pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Bridge-Enhanced ACL Repair-Safety Study (BEAR Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Anterior Cruciate Ligament Injury|Anterior Cruciate Ligament Tear
Interventions: DEVICE: ACL Repair with MIACH Scaffold|PROCEDURE: Standard ACL Reconstruction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DEVICE_FEASIBILITY
Clinical trial: TB Nutrition, Immunology and Epidemiology
Status: COMPLETED
Conditions: Mycobacterium Tuberculosis
Interventions: DRUG: Folic Acid|DRUG: Micronutrients: Vitamins B1, B2, B6, Niacin, B12, C, E.|DRUG: Selenium|DRUG: Vitamin A
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer
Status: RECRUITING
Conditions: Localized Renal Pelvis and Ureter Urothelial Carcinoma|Malignant Solid Neoplasm|Metastatic Malignant Neoplasm in the Bone|Metastatic Malignant Neoplasm in the Soft Tissues|Metastatic Renal Pelvis and Ureter Urothelial Carcinoma|Recurrent Bladder Carcinoma|Recurrent Prostate Carcinoma|Recurrent Renal Pelvis and Ureter Urothelial Carcinoma|Stage IV Bladder Cancer AJCC v7|Stage IV Bladder Urothelial Carcinoma AJCC v7|Stage IV Prostate Cancer AJCC v7
Interventions: OTHER: Cytology Specimen Collection Procedure|OTHER: Laboratory Biomarker Analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Safety and Efficacy Study of IPG Patient With Home Monitoring
Status: COMPLETED
Conditions: Bradyarrhythmia
Interventions: DEVICE: BIOTRONIK Home Monitoring System|DEVICE: BIOTRONIK Home Monitoring System with In-office Follow-up
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Information About the Benefits and Harms of Mammography on Women's Decision Making
Status: COMPLETED
Conditions: Breast Cancer Screening
Interventions: OTHER: Decision aid for breast cancer screening|OTHER: Standard leaflet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: SOX-based CRT for Esophageal Cancer.
Status: WITHDRAWN
Conditions: Esophageal Cancer
Interventions: DRUG: Oxaliplatin|DRUG: S-1 capsule|RADIATION: Intensity modulated radiotherapy (IMRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Comparison of Hyaluronidase and Dexametasone in Reduction of Postoperative Edema
Status: COMPLETED
Conditions: Edema|Pain|Trismus|Infection, Surgical Site
Interventions: DRUG: Hyaluronidase Injection mesomedica|DRUG: Dexamethasone dekort
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Study to Assess the Safety, Tolerability, and Pharmacokinetics of PXL770 in Healthy Subjects.
Status: COMPLETED
Conditions: NASH - Nonalcoholic Steatohepatitis
Interventions: DRUG: PXL770
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Brain Aging and Treatment Response in Geriatric Depression
Status: COMPLETED
Conditions: Mild Cognitive Impairment (MCI)|Depression
Interventions: DRUG: Escitalopram|DRUG: Memantine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Combined PD-1 and CCR5 Inhibition for the Treatment of Refractory Microsatellite Stable mCRC
Status: COMPLETED
Conditions: Metastatic Colorectal Cancer|MSS
Interventions: BIOLOGICAL: Pembrolizumab|DRUG: Maraviroc
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: On-Eye Evaluation of Contact Lens Rotation Marks
Status: COMPLETED
Conditions: Refractive Error
Interventions: DEVICE: Delefilcon A spherical contact lens with molded marks|DEVICE: Etafilcon A toric contact lens
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose:
Clinical trial: Multiple Ascending Oral Dose 14-Day Trial of LHF-535 in Healthy Participants
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: LHF-535
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Vial Kit
Status: COMPLETED
Conditions: Neovascular Age-related Macular Degeneration (nAMD)
Interventions: DRUG: SOK583A1
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Detoxification From the Lipid Tract
Status: COMPLETED
Conditions: COVID-19 Vaccine Adverse Reaction
Interventions: DEVICE: electroencephalogram biofeedback|DEVICE: electrical brain stimulation|DEVICE: ultra-low frequency transcranial magnetic stimulation|DRUG: Sertraline Hydrochloride|DRUG: Clonazepam|DRUG: Alprazolam|DRUG: Metoprolol|DRUG: Olanzapine|DRUG: Pravastatin Sodium 20 MG|DRUG: Sacubitril Valsartan Sodium Hydrate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Optimized Perioperative Analgesia Reduces the Prevalence and the Intensity of Phantom Pain in Lower Limb Amputation
Status: COMPLETED
Conditions: Phantom Limb Pain
Interventions: PROCEDURE: perioperative epidural catheter
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Description of the Cystatin C as an Early Nephrotoxic Bio-marker in Pediatric Oncology
Status: COMPLETED
Conditions: Kidney Diseases
Interventions: DIETARY_SUPPLEMENT: Urinary and blood sample for Cystatine dosage
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy
Status: UNKNOWN
Conditions: Hematopoietic/Lymphoid Cancer|Adult Acute Lymphoblastic Leukemia in Remission|B-cell Adult Acute Lymphoblastic Leukemia|B-cell Chronic Lymphocytic Leukemia|Prolymphocytic Leukemia|Recurrent Adult Diffuse Large Cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Grade 3 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Refractory Chronic Lymphocytic Leukemia|Stage III Adult Diffuse Large Cell Lymphoma|Stage III Chronic Lymphocytic Leukemia|Stage III Grade 1 Follicular Lymphoma|Stage III Grade 2 Follicular Lymphoma|Stage III Grade 3 Follicular Lymphoma|Stage III Mantle Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma|Stage IV Chronic Lymphocytic Leukemia|Stage IV Grade 1 Follicular Lymphoma|Stage IV Grade 2 Follicular Lymphoma|Stage IV Grade 3 Follicular Lymphoma|Stage IV Mantle Cell Lymphoma
Interventions: BIOLOGICAL: anti-CD20-CAR vector-transduced autologous T cells|OTHER: genetically engineered lymphocyte therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Serum Ceftazidime Concentrations in Hemodialysis Patients
Status: UNKNOWN
Conditions: Bacterial Infections|Ceftazidime|Renal Failure Chronic Requiring Hemodialysis
Interventions: DRUG: Drug bood sampling
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
Status: RECRUITING
Conditions: Imipramine|Photodynamic Therapy|Actinic Keratosis
Interventions: DRUG: Imipramine|OTHER: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Efficacy of Convection-based HDF Compare With Diffusion-based HD in Sepsis-associated AKI
Status: RECRUITING
Conditions: Primary Outcome : Compare Percent CRP Reduction|Secondary Outcome : 30-day Mortality, Renal Recovery, Length of Hospital Stay
Interventions: DEVICE: Convection-based Hemodiafiltration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Mifepristone Induction for Fetal Demise
Status: TERMINATED
Conditions: Intrauterine Fetal Demise|Fetal Death
Interventions: DRUG: Mifepristone|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 1 Pharmacokinetic Study of Single-Ascending Doses of Intravenous Nafithromycin in Healthy Adult Subjects
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Nafithromycin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of CS1001 in Combination With Regorafenib in Patients With Advanced or Refractory Solid Tumors
Status: COMPLETED
Conditions: Advanced Refractory Solid Tumors
Interventions: DRUG: CS1001|DRUG: Regorafenib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigation of The Effect of Pelvic Floor Exercise Programme in Elderly.
Status: COMPLETED
Conditions: Pelvic Floor Muscle Weakness|Urinary Incontinence in Old Age|Sexual Dysfunction|Quality of Life
Interventions: OTHER: Exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012)
Status: COMPLETED
Conditions: Ankylosing Spondylitis
Interventions: BIOLOGICAL: Golimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pre-emptive Prevention for Patients at High Risk for Hospital-onset Clostridioides Difficile
Status: RECRUITING
Conditions: C. Difficile
Interventions: OTHER: Arm 1: Routine care|OTHER: Arm 2: Preemptive C. difficile infection prevention bundle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes.
Status: COMPLETED
Conditions: Diabetes|Diabetes Mellitus, Type 2
Interventions: DRUG: semaglutide|DRUG: Dulaglutide
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: High Dosage Esomeprazole and Baclofen for Therapy of Gastroesophageal Reflux Disease
Status: COMPLETED
Conditions: Patients With Persistent Objectified Gastroesophageal Reflux and Reflux-Associated Symptoms Despite PPI-Therapy With 40mg Esomeprazole
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation
Status: COMPLETED
Conditions: Diabetic Retinopathy|Diabetic Macular Edema|DME
Interventions: DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Safety, Pharmacodynamics, and Pharmacokinetics After Multiple Different Oral Doses of BIIB 722 CL Tablets in Healthy Volunteers
Status: TERMINATED
Conditions: Healthy
Interventions: DRUG: BIIB 722 CL|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of High and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcome in Patients With AIS
Status: COMPLETED
Conditions: Ischemic Stroke
Interventions: DRUG: Simvastatin 10 mg|DRUG: Simvastatin 40 mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: A Study for Patients With Erectile Dysfunction to Test Whether Tadalafil Taken Once a Day Can Better Improve Psychological Outcomes.
Status: COMPLETED
Conditions: Erectile Dysfunction
Interventions: DRUG: tadalafil once a day [T(OaD)]|DRUG: sildenafil citrate as needed [S(PRN)]|DRUG: tadalafil as needed [T(PRN)]
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Vaccination Against Influenza to Prevent Cardiovascular Events After Acute Coronary Syndromes
Status: COMPLETED
Conditions: Acute Coronary Syndrome
Interventions: BIOLOGICAL: Double Dose Quadrivalent Influenza Vaccine|BIOLOGICAL: Standard Dose Quadrivalent Influenza Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Bexarotene Combined With Radiotherapy in People With Mycosis Fungoides
Status: RECRUITING
Conditions: Cutaneous T-cell Lymphoma
Interventions: DRUG: Bexarotene|RADIATION: Total Skin Electron Beam (TSEB)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clomiphene Citrate Plus Cabergoline in Treatment of Polycystic Ovary Syndrome
Status: UNKNOWN
Conditions: Female Reproductive Problem
Interventions: DRUG: Clomiphene citrate|DRUG: Cabergoline|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effect of DBcare, a Food Supplement on Diabetes Control
Status: COMPLETED
Conditions: Diabetes Mellitus, Non-insulin Dependant|Diabetes Mellitus Type 2|Diabetes Mellitus, on Oral Hypoglycemic Treatment|Adult Type Diabetes Mellitus
Interventions: DIETARY_SUPPLEMENT: DBCARE|DIETARY_SUPPLEMENT: DBCARE
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Dose Increase Finding Study of Doxorubicin Hydrochloride Liposome Injection for Patients With Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: DRUG: Doxorubicin Hydrochloride Liposome Injection|DRUG: Cyclophosphamide|DRUG: docetaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cognitive Training After Stroke : Effects and Mechanisms
Status: COMPLETED
Conditions: Stroke
Interventions: DEVICE: Transcranial direct current stimulation (tDCS)|DEVICE: Sham Transcranial direct current stimulation (tDCS)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Status: NOT_YET_RECRUITING
Conditions: Age-related Macular Degeneration (AMD)|Geographic Atrophy (GA)
Interventions: DRUG: Pozelimab|DRUG: Cemdisiran|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Effectiveness, Safety, and Palatability Study of Pancrelipase Microtablets in Infants and Toddlers With Cystic Fibrosis and Fat Malabsorption
Status: COMPLETED
Conditions: Cystic Fibrosis|Steatorrhea
Interventions: DRUG: Pancrelipase microtablets
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Cross-over Study to Prove Bioequivalence Between Two Oral Formulations of Levonorgestrel 1.5 mg
Status: COMPLETED
Conditions: Contraceptives, Postcoital
Interventions: DRUG: Levonorgestrel Emergency Pill (BAY86-5028)|DRUG: Postinor 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Study of Anti-atherosclerotic Activity of Inflaminat in Asymptomatic Participants With Subclinical Atherosclerosis
Status: UNKNOWN
Conditions: Carotid Atherosclerosis
Interventions: DIETARY_SUPPLEMENT: Inflaminat|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: PREVENTION
Clinical trial: "POWER2DM Evaluation Campaign"
Status: COMPLETED
Conditions: Type1 Diabetes Mellitus|Type2 Diabetes Mellitus|Diabetes Mellitus|Health Behavior|Self Efficacy
Interventions: DEVICE: POWER2DM system|OTHER: Usual care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Intranasal Vasopressin on Cooperative Behavior in Schizophrenia
Status: COMPLETED
Conditions: Schizophrenia
Interventions: DRUG: Vasopressins|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: Physical Therapies in the Decongestive Treatment of Lymphedema
Status: COMPLETED
Conditions: Primary Lymphedema|Secondary Lymphedema
Interventions: OTHER: Manual Lymphatic Drainage (MLD)|DEVICE: Generic intermittent pneumatic compression Device (IPC)|OTHER: multilayer, multicomponent bandages (MB)|DEVICE: Lymphapress-Plus(TM) device (LPD)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mesenchymal Stem Cells for Age-Related Frailty
Status: WITHDRAWN
Conditions: Frailty
Interventions: DRUG: Mesenchymal Stem Cells (MSCs)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study to Test How Healthy Men Tolerate Different Doses of BI 1595043
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: BI 1595043|DRUG: Placebo|DRUG: Midazolam
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Raptiva and Sirolimus in Islet Transplantation for Type 1 Diabetes
Status: TERMINATED
Conditions: Type 1 Diabetes Mellitus|Hypoglycemia
Interventions: BIOLOGICAL: Allogeneic islets of Langerhans transplant|DRUG: Raptiva|DRUG: Sirolimus|DRUG: anti-thymocyte globulin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Almonertinib Plus Chemotherapy as First-line Treatment in Patients With EGFR Concomitant Non-EGFR Driver Gene Mutant, Locally Advanced or Metastatic NSCLC
Status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Interventions: DRUG: Almonertinib|DRUG: Almonertinib plus carboplatin and pemetrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Strategy to Cope Pain and Discomfort in Mammography
Status: UNKNOWN
Conditions: Anxiety|Pain|Discomfort
Interventions: DRUG: Paracetamol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Digital Foot Check by Using the D-Foot, a New Software
Status: COMPLETED
Conditions: Diabetic Foot|Diabetic Foot Ulcer|Diabetic Foot Ulcer Neuropathic|Neuropathy;Peripheral|Foot Deformities|Foot Callus
Interventions: DIAGNOSTIC_TEST: D-Foot
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass
Status: COMPLETED
Conditions: Blood Coagulation Disorders
Interventions: DEVICE: method of returning residual CPB blood ( Hemobag®)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Efficacy of Tooth Bleaching With 35% and 6% Hydrogen Peroxide in Primary Dentition
Status: NOT_YET_RECRUITING
Conditions: Sensitivity, Tooth
Interventions: PROCEDURE: Tooth Bleaching with Whiteness HP Automixx 35%|PROCEDURE: Tooth Bleaching with Whiteness HP Automixx 6%
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sevoflurane Associated With Oral Midazolam and Ketamine for Dental Sedation
Status: COMPLETED
Conditions: Dental Anxiety
Interventions: DRUG: Midazolam, Ketamine and Sevoflurane|DRUG: Midazolam and Ketamine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Blinded Efficacy and Safety Study of CAL02 IV Plus SOC in Subjects With Severe Community-Acquired Bacterial Pneumonia
Status: RECRUITING
Conditions: Pneumonia, Bacterial
Interventions: DRUG: CAL02|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Azacitidine, and Thalidomide in Higher Risk MDS (Myelodysplastic Syndrome)
Status: UNKNOWN
Conditions: Myelodysplastic Syndrome
Interventions: DRUG: 5-aza-cytidine and Thalidomide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: This Study Contains an Active Drug Treatment Group With Mometasone Furoate Nasal Spray and a Placebo (Dummy) Treatment Group for Seasonal Allergic Rhinitis (SAR). (Study P05073)(COMPLETED)
Status: COMPLETED
Conditions: Seasonal Allergic Rhinitis
Interventions: DRUG: Mometasone Furoate Nasal Spray|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: New Clinical End-points in Patients With Primary Sjögren's Syndrome
Status: RECRUITING
Conditions: Primary Sjögren's Syndrome (pSS)
Interventions: DRUG: Hydroxychloroquine 400mg/d|DRUG: Leflunomide 20mg/d|DRUG: Mycophenolate mofetil 2000mg/d|DRUG: Placebo of Hydroxychloroquine 400mg/d|DRUG: Placebo of Leflunomide 20mg/d|DRUG: Placebo of Mycophenolate mofetil 2000mg/d
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)
Status: ACTIVE_NOT_RECRUITING
Conditions: Plaque Psoriasis
Interventions: DRUG: JNJ-77242113|DRUG: JNJ-77242113 Matching Placebo|DRUG: Deucravacitinib|DRUG: Deucravacitinib Matching Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Abdominothoracic Muscular Tone in Functional Dyspepsia
Status: RECRUITING
Conditions: Dyspepsia
Interventions: BEHAVIORAL: Abdominothoracic biofeedback
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: OTHER
Clinical trial: 4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy
Status: RECRUITING
Conditions: Breast Cancer|Radiation-Induced Vascular Disease|Left Anterior Descending Coronary Artery Stenosis|Radiotherapy Side Effect|Cardiac Ischemia|Left Sided Breast Cancer|LAD (Left Anterior Descending) Coronary Artery Stenosis
Interventions: OTHER: Respiratory gating
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Multiple Dose Study Of PF-04937319 In Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2|NIDDM
Interventions: DRUG: PF-04937319|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Evaluation of Therapy™ Cool Path™ Duo Cardiac Ablation System for the Treatment of Typical Atrial Flutter (AFL)
Status: COMPLETED
Conditions: Typical Atrial Flutter
Interventions: DEVICE: Therapy Cool Path Duo
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Catheter Contact Force and Electrograms
Status: COMPLETED
Conditions: Atrial Fibrillation
Interventions: DEVICE: THERMOCOOL® SMARTTOUCH™ Catheter (including Surround Flow)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: DIAGNOSTIC
Clinical trial: Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease
Status: TERMINATED
Conditions: Diabetes Complications|Fatty Liver
Interventions: DRUG: exenatide
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluating the Effectiveness of Mobile Self-guided Psychological Interventions to Reduce Relapse in Substance Use Disorder
Status: RECRUITING
Conditions: Substance Use Disorders|Addiction, Alcohol|Addiction, Substance
Interventions: OTHER: Mobile app-based self-guided interventions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial of Ebola Vaccines cAd3-EBO, cAd3-EBOZ and MVA-EbolaZ in Healthy Adults in Uganda
Status: COMPLETED
Conditions: Hemorrhagic Fever, Ebola
Interventions: BIOLOGICAL: cAd3-EBOZ|BIOLOGICAL: cAd3-EBO|BIOLOGICAL: MVA-EbolaZ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder
Status: COMPLETED
Conditions: Smoking|Bipolar Disorder
Interventions: BEHAVIORAL: Experimental plus Nicotine Replacement Therapy|BEHAVIORAL: Control plus Nicotine Replacement Therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of an L-Carnitine-Containing Peritoneal Dialysis (PD) Solution on Insulin Sensitivity in Diabetic Patients on Continuous Ambulatory Peritoneal Dialysis (CAPD)
Status: WITHDRAWN
Conditions: End Stage Renal Disease|Diabetes
Interventions: DRUG: PD Solution|DRUG: PD solution containing L-carnitine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer
Status: RECRUITING
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions: DRUG: Nivolumab|DRUG: Relatlimab|DRUG: Ipilimumab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification
Status: UNKNOWN
Conditions: Metabolic Bone Disorder
Interventions: DIETARY_SUPPLEMENT: K2 vitamin|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Safety Study of a Monoclonal Antibody to Respiratory Syncytial Virus (RSV) in Children Hospitalized With RSV Infection
Status: COMPLETED
Conditions: Respiratory Syncytial Virus Prophylaxis
Interventions: BIOLOGICAL: Motavizumab|BIOLOGICAL: Motavizumab|BIOLOGICAL: Motavizumab|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Neoadjuvant Pemetrexed, Carboplatin and Bevacizumab in Unresectable, Locally Advanced Lung Adenocarcinoma
Status: COMPLETED
Conditions: Lung Cancer
Interventions: DRUG: Neoadjuvant Bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Uterine Leiomyoma Treatment With Radiofrequency Ablation (ULTRA) Registry
Status: ACTIVE_NOT_RECRUITING
Conditions: Uterine Fibroids
Interventions: PROCEDURE: Radiofrequency ablation of fibroids|PROCEDURE: Myomectomy of fibroids
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Bioequivalence of 2 Formulations of TKI258 in Patients With Advanced Solid Tumors
Status: COMPLETED
Conditions: Advanced Solid Tumors|Excluding Breast Cancer
Interventions: DRUG: TKI258
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Central Nervous System Effects Following Infusion of Diphenhydramine Using Pharmacokinetic and Pharmacodynamic Modeling
Status: TERMINATED
Conditions: Central Nervous System Effects of Diphenhydramine|Pharmacokinetics of Diphenhydramine
Interventions: DRUG: DiphenhydrAMINE Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: A Long-term Safety Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes
Status: ACTIVE_NOT_RECRUITING
Conditions: Type 2 Diabetes
Interventions: DRUG: Orforglipron
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VIS954 in Healthy Adult Participants
Status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Volunteers
Interventions: BIOLOGICAL: VIS954|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures
Status: TERMINATED
Conditions: Bacteraemia|Endocarditis
Interventions: DRUG: Amoxicillin|DRUG: Amoxicillin-Potassium Clavulanate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
Status: RECRUITING
Conditions: Opioid-use Disorder|Neonatal Abstinence Syndrome|Pregnancy, High Risk|Alcohol Use Disorder
Interventions: OTHER: Pharmacokinetic analysis|OTHER: Safety and Efficacy|GENETIC: Genetic and epigenetic analysis|OTHER: Breast milk analysis
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk
Status: RECRUITING
Conditions: Scleroderma|Systemic Sclerosis
Interventions: DRUG: clopidogrel treatment|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Synaptic Density and Progression of Parkinson's Disease.
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: OTHER: 11C-UCB-J PET-CT|OTHER: 18F-PE2I PET-MR
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Dorsal Root Ganglion Stimulation for the Management of Painful Intractable Small Fibre Neuropathy:
Status: UNKNOWN
Conditions: Neuropathy Small Fibre
Interventions: DEVICE: Spinal Modulation Axium™
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ONSD According to the Position During Laparoscopy
Status: COMPLETED
Conditions: Cholecystitis|Ovarian Cyst|Ovarian Cancer|Uterine Myoma|Cervical Cancer
Interventions: DRUG: Desflurane|DRUG: Remifentanil|DEVICE: Ultrasonographic measurement of ONSD|PROCEDURE: Mechanical ventilation|PROCEDURE: Trendelenburg position - 30 degree|PROCEDURE: Reverse Trendelenburg position - 30 degree
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Surgical Management of Cerebral Arteriovenous Malformations Within Hybrid Operation Room
Status: COMPLETED
Conditions: Intracranial Arteriovenous Malformations
Interventions: PROCEDURE: hybrid operating techniques
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Sleeve Gastrectomy With Uncut Jejunal Bypass (SG-uncut JJB) Verus Sleeve Gastrectomy in Obese Patients
Status: UNKNOWN
Conditions: Excessive Weight Loss|Total Weight Loss|Sleeve Gastrectomy|Jejunojejunal Bypass|Uncut
Interventions: PROCEDURE: SG-JJB
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure
Status: COMPLETED
Conditions: Primary Ovarian Insufficiency|Premature Ovarian Failure|Infertility
Interventions: BIOLOGICAL: human amniotic epithelial cells (hAECs) transplantation
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Combination Trial of Copaxone Plus Estriol in Relapsing Remitting Multiple Sclerosis (RRMS)
Status: COMPLETED
Conditions: Relapsing Remitting Multiple Sclerosis
Interventions: DRUG: Estriol|DRUG: Placebo|DRUG: Copaxone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: A Safety and Efficacy Study of Pracinostat and Azacitidine in Patients With High Risk Myelodysplastic Syndromes
Status: TERMINATED
Conditions: Myelodysplastic Syndromes
Interventions: DRUG: Pracinostat|DRUG: Azacitidine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Opioid Free Anesthesia in Total Hip Arthroplasty
Status: COMPLETED
Conditions: Primary Total Hip Arthroplasty
Interventions: DRUG: Sufentanil|DRUG: Dexmedetomidine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Single Ascending Dose Study of CD101 IV in Healthy Subjects
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: CD101 IV|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Community to Clinic Linkage Program at SFGH
Status: COMPLETED
Conditions: Family's Connection to Community Resources and Public Benefits|Caregiver Satisfaction and Connectedness to Clinic|Child Health Care Status
Interventions: OTHER: Pediatric Primary Care Intervention|OTHER: Pediatric Urgent Care Intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral Drugs
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Narlaprevir|DRUG: Ritonavir|DRUG: Tenofovir Disoproxil Fumarate|DRUG: Raltegravir
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Antiseptic Outcome of Traditional Hand Scrubbing Versus Hand Rubbing in Surgical Room
Status: COMPLETED
Conditions: Hand Disinfection
Interventions: DEVICE: ethyl alcochol, chlorhexidine and moisturizers|DEVICE: chlorhexidine|DEVICE: povidone-iodine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Tranexamic Acid Plus Buccal Misoprostol on Blood Loss During and After Cesarean Delivery
Status: COMPLETED
Conditions: Cesarean Section Complications
Interventions: DRUG: Oxytocin|DRUG: Tranexamic acid plus misoprostol|DRUG: misoprostol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Study of ALLN-177 in Patients Aged 12 Years or Older With Enteric or Primary Hyperoxaluria and Hyperoxalemia
Status: COMPLETED
Conditions: Enteric Hyperoxaluria|Primary Hyperoxaluria|Hyperoxalemia
Interventions: DRUG: ALLN-177
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Rituximab and Interleukin-2 in Treating Patients With Relapsed or Refractory Intermediate- or High-Grade Non-Hodgkin's Lymphoma
Status: COMPLETED
Conditions: Lymphoma
Interventions: BIOLOGICAL: aldesleukin|BIOLOGICAL: rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
Status: RECRUITING
Conditions: Brain Damage|Postoperative|Surgery-Complications
Interventions: DIAGNOSTIC_TEST: Mini Mental State Examination(MMSE),Montreal Cognitive Assessment ( MoCA),S100B ( protein S100 subunit beta) ,GFAP ( glial fibrillary acidic protein ),NSE ( neuron-specific enolase )
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension
Status: COMPLETED
Conditions: Glaucoma, Open-Angle|Ocular Hypertension
Interventions: DRUG: Bimatoprost SR|DRUG: Active Comparator: Timolol 0.5%|OTHER: Sham: Applicator Without Needle|DRUG: Timolol Vehicle (placebo)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: DMT210 Topical Gel in the Treatment of Acne Rosacea
Status: COMPLETED
Conditions: Acne Rosacea
Interventions: DRUG: DMT210 Topical Gel 5%|OTHER: Vehicle Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Use of Impedance Cardiography and Applanation Tonometry for Prediction of the Antihypertensive Effect of Two Drugs
Status: COMPLETED
Conditions: Arterial Stiffness|Ambulatory Blood Pressure Monitoring
Interventions: DRUG: Olmesartan|DRUG: Chlorthalidone
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Urothelial Carcinoma|Bladder Cancer
Interventions: DRUG: Cabozantinib|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Phase II Trial of Neoadjuvant Pembrolizumab for Patients With Early Stage Gastroesophageal Adenocarcinoma
Status: TERMINATED
Conditions: Gastroesophageal Junction Adenocarcinoma|Gastric Adenocarcinoma|Esophageal Adenocarcinoma
Interventions: DRUG: Pembrolizumab Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization
Status: RECRUITING
Conditions: Substance Use Disorders|Opioid-use Disorder|Chronic Pain
Interventions: DRUG: BUP microdose induction|DRUG: TAU|BEHAVIORAL: Linkage to outpatient BUP treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations
Status: RECRUITING
Conditions: Advanced or Metastatic Solid Tumors
Interventions: DRUG: Naporafenib|DRUG: Trametinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: FCR Plus Sargramostim (GM-CSF) as Frontline Therapy for Symptomatic Chronic Lymphocytic Leukemia
Status: COMPLETED
Conditions: Chronic Lymphocytic Leukemia
Interventions: DRUG: Cyclophosphamide|DRUG: Fludarabine|DRUG: Sargramostim|DRUG: Rituximab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Venetoclax Add in Combination With Fludarabine, Cyratabine and Idarubicine in Induction for Acute Myelid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Factors Responsible for the Effectiveness of the Lund De-airing Technique
Status: COMPLETED
Conditions: Complication of Surgical Procedure
Interventions: PROCEDURE: Open pleurae & conventional filling of heart|PROCEDURE: Intact pleurae & staged filling of heart
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Study to Assess the Effect of Cefiderocol on the Pharmacokinetics (PK) of Midazolam in Healthy Participants
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: Midazolam|DRUG: Cefiderocol
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Photobiomodulation on Pain Control After Placement of Elastomeric Spacers.
Status: ACTIVE_NOT_RECRUITING
Conditions: Inflammation
Interventions: RADIATION: Photobiomodulation|OTHER: Simulation of Photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients
Status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Rhinosinusitis With Nasal Polyps|Asthma
Interventions: DRUG: Dupilumab|DRUG: Omalizumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Mobility in Atypical Parkinsonism: a Trial of Physiotherapy
Status: RECRUITING
Conditions: Multiple System Atrophy, Parkinson Variant (Disorder)|Parkinson Disease|Progressive Supranuclear Palsy
Interventions: OTHER: Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Correlation Between Vitamin A / E Levels and Preeclampsia
Status: UNKNOWN
Conditions: Preeclampsia|Vitamin A Deficiency|Vitamin E Deficiency
Interventions: DRUG: Vitamin A|DRUG: Vitamin E
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Characteristic Analysis and Surgical Exploration for Acetabular Roof Fractures: Multicenter Retrospective Cohort Study
Status: WITHDRAWN
Conditions: Acetabular Fracture
Interventions: PROCEDURE: KL, Iliofemoral, Ilioinguinal, Iliac fossa and combined approaches
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: YTS104 Cell Injection for the Treatment of Relapsed or Refractory Multiple Myeloma
Status: NOT_YET_RECRUITING
Conditions: Relapsed or Refractory Multiple Myeloma
Interventions: BIOLOGICAL: YTS104 Cells injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Cytokine Guided Risk Stratification and Treatment in Pediatric Hemophagocytic Lymphohistiocytosis
Status: RECRUITING
Conditions: Hemophagocytic Lymphohistiocytoses|Cytokine Storm
Interventions: DRUG: Dexamethasone|DRUG: Etoposide|DRUG: Ruxolitinib
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Apraglutide on Gastric Emptying
Status: COMPLETED
Conditions: Healthy Subjects
Interventions: DRUG: Apraglutide|DRUG: Placebo|DRUG: Acetaminophen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: Meditation in Veterans With PTSD and Mild TBI
Status: COMPLETED
Conditions: Stress Disorders, Post-Traumatic|Concussion, Mild
Interventions: BEHAVIORAL: Inner Resources for Veterans (IRV)|BEHAVIORAL: Essential Skills therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT