pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Non Hodgkin Lymphoma|Acute Lymphoblastic Leukemia|Diffuse Large B Cell Lymphoma|Primary Mediastinal Large B Cell Lymphoma|Mantle Cell Lymphoma|Follicular Lymphoma
Interventions: DRUG: TC-110 T Cells|DRUG: Fludarabine|DRUG: Cyclophosphamide
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Lonafarnib, Trastuzumab, and Paclitaxel in Treating Patients With HER2/Neu-Overexpressing Stage IIIB, Stage IIIC, or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: lonafarnib|DRUG: paclitaxel|OTHER: pharmacological study
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A 24 Month Phase 2a Open Label, Randomized Study of Avastin®, Lucentis®, or Eylea® (Anti-VEGF Therapy) Administered in Combination With Fovista® (Anti-PDGF BB Pegylated Aptamer)
Status: TERMINATED
Conditions: Age-Related Macular Degeneration
Interventions: DRUG: Fovista®|DRUG: bevacizumab|DRUG: ranibizumab|DRUG: aflibercept
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Kinesio Taping vs Jones Technique on Myofascial Trigger Points in Cervicalgia.
Status: COMPLETED
Conditions: Cervicalgia
Interventions: PROCEDURE: Jones technique|DEVICE: Kinesiotape
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of Single Platelet-Rich Plasma Local Injection Vs. Single Corticosteroid Local Injection in Carpal Tunnel Syndrome
Status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Interventions: DRUG: Local corticosteroid injection|DRUG: Platelet-rich Plasma Local injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: MARIGOLD Study: A Study of RO4917523 Versus Placebo as Adjunctive Therapy in Patients With Major Depressive Disorder and an Inadequate Response to Ongoing Antidepressant Therapy
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: Placebo|DRUG: RO4917523 0.5 mg|DRUG: RO4917523 1.5 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of an Online Educational Module Before Carrier Genetic Screening in Persons of Ashkenazi Jewish Descent.
Status: COMPLETED
Conditions: Tay Sachs Disease|Canavan Disease|Familial Dysautonomia
Interventions: OTHER: Online pre-test genetic education tool
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Cognitive Effects of Citicoline on Attention in Healthy Men and Women
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: Placebo supplement|DIETARY_SUPPLEMENT: Citicoline supplement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Dose Escalation Study of Long-acting ACTH Gel in Membranous Nephropathy
Status: COMPLETED
Conditions: Glomerulonephritis
Interventions: DRUG: Adrenocorticotrophic hormone ACTH
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study on the Performance of a Machine Learning Algorithm Recognizing and Triaging Large Vessel Occlusions Using Non-contrast CT Scans
Status: NOT_YET_RECRUITING
Conditions: Stroke, Ischemic|Stroke Hemorrhagic|Stroke, Acute|Brain Ischemia
Interventions: DEVICE: AI software for Stroke
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Expanded Clinical Study Evaluating the AAV2-RPE65 Gene Therapy(LX101) in Patients With LCA
Status: NOT_YET_RECRUITING
Conditions: To Evaluate the Scaling Clinical Study of AAV2-RPE65 Gene Therapy Agent (LX101) in Patients With Congenital Amaurosis (LCA)
Interventions: DRUG: LX101
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Bevacizumab Intravitreal Injections in the Treatment of Macular Edema Secondary to Retinal Vein Occlusion
Status: COMPLETED
Conditions: Macular Edema|Retinal Vein Occlusion
Interventions: DRUG: Avastin Intravitreal Injection|DRUG: Sham Avastin Intravitreal Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Dabrafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
Status: UNKNOWN
Conditions: Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled|Persistent Post Surgical Pain
Interventions: DIETARY_SUPPLEMENT: fractionated marine lipid concentrate derived from anchovy and sardine oil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Measurement of the Biting Force of Rabid Heat Cured Acrylic Resin Versus Modified Conventional Acrylic
Status: UNKNOWN
Conditions: Dental Anxiety
Interventions: OTHER: titanium dioxide denture base
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Extension Study of the Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy
Status: TERMINATED
Conditions: Diabetic Retinopathy
Interventions: DRUG: Octreotide acetate in microspheres
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Platelet Rich Fibrin in Soft Tissue Healing After Implant Uncovering
Status: COMPLETED
Conditions: Healing Surgical Wounds
Interventions: PROCEDURE: Application of L-PRF on the donor area|PROCEDURE: Secondary intention healing of the donor area
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Randomized, Open-label, Multi-center Phase IV Study Evaluating Palbociclib Plus Endocrine Treatment Versus a Chemotherapy-based Treatment Strategy in Patients With Hormone Receptor Positive / HER2 Negative Breast Cancer in a Real World Setting (GBG 93 - PADMA Study).
Status: UNKNOWN
Conditions: Metastatic Breast Cancer
Interventions: DRUG: Palbociclib / Chemotherapy (capecitabine, epirubicin, paclitaxel, vinorelbine) / Endocrine therapy (exemestane, fulvestrant, letrozole, tamoxifen)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Online Mindfulness-based Stress Reduction for Patients Receiving Chemotherapy
Status: NOT_YET_RECRUITING
Conditions: Breast Cancer|Stress
Interventions: OTHER: Online mindfulness-based stress reduction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: MEsenchymal StEm Cells for Multiple Sclerosis
Status: UNKNOWN
Conditions: Multiple Sclerosis
Interventions: BIOLOGICAL: Autologous Mesenchymal Stem Cells
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HGWD Improve the Paclitaxel-related Neurotoxicity in Patients With BC
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Huangqi Guizhi Wuwu decoction (HGWD) infusion packs
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Entecavir or Tenofovir in Patients With Chronic Hepatitis b Who Have Received Nucleoside (Acid) Therapy
Status: UNKNOWN
Conditions: Chronic Hepatitis b
Interventions: DRUG: TDF tablet|DRUG: Entecavir Tablet|DRUG: QL-007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Chocolate or Sevoflurane: Use of Parosmia to Facilitate More Cooperative Inhalation Inductions in Children
Status: NOT_YET_RECRUITING
Conditions: Anesthesia|Pediatrics
Interventions: OTHER: Inhalation induction with parosmia
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes
Status: COMPLETED
Conditions: Type 2 Diabetes
Interventions: DRUG: ITCA 650|OTHER: ITCA placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Status: ENROLLING_BY_INVITATION
Conditions: Obesity, Morbid|Metabolic Syndrome|NASH - Nonalcoholic Steatohepatitis
Interventions: PROCEDURE: 50 cm BP limb length|PROCEDURE: 100 cm BP limb length|PROCEDURE: 150 cm BP limb length
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Quality Control of CE-Certified Phonak Hearing Aids - 2017_13
Status: COMPLETED
Conditions: Hearing Loss, Bilateral Sensorineural, Progressive
Interventions: DEVICE: Line extension of the Phonak Audéo B product family|DEVICE: Phonak Audéo B
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A RCT of Oral S-1 in Combination With Sequential HAIC of Oxaliplatin After TACE in Patients With Advanced HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: S-1
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Validation and Feasibility in Clinical Practice and Concordance of an Automated System Coupling an RGB-D Camera and a Software Based on Artificial Intelligence for the Measurement of Shoulder Range of Motion for Patients Operated on a Total Reversed Shoulder Prosthesis.
Status: UNKNOWN
Conditions: Arthroplasty Complications
Interventions: PROCEDURE: shoulder arthroplasty
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Analysis of Transcriptomic Profile of Graft-versus-host Disease (GHVD) After Allogeneic Grafting of Hematopoietic Stem Cells
Status: UNKNOWN
Conditions: Graft Vs Host Disease|Hematopoietic Stem Cells
Interventions: OTHER: Transcriptomic analysis of GVHD biopsies
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of LUCAR-20SP in Subjects With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Status: RECRUITING
Conditions: Relapsed B-cell Non-Hodgkin Lymphoma|Refractory B-cell Non-Hodgkin Lymphoma
Interventions: BIOLOGICAL: LUCAR-20SP cells
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Sumatriptan and Placebo on CGRP Induced Headache
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: Calcitonin Gene Related Peptide|DRUG: Sumatriptan 50 mg|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase I Trial of SIM1811-03 in Subjects With Advanced Solid Tumors and Cutaneous T-cell Lymphoma
Status: RECRUITING
Conditions: Advanced Solid Tumor|Cutaneous T-cell Lymphoma (CTCL)
Interventions: DRUG: SIM1811-03
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Early Feeding After Bowel Anastomosis in Neonates or Infants
Status: COMPLETED
Conditions: Enteral Feeding|Neonate|Infant|Intestinal Anastomosis Complication
Interventions: DIETARY_SUPPLEMENT: early oral feeding or early enteral nurtrion
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: PEMF in the Treatment of Fresh Distal Radius Fractures
Status: UNKNOWN
Conditions: Distal Radius Fracture
Interventions: DEVICE: Fracture Healing Patch (FHP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TaurusOne® Transcatheter Aortic Valve Replacement System With Retrievable Delivery Catheter System
Status: COMPLETED
Conditions: Aortic Stenosis
Interventions: COMBINATION_PRODUCT: The experimental apparatus consisted of artificial aortic valve, transporter and grip-loading system.
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Collaborative Care With Smart Health Management Program for Patients With Chronic Illness
Status: COMPLETED
Conditions: Osteoporosis|Chronic Respiratory Disease|Arthritis|Osteopenia
Interventions: BEHAVIORAL: Tele-coaching programs|BEHAVIORAL: ICT programs|BEHAVIORAL: A book about chronic disease
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma
Status: COMPLETED
Conditions: Endometrial Cancer|Gastrointestinal Stromal Tumor|Ovarian Cancer|Sarcoma|Small Intestine Cancer
Interventions: DRUG: imatinib mesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Effectiveness of Kinesio Tape in Morning Stiffness and Functional Capacity in Patients With Rheumatoid Arthritis.
Status: COMPLETED
Conditions: Wrist Morning Stiffness
Interventions: PROCEDURE: Kenzo Kase Method|DEVICE: Kinesio Taping
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without AP 10-701 for Intestinal Schistosomiasis in Healthy Exposed Adults
Status: COMPLETED
Conditions: Schistosomiasis
Interventions: BIOLOGICAL: GLA-AF|BIOLOGICAL: Hepatitis B Virus Vaccine (Recombinant)|BIOLOGICAL: Sm-TSP-2/Alhydrogel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteer
Interventions: DRUG: Aspirin|DRUG: rivaroxaban low dose|DRUG: rivaroxaban high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: Study of Medication Patch to Treat Children Ages 6-12 With ADHD
Status: COMPLETED
Conditions: ADHD|Attention Deficit Hyperactivity Disorder
Interventions: DRUG: Methylphenidate Transdermal System|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gastroesophageal Reflux During LMA in Control Ventilation (LMA, Laryngeal Mask Airway)
Status: UNKNOWN
Conditions: Gastroesophageal Reflux
Interventions: PROCEDURE: control ventilation|PROCEDURE: spontaneous ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation
Status: COMPLETED
Conditions: Myocardial Ischemia
Interventions: PROCEDURE: Intensive medical therapy|PROCEDURE: Percutaneous Coronary Intervention (PCI) plus intensive medical therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose:
Clinical trial: Telehealth for Weight Maintenance of African-American Women ("Exercise Your Faith")
Status: COMPLETED
Conditions: Overweight|Obesity
Interventions: BEHAVIORAL: Weight Loss Church Program|BEHAVIORAL: Telephone Counseling|BEHAVIORAL: Telehealth Support
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Achieving Meaningful Clinical Benchmarks With Ekso Gait Training During Acute Stroke Inpatient Rehabilitation.
Status: RECRUITING
Conditions: Stroke|Stroke, Acute|Cerebrovascular Accident|Cerebrovascular Accident, Acute
Interventions: DEVICE: Ekso gait training|PROCEDURE: Standard physical therapy
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: PD-1 Inhibitor Plus Chemotherapy With or Without Radiotherapy in Patients With Metastatic Esophageal Cancer
Status: RECRUITING
Conditions: Esophageal Neoplasms
Interventions: RADIATION: Radiation|DRUG: TP or PF regimen depended on investigator's choice.|BIOLOGICAL: PD-1 inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pain Management With Virtual Reality Hypnosis
Status: RECRUITING
Conditions: Hypnosis|Labor Pain|Virtual Reality|Labor Induction|Latent Period
Interventions: DRUG: painkiller|OTHER: hypnosis group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Effects of LDX on Cognitive Processes and Appetite
Status: TERMINATED
Conditions: Binge Eating|Eating Behavior
Interventions: DRUG: Placebo oral tablet|DRUG: Lisdexamfetamine Dimesylate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy
Status: WITHDRAWN
Conditions: Tonsillectomy With or Without Adenoidectomy
Interventions: DRUG: Ibuprofen|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Text Message Vaccine Reminders for Adolescents With Chronic Medical Conditions
Status: COMPLETED
Conditions: Vaccination
Interventions: OTHER: educational text message reminders|OTHER: conventional text message reminders
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Minocycline for the Treatment of Early-Phase Schizophrenia
Status: COMPLETED
Conditions: Negative and Cognitive Symptoms in Schizophrenia
Interventions: DRUG: Minocycline|DRUG: Placebo (200 mg/day)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective Cohort Study of Neoadjuvant Chemotherapy Plus Sintillumab in the Treatment of Resectable NSCLC
Status: NOT_YET_RECRUITING
Conditions: Resectable Non-small Cell Lung Cancer
Interventions: DRUG: sintilimab plus platinum-based chemotherapy|DRUG: sintilimab plus platinum-based chemotherapy|DRUG: sintilimab plus platinum-based chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: An Expanded Access Protocol for Mobocertinib in Refractory Non-small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Exon20 Insertion Mutations
Status: APPROVED_FOR_MARKETING
Conditions: Carcinoma, Non-Small-Cell Lung
Interventions: DRUG: Mobocertinib 160 mg
Study Type: EXPANDED_ACCESS
Clinical trial: A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors
Status: RECRUITING
Conditions: Colorectal Cancer|Cholangiocarcinoma|Appendiceal Adenocarcinoma|Pancreatic Adenocarcinoma|Gastric Adenocarcinoma|Endometrial Adenocarcinoma|Triple Negative Breast Cancer|Ovarian Cancer|Prostate Cancer
Interventions: DRUG: APL-5125
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: rhIL-7-hyFc on Increasing Lymphocyte Counts in Patients With Newly Diagnosed Non-severe Lymphopenic Gliomas Following Radiation and Temzolomide
Status: RECRUITING
Conditions: Glioma
Interventions: DRUG: rhIL-7-hyFc|DRUG: Placebo|DRUG: Temozolomide|RADIATION: Radiation therapy|PROCEDURE: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: AI Quantitative Coronary Angiography Versus Optical Coherent Tomography Guidance for Coronary Stent Implantation
Status: ACTIVE_NOT_RECRUITING
Conditions: Coronary Vessels|Procedure PCI
Interventions: OTHER: Intervention Procedure: PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Test the Safety, Pharmacokinetics, and Efficacy of UCB9741 in Healthy Study Participants and in Study Participants With Atopic Dermatitis
Status: COMPLETED
Conditions: Atopic Dermatitis
Interventions: DRUG: UCB9741|DRUG: Intravenous Placebo|DRUG: Subcutaneous Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Remifentanil for General Anesthesia in Preeclamptics
Status: UNKNOWN
Conditions: Pre-Eclampsia|Hypertension, Pregnancy-Induced|Pregnancy Complications
Interventions: DRUG: Remifentanil|DRUG: Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: Silexan in the Treatment Of Posttraumatic Stress Disorder Trial
Status: RECRUITING
Conditions: Post Traumatic Stress Disorder
Interventions: DRUG: Silexan|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cognitive Therapy for Unipolar Depression: Efficacy of a Dilemma-Focused Intervention
Status: COMPLETED
Conditions: Major Depressive Disorder|Dysthymic Disorder
Interventions: BEHAVIORAL: Combined Cognitive Behavioral and Dilemma-Focused Therapy|BEHAVIORAL: Cognitive Behavioral Therapy for Depression
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: QUILT-3.009: Patients With Stage III (IIIB) or Stage (IV) Merkel Cell Carcinoma (MCC)
Status: TERMINATED
Conditions: Stage IIIB Merkel Cell Carcinoma|Stage IV Merkel Cell Carcinoma
Interventions: BIOLOGICAL: aNK (NK-92)|BIOLOGICAL: aNK (NK-92) + N-803
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Testing Cabozantinib, Crizotinib, Savolitinib and Sunitinib in Kidney Cancer Which Has Progressed
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Papillary Renal Cell Carcinoma|Metastatic Papillary Renal Cell Carcinoma|Stage III Renal Cell Cancer AJCC v7|Stage IV Renal Cell Cancer AJCC v7|Type 1 Papillary Renal Cell Carcinoma|Type 2 Papillary Renal Cell Carcinoma|Unresectable Renal Cell Carcinoma
Interventions: PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Scan|DRUG: Cabozantinib S-malate|PROCEDURE: Computed Tomography|DRUG: Crizotinib|DRUG: Savolitinib|DRUG: Sunitinib Malate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema
Status: RECRUITING
Conditions: Thoracic Empyema
Interventions: PROCEDURE: video assisted thoracoscopy (VATS)|PROCEDURE: open thoracotomy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of AK104+Lenvatinib in Combination With Transarterial Chemoembolization (TACE) Versus TACE in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: AK104|DRUG: Lenvatinib|PROCEDURE: TACE|OTHER: Placebo for AK104|OTHER: Placebo for Lenvatinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Superiority Trial Evaluating Digitalized Information Media for Patients With Advanced Sarcomas Receiving Second Line Treatment.
Status: RECRUITING
Conditions: Sarcoma Metastatic|Locally Advanced Soft Tissue Sarcoma
Interventions: OTHER: Dematerialized Personalized Care Plan (ePCP)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Impact of Docosahexaenoic Acid on the Prevention of Necrotizing Enterocolitis in Preterm Neonates
Status: UNKNOWN
Conditions: Necrotizing Enterocolitis
Interventions: DIETARY_SUPPLEMENT: Docosahexaenoic Acid|OTHER: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Effectiveness of Four Transition Dietary Regimens in the Hospital Management of Children With Kwashiorkor.
Status: COMPLETED
Conditions: Severe Acute Malnutrition|Kwashiorkor|Nutritional Edema
Interventions: DIETARY_SUPPLEMENT: Standard F100|DIETARY_SUPPLEMENT: Standard F75 + Plumpynut|DIETARY_SUPPLEMENT: Alternative F75 with CMV + Plumpynut|DIETARY_SUPPLEMENT: Alternative F75 without CMV + Plumpynut
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Pain Treatment on Depression in Patients With Dementia
Status: COMPLETED
Conditions: Depression|Pain|Dementia
Interventions: DRUG: Paracetamol|DRUG: Buprenorphine|DRUG: Paracetamol placebo|DRUG: Buprenorphine placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy Study of Extended-Release Niacin/Lovastatin Versus Usual Care
Status: COMPLETED
Conditions: Hyperlipidemia|Mixed Hyperlipidemia|Dyslipidemia
Interventions: DRUG: Niacin Extended Release/Lovastatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Aldosterone Blockade in Heart Failure
Status: COMPLETED
Conditions: Heart Failure
Interventions: DRUG: Spironolactone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quetiapine Treatment for Pediatric Delirium
Status: WITHDRAWN
Conditions: Delirium
Interventions: DRUG: Quetiapine|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quality of Life in Adults Impaired Functioning - A Randomized Controlled Trial of Bidet vs Usual Toileting
Status: TERMINATED
Conditions: Toileting in Adults With Impaired Functional Status|Caregiver Burden for Those Who Care for Adults With Impaired Functional Status|UTI in Adults With Impaired Functional Status
Interventions: BEHAVIORAL: Bidet use|OTHER: Regular toileting
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Vitamin D Replacement Using Oral Thin Film (OTF) Cholecalciferol in Patients Undergoing Hematopoietic Stem Cell Transplantation
Status: COMPLETED
Conditions: Vitamin D Deficiency|Hematopoietic Stem Cell Transplantation (HSCT)
Interventions: DIETARY_SUPPLEMENT: Oral Thin Film (OTF) Cholecalciferol (Vitamin D3)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of TAK-559 in Combination With Metformin in Patients With Type 2 Diabetes Mellitus.
Status: TERMINATED
Conditions: Diabetes Mellitus
Interventions: DRUG: TAK-559 and metformin|DRUG: TAK-559 and metformin|DRUG: Metformin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Effectiveness of Electronically Controlled Prosthetic Ankle
Status: RECRUITING
Conditions: Amputation
Interventions: DEVICE: Conventional ankle prosthesis|DEVICE: Meridium® (Microprocessor ankle prosthesis)|DEVICE: RoFT® (Microprocessor ankle prosthesis)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Lesinurad Interaction Study With Ranitidine
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: lesinurad 400 mg|DRUG: ranitidine 150 mg|DRUG: lesinurad 400 mg + ranitidine 150 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dexamethasone for Post-cesarean Delivery Pain
Status: COMPLETED
Conditions: Pain, Postoperative|Postoperative Nausea and Vomiting
Interventions: DRUG: Dexamethasone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Immuno-Augmentation With GM-CSF of Pneumococcal Vaccine in Chronic Lymphocytic Leukemia Patients
Status: COMPLETED
Conditions: Leukemia
Interventions: DRUG: Sargramostim (GM-CSF)|BIOLOGICAL: Pneumococcal Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apatinib as the Maintenance Therapy for Extensive Stage Small Cell Lung Cancer After Combined With Etoposide/Cisplatin
Status: UNKNOWN
Conditions: Small Cell Lung Cancer
Interventions: DRUG: apatinib;etoposide and cisplatin|DRUG: placebo;etoposide and cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers
Status: RECRUITING
Conditions: Gastric Cancer|GastroEsophageal Cancer|Gastroesophageal Junction Adenocarcinoma
Interventions: OTHER: MDASI-GI
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With Asthma
Status: RECRUITING
Conditions: Asthma
Interventions: COMBINATION_PRODUCT: Budesonide/Albuterol metered dose inhaler, MDI|COMBINATION_PRODUCT: Albuterol sulfate metered dose inhaler, MDI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose-regimen Finding Study to Evaluate Safety, Tolerability, Pharmacokinetics and Activity of Oratecan in Subjects With Advanced Malignancies
Status: COMPLETED
Conditions: Solid Tumor
Interventions: DRUG: Oratecan
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Glycemic Control Among Diabetics Using Three Different Pen Needles
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1|Diabetes Mellitus, Type 2
Interventions: DEVICE: 4mm x 32G pen needle|DEVICE: 8mm x 31G pen needle|DEVICE: 5mm x 31G pen needle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Optimizing Provider Training in Eating Disorders (OPTED)
Status: ACTIVE_NOT_RECRUITING
Conditions: Anorexia Nervosa|Atypical Anorexia Nervosa
Interventions: BEHAVIORAL: Web-based training|BEHAVIORAL: Live training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: 5FU/VL Vs LV5FU2 + CPT11 in Stage II-III Resected Rectal Cancer
Status: UNKNOWN
Conditions: Cancer of the Rectum
Interventions: PROCEDURE: 5FU/LV Mayo Clinic or LV5FU2|PROCEDURE: LV5FU2 + irinotecan
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention
Status: COMPLETED
Conditions: Peripheral Arterial Disease
Interventions: DIETARY_SUPPLEMENT: Pro-Omega|OTHER: Pro-Omega Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bioequivalence Study of Metoprolol Succinate Extended Release Tablets 50 mg
Status: COMPLETED
Conditions: Fasting
Interventions: DRUG: Metoprolol Succinate ER Tablets 50 mg|DRUG: 'TOPROL-XL®' ER Tablets 50 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: PET and MRI Brain Imaging of Bipolar Disorder
Status: COMPLETED
Conditions: Bipolar Disorder|Bipolar Depression|Unipolar Depression
Interventions: DRUG: Lithium|DRUG: Lamotrigine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Ischemic Preconditioning Claudication Study
Status: COMPLETED
Conditions: Intermittent Claudication|Ischemia Vascular|Peripheral Arterial Disease|Peripheral Vascular Disease
Interventions: OTHER: Ischemic Preconditioning|OTHER: Control Group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Lateral Suspension With Mesh & Sacrocervicopexy for the Treatment of Uterine Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse|Pelvic Floor Prolapse
Interventions: PROCEDURE: Uterus-preserving laparoscopic lateral suspension with mesh|PROCEDURE: Uterus-preserving laparoscopic sacrocervicopexy with mesh
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic and/or Biologic DMARDS
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: DRUG: tocilizumab [RoActemra/Actemra]
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Controlled Study to Evaluate the Safety and Efficacy of the Predictix Antidepressant Clinician Support Tool
Status: UNKNOWN
Conditions: Major Depressive Disorder
Interventions: DEVICE: Predictix Antidepressant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Trial Investigating the NN1250 Concentration-time Curve in Subjects With Various Degrees of Renal Impairment and in Subjects With Normal Renal Function
Status: COMPLETED
Conditions: Diabetes|Healthy
Interventions: DRUG: insulin degludec|DRUG: insulin degludec|DRUG: insulin degludec|DRUG: insulin degludec|DRUG: insulin degludec
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: SGLT2 Inhibition in Combination With Diuretics in Heart Failure
Status: COMPLETED
Conditions: Heart Failure|Type 2 Diabetes Mellitus
Interventions: DRUG: Empagliflozin 25mg|DRUG: Placebo oral capsule|DRUG: Frusemide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Ultrasound-guided Central Venous Catherterization Via the Lower Internal Jugular Vein or the Subclavian Vein
Status: COMPLETED
Conditions: Central Venous Access
Interventions: PROCEDURE: Central venous catheterization
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Medication Reconciliation Using Electronic Pharmaceutical Record: A Multicenter Study in the Hospitalized Elderly
Status: COMPLETED
Conditions: Adverse Drug Event
Interventions: OTHER: Medication reconciliation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of Hyaluronate Injectable Viscosupplement for Treatment of Osteoarthritis of the Knee
Status: COMPLETED
Conditions: Osteoarthritis
Interventions: DEVICE: Hyaluronate Injectable Viscosupplement|DEVICE: Euflexxa IA injection|DEVICE: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Comparison of Engerix B Vaccine Versus Sci-B-Vac Vaccine in Celiac Patients
Status: UNKNOWN
Conditions: Celiac Disease
Interventions: BIOLOGICAL: Hepatitis B vaccination (Sci-B-Vac)|BIOLOGICAL: Hepatitis B vaccination (EngerixB)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Norms Expansion and Validation for IntelliSpace Cognition
Status: COMPLETED
Conditions: Cognitive Functioning of Healthy Individuals
Interventions: DEVICE: Philips IntelliSpace Cognition (ISC).|DIAGNOSTIC_TEST: Paper-Pencil Tests.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Study of SP-3164 in Relapsed or Refractory Non-Hodgkin's Lymphoma
Status: NOT_YET_RECRUITING
Conditions: Lymphoma, Non-Hodgkin's, Adult
Interventions: DRUG: SP-3164
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines
Status: COMPLETED
Conditions: Hepatitis A
Interventions: BIOLOGICAL: Attenuated HAV Vaccine, H2 Strain|BIOLOGICAL: Attenuated HAV Vaccine, L-A-1 Strain|BIOLOGICAL: Inactivated HAV Vaccine, Lu8 Strain|BIOLOGICAL: Inactivated HAV Vaccine, TZ84 Strain
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Comparison of Vibration and Dry Needle in Trigger Point Therapy
Status: COMPLETED
Conditions: Myofascial Pain Syndrome|Trigger Point Pain, Myofascial
Interventions: OTHER: Dry needle|DEVICE: Localize vibration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
Status: TERMINATED
Conditions: Spinal Cord Injuries
Interventions: OTHER: AIH - Intermittent Hypoxia - hypoxia air mixture|OTHER: SHAM - Intermittent Room Air - room air mixture|DEVICE: TESS - Transcutaneous Electrical Spinal Cord Stimulation + Functional Task Practice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer
Status: RECRUITING
Conditions: Breast Cancer
Interventions: DRUG: Abemaciclib|DRUG: Hydroxychloroquine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Low-Fluence PRP for PDR
Status: TERMINATED
Conditions: Proliferative Diabetic Retinopathy
Interventions: DEVICE: Low-fluence PRP with 532nm green LASER|DEVICE: Full-Fluence PRP with 532nm LASER
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: High-frequency rTMS on the Cerebellar to Improve Post-stroke Cognitive Impairment
Status: NOT_YET_RECRUITING
Conditions: Post-stroke Cognitive Impairment|Ischemic Stroke
Interventions: DEVICE: rTMS group|DEVICE: control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Randomized Controlled Trial to Determine the Efficacy of an auGmented reAlity gaMe in pediatrIc caNcer Patients Who Are Opioid Tolerant Users Undergoing Surgery to Reduce Post-operative Opioid Use
Status: WITHDRAWN
Conditions: Cancer
Interventions: DEVICE: IPAD|DEVICE: Augmented Reality
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: CART19 Cells Effects in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma
Status: RECRUITING
Conditions: Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia|Non-Hodgkin's Lymphoma Refractory|Non-Hodgkin's Lymphoma, Relapsed
Interventions: DRUG: Autologous CAR19 T lymphocytes
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Eribulin Mesylate in Treating Patients With Locally Advanced or Metastatic Cancer of the Urothelium and Kidney Dysfunction
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Urothelial Carcinoma|Locally Advanced Urothelial Carcinoma|Metastatic Urothelial Carcinoma|Recurrent Urothelial Carcinoma|Stage III Bladder Urothelial Carcinoma AJCC v6 and v7|Stage IV Bladder Urothelial Carcinoma AJCC v7|Unresectable Urothelial Carcinoma
Interventions: DRUG: Eribulin Mesylate|OTHER: Laboratory Biomarker Analysis|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Activated Recombinant Human Factor VII in Pelvic-acetabular Fracture Reconstruction
Status: COMPLETED
Conditions: Acquired Bleeding Disorder|Trauma
Interventions: DRUG: activated recombinant human factor VII|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate Addiction
Status: COMPLETED
Conditions: Opiate Addiction
Interventions: DRUG: Methadone|DRUG: Diamorphine hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot to Evaluate VR-Therapy on People With Epilepsy and Related Anxiety
Status: COMPLETED
Conditions: Epilepsy|Anxiety Disorders and Symptoms
Interventions: DEVICE: Participants Receiving VR-Exposure Therapy Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Anisodamine Hydrobromide Combined With Low-molecular-weight Heparin in the Treatment of Patients With Sepsis
Status: ENROLLING_BY_INVITATION
Conditions: Sepsis
Interventions: DRUG: Anisodamine hydrobromide combined with heparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Study of Pemetrexed Versus Pemetrexed Plus Erlotinib as Treatment of Nonsquamous Non-Small Cell Lung Cancer (NSCLC)
Status: COMPLETED
Conditions: Histological or Cytological Diagnosis of Locally Advanced or Metastatic NSCLC of Nonsquamous Histology and Not Amenable to Curative Therapy.
Interventions: DRUG: Pemetrexed|DRUG: Erlotinib|DRUG: Pemetrexed|DRUG: Erlotinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION