pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Satralizumab in the Treatment of Pulmonary Arterial Hypertension (SATISFY-JP Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulmonary Arterial Hypertension
Interventions: DRUG: Satralizumab (Genetical Recombination)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodontal Wound Healing With CHX and Hyaluronic Acid
Status: COMPLETED
Conditions: Surgical Flaps|Wound Healing|Gingiva
Interventions: DEVICE: CHX|DEVICE: CHX+HA+ADS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Steroids Added to Dithranol and Narrow Band UVB(Ultraviolet B) (UVBnb) in Psoriasis
Status: WITHDRAWN
Conditions: Psoriasis
Interventions: DRUG: Steroid active treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bemarituzumab Monotherapy and Combination With Other Anti-cancer Therapy in SqNSCLC With FGFR2b Overexpression (FORTITUDE-201)
Status: COMPLETED
Conditions: Squamous-Cell Non-Small-Cell Lung Cancer
Interventions: DRUG: Bemarituzumab|DRUG: Docetaxel|DRUG: Pembrolizumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Nab-paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Myelodysplastic Syndrome
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Chest Computed Tomography|PROCEDURE: Echocardiography|PROCEDURE: Hematopoietic Cell Transplantation|DRUG: Methotrexate|PROCEDURE: Multigated Acquisition Scan|DRUG: Ruxolitinib Phosphate|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Crossover Comparison of Tidal Volume Delivery During Nasal Intermittent Positive Pressure Ventilation in Preterm Infants: Infant Cannula vs. Nasal Continuous Positive Airway Pressure Prongs
Status: UNKNOWN
Conditions: Respiratory Distress Syndrome in Premature Infant
Interventions: DEVICE: Nasal interface
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Metastatic Lung Non-Small Cell Carcinoma|Metastatic Malignant Neoplasm in the Brain|Stage IV Lung Cancer AJCC v8
Interventions: PROCEDURE: Biospecimen Collection|BIOLOGICAL: Cemiplimab|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Elastography|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase (Ph) II Bevacizumab + Erlotinib for Patients (Pts) With Recurrent Malignant Glioma (MG)
Status: COMPLETED
Conditions: Glioblastoma|Gliosarcoma
Interventions: DRUG: Bevacizumab and Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Cross-over Clinical Trial to Evaluate the Use of Oral Health-Related Quality of Life in Dental Practice
Status: COMPLETED
Conditions: Oral Health|Quality of Life
Interventions: OTHER: Dental consultation using OHIP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma
Status: COMPLETED
Conditions: Leukemia|Lymphoma
Interventions: DRUG: Propofol-Fentanyl|DRUG: Propofol alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Vascana® in Subjects With Secondary Raynaud's Phenomenon
Status: COMPLETED
Conditions: Raynaud's Phenomenon Secondary to Connective Tissue Disease
Interventions: DRUG: Vascana (0.9% nitroglycerin cream)|DRUG: Vehicle Cream (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Treatment of Cancer With Immune Checkpoint Inhibition Therapy Boosted by High Intensity Focused Ultrasound Histotripsy
Status: RECRUITING
Conditions: Cancer|Metastatic Cancer
Interventions: DEVICE: HIFU-HT|DRUG: ICI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease
Interventions: DEVICE: Torax Medical, Inc. LINX Reflux Management System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: RP II Study of SOX vs mFOLFOX6 in Patients With Resectable Rectal Cancer (KSCC1301).
Status: UNKNOWN
Conditions: Rectal Cancer
Interventions: OTHER: Laboratory test|OTHER: Medical history and physical examination|OTHER: BW and height|OTHER: Performance status|OTHER: Creatinine clearance|OTHER: Biomarker|RADIATION: Contrasting CT|OTHER: Adverse event|OTHER: HBs antigen and HCV antibody|OTHER: Endoscopy|OTHER: HBs antibody and HBc antibody|DRUG: S-1|DRUG: L-OHP (130mg/m2)|DRUG: L-OHP (85 mg/m2)|DRUG: l-LV|DRUG: 5-FU
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non-Invasive Measurement of Cardiac Output and Stroke Volume in PE
Status: ENROLLING_BY_INVITATION
Conditions: Pulmonary Embolism|Pulmonary Embolus/Emboli|Pulmonary Disease|Pulmonary Embolism and Thrombosis|Pulmonary Embolism Subacute Massive|Pulmonary Embolism Acute Massive
Interventions: DEVICE: Non-invasive hemodynamic measurements
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease.
Status: COMPLETED
Conditions: Dry Eye Disease
Interventions: DRUG: OTX-CSI|OTHER: Placebo Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Lidocaine and Ketorolac for Pain Management
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Lidocaine|DRUG: Ketorolac Tromethamine|DRUG: Normal Saline Drip|DRUG: Normal Saline Push
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study on the Treatment of Prurigo Nodularis With Stapokibart Injection
Status: NOT_YET_RECRUITING
Conditions: Prurigo Nodularis
Interventions: BIOLOGICAL: Stapokibart|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TID 1000 mg Mesalazine Versus TID 2x500 mg Mesalazine in Active Ulcerative Colitis (UC)
Status: COMPLETED
Conditions: Active Ulcerative Colitis
Interventions: DRUG: Mesalazine - TID 1000 mg|DRUG: Mesalazine - TID 2x 500 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison Trial of Letrozole to Anastrozole in the Adjuvant Treatment of Postmenopausal Women With Hormone Receptor and Node Positive Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Letrozole|DRUG: Anastrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadj Admin Autologous Tumor Infiltrating Lymphocytes & Pembrolizumab for Treatment of Adv Melanoma Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Melanoma|Pathologic Stage IIIB Cutaneous Melanoma AJCC v8|Pathologic Stage IIIC Cutaneous Melanoma AJCC v8|Pathologic Stage IIID Cutaneous Melanoma AJCC v8|Stage IV Melanoma
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|BIOLOGICAL: Lifileucel|BIOLOGICAL: Pembrolizumab|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Different Degrees of Renal Impairment on the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of BIBT 986 BS in Subjects With Normal Renal Function and Patients With Different Degrees of Renal Impairment
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BIBT 986 BS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Explore the Feasibility of Dynamic Changes of TCR Diversity in Peripheral Blood in Monitoring Recurrence and Evaluating Prognosis of Epithelial Ovarian Cancer
Status: NOT_YET_RECRUITING
Conditions: Epithelial Ovarian Cancer|Stage III Ovarian Cancer|Stage IV Ovarian Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Atorvastatin Administration Before Primary Percutaneous Coronary Intervention
Status: COMPLETED
Conditions: Angioplasty, Transluminal, Percutaneous Coronary
Interventions: DRUG: atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes Following Omission of Daily Routine Chest Radiographs Following Pulmonary Resection
Status: COMPLETED
Conditions: Lung Cancer|Lung Diseases|Lung Cancer, Nonsmall Cell|Surgery|Lung Adenocarcinoma
Interventions: DIAGNOSTIC_TEST: Chest Xray|DIAGNOSTIC_TEST: No daily chest xray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prophylactic Cranial Irradiation in Erlotinib/Gefitinib-responders With Non-small Cell Lung Cancer (NSCLC) (RT1001)
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: RADIATION: Prophylactic cranial irradiation|DRUG: Erlotinib /Gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Expressive Writing in Improving the Wellbeing or Comforting Capacity of Caregivers of Patients With Cancer
Status: COMPLETED
Conditions: Caregiver
Interventions: OTHER: Psychosocial Support for Caregiver|OTHER: Psychosocial Support for Caregiver|OTHER: Questionnaire Administration|OTHER: Sham Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Evaluate the Efficacy and Safety of Rosnilimab (ANB030) in Treatment of Subjects With Moderate-to-Severe Alopecia Areata
Status: UNKNOWN
Conditions: Alopecia Areata
Interventions: BIOLOGICAL: Rosnilimab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Belimumab Impact on a BLyS Activity Signature Test in the Absence of Confounding Polypharmacy
Status: UNKNOWN
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: belimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer
Status: UNKNOWN
Conditions: Lymphedema|Stage IA Cervical Cancer|Stage IA Uterine Corpus Cancer|Stage IA Vulvar Cancer|Stage IB Cervical Cancer|Stage IB Uterine Corpus Cancer|Stage IB Vulvar Cancer|Stage II Uterine Corpus Cancer|Stage II Vulvar Cancer|Stage IIA Cervical Cancer|Stage IIIA Vulvar Cancer|Stage IIIB Vulvar Cancer|Stage IIIC Vulvar Cancer|Stage IVB Vulvar Cancer
Interventions: OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Study of High Risk Factors|PROCEDURE: Therapeutic Conventional Surgery|PROCEDURE: Therapeutic Laparoscopic Surgery|PROCEDURE: Therapeutic Lymphadenectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Operative or Conservative Treatment for Subacromial Impingement Syndrome?
Status: ACTIVE_NOT_RECRUITING
Conditions: Subacromial Impingement Syndrome
Interventions: PROCEDURE: Arthroscopic acromioplasty or arthroscopy alone (sham) or conservative treatment (rehabilitation)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation
Status: NOT_YET_RECRUITING
Conditions: HIV Infections|Substance Use Disorders|Addiction|Opioid Use|Drug Use|Intravenous Drug Usage
Interventions: BEHAVIORAL: Peer-educator-based network
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: TMS of Visual Working Memory
Status: WITHDRAWN
Conditions: Occipital Transcranial Magnetic Stimulation
Interventions: DEVICE: Sham TMS condition|DEVICE: OffLine TMS Condition|DEVICE: Online TMS condition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single Versus Dual Implant Fixation of Distal Femur Fractures
Status: NOT_YET_RECRUITING
Conditions: Articular Fractures
Interventions: PROCEDURE: Single Implant Fixation|PROCEDURE: Dual Implant Fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia
Status: COMPLETED
Conditions: Plasmodium Falciparum|Malaria|Uncomplicated Malaria
Interventions: DRUG: Amodiaquine-artesunate (ASAQ)|DRUG: Artemether+Lumefantrine (AL)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: How is COGNItive Function Affected by Cardiac Resynchronisation Therapy?
Status: SUSPENDED
Conditions: Cognitive Impairment|Cognitive Change|Heart Failure, Systolic|Heart Failure|Cognitive Impairment, Mild|Left Ventricular Dysfunction|Left Ventricular Systolic Dysfunction|Systolic Dysfunction|Systolic Heart Failure
Interventions: DIAGNOSTIC_TEST: Repeatable Assessment of Neuropsychological Status|DIAGNOSTIC_TEST: Hospital Anxiety and Depression Scale|DIAGNOSTIC_TEST: Frontal Assessment Battery|DIAGNOSTIC_TEST: Trail Making Test Part A and B|DIAGNOSTIC_TEST: Test of Premorbid Functioning
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of JS002 as Monotherapy in Patients With Primary Hypercholesterolaemia and Mixed Dyslipidemia
Status: NOT_YET_RECRUITING
Conditions: Primary Hypercholesterolaemia and Mixed Dyslipidemia
Interventions: DRUG: JS002|DRUG: JS002|DRUG: Placebo|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short-course Radiotherapy Combined With Sintilimab for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: sintilimab，programmed death 1 monoclonal antibody
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Aflibercept Versus Placebo With FOLFIRI in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin Chemotherapy
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Aflibercept|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib Plus Letrozole Treatment After Progression to Second Line Chemotherapy for Women With ER/PR-positive Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Cancer
Interventions: DRUG: Palbociclib 125mg|DRUG: Letrozole 2.5mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: BioImpedentiometry, Lung UltraSound and cONgestion in Heart Failure
Status: COMPLETED
Conditions: Congestive Heart Failure
Interventions: OTHER: Deuterium oxide dilution|OTHER: Bioimpedentiometry|OTHER: Lung and subcutaneous ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Are Sutures Required for Vaginal Hysterectomy: A Randomized Controlled Trial
Status: UNKNOWN
Conditions: Vaginal Hysterectomy
Interventions: PROCEDURE: Performing Vaginal hysterectomy with Harmonic Scalpel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Gemcitabine and Capecitabine for Treatment Resistant, Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Gemcitabine + Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and M7824 in Treating Patients With Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer
Status: COMPLETED
Conditions: Anatomic Stage IV Breast Cancer AJCC v8|Metastatic Breast Carcinoma|Prognostic Stage IV Breast Cancer AJCC v8
Interventions: DRUG: Bintrafusp Alfa|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Maintenance of Anaesthesia With Sevoflurane Versus Propofol and the Occurrence of Postoperative Headache.
Status: UNKNOWN
Conditions: Headache
Interventions: DRUG: Propofol|DRUG: Sevoflurane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Camrelizumab in Combination With Chemotherapy or Apatinib Mesylate as First-Line Treatment for R/M HNSCC
Status: RECRUITING
Conditions: Recurrent Head and Neck Squamous Cell Carcinoma|Metastatic Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Camrelizumab|DRUG: Cisplatin|DRUG: Docetaxel|DRUG: Apatinib Mesylate|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DD T2 Daily Disposable Registration Trial
Status: COMPLETED
Conditions: Myopia|Refractive Errors
Interventions: DEVICE: verofilcon A contact lenses|DEVICE: delefilcon A contact lenses
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty
Status: COMPLETED
Conditions: Knee Arthropathy
Interventions: DRUG: Tranexamic Acid|DRUG: Fibrin glue|BIOLOGICAL: Fibrin glue|OTHER: Habitual haemostasis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Psychobiological Mechanisms Underlying Chronic Pain
Status: COMPLETED
Conditions: Fibromyalgia|Pain, Chronic|Chronic Pain, Widespread
Interventions: DRUG: Bromocriptine Mesylate Capsules|DRUG: Amisulpride 400 MG|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy of VR Based Sword Fighting Exercises to Improve Upper Body Movements in Hemiplegic Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Hemiplegic Gait
Interventions: BEHAVIORAL: Virtual reality based exercises|OTHER: standard physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Neoadjuvant GTX With Chemoradiation for Pancreatic Cancer (Stage II/III)
Status: UNKNOWN
Conditions: Pancreatic Cancer Stage II|Pancreatic Cancer Stage III
Interventions: DRUG: Neoadjuvant gemcitabine, capecitabine, and docetaxel|DRUG: Gemcitabine, capecitabine, docetaxel followed by radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Veno-arterial Extracorporeal Membrane Oxygenation Prior to Left Ventricular Assist Device Implantation.
Status: UNKNOWN
Conditions: Cardiogenic Shock|Heart Failure|Extracorporeal Membrane Oxygenation|Left Ventricular Assist Device
Interventions: DEVICE: Left Ventricular Assist Device Implantation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of PMK-S005 in the Prevention of Recurrent Peptic Ulcer in Low-dose Aspirin Users
Status: COMPLETED
Conditions: Peptic Ulcer
Interventions: DRUG: Placebo|DRUG: PMK-S005 1|DRUG: PMK-S005 2|DRUG: PMK-S005 3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Effectiveness of Kuvan in Amish PKU Patients
Status: COMPLETED
Conditions: Phenylketonuria
Interventions: DRUG: saproterin dihydrochloride|OTHER: Diet treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Closed Sinus Tenting Using Densah Burs Osteotomy Versus Conventional Osteotomy in Localized Pneumatization
Status: UNKNOWN
Conditions: Edentulous Alveolar Ridge
Interventions: PROCEDURE: Use of Densah Burs in closed sinus lift|PROCEDURE: Closed sinus lift using osteotomes
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer
Status: NOT_YET_RECRUITING
Conditions: Bladder Cancer
Interventions: DRUG: Intravenous ascorbic acid/vitamin C
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Citicoline as Neuroprotector in Preterm
Status: RECRUITING
Conditions: Pre-Term
Interventions: DRUG: Citicoline|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Early Diagnosis of Native and Device-associated Meningitis
Status: UNKNOWN
Conditions: Bacterial Meningitis|Fungal Meningitis|Implant Infection
Interventions: DIAGNOSTIC_TEST: D-lactate test|DIAGNOSTIC_TEST: Standard diagnostic tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Distalization Using Infrazygomatic Crest Miniscrews and Zygomatic Miniplates: A Randomized Clinical Trial
Status: UNKNOWN
Conditions: Class II Division 1 Malocclusion
Interventions: DEVICE: infrazygomatic miniscrew|DEVICE: zygomatic miniplate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Side Effects Screening and Early Intervention to Impact in Quality of Life of Gynaecological Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Quality of Life|Gynaecological Cancer|Lymphedema, Lower Limb|Sexual Dysfunction
Interventions: DIAGNOSTIC_TEST: systematic screening and early treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: The Effect of Chia Seeds on HDL Cholesterol
Status: COMPLETED
Conditions: Diet|Habits
Interventions: DIETARY_SUPPLEMENT: Chia Seeds and instant oatmeal breakfast|DIETARY_SUPPLEMENT: Cheerio Breakfast|DIETARY_SUPPLEMENT: Instant Oatmeal breakfast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Artificial Intelligence-assisted Diagnosis and Prognostication in Low Ejection Fraction Using Electrocardiograms
Status: RECRUITING
Conditions: Left Ventricular Systolic Dysfunction (Disorder)
Interventions: OTHER: AI-enabled ECG-based Screening Tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Effect of Hibiscus Tea and Green Tea Supplements on Athletic Performance, Blood Pressure, Muscle Damage Indices and Oxidative Stress
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Hibiscus tea|DIETARY_SUPPLEMENT: green tea|DIETARY_SUPPLEMENT: placebo (dextrose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Motor Learning in Dysphagia Rehabilitation
Status: TERMINATED
Conditions: Dysphagia|Swallowing Disorders|Deglutition Disorders|Stroke
Interventions: BEHAVIORAL: Biofeedback|DEVICE: Transcranial Direct Current Stimulation|BEHAVIORAL: Financial Reward|BEHAVIORAL: targeted dysphagia training maneuver|RADIATION: Videofluoroscopy (VF) and Barium|DEVICE: Transcranial Magnetic Stimulation|DEVICE: Submental Electromyography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Neoadjuvant in Inflammatory Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer
Interventions: DRUG: Lapatinib|DRUG: Paclitaxel|DRUG: 5-Fluorouracil (5-FU)|DRUG: Epirubicin|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2008
Status: UNKNOWN
Conditions: Childhood Acute Lymphoblastic Leukemia
Interventions: DRUG: PEG-L-asparaginase ind|DRUG: PEG-L-asparaginase cons|DRUG: E.coli L-asparaginase|DRUG: High-dose Methotrexate|DRUG: Low-dose Methotrexate|DRUG: Triple intrathecal therapy|RADIATION: Cranial irradiation|DRUG: Daunorubicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TRANSLINK: Defining the Role of Xeno-directed and Immune Events (SVD) in Patients Receiving Animal-derived Bioprosthetic Heart Valves
Status: COMPLETED
Conditions: Patients Receiving Animal-derived Bioprosthetic Heart Valves
Interventions: DEVICE: Patients receiving animal-derived bioprosthetic heart valves.|OTHER: Echocardiography (1)|OTHER: Echocardiography (2)|OTHER: Echocardiography (3)|BIOLOGICAL: Blood sample (1)|BIOLOGICAL: Blood sample (2)|BIOLOGICAL: Blood sample (3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cognitive Training in Parkinson's Disease, the iPARK Study
Status: UNKNOWN
Conditions: Parkinson Disease|Cognitive Impairment
Interventions: BEHAVIORAL: Working memory updating training|BEHAVIORAL: Placebo training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Trial of Lornoxicam to Diclofenac in Patients of Osteoarthritis of Knee Joint.
Status: COMPLETED
Conditions: Osteoarthritis of Knee Joint
Interventions: DRUG: Diclofenac|DRUG: Lornoxicam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bile Acids in Acute Insulin Resistance
Status: RECRUITING
Conditions: PI3K Gene Mutation|AKT Gene Mutation|MTOR Gene Mutation|Cancer|Insulin Resistance
Interventions: DRUG: Drug-induced acute insulin resistance due to PI3K inhibitor, AKT inhibitor, or mTOR inhibitor
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Epidural Anesthesia With Chloroprocaine Versus Lidocaine
Status: COMPLETED
Conditions: Anesthesia
Interventions: DRUG: Chloroprocaine|DRUG: Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Status: RECRUITING
Conditions: Dravet Syndrome
Interventions: DRUG: EPX-100 (clemizole HCl)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Analgesic Requirements for the ProSeal Laryngeal Mask Airway Versus the Tracheal Tube in Females Undergoing Gynecological Laparoscopic Surgery
Status: COMPLETED
Conditions: Intubation
Interventions: DEVICE: ProSeal LMA|DEVICE: ProSeal LMA, Tracheal Tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Preventing Tobacco Relapse With Omega-3s Trial
Status: WITHDRAWN
Conditions: Tobacco Dependence
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Feasibility, Safety and Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Hospitalized Patients With AECOPD
Status: RECRUITING
Conditions: COPD Exacerbation
Interventions: DRUG: Revefenacin (YUPELRI) & Formoterol (Perforomist)|DRUG: Albuterol Inhalation Aerosol (short-acting beta-agonists) & Ipratropium Aerosol (short-acting anticholinergic)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atomoxetine and Executive Function in PTSD
Status: NOT_YET_RECRUITING
Conditions: Posttraumatic Stress Disorder With Attention Defic
Interventions: DRUG: Atomoxetine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient's Preferences About Subcutaneous or Vaginal Progesterone Administration for Luteal Phase Support
Status: COMPLETED
Conditions: Progesterone|Luteal Phase Support|In Vitro Fertilization
Interventions: DRUG: Subcutaneous Progesterone|DRUG: Vaginal progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CO(Mbined Therapy of Malignant) S(Alivary Gland tu)M(Ours With)I(MRT and) c(Arbon Ions): COSMIC
Status: UNKNOWN
Conditions: Malignancy|Salivary Glands|Tumor
Interventions: RADIATION: carbon ion boost
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients
Status: WITHDRAWN
Conditions: Traumatic Brain Injury
Interventions: BEHAVIORAL: Rehabilitation therapy|PROCEDURE: Stellate ganglion block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Can Nebivolol Reverse Inappropriate Left Ventricular Mass in Hypertensive Patients?
Status: TERMINATED
Conditions: Hypertension
Interventions: DRUG: Nebivolol|DRUG: Metoprolol succinate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: BERRY- a Study of Sambucol ® in the Treatment, and Reduction of Symptoms in Participants With Coronavirus 19
Status: COMPLETED
Conditions: COVID-19
Interventions: DIETARY_SUPPLEMENT: Sambucol® Black Elderberry Original (Sambucus nigra) Liquid|DIETARY_SUPPLEMENT: Placebo for Sambucol® Black Elderberry Original (Sambucus nigra)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Transversus Abdominis Plane Catheter Following Kidney Transplantation
Status: UNKNOWN
Conditions: Pain, Postoperative|Kidney Transplant
Interventions: DRUG: Ropivacaine|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive Keratoconus
Status: NOT_YET_RECRUITING
Conditions: Progressive Keratoconus
Interventions: DEVICE: Therapeutic lens alone|COMBINATION_PRODUCT: Therapeutic lens + amniotic membrane (Visio-AMTRIX)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ORIN1001 in Patients With Advanced Solid Tumors and Relapsed Refractory Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Solid Tumor|Metastatic Breast Cancer
Interventions: DRUG: Abraxane
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Oral AB1010 in Adult Patients With Severe Persistent Corticosteroid Dependent Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: AB1010|DRUG: AB1010|DRUG: AB1010|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Acceptance and Commitment Therapy for Chronic Pain in SCI: Development and Testing of an eHealth Program
Status: ACTIVE_NOT_RECRUITING
Conditions: Spinal Cord Injuries
Interventions: BEHAVIORAL: Unguided use of the My SCI Toolkit program|BEHAVIORAL: Coached My SCI Toolkit
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid
Status: COMPLETED
Conditions: Brain Cancer|Brain Tumors|Cancer of Brain|Primary Brain Tumors|Brain Tumor, Primary
Interventions: DRUG: 5-aminolevulinic acid (5-ALA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: This Study is to Compare and Evaluate the Safety and Pharmacokinetic Characteristics (PK) After Administration of DW6014 and Each Component(Empagliflozin and Metformin) in Healthy Adult Volunteers in Fast Condition.
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: DW6014
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents
Status: COMPLETED
Conditions: Zika Virus|Zika Virus Infection|Virus Diseases|Flavivirus Infections|Flaviviral Diseases|Flaviviridae Infections|RNA Virus Infections
Interventions: BIOLOGICAL: VRC-ZKADNA090-00-VP|OTHER: VRC-PBSPLA043-00-VP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 1
Status: COMPLETED
Conditions: Early Caries Lesions
Interventions: DEVICE: CPP-ACP (GC Tooth Mousse)|DEVICE: CPP-ACP (GC MI Paste Plus)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: KW-6356|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Advanced Gastrointestinal Endoscopic Imaging
Status: TERMINATED
Conditions: Gastrointestinal Diseases|Gastric (Stomach) Cancer|Gastrointestinal Stromal Tumor (GIST)
Interventions: DEVICE: Dual axis endoscopic microscope|DEVICE: wide field fluorescence system|DEVICE: CellVizio|DRUG: fluorescent Peptide|DRUG: fluorescein|DRUG: indocyanine green
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation
Status: UNKNOWN
Conditions: Aging
Interventions: OTHER: Resistance training, LL|OTHER: Resistance training, HL|OTHER: Resistance training, HVHL|OTHER: Control group, CG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Endpoint Bioequivalence Study of Fluticasone Propionate & Salmeterol Xinafoate (100μg/50μg)
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: Fluticasone propionate/salmeterol|DRUG: Advair Diskus, 100 Mcg-50 Mcg Inhalation Powder|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of HS-10365 in Patients With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Nonsmall Cell Lung Cancer
Interventions: DRUG: HS-10365 capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prehabilitation and Posttransplant Training Program in Liver Transplantation
Status: ENROLLING_BY_INVITATION
Conditions: Liver Transplant; Complications|Cirrhosis, Liver|Hepatic Carcinoma
Interventions: OTHER: Prehabilitation|OTHER: Prehabilitation and posttransplant training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Thoracoscopic Exploration in Comparison to Exploratory Thoracotomy in Chest Trauma
Status: NOT_YET_RECRUITING
Conditions: Thoracic Injury
Interventions: PROCEDURE: Video Assisted Thoracoscopic Surgery (VATS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Enasidenib in People With Clonal Cytopenia of Undetermined Significance
Status: ACTIVE_NOT_RECRUITING
Conditions: Clonal Cytopenia of Undetermined Significance|CCUS Clonal Cytopenia of Undetermined Significance
Interventions: DRUG: Enasidenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Health Determinants on Physical Exercise Therapy With a Neurocognitive Focus on Chronic Low Back Pain
Status: UNKNOWN
Conditions: Chronic Low-back Pain
Interventions: BEHAVIORAL: Group of educational intervention on the neurophysiology of pain and physical exercises|BEHAVIORAL: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Arginine Therapy for Sickle Cell Disease Pain
Status: COMPLETED
Conditions: Sickle Cell Disease|Vaso-occlusive Pain Episode
Interventions: DRUG: L-arginine|DRUG: L-arginine Loading Dose|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy and Safety of KW-0761 in Chinese Subjects With Mycosis Fungoides or Sézary Syndrome Previously Treated With Systemic Therapy
Status: RECRUITING
Conditions: Cutaneous T-Cell Lymphoma
Interventions: DRUG: Mogamulizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytokine Gene Polymorphisms in Gastric Diseases
Status: UNKNOWN
Conditions: Gastric Ulcer|Duodenal Ulcer|Gastric Cancer
Interventions: PROCEDURE: IL-1, TNF-alpha, Il-10
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effectiveness and Safety of Minoxidil Foam Versus Placebo Foam for Androgenetic Alopecia
Status: COMPLETED
Conditions: Androgenetic Alopecia
Interventions: DRUG: Minoxidil|DRUG: vehicle of 5% Minoxidil topical foam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: RejuvenAir® System Trial for COPD With Chronic Bronchitis
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Bronchitis
Interventions: DEVICE: RejuvenAir System|DEVICE: Sham Control Procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Asthma Self-Management Education in Patients With Depressive Symptoms
Status: COMPLETED
Conditions: Asthma|Depression|Anxiety
Interventions: BEHAVIORAL: Asthma self-management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Skeletal Muscle Paralysis in Hypothermic Patients After Cardiac Arrest
Status: COMPLETED
Conditions: Cardiac Arrest With Successful Resuscitation|Hypothermia|Skeletal Muscle Relaxant Overdose
Interventions: DRUG: rocuronium|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Large Cell Lymphoma Pilot Study III
Status: COMPLETED
Conditions: Lymphoma, Large Cell|Lymphoma, Non-Hodgkin
Interventions: DRUG: Doxorubicin, Cotrimoxazole, Carboplatin, Ifosfamide, Dexamethasone, Prednisone, Vincristine, Cytarabine, Methotrexate, Etoposide, Cyclophosphamide, Vinblastine|PROCEDURE: Stem cell transplant,|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Natural History Study of Patients With Myotubular Myopathy and Other CentroNuclear Myopathies
Status: COMPLETED
Conditions: Centronuclear Myopathy
Interventions: OTHER: Standardized strength, respiratory and motor function assessments
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Sarcopenia, Active Aging and Oral Microbiota. Effects of HIIT in Older Adults
Status: COMPLETED
Conditions: Sarcopenia
Interventions: OTHER: HIIT|OTHER: MICT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Validation of a Subjective Rating Scale for Assessment of the Surgical Workspace in Laparoscopy
Status: COMPLETED
Conditions: Hernia, Inguinal
Interventions: PROCEDURE: Level of pneumoperitoneum 12-9-6 mmHg|PROCEDURE: Level of pneumoperitoneum 11-8-5 mmHg|PROCEDURE: Level of pneumoperitoneum 10-7-4 mmHg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Multi-Center, Prospective, Randomized, Comparison of AWBAT™-D vs. Xeroform™ or Glucan II™ for Treatment of Donor Sites in Burn Surgery
Status: UNKNOWN
Conditions: Treatment of Donor Site Burns
Interventions: DEVICE: AWBAT™-D and XEROFORM™ OR GLUCAN II™ dressings
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Letrozole|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study in Healthy People to Compare How 2 Different Low Dose Formulations of BI 1015550 Are Taken up in the Body
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DRUG: BI 1015550
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT