pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Phase II Study of Nivolumab in Combination With Relatlimab in Patients With Active Melanoma Brain Metastases
Status: RECRUITING
Conditions: Melanoma (Skin)
Interventions: DRUG: BMS-986213 (Relatlimab-Nivolumab FDC)|DRUG: Nivolumab|DRUG: Relatlimab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Regular Exercise on Improving Sleep in Older Adults
Status: COMPLETED
Conditions: Sleep Initiation and Maintenance Disorders|Sleep Disorders, Intrinsic
Interventions: BEHAVIORAL: Moderate-Intensity Aerobic Physical Activity|BEHAVIORAL: Health Education Class
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Characterization Of The Effect Of Food On Palbociclib (PD-0332991) Absorption
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Palbociclib administered Fasted|DRUG: Palbociclib administered Fed high calorie|DRUG: Palbociclib administered Fed low calorie|DRUG: Palbociclib administered Fed moderate calorie
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Randomized Study of the Safety and Effectiveness of the TearCare System for the Signs and Symptoms of Dry Eye Disease
Status: TERMINATED
Conditions: Dry Eye Syndromes
Interventions: DEVICE: TearCare|DEVICE: Warm Compress and Lid Massage
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Starzl Network Patient Reported Outcomes
Status: ACTIVE_NOT_RECRUITING
Conditions: Liver Transplant; Complications|Quality of Life|Child Behavior|Adolescent Behavior
Interventions: BEHAVIORAL: PeLTQL delivery via electronic means
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Vitamin D Supplementation in Children With Sickle Cell Disease
Status: COMPLETED
Conditions: Sickle Cell Disease
Interventions: DIETARY_SUPPLEMENT: Vitamin D bolus|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Thorough QT Study to Evaluate the Effect of Rodatristat Ethyl, Rodatristat and Its Major Metabolites on the Heart
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Rodatristat Ethyl|DRUG: Moxifloxacin|DRUG: Placebo for Rodatristat|DRUG: Placebo for Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: CONTINuous Infra-Inguinal Stenting Using the Bard® LifeStent® VascUlar Stent SysteMs ("CONTINUUM")
Status: TERMINATED
Conditions: Superficial Femoral Artery Stenosis
Interventions: DEVICE: PTA followed by placement of LifeStent® Vascular Stent
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video-based Teach-to-goal Intervention on Inhaler Technique on Jordanian Adults With Asthma and COPD
Status: COMPLETED
Conditions: COPD|Asthma|Inhaled Steroid Dependent Asthma
Interventions: BEHAVIORAL: Verbal teach to goal education|BEHAVIORAL: Video based teach to goal education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Non-invasive Neustimulation and Respiratory Rehabilitation
Status: RECRUITING
Conditions: Lung Diseases
Interventions: OTHER: Active non-invasive stimulation and inspiratory muscle training|OTHER: Sham compatorator and inspiratory muscle training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Using Different Spinal Needle Sizes on the Efficacy of the Dural Puncture Epidural Block
Status: ACTIVE_NOT_RECRUITING
Conditions: Dural Puncture Epidural Technique
Interventions: PROCEDURE: Epidural analgesia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: The Nutritional Health for the Elderly Reference Centre Study (The NHERC Study)
Status: COMPLETED
Conditions: Malnutrition
Interventions: DIETARY_SUPPLEMENT: Oral Nutritional Supplement with AN 777|OTHER: Oral Nutritional Supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Effect of Ustekinumab (Stelara®) and Etanercept (Enbrel®) in Participants With Moderate to Severe Psoriasis (MK-0000-206)
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Ustekinumab|DRUG: Etanercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Teriparatide as a Chondroregenerative Therapy in OA
Status: COMPLETED
Conditions: Knee Osteoarthritis|Cartilage Degeneration
Interventions: DRUG: Teriparatide|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A One Year Double-blind Trial to Investigate the Efficacy and Safety of Meloxicam Oral Suspension in Juvenile Rheumatoid Arthritis (JRA/JIA)
Status: COMPLETED
Conditions: Arthritis, Juvenile Rheumatoid
Interventions: DRUG: meloxicam 0.25 mg/kg|DRUG: meloxicam 0.125 mg/kg|DRUG: naproxen 10 mg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Perioperative Treatment of Combined SOX With Apatinib and Camrelizumab for Oesophagogastric Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma
Interventions: DRUG: Apatinib 250mg|DRUG: Camrelizumab|DRUG: S-1, Oxaliplatin|DRUG: Apatinib 500mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Clinical Study to Evaluate the Tolerability and Pharmacokinetics of TQB3811 Tablets in Patients With Advanced Malignant Tumors
Status: UNKNOWN
Conditions: Solid Tumor
Interventions: DRUG: TQB3811
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy the Medigus SRS Endoscopic Stapling System in Gastroesophageal Reflux Disease (GERD)
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease (GERD)
Interventions: DEVICE: Medigus SRS endoscopic stapling system
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gastrointestinal and Health-related Quality of Life in Kidney Transplant Patients Treated With Mycophenolate Mofetil
Status: COMPLETED
Conditions: Maintenance Kidney Transplant
Interventions: DRUG: Enteric-coated Mycophenolate sodium (EC-MPS)|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Bioavailability of Rifampicin in (FDCs) Widely Used in South Africa to Treat Drug-susceptible (TB)
Status: COMPLETED
Conditions: Tuberculosis
Interventions: DRUG: Rimactane|DRUG: Rifafour e-275|DRUG: Rimactazid 150/75
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effect of Pomanox® on Skin Ageing (POMASKIN)
Status: NOT_YET_RECRUITING
Conditions: Skin Ageing
Interventions: DIETARY_SUPPLEMENT: 367 mg Pomanox group|DIETARY_SUPPLEMENT: 700 mg Pomanox group|DIETARY_SUPPLEMENT: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Utility of Radiotherapy in the Management of Haemoptysis Secondary to Aspergillomata and Structural Lung Diseases
Status: UNKNOWN
Conditions: Haemoptysis
Interventions: RADIATION: External beam radiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety of MEDI7836 in Healthy Adults.
Status: COMPLETED
Conditions: Healthy Adults
Interventions: DRUG: Placebo SC|BIOLOGICAL: MEDI7836 Dose 1|BIOLOGICAL: MEDI7836 Dose 2|BIOLOGICAL: MEDI7836 Dose 3|BIOLOGICAL: MEDI7836 Dose 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Lacutamab in Patients With Relapsed/Refractory Peripheral T-cell Lymphoma That Express KIR3DL2
Status: COMPLETED
Conditions: Peripheral T Cell Lymphoma
Interventions: BIOLOGICAL: lacutamab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Barriers to Adherence to Recommended Follow-up in Women With a History of Gestational Diabetes
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: BEHAVIORAL: 2 online nutrition and exercise education classes|BEHAVIORAL: Self monitoring of blood glucose levels
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tahini, Antioxidant Status and Endothelial Function
Status: COMPLETED
Conditions: Oxidative Stress|Endothelial Function|Blood Pressure|Arterial Stiffness|Blood Glucose
Interventions: OTHER: Tahini
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Clinical Investigation of the Safety and Effectiveness of the ABV-1701 Ocular Endotamponade (OE)
Status: SUSPENDED
Conditions: Retinal Detachment
Interventions: DEVICE: ABV-1701|DEVICE: SF6 Gas
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electrical Muscle Stimulation in Congestive Heart Failure
Status: UNKNOWN
Conditions: Congestive Heart Failure|Electric Muscle Stimulation|Severe Decondition|Elderly Person|Exercise Capacity|Activities of Daily Living
Interventions: DEVICE: Electrical muscle devise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Phase I Study With Sorafenib in Addition to Vinflunine in Metastatic Transitional Cell Carcinoma of the Urothelial Tract
Status: COMPLETED
Conditions: Urothelial Carcinoma|Bladder Cancer|Renal Pelvis Cancer|Ureter Cancer|Urethra Cancer
Interventions: DRUG: Vinflunine|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feeding Malnourished Children Different Types of Fatty Acids to Promote Neurocognitive Development
Status: COMPLETED
Conditions: Severe Acute Malnutrition
Interventions: DRUG: Amoxicillin|DIETARY_SUPPLEMENT: HO-RUTF|DIETARY_SUPPLEMENT: D-HO-RUTF|DIETARY_SUPPLEMENT: S-RUTF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Cryotherapy in Pain Control, Function and Quality of Life in Individuals With Knee Osteoarthritis
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: OTHER: Cryotherapy|OTHER: Placebo - Sand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RYMPHYSIA for Alpha1-Proteinase Inhibitor (A1PI) Therapy in Adults With A1PI Deficiency and Chronic Obstructive Pulmonary Disease (COPD)-Emphysema
Status: WITHDRAWN
Conditions: Chronic Obstructive Pulmonary Disease (COPD)|Alpha1-Antitrypsin Deficiency
Interventions: BIOLOGICAL: RYMPHYSIA|BIOLOGICAL: Another Available A1PI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+ Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Estrogen Receptor-positive Breast Cancer
Interventions: DIETARY_SUPPLEMENT: 2-Week Ketogenic Diet|DRUG: Letrozole
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study of Ha44 Gel Administered Topically for the Treatment of Head Lice Infestation
Status: COMPLETED
Conditions: Pediculosis
Interventions: DRUG: Group A - Low-Dose Ha44 0.37% w/w|DRUG: Group B - High Dose Ha44 Gel 0.74% w/w|DRUG: Group C - Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Use of RFT5-dgA to Deplete Alloreactive Cells Prior to Haploidentical Stem Cell Transplantation
Status: COMPLETED
Conditions: Leukemia|Cancer
Interventions: BIOLOGICAL: T-Cell Infusion Dose Level -1|BIOLOGICAL: T-Cell Infusion Dose Level 1|BIOLOGICAL: T-Cell Infusion Dose Level 2|BIOLOGICAL: T-Cell Infusion Dose Level 3|BIOLOGICAL: T-Cell Infusion- Dose Level 4
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Metformin in Patients With T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: Insulin glargine/lixisenatide Fixed Ratio Combination|DRUG: Insulin glargine (HOE901)|DRUG: Lixisenatide (AVE0010)|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Rel Bioavailability, Food Effect and Absolute Bioavailability on the Pharmacokinetics of AZD9833
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: RADIATION: [14C]AZD9833 Solution for Infusion, (NMT 22.8 kBq/5mL)|DRUG: AZD9833 film-coated tablet A Dose 1|DRUG: AZD9833 Oral Solution|DRUG: AZD9833 film-coated tablet B Dose 1|DRUG: AZD9833 film-coated tablet A Dose 2|DRUG: AZD9833 film-coated tablet B Dose 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Glycemic Responses to Nutritional Products (v2.0)
Status: UNKNOWN
Conditions: Glycemic Response
Interventions: DIETARY_SUPPLEMENT: First Reference product|DIETARY_SUPPLEMENT: Second Reference product|DIETARY_SUPPLEMENT: Third Reference product|DIETARY_SUPPLEMENT: First Concept product|DIETARY_SUPPLEMENT: Second Concept product|DIETARY_SUPPLEMENT: Third Concept product
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Efficacy and Safety of SPH4336 in Combination With Endocrine Therapy in Breast Cancer Patients With Brain Metastases.
Status: RECRUITING
Conditions: Breast Cancer Brain Metastases
Interventions: DRUG: SPH4336 Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HRYZ-T101 Injection for HPV18 Positive Solid Tumor
Status: RECRUITING
Conditions: Cervical Cancer|Head and Neck Squamous Cell Carcinoma|Carcinoma of Vagina|Carcinoma of Penis|Anal Cancer|Carcinoma of Vulva
Interventions: BIOLOGICAL: HRYZ-T101 Injection|DRUG: Fludarabine + Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of PERIOGEN in the Treatment of Periodontal Bone Defect
Status: COMPLETED
Conditions: Intrabony Periodontal Defect
Interventions: DRUG: PERIOGEN|DRUG: Beta TCP alone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Thermal Therapy and Exercises on Acute Low Back Pain
Status: COMPLETED
Conditions: Low Back Pain
Interventions: DEVICE: Thermal care|OTHER: Exercises|DEVICE: Sham|BEHAVIORAL: Education for the management of acute low back pain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of 0416 Ointment in the Treatment of Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: 0416|DRUG: Vehicle of 0416 test product|DRUG: tacrolimus ointment 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cholecalciferol in Newly Diagnosed Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia With Vitamin D Deficiency
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Lymphocytic Leukemia|Non-Hodgkin Lymphoma|Untreated Chronic Lymphocytic Leukemia|Vitamin D Deficiency
Interventions: DIETARY_SUPPLEMENT: Cholecalciferol|OTHER: Laboratory Biomarker Analysis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strength Training for Older Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Neoplasm|Osteoporosis, Postmenopausal
Interventions: BEHAVIORAL: Resistance Exercise|BEHAVIORAL: Flexibility Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effects of Elastic Band Resistance Exercise on Muscle Strength and Depression in Hospitalized Elderly.
Status: NOT_YET_RECRUITING
Conditions: Resistance Exercise|Muscle Weakness|Functional Decline
Interventions: DEVICE: Elastic Band
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Single Centre Study to Compare Harmonic Scalpel to Conventional Diathermy in Free Tissue Transfer Breast Reconstruction
Status: WITHDRAWN
Conditions: Breast Reconstruction
Interventions: PROCEDURE: Harmonic Synergy Dissecting Hook (Harmonic Scalpel)|PROCEDURE: Electrocautery Diathermy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning in Difficult-weaning Patients
Status: UNKNOWN
Conditions: Ventilator Weaning
Interventions: PROCEDURE: switching between invasive and noninvasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exploratory Clinical Study of MT-2301
Status: COMPLETED
Conditions: Haemophilus Influenza Type b
Interventions: BIOLOGICAL: Haemophilus b conjugate vaccine diphteria CRM197 protein conjugate)-Low + DPT-IPV|BIOLOGICAL: Haemophilus b conjugate vaccine diphteria CRM197 protein conjugate)-High + DPT-IPV|BIOLOGICAL: Haemophilus influenza type b conjugate vaccine + DPT-IPV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial
Status: NOT_YET_RECRUITING
Conditions: Tobacco Use Disorder|Psychiatric Disorder|Nicotine Dependence
Interventions: DEVICE: Brainsway H4 deep Repetitive Transcranial Magnetic Stimulation (rTMS) coil|DRUG: Nicotine replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of the Effect of a Nurse Navigator Program on High Risk Patients
Status: NOT_YET_RECRUITING
Conditions: Patient Readmission|Arthroplasty, Replacement, Knee|Arthroplasty, Replacement, Hip|Heart Failure|Pulmonary Disease, Chronic Obstructive|Renal Insufficiency|Body Mass Index|Alcoholism
Interventions: OTHER: Nurse Navigator Program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Post-Marketing Surveillance Study to Assess the Safety of Fedratinib in Korean Patients With Myelofibrosis
Status: RECRUITING
Conditions: Primary Myelofibrosis|Post-polycythemia Vera Myelofibrosis|Post-essential Thrombocythemia Myelofibrosis
Interventions: DRUG: Fedratinib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of 5-Azacitidine (Vidaza®) in Patients With Chronic Myelomonocytic Leukemia
Status: COMPLETED
Conditions: Chronic Myelomonocytic Leukemia
Interventions: DRUG: 5-Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Psychotherapy and Pharmacotherapy in the Treatment of Erectile Dysfunction: A Pilot Study
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: BEHAVIORAL: Cognitive Behavioral Psychotherapy|DRUG: Sildenafil Citrate 50Mg Tab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: A Placebo and Active Controlled Study of ONO-6950 Following Allergen Challenge in Patients With Asthma
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: ONO-6950|DRUG: Placebo|DRUG: Montelukast
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Cam2020 M2SR H3N2 Monovalent Influenza Vaccine Alone or With Licensed IIV in Older Adults
Status: COMPLETED
Conditions: Influenza Vaccine
Interventions: BIOLOGICAL: Cam2020 M2SR H3N2 influenza vaccine|BIOLOGICAL: Fluzone HD IIV|OTHER: IN Placebo|OTHER: IM Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Gingival Recessions With Connective Tissue or Concentrated Growth Factor Membrane Using Tunnel Technique
Status: COMPLETED
Conditions: Gingival Recession
Interventions: PROCEDURE: Tunnel technique|PROCEDURE: Connective tissue graft|OTHER: Concentrated growth factor membrane
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: 64N Nutraceutical for the Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings
Status: UNKNOWN
Conditions: Diarrhea|Pneumonia
Interventions: DIETARY_SUPPLEMENT: 64N Nutraceutical|OTHER: No 64N Nutraceutical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: An Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monotherapy Versus MTX in Participants With Moderate to Severe Rheumatoid Arthritis With Inadequate Response to Current Disease-Modifying Antirheumatic Drug (DMARD) Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Tocilizumab|DRUG: MTX|DRUG: Placebo Matched to MTX|DRUG: Placebo Matched to Tocilizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Replicative Stress in Hair Follicle Stem Cells and Pathogeny of Hidradenitis Suppurativa
Status: UNKNOWN
Conditions: Hidradenitis Suppurativa
Interventions: OTHER: Skin biopsy|OTHER: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Comparison Between Different Techniques in Difficult CBD Cannulation
Status: COMPLETED
Conditions: ERCP, Difficult CBD Cannulation
Interventions: PROCEDURE: DGT vs TPS vs Precut and fistulotomy in Difficult CBD cannulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Speed, Agility, and Quickness Training
Status: NOT_YET_RECRUITING
Conditions: Speed|Agility|Quickness|Physical Performance
Interventions: BEHAVIORAL: Speed, Agility, and Quickness (SAQ) Training|BEHAVIORAL: Regular Training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intraseasonal Short-time Up-dosing With Alutard SQ Grasses
Status: COMPLETED
Conditions: Allergy
Interventions: BIOLOGICAL: Allergy vaccination (Alutard SQ)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Timing of TAP Blocks in Bariatric Surgery
Status: NOT_YET_RECRUITING
Conditions: Opioid Use|Pain, Postoperative
Interventions: DRUG: Bupivacaine-epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Cell Based Non Invasive Prenatal Testing as an Alternative to Chorionic Villus Sampling Following Preimplantation Genetic Testing
Status: COMPLETED
Conditions: Prenatal Diagnoses|Preimplantation Genetic Diagnosis
Interventions: PROCEDURE: Cell-based non-invasive prenatal testing
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: To Assess The Patient Preference for Goserelin Microsphere Versus Goserelin Implant in Patients With Prostate Cancer
Status: RECRUITING
Conditions: Prostate Cancer
Interventions: DRUG: Zoladex|DRUG: LY01005
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Mechanisms of Tissue Repair After Muscle Injury and Tendon Strain
Status: COMPLETED
Conditions: Muscle; Injury, Quadriceps (Thigh)|Tendon Strain
Interventions: OTHER: Neuromuscular electrical stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Control of Sinus Node Tachycardia as an Additional Therapy in Patients With Decompensated Heart Failure
Status: UNKNOWN
Conditions: Decompensated Heart Failure
Interventions: DRUG: ivabradine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients With Sickle Cell Disease (SCD)
Status: RECRUITING
Conditions: SCD
Interventions: DIAGNOSTIC_TEST: Non-Invasive Infrared Spectroscopy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Azacitidine and Entinostat Before Chemotherapy in Treating Patients With Advanced Non-small Cell Lung Cancer
Status: TERMINATED
Conditions: Recurrent Non-Small Cell Lung Carcinoma|Stage IIIA Non-Small Cell Lung Cancer|Stage IIIB Non-Small Cell Lung Cancer|Stage IV Non-Small Cell Lung Cancer
Interventions: DRUG: Azacitidine|DRUG: Azacitidine|DRUG: Docetaxel|DRUG: Entinostat|DRUG: Gemcitabine Hydrochloride|DRUG: Irinotecan Hydrochloride|OTHER: Laboratory Biomarker Analysis|DRUG: Pemetrexed Disodium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Individualized Treatment of Hyperphosphatemia in Maintenance Hemodialysis Patients
Status: COMPLETED
Conditions: Maintenance Hemodialysis|Hyperphosphatemia
Interventions: DRUG: Phosphate-binder intervention|DIETARY_SUPPLEMENT: Phosphorus-restricted dietary intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Growth and Safety Study of an Infant Formula for Healthy Term Infants
Status: COMPLETED
Conditions: Infant Development
Interventions: OTHER: BBN|OTHER: Brand
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Comparison of qPCR to IHC and FISH for Detection of ALK Fusion Mutations in FFPE Tissue From NSCLC Patients
Status: COMPLETED
Conditions: Nonsmall Cell Lung Cancer
Interventions: DEVICE: ALK qPCR assay
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Calcichew D3 Preference Study in Participants Eligible for Calcium and Vitamin D Supplementation.
Status: COMPLETED
Conditions: Calcium and Vitamin D Deficiencies
Interventions: DRUG: Calcichew D3|DRUG: Adcal-D3|DRUG: Kalcipos-D
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunity and Safety of Inactivated Enterovirus 71 Vaccine Post-marketing Among Children Aged 6-35 Months in China
Status: COMPLETED
Conditions: Hand, Foot and Mouth Disease
Interventions: BIOLOGICAL: The first batch of inactivated EV-A71 vaccine (vero cell) producted by 40 L reactor|BIOLOGICAL: The second batch of inactivated EV-A71 vaccine (vero cell) producted by 40 L reactor|BIOLOGICAL: The third batch of inactivated EV-A71 vaccine (vero cell) producted by 40 L reactor|BIOLOGICAL: The first batch of inactivated EV-A71 vaccine (vero cell) producted by 150 L reactor|BIOLOGICAL: The second batch of inactivated EV-A71 vaccine (vero cell) producted by 150 L reactor|BIOLOGICAL: The third batch of inactivated EV-A71 vaccine (vero cell) proudected by 150 L reactor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: ATL001 in Patients With Advanced Unresectable or Metastatic NSCLC
Status: RECRUITING
Conditions: Advanced Non Small Cell Lung Cancer
Interventions: BIOLOGICAL: ATL001|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics of Injectable Estradiol and Progesterone Microspheres Suspension
Status: COMPLETED
Conditions: Menopause
Interventions: DRUG: Estradiol + Progesterone|DRUG: Estradiol + Progesterone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I Study to Assess Cardiac and General Safety and Pharmacokinetics of 60 mg MGN1703
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: MGN-Placebo|DRUG: Placebo-MGN
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Three-level Injection Paravertebral Block vs General Anesthesia in Mastectomy
Status: COMPLETED
Conditions: Radical Mastectomy
Interventions: PROCEDURE: paravertebral block|DRUG: fentanyl, propofol, atracurium|DRUG: lidocaine , adrenaline, ketamine bolus, midazolam|DEVICE: catheter with 3-level-injection|DRUG: sevoflurane and 50% oxygen in air
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study
Status: RECRUITING
Conditions: Cigarette Smoking Behavior
Interventions: OTHER: Access to all varieties of on! 4mg nicotine pouches (Berry, Citrus, Cinnamon, Wintergreen, Mint, Coffee, and Original)|OTHER: Access to Original on! 4mg nicotine pouches|OTHER: Non-Flavored then complete flavor on! nicotine pouches
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: I5NP for Prophylaxis of Delayed Graft Function in Kidney Transplantation
Status: COMPLETED
Conditions: Delayed Graft Function|Other Complication of Kidney Transplant
Interventions: DRUG: I5NP|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treating People With Post-Traumatic Stress Disorder With Cognitive Behavioral Therapy for Insomnia
Status: COMPLETED
Conditions: Post-Traumatic Stress Disorder
Interventions: OTHER: Cognitive Behavioral Treatment for Insomnia (CBT-I)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Healthy Children 2021 Study in Childcare Centers
Status: COMPLETED
Conditions: Family Health|Child Health|Sleep|Child|Executive Function|Pediatric Obesity|Dietary Habits
Interventions: BEHAVIORAL: The education and training of early childhood educators and their intervention on children
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Relationship Between Sleep EEG, Intraoperative EEG and Postoperative Cognitive Dysfunction
Status: RECRUITING
Conditions: Postoperative Cognitive Dysfunction
Interventions: DEVICE: Sleep EEG recording using a DREEM® headband|OTHER: Montreal Cognitive Assessment (MoCA)|DEVICE: Intraoperative EEG recording using a Sedline® monitoring
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Dose-Response Study of Ibalizumab (Monoclonal Antibody) Plus Optimized Background Regimen in Patients With HIV-1
Status: COMPLETED
Conditions: HIV
Interventions: DRUG: Ibalizumab|DRUG: Ibalizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Diazoxide Choline to Treat Hypertriglyceridemia
Status: COMPLETED
Conditions: Hypertriglyceridemia|Dyslipidemia
Interventions: DRUG: Diazoxide Choline Controlled-Release Tablet|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gemcitabine in Newly-Diagnosed Diffuse Midline Glioma
Status: WITHDRAWN
Conditions: Glial Tumor of Brain|Diffuse Intrinsic Pontine Glioma|Glioma
Interventions: DRUG: Gemcitabine|PROCEDURE: Tumor biopsy and blood draw
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Impact of Humeral Component Version on Outcomes Following RTSA
Status: COMPLETED
Conditions: Rotator Cuff Tear Arthropathy
Interventions: DEVICE: 0 degrees humeral component version|DEVICE: 30 degrees humeral component retroversion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Intravenous Remifentanil Patient-controlled Analgesia (PCA) and Epidural Patient Controlled Epidural Analgesia (PCEA) for Labor Analgesia
Status: COMPLETED
Conditions: Labor|Pain
Interventions: DRUG: Bupivacaine epidural|DRUG: Remifentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: UPCC 36315 A Phase II Study Of Everolimus (RAD001) And Lenvatinib (E7080) In Patients With Metastatic Differentiated Thyroid Cancer Who Have Progressed on Lenvatinib Alone
Status: SUSPENDED
Conditions: Thyroid Cancer
Interventions: DRUG: Lenvatinib|DRUG: Everolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy With Autologous Tumor Lysate-Loaded Dendritic Cells In Patients With Newly Diagnosed Glioblastoma Multiforme
Status: UNKNOWN
Conditions: Glioblastoma
Interventions: BIOLOGICAL: Dendritic Cells Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relative Bioavailability Study of Two New Dolutegravir/Abacavir/Lamivudine Fixed Dose Combination Tablets
Status: COMPLETED
Conditions: Healthy Subjects|Infection, Human Immunodeficiency Virus
Interventions: DRUG: Dolutegravir 50 mg/abacavir 600 mg/lamivudine 300 mg|DRUG: Dolutegravir 50 mg|DRUG: abacavir 600 mg/lamivudine 300 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Treatment of RP and LCA by Primary RPE Transplantation
Status: UNKNOWN
Conditions: Leber Congenital Amaurosis, Retinitis Pigmentosa
Interventions: BIOLOGICAL: Human primary Retinal Pigment Epithelial (HuRPE) cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Tube 1st Technique for Easy Fiberoptic Intubation
Status: COMPLETED
Conditions: Difficult Intubation
Interventions: OTHER: fiberoptic intubation classic technique|OTHER: fiberoptic intubation tube 1st technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Trial of SARS-CoV-2 mRNA Vaccine in China
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Interventions: BIOLOGICAL: Low-dose of LVRNA009|BIOLOGICAL: Middle-dose of LVRNA009|BIOLOGICAL: High-dose of LVRNA009|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Treat Early and Broad: Thermotherapy of Buruli Ulcer Integrated Into WHO-recommended Wound Management in West Africa
Status: RECRUITING
Conditions: Skin Ulcer|Buruli Ulcer|Nontuberculous Mycobacteria
Interventions: OTHER: thermotherapy (application of heat): This part of the trial is on hold due to the Covid19-pandemia
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Ramucirumab Plus TAS-102 in Patients With Advanced or Metastatic Gastric Adenocarcinoma or the Gastroesophageal Junction
Status: COMPLETED
Conditions: Gastric Adenocarcinoma|Metastatic Adenocarcinoma of the Gastroesophageal Junction
Interventions: DRUG: Ramucirumab|DRUG: TAS 102
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Influence of Prematurity and Its Respiratory Sequel on Exercise Testing in Childhood
Status: COMPLETED
Conditions: The Peak Oxygen Consumption (VO2max) Was Measured and Served as the Primary Endpoint of the Study
Interventions: DIAGNOSTIC_TEST: Cardio-Pulmonary-Exercise-Testing (CPET)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Effects of Nutritional Fat on the Growth of Intestinal E. Coli
Status: UNKNOWN
Conditions: Escherichia Coli Infections
Interventions: DRUG: "Mutaflor Suspension" (E. coli Nissle 1917)|OTHER: Blood samples|OTHER: Stool samples|OTHER: Clinical information
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexamethasone vs Bicarbonate to Intracuff Lignocaine 2% in General Anaesthesia
Status: COMPLETED
Conditions: Anesthesia|Anesthesia; Adverse Effect|Anesthesia Intubation Complication
Interventions: DRUG: lignocaine+bicarbonate|DRUG: lignocaine+dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Rollover Study for Subjects Participating in the Control Arm of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Whose Plasma Hepatitis C Virus (HCV) Ribonucleic Acid (RNA) Levels Did Not Respond to Therapy
Status: COMPLETED
Conditions: Hepatitis C
Interventions: DRUG: Telaprevir|DRUG: Ribavirin|DRUG: Pegylated interferon alfa 2a
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decision Aid to Assist Low-Risk Nulliparous Women Considering Induction of Labor At 39 Weeks
Status: TERMINATED
Conditions: Pregnancy Related|Elective Induction
Interventions: BEHAVIORAL: Shared decision-making with a Decision-aid|BEHAVIORAL: routine shared decision-making
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Percutaneous Transhepatic Cholangiography (PTHC) in Acute Cholecystitis and Clinical Outcomes
Status: WITHDRAWN
Conditions: Cholecystitis, Acute|Elderly Infection|Drain Abscess
Interventions: PROCEDURE: Percutaneous cholecystostomy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lactobacillus Plantarum P8 for Its Brain Health Promotion Potential
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DIETARY_SUPPLEMENT: Lactobacillus plantarum P8|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Magnetic Therapy Versus Exercise Therapy in Old Patients With Chronic Mechanical Neck Pain
Status: COMPLETED
Conditions: Chronic Mechanical Neck Pain
Interventions: DEVICE: Electromagnetic Field therapy with an exercise program|OTHER: exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Examination of Pregabalin Access for Treatment of Indicated Pain Disorders: the ExPAND Study
Status: TERMINATED
Conditions: Fibromyalgia|Painful Diabetic Peripheral Neuropathy
Interventions: OTHER: prior authorization|OTHER: no prior authorization|OTHER: prior authorization|OTHER: no prior authorization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an Intrathecal Drug Delivery Device in Pediatric Patients With Hunter Syndrome Who Have Central Nervous System Involvement and Are Receiving Treatment With Elaprase®
Status: COMPLETED
Conditions: Hunter Syndrome
Interventions: OTHER: Control|DRUG: Idursulfase IT (1 mg)|DRUG: Idursulfase IT (10 mg)|DRUG: Idursulfase IT (30 mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures
Status: COMPLETED
Conditions: Pain, Postoperative|Femur Fracture
Interventions: DRUG: Ropivacaine|DRUG: Epinephrine|DRUG: Morphine|DRUG: 0.9% sodium chloride solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Status: TERMINATED
Conditions: Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia
Interventions: DRUG: entinostat|DRUG: imatinib mesylate|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|GENETIC: western blotting|OTHER: immunohistochemistry staining method|OTHER: flow cytometry|GENETIC: polymerase chain reaction|OTHER: high performance liquid chromatography|OTHER: mass spectrometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors
Status: COMPLETED
Conditions: Advanced Breast Cancer|HER2/Neu Negative|Triple-Negative Breast Cancer
Interventions: DRUG: Talazoparib Tosylate
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Analysis of the Pathogenesis of Itch in Response to Apremilast Therapy in Psoriasis Patients
Status: WITHDRAWN
Conditions: Moderate to Severe Plaque Psoriasis
Interventions: DRUG: Apremilast;Apremilast;Apremilast 10 MG; 20 MG; 30 MG Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Psychoeducation of Adult Siblings of ASD People (Autism Spectrum Disorder).
Status: ACTIVE_NOT_RECRUITING
Conditions: Autism Spectrum Disorder|Sibling Relations
Interventions: OTHER: Cygnet program for ASD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Physicians' Health Study II
Status: COMPLETED
Conditions: Cancer|Prostate Cancer|Colorectal Cancer|Cardiovascular Disease|Eye Disease|Cognitive Decline
Interventions: DIETARY_SUPPLEMENT: Vitamin E|DIETARY_SUPPLEMENT: Vitamin C|DIETARY_SUPPLEMENT: Multivitamin|DIETARY_SUPPLEMENT: Beta-carotene
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION