pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Pharmacokinetic Study of IMM0306 in Patients With Refractory or Relapsed CD20-positive B-cell Non-Hodgkin's Lymphoma (B-NHL)
Status: SUSPENDED
Conditions: B-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: IMM0306
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Montelukast in Exercise-Induced Bronchospasm - 2003 (0476-270)
Status: COMPLETED
Conditions: Asthma, Exercise-Induced
Interventions: DRUG: Comparator: Montelukast|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Left Bundle Branch Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy
Status: COMPLETED
Conditions: Chronic Heart Failure
Interventions: PROCEDURE: Left bundle branch pacing|PROCEDURE: Biventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Durvalumab and Tremelimumab After Radioembolization for the Treatment of Unresectable, Locally Advanced Liver Cancer
Status: RECRUITING
Conditions: BCLC Stage B Hepatocellular Carcinoma|BCLC Stage C Hepatocellular Carcinoma|Locally Advanced Hepatocellular Carcinoma|Stage III Hepatocellular Carcinoma AJCC v8|Stage IIIA Hepatocellular Carcinoma AJCC v8|Stage IIIB Hepatocellular Carcinoma AJCC v8|Stage IV Hepatocellular Carcinoma AJCC v8|Stage IVA Hepatocellular Carcinoma AJCC v8|Stage IVB Hepatocellular Carcinoma AJCC v8|Unresectable Hepatocellular Carcinoma
Interventions: BIOLOGICAL: Durvalumab|BIOLOGICAL: Tremelimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of Formulation and Tablet Hardness on the Bioavailability of Pictilisib in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: GDC-0941|DRUG: GDC-0941|DRUG: GDC-0941|DRUG: GDC-0941
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Behavior Therapy for Posttraumatic Headache
Status: COMPLETED
Conditions: Post-traumatic Headache|PTSD
Interventions: BEHAVIORAL: Behavioral Headache Therapy|BEHAVIORAL: Cognitive Processing Therapy|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychosocial and Economic Impacts of Narrative Exposure Therapy for Violence Survivors in Eastern DRC
Status: COMPLETED
Conditions: Mental Health Disorder|PTSD|Depression Anxiety Disorder|Gender-based Violence
Interventions: BEHAVIORAL: NET Treatment|OTHER: Alternative Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Freespira Breathing System in the Treatment of Post Traumatic Stress Disorder (PTSD)
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic
Interventions: DEVICE: Freespira Breathing System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Acquiring Hyperpolarized Imaging in Patients With Primary CNS Lymphoma
Status: RECRUITING
Conditions: Primary CNS Lymphoma
Interventions: DRUG: Hyperpolarized pyruvate (13C)|PROCEDURE: Magnetic resonance imaging (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Effectiveness of rMV (Repeated Muscle Vibration) in Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DEVICE: repeated Muscle Vibration (rMV) (Cro ® System)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: External Trigeminal Nerve Stimulation for Epilepsy
Status: COMPLETED
Conditions: Epilepsy|Seizure Disorders
Interventions: DEVICE: Trigeminal Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gene-Activated® Human Glucocerebrosidase (GA-GCB) ERT Compared With Imiglucerase in Type I Gaucher Disease
Status: COMPLETED
Conditions: Gaucher Disease, Type 1
Interventions: BIOLOGICAL: velaglucerase alfa|BIOLOGICAL: imiglucerase
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarkers of Response to Ipilimumab and Nivolumab in First-line NSCLC
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: Ipilimumab|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre and or Post Operative Blood Pressure Control With Clevidipine (Cleviprexm Medicines Company) in Aortic Aneurysm / Dissection
Status: WITHDRAWN
Conditions: Aorta Aneurysm|Dissection of Aorta
Interventions: DRUG: Clevidipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multicomponent Physical Activity Intervention for the Reduction of Psychosocial Distress in Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Anxiety Disorder|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Early Chest Tube Removal After Surgery for Primary Spontaneous Pneumothorax: A Randomized Controlled Trial
Status: RECRUITING
Conditions: Primary Spontaneous Pneumothorax
Interventions: PROCEDURE: Early Chest Tube Removal|PROCEDURE: Standard Chest Tube Removal|DEVICE: Apical Chest Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Patients With Locoregionally Advanced Esophageal Squamous Cell Carcinoma
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Docetaxel plus cisplatin|RADIATION: radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ISOperistaltic Versus ANTIperistaltic Anastomosis After Laparoscopic Right Colectomy for Cancer
Status: COMPLETED
Conditions: Primary Malignant Neoplasm of Ascending Colon
Interventions: PROCEDURE: antiperistaltic side-to-side ileocecal anastomosis|PROCEDURE: isoperistaltic side-to-side ileocecal anastomosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: DCP3 Based Multi-component Intervention for Hypertension Management and Control
Status: COMPLETED
Conditions: Hypertension|Hypertensive Patients
Interventions: BEHAVIORAL: Intervention on DCP3 based strategies for Hypertension Management and Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Continuous Versus Cyclic Oral Contraceptives for Endometriosis
Status: UNKNOWN
Conditions: Dysmenorrhea|Pelvic Pain|Dyspareunia|Endometrioma
Interventions: DRUG: Oral contraceptives cyclic|DRUG: Oral contraceptives continuous
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: G-CSF and Autologous Cord Blood Infusion in Cerebral Palsy
Status: UNKNOWN
Conditions: Cerebral Palsy
Interventions: DRUG: G-CSF (Leucostim)|BIOLOGICAL: CB (autologous cord blood)|DRUG: Placebo (Normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Temporary Spur Stent for the Treatment of Narrowing and Blockages in the Arteries Below the Knee
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Arterial Disease
Interventions: DEVICE: Temporary Spur Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-6231 in Healthy Adults
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: mRNA-6231
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Study of Livalo® Fixed Combination Drug in Healthy Subjects
Status: COMPLETED
Conditions: Hyperlipidemia|Hypertension
Interventions: DRUG: Pitavastatin, Valsartan|DRUG: Livalo® fixed combination drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Inhalational (Sevoflurane) Versus Intravenous (Propofol) Sedation in Adults With a Moderate Form of ARDS
Status: SUSPENDED
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: Sevoflurane|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The More & Less Study: A Trial Testing Different Treatment Approaches to Obesity in Preschoolers
Status: COMPLETED
Conditions: Obesity
Interventions: BEHAVIORAL: Parent training group|BEHAVIORAL: Standard treatment with focus on lifestyle|BEHAVIORAL: Parent training group with booster sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intrauterine Misoprostol Versus Rectal Misoprostol in Reducing Blood Loss During Cesarean Section
Status: UNKNOWN
Conditions: Hemorrhage, Postpartum
Interventions: DRUG: Misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Tolerability of Treatment With Lanthanum Carbonate in Patients With End Stage Renal Disease Receiving Dialysis
Status: COMPLETED
Conditions: Kidney Failure, Chronic
Interventions: DRUG: Lanthanum carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Repetitive Transcranial Magnetic Stimulation for Poststroke Dysphagia Recovery
Status: UNKNOWN
Conditions: Stroke|Dysphagia
Interventions: DEVICE: rTMS, Magstim Rapid2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biomarker Changes in Samples From Young Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: DNA methylation analysis|GENETIC: gene expression analysis|GENETIC: microarray analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Intermediate or Prophylactic-Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19
Status: COMPLETED
Conditions: COVID-19|Venous Thromboses|Arterial Thrombosis
Interventions: DRUG: Enoxaparin Prophylactic Dose|DRUG: Heparin Infusion|DRUG: Heparin SC|DRUG: Enoxaparin/Lovenox Intermediate Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial
Status: WITHDRAWN
Conditions: Cancer of Head and Neck|Mucositis Oral|Pharyngeal Mucositis
Interventions: DRUG: Ketamine Topical
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cannabis Vs Opioids Pain Management Objective Testing Comparisons
Status: NOT_YET_RECRUITING
Conditions: Chronic Pain|Circulatory Disorders
Interventions: DEVICE: Monochromatic Infrared Photo Energy (MIRE)|DEVICE: Transcutaneous Electrical Nerve Stimulation|DRUG: Opioids|DRUG: Cannabis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Circadian Rhythm Disruption Effects on Smoke Inhalation
Status: COMPLETED
Conditions: Inflammation|Sleep Deprivation|Circadian Rhythm Sleep Disorder, Shift Work Type|Smoke Inhalation
Interventions: BEHAVIORAL: Sleep Restriction|BEHAVIORAL: Normal Sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of TMC435 in Genotype 1, Hepatitis C-infected Patients Who Relapsed After Previous Interferon (IFN)-Based Therapy
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: TMC435|DRUG: Pegylated interferon (pegIFN alpha-2a)|DRUG: Ribavirin (RBV)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study B
Status: COMPLETED
Conditions: Sleep Apnea, Obstructive
Interventions: DRUG: Desipramine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Human Mesenchymal Stem Cell Injection in PAtieNts With FaceTogenic Back Pain
Status: WITHDRAWN
Conditions: Facetogenic Back Pain|Back Pain
Interventions: BIOLOGICAL: Allogeneic Human Mesenchymal Stem Cells (hMSCs)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: ACPs in Severe PAD/CLI by Direct Intramuscular Injection
Status: COMPLETED
Conditions: Peripheral Arterial Disease|Critical Limb Ischemia
Interventions: PROCEDURE: Angiogenic Cell Precursors (ACPs) or Vescell TM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Absorb GT1 Japan PMS
Status: COMPLETED
Conditions: Ischemic Heart Disease|Angina Pectoris|Coronary Artery Disease|Coronary Artery Occlusion|Myocardial Ischemia
Interventions: DEVICE: ABSORB GT1 BVS
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Postoperative Pain Control Using Local Wound Infiltration in Adolescent Idiopathic Surgery
Status: RECRUITING
Conditions: Postoperative Pain|Spinal Fusion
Interventions: PROCEDURE: Local infiltration with 0.25% bupivacaine and epinephrine|PROCEDURE: Placebo of equal volume injectable saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions
Status: COMPLETED
Conditions: Atherosclerosis|Cardiovascular Diseases|Hypertension, Renovascular|Renal Artery Obstruction
Interventions: DRUG: Atacand/HCT, Caduet|PROCEDURE: GENESISTM Embolic Protection Stent and Angioguard Device (Angioplasty plus stenting)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Fenofibrate and Metformin for Atherogenic Dyslipidemia (FAMA) Study
Status: COMPLETED
Conditions: Metabolic Syndrome x
Interventions: DRUG: Study drugs: Metformin and fenofibrate|DRUG: Study Drug: Metformin|DRUG: Study Drug: fenofibrate|DRUG: Metformin and Fenofibrate placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Skull Base and Low Grade Glioma Neurocognitive Magnetic Resonance Imaging (MRI) Study
Status: COMPLETED
Conditions: Malignancy|Glioma|Radiotherapy
Interventions: RADIATION: Photon treatment plans|RADIATION: Proton Treatment Plans|BEHAVIORAL: Neurocognitive evaluation|DEVICE: Advanced MRI imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Neuromodulation by Non-invasive Brain Stimulation
Status: UNKNOWN
Conditions: Healthy|Transcranial Magnetic Stimulation|Transcranial Direct Current Stimulation
Interventions: OTHER: MRI + transcranial Magnetic Stimulation|OTHER: transcranial electric stimulation + electroencephalogram
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Hydrophilic Acrylic Intraocular Lens
Status: WITHDRAWN
Conditions: Cataract Extraction
Interventions: DEVICE: 2 HEMA Hydrophilic Acrylic Intraocular Lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effect of Concord Grape Juice on Cognitive Function in Mums of Preteen Children
Status: COMPLETED
Conditions: Cognition
Interventions: DIETARY_SUPPLEMENT: Grape juice polyphenols
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: Digital hand-held surgical navigation system|DEVICE: Conventional tibial extramedullary alignment system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Chatbot-aid on Promoting Self-management of Men's Health in the Post COVID-19 Era
Status: RECRUITING
Conditions: Benign Prostate Enlargement|Lower Urinary Tract Symptoms|Erectile Dysfunction
Interventions: DEVICE: Chatbot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Protocol Based Treatment for Early and Severe Systemic Sclerosis With (Anti-CD20), Rituximab
Status: COMPLETED
Conditions: Early and Severe Systemic Sclerosis
Interventions: DRUG: Administration of rituximab and methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GLP-1 and Hyperoxia for Organ Protection in Heart Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Disease|Shock, Cardiogenic|Renal Failure|Stroke|Brain Injury|Aortic Valve Disease
Interventions: DRUG: Byetta (Lilly, Exenatide)|DRUG: Conoxia (AGA, oxygen)|DRUG: 20% Human Albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy And Safety of Pneumatic Trabeculoplasty
Status: COMPLETED
Conditions: Primary Open Angle Glaucoma
Interventions: DEVICE: "model 1000 PNT vacuum controller" (the vacuum device for ocular suction)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Chemotherapy Plus Trastuzumab Plus Toripalimab in HER2 Positive Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma
Status: RECRUITING
Conditions: Adenocarcinoma of the Stomach|Adenocarcinoma of Esophagogastric Junction|HER2-positive Gastric Cancer
Interventions: DRUG: Toripalimab|DRUG: Trastuzumab|DRUG: 5-FU, leucovorin, docetaxel, oxaliplatin (FLOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia
Interventions: BIOLOGICAL: therapeutic autologous lymphocytes|DRUG: cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trans-diagnostic Group CBT vs. Standard Group CBT for Depression, Social Anxiety and Agoraphobia/Panic Disorder
Status: COMPLETED
Conditions: Depression, Unipolar|Anxiety Disorder Social|Panic Disorder
Interventions: BEHAVIORAL: UP-CBT|BEHAVIORAL: Standard-CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of the Food Matrix on Iodine Bioavailability
Status: COMPLETED
Conditions: Iodine Bioavailability
Interventions: DIETARY_SUPPLEMENT: Milk|DIETARY_SUPPLEMENT: Fish|DIETARY_SUPPLEMENT: Seaweed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Tolerability and Safety of CARDIOMEMS™ Intracardiac Continuous Cardiac Hemodynamic Monitoring Device in Patients With Cardio Renal Syndrome With Severe Renal Impairment
Status: RECRUITING
Conditions: Heart Failure|Renal Insufficiency
Interventions: DEVICE: Implantation of the CARDIOMEMS™ HF device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Post-authorization Safety Study in Type 2 Diabetic Patients in Saudi Arabia Treated With Empagliflozin to Assess the Incidence of Ketoacidosis, Severe Complications of Urinary Tract Infection, Volume Depletion, and Dehydration
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Empagliflozin|DRUG: Dipeptidyl-peptidase 4 (DPP-4) inhibitors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Busulfan & Melphalan Conditioning for Autologous Stem Cell Transplant (ASCT) and Lenalidomide Maintenance
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Busulfan|DRUG: Melphalan|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Midterm (Min. 3yr) Follow-up of Patients With Single Spiral/Oblique Finger Metacarpal Fracture
Status: COMPLETED
Conditions: Metacarpal Fracture
Interventions: PROCEDURE: Early mobilization|PROCEDURE: Operative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients
Status: COMPLETED
Conditions: Surgical Site Infections|Post Operative Complication
Interventions: DRUG: 2% chlorhexidine gluconate cloths
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Expand Safety and Immunogenicity Data With Shigella Bioconjugate Vaccine (Shigella4V2) in 9-month-old Infants.
Status: NOT_YET_RECRUITING
Conditions: Shigellosis
Interventions: BIOLOGICAL: Shigella4V2|BIOLOGICAL: MenACWY
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Simultaneous vs. Staged Resection of Colorectal Cancer With Synchronous Liver Metastases
Status: RECRUITING
Conditions: Colorectal Cancer|Colorectal Neoplasms Malignant|Liver Metastasis Colon Cancer|Liver Metastases
Interventions: PROCEDURE: Staged resection|PROCEDURE: Simultaneous resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CARDIOLITE-413: A Study for Patients Who Had a PCI for an Acute MI
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Technetium Tc99m Sestamibi
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Radiation Therapy in Treating Patients With Stage II Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: 70.2 Gy 3D-CRT/IMRT|RADIATION: 79.2 Gy 3D-CRT/IMRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mobile Health to Improve Oral Chemotherapy Adherence Among Women With Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage IA Breast Cancer AJCC v8|Anatomic Stage IB Breast Cancer AJCC v8|Anatomic Stage II Breast Cancer AJCC v8|Anatomic Stage IIA Breast Cancer AJCC v8|Anatomic Stage IIB Breast Cancer AJCC v8|Anatomic Stage III Breast Cancer AJCC v8|Anatomic Stage IIIA Breast Cancer AJCC v8|Anatomic Stage IIIB Breast Cancer AJCC v8|Anatomic Stage IIIC Breast Cancer AJCC v8|Localized Breast Carcinoma|Prognostic Stage I Breast Cancer AJCC v8|Prognostic Stage IA Breast Cancer AJCC v8|Prognostic Stage IB Breast Cancer AJCC v8|Prognostic Stage II Breast Cancer AJCC v8|Prognostic Stage IIA Breast Cancer AJCC v8|Prognostic Stage IIB Breast Cancer AJCC v8|Prognostic Stage III Breast Cancer AJCC v8|Prognostic Stage IIIA Breast Cancer AJCC v8|Prognostic Stage IIIB Breast Cancer AJCC v8|Prognostic Stage IIIC Breast Cancer AJCC v8|Triple-Negative Breast Carcinoma|Metastatic Breast Cancer
Interventions: OTHER: Best Practice|OTHER: Informational Intervention|OTHER: Medical Device Usage and Evaluation|OTHER: Quality-of-Life Assessment|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Comparing the Effectiveness of Papain Based Chemico-mechanical Caries Removal Gel and 38% Silver Diamine Fluoride for Treating Active Caries Lesion of Primary Molars
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Caries in Children
Interventions: OTHER: Cera-bur|OTHER: Brix3000|OTHER: E-SDF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Gemcitabine Every 14 Days Versus Every 21 Days in Advanced Non Small Cell Lung Cancer
Status: TERMINATED
Conditions: Non-Small-Cell Lung Cancer
Interventions: DRUG: Pemetrexed|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing Two Techniques of Celiac Plexus Neurolysis for Treatment of Pain in Carcinoma Pancreas
Status: UNKNOWN
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: percutaneous fluoro guided celiac plexus neurolysis|PROCEDURE: EUS guided neurolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Erectile Dysfunction
Status: COMPLETED
Conditions: Erectile Dysfunction|Impotence, Vasculogenic
Interventions: OTHER: Intracavernosal administration of autologous ADRC|PROCEDURE: Liposuction|DEVICE: ADRC isolation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Docusate in Preventing/Treating Constipation in Palliative Care Patients
Status: COMPLETED
Conditions: Constipation|Palliative Care
Interventions: DRUG: Docusate Sodium, Sennoside|DRUG: Sennoside + Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Functional MRI Evaluation of the Effect of Citalopram in Autism Spectrum Disorders
Status: COMPLETED
Conditions: Autism Spectrum Disorders
Interventions: DRUG: Citalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose:
Clinical trial: Bioidentical 'Natural' Hormone Evaluation in Early Menopause
Status: TERMINATED
Conditions: Menopause
Interventions: DRUG: Estradiol , estriol , progesterone|DRUG: estradiol, progesterone|DRUG: estriol, progesterone|DRUG: equine estrogens m-progesteroneacetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Live Attenuated ETEC Vaccine ACE527 With and Without dmLT Adjuvant in Adults
Status: COMPLETED
Conditions: Diarrhea
Interventions: BIOLOGICAL: ACE527|BIOLOGICAL: dmLT|BIOLOGICAL: CeraVacx placebo|BIOLOGICAL: H10407 challenge strain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccination Against High Risk Breast Cancer Using Tumor Derived Heat Shock Protein 70
Status: TERMINATED
Conditions: Breast Neoplasms
Interventions: BIOLOGICAL: Heat Shock Protein 70-peptide complexes (HSP70)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetylated Natural Nucleotides in Treating Hand-foot Syndrome
Status: COMPLETED
Conditions: Hand-foot Syndrome
Interventions: DRUG: Gel containing Acetylated Natural Nucleotides|DRUG: Vehicle Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of NFC-1 in Adolescents With Genetic Disorders Impacting mGluR and ADHD
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: NFC-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors
Status: COMPLETED
Conditions: Colorectal Cancer|Endometrial Cancer|Head and Neck Cancer|Liver Cancer|Lung Cancer|Melanoma (Skin)|Pancreatic Cancer|Testicular Germ Cell Tumor|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: ras peptide cancer vaccine|BIOLOGICAL: sargramostim|DRUG: DetoxPC
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: BRAVE Strategy - Breast Cancer Risk Assessment -achieVing Equity
Status: RECRUITING
Conditions: Breast Cancer
Interventions: OTHER: Intervention plus 12 months maintenance|OTHER: Intervention plus 10 months maintenance|OTHER: Intervention plus 8 months maintenance|OTHER: Intervention plus 6 months maintenance|OTHER: Intervention plus 4 months maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users
Status: COMPLETED
Conditions: Depression|Dual Diagnosis|Drug Addiction
Interventions: DRUG: Creatine monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nutrition and Coping Education for Symptom and Weight Management for Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Obesity
Interventions: BEHAVIORAL: Lifestyle Modification|BEHAVIORAL: Supportive education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Patient Expectations Influence Pain Reduction After Epidural Injections in Patients With Low Back Pain?
Status: UNKNOWN
Conditions: Expectations|Back Pain|Back Pain Lower Back Chronic|Satisfaction, Patient|Injections, Epidural|Injections, Periradicular|Pain, Back
Interventions: PROCEDURE: Epidural Injection|PROCEDURE: Periradicular Injection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Clinical Study on the End Time of Acupuncture and Moxibustion Therapy for Peripheral Facial Paralysis
Status: RECRUITING
Conditions: Peripheral Facial Paralysis
Interventions: OTHER: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Progression Free Survival (PFS) Using Erlotinib for Non-Small-Cell Lung Cancer (NSCLC) in Chinese Population
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Erlotinib|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Random Vibrations on Perception and Balance
Status: COMPLETED
Conditions: Diabetic Neuropathy
Interventions: DEVICE: Vibrating insoles 'on'
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of a New Surgical Treatment of Macular Hole Retinal Detachment in High Myopia
Status: UNKNOWN
Conditions: Macular Holes|Retinal Detachment|High Myopia
Interventions: PROCEDURE: Group 1|PROCEDURE: Group 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hypofractionated Versus Conventional Fractionation Radiotherapy
Status: UNKNOWN
Conditions: Breast Cancer|Radiation Toxicity
Interventions: RADIATION: Conventional radiotherapy|RADIATION: Hypofractionated radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploratory Study to Evaluate the Effect of SYN111 (Rufinamide) in Patients With Generalized Anxiety Disorder (GAD)
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: DRUG: SYN111|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation on HA Coated Dynamic Hip Screws for Trochanteric Femoral Fractures
Status: WITHDRAWN
Conditions: Osteoarthritis
Interventions: DEVICE: Hip Fracture reduction Screw without HA Coating (Hiploc)|DEVICE: Hip Fracture reduction Screw with HA Coating (Hiploc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Lable Randomised Study to Assess the Safety and Efficacy of Short Course Paromomycin in Visceral Leishmaniasis
Status: COMPLETED
Conditions: Visceral Leishmaniasis
Interventions: DRUG: Paromomycin|DRUG: Paromomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dexmedetomidine on Thiol/Disulphide Homeostasis in Coronary Bypass Surgery
Status: NOT_YET_RECRUITING
Conditions: Dexmedetomidine|Oxidative Stress
Interventions: DIAGNOSTIC_TEST: Thiol/Disulphide Homeostasis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Robot-assisted Gait Training on Mobility in Severely Disabled Multiple Sclerosis Patients
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DEVICE: Robot-assisted gait training|OTHER: Conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study on Visco-antalgic Intra-articular Administration in Symptomatic Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: DRUG: JTA-004 intra-articular injection|DEVICE: Reference product intra-articular injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Re-challenge Therapy With Chemotherapy & Panitumumab in Metastatic Colorectal Cancer Patients Treated With an Anti-EGFR
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen Challenge
Status: COMPLETED
Conditions: Cat Allergy|Mild Asthma
Interventions: DRUG: REGN1908-1909|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones
Status: WITHDRAWN
Conditions: Kidney Calculi
Interventions: DRUG: Potassium Citrate|DRUG: Acetazolamide|BEHAVIORAL: Diet low in oxalate and purines
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Phase 1 Study of ABC008 in Ascending (Single Ascending Dose/Multiple Ascending Dose) Study in Patients With (IBM)
Status: ACTIVE_NOT_RECRUITING
Conditions: Inclusion Body Myositis
Interventions: DRUG: ABC008
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Blastic Phase Chronic Myelogenous Leukemia|Childhood Chronic Myelogenous Leukemia|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Relapsing Chronic Myelogenous Leukemia
Interventions: DRUG: imatinib mesylate|DRUG: decitabine|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Ambrisentan in Children 8-18yrs
Status: TERMINATED
Conditions: Hypertension, Pulmonary
Interventions: DRUG: Ambrisentan - low dose|DRUG: Ambrisentan - high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety, Tolerability, and Pharmacokinetics of BFKB8488A in Otherwise Healthy Overweight and Obese Participants With Likely Insulin Resistance
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: BFKB8488A|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Alginate Ag Dressing in the Pressure Injury Patients
Status: COMPLETED
Conditions: Pressure Injury|Long-Term Care
Interventions: OTHER: Alginate silver silver ion dressing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Recombinant Adenovirus AdVince in Patients With Neuroendocrine Tumors; Safety and Efficacy
Status: UNKNOWN
Conditions: Neuroendocrine Tumors
Interventions: DRUG: AdVince
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of the Neck Extension on Blind Intubation Via Ambu® AuraGain™
Status: COMPLETED
Conditions: Intubation; Difficult or Failed|Intubation Complication
Interventions: DEVICE: Ambu® AuraGain™|PROCEDURE: neck extension
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Tolerability Study of Nivolumab and Cabiralizumab for Resectable Biliary Tract Cancer
Status: WITHDRAWN
Conditions: Resectable Biliary Tract Cancer
Interventions: DRUG: Nivolumab|DRUG: Cabrilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Assess Efficacy of cYclosporine Plus Standard of Care in Hospitalized Patients With COVID19
Status: COMPLETED
Conditions: COVID19 Infection
Interventions: DRUG: Cyclosporine|DRUG: Standard treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tecemotide (L-BLP25) in Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: RADIATION: Radiation therapy|DRUG: Goserelin|DRUG: Cyclophosphamide|DRUG: Tecemotide (L-BLP25)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Multiple Dose Trial of GS-9411 in Healthy Volunteers
Status: COMPLETED
Conditions: Cystic Fibrosis|Mucociliary Clearance|Airway Hydration
Interventions: DRUG: GS-9411|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A First in Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of DGX-001
Status: COMPLETED
Conditions: Depressive Disorder
Interventions: DRUG: DGX-001Dose 1|DRUG: DGX-001 Dose 2|DRUG: DGX-001 Dose 3|DRUG: DGX-001 Dose 4|DRUG: MAD dose panel of DGX-001
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Interpectoral+Serratus Anterior Block With Erector Spinae Block in Minimally Invasive Cardiac Surgery
Status: RECRUITING
Conditions: Postoperative Pain
Interventions: PROCEDURE: interpectoral area block + serratus anterior area block group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Improving Self-Regulation Among Adopted Children
Status: WITHDRAWN
Conditions: Self-regulation
Interventions: BEHAVIORAL: Parent-Child Interaction Therapy (PCIT)|BEHAVIORAL: Child-Centered Therapy with Parent Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S1312, Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Leukemia
Status: COMPLETED
Conditions: Acute Leukemias of Ambiguous Lineage|B-cell Adult Acute Lymphoblastic Leukemia|Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Burkitt Lymphoma
Interventions: DRUG: cyclophosphamide|DRUG: vincristine sulfate|DRUG: prednisone|BIOLOGICAL: inotuzumab ozogamicin|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: MRG-110|DRUG: Placebo|DRUG: MRG-110|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pharmacokinetics, Safety, and Tolerability of Ceftazidime-avibactam in Neonates and Infants.
Status: TERMINATED
Conditions: Gram-negative Bacterial Infection
Interventions: DRUG: Part A: Single Dose Ceftazidime-Avibactam, Cohorts 1-3|DRUG: Part B: Multiple-dose Ceftazidime-Avibactam, Cohorts 1-3
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Topical Diclofenac on Macular Thickness After Phacoemulsification
Status: UNKNOWN
Conditions: Diabetic Oculopathy
Interventions: DRUG: Prescribe ARTIFICIAL TEAR|DRUG: Prescribe diclofenac sodium drop 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long-term Effectiveness of Different Dosage Parameters of Early Powered Mobility Training for Toddlers With Motor Delays
Status: RECRUITING
Conditions: Young Children With Motor Disabilities
Interventions: BEHAVIORAL: Ride-On Car Training in a standing posture with a 2-hour session|BEHAVIORAL: Ride-On Car Training in a standing posture with a 1-hour session|BEHAVIORAL: Conventional Therapy with a 1-hour session
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Deep Neck Flexors Training Versus Muscle Energy Technique on Cervicogenic Headache
Status: COMPLETED
Conditions: Cervicogenic Headache
Interventions: OTHER: Deep neck flexors training + Conventional therapy|OTHER: Muscles energy techniques + conventional therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT