pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Mad Dog Cooking Class Series: Effects on Dietary Self-efficacy, Eating Behaviors and Health Outcomes
Status: NOT_YET_RECRUITING
Conditions: Spinal Cord Injuries|Multiple Sclerosis|Diet, Healthy|Inflammation|Depression|Adherence, Treatment
Interventions: OTHER: Mad Dog cooking class series
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Standard Treatment and Fusion Ontogenetic Surgery for Gynecologic Cancers
Status: RECRUITING
Conditions: Cervical Cancer|Uterine Cancer
Interventions: PROCEDURE: Cervical cancer|PROCEDURE: Uterine cancer|PROCEDURE: Cervical cancer, pelvic sidewall invasion|PROCEDURE: Non-cervical cancer, pelvic sidewall invasion
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Inspiratory Muscle Strength Training in Adults With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|Hypertension
Interventions: BEHAVIORAL: Inspiratory muscle strength training (IMST)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Reducing Residual Depressive Symptoms With Web-based Mindful Mood Balance
Status: COMPLETED
Conditions: Major Depressive Disorder, Recurrent, in Remission|Depressive Symptoms
Interventions: BEHAVIORAL: Usual Depression Care|BEHAVIORAL: Mindful Mood Balance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus
Status: COMPLETED
Conditions: Oral Lichen Planus
Interventions: DRUG: Prednisone tablet 5mg|DRUG: Omega-3 soft capsules 1000 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: SHERLOCK 3CG vs. Fluoroscopy in Implantation of PICC-Line
Status: COMPLETED
Conditions: Patients With PICC-Line
Interventions: DEVICE: PICC implantation under fluoroscopy|DEVICE: PICC Implantation under Sherlock System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The BLAST- 1 Trial - Cephalexin+Amoxicillin-clavulanate for Tuberculosis
Status: RECRUITING
Conditions: Tuberculosis, Pulmonary
Interventions: DRUG: Cephalexin|DRUG: Amoxicillin-Clavulanate 500 Mg-125 Mg Oral Tablet|OTHER: Standard of care treatment of tuberculosis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of CR6261 in an H1N1 Influenza Healthy Volunteer Human Challenge Model
Status: COMPLETED
Conditions: H1N1 Influenza Healthy Volunteers
Interventions: BIOLOGICAL: CR6261|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies
Status: COMPLETED
Conditions: Lung Transplant; Complications, Mechanical|Lung Transplant; Complications|Bleeding|Hemoptysis
Interventions: DRUG: Topical epinephrine|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Melphalan 200 mg/m2 Versus Melphalan 100 mg/m2 in Newly Diagnosed Myeloma Patients
Status: COMPLETED
Conditions: Multiple Myeloma|Diagnosis
Interventions: PROCEDURE: Autologous transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Fundamental Intelligent Building Blocks of the Intensive Care Unit (ICU) of the Future: Intelligent ICU of the Future
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain|Delirium
Interventions: OTHER: Video Monitoring|OTHER: Accelerometer Monitoring|OTHER: Electromyographic Monitoring|OTHER: Noise Level Monitoring|OTHER: Light Level Monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Garamycin® Sponge in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection
Status: COMPLETED
Conditions: Diabetic Foot Ulcer
Interventions: DRUG: Garamycin Sponge (Gentamicin-Collagen sponge)|DRUG: Systemic Antibiotic
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preservation of Ovarian Function After Hematopoietic Cell Transplant
Status: TERMINATED
Conditions: Multiple Myeloma|Non-Hodgkin Lymphoma|Hodgkin Disease|Acute Myeloid Leukemia|Myeloproliferative Disorders
Interventions: DRUG: Leuprolide|BIOLOGICAL: hematopoietic cell transplant|BIOLOGICAL: reduced intensity allogeneic HCT
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of COcoa Supplement in FRail Elderly Subjects (COFRE)
Status: COMPLETED
Conditions: Sarcopenia|Frail Elderly Syndrome
Interventions: OTHER: Placebo|OTHER: Flavonoids|DIETARY_SUPPLEMENT: No Flavonoids
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Referral Guidelines for Imaging Exams: Impact on Exam Relevance and Associated Delays
Status: COMPLETED
Conditions: Emergency Department Admission|Imaging Techniques
Interventions: OTHER: Implementation of guidelines|OTHER: Baseline observation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Central Vein Stenosis Due to Dialysis Catheter Insertion in Subclavian Compared to Jugular Vein
Status: RECRUITING
Conditions: Subclavian Vein Stenosis|Jugular Vein Occlusion
Interventions: PROCEDURE: Temporary central dialysis catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction
Status: ENROLLING_BY_INVITATION
Conditions: Anterior Cruciate Ligament Injury|Anterior Cruciate Ligament Rupture
Interventions: DEVICE: Autologous Bone Marrow Derived Mesenchymal Stem Cells|OTHER: Sham incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vitamin D and Osteoporosis Prevention in Elderly African American Women
Status: COMPLETED
Conditions: Determine Effect of Vitamin D on Bone Health in Elderly African American Women
Interventions: DIETARY_SUPPLEMENT: Vitamin D 3|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Exercise Training and Walking Ability After Chronic Stroke
Status: COMPLETED
Conditions: Stroke
Interventions: PROCEDURE: [A] Aerobic isokinetic cycling exercise|PROCEDURE: [B] Progressive Resistance Training|PROCEDURE: [A] + [B]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Efficacy of Lumateperone and Brain Glutamate and Dopamine
Status: TERMINATED
Conditions: Psychosis
Interventions: DRUG: Lumateperone|DRUG: Risperidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection
Status: COMPLETED
Conditions: Mycoses|Candidiasis|Aspergillosis|Cryptococcosis|Blastomycosis|Histoplasmosis|Neutropenia
Interventions: DRUG: ITCZ Oral Solution|DRUG: ITCZ-IV
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Anal Cancer and/or Precancer Screening: Performance Analysis of the BD Onclarity™ HPV Assay on Anal Specimens
Status: RECRUITING
Conditions: Anal Intraepithelial Neoplasia 2|Anal Intraepithelial Neoplasia 1|Anal Cancer|High-Risk Cancer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma
Status: COMPLETED
Conditions: Glioblastoma
Interventions: DRUG: 5-ALA|DRUG: Gliadel wafers|RADIATION: Radiotherapy as normal based on standard clinical protocols determined by the neuro-oncologist|DRUG: Concomitant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist|DRUG: Adjuvant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Oral Supplementation With Branched-Chain Amino Acids (BCAA) Improves Postoperative Quality of Life
Status: COMPLETED
Conditions: Hepatocellular Carcinoma|Chronic Liver Disease
Interventions: DRUG: Aminoleban EN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Evaluate Drug Levels of Various Solid Gastro-retentive Formulations of Deucravacitinib (BMS-986165) in Healthy Participants
Status: NOT_YET_RECRUITING
Conditions: Healthy Participants
Interventions: DRUG: Deucravacitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nilotinib Treatment-free Remission Study in CML (Chronic Myeloid Leukemia) Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Myelogenous Leukemia
Interventions: DRUG: Nilotinib followed by treatment-free
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effectiveness of Trauma-Focused Cognitive Behavioral Therapy in Treating Children With Post-Traumatic Stress Disorder
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: BEHAVIORAL: Trauma-focused cognitive behavioral therapy (TF-CBT)|BEHAVIORAL: Treatment as usual (TAU)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparing Efficacy of Azithromycin and Probiotics for Treatment of Acne Vulgaris
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Azithromycin|DRUG: Probiotic Formula|DRUG: Benzoyl Peroxide 4 % Topical Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety and Tolerability of AXA1125 and AXA1957 in Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)
Status: COMPLETED
Conditions: NAFLD
Interventions: DIETARY_SUPPLEMENT: AXA1957|DIETARY_SUPPLEMENT: AXA1125|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetic Characteristics of DWP16001 Drug A and C
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: DWP16001 Drug A|DRUG: DWP16001 Drug C
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients
Status: COMPLETED
Conditions: Peripheral Artery Disease|Intermittent Claudication
Interventions: BEHAVIORAL: Resistance training|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sulodexide on Albuminuria in Chinese Type 2 Diabetic Patients
Status: UNKNOWN
Conditions: Diabetic Nephropathy|Albuminuria
Interventions: DRUG: intravenous use of sulodexide followed by oral use|DRUG: use of sulodexide orally only
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Lactose Solution
Status: COMPLETED
Conditions: Lactose Intolerance
Interventions: DIETARY_SUPPLEMENT: Probiotic|DIETARY_SUPPLEMENT: Lactase|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Paravertebral Calcitonin in Thoracotomy
Status: RECRUITING
Conditions: Calcitonin|Paravertebral|Thoracotomy
Interventions: DRUG: bupivacaine-calcitonin-fentanyl|DRUG: Bupivacaine-fentanyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Afatinib and Paclitaxel in Patients With Advanced HER2-Positive Trastuzumab-Refractory Advanced Esophagogastric Cancer
Status: COMPLETED
Conditions: Esophageal Cancer|Gastric Cancer
Interventions: DRUG: Afatinib and Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Determining the True Incidence of Atrial Fibrillation Before and After Lung Resection
Status: TERMINATED
Conditions: Lung Cancer|Atrial Fibrillation|Stroke
Interventions: DEVICE: iRhythm ZIO XT patch
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: An Investigation Into Beneficial Effects of Interferon Beta 1a, Compared to Interferon Beta 1b And The Base Therapeutic Regiment in Moderate to Severe COVID-19: A Randomized Clinical Trial
Status: COMPLETED
Conditions: COVID-19
Interventions: DRUG: Hydroxychloroquine|DRUG: Lopinavir / Ritonavir|DRUG: Interferon Beta-1A|DRUG: Interferon Beta-1B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Buttressed Pancreatico-Gastrostomy for Soft Pancreas With Small Diameter Pancreatic Duct in Whipple Procedure
Status: COMPLETED
Conditions: Pancreatic Fistula
Interventions: PROCEDURE: Duct to Mucosa Pancreatico-Gastrostomy with trans-pancreatic transverse mattress U- Shaped sutures
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Primary Diagnosis Study for Validation of Hamamatsu NanoZoomer S360MD Digital Slide Scanner System
Status: COMPLETED
Conditions: Pathology
Interventions: DIAGNOSTIC_TEST: Whole Slide Imaging|DIAGNOSTIC_TEST: Light Microscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Evaluate the Effect of Nicotinamide Mononucleotide (NMN) As an Adjuvant to Standard of Care (SOC) On Fatigue Associated With COVID-19 Infection
Status: UNKNOWN
Conditions: COVID-19 Infection
Interventions: OTHER: Nicotinamide Mononucleotide|OTHER: Nicotinamide Mononucleotide with L-Leucine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Phase 1 Study of Anti-PD-L1 Monoclonal Antibody KN035 to Treat Locally Advanced or Metastatic Solid Tumors
Status: COMPLETED
Conditions: Solid Tumors
Interventions: DRUG: KN035
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Two Different Methods of Cryobiopsy in the Interstitial Lung Diseases
Status: ACTIVE_NOT_RECRUITING
Conditions: Interstitial Lung Disease
Interventions: PROCEDURE: Cryobiopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation
Status: UNKNOWN
Conditions: ICU Patients|Sedation
Interventions: DRUG: Dexmedetomidine|DRUG: Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Allergy Against Different Species of Fish in Children and Adolescents Allergic to Fish
Status: COMPLETED
Conditions: Fish Allergy
Interventions: OTHER: Cod_Double Blind Placebo Controlled Food Challenge|OTHER: Salmon_Double Blind Placebo Controlled Food Challenge|OTHER: Mackerel_Double Blind Placebo Controlled Food Challenge|OTHER: Placebo_Double Blind Placebo Controlled Food Challenge
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effect of Allopurinol Treatment on Insulin Resistance
Status: UNKNOWN
Conditions: Hyperuricemia|Prediabetes|Insulin Resistance
Interventions: DRUG: allopurinol 300 mg./day|OTHER: No intervention|DRUG: Normouricemic
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Randomized Clinical Trial of Adipose-derived Stem Cells in Treatment of Non Revascularizable Ischemic Myocardium
Status: COMPLETED
Conditions: Ischemic Heart Disease|Coronary Arteriosclerosis|Cardiovascular Disease|Coronary Disease|Coronary Artery Disease
Interventions: OTHER: Direct injection of ADRCs into the Left Ventricle|OTHER: Direct injection of placebo into the Left Ventricle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: In-home Use Test of the New Modified Diprobase Formulation to Assess the Safety and Tolerability in Infants and Children Under Physician's Control
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DEVICE: Modified Diprobase formulation (BAY987534)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Ipilimumab Versus Placebo to Prevent Recurrence After Complete Resection of High Risk Stage III Melanoma
Status: COMPLETED
Conditions: High Risk Stage III Melanoma
Interventions: DRUG: ipilimumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Compare PK, PD and Safety of the AD-213-A and AD-2131
Status: COMPLETED
Conditions: Gastroesophagus Reflux Disease
Interventions: DRUG: AD-213-A|DRUG: AD-2131
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Myofascial Release Therapy and Mechanical Neck Pain
Status: COMPLETED
Conditions: Neck Pain
Interventions: OTHER: Manual Therapy|OTHER: Myofascial Release Therapy|DEVICE: Analgesic therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Prediction of the Development of Heart Failure With Preserved Ejection Fraction
Status: UNKNOWN
Conditions: Heart Failure With Preserved Ejection Fraction
Interventions: DIAGNOSTIC_TEST: Assessment of the presence of heart failure with preserved ejection fraction, according to guideline recommendations from the European Society of Cardiology 2016
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FANCA Gene Transfer for Fanconi Anemia Using a High-safety, High-efficiency, Self-inactivating Lentiviral Vector
Status: UNKNOWN
Conditions: Fanconi Anemia
Interventions: GENETIC: Gene-modified autologous stem cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Digital Cognitive-behavioral Therapy for Insomnia for Patients With Multiple Sclerosis
Status: NOT_YET_RECRUITING
Conditions: Multiple Sclerosis|Insomnia
Interventions: BEHAVIORAL: i-CBT|BEHAVIORAL: Applied relaxation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thalidomide and Irinotecan in Treating Patients With Glioblastoma Multiforme Who Have Undergone Radiation Therapy
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors
Interventions: DRUG: irinotecan hydrochloride|DRUG: thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immediate Effects of Whole Body Vibration on Hemodynamic Response and Fatigue in Normotensive People With Obesity
Status: COMPLETED
Conditions: Obesity|Blood Pressure|Whole Body Vibration|Exercise
Interventions: OTHER: Whole Body Vibration Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of the GARFT Inhibitor AG2037 in Patients With Metastatic Colorectal Cancer Who Failed Treatment
Status: COMPLETED
Conditions: Colorectal Neoplasms
Interventions: DRUG: PELITREXOL/AG-2037
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Orion Lamina Cover in Patients Undergoing Lumbar Laminectomy With Instrumented Fusion
Status: COMPLETED
Conditions: Degenerative Lumbar Spinal Stenosis|Degenerative Spondylolisthesis|Spinal Stenosis|Scoliosis|Spinal Fracture
Interventions: DEVICE: Sham|DEVICE: ORION spinal lamina cover
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Dexamethasone Ophthalmic Insert (Dextenza®) in the Management of Clinically Significant Dry Eye
Status: TERMINATED
Conditions: Dry Eye
Interventions: DRUG: Sustained Release Dexamethasone, 0.4 mg|OTHER: E-Caprolactone-L-Lactide copolymer (PCL) punctal plug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Traditional Blind Versus Ultrasound-guided Peribulbar Blockade
Status: UNKNOWN
Conditions: Retinal and Infra-ocular Pathology
Interventions: PROCEDURE: Local Anaesthetic Injection|PROCEDURE: Ultrasound-Guidance
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of NN1250 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetes
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 1
Interventions: DRUG: insulin degludec|DRUG: insulin detemir|DRUG: insulin aspart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg
Status: UNKNOWN
Conditions: Contraception
Interventions: DRUG: Ulipristal Acetate|DRUG: Levonorgestrel|DRUG: Levonorgestrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Study of Key Electro-acupuncture Technique on Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DEVICE: electro-acupuncture|DRUG: flunarizine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3 Study of ProstAtak® Immunotherapy With Standard Radiation Therapy for Localized Prostate Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Prostate Cancer
Interventions: BIOLOGICAL: Aglatimagene besadenovec + valacyclovir|BIOLOGICAL: Placebo + valacyclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes
Status: COMPLETED
Conditions: Coronary Artery Disease (CAD)
Interventions: BEHAVIORAL: High Intensity Interval Training|BEHAVIORAL: Moderate Intensity Continuous Exercise Training|BEHAVIORAL: Nordic Walking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Multicentric Prospective Randomized Trial on Surgery Versus Standard Medical Care in Type 2 Diabetic Patients BMI 30-35
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: PROCEDURE: Bariatric surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Triheptanoin in Adults With McArdle Disease (Glycogen Storage Disease Type V)
Status: COMPLETED
Conditions: Glycogen Storage Disease Type V
Interventions: DRUG: Triheptanoin|OTHER: Placebo oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplant
Status: COMPLETED
Conditions: Acute Biphenotypic Leukemia|Acute Lymphoblastic Leukemia in Remission|Acute Myeloid Leukemia in Remission|Blasts Under 5 Percent of Bone Marrow Nucleated Cells|Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive|Myelodysplastic Syndrome (MDS)
Interventions: DRUG: Cyclosporine|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Mycophenolate Mofetil|RADIATION: Total-Body Irradiation|DRUG: Treosulfan|PROCEDURE: Umbilical Cord Blood Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy
Status: ENROLLING_BY_INVITATION
Conditions: Pain, Acute Postoperative|Renal Stone
Interventions: DRUG: Active bupivacaine 0.25% via an erector spinae plane perineural catheter|DRUG: Placebo normal saline via an erector spinae plane perineural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma
Status: COMPLETED
Conditions: Neuroblastoma
Interventions: BIOLOGICAL: filgrastim|BIOLOGICAL: sargramostim|DRUG: carboplatin|DRUG: cisplatin|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: etoposide phosphate|DRUG: ifosfamide|DRUG: isotretinoin|DRUG: melphalan|DRUG: thiotepa|DRUG: vincristine sulfate|PROCEDURE: conventional surgery|PROCEDURE: peripheral blood stem cell transplantation|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)
Status: RECRUITING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: BIOLOGICAL: Sacituzumab Govitecan|BIOLOGICAL: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using AI as a Diagnostic Decision Support Tool to Help the Diagnosis of Skin Disease in Primary Healthcare in Catalonia
Status: COMPLETED
Conditions: Skin Diseases
Interventions: DIAGNOSTIC_TEST: Autoderm® dermatology search engine (ML model) testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Evolution® Biliary Stent System Clinical Study
Status: COMPLETED
Conditions: Biliary Tract Neoplasms|Neoplasms|Gastrointestinal Diseases|Digestive System Diseases|Biliary Tract|Stents
Interventions: DEVICE: Evolution® Biliary Stent - Uncovered
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel in Patients With Acute Ankle Sprain
Status: COMPLETED
Conditions: Ankle Sprain
Interventions: DRUG: Diclofenac diethylamine 2.32% gel|DRUG: Placebo|DRUG: Diclofenac diethylamine 2.32% gel / Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD6615 in Healthy Subjects
Status: TERMINATED
Conditions: Dyslipidemia
Interventions: DRUG: AZD6615|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Magnesium Oxide Monohydrate for Nocturnal Leg Cramps
Status: TERMINATED
Conditions: Nocturnal Leg Cramps|Quality of Life
Interventions: DRUG: MAGNOX 520®|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Biomarkers in Blood and Bone Marrow Samples From Patients With Previously Untreated Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: fluorescence in situ hybridization|GENETIC: mutation analysis|GENETIC: nucleic acid sequencing|GENETIC: polymerase chain reaction|GENETIC: western blotting|OTHER: flow cytometry|OTHER: laboratory biomarker analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Use of Thromboelastometry (ROTEM) to Evaluate the Changes in Coagulation With Two Different Doses of Oxytocin Following Cesarean Delivery
Status: WITHDRAWN
Conditions: Coagulation Changes With Oxytocin
Interventions: DRUG: Oxytocin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors
Status: RECRUITING
Conditions: Unresectable or Metastatic Melanoma or Advanced Solid Tumors|Melanoma|Uveal Melanoma|P53 Mutation|MDM2 Gene Mutation|Cutaneous Melanoma|Mucosal Melanoma|Malignant Peripheral Nerve Sheath Tumors (MPNST)
Interventions: DRUG: Phase 1b: APG-115+pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety Study of Dapivirine (TMC120) Vaginal Microbicide Gel in South Africa
Status: WITHDRAWN
Conditions: HIV Infections
Interventions: DRUG: dapivirine (TMC120) vaginal gel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Ventilation Strategy During General Anesthesia for Orthopedic Surgery
Status: COMPLETED
Conditions: Orthopedic Surgery|Ventilation
Interventions: PROCEDURE: Low tidal Volume|PROCEDURE: High tidal Volume|PROCEDURE: Low PEEP|PROCEDURE: High PEEP
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer
Status: COMPLETED
Conditions: Brain and Central Nervous System Tumors|Breast Cancer|Gastrointestinal Carcinoid Tumor|Islet Cell Tumor|Lung Cancer|Lymphoma|Melanoma (Skin)|Neoplastic Syndrome
Interventions: RADIATION: yttrium Y 90-edotreotide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Leukemia|Acute Myeloid Leukemia|Acute Lymphoblastic Leukemia/Lymphoma|Burkitt's Lymphoma|Natural Killer Cell Malignancies|Chronic Myelogenous Leukemia|Myelodysplastic Syndrome|Large-cell Lymphoma|Hodgkin Lymphoma|Multiple Myeloma|Relapsed Chronic Lymphocytic Leukemia|Relapsed Small Lymphocytic Lymphoma|Marginal Zone B-cell Lymphoma|Follicular Lymphoma|Lymphoplasmacytic Lymphoma|Mantle-cell Lymphoma|Prolymphocytic Leukemia|Bone Marrow Failure Syndromes|Myeloproliferative Neoplasms/Myelofibrosis|Biphenotypic/Undifferentiated/Prolymphocytic Leukemias|MRD Positive Leukemia|Leukemia or MDS in Aplasia|Relapsed T-Cell Lymphoma|Relapsed Multiple Myeloma|Plasma Cell Leukemia
Interventions: DRUG: Fludarabine|DRUG: Cyclophosphamide|DRUG: MMF|DRUG: Sirolimus|RADIATION: TBI|BIOLOGICAL: Umbilical cord blood cell infusion|BIOLOGICAL: ATG
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of BG00012 (Dimethyl Fumarate) in Asian Subjects With Relapsing Remitting Multiple Sclerosis (RRMS)
Status: COMPLETED
Conditions: Relapsing-Remitting Multiple Sclerosis|Multiple Sclerosis
Interventions: DRUG: Placebo|DRUG: dimethyl fumarate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Expanding the Biomarkers in Familial Amyloid Neuropathy: MRI and Motor Unit Estimation by Electrophysiological Study
Status: COMPLETED
Conditions: Amyloid Neuropathies|Transthyretin Amyloidosis
Interventions: OTHER: Electrophysiological biomarkers|OTHER: MRI biomarkers
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Exercise to Treat Depression in Individuals With Coronary Heart Disease
Status: COMPLETED
Conditions: Depression|Heart Diseases
Interventions: BEHAVIORAL: Supervised Aerobic Exercise|DRUG: Sertraline|DRUG: Placebo Pill.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Interaction With HIV Antiretroviral Agents
Status: COMPLETED
Conditions: HIV-DDI
Interventions: DRUG: Riociguat (Adempas, BAY 63-2521)|DRUG: ATRIPLA|DRUG: COMPLERA|DRUG: STRIBILD|DRUG: TRIUMEQ|DRUG: Antiretroviral protease inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors
Status: COMPLETED
Conditions: Kidney Cancer|Leukemia|Lymphoma|Neurotoxicity|Peripheral Neuropathy|Sarcoma
Interventions: DRUG: Glutamine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Efficacy and Safety Study of RPT193 in Adults With Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis
Interventions: DRUG: RPT193|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of Nimotuzumab in Patients With Solid Tumors
Status: UNKNOWN
Conditions: Solid Tumors
Interventions: DRUG: Nimotuzumab|DRUG: irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Family Startup Program. A Randomized Controlled Trial of a Universal Group-based Parenting Support Program
Status: UNKNOWN
Conditions: First-time Pregnant Women and Their Partners
Interventions: OTHER: Family Startup (in Danish: Familieiværksætterne)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Sevuparin/DF02 as an Adjunctive Therapy in Subjects Affected With Uncomplicated Falciparum Malaria
Status: TERMINATED
Conditions: Malaria, Falciparum
Interventions: DRUG: Sevuparin sodium + atovaquone/proquanil|DRUG: atovaquone/proquanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Patient Reported Outcome Measures (PROMs) in Rehabilitation With or Without the Possible Use of a Mobile Application After Primary Knee or Hip Arthroplasty
Status: COMPLETED
Conditions: Arthroplasty, Replacement, Knee|Rehabilitation|Hip Arthrosis
Interventions: DEVICE: moveUp|OTHER: Predefined number of traditional physiotherapy sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biological Factors in Predicting Response to Treatment in Patients With Esophageal Cancer or Rectal Cancer
Status: COMPLETED
Conditions: Colorectal Cancer|Esophageal Cancer
Interventions: GENETIC: gene expression analysis|GENETIC: mutation analysis|GENETIC: polymorphism analysis|OTHER: laboratory biomarker analysis|PROCEDURE: biopsy|PROCEDURE: endoscopic biopsy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: DIAGNOSTIC
Clinical trial: Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in de Novo Kidney Transplant Recipients
Status: NOT_YET_RECRUITING
Conditions: Kidney Transplant Rejection
Interventions: DRUG: Enteric-Coated Mycophenolate Sodium (EC-MPS)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate Exemestane Tablets Combined With Ovarian Function Suppression/Ablation in Treatment of Premenopausal Breast Cancer Patients With CYP2D6*10 Mutations （STEP）
Status: UNKNOWN
Conditions: CYP2D6 Polymorphism
Interventions: DRUG: Exemestane Tablets|OTHER: ovarian function suppression/ablation|GENETIC: CYP2D6*10 gene test|DRUG: Tamoxifen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence
Status: COMPLETED
Conditions: Cocaine Dependence
Interventions: DRUG: acamprosate|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein C
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: Recombinant Activated Protein C|DEVICE: Near-infrared spectroscopy (NIRS)|DRUG: Phenylephrine|BIOLOGICAL: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neuroprotection With Dexmedetomidine in Patients Undergoing Elective Cardiac or Abdominal Surgery (Neuprodex)
Status: COMPLETED
Conditions: Delirium|Postoperative Cognitive Deficit (POCD)
Interventions: DRUG: Dexmedetomidine (Dexdor®)|DRUG: 0.9% Sodium Chloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combination Chemotherapy Followed By Radiation Therapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: filgrastim|DRUG: EPOCH regimen|DRUG: cyclophosphamide|DRUG: doxorubicin hydrochloride|DRUG: etoposide|DRUG: prednisone|DRUG: vincristine sulfate|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study of Single-Agent Lenalidomide in Subjects With Relapsed Or Refractory T-Cell Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: T-cell Non-Hodgkin's Lymphoma
Interventions: DRUG: Lenalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of VYNT-0126 in the Treatment of Rett Syndrome in Adult Patients
Status: NOT_YET_RECRUITING
Conditions: Rett Syndrome
Interventions: DRUG: VYNT-0126|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Cognition in People With Progressive Multiple Sclerosis Using Aerobic Exercise and Cognitive Rehabilitation
Status: COMPLETED
Conditions: Multiple Sclerosis, Primary Progressive|Cognitive Impairment
Interventions: OTHER: Cognitive Rehabilitation|OTHER: Sham Exercise|OTHER: Sham Cognitive Rehabilitation|OTHER: Aerobic Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Immune Responses to COVID-19 Vaccination in Lymphoma Patients
Status: COMPLETED
Conditions: Classical Hodgkin Lymphoma|Diffuse Large B Cell Lymphoma|Primary Mediastinal B Cell Lymphoma|High-grade B-cell Lymphoma|Burkitt Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma|Lymphoplasmacytic Lymphoma|Nodular Lymphocyte Predominant Hodgkin Lymphoma|Peripheral T-cell Lymphoma
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Effects of Different PEEP Values With USG on Optic Nerve Sheath Diameter
Status: NOT_YET_RECRUITING
Conditions: Cholecystitis
Interventions: OTHER: insufflation|OTHER: desufflation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Of Percutaneous Mechanical Thrombectomy With Different Access in Treatment of Acute Deep Venous Thrombosis
Status: RECRUITING
Conditions: Deep Vein Thrombosis
Interventions: PROCEDURE: Percutaneous mechanical thrombectomy (PMT) by the modified approach|PROCEDURE: Percutaneous mechanical thrombectomy (PMT) by the traditional approach
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT
Status: RECRUITING
Conditions: Thrombosis, Deep Vein|Iliofemoral; Thrombosis
Interventions: COMBINATION_PRODUCT: Perivascular dexamethasone|COMBINATION_PRODUCT: Perivascular sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Proof of Mechanism Study to Evaluate Binding of Alfa-synuclein
Status: UNKNOWN
Conditions: Parkinson Disease|Multisystem Atrophy|Healthy Volunteer
Interventions: DRUG: [18F]UCB-2897
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Colchicine in Patients With Mild and Severe Coronavirus Disease
Status: TERMINATED
Conditions: COVID
Interventions: DRUG: Colchicine|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
Status: COMPLETED
Conditions: Colitis|HIV Infections
Interventions: DRUG: Glutamic acid hydrochloride|DRUG: Ganciclovir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Open-Label, Bridging Study of Telaprevir in Treatment-Naïve and Treatment-Experienced Russian Patients With Genotype 1 Chronic Hepatitis C
Status: COMPLETED
Conditions: Genotype 1 Chronic Hepatitis C
Interventions: DRUG: Telaprevir|DRUG: Pegylated-interferon-alfa-2a|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Selenium Sulfide, Ketoconazole and Ciclopirox Shampoo as Additional Treatments for Tinea Capitis (Scalp Ringworm)
Status: COMPLETED
Conditions: Tinea Capitis
Interventions: DRUG: oral griseofulvin, selenium sulfide shampoo 1%, ciclopirox shampoo , ketoconazole shampoo 2%, baby shampoo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT