pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Immunogenicity and Safety of MenQuadfi® as a Booster Vaccine in Toddlers 12 to 23 Months, Regardless of the Quadrivalent Meningococcal Conjugate Vaccine Used for Priming in Infancy
Status: RECRUITING
Conditions: Meningococcal Immunisation|Healthy Volunteers
Interventions: BIOLOGICAL: MenACYW conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Rhubarb and Angiotensin Converting Enzyme Inhibitor
Status: TERMINATED
Conditions: Diabetic Kidney Disease
Interventions: DIETARY_SUPPLEMENT: rhubarb extract|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Cavernous Sinus Invasion by Pituitary Adenoma Using Deep Learning Based Denoising MR
Status: COMPLETED
Conditions: Cavernous Sinus Invasion by Pituitary Adenoma
Interventions: DIAGNOSTIC_TEST: MRI with deep learning based denoising
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Treating Major Depression With Yoga: A Prospective, Randomized Controlled Pilot Trial
Status: COMPLETED
Conditions: Depression, Unipolar
Interventions: BEHAVIORAL: Hatha Yoga Practice Group|BEHAVIORAL: Attention Control Education Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analyzing the Brain Alterations of Acupuncture on Patients With CP/CPPS Evaluated by fMRI
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Interventions: DEVICE: Acupuncture|DEVICE: Sham acupuncture|OTHER: fMRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Nopan Treatment of Acute Suicidality
Status: UNKNOWN
Conditions: Suicidality
Interventions: DRUG: Nopan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal
Status: COMPLETED
Conditions: Nutrition
Interventions: DRUG: zinc sulphate dietary supplement|DRUG: iron sulphate-folic acid dietary supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Cobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose Cancer Has Worsened During or After Treatment With Previous Immunotherapy and Atezolizumab Monotherapy in Participants With Previously Untreated Advanced Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: BIOLOGICAL: Atezolizumab|DRUG: Cobimetinib|BIOLOGICAL: Atezolizumab|BIOLOGICAL: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prazosin and Cerebrospinal Fluid (CSF) Biomarkers in Mild Traumatic Brain Injury (mTBI)
Status: TERMINATED
Conditions: Dementia
Interventions: DRUG: prazosin hydrochloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Sanctura XR (Trospium Chloride) for Reducing Overactive Bladder Symptoms in Female Subjects Refractory to Detrol LA (Tolterodine Tartrate Extended Release) Daily
Status: COMPLETED
Conditions: Overactive Bladder
Interventions: DRUG: trospium chloride|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomised,Multi-Center Study of Docetaxol Plus Capecitabine or Cisplatin in Anthracycline-Pretreated Patients With Advanced Breast Cancer
Status: UNKNOWN
Conditions: Advanced Breast Cancer
Interventions: DRUG: docetaxol, cisplatin, capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Explore the Safety and Efficacy of Three Different Doses of Pegaptanib Sodium in Patients With Wet Age-Related Macular Degeneration (AMD)
Status: TERMINATED
Conditions: Macular Degeneration
Interventions: DRUG: Pegaptanib sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Study of the Influence of Vaccination in HIV Viral Load and Immunologic Responses Against HIV
Status: COMPLETED
Conditions: HIV
Interventions: BIOLOGICAL: Hepatitis A|BIOLOGICAL: Hepatitis B|BIOLOGICAL: Influenza|BIOLOGICAL: Pneumococcal|BIOLOGICAL: Tetanus-diphteria|BIOLOGICAL: Varicella|BIOLOGICAL: Measles-Mumps-Rubella
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Placebo-controlled,Dose-escalation Study to Evaluate the Safety and Pharmacokinetics of MEDI8852 in Adults
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: MEDI8852|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of TRN501 in Healthy Volunteers
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DRUG: TRN501 - Dose 1|DRUG: TRN501 - Dose 2|DRUG: TRN501 - Dose 3|DRUG: TRN501 - Dose 4|DRUG: TRN501 - Dose 5|DRUG: TRN501 - Dose 6|DRUG: TRN501 - Dose 7|DRUG: TRN501 - Dose 8
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of a Candidate COVID-19 Vaccine (COV003)
Status: UNKNOWN
Conditions: Coronavirus
Interventions: BIOLOGICAL: ChAdOx1 nCoV-19 single dose + paracetamol|BIOLOGICAL: MenACWY single dose + paracetamol|BIOLOGICAL: ChAdOx1 nCoV-19 two dose + paracetamol|BIOLOGICAL: MenACWY prime & saline placebo boost + paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Comparison of FineVision Intraocular Lenses vs Symfony Intraocular Lenses
Status: COMPLETED
Conditions: Cataract|Lens Opacities|Presbyopia
Interventions: DEVICE: IOL implantation experimental|DEVICE: IOL implantation active comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maraviroc as GVHD Prophylaxis in Transplant Recipients
Status: TERMINATED
Conditions: Diagnoses That Require Stem Cell Transplant|Graft Versus Host Disease (GVHD)
Interventions: DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Autofluorescence-guided Hemithyroidectomy in a Low-volume, Non-parathyroid Insitution: A Randomized Clinical Trial
Status: COMPLETED
Conditions: Autofluorescence|Thyroidectomy|Autotransplantation
Interventions: DEVICE: Fluobeam LX|OTHER: Conventional surgery without NIRAF assistance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness Study of Nivolumab Compared to Placebo in Prevention of Recurrent Melanoma After Complete Resection of Stage IIB/C Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: BIOLOGICAL: Nivolumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Efficacy of Ertapenem Sodium in the Treatment of Complicated Urinary Tract Infections (0826-048)
Status: COMPLETED
Conditions: Urinary Tract Infection
Interventions: DRUG: ertapenem sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Hepatitis C With Pegylated Interferon and Ribavirin in Participants With/Without Substitution Therapy (P05255)
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: BIOLOGICAL: Pegylated interferon alfa-2b (PegIFN-2b)|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ROTEM and Dietary Supplements
Status: WITHDRAWN
Conditions: Dietary Supplements|Bleeding Tendency; Due to Coagulation Defect
Interventions: DIETARY_SUPPLEMENT: Ginger|DIETARY_SUPPLEMENT: Garlic|DIETARY_SUPPLEMENT: Ginkgo Biloba|DIETARY_SUPPLEMENT: Ginseng|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Creatine and Motor Skill Acquisition
Status: UNKNOWN
Conditions: Young Healthy Adults (no Medical Condition/Disease)
Interventions: DIETARY_SUPPLEMENT: Creatine Monohydrate|DIETARY_SUPPLEMENT: Maltodextrin Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi Syndrome
Status: TERMINATED
Conditions: Prader-Willi Syndrome|Obesity
Interventions: DRUG: ZGN-440 for Injectable Suspension|DRUG: ZGN-440 Placebo for Injectable Suspension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cold Acclimation as a Modulator of Brown Adipose Tissue Function in Adults With Obesity
Status: RECRUITING
Conditions: Obesity
Interventions: OTHER: Cold acclimation|OTHER: Intervention Control group - volunteers with obesity|OTHER: Acute cold exposure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of High Intensity Interval Exercise Training in Patients With Allergic Rhinitis
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: OTHER: High-intensity interval training group (HIIT)|OTHER: Moderate continuous training group (MCT)|OTHER: Sedentary control group (CON)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumor|Breast Cancer
Interventions: DRUG: DS-1103a|DRUG: T-DXd
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radioligand fOr locAl raDiorecurrent proStaTe cancER
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: 177Lu-PNT2002|RADIATION: High Dose Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries
Status: COMPLETED
Conditions: General Surgery
Interventions: DRUG: Nicardipine|DRUG: Urapidil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Unimalleolar Versus Bimalleolar Fixation in Bi- or Trimalleolar Ankle Fracture
Status: SUSPENDED
Conditions: Trauma
Interventions: PROCEDURE: Unimalleolar fixation|PROCEDURE: Bimalleolar fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RIPC and Platelet Activation on Platelet Activation During Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Platelet Dysfunction
Interventions: DEVICE: Remote ischemic preconditioning|DEVICE: Sham control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tislelizumab Plus Cetuximab and Irinotecan vs Third-line Standard-of-care in Refractory mCRC
Status: RECRUITING
Conditions: Colorectal Neoplasms Malignant
Interventions: DRUG: Tislelizumab Combined With Cetuximab and Irinotecan|DRUG: Third-line regimens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clarithromycin,Lenalidomide and Dexamethasone for Relapsed/Refractory Myeloma
Status: WITHDRAWN
Conditions: Relapse/Refractory Multiple Myeloma
Interventions: DRUG: clarithromycin|DRUG: Lenalidomide|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Study Called STAR-T to Learn More About the Sequential Treatment With Regorafenib and TAS-102 in Adults With Metastatic Colorectal Cancer Under Real World Conditions
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Colorectal Cancer (mCRC)
Interventions: DRUG: Regorafenib (BAY73-4506, Stivarga®)|DRUG: TAS-102 (trifluridine and tipiracil, Lonsurf®)|DRUG: Bevacizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Translation of COPE for Publicly-Funded Home Care Clients and Their Families
Status: COMPLETED
Conditions: Dementia|Alzheimer's Disease
Interventions: BEHAVIORAL: Care of Persons with Dementia in their Environments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias
Status: COMPLETED
Conditions: Anxiety Disorders|Specific Phobia
Interventions: BEHAVIORAL: One-session exposure treatment|BEHAVIORAL: Augmented one-session exposure treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Carbamazepine for the Treatment of Chronic Post-Traumatic Brain Injury Irritability and Aggression
Status: COMPLETED
Conditions: Traumatic Brain Injury
Interventions: DRUG: Carbamazepine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: VIC Regimen Versus Bevacizumab Plus Chemotherapy as First-Line Treatment for BRAF V600E-Mutated Advanced Colorectal Cancer
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: VIC|DRUG: Bevacizumab Plus Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Linking Microcredit, Technology, and Promotion of IYCF Breastfeeding Guidelines in Bauchi State, Nigeria
Status: COMPLETED
Conditions: Breast Feeding Exclusive|Initiation of Breastfeeding
Interventions: BEHAVIORAL: Breastfeeding promotion intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: TaxoteRe Plus Cisplatin Versus AlImta Plus Cisplatin in 1st Line Non-squamous Cell Type Lung Cancer
Status: TERMINATED
Conditions: Carcinoma, Non Small Cell Lung
Interventions: DRUG: Taxotere|DRUG: Pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Whole Body Vibration Exercises for Patients wıth Chronic Nonspeific Low Back Pain
Status: COMPLETED
Conditions: Pain|Labor Pain|Quality of Life|Disability Physical
Interventions: OTHER: classic lumbar home exercise|DEVICE: Whole body vibration|OTHER: Whole body vibration exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Feasibility of Pulmonary Surgery Marker System in the Intraoperative Localization of Small Pulmonary Nodules
Status: COMPLETED
Conditions: Lung Neoplasms
Interventions: DEVICE: LungBrella marker implantation and VATS partial lobe resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: S-NOR (s-amlodipine) 2,5 mg & 5 mg tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mediterranean Diet and the Microbiota Gut Brain Axis in Major Depression
Status: NOT_YET_RECRUITING
Conditions: Depression
Interventions: OTHER: Mediterranean Diet|OTHER: Normal hospital diet|OTHER: dietary coaching|OTHER: Psychoeducation on depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Maternal Xylitol Consumption on Mutans Sterptococci
Status: COMPLETED
Conditions: Dental Caries and Streptococcus Mutans Count
Interventions: DRUG: xylitol|DRUG: fluoride varnish application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Audio Based Nutrition Education on Dietary Intake Practice, and Egg-based Diet Intervention on Nutrient Adequacy, and Gestational Weight Gain Among Pregnant Women and Newborn's Birth Weights in the North Sidama Zone, Ethiopia.
Status: ENROLLING_BY_INVITATION
Conditions: Nutritional Deficiency
Interventions: DIETARY_SUPPLEMENT: egg based diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: EUS-Endodrill vs. EUS-FNA for Diagnosis of Submucosal Tumors in the Upper GI Tract
Status: TERMINATED
Conditions: Gastrointestinal Neoplasms
Interventions: DEVICE: EUS-FNA|DEVICE: EUS-Endodrill biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: CO07204-Phase I/II of Oxaliplatin, Capecitabine & Sorafenib for Advanced Pancreatic & Biliary Carcinoma
Status: COMPLETED
Conditions: Pancreatic Neoplasms|Bile Duct Neoplasms
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or Refractory Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Recurrent Myeloproliferative Neoplasm|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: Cytarabine|BIOLOGICAL: Filgrastim|DRUG: Fludarabine|DRUG: Fludarabine Phosphate|DRUG: Ivosidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Nebulized Morphine and Intravenous Morphine in Post Traumatic Pain
Status: COMPLETED
Conditions: Post Traumatic Pain
Interventions: DRUG: nebulized morphine|DRUG: Intravenous morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the KLOX BioPhotonic WoundGel System in the Treatment of Surgical Wounds
Status: COMPLETED
Conditions: Surgical Wounds
Interventions: DEVICE: KLOX BioPhotonic WoundGel System|DEVICE: Silicone sheets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ramucirumab (LY3009806) in Combination With Paclitaxel in Participants With Gastric Cancer
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Ramucirumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS
Status: COMPLETED
Conditions: Smoking|Tobacco Smoking|Tobacco Use
Interventions: OTHER: THS Blade device|OTHER: THS Induction Mono device|OTHER: THS Induction Mid device|OTHER: CIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluation of Investigational Daily Disposable Multifocal Contact Lenses Produced With Different Manufacturing Processes
Status: COMPLETED
Conditions: Visual Acuity
Interventions: DEVICE: JJVC Investigational Multifocal Contact Lens|DEVICE: Dailies Total 1® Multifocal Contact Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Post-Intubation Tracheal Stenosis and Covid-19
Status: COMPLETED
Conditions: Tracheal Stenosis|COVID-19|Post-Intubation Subglottic Stenosis|Intensive Care Unit
Interventions: PROCEDURE: tracheal stenosis follow-up file
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: 68Ga-PSMA-11 PET/MRI in Finding Tumors in Patients With Intermediate or High-Risk Prostate Cancer Undergoing Surgery
Status: COMPLETED
Conditions: Stage II Prostate Adenocarcinoma|Stage III Prostate Adenocarcinoma
Interventions: DRUG: 68Ga-PSMA-11|PROCEDURE: Magnetic resonance imaging (MRI)|PROCEDURE: Positron Emission Tomography (PET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Intraoperative Sedatives and Postoperative Deilirium
Status: COMPLETED
Conditions: Lower Extremity Problem|Delirium|Propofol|Dexmedetomidine
Interventions: DRUG: Propofol|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Randomized Study Comparing the Adenoma Detection Yield of SC, AI and Combined AI and G-EYE®
Status: UNKNOWN
Conditions: Colorectal (Colon or Rectal) Cancer|Adenoma
Interventions: DEVICE: Standard Colonoscopy|DEVICE: Artificial Intelligence Aided Colonoscopy (GI Genius™)|DEVICE: Combined Artificial Intelligence Aided Colonoscopy (GI Genius™) and G-EYE® Balloon Aided Colonoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
Status: RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: Saruparib (AZD5305)|DRUG: Camizestrant|DRUG: Abemaciclib|DRUG: Ribociclib|DRUG: Palbociclib|DRUG: Fulvestrant|DRUG: Letrozole|DRUG: Anastrozole|DRUG: Exemestane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dentofacial Effects Of Two Non-Compliance Appliances In The Treatment Of Growing Skeletal Class III Patients
Status: COMPLETED
Conditions: Malocclusion, Angle Class III
Interventions: OTHER: CS 2000
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Lysine Chloride|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Diode Laser Pulpotomy of Mature Permanent Molars With Irreversible Pulpitis
Status: UNKNOWN
Conditions: Irreversible Pulpitis
Interventions: PROCEDURE: pulpotomy|DEVICE: Diode laser - fonalaser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low and High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Resistant Auditory Hallucination in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: PROCEDURE: high frequency (20Hz)|PROCEDURE: low frequency (1Hz)|PROCEDURE: Sham Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression and/or Generalized Anxiety Disorder
Status: COMPLETED
Conditions: Depression, Anxiety
Interventions: BIOLOGICAL: MET-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel/Pazopanib for Platinum Resistant/Refractory Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Pazopanib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glycemic and Insulinemic Response to Oats Soaked Overnight in Milk Compared to Cream of Rice in Healthy Subjects
Status: COMPLETED
Conditions: Glycemic, Insulinemic, Subjective Appetite Responses
Interventions: OTHER: Cereal - oats|OTHER: Cereal - cream of rice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Autoimmune Basis for Postural Tachycardia Syndrome
Status: RECRUITING
Conditions: Postural Tachycardia Syndrome
Interventions: DEVICE: Vagal stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Exploring the Effect of Fespixon Cream for the Treatment of Diabetic Foot Ulcers (TEXAS 3A, 3B)
Status: TERMINATED
Conditions: Diabetic Foot Ulcer (DFU)
Interventions: DRUG: Fespixon Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery
Status: TERMINATED
Conditions: Pain
Interventions: DRUG: Bupivacaine|DRUG: Hydromorphone|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Belatacept to Prevent Organ Rejection in Kidney Transplant Patients
Status: TERMINATED
Conditions: Renal Transplant
Interventions: DRUG: Belatacept|DRUG: Sirolimus|DRUG: Anti-thymocyte globulin|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Investigate the Effects of Orteronel on the QT/QTc Interval in Patients With Metastatic Castration-Resistant Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Orteronel+Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NB-UVB Phototherapy With and Without Topical LCD Treatment: a Bilateral Pilot Study
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: OTHER: LCD Solution with NB-UVB Phototherapy|DEVICE: NB-UVB Light Device (311-315 nm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: DACC in the REduction of Surgical Site INfection
Status: RECRUITING
Conditions: Infection, Bacterial|Wound Infection|Wound Infection, Surgical|Surgical Incision|Surgical Wound
Interventions: DEVICE: DACC-Coated Post Operative Dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Aerobic Exercise in the Treatment of Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: DRUG: Methylphenidate compounds and /or Amphetamine compounds and/or Strattera or Guanfacine|BEHAVIORAL: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Enfortumab Vedotin in Previously Treated Locally Advanced or Metastatic Pancreatic Cancer (EPIC)
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Pancreas Adenocarcinoma|Pancreas Cancer
Interventions: DRUG: Enfortumab vedotin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: EFV/FTC/TDF|DRUG: Calcium Carbonate|DRUG: Vitamin D3|DRUG: Placebo for calcium carbonate|DRUG: Placebo for vitamin D3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combining Risk Factors and Faecal Immunochemical Testing in Colorectal Cancer Screening: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Colorectal Cancer|Colorectal Carcinoma|Colorectal Neoplasms|Colorectal Adenoma|Colorectal Adenoma and Carcinoma
Interventions: DIAGNOSTIC_TEST: Risk-based logistic regression model|DIAGNOSTIC_TEST: FIT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study to Compare Two Partial Nephrectomy Techniques for Renal Tumors: Robot-assisted vs Videolaparoscopic
Status: NOT_YET_RECRUITING
Conditions: Renal Cancer
Interventions: PROCEDURE: Videolaparoscopic Partial Nephrectomy|PROCEDURE: Robot-assisted Partial Nephrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ABT-652 in Subjects With Excessive Daytime Sleepiness
Status: COMPLETED
Conditions: Sleep Disorder
Interventions: DRUG: ABT-652|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PHASE 1, OPEN-LABEL SAFETY STUDY OF UMBILICAL CORD LINING MESENCHYMAL STEM CELLS (CORLICYTE®) TO HEAL CHRONIC DIABETIC FOOT ULCERS
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: Corlicyte
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Natural History Study for Charcot Marie Tooth Disease
Status: RECRUITING
Conditions: Charcot-Marie-Tooth Disease|Charcot-Marie-Tooth|Charcot-Marie-Tooth Disease, Type IA|Charcot-Marie-Tooth Disease Type 2A|Charcot-Marie-Tooth Disease Type 2|Charcot-Marie-Tooth Disease, Type 2C|Charcot-Marie-Tooth Disease Type 2A2B|Charcot-Marie-Tooth Disease Type 2B2|Charcot-Marie-Tooth Disease Type 2A1|Charcot-Marie-Tooth Disease Type 4B1|Charcot-Marie-Tooth Disease, Type IB|Charcot-Marie-Tooth Disease Type 2B1|Charcot-Marie-Tooth Disease Type 2U (Diagnosis)|Charcot-Marie-Tooth Disease Type 4A|Charcot-Marie-Tooth Disease, Type 4A, Axonal Form|Charcot-Marie-Tooth Disease Type 2A2A|Charcot-Marie-Tooth Disease Type 2S (Disorder)|Charcot-Marie-Tooth Disease and Deafness|Charcot-Marie-Tooth Disease Type 4B2|Charcot-Marie-Tooth Disease Type 4H|Charcot-Marie-Tooth Disease Type 1F|Charcot-Marie-Tooth Disease Type 4C|Charcot-Marie-Tooth Disease Type 4E|Charcot-Marie-Tooth Disease Type 1D|Charcot-Marie-Tooth Disease Type 2Q (Diagnosis)|Charcot-Marie-Tooth Disease Type 2A2|Charcot-Marie-Tooth Disease Type 2N (Diagnosis)|Charcot-Marie-Tooth Disease Type 2B5|Charcot-Marie-Tooth Disease Type 2D|Charcot-Marie-Tooth Disease Type 4D|Charcot-Marie-Tooth Disease Type 2K|Charcot-Marie-Tooth Disease Type 2L (Diagnosis)|Charcot-Marie-Tooth Disease Type 2T|Charcot-Marie-Tooth Disease Type 2I|Charcot-Marie-Tooth Disease Type 2J|Charcot-Marie-Tooth Disease Type 2E|Charcot-Marie-Tooth Disease Type 2G|Charcot-Marie-Tooth Disease Type 1C|Charcot-Marie-Tooth Disease Type 2R|Charcot-Marie-Tooth Disease Type 2O (Diagnosis)|Charcot-Marie-Tooth Disease Type 2M|Charcot-Marie-Tooth Disease Type 2P|Charcot-Marie-Tooth Disease Type 2Y|Charcot-Marie-Tooth Disease Type 4F (Diagnosis)|Charcot-Marie-Tooth Disease Type 4B3|Charcot-Marie-Tooth Disease Type 2H|HNPP|X-Linked Charcot-Marie-Tooth Disease
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Renal Denervation on NO-mediated Sodium Excretion and Plasma Levels of Vasoactive Hormones
Status: UNKNOWN
Conditions: Essential Hypertension
Interventions: DRUG: NG-monomethyl-L-arginine (L-NMMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of K-757 and K-833 in Overweight/Obese Patients With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity|Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: K-757 and K-833 QD|DRUG: K-757 and K-833 BID|DRUG: Matching placebo to K-757 and K-833 QD|DRUG: Matching placebo to K-757 and K-833 BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Phase III Hallmark QUAD: ASV+DCV+Peg+Rib (Nulls/Partials)
Status: COMPLETED
Conditions: Hepatitis C Virus
Interventions: DRUG: Asunaprevir|DRUG: Daclatasvir|DRUG: Peg-interferon Alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of COcoa Supplement in OBese Adolescent Subjects
Status: UNKNOWN
Conditions: Childhood Obesity|Adolescent Obesity
Interventions: DIETARY_SUPPLEMENT: Cocoa Flavonols Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Low Molecular Weight Heparin in Recurrent Implantation Failure
Status: COMPLETED
Conditions: Infertility|Fertilization in Vitro|Recurrent Implantation Failure
Interventions: DRUG: low molecular weight heparin (enoxaparine sodium)|DRUG: crinone 8% gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extending Acute Stroke Trials to the Aerial Inter-hospital Transfer Setting
Status: COMPLETED
Conditions: Stroke
Interventions: DRUG: Ranitidine|DRUG: Placebo|OTHER: Advanced notification|OTHER: No advanced notification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Efficacy and Safety of Continuous Subcutaneous Insulin Infusion of Faster-acting Insulin Aspart Compared to NovoRapid® in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: Faster-acting insulin aspart|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Physiological Effects of Nutritional Support in Patients With Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Idiopathic Parkinson Disease
Interventions: DIETARY_SUPPLEMENT: Intravenous and Oral n-acetyl cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Vitamin D in Postmenopausal Women at High Risk for Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Cholecalciferol|DRUG: Placebo capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Potential Vertebroplasty Use in the Treatment of Vertebral Metastasis From Breast and Prostate Cancer
Status: UNKNOWN
Conditions: Breast Cancer|Prostate Cancer|Vertebral Metastasis|Pain
Interventions: PROCEDURE: Vertebroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: The Use of Kineret (Anakinra) in the Treatment of Familial Cold Urticaria
Status: COMPLETED
Conditions: Familial Cold Urticaria
Interventions: DRUG: Kineret (anakinra)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of PI-88 With Docetaxel in Advanced Non-Small-Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: docetaxel|DRUG: PI-88
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities. CHROmosome MAPping and Sequencing (CHROMAPS)
Status: UNKNOWN
Conditions: Infertility|Intellectual Disability|Malformation
Interventions: GENETIC: Optical Genome Mapping (Bionano®)|GENETIC: Longread sequencing (Nanopore®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Supporting Parents Program: Intervention for Families in CPS
Status: COMPLETED
Conditions: Child Abuse|Child Neglect
Interventions: BEHAVIORAL: Promoting First Relationships (PFR)|BEHAVIORAL: Resource and Referral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phamacokinetics and Safety Profiles of DA-1229_01 2.5/500mg in Healthy Subjects at Fasting State
Status: NOT_YET_RECRUITING
Conditions: Healthy
Interventions: DRUG: DA-1229_01 2.5/500mg (Before)|DRUG: DA-1229_01 2.5/500mg (After)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Manual Therapy Versus TENS in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: OTHER: Manual Therapy|OTHER: TENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo
Status: COMPLETED
Conditions: Vertigo|Dizziness|Benign Paroxysmal Positional Vertigo|Labyrinthitis
Interventions: OTHER: Osteopathic Manipulative Treatment (OMT)|OTHER: Vestibular Rehabilitation Therapy (VRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Improving Sleep and Daytime Functioning Among Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: BEHAVIORAL: Sleep Intervention|DRUG: Melatonin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Treatment of Elderly Patients With Older and Newer Antiepileptic Drugs
Status: COMPLETED
Conditions: Focal Epilepsy
Interventions: DRUG: Levetiracetam|DRUG: Carbamazepine|DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Falls Prevention Evaluation and Development for Older Adults in the Community
Status: COMPLETED
Conditions: Physical Performance|Fear of Falling
Interventions: OTHER: Exercise-based fall prevention intervention (Modified Otago Exercise Programme and Modified Stepping On Programme)|OTHER: Wait-list control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study of the Safety and Effectiveness of GSK6097608 in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Neoplasms
Interventions: DRUG: GSK6097608|DRUG: Dostarlimab|DRUG: Cobolimab|DRUG: Belrestotug
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Povidone-iodine Versus Normal Saline Solution in Vaginal Cleansing in Laparoscopy
Status: COMPLETED
Conditions: Postoperative Infection
Interventions: DRUG: Povidone-iodine solution|DRUG: Normal saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study of LBH589 & Erlotinib for Advanced Aerodigestive Tract Cancers
Status: COMPLETED
Conditions: Lung Cancer|Head and Neck Cancer
Interventions: DRUG: Panobinostat (LBH589)|DRUG: erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scaling up Maternal Health Equity Best Practices
Status: NOT_YET_RECRUITING
Conditions: Maternal Mortality Disparities|Maternal Morbidity Disparities
Interventions: OTHER: Services as usual|OTHER: Scale-up implementation approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: 4 Year Extension Study of Efficacy and Safety of Secukinumab in Patients With Moderate to Severe Chronic Plaque-type Psoriasis
Status: COMPLETED
Conditions: Moderate to Severe Chronic Plaque-Type Psoriasis
Interventions: DRUG: AIN457 150 mg|DRUG: AIN457 300 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: LowCostomy: Dedicated Toward Creating a High-quality, Low-cost Colostomy Appliance for Those in Sub-Saharan Africa
Status: COMPLETED
Conditions: Abdominal Site|Colostomy Site
Interventions: DEVICE: Tanzanian beeswax-pine resin|DEVICE: Domestic beeswax-pine resin|DEVICE: Hollister's AdaptTM Barrier Rings
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Acute Exposure of Simulated Hypoxia on ECG and Non-invasive Blood Pressure
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DEVICE: Simulated Altitude: (FiO2: 15.1)|DEVICE: Shamed Hypoxia (FiO2: 20.9)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Continuous Transversus Abdominis Plane Nerve Block for Postoperative Analgesia
Status: TERMINATED
Conditions: Incisional Pain
Interventions: PROCEDURE: TAP Catheter and Infusion of Study Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Cardiovascular Disease Risk in Perimenopausal Latinas
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Health Behavior|Physical Activity|Self Efficacy|Vascular Stiffness
Interventions: BEHAVIORAL: Education, Physical Activity, and Stress Management Program|OTHER: Wait-list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Refractory Chronic Cough Improvement Via NAL ER (RIVER)
Status: RECRUITING
Conditions: Refractory Chronic Cough
Interventions: DRUG: Nalbuphine ER|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of IBsolvMIR in Islet Transplantation
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: IBsolvMIR|DRUG: Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiosurgery of Ganglion StELlatum In Patients With REFractory Angina Pectoris
Status: RECRUITING
Conditions: Coronary Artery Disease|Angina Pectoris|Myocardial Ischemia
Interventions: PROCEDURE: Radiosurgery of ganglion stellatum
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT