pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Iloprost for Bridging to Heart Transplantation in PH
Status: WITHDRAWN
Conditions: Chronic Left Ventricular Failure|Pulmonary Hypertension
Interventions: DRUG: Inhaled Iloprost|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diammine Silver Fluoride in Arresting Enamel Caries Lesions on Babies' Occlusal Surfaces
Status: UNKNOWN
Conditions: Dental Caries
Interventions: OTHER: Silver diamine fluoride|OTHER: Fluoride Varnish
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: (CHANT)Real World Study of Duvelisib in the Treatment of Non-Hodgkin's Lymphoma (NHL)
Status: NOT_YET_RECRUITING
Conditions: Follicular Lymphoma|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|Richter Syndrome|Marginal Zone Lymphoma|Peripheral T Cell Lymphoma|Diffuse Large B Cell Lymphoma
Interventions: DRUG: Duvelisib
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Multicener, Postmarketing Study Evaluating the Transfer of Cimzia From the Mother to the Infant Via the Placenta
Status: COMPLETED
Conditions: Axial Spondyloarthritis (AxSpA)|Non-radiographic Evidence-AxSpA|Ankylosing Spondylitis|Crohn's Disease|Psoriatic Arthritis|Rheumatoid Arthritis
Interventions: PROCEDURE: Blood sampling from mother|PROCEDURE: Blood sampling from infant|PROCEDURE: Blood sampling from umbilical cord|BIOLOGICAL: Certolizumab Pegol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Beet Root Supplement Trial
Status: COMPLETED
Conditions: Trained or Competitive Cyclists
Interventions: DIETARY_SUPPLEMENT: Beetroot juice|DIETARY_SUPPLEMENT: Beetroot powder|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Efficacy Study of TLL018 in the Treatment of Ulcerative Colitis
Status: WITHDRAWN
Conditions: Ulcerative Colitis
Interventions: DRUG: TLL018|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain Energy Metabolism and Sleep in Adults
Status: TERMINATED
Conditions: Alzheimer Disease|Mild Cognitive Impairment|Cognitive Change|Energy Metabolism|Sleep Disturbance
Interventions: DEVICE: MyTAP oral appliance plus mouth shield
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Transverse Abdominis Plane (TAP) Block After Cesarean Delivery
Status: COMPLETED
Conditions: Postoperative Pain|Pregnancy|Obesity
Interventions: DRUG: 0.9% Normal Saline|DRUG: 0.2% Ropivacaine|DRUG: 0.5% Ropivacaine|DRUG: 0.75% Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Anticoagulation For Pulmonary Hypertension in Sickle Cell Disease
Status: TERMINATED
Conditions: Pulmonary Hypertension
Interventions: DRUG: Warfarin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Ecosystem Focused Therapy in Post Stroke Depression
Status: COMPLETED
Conditions: Depression|Stroke
Interventions: BEHAVIORAL: Education on Stroke and Depression (ESD)|BEHAVIORAL: Ecosystem Focused Therapy (EFT)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Carnitine Infusion and Insulin Resistance
Status: TERMINATED
Conditions: Glucose Intolerance
Interventions: DRUG: Carnitor|DIETARY_SUPPLEMENT: IntraLipid|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Observational Study of Effectiveness and Safety of Trastuzumab Emtansine (T-DM1) in HER2-positive Breast Cancer Patients With Residual Invasive Disease Following Neoadjuvant Chemotherapy and Anti-HER2 Target Therapy
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Trastuzumab emtansine
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety of BCD-100 (Anti-PD-1) in Combination With Platinum-Based Chemotherapy and Bevacizumab in Patients With Recurrent, Persistent or Metastatic Cervical Cancer (CAESURA)
Status: UNKNOWN
Conditions: Cervical Cancer|Cervical Cancer Metastatic|Cervical Cancer Recurrent
Interventions: BIOLOGICAL: BCD-100|BIOLOGICAL: Bevacizumab|DRUG: Paclitaxel|DRUG: Cisplatin (or carboplatin)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alvespimycin Hydrochloride in Treating Patients With Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-Cell Prolymphocytic Leukemia
Status: TERMINATED
Conditions: B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Small Lymphocytic Lymphoma|Refractory Chronic Lymphocytic Leukemia
Interventions: DRUG: alvespimycin hydrochloride|OTHER: diagnostic laboratory biomarker analysis|OTHER: pharmacogenomic studies|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) as a Booster
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|SARS-CoV-2 Infection
Interventions: BIOLOGICAL: Recombinant COVID-19 variant Vaccine (Sf9 Cell)|BIOLOGICAL: COVID-19 Vaccine (Vero Cell), Inactivated|BIOLOGICAL: mRNA COVID-19 vaccine (Moderna)|BIOLOGICAL: Viral Vector COVID-19 vaccine (AstraZeneca)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Accurate DCE-MRI Measurement of Glioblastoma Using Point-of-care Portable Perfusion Phantom
Status: ACTIVE_NOT_RECRUITING
Conditions: Glioblastoma
Interventions: DEVICE: Point-of-care Portable Perfusion Phantom (P4)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Toddler Milk Intervention Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Young-child formula with low protein content|DIETARY_SUPPLEMENT: Young-child formula with protein content similar to that of cow's milk
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Supercharged TRAM Evaluation in Cervical Esophagogastroplasty After Esophagectomy
Status: RECRUITING
Conditions: Esophagus Cancer|Carcinoma Esophagus
Interventions: PROCEDURE: Supercharged TRAM esophagectomy|PROCEDURE: Conventional Esophagectomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Mobile Web-Based Parenting Intervention to Strengthen Social-Emotional Development of Low Birth Weight Infants
Status: COMPLETED
Conditions: Intensive Care Units Neonatal|Parenting|Infant Health
Interventions: BEHAVIORAL: NICU Mom and Baby Net|OTHER: NICU Developmental Awareness System
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety Study of IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) or Soft Tissue Sarcomas (STS)
Status: COMPLETED
Conditions: Gastrointestinal Stromal Tumors|Soft Tissue Sarcomas
Interventions: DRUG: IPI-504
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy
Status: RECRUITING
Conditions: Rectal Cancer|Comorbidities and Coexisting Conditions|Inoperable Disease|Brachytherapy
Interventions: RADIATION: External beam radiotherapy + Endorectal brachytherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair
Status: COMPLETED
Conditions: Graft Versus Host Disease|Hyperkalemia|Craniectomy|Synostectomy|FOA|Congenital Malformations
Interventions: OTHER: Irradiated Blood Transfusions|OTHER: Non-Irradiated Blood Transfusions
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: DLBS2411 Treatment For Functional Dyspepsia
Status: RECRUITING
Conditions: Functional Dyspepsia
Interventions: DRUG: Placebo caplet of DLBS2411|DRUG: DLBS2411
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of the Quell Wearable Device for Chronic Overlapping Pain Conditions
Status: RECRUITING
Conditions: Chronic Pain|Adults 21 and Older|Multiple Chronic Overlapping Pain Conditions|Hypersensitivity
Interventions: DEVICE: High Intensity Quell|DEVICE: Low Intensity Quell
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Language-based Learning Skills and Attention Deficit Hyperactivity Disorder (ADHD): Impact of Treatment With Sustained-release Guanfacine
Status: COMPLETED
Conditions: Attention-deficit/Hyperactivity Disorder
Interventions: DRUG: Guanfacine (sustained release)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dengue 4 Human Infection Model (Dengue CVD 11000; DHIM-4)
Status: COMPLETED
Conditions: Dengue
Interventions: BIOLOGICAL: Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - Low Dose|BIOLOGICAL: Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - Medium Dose|BIOLOGICAL: Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - High Dose
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Oral Glyceryl Triacetate (GTA) in Newborns With Canavan
Status: UNKNOWN
Conditions: Canavan Disease
Interventions: DIETARY_SUPPLEMENT: GTA (Glyceryl triacetate)|DRUG: GTA glyceryl triacetate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Personalizing Sleep Interventions to Prevent Type 2 Diabetes in Community Dwelling Adults With Pre-Diabetes
Status: UNKNOWN
Conditions: PreDiabetes
Interventions: BEHAVIORAL: Sleep extension|OTHER: Habitual sleep
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: Fire Fighter Fatigue Management Program: Operation Fight Fatigue
Status: COMPLETED
Conditions: Shift-Work Sleep Disorder|Insomnia|Restless Leg Syndrome|Obstructive Sleep Apnea|Impaired Driving
Interventions: BEHAVIORAL: Sleep health education provided via a web-based program|OTHER: Sleep disorder detection and treatment|OTHER: Optimization of Sleep in Fire Station
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
Status: COMPLETED
Conditions: Aging, Premature|Congenital Heart Disease|White Matter Hyperintensities
Interventions: OTHER: Brain MRI|OTHER: Neuropsychological test battery
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate the Efficacy and Safety of PPB-R-203-Based Meal Versus TK9-Based Meal in 20 Patients With Diabetes
Status: UNKNOWN
Conditions: Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: PPB-R-203-Based Meal|DIETARY_SUPPLEMENT: TK9-Based Meal
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy
Status: TERMINATED
Conditions: Intrauterine Adhesions
Interventions: DEVICE: Seprafilm|DEVICE: Sterile Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Digimeds to Optimize Adherence in Patients With Hepatitis C and Increased Risk for Nonadherence
Status: UNKNOWN
Conditions: Hepatitis C, Chronic|Nonadherence, Patient
Interventions: DEVICE: Digital Medicine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed the Relevant Parent Studies.
Status: ACTIVE_NOT_RECRUITING
Conditions: Fibrodysplasia Ossificans Progressiva (FOP)
Interventions: DRUG: Palovarotene
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Allergen Immunotherapy on Anti-viral Immunity in Patients With Allergic Asthma
Status: COMPLETED
Conditions: Allergic Asthma Due to Dermatophagoides Pteronyssinus
Interventions: DRUG: ODACTRA 12 SQ-HDM Sublingual Tablet|DRUG: Placebo sublingual tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Characterize Flu-like Symptoms in Relapsing Multiple Sclerosis Patients Transitioning From Non-Pegylated Interferon Beta (IFN-β) Therapies to Peginterferon Beta-1a (BIIB017)
Status: COMPLETED
Conditions: Relapsing Multiple Sclerosis
Interventions: DRUG: BIIB017|DRUG: naproxen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures
Status: COMPLETED
Conditions: Femur Fracture|Tibial Fractures
Interventions: OTHER: Use of non-steroid anti-inflammatory drugs (NSAIDS) as an alternative for post-operative pain management after a femur and tibia fracture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Acute Impact of Yoga-based Stretching on Inflammation and Its Resolution
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammation|Fascia; Inflammation|Musculoskeletal Pain|Lower Back Pain|Neck Pain
Interventions: PROCEDURE: Yoga-based stretching
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quality of Life in African-American or Caucasian Female Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer|Cancer Survivor|Depression|Fatigue|Sexual Dysfunction|Sleep Disorders|Spiritual Concerns
Interventions: OTHER: study of socioeconomic and demographic variables|PROCEDURE: fatigue assessment and management|PROCEDURE: management of therapy complications|PROCEDURE: psychosocial assessment and care|PROCEDURE: quality-of-life assessment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A RCT to Evaluate the Efficacy and Safety of Automated Needle Targeting (ANT-X) System Compared to Traditional Free Hand Puncture for Renal Access in Percutaneous Nephrolithotomy (PCNL)
Status: UNKNOWN
Conditions: Kidney Stone
Interventions: DEVICE: Renal Calyx punture with traditional free hand or ANT-X device
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sitravatinib and Nivolumab for the Treatment of Metastatic or Advanced Clear Cell Renal Cell Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Clear Cell Renal Cell Carcinoma|Metastatic Clear Cell Renal Cell Carcinoma|Stage IV Renal Cell Cancer AJCC v8
Interventions: BIOLOGICAL: Nivolumab|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Sitravatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Does Caffeine Facilitate Human Reward Learning Behaviors?
Status: RECRUITING
Conditions: Caffeine
Interventions: DIETARY_SUPPLEMENT: caffeine|DIETARY_SUPPLEMENT: mannitol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: TXV13-01 Estradiol Vaginal Softgel Capsules in Treating Postmenopausal Women With Symptoms of Vulvar and Vaginal Atrophy
Status: COMPLETED
Conditions: Menopause|Vulvovaginal Atrophy|Painful Intercourse|Dyspareunia
Interventions: DRUG: Estradiol|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Chemoembolization of the Liver With or Without Sunitinib Malate in Treating Patients With Liver Cancer
Status: COMPLETED
Conditions: Liver Cancer
Interventions: DRUG: sunitinib malate|DRUG: Placebo|PROCEDURE: transarterial chemoembolization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CRLX101 (NLG207) in the Treatment of Advanced Solid Tumors
Status: COMPLETED
Conditions: Cancer|Solid Tumor
Interventions: DRUG: Camptothecin (CPT) conjugated to a linear, cyclodextrin-based polymer
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hybrid Versus Norwood Management Strategies in Infants Undergoing Single Ventricle Palliation
Status: UNKNOWN
Conditions: Congenital Heart Disease
Interventions: PROCEDURE: Norwood management strategy|PROCEDURE: Hybrid Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib in Patients With Advanced Penile Squamous Cell Carcinoma (PSCC) (CaboPen)
Status: UNKNOWN
Conditions: Penile Squamous Cell Carcinoma
Interventions: DRUG: Cabozantinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of 1.25 mmol/L Calcium Dialysate on Mineral Metabolism in Haemodialysis Patients.
Status: COMPLETED
Conditions: Hyperparathyroidism|Hypercalcemia
Interventions: DRUG: physiological (1.25 mmol/L ) calcium dialysate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption
Status: WITHDRAWN
Conditions: Opioid Use|Opioid Dependence|Knee Pain Chronic|Knee Osteoarthritis
Interventions: DRUG: Improved Opioid-Tapering Instructions|BEHAVIORAL: Clinical Patient Educator
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Telemedicine Home Assessments for Identification and Reduction of Asthma Triggers
Status: COMPLETED
Conditions: Asthma in Children
Interventions: BEHAVIORAL: Standard of Care Education|OTHER: Interactive Video (IAV) Telemedicine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Prospective Validation of the Emergency Heart Failure Mortality Risk Grade (EHMRG) Score in Patients With Acute Heart Failure in the Emergency Department
Status: COMPLETED
Conditions: Heart Failure|Heart Diseases|Acute Heart Failure
Interventions: OTHER: Investigation of the diagnostic accuracy of EHMRG risk score in patients with acute heart failure
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Hypoactive Delirium and Outcome Measures
Status: UNKNOWN
Conditions: Hypoactive Delirium
Interventions: DRUG: Haloperidol|OTHER: Placebo|OTHER: non-pharmacologic measures
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts
Status: WITHDRAWN
Conditions: Cocaine Dependence
Interventions: DRUG: Disulfiram|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Niraparib + Dostarlimab + RT in Pancreatic Cancer
Status: COMPLETED
Conditions: Pancreatic Cancer|Metastatic Pancreatic Cancer
Interventions: DRUG: Niraparib|DRUG: Dostarlimab|RADIATION: Radiation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma
Status: UNKNOWN
Conditions: Open Angle Glaucoma
Interventions: DEVICE: Goldmann tonometer|DEVICE: Pneumatonometer|DEVICE: Tonopen XL|DEVICE: ICare rebound tonometer
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Comparison of the Increment of Neuromuscular Parameters in Vegetarians and Non-vegetarians
Status: COMPLETED
Conditions: Strength Training|Dietary Proteins|Muscle Strength|Hypertrophy
Interventions: OTHER: Strength training|OTHER: Protein intake
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: ACP in Older Patients With Multimorbidity: a Randomized Pilot
Status: UNKNOWN
Conditions: Advance Care Planning|Multimorbidity|Old Age; Debility|Health Economics|Quality of Life|Patient Empowerment|Patient Satisfaction
Interventions: BEHAVIORAL: Advance Care Planning interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Analgesic Effects of Extraoral Ultrasound Block of Mandibular Nerve for the Extraction of Lower Third Molars
Status: COMPLETED
Conditions: Molar|Impacted Teeth
Interventions: PROCEDURE: US guided block of mandibular nerve|PROCEDURE: Intraoral block of lower alveolar nerve
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of DWJ1252 in the Treatment of Functional Dyspepsia (PART 2)
Status: COMPLETED
Conditions: Functional Dyspepsia
Interventions: DRUG: DWJ1252|DRUG: Gasmotin|DRUG: Placebo of Gasmotin|DRUG: Placebo of DWJ1252
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacies of Entecavir Add on HBeAg Negative Patients With HBV DNA Positive During Peginterferon Alpha 2a Treatment
Status: UNKNOWN
Conditions: Chronic Hepatitis B
Interventions: DRUG: Entecavir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Solanezumab (LY2062430) in Participants With Prodromal Alzheimer's Disease
Status: TERMINATED
Conditions: Alzheimer's Disease
Interventions: DRUG: Solanezumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors
Status: RECRUITING
Conditions: Neuroblastoma
Interventions: DRUG: Topotecan|DRUG: Temozolomide|DRUG: Ribociclib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single and Repeated Dosing Study to Assess the Safety and the Concentration-time Profile of SAR228810 in Alzheimer's Patients
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: SAR228810|DRUG: SAR228810
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: (HALT) Embrace Hydrogel Embolic System (HES) Study of Embolization in Peripheral Arterial Bleeds
Status: RECRUITING
Conditions: Arterial Bleeding in Solid Organs and Peripheral Arteries
Interventions: DEVICE: Embrace HES including Instylla™ Delivery Kit and Instylla™ Microcatheter
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Trial With TMC278-TIDP6-C222 for Continued TMC278 Access in Patients Infected With Human Immunodeficiency Virus-1
Status: COMPLETED
Conditions: HIV-1 Infection
Interventions: DRUG: Rilpivirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Relapsed and/or Chemotherapy Refractory CD33 Positive Acute Myeloid Leukemia by CART-33
Status: UNKNOWN
Conditions: Relapsed Adult Myeloid Leukemia|Chemotherapy Refractory Adult Myeloid Leukemia
Interventions: BIOLOGICAL: CART33 cells|BIOLOGICAL: anti-CD33 CART|BIOLOGICAL: anti-CD33 CAR T cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Alloreactive Haploidentical Natural Killer (NK) Cells With Busulfan and Fludarabine/ATG
Status: COMPLETED
Conditions: Leukemia|Chronic Myelogenous Leukemia
Interventions: DRUG: Fludarabine|DRUG: Busulfan|PROCEDURE: NK cell infusion:|DRUG: Interleukin-2|DRUG: Anti-Thymocyte Globulin|PROCEDURE: Allogeneic related Stem Cell Transplant|DRUG: Tacrolimus|DRUG: Methotrexate|DRUG: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Control Following Sinus Surgery
Status: COMPLETED
Conditions: Sinusitis|Opioid Use|Opioid Abuse|Narcotic Use|Otolaryngologic Disease|Postoperative Pain|Pain
Interventions: DRUG: OxyCODONE 5 Mg (milligram) Oral Tablet|DRUG: Ibuprofen 600 Mg (milligram) Oral Tablet|DRUG: Acetaminophen 650 MG (milligram) Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Improvement With Aripiprazole (Abilify) in Patients With Schizophrenia (BMS)
Status: TERMINATED
Conditions: Schizophrenia|Schizoaffective Disorder
Interventions: DRUG: aripiprazole
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Calcium Dobesilate Versus Coasting for Prevention of Ovarian Hyperstimulation Syndrome
Status: COMPLETED
Conditions: Infertility
Interventions: DRUG: Calcium Dobesilate|OTHER: coasting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: A Safety and Pharmacokinetic Study of Complarate (Tocilizumab Biosimilar) and Actemra® in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: Complarate®|BIOLOGICAL: Actemra®
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Ultrasound and Withdrawal of Biological DMARDs in Rheumatoid Arthritis
Status: TERMINATED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: bDMARD withdrawal (etanercept, adalimumab, infliximab, certolizumab, golimumab, tozilizumab, abatacept)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safe Drug Use in People With Intellectual and/or Developmental Disabilities - it Applies to Life
Status: ACTIVE_NOT_RECRUITING
Conditions: Disabilities, Intellectual|Disability, Developmental
Interventions: OTHER: Develop and implement the Framework for safe drug use in people with intellectual and/or developmental disabilities
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Reducing Blood Loss During Cesarean Myomectomy With Tranexamic Acid
Status: COMPLETED
Conditions: Cesarean Section Complications
Interventions: DRUG: IV tranexamic acid
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Randomized Clinical Trial of Nasal Turbinate Reduction to Improve Continuous Positive Airway Pressure (CPAP) Outcomes for Sleep Apnea
Status: COMPLETED
Conditions: Sleep Apnea Syndromes|Nasal Obstruction|Turbinate Hypertrophy
Interventions: PROCEDURE: Radiofrequency Turbinate Reduction|PROCEDURE: Sham RF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: All Polyethylene Tibia-VEGA Kiel
Status: COMPLETED
Conditions: Degenerative Osteoarthritis|Rheumatoid Arthritis|Post-traumatic; Arthrosis|Other Instability, Knee|Stiffness of Knee, Not Elsewhere Classified|Deformity of Knee Joint
Interventions: DEVICE: All-Poly
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Ezetimibe With Simvastatin in the Therapy of Adolescents With HeFH (Study P02579)
Status: COMPLETED
Conditions: Hypercholesterolemia
Interventions: DRUG: ezetimibe with simvastatin|DRUG: simvastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Dose Escalation, Safety and Pharmacokinetic Study of AVE8062 Combined With Docetaxel and Cisplatin in Patients With Solid Tumors
Status: COMPLETED
Conditions: Neoplasms, Malignant
Interventions: DRUG: OMBRABULIN (AVE8062)|DRUG: cisplatin|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of PF-03882845 In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: PF-03882845 or Placebo|DRUG: PF-03882845 or Placebo|DRUG: PF-03882845 or Placebo|DRUG: PF-03882845 or Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose:
Clinical trial: Fentanyl Pectin Nasal Spray (FNPS) for Exercise-Induced Breakthrough Dyspnea
Status: COMPLETED
Conditions: Advanced Cancers
Interventions: DRUG: Fentanyl Pectin Nasal Spray|DRUG: Placebo Nasal Spray|OTHER: Walk Test|BEHAVIORAL: Questionnaires|BEHAVIORAL: Mental Ability Tests
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Repurposing the Antipsychotic Drug Chlorpromazine as Adjuvant Therapeutic Agent for Resected Stage III Colon Cancer
Status: WITHDRAWN
Conditions: Colon Cancer Stage III
Interventions: DRUG: ChlorproMAZINE 50 MG|DRUG: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Family-Focused Psychoeducation in Treating Adolescents With Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder
Interventions: BEHAVIORAL: Family-focused therapy for adolescents|BEHAVIORAL: Enhanced care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
Status: UNKNOWN
Conditions: Septic Shock|Hemodynamic Instability|Vasoconstriction
Interventions: DRUG: Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: CRLX101(NLG207) in Combination With Bevacizumab for Metastatic Renal Cell Carcinoma (mRCC) Versus Standard of Care (SOC)
Status: COMPLETED
Conditions: Metastatic Renal Cell Carcinoma
Interventions: DRUG: CRLX101|DRUG: Bevacizumab|DRUG: Standard of Care (Investigator Choice)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity of an MF59-Adjuvanted Influenza Vaccine in Older Adults
Status: COMPLETED
Conditions: Influenza|Human
Interventions: BIOLOGICAL: Investigational aIIV4c|BIOLOGICAL: IIV4c|BIOLOGICAL: aIIV4|BIOLOGICAL: RIV4
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Safety and Tolerability of AAV8 Delivery of a Broadly Neutralizing Antibody in Adults Living With HIV: a Phase 1, Dose-escalation Trial
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV-1 Infected Adults With Controlled Viremia
Interventions: GENETIC: VRC-HIVAAV070-00-GT (AAV8-VRC07)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of New Predictors and Short Term Outcomes of Paravalvular Leakage After Transcatheter Aortic Valve Implanation
Status: UNKNOWN
Conditions: Paravalvular Leakage After TAVI
Interventions: DIAGNOSTIC_TEST: cardiac computed tomography and cardiac catheterization
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: FDG Tumor Heterogeneity During Chemoradiation as a Predictor of Response in Patients With Cervical Cancer
Status: TERMINATED
Conditions: Cervical Cancer|Uterine Cervical Cancer|Uterine Cervical Neoplasms
Interventions: DEVICE: FDG-PET/MR|DEVICE: FDG-PET/CT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Efficacy of Structured Exercise-Nutritional Intervention on Sarcopenia in Patients With Osteoporosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Sarcopenia|Osteoporosis
Interventions: DIETARY_SUPPLEMENT: β-hydroxy β-methylbutyrate (HMB)|BEHAVIORAL: Resistance, aerobic, flexibility and balance exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Alpha Lipoic Acid Effect on No-Reflow Phenomenon
Status: COMPLETED
Conditions: No-Reflow Phenomenon
Interventions: DIETARY_SUPPLEMENT: Alpha Lipoic Acid plus the standard care for post-PCI MI|DRUG: The standard care for post-PCI MI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease|Oxidative Stress|Dementia|Hyperlipidemia|Inflammation
Interventions: DIETARY_SUPPLEMENT: Fish Oil|DIETARY_SUPPLEMENT: Lipoic Acid|OTHER: Fish Oil Placebo|OTHER: Lipoic Acid Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Use of ABI-007 for the Prevention of Vascular Access Graft Failure in Patients Undergoing Hemodialysis
Status: TERMINATED
Conditions: Hemodialysis Graft Dysfunction
Interventions: DRUG: ABI-007
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Aim of This Study is to Determine the Incidence of Alterations in Fluorescent In Situ Hybridisation (FISH) of Spermatozoa and to Evaluate the Efficacy of the Use of Annexin Columns (MACS®) in Patients With Altered FISH Undergoing In Vitro Fertilisation Techniques
Status: COMPLETED
Conditions: Infertility, Male
Interventions: DEVICE: Magnetic Activated Cell Sorting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Performance of NivolisMonitor and NivolisAnton for Monitoring Patients on Ventilatory Assistance at Home
Status: ACTIVE_NOT_RECRUITING
Conditions: Respiratory Insufficiency|Respiratory Failure|Home Monitoring
Interventions: DEVICE: NivolisMonitor|DEVICE: NivolisAnton
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Study to Evaluate the Efficacy and Safety of Pirfenidone With Novel Coronavirus Infection
Status: UNKNOWN
Conditions: Novel Coronavirus Pneumonia|Pneumonia|Pirfenidone
Interventions: DRUG: pirfenidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiotherapy Led Community Intervention for Older Adults Discharged From the Emergency Department
Status: COMPLETED
Conditions: Old Age; Debility|Health Services for the Aged
Interventions: OTHER: Comprehensive Geriatric Assessment arm|OTHER: EDPLUS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The Efficacy of Balance and Proprioception Exercises in Patients With Knee Osteoarthritis
Status: COMPLETED
Conditions: Knee Osteoarthritis|Balance; Distorted|Proprioceptive Disorders
Interventions: OTHER: Balance and proprioception exercises|OTHER: Home exercises program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: KEBI-Cyto Study - Use of the Biocartis Idylla
Status: COMPLETED
Conditions: Pancreatic Adenocarcinoma|Lung Cancer
Interventions: DIAGNOSTIC_TEST: Biocartis Idylla platform - real time PCR detecting EGFR, KRAS and BRAF mutations in liquid based cytology and blood plasma samples
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Novel Biomarkers and Echocardiography for Subclinical Cardiac Toxicity in Breast Cancer Patients Receiving Anthracyclines
Status: UNKNOWN
Conditions: Cardiotoxicity|Heart Failure|Breast Cancer|Anthracycline Induced Cardiomyopathy|Biomarkers|Echocardiography
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Observational,Prospective Study to Develop and Validate a Prognostic Tool to Optimize Therapy in Patients With HCV G1/4
Status: COMPLETED
Conditions: Hepatitis C, Chronic
Interventions: DRUG: Peginterferon alfa-2a|DRUG: Ribavirin
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Contrast-enhanced Spectral Mammography (CESM) Early Quantitative Evaluation of Tumoral Response and Pathologic Complete Response Prediction for Localized Breast Cancer Treated by Neoadjuvant Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer
Interventions: DIAGNOSTIC_TEST: Diagnostic test
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Development and Validation of a Questionnaire to Measure the Impact of SBS and Its Treatments on Patients' Lives
Status: UNKNOWN
Conditions: SBS - Short Bowel Syndrome
Interventions: OTHER: Exploratory interviews|OTHER: Semi-directive interviews|OTHER: Delphi Process|OTHER: Think aloud interviews|OTHER: Psychometric validation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Predict H Trial
Status: COMPLETED
Conditions: Intraoperative Hypotension
Interventions: DEVICE: Hemosphere platform® together with the FloTrac Acumen IQ® sensor|DEVICE: Hemosphere platform® together with the FloTrac® sensor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of Soft Tissue Mobilization Technique and Piriformis Muscle Stretching Among Patients Having Piriformis Syndrome
Status: COMPLETED
Conditions: Piriformis Syndrome
Interventions: OTHER: Soft Tissue mobilization|OTHER: Piriformis Syndrome (Piriformis muscle stretching)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Efficacy Testing of a Culturally Relevant Stigma Intervention With WLWH in Tanzania
Status: ACTIVE_NOT_RECRUITING
Conditions: HIV|Stigma, Social|Self Efficacy|Self Esteem|Hope|Depressive Symptoms
Interventions: BEHAVIORAL: Labda Siku Moja stigma reduction intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications
Status: RECRUITING
Conditions: Diabetic Ketoacidosis
Interventions: DRUG: Insulin 0.05 IU/kg/h|DRUG: Insulin 0.10 IU/kg/h
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults
Status: COMPLETED
Conditions: Sleep
Interventions: BEHAVIORAL: ELDERFITNESS|OTHER: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy of Gemcitabine and Paclitaxel for Metastatic Breast Cancer
Status: COMPLETED
Conditions: Metastatic Breast Cancer
Interventions: DRUG: gemcitabine|DRUG: paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A)
Status: TERMINATED
Conditions: Dehydration
Interventions: DRUG: Subcutaneous HYLENEX (recombinant human hyaluronidase) and Lactated Ringer's solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lidocaine as Local Anesthetics in Children Under Ketamine Sedation
Status: UNKNOWN
Conditions: Conscious Sedation Failure During Procedure|Analgesia|Anesthesia
Interventions: DRUG: Lidocaine|DRUG: Normal saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Effect of Naltrexone on Lofexidine Single Dose Pharmacokinetics in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Lofexidine + Naltrexone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of GR1802 in Participants With Chronic Sinusitis With Nasal Polyps
Status: NOT_YET_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: DRUG: GR1802|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate Efficacy and Safety of HCP1401 for Stage 2 Hypertension Patients Not Controlled by HCP0605
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: HCP1401|DRUG: HCP0605
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Web-Based and Tailored Asthma Management Intervention (Puff City) in Teens With Asthma Attending Urban Clinics
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: Teens randomized to the experimental arm will receive 4 sessions plus a booster of web-based, tailored asthma management.|BEHAVIORAL: Teens in the control group will receive generic, web-based asthma education.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Lenalidomide and Decitabine in High Grade Myelodysplastic Syndromes
Status: COMPLETED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Lenalidomide, Decitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT