pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Peer Delivered, Emotion Regulation-Focused Mental Health Prevention Training for Fire Fighter Trainees
Status: ENROLLING_BY_INVITATION
Conditions: PTSD|Alcohol Use Disorder|Depression|Anxiety
Interventions: BEHAVIORAL: Brief Unified Protocol|BEHAVIORAL: Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Prepandrix™|BIOLOGICAL: Fluarix™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Investigate the Safety, Tolerability, and Preliminary Anti-tumor Activity of Bemcentinib in Combination With Pembrolizumab Plus Pemetrexed and Carboplatin in Adult Participants With Untreated Non-squamous Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Bemcentinib|DRUG: Pembrolizumab|DRUG: Pemetrexed|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Additional Treatment With NMES After Achilles Tendon Rupture
Status: RECRUITING
Conditions: Achilles Tendon Rupture|Physical Disability
Interventions: DEVICE: Neuromuscular electrical stimulation (NMES)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenecteplase in Stroke Patients Between 4.5 and 24 Hours
Status: COMPLETED
Conditions: THROMBOLYSIS
Interventions: BIOLOGICAL: Tenecteplase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Education Using WhatsApp and Face-to-Face Meetings on IYCF for the Nutritional Status of Infants
Status: COMPLETED
Conditions: Nutritional Stunting
Interventions: BEHAVIORAL: Blended education of Infant and Young Child Feeding
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Evaluate Effect of Optison on Pulmonary Artery Systolic Pressure (PASP) and Pulmonary Vascular Resistance (PVR).
Status: COMPLETED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Optison (Perflutren Protein-Type A Microspheres Injectable Suspension)|DRUG: Dextrose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Bridging Study to Eliminate Presence of MRD for Acute Leukemia Before HCT
Status: TERMINATED
Conditions: Leukemia, Acute Lymphoblastic|Acute Myeloid Leukemia
Interventions: DRUG: Clofarabine|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
Status: UNKNOWN
Conditions: Respiratory Failure|Acute Respiratory Failure Requiring Intubation|Pulmonary Edema|Pneumonia|Surgical Wound Infection|Mortality
Interventions: DRUG: Inspiratory oxygen
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of IMMray™ PanCan-d Test for Early Detection of Pancreatic Cancer in High-risk Groups
Status: COMPLETED
Conditions: Pancreatic Ductal Adenocarcinoma|Familial Pancreatic Cancer|FAMMM - Familial Atypical Mole Malignant Melanoma Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Family Based Contingency Management for Adolescent Alcohol Abuse
Status: COMPLETED
Conditions: Alcohol Abuse
Interventions: BEHAVIORAL: Motivational Enhancement Therapy (MET)/CBT+CM|BEHAVIORAL: Motivational Enhancement Therapy (MET)/CBT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cetuximab Plus Biweekly Capecitabine and Oxaliplatin in KRAS Wild Type Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Neoplasm Metastasis
Interventions: DRUG: Cetuximab|DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimizing Strategy of Coronary Revascularization in Patients With Multivessel Lesions Combined Heart Failure
Status: UNKNOWN
Conditions: Heart Failure Due to Coronary Artery Disease
Interventions: PROCEDURE: Coronary Artery Bypass Grafting|PROCEDURE: Percutaneous Coronary Intervention|PROCEDURE: Hybrid Coronary Revascularization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Clinical Trial of the Hemopatch Topic Hemostatic in Cardiac Surgery
Status: COMPLETED
Conditions: Bleeding
Interventions: DEVICE: Hemopatch|BEHAVIORAL: Traditional Hemostasis Techniques (dry or wet gauze compression or similar)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Assess Therapeutic Delay and Resolution of Induced Gingivitis
Status: COMPLETED
Conditions: Gingivitis
Interventions: DRUG: Stannous Fluoride Toothpaste|DRUG: Colgate fluoride toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Haemodynamic Mechanisms and Multicentre Prospective Cohort Study of the Pipeline Flow-diverting Device for the Treatment of Intracranial Aneurysms. Evaluation of the Safety and Efficacy of the Pipeline Flow-diverting Device for the Treatment of Intracranial Aneurysms
Status: ENROLLING_BY_INVITATION
Conditions: Safety Issues
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Immunogenicity and Safety Study of Sabin Inactivated Poliovirus Vaccine (Vero Cell) in 2-month-old Infants
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Investigational sIPV|BIOLOGICAL: Control IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Professional Practices in the Treatment of Refractory Idiopathic Overactive Bladder at the Dose of 50 Units (TOX50IUU)
Status: UNKNOWN
Conditions: Bladder, Overactive
Interventions: DRUG: OnabotulinumtoxinA / Botox®, Allergan Ltd, Irvine, CA, United-States
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma
Status: ACTIVE_NOT_RECRUITING
Conditions: T-cell Lymphoma
Interventions: DRUG: CPI-818
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Inhaled Monodisperse Fluticasone Propionate
Status: COMPLETED
Conditions: Healthy|Asthma
Interventions: DRUG: Fluticasone Propionate_1.5|DRUG: Fluticasone Propionate_3|DRUG: Fluticasone Propionate_6|DRUG: FP From Active 250 ug MDI Inhaler
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Protracted Effect of Combined Nerve Blocks After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Total Knee Arthroplasty|Pain|Nerve Blocks
Interventions: DRUG: Dexamethasone 4 mg + Clonidine 75 microgram + Marcaine 90 mg + Adrenaline 90 microgram|DRUG: Dexamethasone 2 mg + Clonidine 37,5 microgram + Marcaine 45 mg + Adrenaline 45 microgram|DRUG: Ropivacaine + Toradol + Adrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Repetitive Transcranial Magnetic Stimulation in Parkinson&#39;s Disease：A Randomized, Double-blind, Multicenter, Placebo-controlled Trial
Status: NOT_YET_RECRUITING
Conditions: Parkinson Disease|Transcranial Magenetic Stimualtion|Supplementary Motor Area
Interventions: DEVICE: transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Asian Multicenter Prospective Study of ctDNA Sequencing
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer|Ovarian Clear Cell Carcinoma|Nasopharyngeal Carcinoma|Ovarian Cancer|Endometrial Cancer|Triple Negative Breast Cancer
Interventions: GENETIC: NGS analysis of ctDNA
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 3 Study to Evaluate the Efficacy and Safety of Droxidopa on Orthostatic Hypotension Treatment in Hemodialysis Patients
Status: TERMINATED
Conditions: Orthostatic Hypotension
Interventions: DRUG: Droxidopa|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The FibreGum Study - Changing the Course of Obesity in Children
Status: RECRUITING
Conditions: Nutritional and Metabolic Diseases|Child Obesity|Adolescent Obesity
Interventions: DIETARY_SUPPLEMENT: FibreGum|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage III Oropharyngeal Squamous Cell Carcinoma|Stage IVA Oropharyngeal Squamous Cell Carcinoma|Stage IVB Oropharyngeal Squamous Cell Carcinoma|Stage IVC Oropharyngeal Squamous Cell Carcinoma|Tongue Carcinoma
Interventions: DRUG: Cisplatin|RADIATION: IMRT 6 weeks|RADIATION: IMRT 5 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate a 13-valent Pneumococcal Conjugate Vaccine in Infants
Status: COMPLETED
Conditions: Vaccines, Pneumococcal
Interventions: BIOLOGICAL: 13-valent pneumococcal conjugate vaccine|BIOLOGICAL: 7-valent pneumococcal conjugate vaccine|DRUG: Pentavac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: How Accurately Does the Diopsys Visual Evoked Potential (VEP) Vision Testing System Detect Glaucoma?
Status: COMPLETED
Conditions: Glaucoma Diagnosis
Interventions: DIAGNOSTIC_TEST: Optical Coherence Tomography|DIAGNOSTIC_TEST: Visual evoked potential
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Post-operative Cesarean Trial of Pain Control
Status: RECRUITING
Conditions: Post-operative Pain|Cesarean Section
Interventions: DEVICE: ON-Q Pump® with continuous infusion of bupivacaine|DEVICE: ON-Q Pump® with continuous infusion of saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: POOLED Red Blood Cells Prepared From Pooling 5 Leukoreduced, Irradiated RBC Units
Status: WITHDRAWN
Conditions: Transfusion Reaction|Anemia
Interventions: BIOLOGICAL: Standard RBCs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of HIV-1 and Aging on Mucosal Vaccine Responses
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1-infection|Human Immunodeficiency Virus|HIV/AIDS|HIV Infections
Interventions: BIOLOGICAL: Prevnar-13
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Clinical Evaluation of the FluidVision Accommodation Intraocular Lens (AIOL)
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: FluidVision AIOL|DEVICE: AcrySof IQ PanOptix Trifocal IOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Comparison of Darbepoetin Alpha and Recombinant Human Erythropoietin for Treatment of Anemia in Children With Chronic Kidney Disease
Status: COMPLETED
Conditions: Anemia of Chronic Kidney Disease
Interventions: DRUG: Recombinant human erythropoietin|DRUG: Darbepoetin Alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Risperidone|DRUG: Olanzapine|DRUG: Quetiapine|DRUG: Aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Developing and Pilot Testing Culturally Based Educational Videos for Puerto Rican and African American Home Hospice Caregivers
Status: COMPLETED
Conditions: Caregivers of Patients on Hospice Care
Interventions: BEHAVIORAL: Caregiver educational videos
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Effectiveness and Efficacy of the PowerSleep Device
Status: COMPLETED
Conditions: Sleep|Sleep Disorders Not Due to A Substance or Known Physiological Condition
Interventions: DEVICE: Powersleep|DEVICE: Sham Powersleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Artery Denervation in Chronic Heart Failure Study
Status: UNKNOWN
Conditions: Chronic Systolic Heart Failure
Interventions: PROCEDURE: Renal Denervation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Fasting Strategies on Postoperative Recovery and Long-term Prognosis in Patients With Colorectal Cancer
Status: UNKNOWN
Conditions: Fasting|Immune Suppression|Complication of Surgical Procedure|Colorectal Cancer
Interventions: BEHAVIORAL: Fasting hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Insulin Delivery In Type 1 Diabetes Pregnancies (CIRCUIT)
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes Mellitus|Pregnancy Related|Glucose Metabolism Disorders|Metabolic Disease|Endocrine System Diseases
Interventions: DEVICE: Tandem t:slim X2 insulin pump with Control IQ technology
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Vestibular Schwannoma|Acoustic Neuroma
Interventions: RADIATION: Fractionated proton radiation|DRUG: Losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Well Different Doses of BI 1815368 Are Tolerated by Healthy Men
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1815368|DRUG: Matching placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Is Medicinal Cannabis an Effective Treatment for Tourette Syndrome in Adolescents? A Pilot Study
Status: COMPLETED
Conditions: Tourette Syndrome in Adolescence
Interventions: DRUG: Medicinal cannabis (MC): THC 10mg/mL : CBD 15mg/mL, manufactured by Cann Group Ltd.|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Spinal Cord Stimulation for Gait Disorders in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease|Gait Disorders, Neurologic
Interventions: PROCEDURE: Implantation of electrodes for Spinal cord stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intensified vs. Standard Dose Therapy With Mycophenolate Sodium Plus Cyclosporin Microemulsion and Corticosteroid Combination in Patients With de Novo Renal Transplant Patients
Status: COMPLETED
Conditions: Renal Transplantation
Interventions: DRUG: Enteric-coated mycophenolate sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Learning Approach (ISLA)
Status: RECRUITING
Conditions: Opioid Misuse
Interventions: BEHAVIORAL: Instructional Skill-Building Learning Approach (ISLA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study of BMS-188667 (CTLA4Ig) in Patients With Psoriasis Vulgaris
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: Abatacept
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma
Status: RECRUITING
Conditions: Adult Gliomas, Mixed
Interventions: DRUG: Hyperpolarized Carbon 13 Alpha-ketoglutarate (HP C13-aKG)|PROCEDURE: Magnetic Resonance Image (MRI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Effect Single and Multiple Oral Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Amitriptyline and Nortriptyline in Healthy Male and Female Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIRT 2584 XX|DRUG: Amitriptyline
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial
Status: COMPLETED
Conditions: Traumatic Brain Injury|Transfusion
Interventions: PROCEDURE: Red Blood Cells Transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CERENOVUS Neurothrombectomy Devices Registry
Status: RECRUITING
Conditions: Cerebral Stroke
Interventions: DEVICE: EmboTrap® Revascularization Device|DEVICE: CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter|DEVICE: CEREGLIDE 71 Intermediate Catheter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Predictive Value of Diffusion-weighted MRI Performed in Early Post-treatment in the Occurrence of Tumor Recurrence or Progression in Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy: a Pilot Study
Status: COMPLETED
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: OTHER: diffusion-weighted MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Administration of Combined Enteral Lactoferrin and Probiotic On Invasive Fungal Infections In Preterm Neonates
Status: COMPLETED
Conditions: Fungal Infection
Interventions: DRUG: Lactoferrin Bovine|COMBINATION_PRODUCT: Lactoferrin Bovine and probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: PRedictive Accuracy of Initial Stone Burden Evaluation.
Status: ENROLLING_BY_INVITATION
Conditions: Urolithiasis|Ureterolithiasis|Nephrolithiasis
Interventions: DIAGNOSTIC_TEST: Computed Tomography, CSD|DIAGNOSTIC_TEST: Computed Tomography, SA|DIAGNOSTIC_TEST: Computed Tomography, 3D
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Leiomyosarcoma|Liposarcoma|Sarcoma G2|Sarcoma G3|Soft Tissue Sarcoma|Soft Tissue Sarcoma of the Trunk and Extremities|Stage I Soft Tissue Sarcoma AJCC v7|Stage II Soft Tissue Sarcoma AJCC v7|Undifferentiated Pleomorphic Sarcoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Magnetic Resonance Imaging|RADIATION: Radiation Therapy|BIOLOGICAL: Talimogene Laherparepvec
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pramipexole Versus Placebo in Parkinson's Disease (PD) Patients With Depressive Symptoms
Status: COMPLETED
Conditions: Parkinson Disease|Depression
Interventions: DRUG: Pramipexole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Phototherapy Device to Treat Patients With Crigler-Najjar Disease
Status: UNKNOWN
Conditions: Crigler Najjar Syndrome|Children
Interventions: DEVICE: Arm1 homemade phototherapy treatment|DEVICE: DRAP
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Comparison of Azilsartan Medoxomil to Valsartan in Participants With Essential Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Azilsartan Medoxomil|DRUG: Azilsartan Medoxomil|DRUG: Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Specified Drug-Use Survey of Leuprorelin Acetate Injection Kit 11.25 mg "All-Case Investigation: Spinal and Bulbar Muscular Atrophy (SBMA)"
Status: RECRUITING
Conditions: Spinal and Bulbar Muscular Atrophy
Interventions: DRUG: Leuprorelin Acetate
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acute Leukemia Undergoing Chemotherapy
Status: COMPLETED
Conditions: Acute Leukemia|Anorexia|Anxiety|Depression|Dyspnea|Insomnia|Nausea|Pain
Interventions: PROCEDURE: Aromatherapy and Essential Oils|OTHER: Placebo|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery
Status: RECRUITING
Conditions: Chronic Post Operative Pain|Oxycodone|Pregabalin|Postoperative Complications
Interventions: DRUG: Oxycodone and Pregabalin|DRUG: Oxycodone and placebo capsules|DRUG: Pregabalin and NS|DRUG: placebo capsules and NS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Measurement of Alanine Aminotransaminase (ALT) Following Initiation of Antidiabetic Agents in Patients With Type 2 Diabetes in a Real-world Clinical Setting: a Retrospective Cohort Study
Status: COMPLETED
Conditions: T2DM (Type 2 Diabetes Mellitus)|Fatty Liver|NAFLD
Interventions: OTHER: Non-interventional
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ultrasound Evaluation of the Vascular Anatomy of the Neck to Minimize the Accidental Risk of Vascular Puncture During Percutaneous Tracheostomy
Status: COMPLETED
Conditions: Tracheostomy Complication|Trachea
Interventions: DIAGNOSTIC_TEST: Neck ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of JNJ-87704916, as Monotherapy and in Combination for Advanced Solid Tumors
Status: RECRUITING
Conditions: Advanced Solid Tumors
Interventions: DRUG: JNJ-87704916|DRUG: Cetrelimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Couple HOPES (Helping Overcome PTSD and Enhance Satisfaction)
Status: COMPLETED
Conditions: Posttraumatic Stress Disorder
Interventions: BEHAVIORAL: Couple HOPES Guided, Internet-Delivered, Self-Help Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Pharmacokinetic (PK), Safety and Tolerability of GSK2894512 in Healthy Adult Subjects
Status: WITHDRAWN
Conditions: Psoriasis
Interventions: DRUG: GSK2894512 1% CREAM|DRUG: GSK2894512 MATCHING VEHICLE CREAM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 2 Study of Vinblastine in Children With Recurrent or Refractory Low Grade Glioma
Status: COMPLETED
Conditions: Glioma
Interventions: DRUG: vinblastine sulphate injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Non-invasive Brain Stimulation and Exercise to Treat Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: DEVICE: Active rTMS|DEVICE: Sham rTMS|OTHER: Motor Control Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Two Multimodal-programs of Exercises in Male Soccer Players.
Status: COMPLETED
Conditions: Sports Physical Therapy
Interventions: OTHER: IAI Exercises Protocol|OTHER: FIFA 11+
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Scalp Application of LED Therapy to Improve Thinking and Memory in Veterans With Gulf War Illness
Status: COMPLETED
Conditions: Gulf War Veterans Illness|Neurobehavioral Manifestations|Memory Disorders
Interventions: DEVICE: Real LED Treatment|DEVICE: Sham LED Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Tracheal Tube Size Affect Patient's Experience of Postoperative Sore Throat and Hoarseness
Status: COMPLETED
Conditions: Sore Throat|Hoarseness
Interventions: DEVICE: Smaller tube size
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)
Status: COMPLETED
Conditions: B-cell Malignancies|Colorectal Cancer (CRC)|Head and Neck Cancer|Lung Cancer|Lymphoma|Melanoma|Ovarian Cancer|Glioblastoma
Interventions: DRUG: Nivolumab|DRUG: Epacadostat|DRUG: Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Glutathione in Mild Cognitive Impairment
Status: RECRUITING
Conditions: Mild Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Glycine|DIETARY_SUPPLEMENT: N-acetylcysteine (NAC)|DIETARY_SUPPLEMENT: Alanine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting
Status: TERMINATED
Conditions: Nausea and Vomiting
Interventions: DRUG: Cesamet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interscalene Brachial Plexus Block Washout to Reverse Inadvertent Phrenic Nerve Blockade
Status: COMPLETED
Conditions: Anesthesia, Local|Phrenic Nerve Paralysis|Upper Extremity Injury|Phrenic Nerve Palsy on the Left|Phrenic Nerve Palsy on the Right
Interventions: PROCEDURE: Normal saline injected via interscalene nerve catheter|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Glucosamine and Chondroitin for Aromatase Inhibitor Induced Joint Symptoms in Women With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Joint Pain
Interventions: DRUG: Chondroitin|DRUG: Glucosamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Benefit of Permanent Stimulation of the Left Branch of the His Bundle Versus Right Ventricular Stimulation After Atrioventricular Node Ablation for Rapid Atrial Fibrillation
Status: RECRUITING
Conditions: Atrial Fibrillation Rapid
Interventions: PROCEDURE: left bundle branch of His pacing|PROCEDURE: right ventricular pacing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Infliximab Treatment Along With Pegylated Interferon and Ribavirin in the Treatment of Hepatitis C
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Infliximab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Status: UNKNOWN
Conditions: X-Linked Combined Immunodeficiency Diseases
Interventions: BIOLOGICAL: CD34+ HSCs transduced with the lentivirus vector, VSV-G pseudotyped CL20-4i-EF1α-hγc-OPT|DRUG: Palifermin|DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Technique for Uterine Incision Closure at The Time of Cesarean Section: Does it Make a Difference
Status: COMPLETED
Conditions: Cesarean Section|Wound Dehiscence
Interventions: PROCEDURE: double layer step up-step down technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Salvage Brachytherapy and Hyperthermia for Recurrent H&N-tumours
Status: RECRUITING
Conditions: Locally Recurrent Head and Neck Cancer
Interventions: RADIATION: Brachytherapy|OTHER: Hyperthermia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study Evaluating Heart and Lung Metabolism in Pulmonary Hypertension Associated With Left Heart Disease
Status: TERMINATED
Conditions: Pulmonary Hypertension
Interventions: RADIATION: FDG PET scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Amifampridine on Neuromuscular Transmission in Patients Treated With OnabotulinumtoxinA
Status: RECRUITING
Conditions: Botulism|Iatrogenic Botulism
Interventions: DRUG: Amifampridine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Iodine-124 (I-124) and Iodine-131 (I-131) Radiopharmacokinetics in Patients Prepared With Recombinant Human TSH Injection (rhTSH)
Status: TERMINATED
Conditions: Thyroid Cancer
Interventions: RADIATION: Radioactive Iodine 124
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Use of Total-Body PET to Quantify Systemic and Cutaneous Inflammation in Psoriasis Patients Before and After Intervention With a Nutritionally Balanced Diet
Status: RECRUITING
Conditions: Psoriasis
Interventions: BEHAVIORAL: Dietary Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Administration of Antioxidants to Infertile Men and Sperm Quality
Status: COMPLETED
Conditions: Male Infertility
Interventions: OTHER: Spermotrend
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Trial of Tamoxifen and 4-HPR (4-N-Hydroxyphenyl Retinamide) in Persons at High Risk for Developing Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Breast Neoplasms
Interventions: DRUG: fenretinide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Semaglutide for Post-Smoking Cessation Weight Management
Status: RECRUITING
Conditions: Obesity|Overweight|Cigarette Smoking
Interventions: DRUG: semaglutide 2.4mg|DRUG: Placebo|DRUG: Nicotine Replacement Therapy (NRT, nicotine patch)|BEHAVIORAL: Brief Smoking Cessation Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofractionated Versus Conventionally Fractionated Preoperative Radiation Followed by Mastectomy With Immediate Autologous Breast Reconstruction With Integrated Nanomechanical Biomarker Evaluation
Status: RECRUITING
Conditions: Breast Cancer
Interventions: RADIATION: Group 1 (preoperative radiation hypofractionated)|OTHER: Group 2 (preoperative radiation conventionally fractionated)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Specific Guides and Surgical Planning for Periacetabular Osteotomy; Post Marketing Evaluation Study
Status: RECRUITING
Conditions: Pelvic Osteotomy|Acetabular Dysplasia|Periacetabular Osteotomy
Interventions: DEVICE: MyPAO
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Adebrelimab Plus Apatinib for Participants With HCC at High-risk of Recurrence After Curative Resection
Status: RECRUITING
Conditions: Carcinoma, Hepatocellular
Interventions: DRUG: Adebrelimab + Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Dry Eye by Tear Film Imager in a Low Humidity Environmental Exposure Chamber (TFI-LH16)
Status: COMPLETED
Conditions: Dry Eye
Interventions: DIAGNOSTIC_TEST: Tear Film Imager|DIAGNOSTIC_TEST: Low Humidity Environmental Exposure Chamber (LH-EEC)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Pharmacist Impact on Pneumococcal Polysaccharide Vaccination Rates in Patients With Diabetes in a Supermarket Pharmacy Chain
Status: COMPLETED
Conditions: Pneumococcal Pneumonia
Interventions: BEHAVIORAL: Pharmacist Vaccine Education
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Immunogenicity of a Candidate MERS-CoV Vaccine (MERS001)
Status: TERMINATED
Conditions: MERS (Middle East Respiratory Syndrome)
Interventions: BIOLOGICAL: ChAdOx1 MERS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers
Status: COMPLETED
Conditions: Nicotine Dependence, Other Tobacco Product|Bladder Cancer|Lung Cancer|Cancer of Head and Neck
Interventions: DEVICE: HALO
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in the Treatment of Acute Spinal Cord Injury (SCI)
Status: COMPLETED
Conditions: Spinal Cord Injuries
Interventions: PROCEDURE: CSF Drainage|PROCEDURE: No CSF Drainage
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Phase 3, Open-label Study to Investigate the Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2, 3 and 4 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults
Status: COMPLETED
Conditions: Chronic Hepatitis C|Human Immunodeficiency Virus
Interventions: DRUG: Sofosbuvir|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Subcutaneous and Intravenous Velcade in Combination With Dexamethasone in Chinese Subjects With Relapsed and Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Ixabepilone in Metastatic Breast Cancer and Its Effects on the Ultrastructure of Neurons
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: ixabepilone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dorsal Versus Volar Approach for CapFlex-PIP© Implantation
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: PROCEDURE: Dorsal approach CapFlex arthroplasty|PROCEDURE: Volar approach CapFlex arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Pemetrexed Plus Carboplatin Combined With Radiation in Patients With Inoperable Locally Advanced Non-small Cell Lung Cancer (LA-NSCLC) (RT0801)
Status: UNKNOWN
Conditions: Non-Small Cell Lung Cancer
Interventions: DRUG: pemetrexed|DRUG: carboplatin|RADIATION: thoracic radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapeutic Agents in Brain/Breast
Status: COMPLETED
Conditions: Breast Cancer|Metastatic Cancer
Interventions: DRUG: capecitabine|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: gemcitabine hydrochloride|DRUG: lapatinib ditosylate|DRUG: paclitaxel|DRUG: vinorelbine ditartrate|DRUG: Trastuzumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Post-operative Sensitivity of Bulk Fill Resin Composite Versus the Nano Resin Composite.
Status: COMPLETED
Conditions: Sensitivity
Interventions: OTHER: Bulk fill composite|OTHER: Nano resin composite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diet, Immunometabolism and Non-alcoholic Fatty Liver Disease
Status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease|Liver Fat|Obesity|Inflammation
Interventions: BEHAVIORAL: Standard healthy eating advice|BEHAVIORAL: eTRE plus Mediterranean diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tearing of Membranes Before Birth - a Comparison Between Two Ways of Induction of Labor Pitocin Opposite Prostaglandin
Status: UNKNOWN
Conditions: Fetus or Newborn or Maternal; Effects of Induction of Labor
Interventions: DRUG: Intravenous oxytocin|DRUG: vaginal prostaglandin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Parental Perception of Their Child's Emotional Quality of Life in Paediatric Oncology Before and After "Magic Massages"
Status: NOT_YET_RECRUITING
Conditions: Acute Lymphoblastic Leukemia, Pediatric
Interventions: OTHER: Self-report questionnaires (only for parents)|OTHER: Interview (only for parents)|OTHER: Clinical data collection (only concerning Children)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Monitoring Postoperative Patient-controlled Analgesia (PCA)
Status: RECRUITING
Conditions: Postoperative Pain|Patient Controlled Analgesia|Surgery|Nurse-Patient Relations
Interventions: DEVICE: Smith medical CADDsolis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Compare the Efficacy and Safety of Oral SHR 7280 Tablets With Ganirelix Acetate Injection in Infertile Female Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Infertile Female Subjects Undergoing Controlled Ovarian Hyperstimulation to Suppress Premature LH Surge and Prevent Early Ovulation
Interventions: DRUG: SHR7280；Ganirelix Acetate Injection simulant|DRUG: SHR7280 simulant； Ganirelix Acetate Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine and Valproic Acid in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia or Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|Recurrent Adult Acute Myeloid Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia|Untreated Adult Acute Myeloid Leukemia
Interventions: DRUG: decitabine|DRUG: valproic acid|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: L-ornithine L-aspartate in Overt Hepatic Encephalopathy
Status: COMPLETED
Conditions: Cirrhosis of Liver|Hepatic Encephalopathy
Interventions: DRUG: L-ornithine L-aspartate|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Training on Lower Extremity in Post-operative Anterior Cruciate Ligament Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Interventions: OTHER: Neuromuscular Training|OTHER: Strength Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart and BIAsp 30 in Subjects With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: insulin degludec/insulin aspart|DRUG: biphasic insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer
Status: WITHDRAWN
Conditions: Cachexia|Lymphoma|Melanoma (Skin)|Ovarian Cancer|Pain|Sarcoma|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: celecoxib|PROCEDURE: anticachectic therapy|PROCEDURE: nutritional support|PROCEDURE: pain therapy|PROCEDURE: supportive care/therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: EFFECT OF VIRTUAL REALITY BASED EXERCISE REGIME ON POSTURAL STABILITY AND GAIT DYNAMICS
Status: UNKNOWN
Conditions: Fall
Interventions: OTHER: Virtual Reality Training|OTHER: Moderate Aerobic Exercise Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: CG400549 Single Ascending Dose Study
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CG400549/placebo|DRUG: CG400549/placebo|DRUG: CG400549
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combined Treatment of Nightmares With Targeted Memory Reactivation and Imagery Rehearsal Therapy
Status: COMPLETED
Conditions: Nightmares, REM-Sleep Type
Interventions: BEHAVIORAL: Imagery Rehearsal Therapy and Targeted memory reactivation during REM sleep|BEHAVIORAL: Imagery Rehearsal Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Rhythmic Light Therapy for Alzheimer's Disease Patients
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: DEVICE: Tailored Rhythmic Lighting Intervention|DEVICE: Placebo Rhythmic Lighting Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT