pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study of Obinutuzumab in Chinese Participants With CD20+ Malignant Disease
Status: COMPLETED
Conditions: Lymphocytic Leukemia, Chronic, Diffuse Large B-cell Lymphoma, Follicular Lymphoma
Interventions: DRUG: Obinutuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, One-arm and Open Clinical Study of Zanubrutinib in the Treatment of Immune Thrombocytopenia
Status: UNKNOWN
Conditions: Immune Thrombocytopenia|Treatment
Interventions: DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma|Brain Tumor|GBM
Interventions: DRUG: Pembrolizumab|DRUG: Vorinostat|DRUG: Temozolomide|RADIATION: Radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Raw Versus Other Milk Sources on Lactose Digestion
Status: COMPLETED
Conditions: Lactose Intolerance
Interventions: BEHAVIORAL: Raw Milk|BEHAVIORAL: Pasteurized Milk|BEHAVIORAL: Non-dairy milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Prospective Randomized Trial Comparing TRIPLE Site ventriculAr Stimulation Versus Conventional Pacing in CRT canDidates
Status: UNKNOWN
Conditions: Cardiac Resynchronization Therapy
Interventions: PROCEDURE: Cardiac resynchronization therapy implantation|DEVICE: Stimulation of 3 ventricular sites|DEVICE: Stimulation of 2 ventricular sites|DEVICE: Echocardiography
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients
Status: COMPLETED
Conditions: Photosensitive Epilepsy
Interventions: DRUG: ACT-709478 for oral use|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: TiZANidine 2 MG Oral Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcitriol in Combination With Ketoconazole and Therapeutic Hydrocortisone in Treating Patients With Prostate Cancer
Status: TERMINATED
Conditions: Prostate Adenocarcinoma|Recurrent Prostate Carcinoma|Stage III Prostate Cancer|Stage IV Prostate Cancer
Interventions: DIETARY_SUPPLEMENT: Calcitriol|DRUG: Ketoconazole|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study|DRUG: Therapeutic Hydrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification
Status: COMPLETED
Conditions: Cataracts
Interventions: DRUG: Moxifloxacin|DRUG: besifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Phase I Clinical Study Study of the Safety, Tolerability, and Pharmacokinetics of HX-1171 in Healthy Male Subjects
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: HX-1171
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Inhaled Furosemide for Transient Tachypnea of Newborn
Status: COMPLETED
Conditions: Respiratory Morbidity
Interventions: OTHER: Furosemide|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of SyB L-0501 in Combination With Rituximab in Patients With Untreated, Low-grade B Cell Non-Hodgkin's Lymphoma and Mantle Cell Lymphoma
Status: COMPLETED
Conditions: Low-grade B Cell Non-Hodgkin's Lymphoma|Mantle Cell Lymphoma Where Hematopoietic Stem Cell Transplantation is Not Indicated
Interventions: DRUG: SyB L-0501|DRUG: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of ARMA in Selective Subset of Refractory GERD Patients.
Status: RECRUITING
Conditions: GERD|Reflux|Reflux Esophagitis
Interventions: PROCEDURE: ARMA|PROCEDURE: UGI Endoscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Desflurane Versus Sevoflurane With Recent Bio-markers on Renal and Hepatic Functions
Status: COMPLETED
Conditions: Postoperative Complications
Interventions: DIAGNOSTIC_TEST: Neutrophil Gelatinase-Associated Lipocalin (NGAL)|DRUG: Desflurane|DRUG: Sevoflurane
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Exploratory Platform Trial to Evaluate Immunotherapy Combinations With Chemotherapy for the Treatment of Patients With Previously Untreated Metastatic Pancreatic Adenocarcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Pancreatic Adenocarcinoma
Interventions: DRUG: Nivolumab (Cohort A)|DRUG: Ipilimumab (Cohort A, B and C)|DRUG: Hydroxychloroquine (HCQ) (Cohort B)|DRUG: Nab-paclitaxel (nP) (Cohort A, B and C)|DRUG: Gemcitabine (gem) (Cohort A, B and C)|DRUG: NG350A (Cohort C)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Melanoma
Interventions: DRUG: Encorafenib|DRUG: Binimetinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: FP|DRUG: LABA|DRUG: LTRA|DRUG: LAMA|DRUG: Theophylline|DRUG: Oral Corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Pharmacokinetic and Metabolism Study of 14C-labeled RO5185426 on Patients With Metastatic Melanoma
Status: COMPLETED
Conditions: Malignant Melanoma
Interventions: DRUG: RO5185426
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Safety and Efficacy of Human CD19 Targeted DASH CAR-T Cells Injection for Subjects With R/R B-ALL
Status: RECRUITING
Conditions: B-cell Acute Lymphoblastic Leukemia
Interventions: DRUG: Human CD19 Targeted DASH CAR-T Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: adalimumab|BIOLOGICAL: adalimumab|BIOLOGICAL: adalimumab|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ZW25 (Zanidatamab) in Subjects With Advanced or Metastatic HER2-Amplified Biliary Tract Cancers
Status: COMPLETED
Conditions: HER2-amplified Biliary Tract Cancers
Interventions: DRUG: ZW25 (Zanidatamab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery
Status: SUSPENDED
Conditions: Valve Heart Disease|Elective Cesarean Delivery
Interventions: DRUG: Placebo|DRUG: Ketorolac-Lidocaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.
Status: COMPLETED
Conditions: Retina|Regional Blood Flow|Endotoxin, Escherichia Coli
Interventions: DRUG: vitamin and mineral supplement|DRUG: Escherichia coli Endotoxin (LPS)|DRUG: 100% O2|DRUG: nitroglycerin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Care for Older People With Diabetes Mellitus
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: SCOPE-DM|BEHAVIORAL: SCOPE-DM with 3 months' supply of glucometer|BEHAVIORAL: SCOPE-DM with 6 months' supply of glucometer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Differences in ECG- vs. proLonged cardIac MonItor-DeTected Atrial Fibrillation in STROKE Patients (DELIMIT AF-STROKE)
Status: ACTIVE_NOT_RECRUITING
Conditions: Stroke|Atrial Fibrillation|TIA
Interventions: DIAGNOSTIC_TEST: Prolonged cardiac monitoring|DIAGNOSTIC_TEST: ECG
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Intravenous Formulation of Guselkumab Using Prefilled Syringes and Final Vialed Product in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Guselkumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Prognostic Value of Cerebrospinal Fluid Immunoglobulin Free Light Chains in Patients With Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: DIAGNOSTIC_TEST: CSF immunoglobulin (Ig) free light chains (FLC) dosage
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluating the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of the Monoclonal Antibody PGT121.414.LS Administered Alone and in Combination With VRC07-523LS Via Intravenous or Subcutaneous Infusions in Healthy, HIV-uninfected Adult Participants
Status: COMPLETED
Conditions: HIV Infections
Interventions: BIOLOGICAL: PGT121.414.LS|BIOLOGICAL: VRC07-523LS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Treatment for CI-DME in Eyes With Very Good VA Study
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: PROCEDURE: Prompt Laser|DRUG: Prompt aflibercept|PROCEDURE: Deferred laser|DRUG: Deferred aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating Long-term Treatment With Spesolimab in People With a Skin Disease Called Hidradenitis Suppurativa Who Completed a Previous Clinical Trial
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: Spesolimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)
Status: COMPLETED
Conditions: Depression
Interventions: DRUG: Brexpiprazole|DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Drug-Drug Interaction - 3 Arm - Carboplatin/Paclitaxel, Dacarbazine
Status: COMPLETED
Conditions: Advanced Melanoma
Interventions: DRUG: Ipilimumab|DRUG: Carboplatin|DRUG: Paclitaxel|DRUG: Dacarbazine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Intelligent Nutrition Support Therapy for Hematopoietic Stem Cell Transplantation Recipients
Status: NOT_YET_RECRUITING
Conditions: Nutrition Aspect of Cancer|Stem Cell Transplant Complications
Interventions: OTHER: Parenteral nutrition;Enteral nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pazopanib Hydrochloride in Treating Patients With Stage IV Kidney Cancer
Status: COMPLETED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: DRUG: pazopanib hydrochloride|OTHER: laboratory biomarker analysis|OTHER: immunologic technique
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Necessity of Transnasal Gastroscopy in Routine Diagnostics - a Patient Centered Requirement Analysis
Status: COMPLETED
Conditions: Patient Safety
Interventions: PROCEDURE: Nasal Gastroscopy|PROCEDURE: Oral Gastroscopy, unsedated|PROCEDURE: Oral Gastroscopy, sedated|PROCEDURE: Oral Gastroscopy with transnasal endoscope, sedated
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy of rTMS (Repetitive Transcranial Magnetic Stimulation) on Patients With Somatoform Pain Disorder
Status: WITHDRAWN
Conditions: Pain
Interventions: DEVICE: repetitive Transcranial Magnetic Stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KOKON Consultation on Complementary Medicine in Oncology - a Pilot Study
Status: COMPLETED
Conditions: Breast-cancer
Interventions: BEHAVIORAL: Consultation by a trained physician|BEHAVIORAL: Consultation by an untrained physician
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: FMT for Postop Crohn's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Crohn Disease
Interventions: BIOLOGICAL: Capsule fecal microbiota material (cap-FMT)|BIOLOGICAL: Colonoscopic fecal microbiota material (colo-FMT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Nanoliposomal Irinotecan (Nal-IRI)-Containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma
Status: COMPLETED
Conditions: Pancreatic Cancer
Interventions: DRUG: nal-IRI|DRUG: 5 fluorouracil|DRUG: Leucovorin|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computerized Cognitive Training in Epilepsy
Status: WITHDRAWN
Conditions: Epilepsy
Interventions: BEHAVIORAL: Spatial Match Exercise|BEHAVIORAL: Temporal Sequence Reconstruction Exercise|BEHAVIORAL: Token Task Exercise|BEHAVIORAL: Story Recall Exercise|BEHAVIORAL: Sample-Match (Within Modality) Exercise|BEHAVIORAL: Pair-Match (Across-Modality) Exercise|BEHAVIORAL: Triad-FiguresExercise|BEHAVIORAL: Monster Garden Exercise|BEHAVIORAL: Memory Match Exercise|BEHAVIORAL: Memory Matrix Exercise|BEHAVIORAL: Familiar Faces Exercises|BEHAVIORAL: Lost in Migration Exercise|BEHAVIORAL: Playing Koi Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Reducing Disparities in Late Life Depression and Metabolic Syndrome
Status: COMPLETED
Conditions: Depressive Symptoms|Metabolic Syndrome X|Overweight|Obesity|Hypertension|Hyperglycemia|Dyslipidemias
Interventions: BEHAVIORAL: Generations older adult membership program|BEHAVIORAL: BRIGHTEN Heart Virtual Team intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation and Adoption of Care for Child Development in Day Care Centers
Status: COMPLETED
Conditions: Child Development
Interventions: BEHAVIORAL: Care for Child Development (CCD) program|BEHAVIORAL: Infant and Young Child feeding training by World Vision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CD19-targeted CAR T Cells （JWCAR029） for Primary Refractory Diffuse Large B Cell Lymphoma
Status: COMPLETED
Conditions: Diffuse Large B Cell Lymphoma
Interventions: BIOLOGICAL: JWCAR029 (CD19-targeted Chimeric Antigen Receptor Cells)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine
Status: COMPLETED
Conditions: Depression|Major Depressive Disorder
Interventions: DRUG: Buprenorphine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Assess AFM11 in Patients With Relapsed and/or Refractory CD19 Positive B-cell NHL
Status: TERMINATED
Conditions: Relapsed B-Cell Non-Hodgkin Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma
Interventions: DRUG: AFM11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Swimming Economy in Swimmers and Paraswimmers as a Function of SR(Stroke Rate) and V(Velocity) Manipulations (NePTUNE-3)
Status: UNKNOWN
Conditions: Swimming|Coordination Lack|Oxygen Consumption|Lactic Acid Blood Increased
Interventions: OTHER: Swimming economy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Yoga on Anesthesia Management
Status: COMPLETED
Conditions: Anesthesia|Closed Loop Anesthesia Delivery System (CLADS)
Interventions: BEHAVIORAL: pranayama yoga|OTHER: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Phase 3 Study of the Safety and Efficacy of Coagulation Factor VIIa (Recombinant) for the Prevention of Excessive Bleeding in Patients With Congenital Hemophilia A or B With Inhibitors to Factor VIII or IX Undergoing Elective Major Surgical Procedures SCOPE HIM
Status: RECRUITING
Conditions: Hemophilia
Interventions: BIOLOGICAL: Coagulation Factor VIIa (Recombinant)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IVIg to Treat BK Viremia in Kidney Transplant Recipients
Status: COMPLETED
Conditions: Kidney Transplantation|BK Virus|Isoantibodies
Interventions: BIOLOGICAL: IVIg|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DEfibrillators
Status: COMPLETED
Conditions: Heart Failure, Systolic|Heart Failure
Interventions: OTHER: Educational video and/or handout
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Length of the Femoral Stem in Arthroplasty Done for Patients With Proximal Femoral Metastatic Lesion
Status: COMPLETED
Conditions: Metastatic Bone Tumor|Pathological Fracture|Arthroplasty
Interventions: DEVICE: femoral stem in hip arthroplasty
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Comparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar
Status: UNKNOWN
Conditions: Placenta Accreta
Interventions: PROCEDURE: Cesarean section|DEVICE: Transabdominal ultrasound|DEVICE: Transvaginal ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: BIOLUMA: Biomarkers for Nivolumab and Ipilimumab and Evaluation of the Combination in Lung Cancer
Status: COMPLETED
Conditions: Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell Lung
Interventions: DRUG: Nivolumab, Ipilimumab|DRUG: Nivolumab, Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety & Efficacy of TC-5619 in Adults With Inattentive-predominant Attention Deficit/Hyperactivity Disorder (ADHD)
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: TC-5619-238 5mg|DRUG: TC-5619-238 25mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS)
Status: COMPLETED
Conditions: Coronary Arteriosclerosis|Cardiomyopathies|Heart Defects, Congenital|Heart Valve Diseases
Interventions: PROCEDURE: Multidetector Computed Tomography Coronary Angiography
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Brief Cognitive Behavioural Therapy for Insomnia Versus Sleep Hygiene for Sleep Difficulties in Early Pregnancy
Status: NOT_YET_RECRUITING
Conditions: Sleep Disturbance|Perinatal Anxiety|Perinatal Depression
Interventions: BEHAVIORAL: Sleep Hygiene Workshop|BEHAVIORAL: Cognitive Behavioural Therapy for Insomnia Workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Infants in Brazil
Status: COMPLETED
Conditions: Vaccines, Pneumococcal Conjugate Vaccine
Interventions: BIOLOGICAL: 13-Valent Pneumococcal Conjugate Vaccine (13vPnC)|BIOLOGICAL: 7-Valent Pneumococcal Conjugate Vaccine (7vPnc)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Community Paramedicine Initiative for Older Adults Living in Subsidized Housing (CHAP-EMS/CP@Clinic)
Status: COMPLETED
Conditions: Cardiovascular Diseases|Diabetes Mellitus
Interventions: BEHAVIORAL: CHAP-EMS/CP@clinic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Computer Guided Lag Screw Fixation Versus Conventional Lag Screw Fixation in Anterior Mandibular Fractures
Status: UNKNOWN
Conditions: Mandible Fracture
Interventions: PROCEDURE: Computer guided lag screw fixation|PROCEDURE: Conventional lag screw fixation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Home-based Intervention to Improve the Diet Quality of Preschoolers
Status: COMPLETED
Conditions: Diet Modification
Interventions: BEHAVIORAL: Healthy Feeding, Healthy Eating|BEHAVIORAL: Reading Readiness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of GnRH Antagonist vs Agonist Long on IVF Outcome, Peak Estradiol Level,and Duration of Stimulation
Status: COMPLETED
Conditions: Fertility
Interventions: DRUG: Bravelle and Menopur|DRUG: Agonist|DRUG: Antagonist
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avelumab, Binimetinib and Talazoparib in Patients With Locally Advanced or Metastatic RAS-mutant Solid Tumors
Status: TERMINATED
Conditions: Pancreatic Cancer
Interventions: DRUG: Avelumab|DRUG: Binimetinib|DRUG: Talazoparib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis
Status: RECRUITING
Conditions: Stroke|Stroke, Ischemic|Atherosclerosis|Myocardial Infarction|Coronary Syndrome|TIA|Cardiac Disease|Cerebral Infarction
Interventions: DRUG: Colchicine 0.5 MG|DRUG: Ticagrelor 90mg|DRUG: Aspirin 75-300mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Growth of Infants Fed an Extensively Hydrolyzed Infant Formula
Status: COMPLETED
Conditions: Growth
Interventions: OTHER: Extensively hydrolyzed whey infant formula|OTHER: Extensively hydrolyzed casein infant formula
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Multi-center Trial to Improve Nocturia and Sleep in Older Adults
Status: RECRUITING
Conditions: Nocturia|Insomnia
Interventions: BEHAVIORAL: Integrated Behavioral Therapy Program|BEHAVIORAL: Health Education Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lateralization After IntraMedullary Nailing of InterTrochanteric Hip Fractures, Clinical and Radiographic Outcomes
Status: COMPLETED
Conditions: Intertrochanteric Fractures
Interventions: DEVICE: Telescoping Lag Screw|DEVICE: Standard lag Screw|DEVICE: Standard lag screw with addition of worm screw
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study for Evaluation of the Safety, Pharmacokinetics, and Antiviral Activity of UB-421 Subcutaneous Formulation in HIV Infected Adults
Status: NOT_YET_RECRUITING
Conditions: HIV-1-infection
Interventions: BIOLOGICAL: UB-421 SC
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Response and Effectiveness of RSD1235 in Subjects With Atrial Fibrillation or Atrial Flutter
Status: COMPLETED
Conditions: Atrial Flutter|Atrial Fibrillation
Interventions: DRUG: RSD1235|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean
Status: COMPLETED
Conditions: Obstetrical Complications|Hemorrhage|Labor and Delivery
Interventions: DRUG: Tranexamic Acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Different Radiation Dose With Concurrent Chemotherapy for Thoracic Esophageal Carcinoma
Status: COMPLETED
Conditions: Esophageal Cancer
Interventions: RADIATION: High-dose|RADIATION: Standard-dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
Status: UNKNOWN
Conditions: Colorectal Neoplasms|Diverticulitis|Inflammatory Bowel Diseases|Surgical Site Infection
Interventions: DRUG: Polyethylene Glycol|DRUG: Neomycin|DRUG: Metronidazole Hydrochloride|PROCEDURE: Therapeutic Conventional Surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Delivering Food Resources & Kitchen Skills (FoRKS) to Adults With Food Insecurity and Hypertension
Status: RECRUITING
Conditions: Food Insecurity|Hypertension|Nutrition|Disease Management
Interventions: BEHAVIORAL: Food Resources & Kitchen Skills (FoRKS)|BEHAVIORAL: Enhanced Usual Care (EUC)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Oral MDV3100 in Chemotherapy-Naive Patients With Progressive Metastatic Prostate Cancer
Status: COMPLETED
Conditions: Prostate Cancer
Interventions: DRUG: Enzalutamide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Outcome of Vinpocetine in Diabetic Nephropathy
Status: RECRUITING
Conditions: Diabetic Kidney Disease|Diabetic Nephropathies
Interventions: DRUG: Vinpocetine|DRUG: Standard Therapy|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Umbilical Cord-Derived Mesenchymal Stem Cells for Rheumatoid Arthritis
Status: UNKNOWN
Conditions: Rheumatoid Arthritis
Interventions: BIOLOGICAL: Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs)|DRUG: Rheumatoid Arthritis With Disease-Modifying Drugs (DMARDs)|BIOLOGICAL: UC-MSC+DMARDS
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploring the Effects of Spinal Cord Stimulation in Parkinson's Disease.
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Spinal Cord Stimulator (SCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Transcutaneous Electrical Nerve Stimulation in Patients With Angina and Non-Obstructive Coronary Arteries
Status: RECRUITING
Conditions: Microvascular Angina|Vasospastic Angina
Interventions: DEVICE: Transcutaneous Electrical Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Personalized Tumorogram-based Therapy in Cancer Established From Patient-derived Organoid
Status: NOT_YET_RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Mallya in Type 2 Diabetes Transiting From Oral Antidiabetic Drugs to iGlarLixi
Status: RECRUITING
Conditions: Mallya
Interventions: OTHER: Mallya cap|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures
Status: COMPLETED
Conditions: Partial Epilepsy
Interventions: DRUG: YKP3089
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Celecoxib After Tonsillectomy
Status: COMPLETED
Conditions: Tonsillectomy
Interventions: DRUG: Celecoxib|OTHER: Placebo|DRUG: Acetaminophen|DRUG: Oxycodone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Inflammation and Treatment of Bacterial Vaginosis Near Term
Status: COMPLETED
Conditions: Bacterial Vaginosis
Interventions: DRUG: Metronidazole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Macular Edema Nepafenac vs. Difluprednate Uveitis Trial
Status: TERMINATED
Conditions: Uveitis|Macular Edema
Interventions: DRUG: Difluprednate|DRUG: Nepafenac|DRUG: Prednisolone acetate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa
Status: COMPLETED
Conditions: Anorexia Nervosa
Interventions: DRUG: Hormone replacement therapy (estrogen/progestin)|OTHER: Placebo (Sugar Pill)|DRUG: Dehydroepiandrosterone (DHEA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A First-In-Human Study of the Study Medicine, Called PF-07291177, in Healthy Adult Participants
Status: WITHDRAWN
Conditions: Healthy Participants
Interventions: DRUG: PF-07291177|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: IMProving Outcomes With ACT After Knee Surgery
Status: NOT_YET_RECRUITING
Conditions: Total Knee Arthroplasty|Knee Osteoarthritis
Interventions: BEHAVIORAL: Acceptance and Commitment Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab +/- Bevacizumab for Recurrent GBM
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: Pembrolizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Remote Cardiac Rehab for Adolescents With Congenital Heart Disease
Status: RECRUITING
Conditions: Congenital Heart Disease in Children
Interventions: BEHAVIORAL: Remote Cardiac Rehabilitation|BEHAVIORAL: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen (CDO) Therapy to Standard Moist Wound Therapy (MWT) in the Treatment of Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DEVICE: CDO electrochemical tissue oxygenation system|DEVICE: Moist Wound Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alcohol Cessation Intervention in an Acute Surgical Setting
Status: COMPLETED
Conditions: Acute Fracture Surgery|Alcohol Cessation Intervention|Postoperative Complications|Infection|Ankle Injuries
Interventions: OTHER: GSP-A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study Investigating Formulations of Vortioxetine Applied Under the Tongue in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Vortioxetine IV|DRUG: Vortioxetine SLA|DRUG: Vortioxetine SLB|DRUG: Vortioxetine SLC
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Single Centre Open Label Comparison of [I-123]-Ortho-Iodohippuric Acid (OIH) With [Tc-99m]-Mercaptoacetyltriglycine (MAG3) for Assessment of Renal Tubular Function
Status: COMPLETED
Conditions: Renal Function Impairment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Terlipressin Infusion Alone Vs Terlipressin With Noradrenaline Infusion In The Treatment of Hepatorenal Syndrome Type 1
Status: COMPLETED
Conditions: Type 1 HEPATO RENAL SYNDROME(HRS)
Interventions: DRUG: Terlipressin|DRUG: Terlipressin and Noradrenaline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Usefulness of Genotyping to Predict Docetaxel Exposure and Adverse Events
Status: COMPLETED
Conditions: CYP3A Phenotyping|CYP3A5 and MDR1 Genotyping|Docetaxel Toxicity|Associations Between Genetic Data and Docetaxel Toxicity
Interventions: DRUG: docetaxel + CEF
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Spironolactone in CKD Enabled by Chlorthalidone: PILOT
Status: RECRUITING
Conditions: Renal Insufficiency|Chronic Hypertension
Interventions: DRUG: Spironolactone|DRUG: Chlorthalidone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Tolerance and Efficacy Nicotinamide (Vitamin B3) in Dominant Optic Atrophy OPA1
Status: NOT_YET_RECRUITING
Conditions: Nicotinamide Adverse Reaction
Interventions: DRUG: Nicotinamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: N-Acetylcysteine|DRUG: N-Acetylcysteine|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors
Status: RECRUITING
Conditions: Liver Cancer|Rhabdomyosarcoma|Malignant Rhabdoid Tumor|Liposarcoma|Wilms Tumor|Yolk Sac Tumor
Interventions: GENETIC: CARE T cells|DRUG: Cytoxan|DRUG: Fludara
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Dose Response Relationship of Ulinastatin for Acute Respiratory Distress Syndrome(ARDS)
Status: UNKNOWN
Conditions: Acute Respiratory Distress Syndrome
Interventions: DRUG: ulinastatin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase 1 Dose-Escalation Study of Subcutaneously(SC) Administered RUC-4
Status: COMPLETED
Conditions: Coronary Disease
Interventions: DRUG: RUC-4 Compound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA)
Status: UNKNOWN
Conditions: Primary Osteoarthritis Requiring Total Hip Replacement
Interventions: DRUG: LIA|DRUG: I/T morphine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Renal Effect of Pentoxyphylline in High Risk Patients Undergoing Angiography
Status: WITHDRAWN
Conditions: Contrast Induced Nephropathy|Diabetes Mellitus
Interventions: DRUG: pentoxyphylline|DRUG: placebo|DRUG: pentoxiphylline|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of Pyrotinib Plus Capecitabine Combined With SRT in HER2+ MBC With Brain Metastases
Status: RECRUITING
Conditions: HER2-positive Metastatic Breast Cancer
Interventions: COMBINATION_PRODUCT: radiation combined with pyrotinib and capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High-Dose Post-Transplant Cyclophosphamide and Bortezomib (CyBor) for the Prevention of Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Status: COMPLETED
Conditions: GVHD
Interventions: DRUG: Bortezomib|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL
Status: UNKNOWN
Conditions: Age-related Cataract
Interventions: DRUG: Hylo-Comod eye drop|DRUG: Tears Naturale Forte eye drop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Pemetrexed and Platinum Use in the Neoadjuvant Setting for Resectable Stage II and IIIA Lung Adenocarcinoma (ECTOP-1002)
Status: COMPLETED
Conditions: Lung Adenocarcinoma
Interventions: DRUG: Pemetrexed|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abraxane With or Without Tigatuzumab in Patients With Metastatic, Triple Negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Triple Negative Breast Cancer|Stage IV Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: Abraxane alone|DRUG: Abraxane + Tigatuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy, Onset of Effect, and Safety of Alfuzosin Once Daily in the Treatment of Lower Urinary Tract Symptoms of Benign Prostatic Hyperplasia: A Randomized, Placebo-Controlled Trial Using an Acute International Prostate Score
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: ALFUZOSIN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Combination of Beclomethasone Dipropionate and Formoterol Fumarate Versus Single Components Assessed by Knemometry and Urinary Cortisol Measurements in Asthmatic Children
Status: WITHDRAWN
Conditions: Asthma in Children
Interventions: DRUG: combination of beclomethasone dipropionate 50µg + formoterol fumarate 6µg|DRUG: free combination of beclomethasone dipropionate 100µg + Formoterol fumarate 6µg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Yoga on Care Load, Quality of Life, and Psychological Well-Being of Indivıduals With Special Needs
Status: COMPLETED
Conditions: Caregiver Burden|Quality of Life|Psychological Stress
Interventions: OTHER: Yoga Practice|OTHER: Ongoing caregivers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
Status: UNKNOWN
Conditions: Coronary Artery Occlusive Disease
Interventions: DRUG: Iloprost|DRUG: Control (Normal saline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Diclofenac Sodium Topical Gel to Reduce Injection Site Discomfort in Patients Taking Glatiramer Acetate
Status: COMPLETED
Conditions: Multiple Sclerosis
Interventions: DRUG: diclofenac sodium topical gel|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Sacubitril/ValsarTan on MyocardIal OxygenatioN and Fibrosis in Heart Failure With Preserved Ejection Fraction
Status: WITHDRAWN
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DRUG: Sacubitril-Valsartan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Veterans Response to Dosage in Chiropractic Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Low Back Pain|Patient Acceptance of Health Care|Veterans Health
Interventions: OTHER: Chiropractic Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia
Status: COMPLETED
Conditions: Restless Legs Syndrome|Insomnia|Sleep Disorder
Interventions: DRUG: Suvorexant|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic/Pharmacodynamic Characteristics and Safety/Tolerability of MT921 in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: MT921|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Gemcitabine With or Without Bavituximab in Patients With Previously Untreated Stage IV Pancreatic Cancer
Status: COMPLETED
Conditions: Metastatic Pancreatic Cancer
Interventions: BIOLOGICAL: bavituximab|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT