pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy
Status: RECRUITING
Conditions: Progressive Multifocal Leukoencephalopathy
Interventions: DRUG: NT-I7
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Implementation of Vascular Care Team to Improve Medical Management of PAD Patients
Status: COMPLETED
Conditions: Peripheral Artery Disease
Interventions: OTHER: Intervention A - Vascular Care + site 6MWT administration|OTHER: Intervention B - Standard Care + site 6MWT administration|OTHER: Intervention A - Vascular Care + CPC EQuIP 6MWT administration|OTHER: Intervention B - Standard Care + CPC EQuIP 6MWT administration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Cognitive Control & the Functional Organization of the Frontal Cortex
Status: RECRUITING
Conditions: Multitasking Behavior and Neural Representations Associated With Multitasking Ability|Healthy Volunteers|Executive Function
Interventions: BEHAVIORAL: Multitask Practice Intervention (MPI)|BEHAVIORAL: Single-task Practice Intervention (SPI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Effect of Exercise on Myokine Production in Aging Persons
Status: RECRUITING
Conditions: Aging|Exercise
Interventions: OTHER: Exercise training|BEHAVIORAL: Questionnaire|PROCEDURE: Percutaneous muscle biopsy|PROCEDURE: Blood sample
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Patients With Major Depressive Disorder With MK0869 (0869-059)
Status: COMPLETED
Conditions: Major Depressive Disorder
Interventions: DRUG: MK0869, aprepitant|DRUG: Comparator: paroxetine HCL
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Multi - Center Study Of PET Imaging With [F-18] FLT & [F-18] FDG in Cancer Patients for Treatment Evaluation
Status: COMPLETED
Conditions: Lung Cancer|Head and Neck Cancer
Interventions: DRUG: [F-18]FLT
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Improving Maternal heAlth by Reducing Malaria in African HIV Women
Status: COMPLETED
Conditions: Malaria|HIV/AIDS|Pregnancy Related
Interventions: DRUG: Dihydroartemisinin-piperaquine (DHA-PPQ)|DRUG: Placebo Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy/ Safety of Omalizumab in Patients With Seasonal Allergic Asthma and Seasonal Allergic Rhinoconjunctivitis
Status: COMPLETED
Conditions: Allergic Asthma
Interventions: DRUG: Depigoid|DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Tenalisib in Patients With Metastatic Triple Negative Breast Cancer (TNBC)
Status: RECRUITING
Conditions: Triple Negative Breast Cancer (TNBC)
Interventions: DRUG: Tenalisib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Potassium and Sodium to Control Blood Pressure in Hypertensives
Status: COMPLETED
Conditions: Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases
Interventions: BEHAVIORAL: diet, sodium-restricted|BEHAVIORAL: diet, potassium-supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: |Primary Purpose: TREATMENT
Clinical trial: A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors
Status: RECRUITING
Conditions: Cervical Cancer|Gastric/Gastroesophageal Junction Adenocarcinoma|Microsatellite Stable Colorectal Cancer|Non-Small-Cell Lung Cancer|Squamous Cell Carcinoma of Head and Neck|Carcinoma, Renal Cell|Urothelial Carcinoma|Pancreatic Adenocarcinoma|Melanoma|Ovarian Neoplasms|Triple Negative Breast Neoplasms
Interventions: DRUG: BMS-986340|DRUG: BMS-936558-01|DRUG: Docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Translational Study of the Effects of Neural Mobilization in Patients With Lomboisquiatalgia
Status: COMPLETED
Conditions: Low Back Pain, Mechanical|Pain|Neuropathic Pain
Interventions: OTHER: Neural Mobilization (exercise)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages.
Status: COMPLETED
Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: DRUG: Nasal Mometasone Rinse
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Treatment for Ulnar Neuropathy at the Elbow
Status: UNKNOWN
Conditions: Peripheral Nervous System Diseases|Nerve Compression Syndromes|Cubital Tunnel Syndrome
Interventions: PROCEDURE: Simple decompression of the ulnar nerve|BEHAVIORAL: Conservative treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Anti-PD-1/PD-L1 Treatment +/- UV1 Vaccination in Patients With Non-small Cell Lung Cancer
Status: RECRUITING
Conditions: Oncology|NSCLC Stage IV|NSCLC, Stage III
Interventions: BIOLOGICAL: UV1|DRUG: Sagramostim|DRUG: Anti-PD-1/PD-L1 treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Thermal Ablation Combined With Anlotinib and TQB2450 Solution for HCC
Status: UNKNOWN
Conditions: Hepatocellular Carcinoma|Thermal Ablation|Anlotinib|PDL-1
Interventions: DRUG: Anlotinib and TQB2450 solution|DRUG: TQB2450 solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Endostar Plus EGFR-TKI（Epidermal Growth Factor Receptor-Tyrosine-Kinase Inhibitor） as a Treatment of EGFR Mutation-positive NSCLC
Status: UNKNOWN
Conditions: Advanced Cancer|Lung Cancer, Nonsmall Cell
Interventions: DRUG: EGFR-TK Inhibitor
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Safety, Tolerability, and Pharmacokinetics of CC-92480 Formulations in Healthy Adult Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CC-92480|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase II Study Comparing The Efficacy Of Venetoclax + Fulvestrant Vs. Fulvestrant In Women With Estrogen Receptor-Positive, Her2-Negative Locally Advanced Or Metastatic Breast Cancer Who Experienced Disease Recurrence Or Progression During Or After CDK4/6 Inhibitor Therapy
Status: TERMINATED
Conditions: Estrogen Receptor-positive (ER+)/Human Epidermal Growth Factor Receptor (HER2)-Negative Locally Advanced or Metastatic Breast Cancer
Interventions: DRUG: Venetoclax|DRUG: Fulvestrant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Fixed and Removable Space Maintainer on Some Salivary Parameters: An In-Vivo Study
Status: NOT_YET_RECRUITING
Conditions: Premature Loss of Primary Teeth
Interventions: DEVICE: lower lingual holding arch space maintainer|DEVICE: Removable partial denture space maintainer
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Physical Activity in Children With Wolff-Parkinson-White Syndrome
Status: RECRUITING
Conditions: Wolff-Parkinson-White Syndrome
Interventions: OTHER: Cardiopulmonary exercise test|OTHER: Atrial-Ventricular Strain Analysis|OTHER: Arterial Stiffness Measurement|OTHER: Physical Activity Level|OTHER: Physical Activity Barriers Assesment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Allogeneic Hematopoietic Stem Cell Transplantation With Bevacizumab for Advanced Solid Tumor
Status: TERMINATED
Conditions: Breast Cancer|Ovarian Cancer
Interventions: DRUG: Bevacizumab|PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Fludarabine|DRUG: Melphalan|DRUG: Thymoglobulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Early Patient Access Single Named Patient Program for the Use of Ulocuplumab for the Treatment of Multiple Myeloma
Status: NO_LONGER_AVAILABLE
Conditions: Multiple Myeloma in Relapse|Multiple Myeloma
Interventions: DRUG: Ulocuplumab|DRUG: Lenalidomide|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: EXPANDED_ACCESS
Clinical trial: Interest of Urinary Oxygen Partial Pressure (PO2u) in Predicting the Onset or Recovery of Acute Renal Failure During Shock States - OXYpi Study
Status: RECRUITING
Conditions: Shock Circulatory
Interventions: BIOLOGICAL: Continuous measurement of uPO2 (both groups)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SCREENING
Clinical trial: CCT for Comprehensive Risk Stratification Following STEMI
Status: RECRUITING
Conditions: Myocardial Infarction
Interventions: DIAGNOSTIC_TEST: Cardiac Computed Tomography|DIAGNOSTIC_TEST: Cardiac Magnetic Resonance
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: A Pharmacokinetics, Pharmacodynamics, and Safety Study of an Oral Contraceptive Containing Norethindrone and Ethinyl Estradiol When Co-administered With GSK1322322 in Healthy Adult Women
Status: WITHDRAWN
Conditions: Infections, Bacterial
Interventions: DRUG: GSK1322322|DRUG: EE/NE|DRUG: GSK1322322 Placebo|DRUG: EE/NE Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Phase II Clinical Trial to Evaluate the Efficacy and Safety of LPM3480392 Injection for Moderate to Severe Pain After Orthopedic Surgery
Status: RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Placebo|DRUG: morphine hydrochloride injection|DRUG: LPM3480392 Injection|DRUG: LPM3480392 Injection|DRUG: LPM3480392 Injection|DRUG: LPM3480392 Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
Status: RECRUITING
Conditions: Knee Osteoarthritis
Interventions: DRUG: Duloxetine|DRUG: Celecoxib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Discomfort in Upper Airways Due to intubation-a Randomized Controlled Trial
Status: RECRUITING
Conditions: Postoperative Complications|Intubation; Difficult or Failed|Intubation Complication
Interventions: DRUG: Lidocaine topical
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Study of PTX-200 (Triciribine) Plus Cytarabine in Refractory or Relapsed Acute Leukemia
Status: COMPLETED
Conditions: Acute Leukemia
Interventions: DRUG: PTX-200|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pharmacokinetic, Safety and Immunogenicity Study of CMAB809 and Herceptin in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: CMAB809|DRUG: Trastuzumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Cisplatin With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer
Status: COMPLETED
Conditions: Head and Neck Cancer
Interventions: BIOLOGICAL: cetuximab|DRUG: cisplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Cryospray Therapy for Benign Airway Stenosis
Status: RECRUITING
Conditions: Stenosis Trachea
Interventions: DEVICE: The truFreeze Spray Cryotherapy|DEVICE: Ballon dilation|DEVICE: Radial Incision
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Recruitment Maneuvers in Early Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Patients
Status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome|Lung Injury, Acute
Interventions: PROCEDURE: Lung recruitment maneuver|PROCEDURE: Lung protective strategy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Ultrasound-guided PENG Block in Total Hip Replacement
Status: COMPLETED
Conditions: Pain, Postoperative|Opioid Overdose
Interventions: PROCEDURE: Sham PENG block|PROCEDURE: Real PENG block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Study to Compare CAPTEM vs FOLFIRI as Second Line Treatment in Advanced, Colorectal Cancer Patients
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer
Interventions: DRUG: Capecitabine|DRUG: Temozolomide|DRUG: Irinotecan|DRUG: Fluorouracil|DRUG: Leucovorin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Local Anaesthetic in Colonic Surgery
Status: COMPLETED
Conditions: Colon Surgery
Interventions: DRUG: Ropivacaine|DRUG: 0.9% Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Vaccine Therapy in Treating Patients Receiving Trastuzumab For HER2-Positive Stage IIIB-IV Breast Cancer
Status: COMPLETED
Conditions: HER2-positive Breast Cancer|Male Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer
Interventions: BIOLOGICAL: HER-2/neu intracellular domain protein|PROCEDURE: leukapheresis|OTHER: laboratory biomarker analysis|BIOLOGICAL: sargramostim|OTHER: immunologic technique|BIOLOGICAL: synthetic tumor-associated peptide vaccine therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Poor-Prognosis Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: filgrastim|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: etoposide|DRUG: mesna|PROCEDURE: autologous bone marrow transplantation|PROCEDURE: peripheral blood stem cell transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Therapeutic Touch and Emotional Freedom Technique (EFT) on Postpartum Mood and Fatigue in Postpartum Women
Status: RECRUITING
Conditions: Fatigue|Emotion Regulation
Interventions: OTHER: Emotional freedom technique (EFT)|OTHER: Therapeutic touch (TD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Incidence, Clinical Characteristics and Outcome of Infective Endocarditis Among Intravenous Drug Abusers Versus Non-Drug Abusers.
Status: RECRUITING
Conditions: Infective Endocarditis
Interventions: DIAGNOSTIC_TEST: Echocardiography, Urine analysis , blood culture
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Participants With Myelofibrosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Myelofibrosis (MF)
Interventions: DRUG: Ruxolitinib|DRUG: Navitoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pd1 Antibody Sintilimab ± Chemoradiotherapy for Locally Advanced Rectal Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Colorectal Cancer Stage II|Colorectal Cancer Stage III
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine|DRUG: Sintilimab|RADIATION: radiotherapy|PROCEDURE: total mesorectal excision|OTHER: Watch and wait
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: First-in-Human Study With Single and Multiple Doses of TS-161 in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: TS-161|DRUG: TS-161 Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Evaluate the Safety of Tralokinumab in Adults and Adolescents With Uncontrolled Asthma
Status: TERMINATED
Conditions: Inadequately Controlled Asthma
Interventions: BIOLOGICAL: Tralokinumab open-label
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of RAD001/Everolimus in Autism and NeuroPsychological Deficits in Children With Tuberous Sclerosis Complex
Status: UNKNOWN
Conditions: Tuberous Sclerosis Complex|TSC Related Cognitive Disability|TSC Related Autism|TSC Related Learning Problems
Interventions: DRUG: Everolimus|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3561774 in Participants With Dyslipidemia
Status: COMPLETED
Conditions: Dyslipidemias
Interventions: DRUG: LY3561774|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Safety and Protectiveness of the Seasonal Influenza Vaccine for 2010-2011
Status: COMPLETED
Conditions: Influenza
Interventions: BIOLOGICAL: Fluviral 2010/11 Tri-valent Seasonal Influenza vaccine|BIOLOGICAL: Fluviral 2010/11 Tri-valent Seasonal Influenza vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Prospective, Randomized Trial of the Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post-Operative Opioid Use Disorder Symptoms
Status: UNKNOWN
Conditions: Opioid-use Disorder|Opioid Use Disorder, Mild
Interventions: DRUG: Buprenorphine|DRUG: Buprenorphine/naloxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Treatment of Children With ADHD Who do Not Fully Respond to Stimulants
Status: TERMINATED
Conditions: Attention Deficit Hyperactivity Disorder
Interventions: DRUG: aripiprazole|DRUG: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Trastuzumab and Vinorelbine in Advanced Breast Cancer
Status: TERMINATED
Conditions: Breast Cancer|Metastatic Breast Cancer
Interventions: DRUG: trastuzumab|DRUG: vinorelbine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Atrial Fibrillation and Other Cardiac Arrhythmias and Diseases After Radiotherapy for Breast Cancer : Watch Your HeaRT
Status: RECRUITING
Conditions: Breast Cancer|Radiation Toxicity|Atrial Fibrillation|Cardiac Arrhythmia|Cardiac Disease
Interventions: DIAGNOSTIC_TEST: Screening for atrial fibrillation and other cardiac arrhythmias and diseases
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
Status: RECRUITING
Conditions: Low Grade Astrocytoma|Low Grade Glioma|Metastatic Low Grade Astrocytoma|Metastatic Low Grade Glioma
Interventions: PROCEDURE: Biospecimen Collection|DRUG: Carboplatin|PROCEDURE: Magnetic Resonance Imaging|OTHER: Quality-of-Life Assessment|OTHER: Questionnaire Administration|DRUG: Selumetinib Sulfate|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ATG 037 Monotherapy and Combination Therapy With Pembrolizumab in Patients With Advanced Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: ATG-037|DRUG: KEYTRUDA ®( Pembrolizumab)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Velcade, Trisenox, Vitamin C and Melphalan for Myeloma Patients
Status: COMPLETED
Conditions: Myeloma
Interventions: DRUG: Trisenox (Arsenic Trioxide)|DRUG: Velcade (Bortezomib)|DRUG: Melphalan|DRUG: Vitamin C (Ascorbic Acid)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Immunogenicity Study of Recombinant Protein RBD Candidate Vaccine Against SARS-CoV-2 in Adult Healthy Volunteers (COVID-19)
Status: COMPLETED
Conditions: Covid19|SARS CoV 2 Infection
Interventions: BIOLOGICAL: COVID-19 vaccine HIPRA 10|BIOLOGICAL: COVID-19 vaccine HIPRA 20|BIOLOGICAL: COVID-19 vaccine HIPRA 40|BIOLOGICAL: Commercial COVID-19 vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: IRELAnD: Investigating the Role of Early Low-dose Aspirin in Diabetes
Status: UNKNOWN
Conditions: Pre-Gestational Diabetes
Interventions: DRUG: Aspirin|DRUG: Placebos
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study of MRG004A in Patients With Tissue Factor Positive Advanced or Metastatic Solid Tumors
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: MRG004A
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs. TNF Antibody Therapy
Status: COMPLETED
Conditions: Rheumatoid Arthritis
Interventions: BEHAVIORAL: Exercise|BEHAVIORAL: No exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Factor Xa Inhibitor, PRT054021, Against Enoxaparin for the Prevention of Venous Thromboembolic Events (EXPERT)
Status: COMPLETED
Conditions: Thromboembolism
Interventions: DRUG: Betrixaban|DRUG: Enoxaparin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Study of Finerenone to Investigate a Paediatric Formulation in Healthy Male Volunteers
Status: COMPLETED
Conditions: Pharmacokinetics
Interventions: DRUG: Finerenone (BAY94-8862): 1 0mg tablet|DRUG: Finerenone (BAY94-8862): 5 X 0.25 mg oro-dispersible tablets|DRUG: Finerenone (BAY94-8862): 1.25 mg oro-dispersible tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Plasma and Intracellular Concentrations of Raltegravir and Etravirine Administered Once Daily
Status: COMPLETED
Conditions: HIV-1 Infection|HIV Infections
Interventions: DRUG: Raltegravir|DRUG: Etravirine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Impact of Antiviral Therapy on Gastroesophageal Varices.
Status: COMPLETED
Conditions: Chronic Hepatitis C|Cirrhosis
Interventions: DRUG: Pegylated interferon alfa-2a + Ribavirin|DRUG: Pegylated interferon alfa-2a + Ribavirin + Boceprevir|DRUG: Pegylated interferon alfa-2a + Ribavirin +Telaprevir|DRUG: Ledipasvir/Sofosbuvir|DRUG: Ombitasvir/paritaprevir/ritonavir+Dasabuvir|DRUG: Daclatasvir+Sofosbuvir|DRUG: Simeprevir+Sofosbuvir
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Activated Protein C and Corticosteroids for Human Septic Shock
Status: COMPLETED
Conditions: Septic Shock
Interventions: DRUG: placebos|DRUG: hydrocortisone and fludrocortisone and placebo|DRUG: recombinant human activated protein C and placebos|DRUG: recombinant human activated protein C and hydrocortisone and fludrocortisone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Behavioral Weight Loss Program for Cancer Survivors in Maryland
Status: COMPLETED
Conditions: Breast Cancer|Prostate Cancer|Melanoma (Skin)|Endometrial Cancer|Gallbladder Cancer|Rectal Cancer|Kidney Cancer|Bladder Cancer
Interventions: BEHAVIORAL: Written Weight Loss Material|BEHAVIORAL: Weight Loss App|BEHAVIORAL: Behavioral Lifestyle Weight Loss Intervention (Coaching)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis
Status: ACTIVE_NOT_RECRUITING
Conditions: Inherited Retinal Dystrophy Due to RPE65 Mutations|Leber Congenital Amaurosis
Interventions: BIOLOGICAL: AAV2-hRPE65v2,voretigene neparvovec-rzyl
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated With Idiopathic Parkinson's Disease (PD) or Dementia With Lewy Bodies (DLB)
Status: COMPLETED
Conditions: Lewy Body Dementia
Interventions: DRUG: LY3154207|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Single-center Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of LCAR-L10D Cell Formulations Targeting CD19 and CD22 in Patients With CD19- and/or CD22-Positive Relapsed/Refractory B-cell Lymphoma
Status: TERMINATED
Conditions: Lymphoma, B-Cell
Interventions: DRUG: Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Therapeutic Drug Monitoring Study of Reduced-Dose Efavirenz (400 mg) in Combo Tablet for Patients Receiving Atripla With Viral Suppression in Taiwan
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: 3-in-1 tablet (EFV 400mg, TDF 300mg, 3TC 300mg)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Activities for Cognitive Enhancement of Seniors
Status: COMPLETED
Conditions: Aging
Interventions: BEHAVIORAL: Tai Chi|BEHAVIORAL: Guided autobiography|BEHAVIORAL: Qigong|BEHAVIORAL: Successful aging|BEHAVIORAL: Combination|BEHAVIORAL: Comparison
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Goals of Care Conversations Study
Status: ENROLLING_BY_INVITATION
Conditions: Seriously Ill Patients|Cancer|Heart Failure|Interstitial Lung Disease|Chronic Obstructive Pulmonary Disease|End-stage Renal Disease|End-stage Liver Disease|Dementia
Interventions: BEHAVIORAL: Clinician Implementation Strategy Stage 1: low intensity clinician training|BEHAVIORAL: Clinician Implementation Strategy Stage 2: high intensity clinician training|BEHAVIORAL: Low patient engagement|BEHAVIORAL: High patient engagement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Topical IL-1-Ra for Treatment of Posterior Blepharitis
Status: COMPLETED
Conditions: Posterior Blepharitis
Interventions: DRUG: 2.5% IL-1Ra|DRUG: Placebo|DRUG: 5% IL-1Ra
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Trial of Magrolimab (Hu5F9-G4) in Combination With Rituximab or Rituximab + Chemotherapy in Participants With Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma
Status: TERMINATED
Conditions: Non Hodgkin Lymphoma
Interventions: DRUG: Magrolimab|DRUG: Rituximab|DRUG: Gemcitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Soft Robotic Sock Intervention for Robot-assisted Ankle-foot Mobility in Post-stroke Patients
Status: UNKNOWN
Conditions: Stroke|DVT|Ankle Contracture
Interventions: DEVICE: Venous Assistance and Contracture Management System (VACOM)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Cyclophosphamide and Veliparib in Treating Patients With Locally Advanced or Metastatic Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Conditions: Locally Advanced Unresectable Breast Carcinoma|Metastatic Breast Carcinoma|Recurrent Breast Carcinoma|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|DRUG: Veliparib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Traumatic Brain Injury and Alzheimer's Disease/Related Dementias Caregiver Support Intervention
Status: RECRUITING
Conditions: Caregiver Burden|Caregiver Stress Syndrome|Caregiver Burnout
Interventions: OTHER: TBI-AD/ADRD Caregiver Support Intervention (TACSI)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Peripheral Stimulation of Acupuncture Points for Low Back Pain
Status: RECRUITING
Conditions: Low Back Pain
Interventions: PROCEDURE: Peripheral stimulation of acupuncture points (PSAP)|PROCEDURE: Peripheral nerve field stimulation (PNFS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of the Relapse Rate One Month After Discharge From Emergency Department for Asthmatic Patients Given a Strict Formalized Follow up Protocol
Status: COMPLETED
Conditions: Asthma
Interventions: BEHAVIORAL: 2: Intervention|BEHAVIORAL: 1: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Perimodiolar Implant Performance in Adults With Low-Frequency Residual Hearing
Status: ACTIVE_NOT_RECRUITING
Conditions: Sensorineural Hearing Loss|Low-Frequency Residual Hearing
Interventions: DEVICE: CI632 Slim Modiolar Electrode
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: A Study to Evaluate the Safety and Efficacy of PAC-14028 Cream in Rosacea
Status: COMPLETED
Conditions: Rosacea
Interventions: DRUG: PAC-14028 cream 0.1%|DRUG: PAC-14028 cream 0.3%|DRUG: PAC-14028 cream 1.0%|DRUG: PAC-14028 cream vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominal Aortic Aneurysm Screening Before Coronary Artery Bypass Surgery
Status: RECRUITING
Conditions: Coronary Artery Disease|Abdominal Aortic Aneurysm
Interventions: DIAGNOSTIC_TEST: Abdominal aortic Duplex ultrasound
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study to Evaluate YH003 in Combination With Toripalimab (Anti-PD-1 mAb) in Subjects With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors
Interventions: DRUG: YH003|DRUG: Toripalimab|DRUG: Nab-paclitaxel|DRUG: Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study
Status: COMPLETED
Conditions: Ulcer|Venous Ulcer|Skin Ulcer|Leg Ulcer
Interventions: DEVICE: NMBM|OTHER: Compression garments
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Interprofessional Versus Monoprofessional Case-based Learning in Childhood Cancer
Status: TERMINATED
Conditions: Interprofessional Education|Continuing Professional Development|Education|Case-based Learning
Interventions: OTHER: Interprofessional case-based learning
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: How Successful is Supplemental Intraseptal Anaesthesia in Patients With Mandibular Teeth Extraction or Irreversible Pulpitis
Status: COMPLETED
Conditions: Overcoming the Failure of Anesthesia in the Mandibular Teeth
Interventions: DRUG: 2% lidocaine with 1:000,000 epinephrine|DRUG: 4% articaine with 1:000,000 epinephrine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Dose-response Relationship and the Evidence Based Multisensory Stimulation Intervention
Status: COMPLETED
Conditions: Psychotic Disorders|Anxiety|Complementary Therapies|Clinical Trial
Interventions: BEHAVIORAL: multisensory stimulation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sonodynamic Therapy in Patients With Recurrent GBM
Status: RECRUITING
Conditions: Recurrent Glioblastoma|Glioblastoma Multiforme|GBM
Interventions: COMBINATION_PRODUCT: 5-ALA and Low-Intensity Focused Ultrasound (SDT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients
Status: COMPLETED
Conditions: Unilateral Cleft Lip and Palate|Cleft Lip|Cleft Palate|Developmental Disabilities|Restricted Language Development
Interventions: PROCEDURE: two stage palate surgical repair|PROCEDURE: One stage Palate Surgical repair
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: A Study of XSTEM-VLU in Patients With Difficult-to-heal Venous Leg Ulcers
Status: RECRUITING
Conditions: Venous Leg Ulcer
Interventions: BIOLOGICAL: XSTEM-VLU|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Randomized Controlled Trial of a Behavioral Training App
Status: RECRUITING
Conditions: Behavior, Child|Disruptive Behavior|Executive Dysfunction|Attention-deficit|Anxiety|Depression|Stress
Interventions: BEHAVIORAL: Treatment App|BEHAVIORAL: Sham app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: The ctDNA for Evaluating Whether to Use Adjuvant Therapy After SBRT in Patients With Early Lung Cancer
Status: NOT_YET_RECRUITING
Conditions: Stereotactic Body Radiation Therapy
Interventions: DRUG: drug adjuvant therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pramipexole and Emotional Processing
Status: COMPLETED
Conditions: Emotions|Motivation|Reward|Dopamine
Interventions: DRUG: Pramipexole|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol
Status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19|SARS-CoV2 Infection
Interventions: BIOLOGICAL: Ad5-triCoV/Mac|BIOLOGICAL: ChAd-triCoV/Mac
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Onalespib and CDKI AT7519 in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
Status: ACTIVE_NOT_RECRUITING
Conditions: Advanced Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Unresectable Solid Neoplasm
Interventions: DRUG: CDK Inhibitor AT7519|OTHER: Laboratory Biomarker Analysis|DRUG: Onalespib|OTHER: Pharmacological Study
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vitamin D Repletion in Coronary Artery Disease
Status: COMPLETED
Conditions: Vitamin D Deficiency|Coronary Artery Disease|Endothelial Dysfunction|Inflammation
Interventions: DRUG: Ergocalciferol|OTHER: Sugar pill
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nutritional Supplementation in Adults With Chronic Respiratory Disease
Status: COMPLETED
Conditions: Malnutrition|Pulmonary Disease, Chronic Obstructive|Other Pulmonary Disease, Chronic Obstructive
Interventions: DIETARY_SUPPLEMENT: Complete enteral formula|OTHER: Dietary Advise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Two Time a Week vs. Five Time a Week Blood Flow Restriction Training Program for the Lower Extremity.
Status: UNKNOWN
Conditions: Blood Flow Restriction Training
Interventions: OTHER: 5x a week BFR training group|OTHER: 2x a week BFR training group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Low-Dose Total Lymphoid Irradiation in Treating Patients With Refractory Chronic Graft-versus-Host Disease After Donor Stem Cell Transplant
Status: TERMINATED
Conditions: Graft Versus Host Disease
Interventions: RADIATION: total nodal irradiation|OTHER: laboratory biomarker analysis|OTHER: questionnaire administration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study of SPH3127 in the Treatment of Mild to Moderate Ulcerative Colitis
Status: RECRUITING
Conditions: Mild to Moderate Ulcerative Colitis
Interventions: DRUG: SPH3127 Tablets with Dose A|DRUG: SPH3127 Tablets with Dose B|DRUG: SPH3127 Tablets placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I Vandetanib Plus Capecitabine, Oxaliplatin and Bevacizumab for Metastatic Colorectal Cancer
Status: COMPLETED
Conditions: Anal, Colon, and Rectal Cancers|Colorectal Neoplasms|Colon/Rectal Cancer
Interventions: DRUG: Vandetanib|DRUG: Capecitabine|DRUG: Oxaliplatin|DRUG: Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sub-chronic Effects of 5-hydroxytryptophan on Mood and Emotional Processing in Healthy Volunteers
Status: COMPLETED
Conditions: Mood
Interventions: DIETARY_SUPPLEMENT: 5-Hydroxytryptophan|DIETARY_SUPPLEMENT: Pharmaceutical grade silica
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Quinagolide Vaginal Ring on Lesion Reduction Assessed by MRI in Women With Endometriosis/Adenomyosis
Status: COMPLETED
Conditions: Endometriosis
Interventions: DRUG: Quinagolide 1080 µg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PEG-Electrolyte Solution (FORTRANS®) With Mentholyptus Drops (Halls®) Versus Reduced Volume Ascorbic Acid Supplemented PEG-Electrolyte (MoviPrep®) in Colonoscopy Preparation
Status: COMPLETED
Conditions: Bowel Cleansing in Preparation for Colonoscopy
Interventions: OTHER: preparation cleaning solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SCREENING
Clinical trial: Suprachoroidal Sustained-Release OXU-001 Compared to Intravitreal Ozurdex® in the Treatment of Diabetic Macular Edema
Status: ACTIVE_NOT_RECRUITING
Conditions: Diabetic Macular Edema
Interventions: DRUG: OXU-001|DEVICE: Semi-automated suprachoroidal illuminated microcatheter|DRUG: Ozurdex® Ophthalmic Intravitreal Implant
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Protective Ventilation With Carbon Dioxide (CO2) -Removal Technique in Patients With Adult Respiratory Distress Syndrome (ARDS)
Status: COMPLETED
Conditions: Adult Respiratory Distress Syndrome
Interventions: PROCEDURE: protective ventilation with CO2 removal technique
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Single- vs. Double-Bundle ACL Reconstruction
Status: COMPLETED
Conditions: Anterior Cruciate Ligament Injury
Interventions: PROCEDURE: Anatomic Double-Bundle ACL Reconstruction|PROCEDURE: Anatomic Single-Bundle ACL Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Topical Ozone on The Healing Diabetic Foot Ulcer
Status: NOT_YET_RECRUITING
Conditions: Wound Heal|Diabetic Foot Ulcer|Ozone
Interventions: DEVICE: Topical ozone therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Acute Intake of Flavanols on Cerebral Oxygenation and Cognition in Young Male Adults
Status: COMPLETED
Conditions: Healthy
Interventions: DIETARY_SUPPLEMENT: High-flavanol cocoa powder|DIETARY_SUPPLEMENT: Low-flavanol cocoa powder
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia|Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Interventions: DRUG: Asparaginase|DRUG: Cyclophosphamide|DRUG: Cytarabine|DRUG: Dasatinib|DRUG: Daunorubicin Hydrochloride|DRUG: Dexamethasone|DRUG: Etoposide|BIOLOGICAL: Filgrastim|DRUG: Hydrocortisone Sodium Succinate|DRUG: Ifosfamide|OTHER: Laboratory Biomarker Analysis|DRUG: Leucovorin Calcium|DRUG: Mercaptopurine|DRUG: Methotrexate|DRUG: Methylprednisolone|DRUG: Pegaspargase|DRUG: Prednisone|RADIATION: Radiation Therapy|DRUG: Vincristine Sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Social Forces to Improve Statin Adherence (Study A)
Status: COMPLETED
Conditions: Medication Adherence|High Blood Pressure|Diabetes
Interventions: BEHAVIORAL: Medication Adherence Partner|DEVICE: Electronic pill bottle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Patient Satisfaction and OHRQoL In Removable Versus Fixed Implant Prostheses
Status: COMPLETED
Conditions: Completely Edentulous Patients
Interventions: PROCEDURE: maxillary and mandibular telescopic retained overdentures supported by 4 implants|PROCEDURE: maxillary and mandibular screw retained hybrid prostheses supported by 4 implants
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT