pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: High-dose ICE With Amifostine
Status: COMPLETED
Conditions: Bladder Cancer|Brain and Central Nervous System Tumors|Carcinoma of Unknown Primary|Extragonadal Germ Cell Tumor|Head and Neck Cancer|Kidney Cancer|Lung Cancer|Ovarian Cancer|Sarcoma|Testicular Germ Cell Tumor|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: BIOLOGICAL: filgrastim|DRUG: Amifostine|DRUG: Carboplatin|DRUG: Etoposide|DRUG: Ifosfamide|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Add-on Study to Evaluate the Efficacy and Safety of Xiyanping Injection in Pediatric Bronchitis Patients.
Status: UNKNOWN
Conditions: Bronchitis
Interventions: DRUG: Standard treatment only|DRUG: Standard treatment+Xiyanping injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 2: Train-the-Trainer
Status: COMPLETED
Conditions: Sleep Disorder|Circadian Dysregulation
Interventions: BEHAVIORAL: Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)|BEHAVIORAL: Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)|OTHER: Usual Care Delayed Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SYNCED - SYNChronized Eating in Bipolar Depression Study
Status: NOT_YET_RECRUITING
Conditions: Bipolar Depression|Bipolar I Disorder|Bipolar II Disorder
Interventions: BEHAVIORAL: Time restricted eating|BEHAVIORAL: Eating ad libitum with nutritional counselling
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: N-Acetylcysteine and Smoking Reduction
Status: COMPLETED
Conditions: Nicotine Dependence
Interventions: DRUG: N-acetylcysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Predictive Role of Programmed Death Ligand 1 (PD-L1) and Neutrophil to Lymphocyte Ratio (NLR) in Non-Small Cell Lung Cancer (NSCLC)
Status: UNKNOWN
Conditions: To Define an Easy and Feasible Panel Which May be Routinely Applied to Select Patients for Immunotherapy Avoiding More Complex and Expensive Methods
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Bioequivalence Study Comparing Methylprednisolone Suspension To Methylprednisolone Tablets Under Fasting Conditions
Status: WITHDRAWN
Conditions: Therapeutic Equivalency
Interventions: DRUG: methylprednisolone|DRUG: methylprednisolone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Early Initiation of High-flow Nasal Cannula Oxygen Therapy in Patients With Acute Respiratory Failure in the Emergency Department: A Before-after Study
Status: COMPLETED
Conditions: Acute Respiratory Failure
Interventions: DEVICE: High-flow oxygen|DEVICE: Standard oxygen
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Effect of Multifunctional Nutrition Tube on Cerebral Small Vessel Disease Patients
Status: RECRUITING
Conditions: Cerebral Small Vessel Diseases|Dysphagia
Interventions: DEVICE: Intermittent Oro-esophageal Tube Feeding|DEVICE: Nasogastric Tube Feeding|BEHAVIORAL: comprehensive rehabilitation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of the Cognitive Enhancing ICT Contents in Patients With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: OTHER: Cognitive rehabilitation program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Fruit and Vegetable Intake on Markers of Fruit and Vegetable Consumption
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: 2 portions of fruit and vegetables per day|DIETARY_SUPPLEMENT: 5 portions of fruit and vegetables per day|DIETARY_SUPPLEMENT: 8 portions of fruit and vegetables per day
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Role of Cardiovascular Magnetic Resonance in Patients With Non-ST- Elevation- Myocardial Infarction
Status: RECRUITING
Conditions: Non-ST Elevation Myocardial Infarction (NSTEMI)
Interventions: DIAGNOSTIC_TEST: Cardiovascular Magnetic Resonance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Sensory-Targeted Ankle Rehabilitation Strategies (STARS)
Status: COMPLETED
Conditions: Chronic Ankle Instability
Interventions: OTHER: Ankle Joint Mobilization|OTHER: Foot Massage|OTHER: Calf Stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer
Status: COMPLETED
Conditions: Acute Gastritis|Gastric Ulcer
Interventions: DRUG: Selbex|DRUG: Selbex
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
Status: RECRUITING
Conditions: Myeloproliferative Disorders|Essential Thrombocythemia|Neoplasms|Myelofibrosis
Interventions: DRUG: JNJ-88549968
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Performance of Nanohybrid Resin Composite Lined With PRG Barrier Coat Compared to Resin Modified Glass Ionomer in Class V Carious Cavities Over 18 Months: Randomized Clinical Trial
Status: NOT_YET_RECRUITING
Conditions: Class V Dental Caries
Interventions: DEVICE: PRG barrier coat + nanohybrid composite|DEVICE: resin modified glass ionomer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetics Study of ALO-02 and OxyContin
Status: COMPLETED
Conditions: Management of Moderate to Severe Pain
Interventions: DRUG: ALO-02|DRUG: Naltrexone block|DRUG: ALO-02|DRUG: Naltrexone block|DRUG: OxyContin|DRUG: Naltrexone block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study to Assess the Safety, Tolerability, PK and PD Response of PE0139 Injection in Adult Subjects With T2DM
Status: COMPLETED
Conditions: Type 2 Diabetes Mellitus
Interventions: DRUG: PE0139 Injection|DRUG: Placebo Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bone Marrow Versus Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: BIOLOGICAL: Bone marrow aspirate concentrate injection|BIOLOGICAL: intra-articular injection of Minimally manipulated adipose tissue
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of a Single Intravitreal Anti-VEGF Therapy on Optic Nerve Head Perfusion
Status: TERMINATED
Conditions: Macular Degeneration|Regional Blood Flow|Vascular Endothelial Growth Factor
Interventions: DRUG: ranibizumab, bevacizumab or pegaptanib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study to Establish Safety and Maximum Tolerated Dose of IV Trehalose in Healthy Subjects
Status: COMPLETED
Conditions: Healthy Volunteer Subjects
Interventions: DRUG: Trehalose for IV Infusion|DRUG: Saline 0.9% IV
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Study to Assess the Pharmacodynamics of VK0214 in Male Subjects With AMN
Status: RECRUITING
Conditions: Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD)
Interventions: DRUG: VK0214|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: The Chocolate Touch Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Peripheral Artery Disease (PAD)|Ischemia|Intermittent Claudication
Interventions: DEVICE: Chocolate Touch|DEVICE: Lutonix Drug Coated Balloon
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Delivery of Polyphenols in Gum as an Anti-Caries Agent
Status: COMPLETED
Conditions: Dental Caries
Interventions: OTHER: Chewing gum containing xylitol and blackberry extract (BBE)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
Status: COMPLETED
Conditions: Adverse Effect
Interventions: DRUG: Phenylephrine|DRUG: Norepinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of SUDOKU Mind Activation & Revitalizing Training on Cognitive Function in People With Mild Cognitive Impairment
Status: COMPLETED
Conditions: Mild Cognitive Impairment
Interventions: BEHAVIORAL: 24-week SUDOKU Training Programme|OTHER: Control Arm (wait-list)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy and Safety Study of Benralizumab in Adults and Adolescents Inadequately Controlled on Inhaled Corticosteroid Plus Long-acting β2 Agonist
Status: COMPLETED
Conditions: Asthma
Interventions: BIOLOGICAL: Benralizumab|BIOLOGICAL: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Electroacupuncture Pain Treatment, Mechanical Hyperalgesia, Quality of Life & Expression of Mu+ B Cells in Fibromyalgia
Status: RECRUITING
Conditions: Fibromyalgia|Electroacupuncture|Acupuncture|Hyperalgesia
Interventions: OTHER: Electroacupuncture|DIETARY_SUPPLEMENT: Nutrition|DIETARY_SUPPLEMENT: Dietary supplement
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: OsteoArthritis and Therapy for Sleep
Status: UNKNOWN
Conditions: Insomnia Related to Osteoarthritis Pain
Interventions: BEHAVIORAL: Cognitive Behavior Therapy for Insomnia|BEHAVIORAL: Education Only Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise in the Physiotherapy Management of Shoulder Impingement
Status: UNKNOWN
Conditions: Subacromial Impingement Syndrome
Interventions: OTHER: Evidence based exercise protocol|OTHER: Usual physiotherapy without exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis
Status: COMPLETED
Conditions: Nonallergic Irritant Rhinitis
Interventions: DRUG: Capsaicin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor
Status: COMPLETED
Conditions: Cystic Fibrosis
Interventions: DRUG: VX-661 Plus Ivacaftor Combination|DRUG: Ivacaftor|DRUG: VX-661 Plus Ivacaftor Combination Placebo|DRUG: Ivacaftor placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation
Status: COMPLETED
Conditions: Healthy|Osteoarthritis
Interventions: DRUG: Trichomylin for SAD|DRUG: Placebo for SAD|DRUG: Trichomylin for MAD|DRUG: Placebo for MAD
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Aldoxorubicin Compared to Topotecan in Subjects With Metastatic Small Cell Lung Cancer
Status: COMPLETED
Conditions: Metastatic Small Cell Lung Cancer
Interventions: DRUG: Aldoxorubicin|DRUG: Topotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Aromatherapy Massage Applied to Hemodialysis Patients With Muscle Cramp
Status: COMPLETED
Conditions: Muscle Cramps|Aromatherapy|Hemodialysis|Quality of Life|Pain
Interventions: OTHER: Lavandula angustifolia, Rosmarinus officinalis L. and Origanum majorana L.|OTHER: Baby oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Extracorporeal Photopheresis for Medicare Recipients of Lung Allografts
Status: ACTIVE_NOT_RECRUITING
Conditions: Bronchiolitis Obliterans Syndrome (BOS)
Interventions: COMBINATION_PRODUCT: Extracorporeal Photopheresis (ECP)|OTHER: No intervention in the SOC / Retrospective Chart review.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Open-Label Extension Study to Evaluate the Safety of Efgartigimod in Adult Patients With Primary Sjögren's Syndrome
Status: ACTIVE_NOT_RECRUITING
Conditions: Primary Sjögren's Syndrome
Interventions: BIOLOGICAL: Efgartigimod
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessing the Analgesic Efficacy of Naproxen Sodium in Postsurgical Dental Pain.
Status: COMPLETED
Conditions: Toothache
Interventions: DRUG: Naproxen Sodium ER (BAYH6689)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Cast vs. Splints for Minimally Displaced Distal Radius Fractures in the Elderly
Status: COMPLETED
Conditions: Radius; Fracture, Lower or Distal End
Interventions: DEVICE: Cast made of generic plaster or fiberglass cast material|DEVICE: Generic "off the shelf" removable splint
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Feasibility Open Label Study Evaluating The Use Of Process-Instructed Self Neuro-Modulation (PRISM) For Post-Traumatic Stress Disorder
Status: WITHDRAWN
Conditions: Post-traumatic Stress Disorder
Interventions: DEVICE: PROCESS-INSTRUCTED SELF NEURO-MODULATION (PRISM)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Pharmacokinetics of IA and IV Ga68-PSMA-11 Infusion
Status: COMPLETED
Conditions: Prostate Adenocarcinoma|Prostate Carcinoma|Stage IIC Prostate Cancer AJCC v8|Stage III Prostate Cancer AJCC v8|Stage IIIA Prostate Cancer AJCC v8|Stage IIIB Prostate Cancer AJCC v8|Stage IIIC Prostate Cancer AJCC v8|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8
Interventions: PROCEDURE: Angiogram|PROCEDURE: Catheterization|DRUG: Gallium Ga-labeled PSMA-11|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Radio-immunotherapy (RIT) for Patients With Relapse or Refractory Acute Lymphoblastic Leukaemia (ALL) B CD22+
Status: UNKNOWN
Conditions: Acute Lymphoblastic Leukemia
Interventions: DRUG: Epratuzumab and 90Y-Epratuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Efficacy of Lastacaft® Compared to Pataday™ and Placebo in Patients With Acute Allergic Conjunctivitis
Status: COMPLETED
Conditions: Conjunctivitis, Allergic
Interventions: DRUG: Alcaftadine 0.25%|DRUG: Olopatadine 0.2%|DRUG: dextran 70 0.1%/hydroxypropyl methylcellulose 0.3%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Gemtuzumab Ozogamicin Therapy in DNA Samples From Patients With Acute Myeloid Leukemia Treated on COG-AAML0531
Status: COMPLETED
Conditions: Leukemia
Interventions: GENETIC: DNA analysis|GENETIC: gene expression analysis|OTHER: laboratory biomarker analysis|OTHER: pharmacogenomic studies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Asthma Clinical Research Network (ACRN) Trial - Best Adjustment Strategy for Asthma in Long Term (BASALT)
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Symptom-based adjustment|BEHAVIORAL: Biomarker-based adjustment|BEHAVIORAL: Guideline-based adjustment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex
Status: COMPLETED
Conditions: AIDS Dementia Complex|HIV Infections
Interventions: DRUG: Zidovudine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Medical Economic Evaluation of Bilateral Allograft of Hands and Forearms
Status: RECRUITING
Conditions: Bilateral Traumatic Amputation of Upper Limbs
Interventions: PROCEDURE: Bilateral allograft of the hands and forearms.|PROCEDURE: Prosthetic forehands
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Multimedia Toolkits to Implement 12-Step Recovery Concepts in Group Counseling
Status: COMPLETED
Conditions: Alcohol Abuse|Drug Abuse
Interventions: BEHAVIORAL: Multimedia 12-Step Toolkit|BEHAVIORAL: Treatment as Usual
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Challenge Study to Assess the Protective Efficacy of Two Malaria Vaccine Candidates
Status: COMPLETED
Conditions: Plasmodium Falciparum Malaria
Interventions: BIOLOGICAL: ChAd63-MVA CS|BIOLOGICAL: ChAd63-MVA ME-TRAP|OTHER: Controlled Human Malaria Infection Administered by Mosquito Bite
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout
Status: COMPLETED
Conditions: Gout
Interventions: BIOLOGICAL: Pegloticase
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Chemoradiotherapy With SHR-1316 For Treatment of Locally Advanced Cervical Cancer
Status: RECRUITING
Conditions: Locally Advanced Cervical Cancer
Interventions: BIOLOGICAL: SHR-1316|DRUG: Cisplatin Injection/Carboplatin Injection|RADIATION: External Beam Radiotherapy (EBRT)/Brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Non Invasive Ventilation Combined to High Flow Nasal Cannula Oxygen for Preoxygenation of Hypoxemic ICU Patients
Status: COMPLETED
Conditions: Intubation Intraesophageal
Interventions: DEVICE: Non invasive ventilation + High flow nasal cannula oxygen|DEVICE: Non invasive ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: An Investigation to Evaluate the Function of a New Silicon Cover Film and an On-top Suction Device to be Used in a NPWT System in the Treatment of Acute and Chronic Wounds
Status: COMPLETED
Conditions: Acute and Chronic Wounds
Interventions: DEVICE: External Suction Interface and a Silicon Film
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
Status: COMPLETED
Conditions: Cervical Spinal Cord Injury|Spine Injury|Spinal Cord Trauma
Interventions: BIOLOGICAL: AST-OPC1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Manual Therapy on Psychological Factors and Quality of Life in Lumbal Disc Herniation Patients
Status: COMPLETED
Conditions: Intervertebral Disc Displacement|Lumbar Disc Herniation|Psychological|Quality of Life
Interventions: BEHAVIORAL: Manual Therapy|BEHAVIORAL: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy Volunteers
Status: COMPLETED
Conditions: Hyperhomocysteinemia
Interventions: DRUG: TEST 1|DRUG: TEST 2|DRUG: TEST 3|DRUG: TEST 4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Nabilone for Agitation Blinded Intervention Trial
Status: RECRUITING
Conditions: Alzheimer Disease|Agitation
Interventions: DRUG: Nabilone|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Ranging Study of Alfuzosin in Patients With Lower Urinary Tract Symptoms Related to Benign Prostatic Hyperplasia
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia
Interventions: DRUG: SL77.0499-10 (alfuzosin hydrochloride)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: High Flow Nasal Oxygen and Acute Left Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Noninvasive Ventilation|Oxygen Therapy
Interventions: DEVICE: High Flow Nasal Oxygen|DEVICE: Non-invasive Ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Purple Wheat Consumption on Markers of Inflammation and Oxidative Stress in Adults.
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Purple Wheat Convenience Bars|OTHER: Control Wheat Convenience Bars
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Gefitinib, Paclitaxel, and Radiation Therapy in Treating Patients With Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: DRUG: gefitinib|DRUG: paclitaxel|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Influence of the Autonomic Nervous System in Response to Exercise in Hypertensive Individuals
Status: UNKNOWN
Conditions: Autonomic Nervous System|Hypertension
Interventions: DRUG: α1-adrenergic block|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Endoscopic Resection Multicenter Registry
Status: UNKNOWN
Conditions: Gastrointestinal Neoplasms|Gastrointestinal Disease|Gastric Cancer|Gastric Neoplasm|Gastric Polyp|Esophageal Neoplasms|Duodenal Neoplasms|Duodenal Polyp|Stomach Neoplasm|Stomach Polyp|Neoplasms|Colon Polyp|Colon Neoplasm
Interventions: PROCEDURE: Endoscopic Resection
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Sonoelastography of the Supraspinatus Tendon
Status: COMPLETED
Conditions: Elasticity Imaging Techniques|Tendinopathy|Rotator Cuff Tendinitis|Musculoskeletal Disease
Interventions: OTHER: Low Load Exercises
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Platelet -Rich Plasma (PRP) Injection for the Treatment of Severe Dry Eye
Status: COMPLETED
Conditions: Dry Eye|Sjogren Syndrome
Interventions: DRUG: PRP injection|DRUG: Standard care Hyaluronic acid eye drops
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: COVID-19 Convalescent Plasma for the Treatment of Hospitalized Patients With Pneumonia Caused by SARS-CoV-2.
Status: COMPLETED
Conditions: COVID-19
Interventions: BIOLOGICAL: COVID-19 Convalescent Plasma
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preventive Inhalation of Hypertonic Saline in Infants With Cystic Fibrosis
Status: COMPLETED
Conditions: Cystic Fibrosis Lung Disease
Interventions: DRUG: 6% Hypertonic Saline (HS), 4mL|DRUG: 0.9% Isotonic Saline (IS), 4mL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Outcomes Following Suction Drain and Non-suction Drain Assisted Total Knee Arthroplasty
Status: COMPLETED
Conditions: Osteoarthritis|Bilateral Total Knee Arthroplasty
Interventions: PROCEDURE: Drain|PROCEDURE: No Drain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus
Status: RECRUITING
Conditions: Generalized Convulsive Status Epilepticus
Interventions: DRUG: Ketamine|DRUG: Midazolam|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Gefitinib, Trastuzumab, and Docetaxel in Treating Patients With Metastatic Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: docetaxel|DRUG: gefitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Kinesiology Taping Effectiveness in the Treatment of Lumbar Spine Pain
Status: COMPLETED
Conditions: Low Back Pain|Young Adult|Therapy
Interventions: OTHER: Dynamic tape|OTHER: Sham tape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clarification of Abatacept Effects in SLE With Integrated Biologic and Clinical Approaches
Status: COMPLETED
Conditions: Systemic Lupus Erythematosus
Interventions: BIOLOGICAL: Abatacept|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Influence of Radiofrequency-based Toothbrush on the Accumulation of Calculus
Status: COMPLETED
Conditions: Oral Hygiene
Interventions: DEVICE: Silk'n Toothwave
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Incidence of Cancer in Women at Increased Genetic Risk of Ovarian Cancer
Status: COMPLETED
Conditions: Breast Carcinoma|Fallopian Tube Carcinoma|Ovarian Neoplasm|Primary Peritoneal Carcinoma
Interventions: PROCEDURE: Evaluation of Cancer Risk Factors|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|PROCEDURE: Study of High Risk Factors
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival
Status: COMPLETED
Conditions: Corneal Neovascularization|Corneal Graft Failure
Interventions: DRUG: Avastin® (bevacizumab)|DRUG: 0.9% NaCl & Refresh Liquigel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Effect of GW870086X on Allergen Challenge in Mild Asthmatics
Status: COMPLETED
Conditions: Asthma
Interventions: DRUG: GW870086X|DRUG: FP|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Continuous and Burst High Frequency Spinal Cord Stimulation Paradigms
Status: WITHDRAWN
Conditions: Chronic Low-back Pain|CRPS|Peripheral Neuropathy
Interventions: DEVICE: Intermittent Dosing HF10 30/90|DEVICE: Intermittent Dosing HF10 30/360
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Carboplatin and Paclitaxel With or Without Cisplatin and Radiation Therapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IVA Endometrial Cancer
Status: UNKNOWN
Conditions: Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Stage IA Uterine Corpus Cancer AJCC v7|Stage IB Uterine Corpus Cancer AJCC v7|Stage II Uterine Corpus Cancer AJCC v7|Stage IIIA Uterine Corpus Cancer AJCC v7|Stage IIIB Uterine Corpus Cancer AJCC v7|Stage IIIC Uterine Corpus Cancer AJCC v7|Stage IVA Uterine Corpus Cancer AJCC v7
Interventions: DRUG: Carboplatin|DRUG: Cisplatin|RADIATION: Internal Radiation Therapy|DRUG: Paclitaxel|OTHER: Quality-of-Life Assessment|RADIATION: Radiation Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lapatinib and Tamoxifen in Treating Patients With Locally Advanced or Metastatic Breast Cancer That Did Not Respond to Previous Tamoxifen
Status: COMPLETED
Conditions: Estrogen Receptor Positive|Male Breast Carcinoma|Progesterone Receptor Positive|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: OTHER: Laboratory Biomarker Analysis|DRUG: Lapatinib Ditosylate|DRUG: Tamoxifen Citrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Isavuconazole Following a Single Dose of Isavuconazonium Sulfate Intravenous Solution Via Nasogastric (NG) Tube Compared to a Single Dose of Oral Capsules Under Fasting Conditions in Healthy Participants
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Isavuconazonium sulfate IV|DRUG: Isavuconazonium sulfate capsules
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel Disease
Status: COMPLETED
Conditions: Pyoderma Gangrenosum|Crohn's Disease|Ulcerative Colitis|Inflammatory Bowel Disease
Interventions: DRUG: Infliximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study of Genetic Testing Uptake Through Enhanced Oncology Nurse-Led Intervention
Status: NOT_YET_RECRUITING
Conditions: Solid Tumor, Adult
Interventions: OTHER: Enhanced education|OTHER: Usual care education
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: WalkAide Compared to Ankle-Foot Orthosis (AFO) in Stroke Patients
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: WalkAide|OTHER: Ankle-Foot Orthosis (AFO)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of MP0533 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
Status: RECRUITING
Conditions: Leukemia|Relapsed|Myeloid|Acute
Interventions: DRUG: MP0533 (multispecific DARPin CD3 Engager Targeting CD33, CD123 and CD70)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Paraoxonase-1 Pseudo Cholinesterase Organophosphate Toxicity Enzyme in Prediction the Severity and Outcome of Acute Organophosphate Poisoning and Its Correlation With Pseudo Cholinesterase Enzyme Level.
Status: NOT_YET_RECRUITING
Conditions: Organophosphate Poisoning
Interventions: DIAGNOSTIC_TEST: Serum Pararoxonase -1 level|DIAGNOSTIC_TEST: Diagnostic Test: Serum pseudocholinesterase enzyme level
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study to Investigate Adherence of Patients to Clodronate (Bonefos) Treatment
Status: COMPLETED
Conditions: Breast Neoplasms|Prostatic Neoplasms|Multiple Myeloma|Osteolysis
Interventions: DRUG: Clodronate (Bonefos, BAY94-8393)
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL
Status: RECRUITING
Conditions: Lymphoma|Immune System Diseases|Immunoproliferative Disorders|Lymphatic Diseases|Lymphoproliferative Disorders|Neoplasms|Cutaneous Lymphoma|Cutaneous Anaplastic Large Cell Lymphoma|Mycosis Fungoides|Sezary Syndrome|Lymphomatoid Papulosis|Cutaneous T Cell Lymphoma|Gray Zone Lymphoma
Interventions: BIOLOGICAL: ATLCAR.CD30.CCR4 cells|BIOLOGICAL: ALTCAR.CD30 cells|DRUG: Bendamustine|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase I, Multicenter, Dose Escalation Study of CAT-8015 in Participants With Chronic Leukemia
Status: TERMINATED
Conditions: Leukemia, Lymphoma, Chronic Lymphocytic|Leukemia, Prolymphocytic Leukemia, Small|Lymphocytic Lymphoma, Moxetumomab Pasudotox
Interventions: DRUG: CAT-8015 5 mcg/kg|DRUG: CAT-8015 10 mcg/kg|DRUG: CAT-8015 20 mcg/kg
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Open Label Positron Emission Tomography (PET) Study of GSK618334 in Healthy Male Subjects Using 11C-PHNO as PET Ligand
Status: COMPLETED
Conditions: Substance Dependence
Interventions: DRUG: GSK618334
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata
Status: COMPLETED
Conditions: Uterine Fibroids
Interventions: DRUG: PGL4001, placebo|DRUG: PGL4001, progestin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Disturbance of the Intestinal Microbiota by Temocillin vs Cefotaxime in Treatment of Febrile Urinary Tract Infections
Status: COMPLETED
Conditions: Urinary Tract Infections
Interventions: DRUG: Temocillin|DRUG: Cefotaxime
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ranibizumab and Bevacizumab for Diabetic Macular Edema
Status: COMPLETED
Conditions: Diabetic Macular Edema
Interventions: DRUG: Ranibizumab|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of GLUCUBE Performance, a Non-invasive System for Monitoring Blood Glucose Levels Based on Near Infrared Spectroscopy (NIRS) Technology.
Status: RECRUITING
Conditions: Blood Glucose
Interventions: DEVICE: GLUCUBE device
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Safety, Tolerability & Pharmacokinetics Study of CNTX-6016 in Healthy Subjects and Subjects With PDN
Status: COMPLETED
Conditions: Painful Diabetic Neuropathy
Interventions: DRUG: Oral dose CNTX-6016 or oral dose Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex
Status: COMPLETED
Conditions: Tuberous Sclerosis Complex
Interventions: DRUG: Early Vigabatrin|DRUG: Delayed Vigabatrin (Placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Y 90 Ibritumomab Tiuxetan &Rituximab Relapsed or Refractory Diffuse Large B-Cell Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: rituximab|DRUG: cytarabine|DRUG: liposomal cytarabine|RADIATION: yttrium Y 90 ibritumomab tiuxetan
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness and Safety of Lactobacillus Acidophilus LA85 in Preventing Antibiotic-Associated Diarrhea
Status: COMPLETED
Conditions: Antibiotic Side Effect|Probiotics|Diarrhea
Interventions: OTHER: Probiotic Lactobacillus acidophilus LA85
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study Designed to Compare 2 Dose Strengths of TI Inhalation Powder in Adults With Type 1 Diabetes Mellitus and to Compare One of Those Formulations (30Units) With an Injection of Insulin Lispro
Status: COMPLETED
Conditions: Diabetes Mellitus: Type 1
Interventions: DRUG: Technosphere® Insulin Inhalation Powder|DRUG: Technosphere Insulin® Inhalation Powder|DRUG: RAA Population
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Decitabine Combining Dexamethasone Versus Dexamethasone in Management of ITP
Status: UNKNOWN
Conditions: Purpura, Thrombocytopenic, Idiopathic|Immune Thrombocytopenia
Interventions: DRUG: Decitabine|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: tirofiban in PV|DRUG: tirofiban in IC|DRUG: antiplatelet thrombolysin|DRUG: placebo|DRUG: Clopidogrel|DRUG: Aspirin|DRUG: Clopidogrel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Tapered Warfarin or Interrupted Warfarin With Heparin Bridging for Pacemaker or Defibrillator Implantation
Status: TERMINATED
Conditions: Cardiac Arrhythmias|Hemorrhage|Thromboembolism
Interventions: DRUG: Tapered warfarin regimen|DRUG: Bridged regimen Low-molecular-weight heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pediatric Delirium
Status: RECRUITING
Conditions: Pediatric Delirium
Interventions: DRUG: Intra-nasal Dexmedetomidine|DRUG: Oral Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Specific Molecular Imaging of DX600 Labeled by PET Radionuclide Targeting ACE2 in Patients
Status: COMPLETED
Conditions: Solid Tumor
Interventions: OTHER: 68Ga-DX600 PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Molecular Markers in Predicting Lung Cancer Development Using Tissue Samples From Healthy Participants
Status: COMPLETED
Conditions: Healthy, no Evidence of Disease|Lung Cancer
Interventions: GENETIC: proteomic profiling|OTHER: biologic sample preservation procedure|OTHER: laboratory biomarker analysis|PROCEDURE: bronchoscopy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Myeloablative Haploidentical BMT With Post-transplant Cyclophosphamide for Pediatric Patients With Hematologic Malignancies
Status: COMPLETED
Conditions: Myeloablative Conditioning|HLA-mismatched Bone Marrow Transplantation|Graft Survival|Transplantation, Bone Marrow
Interventions: DRUG: Cyclophosphamide|RADIATION: TBI|DRUG: Busulfan|OTHER: Unmanipulated Bone Marrow|DRUG: Tacrolimus|DRUG: Mycophenolate mofetil
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED)
Status: COMPLETED
Conditions: Thyroid-Related Eye Disease
Interventions: DRUG: LIPO-102|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Study of Baricitinib and Ciclosporin in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Baricitinib|DRUG: Ciclosporin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Short and Long Outcomes Between Laparoscopic and Open Hepatectomy
Status: NOT_YET_RECRUITING
Conditions: Laparoscopic Liver Resection|Open Liver Resection
Interventions: PROCEDURE: Laparoscopic liver resection|PROCEDURE: Open liver resection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Hepatic Arterial Infusion With Intravenous Irinotecan, 5FU and Leucovorin With or Without Panitumumab, in Patients With Wild Type RAS Who Have Resected Hepatic Metastases From Colorectal Cancer
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: panitumumab|DRUG: Randomization to No Panitumumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of Scarclinic™ Thin in Surgical Scars
Status: COMPLETED
Conditions: Hypertrophic Surgical Scar
Interventions: DEVICE: Scarclinic™ Thin|DEVICE: Scarclinic™ Normal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation in Newly Diagnosed High-relapse-risk CEBPA Mutant Acute Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Chemotherapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Nasal Bridles and Repeat Endoscopic Procedures for Endoscopic Nasoenteric Tubes
Status: COMPLETED
Conditions: Feeding Disorders
Interventions: DEVICE: Nasal Bridle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Transoral Robotic Surgery (TORS) for Oral and Laryngopharyngeal Lesions Using Da Vinci Robotic Surgical System
Status: COMPLETED
Conditions: Head and Neck Neoplasms
Interventions: DEVICE: Da Vinci Robotic Transoral Robotic Surgical System
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study in Participants With Moderate to Severe Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: BIOLOGICAL: Ixekizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nurse-led Continuum of Care for People With Diabetes and Pre-diabetes in Nepal
Status: UNKNOWN
Conditions: Diabetes Mellitus, Type 2
Interventions: BEHAVIORAL: Nurse-led Continuum of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION