET_RECRUITING
Conditions: Calcaneus Fracture|Displaced Intra-Articular Fracture of Calcaneus (Diagnosis)|Trauma Injury
Interventions: PROCEDURE: Permissive Weight Bearing group|PROCEDURE: Restricted Weight Bearing group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Cervical Cancer Stigma Reduction Intervention Program on Cancer Stigma Score and Cervical Cancer Screening Uptake in Nepal
Status: COMPLETED
Conditions: Cervical Cancer|Stigma|Screening
Interventions: BEHAVIORAL: "Cervical Cancer Stigma Reduction Intervention"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Cardiovascular Health Arterial Stiffness Raspberry and Microbiome (CHARM)
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Red Raspberry Ellagitannin Extract|DIETARY_SUPPLEMENT: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Desipramine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Immunotherapy Combinations in Participants With Gastrointestinal Malignancies
Status: COMPLETED
Conditions: GastroEsophageal Cancer|Colorectal Cancer
Interventions: DRUG: etrumadenant|DRUG: mFOLFOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Efficacy and Safety of Laxymig® as Prophylactic Treatment in Patients With Migraine
Status: COMPLETED
Conditions: Migraine With Aura|Migraine Without Aura
Interventions: DRUG: Laxymig ER (drug)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Vancomycin After Catheter Replacement
Status: NOT_YET_RECRUITING
Conditions: Central Line-associated Bloodstream Infection (CLABSI)|Catheter-related Bloodstream Infection
Interventions: DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Molecular Response in Adult Patients on Nilotinib With Philadelphia Chromosome Positive Chronic Myelogenous Leukemia (Ph+ CML) in Chronic Phase and a Suboptimal Molecular Response to Imatinib
Status: TERMINATED
Conditions: Chronic Myelogenous Leukemia - Chronic Phase
Interventions: DRUG: Nilotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Preoperative Music on Sterile Inflammation Induced by Laparoscopic Surgery
Status: COMPLETED
Conditions: Music Therapy|Cholecystitis/Cholelithiasis|Inflammatory Response|Surgical Injury
Interventions: OTHER: Preoperative application of a bluetooth enabled Headphones.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interleukin-2 and Pembrolizumab for Metastatic Kidney Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Kidney Cancer
Interventions: DRUG: Pembrolizumab|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Creatine Supplementation During Resistance Training for People Recovering From Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: DIETARY_SUPPLEMENT: Creatine monohydrate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Hold Relax With Agonist Contraction and Active Release Therapy on Clinical Outcomes in Piriformis Syndrome
Status: COMPLETED
Conditions: Piriformis Syndrome
Interventions: OTHER: Hold Relax with Agonist Contraction|OTHER: Active Release Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of IMGN901 for Patients With Advanced Solid Tumors and Extensive Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: IMGN901|DRUG: Carboplatin and Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Probiotic and HIIT in Obese Women
Status: COMPLETED
Conditions: Cardiorespiratory Fitness|Metabolism|Anthropometry
Interventions: DIETARY_SUPPLEMENT: Probiotics supplementation|BEHAVIORAL: HIIT training|DIETARY_SUPPLEMENT: Placebo supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of Montelukast on Gastrointestinal Tolerability in Patients With Relapsing Forms of Multiple Sclerosis Receiving Tecfidera
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: dimethyl fumarate|DRUG: montelukast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cervical Cancer Screening Uptake: A Randomised Controlled Trial Assessing the Effect of Sending Invitation Letters to Nonadherent Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: OTHER: Invitation letter + GP reminder|OTHER: Invitation letter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Embryo Culture Under Constant 5% vs Gradient 8%, 5%, 2% Oxygen Concentration
Status: COMPLETED
Conditions: Embryonic Development|Embryo Morphokinetics|Embryo Morphometry
Interventions: OTHER: Experimental intervention: 8-5-2% oxygen gradient concentration in the incubator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Laser Interstitial Thermal Therapy and Lomustine in Treating Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
Status: TERMINATED
Conditions: IDH Family Wildtype|Recurrent Anaplastic Astrocytoma|Recurrent Glioblastoma
Interventions: PROCEDURE: Laser Interstitial Thermal Therapy|DRUG: Lomustine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Poly (ADP-Ribose) Polymerase (PARP) Inhibitor E7016 in Combination With Temozolomide in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: E7016 + TMZ
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab (MK-3475) in Combination With Etoposide/Platinum (Cisplatin or Carboplatin) for Participants With Extensive Stage Small Cell Lung Cancer (MK-3475-604/KEYNOTE-604)
Status: COMPLETED
Conditions: Small Cell Lung Cancer (SCLC)
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Normal saline solution|DRUG: Carboplatin|DRUG: Cisplatin|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Topical Sodium Metabisulfite for the Treatment of Calcinosis in Patients With Systemic Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Systemic Sclerosis|Calcinosis
Interventions: DRUG: Topical 25% sodium metabisulfite (SM) in pediatric cold cream|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stress-Busting Program and QoL, Bio-markers of Immunity/Stress and Cellular Aging
Status: COMPLETED
Conditions: Stress, Psychological|Telomere Shortening|Stress, Physiological
Interventions: BEHAVIORAL: SBP English|BEHAVIORAL: SBP SPANISH
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
Status: RECRUITING
Conditions: Neurologic Diseases|Hemiparesis|Quadriplegia|Muscular Dystrophies|Arthrogryposis|Spinal Cord Injuries|Charcot-Marie-Tooth|Stroke|Weakness of Extremities as Sequela of Stroke|Weakness Due to Upper Motor Neuron Dysfunction|Amyotrophic Lateral Sclerosis|Spinal Muscular Atrophy|Arm Paralysis|Cerebral Palsy
Interventions: DEVICE: Neurosleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Participants With Dementia of the Alzheimer's Type
Status: COMPLETED
Conditions: Agitation in Participants With Dementia of the Alzheimer's Type
Interventions: DRUG: AVP-786-18|DRUG: Placebo|DRUG: AVP-786-28|DRUG: AVP-786-42.63
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Natural Killer (NK) Cell Adback After Allogeneic Stem Cell Transplant With Campath-IH Plus Chemorx for Patients With Lymphoid Malignancies
Status: COMPLETED
Conditions: Lymphoma|Leukemia
Interventions: DRUG: ARA-C|DRUG: BCNU|DRUG: Campath-1H|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Rituximab|OTHER: Allogeneic Stem Cell Transplantation|RADIATION: Total body radiation (TBI)|DRUG: Methotrexate|DRUG: Tacrolimus|PROCEDURE: Adback NK or T Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure Lowering Effect of B-vitamins in Adults With a Genetic Pre-disposition to Elevated Blood Pressure.
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DIETARY_SUPPLEMENT: Riboflavin|DIETARY_SUPPLEMENT: Folic acid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Skeletal Muscle Mitochondria in Ageing
Status: RECRUITING
Conditions: Aging
Interventions: OTHER: Maximal exercise test|OTHER: 3D Ultrasound|OTHER: Dynamometry|OTHER: Exercise test and occlusions|OTHER: Exercise test in MRI|PROCEDURE: Muscle biopsy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Observational Study of Moderna COVID-19 Bivalent Vaccines (Original and Omicron BA.4/BA.5) and 2023 Updated mRNA COVID-19 Vaccines (XBB.1.5)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Moderna COVID-19 Vaccine|BIOLOGICAL: Moderna mRNA1273.222 Booster|BIOLOGICAL: Pfizer COVID-19 Vaccine|BIOLOGICAL: Moderna 2023 Updated COVID-19 vaccine (XBB.1.5)|BIOLOGICAL: Pfizer 2023 Updated COVID-19 vaccine (XBB.1.5)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BrEPEM-LH-22017 for Older Patients With Untreated Hodgkin Lymphoma (HL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Hodgkin Lymphoma
Interventions: DRUG: BrentuximabVedotin (BV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combined Incentive Actions, Focusing on Primary Care, to Improve Cervical Cancer Screening in Women Residing in Socio-economically Disadvantaged and Untracked Geographical Areas: a Hybrid Efficacy and Implementation Trial
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: OTHER: cash incentive|OTHER: no intervention|OTHER: return vaginal self-swab kit in person
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia
Status: COMPLETED
Conditions: Functional Aging|Subjective Cognitive Concerns|Compensation Strategies|Brain Health Activities
Interventions: BEHAVIORAL: Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Busonid® (Budesonide 200 mcg and 400 mcg) to Treat Asthma Not Controlled or Partially Controlled
Status: SUSPENDED
Conditions: Asthma
Interventions: DRUG: Busonid (budesonide 200mcg and 400mcg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Assess the Effect of Novel Glycans on Nitrogen Metabolism of the Gut in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: KB195|OTHER: Polydextrose|OTHER: Pullulan|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Crizotinb or Standard Chemotherapy in Met Exon 14 Skipping Advanced NSCLC
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Crizotinib|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Fitness Levels in Children and Adolescents With Chronic Inflammatory Bowel Disease (CIBD): Crohn's Disease, Ulcerative Colitis, Chronic Unclassified Colitis
Status: UNKNOWN
Conditions: Crohn's Enteritis|Crohn Disease|Inflammatory Bowel Diseases|Colitis, Ulcerative|Granulomatous Enteritis|Granulomatous Colitis|Ileocolitis|Proctocolitis
Interventions: DEVICE: GT3X Actigraph accelerometer.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Effects of Silymarin on Cisplatin Induced Nephrotoxicity in Upper Gastrointestinal Adenocarcinoma
Status: COMPLETED
Conditions: Upper GI Cancer|Cisplatin Adverse Reaction
Interventions: DRUG: Silymarin|DRUG: Placebo|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension
Interventions: DRUG: Valsartan|DRUG: LCZ696|DRUG: Bradykinin|DRUG: Substance P|DRUG: BNP|DRUG: Sitagliptin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy
Status: WITHDRAWN
Conditions: Epilepsy
Interventions: DEVICE: Transcranial Direct Current Stimulation|PROCEDURE: Sham Transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing
Status: ACTIVE_NOT_RECRUITING
Conditions: Periodontal Diseases
Interventions: PROCEDURE: BioXclude™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W)
Status: TERMINATED
Conditions: Atrial Fibrillation|Vascular Risk
Interventions: DRUG: clopidogrel (SR25990C)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects
Status: COMPLETED
Conditions: RSV Infection
Interventions: DRUG: EDP-938|DRUG: EDP-938|DRUG: EDP-938|DRUG: Itraconazole|DRUG: Rifampin|DRUG: Quinidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of Guselkumab and Risankizumab in Healthy Participants and Participants With Psoriatic Arthritis
Status: TERMINATED
Conditions: Arthritis, Psoriatic|Healthy
Interventions: DRUG: Guselkumab|DRUG: Risankizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Cognitive Effects of 6- and 12-weeks Administration of a Food Supplement Containing Phosphatidylserine in Healthy Children Aged 8 to 12 Years
Status: COMPLETED
Conditions: Cognitive Change
Interventions: DIETARY_SUPPLEMENT: Phosphatidylserine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Lyophilized Plasma in Patients With Liver Disease
Status: WITHDRAWN
Conditions: Liver Disease
Interventions: BIOLOGICAL: Lyophilized Plasma|BIOLOGICAL: Licensed Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Open-Label Study of QD Oral Administration of Tivozanib (AV-951) in Subjects With Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Tivozanib (AV-951)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of iNCDSS in Type 2 Diabetes Mellitus Patients
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: iNCDSS based insulin regime|DRUG: routine insulin treatment regime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: On the Impact of Therapeutic Tumor Necrosis Factor-alpha Inhibition on Anogenital Human Papillomavirus Infection
Status: COMPLETED
Conditions: Psoriasis|Inflammatory Bowel Diseases
Interventions: DRUG: TNF-alpha inhibitors|DRUG: Alternative/no medication|OTHER: Alternative/no medication|DRUG: Purine/folic acid analogues
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate Physiologic Dentin Regeneration and Safety of KH001 in the Administration of Erupted Wisdom Tooth With Dentin Caries
Status: NOT_YET_RECRUITING
Conditions: Dentin Caries
Interventions: DRUG: KH001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Neuromuscular Training on Handball Players Selected Physical Fitness Components, Functional Movement and Handball Skills
Status: COMPLETED
Conditions: Inactivity, Physical
Interventions: OTHER: Neuromuscular training|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty
Status: UNKNOWN
Conditions: Epiphora
Interventions: PROCEDURE: Placement of three interrupted sutures after Triangular Three-snip Punctoplasty of the lower punctum|PROCEDURE: Conventional Triangular Three-snip Punctoplasty of the lower punctum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib for Premalignant Breast Disease
Status: RECRUITING
Conditions: Ductal Carcinoma In Situ|Atypical Lobular Hyperplasia|Atypical Ductal Hyperplasia|Lobular Carcinoma In Situ
Interventions: DRUG: Ruxolitinib|DRUG: Placebo (for Ruxolitinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Assessment of Two Reusable Silicone Hydrogel Contact Lenses
Status: COMPLETED
Conditions: Refractive Errors
Interventions: DEVICE: Lehfilcon A contact lenses|DEVICE: Senofilcon A contact lenses|DEVICE: CLEAR CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Analgesic Properties of a Sublingual Wafer Formulation of Ketamine Following Third Molar Extraction
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Placebo|DRUG: ketamine 25 mg|DRUG: ketamine 35 mg|DRUG: ketamine 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: GnRH Agonist Pretreatment in Hysteroscopic Myomectomy
Status: COMPLETED
Conditions: Uterine Myoma
Interventions: DRUG: Triptorelin 3.75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Growth Hormone on Bone Mineral Density in Young Adults With Child-hood Onset Growth Hormone Deficiency
Status: COMPLETED
Conditions: Growth Hormone Disorder|Adult Growth Hormone Deficiency
Interventions: DRUG: somatropin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of the Adherus Dural Sealant System When Used as a Dural Sealant in Cranial Procedures
Status: COMPLETED
Conditions: Elective Cranial Procedures With Dural Incision
Interventions: DEVICE: Adherus Dural Sealant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Cigarillo Warnings Image Sorting Study
Status: NOT_YET_RECRUITING
Conditions: Smoking, Cigar
Interventions: OTHER: Package image sorting with pictorial warnings|OTHER: Package image sorting with Surgeon General text-only warnings|OTHER: Package image sorting with FDA text-only warnings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Clinical Activity of Pegaspargase in Women With Relapsed or Refractory Epithelial Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasms|Fallopian Tube Neoplasms|Primary Peritoneal Neoplasms
Interventions: DRUG: Pegylated L-Asparaginase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Periodontal Disease With Two Different Bioactive Gels for Home Oral Care
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: OTHER: Application of Biorepair Gel|OTHER: Irrigation of Chlorhexidine 1.00% gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: BEHAVIORAL: Self-help materials|DRUG: nicotine patch|OTHER: Smartphone-delivered automated treatment|BEHAVIORAL: Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Trial on ACURATE™ Transapical Implantation in Patients With Severe Symptomatic Aortic Stenosis (2009-01)
Status: COMPLETED
Conditions: Aortic Stenosis Symptomatic
Interventions: DEVICE: ACURATE TA™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Autologous CD8+ T-cells Expressing an Anti-BCMA CAR in Patients With Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: BIOLOGICAL: Descartes-08|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Linagliptin on Endothelial Function
Status: COMPLETED
Conditions: Type 2 Diabetes|Coronary Artery Disease
Interventions: DRUG: Linagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Nimotuzumab Combined With IMRT in Elder Patients With Cervical Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Cervical Squamous Cell Carcinoma
Interventions: DRUG: Nimotuzumab|RADIATION: EBRT combined with brachytherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Open-label Safety Extension Study of 15 and 20 mg of Vortioxetine (Lu AA21004) in Long-term Treatment of Major Depressive Disorder in Adults
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Vortioxetine (Lu AA21004)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical and Radiographic Evaluation of Low-Level Diode Laser Full Pulpotomy in Vital Permanent Teeth
Status: COMPLETED
Conditions: Irreversible Pulpitis|Endodontic Inflammation
Interventions: OTHER: traditional pulpotomy|DEVICE: diode laser pulpotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 89Zr-TLX250 PET/CT in Chinese Patients With Indeterminate Renal Masses or Suspected Recurrent Renal Clear Cell Carcinoma
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Suspected Recurrent Renal Clear Cell Carcinoma|Recurrent Renal Cell Cancer
Interventions: DRUG: 89Zr-Girentuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evaluation of Infigratinib in Patients With Locally Advanced or Metastatic Gastric Cancer or GEJ Adenocarcinoma
Status: TERMINATED
Conditions: Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Infigratinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Cerebral Oxygenation Using Jugular Oximetry in Comatose Patients After Cardiac Arrest
Status: COMPLETED
Conditions: Cerebral Hypoxic Injury|Cardiac Arrest
Interventions: OTHER: BIS Monitor-guided sedation|OTHER: Jugular bulb catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: HIV/AIDS Orphaned and Vulnerable Children Public Health Evaluation
Status: COMPLETED
Conditions: Adolescent Behavior|Risk Reduction Behavior|Stress, Psychological
Interventions: BEHAVIORAL: Interpersonal Psychotherapy for Groups (IPTG)|BEHAVIORAL: Vhutshilo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reactogenicity, Safety and Immunogenicity of a TB/FLU-01L Tuberculosis Vaccine
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: TB/FLU-01L|BIOLOGICAL: TB/FLU-01L
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT