pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Tralokinumab in Combination With Topical Corticosteroids for Moderate to Severe Atopic Dermatitis - ECZTRA 3
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: Tralokinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine
Status: COMPLETED
Conditions: Reducing Psychological Side Effects of Ketamine
Interventions: DRUG: Lamotrigine 300 MG|DRUG: Placebo|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Neuromuscular Electrical Stimulation in Muscle Architecture and Functionality of Patients After Acute Stroke
Status: UNKNOWN
Conditions: Stroke, Acute|Neuromuscular Electrical Stimulation
Interventions: OTHER: Neuromuscular Electrical Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Music on Perioperative Outcomes in Cataract Surgery
Status: COMPLETED
Conditions: Cataract Surgery|Stress Levels|Music Improving Outcomes in Cataract Surgery
Interventions: DEVICE: Sennheiser non-occlusive headphones|DEVICE: Sennheiser non-occlusive headphones without music|OTHER: No Sennheiser non-occlusive headphones
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Insomnia and Mindfulness Stress Reduction Program
Status: COMPLETED
Conditions: Postmenopausal Symptoms
Interventions: OTHER: mindfulness stress reduction program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prescribing Lorazepam for IUD Insertion: Pilot Feasibility Study
Status: NOT_YET_RECRUITING
Conditions: Pain|IUD
Interventions: DRUG: Lorazepam 1 mg|DRUG: Ibuprofen 800 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase I Study of Triciribine Phosphate Monohydrate (TCN-PM, VD-0002) in Adult Subjects With Metastatic Cancer
Status: COMPLETED
Conditions: Cancer
Interventions: DRUG: Triciribine Phosphate Monohydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin
Status: ACTIVE_NOT_RECRUITING
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Head and Neck Squamous Cell Carcinoma|Hypopharyngeal Squamous Cell Carcinoma|Laryngeal Squamous Cell Carcinoma|Oral Cavity Squamous Cell Carcinoma|Oropharyngeal Squamous Cell Carcinoma|Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8|Squamous Cell Carcinoma of Unknown Primary|Stage III Hypopharyngeal Carcinoma AJCC v8|Stage III Laryngeal Cancer AJCC v8|Stage III Lip and Oral Cavity Cancer AJCC v8|Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVA Hypopharyngeal Carcinoma AJCC v8|Stage IVA Laryngeal Cancer AJCC v8|Stage IVA Lip and Oral Cavity Cancer AJCC v8|Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8|Stage IVB Hypopharyngeal Carcinoma AJCC v8|Stage IVB Laryngeal Cancer AJCC v8|Stage IVB Lip and Oral Cavity Cancer AJCC v8|Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions: BIOLOGICAL: Cetuximab|BIOLOGICAL: Durvalumab|RADIATION: Intensity-Modulated Radiation Therapy|OTHER: Laboratory Biomarker Analysis|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Chemoprevention Approaches for School-based Malaria Control
Status: COMPLETED
Conditions: Malaria,Falciparum|Anemia in Children
Interventions: DRUG: Dihydroartemisinin-Piperaquine|DRUG: Chloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety, Tolerability and Pharmacokinetics of Repeat Doses of GSK1014802.
Status: COMPLETED
Conditions: Bipolar Depression|Bipolar Disorder
Interventions: DRUG: Placebo|DRUG: GSK1014802
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Central Arterial Pressure of Normotensive Women Taking Nifedipine for Tocolysis
Status: WITHDRAWN
Conditions: Tocolysis With Nifedipine
Interventions: OTHER: Nifedipine for tocolysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Assessing the Efficacy of Enhanced Versus Standard 3D Training Models in Laparoscopic Skills Acquisition: A Randomised Controlled Trial
Status: COMPLETED
Conditions: Laparoscopic Skills Acquisition
Interventions: OTHER: 3D-Enhanced Training Models|OTHER: Standard 3D LapPass Training Models
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Trastuzumab and Gefitinib in Treating Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Male Breast Cancer|Recurrent Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: gefitinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stage I/II NSCLC Perioperative Chemotherapy
Status: COMPLETED
Conditions: Non-small Cell Lung Cancer Stage I and II|Peri-operative Chemotherapy
Interventions: DRUG: gemcitabine + cisplatine|DRUG: Paclitaxel + Carboplatine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fentanyl Sublingual Spray in Treating Opioid-tolerant Cancer Patients With or Without Oral Mucositis
Status: COMPLETED
Conditions: Mucositis|Pain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Fentanyl sublingual spray
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: 12 Week Evaluation of the Safety and Efficacy of 4 Dosing Strategies of CP-526,555 and Placebo for Smoking Cessation.
Status: COMPLETED
Conditions: Smoking Cessation
Interventions: DRUG: CP-526,555 (varenicline)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Efficacy and Safety of the Combination of Reduced Duration Prophylaxis Followed by Immuno-guided Prophylaxis in Lung Transplant Recipients.
Status: COMPLETED
Conditions: Transplantation Infection|Cytomegalovirus Infections
Interventions: DRUG: Valganciclovir|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sunitinib Malate Related Fatigue in Patients With Metastatic Kidney Cancer
Status: TERMINATED
Conditions: Fatigue|Recurrent Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: PROCEDURE: transcranial magnetic stimulation|PROCEDURE: electromyography|OTHER: survey administration|DRUG: sunitinib malate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Nivolumab in Treating Patients With Primary Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis, or Post-Polycythemia Vera Myelofibrosis
Status: TERMINATED
Conditions: Hepatomegaly|Myelofibrosis Transformation in Essential Thrombocythemia|Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase|Primary Myelofibrosis|Splenomegaly
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Nivolumab|OTHER: Quality-of-Life Assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Vigorous Versus Low Intensity Cool Room Treadmill Training in People With Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Neurological Rehabilitation|Exercise|Neuronal Plasticity|Cooling
Interventions: OTHER: Body-weight supported treadmill training in a room cooled to 16°C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Clinical Efficacy and Safety of Dapoxetine, Combined Dapoxetine With Folic Acid and Combined Dapoxetine With Vitamin B12 in Treatment of Patients With Premature Ejaculation
Status: COMPLETED
Conditions: Premature Ejaculation
Interventions: DRUG: Multi-Vitamin Tablets|DRUG: Dapoxetine|DRUG: Dapoxetine and folic acid.|DRUG: Dapoxetine and vitamin B12
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Parsaclisib in Newly Diagnosed Stage I-IIIC Triple Negative or HER2+ Breast Cancer
Status: WITHDRAWN
Conditions: Breast Cancer|Breast Neoplasms|Triple Negative Breast Cancer|HER2-positive Breast Cancer
Interventions: DRUG: Parsaclisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: RCT of Home-based vs Formal Physical Therapy for Treatment of New Onset Non-insertional Achilles Tendinopathy
Status: NOT_YET_RECRUITING
Conditions: Achilles Tendinopathy
Interventions: OTHER: Home-based Exercise Protocol|OTHER: Formal Physical Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intracranial Hemorrhage Risk of Intensive Statin in Acute Ischemic Stroke With Cerebral Microbleeds
Status: NOT_YET_RECRUITING
Conditions: Acute Ischemic Stroke|Cerebral Microbleeds
Interventions: DRUG: Atorvastatin Calcium tablets 80mg|DRUG: Atorvastatin Calcium tablets 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Ixazomib and Dexamethasone Versus Ixazomib, Dexamethasone and Lenalidomide, Randomized With NFKB2 Rearrangement
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma
Interventions: DRUG: Dexamethasone|DRUG: Ixazomib|DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
Status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Cancer
Interventions: DRUG: carboplatin|DRUG: cisplatin|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alemtuzumab and CHOP in T-cell Lymphoma
Status: COMPLETED
Conditions: Lymphoma, T-Cell, Peripheral
Interventions: DRUG: CHOP14 chemotherapy (cyclophosphamide, hydroxydaunorubicin, vincristin, prednison) plus G-CSF, combined with alemtuzumab|DRUG: CHOP14 chemotherapy (see specification under Arm B) plus G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate
Status: RECRUITING
Conditions: Benign Prostatic Hyperplasia With Outflow Obstruction|Urinary Retention|Lower Urinary Tract Symptoms
Interventions: BEHAVIORAL: Preoperative pelvic floor physical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Anxiolytic Effectiveness of Virtual Reality Glasses in Surgery
Status: RECRUITING
Conditions: Anesthesia|Anxiety|Postoperative Pain|Postoperative Recovery
Interventions: DEVICE: Oculus Quest 2 VR virtual reality glasses and wired over-ear headphones|OTHER: No VR
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer
Status: TERMINATED
Conditions: Lung Cancer|Small Cell Lung Cancer|Solid Tumors|Extensive-stage Small Cell Lung Cancer
Interventions: DRUG: AMG 479|DRUG: Etoposide|DRUG: Placebo|DRUG: AMG 102|DRUG: Carboplatin|DRUG: Cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Influence of Luteolin on Memory in Healthy Subjects
Status: TERMINATED
Conditions: Memory
Interventions: DIETARY_SUPPLEMENT: Luteolin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different Formulations
Status: COMPLETED
Conditions: Healthy Participants
Interventions: DRUG: PF-06700841 Immediate release tablets|DRUG: PF-06700841 Modified release tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pilot Study to Measure Lung Biopsy Diagnostic Yield Using Always On Electromagnetic Tip Tracked Devices
Status: WITHDRAWN
Conditions: Pulmonary Coin Lesion
Interventions: PROCEDURE: Lung biopsy using Always On EM Tip Tracked Device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study of Sitagliptin in Patients With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Diet/Exercise Therapy (0431-054)(COMPLETED)
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-Insulin-Dependent
Interventions: DRUG: sitagliptin phosphate|DRUG: Comparator: voglibose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Oltipraz in the Patients With Non-alcoholic Fatty Liver Disease
Status: COMPLETED
Conditions: Non-alcoholic Fatty Liver Disease
Interventions: DRUG: Placebo|DRUG: Oltipraz
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dual Anti-Platelet Therapy in Patients With Coronary Multi-Vessel Disease (DAPT-MVD)
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Artery Disease|Myocardial Ischemia|Acute Coronary Syndrome|Heart Diseases|Syndrome Heart Disease|Cardiovascular Diseases|Arteriosclerosis|Arterial Occlusive Diseases|Coronary Disease|Vascular Diseases
Interventions: DRUG: Clopidogrel and Aspirin dual-antiplatelet therapy|DRUG: Aspirin monotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
Status: RECRUITING
Conditions: Labor Pain
Interventions: DRUG: Epidural analgesia with bupivacaine and dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Evaluation of Safety and Efficacy of the Bifurcated Multilayer Flow Modulator (BMFM®).
Status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal|Aortic Aneurysm, Thoracoabdominal
Interventions: DEVICE: Implantation of the Bifurcated Multilayer Flow Modulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Medications for the Management of Acute Migraine Headache in the Emergency Department
Status: NOT_YET_RECRUITING
Conditions: Acute Migraine Headache
Interventions: DRUG: Oral metoclopramide and ibuprofen|DRUG: Intravenous metoclopramide and ketorolac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of β-glucans on Gut Permeability and Microbiota in Elderly
Status: COMPLETED
Conditions: Elderly|Bowel Symptoms|Prebiotics
Interventions: DIETARY_SUPPLEMENT: yeast-beta glucan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Avelumab for People With Recurrent Respiratory Papillomatosis
Status: COMPLETED
Conditions: Recurrent Respiratory Papillomatosis|Juvenile Laryngeal Papilloma|Laryngeal Papilloma, Recurrent|Respiratory Papillomatosis|Human Papilloma Virus
Interventions: DRUG: Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acetaminophen for Cancer Pain
Status: COMPLETED
Conditions: Cancer|Pain
Interventions: DRUG: Acetaminophen|DRUG: acetaminophen|DRUG: placebo, sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Azacitidine Combined With Chidamide (VAC) for the Treatment of Newly Diagnosed Acute Monocytic Leukemia
Status: RECRUITING
Conditions: Acute Monocytic Leukemia|Newly Diagnosed
Interventions: DRUG: Chidamide|DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brief Nurse-led Mindfulness Based Intervention
Status: COMPLETED
Conditions: Pain|Osteoarthritis, Knee|Osteoarthritis, Hip
Interventions: BEHAVIORAL: Nurse-led Mindfulness Based Intervention|BEHAVIORAL: Nurse-led Pain Psychoeducation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (NATROX™) on the Rates of Healing of Chronic Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Non-healing Wound
Interventions: DEVICE: NATROX™ Topical Oxygen Therapy System
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Plasma-Lyte 148® versUs Saline Study
Status: COMPLETED
Conditions: Hypovolemia
Interventions: DRUG: Plasma-Lyte 148®|DRUG: 0.9% sodium chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Implementation of the MAINTAIN Instrument for Patients With Dysfunctional Spinal Pain
Status: RECRUITING
Conditions: Low Back Pain, Recurrent|Neck Pain|Back Pain
Interventions: OTHER: Chiropractic maintenance care|OTHER: Standard chiropractic care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I/II Study of IXO With Bevacizumab in Patients With Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: IXO regimen + bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Diabetic Foot Ulcers
Status: COMPLETED
Conditions: Diabetic Foot Ulcers
Interventions: DRUG: Granexin® gel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Study of Clinical Outcomes Following a Single Intradiscal Injection of Bone Marrow Aspirate Concentrate (BMAC) for Single Level Discogenic Low Back Pain
Status: UNKNOWN
Conditions: Degenerative Disc Disease|Spine Degeneration
Interventions: OTHER: Autologous Bone Marrow Aspirate Concentrate (BMAC) Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Microcirculation in Perforator Flaps. Enhancing Tissue Survival
Status: UNKNOWN
Conditions: Reconstructive Surgery|Microcirculation
Interventions: DRUG: Indocyanine green (ICG)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: T-Cell Therapy (ECT204) in Adults With Advanced HCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma|Liver Cancer, Adult|Liver Neoplasm|Metastatic Liver Cancer
Interventions: BIOLOGICAL: ECT204 T cells|DRUG: Regorafenib (STIVARGA®, BAY73-4506)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population
Status: UNKNOWN
Conditions: Polymorphism (Genetics)|Endometriosis
Interventions: GENETIC: SNPs analysis with Sanger sequencing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase II Study of AZD9291 in Advanced Stage NSCLC With EGFR and T790M Mutations Detected in Plasma Ct-DNA
Status: UNKNOWN
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: AZD9291
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Trial for Hepatocellular Carcinoma Adjuvant Treatment by Lipiocis
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Hepatitis, Viral, Human
Interventions: DRUG: 131 I-lipiodol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Infectious Vulvovaginitis on Wound Complication Rates After Vulvar Excision for Premalignant Lesions
Status: NOT_YET_RECRUITING
Conditions: Vaginitis|Vulvar Diseases
Interventions: DIAGNOSTIC_TEST: vaginitis panel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma
Status: UNKNOWN
Conditions: Intracranial Germinoma
Interventions: DRUG: Carboplatin|DRUG: Etoposide|DRUG: Cyclophosphamide|DRUG: Bleomycin|RADIATION: Reduced dose of radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01)
Status: UNKNOWN
Conditions: Sepsis|Septic Shock|Hematologic Malignancy|Tumor|Allogeneic Stem Cell Transplantation
Interventions: DRUG: Aminoglycosides intervention|BEHAVIORAL: Lack of protective isolation intervention|OTHER: No systematic aminoglycosides intervention - standard arm|OTHER: Protective isolation intervention - standard arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Clinical Effectiveness of Intravitreal Bevacizumab (Lumiere®) in Patients With Wet Age-related Macular Degeneration (Wet AMD)
Status: COMPLETED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Bevacizumab (Lumiere®)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Quizartinib and Omacetaxine Mepesuccinate for AML Carrying FLT3-ITD
Status: UNKNOWN
Conditions: AML|FLT3-ITD Mutation
Interventions: DRUG: Quizartinib|DRUG: Omacetaxine Mepesuccinate Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Impact of Maximal Strength Training in Patients With COPD
Status: RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Maximal strenght training (MST) plus endurance training (ET)|OTHER: Endurance training (ET)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of Intraperitoneal Carboplatin With IV Paclitaxel and Bevacizumab in Untreated Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer|Fallopian Tube Cancer|Primary Peritoneal Cancer|No Prior Chemotherapy
Interventions: DRUG: Paclitaxel|DRUG: Carboplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fasting-mimicking Diet and Longevity Diet, Body Composition and Aging
Status: RECRUITING
Conditions: Overweight|Risk Behavior|Obesity
Interventions: BEHAVIORAL: Fasting-mimicking diet (FMD)|BEHAVIORAL: Longevity Diet (LD) + Fasting-mimicking Diet (FMD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rivastigmine Patch Effect on the Post-operative Delirium in Patients at Risk of Dementia.
Status: COMPLETED
Conditions: Delirium
Interventions: DRUG: Rivastigmine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Beta 3 Agonist Treatment in Heart Failure-2
Status: COMPLETED
Conditions: Heart Failure With Reduced Ejection Fraction NYHA Class III-IV
Interventions: DRUG: Mirabegron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Japanese Pediatric H5N1 Vaccine Study
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: H5N1 (Pre-)Pandemic Influenza Vaccine (Whole Virion, Vero Cell-Derived, Inactivated)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Interleaving Stimulation Improves Dyskinesia in Parkinson's Disease
Status: RECRUITING
Conditions: Parkinson's Disease
Interventions: DEVICE: interleaving stimulation|DEVICE: empirical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical and Dermoscopic Comparison of Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriasis Patients' Nails
Status: COMPLETED
Conditions: Psoriasis Circinata|Psoriatic Arthritis|Rheumatoid Arthritis|Spondylarthropathies|Psoriatic Nail
Interventions: DIAGNOSTIC_TEST: Dermoscopic examination
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison Of Celecoxib 200 Mg Bid, Loxoprofen Sodium 60 Mg Tid And Placebo In Low Back Pain In Japan
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DRUG: Celecoxib|DRUG: Placebo|DRUG: Loxoprofen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: 3-arm Trial to Evaluate Pasireotide LAR/Everolimus Alone/in Combination in Patients With Lung/Thymus NET - LUNA Trial
Status: COMPLETED
Conditions: Neuroendocrine Carcinoma of the Lung and Thymus
Interventions: DRUG: Pasireotide LAR|DRUG: Everolimus|DRUG: Pasireotide LAR and Everolimus Combination
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Women's Ischemia Syndrome Evaluation (WISE)
Status: COMPLETED
Conditions: Angina Pectoris|Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia
Interventions: PROCEDURE: Angiography, MRI, Dobutamine-Stress Echocardiography, PET,|PROCEDURE: Myocardial Contrast Echo, Coronary Flow and Vasomotor Testing
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Pseudoexfoliation Syndrome, Sarcopenia and Chronic Pain
Status: COMPLETED
Conditions: Sarcopenia|Pseudoexfoliation Syndrome
Interventions: DIAGNOSTIC_TEST: SARC-F questionnaire|DIAGNOSTIC_TEST: Gait speed|DIAGNOSTIC_TEST: The chair rise test|DIAGNOSTIC_TEST: Grip strength|DIAGNOSTIC_TEST: Visual analog scale
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CDH - Optimisation of Neonatal Ventilation
Status: UNKNOWN
Conditions: Congenital Diaphragmatic Hernia
Interventions: DEVICE: Measurement of PTPdi|DEVICE: TTV at 4ml/kg|DEVICE: TTV at 5ml/kg|DEVICE: TTV at 6ml/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Dabrafenib +/- Trametinib in Combination With Ipilimumab for V600E/K Mutation Positive Metastatic or Unresectable Melanoma
Status: COMPLETED
Conditions: Solid Tumours
Interventions: DRUG: Dabrafenib|DRUG: Trametinib|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Leucine on Carnitine Transport to Skeletal Muscle
Status: COMPLETED
Conditions: Muscle Loss
Interventions: DIETARY_SUPPLEMENT: L-carnitine|DIETARY_SUPPLEMENT: L-leucine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Determining the Effects of Sexual Health Education and Counseling Given to Women in the Postpartum Period Based on the EX-PLISSIT Model on Sexual Life
Status: RECRUITING
Conditions: Sexuality|Nurse's Role|Postpartum Disorder
Interventions: OTHER: EX-PLISSIT MODEL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: FIT Families Multicomponent Obesity Intervention for African American Adolescents
Status: RECRUITING
Conditions: Obesity, Childhood|Metabolic Syndrome
Interventions: BEHAVIORAL: FIT|BEHAVIORAL: Home-Based Family Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Low vs. Air Oxygen Concentration CAPA-IVM Culture of Cumulus-oocyte Complexes
Status: COMPLETED
Conditions: IVM|PCOS (Polycystic Ovary Syndrome)
Interventions: OTHER: The way of Cumulus-oocyte complexes (COC) CAPA-IVM culture condition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline
Status: COMPLETED
Conditions: Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: ProdromeNeuro Omega 3 Oil Nutritional Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of 18 F-FP-DTBZ Pancreatic PET Scanning as a Tool to Measure Beta Cell Mass
Status: COMPLETED
Conditions: Healthy Volunteers|Diabetes Mellitus, Type 1
Interventions: DRUG: 18 F-FP-DTBZ|RADIATION: PET Scanning
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Breathing Exercises in Addition to Conventional Treatment in Frozen Shoulder Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Frozen Shoulder|Pain|Quality of Life
Interventions: OTHER: Breathing Exercises|OTHER: Conventional treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Observation of Acute Cardiopulmonary Effects in Healthy Individuals Performing Cardiopulmonary Exercise Test (CPX) During Whole Body Vibration (WBV)
Status: UNKNOWN
Conditions: Acute Cardiopulmonary Effects
Interventions: OTHER: Observational study to evaluate acute cardiopulmonary effects of whole body vibration (WBV) on healthy individuals analysed in non-invasive cardiopulmonary exercise test (CPX).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Prospective Evaluation of RINCE to Reduce Fibromyalgia Effects - St. Joseph Mercy Oakland
Status: COMPLETED
Conditions: Fibromyalgia
Interventions: DEVICE: RINCE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Traditional Chinese Medicine (GSJYF) in Children With Inherited Proteinuric Kidney Disease
Status: RECRUITING
Conditions: Proteinuria|Kidney Diseases|Hereditary Nephropathy
Interventions: DRUG: TCM+ Routine Therapy|DRUG: Routine Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Lung Ultrasound as a Method to Measure Changes in Extravascular Lung Water Induced by Positional Changes (LUPE)
Status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Interventions: OTHER: Methodology
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Development and Pilot Test of an Elective Bilateral Salpingo-Oophorectomy (BSO) Decision Support Guide
Status: COMPLETED
Conditions: Surgical Procedure, Unspecified
Interventions: BEHAVIORAL: Computerized decision aid with 1 type of value clarification
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Effects of Railway Vibration on Sleep and Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Noise Exposure|Sleep Disturbance|Sleep Hygiene|Metabolic Disturbance|Cognitive Change|Glucose Metabolism Disorders (Including Diabetes Mellitus)|Vibration; Exposure
Interventions: RADIATION: Railway noise|RADIATION: Low level railway vibration|RADIATION: Intermediate level railway vibration|RADIATION: High level railway vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison in Pulmonary Compliance Between Curosurf and Survanta in Preterm Infants With Respiratory Distress Syndrome
Status: WITHDRAWN
Conditions: Respiratory Distress Syndrome
Interventions: DRUG: Curosurf®|DRUG: Survanta®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Cycle Study: a Study of the Effectiveness of Cycling Exercise in Breaking the Cycle of Pregnancy Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: BEHAVIORAL: Supervised home-based exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI
Status: NOT_YET_RECRUITING
Conditions: Behavior and Behavior Mechanisms
Interventions: OTHER: TMS or tES|OTHER: sham TMS or tES
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Thulium Laser and Topical Platelet Rich Plasma (PRP) vs. PRP Injection for the Treatment of Male Androgenetic Alopecia
Status: WITHDRAWN
Conditions: Androgenetic Alopecia
Interventions: DEVICE: Fractionated Thulium laser|PROCEDURE: Autologous Platelet Rich Plasma Injection|PROCEDURE: Autologous Platelet Rich Plasma Topical Application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: AT7519M
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Her2 and TGFBeta Cytotoxic T Cells in Treatment of Her2 Positive Malignancy
Status: COMPLETED
Conditions: HER2 Positive Malignancies
Interventions: BIOLOGICAL: TGFBeta resistant HER2/EBV-CTLs
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness
Status: COMPLETED
Conditions: Bipolar Disorder|Schizophrenia|Major Depressive Disorder|Chronic Affective Disorders|Cardiovascular Disease Risk
Interventions: BEHAVIORAL: Life Goals Collaborative Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Transapical Beating-Heart Septal Myectomy in Patients With Symptomatic Nonobstructive Hypertrophic Cardiomyopathy
Status: RECRUITING
Conditions: Nonobstructive Hypertrophic Cardiomyopathy
Interventions: PROCEDURE: Transapical beating-heart septal myectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Modified Bortezomib-based Combination Therapy for Multiple Myeloma
Status: UNKNOWN
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Doxorubicin|DRUG: Cyclophosphamide|DRUG: Mitoxsnteone|DRUG: Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Avastin (Bevacizumab) and Sequential Chemotherapy in Patients With Primary HER2 Negative Operable Breast Cancer.
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: bevacizumab [Avastin]|DRUG: Docetaxel|DRUG: Standard chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants
Status: COMPLETED
Conditions: Tooth Extraction|Dental Implants
Interventions: PROCEDURE: Concentrated Growth Factors (CGF)|PROCEDURE: Platelet-Rich Fibrin (PRF)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluates the Safety and Efficacy of WX-0593 in ALK -Positive, or ROS1-positive Non-small Cell Lung Cancer
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: DRUG: WX-0593 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of High Dose Interleukin-2 (IL-2) and Stereotactic Body Radiation (SBRT) in Patients With Metastatic Renal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Renal Cell Carcinoma
Interventions: BIOLOGICAL: High Dose IL-2|RADIATION: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AG Combined With Immunotherapy and SBRT in Patients With Potentially Resectable Pancreatic Cancer
Status: NOT_YET_RECRUITING
Conditions: Pancreatic Carcinoma
Interventions: DRUG: Toripalimab|DRUG: Gemcitabine|DRUG: Nab paclitaxel|OTHER: SBRT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose-ranging Study of Tranexamic Acid in Valve Surgery
Status: COMPLETED
Conditions: Hemorrhage|Valvular Heart Surgery
Interventions: DRUG: Tranexamic Acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pre-workout Supplement Versus Caffeine on Energy Expenditure.
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: ENGN Shred|DIETARY_SUPPLEMENT: Nutricost caffeine powder|DIETARY_SUPPLEMENT: Crystal Light
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PROPHYLACTIC ANTIBIOTICS PRIOR TO CESAREAN SECTION IN OBESE WOMEN
Status: COMPLETED
Conditions: Infection Prevention
Interventions: DRUG: Cefazolin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Type 1 Diabètes Adults With Hypoglycemia Unawareness and Documented Nocturnal Hypoglycemia
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: Overnight intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Induction Therapy for Patients With FLT3 Mutated Acute Myeloid Leukemia
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: CPX-351|DRUG: Midostaurin|DRUG: Busulfan|DRUG: Melphalan|DRUG: Fludarabine|BIOLOGICAL: CD34+ selected allogeneic stem cell transplant from an HLA-compatible donor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell Disease
Status: COMPLETED
Conditions: Ulcer|Anemia|Sickle Cell Disease
Interventions: DIAGNOSTIC_TEST: patients with limb ulcers|DIAGNOSTIC_TEST: For patients without limb ulcers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism
Status: COMPLETED
Conditions: Primary Aldosteronism|Adrenal Adenoma
Interventions: DEVICE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: The International Diabetes Closed Loop (iDCL) Trial: Clinical Acceptance of the Artificial Pancreas (DCLP3 Extension)
Status: COMPLETED
Conditions: Type 1 Diabetes Mellitus
Interventions: DEVICE: t:slim X2 with Control-IQ Technology & Dexcom G6 CGM|DEVICE: t:slim X2 with Basal-IQ & Dexcom G6 CGM
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: LDR Brachytherapy Versus SBRT for Low and Intermediate Risk Prostate Cancer Patients
Status: UNKNOWN
Conditions: Prostate Cancer
Interventions: RADIATION: Hypofractionated RT 5 x 7,25 Gy|RADIATION: LDR-brachytherapy with I125 seeds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neovac 2 Burkina Faso: Impact of the Integration of Hepatitis B Birth Dose Vaccine Into the Infant Immunization Schedule
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: birth dose vaccination against hepatitis B strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vaginal vs. Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Uterine Fibroids|Uterine Leiomyoma|Abnormal Uterine Bleeding, Unspecified
Interventions: PROCEDURE: Hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Amifampridine Phosphate in Patients With MuSK-MG
Status: COMPLETED
Conditions: Myasthenia Gravis, Generalized
Interventions: DRUG: Amifampridine Phosphate|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Dextrose Injection for Osgood-Schlatter Disease
Status: COMPLETED
Conditions: Osgood-Schlatter Disease
Interventions: PROCEDURE: Dextrose Injection|PROCEDURE: Lidocaine Injection|OTHER: Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: PF 06412562 in Subjects With Advanced Stage Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: DRUG: PF-06412562|DRUG: Standard of Care Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Enteral Docosahexaenoic Acid Administration in Children With Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Malnutrition
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic acid (DHA)|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of Combination of CPGJ602 and Chemotherapy, in First Line, With Wild KRAS/NRAS/BRAF in Metastatic Colorectal Cancer
Status: UNKNOWN
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: CPGJ602|DRUG: cetuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT