pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Nutritional Intervention-induced Weight Loss During the Oncological Treatment of Obesity-related Breast Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Obesity|Weight Change, Body|Epigenetic Disorder
Interventions: OTHER: Very low calorie ketogenic diet (VLCKD)|BEHAVIORAL: Group educational intervention program (IGOBE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Mannitol on Recovery Pattern After Orthognathic Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Orthognathic Surgery
Interventions: DRUG: Mannitol|DRUG: Ringer's Lactate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy Study of Switching Stabilized Schizophrenic Patients From Conventional to Atypical Antipsychotic Treatment
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: olanzapine|DRUG: haloperidol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: A Low ChloridE hyperTonic Solution for Brain Edema
Status: COMPLETED
Conditions: Subarachnoid Hemorrhage|Acute Kidney Injury
Interventions: DRUG: Sodium chloride /sodium acetate (16.4%)|DRUG: Sodium chloride (23.4%)|DRUG: PlasmaLyte
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Observational Study to Evaluate Clinical Performance and Safety in Total Knee Arthroplasty
Status: ACTIVE_NOT_RECRUITING
Conditions: Total Knee Arthroplasty|Knee Disease|Total Knee Replacement|Osteo Arthritis Knee
Interventions: DEVICE: patient with knee arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Azacitidine and Oxaliplatin In Treating Patients With Advanced Cancers Relapsed or Refractory to Any Platinum Therapy
Status: COMPLETED
Conditions: Adult Solid Neoplasm|Hematopoietic and Lymphoid Cell Neoplasm
Interventions: DRUG: Azacitidine|OTHER: Laboratory Biomarker Analysis|DRUG: Oxaliplatin|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: IUGR, Respiratory Muscle Function, and Exercise Capacity in Childhood
Status: UNKNOWN
Conditions: Intrauterine Growth Restriction|Cardiopulmonary Disease
Interventions: DIAGNOSTIC_TEST: Cardiopulmonary Exercise Testing|DIAGNOSTIC_TEST: Respiratory Muscle Strength and Endurance
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Randomized Study Evaluating the Efficacy of Low Intensity Transcranial Electrical Stimulation (Tdcs) for the Relief of Dyspnea
Status: UNKNOWN
Conditions: Dyspnea|Mechanical Ventilation Complication
Interventions: DEVICE: Placebo|DEVICE: Anodal|DEVICE: Cathodal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety/Efficacy of Tigan® to Control Nausea/Vomiting Experienced During Apokyn® Initiation and Treatment
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: DRUG: Tigan®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Base Curves of Bandage Contact Lenses and Their Effects on Post Trans-PRK Vision and Pain
Status: RECRUITING
Conditions: Myopia
Interventions: PROCEDURE: single-step Trans-PRK|BEHAVIORAL: Placing a bandage contact lens on the cornea, with an 8.4-mm base curve in right eye and one with an 8.8-mm base curve in the left eye.|BEHAVIORAL: Placing a bandage contact lens on the cornea,A contact lens placed on the cornea, with an 8.8-mm base curve in right eye and one with an 8.4-mm base curve in the left eye.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Baricitinib for the Treatment of Moderate to Severe Rheumatoid Arthritis
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: Baricitinib 4 MG Oral Tablet|DRUG: Baricitinib 2 MG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Novel Dual-Task Exercise Program for Balance, Mobility and Cognition in Community Dwelling Older Adults
Status: COMPLETED
Conditions: Aging
Interventions: BEHAVIORAL: Dual task treadmill walking exercise program|BEHAVIORAL: Dual task recumbent cycling exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Thyroid Disease in Pregnancy: Case Finding Versus Universal Screening
Status: COMPLETED
Conditions: Thyroid Disease|Pregnancy
Interventions: DRUG: Levothyroxine, Propylthiouracile
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate TAlazoparib, Radiotherapy and Atezolizumab in gBRCA 1/2 Negative Patients With PD-L1+ Metastatic Triple Negative Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Triple Negative Breast Cancer
Interventions: DRUG: Talazoparib|DRUG: Atezolizumab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Absorption, Metabolism and Excretion of [14C]ASP8273 in Subjects With Solid Tumors
Status: WITHDRAWN
Conditions: Epidermal Growth Factor Receptor (EGFR) Mutations|Solid Tumors
Interventions: DRUG: radio-labeled naquotinib|DRUG: naquotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 6(S)-5-MTHF Among Selective Serotonin Reuptake Inhibitor-Resistant Outpatients With Major Depressive Disorder
Status: COMPLETED
Conditions: Depression
Interventions: OTHER: 6(S)-5-MTHF(Deplin)|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support
Status: TERMINATED
Conditions: Critical Illness
Interventions: DRUG: vasopressor|DRUG: fluid bolus|DEVICE: oesophagus doppler (CardioQ)|DRUG: Normal Saline|DEVICE: arterial cannulation|DEVICE: intravenous peripheral line insertion (17 gauge)|DRUG: Elo-Mel Isoton (balanced acetat-based infusate)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Flash Glucose Monitoring in Reduction of Hypoglycaemia in Diabetic Patients With Chronic Kidney Disease
Status: UNKNOWN
Conditions: Diabetes With Diabetic Chronic Kidney Disease (Diagnosis)
Interventions: DEVICE: Abbott FreeStyle Libre|DEVICE: Patient Own SMBG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: MR7T-Healthy-PTX : Brain Exploration in Magnetic Resonance Imaging in Parallel Transmission Mode (pTX) at 7 Tesla
Status: UNKNOWN
Conditions: MRI|PTX|BRAIN|7 TESLA
Interventions: OTHER: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Iron Aid IPS on Performance, Fatigue and Iron Levels During 12 Weeks of Supplementation and Aerobic Training
Status: TERMINATED
Conditions: Iron-deficiency
Interventions: DIETARY_SUPPLEMENT: Iron Aid IPS (Iron Protein Succinylate)|OTHER: Sugar Pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Diagnostic Value of Compression Ultrasound to Detect Acute Compartment Syndrome After Lower Limb Revascularisation
Status: UNKNOWN
Conditions: Compartment Syndrome of Leg
Interventions: DIAGNOSTIC_TEST: Compression ultrasound examination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Extension Study for Participants in LIQ861 Trials to Evaluate the Long-term Safety of Dry Powder Inhalation of Treprostinil
Status: UNKNOWN
Conditions: Primary Pulmonary Hypertension
Interventions: DRUG: LIQ861 Inhaled Treprostinil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)
Status: COMPLETED
Conditions: Restless Legs Syndrome
Interventions: DEVICE: NTX100 Neuromodulation System - Active|DEVICE: NTX100 Neuromodulation System - Sham|DEVICE: NTX100 Neuromodulation System - Open-Label
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Supragingival Control Versus Supra- and Subgingival Control in the Periodontal Health During the Maintenance
Status: UNKNOWN
Conditions: Periodontitis
Interventions: PROCEDURE: Group 1 - Supragingival biofilm control|PROCEDURE: Group 2 - Supra- and subgingival biofilm control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Riluzole on CNS Glutamate and Fatigue in Breast Cancer Survivors With High Inflammation
Status: COMPLETED
Conditions: Inflammation|Fatigue
Interventions: DRUG: Riluzole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Access to Genetic Testing in Underserved Patients With Cancer
Status: NOT_YET_RECRUITING
Conditions: Breast Carcinoma|Male Breast Carcinoma|Malignant Solid Neoplasm|Metastatic Prostate Carcinoma|Ovarian Carcinoma|Pancreatic Exocrine Neoplasm|Stage IVB Prostate Cancer American Joint Committee on Cancer v8|Triple-Negative Breast Carcinoma
Interventions: OTHER: Best Practice|OTHER: Educational Intervention|OTHER: Electronic Health Record Review|OTHER: Genetic Counseling|OTHER: Interview|OTHER: Survey Administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: From Prevention to Community Integration: IPCST for Severe Mental Illness in Chinese Communities (Hong Kong and Beijing)
Status: UNKNOWN
Conditions: Psychosis
Interventions: BEHAVIORAL: IPCST|BEHAVIORAL: E.A.S.Y
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: IVIG - West Nile Encephalitis: Safety and Efficacy
Status: COMPLETED
Conditions: West Nile Virus
Interventions: DRUG: Omr-lgG-am|DRUG: Polygam® S/D|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 3b Study to Evaluate Skeletal Response to Eliglustat in Adult Patients Who Completed Phase 2 or Phase 3 Studies
Status: COMPLETED
Conditions: Gaucher Disease
Interventions: DRUG: Eliglustat, GZ385660
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extrahepatic Insulin Resistance in Chronic Hepatitis C
Status: COMPLETED
Conditions: Insulin Resistance
Interventions: DRUG: Ledipasvir 90 mg/Sofosbuvir 400 mg|DRUG: Ribavirin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Paediatric Ards Neuromuscular Blockade Study
Status: SUSPENDED
Conditions: ARDS
Interventions: DRUG: Neuromuscular Blocking Agents|DRUG: Isotonic saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Aerobic Exercise on Diurnal Cortisol Pattern in Premenstrual Syndrome
Status: COMPLETED
Conditions: Premenstrual Syndrome
Interventions: OTHER: Relaxation training|OTHER: An aerobic exercise program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DAPPAR AF Dabigatran for Peri Procedural Anticoagulation During Radiofrequency Ablation of Atrial Fibrillation
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DRUG: dabigatran
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study of BDB-001 Injection in Patients With Moderate to Severe Hidradenitis Suppurativa (HS)
Status: COMPLETED
Conditions: Hidradenitis Suppurativa
Interventions: DRUG: BDB-001 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Biomarkers Associated With Postoperative Cognitive Dysfunction
Status: RECRUITING
Conditions: Delirium|Postoperative Cognitive Dysfunction|Cognitive Decline|Cognitive Impairment
Interventions: PROCEDURE: Intraoperative electroencephalography recording|PROCEDURE: Neurofilament light chain measurement|PROCEDURE: Tau protein measurement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis
Status: COMPLETED
Conditions: Ketoacidosis|Diabetes Mellitus Type 1
Interventions: BIOLOGICAL: LPS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open-label Study of the Efficacy of Intranasal Oxytocin in Schizophrenia
Status: TERMINATED
Conditions: Schizophrenia
Interventions: DRUG: Oxytocin: 24IU - 168 IU|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
Status: RECRUITING
Conditions: Hypertension|Left Ventricular Hypertrophy
Interventions: DRUG: Eplerenone|DRUG: Chlorthalidone|DRUG: Potassium
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of AbGn-168 in Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: AbGn168 intravenous infusion|DRUG: AbGn168 intravenous infusion|DRUG: AbGn168 intravenous infusion|DRUG: AbGn168 intravenous infusion|DRUG: AbGn168 intravenous infusion|DRUG: AbGn168 intravenous infusion|DRUG: AbGn168 intravenous infusion|DRUG: AbGn168 subcutaneous injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Santeon-CAP; Dexamethasone in Community-acquired Pneumonia
Status: TERMINATED
Conditions: Community-acquired Pneumonia
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Study of Azacitidine Combined With Ruxolitinib in the Treatment of Higher-risk MDS/MPN
Status: RECRUITING
Conditions: MDS/MPN
Interventions: DRUG: Azacitidine (AZA) with Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Challenge Study of Live Oral Cholera Vaccine Candidate,PXVX0200, to Prevent Cholera
Status: COMPLETED
Conditions: Cholera
Interventions: BIOLOGICAL: PXVX0200|BIOLOGICAL: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Dose Escalation and Expansion Study of GSK3359609 in Participants With Selected Advanced Solid Tumors (INDUCE-1)
Status: COMPLETED
Conditions: Neoplasms
Interventions: DRUG: feladilimab (GSK3359609)|DRUG: GSK3174998|DRUG: Pembrolizumab|DRUG: Docetaxel|DRUG: Pemetrexed|DRUG: Paclitaxel plus Carboplatin|DRUG: Gemcitabine plus Carboplatin|DRUG: Fluorouracil (5-FU) plus carboplatin or cisplatin|DRUG: Dostarlimab|DRUG: Cobolimab|DRUG: Bintrafusp alfa
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Zalutumumab in Combination With Radiotherapy in Head and Neck Cancer Patients Ineligible for Platinum Based Chemotherapy
Status: TERMINATED
Conditions: Head and Neck Cancer|Squamous Cell Carcinoma
Interventions: DRUG: Zalutumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Electro-acupuncture for Menopausal Transition Symptoms
Status: COMPLETED
Conditions: Menopause
Interventions: DEVICE: Eelectro-acupuncture|DEVICE: Sham Eelectro-acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIOSURE™ RG Knee Safety & Performance Study
Status: COMPLETED
Conditions: ACL Repair|Posterior Cruciate Ligament (PCL) Repair|Medial Collateral Ligament (MCL)|Lateral Collateral Ligament (LCL)|Posterior Oblique Ligament (POL)|Patellar Realignment and Tendon Repairs|Vastus Medialis Obliquus Advancement|Iliotibial Band Tenodesis|Extra-capsular Repairs|Knee Repair
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability, Immunogenicity, and Pharmacodynamics (PD) of GSK2800528 in Healthy Subjects.
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: GSK2800528, solution for injection|DRUG: Placebo (0.9% w/v Sodium Chloride), solution for injection|DRUG: Adalimumab, solution for injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant/Adjuvant Tislelizumab Combined With Anlotinib and Platinum Doublet Chemotherapy With Resectable NSCLC
Status: NOT_YET_RECRUITING
Conditions: Non-Small Cell Lung Cancer|Anti Angiogenesis
Interventions: DRUG: Immunochemotherapy combined with antiangiogenic|DRUG: Immunochemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate the Abuse Potential of ACT-541468 in Healthy Recreational Drug Users
Status: COMPLETED
Conditions: Healthy Recreational Drug Users
Interventions: DRUG: ACT-541468|DRUG: Suvorexant|DRUG: Zolpidem|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Invasive Pulmonary Aspergillosis by Direct Lung Tissue Aspergillus Galactomannan Antigen Detection From Aspirate by Ultrasound-guided Fine Needle Aspiration
Status: UNKNOWN
Conditions: Immunocompromised
Interventions: PROCEDURE: Lung aspiration
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Lenalidomide and Ofatumumab in Treating Participants With Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia|Fatigue|Fever|Hypogammaglobulinemia|Lymphadenopathy|Lymphocytosis|Night Sweats|Paraproteinemia|Small Lymphocytic Lymphoma|Thrombocytopenia
Interventions: DRUG: Lenalidomide|BIOLOGICAL: Ofatumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effects of Spinal Anesthesia on ED50 and BIS50 of Etomidate for the Loss of Consciousness
Status: COMPLETED
Conditions: Dose-Response Relationship, Drug
Interventions: DRUG: spinal anesthesia|OTHER: etomidate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Evaluating the Effect of Bathing Additives in Atopic Dermatitis
Status: TERMINATED
Conditions: Atopic Dermatitis|Eczema
Interventions: OTHER: Dilute vinegar (acetic acid)|OTHER: Dilute bleach
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Ischemia Related Changes in Esophageal Electrocardiography
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: PROCEDURE: Measurement of coronary collateral flow index|PROCEDURE: Measurement of coronary collateral flow index|PROCEDURE: Measurement of coronary collateral flow index|PROCEDURE: Measurement of coronary collateral flow index
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Cadonilimab Combination With Chemotherapy With or Without AK117 in Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Status: RECRUITING
Conditions: Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Interventions: DRUG: Cadonilimab|DRUG: AK117|DRUG: Oxaliplatin|DRUG: Tegafur-gimeracil-oteracil potassium|DRUG: Docetaxel|DRUG: 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
Status: COMPLETED
Conditions: Migraine Without Aura
Interventions: DRUG: Sildenafil|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Intratumoral Microdosing of TAK-981 in Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: TAK-981|BIOLOGICAL: Cetuximab|BIOLOGICAL: Avelumab|COMBINATION_PRODUCT: TAK-981 + Cetuximab|COMBINATION_PRODUCT: TAK-981 + Avelumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Interleukin-2 Following 4SCAR19/22 T Cells Targeting Refractory and/or Recurrent B Cell Malignancies
Status: WITHDRAWN
Conditions: B-Cell Leukemia|B-Cell Lymphoma
Interventions: BIOLOGICAL: 4SCAR19/22 T cells|DRUG: Interleukin-2
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Study for Palmar Hyperhydrosis
Status: COMPLETED
Conditions: Palmar Hyperhidrosis|Hyperhidrosis|Sweat Gland Diseases|Skin Diseases
Interventions: DRUG: Glycopyrronium 2.4 % Medicated Cloth
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Chemotherapy With Methotrexate, Vinblastine, Adriamycin and Cisplatin (M-VAC) Plus Avastin in Patients With Urothelial Cancer
Status: COMPLETED
Conditions: Bladder Cancer
Interventions: DRUG: Avastin|DRUG: Cisplatin|DRUG: Doxorubicin|DRUG: Methotrexate|DRUG: Vinblastine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses
Status: RECRUITING
Conditions: Presbyopia|Astigmatism
Interventions: DEVICE: Lehfilcon A multifocal for astigmatism contact lenses|DEVICE: Samfilcon A multifocal for astigmatism contact lenses|DEVICE: CLEAR CARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of Vandetanib
Status: COMPLETED
Conditions: Medullary Thyroid Cancer
Interventions: DRUG: vandetanib|DRUG: omeprazole|DRUG: ranitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: An Efficacy And Safety Study Evaluating Tofacitinib With And Without Methotrexate Compared To Adalimumab With Methotrexate
Status: COMPLETED
Conditions: Rhematoid Arthritis
Interventions: DRUG: Tofacitinib with methotrexate|DRUG: Tofacitinib without methotrexate|BIOLOGICAL: Adalimumab with methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of AZD5363 Plus Paclitaxel /AZD2014 Plus Paclitaxel in Biomarker Negative (PIK3CA/MEK/RAS/TP53/MET) Gastric Adenocarcinoma Patients as Second-line Chemotherapy
Status: TERMINATED
Conditions: Advanced Gastric Adenocarcinoma
Interventions: DRUG: AZD5363|DRUG: paclitaxel|DRUG: AZD2014|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
Status: UNKNOWN
Conditions: Microbial Colonization|Periodontal Diseases|Periodontal Inflammation
Interventions: PROCEDURE: One-Stage Full Mouth Debridement|DRUG: Amoxicillin 500mg|DRUG: Metronidazole 400mg|DRUG: Amoxicillin Placebo|DRUG: Metronidazole Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mindfulness and Yoga for Pain With Interstitial Cystitis Evaluation
Status: COMPLETED
Conditions: Interstitial Cystitis
Interventions: BEHAVIORAL: Treatment|OTHER: Usual Cares
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Anal Fissure Chronic|Anal Fissure
Interventions: DRUG: Propionibacterium Acnes|DRUG: glyceryl trinitrate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Prospective Radiostereometric Analysis and Clinical Evaluation of the Zimmer® Continuum® Acetabular Cup With Vitamin E Stabilized Polyethylene
Status: UNKNOWN
Conditions: Radiostereometric Analysis|Vitamin E Liner|Zimmer® Continuum® Acetabular Cup
Interventions: RADIATION: RSA images
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Pleurectomy/Decortication Followed by Intrathoracic/Intraperitoneal Heated Cisplatin for Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Pleural Mesothelioma|Malignant Pleural Mesothelioma
Interventions: DRUG: Cisplatin|DRUG: Sodium Thiosulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Training Intervention in Heart Failure and Frail Elderly Population
Status: UNKNOWN
Conditions: Physical Activity
Interventions: OTHER: Multicomponent training intervention.|OTHER: Nutrition intervention|OTHER: Cognitive intervention|OTHER: D-vitamin intervention|OTHER: Occupational intervention|OTHER: Heart failure follow up.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of NNC109-0012 in Subjects With Active Rheumatoid Arthritis
Status: COMPLETED
Conditions: Inflammation|Rheumatoid Arthritis
Interventions: DRUG: NNC109-0012|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Changes in Pain, Spasticity, and Quality of Life After Use of Counterstrain Treatment in Individuals With SCI
Status: COMPLETED
Conditions: Pain|Spasticity, Muscle|Quality of Life
Interventions: OTHER: Counterstrain manual manipulative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of CMAB807 Post-change in Manufacturing Site and Prolia in Healthy Volunteers
Status: RECRUITING
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Post-change CMAB807|BIOLOGICAL: Prolia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: varenicline|DEVICE: transdermal nicotine patch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: To Demonstrate the Relative Bioavailability of Cefzil 500 mg Cefprozil Tablets Under Fed Conditions
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Cefprozil 500 mg Tablets (Sandoz, GmbH)|DRUG: Cefzil (Cefprozil) 500 mg Tablets (Bristol-Myers Squibb, USA)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Odalasvir and AL-335 Alone and in Combination With Simeprevir in Participants With Moderately Impaired Hepatic Function
Status: WITHDRAWN
Conditions: Hepatic Impairment
Interventions: DRUG: AL-335 800 mg|DRUG: ODV 25 mg|DRUG: SMV 75 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Performance and Safety of the PHENIX LIBERTY, a Medical Device for Electrostimulation and Biofeedback, in the Treatment of Pelvic Static Disorders in Women With Urinary Incontinence.
Status: RECRUITING
Conditions: Urinary Incontinence|Pelvic Floor Disorders
Interventions: DEVICE: Electrical stimulation and biofeedback with the medical device Phenix Liberty
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Jing-Si-Herbal-Tea Accelerates SARS-Cov-2 Load Reduction Among COVID-19 Patients
Status: UNKNOWN
Conditions: Coronavirus
Interventions: DRUG: Jing-Si-Herbal-Tea
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 2nd Pivotal Study rPhleum - Adults and Adolescents With Rhinoconjunctivitis +/-Controlled Asthma
Status: COMPLETED
Conditions: Rhinoconjunctivitis|Allergic Asthma
Interventions: DRUG: Grass pollen specific immunotherapy|DRUG: Placabo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Adherence to a Physical Activity Advice
Status: COMPLETED
Conditions: Patient Adherence
Interventions: BEHAVIORAL: social support|BEHAVIORAL: treatment of illness perceptions|DEVICE: Activ8|OTHER: activity advice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne
Status: COMPLETED
Conditions: Acne Vulgaris
Interventions: DRUG: Adapalene Gel, 0.1%|DRUG: Tazarotene Cream, 0.1%|DRUG: Adapalene Gel, 0.1% + Tazarotene Cream, 0.1%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Regional Anesthesia for Totally Awake Upper Limb Surgery in PEDiatric Population
Status: COMPLETED
Conditions: Surgery|Anesthesia, Local|Pediatric ALL
Interventions: DRUG: local anaesthetic injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Stay Healthy In Nature Everyday: Family Nature Outings in a Low Income Population
Status: COMPLETED
Conditions: Stress, Psychological|Social Isolation|Physical Activity
Interventions: BEHAVIORAL: Family outings|BEHAVIORAL: Park prescription|DEVICE: Pedometry|BEHAVIORAL: Case Management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Study of Humanized BCMA-targeted CAR-T Cells Therapy for Refractory/Relapsed Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapse Multiple Myeloma|Refractory Multiple Myeloma
Interventions: DRUG: BCMA Targeted CAR T-cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Scripps Digital Diabetes: Cloud-Based Continuous Glucose Monitoring (CB CGM)
Status: TERMINATED
Conditions: Diabetes Mellitus, Type 2
Interventions: DEVICE: Cloud-Based Continuous Glucose Monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Herceptin (Trastuzumab)and Biomarkers in Patients With HER2-Positive Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Standard taxane therapy|DRUG: capecitabine [Xeloda]|DRUG: trastuzumab [Herceptin]
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Visual Performance Following Implantation of Presbyopia Correcting IOLs
Status: COMPLETED
Conditions: Loss of Visual Contrast Sensitivity|Near Vision|Visual Impairment
Interventions: PROCEDURE: phacoemulsification with implantation of presbyopia correcting IOL
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Efficacy Between Letrozole + Ribociclib and Fulvestrant + Letrozole + Ribociclib in Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer
Status: RECRUITING
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Fulvestrant plus AI plus ribociclib|DRUG: AI plus ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ACL Reconstruction With a New Generation of LARS Artificial Ligament
Status: ACTIVE_NOT_RECRUITING
Conditions: ACL Injury
Interventions: DEVICE: Implantation of LARS artificial grafted ligament to treat ACL injury|DEVICE: Implantation of LARS artificial non-grafted ligament to treat ACL injury
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-Guided Serratus Anterior Plane Block for Additional Pain Relief After Lung Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Thoracic Surgery
Interventions: PROCEDURE: Sham serratus anterior plane block|PROCEDURE: Serratus anterior plane block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036)
Status: COMPLETED
Conditions: Sleep Apnea
Interventions: DRUG: Suvorexant|DRUG: Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Enamel Matrix Derivative as an Adjunct to Minimally Invasive Non-surgical Treatment of Intrabony Defects.
Status: COMPLETED
Conditions: Periodontal Diseases
Interventions: PROCEDURE: MINST|PROCEDURE: MINST with EMD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cladribine Venetoclax in Monocytic AML
Status: RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Cladribine|DRUG: Venetoclax|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinico-functional Evaluation of GERD: Comparative Study of Vertical Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass
Status: COMPLETED
Conditions: Gastroesophageal Reflux Disease|Morbid Obesity
Interventions: PROCEDURE: Roux-en-Y Gastric Bypass|PROCEDURE: Vertical Sleeve Gastrectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Estimation Of Effect Of Rifampin On Pharmacokinetics Of Crizotinib In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: crizotinib|DRUG: rifampin|DRUG: crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Prospective Phase II Study of Rabbit Antithymocyte Globulin (ATG, Thymoglobuline®, Genzyme) With Ciclosporin for Patients With Acquired Aplastic Anaemia
Status: COMPLETED
Conditions: Acquired Aplastic Anaemia
Interventions: DRUG: Rabbit ATG, Thymoglobuline (Genzyme)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Proof-of-Concept Study of Minocycline in Autism
Status: COMPLETED
Conditions: Autism Spectrum Disorder|Autism
Interventions: DRUG: Minocycline|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EMBRACE: Exercising Together
Status: RECRUITING
Conditions: Breast Carcinoma|Prostate Carcinoma
Interventions: OTHER: Exercise Intervention|PROCEDURE: Biospecimen Collection|OTHER: Educational Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety Study of Long-Acting Local Anesthetic
Status: COMPLETED
Conditions: Safety of Neosaxitoxin in Healthy Volunteers
Interventions: DRUG: Neosaxitoxin in saline|DRUG: NeoSTX + bupivacaine 0.2%|DRUG: NeoSTX + bupivacaine 0.2% + epinephrine 5mcg/ml|OTHER: Saline placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Multimodal Educative Data Feedback for Deprescribing BZD and Related Drugs in Outpatients: a Cluster RCT
Status: RECRUITING
Conditions: Deprescription|Benzodiazepine (BZD) and Related Drugs
Interventions: OTHER: Thematic quality circles - Deprescription
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: LISH Trial for the Hepatic Flexure and Proximal Transverse Colon Cancer
Status: RECRUITING
Conditions: Hepatic Flexure Colon Cancer|Proximal Transverse Colon Cancer
Interventions: PROCEDURE: LISH （Laparoscopic Ileocecal-Sparing Right Hemicolectomy）|PROCEDURE: TRH（Traditional Laparoscopic Right Hemicolectomy）
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Association of TTGA (Tissue Transglutaminase Antibody) and Histopathologic Findings in Thyroidectomy Patients
Status: UNKNOWN
Conditions: Thyroid Fibrosis
Interventions: OTHER: Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Impact of Nutritional Intervention in Indian Female Cancer Cachexia Patients
Status: COMPLETED
Conditions: Cachexia|Cancer
Interventions: DIETARY_SUPPLEMENT: Improved Atta|OTHER: Nutritional counseling|BEHAVIORAL: Physical activity counseling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparing Injection Treatments for Tennis Elbow
Status: RECRUITING
Conditions: Tennis Elbow|Lateral Epicondylitis|Elbows Tendonitis
Interventions: DEVICE: Sodium hyaluronate with mannitol (Ostenil Tendon)|DEVICE: Platelet-Rich Plasma Injection|OTHER: Subcutaneous sham injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.
Status: WITHDRAWN
Conditions: Osteoarthritis, Knee
Interventions: DRUG: Methylprednisolone 40 MG Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population
Status: ACTIVE_NOT_RECRUITING
Conditions: Colo-rectal Cancer
Interventions: DIAGNOSTIC_TEST: PBMCs and Tissue expression of HOTTIP ,EIF4EBP1 and serum SNP HOTTIP rs1859168
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Phase 1/2a Study of VK-2019 in Patients With Epstein-Barr Virus (EBV)-Positive Nasopharyngeal Carcinoma (NPC)
Status: TERMINATED
Conditions: Nasopharyngeal Carcinoma|Nasopharyngeal Cancer
Interventions: DRUG: VK-2019
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Monitoring of Exhaled Carbon Monoxide to Promote Pre-operative Smoking Cessation
Status: COMPLETED
Conditions: Smoking
Interventions: BEHAVIORAL: Informing surgical patients about CO monitoring|BEHAVIORAL: a brief intervention recommending preoperative abstinence from smoking
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label, Multicenter Study to Evaluate the Pharmacokinetics, Efficacy and Safety of ASCENIV™ (IGIV) in Pediatric Subjects With Primary Immunodeficiency Diseases (PIDD)
Status: UNKNOWN
Conditions: Primary Immune Deficiency
Interventions: BIOLOGICAL: Asceniv™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Clinical Outcomes of Small-incision Lenticule Extraction (SMILE) Between Different Cap Thickness.
Status: COMPLETED
Conditions: Myopia
Interventions: PROCEDURE: SMILE using 120μm cap thickness|PROCEDURE: SMILE using 140μm cap thickness
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer
Status: TERMINATED
Conditions: Solid Cancers|Non-Hodgkin's Lymphoma
Interventions: DRUG: Fulvestrant|DRUG: GDC-0032|DRUG: Letrozole|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving SUrgery of Liver Metastases: a Trial of the Arterial Chemotherapy Network
Status: COMPLETED
Conditions: Colorectal Cancer Metastatic
Interventions: DRUG: Oxaliplatin, Cetuximab, Bevacizumab, Panitumumab, Irinotecan, Leucovorin, 5-Fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Septal Advancement Flap and Columellar Strut Effect on Nasal Tip
Status: RECRUITING
Conditions: Rhinoplasty
Interventions: PROCEDURE: comparison of septal advancement flap effect on nasal tip in primary rhinoplasty to columellar strut technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Pediatric Caudal Dexmedetomidine Enhances Postoperative Analgesia of Magnesium Sulphate in Lower Abdominal Surgeries
Status: UNKNOWN
Conditions: Pain, Postoperative
Interventions: DRUG: Dexmedetomidine|DRUG: Magnesium Sulphate|DRUG: Bupivacaine|DRUG: Dexmedetomidine + Magnesium Sulphate + Bupivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION