pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Effects of Sacubitril/Valsartan on Subclinical Heart Failure in HIV (The ENCHANTMENT HIV Study)
Status: RECRUITING
Conditions: HIV/AIDS|Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Sacubitril-Valsartan 49-51Mg Oral Tablet|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Pan-vascular Endothelial Growth Factor Receptor (Pan-VEGF) Blockade for the Treatment of Retinopathy of Prematurity (ROP) (Compassionate Use BLOCK-ROP)
Status: NO_LONGER_AVAILABLE
Conditions: Retinopathy of Prematurity
Interventions: DRUG: Bevacizumab (Avastin)
Study Type: EXPANDED_ACCESS
Clinical trial: Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81)
Status: TERMINATED
Conditions: Septic Shock
Interventions: DRUG: OctaplasLG®|DRUG: Ringer-acetat
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action
Status: RECRUITING
Conditions: Lung Cancer|Brain Tumor|Liver Cancer|Ovarian Cancer
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Me-chanical Ventilation - Effects on Cognitive Function
Status: COMPLETED
Conditions: Delirium|Cognition Disorders
Interventions: OTHER: Non-sedation|OTHER: Control: Sedation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Cortical Reorganization Models for Motor Areas and Inter-hemispheric Equilibrium Post-stroke: a Pilot Study
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: Physiotherapy|PROCEDURE: Occupational therapy|PROCEDURE: Functional near-infrared spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Multi-center, National, Open-label, Prospective Study to Evaluate the Performance of the V-Lap™ System
Status: NOT_YET_RECRUITING
Conditions: Heart Failure
Interventions: DEVICE: V-LAP™ SYSTEM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Perioperative Tislelizumab Combined With Nab-Paclitaxel for Muscle-invasive Urothelial Bladder Cancer: A Multicenter Study
Status: RECRUITING
Conditions: Muscle Invasive Bladder Cancer Urothelial Carcinoma
Interventions: DRUG: Tislelizumab Nab paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 443139 in Participants With Early Manifest Huntington's Disease
Status: COMPLETED
Conditions: Huntington's Disease
Interventions: DRUG: ISIS 443139 10 mg|DRUG: ISIS 443139 30 mg|DRUG: ISIS 443139 60 mg|DRUG: ISIS 443139 90 mg|DRUG: ISIS 443139 120 mg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1A Safety Trial of Inhaled PK10571 (GB002)
Status: COMPLETED
Conditions: Safety Issues
Interventions: DRUG: GB002|DEVICE: Generic Dry Powder Inhaler|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Follow up of Neurologic Development of Children Who Presented at the First Trimester of Pregnancy an Isolated Nuchal Anomaly With Normal Karyotype
Status: COMPLETED
Conditions: Neurological Development After Exposition to an Antenatal Nuchal Translucency
Interventions: OTHER: group exposed|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: FAZA PETMRI Gastro-Oesophageal Study
Status: RECRUITING
Conditions: Metastasized Gastro-Oesophageal Cancer
Interventions: DIAGNOSTIC_TEST: FAZA PET/MRI scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Peg-Filgrastim
Status: COMPLETED
Conditions: Chemotherapy-induced Neutropenia|Breast Cancer
Interventions: DRUG: LA-EP2006|DRUG: Neulasta®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Partial Scalp Block in Posterior Fossa Surgery
Status: COMPLETED
Conditions: Posterior Fossa Tumor
Interventions: DRUG: Partial scalp block|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
Status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease
Interventions: DRUG: CRISPR_SCD001
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Liposomal Amikacin for Inhalation (LAI) for Nontuberculous Mycobacteria
Status: COMPLETED
Conditions: Mycobacterium Infections, Nontuberculous
Interventions: DRUG: Liposomal amikacin for inhalation (LAI)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery
Status: COMPLETED
Conditions: Breast Cancer|Breast Cancer Female|Cancer of Breast
Interventions: DRUG: Bupivacaine|DRUG: Gabapentin|DRUG: Celecoxib|DRUG: Acetaminophen|DRUG: Midazolam|DRUG: Fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dysmenorrhea of Emotional Freedom Techniques (EFT) and Its Effect on Perceived Stress Level
Status: ENROLLING_BY_INVITATION
Conditions: Dysmenorrhea Primary|Stress|Emotional Freedom
Interventions: BEHAVIORAL: Emotional Freedom Techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Involved Versus Elective Target SSRS for Spinal Metastases
Status: UNKNOWN
Conditions: Secondary Malignant Neoplasm of Spine
Interventions: RADIATION: Involved Target Stereotacic Spine Radiosurgery|RADIATION: Elective Target Stereotacic Spine Radiosurgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Dexmedetomidine on Early Stage Renal Functions in Pediatric Patients
Status: COMPLETED
Conditions: Renal Function Disorder|Hemodynamic Instability
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine|DRUG: Propofol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PASCA-MM Study. Impact of the PASCA (PArcours de Santé au Cours du CAncer) Program on Complications Associated With Multiple Myeloma and/or Its Treatments in the Context of a First Hematopoietic Stem Cell Autograft, in Adults Aged 18 to 70.
Status: RECRUITING
Conditions: Multiple Myeloma|Complication
Interventions: BEHAVIORAL: Interpretation of the results from the detection visit|BEHAVIORAL: Explaining detection results and referrals to the patient|BEHAVIORAL: Early medical care through the network|BEHAVIORAL: Transmission of results from each detection visit to the referring onco-haematologists - Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Scrambler Therapy in Treating Chronic Pain in Patients With Rash From Varicella Zoster Virus Infection
Status: COMPLETED
Conditions: Dermatologic Complications|Pain|Viral Infection
Interventions: OTHER: scrambler therapy|OTHER: questionnaire administration|PROCEDURE: dermatologic complications management/prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Direct Current Stimulation (tDCS)-Enhanced Stroke Recovery
Status: TERMINATED
Conditions: Ischemic Stroke
Interventions: DEVICE: tDCS|DEVICE: Sham tDCS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain
Status: UNKNOWN
Conditions: Cervicalgia|Low Back Pain
Interventions: DRUG: Botulinum Toxins
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate for Treatment of Hepatitis B e Antigen-Negative Hepatitis B (China)
Status: COMPLETED
Conditions: HBV|Chronic HBV Infections
Interventions: DRUG: TAF|DRUG: TDF|DRUG: TAF Placebo|DRUG: TDF Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Rice Bran Extract in Mildly to Moderately Depressed Adults
Status: COMPLETED
Conditions: Depression
Interventions: DIETARY_SUPPLEMENT: Rice bran extract group|DIETARY_SUPPLEMENT: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Trial Evaluating the Long-term Safety and Efficacy of Dasiglucagon in Children With Congenital Hyperinsulinism
Status: ACTIVE_NOT_RECRUITING
Conditions: Congenital Hyperinsulinism
Interventions: DRUG: dasiglucagon
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pathogenesis and Diagnosis of Mycoplasma Pneumoniae Community-acquired Pneumonia (CAP)
Status: COMPLETED
Conditions: Childhood Pneumonia|Mycoplasma Pneumonia|Antibody-secreting Cells|Enzyme-linked Immunospot (ELISpot)|Diagnosis
Interventions: DIAGNOSTIC_TEST: Enzyme-linked immunospot (ELISpot) assay [Blood]
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Erlotinib in Locally Advanced, Unresectable, or Metastatic Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: Erlotinib|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Learning Performance in Patients With Schizophrenia and Young and Elderly Healthy Volunteers
Status: COMPLETED
Conditions: Schizophrenia
Interventions: BEHAVIORAL: Cognitive Test Battery 1|BEHAVIORAL: Cognitive Test Battery 2
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Bariatric Embolization of Arteries With Imaging Visible Embolics (BEATLES)
Status: COMPLETED
Conditions: Obesity|Morbid Obesity|Weight Loss
Interventions: DEVICE: Bariatric Embolization of Arteries with imaging visible Embolics|OTHER: Control Arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Carbon Dioxide Insufflation During Endoscopy
Status: COMPLETED
Conditions: Carbon Dioxide Insufflation During Colonoscopy
Interventions: PROCEDURE: carbon dioxide insufflation during endoscopy|PROCEDURE: Room air insufflation during endoscopy (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases
Status: TERMINATED
Conditions: Familial Hypoalphalipoproteinemia
Interventions: DRUG: CER-001|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gut Decontamination In Pediatric Allogeneic Hematopoietic
Status: COMPLETED
Conditions: Hematopoietic Stem Cell Transplantation (HSCT)|Acute GVH Disease
Interventions: DRUG: Vancomycin-polymyxin B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
Status: RECRUITING
Conditions: Melanoma|NSCLC|Hepatocellular Carcinoma|Urothelial Cancer|Gastric Adenocarcinoma|HNSCC|Esophageal Adenocarcinoma|Microsatellite Instability-High Solid Malignant Tumor
Interventions: DRUG: Nivolumab or Pembrolizumab (dependent upon approved indication)|DRUG: Metformin|DRUG: Rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: rituximab|DRUG: CHOP regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation
Status: COMPLETED
Conditions: Mechanical Ventilation Pressure High
Interventions: DEVICE: Nasal cannula|DEVICE: Non-invasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity
Status: COMPLETED
Conditions: Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Retinopathy of Prematurity|Blindness
Interventions: PROCEDURE: Supplemental Oxygen Management|PROCEDURE: Conventional Oxygen Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine Hydrochloride and Alvocidib in Treating Patients With Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: gemcitabine hydrochloride|DRUG: alvocidib|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia
Status: NOT_YET_RECRUITING
Conditions: X-linked Hypophosphatemia
Interventions: DRUG: KK8123
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19
Status: COMPLETED
Conditions: Acute Lung Injury (ALI) Associated With COVID-19|Inflammatory Lung Conditions Associated With COVID-19
Interventions: DRUG: TD-0903|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of the Effects of Ferric Citrate in Subjects With End Stage Renal Disease
Status: COMPLETED
Conditions: Hyperphosphatemia|End Stage Renal Disease|ESRD
Interventions: DRUG: ferric citrate|DRUG: ferric citrate|DRUG: ferric citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults
Status: UNKNOWN
Conditions: Mild Cognitive Impairment|Exercise Training
Interventions: BEHAVIORAL: Exergame|BEHAVIORAL: Cycling|BEHAVIORAL: Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Reproductive and Obstetric Outcomes in TESE-ICSI Cycles for Azoospermia
Status: COMPLETED
Conditions: Obstructive Azoospermia|Non-obstructive Azoospermia|Obstetric Complication
Interventions: PROCEDURE: ICSI-TESE; embryo-transfer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Explore the Role of Gut Flora in COVID-19 Infection
Status: RECRUITING
Conditions: Gut Microbiome|Gastrointestinal Microbiome|COVID|COVID-19|Corona Virus Infection|Coronavirus|Coronaviridae Infections|Coronavirus 19|Coronavirus-19|COVID 19
Interventions: OTHER: There is no intervention in this study
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Influence of Obesity to Esophageal Reflux Severity Measured by pH-Metri Impedans on Gastroesophageal Reflux Disease Patients
Status: COMPLETED
Conditions: Disorder of Upper Esophageal Sphincter
Interventions: DIAGNOSTIC_TEST: MII pH-meter
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Yttrium-90 Radioembolization Using Glass Microspheres (TheraSphere) for Patients With Liver Metastases
Status: COMPLETED
Conditions: Colorectal Neoplasms|Neuroendocrine Tumors|Cholangiocarcinoma|Melanoma|Breast Cancer
Interventions: DEVICE: Selective internal radiation therapy to the liver using Yttrium-90 glass microspheres (TheraSphere)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection
Status: COMPLETED
Conditions: Invasive Fungal Infection
Interventions: DRUG: Itraconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Optical Clearing of the Skin in Conjunction With Laser Treatments
Status: COMPLETED
Conditions: Port Wine Stain|Nevus of Ota|Tattoos|Scars|Acne|Hypertrichosis|Sebaceous Gland Diseases
Interventions: DEVICE: Optical Clearing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physical Cold Atmospheric Plasma for the Treatment of Cervical Intraepithelial Neoplasia
Status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Interventions: PROCEDURE: CAP treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Chronic Prostatitis/ Pelvic Pain Syndrome With Low-intensity Extracorporeal Shockwave Therapy
Status: UNKNOWN
Conditions: Chronic Prostatitis/ Pelvic Pain Syndrome
Interventions: DEVICE: low energy extracorporeal shockwave therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Long Term Safety Trial to Compare Insulin Treatment With Preprandial Inhaled Human Insulin to s.c. Insulin Aspart Both Combined With NPH in Subjects With Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: inhaled human insulin|DRUG: insulin aspart|DRUG: insulin NPH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Electric Stimulation Therapy in Raynaud's Phenomenon
Status: COMPLETED
Conditions: Raynaud Phenomenon|Raynaud Disease
Interventions: OTHER: Electrotherapy with Galvanic Current|OTHER: Control without Electric Stimulation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Anticipatory & Preventive Team Care (APTCare): At Risk Patients of Family Health Networks
Status: UNKNOWN
Conditions: Diabetes|Chronic Obstructive Pulmonary Disease|Congestive Heart Failure|Hypertension
Interventions: BEHAVIORAL: Self-management of chronic illness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Communities Fighting COVID-19!
Status: COMPLETED
Conditions: Covid19
Interventions: OTHER: COVID-19 Testing Home-based (Aim 1)|OTHER: COVID-19 Testing Mobile (Aim 1)|OTHER: COVID-19 Testing Mobile Approach 1 (Aim 2)|OTHER: COVID-19 Testing Mobile Approach 2 (Aim 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Trial of Vitamin D Therapy in Patients With Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol|DIETARY_SUPPLEMENT: Cholecalciferol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Effectiveness and Safety of ELIOS in Patients With Open-Angle Glaucoma Undergoing Cataract Surgery
Status: RECRUITING
Conditions: Open Angle Glaucoma
Interventions: PROCEDURE: ELIOS|PROCEDURE: Competitor Device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination of BTK Inhibitor Overcomes Drug-resistance in Refractory/Relapsed FLT3 Mutant AML
Status: UNKNOWN
Conditions: FLT3-ITD Mutation|Acute Myeloid Leukemia|Brutons Tyrosine Kinase
Interventions: DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/IIa Sporozoite Challenge Study to Assess the Efficacy of Candidate Combination Malaria Vaccine Approaches Using the ChAd63 and MVA Vectors Encoding the Antigens ME-TRAP, CS and AMA1
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: ChAd63 CS/ME-TRAP|BIOLOGICAL: MVA CS/ME-TRAP|BIOLOGICAL: ChAd63 CS/ME-TRAP/AMA1|BIOLOGICAL: MVA CS/ME-TRAP/AMA1|OTHER: Controlled Human Malaria Infection Administered by Mosquito Bite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Daratumumab, Thalidomide and Dexamethasone in Relapse and/or Refractory Myeloma
Status: UNKNOWN
Conditions: Relapse and / or Refractory Myeloma
Interventions: DRUG: Daratumumab, thalidomide and dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of Blunt Needles for the Reduction of Needlestick Injuries During Cesarean Section
Status: COMPLETED
Conditions: Glove Perforations|Needlestick Injuries
Interventions: DEVICE: Sharp needle|DEVICE: Blunt needles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase 1, Open-label Trial of Oral Azacitidine (CC-486) Plus RCHOP in Subjects With Large B-Cell Lymphoma or Follicular Lymphoma or Transformed Lymphoma
Status: COMPLETED
Conditions: Lymphoma, Large B-Cell, Diffuse|Lymphoma, Follicular
Interventions: DRUG: Oral Azacitidine|DRUG: Rituximab|DRUG: cyclophosphamide|DRUG: Vincristine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial of Neoadjuvant Endostar, Docetaxel and Epirubicin for Patients With Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: docetaxel and epirubicin|DRUG: docetaxel and epirubicin plus endostatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Telmisartan Versus Ramipril After Acute Coronary Syndrome
Status: UNKNOWN
Conditions: Acute Coronary Syndrome|Myocardial Infarction|Coronary Disease
Interventions: DRUG: TELMISARTAN|DRUG: RAMIPRIL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of MEK162 and Paclitaxel in Patients With Epithelial Ovarian, Fallopian Tube or Peritoneal Cancer
Status: COMPLETED
Conditions: Epithelial Ovarian Cancer|Fallopian Tube Cancer|Peritoneal Cancer
Interventions: DRUG: MEK162, MEK inhibitor; oral|DRUG: Paclitaxel, mitotic inhibitor; intravenous
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gait Speeds and Demands in Chronic Stroke Patients: A Multi-dimensional Investigation
Status: UNKNOWN
Conditions: Stroke
Interventions: OTHER: Treadmill walking training with random speed changes|OTHER: Treadmill walking training with blocked speed changes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Supplementation and Attention-deficit-hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DIETARY_SUPPLEMENT: omega-3 fatty acid alpha-linolenic acid (ALA)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated, c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: INC280|DRUG: Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-electrode PulmonarY Vein Isolation Versus Single Tip Wide Area Catheter Ablation for Paroxysmal Atrial Fibrillation (PAF)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: Cardiac ablation for Atrial Fibrillation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)
Status: RECRUITING
Conditions: Cardiac Surgery
Interventions: OTHER: Continuous low-tidal volume ventilation with using FiO2 of 0.21|OTHER: Continuous low tidal volume ventilation with using FiO2 of 1.0|OTHER: Apnea During CPB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine
Status: ACTIVE_NOT_RECRUITING
Conditions: Vivax Malaria|Plasmodium Vivax|Malaria, Vivax|Malaria Relapse
Interventions: DRUG: Tafenoquine|DRUG: Primaquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study
Status: COMPLETED
Conditions: Endometrial Stromal Sarcoma|Adenosarcoma of Uterus|Leiomyosarcoma Uterus|Endometrial Cancer|Sex Cord Stromal Tumor|Serous Ovarian Tumor
Interventions: DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Test An Anti-Rejection Therapy After Kidney Transplantation
Status: TERMINATED
Conditions: Kidney Transplantation
Interventions: DRUG: hOKT3|DRUG: Oral Cyclosporine|DRUG: IV Cyclosporine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Long Term Follow-up of a Study to Assess the Safety and Immunogenicity of a Hepatitis A Vaccine Administered With and in the Absence of DTPaHibIPV, OPV and MMR Vaccines
Status: COMPLETED
Conditions: Hepatitis A
Interventions: BIOLOGICAL: Epaxal|BIOLOGICAL: Havrix 720
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Subcutaneous Implant Combination Product (AUR-201) in Patients With Unilateral Microtia (Australia)
Status: ENROLLING_BY_INVITATION
Conditions: Microtia
Interventions: COMBINATION_PRODUCT: AUR-201
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose
Status: COMPLETED
Conditions: Meningococcal Disease
Interventions: BIOLOGICAL: Meningococcal (groups A, C, W, and Y) oligosaccharide diphtheria CRM-197 conjugate vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Equivalence Study of Mometasone Nasal Spray, 50 Mcg/Actuation
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Mometasone furoate|DRUG: Nasonex®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Chemoradiotherapy of Capecitabine With or Without Oxaliplatin Versus Cisplatin-5-FU for Esophageal Squamous Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage III Esophageal Squamous Cell Carcinoma|Stage II Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Capecitabine(Aibin)|DRUG: Oxaliplatin(Aiheng)|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Safety, Deliverability and Efficacy of the Medtronic Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System in the Treatment of Suitable Patients According to Indication for Use (CHINA RESOLUTE INTEGRITY STUDY)
Status: COMPLETED
Conditions: Ischemic Heart Disease|Cardiovascular Diseases|Arteriosclerosis|Coronary Artery Disease
Interventions: DEVICE: Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Migration and Bone Density Study Comparing 2 Types of Bone Cement in the OptiPac Bone Cement Mixing System
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: OTHER: Refobacin Bone Cement R|OTHER: Refobacin Plus Bone Cement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study on Mannan Binding Lectin (MBL) Substitution in MBL-Deficient Children With Chemotherapy-Induced Neutropenia
Status: COMPLETED
Conditions: MBL-Deficient|Neutropenia
Interventions: DRUG: Mannan Binding Lectin (MBL)|DRUG: Mannan Binding Lectin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sintilimab for the Treatment of Locally Advanced, Metastatic, or Recurrent Angiosarcoma, the SiARa Cancer Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Angiosarcoma|Metastatic Angiosarcoma|Recurrent Angiosarcoma
Interventions: OTHER: Quality-of-Life Assessment|BIOLOGICAL: Sintilimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery
Status: WITHDRAWN
Conditions: Laparoscopic Colorectal Resection Due to Cancer
Interventions: DRUG: IV ketamine/lidocaine/IV PCA apply|DRUG: IV PCA only apply
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Suvorexant in Insomnia Co-morbid With Fibromyalgia
Status: TERMINATED
Conditions: Insomnia|Fibromyalgia
Interventions: DRUG: suvorexant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
Status: COMPLETED
Conditions: Knee Injuries
Interventions: DEVICE: BST-CarGel with Microfracture|PROCEDURE: Microfracture without BST-CarGel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gametes Transfer vs. Embryo Transfer for Women Undergoing Assisted Reproductive Techniques: a Randomized Controlled Trial
Status: TERMINATED
Conditions: Infertility
Interventions: PROCEDURE: Intrauterine transfer of gametes|PROCEDURE: Intrauterine transfer of embryos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allium Sativum Extract as an Irrigant
Status: COMPLETED
Conditions: Infected Root Canals of Primary Molars
Interventions: OTHER: Garlic extract|OTHER: NaOCl (COLTENE®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multisite Tissue Oxygenation Guided Perioperative Care in Cardiac Surgery
Status: COMPLETED
Conditions: Brain Ischemia Hypoxia|Muscle; Ischemic|Muscle Hypoxia
Interventions: OTHER: Multisite tissue oxygenation-guided care|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Different Stylet Angles for Orotracheal Intubation Using C-MAC® Video Laryngoscopes in Infants
Status: COMPLETED
Conditions: Intubation
Interventions: OTHER: Style curve similar to natural curvature of endotracheal tube|OTHER: Style curve similar to hockey stick shape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Perioperative Oral Nutritional Support for Patients Having Surgery for Colon Cancer, Peri-Nutri
Status: RECRUITING
Conditions: Colon Cancer|Sarcopenia
Interventions: DIETARY_SUPPLEMENT: regular diet|DIETARY_SUPPLEMENT: nutritional support Resource 2.5
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: DyeVert System and Contrast-induced Acute Kidney Injury
Status: COMPLETED
Conditions: Contrast-induced Acute Kidney Injury|Acute Coronary Syndromes
Interventions: DEVICE: Coronary angiography using DyeVert system|PROCEDURE: Coronary angiography using conventional manual injection syringe.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Combined Thoracoscopic and Laparoscopic Esophagectomy vs. Hand-assisted Transhiatal Esophagectomy: A Prospective Trial.
Status: WITHDRAWN
Conditions: Adenocarcinoma
Interventions: PROCEDURE: Laparoscopic Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Camrelizumab (SHR-1210) vs. Chemotherapy in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma
Status: UNKNOWN
Conditions: Classical Hodgkin Lymphoma
Interventions: DRUG: Camrelizumab|DRUG: Investigator's choice of Chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
Status: COMPLETED
Conditions: Acute Pain
Interventions: DRUG: VX-548|DRUG: HB/APAP|DRUG: Placebo (matched to VX-548)|DRUG: Placebo (matched to HB/APAP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI)
Status: RECRUITING
Conditions: Dementia of Alzheimer Type
Interventions: BEHAVIORAL: Physical activity program|BEHAVIORAL: Successful Aging
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospectively Predict the Immunotherapy Response of Gastric Cancer Based on Circulating Exosomal LncRNA-GC1 Biopsy
Status: COMPLETED
Conditions: Advanced Gastric Carcinoma|Immunotherapy
Interventions: DEVICE: Circulating exosomal lncRNA-GC1 detection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer
Status: RECRUITING
Conditions: Metastatic Malignant Neoplasm
Interventions: RADIATION: Palliative Radiation Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|RADIATION: Stereotactic Body Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation- Treatment Use Study
Status: TERMINATED
Conditions: Heart Diseases|Arrhythmia|Atrial Fibrillation
Interventions: DEVICE: Radiofrequency Ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Rehabilitation in Patients With Stable Chronic Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Aerobic Exercise|Quality of Life|Respiratory Muscle Training|Strength Training|Exercise Intolerance|Cardiac Rehabilitation
Interventions: OTHER: Aerobic training|OTHER: Inspiratory muscle training|OTHER: Resistance Training|OTHER: Aerobic and Inspiratory training|OTHER: Combined
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Renin Angiotensin System Study (RASS/B-RASS)
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: DRUG: enalapril|DRUG: losartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Status: RECRUITING
Conditions: Type 2 Diabetes|Healthy Aging
Interventions: DRUG: Trehalose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Transcranial Magnetic Stimulation (TMS) and Obsessive Compulsive Disorder (OCD)
Status: COMPLETED
Conditions: Obsessive-Compulsive Disorder
Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS)|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thromboembolic Risk Assessment in Patients Admitted With Acute Medical Diseases to Conventional and At Home Hospitalization
Status: RECRUITING
Conditions: Thromboprophylaxis|Thromboembolism, Venous|Atrial Fibrillation|Physical Inactivity|Hospital at Home
Interventions: DEVICE: Triaxial accelerometry
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Extracorporeal Photopheresis of Patients With Crohn's Disease Using 5-aminolevulinic Acid
Status: COMPLETED
Conditions: Crohn Disease
Interventions: DRUG: 5-aminolevulinic acid|PROCEDURE: Blue light photopheresis|PROCEDURE: Transfusion|PROCEDURE: Continuous Mononuclear Cell Collection (CMNC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Evaluate the Leish-111f + MPL-SE Vaccine in the Prevention of Cutaneous Leishmaniasis in Healthy Subjects Previously Exposed to the Leishmania Parasite
Status: COMPLETED
Conditions: Cutaneous Leishmaniasis
Interventions: BIOLOGICAL: Leish-111f + MPL-SE vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Trial Comparing Side-to-Side Stapled and Hand-sewn Esophagogastric Anastomosis in Neck
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: PROCEDURE: side-to-side stapled|PROCEDURE: hand sewn
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Supplementation and Depression Clinical Trial
Status: COMPLETED
Conditions: Depressive Symptoms
Interventions: DIETARY_SUPPLEMENT: Soybean oil soft gels|DIETARY_SUPPLEMENT: Fish oil omega-3 EPA-rich soft gels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate the Safety and Efficacy of PB-201 in Treatment-naive Patients With Type 2 Diabetes Mellitus
Status: RECRUITING
Conditions: Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: PB-201|DRUG: Vildagliptin|DRUG: PB-201 matched placebo|DRUG: Vildagliptin matched placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: To Study the Nutri-Genomic Response of Vit-D Supplementation in African-Americans
Status: COMPLETED
Conditions: Hypovitaminosis D
Interventions: DRUG: 25 Hydroxy- Vitamin D3 [25 (OH) D3]|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Temsirolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Adult Giant Cell Glioblastoma|Adult Glioblastoma|Adult Gliosarcoma
Interventions: OTHER: pharmacological study|PROCEDURE: adjuvant therapy|RADIATION: 3-dimensional conformal radiation therapy|RADIATION: intensity-modulated radiation therapy|DRUG: temsirolimus|DRUG: temozolomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine Versus Dexamethasone as Adjuncts in Erector Spinae Plane Block in Modified Radical Mastectomy
Status: COMPLETED
Conditions: Breast Cancer|Post Operative Pain
Interventions: PROCEDURE: Adjuncts to levobupivacaine in Erector Spinae Plane Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MyoRing Implantation With Corneal Collagen Crosslinking for Keratoconus
Status: COMPLETED
Conditions: Keratoconus
Interventions: PROCEDURE: Corneal Collagen Crosslinking|DEVICE: Ufalink
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimal Antiplatelet Therapy Following Left Atrial Appendage Closure
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: short postimplantation dual antiplatelet therapy|DRUG: extended postimplantation dual antiplatelet therapy|DRUG: long-term treatment with a single antiplatelet agent|DRUG: 6 months treatment with a single antiplatelet agent
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Spontaneous Ventilation Time in Air Without Desaturation After Positive Pressure Extubation Versus Aspiration Extubation When Awakening From General Anesthesia
Status: COMPLETED
Conditions: Anesthesia, General
Interventions: PROCEDURE: Positive pressure extubation|PROCEDURE: Aspiration/suction extubation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Brief Intervention for Tobacco and Alcohol Risk Reduction for Couple During Breast Cancer Treatment.
Status: UNKNOWN
Conditions: Breast Cancer|Smoking Cessation|Alcohol Use, Unspecified
Interventions: BEHAVIORAL: Brief motivational interview on tobacco/alcohol risk reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER