pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: The Influence of Neuromuscular Training on Whole-body Movement Strategies and Knee Mechanics During Change-of-direction Tasks in Sports Science Students
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Interventions: BEHAVIORAL: FIFA11+ and multidirectional training (MD)|BEHAVIORAL: FIFA11+ and linear sprint training (MD)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Performance of SYMMCORA® vs. V-Loc® Suture Material in Patients Undergoing Laparoscopic Total Hysterectomy
Status: RECRUITING
Conditions: Abnormal Uterine Bleeding|Endometriosis|Uterine Prolapse|Uterine Cancer|Ovarian Cancer|Fallopian Tube Cancer|Cervical Cancer|Endometrial Cancer
Interventions: DEVICE: Closure of the Vaginal Cuff after Total Hysterectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Piperacillin Sodium and Sulbactam Sodium for Injection(2:1) for Treatment of Respiratory and Urinary System Infection
Status: COMPLETED
Conditions: Respiratory Tract Infections|Urinary Tract Infections
Interventions: DRUG: Piperacillin Sodium and Sulbactam Sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Isatuximab During Stem Cell Collection and Transplant in Patients With Multiple Myeloma and Lymphoma
Status: RECRUITING
Conditions: Lymphoma|Multiple Myeloma|Non-Hodgkin Lymphoma|Relapsed Hodgkin's Disease, Adult
Interventions: DRUG: Isatuximab|OTHER: Standard Procedures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Blended and Problem-based Learning to Improve the Competence of Geriatric Nursing Students
Status: UNKNOWN
Conditions: Narrative Ethics
Interventions: OTHER: The protocol of blended and problem-based learning|OTHER: The traditional problem-oriented teaching model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Effect of Colchicine on MMP-9, NOX2, and TGF-β1 in Myocardial Infarct
Status: RECRUITING
Conditions: ST Elevation Myocardial Infarction|Colchicine|Cardiac Remodeling, Ventricular
Interventions: DRUG: Colchicine|PROCEDURE: Percutaneous Coronary Intervention|OTHER: Optimal medical treatment including statin, aspirin, P2Y12 inhibitor, and nitrate.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-In-Man Performance and Safety Evaluation of the CARLO® Device in Midface Osteotomies
Status: COMPLETED
Conditions: Abnormalities, Jaw|Malocclusion, Angle Class III
Interventions: DEVICE: Mid-face osteotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy
Status: COMPLETED
Conditions: Palliative Care|Pain|Cancer
Interventions: DRUG: Placebo|DRUG: Sativex®|DRUG: THC Alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Preliminary Clinical Study on the Pharmacokinetics and Safety of CDP1 in Patients With Advanced CRC or HNSCC
Status: UNKNOWN
Conditions: Colorectal Cancer
Interventions: DRUG: anti-EGFR monoclonal antibody|DRUG: Cetuximab injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Extensive-stage Small Cell Lung Cancer
Status: RECRUITING
Conditions: Extensive-stage Small-cell Lung Cancer
Interventions: DRUG: BL-B01D1|DRUG: PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sunvozertinib Plus Anlotinib as 1L Treatment in EGFR Mutant Advanced NSCLC-RW
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: sunvozertinib in combination with Anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of ONO-7914 Alone and in Combination With ONO-4538 in Patients With Solid Tumors
Status: RECRUITING
Conditions: Solid Tumor
Interventions: DRUG: ONO-7914|DRUG: ONO-4538
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Alfacalcidol on Falls in Osteopenic/Osteoporotic Postmenopausal Women (ALFA Study)
Status: COMPLETED
Conditions: Osteoporosis, Postmenopausal|Osteopenia|Falls
Interventions: DRUG: alfacalcidol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anlotinib Plus Docetaxel for the Treatment of EGFR Wild-type Advanced Non-small-cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Anlotinib Plus Docetaxel|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fecal Microbiota Transplant for Patients With Chronic Pouchitis
Status: RECRUITING
Conditions: Chronic Pouchitis|Pouchitis
Interventions: DRUG: Fecal Microbiota Transplant (FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Relieves Anxiety, Depression and Sleep Disorderes in Patients With Blepharospasm
Status: UNKNOWN
Conditions: Blepharospasm
Interventions: DRUG: Botulinum toxin type A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LEO 27847 - Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in Secondary Hyperparathyroidism Patients
Status: COMPLETED
Conditions: Secondary Hyperparathyroidism
Interventions: DRUG: LEO 27847
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Study of Metoclopramide in Small Bowel Capsule Endoscopy
Status: COMPLETED
Conditions: Pill Capsule Endoscopy Completion Rates
Interventions: DRUG: Metoclopramide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Dexamethasone and Analgesic Duration After Supraclavicular Brachial Plexus Blockade
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Dexamethasone|DRUG: Mepivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring and Modulating Changes in EEG Resting State Functional Connectivity During Short-term and Long-term Pain
Status: COMPLETED
Conditions: Prolonged Pain, EEG, Resting State Functional Connectivity
Interventions: OTHER: 8% Capsaicin patch|OTHER: placebo patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Testosterone vs Placebo in Testicular Cancer Survivors
Status: COMPLETED
Conditions: Metabolic Syndrome|Testicular Cancer|Leydig Cell Failure in Adult
Interventions: DRUG: Testosterone|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intramuscular Heating Rates of a Chattanooga Intelect XT Therapeutic Ultrasound
Status: COMPLETED
Conditions: Ultrasound Therapy; Complications
Interventions: DEVICE: Therapeutic Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective, Cross-sectional and Multicenter Study, Evaluating the Diagnosis Accuracy of the Controlled Attenuation Parameter(CAP) Measured by FibroScan® (Either With M+ or XL+ Probe) in Patient With Non-Alcoholic Fatty Liver Disease Using Liver Biopsy as Reference.
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DEVICE: FibroScan® examination.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Effect of Platelet-Rich Plasma-Fibrin Glue in Combination With Vitamin E and C for Treatment of Non-healing Diabetic Foot Ulcers
Status: UNKNOWN
Conditions: Diabetic Foot Ulcers|Diabetic Wound
Interventions: DRUG: PRP-Fibrin Glue|DIETARY_SUPPLEMENT: Vitamin E and C|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FDG PET and DCE-MRI in Predicting Response to Treatment in Patients With Breast Cancer
Status: TERMINATED
Conditions: Male Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer
Interventions: RADIATION: fludeoxyglucose F 18|DEVICE: positron emission tomography|DEVICE: dynamic contrast-enhanced magnetic resonance imaging|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Nutrient Delivery Pattern on Biological Rhythms in Human Skeletal Muscle
Status: COMPLETED
Conditions: Circadian Rhythms|Feeding Patterns
Interventions: OTHER: Constant|OTHER: Bolus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Therapeutic Exercise on the Activation of the Neck Extensors in People With Chronic Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: PROCEDURE: Static exercise for emphasized neck extensors|PROCEDURE: Dynamic exercise for emphasized neck extensors|PROCEDURE: Static exercise for general neck extensors|PROCEDURE: Dynamic exercise for general neck extensors
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Saline Irrigation Reduces the Residual Bile Duct Stones During Endoscopic Retrograde Cholangiopancreatography (ERCP)
Status: COMPLETED
Conditions: Stone Clearance
Interventions: PROCEDURE: CBD stone removal via lithotripsy|PROCEDURE: Saline 50ml|PROCEDURE: Saline +50ml
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: EMST in Patients Undergoing CRT for HNCA
Status: RECRUITING
Conditions: Head and Neck Neoplasms|Deglutition Disorders
Interventions: OTHER: EMST
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Goal-directed Hemodynamic Therapy in Patiens Undergoing Major Hepatic Resection
Status: COMPLETED
Conditions: Hemodynamic Monitoring
Interventions: PROCEDURE: Goal-directed hemodynamic therapy|PROCEDURE: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Lung Cancer
Interventions: DRUG: cisplatin|DRUG: mitomycin C|DRUG: vinblastine sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Phenelzine Sulfate in Treating Patients With Non-metastatic Recurrent Prostate Cancer
Status: COMPLETED
Conditions: Adenocarcinoma of the Prostate|Recurrent Prostate Cancer|Stage I Prostate Cancer|Stage IIA Prostate Cancer|Stage IIB Prostate Cancer|Stage III Prostate Cancer
Interventions: DRUG: phenelzine sulfate|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of APX-115 in Hospitalized Patients With Confirmed Mild to Moderate COVID-19.
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: APX-115|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A6 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Status: COMPLETED
Conditions: Fallopian Tube Carcinoma|Malignant Ovarian Mixed Epithelial Tumor|Ovarian Brenner Tumor|Ovarian Clear Cell Cystadenocarcinoma|Ovarian Endometrioid Adenocarcinoma|Ovarian Mucinous Cystadenocarcinoma|Ovarian Serous Cystadenocarcinoma|Primary Peritoneal Carcinoma|Recurrent Ovarian Carcinoma|Undifferentiated Ovarian Carcinoma
Interventions: BIOLOGICAL: Urokinase-Derived Peptide A6|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion
Status: TERMINATED
Conditions: Malignant Pleural Effusion|Stage IV Metastatic Cancer|Lung Cancer
Interventions: DRUG: Talimogene laherparepvec (TVEC)|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcomes of Laparoscopic D1 Versus D2 Lymphadenectomy for Elderly Patients With Advanced Gastric Cancer
Status: UNKNOWN
Conditions: Stomach Neoplasm
Interventions: PROCEDURE: Laparoscopic D1 Lymphadenectomy|PROCEDURE: Laparoscopic D2 Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: G-Step: Gemcitabine Based Small-cell Lung Cancer Treatment in Elderly Patients
Status: COMPLETED
Conditions: Small Cell Lung Cancer
Interventions: DRUG: gemcitabine|DRUG: vinorelbine|DRUG: cisplatin|DRUG: etoposide|DRUG: carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pharmacokinetic/Pharmacodynamic Study of Oseltamivir in Immunocompromised Children With Confirmed Influenza Infection
Status: COMPLETED
Conditions: Influenza
Interventions: DRUG: Oseltamivir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels
Status: COMPLETED
Conditions: Bipolar Affective Disorders|Cyclothymic Disorder|Schizoaffective Disorder|Major Depressive Disorder|Dysthymic Disorder|Obsessive-Compulsive Disorder|Panic Disorder|Posttraumatic Stress Disorder|Premenstrual Dysphoric Disorder|Social Anxiety Disorder
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Tiotropium 2.5 and 5 µg Once Daily Delivered Via the Respimat Inhaler Compared to Placebo in Patient With Moderate to Severe Persistent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Tiotropium Respimat|DRUG: Placebo Respimat|DRUG: Tiotropium Respimat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: PENG Block Versus LP Block for THA Postop Pain
Status: COMPLETED
Conditions: Pain, Postoperative|Hip Pain Chronic
Interventions: DRUG: Peri-capsular Nerve Group (PENG)|OTHER: Lumbar Plexus Block (LPB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0032|DRUG: Itraconazole|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Catheter-directed Sclerotherapy Versus Surgical Resecction: Randomized Controlled Trial Comparing Ovarian Function and Therapeutic Efficacy After Treatment of Ovarian Endometrioma
Status: UNKNOWN
Conditions: Ovarian Endometrioma
Interventions: PROCEDURE: catheter-directed sclerotherapy|PROCEDURE: surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Survey of QRS Frequency at Various Left Ventricular Pacing Sites for Cardiac Resynchronization
Status: TERMINATED
Conditions: Cardiomyopathies|Congestive Heart Failure
Interventions: DEVICE: Biotronik Vision Guidewire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment
Status: NOT_YET_RECRUITING
Conditions: Adverse Effect
Interventions: DRUG: Norepinephrine|DRUG: Phenylephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Local Excision of Clinical T3 Rectal Adenocarcinoma Showing Major Response(ycT0-1) After Neoadjuvant Chemoradiotherapy
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: PROCEDURE: Local excision
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Benralizumab in Patients With Eosinophilic Esophagitis
Status: TERMINATED
Conditions: Eosinophilic Esophagitis
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Open-label Study to Evaluate the Effectiveness of an Intramuscular Formulation of Aripiprazole (OPC-14597) as Maintenance Treatment in Patients With Bipolar I Disorder
Status: COMPLETED
Conditions: Bipolar I
Interventions: DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients
Status: COMPLETED
Conditions: Obstructive Sleep Apnea|Overhydration|End Stage Renal Disease
Interventions: PROCEDURE: Hemodialysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Compare Continuous Gastrocnemius Plane Block With Intravenous Analgesia After Foot and Ankle Surgery
Status: UNKNOWN
Conditions: Foot Ankle Injuries
Interventions: DRUG: Continuous Gastrocnemius plane block with ropivacaine|DRUG: oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection
Status: COMPLETED
Conditions: Endoplasmic Reticulum Stress|Viral Infection|Yellow Fever
Interventions: DRUG: Metformin Hydrochloride|DRUG: Calcium and Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hepatitis C Treatment to Prevent HIV, Initiate Opioid Substitution Therapy, and Reduce Risky Behavior
Status: ACTIVE_NOT_RECRUITING
Conditions: HCV|Buprenorphine|PreP
Interventions: OTHER: Evaluate model of care for HCV-infected adults with on-going opioid misuse
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploratory Study of Irinotecan Liposomes in Maintenance Therapy of Metastatic Colorectal Cancer
Status: NOT_YET_RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Irinotecan Liposome|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prophylactic Funnel Mesh to Prevent Parastomal Hernia in Permanent End Colostomy After Abdomino-perineal Resection
Status: COMPLETED
Conditions: Hernia|Colostomy Stoma
Interventions: DEVICE: funnel-shaped, intraperitoneal mesh placement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sentinel Node Biopsy Alone or With Axillary Dissection After Primary Chemotherapy
Status: COMPLETED
Conditions: Breast Neoplasm Female
Interventions: PROCEDURE: Sentinel Node Biopsy|PROCEDURE: Axillary Dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label, Healthy Volunteers, Bioequivalence Study With Naloxegol
Status: COMPLETED
Conditions: Opioid Induced Constipation
Interventions: DRUG: Naloxegol|DRUG: Naloxegol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Antimicrobial Stewardship Interventions in a Hospital Setting
Status: COMPLETED
Conditions: Infectious Disease
Interventions: OTHER: Implementation of prospective audit and feedback stewardship interventions to reduce unnecessary use of antimicrobials and improve quality of prescriptions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Safety of HPV Vaccine in Women (V501-011)(COMPLETED)
Status: COMPLETED
Conditions: Cervical Cancer|Genital Warts
Interventions: BIOLOGICAL: V501, Gardasil, Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine / Duration of Treatment : 4 Years|BIOLOGICAL: Comparator: placebo (concomitant-vaccine matched) / Duration of Treatment : 4 Years
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Enhanced Recovery After Laparoscopic Sleeve Gastrectomy - a Randomised Controlled Trial
Status: COMPLETED
Conditions: Morbid Obesity
Interventions: OTHER: Enhanced Recovery After Surgey for Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of PRO044 in Duchenne Muscular Dystrophy (DMD)
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: PRO044 SC|DRUG: PRO044 IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intravenous Dexmedetomidine Versus Dexamethasone for Management of Repound Pain After Supraclavicular Brachial Plexus Block
Status: NOT_YET_RECRUITING
Conditions: Trauma Injury
Interventions: DRUG: Dexmedetomidine injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab
Status: RECRUITING
Conditions: Glioma|Glioblastoma Multiforme
Interventions: DRUG: APG-157
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient and Provider Interventions for Managing Osteoarthritis in Primary Care
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: BEHAVIORAL: Patient Behavioral Intervention for OA|BEHAVIORAL: Provider Intervention for OA|BEHAVIORAL: Combined Patient and Provider Interventions for OA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039)
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: Omarigliptin|DRUG: Placebo|BIOLOGICAL: Insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic Trial to Validate the Use of the E-Nose in Pulmonary TB
Status: UNKNOWN
Conditions: Tuberculosis, Pulmonary|e-Nose
Interventions: DEVICE: E-Nose|OTHER: Survey & Physical Exam|OTHER: Chest X-ray|OTHER: Sputum Samples|DEVICE: Follow Up 5 days after beginning of Tx.|DEVICE: Follow Up 15 days after beginning of Tx.|DEVICE: Follow Up 30 days after beginning of Tx.|DEVICE: Follow Up 60 days after beginning of Tx.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Gemcitabine, Carboplatin, and Panitumumab (GCaP) as Neoadjuvant Chemotherapy in Patients With Muscle-Invasive Bladder Cancer
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Gemcitabine|DRUG: Carboplatin|DRUG: Panitumumab|PROCEDURE: radical cystectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Posterior Capsule Stretching and Posterior Mobilization on Subacromial Impingement Syndrome
Status: COMPLETED
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Posterior mobilisation technique|OTHER: Posterior capsule stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Haemodialysis on the Pharmacokinetics of Ezogabine/Retigabine and Its N-acetyl Metabolite
Status: COMPLETED
Conditions: Epilepsy
Interventions: DRUG: Retigabine / Ezogabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Deep Brain Stimulation on Motor, Mood, and Cognitive Symptoms in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: PROCEDURE: DBS of the STN|PROCEDURE: DBS of the GPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Brief Family Involved Treatment Telehealth
Status: RECRUITING
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Brief Family-Involved Treatment (B-FIT)|BEHAVIORAL: Cognitive Behavioral Therapy for Alcohol Use Disorder (CBT for AUD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Autoimmune Destruction and Rejection of Human Pancreatic Islets Following Transplantation for Insulin Dependent Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: Belatacept and Raptiva
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label, Multi-center, Expanded Access Study of Everolimus in Participants With Advanced Neuroendocrine Tumors (NETs) (Core Study) and an Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced NETs (E1)
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Whole Cell Algae Fermentate on Gut Health and Overall Immune Function in Healthy Adults With Mild Gastrointestinal Issues
Status: COMPLETED
Conditions: Healthy|Gastrointestinal Dysfunction|Cold Symptom|Flu Symptom
Interventions: DIETARY_SUPPLEMENT: Whole Cell Algae Fermentate|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effect of ASV and DCV Therapy on the Quality of Immune Status in Chronic HCV Patients
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Daclatasvir|DRUG: asunaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: DMID 23-0015; Lassa Fever CVD 1000
Status: NOT_YET_RECRUITING
Conditions: Lassa Fever
Interventions: BIOLOGICAL: LASSARAB+ aPHAD-SEat 700rU|BIOLOGICAL: HDCV Comparator|OTHER: Normal Saline Placebo|BIOLOGICAL: LASSARAB+ aPHAD-SEat 1400rU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Erenumab (AMG 334) in Women With Hot Flashes
Status: COMPLETED
Conditions: Vasomotor Symptoms; Hot Flashes
Interventions: BIOLOGICAL: Erenumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Non-invasive Glioma Characterization Through Molecular Imaging
Status: RECRUITING
Conditions: Glioma|Brain Tumor|Primary Brain Tumor|Malignant Glioma|Malignant Primary Brain Tumor
Interventions: DEVICE: 3T MRI Scanner
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Random Comparison of LigaSure and Disposable Staples for Laparoscopic Surgery
Status: COMPLETED
Conditions: Colonic Diseases|Rectal Diseases
Interventions: PROCEDURE: Bipolar electrosurgical generator and instruments|PROCEDURE: Disposable stapling instruments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Somatic Dysfunction of the Pelvis, Sacrum and Lower Lumbar Spine on Weight Bearing
Status: COMPLETED
Conditions: Somatic Dysfunctions of Pelvis|Somatic Dysfunctions of Sacrum|Somatic Dysfunctions of Lower Lumbar Spine|Weight-Bearing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in PID Patients
Status: COMPLETED
Conditions: Primary Immunodeficiency Disease
Interventions: BIOLOGICAL: Kedrion IVIG 10%
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety of and Immune Response to an HIV Vaccine in Healthy, HIV-Uninfected Adults in Uganda
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: VRC-HIVADV014-00-VP Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Ranolazine on CPET Parameters in Ischemic Cardiomyopathy Patients (ERIC)
Status: TERMINATED
Conditions: Cardiomyopathy
Interventions: DRUG: Ranolazine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
Status: COMPLETED
Conditions: Cocaine Dependence|Depression
Interventions: OTHER: Placebo|DRUG: Mirtazapine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: TMC278-TiDP6-C152: A Study to Assess the Effects of TMC278 and Efavirenz (EFV) on the QT/QTc Interval (Heart Conduction and Heart Rhythm) in Healthy Volunteers.
Status: COMPLETED
Conditions: Human Volunteers
Interventions: DRUG: TMC278; Moxifloxacin; Efavirenz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Comparison of Low and Conventional Irradiance PDT for Skin Cancer
Status: COMPLETED
Conditions: Non-melanoma Skin Cancer
Interventions: DEVICE: Ambulight (Ambicare Health)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Videoscopic Ilioinguinal Lymphadenectomy for Melanoma
Status: COMPLETED
Conditions: Melanoma|Secondary Malignant Neoplasm of Lymph Node
Interventions: PROCEDURE: Videoscopic ilioinguinal dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Back to the Future: Bridging the Hospital to Home Continuum After Hip Fracture
Status: COMPLETED
Conditions: Hip Fracture
Interventions: BEHAVIORAL: Telephone Support and Coaching|BEHAVIORAL: Education Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease
Status: RECRUITING
Conditions: Chronic Granulomatous Disease (CGD)|X-Linked Chronic Granulomatous Disease
Interventions: BIOLOGICAL: Base-edited hematopoietic stem and progenitor cells|DRUG: Busulfan|DRUG: Palifermin|DRUG: Filgrastim|DRUG: Plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Post-Operative Pain and Recovery in Gynecologic Surgery
Status: COMPLETED
Conditions: Postoperative Pain|Opioid Use|Acetaminophen
Interventions: DRUG: Rectal acetaminophen|DRUG: Intravenous acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers
Status: COMPLETED
Conditions: MELAS Syndrome|Mitochondrial Respiratory Chain Deficiencies
Interventions: DRUG: KL1333 25 mg|DRUG: KL1333 50 mg|DRUG: KL1333 100 mg|DRUG: KL1333 200 mg|DRUG: KL1333 400 mg|DRUG: KL1333 600 mg|DRUG: KL1333 800 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation
Status: TERMINATED
Conditions: Anesthesia Intubation Complication|Premature Birth of Newborn|Other Preterm Infants|Propofol Overdose
Interventions: DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postprandial Inflammation in Rheumatoid Arthritis
Status: COMPLETED
Conditions: Arthritis, Rheumatoid|Inflammatory Response|Dietary Exposure|Diet, Healthy
Interventions: OTHER: Meal based on red meat, fish products or vegan products|OTHER: Meal based on red meat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tarlox and Sotorasib in Patients With KRAS G12C Mutations
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Sotorasib and Tarloxotinib|DRUG: Sotorasib and Tarloxotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACTyourCHANGE Study Protocol. Promoting Healthy Lifestyle With ACT for Obesity
Status: RECRUITING
Conditions: Health Behavior
Interventions: BEHAVIORAL: FACT Module Engagement|BEHAVIORAL: FACT Module Openness|BEHAVIORAL: FACT Module Awareness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ephedrine and Phenylephrine for Spinal Hypotension
Status: COMPLETED
Conditions: Spinal Hypotension
Interventions: DRUG: Phenylephrine|DRUG: Ephedrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Investigation in Corneal Sensation
Status: COMPLETED
Conditions: Cornea; Sense Loss
Interventions: DEVICE: Liquid Jet Esthesiometer Prototype|DEVICE: Tactile Esthesiometer Prototype|DEVICE: Cochet Bonnet esthesiometer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Multicenter, Double-blind, Parallel, Non-inferiority, Phase III Study
Status: UNKNOWN
Conditions: Influenza
Interventions: BIOLOGICAL: GC3106(quadrivalent cell-culture based influenza vaccine)|BIOLOGICAL: Fluarix™tetra Syringe Inj.(quadrivalent influenza vaccine)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Short- Term Follow up Of Neonates Born With Neural Tube Defect
Status: UNKNOWN
Conditions: Neural Tube Defects|Newborn Morbidity
Interventions: OTHER: In this study, the short-term follow-up of patients with neural tube defects in the neonatal intensive care unit will be evaluated retrospectively.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus)
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DRUG: sildenafil (Viagra)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Pharmacokinetics of GSK3923868 Inhalation Powder in Healthy Participants and Stable Asthmatics
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: GSK3923868|DRUG: Matching placebo|DEVICE: Monodose RS01
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Design and Evaluation of an In-Vehicle Real-Time Drunk Driving Detection System
Status: COMPLETED
Conditions: Drunk Driving|Alcohol Drinking|Impaired Driving
Interventions: OTHER: Driving under the influence of alcohol|OTHER: Driving under the influence of a placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase III Study in Refractory Behcet's Disease
Status: COMPLETED
Conditions: Behcet Disease
Interventions: DRUG: AIN457|DRUG: AIN457|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of INJEX Versus Traditional Syringe During Restoration of Primary Teeth
Status: COMPLETED
Conditions: Child Behavior
Interventions: DEVICE: INJEX [ Needle less anesthesia]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: BEHAVIORAL: Rehabilitation|PROCEDURE: Noninvasive brain stimulation: tDCS|PROCEDURE: Sham tDCS: placebo noninvasive brain stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diabetes Mellitus Type 2 Basal Insulin Dosing Requirements Study
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DEVICE: CGMS with an insulin pump using rapid acting insulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selecting Chemotherapy With High-throughput Drug Screen Assay Using Patient Derived Organoids in Patients With Refractory Solid Tumours (SCORE)
Status: UNKNOWN
Conditions: Organoids|HNSCC|Epithelial Ovarian Cancer|Colorectal Cancer
Interventions: PROCEDURE: Tumor Core Biopsy|PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Transvaginal Ultrasound-guided Aspiration for Treatment of Tubo-ovarian Abscess Compared With Laparoscopy
Status: ACTIVE_NOT_RECRUITING
Conditions: Uncomplicated Tubo Ovarian Abscess
Interventions: PROCEDURE: Ultrasound-guided transvaginal drainage|PROCEDURE: Laparoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial Investigating Lu AF28996 in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Lu AF28996|DRUG: Acetylsalicylic Acid|DRUG: Mefenamic Acid|DRUG: Amoxicillin/clavulanic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ingestion of Beta-alanine Effects in Well-trained Tennis Players
Status: COMPLETED
Conditions: Beta-alanine|Placebo
Interventions: DIETARY_SUPPLEMENT: Beta-alanine supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study of MK-2870 Alone or With Chemotherapy to Treat Gastrointestinal Cancers (MK-9999-02A)
Status: RECRUITING
Conditions: Colorectal Cancer|Pancreatic Ductal Adenocarcinoma|Biliary Tract Cancer
Interventions: BIOLOGICAL: Sacituzumab tirumotecan|DRUG: Fluorouracil (5-FU)|DRUG: Leucovorin (LV) or levoleucovorin|DRUG: Rescue medication|DRUG: Supportive care measures
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Firearm Storage Device Distribution to Families of Children With Mental Health Complaints
Status: COMPLETED
Conditions: Mental Health Disorders|Suicide or Selfinflicted Injury by Firearms and Explosives
Interventions: BEHAVIORAL: Free safe firearm storage device distribution|BEHAVIORAL: Low cost safe firearm storage device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Electrostimulation of Skeletal Muscles in Patients Listed for a Heart Transplant
Status: UNKNOWN
Conditions: Sarcopenia|Heart Failure, Systolic
Interventions: DEVICE: Neuromuscular electrical stimulation (NMES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pegylated Alfa-2b Interferon Therapy of Patients With Hepatitis C-related Cirrhosis and High Liver Cell Proliferation (P02733/MK-4031-085)
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular
Interventions: BIOLOGICAL: Peginterferon alfa-2b|OTHER: Observation (no treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Safety, and Efficacy of Brigatinib Monotherapy in Pediatric and Young Adult Participants With ALK+ Anaplastic Large Cell Lymphoma, Inflammatory Myofibroblastic Tumors or Other Solid Tumors
Status: WITHDRAWN
Conditions: Anaplastic Lymphoma Kinase Positive (ALK +) Anaplastic Large Cell Lymphoma|Inflammatory Myofibroblastic Tumors|Solid Tumors
Interventions: DRUG: Brigatinib|DRUG: Brigatinib AAF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ExtrAperitoneaL Plasty vs Intraperitoneal oNlay mEsh in Ventral Hernia Repair
Status: NOT_YET_RECRUITING
Conditions: Ventral Hernia|Abdominal Wall Defect
Interventions: PROCEDURE: Extended totally extraperitoneal repair|PROCEDURE: Intraperitoneal onlay mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis
Status: COMPLETED
Conditions: Non-infectious Anterior Uveitis
Interventions: DRUG: NS2|DRUG: Prednisolone acetate ophthalmic suspension (1%)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Long-Term Safety and Tolerability of Mesalamine Pellets in Participants With Ulcerative Colitis in Remission
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Encapsulated Mesalamine Granules (eMG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electromyography-biofeedback on the Motor Activation of the Extension of the Hand
Status: COMPLETED
Conditions: Stroke, Complication
Interventions: DEVICE: surface electromyography-biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of HBV Vaccine in Consolidation of Nucleos(t)Ide Analogues Therapy
Status: COMPLETED
Conditions: Chronic Hepatitis B
Interventions: DRUG: Engerix-B|DRUG: Tenofovir|DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT