pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: An Investigation of the Efficacy of OHEM for Improving Oral Hygiene in Children
Status: NOT_YET_RECRUITING
Conditions: Dental Plaque|Gingivitis
Interventions: BEHAVIORAL: Oral Health Educational Module for Mothers (OHEM) lecture|BEHAVIORAL: Oral Health Educational Module for Mothers (OHEM) exhibition|BEHAVIORAL: Oral Health Educational Module for Mothers (OHEM) demonstration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Combining tDCS With VR-based Motor Training in Stroke
Status: UNKNOWN
Conditions: Virtual Reality Based Therapy|Anodal tDCS|Occupational Therapy|Sham tDCS
Interventions: BEHAVIORAL: Virtual Reality-based therapy for upper-limbs motor rehabilitation|DEVICE: Anodal transcranial direct-current stimulation (tDCS)|BEHAVIORAL: Occupational Therapy for upper-limbs motor rehabilitation|DEVICE: Sham transcranial direct-current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ophthalmic Compatibility During Seven Days of Continuous Wear of Silicone Hydrogel Lenses
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Narafilcon A contact lens|DEVICE: Lotrafilcon A contact lens|DEVICE: Galyfilcon A contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder (MDD)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Agomelatine (AGO178C)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
Status: RECRUITING
Conditions: Aneurysm|Dissection|Aortic Root Aneurysm|Aortic Root Dissection|Carotid Artery Injuries|Aortic Arch|Bypass Extremity Graft|Occlusive Vascular Disease|Aortic Diseases
Interventions: DEVICE: Gelsoft Plus Vascular Graft|DEVICE: Vascular Bypass Graft|DEVICE: Cardiovascular Patch|DEVICE: Gelweave Vascular Graft|DEVICE: Gelweave Valsalva Vascular Graft
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Reducing Pain and Promoting Neurodevelopment Among Preterm Neonates
Status: COMPLETED
Conditions: Neonatal Disease|Neonatal Disorder
Interventions: OTHER: Multisensory stimulation with soft tissue therapy|OTHER: Routine hospital care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vigabatrin for the Treatment of Cocaine Dependency
Status: COMPLETED
Conditions: Cocaine Addiction|Cocaine Dependence
Interventions: DRUG: Vigabatrin|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase II Study of Single Agent OSI-7904L in Patients With Gastric or Gastroesophageal (GEJ) Cancer
Status: COMPLETED
Conditions: Gastroesophageal Adenocarcinoma|Gastric Adenocarcinoma
Interventions: DRUG: OSI-7904L
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Sit Less Program for Patients With Type 2 Diabetes
Status: TERMINATED
Conditions: Type 2 Diabetes|Sedentary Behavior|Sedentary Time|Physical Activity
Interventions: BEHAVIORAL: Sit Less Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Bioavailability of ABT-333 Tablet Versus First in Human (FIH) Capsule Formulation and Safety, Tolerability and PK Study of Single Doses of ABT-333 in Healthy Volunteers
Status: COMPLETED
Conditions: HCV Infection
Interventions: DRUG: ABT-333 Tablet|DRUG: Placebo|DRUG: ABT-333 Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Resveratrol and the Metabolic Syndrome
Status: COMPLETED
Conditions: Obesity|Insulin Resistance|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Placebo|DIETARY_SUPPLEMENT: Resveratrol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Iron Isomaltoside 1000 (Monofer®) Administered by a High Dosing Regimen in Subjects With Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Inflammatory Bowel Disease
Interventions: DRUG: Iron Isomaltoside 1000
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Study of Eniluracil + 5-Fluorouracil (5-FU) + Leucovorin Versus Capecitabine in Metastatic Breast Cancer
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Eniluracil|DRUG: 5-Fluorouracil|DRUG: Leucovorin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cryoneurolysis for Acute Postoperative Pain Following Total Knee Arthroplasty
Status: RECRUITING
Conditions: Acute Postoperative Pain
Interventions: PROCEDURE: Cryoneurolysis|PROCEDURE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: S.M.A.R.T.® Nitinol Self-Expandable Stent in the Treatment of Obstructive Superficial Femoral Artery Disease
Status: COMPLETED
Conditions: Superficial Femoral Artery Disease
Interventions: DEVICE: S.M.A.R.T. ® Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Potential Interaction Between ASP8062 and Alcohol in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: ASP8062|DRUG: Alcohol|DRUG: ASP8062 Placebo|DRUG: Alcohol Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Neutrophilic Asthma Study With Navarixin (MK-7123, SCH 527123) (MK-7123-017)(COMPLETED)
Status: COMPLETED
Conditions: Neutrophilic Asthma
Interventions: DRUG: Navarixin|DRUG: Placebo|DRUG: Rescue medication
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic Profile and Safety of Fluticasone Propionate and Albuterol Sulfate in Combination When Compared to Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) in Children Aged 4 to 11 Years Old
Status: RECRUITING
Conditions: Asthma
Interventions: DRUG: TEV-56248|DRUG: Fp MDPI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Beta-blockade in Unruptured Intracranial Aneurysm
Status: NOT_YET_RECRUITING
Conditions: Intracranial Aneurysm
Interventions: DRUG: Nebivolol|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Additional Heidelberg Engineering SPECTRALIS With OCT Angiography Module (OCTA Module) Scan Types
Status: COMPLETED
Conditions: Retinal Vascular|Normal Eyes
Interventions: DEVICE: OCT Angiography|DEVICE: Color Fundus Photography|DEVICE: Optical Coherence Tomography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Congenital Muscle Disease Study of Patient and Family Reported Medical Information
Status: RECRUITING
Conditions: Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency|Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy)|Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Fatty Liver and Infantile-onset Cataract Caused by TRAPPC11 Mutations)|Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan)|Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan and Epilepsy)|Alpha-Dystroglycanopathy (Dystroglycanopathy, Congenital With or Without Mental Retardation (Formerly MDC1C))|Alpha-Dystroglycanopathy (Fukuyama CMD)|Alpha-Dystroglycanopathy (LGMDR09 FKRP Related (Formerly LGMD2I))|Alpha-Dystroglycanopathy (LGMDR11 POMT1 Related (Formerly LGMD2K))|Alpha-Dystroglycanopathy (LGMDR13 FKTN Related (Formerly LGMD2M))|Alpha-Dystroglycanopathy (LGMDR14 POMT2 Related (Formerly LGMD2N))|Alpha-Dystroglycanopathy (LGMDR15 POMGnT1 Related (Formerly LGMD2O))|Alpha-Dystroglycanopathy (LGMDR19 GMPPB Related (Formerly LGMD2T))|Alpha-Dystroglycanopathy (LGMDR20 ISPD Related (Formerly LGMD2U))|Alpha-Dystroglycanopathy (LGMDR24 POMGnT2 Related)|Alpha-Dystroglycanopathy (Muscle Eye Brain Disease (MEB))|Alpha-Dystroglycanopathy (Walker Warburg Syndrome (WWS))|Choline Kinase B Receptor - CHKB|Collagen VI Related Disorders|Collagen XII Related Disorders|Congenital Muscular Dystrophy Not Otherwise Specified (Including Merosin Positive)|Congenital Muscular Dystrophy With Cataracts and Intellectual Disability (MDCCAID)|Congenital Muscular Dystrophy With Joint Hyperlaxity|Congenital Muscular Dystrophy With Rigid Spine Related to ACTA1|Emery-Dreifuss Muscular Dystrophy|GOLGA2-related Congenital Muscle Dystrophy With Brain Involvement|LMNA Related Disorders|Merosin Deficient CMD (Full or Partial)|Nesprin Related MD (SYNE1)|SELENON Related Disorders (Previously Known as SEPN1)|SELENON Related Myopathy (Aka SEPN1)|Telethonin CMD|Congenital Myasthenic Syndrome|Limb-Girdle Muscular Dystrophy|LGMDD01 - DNAJB6 (Formerly LGMD1D)|LGMDD05 - Collagen VI Related Bethlem Myopathy (Dominant)|LGMDR07 - Telethonin (TCAP) Related (Formerly LGMD2G)|LGMDR08 - TRIM Related (Formerly LGMD2H)|LGMDR09 - FKRP Related (Formerly LGMD2I)|LGMDR10 - Titin (TTN) Related (Formerly LGMD2J)|LGMDR11 - POMT1 Related (Formerly LGMD2K)|LGMDR13 - Fukutin (FKTN) Related (Formerly LGMD2M)|LGMDR14 - POMT2 Related (Formerly LGMD2N)|LGMDR15 - POMGnT1 Related (Formerly LGMD2O)|LGMDR16 - DAG1 Related Dystroglycanopathy (Formerly LGMD2P)|LGMDR17 - Plectin (PLEC) Related (Formerly LGMD2Q)|LGMDR18 - TRAPPC11 Related (Formerly LGMD2S)|LGMDR19 - GMPPB Related (Formerly LGMD2T)|LGMDR20 - ISPD Related (Formerly LGMD2U)|LGMDR22 - Collagen VI Related Bethlem Myopathy (Recessive)|LGMDR23 - LAMA2 Related|LGMDR24 - POMGnT2 Related
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cetuximab Plus Irinotecan in Patients With NeoRAS Wild-type Metastatic Colorectal Cancer In Third-line Therapy
Status: RECRUITING
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Cetuximab and irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dietary Intake and Circulating Levels of Branched Chain Amino Acids
Status: COMPLETED
Conditions: Dietary Intake of Branched Chain Amino Acids
Interventions: OTHER: Diet high in amino acid levels|OTHER: Diet low in amino acid levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Role of miR-30 Family Dysregulation in Response to Antipsychotic Treatment
Status: UNKNOWN
Conditions: Schizophrenia
Interventions: DRUG: Risperidone|DRUG: Olanzapine|DRUG: Quetiapine|DRUG: Aripiprazole|DRUG: Ziprasidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects and Dose-response of Manual Therapy in the ROM of the Ankle in Older People
Status: COMPLETED
Conditions: Aging Problems
Interventions: OTHER: Experimental|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nicotine Patch Bioequivalence Study
Status: COMPLETED
Conditions: Healthy Smokers
Interventions: DRUG: V0116 transdermal patch (Test treatment )|DRUG: Nicotine transdermal patch (Reference Treatment )
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study of Experimental Models of Pain and Inflammation.
Status: COMPLETED
Conditions: Pain|Inflammation
Interventions: DRUG: Ibuprofen|DRUG: Placebo tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Chk2 Inhibitor for Recurrent EpitheliAl periToneal, fallopIan or oVarian cancEr (CREATIVE Phase IA Trial)
Status: RECRUITING
Conditions: Platinum-resistant Ovarian Cancer|Platinum-refractory Ovarian Carcinoma|Platinum-Resistant Fallopian Tube Carcinoma|Platinum-Resistant Primary Peritoneal Carcinoma
Interventions: DRUG: PHI-101 administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open Label Study of Sargramostim Among Patients Receiving Myelosuppressive Induction Chemotherapy for Acute Myelogenous Leukemia
Status: WITHDRAWN
Conditions: Acute Myeloid Leukemia NOS
Interventions: DRUG: sargramostim GZ402664
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pneumonia Vaccine in Liver Transplant Recipients: a Booster Strategy Using a Conjugate Vaccine
Status: UNKNOWN
Conditions: Transplant
Interventions: BIOLOGICAL: The polysaccharide vaccine Pneumovax (Merck-Frosst)|BIOLOGICAL: The conjugate vaccine used will be Prevnar (Wyeth vaccines)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Effect of Vernonia Cinerea Lozenges as a Smoking Cessation Aid in Patients With Non-communicable Diseases
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DIETARY_SUPPLEMENT: Vernonia cinerea|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Monthly Replacement Lenses in Habitual Soft Contact Lens Wearers Who Report Frequent Digital Devise Use
Status: COMPLETED
Conditions: Ametropia
Interventions: DEVICE: Lens A (comfilcon A lens)|DEVICE: Lens B (lehfilcon A lens)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Meditation or Education for Alzheimer Caregivers
Status: COMPLETED
Conditions: Caregivers|Alzheimer's Disease
Interventions: BEHAVIORAL: Meditation|BEHAVIORAL: Education|BEHAVIORAL: Respite only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis
Status: RECRUITING
Conditions: Brain Metastases|Brain Cancer
Interventions: DRUG: 18F-Fluciclovine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of Epratuzumab (hLL2) in Patients With Waldenstrom's Macroglobulinemia
Status: TERMINATED
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Epratuzumab (hLL2- anti-CD22 humanized antibody)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Handling Oxygenation Targets in the Intensive Care Unit
Status: COMPLETED
Conditions: Hypoxemic Respiratory Failure|Oxygen Toxicity
Interventions: DRUG: Oxygen|DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of Safety, Tolerability and Pharmacokinetics of Serelaxin in Japanese Acute Heart Failure (AHF) Patients
Status: COMPLETED
Conditions: Acute Heart Failure
Interventions: DRUG: Serelaxin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Social Network Approach for Improving Medication Assisted Treatment and HIV Prevention and Medical Care Among People Who Inject Drugs in Ukraine
Status: RECRUITING
Conditions: HIV
Interventions: BEHAVIORAL: Peer education & communications|BEHAVIORAL: Standard of care educational
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Control of Pain Due to Dentin Hypersensitivity in Individuals With Molar-incisor Hypomineralization
Status: UNKNOWN
Conditions: Dentin Sensitivity|Molar Incisor Hypomineralization
Interventions: OTHER: Hygiene Instructions|PROCEDURE: Sealant application|RADIATION: Low-level Laser
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Post Burn Pruritus Study in Patients Undergoing Wound Healing
Status: COMPLETED
Conditions: Itching
Interventions: DRUG: Ondansetron (Zofran)|DRUG: Diphenhydramine (Benadryl)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Vinorelbine in Treating Older Women Who Have Metastatic Breast Cancer With or Without Bone Involvement
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: capecitabine|DRUG: vinorelbine tartrate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: GEN-001 (Live Biotherapeutic Product) and Avelumab Combination Study for Patients With Solid Tumors Who Have Progressed on Anti-PD-(L)1 Therapy
Status: COMPLETED
Conditions: Solid Tumor|Non Small Cell Lung Cancer|Squamous Cell Carcinoma of Head and Neck|Urothelial Carcinoma
Interventions: DRUG: GEN-001|DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tools for Distance Delivery of an Evidence-based AD Family Caregiver Intervention
Status: COMPLETED
Conditions: Alzheimer's Disease|Dementia
Interventions: OTHER: Online counseling via Zoom teleconferencing|OTHER: Telephone support as needed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Differences in Urine NGAL Levels in Patients Undergoing RIRS With or Without Ureteral Access Sheath
Status: COMPLETED
Conditions: Urolithiasis
Interventions: DEVICE: RIRS with ureteral access sheath|DEVICE: RIRS without ureteral access sheath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Interventions: DRUG: TAK-788|DRUG: Pemetrexed|DRUG: Cisplatin|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mosunetuzumab With Lenalidomide Augmentation as First-line Therapy for Follicular and Marginal Zone Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma|Marginal Zone Lymphoma|B-cell Lymphoma
Interventions: DRUG: Mosunetuzumab|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcome After Surgical Resection of Gastrointestinal Stromal Tumors (GIST) in the Second Part of Duodenum
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor of Duodenum
Interventions: PROCEDURE: surgical resection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
Status: TERMINATED
Conditions: Carotid Stenosis
Interventions: DRUG: Fasudil Hydrochloride|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety Study of Jaktinib in Subjects With Active Ankylosing Spondylitis(AS)
Status: RECRUITING
Conditions: Ankylosing Spondylitis
Interventions: DRUG: Jaktinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemtuzumab Chemotherapy MRD Levels; Glasdegib Post-transplant, Adult Untreated, de Novo, Fav Interm Risk AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Glasdegib|DRUG: Gemtuzumab Ozogamicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COMPARISON OF SILODOSIN AND TAMSULOSIN IN MEDICAL EXPULSIVE THERAPY OF DISTAL URETERIC CALCULI
Status: COMPLETED
Conditions: Silodosin, Tamsulosin, Medical Expulsive Therapy, Distal Ureteric Calculi
Interventions: DRUG: Silodosin|DRUG: Tamsulosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ommaya Reservoir Placement at the Time of Biopsy for Longitudinal Biomarker Collection in Patients With Brain Tumors
Status: RECRUITING
Conditions: Brain Neoplasms
Interventions: PROCEDURE: Intracranial Catheter Placement|PROCEDURE: Lumbar Puncture|PROCEDURE: Biopsy|PROCEDURE: Biospecimen Collection|PROCEDURE: Computed Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Proprioception, Physical Performance, and Passing Accuracy in Adolescent Basketball Players
Status: COMPLETED
Conditions: Basketball Players
Interventions: DIAGNOSTIC_TEST: Force Sense|DIAGNOSTIC_TEST: Joint Reproduction Sense|DIAGNOSTIC_TEST: Seated Medicine Ball Throw|DIAGNOSTIC_TEST: Closed Kinetic Chain Upper Extremity Stability Test|DIAGNOSTIC_TEST: Passing Accuracy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase3)
Status: COMPLETED
Conditions: Muscle Spasticity
Interventions: DRUG: CORETOX®|DRUG: BOTOX®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin
Status: COMPLETED
Conditions: Cervical Dystonia|Blepharospasm|Limb Dystonia|Hemifacial Spasm|Spasticity, Muscle|Fragments of Torsion Dystonia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Maitland Mobilization in Shoulder Pathology
Status: COMPLETED
Conditions: Tendinosis
Interventions: PROCEDURE: Maitland|PROCEDURE: Tens, exercise, SW|PROCEDURE: Conventional physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain
Status: COMPLETED
Conditions: Chronic Pain|Smoking|Smoking Cessation
Interventions: BEHAVIORAL: Tailored intervention|BEHAVIORAL: Ask-Advise-Refer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis
Status: COMPLETED
Conditions: Chronic Periodontitis
Interventions: DRUG: placebo|DRUG: Rosuvastatin|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PCI-32765 (Ibrutinib) in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-cell Prolymphocytic Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Prolymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory/Relapsed Chronic Lymphocytic Leukemia
Interventions: DRUG: ibrutinib|OTHER: Correlative laboratory samples|OTHER: quality of life assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FSTL1 and PPCs on Pediatric Within LDLT:a Prospective Cohort Analysis
Status: NOT_YET_RECRUITING
Conditions: Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)|Pulmonary Complication|Liver Transplant; Complications
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Bioequivalence of Pimecrolimus Cream 1% and Elidel R in Treatment of Mild to Moderate Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: pimecrolimus cream 1%|DRUG: Elidel (pimecrolimus) cream 1%|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke
Status: RECRUITING
Conditions: Stroke
Interventions: DEVICE: Real Ischemic Conditioning|DEVICE: Sham Ischemic Conditioning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus
Status: COMPLETED
Conditions: Neuropsychiatric Systemic Lupus Erythematosus
Interventions: PROCEDURE: Magnetic Resonance Angiography (MRA)|PROCEDURE: Magnetic resonance imaging|PROCEDURE: MRA|PROCEDURE: MRA|PROCEDURE: diffusion Imaging|PROCEDURE: perfusion imaging.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging
Status: COMPLETED
Conditions: Amphetamine-Related Disorders|Amphetamine Abuse
Interventions: DRUG: dexfenfluramine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments
Status: COMPLETED
Conditions: Pregnancy|Miscarriage Less Than 12 Gestational Weeks|Extrauterine Pregnancy|Preeclampsia|Intrauterine Fetal Growth Restriction
Interventions: DRUG: Acetylsalicylic acid|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Imaging Inflammation in Patients With Parkinson's Disease Dementia or Dementia With Lewy Bodies
Status: COMPLETED
Conditions: Diffuse Lewy Body Disease|Dementia With Lewy Bodies|Parkinson's Disease Dementia
Interventions: DRUG: 11C-PBR28
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial for Evaluating Sage-Based Mouthrinse
Status: COMPLETED
Conditions: Stomal Bleeding|Stomatitis, Denture|Tooth Staining|Satisfaction
Interventions: OTHER: Dr. Hauschka Med Mundspüllösung Salbei / cosmetics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of the Effectiveness of Stretching and Strengthening Exercises in Patients With Frozen Shoulder
Status: NOT_YET_RECRUITING
Conditions: Frozen Shoulder
Interventions: PROCEDURE: Stretching Exercises|PROCEDURE: Strengthening Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 18FDG- PET/CT Contribution to the Assessment of Lesion Severity in Cystic Fibrosis (CF)
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: PROCEDURE: PET-CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized Trial Comparing "Push" Versus "Pull" Technology for Mobilizing Pain Evidence Into Practice Across Different Health Professions
Status: COMPLETED
Conditions: Pain
Interventions: BEHAVIORAL: Push + Pull|BEHAVIORAL: Pull
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Chemotherapy Followed by Donor White Blood Cells Plus Interleukin-2 in Treating Patients With Acute Myeloid or Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: filgrastim|BIOLOGICAL: therapeutic allogeneic lymphocytes|DRUG: cytarabine|DRUG: etoposide|DRUG: fludarabine phosphate|DRUG: methotrexate|DRUG: mitoxantrone hydrochloride|DRUG: therapeutic hydrocortisone|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Probiotic Modulation of Intestinal Microbiota in Long-term Intake of Proton Pump Inhibitors
Status: COMPLETED
Conditions: Patients on Long-term Proton Pump Inhibitor Therapy
Interventions: DIETARY_SUPPLEMENT: OMNI-BiOTiC PPI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Compare Endotracheal Tube (ET) With Subglottic Suction Drainage and Standard ET in the Incidence of VAP
Status: COMPLETED
Conditions: Ventilator-Associated Pneumonia
Interventions: DEVICE: SSD tube
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Refitting Somofilcon A Sphere Contact Lens Wearers Into Fanfilcon A Sphere Lenses for 4-Weeks of Wear
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: somofilcon A contact lens|DEVICE: fanfilcon A contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With EPI Vaccines
Status: COMPLETED
Conditions: Hand, Foot and Mouth Disease
Interventions: BIOLOGICAL: Concomitant administration of EV71 vaccine with EPI vaccines|BIOLOGICAL: Single injection of EPI vaccine|BIOLOGICAL: EV71 Vaccine only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: HDI Versus Chemotherapy as Systemic Adjuvant Therapy for Resected Mucosal Melanoma
Status: UNKNOWN
Conditions: Melanoma
Interventions: DRUG: Temozolomide Plus Cisplatin|DRUG: High-Dose IFN-a2b
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma)
Status: COMPLETED
Conditions: Melanoma
Interventions: DRUG: Nivolumab|DRUG: Ipilimumab|DRUG: RO7247669 2100 mg|DRUG: Atezolizumab|DRUG: Tiragolumab|DRUG: RO7247669 600 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure
Status: UNKNOWN
Conditions: Liver Failure, Acute on Chronic
Interventions: BIOLOGICAL: Mesenchymal Stem Cell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Polyamine Treatment in Elderly Patients With Coronary Artery Disease
Status: RECRUITING
Conditions: Ischemic Heart Disease|Myocardial Infarction|Cardiovascular Diseases|Hypertensive Heart Disease|Hypertension|Diastolic Dysfunction|Obesity|Metabolic Syndrome|Diabetes Mellitus, Type 2|Dietary Habits|Inflammation|Quality of Life|Cognition Disorder|Cognitive Impairment
Interventions: DIETARY_SUPPLEMENT: Spermidine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Double-blind, Randomized, Vehicle- and Comparator-controlled, Multi-center Trial to Evaluate the Efficacy and Safety of LAS41007 in the Treatment of Actinic Keratosis
Status: COMPLETED
Conditions: Actinic Keratosis
Interventions: DRUG: LAS41007|DRUG: LASW1510|DRUG: vehicle of LAS41007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive-Motor Rehabilitation, Stimulant Drugs, and Active Control in the Treatment of ADHD
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: OTHER: Cognitive-Motor Rehabilitation|DRUG: Ritalin|OTHER: Active Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Temporomandibular Disorder (TMD) Pain in Response to Jaw Advancement in People With TMD and Obstructive Sleep Apnea
Status: TERMINATED
Conditions: Myalgia|Apnea, Obstructive Sleep
Interventions: DEVICE: Mandibular advancement splint
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of the Graft-Versus-Host-Disease in Patients After Stem Cell Transplantation With Tacrolimus and Everolimus
Status: TERMINATED
Conditions: Graft vs Host Disease
Interventions: DRUG: Tacrolimus|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase Ⅱ Clinical Trial of Recombinant Corona Virus Disease-19 (COVID-19) Vaccine (Sf9 Cells)
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Two dose regimen|BIOLOGICAL: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Three dose regimen|BIOLOGICAL: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Two dose regimen|BIOLOGICAL: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) & Three dose regimen|BIOLOGICAL: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Two dose regimen|BIOLOGICAL: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Three dose regimen|BIOLOGICAL: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Two dose regimen|BIOLOGICAL: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) & Three dose regimen|BIOLOGICAL: Low-dose placebo (18-59 years) & Two dose regimen|BIOLOGICAL: Low-dose placebo (18-59 years) & Three dose regimen|BIOLOGICAL: High-dose placebo (18-59 years) & Two dose regimen|BIOLOGICAL: High-dose placebo (18-59 years) & Three dose regimen|BIOLOGICAL: Low-dose placebo (60-85 years) & Two dose regimen|BIOLOGICAL: Low-dose placebo (60-85 years) & Three dose regimen|BIOLOGICAL: High-dose placebo (60-85 years) & Two dose regimen|BIOLOGICAL: High-dose placebo (60-85 years) & Three dose regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Brief Motivational Therapy Versus Usual Care for Alcohol Use Disorders in Primary Care.
Status: UNKNOWN
Conditions: Alcohol Use Disorder
Interventions: BEHAVIORAL: Brief motivational treatment|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ice Therapy and Warm Baths for Hemorrhoidectomy Wound Care
Status: ENROLLING_BY_INVITATION
Conditions: Post Hemorrhoidectomy Pain|Post Operative Pain|Wound Heal
Interventions: OTHER: Ice packing|OTHER: Warm sitz bath
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Coffeeberry on Mood and Cognitive Performance
Status: COMPLETED
Conditions: Mental Fatigue|Alertness|Mood|Cognition
Interventions: OTHER: Placebo|DIETARY_SUPPLEMENT: Coffeeberry|DIETARY_SUPPLEMENT: Caffeine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Local Treatment With and Without Sensorimotor and Balance Exercises in Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Local neck treatment (LNT)|OTHER: LNT plus sensorimotor exercises|OTHER: LNT plus balance exercises|OTHER: LNT plus sensorimotor/balance exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Non-small Cell Lung Cancer|Metastatic Non-Small Cell Lung Cancer|NSCLC|KRAS G12C|Metastatic Lung Cancer|Advanced Lung Carcinoma
Interventions: DRUG: BBO-8520|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?
Status: COMPLETED
Conditions: Ketamine Adverse Reaction|Effects of; Anesthesia, Spinal and Epidural, in Pregnancy|Complication of Labor and/or Delivery
Interventions: DRUG: Ketamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Speedlyte and IV Rehydration Treating Children With Gastroenteritis in a Pediatric Emergency Department (ED)
Status: TERMINATED
Conditions: Dehydration|Acute Gastroenteritis
Interventions: OTHER: Standard IV Rehydration Therapy|OTHER: Oral Rehydration Therapy (ORT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Almonds and Health Effects on Metabolism, Vascular Function and Cognition
Status: COMPLETED
Conditions: PreDiabetes|Impaired Glucose Tolerance|Impaired Fasting Glucose|Overweight and Obesity
Interventions: DIETARY_SUPPLEMENT: Almonds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peritoneal Dialysis Pilot Study: Evaluating Polyethylene Glycol (PEG) for Constipation
Status: COMPLETED
Conditions: Constipation|Peritoneal Dialysis Complication
Interventions: DRUG: Current Bowel Protocol (senna/lactulose)|DRUG: PEG Bowel Protocol (PEG/lactulose)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacokinetics (PK), And Hematological Activity Of AMD3100 (Plerixafor) In Subjects With Renal Impairment
Status: COMPLETED
Conditions: Renal Impairment
Interventions: DRUG: plerixafor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient-Derived Xenografts to Reduce Cancer Health Disparities
Status: RECRUITING
Conditions: Bladder Carcinoma|Gastric Carcinoma|Liver and Intrahepatic Bile Duct Carcinoma|Lung Carcinoma|Malignant Neoplasm
Interventions: PROCEDURE: Biospecimen Collection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Conservative Versus Operative Treatment of Displaced Neck Fractures of the Fifth Metacarpal
Status: TERMINATED
Conditions: Fifth Metacarpal Neck Fracture
Interventions: PROCEDURE: antegrade intramedullary splinting|PROCEDURE: conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-Cell Depletion, Donor Hematopoietic Stem Cell Transplant (HSCT), and T-Cell Infusions in Treating Patients With Hematologic Cancer or Other Diseases
Status: TERMINATED
Conditions: Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Multiple Myeloma and Malignant Plasma Cell Neoplasms|Myelodysplastic Syndromes|Precancerous/Nonmalignant Condition|Secondary Myelofibrosis
Interventions: PROCEDURE: peripheral blood lymphocyte therapy|PROCEDURE: allogeneic hematopoietic stem cell transplantation|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: total-body irradiation (TBI)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexamethasone or Clonidine as Adjuncts to Ropivacaine for Caudal Analgesia on Analgesia Duration in Children
Status: UNKNOWN
Conditions: Postoperative Pain
Interventions: DRUG: Dexamethasone|DRUG: Clonidine|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-833923 With Cisplatin and Capecitabine in Inoperable, Metastatic Gastric, Gastroesophageal, or Esophageal Adenocarcinomas
Status: COMPLETED
Conditions: Stomach Neoplasms|Esophageal Neoplasms
Interventions: DRUG: BMS-833923|DRUG: Cisplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children With Prior Treatment
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Ritonavir|DRUG: Nelfinavir mesylate|DRUG: Nevirapine|DRUG: Lamivudine|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Zalcitabine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effects of Manual Therapy Techniques on Hamstring
Status: COMPLETED
Conditions: Muscle Tightness|Muscle Spasm
Interventions: DIAGNOSTIC_TEST: Muscle Strength Test|DIAGNOSTIC_TEST: Hamstring Flexibility|DIAGNOSTIC_TEST: Knee Range of Motion|DEVICE: Percussion Therapy|OTHER: Manual Therapy Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Cryosurgery and NK Immunotherapy for Advanced Liver Cancer
Status: COMPLETED
Conditions: Secondary Malignant Neoplasm of Liver
Interventions: DEVICE: Cryosurgery|BIOLOGICAL: NK Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Instrument-Assisted Soft Tissue Mobilization on Gastrocnemius and Achilles Tendon in Plantar Fasciitis
Status: COMPLETED
Conditions: Plantar Fascitis
Interventions: OTHER: IASTM of Gastrocnemius + Conventional therapy|OTHER: IASTM of AchillesTendon + Conventional Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Role of the Gut Microbiota in Estrogen Metabolism and Dietary Flax as a Potential Modulator.
Status: COMPLETED
Conditions: Menopause
Interventions: DIETARY_SUPPLEMENT: Flaxseed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales
Status: UNKNOWN
Conditions: Postpartum Depressive Mood|Postpartum Sexual Function
Interventions: DRUG: Ethinyl Estradiol 35mcg/Norethindrone 1mg|DRUG: Ethinyl Estradiol 20mcg/Norethindrone 1mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Risk of Sensitisation of the rdESAT-6 + rCFP-10 Skin Test Following Repeated Intradermal Administration
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: rdESAT-6 + rCFP-10
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Infergen, Ribavirin & Avandia in Previous Relapsers or Nonresponders to Pegylated Interferon and Ribavirin
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: rosiglitazone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Abbreviated R-CHOP in Completely Excised Stage I or II DLBCL
Status: UNKNOWN
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: Rituximab plus CHOP Immunochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT