pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)
Status: TERMINATED
Conditions: Amyotrophic Lateral Sclerosis (ALS)
Interventions: OTHER: Sleep study-guided adjustment of NIV|OTHER: Standard initiation of NIV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ascending Multi-dose Study of REGN727(SAR236553) With and Without Concomitant Atorvastatin
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: REGN727(SAR236553)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1B- Open Label Dose-Ranging Study of Oral AFX-2 in Adults With Chronic Lymphocytic Leukemia
Status: WITHDRAWN
Conditions: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: DRUG: AFX-2|DRUG: AFX-2|DRUG: AFX-2|DRUG: AFX-2|DRUG: AFX-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Spinal Anesthesia for Outpatient Abdominal Wall Surgery: Comparison of Bupivacaine, 2-chloroprocaine and Prilocaine
Status: COMPLETED
Conditions: Anesthesia, Spinal|Ambulatory Surgical Procedures|Hernia, Inguinal|Hernia, Umbilical
Interventions: DRUG: Bupivacaine|DRUG: Prilocaine|DRUG: Chloroprocaine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Drug Interaction Study of the Effects of PPI-668 on the Pharmacokinetics of Midazolam and Omeprazole
Status: COMPLETED
Conditions: Pharmacokinetic Assessments in Healthy Volunteers
Interventions: DRUG: PPI-668|DRUG: Midazolam|DRUG: Omeprazole|DRUG: Telaprevir
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Bisphosphonate and Anti-Angiogenesis Therapy With Pamidronate and Thalidomide
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pamidronate|DRUG: Thalidomide|DRUG: Zometa
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Rehabilitation Therapy for Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: Motivationally Enhanced Compensatory Cognitive Training|BEHAVIORAL: Goal-focused Supportive Contact
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Olanzapine for the Treatment of Nausea and Vomiting in Palliative Cancer Care
Status: UNKNOWN
Conditions: Nausea|Vomiting|End Stage Cancer
Interventions: DRUG: Olanzapine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study Comparing SB8 and Avastin® in Patients With Advanced Non-squamous Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer|Non-small Cell Lung Cancer
Interventions: DRUG: Bevacizumab|DRUG: SB8|DRUG: Carboplatin|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunosafe-CeD: Are Partially Hydrolysed Gluten Hamrful to Celiac Disease Patients?
Status: RECRUITING
Conditions: Celiac Disease|Food Intolerance
Interventions: DIETARY_SUPPLEMENT: Wheat gluten 1000 mg|DIETARY_SUPPLEMENT: Barley gluten 1000 mg|DIETARY_SUPPLEMENT: Barley gluten 50 mg|DIETARY_SUPPLEMENT: Barley hydrolyzed gluten 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Investigation of the Bi Flex M Multifocal IOL
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: Bi flex M multifocal intraocular lens|DEVICE: Bi flex 1.8 monofocal intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Quantification of the Visual Benefits of Soft Toric Contact Lenses Compared to Soft Spherical Contact Lenses
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Soft Toric Custom Made Contact lens|DEVICE: Soft Spherical Contact Lenses|DEVICE: Spectacle Correction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Transarterial Chemoembolization in Combination With Nivolumab Performed for Intermediate Stage Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Hepatic Carcinoma|Hepatocellular Cancer
Interventions: DRUG: Nivolumab|DRUG: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Highly Purified hMG With Recombinant FSH + Recombinant LH in Women Undergoing Intrauterine Insemination.
Status: COMPLETED
Conditions: Ovarian Stimulation Preceding Intrauterine Insemination
Interventions: DRUG: Menopur®, Ferring|DRUG: rFSH (Gonal®,
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients
Status: COMPLETED
Conditions: Moderate to Advanced Chronic Periodontitis
Interventions: DRUG: locally-applied minocycline HCl (1 mg)|PROCEDURE: scaling and root planing (Sc/RP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm
Status: COMPLETED
Conditions: Blepharospasm|Hemifacial Spasm|Botulinum Toxins, Type A
Interventions: DRUG: Botulinum Toxin Type A 100Unit/Vial (Product)|DRUG: Saline Solution for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracic Fluid Content by Electrical Cardiometry Versus Lung Ultrasound in Mechanically Ventilated Patients
Status: COMPLETED
Conditions: Thoracic Fluid Content|Electrical Cardiometry|Lung Ultrasound|Mechanical Ventilation|Intensive Care Unit
Interventions: DIAGNOSTIC_TEST: Thoracic fluid content by electrical cardiometry group|DIAGNOSTIC_TEST: Ultrasound examination group
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of Abatacept (BMS-188667) in Subjects With Active Rheumatoid Arthritis on Background Non-biologic DMARDS (Disease Modifying Antirheumatic Drugs) Who Have an Inadequate Response to Anti-TNF Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Abatacept|DRUG: Non-biologic Disease Modifying Anti-Rheumatic Drug (DMARD)|DRUG: Anti-Tumor Necrosing Factor (TNF) Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fingerprick Autologous Blood (FAB) in Mebomian Gland Dysfunction (MGD)
Status: UNKNOWN
Conditions: Meibomian Gland Dysfunction|Dry Eye Disease
Interventions: OTHER: Fingerprick autologous blood (FAB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Transfer Clinical Trial for Mucopolysaccharidosis (MPS) IIIB
Status: TERMINATED
Conditions: Mucopolysaccharidosis Type 3 B
Interventions: BIOLOGICAL: rAAV9.CMV.hNAGLU
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Management of Groin Flaps for Vascular Coverage
Status: COMPLETED
Conditions: Functional Status After Sartorius Flap of the Groin|Wound Complication
Interventions: OTHER: Early ambulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Diagnostic HER2DX-guided Treatment for patIents wIth Early-stage HER2-positive Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: HER2-positive Breast Cancer|Early-stage Breast Cancer
Interventions: DEVICE: Personalized treatment according to molecular diagnosis with HER2DX|OTHER: Treatment by physician´s choice, blinded to the diagnostic HER2DX test results
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Effects of Estrogen Replacement Therapy in Postmenopausal Women With Hypercalciuria and Low Bone Mass
Status: TERMINATED
Conditions: Hypercalciuria|Hypercalciuria, Familial Idiopathic|Osteopenia|Osteoporosis
Interventions: DRUG: Transdermal estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Targeted Interventions for Weight-Concerned Smokers
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: Naltrexone|DRUG: Transdermal nicotine replacement|BEHAVIORAL: Behavioral counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of the Combination of Azidothymidine and Interleukin-2 (IL-2) in the Treatment of HIV-Infected Patients
Status: COMPLETED
Conditions: HIV Infection
Interventions: DRUG: Zidovudine (AZT) & Interleukin-2 (IL2)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: GRASPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Status: WITHDRAWN
Conditions: Myocardial Stunning
Interventions: DRUG: IV Diazoxide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Status: COMPLETED
Conditions: Phantom Limb Pain
Interventions: DRUG: Perineural infusion [continuous peripheral nerve block(s)]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Blood Pressure After PREeclampsia/HELLP by SELF Monitoring Study
Status: COMPLETED
Conditions: Preeclampsia|Cardiovascular Risk Factor|Cardiovascular Diseases|Hypertension
Interventions: DEVICE: Home Blood Pressure Monitoring (HBPM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Postoperative Nausea and Vomiting
Interventions: DRUG: Levobupivacaine|DRUG: NaCl 0.9%|DRUG: Sevoflurane|DRUG: Propofol|DRUG: Sufentanil|DRUG: Atracurium|DRUG: Paracetamol|DRUG: Tramadol|DRUG: Piritramide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dyadic Creative Arts Therapies-based Intervention for Children With Intellectual and Developmental Disabilities
Status: RECRUITING
Conditions: Intellectual Disabilities Global Developmental Delay
Interventions: BEHAVIORAL: Dyadic CAT-based Intervention|BEHAVIORAL: Psycho-Educational Parent Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of XC221 in Patients With Mild COVID-19
Status: COMPLETED
Conditions: Sars-CoV-2 Infection
Interventions: DRUG: XC221|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Antipsychotic Discontinuation in Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer Disease|Psychotic Disorders|Agitation|Aggression
Interventions: DRUG: risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Osteochondritis Dissecans|Osteoarthritis|Cartilage Injury|Osteonecrosis
Interventions: PROCEDURE: Treatment of cartilage defects in the knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock
Status: COMPLETED
Conditions: Severe Sepsis|Septic Shock
Interventions: DRUG: Pioglitazone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sildenafil to Increase Exercise Capacity in Individuals With Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension
Status: COMPLETED
Conditions: Pulmonary Fibrosis|Hypertension, Pulmonary
Interventions: DRUG: Sildenafil (50 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Treatment Of Shallow Periodontal Pockets 4-6mm Using AIRFLOW Prophylaxis Master Device With Erythritol vs Manual Scalers
Status: RECRUITING
Conditions: Periodontal Pocket|Periodontitis|Gingival Diseases|Gingival Bleeding
Interventions: DEVICE: Electro Medical Systems AIRFLOW® Prophylaxis Master Device|OTHER: Hand and ultrasonic scalers and curettes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IMP4297 in Combination With Temozolomide in Patients With Advanced Solid Tumors and Small Cell Lung Cancer
Status: RECRUITING
Conditions: Advanced Solid Tumours|Small Cell Lung Cancer
Interventions: DRUG: IMP4297(senaparib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Sildenafil on Exercise Function and Capacity in Patients With Fontan Circulation
Status: COMPLETED
Conditions: Fontan Circulation
Interventions: DRUG: Sildenafil|DRUG: Placebo|DRUG: Sildenafil 2|DRUG: Placebo 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PPIO-004 Clinical Application of Efficacy Prediction Model Based on Epigenomics Sequencing Technology in Neoadjuvant Immunotherapy for Esophageal Cancer
Status: ENROLLING_BY_INVITATION
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Tislelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Ritonavir Versus NORVIR in Healthy Chinese Subjects
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Ritonavir for cycle1 and NORVIR for cycle 2|DRUG: NORVIR for cycle 1 and Ritonavir for cycle 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of First Line Vorinostat With Pemetrexed-cisplatin, in Patients With Malignant Pleural Mesothelioma
Status: WITHDRAWN
Conditions: Malignant Pleural Mesothelioma
Interventions: DRUG: Cisplatin|DRUG: Pemetrexed|DRUG: Vorinostat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacodynamic Influences of Candesartan, Atenolol, Hydrochlorothiazide and Drug Combinations in Hypertensive Patients.
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Candesartan Thiazide|DRUG: Atenolol Thiazide|DRUG: Thiazide Candesartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Pharmacokinetic Study to Evaluate the Dose-Proportionality of Tramadol (ULTRAM) Extended-Release (ER) in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Tramodol Extended-Release (ER)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Single Port and Two Ports Robotic Assisted Thoracic Surgery for Thymectomy
Status: RECRUITING
Conditions: Thymoma|Myasthenia Gravis Associated With Thymoma|Thymectomy
Interventions: PROCEDURE: Sigle port RATS|PROCEDURE: Two ports RATS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tele-Clinic Visits in Pediatric Marfan Patients Using Parental Echo: The Future?
Status: COMPLETED
Conditions: Marfan Syndrome
Interventions: OTHER: Tele-Clinic Visits Using Parent-Acquired Echos
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety And Efficacy Study Of Bosutinib In Patients With Philadelphia Chromosome Positive Chronic Myeloid Leukemia Previously Treated With One Or More Tyrosine Kinase Inhibitors
Status: TERMINATED
Conditions: Previously Treated PH + CML
Interventions: DRUG: Bosutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Oral Vinorelbine and Erlotinib in Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: Vinorelbine (Navelbine)|DRUG: Vinorelbine (Navelbine)|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Equol Supplementation on Blood Pressure and Vascular Function
Status: UNKNOWN
Conditions: Hypertension
Interventions: DIETARY_SUPPLEMENT: High equol group|DIETARY_SUPPLEMENT: Low equol group|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Role of Optic Nerve Sheath Fenestration in Leukemic Patients Having Increased Intracranial Pressure
Status: UNKNOWN
Conditions: Leukemic Patients With Increased Intracranial Pressure|Optic Nerve Sheath Fenestration
Interventions: PROCEDURE: optic nerve sheath fenestration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Mulligan Mobilization and Corticosteroid Injection in Rotator Cuff Lesions
Status: COMPLETED
Conditions: Rotator Cuff Tears
Interventions: OTHER: Corticosteroid Group|OTHER: Mulligan Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Online Prevention Program for Eating Disorders Applied to College Students. Spanish Validation of the eBodyProject
Status: RECRUITING
Conditions: Eating Disorders
Interventions: BEHAVIORAL: Spanish version eBodyProject|BEHAVIORAL: Psychoeducationa Prevention Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Comparison of Methylphenidate and Cognitive Behavioural Therapy for the Treatment of Binge Eating Disorder
Status: COMPLETED
Conditions: Binge-Eating Disorder
Interventions: DRUG: Methylphenidate|BEHAVIORAL: Cognitive Behavioral Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Dociparstat Sodium (ODSH) in Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Dociparstat sodium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lung Diseases, Interstitial
Interventions: DRUG: BI 1015550|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DPI 386 Nasal Gel for the Prevention of Nausea Associated With Motion Sickness
Status: TERMINATED
Conditions: Motion Sickness
Interventions: DRUG: DPI-386 Nasal Gel|DRUG: DPI-386 Placebo Nasal Gel|DRUG: Transderm Scop®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: LIquid Biopsy to prEdict Responses To First-line immunotherapY in Metastatic Non-small Cell LUNG Cancer. LIBERTY LUNG
Status: RECRUITING
Conditions: Metastatic Lung Cancer
Interventions: BIOLOGICAL: assessment of the predictive value of ctDNA level of the prominent mutant allele variation between baseline and week 6, on response to treatment according to RECIST 1.1 criteria.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?
Status: UNKNOWN
Conditions: Endocrine Disease|Fertility Decreased Male|DNA Damage
Interventions: DRUG: L-Carnitine and N-acetyl cysteine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chronic Coronary Syndrome in Swedish Primary Care
Status: RECRUITING
Conditions: Coronary Artery Disease
Interventions: DIAGNOSTIC_TEST: Package investigation|DEVICE: Sound registration with Cadscore® and added risk calculation|DIAGNOSTIC_TEST: Standard investigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Bioequivalence of a FDC Tablet of Linagliptin/Metformin (5mg/1000mg) Extended Release in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Linagliptin/Metformin ER FDC|DRUG: Linagliptin|DRUG: Metformin ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Geriatric Evaluation and Management With Survivorship Health Education (GEMS) for Older Survivors of Cancer
Status: RECRUITING
Conditions: Malignant Solid Neoplasm
Interventions: OTHER: Best Practice|OTHER: Comprehensive Geriatric Assessment|OTHER: Educational Intervention|OTHER: Exercise Intervention|OTHER: Questionnaire Administration|PROCEDURE: Tailored Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Aquatic Physical Therapy for Knee Osteoarthritis Patients
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Patient Education|OTHER: Aquatic Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores
Status: COMPLETED
Conditions: Herpes Labialis
Interventions: DRUG: ZEP-3 ointment 1.0%|DRUG: Acyclovir cream 5%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Comparison of Two Color Contact Lenses in Habitual Clear Contact Lens Wearers
Status: COMPLETED
Conditions: Myopia|Refractive Error
Interventions: DEVICE: Lotrafilcon B contact lens with color|DEVICE: Phemfilcon A contact lens with color
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Rotational Thromboelastometry [ROTEM] vs Thromboelastography [TEG] Guided Blood Component Use in Patients With Cirrhosis of Liver With Non-variceal Bleeding.
Status: RECRUITING
Conditions: Liver Cirrhosis
Interventions: DIAGNOSTIC_TEST: ROTEM|DIAGNOSTIC_TEST: Thromboelastography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Enasidenib (CC-90007) in Participants With Mild, Moderate and Severe Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis
Status: COMPLETED
Conditions: Hepatitis, Alcoholic
Interventions: DRUG: IMM 124-E (Hyperimmune Bovine Colostrum)|DRUG: Placebo (High protein milk powder)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Performance of Two Soft Toric Contact Lenses
Status: COMPLETED
Conditions: Astigmatism
Interventions: DEVICE: Lens 1 (omafilcon B)|DEVICE: Lens 2 (fanfilcon A)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Seeing-Moving-Playing: Early Rehabilitation Utilizing Visual and Vestibular Technology Following Traumatic Brain Injury
Status: UNKNOWN
Conditions: Mild Traumatic Brain Injury; Concussion
Interventions: OTHER: Vestibular-Visual Intervention|BEHAVIORAL: standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: FOS Immunohistochemical Staining of Colorectal Cancer and Its Adjacent Tissues
Status: RECRUITING
Conditions: Colorectal Cancer|Monkey Pox
Interventions: DIAGNOSTIC_TEST: Immunohistochemical staining with anti-FOS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Consolidative Radiotherapy Plus Maintenance Chemotherapy for Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer|Radiotherapy
Interventions: DRUG: maintenance chemotherapy|RADIATION: Consolidative Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PCSK 9 Inhibitor Added to High-Intensity Statin Therapy to Prevent Cardiovascular Events in Patients With ACS After PCI
Status: RECRUITING
Conditions: Acute Coronary Syndrome|Hyperlipidemias|Percutaneous Coronary Intervention|Cardiovascular Events
Interventions: DRUG: Placebo plus high-intensity statin|DRUG: PCSK 9 Inhibitor plus high-intensity statin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis
Status: RECRUITING
Conditions: Antineutrophil Cytoplasmic Antibody-associated Vasculitis
Interventions: DRUG: Avacopan|DRUG: Placebo|DRUG: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of REGN3767 (Anti-LAG-3) With or Without REGN2810 (Anti-PD1) in Advanced Cancers
Status: COMPLETED
Conditions: Malignancies
Interventions: DRUG: REGN3767|DRUG: cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perineal Massage for Pessary Examinations
Status: RECRUITING
Conditions: Prolapse, Vaginal|Stress Urinary Incontinence|Pessaries|Pain
Interventions: OTHER: Perineal massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PembROlizuMab Immunotherapy Versus Standard Chemotherapy for Advanced prE-treated Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Pleural Mesothelioma Malignant Advanced
Interventions: DRUG: Pembrolizumab|DRUG: Gemcitabine|DRUG: Vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetics of Torasemide and Spironolactone in Hypertension Treatment
Status: COMPLETED
Conditions: Hypertension|Genetic Predisposition|Drug Effect
Interventions: DRUG: Torasemide|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Toripalimab in Combined With Cetuximab，Chemotherapy for Conversion Therapy of Locally Nonresectable OCSCC
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of Head and Neck
Interventions: DRUG: Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-acetylcysteine Reduces Acetaldehyde Levels in Binge Alcohol Drinking
Status: COMPLETED
Conditions: Ethanol Intoxication
Interventions: DRUG: N Acetylcysteine|OTHER: Lemon juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of HGP0412 and HIP1402 in Patients With BPH
Status: COMPLETED
Conditions: Benign Prostate Hyperplasia
Interventions: DRUG: Placebo|DRUG: HGP0412 capsule|DRUG: HIP1402 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Mechanisms of Insulin Facilitation of Memory
Status: COMPLETED
Conditions: Memory Disorders
Interventions: DRUG: Insulin|OTHER: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Safety and Tolerability of a Nasal Spray to Treat Perennial Allergic Rhinitis
Status: COMPLETED
Conditions: Perennial Allergic Rhinitis
Interventions: DRUG: 0.15% azelastine hydrochloride|DRUG: Mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunoadsorption vs. Plasmapheresis in the Escalation Therapy of Relapse in Multiple Sclerosis
Status: COMPLETED
Conditions: Multiple Sclerosis|Clinically Isolated Syndrome
Interventions: PROCEDURE: Immunoadsorption|PROCEDURE: Plasmapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravitreal Infliximab for Diabetic Macular Edema (DME) and Choroidal Neovascularization (CNV)
Status: UNKNOWN
Conditions: Diabetic Retinopathy|Macular Degeneration
Interventions: DRUG: intravitreal injection of infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biodistribution and Pharmacokinetic Study of 18F-DCFBC Prostate Specific Membrane Antigen Based PET in Patients With Advanced Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: 18F-DCFBC
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Peer Support Experience for Patients Discharged From Acute Psychiatric Care
Status: COMPLETED
Conditions: Depression|Bipolar Disorder|Schizophrenia
Interventions: BEHAVIORAL: Supportive/reminder text messaging plus peer support|BEHAVIORAL: Supportive/reminder text messaging|BEHAVIORAL: Peer support only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Prostaglandin Analogue Washout Following Long-term Therapy in Adults With Primary Open Angle Glaucoma
Status: COMPLETED
Conditions: Primary Open-Angle Glaucoma, Mild Stage|Glaucoma, Suspect|Ocular Hypertension
Interventions: OTHER: Discontinuation of topical prostaglandin analogue therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmakokinetik of Caffeine in Epiretinal Membranes After Oral Intake: a Pilot Study
Status: COMPLETED
Conditions: Epiretinal Membrane
Interventions: PROCEDURE: vitrectomy with membrane peeling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Mirabegron, Propevirine, Solifenacin for Treatment of Lower Urinary Tract Symptoms During Intravesical BCG Instillation
Status: UNKNOWN
Conditions: Voiding Disorders
Interventions: DRUG: Mirabegron, Propevirine, Solifenacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of AMPS on Cardiovascular, Functional Capacity and Postural Control in Patients With Parkinson's Disease
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: DEVICE: Automated mechanical peripheral stimulation|DEVICE: SHAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Tolerability and Pharmacokinetics of JNJ-54861911 in Healthy Volunteers Compared With Placebo
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: JNJ-54861911 1mg|DRUG: JNJ-54861911 3 mg|DRUG: JNJ-54861911 9 mg|DRUG: JNJ-54861911 27 mg|DRUG: JNJ-54861911 81 mg|DRUG: JNJ-54861911 160 mg|DRUG: JNJ-54861911 tbd|DRUG: JNJ-54861911 9 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Correlation of Metabolic Imaging With Immune Markers in NSCLC Candidate to Immunotherapy.
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung|Positron-Emission Tomography|Immunotherapy
Interventions: DIAGNOSTIC_TEST: PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Purged Circulating Tumor Cells (CTCs) From Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Metastatic Breast Carcinoma|Invasive Breast Carcinoma
Interventions: DRUG: Carboplatin|DRUG: Cyclophosphamide|DRUG: Thiotepa|PROCEDURE: Stem Cell Transplant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Two Methodologies for Measuring Blood Flow in the Brain in Response to Non-Drug Stimuli (P08085/MK-0000-180)
Status: COMPLETED
Conditions: Functional Magnetic Resonance Imaging
Interventions: PROCEDURE: fMRI with sensory stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: A Phase IIclinical Trial of Carboplatin and Paclitaxel or Carboplatin and Gemcitabine in Platinum-sensitive, Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
Status: UNKNOWN
Conditions: Fallopian Tube Cancer|Ovarian Cancer|Primary Peritoneal Cancer
Interventions: DRUG: carboplatin and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Erythropoietin Gel as an Adjunct to Split-Thickness Apically Positioned Flap in Augmentation of Attached Gingiva
Status: RECRUITING
Conditions: Erythropoietin|Recession
Interventions: DRUG: Split thickness Apically positioned flap with Chitosan based Erythropoietin Gel application|DRUG: Split thickness Apically positioned flap without Erythropoietin application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain
Status: ACTIVE_NOT_RECRUITING
Conditions: Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Interventions: DRUG: Psilocybin|BEHAVIORAL: Psychotherapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effectiveness of Supervised Training Program on Mobility and Balance Confidence in Individual With Lower Limb Amputation
Status: COMPLETED
Conditions: Amputation
Interventions: OTHER: Gait Training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1/2a Dose Escalation Study in Participants With CLL, SLL, or NHL
Status: COMPLETED
Conditions: Follicular Lymphoma (FL/Indolent NHL)|Aggressive NHL (a NHL)|Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL)|T-cell Lymphoma (PTCL and CTCL)|B-cell Non Hodgkin Lymphoma (NHL)
Interventions: DRUG: Cerdulatinib|BIOLOGICAL: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Cholesterol Level on Long-term Coronary Bypass Graft Patency
Status: WITHDRAWN
Conditions: Coronary Artery Disease|Bypass Graft Stenosis|Dyslipidemias|Bypass Graft Occlusion|Coronary Bypass Graft Stenosis|Coronary Artery Stenosis|Hyperlipidemia|Hypercholesterolemia
Interventions: RADIATION: Computed tomography coronary angiogram
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The TANTALUS® II System for the Treatment of Type 2 Diabetes: A Randomized Study
Status: TERMINATED
Conditions: Type 2 Diabetes Mellitus|Overweight
Interventions: DEVICE: TANTALUS(TM) System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Neuromuscular Relaxation Optimizing Low-Pressure Bariatric Surgery
Status: UNKNOWN
Conditions: Bariatric Surgery
Interventions: PROCEDURE: Deep Neuromuscular Blockade|DRUG: Sugammadex
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Enzalutamide and Hormone Therapy Before, During, and After Radiation for High Risk Localized Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Leuprolide acetate|RADIATION: radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Implants Placed Without Bone Grafts in Two Different Sinus Floor Elevation Techniques.
Status: COMPLETED
Conditions: Dental Implant Placement
Interventions: PROCEDURE: crestal sinus approach technique|PROCEDURE: Lateral sinus approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Multicenter Trial to Determine the Efficacy and Outcome of the UCRI Biomarker Panel and Algorithm to Detect Mucosal Healing in Moderate to Severe Ulcerative Colitis Patients.
Status: RECRUITING
Conditions: Ulcerative Colitis
Interventions: DIAGNOSTIC_TEST: UCRI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neoadjuvant Fluzoparib in Germline BRCA-mutated Three-negative Breast Cancer Breast Cancer
Status: RECRUITING
Conditions: TNBC - Triple-Negative Breast Cancer
Interventions: DRUG: Fluzoparib+Paclitaxel|DRUG: Epirubicin+Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Gastrointestinal Tolerance of Various Infant Formulas in Healthy Term Infants
Status: COMPLETED
Conditions: Infant, Newborn
Interventions: OTHER: soy protein formula|OTHER: Commercially available soy formula|OTHER: Soy formula experimental #2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myocardial Work and Metabolism in CRT
Status: UNKNOWN
Conditions: Left Ventricular Dyssynchrony|Heart Failure|Left Bundle Branch Block|Cardiomyopathy
Interventions: DEVICE: Cardiac resynchronisation therapy|OTHER: Echocardiography|OTHER: Magnetic Resonance Imaging|OTHER: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose:
Clinical trial: Study of INCA32459 a LAG-3 and PD-1 Bispecific Antibody in Participants With Select Advanced Malignancies
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignancies
Interventions: DRUG: INCA32459-101
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Arm Crank Versus Treadmill Exercises on Heart Rate Variability in Adult Subjects.
Status: COMPLETED
Conditions: Heart Rate Variability
Interventions: DEVICE: Arm crank|DEVICE: Treadmill|OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of the LumiraDx Point of Care D-Dimer and CRP Tests
Status: ACTIVE_NOT_RECRUITING
Conditions: Embolism and Thrombosis|Infection|Inflammation
Interventions: DIAGNOSTIC_TEST: Venepuncture|DIAGNOSTIC_TEST: Fingerstick
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study Evaluating Venetoclax Alone and in Combination With Azacitidine in Participants With Relapsed/Refractory Myelodysplastic Syndromes (MDS)
Status: COMPLETED
Conditions: Myelodysplastic Syndromes (MDS)
Interventions: DRUG: venetoclax|DRUG: azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's Disease
Status: RECRUITING
Conditions: Behçet Disease
Interventions: DRUG: Apremilast|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prognostic Role of Primary Non Small Cell Lung Carcinoma Standardized F18-FDG Uptake Values (SUV and TLG) Measured With F18-fluorodeoxyglucose Positron Emission Tomography (F18-FDG-PET): a Non Interventional Study.
Status: UNKNOWN
Conditions: Non Small Cell Lung Carcinoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Between Ultrasound-guided Ilioinguinal, Iliohypogastric Nerve Blocks, TAP Block and Quadratus Lumborum Block in Patients Scheduled for Lower Segment Ceserian Sections.
Status: NOT_YET_RECRUITING
Conditions: Analgesia
Interventions: OTHER: General anesthesia|OTHER: Ilioinguinal, iliohypogastric nerve blocks|OTHER: TAP block|OTHER: Quadratus lumborum block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Adjuvant Aspirin Treatment for Colon Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Colon Cancer
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability and Preliminary Efficacy of ASP0367 (MA-0211) in Pediatric Male Participants With Duchenne Muscular Dystrophy (DMD)
Status: TERMINATED
Conditions: Duchenne Muscular Dystrophy (DMD)
Interventions: DRUG: Bocidelpar|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT