pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: THE EFFECT OF CYP3A5 GENOTYPE ON THE PHARMACOKINETICS OF MARAVIROC
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Maraviroc (Part 1)|DRUG: Maraviroc (Part 2)|DRUG: Darunavir/cobicistat (Part 2)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Status: TERMINATED
Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: DRUG: Placebo ELLIPTA|DRUG: Nemiralisib ELLIPTA 50 µg|DRUG: Nemiralisib ELLIPTA 100 µg|DRUG: Nemiralisib ELLIPTA 250 µg|DRUG: Nemiralisib ELLIPTA 500 µg|DRUG: Nemiralisib ELLIPTA 750 µg|DRUG: Albuterol (Salbutamol) MDI or nebules|DRUG: Standard of care therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of An Anti-CD38 Antibody Drug Conjugate in Relapsed or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: STI-6129
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|ARDS|Respiratory Distress Syndrome, Acute|Respiratory Insufficiency|Respiratory Distress Syndrome|Shock Lung|Severe Acute Respiratory Syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study for Disease Profiling of Asthma and Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Asthma|Pulmonary Disease, Chronic Obstructive
Interventions: OTHER: Medical tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Investigate the Safety and Efficacy of K-321 in Patients With Fuchs Endothelial Corneal Dystrophy (FECD) Following Descemetorhexis
Status: COMPLETED
Conditions: Fuchs' Endothelial Corneal Dystrophy
Interventions: DRUG: K-321 Solution|DRUG: Placebo Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment
Status: COMPLETED
Conditions: Symptomatic Irreversible Pulpitis
Interventions: DRUG: Aceclofenac|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: An Observational Study of Follitropin Alpha Biosimilar: the Real-world Data
Status: COMPLETED
Conditions: Reproductive Issues|Reproductive Disorder|Fertility Disorders|Fertility Issues|Gynecologic Disease|IVF
Interventions: DRUG: Follitropin Alfa|DRUG: Follicle Stimulating Hormone/Luteinizing Hormone|DRUG: Follitropin Alfa|DRUG: Follitropin Alfa|DRUG: Follicle Stimulating Hormone/Luteinizing Hormone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of the Medullary Microenvironment in Acute Childhood Leukemia
Status: RECRUITING
Conditions: Acute Lymphoid Leukemia|Acute Myeloid Leukemia in Children
Interventions: PROCEDURE: Biological sampling in patients|PROCEDURE: Biological sampling in control patients
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Pharmacokinetic and Safety Study of Nab®-Paclitaxel (ABI-007) Plus Gemcitabine in Subjects With Advanced Pancreatic Cancer Who Have Cholestatic Hyperbilirubinemia
Status: TERMINATED
Conditions: Pancreatic Neoplasms|Cholestasis
Interventions: DRUG: nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sorafenib as Adjuvant to Radioiodine Therapy in Non-Medullary Thyroid Carcinoma
Status: COMPLETED
Conditions: Thyroid Cancer
Interventions: DRUG: Sorafenib (nexavar)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Fissure Sealant and Topical Fluoride Application in Preventing Dental Caries
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: placement of fissure sealant|OTHER: fluoride varnish|OTHER: silver fluoride|OTHER: placebo control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Open Tray Versus Digital Impressions on the Passivity and Prosthetic Complications of Full Arch Screw-retained Prosthesis
Status: UNKNOWN
Conditions: Passivity|Prosthetic Complications
Interventions: DEVICE: Digital impression technique|OTHER: Open tray impression technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intervention to Improve Caregiver Palliative Care Knowledge and Attitudes
Status: COMPLETED
Conditions: Cancer
Interventions: BEHAVIORAL: Psychoeducational Video on Palliative Care|BEHAVIORAL: Educational Video on Nutrition
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Switched Memory B-cells as a Marker for Humoral Immune System Recovery in Patients With Secondary Antibody Deficiency Due to Hematological Malignancies
Status: NOT_YET_RECRUITING
Conditions: Secondary Antibody Deficiency
Interventions: DRUG: Immunoglobulin replacement therapy (IGRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Stepwise Approach To sUbstrate Modification for Ventricular Tachycardia
Status: TERMINATED
Conditions: Ventricular Tachycardia|Catheter Ablation|Tachycardia, Ventricular
Interventions: PROCEDURE: catheter-based ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Feasibility of Hyperkalemic Cardioplegia With Diazoxide in Cardiac Surgery (CPG-DZX) Trial
Status: RECRUITING
Conditions: Myocardial Stunning
Interventions: DRUG: IV Diazoxide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study Evaluating the Efficacy of Loco-regional Anaesthesia PECS on Chronic Pain of a Mastectomy
Status: COMPLETED
Conditions: Breastcancer|Mastectomy
Interventions: PROCEDURE: Loco-regional anaesthesia
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, and Efficacy of 21 Days Dermal Application of MRX-6 on Mild to Moderate Contact Dermatitis
Status: COMPLETED
Conditions: Allergic Contact Dermatitis
Interventions: DRUG: MRX-6|DRUG: Steroid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Randomized Controlled Trial of Inferior Vena Cava Ultrasound-guided Fluid Management in Septic Shock Resuscitation
Status: COMPLETED
Conditions: Septic Shock
Interventions: PROCEDURE: IVC Ultrasound-guided|DRUG: Antibiotics|DRUG: Vasopressor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Relaxing Music on Blood Pressure and Resting Heart Rate
Status: COMPLETED
Conditions: Prehypertension|Blood Pressure|Resting Heart Rate
Interventions: OTHER: Passive Music Therapy|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Decitabine Combining Modified CAG Followed by HLA Haploidentical Peripheral Blood Mononuclear Cells Infusion for Elderly Patients With Acute Myeloid Leukemia(AML）
Status: COMPLETED
Conditions: MDS|AML
Interventions: DRUG: Decitabine|DRUG: Cytarabine|DRUG: aclacinomycin|DRUG: Granulocyte colony-stimulating factor|OTHER: HLA haploidentical mononuclear cells infusion
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Centrum® Silver® in Improving Micronutrient Status in Older Men
Status: UNKNOWN
Conditions: Vitamin Deficiency|Mineral Deficiency|Aging
Interventions: DIETARY_SUPPLEMENT: Centrum Silver Mens' Formula|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison of Buprenorphine to Morphine in Treatment of Neonatal Abstinence Syndrome (NAS)
Status: COMPLETED
Conditions: Neonatal Abstinence Syndrome|Neonatal Withdrawal Syndrome
Interventions: DRUG: Buprenorphine|DRUG: Morphine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Patient Satisfaction and Biting Force of New Design of Extracoronal Attachment (O T Cap Unilateral Attachment) Versus Conventional Partial Denture for Treatment of Unilateral Mandibular Distal Extension Area
Status: UNKNOWN
Conditions: Patient Acceptance of Health Care
Interventions: OTHER: O T unilateral attachment|OTHER: New design of extracoronal attachment system
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Phase I Study of Combination of Gedatolisib With Palbociclib and Faslodex in Patients With ER+/HER2- Breast Cancer
Status: UNKNOWN
Conditions: Breast Cancer
Interventions: DRUG: Gedatolisib|DRUG: Faslodex|DRUG: Palbociclib|DRUG: Zoladex
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of ZL-1102 in Patients With Chronic Plaque Psoriasis
Status: RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: ZL-1102 1% w/w gel BID for 16 weeks|DRUG: ZL-1102 3% w/w gel BID for 16 weeks|DRUG: ZL-1102 3% w/w gel QD for 16 weeks|DRUG: Placebo ZL-1102 0% w/w gel BID for 16 weeks|DRUG: Placebo ZL-1102 0% w/w gel QD for 16 weeks
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Innovative Care Pathway in Physical Activity and Behavior Change in Coronary Patients Post-cardiac Rehabilitation
Status: NOT_YET_RECRUITING
Conditions: Individualised Physical Activity Program|Coronary Patient
Interventions: OTHER: Individuals activity programs|OTHER: activity program|OTHER: no Physical Activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Gefitinib in Treating Patients With Malignant Mesothelioma
Status: COMPLETED
Conditions: Advanced Malignant Mesothelioma|Epithelial Mesothelioma|Recurrent Malignant Mesothelioma|Sarcomatous Mesothelioma
Interventions: DRUG: gefitinib|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Peer Groups for Healthy Pregnancy & HIV Prevention for Young Malawian Women
Status: COMPLETED
Conditions: HIV|Pregnancy|Sexually Transmitted Infections
Interventions: BEHAVIORAL: Mzanga Samala Moyo Wako ([Mzanga] Peer Groups
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Can Remote Photoplethysmography Be Used for Contactless Vital Sign Acquisition in a Healthcare Setting? A Prospective Comparative Study.
Status: UNKNOWN
Conditions: Coronavirus|Cardiac Disease|Respiratory Disease|Vascular Diseases
Interventions: DEVICE: Remote Photoplethysmography (rPPG) vital sign acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: PREVENT: PeRomEter Visualization to ENd Treatment-related Lymphedema
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphedema
Interventions: OTHER: Cohort I (patients receiving annual lymphedema screening|OTHER: Cohort II (patients followed intensively for lymphedema)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Innate Immune Response During Community Acquired Pneumonia
Status: RECRUITING
Conditions: Community-acquired Pneumonia|Acute Respiratory Distress Syndrome|Innate Immunity
Interventions: OTHER: Blood samples|OTHER: Tracheal Aspirates|OTHER: Surplus of Broncho-alveolar lavage fluid
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: DRUG: Chloroquine Phosphate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas
Status: COMPLETED
Conditions: Glioblastoma Multiforme|Gliosarcoma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Anaplastic Mixed Oligoastrocytoma
Interventions: DRUG: ZD6474 (Vandetanib)|DRUG: Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Methimazole in Patients With Progressive Glioblastoma
Status: RECRUITING
Conditions: Glioblastoma|Glioma
Interventions: DRUG: Methimazole|PROCEDURE: Recurrent Glioblastoma Surgical Resection|DIAGNOSTIC_TEST: Pharmacodynamic Assays
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia
Status: UNKNOWN
Conditions: Leukemia
Interventions: DRUG: asparaginase|DRUG: cyclophosphamide|DRUG: cytarabine|DRUG: daunorubicin hydrochloride|DRUG: dexamethasone|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: ifosfamide|DRUG: leucovorin calcium|DRUG: mercaptopurine|DRUG: methotrexate|DRUG: prednisone|DRUG: thioguanine|DRUG: vincristine sulfate|DRUG: vindesine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Single Dose Study to Assess the Pharmacokinetics of SCH 900800 in Subjects With Parkinson's Disease Being Treated With Levodopa (L-DOPA) (P08235)
Status: WITHDRAWN
Conditions: Parkinson's Disease
Interventions: DRUG: SCH 900800
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma.
Status: NOT_YET_RECRUITING
Conditions: Oral Squamous Cell Carcinoma
Interventions: DRUG: Three-Week Treatment Regimen with Trastuzumab in Combination with Docetaxel and Platinum Triple Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Combination of IntraCoronary Bolus Abciximab and Aspiration Thrombectomy in STEMI
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Gp 2b 3a inhibitor|DEVICE: aspiration thrombectomy|OTHER: Both use
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Handling Experience With the BI 695501 Autoinjector in Patients With Rheumatoid Arthritis Followed by an Extension Phase Using BI 695501 Prefilled Syringe
Status: COMPLETED
Conditions: Arthritis, Rheumatoid
Interventions: DRUG: BI 695501 Autoinjector|DRUG: BI 695501 Prefilled syringe
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Measurement of Retinal Blood Flow, Retinal Oxygenation and Retinal Oxygen Extraction in Healthy Subjects During Normoxia and Systemic Hyperoxia
Status: COMPLETED
Conditions: Healthy|Normoxia|Systemic Hypoxia
Interventions: DRUG: Oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Characterizing Breast Cancer With 68Ga-FAPI PET/CT (PFB-01)
Status: ACTIVE_NOT_RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: 68Ga-FAPI PET/CT scan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacokinetic Study to Evaluate the Bioequivalence of a Test Formulation Compared to an Equivalent Dose of a Reference Drug Product
Status: UNKNOWN
Conditions: Healthy Adult Subjects
Interventions: DRUG: Nexium powder for injection and infusion 40 mg|DRUG: Esomelone Powder for Solution for Injection / Infusion 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: Light Therapy for the Treatment of Back Pain in Pilots (LLL&Pilots)
Status: UNKNOWN
Conditions: Back Pain
Interventions: DEVICE: GaAlAs 808nm laser|DEVICE: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Twin Block, Pain Medications and Third Molar Extractions
Status: NOT_YET_RECRUITING
Conditions: Acute Pain
Interventions: DRUG: Twin block local anesthetic nerve block using standard dental anesthetic|OTHER: Twin block with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Anesthetic Efficacy of Lidocaine and Articaine as Buccal Injection for Maxillary Premolar Teeth Extraction.
Status: ACTIVE_NOT_RECRUITING
Conditions: Anesthesia, Local
Interventions: PROCEDURE: Maxillary extraction without palatal injection|PROCEDURE: Maxillary extraction with buccal and palatal injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Sentinel NOSE Study: Prospective Registration Study on the Sentinel Node Procedure for Bulky Squamous Cell Carcinoma of the Nasal Vestibule.
Status: RECRUITING
Conditions: Squamous Cell Carcinoma of the Nasal Vestibule
Interventions: PROCEDURE: Sentinel node procedure
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Thoracic And Lumbar Burst Fracture: Correlation Between Structural Changes And Clinical Outcome Of Treatment
Status: COMPLETED
Conditions: Traumatic Burst Fractures of the Thoracic or Lumbar Spine.|Normal Neurological Function
Interventions: PROCEDURE: Arthrodesis|DEVICE: Brace
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sciatic Nerve Block, Adductor Canal Block, or IPACK Block
Status: RECRUITING
Conditions: Post Operative Pain
Interventions: PROCEDURE: IPACK block|PROCEDURE: adductor canal block|PROCEDURE: sciatic nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Prone Position in Non-Invasive Ventilation and High-Flow Oxygen Therapy
Status: UNKNOWN
Conditions: Evaluation of Prone Position Effect During NIV and HFNC on Acute Hypoxemic Respiratory Failure
Interventions: DEVICE: Prone position during non-invasive respiratory support
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Randomized, Open-Label, Single-Dose, Small Study to Evaluate the Safety and Effectiveness of Hydromorphone in Patients With Short Term, Moderate to Severe Postoperative Pain
Status: COMPLETED
Conditions: Pain, Postoperative|Orthopedic Procedures|Analgesia
Interventions: DRUG: OROS hydromorphone HCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Time-motion Study Comparing Self- to Nurse-vaccination With Influenza Vaccine
Status: COMPLETED
Conditions: Influenza|Vaccination Site Reactions (HT)
Interventions: BIOLOGICAL: Intanza|BIOLOGICAL: Vaxigrip
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Preventing Cardiac Complication of COVID-19 Disease With Early Acute Coronary Syndrome Therapy: A Randomised Controlled Trial.
Status: TERMINATED
Conditions: COVID-19
Interventions: DRUG: Aspirin 75mg|DRUG: Clopidogrel 75mg|DRUG: Rivaroxaban 2.5 MG|DRUG: Atorvastatin 40mg|DRUG: Omeprazole 20mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
Status: RECRUITING
Conditions: Lymphoma
Interventions: DRUG: Ibrutinib|DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Dexamethasone|DRUG: Cisplatin|DRUG: Mesna|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: G-CSF|DRUG: Selinexor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Post Approval Study of the CyPass System
Status: TERMINATED
Conditions: Primary Open-angle Glaucoma|Cataract
Interventions: DEVICE: CyPass Micro-Stent implanted with CyPass 241-S applier|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Immunological Equivalence Between Two Investigational Influenza Vaccines in Adults (H1N1)
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Influenza vaccine GSK2340272A|BIOLOGICAL: Influenza vaccine GSK2340274A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparative Assessment of Adjuvant Effect of Cultured Epidermal Autografts Versus Skin Allografts on Wound Healing of Burns Treated With Widely Expanded Skin Autograft Using Meek Micrografting Technique MEEKADEAU
Status: UNKNOWN
Conditions: Burn Wounds
Interventions: PROCEDURE: cryopreserved skin allografts.|PROCEDURE: Cultured Epidermal Autografts
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Tirzepatide (LY3298176) in Healthy Participants and Participants With Type 2 Diabetes (T2DM)
Status: COMPLETED
Conditions: Healthy|Type 2 Diabetes Mellitus (T2DM)
Interventions: DRUG: Tirzepatide|DRUG: Placebo|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Radiographic Analysis Using PureGen Versus Autologous Bone in Posterolateral Fusion (PLF)
Status: TERMINATED
Conditions: Lumbar Degenerative Disc Disease
Interventions: BIOLOGICAL: PureGen Osteoprogenitor Cell Allograft|PROCEDURE: Autograft bone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimising Rotavirus Vaccine in Aboriginal Children
Status: ACTIVE_NOT_RECRUITING
Conditions: Viral Gastroenteritis Due to Rotavirus
Interventions: DRUG: Rotarix (RV1)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: RGN-259|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effects of Repetitive Transcranial Magnetic Stimulation in Healthy Human Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DEVICE: repetitive transcranial magnetic stimulation (rTMS)|DEVICE: repetitive transcranial magnetic stimulation (rTMS)|DEVICE: sham repetitive transcranial magnetic stimulation (rTMS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: HAIC Combined With Durvalumab and Tremelimumab and Lenvatinib in uHCC
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: HAIC+STRIDE+Len
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multi-center Study to Evaluate the Safety and Efficacy of Aesculap MonoMax® for Abdominal Wall Closure
Status: COMPLETED
Conditions: Primary Median Laparotomy
Interventions: DEVICE: MonoMax®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitrate INFORMER Nitrosamine Study
Status: COMPLETED
Conditions: Health Risk Behaviors
Interventions: DIETARY_SUPPLEMENT: Meat with added nitrate|DIETARY_SUPPLEMENT: Meat with added nitrate plus vegetables
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study
Status: NOT_YET_RECRUITING
Conditions: Alcohol Use Disorder (AUD)|Post Traumatic Stress Disorder (PTSD)
Interventions: DRUG: Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 40µg|DRUG: Dexmedetomidine (DEX) for sublingual (SL) administration (BXCL501) - 80µg
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of a Diaphragmatic Breathing Training Program in Chronic Obstructive Pulmonary Disease (COPD) Patients
Status: COMPLETED
Conditions: COPD
Interventions: OTHER: Diaphragmatic breathing training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Effect of MCS® in Prostate Cancer Prevention
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Placebo|DRUG: MCS®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Fecal Microbiota Transplantation in Clostridioides Difficile Infection First Episode and First Recurrence
Status: RECRUITING
Conditions: Clostridioides Difficile Infection
Interventions: DRUG: oral capsulized Fecal Microbiota Transplantation|DRUG: Vancomycin or Fidaxomicin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buscopan Versus Acetaminophen for Acute Abdominal Pain in Children
Status: COMPLETED
Conditions: Abdomen, Acute|Children
Interventions: DRUG: Acetaminophen, Analgesics, Non-Narcotic|DRUG: Hyoscine butylbromide, Analgesics, Non-Narcotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Two Types of Needle for Oocytes Retrieval
Status: COMPLETED
Conditions: Infertility, Female|ART
Interventions: DEVICE: Oocyte retrieval with only aspiration system "SL1(Cook® Single Lumen)"|DEVICE: Oocyte retrieval with aspiration and flushing system "DL1 (Cook® EchoTip® Double Lumen)"
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Ataluren in Previously Treated Participants With Nonsense Mutation Dystrophinopathy (nmDBMD)
Status: ENROLLING_BY_INVITATION
Conditions: Duchenne Muscular Dystrophy
Interventions: DRUG: Ataluren
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prospective Randomized Trial Comparing DEB Versus Conventional PTA for the Treatment of Hemodialysis AVF or AVG Stenoses
Status: COMPLETED
Conditions: Stenosis of Arteriovenous Dialysis Fistula|Arteriovenous Graft Stenosis
Interventions: DEVICE: Conventional PTA|DEVICE: Drug Eluting Balloon (DEB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Active Surveillance for Adverse Events Following Immunization With the Butantan Trivalent Influenza Vaccine (2018)
Status: COMPLETED
Conditions: Influenza, Human|Orthomyxoviridae Infections|RNA Virus Infections|Respiratory Tract Infections|Virus Diseases|Vaccines|Physiological Effects of Drugs
Interventions: BIOLOGICAL: Seasonal Influenza Vaccine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer|Metastasis
Interventions: DRUG: Abemaciclib|DRUG: Bicalutamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive Paracetamol for Prevention of Intraoperative Shoulder Tip Pain
Status: UNKNOWN
Conditions: Cesarean Section
Interventions: DRUG: paracetamol|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Treating Psychosocial Distress in Glaucoma
Status: NOT_YET_RECRUITING
Conditions: Glaucoma, Primary Open Angle|Distress, Emotional|Anxiety|Depression
Interventions: BEHAVIORAL: Acceptance commitment therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation
Status: COMPLETED
Conditions: COPD|Chronic Bronchitis|Emphysema
Interventions: DEVICE: pneumatic vest|OTHER: placebo pneumatic vest
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Real Dry Needling and Placebo Dry Needling Applied With and Without Ultrasound Guidance on the Infraspinatus Muscle
Status: NOT_YET_RECRUITING
Conditions: Tendinopathy|Rotator Cuff
Interventions: PROCEDURE: Dry needling with and without ultrasound guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety, Efficacy and Pharmacokinetics of ThisCART19A in Patients With Refractory or Relapsed B Cell Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Refractory or Relapsed B Cell Lymphoma
Interventions: DRUG: ThisCART19A|DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: Etoposide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes
Status: COMPLETED
Conditions: Type 1 Diabetes
Interventions: OTHER: 60-minute exercise|DEVICE: Insulin pump|DEVICE: Dexcom G4 Platinum glucose sensor|DRUG: Insulin|OTHER: Single-hormone closed-loop strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Phase I Study of FYU-981
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: FYU-981, (Oral single dosing)|DRUG: Placebo, (Oral single dosing)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice
Status: ACTIVE_NOT_RECRUITING
Conditions: Urothelial Carcinoma|Non-Small Cell Lung Cancer|Small Cell Lung Cancer|Hepatocellular Carcinoma
Interventions: DRUG: Atezolizumab
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Atherosclerosis Monitoring and Atherogenicity Reduction Study
Status: COMPLETED
Conditions: Carotid Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: Allicor|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD)
Status: RECRUITING
Conditions: Major Depressive Disorder
Interventions: DRUG: Zuranolone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Promoting Co-Parenting and Reducing Hazardous Drinking in New Families
Status: RECRUITING
Conditions: Parenting|Parent-Child Relations|Drinking, Alcohol|Adjustment
Interventions: BEHAVIORAL: Healthy Foundations|BEHAVIORAL: Family Foundations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Ulcerative Colitis Relapse Prevention by Prebiotics
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DIETARY_SUPPLEMENT: Synergy-1|DIETARY_SUPPLEMENT: Maltodextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: ALK33BUP-201: Safety and Tolerability Study of ALKS 33-BUP (ALKS 5461) Administration in Subjects With MDD
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: ALKS 5461|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Luteolin for the Treatment of People With Schizophrenia
Status: RECRUITING
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DIETARY_SUPPLEMENT: Luteolin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Survival Thermal Blanket Versus Draping Fabric to Prevent Hypothermia in Geriatric Surgical Patients
Status: COMPLETED
Conditions: Hypothermia; Anesthesia
Interventions: DEVICE: survival thermal blanket|DEVICE: draping fabric
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Fludarabine and Cyclophosphamide + Rituximab
Status: COMPLETED
Conditions: Follicular Lymphoma
Interventions: DRUG: rituximab|DRUG: rituximab,fludarabine, cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane In Acute Myocardial Infarction
Status: COMPLETED
Conditions: Acute Myocardial Infarction
Interventions: DRUG: Oxygen + Sevoflurane|DRUG: Oxygen (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of an Electronic Cognitive Aid Versus Static Cognitive Aid on the Management of a Simulated Crisis
Status: COMPLETED
Conditions: Cognitive Aids
Interventions: OTHER: Electronic Cognitive Aid|OTHER: Static Cognitive Aid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DurAVR™ THV System: First-In-Human Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Symptomatic Aortic Stenosis|Severe Aortic Valve Stenosis|Aortic Valve Calcification
Interventions: DEVICE: DurAVR™ THV System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: Breast Screening & Patient Navigation (BSPAN2): Evaluating a De-Centralized Regional Delivery System for Rural Underserved
Status: COMPLETED
Conditions: Breast Cancer in Situ
Interventions: BEHAVIORAL: BSPAN
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Effectiveness of Premixed Bioactive Bioceramic MTA (Neo-Putty®) in Pulpotomies Primary Teeth
Status: ACTIVE_NOT_RECRUITING
Conditions: Pulpotomies on Primary Molars
Interventions: OTHER: Neo-Putty® as dressing agents in pulpotomized primary molars
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Erector Spinae (ESP) Block on Opioid Reduction and Enhanced Recovery After Posterior Cervical Spine Surgery
Status: RECRUITING
Conditions: Postoperative|Pain
Interventions: DRUG: Erector Spinae (ESP) Block with Lidocaine/Bupivacaine|DRUG: Erector Spinae (ESP) Block with placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study That Uses Data From Routine Eye Examinations of Patients Participating in Studies FIDELIO-DKD and FIGARO-DKD to Explore Whether Finerenone Can Delay the Progression of a Diabetes Complication That Affects the Eyes (Diabetic Retinopathy ,DR)
Status: COMPLETED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Finerenone (BAY94-8862)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Residual Gastric Area and Weight Loss After Sleeve Gastrectomy
Status: COMPLETED
Conditions: Obesity, Morbid
Interventions: DIAGNOSTIC_TEST: The radiographic images were collected through a software called "PACS" which combined with a viewer for image processing, that allows the calculation of the residual stomach area (RSA).
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Phase 1b Study of PUR1800 in Patients With COPD
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: DRUG: Placebo Comparator|DRUG: PUR1800 250 ug|DRUG: PUR1800 500 ug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Management on Patients Undergoing Lung Tumor Resection
Status: NOT_YET_RECRUITING
Conditions: Postoperative Pain|Lung Cancer|Lung Tumor
Interventions: DRUG: Dinalbuphine sebacate|DRUG: Analgesic injectables|DRUG: Enteral analgesics
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of BCX17725
Status: NOT_YET_RECRUITING
Conditions: Netherton Syndrome
Interventions: DRUG: BCX17725|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Bite Force Study of Two Marketed Adhesives Against no Adhesive
Status: COMPLETED
Conditions: Denture Retention
Interventions: OTHER: Test Product|OTHER: Positive Contol|OTHER: Negative Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety and Efficacy of Three Different Dosages of NewGam in Patients With Chronic Inflammatory Demyelinating Poly (Radiculo) Neuropathy
Status: COMPLETED
Conditions: Chronic Inflammatory Demyelinating Poly(Radiculo)Neuropathy
Interventions: DRUG: NewGam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoembolization in Treating Patients With Primary Liver Cancer or Metastases to the Liver
Status: COMPLETED
Conditions: Liver Cancer|Metastatic Cancer
Interventions: DRUG: cisplatin|DRUG: doxorubicin|DRUG: mitomycin|PROCEDURE: embolization
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pozelimab and Cemdisiran Combination Therapy in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Switch From Eculizumab Therapy
Status: COMPLETED
Conditions: Paroxysmal Nocturnal Hemoglobinuria
Interventions: DRUG: Pozelimab|DRUG: Cemdisiran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Nitric Oxide in Cirrhosis: Relationship With Systemic Hemodynamics, Renal Function, Vasoactive Systems and Endotoxemia
Status: UNKNOWN
Conditions: Cirrhosis|Liver Cirrhosis
Interventions: DRUG: N-monomethyl-L-arginine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Transcranial Magnetic Stimulation and Anti-epileptic Effect: Optimization and Evaluation With Electrophysiology.
Status: COMPLETED
Conditions: Refractory Frontal Lobe Epilepsy
Interventions: DEVICE: cortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: "Effectiveness of Basic Nursing Educational Interventions on Primary Healthcare Paramedics: A Quasi-Experimental Approach"
Status: RECRUITING
Conditions: Education Training|Nursing Skills|Primary Healthcare|Education, Nursing
Interventions: OTHER: Intervention Basic Nursing skills|OTHER: Control Present Knowledge about basic nursing skill
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: SCT200 in Combination With SCT-I10A/Paclitaxel/Docetaxel in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Status: UNKNOWN
Conditions: Head and Neck Squamous Carcinoma
Interventions: DRUG: SCT-I10A|DRUG: SCT200|DRUG: paclitaxel|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Compare the Safety, Tolerability, and PK Properties of DA-5216 and DA-5216-R and to Evaluate the Food Effect on DA-5216.
Status: UNKNOWN
Conditions: Healthy
Interventions: DRUG: DA-5216|DRUG: DA-5216-R|DRUG: DA-5216|DRUG: DA-5216
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Elective Neck Irradiation Based on MRI in NPC Patients
Status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Interventions: RADIATION: Elective neck irradiation|RADIATION: Whole neck irradiation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase III Trial Of Docetaxel Versus Docetaxel Plus ZD1839 In Head And Neck Cancer
Status: TERMINATED
Conditions: Recurrent Head and Neck Cancer|Metastatic Head and Neck Cancer
Interventions: DRUG: docetaxel|OTHER: placebo|DRUG: gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Impact of Almond Supplementation on Body Composition in Overweight/Obese Minority Adults
Status: COMPLETED
Conditions: Obesity|Overweight|Fatty Liver|Metabolic Syndrome X
Interventions: DIETARY_SUPPLEMENT: Almond|DIETARY_SUPPLEMENT: Cereal Bar
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Comparative Phase IV Study Evaluating Efficacy & Safety Of Magnex(Cefoperazone-Sulbactam) In Intraabdominal Infections
Status: COMPLETED
Conditions: Infection
Interventions: DRUG: Magnex (Sulbactam Sodium/Cefoperazone Sodium 1:1) Pfizer Ltd.|DRUG: Fortum (Ceftazidime for injection USP) Glaxo Smith Kline Pharmaceuticals Limited|DRUG: Metrogyl (Metronidazole Injection IP) J.B.Chemicals & Pharmaceuticals Ltd.|DRUG: Mikacin (Amikacin Sulphate Injection IP) Aristo Pharmaceuticals Ltd.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Five Fractions of Radiotherapy Followed by Full Dose FOLFOX Chemotherapy as Preoperative Treatment for Rectal Cancer
Status: COMPLETED
Conditions: Rectal Neoplasms
Interventions: RADIATION: External beam radiation|DRUG: Oxaliplatin|DRUG: Leucovorin|DRUG: 5-FU|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT