pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Surgery and Vaccine Therapy in Treating Patients With Early Cervical Cancer
Status: COMPLETED
Conditions: Cervical Cancer
Interventions: BIOLOGICAL: human papillomavirus 16 E7 peptide|BIOLOGICAL: synthetic human papillomavirus 16 E6 peptide|PROCEDURE: adjuvant therapy|PROCEDURE: surgical procedure|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Characteristics of Sleep Patterns in Young Adults With and Without Insomnia
Status: COMPLETED
Conditions: Sleep Disorders
Interventions: DRUG: Zolpidem|DRUG: Escitalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Venetoclax and Irinotecan in Relapsed/Refractory SCLC
Status: WITHDRAWN
Conditions: Relapsed Small Cell Lung Cancer|Refractory Small Cell Lung Carcinoma
Interventions: DRUG: Venetoclax 50 MG|DRUG: Venetoclax 100 MG|DRUG: Venetoclax 200 MG|DRUG: Venetoclax 400|DRUG: Venetoclax 600|DRUG: Irinotecan 60 mg/m2|DRUG: Venetoclax (RP2D)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: CVL237 Tablets for APDS/PASLI
Status: NOT_YET_RECRUITING
Conditions: PI3K and P110delta Hyperactivation Syndrome
Interventions: DRUG: CVL237 tablets|DRUG: CVL237 placebo tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma
Status: TERMINATED
Conditions: Mesothelioma
Interventions: DRUG: Vinorelbine|DRUG: Vandetanib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Impact of Pulmonary Rehabilitation on Dyspnea in Chronic Obstructive Pulmonary Disease
Status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Interventions: OTHER: Pulmonary rehabilitation|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COlchicine for Left VEntricular Remodeling Treatment in Acute Myocardial Infarction
Status: COMPLETED
Conditions: Myocardial Infarction
Interventions: DRUG: Colchicine group (experimental arm)|DRUG: Placebo group (control arm)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.
Status: COMPLETED
Conditions: Advanced Cancer|Ovarian Cancer|Breast Cancer|Lung Cancer|Endometrial Cancer|Ovarian Neoplasm|Triple Negative Breast Cancer|Lung Neoplasm|Neoplasm Malignant|Colo-rectal Cancer
Interventions: DRUG: COM701|DRUG: COM701 with Opdivo (Nivolumab).
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers
Status: COMPLETED
Conditions: Electronic Cigarette Use
Interventions: OTHER: RELX ENDS Tobacco Flavor|OTHER: RELX ENDS Menthol Flavor|OTHER: Subject Usual Brand ENDS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Analysis of a Risk-graded and Comprehensive Intervention for Early-childhood-caries
Status: UNKNOWN
Conditions: Early Childhood Caries
Interventions: COMBINATION_PRODUCT: Comprehensive prevention and treatment|COMBINATION_PRODUCT: Routine prevention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Ibrutinib|DRUG: Omeprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Three-dimensional (3D) Printed Hemodialysis Vascular Model
Status: NOT_YET_RECRUITING
Conditions: Hemodialysis Access Failure
Interventions: DEVICE: The three-dimensional (3D) printed hemodialysis vascular model
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Exploration of Neuropathic Pain Induced by Oxaliplatin Electrophysiological Approach
Status: COMPLETED
Conditions: Peripheric Neuropathy|Chemo-induced Neuropathy
Interventions: DEVICE: Assessment of neuropathic pain with theThermotest device|DEVICE: Assessment of neuropathic pain with SUDOSCAN device|DEVICE: Assessment of neuropathic pain with the Neuropathic Pain Symptom Inventory.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Primary Generalized Tonic-Clonic Seizures (PGTC) Seizures
Status: COMPLETED
Conditions: Epilepsy, Tonic-Clonic
Interventions: DRUG: lamotrigine (LAMICTAL) extended-release|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Real-World Study of Vivity Intraocular Lenses (IOLs)
Status: WITHDRAWN
Conditions: Aphakia|Presbyopia
Interventions: DEVICE: AcrySof IQ Vivity Extended Vision IOL|PROCEDURE: Cataract surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Forms of OMT as Methods for Reducing Snoring and Mild to Moderate Sleep Apnea
Status: ENROLLING_BY_INVITATION
Conditions: Sleep Apnea, Obstructive|Snoring
Interventions: DEVICE: IQoro|DEVICE: eXciteosa|BEHAVIORAL: Grouptraining
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Postoperative Analgesia With Quadratus Lumborum Block(QLB) And Dexamethasone As An Adjuvant To Bupivacaine.
Status: COMPLETED
Conditions: Post Operative Pain|Quadratus Lumborum Block|Pediatric|Abdominal Surgery
Interventions: PROCEDURE: ultrasound guided quadratus lumborum block|DRUG: Dexamethasone Phosphate 4 MG/ML Injectable Solution intravenously|DRUG: Bupivacaine Injection|DRUG: Dexamethasone Phosphate 4 MG/ML Injectable Solution locally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study in Infants (6-12 Months) Comparing Two Doses of a Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Vaccine Versus a Tetanus Toxoid-Conjugated Vaccine Available for the Prevention of Haemophilus Influenzae Type b Infections in China
Status: COMPLETED
Conditions: Haemophilus Influenzae Type b (Hib) Infection
Interventions: BIOLOGICAL: Haemophilus influenzae type b (Hib) vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: The Efficacy of PRP Combined With Exercise to Treat Knee Osteoarthritisq
Status: COMPLETED
Conditions: Platelet-rich Plasma|Physical Exercise|Knee Osteoarthritis
Interventions: DRUG: platelet-rich plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Investigate the Safety and Tolerability of AZD6244 Monotherapy or + Docetaxel in Japanese Patients With Advanced Solid Malignancies or Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Neoplasms,|Metastatic Cancer,|Non-Small Cell Lung Cancer|Advanced Solid Malignancies
Interventions: DRUG: AZD6244
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Treatment ALK(+) Systemic Anaplastic Large Cell Lymphoma With Crizotinib
Status: WITHDRAWN
Conditions: Systemic Anaplastic Large-Cell Lymphoma
Interventions: DRUG: crizotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance in Older People
Status: COMPLETED
Conditions: Regional Blood Flow
Interventions: BEHAVIORAL: Old Exercise|DIETARY_SUPPLEMENT: Old Acute Cocoa|DIETARY_SUPPLEMENT: Old 7 Day Cocoa
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Motor Inhibition in Parkinson's Disease and Focal Hand Dystonia
Status: UNKNOWN
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Behavioral data|DIAGNOSTIC_TEST: Single-pulse transcranial magnetic stimulation (TMS)|OTHER: Questionnaires|OTHER: MDS (Movement Disorder Society) UPDRS (Unified Parkinson's Disease Rating Scale) Part 3 (Motor Part)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Compare the Effectiveness and Safety of IBI310 Combined With Sintilimab Versus Sorafenib in the First-line Treatment of Advanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: IBI310|DRUG: Sintilimab|DRUG: Sorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunogenicity and Persistence of Hepatitis B Vaccination in Methadone Maintenance Treatment Patients
Status: UNKNOWN
Conditions: Hepatitis B Vaccine
Interventions: BIOLOGICAL: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6|BIOLOGICAL: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6|BIOLOGICAL: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Pemetrexed or Docetaxel With or Without Erlotinib in Stage IIIB or Stage IV Non-Small Cell Lung Cancer
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: erlotinib hydrochloride|DRUG: pemetrexed disodium|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy of Supralimus™ Core™ Sirolimus Eluting Stent at MAX DDHV Institute
Status: COMPLETED
Conditions: Coronary Artery Disease
Interventions: DEVICE: Supralimus-Core™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Gene Therapy for Chronic Granulomatous Disease
Status: TERMINATED
Conditions: Chronic Granulomatous Disease
Interventions: DRUG: Phagocyte Oxidase Subunit Transduced CD34 Hematopoietic Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Immunotherapy of Melanoma Patients
Status: COMPLETED
Conditions: Melanoma
Interventions: BIOLOGICAL: Melan-A analog peptide|BIOLOGICAL: FluMa peptide|BIOLOGICAL: Mage-A10 peptide|BIOLOGICAL: SB AS-2 adjuvant|BIOLOGICAL: Montanide adjuvant
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions
Status: TERMINATED
Conditions: High Grade Anal Canal Intraepithelial Neoplasia|High Grade Vulvar Squamous Intraepithelial Lesion
Interventions: OTHER: Laboratory Biomarker Analysis|OTHER: Placebo Administration|OTHER: Questionnaire Administration|BIOLOGICAL: Recombinant Human Papillomavirus Nonavalent Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of TCM on Beta-cell Function and Insulin Resistance in High Risk Chinese Individuals for T2D (TCM_PDiab_P01)
Status: UNKNOWN
Conditions: Prediabetic State
Interventions: OTHER: Rhizoma Coptidis, Radix Astragali and Flos Lonicerae|OTHER: Rhizoma Coptidis, Radix Astragali and Flos Lonicerae, Ophiopogonis Radix
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Progestin-Only Pill Use and Breastfeeding Study
Status: COMPLETED
Conditions: Contraception|Breastfeeding
Interventions: DRUG: Progestin Only Contraceptive Pills
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Periodontal Therapy in Patients With Metabolic Syndrome
Status: COMPLETED
Conditions: Periodontitis|Metabolic Syndrome
Interventions: PROCEDURE: Scaling and root planning|PROCEDURE: Supragingival Prophylaxis
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Impact of Fruit Juice, Fruit Juice With Pomace, or Whole Fruit on Glycemic Response
Status: COMPLETED
Conditions: Glycemic Response
Interventions: OTHER: Whole oranges|OTHER: Whole Apples|OTHER: Orange juice + orange pomace|OTHER: Apple juice + apple pomace|OTHER: Orange juice|OTHER: Apple juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Efficacy and Safety of Sodium Heparin in Patients Submitted to Heart Surgery Using Bypass
Status: UNKNOWN
Conditions: Cardiac Surgery
Interventions: DRUG: heparin sodium - Bergamo|DRUG: heparin sodium - APP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Anti-viral Therapy in Alzheimer's Disease
Status: ACTIVE_NOT_RECRUITING
Conditions: Alzheimer Disease|Herpes Simplex 1|Herpes Simplex 2
Interventions: DRUG: Valacyclovir|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery
Status: COMPLETED
Conditions: Pain, Postoperative|Pelvic Organ Prolapse
Interventions: DRUG: Ice T|DRUG: Motrin/Percocet/Dilaudid for breakthrough
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: KX01 Ointment Phase 1 Study in Patients With Plaque Type Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: KX01 0.01% (0.1 mg/g)|DRUG: Placebo|DRUG: KX01 0.1% (1.0 mg/g)|DRUG: KX01 1% (10 mg/g) for 5 days|DRUG: KX01 1% (10 mg/g) for consecutive 5 days and 2 days rest for 1 cycle, and repeat up to 4 cycles
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Low Level Laser Therapy After Wisdom Tooth Removal
Status: UNKNOWN
Conditions: Tooth, Impacted|Wound Heal|Quality of Life
Interventions: DEVICE: Use of Low level Laser after wisdom tooth removal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Skill Birth Attendant Training to Improve the Competency of Service Providers
Status: ACTIVE_NOT_RECRUITING
Conditions: Competencies of Midwives|Cost-benefit Analysis of Modular Training
Interventions: BEHAVIORAL: Skill birth attendant training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients
Status: UNKNOWN
Conditions: SARS-CoV Infection|COVID 19|Acute Respiratory Distress Syndrome ARDS
Interventions: DRUG: Hydroxychloroquine|DRUG: Remdesivir|OTHER: (Standard of Care) SoC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Extracorporeal Shock Wave Therapy in Children With Cerebral Palsy
Status: NOT_YET_RECRUITING
Conditions: Spasticity/Paresis|Cerebral Palsy
Interventions: DEVICE: ESWT|DRUG: Botulinum Toxin Type A|OTHER: Serial Casting|BEHAVIORAL: Physical Therapy|BEHAVIORAL: Occupational Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase 1 Study of the Safety, Reactogenicity, and Immunogenicity of AMA1-C1/ISA 720: Blood Stage Vaccine for Plasmodium Falciparum
Status: COMPLETED
Conditions: Malaria
Interventions: DRUG: AMA1-C1/ISA 720
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Comparison Of INIT Versus NMR in Patients With Deep Gluteal Syndrome
Status: COMPLETED
Conditions: Deep Gluteal Syndrome
Interventions: OTHER: Integrated Neuromuscular Inhibition Technique|OTHER: Neuromuscular Reeducation Technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Custodiol Versus Blood Cardioplegaia in Paediatric Cardiac Surgery
Status: COMPLETED
Conditions: Congenital Heart Disease
Interventions: DRUG: Custodiol Solution|DRUG: Blood cardioplegia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Interest of the Dermabrasion by Laser Erbium in the Treatment of the Vitiligo
Status: COMPLETED
Conditions: Vitiligo
Interventions: DEVICE: Group Laser = Arm A|DRUG: Bras B : The group control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Sorafenib In Combination With Low-dose 5-fluorouracil/Cisplatin (FP) Intraarterial Infusion Chemotherapy
Status: COMPLETED
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: sorafenib, cisplatin, fluorouracil
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies
Status: COMPLETED
Conditions: Pneumonia, Pneumocystis Carinii|HIV Infections
Interventions: DRUG: Trimetrexate glucuronate|DRUG: Leucovorin calcium
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Exercise Facilitator to Activate Simple Training Programs in the Dialysis Center
Status: UNKNOWN
Conditions: Chronic Kidney Disease Stage 5 on Dialysis
Interventions: OTHER: Home-based unstructured physical activity program|OTHER: Home-based structured low-intensity physical activity program|OTHER: In-hospital structured supervised physical activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Extension Study of BIIB092 in Participants With Progressive Supranuclear Palsy (PSP) Who Participated in CN002003
Status: TERMINATED
Conditions: Supranuclear Palsy, Progressive
Interventions: DRUG: BIIB092
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing Outcome Measures in Stroke Rehabilitation
Status: RECRUITING
Conditions: Stroke|Upper Extremity Dysfunction|Hemiplegia|Hemiparesis|Knowledge, Attitudes, Practice
Interventions: BEHAVIORAL: I-STROM
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Open Label, Controlled, Post Marketing, Registry Study of Ribociclib (Ribo) Treatment Adherence and Patient Reported Outcomes in Participants Using ReX Technology Platform
Status: RECRUITING
Conditions: Any Solid Oral Medication
Interventions: DEVICE: Use of ReX to dispense and monitor solid oral medication therapy.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Minimally Invasive Three-dimensional Knee Kinematic Assessment and Surgical Guidance Using Ultrasonic Rigid Registration
Status: NOT_YET_RECRUITING
Conditions: Knee Osteoarthritis|Knee Instability|3D Knee Kinematics|Precision of Surgical Actions|Clinical Outcomes
Interventions: DEVICE: Repeated Measurements of Knee Alignment and Kinematics|DEVICE: Computer Guidance of Surgical Actions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Kadcyla In pAtients With bRAin Metastasis
Status: WITHDRAWN
Conditions: Metastatic HER2-positive Breast Cancer With Brain Metastasis
Interventions: DRUG: KADCYLA 160 MG Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs DOACs)
Status: COMPLETED
Conditions: Atrial Fibrillation|Ischemic Stroke|Systemic Embolization|Major Bleed|Myocardial Infarction|All-cause Mortality
Interventions: DRUG: Apixaban (ATC B01AF02)|DRUG: Dabigatran (ATC B01AE07)|DRUG: Rivaroxaban (ATC B01AF01)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
Status: RECRUITING
Conditions: Helicobacter Pylori Infection|Helicobacter Pylori Eradication
Interventions: DRUG: group A : Amoxicillin Esomeprazole HDDT|DRUG: group-B : Levofloxacin triple therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of Self-foot Exercise on the Incidence of Plantar Foot Diabetic Ulcer Recurrence
Status: COMPLETED
Conditions: Diabetic Foot Ulcer|Diabetic Foot
Interventions: OTHER: self-structured foot exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Combination Chemotherapy With Nintedanib / Placebo in Endometrial Cancer
Status: COMPLETED
Conditions: Endometrial Cancer
Interventions: DRUG: Nintedanib or Placebo; Carboplatin, Paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of Perineural Dextrose Injection in Patients With Ulnar Neuropathy at the Elbow
Status: COMPLETED
Conditions: Ulnar Neuropathies
Interventions: OTHER: 5 cc 5% Dextrose solution|OTHER: 5 cc salin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Tibial Nerve Block Versus Single Shot Tibial Nerve Block
Status: WITHDRAWN
Conditions: Hallux Valgus
Interventions: DRUG: Single injection posterior tibial nerve block|DRUG: Posterior tibial nerve catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety
Status: COMPLETED
Conditions: Congenital Hyperinsulinism|Neuroblastoma|Neuroendocrine Tumors|Parkinson Disease|Brain Glioma
Interventions: DRUG: 18F-DOPA
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: RCT of a Mobile Phone App-based Intervention for Parents of Children With Autism Spectrum Disorder (ASD)
Status: RECRUITING
Conditions: Autism Spectrum Disorder|Parent-Child Relations
Interventions: OTHER: Mobile phone app-based intervention for supporting and empowering parents of children with autism spectrum disorder (ASD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Hip Strengthening Exercises and Pelvic Floor Exercises on Stress Urinary Incontinence in Postnatal Women
Status: ACTIVE_NOT_RECRUITING
Conditions: Stress Urinary Incontinence
Interventions: OTHER: expremental pre and post test
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Lenvatinib Combined With TACE and Camrelizumab in Conversion Resection for Advanced Hepatocellular Carcinoma (LEN-TAC Study)
Status: RECRUITING
Conditions: Advanced Hepatocellular Carcinoma
Interventions: COMBINATION_PRODUCT: Lenvatinib combined with TACE and Camrelizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial of HRS-2261 in Healthy Subjects After Single and Multiple Oral Administration
Status: COMPLETED
Conditions: Chronic Cough
Interventions: DRUG: HRS-2261 tablet、placebo|DRUG: HRS-2261 tablet、placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Antidepressant Maintenance in Traumatic Brain Injury
Status: UNKNOWN
Conditions: Depression
Interventions: DRUG: citalopram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Dietary Protein Source on Phosphaturia, PTH and FGF23 in Patients With CKD 3 and 4
Status: COMPLETED
Conditions: Chronic Kidney Disease
Interventions: OTHER: grain (soy) protein diet|OTHER: casein (meat) protein diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Atezolizumab in Treating Patients With Recurrent BCG-Unresponsive Non-muscle Invasive Bladder Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Recurrent Bladder Urothelial Carcinoma|Stage 0a Bladder Urothelial Carcinoma AJCC v6 and v7|Stage 0is Bladder Urothelial Carcinoma AJCC v6 and v7|Stage I Bladder Urothelial Carcinoma AJCC v6 and v7
Interventions: DRUG: Atezolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Safety and Efficacy of a New Formulation of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution in Patients With Dry Eye Disease
Status: RECRUITING
Conditions: Dry Eye Disease
Interventions: DRUG: rhNGF concentration 1|DRUG: rhNGF concentration 2|DRUG: Vehicle (Placebo solution)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Continuous Positive Airway Pressure Via Binasal Prong vs Nasal Mask: a Randomised Controlled Trial
Status: COMPLETED
Conditions: Bronchopulmonary Dysplasia|Death
Interventions: DEVICE: Easy Flow system and INCA® nasal cannulae set
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: EEG (Electroencephalogram) Platform Standardization in Healthy Male Subjects (3134-010)
Status: COMPLETED
Conditions: Dementia
Interventions: DRUG: MK3134|DRUG: Comparator: Lorazepam|DRUG: Comparator: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Sufentanil on the Rate of Anesthesia
Status: COMPLETED
Conditions: Irreversible Pulpitis
Interventions: DRUG: Lidocaine with Epinephrine+ Normal saline|DRUG: Lidocaine with Epinephrine + sufentanil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Acs-Tens Treatment for Faecal Incontinence: a RCT With Sham-controls
Status: COMPLETED
Conditions: Faecal Incontinence|Faecal Incontinence With Faecal Urgency|Neuromodulation|Transcutaneous Electric Nerve Stimulation|Acupuncture Points
Interventions: PROCEDURE: AcuTENS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of ZL-2306 (Niraparib) as Maintenance Treatment Following First-line Chemotherapy in Patients With Advanced Ovarian Cancer
Status: UNKNOWN
Conditions: Ovarian Cancer
Interventions: DRUG: ZL-2306 (Nirapairb)|DRUG: Placebo Comparator
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Self-Assessment Method for Statin Side-effects Or Nocebo
Status: COMPLETED
Conditions: Adverse Effects|Cardiovascular Diseases|Hyperlipidemias
Interventions: DRUG: Atorvastatin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Hematopoietic Stem Cell Transplantation in Patients With Antiphospholipid Syndrome
Status: WITHDRAWN
Conditions: ANTIPHOSPHOLIPID SYNDROME
Interventions: BIOLOGICAL: Stem Cell Transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ridge Preservation Using a Ossix™ Bone vs Bio-Oss® Collagen
Status: COMPLETED
Conditions: TEETH EXTRACTION
Interventions: DEVICE: Ossix™ Bone|DEVICE: Bio-Oss® Collagen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Safety and Tolerability Study of UBX0101 in Patients With Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis, Knee
Interventions: DRUG: UBX0101|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Rhythm Experience and Africana Culture Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Cognitive Performance|Brain Structure
Interventions: BEHAVIORAL: African Dance|BEHAVIORAL: African Cultural Immersion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of Nasonex in the Relief of Nasal Congestion in Patients With Seasonal Allergic Rhinitis (Study P05583)
Status: COMPLETED
Conditions: Allergic Rhinitis
Interventions: DRUG: Mometasone furoate nasal spray (MFNS)|DRUG: Matching placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis
Interventions: COMBINATION_PRODUCT: Pure PRP II|COMBINATION_PRODUCT: PureBMC
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Improving Ambulatory Community Access After Paralysis
Status: UNKNOWN
Conditions: Stroke|Partial Paralysis|Spinal Cord Injury|Tetraplegia|Quadriplegia
Interventions: DEVICE: IRS-8 (8 channel implanted receiver stimulator)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Status: RECRUITING
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: PROCEDURE: Microbiome Transplant|PROCEDURE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of the Cardiac Effects of ALXN1840 in Healthy Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: ALXN1840|DRUG: Placebo|DRUG: Moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DRUG: Metformin|DRUG: Oral Contraceptive Pill|BEHAVIORAL: Lifestyle Management Program|BEHAVIORAL: Quality of Life Questionnaire|PROCEDURE: Oral Glucose Tolerance Test|PROCEDURE: Blood work|PROCEDURE: Abdominal Ultra Sound|PROCEDURE: Dual-energy x-ray absorptiometry (DEXA scan)|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR) for Tongue Dysphagia
Status: RECRUITING
Conditions: Oropharyngeal Dysphagia
Interventions: DRUG: Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Evaluation of the Safety of Oncocort IV Pegylated Liposomal Dexamethasone Phosphate in Patients With Progressive Multiple Myeloma
Status: TERMINATED
Conditions: Multiple Myeloma
Interventions: DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Fenofibric Acid Versus Tricor® (Fenofibrate)
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Fenofibric Acid (Fibricor™) 105 mg Tablet|DRUG: Fenofibrate (Tricor®) 145 mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Prospective Evaluation of Gastrointestinal and Genitourinary Side Effects of Pelvic Radiotherapy
Status: UNKNOWN
Conditions: Radiotherapy Side Effects
Interventions: OTHER: NCI PRO-CTCAE Questionnaire / EORTC QLQ-C30 Questionnaire
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Research on the Correlation Between Organoid Drug Sensitivity Testing and Precise Treatment of Gastrointestinal Tumors
Status: RECRUITING
Conditions: Gastrointestinal Tumors，3D Organoids，Drug Sensitivity
Interventions: OTHER: Based on diagnostic and treatment guidelines/expert consensus, as well as clinical treatment experience, it is recommended that no more than 9 drugs be used for drug sensitivity testing each time.
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Combination of Sorafenib With Standard Therapy in Newly Diagnosed Adult CBF AML
Status: UNKNOWN
Conditions: Core Binding Factor Acute Myeloid Leukemia
Interventions: DRUG: Sorafenib|DRUG: Idarubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Real-World Evaluation of the Effect of Jublia on Nail Polish
Status: COMPLETED
Conditions: Evaluation of Jublia on Nail Polish With Healthy Toenails
Interventions: DRUG: Nail Polish + Efinaconazole Solution|OTHER: Nail polish|DRUG: Base Coat + Nail Polish + Top Coat + Efinaconazole Solution|DRUG: Nail Polish + Top Coat + Efinaconazole Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Quadriblock Versus "IPACK + Femoral Triangle Block + Obturator Nerve Block" in Total Knee Arthroplasty
Status: COMPLETED
Conditions: Primary Total Knee Arthroplasty
Interventions: PROCEDURE: IPACK|PROCEDURE: Femoral triangle block|PROCEDURE: Obturator nerve block|PROCEDURE: Femoral nerve block|PROCEDURE: Sciatic nerve block|PROCEDURE: Lateral femoral cutaneous nerve block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Foley Catheter Compared to the Foley Catheter Alone for Cervical Ripening
Status: COMPLETED
Conditions: Cervical Ripening|Induction of Labor
Interventions: DRUG: Cervidil 10 MG Vaginal Insert|DEVICE: Foley Catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer
Interventions: DRUG: fluorouracil|DRUG: leucovorin calcium|DRUG: oxaliplatin|PROCEDURE: conventional surgery|RADIATION: radiation therapy|OTHER: laboratory biomarker analysis|GENETIC: DNA analysis|GENETIC: polymerase chain reaction|OTHER: immunohistochemistry staining method
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of EO-3021 in Adult Patients With Solid Tumors Likely to Express CLDN18.2
Status: RECRUITING
Conditions: Pancreas Neoplasm|Stomach Neoplasm|Gastrointestinal Neoplasms|Digestive System Neoplasm|Neoplasms by Site|Neoplasms
Interventions: DRUG: EO-3021
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Efficacy and Safety of the VEGFR-FGFR Inhibitor, Lucitanib, Given to Patients With Advanced/Metastatic Lung Cancer and FGF, VEGF, or PDGF Related Genetic Alterations
Status: TERMINATED
Conditions: Non-Small Cell Lung Cancer|Squamous Non-Small Cell Lung Cancer|NSCLC|Small Cell Lung Cancer|SCLC|Lung Cancer|Advanced Lung Cancer|Metastatic Lung Cancer|Stage IV Lung Cancer
Interventions: DRUG: Lucitanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers
Status: NOT_YET_RECRUITING
Conditions: Colorectal Carcinoma
Interventions: OTHER: Best Practice|OTHER: Communication Intervention|OTHER: Communication Intervention|OTHER: Coordination|OTHER: Educational Intervention|OTHER: Electronic Health Record Review|OTHER: Electronic Health Record Review|OTHER: Informational Intervention|OTHER: Informational Intervention|OTHER: Interview|BEHAVIORAL: Patient Navigation|OTHER: Referral|OTHER: Referral|OTHER: Text Message-Based Navigation Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Study in End-stage Renal Disease Patients Awaiting Kidney Transplant to Investigate the Potential Effect of IVIG Treatment on the Pharmacokinetics and Pharmacodynamics of LFG316
Status: COMPLETED
Conditions: Kidney Transplantation
Interventions: DRUG: LFG316|DRUG: IVIG
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mesalamine Pellet Formulation to Maintain Remission of Mild to Moderate Ulcerative Colitis
Status: COMPLETED
Conditions: Ulcerative Colitis
Interventions: DRUG: Granulated mesalamine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: PREVENTION
Clinical trial: A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (Sustained HBsAg Loss) (A)
Status: NOT_YET_RECRUITING
Conditions: Chronic Hepatitis b|Anti-PD-1 Antibody
Interventions: DRUG: Anti-PD-1 antibody|DRUG: NAs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Using Computers to Assist in Parental Smoking Cessation in a Pediatric Setting
Status: COMPLETED
Conditions: Cigarette Smoking
Interventions: OTHER: CHICA Smoking Cessation Module|OTHER: CHICA Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Camrelizumab Combined With Neoadjuvant Concurrent Chemoradiotherapy for Resectable Locally Advanced ESCC（NICE-RT）
Status: NOT_YET_RECRUITING
Conditions: Esophageal Squamous Cell Carcinoma
Interventions: DRUG: Chemotherapy (nab-paclitaxel AUC=2 and carboplatin 80mg/m2)，Immunotherapy (camrelizumab 200mg)、Radiotherapy(primary lesion and adjacent lymph nodes 41.4Gy， distant lymph node 0.5Gy*4)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Video-Based Intervention in Reducing Anxiety in Patients Undergoing Lung Cancer Screening
Status: COMPLETED
Conditions: Anxiety|No Evidence of Disease|Lung Carcinoma
Interventions: OTHER: educational intervention|OTHER: questionnaire administration|OTHER: quality-of-life assessment|OTHER: Best Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of Multiple Strain Probiotics Reduces the Neurobehavioral Disorder in Premature Very Low Birth Weight Infants
Status: WITHDRAWN
Conditions: Very Low Birth Weight Infants
Interventions: OTHER: Mixture probiotics|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Roflumilast on Quality of Life, Lung Function and Mucus Properties in Patients With Bronchiectasis
Status: UNKNOWN
Conditions: Bronchiectasis Adult
Interventions: DRUG: Roflumilast|DRUG: Placebo oral tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays
Status: COMPLETED
Conditions: Otitis Media, Serous|Negative Middle Ear Pressure|Rhinitis|Otitis Media With Effusion|Otitis Media, Secretory
Interventions: DRUG: Triamcinolone acetonide nasal spray|DRUG: Placebo nasal spray
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder
Status: TERMINATED
Conditions: Overactive Bladder
Interventions: BIOLOGICAL: Normal saline (Placebo); botulinum toxin Type A (200U)|BIOLOGICAL: botulinum toxin Type A (50U); botulinum toxin Type A (200U)|BIOLOGICAL: botulinum toxin Type A (100U); botulinum toxin Type A (200U)|BIOLOGICAL: botulinum toxin Type A (200U)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Man Van Project
Status: RECRUITING
Conditions: Prostate Cancer|Urologic Cancer|Urologic Diseases|Bladder Cancer|Diabetes|Hypertension|Mental Health Issue|Alcoholism|Smoking|Renal Cancer|Testis Cancer
Interventions: DEVICE: MV-POCT Sub-study|OTHER: Main Man Van Group Sub-study (MV-Eco)|OTHER: MV-QualQ Sub-study|DIAGNOSTIC_TEST: MV-PRS Sub-study|OTHER: MV-DNA and MV-UctDNA Sub-study|OTHER: Man Van patients|OTHER: MV-SSI Sub-study|OTHER: MV-TPP Sub-study
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Motor Imagery and Motor Execution Based BCI in Stroke
Status: RECRUITING
Conditions: Stroke|Neurorehabilitation|Motor Imagery|Motor Execution|Brain-computer Interface
Interventions: DEVICE: Motor imagery and motor execution based BCI|DEVICE: Sham BCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Fruit and Vegetable Prescription Program
Status: RECRUITING
Conditions: Diabetes Mellitus|Diabetes Complications
Interventions: BEHAVIORAL: Usual Care|BEHAVIORAL: F&V Rx alone|BEHAVIORAL: F&V Rx plus DSME/S
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pembrolizumab and Lenvatinib After Definitive Chemoradiation of Locally Advanced HNSCC
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma
Interventions: DRUG: Pembrolizumab|DRUG: Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT