pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: A Study Of PF-00547659 In Patients With Moderate To Severe Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Placebo|DRUG: PF-00547659 SC Injection|DRUG: PF-00547659 SC Injection|DRUG: PF-00547659 SC Injection|DRUG: PF-00547659 SC Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer
Status: COMPLETED
Conditions: Extensive Stage Small Cell Lung Cancer|Recurrent Small Cell Lung Cancer
Interventions: DRUG: R-(-)-gossypol acetic acid|OTHER: pharmacological study|OTHER: laboratory biomarker analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Action Observation Plus Sonification Therapeutic Protocol
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: AO - plus sonification|BEHAVIORAL: CUE - visual and auditory
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone
Status: COMPLETED
Conditions: Esotropia|Exotropia
Interventions: DRUG: Botulinum Toxin Type A|DRUG: saline solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparative Clinical Trial of Efficacy and Safety of BCD-057 and Humira® in Patients With Moderate to Severe Plaque Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: BCD-057|BIOLOGICAL: Humira®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Double-blind Study of E2020 (Donepezil Hydrochloride) in Patients With Dementia With Lewy Bodies (DLB) (Study E2020-J081-431)
Status: COMPLETED
Conditions: Dementia With Lewy Bodies (DLB)
Interventions: DRUG: 3 mg Donepezil hydrochloride|DRUG: 5 mg Donepezil hydrochloride|DRUG: 10 mg Donepezil hydrochloride|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Proving Hemodilution in a Human Model for Class I Hemorrhage
Status: COMPLETED
Conditions: Hemodilution|Hemorrhage|Shock|Wounds and Injuries
Interventions: OTHER: normal saline|OTHER: lactated ringers
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Unresectable or Metastatic Melanoma
Status: RECRUITING
Conditions: Melanoma
Interventions: DRUG: ABP 206|DRUG: Nivolumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Pain Relief During Intravenous Cannulation in Pediatric Patients
Status: COMPLETED
Conditions: Cannula Site Pain|Local Anesthesia
Interventions: DRUG: Xylocaine 10% Oral|DRUG: Placebo- Serum Fizyolojik Izotonik 0,9% 10 ml ampul
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Endostar Treatment of Advanced Non-small Cell Lung Cancer Multi-center Clinical Research
Status: UNKNOWN
Conditions: Non-small Cell Lung Cancer
Interventions: BIOLOGICAL: Endostar|DRUG: Changchun marina|DRUG: cisplatin|DRUG: Taxol|DRUG: parapl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 1064-nm Q-switched Nd:YAG Laser and Intradermal Tranexamic Acid for Melasma
Status: UNKNOWN
Conditions: Melasma
Interventions: PROCEDURE: intradermal tranexamic acid|DEVICE: Nd-YAG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior
Status: ENROLLING_BY_INVITATION
Conditions: Fatigue; Muscle, Heart|Fatigue, Mental
Interventions: OTHER: Oral Pouch - Nicotine|OTHER: Oral Pouch - Caffeine|OTHER: Oral Pouch - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Study of Taurine Combined With Sintilimab and Chemotherapy for Treatment of Advanced Gastric Cancer
Status: RECRUITING
Conditions: Gastric Cancer
Interventions: DIETARY_SUPPLEMENT: Taurine|BIOLOGICAL: Sintilimab|DRUG: XELOX regimen|DRUG: SOX regimen|DRUG: FOLFOX regimen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)
Status: ACTIVE_NOT_RECRUITING
Conditions: Lymphoma, Mantle-Cell
Interventions: DRUG: Pirtobrutinib|DRUG: Ibrutinib|DRUG: Acalabrutinib|DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tocilizumab in the Management of Juvenile Idiopathic Arthritis Associated Uveitis
Status: TERMINATED
Conditions: Juvenile Idiopathic Arthritis Associated Uveitis
Interventions: DRUG: Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiological, Behavioral and Subjective Effects of Drugs (GHB)
Status: COMPLETED
Conditions: Sedative Abuse
Interventions: DRUG: sodium oxybate, triazolam and pentobarbital
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Radiofrequency vs Cryoballoon Ablation for Atrial Fibrillation Assessed by Implantable Cardiac Monitor
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: Radiofrequency ablation|PROCEDURE: Cryoballoon ablation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Self- Administered Acupressure for Diarrhea Predominant Irritable Bowel Syndrome
Status: COMPLETED
Conditions: Irritable Bowel Syndrome With Diarrhea
Interventions: OTHER: Active acupressure|OTHER: Sham acuptressure
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Mapatumumab in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: BIOLOGICAL: mapatumumab|DRUG: sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of a Melatonin Supplementation on the Quality of Life in Elderly Metastatic Cancer Patients
Status: TERMINATED
Conditions: Cancer
Interventions: DRUG: melatonin|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of LimpiAD Cream 2.5% Plus Versus Vehicle and an Emollient in Patients With Atopic Dermatitis
Status: RECRUITING
Conditions: Atopic Dermatitis
Interventions: DEVICE: LimpiAD cream 2,5% plus|OTHER: Vehicle|OTHER: Emollient
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Constraints Induced Movement Therapy Versus Mirror Therapy in Children With Hemiplegic Cerebral Palsy
Status: COMPLETED
Conditions: Cerebral Palsy|Hemiplegic Cerebral Palsy
Interventions: OTHER: Constraint Induced Movement Therapy (CIMT)|OTHER: Mirror Therapy (MT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Short Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine
Status: COMPLETED
Conditions: Hyperbaric Oxygen Therapy|Diabetic Foot Ulcer|Type II Diabetes Mellitus
Interventions: OTHER: Hyperbaric Oxygen Therapy (HBOT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)
Status: ACTIVE_NOT_RECRUITING
Conditions: Leiomyosarcoma
Interventions: DRUG: Unesbulin|DRUG: Dacarbazine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of SSP-004184 (FBS0701) in Healthy Adults and Elderly Subjects and in Subjects With Impaired Renal Function
Status: COMPLETED
Conditions: Impaired Renal Function
Interventions: DRUG: SSP-004184
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuromuscular Training Compared to Progressive Resistance Training for Patients With Anterior Knee Pain
Status: RECRUITING
Conditions: Anterior Knee Pain Syndrome
Interventions: OTHER: Neuromuscular Training exercises|OTHER: Hip and Knee Muscular Strength exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee
Status: TERMINATED
Conditions: Osteoarthritis
Interventions: DRUG: PLA-695
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Classic Cesarean Section Versus Minimally Invasive Cesarean Section: Pain Assessment
Status: COMPLETED
Conditions: Pregnancy
Interventions: PROCEDURE: Pfannenstiel cesarean section|PROCEDURE: Misgav-Ladach cesarean section
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 2 Clinical Proof-of-Concept Study of the Cardioprotective Properties of Danegaptide in ST Segment Elevation Myocardial Infarction
Status: COMPLETED
Conditions: Focus of Study is STEMI
Interventions: DRUG: danegaptide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin Plus Topotecan in Treating Patients With Relapsed Acute Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: carboplatin|DRUG: topotecan hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open-label Phase 3 Study of Lutetium (177Lu) Oxodotreotide Injection in Subjects With Advanced Gastrointestinal Pancreatic Neuroendocrine Tumors.
Status: RECRUITING
Conditions: Advanced Gastroenteropancreatic Neuroendocrine Tumor
Interventions: DRUG: Lutetium (177Lu) Oxodotreotide Injection；long-acting Octreotide|DRUG: long-acting Octreotide.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparing Single Versus Repeat NMT on the Diversity of the Neonatal Nasal Microbiome
Status: NOT_YET_RECRUITING
Conditions: Staphylococcus Aureus|Microbial Colonization|Neonatal Infection
Interventions: BIOLOGICAL: Nasal Microbiota Transplant (NMT)|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effect of HFA - Beclomethasone Dipropionate Qvar on Bronchial Hyperreactivity in Preschool Children
Status: COMPLETED
Conditions: Asthma|Bronchial Hyperresponsiveness
Interventions: DRUG: Beclomethasone dipropionate HFA|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Cocoa on Gastrointestinal Function
Status: COMPLETED
Conditions: Gastrointestinal and Digestive Disorder
Interventions: DIETARY_SUPPLEMENT: Dark chocolate bar|DIETARY_SUPPLEMENT: Dark chocolate mousse|DIETARY_SUPPLEMENT: White chocolate bar|DIETARY_SUPPLEMENT: White chocolate mousse
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of BCG on Influenza Induced Immune Response
Status: COMPLETED
Conditions: Influenza Virus Infection|Trained Immunity
Interventions: OTHER: Placebo|BIOLOGICAL: BCG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Multicentric Comparative Prospective Study of the Benefits and Risks of Biopsy Prostate Using Transrectal or Transperineal Procedure for the Prostate Cancer Diagnostic
Status: RECRUITING
Conditions: Patients With Suspected Prostate Cancer
Interventions: PROCEDURE: Biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Does NMES Help Relieve Lower Limb Oedema and Improve Joint Mobility and Skin Tissue Oxygenation Levels?
Status: UNKNOWN
Conditions: Oedema
Interventions: DEVICE: Custom-built, two-channel stimulator
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Practical Body Image Therapy for Anorexia Nervosa V1
Status: COMPLETED
Conditions: Body Image|Exposure
Interventions: OTHER: Practical Body Image (session 1 - 7)|OTHER: Practical Body Image (session 8 - 14)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Lomitapide in Healthy Subjects.
Status: COMPLETED
Conditions: Effect of Atorvastatin on the Pharmacokinetics of Lomitapide
Interventions: DRUG: lomitapide|DRUG: Atorvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Impact of Pre-operative Penicillin Allergy Evaluation on Surgical Prophylaxis
Status: RECRUITING
Conditions: Penicillin Allergy|Surgical Prophylaxis
Interventions: PROCEDURE: Detailed penicillin allergy evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Initial Feasibility Study to Integrate MRI Based Brachytherapy and CT/MR Fused INRT in Treatment of Advance Cervical Cancer
Status: WITHDRAWN
Conditions: Integrated MRI Based RT as Standard of Care|Locally Advanced Cervical Cancer
Interventions: RADIATION: Gold seeds insertion to detect movements at pelvis|RADIATION: Image guided MRI based RT (IMRT+Brachytherapy)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: |Primary Purpose: TREATMENT
Clinical trial: Improving Goals of Care Discussion in Advanced Cancer Patients
Status: COMPLETED
Conditions: Primary Stage IV Hepatobiliary|Esophageal|Colorectal Cancer|Glioblastoma|Cancer of Stomach|Cancer of Pancreas|Melanoma|Head or Neck Cancer|Stage III|Stage IV|Lung Cancers|Pancreatic Cancers
Interventions: BEHAVIORAL: GoC intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Ledipasvir/Sofosbuvir Fixed-Dose Combination Plus Ribavirin in Participants With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant
Status: COMPLETED
Conditions: Chronic HCV Infection
Interventions: DRUG: LDV/SOF|DRUG: RBV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery
Status: RECRUITING
Conditions: Endothelial Dysfunction|Vascular Diseases|Kidney Injury|Brain Disease|Vascular Inflammation
Interventions: DRUG: Vericiguat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase I Imaging Study Evaluating Gem/Cis or Gem/Carbo for Participants With Non-Small Cell Lung Cancer (MK-0000-083 AM3)
Status: COMPLETED
Conditions: Carcinoma|Non-small Cell Lung Cancer
Interventions: RADIATION: Comparator: CT or MRI and FDG-PET|DRUG: Gemcitabine and Cisplatin or Gemcitabine and Carboplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Randomized, Double-Blind Trial Comparing the Efficacy and Safety of Fenofibrate, Metformin, Their Combination and Placebo in Patients With Metabolic Syndrome.
Status: COMPLETED
Conditions: Patients With Metabolic Syndrome
Interventions: DRUG: Fenofibrate /Metformin|DRUG: Fenofibrate /Metformin|DRUG: Fenofibrate /Metformin|DRUG: Fenofibrate /Metformin|DRUG: Fenofibrate /Metformin|DRUG: Fenofibrate /Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of 5 Weeks Treatment With Dapagliflozin in Type 2 Diabetes Patients on How the Hormone Insulin Acts on Sugar Uptake in Muscles.
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Skeletal Muscle Insulin Sensitivity
Interventions: DRUG: Dapagliflozin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postoperative Supplemental Oxygen in Liver Transplantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Infection
Interventions: PROCEDURE: 80% fraction of inspired oxygen for 6 postoperative hours|PROCEDURE: 28% fraction of inspired oxygen for 6 postoperative hours
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A RCT to Evaluate the Effects of Pelvic and Abdominal Mechanical Exercises During Pregnancy on Reducing the Rate of CS and Preventing PFD
Status: UNKNOWN
Conditions: Mode of Delivery|Pelvic Floor Dysfunction
Interventions: BEHAVIORAL: pelvic and abdominal mechanics exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: CDK4/6 Inhibitor Plus Camrelizumab for PD-1 Inhibitor Refractory R/M NPC
Status: RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Dalpiciclib Isetionate Tablets, Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tumor Samples in Patients Undergoing Treatment for Gastrointestinal Stromal Tumors on Clinical Trial ACOSOG-Z9001
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumor
Interventions: GENETIC: mutation analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Selective Retina Therapy (SRT) for Clinically Significant Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DEVICE: selective retina therapy (SRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIIB023 Proof-of-Concept Study in Participants With Lupus Nephritis
Status: TERMINATED
Conditions: Lupus Nephritis
Interventions: BIOLOGICAL: BIIB023|BIOLOGICAL: Placebo|DRUG: mycophenolate mofetil|DRUG: oral corticosteroids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety and Immunogenicity of Monovalent OPV2 in Children Aged 1 to 5 Years in Lithuania
Status: COMPLETED
Conditions: Poliomyelitis
Interventions: BIOLOGICAL: Sabin mOPV2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effects on Hemostasis, Lipids, Carbohydrate Metabolism, Adrenal & Thyroid Function of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG-EE (292004)(COMPLETED)(P05764)
Status: COMPLETED
Conditions: Contraception
Interventions: DRUG: NOMAC-E2|DRUG: Levonorgestrel and Ethinyl Estradiol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Micronized dHACM Injectable for the Treatment of Achille Tendonitis
Status: COMPLETED
Conditions: Tendonitis;Achilles
Interventions: BIOLOGICAL: Micronized DHACM|DRUG: Saline Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of a Prebiotic Supplement to Mitigate Excessive Weight Gain Among Physicians in Residency
Status: COMPLETED
Conditions: Weight Gain Trajectory|Metabolic Syndrome
Interventions: DIETARY_SUPPLEMENT: Prebiotin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Study of How MK-0736 Affects Arterial Plaque (0736-006)(TERMINATED)
Status: TERMINATED
Conditions: Peripheral Vascular Diseases
Interventions: DRUG: MK-0736|DRUG: Comparator: placebo (unspecified)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture Anesthesia for Nasal Sinus Surgery and Mammaplasty
Status: COMPLETED
Conditions: Therapeutic (Nonsurgical) and Rehabilitative Anesthesiology Devices Associated With Adverse Incidents
Interventions: PROCEDURE: non-electroacupuncture|PROCEDURE: Electroacupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate The Effects of RO5545965 in Participants With Negative Symptoms of Schizophrenia Treated With Antipsychotics
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Placebo|DRUG: RO5545965
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Phacogoniotomy in Medically-controlled POAG
Status: RECRUITING
Conditions: Glaucoma, Open-Angle|Cataract Complicated|Goniotomy
Interventions: PROCEDURE: PEI+GT|PROCEDURE: PEI+MED
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Voriconazole and Caspofungin Acetate in Treating Invasive Fungal Infections in Patients With Weakened Immune Systems
Status: TERMINATED
Conditions: Infection|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: caspofungin acetate|DRUG: voriconazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of Sealing Ability of MTA and Biodentine for Repairing of Furcal Perforation in Primary Molars
Status: UNKNOWN
Conditions: Tooth Injuries
Interventions: COMBINATION_PRODUCT: Mineral Trioxide Aggregate|COMBINATION_PRODUCT: Biodentine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open-Label Phase I/II Study of Recombinant Granulocyte Colony Stimulating Factor (r-metHuG-CSF) and Recombinant Erythropoietin (rHuEPO) Given Subcutaneously Along With Zidovudine (AZT) to Patients With the Acquired Immune Deficiency Syndrome (AIDS) or Severe AIDS-Related Complex (ARC)
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Filgrastim|DRUG: Epoetin alfa|DRUG: Zidovudine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites
Status: COMPLETED
Conditions: Hepatic Ascites
Interventions: DRUG: Oral standard diuretics therapy|DRUG: Hypertonic saline solution|DRUG: Etilefrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Primary Clinical Evaluation of Wearable Filtrating Artificial Kidney Device for On-site Medical Rescue
Status: NOT_YET_RECRUITING
Conditions: Fluid Overload
Interventions: DEVICE: the wearable filtrating artificial Kidney Device|DEVICE: traditional hemodialysis machine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Oral Forodesine Hydrochloride (BCX-1777) in Patients With Recurrent or Refractory T/NK-cell Malignancies
Status: COMPLETED
Conditions: Recurrent or Refractory T/NK-cell Malignancies
Interventions: DRUG: forodesine hydrochloride|DRUG: forodesine hydrochloride|DRUG: forodesine hydrochloride|DRUG: forodesine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PLACENTEX ® i.m. in Patients With Scleroderma Diseases
Status: TERMINATED
Conditions: Scleroderma Disease
Interventions: DRUG: Polydeoxyribonucleotides
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Individual, Dyadic, and Collaborative Plans on Physical Activity in Patient-Partner Dyads
Status: WITHDRAWN
Conditions: Health Behavior
Interventions: BEHAVIORAL: Individual Planning|BEHAVIORAL: Dyadic Planning|BEHAVIORAL: Collaborative Planning|BEHAVIORAL: Education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Personalized Tumor Vaccines (PCVs) and a PD-L1 Blocker in Patients With Pancreatic Cancer That Can be Treated With Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Pancreatic Cancer
Interventions: DRUG: Atezolizumab|BIOLOGICAL: RO7198457|DRUG: mFOLFIRINOX
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Empagliflozin Add on to Linagliptin Study in Japanese Patient With Type 2 Diabetes Mellitus
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Linagliptin|DRUG: Empagliflozin placebo + linagliptin placebo low dose|DRUG: Empagliflozin + linagliptin low dose|DRUG: Linagliptin placebo|DRUG: Empagliflozin + linagliptin high dose|DRUG: Empa + lina highdose placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Masticatory Electrical Stimulation on Dysphagia in Spastic Cerebral Palsy
Status: COMPLETED
Conditions: Dysphagia
Interventions: OTHER: oromotor exercises and neuromuscular electrical stimulations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Bioavailability of Golden Rice Carotenoids in Humans
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: golden rice|DIETARY_SUPPLEMENT: corn oil 0g|DIETARY_SUPPLEMENT: corn oil 10g|DIETARY_SUPPLEMENT: coren oil 5 g
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Trial of Inserting Prevalence Information Into Lumbar Spine Imaging Reports
Status: COMPLETED
Conditions: Low Back Pain|Back Pain|Lumbar Pain|Backache
Interventions: OTHER: Epidemiologic benchmarks included in lumbar imaging reports
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy
Status: WITHDRAWN
Conditions: Cerebral Palsy|GERD
Interventions: DRUG: Baclofen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Aripiprazole in Children and Adolescents With Aspergers and Pervasive Developmental Disorder.
Status: COMPLETED
Conditions: Asperger's Disorder|Pervasive Developmental Disorder
Interventions: DRUG: aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sublingual Analgesia for Acute Abdominal Pain in Children
Status: COMPLETED
Conditions: Abdominal Pain
Interventions: DRUG: Ketorolac|DRUG: Tramadol|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MK2206 in Treating Patients With Advanced Liver Cancer That Did Not Respond to Previous Therapy
Status: TERMINATED
Conditions: Adult Hepatocellular Carcinoma|Advanced Adult Hepatocellular Carcinoma|Localized Non-Resectable Adult Liver Carcinoma|Recurrent Adult Liver Carcinoma
Interventions: DRUG: Akt Inhibitor MK2206|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: GlyT-1 Inhibitor Treatment for Refractory Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia|Treatment Refractory
Interventions: DRUG: GlyT-1 inhibitor-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Liraglutide in Type 2 Diabetes With Lower Extremity Arterial Disease
Status: UNKNOWN
Conditions: Type 2 Diabetes|Peripheral Vascular Disorder Due to Diabetes Mellitus
Interventions: DRUG: Liraglutide+standard-of-care treatment|OTHER: standard-of-care treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Use of the Neurolyser XR for the Treatment of Low Back Pain Related to Sacroiliitis
Status: NOT_YET_RECRUITING
Conditions: Sacroiliitis
Interventions: DEVICE: High-intensity focused ultrasound for Sacroiliitis using the Neurolyser XR
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of a Smartphone App for Adolescent Obesity Management
Status: UNKNOWN
Conditions: Obesity|Impaired Health|Psychosocial Problem|Physical Activity|General Nutrition Disorder
Interventions: BEHAVIORAL: W82GO|DEVICE: smartphone application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Rising-dose Study to Assess Tolerability, Safety, Pharmacokinetics, Pharmacodynamics of AR09
Status: TERMINATED
Conditions: Anesthesia
Interventions: DRUG: AR09 solution|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Safety, Pharmacokinetics and Pharmacodynamics of LGT209 in Healthy Volunteers With Elevated Cholesterol and in Hypercholesterolemic Patients Treated With Statins
Status: COMPLETED
Conditions: Hypercholesterolemia|LDL Cholesterol
Interventions: DRUG: LGT209 50 mg|DRUG: LGT209 300 mg|DRUG: Placebo|DRUG: Statins (atorvastatin or simvastatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Myofascial Induction Effects on Plantar Pressures and Stabilometry
Status: COMPLETED
Conditions: Foot Diseases|Myofascial Pain
Interventions: OTHER: Myofascial induction|OTHER: Sham myofascial induction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Obinutuzumab (RO5072759) Induction in Patients With Relapsed/ Refractory Waldenström Macroglobulinemia, OBI-1
Status: UNKNOWN
Conditions: Waldenstrom Macroglobulinemia
Interventions: DRUG: Obinutuzumab 25 MG/ML
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Endoscopic Visibility of Stomach After a Combination Drink of N-acetylcysteine and Simethicone
Status: NOT_YET_RECRUITING
Conditions: Gastric Disease
Interventions: DRUG: Evaluation of gastric visibility following the combination drink of N-acetyle cysteine and simethocone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Testing the Effectiveness of Different Messaging Approaches to Increase Doctor Visits Amongst Individuals With Risk Factors for Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes|Pre-diabetes
Interventions: BEHAVIORAL: Visit a doctor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SCREENING
Clinical trial: Antalgic Efficacy of CycloMesh™ Soaked in Ropivacaine Hydrochloride in Uncomplicated Inguinal Hernia.
Status: COMPLETED
Conditions: Inguinal Hernia
Interventions: PROCEDURE: Inguinal hernia repair with CycloMesh™ soaked in ropivacaine hydrochloride 10mg/mL|PROCEDURE: Inguinal hernia repair with CycloMesh™ soaked in saline solution NaCl 9°/°°
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy
Status: RECRUITING
Conditions: Cytokine Release Syndrome|ICANS|Lymphoma, Non-Hodgkin|Multiple Myeloma|Acute Lymphoblastic Leukemia
Interventions: DRUG: Siltuximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Investigate The Elimination Of PF-06273588 From The Body Following A Single Low Dose.
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-06273588|DRUG: PF-06273588
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Phase 1 Clinical Trial DHP2306R1 and DHP2306R2 in Healthy Adult Volunteers
Status: COMPLETED
Conditions: Musculoskeletal Pain
Interventions: DRUG: DHP2306R1|DRUG: DHP2306R2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of a Combination Intervention for Sustainable Blood Pressure Control
Status: RECRUITING
Conditions: Hypertension
Interventions: BEHAVIORAL: Community Health Worker Care Model|BEHAVIORAL: Enhanced Community Health Worker-based with Mobile Health Blood Pressure Monitoring Model|BEHAVIORAL: Standard of Care Model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
Status: RECRUITING
Conditions: Agitation in Patients With Dementia of the Alzheimer's Type
Interventions: DRUG: AVP-786|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prospective Comparative Analysis of ACDF vs Fusion Interbody Cages With nanoLOCK Osseointegrative Technology
Status: ENROLLING_BY_INVITATION
Conditions: Cervical Radiculopathy|Cervical Myelopathy
Interventions: DEVICE: Titan nanoLOCK interbody cage|DEVICE: ACDF interbody cage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Anterior Blepharitis With Microblepharoexfoliation Procedure
Status: TERMINATED
Conditions: Anterior Blepharitis
Interventions: DEVICE: Microblepharoexfoliative procedure with BlephEx™|PROCEDURE: Eyelid cleansing with eyelid wipes (Optase)|PROCEDURE: Daily eyelid cleansing with eyelid wipes (Optase)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-dose AZA Combined With Short Term CAG Derived Regimen as a Bridging Treatment in Patients With Advanced MDS Prior to Allo-HSCT
Status: UNKNOWN
Conditions: MDS-EB
Interventions: DRUG: Azacitidine|DRUG: CAG Protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Minimizing Doses of Antipsychotic Medication in Older Patients With Schizophrenia.
Status: COMPLETED
Conditions: Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Delusional Disorder|Psychotic Disorder
Interventions: DRUG: Risperidone/Olanzapine and PET scans
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MHB088C in Participants With Advanced or Metastatic Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: MHB088C for Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate LB-LR1109 for the Treatment of Solid Tumors
Status: NOT_YET_RECRUITING
Conditions: Non-small Cell Lung Cancer(NSCLC)|Head and Neck Squamous Cell Carcinoma(HNSCC)|Renal Cell Carcinoma(RCC)|Urothelial Carcinoma|Malignant Melanoma
Interventions: DRUG: LB-LR1109
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of MegaLT Injection for Treating Refractory Thrombocytopenia Following Radiotherapy, Chemotherapy, or Transplantation.
Status: NOT_YET_RECRUITING
Conditions: Refractory Thrombocytopenia
Interventions: BIOLOGICAL: MegaLT injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Pravastatin in Relapsing-remitting Multiple Sclerosis
Status: COMPLETED
Conditions: Relapsing-remitting Multiple Sclerosis
Interventions: DRUG: Pravastatin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Alteplase to Treat Blood Clots in Deep Leg Veins
Status: COMPLETED
Conditions: Acute Deep Venous Thrombosis of the Lower Extremity
Interventions: DRUG: Alteplase (Activase, Genentech)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of ADXS11-001 or MEDI4736 Alone or Combination In Cervical or Human Papillomavirus (HPV)+ Head & Neck Cancer
Status: TERMINATED
Conditions: Cervical Cancer|Cancer|Head and Neck Cancer
Interventions: DRUG: ADXS11-001|DRUG: MEDI4736
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Prevention of Dialysis Catheter Malfunction With Prophylactic Use of a Taurolidine Containing Urokinase
Status: COMPLETED
Conditions: Patency|Infection
Interventions: DRUG: Taurolidine Urokinase|DRUG: Taurolidine Heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase IB Dose Escalation Study of Lipocurc in Patients With Cancer
Status: COMPLETED
Conditions: Patients w/Advanced Cancer That Failed Std of Care Therapy
Interventions: DRUG: Liposomeal curcumin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of a Transvaginal Suture Capturing Mesh Device
Status: COMPLETED
Conditions: Surgical Repair of Middle Compartment Prolapse (Vaginal Vault or Uterine Prolapse) With or Without Cystocele
Interventions: PROCEDURE: Transvaginal suture capturing mesh device
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Masticatory Efficiency Between Complete Denture With Zero-degree Teeth and Anatomic Teeth in Patients With Severely Resorbed Ridge
Status: UNKNOWN
Conditions: Edentulous
Interventions: DEVICE: zero degree teeth|DEVICE: anatomic teeth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Evaluating the Safety and Efficacy of Rituximab in Patients With Myasthenia Gravis
Status: UNKNOWN
Conditions: Generalized Myasthenia Gravis
Interventions: DRUG: Rituximab|DRUG: Sodium Chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B)
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: ARV-471|DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Conventional vs. Robotic-assisted Laparoscopic Hysterectomy
Status: COMPLETED
Conditions: Uterine Fibroids, Menorrhagia, Endometriosis
Interventions: PROCEDURE: conventional laparoscopic hysterectomy|PROCEDURE: robotic assisted laparoscopic hysterectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Carcinoma, Squamous Cell|Head and Neck Neoplasms|Oropharyngeal Neoplasms
Interventions: RADIATION: Intensity Modulated Radiotherapy (IMRT)|DRUG: Cisplatin (or alternative)|PROCEDURE: Assessment for surgical evaluation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Retinal Vessel Analysis (rGA) at the Patient Bed in the Context of Non-traumatic Subarachnoid Haemorrhage
Status: UNKNOWN
Conditions: Non-traumatic Subarachnoid Haemorrhage
Interventions: DIAGNOSTIC_TEST: retinal vascular analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Technology-enabled Anticipatory Guidance and Peer Support in Empowering Parents to Prevent Early Childhood Caries
Status: RECRUITING
Conditions: Dental Caries|Dental Caries in Children|Diet Habit
Interventions: BEHAVIORAL: Technology-enabled anticipatory guidance and peer support|BEHAVIORAL: Conventional health education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Erythropoietin (EPO) to Protect Renal Function After Cardiac Surgery
Status: COMPLETED
Conditions: Kidney Failure|Renal Failure
Interventions: DRUG: Erythropoietin zeta|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Vaccine Booster (GEO-CM04S1) for the Prevention of COVID-19 in Patients With Chronic Lymphocytic Leukemia
Status: RECRUITING
Conditions: Chronic Lymphocytic Leukemia|COVID-19 Infection
Interventions: PROCEDURE: Biospecimen Collection|BIOLOGICAL: mRNA COVID-19 Vaccine|BIOLOGICAL: Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Cardiac Surgery|Cardiopulmonary Bypass
Interventions: BIOLOGICAL: AT-III (Human)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT