pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Dalpiciclib With Endocrine Therapy for Advanced Breast Cancer After CDK4/6 Inhibitor Failure (DAWNA-FES)
Status: RECRUITING
Conditions: Advanced Breast Cancer
Interventions: DRUG: The combination of Dalpiciclib with physician-selected endocrine therapy|DRUG: Chemotherapy selected by the physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Melatonin as an Adjunctive Therapy for Chronic Periodontitis.
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: DIETARY_SUPPLEMENT: Melatonin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Does Improving Vagal Tone Increase Mitochondrial Bioenergetics
Status: COMPLETED
Conditions: Functional Gastrointestinal Disorders|Irritable Bowel Syndrome|Dyspepsia|Functional Abdominal Pain Syndrome
Interventions: DEVICE: Percutaneous neurostimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacogenetics of Disulfiram for Cocaine
Status: COMPLETED
Conditions: Cocaine Dependence|Opioid Dependence
Interventions: DRUG: Disulfiram|DRUG: Methadone|BEHAVIORAL: CBT|OTHER: Lactose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Nebulization and Positive Expiratory Pressure Combination
Status: UNKNOWN
Conditions: Cystic Fibrosis|Healthy Subjects
Interventions: DEVICE: Positive expiratory pressure|DRUG: amikacine nebulization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodilution and Coagulopathy With 3 Colloids
Status: COMPLETED
Conditions: Dilutional Coagulopathy
Interventions: OTHER: Induced Coagulopathy by HES (Tetraspan), Gelatin (Physiogel), Gelatin balanced (Physiogel balanced)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidural Catheter and Surgically Implanted Rectus Sheath Catheter in Management of Postoperative Pain
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DEVICE: Epidural catheter|DEVICE: rectus sheath catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of the Effect of an Elastic Compression Medical Device, on Water Balance Change in Healthy Subjects
Status: COMPLETED
Conditions: Obstructive Sleep Apnea-hypopnea Syndrome (OSAHS)
Interventions: DEVICE: Elastic Compression Prototype
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)
Status: COMPLETED
Conditions: Renal Transplant|Renin-Angiotensin System|Rejection Acute Renal|Rejection Chronic Renal|Rejection of Renal Transplant
Interventions: PROCEDURE: Renal Transplantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: IQP-CL-101 in IBS Management
Status: COMPLETED
Conditions: Irritable Bowel Syndrome
Interventions: DIETARY_SUPPLEMENT: IQP-CL-101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Anterior Ligament Rupture With Internal Brace Repair - A Prospective Randomised Controlled Study.
Status: TERMINATED
Conditions: Ligament; Laxity, Knee|Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: Repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Combined Afib Ablation and RA Denervation for the Maintenance of Sinus Rhythm and Management of Resistant Hypertension
Status: WITHDRAWN
Conditions: Afib|Hypertension
Interventions: PROCEDURE: Renal Artery denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Irradiation and Tremelimumab in Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: RADIATION: Brain radiotherapy or Stereotactic Radiosurgery|DRUG: Tremelimumab|DRUG: HER2 directed therapy|DRUG: Durvalumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Changes in Power and Cylinder Axis of Toric Soft Contact Lenses (LKL)
Status: COMPLETED
Conditions: Visual Acuity Reduced Transiently
Interventions: OTHER: soft contact lens Toric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SCREENING
Clinical trial: Evaluation of Microbial Colonisation and Contamination Caused by the Transvaginal and Transabdominal Access for Cholecystectomy
Status: COMPLETED
Conditions: Cholecystectomy
Interventions: PROCEDURE: Smear test vaginally, intraabdominally|PROCEDURE: Smear test vaginally, intraabdominally
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: High Flow Nasal Cannula With Noninvasive Ventilation
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: OTHER: Standard of Care - Nasal Cannula|OTHER: High-flow nasal cannula|OTHER: HFNC plus non-invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MS-275 in Treating Patients With Hematologic Cancer
Status: COMPLETED
Conditions: Leukemia|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Diseases
Interventions: DRUG: entinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Fibrinogen in Haemorrhage of Delivery
Status: COMPLETED
Conditions: Post-Partum Hemorrhage
Interventions: DRUG: Human Fibrinogen concentrate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Isolated Pelvic and Limb Perfusion in the Treatment of Locally Advanced Sarcoma of Pelvis and Limbs' Girdle
Status: UNKNOWN
Conditions: Sarcoma of Pelvis
Interventions: DRUG: Tasonermine (TNFa)|DRUG: Melphalan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Rehabilitation Combined With a Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19
Status: RECRUITING
Conditions: Post-COVID-19 Syndrome
Interventions: PROCEDURE: Rehabilitation combined to a digital maintenance program|PROCEDURE: Rehabilitation without maintenance program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.
Status: COMPLETED
Conditions: Delayed Emergence From Anesthesia
Interventions: DRUG: Desflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SHR - 1209 Treatment Efficacy and Safety of the Patients With Hypercholesterolemia Ⅲ Period Clinical Research
Status: COMPLETED
Conditions: Primary Hypercholesterolemia
Interventions: DRUG: SHR-1209|DRUG: SHR-1209 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Text Message Safety Behavior Fading for Appearance Concerns
Status: COMPLETED
Conditions: Body Dysmorphic Disorders|Social Anxiety Disorder|Eating Disorders
Interventions: BEHAVIORAL: Safety Behavior Fading for Appearance Concerns|BEHAVIORAL: Unhealthy Behavior Fading
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pulsed Radiofrequency vs. Steroid Injections for Occipital Neuralgia
Status: COMPLETED
Conditions: Occipital Neuralgia
Interventions: PROCEDURE: Pulsed radiofrequency|DRUG: Corticosteroid injection|DRUG: Local anethestic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Therapy With Zoledronic Acid in Patients With Multiple Myeloma Stage I
Status: TERMINATED
Conditions: Multiple Myeloma Stage I
Interventions: DRUG: Zoledronic acid|DIETARY_SUPPLEMENT: Calcium / Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective PuraPly™ AM Case Series Study
Status: COMPLETED
Conditions: Pressure Ulcers|Venous Ulcers|Diabetic Ulcers|Surgical Wounds|Trauma Wounds
Interventions: DEVICE: PuraPly™ Antimicrobial Wound Matrix
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clofarabine, Cytarabine, and G-CSF in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Adult Acute Promyelocytic Leukemia (M3)|Recurrent Adult Acute Myeloid Leukemia
Interventions: DRUG: clofarabine|DRUG: cytarabine|BIOLOGICAL: filgrastim
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Block Versus Erector Spina Plane Block
Status: UNKNOWN
Conditions: Intraoperative Pain Control
Interventions: DEVICE: Ultrasound guided erector spinae block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Immuno-virological Evaluation of Persons Living With HIV (PLWH)
Status: NOT_YET_RECRUITING
Conditions: HIV-1-infection|HIV Seropositivity
Interventions: PROCEDURE: Leucapheresis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postural Management for Hip Luxation in Quadriplegic Cerebral Palsy
Status: ACTIVE_NOT_RECRUITING
Conditions: Quadriplegic Cerebral Palsy
Interventions: OTHER: postural management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Gene Transfer Clinical Trial for Duchenne Muscular Dystrophy Using rAAVrh74.MCK.GALGT2
Status: WITHDRAWN
Conditions: Duchenne Muscular Dystrophy
Interventions: BIOLOGICAL: rAAVrh74.MCK.GALGT2|OTHER: PLACEBO (Saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Laser Treatment to Improve Skin Quality
Status: NOT_YET_RECRUITING
Conditions: Skin Quality
Interventions: DEVICE: 1064NM pico Laser|DEVICE: 755NM pico Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rotation Technique for the Insertion of the ProSeal Laryngeal Mask Airway in Pediatric Patients
Status: COMPLETED
Conditions: Intubation
Interventions: DEVICE: Standard technique group|DEVICE: Rotation technique group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose:
Clinical trial: Assessment of the Effectiveness of Continuous Labour Support by a Trained Companion of Choice on Events of Labor and Maternal Satisfaction in the Bugisu Sub Region, Uganda
Status: UNKNOWN
Conditions: Labor Long
Interventions: BEHAVIORAL: Support from a trained companion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy Study of Liraglutide vs.Sitagliptin vs. Glargine on Liver Fat in T2DM Subjects
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Liraglutide combined with metformin|DRUG: Insulin glargine combined with metformin|DRUG: Sitagliptin combined with metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074
Status: COMPLETED
Conditions: Drug Interaction
Interventions: DRUG: BIIB074|DRUG: Valproic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Optimal Dosing of Piperacillin-tazobactam in Intensive Care Unit Patients: Extended Versus Continuous Infusion
Status: COMPLETED
Conditions: Infectious Disease
Interventions: DRUG: piperacillin continuous infusion|DRUG: piperacillin extended infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimally Invasive Treatment of Hypertensive Basal Ganglia Hemorrhage by Transfrontal Keyhole Neuroendoscopy
Status: UNKNOWN
Conditions: Basal Ganglia Hemorrhage
Interventions: PROCEDURE: Keyhole neuroendoscopic transfrontal ultrasound-guided hematoma removal|PROCEDURE: Small bone window craniotomy for hematoma removal under microscope
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Optimizing Quality of Life in Women Living With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)|BEHAVIORAL: Cognitive Behavioral Stress Management (CBSM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Head and Neck Cancer|Malignant Melanoma|Colorectal Cancer|Renal Cell Carcinoma|Cervical Cancer|Breast Cancer
Interventions: DRUG: GM103 (Part A)|DRUG: GM103 (Part B)|DRUG: GM103 and Pembrolizumab (Part C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study of a Novel Oncolytic Vaccinia Virus RGV004 in the Treatment of Refractory/Relapsed B-cell Lymphoma
Status: RECRUITING
Conditions: Relapsed or Refractory B-cell Lymphoma
Interventions: BIOLOGICAL: RGV004
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Umbilical Cord Blood Mononuclear Cell Gel in the Treatment of Refractory Diabetic Foot Ulcer
Status: RECRUITING
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: Umbilical cord blood mononuclear cell gel（MNC）|DRUG: The platelet rich plasma（PRP）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Complete Digital Workflows for the Treatment With Multiple-unit Implant-supported Fixed Dental Prostheses (iFDP)
Status: COMPLETED
Conditions: Partial-edentulism|Implant-supported Fixed Dental Prostheses (iFDP)
Interventions: PROCEDURE: Workflow A|PROCEDURE: Workflow B|PROCEDURE: Workflow C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa
Status: TERMINATED
Conditions: Loiasis
Interventions: DRUG: Imatinib Mesylate|DRUG: Imatinib Mesylate|DRUG: Imatinib Mesylate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of UCB Combined With UC-MSCs in the Treatment of Bone Marrow Failure Disorders
Status: RECRUITING
Conditions: Bone Marrow Failure Disorders
Interventions: DRUG: Cyclosporine A|BIOLOGICAL: Umbilical cord blood & Umbilical cord derived mesenchymal stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acid Administration in Dialysis Patients
Status: COMPLETED
Conditions: End Stage Renal Disease
Interventions: DIETARY_SUPPLEMENT: fish oil|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CAR-T Therapy in Relapsed or Refractory Haematopoietic and Lymphoid Malignancies
Status: UNKNOWN
Conditions: Leukemia|Lymphoma
Interventions: BIOLOGICAL: Autologous CAR-T
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of a Physical Exercise Intervention Based on the Transtheoretical Model on Blood Pressure
Status: ENROLLING_BY_INVITATION
Conditions: Hypertension
Interventions: BEHAVIORAL: Physical exercise intervention|BEHAVIORAL: Workshops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Antibiotics and Vaccine Immune Responses Study
Status: RECRUITING
Conditions: Vaccine Response Impaired
Interventions: BIOLOGICAL: BCG vaccine|BIOLOGICAL: Yellow Fever vaccine|DRUG: Vancomycin Oral Capsule|DRUG: Neomycin Oral Product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients
Status: COMPLETED
Conditions: End-stage Renal Disease
Interventions: DRUG: Pioglitazone|DRUG: placebo comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Use of Benralizumab in Patients With Chronic Spontaneous Urticaria Who Are Symptomatic Despite the Use of Antihistamines (ARROYO)
Status: TERMINATED
Conditions: Chronic Spontaneous Urticaria
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo and Benralizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Wayfinding Intervention and Long-Term Memory
Status: RECRUITING
Conditions: Long-Term Memory Decline|Mild Cognitive Impairment
Interventions: BEHAVIORAL: LabyrinthVR software|BEHAVIORAL: Placebo Games software|BEHAVIORAL: Labyrinth Tablet software|BEHAVIORAL: Labyrinth VR wireless
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Randomized, Double Blind, Placebo-Controlled, Multi-Center Phase III Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Testosterone and Sperm Concentration Following Treatment With 12.5 mg or 25 mg Androxal or AndroGel 1.62%
Status: COMPLETED
Conditions: Secondary Hypogonadism
Interventions: DRUG: Androxal 12.5 mg/25 mg|DRUG: Placebo Capsules|DRUG: AndroGel 1.62%|DRUG: Placebo Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravascular Imaging Study of the Effect of Inclisiran on Plaque in Patients With Acute Myocardial Infarction
Status: RECRUITING
Conditions: Plaque, Atherosclerotic
Interventions: DRUG: atorvastatin|PROCEDURE: IVUS/OCT|DRUG: inclisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Fluzone® Quadrivalent and Fluzone® High-Dose, Influenza Vaccines
Status: COMPLETED
Conditions: Influenza|Flu
Interventions: BIOLOGICAL: Fluzone Quadrivalent vaccine|BIOLOGICAL: Fluzone Quadrivalent vaccine|BIOLOGICAL: Fluzone High-Dose vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Descriptive Study of the Evolution in Proportion of Regulatory B Lymphocytes in Patients Hospitalized in Intensive Care for Severe Sepsis
Status: UNKNOWN
Conditions: Severe Sepsis
Interventions: OTHER: Describe for the first time the kinetics of evolution in proportion of the circulating Brég in patients with severe septic state, at times D0, D2, D7 and D14 of hospitalization in medical reanimation.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: HNO Donor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Influence of Oxytocin on Automatic Imitation Behaviour in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Oxytocin|DRUG: Sea water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Conducted in Healthy Male Subjects to Investigate the Safety and Tolerability of AC-76, Its Fate in the Body, and Its Effect on the Body
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: AC-076 for s.c. administration|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Linked Color Imaging vs White Light Imaging for Detection of Gastric Cancer Precursors
Status: COMPLETED
Conditions: Early Gastric Cancer|Barrett Esophagus
Interventions: DIAGNOSTIC_TEST: Linked Color Imaging|DIAGNOSTIC_TEST: White Light Imaging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Kinesio Taping With &Without Craniosacral Therapy in Pregnant Females With SIJ Dysfunction.
Status: COMPLETED
Conditions: Sacral Disorder
Interventions: OTHER: kinesiotaping without craniosacral therapy|OTHER: kinesiotaping with craniosacral therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MF-4181 for the Reduction of Scars Secondary to Abdominoplasty or Laparoscopy/Laparotomy Gynecologic Procedures
Status: COMPLETED
Conditions: Scars
Interventions: OTHER: MF-4181|OTHER: Standard surgical wound closure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Relapsing Multiple Sclerosis|Primary Progressive Multiple Sclerosis
Interventions: DRUG: Ocrelizumab IV|DRUG: Ocrelizumab SC|DRUG: Methylprednisolone IV|DRUG: Diphenhydramine IV|DRUG: Dexamethasone given orally|DRUG: Desloratadine given orally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rectal Dexmedetomidine Niosomes for Postoperative Analgesia in Pediatric Cancer Patients.
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: DRUG: DEX-IV|DRUG: DEX-Rectal|DRUG: DEX-Nano-Rectal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuropsyquiatric Evolution After Introduction of Raltegravir QD in Substitution of Dolutegravir: NEAR QD Study
Status: UNKNOWN
Conditions: HIV Infections
Interventions: DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment of Coronavirus COVID-19 Pneumonia (Pathogen SARS-CoV-2) With Cryopreserved Allogeneic P_MMSCs and UC-MMSCs
Status: UNKNOWN
Conditions: COVID-19 Pneumonia
Interventions: PROCEDURE: Placenta-Derived MMSCs; Cryopreserved Placenta-Derived Multipotent Mesenchymal Stromal Cells|DRUG: Antibiotics|DRUG: Hormones|DRUG: Anticoagulant Therapy|DEVICE: Оxygen therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients
Status: COMPLETED
Conditions: Supplementation|Bone Health|Crohn's Disease
Interventions: DIETARY_SUPPLEMENT: phylloquinone (vitamin K1)|DIETARY_SUPPLEMENT: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD
Status: RECRUITING
Conditions: Opioid Use Disorder|Serious Bacterial Infections
Interventions: BEHAVIORAL: Smart IOP Intervention|BEHAVIORAL: Peer Recovery Coach
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast Cancer
Status: RECRUITING
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Metastatic Malignant Neoplasm in the Leptomeninges
Interventions: OTHER: Digital Photography|PROCEDURE: Lumbar Puncture|PROCEDURE: Magnetic Resonance Imaging|DEVICE: Medical Device Usage and Evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FS2 Safety and Tolerability Study in Healthy Volunteers
Status: COMPLETED
Conditions: Cicatrix|Cicatrix, Hypertrophic|Keloid
Interventions: DRUG: Acute Application of kynurenic acid cream|DRUG: Chronic application of kynurenic acid cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MVA-BN-RSV Vaccine Trial
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Infections
Interventions: BIOLOGICAL: MVA-BN-RSV vaccine|BIOLOGICAL: Tris Buffered Saline (TBS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Fulvestrant and/or Trastuzumab as First-Line Therapy in Treating Postmenopausal Women With Stage IV Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Faslodex|BIOLOGICAL: Herceptin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Test the Effect of CDP870 in the Treatment of Crohn's Disease Over 26 Weeks, Comparing CDP870 to a Dummy Drug (Placebo), Following 3 Doses of Active Drug (CDP870).
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: Certolizumab Pegol (CDP870)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose:
Clinical trial: Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
Status: WITHDRAWN
Conditions: Acute Kidney Injury|Renal Insufficiency, Chronic|Contrast-induced Nephropathy|Liver Transplantation|Contrast Media
Interventions: DIAGNOSTIC_TEST: Intravenous administration of iodinated contrast medium for coronary CT angiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Assess Safety and Efficacy of the Second Mitochondrial-derived Activator of Caspases (SMAC) Mimetic Debio 1143
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Debio 1143|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Weaning of Immunosuppression in Nephritis of Lupus
Status: UNKNOWN
Conditions: Nephritis of Lupus
Interventions: DRUG: mycophenolate mofetil or azathioprine|OTHER: immunosuppressive treatment discontinuation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Moderate to Severe Bronchiolitis: Standard Therapy Versus Therapy With NaCl 3% Inhalations
Status: COMPLETED
Conditions: Moderate to Severe Bronchiolitis
Interventions: DRUG: NaCl 3%|OTHER: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Influence of Sweet Substrates on Hunger, Gastrointestinal Hormones and the Migrating Motor Complex
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 50g glucose|DIETARY_SUPPLEMENT: 25g fructose|DIETARY_SUPPLEMENT: 220mg acesulfame-K|DIETARY_SUPPLEMENT: 250mL tap water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of 3TC or FTC Mono-therapy Compared to Continuing HAART as a Bridging Strategy
Status: TERMINATED
Conditions: HIV Disease
Interventions: DRUG: HAART regimen|DRUG: 3TC or FTC monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced or Metastatic Breast Cancer
Interventions: DRUG: Trastuzumab deruxtecan|DRUG: Capecitabine|DRUG: Paclitaxel|DRUG: Nab-Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
Status: COMPLETED
Conditions: Postoperative Complications|Memory Disorders
Interventions: DEVICE: pulsatile saline lavage|DEVICE: carbon dioxide lavage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Rehabilitation of Airway Protection in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson Disease|Dysphagia
Interventions: BEHAVIORAL: Expiratory Muscle Strength Training + Cough Skill Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: MLN8237 in Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma Treated With Rituximab +/- Vincristine
Status: COMPLETED
Conditions: Diffuse Large B-Cell Lymphoma|Transformed Follicular Lymphoma|Mantle Cell Lymphoma|Burkitt's Lymphoma
Interventions: DRUG: Alisertib (MLN8237)|DRUG: Rituximab|DRUG: Vincristine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Lymphoid Leukemia|Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia|Relapsed Acute Lymphoblastic Leukemia
Interventions: DRUG: CPX-351
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Compare the Pharmacokinetics of NVP-1205 and Coadministration of Rosuvastatin and Ezetimibe
Status: COMPLETED
Conditions: Dyslipidemia
Interventions: DRUG: NVP-1205|DRUG: rosuvastatin and ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Community Support Network Intervention in SOAR Project Intimate Partner Violence-Related Traumatic Brain Injury
Status: RECRUITING
Conditions: Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: Community Support Network (CSN) intervention|BEHAVIORAL: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Hypertension, Pregnancy Induced|Hypertension Complicating Pregnancy|Preeclampsia|Cardiovascular Diseases|Patient Engagement
Interventions: OTHER: Decision aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Ground-Breaking Electroporation-based Intervention for PERSistent Atrial Fibrillation Treatment (BEAT PERS-AF)
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DEVICE: PVI and Linear lesion using PEF|DEVICE: PVI and Linear lesion using CFRF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of SANTYL® vs Hydrogel (SoloSite®) for Pressure Ulcers
Status: TERMINATED
Conditions: Pressure Ulcer
Interventions: BIOLOGICAL: Santyl|BIOLOGICAL: SoloSite®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasound Monitoring of Fetuses With Vascular Intra-uterine Growth Restriction (IUGR) Using the Isthmus Systolic Index (ISI): Feasibility, Comparison to Normal Fetuses and Association With Perinatal Mortality
Status: UNKNOWN
Conditions: IUGR
Interventions: OTHER: ISI index on Doppler systolic flow in the aortic isthmus
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dichotic Listening as a Predictor of Medication Response in Depression
Status: COMPLETED
Conditions: Major Depression|Dysthymia|Depressive Disorder Not Otherwise Specified
Interventions: DRUG: Fluoxetine|DRUG: Imipramine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Identification of Risk for and Prevention of Sickness Absence Due to Musculoskeletal Pain - an RCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Musculoskeletal Disorder
Interventions: OTHER: PREVSAM model|OTHER: Treatment as usual (standard treatment)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioequivalence Study of Lamotrigine Tablets 25 mg (2 x 25 mg Tablets) Under Fed Condition
Status: COMPLETED
Conditions: Fed
Interventions: DRUG: Lamotrigine Tablets 25 mg|DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Laser Therapy and Exercise in Participants With Chronic Low Back Pain
Status: UNKNOWN
Conditions: Low Back Pain (LBP)
Interventions: DEVICE: exercise + photobiomodulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multiple Ascending Dose Study in Healthy Male Subjects and Overweight to Obese Male and Female Type 2 Diabetes Mellitus (T2DM) Patients
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: SAR425899|DRUG: placebo|DRUG: metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
Status: COMPLETED
Conditions: Hepatic Impairment
Interventions: DRUG: Brensocatib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of VSL#3 on Metabolic, Endocrine, Lipidomic and Inflammatory Parameters of Pediatric Patients With BMI>90°
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: VSL#3 active probiotic|OTHER: VSL#3 placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase II Neoadjuvant Pyrotinib Combined With Neoadjuvant Chemotherapy in HER2-low-expressing and HR Positive Early or Locally Advanced Breast Cancer: a Single-arm, Non-randomized, Single-center, Open Label Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer|HER2-low-expressing Breast Cancer|Hormone Receptor-positive Breast Cancer|Neoadjuvant Therapy
Interventions: DRUG: Pyrotinib + epirubicin and cyclophosphamide followed by docetaxel treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Botulinum Toxin Injection in the UES for R-CPD
Status: NOT_YET_RECRUITING
Conditions: Retrograde Cricopharyngeus Dysfunction
Interventions: DRUG: botulinum toxin type A|DRUG: Sodium Chloride 0.9% Inj
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Catheter Ablation in Atrial Fibrillation Patients With HFpEF (STABLE-SR IV Trial)
Status: RECRUITING
Conditions: Atrial Fibrillation|HFpEF - Heart Failure With Preserved Ejection Fraction
Interventions: PROCEDURE: Radiofrequency catheter ablation (RFCA)|DRUG: Medical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Renin Angiotensin System Blockade on the Fas Antigen (CD95) and Asymmetric Dimethylarginine (ADMA) Levels in Type-2 Diabetic Patients With Proteinuria
Status: COMPLETED
Conditions: Proteinuria|Diabetic Nephropathy|Chronic Kidney Disease
Interventions: DRUG: ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: CBA Versus FBA Conditioning Followed by Haploidentical Allogeneic HSCT in Treatment of High Risk and Refractory AML
Status: UNKNOWN
Conditions: High Risk Acute Myeloid Leukemia|Allogeneic Hematopoeitic Stem Cell Transplantation
Interventions: DRUG: Cladribine|DRUG: Fludarabine|DRUG: Busulfan|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of NMES With Pelvic Fracture Rehabilitation
Status: COMPLETED
Conditions: Fractures, Closed
Interventions: DEVICE: Treatment NMES|DEVICE: Placebo NMES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multiple-Dose Pharmacokinetic Interaction Study Between ABT-335, Atorvastatin and Ezetimibe
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: ABT-335|DRUG: Atorvastatin|DRUG: Ezetimibe
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Ivabradine on Patients With Postural Tachycardia Syndrome
Status: UNKNOWN
Conditions: Postural Tachycardia Syndrome
Interventions: DRUG: ivabradine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Utility Evidence for TissueCypher®
Status: COMPLETED
Conditions: Gastro-Intestinal Disorder|Barrett Esophagus
Interventions: OTHER: Educational materials for TissueCypher
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: DIAGNOSTIC
Clinical trial: Combined Anodal Transcranial Direct Current Stimulation (tDCS) and Cognitive Training and Decision-making
Status: RECRUITING
Conditions: Impulsivity|Decision Making
Interventions: OTHER: Anodal transcranial Direct Current Stimulation (tDCS)|BEHAVIORAL: Cognitive training|OTHER: Sham transcranial Direct Current Stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: Vitamin E|DRUG: Diclofenac Sodium|DRUG: Piroxicam|DRUG: Tramadol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Higher and Standard Doses of Enteral Zinc Supplementation in Very Preterm Infants
Status: ENROLLING_BY_INVITATION
Conditions: Very Preterm Infants|Zinc Deficiency
Interventions: DIETARY_SUPPLEMENT: Higher dose of enteral zinc|DIETARY_SUPPLEMENT: Standard dose of enteral zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 3D-Printed Vs Thermoformed Retainers: Comparison of Post-Treatment Stability, Changes in Mechanical Properties and Patients' OHRQoL
Status: RECRUITING
Conditions: Orthodontic Retention
Interventions: DEVICE: Thermoformed retainers|DEVICE: 3D-printed retainers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: A Study of Insulin Lispro With BioChaperone Excipient in Healthy Participants
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: Insulin Lispro|DRUG: BC106 insulin lispro
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Bilateral Serratus Intercostal Plane Block for Myocardial Revascularization (SERRINT)
Status: UNKNOWN
Conditions: Pain, Postoperative|Pain Management|Analgesia, Patient-Controlled|Nerve Block
Interventions: OTHER: Bilateral serratus Intercostal plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Does a Ketogenic Dietary Supplement Reduce Alcohol Withdrawal Symptoms in Humans?
Status: UNKNOWN
Conditions: Alcohol Use Disorder|Alcohol Withdrawal|Ketosis
Interventions: DIETARY_SUPPLEMENT: H.V.M.N. Ketone Ester|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of JNJ-47910382 at Different Doses and Dose Regimens in Asian Genotype-1, Chronic, HCV-Infected Patients
Status: TERMINATED
Conditions: Chronic Hepatitis C Infection
Interventions: DRUG: JNJ-47910382 30 mg|DRUG: JNJ-47910382 90 mg|DRUG: JNJ-47910382 200 mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proton Pump Inhibitor (PPI) Responsive Eosinophilic Esophagitis EoE: Gastroesophageal Reflux Disease (GERD) or Eosinophilic Esophagitis (EoE)?
Status: COMPLETED
Conditions: Erosive Esophagitis
Interventions: RADIATION: Esophageal Barium Xray
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Surgical Treatment To Greater Anterior Vaginal Prolapse
Status: UNKNOWN
Conditions: Hernia|Cystocele
Interventions: PROCEDURE: Surgical treatment of Anterior Vaginal Prolapse|DEVICE: NAZCA TC™ POP REPAIR SYSTEM ,promedon® , argentina.|PROCEDURE: surgical treatment for anterior vaginal wall prolapse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Cetuximab With and Without Weekly Paclitaxel for Patients With Previously Treated Advanced Urothelial Cancer
Status: COMPLETED
Conditions: Urologic Neoplasm
Interventions: DRUG: Cetuximab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT