pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trial With BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Anti-PD-1-refractory/Relapsed, Unresectable Stage III or IV Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma Stage III|Melanoma Stage IV|Unresectable Melanoma
Interventions: BIOLOGICAL: BNT111|BIOLOGICAL: Cemiplimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interest of the Virtual Reality as an Analgesic Support and in the Management the Pre-procedural Anxiety in Rheumatology
Status: UNKNOWN
Conditions: Radiculopathy
Interventions: DEVICE: Virtual reality headset for first injection|DEVICE: Virtual reality headset for second injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Determine Efficacy & Safety of a Low Concentration Estriol (0.005%) in Postmenopausal Vaginal Atrophy.
Status: COMPLETED
Conditions: Vaginal Atrophy
Interventions: DRUG: Estriol|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Baricitinib When Administered With Ketoconazole or Fluconazole in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Baricitinib|DRUG: Ketoconazole|DRUG: Fluconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major
Status: COMPLETED
Conditions: Thalassemia|Iron Overload
Interventions: DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer
Status: COMPLETED
Conditions: Accelerated Phase Chronic Myelogenous Leukemia|Adult Acute Lymphoblastic Leukemia in Remission|Adult Acute Myeloid Leukemia in Remission|Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities|Adult Acute Myeloid Leukemia With Del(5q)|Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)|Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)|Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)|Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)|B-cell Chronic Lymphocytic Leukemia|Childhood Acute Lymphoblastic Leukemia in Remission|Childhood Acute Myeloid Leukemia in Remission|Childhood Chronic Myelogenous Leukemia|Childhood Myelodysplastic Syndromes|Childhood Renal Cell Carcinoma|Chronic Phase Chronic Myelogenous Leukemia|Clear Cell Renal Cell Carcinoma|de Novo Myelodysplastic Syndromes|Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Previously Treated Myelodysplastic Syndromes|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult Diffuse Small Cleaved Cell Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Marginal Zone Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent Small Lymphocytic Lymphoma|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Refractory Multiple Myeloma|Relapsing Chronic Myelogenous Leukemia|Splenic Marginal Zone Lymphoma|Stage III Renal Cell Cancer|Stage IV Renal Cell Cancer|T-cell Large Granular Lymphocyte Leukemia|Type 1 Papillary Renal Cell Carcinoma|Type 2 Papillary Renal Cell Carcinoma|Waldenström Macroglobulinemia
Interventions: DRUG: fludarabine phosphate|RADIATION: total-body irradiation|PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation|PROCEDURE: allogeneic bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cyclosporine|DRUG: mycophenolate mofetil|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Southeast Asia Dose Optimization of Tafenoquine
Status: RECRUITING
Conditions: Plasmodium Vivax Malaria
Interventions: DRUG: Tafenoquine|DRUG: Chloroquine|DRUG: Artemether 20 mg-Lumefantrine 120 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Food Order on Glycemic Excursions in Type 2 Diabetes Assessed by Continuous Glucose Monitoring
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: BEHAVIORAL: Carbohydrate-Last Meal Sequence|BEHAVIORAL: Carbohydrate-First Meal Sequence
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Study of the Efficacy of Early Intervention With Secukinumab 300 mg s.c. Compared to Narrow-band UVB in Patients With New-onset Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Plaque Psoriasis
Interventions: BIOLOGICAL: Secukinumab|RADIATION: nb-UVB|DRUG: Calcipotriol|DRUG: Betamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: mFOLFOXIRI Compared to mFOLFOX6 or CapeOx as Adjuvant Chemotherapy for Stage IIIB or IIIC Colorectal Cancer
Status: RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: mFOLFOXIRI|DRUG: mFOLFOX6 OR CapeOx
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum
Status: COMPLETED
Conditions: Malaria in Pregnancy|HIV Infection
Interventions: DRUG: cotrimoxazole daily prophylaxis|DRUG: sulphadoxine-pyrimethamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Study of Fruquintinib Combined With Sintilimab and TACE for Inoperable Primary Hepatocellular Carcinoma
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Fruquintinib|DRUG: Sintilimab|DEVICE: Transcatheter arterial chemoembolization（TACE）
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Everolimus, Cytarabine, and Daunorubicin in Treating Patients With Relapsed Acute Myeloid Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: everolimus|OTHER: laboratory biomarker analysis|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Symfony Toric Intraocular Lens Visual Outcomes
Status: COMPLETED
Conditions: Cataract Bilateral|Astigmatism Bilateral
Interventions: DEVICE: Presbyopia and astigmatism correcting intraocular lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate Azvudine in Preventing SARS-Cov-2 Infection in Household Contacts of Covid-19 in China
Status: RECRUITING
Conditions: COVID-19
Interventions: DRUG: Azvudine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Measurement and Training of Dual-Task of Gait in Persons With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis|Gait Disorders, Neurologic|Cognitive Impairment
Interventions: OTHER: Dual-task gait|OTHER: Single-task gait
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of an Arabic Central Auditory Processing Remediation Program for Dyslexic Children With(C)APD
Status: COMPLETED
Conditions: Central Auditory Processing Disorder|Dyslexia
Interventions: BEHAVIORAL: arabic version of differential processing training program|BEHAVIORAL: Arabic computer based auditory traing program(CBAT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thrombocytopoiesis and Platelet Homeostasis in Infants With Bronchoplumonary Dysplasia
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia|Thrombocytopenia|Preterm Infant
Interventions: OTHER: BPD
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-ranging Study in Patients With Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DRUG: Placebo|DRUG: Sotagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Caffeine Intake in Vestibular Function
Status: COMPLETED
Conditions: Vertigo|Diseases, Vestibular|Caffeine
Interventions: DIETARY_SUPPLEMENT: Caffeine|DIETARY_SUPPLEMENT: Non caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparing PET-CT Using C-11 Choline and 18F-Fluoromethylcholine in Patients With Metastatic Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: C-11 choline|RADIATION: 18F-fluoromethylcholine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy, Safety, and Acceptability of Mifepristone 50 mg Once-weekly as a Contraceptive
Status: NOT_YET_RECRUITING
Conditions: Female Contraception
Interventions: DRUG: Mifepristone 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of 14-day Concomitant Therapy for Helicobacter Pylori Infection
Status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: esomeprazole, amoxicillin, furazolidone，tetracycline
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Versus Intravenous Dexmedetomidine for Hypotensive Anesthesia in FESS
Status: COMPLETED
Conditions: Functional Endoscopic Sinus Surgery|Premedication|Analgesia
Interventions: DRUG: Intranasal dexmedetomidine|DRUG: Intravenous dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Autologous Adipose-Derived Stem Cell Transplantation in Patients With Type 1 Diabetes
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus
Interventions: PROCEDURE: Autologous Adipose-derived Stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effects of Mid-Thoracic Spinal Manipulation and Spinal Mobilization on Heart Rate Variability
Status: UNKNOWN
Conditions: Physiology of Manipulation / Mobilization in Healthy Adults
Interventions: OTHER: Spinal Manipulation|OTHER: Spinal Mobilization|OTHER: Sham Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular Degeneration
Status: COMPLETED
Conditions: Diabetic Macular Edema|Age-related Macular Degeneration
Interventions: DRUG: MTP-131
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 12-Month Study Comparing Fluticasone Propionate/Salmeterol (ADVAIR) DISKUS Combination Product 250/50mcg BID To Fluticasone Propionate (FLOVENT) DISKUS 250 mcg BID In Symptomatic Subjects With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone Propionate/salmeterol xinofoate 250/50 mcg BID|DRUG: Fluticasone propionate 250 mcg BID
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Aspirin in Patients With Vestibular Schwannoma
Status: RECRUITING
Conditions: Vestibular Schwannoma|Acoustic Neuroma|Neurofibromatosis 2
Interventions: DRUG: Aspirin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Selinexor in Combination With Temozolomide and Anti-PD-1 Antibody in Patients With Relapsed/Refractory Primary Central Nervous System Lymphoma
Status: RECRUITING
Conditions: Relapsed/Refractory Primary Central Nervous System Lymphoma
Interventions: DRUG: Selinexor|DRUG: Temozolomide|DRUG: Anti-PD-1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Combination of Orange- and Pomegranate Actives on Physical Fitness in Elderly People
Status: COMPLETED
Conditions: Fitness
Interventions: DIETARY_SUPPLEMENT: Actiful|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Autologous Gene Therapy for Artemis-Deficient SCID
Status: RECRUITING
Conditions: Severe Combined Immunodeficiency
Interventions: DRUG: AProArt|DEVICE: CliniMACS® CD34 Reagent System cell sorter device|DRUG: Busulfan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High vs Low Dose Vitamin D in Patients With Diabetic Peripheral Neuropathy
Status: COMPLETED
Conditions: Diabetes Type 2|Diabetic Neuropathies|Vitamin D Deficiency
Interventions: DRUG: Vitamin D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability, and Pharmacokinetics of E2307 in Healthy Young and Elderly Japanese Subjects
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: E2307|DRUG: E2307 Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Daily Caloric Restriction in ADPKD
Status: RECRUITING
Conditions: Autosomal Dominant Polycystic Kidney|Overweight and Obesity
Interventions: BEHAVIORAL: Daily caloric restriction|OTHER: Standard advice control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia
Status: UNKNOWN
Conditions: Critical Limb Ischemia|Peripheral Arterial Disease - PAD|Ischemic Ulcer|Ischemic Feet|Diabetic Foot|Scleroderma, Systemic|Thrombo Angiitis Obliterans|Ischemic Leg
Interventions: PROCEDURE: Autologous Fat Grafting
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Panobinostat (DACi) Pharmacokinetics and Safety in Solid Tumors and Varying Renal Function
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: panobinostat (LBH589)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The Efficacy and Safety of Pegylated Liposomal Doxorubicin Compared With Capecitabine as First Line Chemotherapy for Metastatic Breast Cancer (P04445/MK-2746-071)
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Pegylated liposomal doxorubicin (SCH 200746)|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Internet-Based Lifestyle Intervention (iLIVE) to Eradicate Obese Frailty in Prostate Cancer Survivors
Status: RECRUITING
Conditions: Prostate Carcinoma
Interventions: OTHER: Internet-Based Exercise Intervention|OTHER: Internet-Based Diet Intervention|OTHER: Education Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prevalence of Diabetic Retinopathy in Type 2 Diabetic Patients
Status: NOT_YET_RECRUITING
Conditions: Diabetic Retinopathy
Interventions: DEVICE: Optical Coherence Tomography (OCT)|DEVICE: Fundus fluorescein angiography (FFA)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Mesenchymal Stem Cells Combined With Cord Blood for Treatment of Graft Failure
Status: UNKNOWN
Conditions: Hematopoietic Stem Cell Transplantation|Mesenchymal Stem Cells|Umbilical Cord Blood|Graft Failure|Hematological Diseases
Interventions: BIOLOGICAL: Mesenchymal stem cells|BIOLOGICAL: Mesenchymal stem cells and cord blood
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Methadone for Patients Undergoing Cardiac Surgery: Reduction of Postoperative Pain
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Methadone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Negative, Chronic Hepatitis B Virus (HBV) Infection
Status: TERMINATED
Conditions: Hepatitis B
Interventions: DRUG: ARC-520 Injection|OTHER: placebo|DRUG: entecavir|DRUG: tenofovir|DRUG: antihistamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Association of Genetic Polymorphisms With Capecitabine-based Chemotherapy Toxicities in Chinese Solid Tumor Patients
Status: UNKNOWN
Conditions: Solid Tumor|Capecitabine|Drug-Related Side Effects and Adverse Reactions|Pharmacogenetics|Pharmacokinetics
Interventions: GENETIC: detection of genotype
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparing the Outcome of Two Intraoperative Analgesia Techniques After Hepato-pancreato-biliary Surgery
Status: UNKNOWN
Conditions: Pain|Analgesia|Sedation
Interventions: DRUG: Intrathecal morphine|DRUG: Continuous IV remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: AZD7268 Safety and Tolerability Study
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: AZD7268|DRUG: Escitalopram|DRUG: Placebo capsules|DRUG: Placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fat Burning After a Meal
Status: COMPLETED
Conditions: Postprandial Effect of Carbohydrate Beverage Consumption
Interventions: OTHER: 15% protein|OTHER: 30% protein|OTHER: Sweetened beverage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Lanabecestat in Healthy Female Participants Taking Oral Contraceptive
Status: WITHDRAWN
Conditions: Healthy
Interventions: DRUG: Lanabecestat|DRUG: Oral Contraceptive
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexmedetomidine and Intelligence Development in Pediatric Patients Undergoing Craniotomy
Status: COMPLETED
Conditions: Brain Neoplasms
Interventions: DRUG: dexmedetomidine|DRUG: normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Application and Research of Mesenchymal Stem Cells in Alleviating Severe Development of COVID-19 Infection
Status: RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Umbilical cord mesenchymal stem cells implantation|OTHER: Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of Neramexane Mesylate in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Neramexane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: A Study to Assess the Effects of MK0822 in Prolonging Time to First Bone Metastasis in Men With Castration-Resistant Prostate Cancer (0822-030)
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: odanacatib|DRUG: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Safety Study of Eptifibatide in Patients With Sickle Cell Disease
Status: TERMINATED
Conditions: Sickle Cell Disease
Interventions: DRUG: Eptifibatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Comprehensive Intervention on Hypertension（HTN） and Type 2 Diabetes Mellitus（DM） at PHC Level
Status: UNKNOWN
Conditions: Hypertension|Diabetes Mellitus, Type 2
Interventions: OTHER: Implementation strategies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol
Status: COMPLETED
Conditions: Cytomegalovirus Retinitis|HIV Infections
Interventions: DRUG: Cidofovir|DRUG: Probenecid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effect of Coconut Milk Supplementation to Improve Nutritional Status in Cirrhosis Patient
Status: COMPLETED
Conditions: Malnutrition|Cirrhosis, Liver
Interventions: DIETARY_SUPPLEMENT: coconut milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Assessment of the Cytotoxic Immune Status of Pancreatic Cancer Patients and the Severity of the Cancer Using Measurement of Natural Killer Cell Activities
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: PROCEDURE: Blood collection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Open Label Extension to Assess the Long-Term Safety and Tolerability of ZYN002 in Children and Adolescents With FXS
Status: ENROLLING_BY_INVITATION
Conditions: Fragile X Syndrome
Interventions: DRUG: ZYN002 - Cannabidiol Transdermal Gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta
Status: COMPLETED
Conditions: Non-steroidal Anti-inflammatory Poisoning
Interventions: DRUG: cataflam (diclofenac potassium)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemo, Rituximab, and Bevacizumab in Older Patients With Stage II-IV Diffuse Large B-Cell Lymphoma
Status: COMPLETED
Conditions: Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma
Interventions: BIOLOGICAL: rituximab|BIOLOGICAL: bevacizumab|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: vincristine sulfate|DRUG: prednisone|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of a Hyperinflation Mode and Air Stacking on Neuromuscular Patients Under Volumetric Ventilation
Status: COMPLETED
Conditions: Neuromuscular Disease
Interventions: DEVICE: increase of cough peak flow ("Astral ventilator")
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: VT Cryoablation System Post-Market Clinical Follow-up (PMCF) Study
Status: NOT_YET_RECRUITING
Conditions: Ventricular Tachycardia
Interventions: DEVICE: VT Cryoablation System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative Pneumonia
Status: COMPLETED
Conditions: Pneumonia, Bacterial
Interventions: DRUG: Amikacin fosfomycin inhalation solution|DRUG: Aerosolized placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: agomelatine|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protein-rich Diet and NAFLD in Bariatric Surgery
Status: UNKNOWN
Conditions: Obesity|Non-alcoholic Fatty Liver Disease
Interventions: DIETARY_SUPPLEMENT: High-protein low calorie diet|DIETARY_SUPPLEMENT: Control low calorie diet|OTHER: Anthropometrical measurements|OTHER: Body composition|OTHER: 8-h metabolic profile|OTHER: Liver biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort
Status: COMPLETED
Conditions: Influenza|Hepatitis A|Typhoid|Healthy Adults
Interventions: BIOLOGICAL: Fluzone® quadrivalent|BIOLOGICAL: Fluzone High Dose|BIOLOGICAL: Fluad|BIOLOGICAL: Vaqta|BIOLOGICAL: Typhim Vi|BIOLOGICAL: Vivotif
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412)
Status: ACTIVE_NOT_RECRUITING
Conditions: Head and Neck Neoplasms
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Placebo|DRUG: Cisplatin|RADIATION: Accelerated Fractionation (AFX) Radiotherapy|RADIATION: Standard Fractionation (SFX) Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid
Status: NOT_YET_RECRUITING
Conditions: Ketosis
Interventions: DIETARY_SUPPLEMENT: Ketone Ester|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Use of Chamomilla Recutita in Phlebitis
Status: COMPLETED
Conditions: Phlebitis
Interventions: OTHER: compress of Chamomilla recutita infusion|OTHER: compress of lukewarm water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Retention of CAD Metallic and Poly Ether Ether Ketone (PEEK) Frameworks
Status: NOT_YET_RECRUITING
Conditions: Retention
Interventions: PROCEDURE: CAD PEEK frame-work
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of an Antibody to CCR5 in Individuals With HIV Who Are Not Currently on Antiretroviral Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: CCR5mAb004
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Post-FESS Implantation of Composite Removable Sinus Stent to Prevent Post-Operative Complications
Status: UNKNOWN
Conditions: Chronic Sinusitis
Interventions: DEVICE: Composite Removable Sinus Stent|DRUG: adrenaline-lidocaine|PROCEDURE: cold saline wash
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Parallel-controlled Study Comparing the Ileostomy "Dumpling Suture Method" With Traditional Suture Method in Rectal Anterior Resection Surgery With Specimen Extraction Via Stoma
Status: RECRUITING
Conditions: Ileostomy; Complications
Interventions: PROCEDURE: Suturing of ileostomy using "Dumpling suture method"|PROCEDURE: Suturing of ileostomy using Traditional suture method
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Does Less Trendelenburg Make a Difference in Robotic Assisted Gynecological Procedures?
Status: TERMINATED
Conditions: Benign Female Reproductive System Neoplasm
Interventions: PROCEDURE: Steep Trendelenburg|PROCEDURE: Decreased Trendelenburg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Closed-loop Insulin Therapy in Prepubertal Child in Free-life
Status: UNKNOWN
Conditions: Type 1 Diabetes Mellitus in Prepubertal Children
Interventions: DEVICE: Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions
Status: COMPLETED
Conditions: Anal Intraepithelial Neoplasia|High-grade Squamous Intraepithelial Lesion|HIV Infection
Interventions: DRUG: imiquimod|DRUG: fluorouracil|OTHER: questionnaire administration|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PVB vs Ketamine/Lidocaine in Rib Fracture Patients
Status: RECRUITING
Conditions: Rib Fractures|Rib Trauma|Rib Fracture Multiple|Pain, Acute
Interventions: COMBINATION_PRODUCT: lidocaine, ketamine intravenous infusion|DRUG: paravertebral block with ropivicaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bimanual Motor Skill Learning Through Robotics in Chronic Cerebellar Stroke Survivors and Healthy Individuals
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Cerebellar Stroke|Healthy Individuals (Controls)
Interventions: DEVICE: Bimanual motor skill learning with the REAplan® rehabilitation robot
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effects of Consumption of Pomegranate Juice on Carotid Intima-Media Thickness
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DRUG: PomWonderful Juice|DRUG: Placebo juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: PROBE Investigation of the Safety & Efficacy of Telmisartan (Micardis®) vs Ramipril (Altace®) Using ABPM in HTN
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Telmisartan|DRUG: Ramipril
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Variables That Are Correlated to Developing Multiple Endocrine Neoplasia (MEN) and Pancreatic Neuroendocrine Tumors (PNET)
Status: UNKNOWN
Conditions: Multiple Endocrine Neoplasia|Pancreatic Neuroendocrine Tumors|Hyperparathyroidism
Interventions: OTHER: Genome Sequencing|OTHER: Data Review
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation of the ShangRing vs. Mogen Clamp for Early Infant Male Circumcision (EIMC) in Sub-Saharan Africa
Status: COMPLETED
Conditions: Circumcision
Interventions: DEVICE: ShangRing|DEVICE: Mogen clamp
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Weekly Paclitaxel and Cisplatin to Treat Hormone Receptor Positive and Triple Negative Breast Cancer Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Tubular Breast Cancer|Mucinous Breast Cancer|Invasive Ductal Breast Cancer|Inflammatory Breast Cancer
Interventions: DRUG: Paclitaxel|DRUG: Cisplatin|DRUG: Gonadotropin-releasing hormone agonist|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single-Blind Study of a Single Dose of Peginterferon Lambda-1a Compared With Placebo in Outpatients With Mild COVID-19
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Peginterferon Lambda-1a|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools
Status: RECRUITING
Conditions: Obesity
Interventions: BEHAVIORAL: Diabetes Prevention Program Intensive Lifestyle Intervention plus stress management training|BEHAVIORAL: Diabetes Prevention Program Intensive Lifestyle Intervention plus general women's health topics
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tech-Enabled CM for AUD at Scale
Status: ACTIVE_NOT_RECRUITING
Conditions: Alcohol Use Disorder|Alcohol Dependence|Drug Dependence
Interventions: COMBINATION_PRODUCT: DynamiCare Motivation Support Program|OTHER: Untreated or Routine Care Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Controlled Trial On Clear Feeds Versus Low Residue Diet After Surgery In Elective Colorectal Surgery Patients
Status: COMPLETED
Conditions: Nausea/Vomiting
Interventions: DIETARY_SUPPLEMENT: Low Residue diet arm.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Informing Decisions in Chronic Critical Illness: A Randomized Control Trial (RCT)
Status: COMPLETED
Conditions: Chronic Critical Illness|Prolonged Mechanical Ventilation
Interventions: BEHAVIORAL: Supportive Information Team Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Topical Cyclosporine A for the Treatment of Dry Eye: A Randomized Clinical Study
Status: COMPLETED
Conditions: Dry Eye
Interventions: DRUG: Topical Cyclosporine A|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Leukemia|Myelodysplastic Syndrome
Interventions: PROCEDURE: Hematopoietic Cell Transplantation|RADIATION: Intensity-Modulated Radiation Therapy|RADIATION: Tomotherapy|RADIATION: Total-Body Irradiation|RADIATION: Volume Modulated Arc Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Utilizing Advance Care Planning Videos to Empower Perioperative Cancer Patients and Families
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: Advance care planning video|BEHAVIORAL: Control video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Clinical Trial Evaluating Efficacy and Safety of MC2-01 Cream
Status: COMPLETED
Conditions: Psoriasis Vulgaris
Interventions: DRUG: MC2-01 cream|DRUG: Cal/BDP combination|DRUG: Cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Drug Trial That Evaluates the Whitening Potential of Nicotine Gum
Status: COMPLETED
Conditions: Dental Pellicle
Interventions: DRUG: 2 mg nicotine gum|DRUG: 4 mg nicotine gum
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Safety and PK of MBX-400 (Cyclopropavir) in Normal Volunteers
Status: COMPLETED
Conditions: Cytomegalovirus Infection
Interventions: DRUG: MBX400|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Simulation-assisted Teaching in Learning Gastroscopy
Status: COMPLETED
Conditions: Endoscopy|Education|Gastroscopy|Esophagogastroduodenoscopy|Simulation
Interventions: OTHER: Simulation-based learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ghrelin Effect on Beta Cell Function in Health and Disease
Status: UNKNOWN
Conditions: Diabetes
Interventions: DRUG: Exendin (9-39)|DRUG: acyl ghrelin|DRUG: saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias
Status: TERMINATED
Conditions: Iron Overload|Sickle Cell Disease|Other Anemias
Interventions: DRUG: Deferiprone|DRUG: Deferoxamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Clinical Trial of ID93+GLA-SE Vaccine in BCG-vaccinated Healthy Adolescent
Status: UNKNOWN
Conditions: Tuberculosis
Interventions: BIOLOGICAL: Placebo|BIOLOGICAL: ID93+GLA-SE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Combination Therapy Amino Acid L-CARNITINE and Magnesium on Fatty Liver
Status: COMPLETED
Conditions: Fatty Liver, Nonalcoholic
Interventions: DIETARY_SUPPLEMENT: "SLIM WATER"|OTHER: Placebo - water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Safety and Efficacy of LIPO-202 for the Reduction of Central Abdominal Bulging Due to Subcutaneous Fat
Status: COMPLETED
Conditions: Central Abdominal Bulging
Interventions: DRUG: LIPO-202|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nasal Bridle Versus Nasal Patch for Fixation of Nasoenteral Feeding Tubes
Status: RECRUITING
Conditions: Feeding Tube Complication|Feeding Disorders
Interventions: DEVICE: Nasal bridle|OTHER: Nasal patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study of Efficacy and Safety of Pembrolizumab Plus Platinum-based Doublet Chemotherapy With or Without Canakinumab in Previously Untreated Locally Advanced or Metastatic Non-squamous and Squamous NSCLC Subjects
Status: ACTIVE_NOT_RECRUITING
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: canakinumab|DRUG: canakinumab matching placebo|DRUG: pembrolizumab|DRUG: carboplatin|DRUG: cisplatin|DRUG: paclitaxel|DRUG: nab-paclitaxel|DRUG: pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Positron Emission Tomography/Computed Tomography (PET/CT) Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Biodistribution, Safety and Tolerability and Diagnostic Performance of BAY86-4367 in Patients With Prostate Cancer and Healthy Volunteers
Status: TERMINATED
Conditions: Diagnostic Imaging
Interventions: DRUG: BAY86-4367|DRUG: BAY86-4367
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Itolizumab in Combination With Corticosteroids for the First-Line Treatment of Acute Graft Versus Host Disease (EQUATOR)
Status: RECRUITING
Conditions: Graft Versus Host Disease|GVHD|Acute-graft-versus-host Disease|Acute GVHD|aGVHD
Interventions: BIOLOGICAL: Itolizumab|DRUG: EQ001 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer
Status: COMPLETED
Conditions: Superficial Bladder Cancer
Interventions: PROCEDURE: Whole bladder laser light treatment as an alternative to radical cystectomy|DRUG: Photofrin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Lenalidomide (Revlimid) in Patients With Relapsed/Refractory Peripheral T-cell Lymphoma (PTCL) Patients
Status: TERMINATED
Conditions: Peripheral T-cell Lymphoma
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychosocial Treatment for Women With Depression and Pain
Status: COMPLETED
Conditions: Pelvic Pain|Depression
Interventions: BEHAVIORAL: Interpersonal Therapy for Pain (IPT-P)|BEHAVIORAL: Enhanced Support and Connection to Counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Database of Monochorionic Pregnancies
Status: RECRUITING
Conditions: Monochorionic Diamniotic Placenta|Monochorial Monoamniotic Placenta|Twin; Complicating Pregnancy|Twin to Twin Transfusion Syndrome|Twin Reversal Arterial Perfusion Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1 Study of the Safety and Immunogenicity of a Malaria Transmission-blocking Pfs25-Pfs25 Conjugate Vaccine
Status: WITHDRAWN
Conditions: Malaria|Malaria Vaccines|Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: Malaria Transmission-Blocking Pfs25-Pfs25 Conjugate Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Hip Arthroscopy; Femoral Nerve Block or Fascia Iliaca Block
Status: UNKNOWN
Conditions: Anlgesia for Hip Arthroscopy by Assessing Quality of Different Type of Regional Block, Femoral Nerve Block Versus Fascia Iliaca Block
Interventions: DRUG: Levobupivacaine|DRUG: Levobupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Parental Support Intervention For Our Children's Sake in Prisons in Sweden
Status: COMPLETED
Conditions: Parenting|Parent-Child Relations
Interventions: BEHAVIORAL: For Our Children's Sake|OTHER: Active control
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Prospective Study of Oncologic Outcomes After Laparoscopic Modified Complete Mesocolic Excision for Non-metastatic Right Colon Cancer [PIONEER Study]
Status: ENROLLING_BY_INVITATION
Conditions: Adenocarcinoma of the Colon
Interventions: PROCEDURE: Laparoscopic modified complete mesocolic excision
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p