pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Study of Clofarabine & Cytosine Arabinoside Therapy for Older Adults With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: clofarabine|DRUG: Ara-C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Bosutinib on Safety, Tolerability, Biomarkers and Clinical Outcomes in Dementia With Lewy Bodies
Status: COMPLETED
Conditions: Dementia With Lewy Bodies
Interventions: DRUG: Placebo Oral Tablet|DRUG: Bosutinib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Assessing RLT Using [177Lu]Lu-PentixaTher for Relapsed/Refractory CXCR4+ Acute Leukemia.
Status: NOT_YET_RECRUITING
Conditions: Acute Leukemia
Interventions: DRUG: Experimental drug [177Lu]Lu-PentixaTher
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of a Nasal Spray Containing Iota-Carrageenan in the Prophylaxis of COVID-19 Disease in Health Personnel Dedicated to Patients Care With COVID-19 Disease
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Iota-Carrageenan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: OZOCLO_MUCOSITIS: a New Protocol for Prevention of Oral Mucositis
Status: UNKNOWN
Conditions: Mucositis (MeSH Unique ID: D052016)|Stomatitis (MeSH Unique ID: D013280)
Interventions: DRUG: 1. alpha acid lipoic - tables|DRUG: 2. ozonated oil - mouthwash|DRUG: 3. chlorhexidine 0,2% - mouthwash|DRUG: 4. sodium bicarbonate 5% solution - mouthwash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Recurrent Colon Cancer|Recurrent Rectal Cancer|Stage IV Colon Cancer|Stage IV Rectal Cancer
Interventions: DRUG: irinotecan hydrochloride|DRUG: leucovorin calcium|DRUG: fluorouracil|BIOLOGICAL: bevacizumab|RADIATION: yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Initial and Chronic Methicillin Resistant Staphylococcus Aureus (MRSA) Infection in Cystic Fibrosis (CF)
Status: COMPLETED
Conditions: Methicillin-Resistant Staphylococcus Aureus|Cystic Fibrosis
Interventions: OTHER: Intervention N/A. Observational study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of SEROQUEL Extended Release (XR) in Acute Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Quetiapine XR (Seroquel XR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
Status: RECRUITING
Conditions: Keratoconus|Ectasia|Crosslinking|Fuchs' Endothelial Dystrophy
Interventions: PROCEDURE: Brillouin imaging
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: TAC Versus TCX as Adjuvant Treatment for Node-Positive Her2-Negative Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Docetaxel, Doxorubicin, Cyclophosphamide|DRUG: Docetaxel, Cyclophosphamide, Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bemarituzumab (FPA144) Combined With Modified FOLFOX6 (mFOLFOX6) in Gastric/Gastroesophageal Junction Cancer
Status: COMPLETED
Conditions: Gastric Cancer
Interventions: BIOLOGICAL: Bemarituzumab|DRUG: Placebo|DRUG: Modified FOLFOX6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Children
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of QT and QTc Intervals in Patients Administered Extended Release Paliperidone or Quetiapine
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: Paliperidone ER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Study of Ustekinumab in Participants With Active Systemic Lupus Erythematosus
Status: TERMINATED
Conditions: Lupus Erythematosus, Systemic
Interventions: DRUG: Placebo|DRUG: Ustekinumab (approximately 6 mg/kg)|DRUG: Ustekinumab 90 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Palifermin for the Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer
Status: COMPLETED
Conditions: Colon Cancer
Interventions: DRUG: palifermin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Esmolol Administration on Postoperative Recovery
Status: RECRUITING
Conditions: Pain, Acute|Pain, Postoperative|Pain, Chronic Post-Surgical|Esmolol|Inguinal Hernia Repair|Analgesia|Nociceptive Pain
Interventions: DRUG: Esmolol Hydrochloride|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Status: RECRUITING
Conditions: Lower Respiratory Tract Infection|Parainfluenza|Immunocompromised|COVID-19
Interventions: DRUG: DAS181|DRUG: Placebo|DRUG: DAS181 COVID-19|DRUG: DAS181 OL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Advance Targeted Transfusion in Anemic Cardiac Surgical Patients for Kidney Protection: A Proof of Concept Pilot Study
Status: COMPLETED
Conditions: Kidney Injury
Interventions: OTHER: Advanced red blood cell transfusion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ROPE Registry Project to Determine the Safety and Efficacy of Prostate Artery Embolisation (PAE) for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Enlargement (LUTS BPE).
Status: UNKNOWN
Conditions: Lower Urinary Tract Symptoms Caused by Benign Prostatic Enlargement (LUTS BPE)|Prostate Artery Embolisation (PAE)|Transurethral Resection of the Prostate (TURP)|Open Prostatectomy|Laser Enucleation or Ablation of the Prostate
Interventions: PROCEDURE: Prostatic Artery Embolisation|PROCEDURE: TURP|PROCEDURE: Open prostatectomy|PROCEDURE: Laser prostate surgery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer
Status: RECRUITING
Conditions: Brain Metastases|HER2-positive Breast Cancer
Interventions: COMBINATION_PRODUCT: Combined use of SRS with Tucatinib, Trastuzumab, and Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electronic Xoft Intersociety Brachytherapy Trial: Electronic Brachytherapy (EBT) For Treatment of Early Stage Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Carcinoma|Lumpectomy|Ductal Carcinoma in Situ
Interventions: RADIATION: Electronic Brachytherapy|RADIATION: Intracavitary accelerated partial breast irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison Between Local Radiotherapy Alone or Combined With Obinutuzumab in Early Stage Follicular Lymphoma: the GAZEBO Trial From the Fondazione Italiana Linfomi
Status: RECRUITING
Conditions: Follicular Lymphoma
Interventions: RADIATION: Radiotherapy|OTHER: Radiotherapy plus Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: MDD
Interventions: DEVICE: Relivion®DP- Active|DEVICE: Relivion®DP- Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PROstate Cancer TReatment Optimization Via Analysis of Circulating Tumour DNA
Status: RECRUITING
Conditions: Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Interventions: DRUG: Enzalutamide|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
Status: NOT_YET_RECRUITING
Conditions: PTSD|Alcohol; Use, Problem
Interventions: BEHAVIORAL: Seeking Safety + Signs of Safety toolkit|BEHAVIORAL: Treatment as usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BP as a Super-light Mesh and as a New Fixation Device for General Surgery -DM108/2008-B
Status: UNKNOWN
Conditions: Hernia
Interventions: DEVICE: BP self-standing felt device|DEVICE: PR Parietene mesh device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominal Versus Vaginal Bisection in Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Hysterectomy|Laparoscopy|Uterine Bisection|Large Uteri
Interventions: PROCEDURE: Vaginal bisection|PROCEDURE: Abdominal bisection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of the Sonablate® 500 to Treat Localized (T1c/T2a) Prostate Cancer
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: DEVICE: HIFU (Sonablate® 500)|DEVICE: Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Active Telephone Calls in the Compliance of Hypertensive Patients With Treatment
Status: UNKNOWN
Conditions: Blood Pressure
Interventions: BEHAVIORAL: phone call|DRUG: amlodipine (calcium chanel blocker) and losartan (at1 antagonist)|DRUG: atenolol (beta blocker) and hydrochlorothiazide (diuretic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 3)
Status: COMPLETED
Conditions: Raynaud's Phenomenon Secondary to Systemic Sclerosis
Interventions: DRUG: Placebo IV infusion|DRUG: Iloprost Injection, for intravenous use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoproliferative Disorder|HHV-8|Malignancy|HIV
Interventions: DRUG: Etoposide|DRUG: Interferon-alpha|DRUG: Rituximab|DRUG: Zidovudine|DRUG: Liposomal Doxorubicin|DRUG: Bortezomib|DRUG: Valganciclovir|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Cyclophosphamide|DRUG: Filgrastim (G-CSF)|DRUG: Prednisone|DRUG: Sirolimus|OTHER: Observation Only
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Exploratory Efficacy Parameters of AIR DNase™in Patients With Cystic Fibrosis Previously Treated With Pulmozyme®
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: DRUG: AIR DNase™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effect of Copenhagen Adduction Exercises Performed at Different Load-intensity
Status: RECRUITING
Conditions: Groin Injury
Interventions: OTHER: High-intensity Copenhagen adduction exercise|OTHER: Low-intensity Copenhagen adduction exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome
Status: RECRUITING
Conditions: Gorlin Syndrome
Interventions: DRUG: Patidegib Topical Gel|DRUG: Patidegib Topical Gel with no active patidegib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness if Premedication With Single Dose Piroxicam and Prednisolone After a Single Visit Root Canal Treatment .
Status: COMPLETED
Conditions: Post-operative Endodontic Pain
Interventions: DRUG: Piroxicam 20 mg|DRUG: prednisolone 20 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gemtuzumab Ozogamicin With or Without Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: etoposide|DRUG: gemtuzumab ozogamicin|DRUG: idarubicin|DRUG: mitoxantrone hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial in Adults With Non-Hodgkin Lymphoma (NHL), With a Particular Emphasis on Cutaneous T Cell Lymphoma (CTCL), Testing the Safety and Activity of a Novel Drug to Inhibit a Protein Called Tumor Necrosis Factor Receptor 2 That Drives Both Lymphoma Growth and Escape of the Immune System
Status: NOT_YET_RECRUITING
Conditions: NHL|Cutaneous T Cell Lymphoma|Peripheral T-cell Lymphoma
Interventions: BIOLOGICAL: BITR2101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DaxibotulinumtoxinA for Injection to Treat Moderate to Severe Glabellar Lines
Status: COMPLETED
Conditions: Glabellar Frown Lines
Interventions: BIOLOGICAL: Botulinum Toxins, Type A|BIOLOGICAL: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Exercise Training on Balance, Walking Capacity, and Quality of Life in Sub-acute Stroke.
Status: COMPLETED
Conditions: Cerebrovascular Stroke|Cerebrovascular Accident, Acute|Cerebral Stroke
Interventions: OTHER: Combined Therapy (Aerobic Exercise in addition to conventional therapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Hydroxy-apatite Coated Hip Stems
Status: COMPLETED
Conditions: Hip Osteoarthritis
Interventions: DEVICE: Avenir cementless hip stem|DEVICE: Corail HA-coated hip stem
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Assessment of the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer Metastatic|BRCA 1 Gene Mutation|BRCA 2 Gene Mutation
Interventions: DRUG: Olaparib|DRUG: Physician's choice chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: LAM561 With RT and TMZ for Adults With Glioblastoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Glioblastoma|Glioblastoma Multiforme
Interventions: DRUG: LAM561|DRUG: TMZ|RADIATION: RT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Intermittent Explosive Disorder
Status: TERMINATED
Conditions: Intermittent Explosive Disorder
Interventions: DRUG: AVP-786|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Randomized Control Trial of Intraperitoneal Bupivacaine During Cholecystectomy
Status: COMPLETED
Conditions: Cholecystitis|Gall Stone Pancreatitis
Interventions: DRUG: Bupivacaine|OTHER: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Does Flushing the Uterine Cavity With Follicular Fluid After Ovum Pick-up Improve Implantation Rates in ICSI Cycles?
Status: COMPLETED
Conditions: Intra-cytoplasmic Sperm Injection Outcome
Interventions: BIOLOGICAL: Follicular fluid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Overweight and Obesity
Interventions: BEHAVIORAL: Hypocaloric, low carbohydrate diet|BEHAVIORAL: Hypocaloric, moderate low fat diet|BEHAVIORAL: Mediterranean diet, no caloric restriction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerobic Interval Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypoxemia
Status: COMPLETED
Conditions: Pulmonary Disease, Chronic Obstructive|Hypertension, Pulmonary|Hypoxia
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer
Status: COMPLETED
Conditions: Early Stage Breast Cancer
Interventions: DRUG: Melatonin|DRUG: Vitamin D|DRUG: Placebo (melatonin)|DRUG: Placebo (vitamin D)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Total Occlusive Ionic Silver-containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection
Status: COMPLETED
Conditions: Incisional Surgical Site Infections
Interventions: PROCEDURE: ionic silver-containing dressing|PROCEDURE: Mupirocin ointment application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Midodrine, Octreotide and Albumin: Impact on Renal Function of Patients With Liver Cirrhosis and Renal Failure
Status: WITHDRAWN
Conditions: Fibrosis|Renal Failure|Hepatorenal Syndrome
Interventions: DRUG: Albumin|DRUG: Midodrine|DRUG: Octreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility, Efficacy, and Safety of Venous Ulcer Treatment Using a Hand Plasma Generator (PlasmaDerm) Chronisch venöser Ulzerationen (PlasmaDerm)
Status: COMPLETED
Conditions: Venous Insufficiency
Interventions: DEVICE: PlasmaDerm|PROCEDURE: standard care of Ulcera crurum
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Intervention for Rural Women at High Risk for HIV/HCV
Status: COMPLETED
Conditions: Acquired Immune Deficiency Syndrome Virus|Hepatitis C|Drug Abuse
Interventions: OTHER: MI-based HIV Risk Reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Fulvestrant With or Without Anastrozole or Exemestane Alone in Treating Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: anastrozole|DRUG: exemestane|DRUG: fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vasopressin in Traumatic Hemorrhagic Shock Study
Status: COMPLETED
Conditions: Shock|Hypovolemia|Hemorrhagic Shock
Interventions: DRUG: Vasopressin|DRUG: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease
Status: NOT_YET_RECRUITING
Conditions: Periodontitis, Adult|Smoking|Periodontal Diseases
Interventions: DIAGNOSTIC_TEST: Clinical Measurements and Saliva Sample Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Maternal Antiviral Prophylaxis to Prevent Perinatal Transmission of Hepatitis B Virus in Thailand
Status: COMPLETED
Conditions: Hepatitis B Chronic Infection|Pregnancy
Interventions: DRUG: tenofovir disoproxil fumarate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase II Trial of PF-00299804 in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of Esophagus
Status: COMPLETED
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: PF804
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Robotic Hand Rehabilitation
Status: NOT_YET_RECRUITING
Conditions: Stroke|Spasticity as Sequela of Stroke|Upper Limb
Interventions: DEVICE: Technological Group|OTHER: Conventional Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
Status: COMPLETED
Conditions: Crohn's Disease|Ulcerative Colitis|Rectal Cancer|Colon Cancer|Colon Polyps|Rectal Polyps|Diverticulitis
Interventions: DRUG: Hextend|DRUG: Lactated Ringers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Methadone|DRUG: Morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Social Media-based Electronic Bibliotherapy for Dementia Caregivers
Status: COMPLETED
Conditions: Mental Health|Quality of Life|Dementia Caregivers
Interventions: OTHER: Social media-based electronic bibliotherapy|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Visual Function After Implantation of Bilateral AcrySoft ReSTOR Aspheric IOL
Status: COMPLETED
Conditions: Cataract
Interventions: DEVICE: AcrySof® ReSTOR® Aspheric IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety of FMT: OpenBiome Outcomes and Longitudinal Follow-up (STOOL) for Recurrent Clostridium Difficile Infection
Status: TERMINATED
Conditions: Clostridium Difficile
Interventions: DRUG: Fecal Microbiota Preparation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Reversed Tracking Method for Identification of EBSLN in Thyroid Surgery
Status: UNKNOWN
Conditions: Thyroid Cancer|Recurrent Laryngeal Nerve Injuries
Interventions: PROCEDURE: Reversed Tracking Method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: AIH-induced Walking Recovery After Subacute SCI
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injury
Interventions: OTHER: Daily acute intermittent hypoxia (dAIH)|OTHER: dSHAM|OTHER: Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Imatinib in Acute Ischaemic Stroke
Status: UNKNOWN
Conditions: Acute Ischaemic Stroke
Interventions: DRUG: Imatinib 400mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Maternal Iron Deficiency Anemia on Fetal Hemodynamic and Neonatal Outcome
Status: UNKNOWN
Conditions: Fetal Conditions
Interventions: OTHER: Oral ferrous fumerate for Group A, Parenteral iron sucrose for Group B, Compatible blood transfusion for Group C
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Efficacy Study of BCD-022 With Paclitaxel Compared to Herceptin With Paclitaxel in HER2+ Metastatic Breast Cancer Patients
Status: COMPLETED
Conditions: Human Epithelial Receptor (HER)-2 Positive Breast Cancer
Interventions: DRUG: Trastuzumab|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Whole Blood Metal Ion Concentrations in Metal-on-metal Total Hip Arthroplasty and Hip Resurfacing
Status: TERMINATED
Conditions: Osteoarthritis, Hip
Interventions: DEVICE: Magnum, Zimmer Biomet, Warsaw, IN|DEVICE: Recap, Zimmer Biomet, Warsaw, IN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Moderate Physical Activity in Helping Patients Recover Physically and Emotionally From Stage II Or Stage III Colorectal Cancer
Status: COMPLETED
Conditions: Anxiety Disorder|Colorectal Cancer|Depression|Psychosocial Effects of Cancer and Its Treatment
Interventions: BEHAVIORAL: exercise intervention|OTHER: flow cytometry|OTHER: laboratory biomarker analysis|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Mobile Phone Self-Monitoring Tool to Increase Emotional Self-Awareness and Reduce Depression in Young People
Status: COMPLETED
Conditions: Depression
Interventions: DEVICE: Mobile Tracking Young People's Experiences (mobiletype)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Clinical Center Reference Endotoxin (CCRE)|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: MRG-001 in Patients With Alcoholic Hepatitis
Status: NOT_YET_RECRUITING
Conditions: Alcoholic Hepatitis|Acute Alcoholic Hepatitis
Interventions: DRUG: MRG-001
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Combination Chemotherapy Combined With Yttrium Y 90 Ibritumomab Tiuxetan in Treating Older Patients With Previously Untreated B-Cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: darbepoetin alfa|BIOLOGICAL: filgrastim|BIOLOGICAL: rituximab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: indium In 111 ibritumomab tiuxetan|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting
Status: COMPLETED
Conditions: Smoking|Smoking Behaviors|Tobacco Use|Tobacco Smoking
Interventions: OTHER: Non-combusted cigarette variant 42001401|OTHER: Non-combusted cigarette variant 42001399|OTHER: Non-combusted cigarette variant 40007386|OTHER: Non-combusted cigarette variant 42001402
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Designing Animated Movie for Preoperative Period
Status: COMPLETED
Conditions: Postoperative Pain|Fear|Surgery|Pain|Nursing Caries|Nurse's Role|Clinical Anxiety|Patient|Pediatric
Interventions: OTHER: Educational animated movie group|OTHER: Documentary movie group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety Study of SBG vs Placebo in Head and Neck Cancer Patients Undergoing Radiation Therapy
Status: COMPLETED
Conditions: Head and Neck Cancer|Oral Mucositis
Interventions: DRUG: SBG|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Similarity of ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Resected Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: ABP 206|DRUG: FDA-licensed Nivolumab|DRUG: EU-authorized Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Prevention and Treatment Through the Enhancement of the Anti-nociceptive Component of Pain Modulation Profiles
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Duloxetine|DRUG: Pregabalin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Pharmacokinetics, Safety and Tolerability of Zavesca (Miglustat) in Patients With Infantile Onset Gangliosidosis: Single and Steady State Oral Doses
Status: COMPLETED
Conditions: GM2 Gangliosidoses|Tay-Sachs|Sandhoff Disease
Interventions: DRUG: Zavesca (Miglustat)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial
Status: RECRUITING
Conditions: Prostate Adenocarcinoma
Interventions: PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|DRUG: Placebo Administration|DIETARY_SUPPLEMENT: Urolithin A Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC
Status: TERMINATED
Conditions: Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases
Interventions: DRUG: Afatinib|DRUG: Afatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Healthy Eating, Activity, & Lifestyle Training Headquarters: II Pilot Project
Status: ACTIVE_NOT_RECRUITING
Conditions: Overweight|Weight Loss
Interventions: BEHAVIORAL: H.E.A.L.T.H. II Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Efficacy and Safety of Dolutegravir-Containing Versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and Their Infants
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Dolutegravir|DRUG: Emtricitabine/tenofovir alafenamide|DRUG: Emtricitabine/tenofovir disoproxil fumarate|DRUG: Efavirenz/emtricitabine/tenofovir disoproxil fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacological Treatment of Insomnia in Palliative Care
Status: COMPLETED
Conditions: Sleep|Insomnia
Interventions: DRUG: Zopiclone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Testing Atezolizumab in People 2-17 Years Old With Clear Cell Sarcoma or Advanced Chondrosarcoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Central Chondrosarcoma, Grade 2|Central Chondrosarcoma, Grade 3|Dedifferentiated Chondrosarcoma|Metastatic Clear Cell Sarcoma of Soft Tissue|Metastatic Primary Central Chondrosarcoma|Unresectable Primary Central Chondrosarcoma
Interventions: DRUG: Atezolizumab|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CardioFocus vs. Contact Force Guided Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation
Status: COMPLETED
Conditions: Paroxysmal Atrial Fibrillation
Interventions: DEVICE: Ablation catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Positive Airway Pressure (CPAP) for Preventing Respiratory Failure After Laparoscopic Radical Prostatectomy
Status: COMPLETED
Conditions: Continuous Positive Airway Pressure [E02.041.625.790.259]|Prostatectomy [E04.950.774.860.625]|Laparoscopy [E01.370.388.250.520]|Pneumoperitoneum [C06.844.670]
Interventions: DEVICE: Continuous Positive Airway Pressure(CPAP)|DEVICE: Venturi Mask FiO2 40%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MK-2214 in Adults With Mild Cognitive Impairment or Mild-to-Moderate Alzheimer's Disease (MK-2214-002)
Status: RECRUITING
Conditions: Alzheimer Disease
Interventions: BIOLOGICAL: MK-2214|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Conditioning, the Placebo Effect, and Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BEHAVIORAL: Partial schedule of pharmacotherapeutic reinforcement|DRUG: Dose control for Arm B|OTHER: Standard pharmacotherapeutic protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of a Creative Arts en Psychomotor Therapy Intervention for People With Personality Disorders. From Negative Thinking to Positive Doing.
Status: RECRUITING
Conditions: Personality Disorders
Interventions: BEHAVIORAL: Creative arts and psychomotor therapies intervention for people with personality disorders
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Safety and Efficacy of Two Adalimumab Dosing Regimens in Subjects With Moderate to Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis (UC)
Interventions: DRUG: Adalimumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Axillary Approach to Brachial Plexus Blockade Using Ketamine, Regional Versus Intravenous Administration
Status: UNKNOWN
Conditions: Branchial Plexus Blockade|Anesthesia
Interventions: PROCEDURE: Forearm surgey|DRUG: Ropivacaine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sustained Cord Circulation at Emergency Cesarean Section
Status: NOT_YET_RECRUITING
Conditions: Asphyxia Neonatorum|Fetal Hypoxia
Interventions: PROCEDURE: Sustained cord (≥ 180 seconds) resuscitation|PROCEDURE: Routine (< 60 seconds) cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Acceptability Study of Non-occupational Prophylaxis (PEP) Following Potential Exposure to HIV
Status: TERMINATED
Conditions: HIV
Interventions: DRUG: 3 drug regimen: Tenofovir DF and Emtricitabine; Ritonavir-boosted Atazanavir|DRUG: Ritonavir, Atazanavir, Truvada
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of Transcutaneous Electrical Nerve Stimulation on LUTS: One Prospective Study.
Status: UNKNOWN
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: PHENIX4-8-8 PLUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Essential Tremor
Interventions: DRUG: Anlotinib/Penpulimab/Chemotherapy|DRUG: Penpulimab/Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing MRI-Ultrasound Fusion and Cognitive-guided Biopsy for the Detection of csPCa: the PROFUSION Trial
Status: NOT_YET_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: MRI-USG fusion approach|PROCEDURE: Cognitive-guided approach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Acetaminophen in Posterior Fossa Surgery
Status: WITHDRAWN
Conditions: Arnold-Chiari Malformation|Posterior Fossa Tumors
Interventions: DRUG: IV acetaminophen|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose-Escalating Study of BG9924 in Combination With Methotrexate in Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: BG9924
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Probiotic Lysate (Postbiotic and Metabiotic) Supplementation for Adults NAFLD Patients (DELI_NAFLD Study)
Status: COMPLETED
Conditions: Non-Alcoholic Fatty Liver Disease|Non Alcoholic Fatty Liver|Hepatic Steatosis|Fatty Liver
Interventions: DIETARY_SUPPLEMENT: Probiotic lysate (postbiotic and metabiotc)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chlorhexidine Cord Care for Newborn Infants in Kenya
Status: TERMINATED
Conditions: Omphalitis
Interventions: PROCEDURE: Chlorhexidine application to cord by mother|PROCEDURE: Chlorhexidine application by CHW
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Drug-Eluting Balloon Angioplasty for the Treatment of Hemodialysis Vascular Access Stenosis (DEBAVAS)
Status: COMPLETED
Conditions: Dysfunction of Hemodialysis Vascular Access (Fistula and Graft)
Interventions: DEVICE: PTA Balloon dilatation catheter Advance® (Cook® Medical)|DEVICE: Drug-eluting PTA Balloon dilatation catheter Advance® 18 PTX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: 4EVER - Efficacy, Safety, Health Economics, Translational Research of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Exemestane|DRUG: Everolimus (RAD001)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study Using a Pulse Oximeter Derived Photo-plethysmographic Waveform to Guide Hemodialysis Ultrafiltration
Status: COMPLETED
Conditions: Intradialytic Hypotension|Hypervolemia
Interventions: OTHER: Place dialysis chair into position 3.|OTHER: Decrease dialysate temperature.|OTHER: Decrease ultrafiltration rate by 25%.|OTHER: Decrease ultrafiltration rate by 50%.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Stents to Open Restricted Airways in Patients With Centrally Placed Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: OTHER: Arterial puncture|OTHER: Venepuncture|PROCEDURE: General anaesthetic|PROCEDURE: Inpatient stays|OTHER: Walking test|OTHER: Spirometry & flow volume loop assessment|OTHER: Biopsy material
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Prognostic Study of Gastric MALT Lymphoma After Eradication of Helicobacter Pylori
Status: COMPLETED
Conditions: Gastric Low-grade MALT Lymphoma With Helicobacter Pylori Positive
Interventions: DRUG: Rabeprazole Sodium
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: SY-005 （Recombinant Human Annexin A5）in Patients With Sepsis
Status: UNKNOWN
Conditions: Sepsis
Interventions: DRUG: SY-005|DRUG: SY-005|DRUG: SY-005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Oral NAD+ Precursors Administration on Blood NAD+ Concentration in Healthy Adults
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Nicotinamide (NAM)|DIETARY_SUPPLEMENT: Nicotinamide Riboside (NR)|DIETARY_SUPPLEMENT: Nicotinamide Mono Nucleotide (NMN)|DIETARY_SUPPLEMENT: Microcrystalline cellulose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Surgical Resection Versus Percutaneous Local Ablative Therapy for Hepatocellular Carcinoma
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma With CSPH
Interventions: PROCEDURE: SR|PROCEDURE: PLAT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MYL-1401A Efficacy and Safety Comparability Study to Humira®
Status: COMPLETED
Conditions: Psoriasis|Arthritis, Psoriatic
Interventions: BIOLOGICAL: MYL-1401A (Adalimumab)|BIOLOGICAL: Humira® (Adalimumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of ACT in Patients Scheduled for Lumbar Spine Surgery
Status: RECRUITING
Conditions: Randomized Controlled Trial
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy (ACT)|BEHAVIORAL: Treatment as Usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bevacizumab in the Radiation Treatment of Recurrent Malignant Glioma
Status: COMPLETED
Conditions: Brain Cancer|Recurrent Malignant Gliomas|Primary Brain Tumor
Interventions: OTHER: bevacizumab and radiation (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Acute Sauna With Exercise and Sauna
Status: COMPLETED
Conditions: Cardiovascular Risk Factor|Blood Pressure|Arterial Stiffness
Interventions: OTHER: Aerobic exercise|OTHER: Sauna bathing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE