pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Examining the Feasibility, Acceptability, and Fidelity of Utilizing Parent Training Graduates as Peer Supports
Status: RECRUITING
Conditions: Child Disruptive Behavior Disorders|Parent Child Relationship|Parent Management Training|Peer Support|Child Behavior Problems|Challenging Behavior|Positive Parenting
Interventions: BEHAVIORAL: FAST-B PEERS|BEHAVIORAL: FAST-B (First Approach Skills Training - Behavior)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: PD of VAY736 in Patients With Primary Sjögren's Syndrome
Status: COMPLETED
Conditions: Primary Sjögren's Syndrome
Interventions: DRUG: VAY736|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Using Information Technology to Improve Outcomes for Children Living With Cancer
Status: RECRUITING
Conditions: Cancer
Interventions: BEHAVIORAL: Symptom Monitoring & Systematic Assessment and Reporting System in Young Survivors (SyMon-SAYS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Evaluation of Transcutaneous Electrical Stimulation in Post Stroke Dysphagia
Status: TERMINATED
Conditions: Oropharyngeal Dysphagia|Deglutition Disorders
Interventions: DEVICE: Urostim I stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Environmental Strategies & Behavior Change to Reduce Overeating in Obese Children
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Standard Packard Pediatric Weight Control Program|BEHAVIORAL: Standard Packard Pediatric Weight Control Program plus Home-based advising on environmental changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of BIIB104 in Participants With Cognitive Impairment Associated With Schizophrenia (CIAS)
Status: COMPLETED
Conditions: Cognitive Impairment Associated With Schizophrenia
Interventions: DRUG: BIIB104|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating Pembrolizumab, Trastuzumab and FLOT as Perioperative Treatment of HER2-positive, Localized Esophagogastric Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Esophagogastric Adenocarcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Trastuzumab|DRUG: FLOT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Role of the Duodenum in the Pathogenesis of Insulin Resistance and Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Insulin Resistance and Type 2 Diabetes
Interventions: PROCEDURE: Placement of nasogastric feeding tube|PROCEDURE: Nasojejunal feeding tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Long-term Follow-up Study in Subjects Who Received Voretigene Neparvovec-rzyl (AAV2-hRPE65v2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Inherited Retinal Dystrophy Due to RPE65 Mutations
Interventions: BIOLOGICAL: AAV2-hRPE65v2
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Massage Therapy in a Multisensory Environment for Intellectual Disabilities
Status: COMPLETED
Conditions: Behavior Disturbance|Muscle Hypotonia
Interventions: BEHAVIORAL: Multisensory environment (MSE)|BEHAVIORAL: Massage therapy (MT)|OTHER: Control group|BEHAVIORAL: Massage therapy in multisensory environment (MT-MSE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effects of Clinical Pilates Exercises in Patients With Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Clinical pilates exercise|OTHER: Aerobic exercise|OTHER: Clinical Pilates and Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PRINCE Primary: Integrated GP Care for Persistent Physical Symptoms - a Feasibility & Cluster Randomised Controlled Trial
Status: COMPLETED
Conditions: Persistent Physical Symptoms
Interventions: BEHAVIORAL: Integrated GP Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Preoperative IV Versus Oral Acetaminophen
Status: COMPLETED
Conditions: Pain, Postoperative
Interventions: DRUG: IV Acetaminophen|DRUG: PO Acetaminophen|DRUG: PO Placebo|DRUG: IV Solution Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Levobupivacaine vs Levobupivacaine + Dexmedetomidine Infiltration for Post-tonsillectomy Analgesia and Laryngospasm in Pediatric Patients
Status: COMPLETED
Conditions: Post-tonsillectomy Analgesia|Levobupivacaine
Interventions: DRUG: Levobupivacaine hydrochloride|DRUG: Levobupivacaine Hydrochloride + Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Tiotropium + Olodaterol Versus Inhaled Corticosteroids (ICS) + Long-acting β2-agonists (LABA) Among COPD Patients in Taiwan
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Tiotropium (Tio)|DRUG: Inhaled corticosteroids (ICS)|DRUG: Olodaterol (Olo)|DRUG: Long-acting β2-agonists (LABA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Topical Infliximab in Autoimmune Eyes With Keratoprosthesis
Status: WITHDRAWN
Conditions: Stevens-Johnson Syndrome|Toxic Epidermal Necrolysis (Lyell) Syndrome|Mucous Membrane Pemphigoid
Interventions: DRUG: topical infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study of Durvalumab in Combination With R-CHOP or Lenalidomide Plus R-CHOP in Previously Untreated High-Risk Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse
Interventions: DRUG: Durvalumab|DRUG: Rituximab|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Cyclophosphamide|DRUG: Prednisone|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Staccato Zaleplon Single Dose Pharmacokinetics
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Inhaled placebo|DRUG: Inhaled Zaleplon 0.5 mg|DRUG: Inhaled Zaleplon 1 mg|DRUG: Inhaled Zaleplon 2 mg|DRUG: Inhaled Zaleplon 4 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Follow-Up Study for Safety, Efficacy and Tolerability of Rotigotine in Adolescents With Restless Legs Syndrome
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DRUG: Rotigotine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nattokinase Atherothrombotic Prevention Study
Status: COMPLETED
Conditions: Prevention of Subclinical Atherosclerosis Progression|Prevention of Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: Nattokinase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: TACE Combined With RFA/MV Treatment in Hepatocellular Carcinoma Beyond Milan Criterial
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DEVICE: Transcatheter arterial chemoembolization|DEVICE: radiofrequency ablation/microwave ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Blueberries on Enhancing Insulin Sensitivity in Humans: A Pilot Study
Status: WITHDRAWN
Conditions: Insulin Sensitivity
Interventions: DIETARY_SUPPLEMENT: Blueberry Powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Cognitive Impairment|Aging
Interventions: OTHER: Overground Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: First-in-Human Study of MS201408-0005A as Single Agent and in Combinations
Status: TERMINATED
Conditions: Metastatic or Locally Advanced Unresectable Solid Tumors
Interventions: DRUG: M4112
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zero Ischemia Laparoscopic Radio Frequency Ablation Assisted Enucleation of Renal Cell Carcinoma With T1a Stage
Status: UNKNOWN
Conditions: Renal Cell Carcinoma|Zero Ischemia
Interventions: PROCEDURE: zero ischemia laparoscopic RFA assisted TE|PROCEDURE: ischemia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SAMi Intervention Study to Evaluate Smartwatch Interventions in Persons With MCI and Dementia
Status: COMPLETED
Conditions: Dementia|Mild Cognitive Impairment|Alzheimer Disease|Dementia With Lewy Bodies|Dementia, Vascular|Dementia, Mixed|Dementia Frontotemporal
Interventions: DEVICE: drinking reminder and cognitive task (smartwatch-based application)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effect of Late Na Current Blocker Mexiletine on Giant T-wave Electrical Alternans(STOP-TWA)
Status: RECRUITING
Conditions: Giant T-wave Electrical Alternans
Interventions: DRUG: Mexiletine|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Training on Cardio-respiratory Fitness and Health Related Quality of Life
Status: RECRUITING
Conditions: Hemiplegia, Spastic
Interventions: OTHER: Aerobic training program|OTHER: Selected physical therapy program for post stroke patients
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleep Behavior and Rest-activity Circadian Rhythm (RAR) in Hip/Knee Prosthesis
Status: COMPLETED
Conditions: Sleep|Pain|Hospitalization|Arthroplasty Complications|RAR
Interventions: DEVICE: Objective sleep evaluation by actigraphy|OTHER: Pittsburgh Sleep Quality Index (PSQI)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Strategies to Maintain Radial Artery Patency Following Diagnostic Coronary Angiography - Subgroup of Patients on Oral Anticoagulants
Status: UNKNOWN
Conditions: Patient Undergoing Diagnostic Coronary Angiography
Interventions: OTHER: Distal radial access|OTHER: Distal radial access
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Doxycycline in the Treatment of Aggressive Periodontitis
Status: COMPLETED
Conditions: Aggressive Periodontitis
Interventions: DRUG: amoxicillin plus metronidazole|DRUG: Doxycycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers in DNA Samples From Younger Patients With Newly Diagnosed Acute Myeloid Leukemia Receiving Gemtuzumab Ozogamicin
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: DNA analysis|GENETIC: polymerase chain reaction|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Heat-sensitive Moxibustion Self-administration in Patients in the Community With Primary Hypertension: Protocol for a Multi-center, Pragmatic, Non-randomized Trial
Status: UNKNOWN
Conditions: Primary Hypertension
Interventions: OTHER: Heat-sensitive moxibustion plus antihypertensive drugs|DRUG: Antihypertensive drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Superstructure Material on Crestal Bone Resorption and Esthetic Outcome of Dental Implants
Status: UNKNOWN
Conditions: Single Tooth Dental Implant
Interventions: PROCEDURE: monolithic zirconia crown|PROCEDURE: metal ceramic crown
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity
Status: COMPLETED
Conditions: Cannabis Use Disorder|PREG1|Drug Use|Fetal Exposure During Pregnancy|Neurodevelopmental Abnormality
Interventions: OTHER: no intervention, this is a purely observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Online LTP+CaCBT for Treating Depression in British Mothers of African/Caribbean Heritage
Status: UNKNOWN
Conditions: Postnatal Depression
Interventions: BEHAVIORAL: LTP|BEHAVIORAL: CaCBT|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Chronic Heart Failure and Chronic Obstructive Pulmonary Disease Patients
Status: COMPLETED
Conditions: Cachexia|Chronic Obstructive Pulmonary Disease|Chronic Heart Failure
Interventions: DIETARY_SUPPLEMENT: oral nutrition supplement, food for special medical purposes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: WallFlex Pancreatic Metal Stent for Pancreatic Duct Strictures
Status: COMPLETED
Conditions: Chronic Pancreatitis
Interventions: DEVICE: Pancreatic fully-covered self-expanding metal stent (FCSEMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Occupational Therapy Fatigue Management-Based Intervention for Metastatic Renal Cell Carcinoma
Status: WITHDRAWN
Conditions: Metastatic Renal Cell Carcinoma|Stage IV Renal Cell Cancer AJCC v8
Interventions: BEHAVIORAL: Occupational Therapy|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study Evaluating the Safety and Tolerability of Weekly Dosing of Oral IXAZOMIB in Adult Patients With Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Ixazomib citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate the Safety and Antimicrobial Efficacy of DBI-002 Probiotic in Adults With Tinea Versicolor
Status: COMPLETED
Conditions: Tinea Versicolor
Interventions: BIOLOGICAL: DBI-002 probiotic gel|BIOLOGICAL: Aqueous gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Telehealth Palliative Care Model for Persons With Dementia
Status: COMPLETED
Conditions: Palliative Care|Dementia
Interventions: OTHER: Palliative Care Consultation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Validation of a Diagnostic Method for Quantification of Sleep Bruxism
Status: COMPLETED
Conditions: Sleep Bruxism|Diagnosis
Interventions: DEVICE: DIABRUX
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Determining Change in Cardiovascular and Metabolic Risks in Patients With Chronic Phase Chronic Myeloid Leukemia Receiving BCR-ABL Tyrosine Kinase Inhibitor First-Line Therapy in the United States
Status: COMPLETED
Conditions: Chronic Phase Chronic Myeloid Leukemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery
Status: COMPLETED
Conditions: Valvular Heart Disease
Interventions: DRUG: (Glucose-Insulin-Potassium)GIK group|DRUG: normal saline group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura
Status: ACTIVE_NOT_RECRUITING
Conditions: Thrombotic Thrombocytopenic Purpura
Interventions: DRUG: Caplacizumab|DRUG: Corticosteroids|BIOLOGICAL: anti-CD20 antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interferon Alfa With or Without Interleukin-2 and Fluorouracil in Treating Patients With Advanced Metastatic Kidney Cancer
Status: COMPLETED
Conditions: Kidney Cancer
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: recombinant interferon alfa|DRUG: fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Study of the Aliya System in the Treatment of Early Stage Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Non Small Cell Lung Cancer
Interventions: DEVICE: Pulsed electric field treatment using the Aliya System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pramipexole and Morphine for Renal Colic
Status: COMPLETED
Conditions: Renal Colic
Interventions: DRUG: Pramipexole|DRUG: Morphine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simplified vs. Conventional Methods for Complete Denture Fabrication
Status: COMPLETED
Conditions: Edentulous Mouth|Edentulous Jaw
Interventions: PROCEDURE: Denture fabrication technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: The Multi-Ethnic Lifestyle Study
Status: UNKNOWN
Conditions: Diabetes Mellitus|Chronic Kidney Diseases|Cardiovascular Diseases|Obstructive Sleep Apnea|Respiratory Disease|Cancer|Stroke|Chronic Pain|Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)|Healthy
Interventions: BEHAVIORAL: No intervention
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Research of Standard Diagnosis and Treatment for Severe HSP in Children
Status: UNKNOWN
Conditions: Henoch-Schoenlein Purpura
Interventions: DRUG: Dexamethasone|DRUG: Gamma globulin|PROCEDURE: Hemoperfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pragmatic Research of Acupuncture and Counseling eXtended to Inpatient Services
Status: COMPLETED
Conditions: Malignant Solid Tumor|Pain
Interventions: PROCEDURE: Acupuncture|BEHAVIORAL: Pain Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants
Status: COMPLETED
Conditions: β-thalassemia Major
Interventions: GENETIC: LentiGlobin BB305 Drug Product
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HCV Treatment Immune Response With Grazoprevir/Elbasvir Before or After Renal Transplant
Status: COMPLETED
Conditions: Hepatitis C|Renal Insufficiency, Chronic|Disorder of Transplanted Kidney
Interventions: DRUG: Post-transplant Grazoprevir and Elbasvir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Boston Scientific's Single Shot LUMINIZE RF Balloon Catheter in the Treatment of Symptomatic, Drug Refractory Paroxysmal Atrial Fibrillation
Status: WITHDRAWN
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: LUMINIZE RF Balloon Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates
Status: TERMINATED
Conditions: Corneal Infiltrates
Interventions: DRUG: Moxifloxacin/dexamethasone phosphate ophthalmic solution|DRUG: Moxifloxacin ophthalmic solution 0.5%|DRUG: Dexamethasone phosphate solution, 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life After Esophagectomy for Cancer - Step 1
Status: TERMINATED
Conditions: Esophageal Cancer|Sleep Disturbance|Quality of Life
Interventions: BEHAVIORAL: psychological counseling|BEHAVIORAL: prevention of sleep disorders in ICU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AI
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant|DRUG: Everolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial of DP-R206 and Bonvia In Postmenopausal Women With Osteoporosis
Status: COMPLETED
Conditions: Postmenopausal Women With Osteoporosis
Interventions: DRUG: Test group|DRUG: Reference group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Canagliflozin (TA-7284)|DRUG: Placebo|DRUG: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of Intravenous (IV) Infusion of MTP-131 (Bendavia™) in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: MTP-131 (Bendavia™)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of rTMS Treatment on Alzheimer's and Sleep Quality
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DEVICE: rTMS real-sham|DEVICE: rTMS sham-real
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Wear Characteristics and Clinical Performance of Lithium Silicate Versus Monolithic Zirconia Crowns.
Status: UNKNOWN
Conditions: Enamel and Ceramics Wear
Interventions: OTHER: monolithic zirconia crowns|OTHER: lithium silicate crowns
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Tumour 1q Gain in French Pediatric and Young Adult Patients With Renal Tumours
Status: NOT_YET_RECRUITING
Conditions: Kidney Cancer
Interventions: OTHER: Radiologic Centralized Review|OTHER: Tissue sample (tumor, sung, urine)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Laboratory-Treated (Central Memory/Naive) CD8+ T Cells in Treating Patients With Newly Diagnosed or Relapsed Acute Myeloid Leukemia
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|EBV-Positive Neoplastic Cells Present|HLA-A*0201 Positive Cells Present|Blasts Under 5 Percent of Bone Marrow Nucleated Cells|Elevated WT1
Interventions: BIOLOGICAL: Aldesleukin|BIOLOGICAL: Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty
Status: TERMINATED
Conditions: Pain, Postoperative
Interventions: DRUG: Dextromethorphan|DRUG: Placebo - Concentrate|DRUG: Acetaminophen|DRUG: Oxycodone|DRUG: Celecoxib|DRUG: Pantoprazole|DRUG: Ketorolac|DRUG: Gabapentin|DRUG: Hydromorphone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease
Status: COMPLETED
Conditions: Breast Cancer|Hot Flashes|Hot Flushes
Interventions: DIETARY_SUPPLEMENT: soy protein|DIETARY_SUPPLEMENT: isoflavones|DRUG: Tamoxifen|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Naltrexone for Prolonged Grief Disorder
Status: RECRUITING
Conditions: Naltrexone HCl 50 MG Oral Tablet|Placebo
Interventions: DRUG: Naltrexone Oral Product|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)
Status: WITHDRAWN
Conditions: Fibrodyplasia Ossificans Progressiva (FOP)|Heterotopic Ossification (HO)
Interventions: DRUG: garetosmab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Intracranial Hemorrhages
Interventions: DRUG: Phenobarbital|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Treatment of Refractory Chronic Cough With PA101
Status: COMPLETED
Conditions: Refractory Chronic Cough
Interventions: DRUG: PA101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antiglucocorticoid Augmentation of antiDepressants in Depression
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Metyrapone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
Status: ENROLLING_BY_INVITATION
Conditions: Hypertrophic Cardiomyopathy|Hypertrophic Obstructive Cardiomyopathy|Familial Hypertrophic Cardiomyopathy|Cardiomyopathies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: MASA Valve Early Feasibility Study
Status: RECRUITING
Conditions: Tetrology of Fallot|Pulmonary Stenosis|Truncus Arteriosus|Transposition of Great Vessels|Pulmonary Atresia|Ross Procedure
Interventions: DEVICE: Surgical Right Ventricular Outflow Tract Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Le Kip Kip: A Campaign to Change Social Norms and Build Sustainable Demand for PrEP Among Women in South Africa
Status: COMPLETED
Conditions: Pre-exposure Prophylaxis|HIV Infections
Interventions: BEHAVIORAL: Social Media Campaign|BEHAVIORAL: PrEP Champions|BEHAVIORAL: Community Mobilization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: To Test for Photo Allergy Reaction of Sunscreens
Status: COMPLETED
Conditions: Photoallergy
Interventions: DRUG: SPF 50 Y65 110 (BAY987519)|DRUG: SPF 50 Y51 002 (BAY987519)|DRUG: SPF 15 V27 104 (BAY987519)|DRUG: Sodium chloride [NaCl]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: The Use of Myocardial Deformation Imaging
Status: COMPLETED
Conditions: Myocardial Viability in Ischemic Left Ventricular Dysfunction|Prediction for Improvement in Cardiac Function After Revascularization Therapy
Interventions: PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Revascularization|PROCEDURE: Echocardiography with myocardial deformation imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients
Status: TERMINATED
Conditions: Covid19|Appendicitis|Cholecystitis, Acute|Cholecystitis; Gallstone|Cholecystitis
Interventions: PROCEDURE: Operative management|PROCEDURE: Non-operative management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optical Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Basal Cell Carcinoma
Interventions: DEVICE: Reflectance ConfocaL Microscopy And Optical Coherence Tomography Guided|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Finding an Optimal Latency for Paired Associative Stimulation in People With Chronic Stroke
Status: UNKNOWN
Conditions: Stroke
Interventions: DEVICE: Transcranial Magnetic Stimulation (Magstim)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Tolerability of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Renal Transplant Patients With GI Intolerance
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-coated mycophenolate sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Clinical Trial of Intravenous Sodium Thiosulfate in Acute Calciphylaxis Patients
Status: TERMINATED
Conditions: Calciphylaxis
Interventions: DRUG: Sodium Thiosulfate|DRUG: Placebo-Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Equivalence Study of Fluticasone Propionate Nasal Spray, 50 mcg/Actuation vs. Flonase in Allergic Rhinitis Patients
Status: TERMINATED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Fluticasone propionate|DRUG: Flonase®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC) in Patients With Stable Type 2 Diabetes and Hypertension
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: DRUG: IW-1973|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Life-style Changes in Obstructive Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive|Obesity
Interventions: BEHAVIORAL: Behavioural strategies to promote physical activity and weight loss|DEVICE: CPAP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE-
Status: COMPLETED
Conditions: Colorectal Serrated Adenomas|Colorectal Tubular Adenomas|Colorectal Villous Adenomas|Colorectal Tubulovillous Adenomas
Interventions: DIETARY_SUPPLEMENT: Green tea extract of Camellia Sinensis|DIETARY_SUPPLEMENT: Green tea extract of Camellia Sinensis followed by placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination
Status: COMPLETED
Conditions: Diphtheria|Pertussis|Tetanus|Hepatitis B|Haemophilus Infections
Interventions: BIOLOGICAL: Quinvaxem|BIOLOGICAL: Quinvaxem/Tritanrix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Cost-effectiveness of a Transdiagnostic Psychological Treatment for Emotional Disorders in Primary Care
Status: UNKNOWN
Conditions: Emotional Disorder
Interventions: BEHAVIORAL: Transdiagnostic cognitive-behavioral therapy (TD-CBT)|BEHAVIORAL: Bernstein and Borkovec progressive muscle relaxation (PMR)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: GW572016 and Trastuzumab in Treating Patients With Metastatic Breast Cancer That Overexpresses HER2/Neu
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: lapatinib ditosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Total Marrow Irradiation With Volumetric Arc Therapy for Patients Unfit for a 12 Gy TBI
Status: RECRUITING
Conditions: Haematological Malignancy
Interventions: RADIATION: Volumetric Arc Therapy (VMAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NEPA Combined With Olanzapine, Dexamethasone-sparing for the Effect of CINV in Patients Receiving HEC Regimens
Status: NOT_YET_RECRUITING
Conditions: Chemotherapy-induced Nausea and Vomiting|Highly Emetogenic Chemotherapy
Interventions: DRUG: Netupitant / Palonosetron Oral Capsule [Akynzeo]|DRUG: Olanzapine|DRUG: Dexamethasone Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: An Exploratory Study of the Folic Acid-tubulysin Conjugate EC1456 in Ovarian Cancer Subjects Undergoing Surgery
Status: COMPLETED
Conditions: Ovary Cancer
Interventions: DRUG: EC1456|DRUG: 99mTc-Etarfolatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effectiveness of BioFoam® Surgical Matrix to Improve Hemostasis During Liver Resection
Status: COMPLETED
Conditions: Hemorrhage
Interventions: PROCEDURE: BioFoam® Surgical Matrix|OTHER: Conservative hemostasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adult Acute Lymphoblastic Leukemia Treated With Pediatric Regimen in Brazil
Status: RECRUITING
Conditions: Acute Lymphoid Leukemia|Minimal Residual Disease|Gene Abnormality|Chemotherapeutic Toxicity
Interventions: DRUG: Prednisone|DRUG: Vincristin|DRUG: Daunorubicin|DRUG: Peg-asparaginase|DRUG: Intrathecal Suspension|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Doxorubicin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety, Tolerability, and Pharmacokinetics (PK) of Single and Multiple Ascending Oral Doses of XEN1101.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: XPF-008|DRUG: Microcrystalline Cellulose|DRUG: XPF-010|DRUG: Itraconazole 400mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation Health Literacy and Information Technology Trial in Rural Pennsylvania Counties
Status: COMPLETED
Conditions: Atrial Fibrillation|Familial Atrial Fibrillation|Arrhythmia, Cardiac|Heart Diseases|Pathologic Processes
Interventions: BEHAVIORAL: Relational agent/AliveCor Kardia - Intervention|BEHAVIORAL: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study to Investigate the Safety, Tolerability, Food Effect, Pharmacokinetics and Pharmacodynamics of FOR-6219
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Placebo|DRUG: FOR-6219
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adaptation and Pilot Testing of a Mindfulness-Based Insomnia and Symptom Management Intervention for Women With Breast Cancer Receiving Treatment in Rural Medically Underserved Areas
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Mindfulness-Based Therapy for Insomnia with Cognitive-Behavioral Symptom Coping Skills
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Novel Fluoride Varnish in Preventing WSL During/After Treatment With Fixed Orthodontic Appliances
Status: UNKNOWN
Conditions: Orthodontic Appliance Complication
Interventions: OTHER: Fluoride varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Use of Joystick-operated Ride-on-toys to Improve Affected Arm Use and Function in Children With Hemiplegic Cerebral Palsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemiplegic Cerebral Palsy
Interventions: DEVICE: Ride-on-toy navigation training|BEHAVIORAL: Upper extremity functional training
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Intervention to Improve Communication Between Physicians and Minority Patients With Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: BEHAVIORAL: Self-affirmation exercise|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Phase I Study of Continuous Infusion Schedule of FMdC in Hematologic Malignancies
Status: COMPLETED
Conditions: Hematologic Malignancies
Interventions: DRUG: Tezacitabine (FMdC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)
Status: TERMINATED
Conditions: Hereditary Hemorrhagic Telangiectasia|Epistaxis
Interventions: DRUG: Bevacizumab|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cetuximab Plus Radiotherapy Versus Cisplatin Plus Radiotherapy in Locally Advanced Head and Neck Cancer
Status: TERMINATED
Conditions: Head and Neck Neoplasms|Laryngeal Neoplasms|Mouth Neoplasms|Pharyngeal Neoplasms
Interventions: DRUG: cetuximab|DRUG: cisplatin (associated to radiotherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Clinical Trial of 13-valent Pneumococcal Conjugate Vaccine (Multivalent Conjugate) in Infants
Status: RECRUITING
Conditions: Streptococcus Pneumoniae Infection
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine (multivalent conjugate)|BIOLOGICAL: Prevenar 13
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: GXR RM (Glucophage® Extended Release Reduced Mass) 500 Milligram (mg) Korea Bioequivalence (BE) Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Glucophage® XR RM Test|DRUG: Glucophage® XR Reference
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Assess the Oral Bioavailability of a New ABT-263 Formulation in Healthy Female Subjects
Status: COMPLETED
Conditions: Healthy Female Subjects
Interventions: DRUG: ABT-263|DRUG: ABT-263|DRUG: ABT-263
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Vaginal Hyaluronic Acid, Arginine and Liposome Gel Versus Vaginal Lubricant in Postmenopausal Women With Genitourinary Syndrome of Menopause
Status: NOT_YET_RECRUITING
Conditions: Menopause Related Conditions|Atrophic Vaginitis|Genitourinary Syndrome of Menopause|Sexual Dysfunction
Interventions: DRUG: Vaginal Gel|DRUG: Vaginal lubricant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine Plus Cytarabine Versus Conventional Induction Therapy And A Study Of NK Cell Transplantation In Newly Diagnosed Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cytarabine|DRUG: Daunorubicin|DRUG: Etoposide|DRUG: Clofarabine|DEVICE: CliniMACS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gazyvaro and Low Dose Radiotherapy in Early Stage Follicular Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage II Grade 1 Follicular Lymphoma|Stage II Grade 2 Follicular Lymphoma|Stage I Follicular Lymphoma Grade 1|Stage II Follicular Lymphoma Grade 2
Interventions: DRUG: Obinutuzumab Injection [Gazyva]|RADIATION: Low dose radiation Therapy (LDRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Double-blinded Randomised Comparison of Profix Mobile to Fixed Bearing Knee Replacements
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Fixed bearing prosthesis|DEVICE: Mobile bearing prosthesis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration (LIGHTSITE II)
Status: COMPLETED
Conditions: Dry Age-related Macular Degeneration
Interventions: DEVICE: Valeda PBM treatment|DEVICE: Valeda Sham treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Grafix® DFU: Open-Label Extension Option to Evaluate Safety & Efficacy of Grafix® for Chronic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: OTHER: Tissue|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Topical Tranexamic Acid for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Surgical Blood Loss|Total Knee Arthroplasty
Interventions: DRUG: tranexamic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION