pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Impact of Migraine on Work Productivity in Patients Treated With a Combination Product Containing Sumatriptan and Naproxen Sodium or Triptan Monotherapy
Status: COMPLETED
Conditions: Migraine Disorders
Interventions: DRUG: Combination therapy of sumatriptan and naproxen sodium (SumaRT/Nap)|DRUG: Triptan monotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: UNIty-Based MR-Linac Guided AdapTive RadiothErapy for High GraDe Glioma: A Phase 2 Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma Multiforme
Interventions: RADIATION: Reduced margin adaptive radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Randomized Trial of Early Versus Late Tracheostomy in Trauma Patients With Severe Brain Injury
Status: TERMINATED
Conditions: Respiratory Failure|Traumatic Brain Injury
Interventions: PROCEDURE: Early tracheostomy|PROCEDURE: Late tracheostomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)
Status: COMPLETED
Conditions: Chronic Idiopathic Constipation
Interventions: DRUG: Plecanatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Next Generation WATCHMAN LAA Closure Technology in Non-Valvular AF Patients (EVOLVE)
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: WATCHMAN LAA Closure Technology (Gen 4.0)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients
Status: COMPLETED
Conditions: Benign Paroxysmal Positional Vertigo
Interventions: DRUG: Meclizine|OTHER: Epley Maneuver|DRUG: Lorazepam|DRUG: Diphenhydramine|DRUG: Ondansetron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: BIOLOGICAL: Teplizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Percutaneous Transvenous Mitral Commissurotomy on The Left Atrial Appendage Function in Patients With Mitral Stenosis.
Status: NOT_YET_RECRUITING
Conditions: Mitral Stenosis
Interventions: DEVICE: Transesophageal echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Medication Metronome Project - Study to Facilitate Follow-up Testing Resulting From Prescribed Medications to Improve Patient Safety and Care
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension|Hyperlipidemia
Interventions: DEVICE: Medication Metronome|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetics of HSK7653 in Subjects With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: HSK7653 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment With Human Umbilical Cord Mesenchymal Stem Cells for Refractory Diabetic Peripheral Neuropathy
Status: UNKNOWN
Conditions: Diabetic Peripheral Neuropathy Type 2
Interventions: BIOLOGICAL: HUC-MSCs|BIOLOGICAL: Lipoic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Body Radiation Therapy With Boost Using Urethral-Sparing Intensity-Modulated Radiation Therapy Planning in Treating Patients With Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Stage I Prostate Adenocarcinoma|Stage II Prostate Adenocarcinoma
Interventions: RADIATION: Radiation Therapy Treatment Planning and Simulation|RADIATION: SBRT|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome
Status: COMPLETED
Conditions: Barth Syndrome
Interventions: DRUG: Elamipretide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring the Preventive Effect of Mitochondrial Protective Agent Idebenone on Post-stroke Epilepsy
Status: RECRUITING
Conditions: Post Stroke Epilepsy
Interventions: DRUG: idebenone 30 mg for 14 days|DRUG: idebenone 30 mg for 3 months
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MGMT-NET: O6-methylguanine-DNA Methyltransferase (MGMT) Status in Neuroendocrine Tumors: Predictive Factor of Response to Alkylating Agents
Status: COMPLETED
Conditions: Neuroendocrine Tumors
Interventions: DRUG: Oxaliplatin-based chemotherapy|DRUG: Alkylating-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing
Status: ACTIVE_NOT_RECRUITING
Conditions: Ventricular Arrythmia
Interventions: PROCEDURE: ommitence of defibrillation testing
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dabrafenib, Trametinib, and Spartalizumab for the Treatment of BRAF V600E or V600K Mutation Positive Stage IIIB/C/D Melanoma
Status: COMPLETED
Conditions: Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Interventions: DRUG: Dabrafenib|BIOLOGICAL: Spartalizumab|PROCEDURE: Therapeutic Conventional Surgery|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-acetylcysteine and NMDA Antagonist Interactions
Status: COMPLETED
Conditions: Cognitive Dysfunction
Interventions: DRUG: N-acetylcysteine and ketamine|DRUG: placebo and ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Proof of Concept Study to Investigate the Effect of a New Treatment in Patient With Chronic Pain
Status: COMPLETED
Conditions: Peripheral Neuropathies|Osteoarthritis
Interventions: BEHAVIORAL: Heat Pain Stimuli A|BEHAVIORAL: Heat Pain Stimuli B|BEHAVIORAL: Positive Video|BEHAVIORAL: Neutral Video|DRUG: Administration of T4P1001 capsules|DRUG: Administration of Placebo capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Immediate Effect of Dry Needling of the Lumbar Multifidus on Pain Sensitivity In A Healthy Population
Status: COMPLETED
Conditions: Low Back Pain
Interventions: OTHER: Trigger point dry needling|OTHER: Sham dry needling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study to Evaluate Revita DMR Post Market Pilot Clinical Follow-Up Registry in Patient With Type 2 Diabetes
Status: ENROLLING_BY_INVITATION
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Duodenal Mucosal Resurfacing (DMR)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment
Status: RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: ASTX727
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
Status: COMPLETED
Conditions: Cocaine Addiction|Cocaine-related Disorder|Executive Dysfunction
Interventions: DEVICE: transcranial Direct Current Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Gluten-free Diets on Anthropometric and Dietary Data of Healthy Eutrophic Women
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Gluten test food
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Delayed Cord Clamping in Infants Born by 'Two-step' Vaginal Delivery
Status: COMPLETED
Conditions: Placental Transfusion|Hematocrit Anemia
Interventions: PROCEDURE: Cord clamping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Vortioxetine for Treatment of Depressive Mood and Alcohol Use
Status: UNKNOWN
Conditions: Depressive Disorder, Major|Alcoholism
Interventions: DRUG: Vortioxetine|DRUG: Acamprosate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ADCLEC.syn1 in People With Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: BIOLOGICAL: ADCLEC.syn1 CAR T cells|DRUG: Conditioning chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Research Study of How Semaglutide Works in People With Disease Affecting the Heart and/or Blood Vessels and Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Semaglutide|DRUG: Placebo (semaglutide)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Rectus Sheath Block: Postoperative Analgesia and Proinflammatory Cytokines
Status: COMPLETED
Conditions: Postoperative Pain
Interventions: DRUG: Bupivacaine 0.25%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery
Status: COMPLETED
Conditions: Locally Advanced Bone Sarcoma|Locally Advanced Dedifferentiated Liposarcoma|Locally Advanced Gastrointestinal Stromal Tumor|Locally Advanced Soft Tissue Sarcoma|Metastatic Bone Sarcoma|Metastatic Liposarcoma|Metastatic Soft Tissue Sarcoma|Metastatic Undifferentiated Pleomorphic Sarcoma|Metastatic Unresectable Sarcoma|Pleomorphic Liposarcoma|Stage III Bone Sarcoma AJCC v7|Stage III Soft Tissue Sarcoma AJCC v7|Stage IV Bone Sarcoma AJCC v7|Stage IV Soft Tissue Sarcoma AJCC v7|Stage IVA Bone Sarcoma AJCC v7|Stage IVB Bone Sarcoma AJCC v7|Unresectable Bone Sarcoma|Unresectable Dedifferentiated Liposarcoma|Unresectable Liposarcoma|Unresectable Malignant Gastrointestinal Stromal Tumor|Unresectable Soft Tissue Sarcoma
Interventions: BIOLOGICAL: Ipilimumab|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With Metastases to the Liver or Lung
Status: WITHDRAWN
Conditions: Acinar Cell Adenocarcinoma of the Pancreas|Duct Cell Adenocarcinoma of the Pancreas|Liver Metastases|Lung Metastases|Recurrent Breast Cancer|Recurrent Pancreatic Cancer|Stage IV Breast Cancer|Stage IV Pancreatic Cancer
Interventions: PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging|OTHER: pharmacological study|BIOLOGICAL: tumor-homing peptide iRGD
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of VR and Accommdation Relax on Controlling Myopia in Children
Status: UNKNOWN
Conditions: Myopia|Accommodation Spasm|Children
Interventions: DEVICE: Virtual reality and accommodation relax techniques in combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Application of Citrate Dialysate in Chronic Haemodialysis
Status: COMPLETED
Conditions: Chronic Renal Disease
Interventions: DEVICE: Citrate dialysate (CiDi)|DEVICE: Standard dialysate (StDi)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: 177Lu-PSMA-617|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vytorin (10/20 Or 10/40) Compared to Atorvastatin (10 mg or 20 mg) in Patients With Coronary Artery Disease (0653A-126)(COMPLETED)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: simvastatin (+) ezetimibe|DRUG: Comparator: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
Status: UNKNOWN
Conditions: Transplantation Infection|Kidney Transplant; Complications|Stem Cell Transplant Complications|Liver Transplant; Complications|Microbial Colonization
Interventions: DIAGNOSTIC_TEST: Intestinal microbiome new generation sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of AWBAT™-D and MEPILEX® AG for Treatment of Donor Sites in Burn Surgery
Status: TERMINATED
Conditions: Burn Surgery
Interventions: DEVICE: AWBAT™-D and Mepilex® Ag dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Cytokines Profile in Aqueous Humor and Tear Before and After UCP Treatment
Status: RECRUITING
Conditions: Glaucoma|Ultrasound Cyclo Plasty|Aqueous Humor|Tear|Cytokines
Interventions: PROCEDURE: Ultrasound CycloPlasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Fibroblast Growth Factors 19 and 21 in Gestational Diabetes Mellitus
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: DIAGNOSTIC_TEST: biachemical detection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Locally Advanced Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Cadonilimab plus anlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Different Injection Speeds for Spinal Anaesthesia in Caesarean Section
Status: COMPLETED
Conditions: Pregnancy|Effects of; Anesthesia, Spinal and Epidural; in Pregnancy
Interventions: PROCEDURE: Slow Speed of spinal injection|PROCEDURE: Fast Speed of spinal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade
Status: RECRUITING
Conditions: Non Small Cell Lung Cancer|Metastatic Melanoma|Metastatic Renal Cell Carcinoma|Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: IL-2|DRUG: Pembrolizumab|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility of Systematic Handgrip Strength (HGS) Testing and Short-term Changes in Muscle Strength in Digestive Cancer Patients Treated by Chemotherapy
Status: COMPLETED
Conditions: Handgrip Strength Test|Sarcopenia|Digestive Cancer|Muscle Strength|Chemotherapy
Interventions: PROCEDURE: handgrip strength test|DRUG: chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Bronchiolitis Clearance Airways With Seaserum
Status: NOT_YET_RECRUITING
Conditions: Bronchiolitis Acute
Interventions: DEVICE: Physiomer|DEVICE: Saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Cancer
Interventions: DRUG: Erdafitinib|DRUG: Midazolam|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tamoxifen Resistance in Women With Stage I, Stage II, Stage IIIA, or Stage IIIB Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: tamoxifen citrate|GENETIC: gene expression analysis|GENETIC: protein expression analysis|OTHER: immunoenzyme technique|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: ADNEXMR Scoring System: Impact of an MR Scoring System on Therapeutic Strategy of Pelvic Adnexal Masses
Status: UNKNOWN
Conditions: Patient With Sonographically Indeterminate or Complex Adnexal Mass
Interventions: PROCEDURE: ADNEXMR Scoring System|OTHER: Standard strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: LegDeb2 Global Registry for Use of Legflow in Peripheral Arteries
Status: NOT_YET_RECRUITING
Conditions: Peripheral Arterial Disease|Superficial Femoral Artery Stenosis|Iliac Artery Stenosis|Arterial Occlusive Diseases|Popliteal Artery Stenosis|Critical Limb Ischemia
Interventions: DEVICE: Drug Coated Balloon
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: AN-PEP on Gluten Exposure in Celiacs
Status: COMPLETED
Conditions: Celiac Disease
Interventions: DRUG: Prolyl Endopeptidase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Omega-3 Fatty Acids in Adolescent Depression
Status: COMPLETED
Conditions: Adolescent Depression
Interventions: DRUG: Omega-3 Fatty Acids|DRUG: corn oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Inotuzumab Ozogamicin In Acute Lymphocytic Leukemia
Status: COMPLETED
Conditions: Acute Lymphocytic Leukemia
Interventions: DRUG: Inotuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Dosimetry of 68Ga-labelled OncoFAP Derivatives in Solid Tumors
Status: RECRUITING
Conditions: Breast Cancer|Colorectal Cancer|Oesophageal Cancer|Pancreas Adenocarcinoma
Interventions: DRUG: [68Ga]Ga-OncoFAP administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of Tacrolimus in Adults With Facial Non-segmental Vitiligo - VITAC
Status: COMPLETED
Conditions: Vitiligo
Interventions: DRUG: tacrolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Sentinel Lymph Node Biopsy in Patients With Breast Cancer After Neoadjuvant Therapy
Status: COMPLETED
Conditions: Breast Cancer
Interventions: PROCEDURE: Sentinel lymph node biopsy (SLNB)|PROCEDURE: Axillary dissection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: The Combination of Anti-PD-1 With Radiotherapy in Previously Untreated Metastatic Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: The combination of radiotherapy with anti-PD1 (pembrolizumab or nivolumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CaRe-ECMO Program on ECMO Weaning
Status: RECRUITING
Conditions: Critical Illness
Interventions: PROCEDURE: Cardiopulmonary rehabilitation|PROCEDURE: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of SBRT and GC4711 for Centrally Located or Large NSCLC
Status: TERMINATED
Conditions: SBRT|NSCLC|Non-metastatic
Interventions: DRUG: GC4711 +SBRT|DRUG: Placebo +SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Subcutaneous Injection Depot of Leuprolide Acetate in Patient With Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: leuprolide acetate FluidCrystal® injection depot|DRUG: leuprolide acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy
Status: COMPLETED
Conditions: Peripheral Neuropathy|Type 1 Diabetes
Interventions: DRUG: Salsalate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity
Status: WITHDRAWN
Conditions: SARS-CoV 2|COVID|COVID-19|Androgenetic Alopecia|Androgen Receptor Abnormal|Androgen Deficiency
Interventions: DIAGNOSTIC_TEST: CAG length <22|DIAGNOSTIC_TEST: CAG length >=22
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Radiation Therapy With or Without Antiandrogen Therapy in Treating Patients With Stage I or Stage II Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: flutamide|DRUG: Zoladex|DRUG: Lupron|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of Arhalofenate for Preventing Flares and Reducing Serum Uric Acid in Gout Patients
Status: COMPLETED
Conditions: Gout
Interventions: DRUG: Arhalofenate 600 mg|DRUG: Allopurinol 300 mg|DRUG: Colchicine 0.6 mg|DRUG: Placebo|DRUG: Arhalofenate 800 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Programmed Flexor-extensor Alternating Electrical Acupiont Stimulation on Limb Functional Reconstruction After Stroke
Status: COMPLETED
Conditions: Stroke Sequelae|Movement Disorders
Interventions: DEVICE: the fourth programmed generation of low-frequency acupoint electric stimulation therapy instrument|DEVICE: the fourth generation of low-frequency acupoint electric stimulation therapy instrument
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TCM Etiological Study on the Theory of XuSunShengJi in Liver Cirrhosis
Status: UNKNOWN
Conditions: Liver Cirrhosis
Interventions: DRUG: Fuzhenghuayu Tablet, Huangqi Decoction Granule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma
Status: UNKNOWN
Conditions: Melanoma (Skin)
Interventions: BIOLOGICAL: autologous dendritic cell-tumor fusion vaccine|BIOLOGICAL: gp100 antigen|BIOLOGICAL: therapeutic autologous dendritic cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Effects of GW876008 on Brain Activation During Emotional Processing in Healthy Subjects.
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: placebo|DRUG: lorazepam|DRUG: GW876008
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: DIAGNOSTIC
Clinical trial: Outcome of Rehabilitation Following Internally Fixed Ankle Fractures
Status: UNKNOWN
Conditions: Ankle Fractures|Fracture
Interventions: DEVICE: Aircast XP Walker boot|DEVICE: Plaster Immobilisation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-arm Clinical Study of HAIC Combined With Apatinib and Camrelizumab in the Treatment of Unresectable MTM HCC
Status: RECRUITING
Conditions: Macrotrabecular Massive Hepatocellular Carcinoma
Interventions: PROCEDURE: HAIC|DRUG: Camrelizumab plus Apatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Surgery With or Without Chemotherapy in Treating Patients With Stage II or Stage III Cancer of the Esophagus
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: DRUG: cisplatin|DRUG: fluorouracil|PROCEDURE: conventional surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Comparison of the I-gel, Supreme and Proseal LMA in Paralyzed Patients
Status: COMPLETED
Conditions: Airway Complication of Anaesthesia
Interventions: DEVICE: PROSEAL LMA|DEVICE: SUPREMA LMA|DEVICE: I-GEL LMA
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of High Fruit, Vegetable, and Dairy Intake on Plasma Lipids and Blood Pressure in Healthy Individuals
Status: COMPLETED
Conditions: Cardiovascular Disease|Dyslipidemia|Blood Pressure
Interventions: OTHER: Dietary Intervention|OTHER: Dietary Intervention|OTHER: Dietary Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Tailored Preventive Program on Caires Incidence Using International Caries Classification and Management System (ICCMS) A Randomized Clinical Trial
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: tailored preventive program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Symptom-driven Maintenance and Reliever Treatment to Prevent Exacerbations in COPD
Status: UNKNOWN
Conditions: COPD
Interventions: DRUG: Spiromax Budesonide/formoterol|DRUG: Diskus Fluticasone/salmeterol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TIVA vs Inhalational Mode of Anaesthesia
Status: COMPLETED
Conditions: Anesthesia Awareness
Interventions: DRUG: Injection dexmedetomidine|DRUG: Injection, Propofol, 10 Mg|OTHER: sevoflurane|OTHER: nitrous oxide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: TNF-alpha Antagonists for AECOPD: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial
Status: COMPLETED
Conditions: COPD Exacerbation
Interventions: DRUG: Prednisone|DRUG: Etanercept|DRUG: levofloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study
Status: COMPLETED
Conditions: Nephrosis, Lipoid
Interventions: DRUG: Myfortic plus low-dose steroid|DRUG: Prednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DBS of the MLR for Gait and Balance Disorders in PD Patients
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DEVICE: Deep brain stimulation|DEVICE: Sham stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Efficacy, Safety and Tolerability of Bupropion Hydrochloride Extended-release Tablet, and Escitalopram Oxalate Capsule in Subjects With Major Depressive Disorder
Status: COMPLETED
Conditions: Depressive Disorder, Major
Interventions: DRUG: Bupropion|DRUG: Bupropion Matching Placebo|DRUG: Escitalopram|DRUG: Escitalopram Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Exercise Prehabilitation Intervention for Improving Mobility and Recovery Outcomes in Patients Undergoing Head and Neck Cancer Surgery
Status: RECRUITING
Conditions: Head and Neck Carcinoma
Interventions: OTHER: Electronic Health Record Review|OTHER: Exercise Intervention|OTHER: Medical Device Usage and Evaluation|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety of Dapagliflozin in Children With Proteinuric Chronic Kidney Disease
Status: WITHDRAWN
Conditions: Proteinuria|Chronic Kidney Diseases
Interventions: DRUG: ACEI treatment|DRUG: Dapagliflozin+ACEI treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study in HFpEF Patients to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium
Status: TERMINATED
Conditions: Heart Failure
Interventions: DRUG: AZD9977|DRUG: Spironolactone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rapid Antidepressant Effects of Leucine
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DRUG: L-Leucine|OTHER: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Mantle Cell Lymphoma|Follicular Lymphoma|Richter Transformation Lymphoma
Interventions: BIOLOGICAL: Zilovertamab vedotin|DRUG: Nemtabrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparative Phase 3 Trial to Assess the Safety and Efficacy of Triple-chamber Parenteral Nutrition Formulation
Status: COMPLETED
Conditions: Nutrition Support
Interventions: OTHER: Oliclinomel N4|OTHER: Compounded ternary parenteral nutrition admixtures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Anti-EGFR Antibody-drug Conjugate (ADC) Combine With CDK4/6 Inhibitors Posterior Line in the Treatment of Recurrent/Metastatic CDKN2A Gene Variant Head and Neck Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: MRG003 combined with Dalpicicilip
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prostate Cancer Screening and Dietary Heterocyclic Amines in African American Men
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: OTHER: physiologic testing|OTHER: study of socioeconomic and demographic variables|PROCEDURE: evaluation of cancer risk factors|PROCEDURE: mutation carrier screening|PROCEDURE: study of high risk factors
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: SCREENING
Clinical trial: Single Ascending Dose Study of NRS 033 in Healthy Volunteers
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: DRUG: NRS-033|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Restylane Defyne in a Stepwise Treatment Approach
Status: COMPLETED
Conditions: Lower Face Folds and Lines
Interventions: DEVICE: Restylane Defyne|DEVICE: Restylane Defyne
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Prognostic Value of the Suppression Ratio Evaluated by BIS Among Patients Admitted to the ICU for Cardiac Arrest
Status: UNKNOWN
Conditions: Cardiac Arrest
Interventions: DEVICE: Aspect BIS XP (A-2000) Bispectral Index Patient Monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Subcutaneous Nerve Stimulation for Failed Back Surgery Syndrome (FBSS) Patients
Status: TERMINATED
Conditions: Failed Back Surgery Syndrome|Post-laminectomy Syndrome
Interventions: DEVICE: PrimeAdvanced® neurostimulator system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Pharmacokinetic Drug Interaction After Oral Concurrent Administration of Fimasartan and Amlodipine in Healthy Male Volunteers
Status: COMPLETED
Conditions: Essential Hypertension
Interventions: DRUG: Fimasartan|DRUG: Amlodipine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Efficacy of Probiotics on Physical Performance
Status: COMPLETED
Conditions: Physical Performance
Interventions: DIETARY_SUPPLEMENT: Probiotic supplement|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Nordic 8 - A Phase II Trial
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab|DRUG: Irinotecan|DRUG: Oxaliplatin|DRUG: Folinic Acid|DRUG: Calcium Carbonate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Exercise in Pediatric Hemophilia
Status: UNKNOWN
Conditions: Hemophilia A, Severe|Hemophilia Arthropathy
Interventions: OTHER: Traditional exercise training|OTHER: Specific exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Continuous Combined Hormone Replacement Therapy and Clodronate on Bone Mineral Density (BMD) in Osteoporotic Women
Status: COMPLETED
Conditions: Osteoporosis
Interventions: DRUG: Klodronate and Kliogest|PROCEDURE: Placebo+ Kliogest|DRUG: Bonefos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial Using Combination Irinotecan and Thalidomide for Recurrent CNS Tumors
Status: COMPLETED
Conditions: Brain and Nervous System|Cancer
Interventions: DRUG: Irinotecan|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lucitanib (E3810) in Patients With Advanced Cancer and FGFR, VEGFR, or PDGFR Pathway Aberrations
Status: WITHDRAWN
Conditions: Advanced Cancer
Interventions: DRUG: Lucitanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: DRUG: Apocynin and placebo nebulization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Remote Ischemic Preconditioning (RIPC) on Blood Pressure and Its Vascular Protection Effect
Status: UNKNOWN
Conditions: Pressure; Brachial Plexus
Interventions: PROCEDURE: RIPC|PROCEDURE: Sham RIPC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Development of Adherence Biomarkers for Multiple Microbicide and Multipurpose Prevention Technology (MPT) Dosage Forms
Status: COMPLETED
Conditions: HIV
Interventions: OTHER: HEC Placebo gel|OTHER: Placebo Intravaginal Ring|OTHER: Placebo Vaginal Film|OTHER: Placebo Vaginal Insert
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Comparative Effects of SWT and Maitland LM in Mechanical LBP
Status: UNKNOWN
Conditions: Mechanical Low Back Pain
Interventions: DEVICE: Shockwave Therapy|OTHER: Maitland's lumbar mobilizations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY8888AX in Participants Using a Connected Insulin Management Platform
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 1 Diabetes|Type 2 Diabetes|Type 2 Diabetes Treated With Insulin
Interventions: DRUG: Insulin Lispro|DEVICE: Tempo Smart Button|DEVICE: Dexcom G6 CGM|DEVICE: Glooko Research Medical App (RMA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab,Zanubrutinib in Combination With Lenalidomide, Followed by Zanubrutinib or Lenalidomide Maintenance in Patients With Primary or Secondary CNS Lymphoma
Status: RECRUITING
Conditions: Central Nervous System Lymphoma
Interventions: DRUG: Rituximab, Lenalidomide, Zanubrutinib|DRUG: Lenalidomide, Zanubrutinib|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1b/2 Study of Rebastinib (DCC-2036) in Combination With Paclitaxel in Patients With Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Locally Advanced or Metastatic Solid Tumor
Interventions: DRUG: rebastinib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transplantation of Deceased Donors With COVID-19 Into COVID-19 Negative Recipients Utilizing Casirivimab and Imdevimab Antibody Cocktail
Status: WITHDRAWN
Conditions: COVID-19|Organ Transplant
Interventions: DRUG: Casirivimab and Imdevimab Antibody Cocktail
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: 3D Craniofacial Morphologic Development of Healthy Infants
Status: COMPLETED
Conditions: Development, Infant|IMAGE|Craniofacial Asymmetry|Plagiocephaly
Interventions: OTHER: three dimensional photography using a 3dMDHead System (3dMD, Atlanta, GA, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Remote Ischemic Conditioning for Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage
Status: UNKNOWN
Conditions: Intracerebral Hemorrhage Lobar|Cerebral Amyloid Angiopathy
Interventions: DEVICE: Remote ischemic conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Atorvastatin as an Adjunct to DFDBA in Intrabony Defects
Status: COMPLETED
Conditions: Chronic Periaortitis|Intrabony Periodontal Defect
Interventions: BIOLOGICAL: DFDBA|DRUG: DFDBA with atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Muscle Function and Muscle Ultrasound in ICU
Status: RECRUITING
Conditions: Muscle Weakness
Interventions: DIAGNOSTIC_TEST: Ultrasound|DIAGNOSTIC_TEST: Dynamometric muscular assessment|DIAGNOSTIC_TEST: Manual muscular Assessment (MRC-SS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Single Ascending Doses of STAR-101 in Healthy Participants
Status: WITHDRAWN
Conditions: Healthy Volunteers
Interventions: DRUG: Star-101|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Investigation of Cortico-Rectal Pathways in Healthy Subjects and Constipated Patients
Status: UNKNOWN
Conditions: Healthy Volunteers|Constipation
Interventions: PROCEDURE: Cortical Evoked Potentials|PROCEDURE: Transcranial motor evoked potentials|PROCEDURE: Translumbosacral motor evoked potentials
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Shuiniujiao Dihuang Decoction With Variation for the Treatment of Psoriasis
Status: NOT_YET_RECRUITING
Conditions: Psoriasis Vulgaris
Interventions: DRUG: SDD formula|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of CMV/EBV-CMI in Haploid HSCT
Status: RECRUITING
Conditions: Hematopoietic Stem Cell Transplantation|Cytomegalovirus Infections|Epstein-Barr Virus Infections
Interventions: DIAGNOSTIC_TEST: CMV/EBV-CMI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluation Perioperative Nutrition on Donor Site Healing in Patients Undergoing Reconstructive Burn Surg
Status: TERMINATED
Conditions: Burn|Reconstructive Surgical Procedure
Interventions: DIETARY_SUPPLEMENT: Juven (Ross Products) protein supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Study to Evaluate the Efficacy and Safety of Givinostat in Ambulant Patients With Duchenne Muscular Dystrophy
Status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: givinostat|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Total Knee Arthroplasty
Status: COMPLETED
Conditions: Postoperative Pain|Knee Arthroplasty
Interventions: PROCEDURE: Adductor-Canal-Blockade with Ropivacaine|PROCEDURE: Adductor-Canal-blockade with saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pain, Physical Activity, Posture and Quality of Life in Post-COVID-19 Individuals With Idiopathic Scoliosis
Status: RECRUITING
Conditions: COVID-19 Respiratory Infection|Idiopathic Scoliosis
Interventions: OTHER: Physical Evaluations of post-COVID-19 individuals|OTHER: Physical evaluations of non-post-COVID-19 individuals
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility and Preliminary Efficacy of Support Figure Attendance at Bariatric Patients' Clinical Visits
Status: COMPLETED
Conditions: Obesity, Morbid|Bariatric Surgery Candidate|Diet Habit|Behavior, Social|Physical Activity
Interventions: BEHAVIORAL: Attendance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT