pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Improving Sleep Continuity Through Mindfulness Training for Better Cognitive Ageing.
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Cognitive Aging
Interventions: BEHAVIORAL: Mindfulness Based Therapy for Insomnia|OTHER: Sleep Hygiene Education Exercise Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Structuring of Diabetes Care in Primary Health Care
Status: NOT_YET_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: OTHER: Redistribution of diabetes care between nurses and physicians|OTHER: Individualized glycemic target|OTHER: Minimum care recomendations|OTHER: No intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Simvastatin Effect on Portal Hypertension
Status: COMPLETED
Conditions: Portal Hypertension|Esophageal Varices|Liver Cirrhosis
Interventions: DRUG: Simvastatin|DRUG: Placebo pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postpartum Video Education
Status: COMPLETED
Conditions: Postpartum Hemorrhage|Postpartum Preeclampsia|Postpartum Sepsis|Postpartum Depression|Patient Empowerment|Patient Education|Postpartum Care
Interventions: OTHER: Video Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess Inflammation in Rheumatoid Arthritis Using Molecular Imaging Techniques
Status: TERMINATED
Conditions: Arthritis, Rheumatoid
Interventions: OTHER: Gadobutrol|OTHER: 18F-FDG|OTHER: 18F-GE-180
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Management of Ovarian Hyperstimulation Syndrome as a State of Defective Mineralocorticoid Response
Status: COMPLETED
Conditions: Ovarian Hyperstimulation Syndrome
Interventions: DRUG: Fludrocortisone 0.1 Milligrams (mg)|DRUG: Bromocriptine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Activation of A-delta-fibres and C-fibres in a First Degree Thermal Injury in Volunteers
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DEVICE: CO2-Laser stimulation (Laser Stimulation Device, SIFEC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults
Status: COMPLETED
Conditions: Aging|Alzheimer's Disease
Interventions: OTHER: Exercise Training|OTHER: Cognitive Training|OTHER: Flexibility Training|OTHER: Educational Sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy Male Subjects|Cardiovascular Disease
Interventions: DRUG: AZD5718 oral suspension crystalline form (1 to 100 mg/mL) (Part A)|DRUG: AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part A)|DRUG: AZD5718 placebo oral suspension|DRUG: AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Methotrexate, Vinblastine, Doxorubicin and Cisplatin (MVAC) Followed by Gemcitabine Plus Cisplatin (GEM+CDDP) in Locally Advanced or Metastatic Bladder Cancer
Status: TERMINATED
Conditions: Bladder Cancer
Interventions: DRUG: Methotrexate|DRUG: Vinblastine|DRUG: Doxorubicin|DRUG: Cisplatin|DRUG: Cisplatin|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy of GS-9131 Functional Monotherapy in Human Immunodeficiency Virus (HIV)-1-Infected Adults Failing a Nucleos(t)Ide Reverse Transcriptase Inhibitor-Containing Regimen With Nucleos(t)Ide Reverse Transcriptase Inhibitor Resistant Virus
Status: TERMINATED
Conditions: HIV-1-infection
Interventions: DRUG: GS-9131|DRUG: BIC|DRUG: TAF|DRUG: ARV regimen|DRUG: DRV|DRUG: RTV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conventional Prophylactic Oral Dexamethasone vs Short-course IV Dexamethasone in Paclitaxel Hypersensitivity
Status: RECRUITING
Conditions: Hypersensitivity Reactions
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Root Canal Disinfection: a Comparison Between Techniques
Status: UNKNOWN
Conditions: Endodontically Treated Teeth
Interventions: DEVICE: Root canal disinfection with XP-endo Finisher|DEVICE: Root canal disinfection with passive ultrasonic irrigation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Brain Glioblastoma|Adult Giant Cell Glioblastoma|Adult Gliosarcoma
Interventions: DRUG: Dimethyl Fumarate|DRUG: Temozolomide|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-invasive Brain Stimulation by Transcranial Pulse Stimulation as a Coadjunctive Treatment in Alzheimer's Disease
Status: UNKNOWN
Conditions: Alzheimer Disease
Interventions: OTHER: Transcranial pulse stimulation (TPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ENAC Blockade and Arterial Stiffness
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight and Obesity|Insulin Resistance
Interventions: DRUG: Placebo - Cap|DRUG: Amiloride Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Surgical Closure vs Anti-TNF in the Treatment of Perianal Fistulas in Crohn's Disease (PISA-II): a Comprehensive Cohort Design
Status: COMPLETED
Conditions: Perianal Fistula|Crohn Disease
Interventions: DRUG: anti-tumour necrosis factor α antibodies|PROCEDURE: Advancement plasty
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of High Sensitivity Cardiac Troponin In Ruling Out Emergency Patients With Acute Myocardial Injury and Infarction
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myocardial Infarction|Acute Coronary Syndrome
Interventions: DIAGNOSTIC_TEST: Cardiac Troponin Testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Noradrenergic Activity, Cognition and Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder|Early Life Trauma
Interventions: DRUG: yohimbine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Assessment of the Glyconutrient Ambrotose™ on Immunity, Gut Health, and Safety in Men and Women
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Ambrotose LIFE|DIETARY_SUPPLEMENT: Advanced Ambrotose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Obeticholic Acid in Bariatric and Gallstone Disease
Status: COMPLETED
Conditions: Obesity|Gallstones
Interventions: DRUG: Obeticholic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial Investigating the Pharmacokinetic (Mode of Action in the Body) and Safety Profiles of NN1250 (Insulin Degludec) in Subjects With Various Degrees of Impaired Liver Function and in Subjects With Normal Liver Function
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: insulin degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Soluble Beta-1,3/1,6-Glucan in Thermal Burns
Status: TERMINATED
Conditions: Burns
Interventions: DRUG: Soluble beta-1,3/1,6-glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the ReCor Medical Paradise System in Clinical Hypertension
Status: ACTIVE_NOT_RECRUITING
Conditions: Hypertension|Vascular Diseases
Interventions: DEVICE: The Paradise® Renal Denervation Ultrasound System|DEVICE: Sham Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Photobiomodulation Therapy in Aerobic Training and Detraining in Humans
Status: COMPLETED
Conditions: Aerobic Endurance
Interventions: DEVICE: PBMT|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study Effect of VIA-2291 on Vascular Inflammation
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: VIA-2291|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)
Status: COMPLETED
Conditions: Acute Coronary Syndrome|Non-ST-Elevation Myocardial Infarction|Unstable Angina
Interventions: PROCEDURE: Computed Tomographic Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Diagnostic Imaging of Myeloma Bone Lesions
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DIAGNOSTIC_TEST: FDG-PET-CT|DIAGNOSTIC_TEST: NaF-PET-CT|DIAGNOSTIC_TEST: Whole-body MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Paclitaxel and Cisplatin as First-Line Treatment for Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: cisplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity|Recurrent Verrucous Carcinoma of the Larynx|Recurrent Verrucous Carcinoma of the Oral Cavity|Salivary Gland Squamous Cell Carcinoma|Tongue Cancer
Interventions: DRUG: carboplatin|DRUG: paclitaxel albumin-stabilized nanoparticle formulation|DRUG: fluorouracil|DRUG: hydroxyurea|PROCEDURE: therapeutic conventional surgery|RADIATION: radiation therapy|RADIATION: hyperfractionated radiation therapy|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ultrasonography and Health Education Can Reduce the Unnecessary Caesarean Section in Bangladesh
Status: UNKNOWN
Conditions: Reduce Unnecessary Caesarean Section|Increase Institutional Delivery|Increase Antenatal Care
Interventions: DIAGNOSTIC_TEST: Ultrasonograpgy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD).
Status: COMPLETED
Conditions: Pediatric|Colon Capsule Endoscopy
Interventions: DEVICE: Second generation of colon capsule endoscopy (GIVEN IMAGING)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin
Status: RECRUITING
Conditions: Major Depressive Disorder|Depression|Treatment-Resistant Depression|Mood Disorders
Interventions: DRUG: Single Psychedelic Dose Psilocybin|DRUG: Two Psychedelic Doses Psilocybin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma|Lymphoma, Non-Hodgkin's
Interventions: DRUG: cemsidomide|DRUG: Dexamethasone Oral
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers
Status: RECRUITING
Conditions: Cervical Cancer|Throat Cancer|Oropharynx Cancer|Anal Cancer|Vulva Cancer|Vaginal Cancer|Penile Cancer|Metastatic Cancer|HPV-Related Malignancy|HPV-Related Carcinoma|HPV-Related Cervical Carcinoma|HPV-Related Squamous Cell Carcinoma|HPV-Related Adenocarcinoma|HPV Positive Oropharyngeal Squamous Cell Carcinoma|HPV-Associated Vaginal Adenocarcinoma|HPV-Related Adenosquamous Carcinoma|HPV-Related Endocervical Adenocarcinoma|HPV-Related Anal Squamous Cell Carcinoma|HPV-Related Penile Squamous Cell Carcinoma|HPV-Related Vulvar Squamous Cell Carcinoma|HPV Positive Rectal Squamous Cell Carcinoma
Interventions: BIOLOGICAL: E7 TCR-T cells|DRUG: Aldesleukin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating GDC-0980 Administered Once Weekly in Patients With Refractory Solid Tumors or Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Non-Hodgkin's Lymphoma, Solid Cancers
Interventions: DRUG: GDC-0980
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Caffeine in the Prevention of Post-operative Nausea and Vomiting
Status: COMPLETED
Conditions: Postoperative Nausea and Vomiting
Interventions: DRUG: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects
Status: COMPLETED
Conditions: Central Nervous System Tumors|Brain Tumors
Interventions: PROCEDURE: Radiation Therapy|PROCEDURE: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Cognitive Behaviour Therapy (CBT) With Metacognitive Therapy (MCT) in the Treatment of GAD
Status: COMPLETED
Conditions: Generalized Anxiety Disorder
Interventions: BEHAVIORAL: Cognitive-Behavioural Therapy|BEHAVIORAL: Meta-Cognitive Therapy|BEHAVIORAL: Waiting list
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia
Status: UNKNOWN
Conditions: Heroin Dependence|Amphetamine Dependence
Interventions: DRUG: Mirtazapine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes
Status: RECRUITING
Conditions: Preterm Premature Rupture of Membrane
Interventions: OTHER: Vaginal cleansing with chlorhexidine gluconate solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visceral Manifold Study for the Repair of Thoracoabdominal Aortic Aneurysms
Status: COMPLETED
Conditions: Thoracoabdominal Aortic Aneurysms
Interventions: DEVICE: Valiant™Thoracoabdominal Stent Graft System
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease
Interventions: BEHAVIORAL: Self-Guided Lifestyle Intervention|BEHAVIORAL: Structured Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Single Dose Study of DWP10292 in Healthy Male Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: DWP10292|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Transplant; Complications
Interventions: DRUG: Dexmedetomidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Evodial Hemodialyzer Selectivity Modifications (Evodial +)
Status: COMPLETED
Conditions: End Stage Renal Disease (ESRD)
Interventions: DEVICE: Evodial|DEVICE: Evodial+ Condition B1|DEVICE: Evodial+ Condition B2|DEVICE: Evodial+ Condition C
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Cardiovascular Magnetic Resonance Tissue Characterisation and Wearable Technology to PREDICT Clinical Outcomes, Response to Therapy and Arrhythmias in Hospitalised Heart Failure Patients
Status: UNKNOWN
Conditions: Heart Failure|Diffuse Fibrosis|Focal Fibrosis|Arrythmia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Ability of Octenilin® to Reduce Odour of Malodorous Wound
Status: COMPLETED
Conditions: Wound|Wound Heal
Interventions: OTHER: Use of Ocetnilin|OTHER: Use of NaCl 0.9%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Colesevelam in Fecal Incontinence
Status: COMPLETED
Conditions: Fecal Incontinence|Bile Acid Malabsorption
Interventions: DRUG: Colesevelam|DRUG: Clonidine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV
Status: TERMINATED
Conditions: HIV Infection|Tuberculosis
Interventions: DRUG: Standard-dose Lopinavir/Ritonavir|DRUG: Double-dose Lopinavir/Ritonavir|DRUG: Raltegravir|DRUG: Isoniazid|DRUG: Pyridoxine|DRUG: Pyrazinamide|DRUG: Ethambutol|DRUG: Rifabutin|DRUG: Rifampin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Status: COMPLETED
Conditions: Adenovirus|Anesthesia|Anxiety|Anxiolysis|Autism|Autistic Disorder|Bacterial Meningitis|Bacterial Septicemia|Benzodiazepine|Bipolar Disorder|Bone and Joint Infections|Central Nervous System Infections|Convulsions|Cytomegalovirus Retinitis|Early-onset Schizophrenia Spectrum Disorders|Epilepsy|General Anesthesia|Gynecologic Infections|Herpes Simplex Virus|Infantile Hemangioma|Infection|Inflammation|Inflammatory Conditions|Intra-abdominal Infections|Lower Respiratory Tract Infections|Migraines|Pain|Pneumonia|Schizophrenia|Sedation|Seizures|Skeletal Muscle Spasms|Skin and Skin-structure Infections|Treatment-resistant Schizophrenia|Urinary Tract Infections|Withdrawal|Sepsis|Gram-negative Infection|Bradycardia|Cardiac Arrest|Cardiac Arrhythmia|Staphylococcal Infections|Nosocomial Pneumonia|Neuromuscular Blockade|Methicillin Resistant Staphylococcus Aureus|Endocarditis|Neutropenia|Headache|Fibrinolytic Bleeding|Pulmonary Arterial Hypertension|CMV Retinitis|Hypertension|Chronic Kidney Diseases|Hyperaldosteronism|Hypokalemia|Heart Failure|Hemophilia|Heavy Menstrual Bleeding|Insomnia
Interventions: DRUG: The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression
Status: COMPLETED
Conditions: Postpartum Depression
Interventions: DRUG: SAGE-217 15/20 mg Oral Solution|DRUG: Placebo|DRUG: SAGE 217 30 mg Capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adjuvant Chemoradiotherapy and Interferon Alfa in Treating Patients With Resected Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: BIOLOGICAL: interferon-alfa-2b|DRUG: cisplatin|DRUG: 5-fluorouracil|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing the Addition of Immunotherapy With Hu5F9-G4 (Magrolimab) to the Usual PARP Inhibitor, Olaparib for Treatment of Metastatic or Recurrent Breast or Castrate-Resistant Prostate Cancer With BRCA Mutations
Status: WITHDRAWN
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Castration-Resistant Prostate Carcinoma|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|BIOLOGICAL: Magrolimab|DRUG: Olaparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Immediate Implant Stability When Adding Mixture of Hyaluronic Acid and Melatonin
Status: UNKNOWN
Conditions: Immediate Dental Implant
Interventions: PROCEDURE: Immediate implant placement|DRUG: Hyaluronic acid and Melatonin Mixture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Osteopathic Manipulative Treatment for Recurrent Mastitis
Status: WITHDRAWN
Conditions: Mastitis
Interventions: PROCEDURE: Osteopathic Manipulative Treatment (OMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Postoperative Analgesia in Laparoscopic Abdominal Surgery After Exparel Via TAP or Local Infiltration
Status: UNKNOWN
Conditions: Pain, Postoperative|Anesthesia, Local|Anesthesia; Functional|Anesthesia|Opioid Use
Interventions: DRUG: Exparel 266 MG Per 20 ML Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Disinfection Effect of Gaseous Ozone
Status: COMPLETED
Conditions: Endodontic Treatment
Interventions: PROCEDURE: 2.5% NaOCl group: The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies.|PROCEDURE: 0.9% sterile saline solution combined with 80 seconds: The OzonyTronX® interventions performed in the study are root- canal therapies and disinfection procedure of these therapies.|PROCEDURE: 2.5% NaOCl with 80 seconds OzonyTronX®:The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia
Status: UNKNOWN
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: cytarabine|DRUG: etoposide|DRUG: idarubicin|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: SIMPADICO - Study of Immune Modulation Therapy in Peripheral Arterial Disease and Intermittent Claudication Outcomes
Status: TERMINATED
Conditions: Peripheral Arterial Disease|Arterial Occlusive Diseases|Intermittent Claudication
Interventions: DEVICE: Celacade™ system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Mechanism of Dipyridamole Action in Platelets: in Vivo Study With Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Aggrenox|DRUG: Persantin Retard|DRUG: Acetylsalicylic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Safety and Immunogenicity of HEPLISAV-B® to Engerix-B® in Chronic Kidney Disease (CKD) Patients
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: BIOLOGICAL: HEPLISAV-B|BIOLOGICAL: Engerix-B|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Two-arm, Non-interventional Study of JAKAVI® (Ruxolitinib) in Patients With Myelofibrosis
Status: COMPLETED
Conditions: Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis
Interventions: OTHER: Jakavi
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study Of PF-00562271, Including Patients With Pancreatic, Head And Neck, Prostatic Neoplasms
Status: COMPLETED
Conditions: Head and Neck Neoplasm|Prostatic Neoplasm|Pancreatic Neoplasm
Interventions: DRUG: PF00562271|DRUG: PF00562271|DRUG: PF00562271|DRUG: PF00562271
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Intrathecal Morphine on Sleep Apnea Syndrome
Status: COMPLETED
Conditions: Sleep Apnea Syndromes
Interventions: DRUG: Bupivacaine with normal saline|DRUG: Bupivacaine with intrathecal morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Health Education Using Text Messaging Prevents Hypertension in High Risk People
Status: UNKNOWN
Conditions: Hypertension|Cardiovascular Diseases
Interventions: BEHAVIORAL: mobile text messages|BEHAVIORAL: virtual community|BEHAVIORAL: brochures|OTHER: Usual care|DEVICE: mobile phone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: CPAP on Oxygenation and Pulmonary Function in Elderly Patients After Major Open Abdominal Surgery
Status: COMPLETED
Conditions: Continuous Positive Airway Pressure|Pulmonary Function|Older People
Interventions: DEVICE: Auto CPAP via nasal mask (JPAP machine)|DEVICE: Constant CPAP via facial mask (O2-Max Trio system)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Efficacy of FK506E (MR4) in Patients Undergoing Primary Liver Transplantation.
Status: COMPLETED
Conditions: Liver Transplantation
Interventions: DRUG: tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Thermic Effect of Three Different Meals in Healthy Women
Status: COMPLETED
Conditions: Weight Loss|Obesity
Interventions: OTHER: Whole Food Meal|OTHER: Processed Food Meal|OTHER: Gluten-free and lactose-free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Endostar Combined With MPFC Adjuvant Treatment of Esophageal Cancer Clinical Trial
Status: TERMINATED
Conditions: Esophageal
Interventions: DRUG: "Endostar"|DRUG: Liposo|DRUG: cisplatin|DRUG: Gimeracil and Oteracil Potassium （Tegafur）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Dormant Perimenopausal Ovarian Follicles Become FSH Responsive?
Status: UNKNOWN
Conditions: Low Ovarian Reserve|Poor Responders to Gonadotropihins Treatment
Interventions: OTHER: Removal of half an ovary
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10
Status: COMPLETED
Conditions: Ketamine-Induced Neurotoxicity
Interventions: DRUG: ACTH4-10Pro8-Gly9-Pro10|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition
Status: ENROLLING_BY_INVITATION
Conditions: Genetic Predisposition to Disease|Breast Cancer Female|Ovarian Cancer|Hereditary Breast and Ovarian Cancer|Hereditary Cancer Syndrome|Hereditary Diseases|Gene Mutation-Related Cancer
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Co Morbid Attention Deficit and Hyperactivity Disorder(ADHD) and Developmental Co Ordination Disorder (DCD)
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity|Developmental Coordination Disorder
Interventions: DRUG: Neurostimulant pharmaceutical drugs
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fuzheng Huayu Tablets Against Posthepatitic Cirrhosis
Status: COMPLETED
Conditions: Posthepatitic Cirrhosis
Interventions: DRUG: Fuzheng Huayu Tablets|DRUG: sham Fuzheng Huayu Tablets (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Haemadsorption in Major Burns
Status: UNKNOWN
Conditions: Burns|Multiple Organ Failure|Shock|Organ Dysfunction Syndrome, Multiple|Renal Dysfunction|Cytokine Storm
Interventions: DEVICE: CytoSorb haemadsorption device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous CAR-T/TCR-T Cell Immunotherapy for Solid Malignancies
Status: UNKNOWN
Conditions: Esophagus Cancer|Hepatoma|Glioma|Gastric Cancer
Interventions: BIOLOGICAL: CAR-T/TCR-T cells immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Tislelizumab|RADIATION: Low-dose radiotherapy|DRUG: Nab-paclitaxel|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Corrective Exercises With Neuromuscular Electrical Stimulation In Children With Flexible Flatfeet
Status: COMPLETED
Conditions: Sports Physical Therapy
Interventions: OTHER: Corrective exercises|OTHER: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Pre-Meal Whey Protein Microgels Administration on Post-Prandial Glycemic Response.
Status: COMPLETED
Conditions: Dietary Supplement
Interventions: DIETARY_SUPPLEMENT: Whey Protein Micro Gel|OTHER: Water without Whey Protein.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: SHR-4602 for Injection in Subjects With HER2-expressing or -Mutated Unresectable or Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: HER2-expressing or -Mutated Unresectable or Metastatic Solid Tumors
Interventions: DRUG: SHR-4602
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate A Clostridium Difficile Vaccine In Healthy Adults Aged 50 To 85 Years, Who Will Each Receive 3 Doses Of Vaccine.
Status: COMPLETED
Conditions: Clostridium Difficile
Interventions: BIOLOGICAL: C. difficile vaccine with adjuvant|BIOLOGICAL: Placebo|BIOLOGICAL: C. difficile vaccine with adjuvant|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluating Additional Platelet Inhibition in Patients With High Platelet Reactivity Undergoing Percutaneous Coronary Intervention
Status: TERMINATED
Conditions: Cardiovascular Disease|Acute Coronary Syndrome
Interventions: DRUG: Prasugrel|DRUG: Plavix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of Genz-682452 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: Genz-682452|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Novolog vs. Fiasp Insulin in Non-critically Ill Hospitalized Patients With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 2 Diabetes Treated With Insulin
Interventions: DRUG: Insulin glargine|DRUG: NovoLog|DRUG: Insulin Fiasp|OTHER: Standard carbohydrate diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Demonstrate Pharmacokinetic and Pharmacodynamic Similarity Between NKF-INS(A), US-NovoLog®, and EU-NovoRapid®
Status: RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: NKF-INS(A)|DRUG: EU-NovoRapid®|DRUG: US-NovoLog®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Comparison of Centurion® Vision System With Balanced Tip and the Infiniti® Vision System With the Mini Flared Kelman (MFK) Tip During Cataract Extraction Surgery of Hard Lenses
Status: COMPLETED
Conditions: Cataracts
Interventions: DEVICE: Centurion® Vision System, 45° Balanced Tip|DEVICE: Centurion® Vision System, 45° MFK Tip|DEVICE: lnfiniti® Vision System, 45° MFK Tip|DEVICE: INTREPID® Ultra infusion sleeve|DEVICE: Ultra infusion sleeve
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of The Second-line Treatment of Advanced Gastric / Gastroesophageal Junction Adenocarcinoma With Cadonilimab and Fruquintinib Combined With Paclitaxel-albumin
Status: RECRUITING
Conditions: Gastric / Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Cadonilimab and Fruquintinib Combined With Paclitaxel-albumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Abaloparatide on Lumbar Disc Degeneration
Status: WITHDRAWN
Conditions: Degeneration Disc Intervertebral
Interventions: DRUG: Abaloparatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: HIV/STI Risk Reduction for Incarcerated Women With Interpersonal Violence
Status: COMPLETED
Conditions: Unsafe Sex|Physical Violence|Sexual Assault|Sexual Abuse
Interventions: BEHAVIORAL: Nutrition Program (NP)|BEHAVIORAL: Women's Prison CoOp (WPC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Saffron Extract Supplementation on Emotional Well-being Alterations
Status: RECRUITING
Conditions: Mood Disturbance
Interventions: DIETARY_SUPPLEMENT: Saffron extract|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Research Into Antipsychotic Discontinuation and Reduction Trial
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Delusional Disorder|Schizophreniform Disorders
Interventions: DRUG: Antipsychotic Reduction|DRUG: Antipsychotic Maintenance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Pharmacokinetic Interaction Between Kaletra® (LPV/r) and BILR 355 BS Plus Ritonavir in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BILR 355 BS|DRUG: Ritonavir (RTV)|DRUG: Kaletra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Nivolumab in Participants With Locally Advanced or Metastatic (Stage IIIB-IV) Non-Small Cell Lung Cancer (NSCLC) With Squamous and Non-Squamous Histology After Prior Chemotherapy Treated in Real World Settings in Greece and Cyprus
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-Small Cell Lung Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Forecasting and Preventing Post-Bariatric Hypoglycaemia WP 3
Status: COMPLETED
Conditions: Post-bariatric Hypoglycaemia|Roux-en-Y Gastric Bypass
Interventions: OTHER: Timing of preventive action based on prediction model|OTHER: Hypoglycaemia treatment at hypoglycaemia (usual care)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cerebral Oximetry to Reduce Organ Dysfunction After Non-cardiac Surgery
Status: UNKNOWN
Conditions: Cerebral Desaturation|Surgery
Interventions: DEVICE: Bilateral NIRS (Masimo, O3TM Regional Oximetry)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pressure Analysis of Trendelenburg Position Effect on Indices From Arterial Pressure
Status: RECRUITING
Conditions: Anesthesia|Fluid and Electrolyte Imbalance|Hemodynamic Instability
Interventions: DEVICE: HemoSphere advanced monitoring platform with Acumen Hypotension Prediction Index Software
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of Skin Cleansers and Skin Protectants in Management of Incontinence-associated Dermatitis
Status: TERMINATED
Conditions: Incontinence-associated Dermatitis
Interventions: DEVICE: 3M Cavilon No-Rinse Skin Cleanser and 3M Cavilon Advanced Skin Protectant|DEVICE: Conveen EasiCleanse and Conveen Critic Barrier|DEVICE: Standard cleansing and Conveen Critic Barrier
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
Status: UNKNOWN
Conditions: Portal Vein, Cavernous Transformation of|Portal Vein Thrombosis|Liver Cirrhosis|Bleeding Esophageal Varices
Interventions: PROCEDURE: TIPS|DRUG: Propranolol|PROCEDURE: Endoscopic therapy|DRUG: Warfarin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety, Tolerability Pharmacokinetics, and Pharmacodynamics of a New Spray Dried Dispersion (SDD) Formulation of CC-11050 After Single Dose of CC-11050 and to Evaluate the Pharmacokinetics of CC-11050 Under Fasted and Fed Conditions and After Coadministration With Omeprazole
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CC-11050
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Lifestyle Interventions to Treat Elevated Cardiometabolic Risk in Primary Care
Status: COMPLETED
Conditions: Obesity|Pre-diabetes|Metabolic Syndrome
Interventions: BEHAVIORAL: Self-management program (SM)|BEHAVIORAL: Care management program (CM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study
Status: WITHDRAWN
Conditions: Idiopathic Pulmonary Fibrosis|Hypersensitivity Pneumonitis
Interventions: DRUG: Hyperpolarized Xe129
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Chiropractic and Acupressure for Headaches
Status: UNKNOWN
Conditions: Cervicogenic Headache|Tension-type Headache|Migraine Headache
Interventions: OTHER: chiropractic treatment|DEVICE: Dr. Zaxx pillow
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Dose Ranging Study of Insulin Receptor MAb-IDUA Fusion Protein in Patients With MPS I
Status: COMPLETED
Conditions: Mucopolysaccharidosis I
Interventions: DRUG: AGT-181 (HIRMAb-IDUA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Effectiveness and Safety of Paliperidone ER (Extended-release) Compared With Quetiapine in Patients With Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: paliperidone ER tablets, quetiapine tablets, placebo - all over encapsulated
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic Pain
Status: COMPLETED
Conditions: Opioid Dependence|Chronic Pain
Interventions: OTHER: Enhanced Opioid Stewardship Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Randomised Study of Azacitidine Versus Azacitidine With Vorinostat in Patients With AML or High Risk MDS
Status: COMPLETED
Conditions: Leukemia, Myeloid, Acute
Interventions: DRUG: Azacitidine|DRUG: Vorinostat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intermittent Theta Burst Stimulation on Anhedonia in Depression
Status: COMPLETED
Conditions: Depression|Electroencephalography|Transcranial Magnetic Stimulation
Interventions: DEVICE: repeated transcranial magnetic stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transcranial Alternating Current Stimulation for Patients With Mild Alzheimer's Disease (TRANSFORM-AD)
Status: COMPLETED
Conditions: Alzheimer Disease
Interventions: DEVICE: transcranial alternating current stimulation|DEVICE: sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clofarabine and Non-Myeloablative Allogeneic Hematopoietic Transplantation
Status: TERMINATED
Conditions: Leukemia|Myelodysplastic Syndrome|Chronic Myelogenous Leukemia|Lymphoma|Hodgkin's Lymphoma|Multiple Myeloma
Interventions: DRUG: Clofar, Cyclophos, Alemtuzumab|DRUG: Clofar, Cyclophos,Alemtuzumab(Ph II)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT