pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Trametinib in Combination With Paclitaxel in the Treatment of Anaplastic Thyroid Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Anaplastic Thyroid Cancer
Interventions: DRUG: Trametinib|DRUG: Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HAART Adherence Among HIV-infected Persons and the Factors Affecting Treatment Adherence
Status: COMPLETED
Conditions: Acute HIV Infection|Acquired Immunodeficiency Syndrome|Medication Adherence
Interventions: BEHAVIORAL: Advanced Adherence Counseling (AdvAdh)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Music Therapy Video Development in Improving Communication, Emotional Distress, and Recovery in Adolescents/Young Adults Undergoing Treatment for High-Risk Cancer and Their Parents
Status: COMPLETED
Conditions: Malignant Neoplasm
Interventions: OTHER: Caregiver-Related Intervention or Procedure|PROCEDURE: Music Therapy|PROCEDURE: Music Therapy|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of a New Infant Cereal on Weight Gain
Status: COMPLETED
Conditions: Infant Development
Interventions: DIETARY_SUPPLEMENT: New Infant Cereal|DIETARY_SUPPLEMENT: Standard Infant Cereal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Imatinib, Bevacizumab, and Cyclophosphamide in Patients With Refractory Metastatic Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor
Interventions: BIOLOGICAL: bevacizumab|DRUG: cyclophosphamide|DRUG: imatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioimpedance as a Diagnostic Tool for Assessing the Need for Socket Modification in Transtibial Amputees
Status: COMPLETED
Conditions: Transtibial Amputee
Interventions: DEVICE: Bioimpedance monitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare PK, PD and Safety of the AD-206 and Esomeprazole
Status: COMPLETED
Conditions: Gastritis
Interventions: DRUG: AD-206 20mg|DRUG: Esomeprazole 20mg|DRUG: AD-206 40mg|DRUG: Esomeprazole 40mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Male Involvement in Family Planning Education on Contraceptive Use
Status: COMPLETED
Conditions: Contraceptive Usage|Family Planning
Interventions: BEHAVIORAL: Couples arm|BEHAVIORAL: Male arm
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: AcoArt Ⅰ / SFA China
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: DEVICE: drug eluting balloon catheter (trade name: Orchid)|DEVICE: common percutaneous transluminal angioplasty balloon catheter (trade name: Admiral)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Microvascular Dilatation After Endogenous Induced Hyperinsulinemia
Status: COMPLETED
Conditions: Hypertension|Obesity
Interventions: DIETARY_SUPPLEMENT: Glucose solution|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Minimal Invasive Volar Plating Versus Cast Immobilization for Treatment of Stable Non-displaced Distal Radial Fractures.
Status: RECRUITING
Conditions: Radius Fracture Distal
Interventions: PROCEDURE: Minimal invasive volar plating
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplantation Using a Non-myeloablative Preparative Regimen of Total Lymphoid Irradiation and Anti-thymocyte Globulin for Older Patients With Relapsed Lymphoid Malignancies
Status: COMPLETED
Conditions: Haemato-lymphoid Malignancies or Syndromes in Whom Allogeneic Stem Cell Transplantation is Warranted
Interventions: DRUG: total lymphoid irradiation and anti-thymocyte globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Evaluating Orally Administered AMG 900 in Adult Subjects With Acute Myeloid Leukemia
Status: COMPLETED
Conditions: Cancer|Hematologic Malignancies|Leukemia|Myeloid Leukemia
Interventions: DRUG: Arm 1- Dose Escalation|DRUG: Arm 2- Dose Expansion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate Safety and Tolerability of NDX-3315 and NDX-3324 in Healthy Participants and Patients With Eosinophilic Esophagitis
Status: RECRUITING
Conditions: Eosinophilic Esophagitis
Interventions: DRUG: NDX-3315 and NDX-3324
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Refractory Overactive Bladder: Sacral NEuromodulation v. BoTulinum Toxin Assessment (ROSETTA)
Status: COMPLETED
Conditions: Urinary Incontinence, Urge
Interventions: DEVICE: InterStim® device|DRUG: Botox® injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Adiposity on Hepatic and Peripheral Insulin Resistance in Type 1 Diabetes
Status: TERMINATED
Conditions: Type1 Diabetes Mellitus|Adiposity
Interventions: PROCEDURE: Euglycemic hyperinsulinemic clamp with tracer enhancement|PROCEDURE: Euglycemic hyperinsulinemic clamp with tracer enhancement
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of a Targeted Video Intervention on Beliefs Regarding Hypertension
Status: COMPLETED
Conditions: Hypertension
Interventions: OTHER: 24-minute video episode of patient education TV sitcom "White Coats"|OTHER: Placebo video
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Real World Expanded Multicenter Study of the MitraClip® System (REALISM)
Status: COMPLETED
Conditions: Mitral Valve Insufficiency|Mitral Valve Regurgitation|Mitral Valve Incompetence|Mitral Regurgitation|Mitral Insufficiency
Interventions: DEVICE: MitraClip® implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Cherry Juice on Fat Oxidation and Cardio-metabolic Markers
Status: COMPLETED
Conditions: Healthy|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Montmorency Tart Cherry Juice|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Evaluation of Different Analysis Methods for Circulating Tumor Cells, Circulating Endothelial Cell, and Circulating Tumor DNA in Patient Followed for a Tumoral Pathology
Status: UNKNOWN
Conditions: Solid Tumor.
Interventions: PROCEDURE: Blood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: 18-FLT PET/MR Imaging to Predict Graft Failure and GVHD in Bone Marrow Transplant Patients
Status: TERMINATED
Conditions: Graft Vs Host Disease
Interventions: DRUG: Fluorothymidine (FLT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Split-face Tolerability Comparison Between Adapalene-Benzoyl Peroxide Gel Versus Tretinoin Gel
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Epiduo Gel|DRUG: Retin-A Micro Microsphere 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Fluid Leakage Past Tracheal Tube Cuff : Effect of Suctioning Manoeuvre
Status: COMPLETED
Conditions: Deep Sedation|Respiration, Artificial
Interventions: DEVICE: Hi-Lo Evac tube (Mallinckrodt Inc, USA) (Instilled blue dye)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Virtual Hospital - a Clinical Trial
Status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease|Telemedicine
Interventions: OTHER: Telemedical admission and treatment in the patients´ own homes instead of conventional admission and treatment at the hospital
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Motexafin Gadolinium Plus Radiation Therapy to the Brain in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: motexafin gadolinium|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Prevalence of SARS-CoV-2 in Conjunctival Swab Samples Among Patients With Conjunctivitis During the COVID-19 Pandemic
Status: COMPLETED
Conditions: Conjunctivitis|SARS-CoV-2|COVID-19|Ocular Infection, Viral|Ocular Inflammation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Staying Well: A Clinical Trial of Mindfulness-Based Stress Reduction and Education Groups for HIV
Status: COMPLETED
Conditions: HIV
Interventions: BEHAVIORAL: Mindfulness-Based Stress Reduction (MBSR)|BEHAVIORAL: HIV-education and self-management workshop
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: N-of-1 Trials for Blood Pressure Medications in Adults
Status: COMPLETED
Conditions: Hypertension|High Blood Pressure
Interventions: DRUG: Losartan|DRUG: Amlodipine|DRUG: Hydrochlorothiazide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on Medical Records of Women Using an Intrauterine Device (IUD) to Analyze the Risks That the IUD Will be Expelled or Perforates the Womb in Relation to Breastfeeding, the Point in Time When the IUD Was Inserted After Childbirth and in Relation to Different Types of IUDs
Status: COMPLETED
Conditions: Intrauterine Devices
Interventions: DEVICE: Intrauterine device
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Feasibility and Effectiveness of Lymphedema Education Program After Gynecological Cancer Surgery
Status: NOT_YET_RECRUITING
Conditions: Lower Extremity Lymphedema
Interventions: BEHAVIORAL: lymphedema education program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage
Status: COMPLETED
Conditions: Aneurysmal Subarachnoid Hemorrhage|Hydrocephalus
Interventions: PROCEDURE: Control intervention|PROCEDURE: Experimental intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace)
Status: UNKNOWN
Conditions: is to Identify Biomarkers That Could Predict the Efficacy of an Adjuvant Letrozol Treatment in Postmenopausal Breast Cancer Patients.
Interventions: DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Low Cost Interventions to Improve Adherence to Childhood Immunization Schedule
Status: COMPLETED
Conditions: Childhood Immunization Completion|Childhood Immunization Dropout|Immunization Card|Center Based Education
Interventions: OTHER: Redesigned immunization card|OTHER: Center based education to mothers/caregivers|OTHER: Redesigned immunization card with center based education to mother/caregivers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19
Status: COMPLETED
Conditions: CoVID-19
Interventions: DRUG: HCQ|OTHER: Standard therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Implementation of a Diagnostic Decision-aid for People With Memory Complaints and Their General Practitioners
Status: COMPLETED
Conditions: Dementia|Dementia Alzheimers|Dementia, Mild
Interventions: OTHER: Diagnostic decision aid s-decided
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of ICCMS in Reducing the Incidence of Dental Caries in Children
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: ICCMS|OTHER: SESC standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Low-contrast Dose Liver CT Using Lean Body Weight Low Monoenergetic Images and Deep Learning-based Reconstruction
Status: COMPLETED
Conditions: Carcinoma, Hepatocellular|Body Weight
Interventions: OTHER: low dose CT contrast media - lean body weight|OTHER: Standard dose CT contrast media
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining
Status: UNKNOWN
Conditions: Opioids Use
Interventions: DRUG: Methadone; NAC|DRUG: Methadone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Safety of a Trivalent Inactivated Influenza Vaccine,Formulation 2011-2012, in Dialysis Patients
Status: UNKNOWN
Conditions: Influenza
Interventions: DRUG: AdimFlu-S
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalized Real-Time DBS and PD Mechanisms
Status: RECRUITING
Conditions: Parkinson Disease
Interventions: DEVICE: Neurostimulation|DRUG: Carbidopa 25/Levodopa 100Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8
Status: COMPLETED
Conditions: Opioid-Related Disorders|Substance-Related Disorders
Interventions: DRUG: 20% N2O|DRUG: 40% N2O|DRUG: 60% N2O|DRUG: 80% N2O
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Effectiveness of Association Mometasone Furoate 0.1% and Salicylic Acid 5% Compared With Mometasone Furoate
Status: SUSPENDED
Conditions: Plaque Psoriasis
Interventions: DRUG: mometasone furoate + salicylic acid|DRUG: Mometasone furoate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Examining the Ability of Herpes Simplex Virus Type 2 (HSV2) Therapy to Reduce HIV Target Cell Numbers in the Cervix
Status: COMPLETED
Conditions: Herpes Simplex Type Two Infection|HIV Infections
Interventions: DRUG: Valacyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Electroporation and Immunotherapy in Metastatic Colorectal Cancer
Status: TERMINATED
Conditions: Metastatic Colorectal Cancer
Interventions: DEVICE: Irreversible electroporation|DEVICE: Calcium electroporation|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Determine the Immunogenicity and Oral Tolerance to Keyhole Limpet Hemocyanin (KLH)
Status: TERMINATED
Conditions: Autoimmune Disorders
Interventions: BIOLOGICAL: Immucothel Alone (Part A)|BIOLOGICAL: Immucothel+Montanide (Part A)|BIOLOGICAL: Immucothel Alone or Immucothel+Montanide (Part B)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study
Status: COMPLETED
Conditions: Recurrent Upper-Respiratory Tract Infections
Interventions: DRUG: J022X ST|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Feasibility and Safety of CareMin650 in Patients at Risk of or Suffering From Oral Mucositis and/or Radiation Dermatitis
Status: COMPLETED
Conditions: Oral Mucositis Due to Radiation|Radiation Dermatitis
Interventions: DEVICE: Photobiomodulation using CareMin650 at 6 Joules (curative intent)|DEVICE: Photobiomodulation using CareMin650 at 3 Joules (prophylactic intent)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Selective Retina Therapy With Real-Time Feedback-Controlled Dosimetry for Treating Acute Idiopathic Central Serous Chorioretinopathy in Korean Patients
Status: COMPLETED
Conditions: Central Serous Chorioretinopathy
Interventions: DEVICE: Selective retina therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Posterior Cruciate Retaining (PCR) Versus Posterior Cruciate Substituting (PCS) Total Knee Arthroplasty (TKA)
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Knee Arthroplasty, Total
Interventions: DEVICE: SCORPIO™
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoantigen Peptide Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy
Status: TERMINATED
Conditions: Pancreas Cancer|Pancreatic Cancer|Cancer of the Pancreas
Interventions: BIOLOGICAL: Neoantigen Peptide Vaccine|DRUG: Poly ICLC|PROCEDURE: Blood for immune monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Access to the Treatment of Anxiety and Depression Among Young Adults
Status: COMPLETED
Conditions: Generalized Anxiety Disorder|Major Depressive Disorder|Social Anxiety Disorder|Panic Disorder|Agoraphobia
Interventions: BEHAVIORAL: Mood Mechanic Course
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Tofacitinib in the Treatment of NSAID Refractory Axial Spondyloarthritis:A Clinical Trial
Status: UNKNOWN
Conditions: Axial Spondyloarthritis
Interventions: DRUG: Tofacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Intrathecal Versus Epidural Fentanyl on Fetal Bradycardia in Labor Combined Spinal Epidural Analgesia
Status: UNKNOWN
Conditions: Labor Pain|Obstetric Pain
Interventions: DRUG: Spinal fentanyl|DRUG: Spinal bupivacaine|DRUG: Spinal Fentanyl and Bupivacaine|DRUG: Epidural fentanyl /spinal bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Tenofovir/Emtricitabine for PMTCT in Africa and Asia (ANRS 12109 TEmAA)
Status: COMPLETED
Conditions: HIV Infection|Pregnancy
Interventions: DRUG: Tenofovir (TDF)|DRUG: Emtricitabine (FTC)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes
Status: COMPLETED
Conditions: Cervical Adenocarcinoma|Cervical Adenosquamous Carcinoma|Cervical Small Cell Carcinoma|Cervical Squamous Cell Carcinoma, Not Otherwise Specified|Stage IB Cervical Cancer|Stage IIA Cervical Cancer|Stage IIB Cervical Cancer|Stage III Cervical Cancer|Stage IVA Cervical Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|PROCEDURE: Lymphadenectomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid Cancer
Status: RECRUITING
Conditions: Metastatic Thyroid Cancer
Interventions: DRUG: Cyclophosphamide|DRUG: Sirolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Allergen Challenge Chamber Study With Single Dose Intranasal GSK1004723 Compared With Placebo
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: GSK1004723 (200mg)|OTHER: Placebo|DRUG: GSK1004723 (1000mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Ropinirole Hydrochloride CR 2mg Tablets of Lupin Limited, India, With REQUIP XL of GlaxoSmithKline Research Triangle Park, in Healthy, Adult, Male, Subjects Under Fed Conditions
Status: COMPLETED
Conditions: Pharmacokinetic Study
Interventions: DRUG: Ropinirole hydrochloride CR 2mg Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Program Reinforcement Impacts Self Management (PRISM)
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: BEHAVIORAL: Office Staff Support|BEHAVIORAL: Peer Support|BEHAVIORAL: Usual Care Support|BEHAVIORAL: Educator Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV
Status: COMPLETED
Conditions: HIV-1-infection
Interventions: DRUG: Saline|DRUG: Lefitolimod|DRUG: 3BNC117 and 10-1074
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Standard TDS Irritation Study: Trained Skin Grader vs. Digital Imaging
Status: WITHDRAWN
Conditions: Skin Manifestations
Interventions: DRUG: TDS Lidocaine 5%; generic|DRUG: TDS Lidocaine 5%; RLD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: NatrOVA Photoallergy Study - NatrOVA Creme Rinse in Healthy Volunteers
Status: COMPLETED
Conditions: Head Lice
Interventions: DRUG: NatrOVA Creme Rinse - 1%|DRUG: NatrOVA Creme Rinse Vehicle Only|DRUG: Blank Patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improved Estimation of GFR by Cystatin C in Preventing Contrast Induced Nephropathy by NAC or Zn
Status: TERMINATED
Conditions: Chronic Kidney Failure
Interventions: DRUG: Acetylcysteine|DRUG: Zinc
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: Long-term Assessment of Balloon Eustachian Tuboplasty for Obstructive Eustachian Tube Disease
Status: NOT_YET_RECRUITING
Conditions: Eustachian Tube Dysfunction
Interventions: DEVICE: Balloon Eustachian Tuboplasty (BET) under general anesthesia.|DEVICE: Insertion of catheter for probing and flushing the Eustachian tube under general anesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Gut-brain Axis: a Novel Target for Treating Behavioral Alterations in Obesity
Status: COMPLETED
Conditions: Neural Response in Caudate|Weight Loss Trial|Impulsivity
Interventions: DIETARY_SUPPLEMENT: PhosphoLean|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Food Challenge With Barley Starch as Active Comparator
Status: SUSPENDED
Conditions: Allergy;Food|Allergy Wheat
Interventions: OTHER: Barley starch|OTHER: Maize starch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Trial Using ANAKINRA, TOCILIZUMAB Alone or in Association With RUXOLITINIB in Severe Stage 2b and 3 of COVID19-associated Disease
Status: UNKNOWN
Conditions: Covid19
Interventions: DRUG: Anakinra +/- Ruxolitinib (stages 2b/3)|DRUG: Anakinra and Ruxolitinib (Advanced stage 3)|DRUG: Tocilizumab +/- ruxolitinib (stages 2b/3)|DRUG: Tocilizumab and Ruxolitinib (Advanced stage 3)|OTHER: Standard of care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: DeVilbiss AutoAdjust With SmartFlex Comparative Study
Status: COMPLETED
Conditions: Obstructive Sleep Apnea
Interventions: DEVICE: SmartFlex|DEVICE: Standard
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Werewolf Flow 50 During ACL Reconstruction
Status: RECRUITING
Conditions: Anterior Cruciate Ligament Injuries|Anterior Cruciate Ligament Rupture|Anterior Cruciate Ligament Tear|Arthrofibrosis of Knee
Interventions: DEVICE: Werewolf FLOW 50|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Acute Nerve Stimulation For Enhancing Human and Cognitive Performance
Status: COMPLETED
Conditions: Concussion, Mild|Autonomic Nervous System|Cognitive
Interventions: DEVICE: Experimental group with 100% intensity setting on Apollo Neuro device|DEVICE: Active Comparator group with 10% intensity setting on the Apollo Neuro device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Acupuncture Plus Fire Needle and Acupuncture on Lateral Epicondylitis
Status: COMPLETED
Conditions: Lateral Epicondylitis|Tennis Elbow|Acupuncture
Interventions: PROCEDURE: acupuncture plus fire needle therapy|PROCEDURE: acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Status: COMPLETED
Conditions: Brain Injury Traumatic Severe (Diagnosis)|Coma|Consciousness, Level Altered|Anoxic Brain Injury
Interventions: DRUG: Methylphenidate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study of LX-039 Tablets
Status: COMPLETED
Conditions: Advanced Breast Cancer
Interventions: DRUG: LX-039 tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of Photodamage
Status: COMPLETED
Conditions: Photoaging
Interventions: DRUG: adapalene gel, 0.3%|DRUG: tretinoin 0.05% emollient cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Immune Response Post Pry Vaccination of 2 Formulations of DTPw-HBV Vaccine Given With Rotavirus Vaccine to Infants
Status: COMPLETED
Conditions: Hepatitis B
Interventions: BIOLOGICAL: Tritanrix™-HepB|BIOLOGICAL: Rotarix™|BIOLOGICAL: Zilbrix™|BIOLOGICAL: Triple Antigen™|BIOLOGICAL: Engerix™-B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Analysis of the Patients With Cavitary Pulmonary TB and Endobronchial TB in the PPM-UUH Cohort
Status: COMPLETED
Conditions: Tuberculosis|Tuberculosis, Pulmonary|Cavity|Bronchoscopy|Acid Fast Bacilli Infection|Multi-drug Resistant Tuberculosis|Transmission|Insolation
Interventions: OTHER: Observation of AFB smear/culture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dexamethasone in Controlling Dyspnea in Patients With Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Dyspnea|Malignant Neoplasm
Interventions: DRUG: Dexamethasone|OTHER: Placebo|OTHER: Questionnaire Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Intravenous Cardioversion of Atrial Fibrillation (AF) With AZD1305
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: AZD1305|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Time Efficiency of Intracorporeal Orthotopic Diversion With Robotic Staplers After Robot Assisted Radical Cystectomy
Status: COMPLETED
Conditions: Cystectomy|Robotic Surgical Procedures|Surgical Staplers
Interventions: PROCEDURE: Intracorporeal stapled neobladder using robotic staplers
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Esomeprazole to Aerosolized, Swallowed Fluticasone for Eosinophilic Esophagitis
Status: COMPLETED
Conditions: Esophagitis
Interventions: DRUG: esomeprazole|DRUG: fluticasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: One Staged Hybrid Approach of Surgical/Catheter Ablation for Persistent Atrial Fibrillation
Status: UNKNOWN
Conditions: Persistent Atrial Fibrillation
Interventions: PROCEDURE: Radiofrequency ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of the Effects of Two Different Treatment Programs on Chronic Low Back Pain
Status: COMPLETED
Conditions: Chronic Low-back Pain
Interventions: OTHER: conventional physiotherapy|OTHER: conventional physiotherapy plus kinesiotaping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Insulin Aspart Produced by the NN2000 Process to the Current Process in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Efficacy and Safety of SHR1459 Tablets in Patients With Primary Membranous Nephropathy
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Membranous Nephropathy
Interventions: DRUG: SHR1459 Low Dose|DRUG: SHR1459 High Dose|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass
Status: ACTIVE_NOT_RECRUITING
Conditions: Obesity, Morbid
Interventions: PROCEDURE: SADI-S|PROCEDURE: RYGB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Leukapheresis Study for Immune Responses in Healthy US Adults Who Receive BCG Vaccination Followed by Boosting With AERAS-402
Status: COMPLETED
Conditions: Tuberculosis
Interventions: BIOLOGICAL: AERAS-402|BIOLOGICAL: Placebo|BIOLOGICAL: BCG (1-8 x105 cfu ID)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of SI-B003 and BL-B01D1+SI-B003 in Patients With Locally Advanced or Metastatic Urothelial Carcinoma and Other Solid Tumors
Status: RECRUITING
Conditions: Urothelial Carcinoma|Solid Tumor
Interventions: DRUG: BL-B01D1|DRUG: SI-B003
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of the Breathing Muscular Training of Institutionalized Elderly
Status: COMPLETED
Conditions: In Brazil, Which Has an Increasing Number of Elderly People.|The Physiological Alterations of Aging Are Systemic.
Interventions: OTHER: Comparison of different breathing muscular training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Examining Feasibility, Acceptability, and Sustainability of a Novel Personalized Smartphone Intervention for Suicide - Randomized Trial
Status: RECRUITING
Conditions: Suicide and Self-harm|Suicide|Suicide, Attempted|Suicidal Ideation
Interventions: BEHAVIORAL: Mobile Application to Prevent Suicide (MAPS)|BEHAVIORAL: EMA Monitoring Only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cap-assisted Endoscopic Sclerotherapy for Internal Hemorrhoids and Rectal Prolapse
Status: RECRUITING
Conditions: Internal Hemorrhoid|Rectal Prolapse
Interventions: PROCEDURE: Cap-assisted endoscopic sclerotherapy using long needle|PROCEDURE: Cap-assisted endoscopic sclerotherapy using short needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Leukemia, Lymphocytic|Lymphoblastic Lymphoma|T-cell Lymphoma|T-cell Leukemia|Recurrent Disease|Acute Leukemia
Interventions: DRUG: Palbociclib|DRUG: Cytarabine|DRUG: Methotrexate|DRUG: Hydrocortisone|DRUG: Doxorubicin|DRUG: Prednisolone|DRUG: Vincristine|DRUG: Pegaspargase|DRUG: Hydrocortisone|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combining Attention and Metacognitive Training to Improve Goal Directed Behavior in Veterans With TBI
Status: COMPLETED
Conditions: Mild Traumatic Brain Injury
Interventions: BEHAVIORAL: Goal Management Training|BEHAVIORAL: Attention Training|BEHAVIORAL: Brain Health Workshop|BEHAVIORAL: National geographic movies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-348(3)
Status: COMPLETED
Conditions: Hypertension and Dyslipidemia
Interventions: DRUG: CKD-348(3)|DRUG: CKD-828, D097, D337
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: AqueSys Microfistula Implant in Refractory Glaucoma
Status: COMPLETED
Conditions: Glaucoma|Glaucoma, Open-Angle
Interventions: DEVICE: AqueSys Microfistula Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Cetuximab and NK Immunotherapy for Recurrent Non-small Cell Lung Cancer
Status: COMPLETED
Conditions: Recurrent Non-small Cell Lung Cancer
Interventions: DRUG: Cetuximab|BIOLOGICAL: NK immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diabetes Journey: An Adolescent Adherence Barriers Intervention
Status: COMPLETED
Conditions: Type 1 Diabetes|Adherence, Patient
Interventions: BEHAVIORAL: Diabetes Journey|BEHAVIORAL: Enhanced Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Lifestyle Intervention in Preparation for Pregnancy (LIPP)
Status: COMPLETED
Conditions: Obesity|Lifestyle-related Condition|Macrosomia, Fetal
Interventions: BEHAVIORAL: Lifestyle Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: New Treatment Modalities for Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: PROCEDURE: Active Surveillance|PROCEDURE: Robot-Assisted Radical Prostatectomy|RADIATION: Intensity-Modulated Radiotherapy|RADIATION: Real-time brachytherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PRT1419 as Monotherapy or in Combination With Azacitidine or Venetoclax in R/R Myeloid or B-cell Malignancies
Status: TERMINATED
Conditions: Acute Myeloid Leukemia|B-cell Non-Hodgkin Lymphoma|Chronic Lymphocytic Leukemia|Chronic Myelomonocytic Leukemia|Follicular Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Myelodysplastic Syndromes|Myeloproliferative Neoplasm|Small Lymphocytic Lymphoma
Interventions: DRUG: PRT1419|DRUG: Azacitidine|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: T-DM1 Combined With CDK4/6 Inhibitor Ribociclib
Status: ENROLLING_BY_INVITATION
Conditions: HER2-positive Advanced Breast Cancer
Interventions: DRUG: Ribociclib Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Computer-Assisted Total Knee Replacement Kinematics: DePuy Sigma Posterior Cruciate Substituting Knee and the DePuy Sigma RP Rotating Platform Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DEVICE: DePuy P.F.C.® Sigma Rotating Platform Knee
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aspirin on HIV Disease Progression Among HIV- Infected Individuals Initiating Anti- Retroviral Therapy
Status: SUSPENDED
Conditions: Hiv|Cardiovascular Diseases
Interventions: DRUG: aspirin enteric coated tablet 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Autologous T Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL) Patients
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: PROCEDURE: Infusion of Activated & Expanded Autologous T Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Deferasirox on Non-Alcoholic-Steatohepatitis
Status: COMPLETED
Conditions: Non-alcoholic Steatohepatitis|Increased Iron Storage / Disturbed Distribution
Interventions: DRUG: Exjade
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comapring Luteal Phase Support in IVF Patients Who Are at High Risk for Developing OHSS
Status: UNKNOWN
Conditions: Infertility
Interventions: DRUG: Decapeptyl|DRUG: hCG luteal support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Multifaceted Comparison of Ultrasound-guided Ablation and Laparoscopic Adrenalectomy for Aldosterone-producing Adenoma
Status: RECRUITING
Conditions: Aldosterone-producing Adenoma|Radiofrequency Ablation
Interventions: PROCEDURE: radiofrequency ablation|PROCEDURE: laparoscopic adrenalectomy|DRUG: Hypotensive Drugs
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Evaluate the Efficacy of TIRZEPATIDE for the Treatment of Moderate to Severe HS Hidradenitis Suppurativa
Status: NOT_YET_RECRUITING
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: TIRZEPATIDE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Associations Between General Movements Assessments and Cognitive Development
Status: COMPLETED
Conditions: Cerebral Palsy|Infant Development|Cognitive Dysfunction|Cognitive Developmental Delay|Cognitive Impairment, Mild|Infant, Small for Gestational Age|Infant, Premature, Diseases|Infant Asphyxia|Infant, Very Low Birth Weight
Interventions: OTHER: measurements
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Online Cognitive Control Training for Remitted Depressed Patients
Status: COMPLETED
Conditions: Major Depression in Remission
Interventions: BEHAVIORAL: Cognitive control training|BEHAVIORAL: Active control training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intra-sheath vs Extra-sheath Injection for De Quervain's Tenosynovitis
Status: RECRUITING
Conditions: De Quervain Tenosynovitis
Interventions: PROCEDURE: Intra-sheath injection|PROCEDURE: Extra-sheath injection|DEVICE: Ultrasound
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Rectal Cancer: Local Staging, Re-staging and Assessment of Lymph Nodes Using Pet-Ct, CT-Perfusion and 3T MRI
Status: COMPLETED
Conditions: Rectal Cancer
Interventions: RADIATION: ct and mri scans|RADIATION: ct, mri and pet scan|RADIATION: ct, mri and pet scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of D-cycloserine on a Short Imagery Rescripting Intervention for Subclinical PTSD
Status: WITHDRAWN
Conditions: PTSD
Interventions: BEHAVIORAL: CBT + ImRs|BEHAVIORAL: CBT + I.E.|DRUG: D-Cycloserine|DRUG: Placebo|DRUG: Study Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Integrating CAMH Into PHC and Traditional Healers' Practice in Uganda: a Randomized Controlled Trial
Status: COMPLETED
Conditions: Community Mental Health Services
Interventions: OTHER: CAMH training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Beta-Blockers in Heart Failure: Pharmacy-level Intervention Comparison
Status: COMPLETED
Conditions: Heart Failure
Interventions: OTHER: Level 1: (provide site-specifi information)|OTHER: Level 2 (Provide site- and patient-specific information)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Extension Study of ABP-671 in Participants With Gout
Status: ENROLLING_BY_INVITATION
Conditions: Gout
Interventions: DRUG: ABP-671|DRUG: Allopurinol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Evaluation of Reverse End to Side Anterior Interosseous Nerve to Ulnar Nerve Transfer for Severe Compressive Ulnar Neuropathy at the Elbow
Status: COMPLETED
Conditions: Severe Compressive Ulnar Nerve Neuropathy (McGowan Grade III)
Interventions: PROCEDURE: Surgery:ulnar nerve transposition with AIN to ulnar nerve transfer|PROCEDURE: Surgery:ulnar nerve subcutaneous transposition without AIN to ulnar nerve transfer.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials
Status: UNKNOWN
Conditions: Endocarditis
Interventions: DRUG: 99mTc-Leukoscan® scintigraphy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Nerve Transfers in Post-stroke Spasticity
Status: ENROLLING_BY_INVITATION
Conditions: Spasticity as Sequela of Stroke|Nerve Transfers
Interventions: PROCEDURE: Cognitive nerve transfers to spastic upper extremity muscles in stroke patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT