pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Methodology for Developing an Occlusal Appliance With CBD Active Carrier
Status: UNKNOWN
Conditions: Temporomandibular Disorder|Myofascial Pain|Cannabis|Electromyography|Occlusal Appliance|CBD
Interventions: DRUG: CBD occlusal appliance|DEVICE: Acrylic resin occlusal appliance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: MCLA-117 in Acute Myelogenous Leukemia
Status: UNKNOWN
Conditions: Acute Myelogenous Leukemia|Acute Myeloid Leukemia
Interventions: DRUG: MCLA-117 bispecific antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imipenem Versus Cefepime in Spontaneous Bacterial Peritonitis and to Evaluate the Risk Factors for Treatment Failure
Status: COMPLETED
Conditions: Spontaneous Bacterial Peritonitis
Interventions: DRUG: cefepime + Albumin|DRUG: Imipenem + Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Subjects With Liver Function Injury and Subjects With Normal Liver Function
Status: COMPLETED
Conditions: Subjects With Liver Function Injury|Normal Liver Function Subject
Interventions: DRUG: Deuremidevir Hydrobromide Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Dose Escalation and PK Study of M2ES in Subjects With Advanced Solid Tumors
Status: UNKNOWN
Conditions: Advanced Solid Tumors
Interventions: DRUG: M2ES 7.5mg|DRUG: M2ES 15mg|DRUG: M2ES 30mg|DRUG: M2ES 60mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maxillary Sinus Floor Augmentation in Diabetic Patients
Status: NOT_YET_RECRUITING
Conditions: Jaw, Edentulous, Partially|Diabetes
Interventions: PROCEDURE: Sinus floor augmentation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploration of Circulating VE-cadherin in Metastatic Colorectal Adenocarcinoma Patients Treated With Bevacizumab
Status: COMPLETED
Conditions: Colorectal Cancer|Metastasis
Interventions: BIOLOGICAL: Bevacizumab + blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Study Evaluating Safety and Tolerability of YM150 Compared to Warfarin in Subjects With Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: YM150|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT
Status: COMPLETED
Conditions: Leber Congenital Amaurosis (LCA)|Retinitis Pigmentosa (RP)
Interventions: OTHER: No treatment: retrospective chart review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Dose-escalation Study of Ombrabulin in Combination With Paclitaxel and Carboplatin in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: Ombrabulin (AVE8062)|DRUG: Paclitaxel|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Assess the Pharmacokinetics, Safety, and Tolerability of Centanafadine Capsules in Pediatric Subjects With Attention-deficit Hyperactivity Disorder
Status: COMPLETED
Conditions: Attention-deficit Hyperactivity Disorder
Interventions: DRUG: Centanafadine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Bioactive Liquid Efficiency in Improving Dental Implant Osteointegration Oral Soft Tissue Hellingand Oral Surgery
Status: COMPLETED
Conditions: Wound Healing Disorder|Wounds and Injuries|Wound Surgical
Interventions: DEVICE: Dental Implant insertion and tooth extraction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Polyherbal Formulation in Chronic Inactive Carriers of Hepatitis B Virus
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Polyherbal|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The French E3N Prospective Cohort Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|Colo-rectal Cancer|Parkinson Disease|Asthma|Diabetes|Inflammatory Bowel Diseases|Melanoma|Endometriosis|Thyroid Cancer|Hypertension|Endometrial Cancer|Crohn Disease|Depression|Cardiovascular Diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Kaposi Sarcoma
Interventions: DRUG: liposomal doxorubicin|DRUG: pomalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pembrolizumab on the Tumoral Immunoprofile of Gynecologic Cancers
Status: COMPLETED
Conditions: Gynecologic Neoplasms|Epithelial Ovarian Cancer|Uterine Endometrial Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Breastfeeding Success With the Use of the WHO Syringe Technique for Management of Inverted Nipples in Lactating Women
Status: COMPLETED
Conditions: Breastfeeding|Inverted Nipple
Interventions: OTHER: Inverted syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjustment of Chemotherapy Duration in Follicular Lymphoma According to Minimal Residual Disease Status
Status: RECRUITING
Conditions: Follicular Lymphoma
Interventions: DRUG: Bendamustin|DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Light Therapy for Managing Sleep Disturbances in Patients With Advanced Cancer
Status: TERMINATED
Conditions: Advanced Cancers
Interventions: OTHER: Bright Light Therapy|OTHER: Dim Red Light Therapy|BEHAVIORAL: Questionnaires|BEHAVIORAL: Study Diaries|DEVICE: Red Light Litebook|DEVICE: Bright Light Litebook
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Magnesium Administration in Subjects With Family History of Diabetes or Metabolic Syndrome
Status: COMPLETED
Conditions: Family History of Metabolic Syndrome|Family History of Diabetes
Interventions: DRUG: magnesium pidolate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Balance Training on Neuromuscular Control in Subjects With CAI
Status: COMPLETED
Conditions: Ankle Inversion Sprain|Instability, Joint|Treatment|Neuromuscular Control|Reaction Time
Interventions: OTHER: Balance training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Different Protocols in Ovarian Stimulation in Intracytoplasmic Sperm Injection Cycles
Status: WITHDRAWN
Conditions: ART
Interventions: DRUG: Letrozole|DRUG: Menotropins|DRUG: recombinant Follicular stimulating hormone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sustaining Remission From PTSD Using Tuned Vibroacoustic Stimulation (TVS) Following MDMA-Assisted Psychotherapy
Status: RECRUITING
Conditions: Stress Disorders, Post-Traumatic
Interventions: DEVICE: Apollo Wearable
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Study for Combination of Camrelizumab and Apatinib in the Second-line Treatment of Recurrent or Metastatic Adrenocortical Carcinoma
Status: RECRUITING
Conditions: Adrenocortical Carcinoma
Interventions: DRUG: Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors
Status: RECRUITING
Conditions: Cervical Cancer|Prostate Cancer Metastatic|Breast Cancer|Colon Cancer|NSCLC|Cutaneous Melanoma
Interventions: DRUG: ²¹²Pb-DOTAM-GRPR1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Application of Tracheal Intubation in Lateral Position in Thoracic Surgery
Status: UNKNOWN
Conditions: Anesthesia|Tracheal Intubation|Thoracic Surgery
Interventions: OTHER: Changes in intubation position
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Medical Treatment of "High-Risk" Neurofibromas
Status: COMPLETED
Conditions: Neurofibromatosis 1
Interventions: DRUG: Peg-Interferon alpha-2b|DRUG: Celecoxib (Celebrex)|DRUG: Temozolomide (temodar)|DRUG: Vincristine Sulfate (Oncovin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia
Status: COMPLETED
Conditions: Depression|Delirium|Seizures|Cognitive Disorders
Interventions: DRUG: Ketamine|PROCEDURE: Electroconvulsive Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immersive Virtual Reality Environment for Complex Cognitive Skills Curricular Training in Liver Surgery
Status: COMPLETED
Conditions: Hepatobiliary Neoplasm
Interventions: BEHAVIORAL: Clinical decision making based on visualizing liver 3D models in Virtual Reality (VR) environment or via a Desktop Interface (DI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Multicentre, Randomised, Single-blind, Controlled Protocol to Evaluate the Efficacy of Early Administration of Botulinum Toxin for Primary Midline Closure in Patients With Open Abdomen.
Status: NOT_YET_RECRUITING
Conditions: Botulinum Toxin Type A|Open Abdomen|Abdominal Wall|Clinical Trial
Interventions: DRUG: Botulinum Toxin A|OTHER: CONTROL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: BIO-K+ CL1285 for Prevention of Recurrent Clostridium Difficile Infection
Status: SUSPENDED
Conditions: Recurrent Clostridium Difficile Infection
Interventions: DIETARY_SUPPLEMENT: Lactobacillus acidophilus CL1285® and Lactobacillus casei|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Catheter Based Renal Denervation Therapy in Hypertension
Status: UNKNOWN
Conditions: Resistant Hypertension|Renal Denervation|Ambulatory Blood Pressure|Renal Function
Interventions: PROCEDURE: Renal angiography followed by renal sympathetic denervation|PROCEDURE: Renal angiography alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Identify Biomarkers of Clinical Response to Aflibercept in Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: aflibercept + FOLFIRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic and Static Splinting as a Treatment for Plantar Faciiopathy
Status: TERMINATED
Conditions: Plantar Fasciitis|Plantar Fasciopathy
Interventions: DEVICE: Ankle Dorsiflexion Dynasplint|PROCEDURE: Commercially Available Static Night splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Scapular Training in Stroke Individuals
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Neurodevelopmental Treatment (Bobath) + Scapular Training|OTHER: Neurodevelopmental Treatment (Bobath)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: L9LS MAb in Malian Adults
Status: COMPLETED
Conditions: Plasmodium Falciparum Infection|Malaria
Interventions: BIOLOGICAL: L9LS (VRC-MALMAB0114-00-AB)|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Norepinephrine vs Phenylephrine During General Anesthesia
Status: COMPLETED
Conditions: Anesthesia|Surgery|Hypotension
Interventions: DRUG: Norepinephrine|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Pilot Evaluation of a New Galyfilcon A Contact Lens Compared to a Marketed Galyfilcon A Contact Lens
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: galyfilcon A prototype lens|DEVICE: marketed galyfilcon A lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of DCVAC/PCa After Primary Radiotherapy for Patients With High Risk Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Dendritic Cells DCVAC/PCa|RADIATION: Standard radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Input of a Multidisciplinary Device to Accompany the Announce of Diagnosis for Young Children With Serious Constitutional Hemorrhagic Disease and Their Families
Status: COMPLETED
Conditions: Severe Forms of Hemophilia|Other Constitutional Bleeding Disorders
Interventions: BEHAVIORAL: Evaluation of psychological and psychopathological
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ACTIV-6: COVID-19 Study of Repurposed Medications
Status: ACTIVE_NOT_RECRUITING
Conditions: Covid19
Interventions: DRUG: Ivermectin|DRUG: Fluvoxamine|DRUG: Fluticasone|OTHER: Placebo|DRUG: Montelukast|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Liraglutide in Patients With Prediabetes and Kidney Failure
Status: WITHDRAWN
Conditions: Kidney Failure, Chronic|Prediabetic State
Interventions: DRUG: Liraglutide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Identification of In-hospital Patients in Need of Palliative Care Using a New Simplified Screening Tool
Status: COMPLETED
Conditions: Locally Advanced Cancer|Metastatic Cancer|Chronic Respiratory Failure|Chronic Heart Failure|Chronic Liver Failure|Chronic Renal Failure
Interventions: OTHER: Screening for PC by means of two different screening tools
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lifestyle Medicine Strategies for Combating Sleepiness and Fatigue in Professional Drivers
Status: WITHDRAWN
Conditions: Sleepiness, Daytime|Fatigue|Sleep Disorders, Circadian Rhythm
Interventions: BEHAVIORAL: Lifestyle Medicine Strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EDN and Eosinophilic Esophagitis
Status: NOT_YET_RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: BIOLOGICAL: Blood sampling|BIOLOGICAL: Esophageal biopsies|BIOLOGICAL: Unstimulated saliva sampling|BIOLOGICAL: Urine sampling|BIOLOGICAL: Stool sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Multimodal Circuit Exercises for Chronic Musculoskeletal Pain in Older Adults
Status: COMPLETED
Conditions: Musculoskeletal Pain|Chronic Pain
Interventions: OTHER: Multimodal circuit exercise|OTHER: Multidisciplinary lectures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stretching and Strength Training for Improved Gait Function in Children With Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy, Spastic, Diplegic
Interventions: OTHER: Stretching and progressive strength training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PET and EBV DNA-directed Therapy for Localized Nasal Extranodal NK/T Cell Lymphoma
Status: RECRUITING
Conditions: NK-T-Cell Lymphoma, Extranodal
Interventions: DRUG: 4 cycles of ESA regimen with sandwiched radiotherapy|DRUG: 2 cycles of ESA regimen sequential radiotherapy and 2 cycles of PD-1 monoclonal antibody combined with pegaspargase|DRUG: 2 cycles of ESA regimen, 2 cycles of PD-1 monoclonal antibody and concurrent radiotherapy, 2 cycles of PD-1 monoclonal antibody combined with pegaspargase
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Infliximab Efficacy, TDM and Serum TNFα Levels in Pediatric HSCT Recipients With aGVHD: Prospective Observational Study
Status: RECRUITING
Conditions: Graft Versus Host Disease, Acute|Hematopoietic Stem Cell Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Antioxidant Bioavailability
Status: UNKNOWN
Conditions: Pharmacokinetics
Interventions: DIETARY_SUPPLEMENT: Liposomal vitamin C, 1 gram|DIETARY_SUPPLEMENT: Liposomal vitamin C, 2 grams|DIETARY_SUPPLEMENT: Liposomal vitamin C, 5 grams|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Optimization of IV Ketamine for Treatment Resistant Depression
Status: COMPLETED
Conditions: Major Depressive Disorder (MDD)|Treatment Resistant Depression (TRD)
Interventions: DRUG: Ketamine|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Bioavailability Study of Human Chorionic Gonadotropin (hCG)-IBSA Versus a Marketed hCG Formulation
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Human hCG 10'000 IU|DRUG: Recombinant hCG 6'500 IU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Mobility and Cognition in Older Adults Using Non-Invasive Brain Stimulation
Status: TERMINATED
Conditions: Executive Dysfunction|Gait Performance|Repetitive Transcranial Magnetic Stimulation
Interventions: DEVICE: Magstim® Rapid 2 machine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Safety and Efficacy of NK Cells in Subjects With Myelodysplastic Syndromes
Status: NOT_YET_RECRUITING
Conditions: Relapsed / Refractory Myelodysplastic Syndromes
Interventions: DRUG: NCR300
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Adaptive Feeding Plan for Newborns
Status: COMPLETED
Conditions: Infant Nutrition
Interventions: OTHER: BSF|OTHER: BSF + Lactoferrin + Probiotics|OTHER: BSF + Lactoferrin + Probiotics + OS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Tipranavir Dose-response Study Using a Prototype Self-emulsifying Drug Delivery System (SEDDS) Formulation in Treatment-naive HIV-1 Infected Patients Report on the Post-study Option, a Treatment of Triple Therapy With Delavirdine, ZDV and 3TC Without Tipranavir
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Tipranavir (TPV)|DRUG: Ritonavir (RTV)|DRUG: Delavirdine (DLV)|DRUG: Zidovudine (ZDV)|DRUG: Lamivudine (3TC)|DRUG: Stavudine (d4T)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Exploratory Research of Medial Prefrontal Cortex Combined With Dorsolateral Prefrontal Cortex Electrical Stimulation in the Treatment of Alzheimer's Disease
Status: RECRUITING
Conditions: Alzheimer Disease|Electric Stimulation Therapy
Interventions: DEVICE: Cortical brain stimulation of mPFC and dlPFC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Flu2Text: Text Message Reminders for 2nd Dose of Influenza Vaccine
Status: COMPLETED
Conditions: Influenza|Vaccination
Interventions: BEHAVIORAL: Text message influenza vaccine reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Safety and Tolerability of Vildagliptin Versus Placebo in Patients With Type 2 Diabetes and Moderate or Severe Renal Insufficiency (28 Week Extension)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Renal Insufficiency
Interventions: DRUG: vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Acupuncture in Treating Glaucoma
Status: COMPLETED
Conditions: Glaucoma|Acupuncture
Interventions: DEVICE: wang-bu-liu-xing|DEVICE: acupuncture|DEVICE: Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Piloting a Novel, Mobile Cognitive Tracking and Training Tool for Patients With Parkinson's Disease (PD)
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: OTHER: Computerized Plasticity-based Adaptive Cognitive Training|OTHER: Commercially available computerized training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimising 3D pH-Weighted CEST MRI in Acute Ischaemic Stroke (CEST in Stroke)
Status: UNKNOWN
Conditions: Stroke, Acute
Interventions: DIAGNOSTIC_TEST: 3D CEST imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Vildagliptin 50mg Bid as an add-on Therapy to Insulin With or Without Metformin, in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Vildagliptin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Fecal Microbiota Transplantation in the Treatment of Digestive Diseases and Non-digestive System Diseases Associated With Gastrointestinal Symptoms in the Gastrointestinal Tract.
Status: RECRUITING
Conditions: Fecal Microbiota Transplantation
Interventions: PROCEDURE: Fecal microbiota transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EFFICACY: Hopewell Hospitalist: A Video Game Intervention to Increase Advance Care Planning by Hospitalists
Status: COMPLETED
Conditions: Advance Care Planning
Interventions: BEHAVIORAL: Hopewell Hospitalist Video Game
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Post-Approval Clinical Trial of the PCM® Cervical Disc
Status: COMPLETED
Conditions: Radiculopathy|Myelopathy
Interventions: DEVICE: PCM Cervical Disc|DEVICE: Anterior Cervical Discectomy and Fusion (ACDF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV)
Status: COMPLETED
Conditions: Pemphigus Vulgaris (PV)
Interventions: DRUG: Mycophenolate Mofetil 2 g/Day|DRUG: Mycophenolate Mofetil (MMF) 3 g/Day|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Berberine on Hormonal and Metabolic Features in Obese Women With Polycystic Ovary Syndrome (PCOS)
Status: UNKNOWN
Conditions: Polycystic Ovary Syndrome|Obesity
Interventions: DRUG: Berberine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Paraclinical Characteristics of Severe Bronchiolitis in Children From 2 Months to 12 Months at the Children's Hospital 1 in Ho Chi Minh City - Vietnam
Status: UNKNOWN
Conditions: Epidemiological, Clinical, Paraclinical Characterictics of Severe Bronchiolitis
Interventions: BIOLOGICAL: severe bronchiolitis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ex-vivo Sentinel Lymph Node in Stage I-II Colon Cancer: Kappa Analysis With Immunochemistry and Molecular Biology
Status: UNKNOWN
Conditions: Colon Cancer|Lymph Node|Sentinel Node
Interventions: PROCEDURE: Immunochemistry and molecular biology on sentinel lymph node specimen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Electrical Muscle Stimulation (EMS), a Preventive and Therapeutic Tool for Critical Illness Polyneuromyopathy (CIPNM)
Status: UNKNOWN
Conditions: Critical Illness Polyneuromyopathy (CIPNM)|ICU Acquired Weakness (ICUAW)
Interventions: PROCEDURE: EMS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Carbetocin at Elective Cesarean Delivery Part 3
Status: COMPLETED
Conditions: Postpartum Hemorrhage
Interventions: DRUG: Carbetocin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of AOC 1044 in Healthy Adult Volunteers and Participants With Duchenne Muscular Dystrophy (DMD) Mutations Amenable to Exon 44 Skipping
Status: RECRUITING
Conditions: Duchenne Muscular Dystrophy|Exon 44
Interventions: DRUG: AOC 1044|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Application of Radiostereometric Analysis (RSA) to Triathlon Knee Components Inserted Using the OtisMed Custom-fit Total Knee Replacement System
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: PROCEDURE: OtisMed|PROCEDURE: Computer Assisted Surgery (CAS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Efficacy and Safety of Minocycline Hydrochloride Foam in the Treatment of Moderate-to-severe Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: FMX101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Conversation Map on the Health Behaviors of Diabetes Patients
Status: COMPLETED
Conditions: Diabetes Mellitus|Health Knowledge, Attitudes, Practice|Health Behavior|Glycated Hemoglobin (HbA1c)
Interventions: BEHAVIORAL: Map group|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction
Status: COMPLETED
Conditions: Sick Sinus Syndrome|Heart Failure, Congestive|Atrial Fibrillation|Bradycardia|Ventricular Dysfunction
Interventions: DEVICE: Implantable Pulse Generators
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Ultrasound Axillary Vein Access: Evaluation of Learning Curve for an Alternative Approach to Cardiac Device Implantation
Status: COMPLETED
Conditions: Ultrasound Therapy; Complications|Cardiac Device Implant|Venous Access
Interventions: PROCEDURE: Ultrasound guided venous access|PROCEDURE: Conventional technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination
Status: ENROLLING_BY_INVITATION
Conditions: Healthy|Cytotoxicity|Yellow Fever Vaccination Reaction
Interventions: DRUG: Yellow Fever Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Blueberry-polyphenols on Endothelial Function, Absorption and Metabolism
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Blueberry Group|DIETARY_SUPPLEMENT: Placebo Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Impact of Low Fat Dairy and High Fat Dairy Consumption on Daytime Ambulatory Blood Pressure
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: Control diet|OTHER: Milk diet|OTHER: GABA-rich cheese diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Pediatric Patients
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Tetracaine HCl 3% and Oxymetazoline HCl 0.05%|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome
Status: WITHDRAWN
Conditions: Weight Loss|Obesity|Pre-Diabetes|Metabolic Syndrome
Interventions: DEVICE: VA MOVE! Coach app|BEHAVIORAL: Telephone Coaching|BEHAVIORAL: Standard of Care for weight loss.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Transverse Abdominus Plane Catheter Blocks to Patient-controlled Analgesia in Laparoscopic Colon Resections
Status: WITHDRAWN
Conditions: Colorectal Disorders|Observation of Neuromuscular Block
Interventions: DRUG: 0.2% ropivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability and Immunogenicity of Two Vaccinations of Ad26.RSV.preF One Year Apart in Adults Aged 60 Years and Older in Stable Health
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Ad26.RSV.preF 5*10^10 vp|BIOLOGICAL: Ad26.RSV.preF 1*10^11 vp|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Impact of Atorvastatin on Prostate Cancer Progression During ADT
Status: RECRUITING
Conditions: Metastatic Prostate Cancer|Recurrent Prostate Cancer
Interventions: DRUG: Atorvastatin 80mg|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
Status: COMPLETED
Conditions: Dexmedetomidine|General Anesthesia|Cardiac Electrophysiology|Cardiac Function
Interventions: DRUG: Dexmedetomidine|DRUG: Dexmedetomidine|DRUG: Dexmedetomidine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Single and Multiple Ascending Doses of KBL697 in Healthy Subjects
Status: COMPLETED
Conditions: Atopic Dermatitis (AD)
Interventions: DRUG: KBL697|DRUG: KBL697|DRUG: KBL697|DRUG: KBL697
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Olympus EZ Shot 3Plus 19G and EZ Shot 2 19G in EUS-guided FNB of Solid Pancreatic Masses
Status: COMPLETED
Conditions: Pancreatic Neoplasms
Interventions: DEVICE: EUS-FNB with EZ Shot 3Plus first|DEVICE: EUS-FNB with EZ Shot 2 19G first
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The COMPASSION Study
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Metastatic Breast Cancer|Advanced Breast Cancer|Unresectable Breast Carcinoma
Interventions: OTHER: Telehealth Hospice Visits
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Peri-operative Monitoring of Cerebral Oxygenation and the Onset of Delirium in Patients Undergoing Cardiac Surgery
Status: COMPLETED
Conditions: Delirium
Interventions: DEVICE: Near-Infrared Spectroscopy (NIRS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Impact of Exercise on "Invisible" Symptoms and Quality of Life in Multiple Sclerosis Individuals
Status: COMPLETED
Conditions: Multiple Sclerosis|Quality of Life|Motivation|Pain|Headache|Migraine|Anxiety Disorders|Depressive Disorder|Sleep Disorder|Insomnia|Physical Disability|Fatigue
Interventions: BEHAVIORAL: Exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
Status: RECRUITING
Conditions: Acute Kidney Injury KDIGO 3|Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency|Myocardial Stunning
Interventions: PROCEDURE: Continuous renal replacement therapy|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Lactation Study in Women Receiving Treatment With Ozanimod
Status: NOT_YET_RECRUITING
Conditions: Lactating Women|Breastfed Infants
Interventions: DIAGNOSTIC_TEST: Breast milk, plasma, and blood samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension of a Clinical Trial of Intravitreal Triamcinolone for Diabetic Macular Oedema-TDMX Study
Status: COMPLETED
Conditions: Diabetic Macular Oedema
Interventions: DRUG: Triamcinolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Exercises of Different Intensity Applied After Total Knee Arthroplasty on Exercise-Induced Hypoalgesia
Status: COMPLETED
Conditions: Knee Osteoarthritis|Pain, Acute
Interventions: BEHAVIORAL: High Intensity Exercises Program|BEHAVIORAL: Low Intensity Exercises Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Injection of Autologous Adipose Tissue for Treatment of Osteoarthritis in the Knee
Status: COMPLETED
Conditions: Osteo Arthritis Knee
Interventions: OTHER: Injection of Autologous Adipose Tissue|OTHER: Injection of lactated ringers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Hypoglossal Nerve Stimulation in Humans With Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea|Sleep Apnea, Obstructive|Sleep Apnea Syndromes|Sleep Disorder
Interventions: DEVICE: Hypoglossal nerve stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Lixiana Acute Stroke Evaluation Registry
Status: COMPLETED
Conditions: Ischemic Stroke|Atrial Fibrillation|Hemorrhagic Transformation Stroke
Interventions: DRUG: Edoxaban 60 MG|DRUG: Edoxaban 30 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial
Status: COMPLETED
Conditions: Heart Failure|Heart Failure With Reduced Ejection Fraction|Thiamine Deficiency|Congestive Heart Failure
Interventions: DIETARY_SUPPLEMENT: Thiamine|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Open Label Extension Study to Evaluate the Long-term Safety of Zorblisa (SD-101-6.0) in Patients With Epidermolysis Bullosa
Status: TERMINATED
Conditions: Epidermolysis Bullosa
Interventions: DRUG: SD-101-6.0 cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Neu2000KWL for Acute Ischemic Stroke Patients Within 6 Hours of Onset
Status: COMPLETED
Conditions: Stroke|Cerebral Infarction
Interventions: DRUG: Neu2000KWL|DRUG: Neu2000KWL|DRUG: Neu2000KWL|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West Papua
Status: COMPLETED
Conditions: Malaria,Falciparum|Malaria, Vivax|Malaria|Infections|Uncomplicated Malaria|Uncomplicated Plasmodium Falciparum
Interventions: DRUG: Dihydroartemisinin|DRUG: Piperaquine|DRUG: Primaquine|OTHER: Momordica Charantia Extract
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of a Spasticity Management Program for People With Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: BEHAVIORAL: Spasticity Take Control|BEHAVIORAL: Stretching for People with MS: An Illustrated Manual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: PCORI Integrated Care (IC) Models for Patient-Centered Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes|Arthritis|Asthma|Chronic Obstructive Pulmonary Disease|Hypertension|Anxiety|Atrial Fibrillation|Congestive Heart Failure|Depression|Bipolar Disorder|Schizophrenia
Interventions: BEHAVIORAL: High-Touch|BEHAVIORAL: High-Tech|BEHAVIORAL: Usual Care/Optimal Discharge Planning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Tremelimumab With or Without Cryoablation in Treating Patients With Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Metastatic Renal Cell Cancer|Stage IV Renal Cell Cancer AJCC v7
Interventions: PROCEDURE: Cryosurgery|OTHER: Laboratory Biomarker Analysis|PROCEDURE: Therapeutic Conventional Surgery|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Assessing Tolerability and Safety and Exploring the Immunogenicity and Therapeutic Activity of AFFITOPE® PD01A in PD-GBA Patients
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: BIOLOGICAL: AFFITOPE® PD01A + Adjuvant|BIOLOGICAL: Adjuvant without active component
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Prevention and Treatment of Nausea Associated With Motion Sickness in Senior Subjects
Status: COMPLETED
Conditions: Motion Sickness
Interventions: DRUG: Scopolamine|OTHER: Placebo Nasal Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing Radiation Exposure to Operators During Invasive Cardiac Procedures
Status: COMPLETED
Conditions: Patients Undergoing Invasive Cardiac Procedures|Radiation Exposure
Interventions: DEVICE: Novel Lead Based Armboard|DEVICE: Standard Armboard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Upper GI Handling of Branded vs. Generic Alendronate
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: MK0217, alendronate sodium / Duration of Treatment: 1 Month|DRUG: Comparator: Alendronate-Teva / Duration of Treatment: 1 Month
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: A Care Model for Hip-fractured Elderly Persons With Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus|Hip Fracture
Interventions: OTHER: Diabetes interdisciplinary program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2 Study of Gemzar, Taxol & Avastin Combination as 1st Line Treatment for Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Gemcitabine|DRUG: Paclitaxel|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Embolization in Hereditary Coagulopathies
Status: RECRUITING
Conditions: Hemophilia|Embolization|Hemarthrosis|Clotting Factor Deficiency|Synovitis|Arthropathy
Interventions: DEVICE: embolization with spherical microparticles embosphere
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial
Status: COMPLETED
Conditions: Thoracic Diseases|Postoperative Pain|Opioid Use
Interventions: DRUG: Liposomal bupivacaine|DRUG: Bupivacaine Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin, Capecitabine and Avastin for Metastatic Esophagogastric Adenocarcinoma
Status: COMPLETED
Conditions: Esophageal Neoplasms|Stomach Neoplasms|Neoplasm Metastasis
Interventions: DRUG: capecitabine (Xeloda), oxaliplatin and bevacizumab (Avastin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Empowerment Program Integrated With Family Support on Maternal Self-esteem and Quality of Life Among Palestinian Pregnant Adolescents
Status: COMPLETED
Conditions: Pregnant Adolescents
Interventions: OTHER: Empowered program integrated with family support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER