pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: TAK-659 in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Status: TERMINATED
Conditions: Diffuse Large B-cell Lymphoma
Interventions: DRUG: TAK-659
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement
Status: COMPLETED
Conditions: Resorbed Alveolar Ridge Prior to Dental Implant Insertion
Interventions: DEVICE: Bio-Oss (by Geistlich)|DEVICE: BondBone (by Augma)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Clinical Study of Acupuncture in the Treatment of Diabetic Peripheral Neuropathy
Status: RECRUITING
Conditions: Diabetic Peripheral Neuropathy
Interventions: OTHER: Acupuncture|OTHER: Sham Acupuncture
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: NUTritional Impact of a Hypocaloric Hyperprotein Diet Before Obesity Surgery
Status: NOT_YET_RECRUITING
Conditions: Diet, Healthy|Obesity, Visceral|Bariatric Surgery Candidate
Interventions: DIETARY_SUPPLEMENT: With low-calorie, high-protein diet|DIETARY_SUPPLEMENT: Without low-calorie, high-protein diet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Investigating the Tolerability and Feasibility of tVNS Following aSAH
Status: RECRUITING
Conditions: Subarachnoid Haemorrhage From Cerebral Aneurism Rupture
Interventions: DEVICE: Transcutaneous Vagus Nerve Stimulation|DEVICE: Sham Transcutaneous Vagus Nerve Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: OTHER
Clinical trial: A Study of Efficacy and Safety of Hemay005 Tablets in Patients With Behçet's Disease
Status: RECRUITING
Conditions: Behçet's Disease
Interventions: DRUG: Hemay005|DRUG: Hemay005|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: Effects of the Bilateral Mandibular Nerve Block (V3) in Mandibular Osteotomy
Status: COMPLETED
Conditions: Mandibular Fracture Trauma|Orthognathic Surgery|Maxillofacial Osteotomy
Interventions: PROCEDURE: Realization of the V3 block in maxillofacial surgeries
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: The Effectiveness of Acupuncture for Delirium in Critically Ill Patients
Status: UNKNOWN
Conditions: Intensive Care Unit Delirium|Delirium|Agitation
Interventions: OTHER: Acupuncture (Press Tack Needle)|OTHER: press tack placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Chair-Based Exercise Training on Exercise Capacity in Patients With Acute Exacerbation of COPD
Status: COMPLETED
Conditions: Acute Exacerbation of COPD
Interventions: OTHER: Treatment group, Chair-Based Exercise Training|OTHER: Control group, Breathing exercise
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: ET-01 in Subjects With Lateral Canthal Lines, LCL-208
Status: COMPLETED
Conditions: Lateral Canthal Lines|Crow's Feet
Interventions: BIOLOGICAL: botulinum toxin, Type A|BIOLOGICAL: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study Comparing Flexible Spectral-Imaging Color Enhancement (FICE) With Olympus Narrow Band Imaging (NBI)
Status: COMPLETED
Conditions: Routine Endoscopy
Interventions: DEVICE: FICE Image Acquisition followed by NBI Image Acquisition
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Comparison Between Outcomes of Pregnant Women Treated With Ferinject vs. Venofer for Iron Deficiency Anemia
Status: NOT_YET_RECRUITING
Conditions: Anemia, Iron Deficiency|Pregnancy Anemia
Interventions: DRUG: Venofer 200 MG Per 10 ML Injection|DRUG: Ferinject
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Ergogenic Properties of Magnesium Supplementation
Status: COMPLETED
Conditions: Exercise Performance|Gut -Microbiota|Mitochondrial Function
Interventions: DIETARY_SUPPLEMENT: ReMag|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Biological Image Guided Antalgic Stereotactic Body Radiotherapy of Bone Metastases
Status: COMPLETED
Conditions: Bone Metastases
Interventions: RADIATION: Conventional Radiotherapy|RADIATION: Biological image-guided radiotherapy with conventional dose.|RADIATION: Biological image-guided SBRT with dose-escalation.
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study
Status: NOT_YET_RECRUITING
Conditions: Community Acquired Pneumonia in Children|Mycoplasma Pneumoniae|Mycoplasma Pneumoniae Pneumonia
Interventions: DRUG: Azithromycin Pfizer®|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: The REACH Study: A Novel Values-Based Intervention to Increase Endocrine Therapy Adherence Among Breast Cancer Survivors
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BEHAVIORAL: Education|BEHAVIORAL: Values
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Efficacy of RTS,S/AS01 Vaccine Against Episodes of Malaria Due to P. Falciparum Infection in Children.
Status: COMPLETED
Conditions: Malaria
Interventions: BIOLOGICAL: GSK malaria vaccine 257049 Vaccine|BIOLOGICAL: Sanofi-Pasteur's Human Diploid Cell Rabies Vaccine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Impact of Local Biopsy to the Endometrium Prior to Controlled Ovarian Stimulation on Clinical Pregnancy
Status: COMPLETED
Conditions: Primary or Secondary Infertility
Interventions: PROCEDURE: biopsy|PROCEDURE: IVF
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence
Status: COMPLETED
Conditions: Alcohol Dependence
Interventions: DRUG: Psilocybin|DRUG: Diphenhydramine|BEHAVIORAL: Motivational Enhancement and Taking Action (META)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Diagnosis of Microaspiration in Intubated Critically Ill Patients: Pepsin vs 99m Technetium
Status: WITHDRAWN
Conditions: Critical Illness
Interventions: RADIATION: 99mTc-Rhenium Sulfide Nanocolloid
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Study of ACUVUE® ADVANCE® PLUS Contact Lenses.
Status: COMPLETED
Conditions: Myopia
Interventions: DEVICE: Acuvue Advance Plus prePQ|DEVICE: Acuvue Advance Plus postPQ
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Survival Study of the Recombinant Human Neuregulin-1β in Subjects With Chronic Heart Failure.
Status: RECRUITING
Conditions: Chronic Heart Failure
Interventions: DRUG: rhNRG-1|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: HomeStyles-Adults of Chinese Heritage
Status: NOT_YET_RECRUITING
Conditions: Healthy Lifestyle|Home Environment Related Disease|Cardiometabolic Disease|Systemic Inflammatory Response|Health Behavior|Dietary Habits|Physical Inactivity|Self Efficacy|Gut Microbiota|Diabetes Mellitus
Interventions: BEHAVIORAL: HomeStyles-China
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Percutaneous Hepatic Perfusion vs. Cisplatin/Gemcitabine in Patients With Intrahepatic Cholangiocarcinoma
Status: UNKNOWN
Conditions: Bile Duct Cancer|Intrahepatic Cholangiocarcinoma
Interventions: COMBINATION_PRODUCT: Melphalan/HDS|DRUG: Cisplatin and Gemcitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Role of Intraoperative Thymoglobulin in Decreasing Ischemia-Reperfusion Injury in Pediatric Heart Transplant Recipients
Status: WITHDRAWN
Conditions: Ischemia Reperfusion Injury|Heart Transplantation
Interventions: DRUG: Anti-Thymocyte Globulin|DRUG: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Intervention for Rural Cancer Patients
Status: NOT_YET_RECRUITING
Conditions: Depression|Quality of Life|Social Support|Sleep|Stress
Interventions: BEHAVIORAL: Stepped collaborative care intervention|BEHAVIORAL: Enhanced Usual Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Combination Chemotherapy With or Without Trastuzumab Followed By an Autologous Stem Cell Transplant and Radiation Therapy in Treating Patients With Stage III or Stage IV Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer
Interventions: BIOLOGICAL: trastuzumab|DRUG: carboplatin|DRUG: cyclophosphamide|DRUG: melphalan|DRUG: thiotepa|PROCEDURE: adjuvant therapy|PROCEDURE: autologous-autologous tandem hematopoietic stem cell transplantation|PROCEDURE: bone marrow ablation with stem cell support|RADIATION: radiation therapy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Nitrous Oxide - Sevoflurane-Remifentanil Interaction
Status: TERMINATED
Conditions: ASA Class I/II Patients Scheduled for Surgery Under General Anesthesia
Interventions: DRUG: remifentanil injected|DRUG: sevoflurane in step up concentration
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Aminotransferase Trends During Prolonged Acetaminophen Dosing
Status: COMPLETED
Conditions: Drug Toxicity|Healthy
Interventions: DRUG: acetaminophen|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose:
Clinical trial: A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction
Status: ENROLLING_BY_INVITATION
Conditions: Wrinkle
Interventions: DEVICE: Defyne Treatment in Nasolabial Fold|DEVICE: RHA3 Treatment in Nasolabial Fold
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Effect of L. Plantarum Probiotic Supplementation on Broccoli Sulforaphane Bioavailability: Randomised Double-blind Placebo-controlled Crossover Study
Status: NOT_YET_RECRUITING
Conditions: Nutrition, Healthy
Interventions: DIETARY_SUPPLEMENT: Broccoli sprouts extract supplementation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Treatment of Severe Infection With Antihyperlipidemia Drug
Status: UNKNOWN
Conditions: Sepsis|Septic Shock
Interventions: DRUG: Alirocumab Injectable Product|DRUG: Saline Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spectacles for Patients With Down Syndrome
Status: COMPLETED
Conditions: Vision, Low
Interventions: DEVICE: Spectacles - Clinically Derived|DEVICE: Spectacles - Metric Technique #1 Derived|DEVICE: Spectacles - Metric Technique #2 Derived
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Feature Assessment Study for Indications Based Programming
Status: COMPLETED
Conditions: Ventricular Tachycardia|Ventricular Flutter|Ventricular Fibrillation|Heart Failure
Interventions: DEVICE: Cognis 100-D, Teligen DR and VR 100 HE
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Impact of a Playful Family Education Strategy With ICT on Childhood Obesity Prevention
Status: NOT_YET_RECRUITING
Conditions: Pediatric Obesity|Childhood Obesity|Childhood Overweight
Interventions: OTHER: Conventional treatment|OTHER: Playful Family Education Strategy|OTHER: Reinforced Playful Family Education Strategy
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: PREVENTION
Clinical trial: Safety and Efficacy of Antidiabetic Drugs in Recently Diagnosed Patients With Type 2 Diabetes
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 2
Interventions: DRUG: Vildagliptin 50 MG|DRUG: Sitagliptin 100mg|DRUG: MetFORMIN 1000 Mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: TREATMENT
Clinical trial: Busulfan, Cyclophosphamide, and Melphalan or Busulfan and Fludarabine Phosphate Before Donor Hematopoietic Cell Transplant in Treating Younger Patients With Juvenile Myelomonocytic Leukemia
Status: COMPLETED
Conditions: Juvenile Myelomonocytic Leukemia
Interventions: PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation|DRUG: Busulfan|DRUG: Cyclophosphamide|DRUG: Fludarabine Phosphate|OTHER: Laboratory Biomarker Analysis|DRUG: Melphalan|DRUG: Mycophenolate Mofetil|OTHER: Pharmacological Study|DRUG: Tacrolimus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: HEart trAnsplantation Registry of piTie-Salpetriere University Hospital
Status: COMPLETED
Conditions: Cardiac Transplant Disorder|Cardiac Death|Heart Failure|Acute Cellular Graft Rejection|Antibody-Mediated Graft Rejection|Cardiac Allograft Vasculopathy|Heart Transplant Rejection|Immune Tolerance
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Restore: Improving Sexual Outcomes of Gay and Bisexual Prostate Cancer Survivors
Status: COMPLETED
Conditions: Prostatic Neoplasm
Interventions: BEHAVIORAL: Restore Rehabilitation Program|BEHAVIORAL: Control
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: An Evaluation of the Efficacy and Safety of AL-46383A Ophthalmic Solution for the Treatment of Adenoviral Conjunctivitis
Status: TERMINATED
Conditions: Adenoviral Conjunctivitis
Interventions: DRUG: AL-46383A Ophthalmic Solution|DRUG: AL-46383A Ophthalmic Solution Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically
Status: UNKNOWN
Conditions: Anesthesia; Reaction
Interventions: PROCEDURE: adductor canal block (ACB)|PROCEDURE: Femoral nerve block (FNB)|DRUG: ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy Study of Bimosiamose Cream to Treat Psoriasis
Status: COMPLETED
Conditions: Psoriasis
Interventions: DRUG: Bimosiamose Cream|DRUG: Placebo Cream
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phenytoin and Driving Safety: A Randomized, Controlled Cross-Over Study
Status: COMPLETED
Conditions: Cognitive Measures|Driving Simulator Performance
Interventions: DRUG: Phenytoin|DRUG: Placebo oral capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study of Mosunetuzumab in People With Follicular Lymphoma
Status: RECRUITING
Conditions: Follicular Lymphoma|Lymphoma
Interventions: DRUG: Mosunetuzumab|DRUG: Zanubrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Stimulus Phase Duration on Discomfort and Electrically Induced Torque of Quadriceps Femoris
Status: COMPLETED
Conditions: Torque|Pain Perception
Interventions: DEVICE: 400 microseconds|DEVICE: 700 microseconds|DEVICE: 1000 microseconds
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose:
Clinical trial: A Study to Evaluate Biomarkers in Moderate to Severe Ulcerative Colitis (UC) Patients Treated With Different Targeted Therapies
Status: RECRUITING
Conditions: Ulcerative Colitis|Inflammatory Bowel Diseases
Interventions: PROCEDURE: Procedure: endoscopic biopsy|PROCEDURE: Blood sampling|PROCEDURE: stool sampling
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: A Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Participants With T-cell Prolymphocytic Leukemia
Status: COMPLETED
Conditions: Leukemia|T-cell Prolymphocytic Leukemia (T-PLL)|Cancer
Interventions: DRUG: Venetoclax|DRUG: Ibrutinib
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study to Evaluate Safety & Usability of a New Formulation for Male Androgenetic Alopecia
Status: RECRUITING
Conditions: Androgenic Alopecia
Interventions: DRUG: FOL100|DRUG: Propecia 1Mg Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Preoperative Gabapentin Versus Bisoprolol for Hemodynamic Optimization During Sinus Surgery
Status: COMPLETED
Conditions: Blood Pressure
Interventions: DRUG: Gabapentin1200 mg|DRUG: bisoprolol 2.5mg|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Nitrous Oxide in OCD: Pilot Study
Status: RECRUITING
Conditions: Obsessive-Compulsive Disorder
Interventions: DRUG: Nitrous Oxide|DRUG: Nitrogen
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Laparoscopic Versus Robotic Assisted Laparoscopic Sacrocolpopexy for Vaginal Prolapse
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: PROCEDURE: robotic laparoscopic sacrocolpopexy|PROCEDURE: Laparoscopic Sacral Colpopexy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
Status: TERMINATED
Conditions: Polycystic Ovary Syndrome|Hyperandrogenism
Interventions: DRUG: Flutamide|DRUG: Progesterone|DRUG: estrace
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C With and Without Kidney Disease
Status: COMPLETED
Conditions: Chronic Hepatitis C
Interventions: DRUG: Peginterferon alfa-2a with Ribavirin|DRUG: Peginterferon alfa-2a
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Outcomes in Ovarian Cancer and Fallopian Tube Cancer Patients Using Complementary Alternative Medicine
Status: COMPLETED
Conditions: Ovarian Cancer|Peritoneal Primary Cancer|Fallopian Tube Cancer
Interventions: OTHER: healing touch|OTHER: massage therapy|OTHER: hypnosis|DRUG: Standard chemotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: The Use of Brazilian Green Propolis Extract (EPP-AF) in Patients Affected by COVID-19.
Status: COMPLETED
Conditions: Covid19
Interventions: DRUG: Brazilian Green Propolis Extract (EPP-AF)|OTHER: Standard care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Erector Spine Plane (ESP) Block for Analgesia in Pediatric Scoliosis Surgery
Status: RECRUITING
Conditions: Scoliosis|Regional Anesthesia|Pediatric Anesthesia|Orthopedic Disorder of Spine
Interventions: DRUG: Ropivacaine 0.2% Injectable Solution|DRUG: Normal saline 0.9% Injectable Solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study to Determine the Maximum Tolerated Dose for the Combination of Pomalidomide, Bortezomib and Low-Dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Status: COMPLETED
Conditions: Multiple Myeloma
Interventions: DRUG: Pomalidomide|DRUG: Bortezomib|DRUG: Dexamethasone
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MIRs03: Paravertebral Block With Ropivacaine Before Breast Cancer Surgery
Status: COMPLETED
Conditions: Malignant Neoplasm of Breast
Interventions: DRUG: Saline|DRUG: Ropivacaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Single Ascending Dose of FXI-GalNAc-siRNA in Healthy Subjects
Status: RECRUITING
Conditions: FXI
Interventions: DRUG: FXI-GalNAc-siRNA|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PK Comparison of GL2701 With Finasteride and Tamsulosin in Combination
Status: COMPLETED
Conditions: Benign Prostatic Hyperplasia (BPH)
Interventions: DRUG: In combination of 0.2mg finasteride and 5mg tamsulosin|DRUG: GL2701 capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose:
Clinical trial: Safety and Tolerability of Sub-retinal Transplantation of hESC Derived RPE (MA09-hRPE) Cells in Patients With Advanced Dry Age Related Macular Degeneration
Status: COMPLETED
Conditions: Dry Age Related Macular Degeneration
Interventions: BIOLOGICAL: MA09-hRPE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Anti-TGF Monoclonal Antibody (GC1008) in Relapsed Malignant Pleural Mesothelioma
Status: COMPLETED
Conditions: Pleural Malignant Mesothelioma
Interventions: DRUG: GC1008
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
Status: RECRUITING
Conditions: Multiple Myeloma
Interventions: DRUG: Bortezomib|DRUG: Dexamethasone|DRUG: Lenalidomide|DRUG: Cilta-cel|DRUG: Cyclophosphamide|DRUG: Fludarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: 16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis
Status: COMPLETED
Conditions: Anemia|End Stage Renal Disease
Interventions: DRUG: AKB-6548|DRUG: AKB-6548|DRUG: AKB-6548
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Heart and Renal Protection
Status: COMPLETED
Conditions: Kidney Disease, Chronic
Interventions: DRUG: Simvastatin 20 mg|DRUG: Ezetimibe 10mg|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED
Status: RECRUITING
Conditions: Persistent Corneal Epithelial Defect
Interventions: DRUG: lufepirsen|DRUG: Vehicle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Improving Dexterous Skills in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson Disease
Interventions: BEHAVIORAL: Dexterity training program (HOMEDEXT)|BEHAVIORAL: Theraband training program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19
Status: COMPLETED
Conditions: Acute Respiratory Tract Infection|Acute Respiratory Insufficiency|Pneumonia|Septic Shock|Hypoxemia
Interventions: PROCEDURE: Standard therapy recommended by the Ministry of Health of the Russian Federation.|PROCEDURE: Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin intramuscular injection|PROCEDURE: Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin inhalation|PROCEDURE: Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin intramuscular injection combined with Leitragin inhalation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: FACTORIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Equivalence of a Generic Ciclopirox Olamine Topical Suspension Compared to the Reference Ciclopirox Topical Suspension 0.77% for the Treatment of Tinea Pedis
Status: COMPLETED
Conditions: Tinea Pedis
Interventions: DRUG: Ciclopirox Olamine Topical Suspension|DRUG: Ciclopirox Topical Suspension 0.77%-Reference Product|DRUG: Ciclopirox Olamine Topical Suspension-Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Tourniquet in Total Knee Replacement Short and Long Duration: A Comparative Study
Status: ACTIVE_NOT_RECRUITING
Conditions: Tourniquet Palsy
Interventions: PROCEDURE: Applying a tourniquet for either a short or long time during total knee replacement
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Sintilimab Combined With Bevacizumab and Chemotherapy for Resectable Non-Small Cell Lung Cancer
Status: RECRUITING
Conditions: Lung Neoplasm Malignant
Interventions: DRUG: sintilimab|DRUG: bevacizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety, Tolerability, Pharmacokinetics and Efficacy of WOL071-007 in Atopic Dermatitis Patients
Status: COMPLETED
Conditions: Dermatitis, Atopic
Interventions: DRUG: 0.1% WOL071-007|DRUG: 0.3% WOL071-007|DRUG: 1.0% WOL071-007|DRUG: Placebo of WOL071-007
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection
Status: COMPLETED
Conditions: Skin and Subcutaneous Tissue Bacterial Infections|Gram-Positive Bacterial Infections
Interventions: DRUG: TNP-2092|DRUG: Vancomycin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of Short-term Postoperative Anticoagulant Therapy to Prevente Thrombosis in Arterovenous Fistula
Status: COMPLETED
Conditions: Thrombosis
Interventions: DRUG: Low molecular weight heparin|OTHER: non anticoagulant therapy group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Study About the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure
Status: COMPLETED
Conditions: Helicobacter Pylori Infection
Interventions: DRUG: Amoxicillin,Furazolidone|DRUG: Amoxicillin,Levofloxacin|DRUG: Tetracycline,Furazolidone
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Involvement in a Group-based Creative Expression Program on Psychotropic Drug Use in Persons With Dementia
Status: COMPLETED
Conditions: Dementia
Interventions: BEHAVIORAL: TimeSlips|BEHAVIORAL: Standard care activity program
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Dolastatin 10 in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia
Status: COMPLETED
Conditions: Leukemia|Myelodysplastic Syndromes
Interventions: DRUG: Dolastatin 10
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intranasal Dexmedetomidine Sedation and Analgesia During Pediatric Emergency Room Procedures
Status: RECRUITING
Conditions: Pain|Anesthesia
Interventions: DRUG: Intranasal Drug|DRUG: Intranasal Drug
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Positive Pressure Ventilation for ALI/ARDS:a Multicentre Randomized Controlled Trial
Status: UNKNOWN
Conditions: Acute Lung Injury|Acute Respiratory Distress Syndrome
Interventions: DEVICE: noninvasive positive pressure ventilation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE|Primary Purpose: TREATMENT
Clinical trial: Compare the Efficacy and Safety of 1PC111 With Pitavastatin and Ezetimibe in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia
Status: COMPLETED
Conditions: Primary Hypercholesterolemia|Mixed Dyslipidemias
Interventions: DRUG: Pitavastatin|DRUG: Ezetimibe|DRUG: 1PC111
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Stereotactic Radiotherapy for Oligo-Progressive Metastatic Cancer (The STOP Trial)
Status: ACTIVE_NOT_RECRUITING
Conditions: Metastatic Cancer
Interventions: RADIATION: Stereotactic Ablative Radiotherapy (SABR)|OTHER: Standard of Care Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of MeRT Treatment in Post-Traumatic Stress Disorder
Status: RECRUITING
Conditions: PostTraumatic Stress Disorder|Traumatic Brain Injury|Postconcussive Symptoms
Interventions: DEVICE: Active MeRT Treatment|DEVICE: Sham MeRT Treatment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Clinical Investigation to Evaluate Safety and Performance of the EndoFast Reliant™ System in Vaginal Wall Reinforcement
Status: COMPLETED
Conditions: Pelvic Organ Prolapse
Interventions: DEVICE: EndoFast Reliant™ system for Pelvic Organ Prolapse repair
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Relative Bioavailability and Food-Effect Study of GSK3640254 Tablet and Capsule Formulations in Healthy Participants
Status: TERMINATED
Conditions: HIV Infections
Interventions: DRUG: GSK3640254 Tablet|DRUG: GSK3640254 Capsule
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Dutch Intracerebral Hemorrhage Surgery Trial
Status: RECRUITING
Conditions: Intracerebral Hemorrhage|Minimally Invasive Surgical Procedures|Endoscopic Surgical Procedures
Interventions: DEVICE: Minimally invasive endoscopy-guided surgery
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Functional Rehabilitation of Upper Limb Apraxia in Patients Poststroke
Status: COMPLETED
Conditions: Stroke|Apraxias
Interventions: OTHER: Functional Rehabilitation of apraxia|OTHER: Traditional health educative protocol
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Phase I/II Study of Intratumoral Injection of CPG 7909, a TLR9 Agonist, Combined With Local Radiation for Patients With Recurrent Mycosis Fungoides.
Status: WITHDRAWN
Conditions: Mycosis Fungoides
Interventions: DRUG: CPG 7909
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Study To See Why Patients Agree To or Decline To Have Treatment After Surgery
Status: COMPLETED
Conditions: Cutaneous Melanoma
Interventions: BEHAVIORAL: Demographics Questionnaire|BEHAVIORAL: Adjuvant Treatment Beliefs Scale10|BEHAVIORAL: Functional Assessment of Cancer Therapy - Melanoma (FACT-M)11|BEHAVIORAL: Functional Assessment of Chronic Illness Therapy - Treatment Satisfaction - General (FACIT-TS-G)13|BEHAVIORAL: Decisional Regret14|BEHAVIORAL: Clinician Preference for Treatment
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Cardio-metabolic and Mental Health in Women With Gestational Diabetes Mellitus and Their Offspring
Status: COMPLETED
Conditions: Gestational Diabetes Mellitus
Interventions: BEHAVIORAL: interdisciplinary lifestyle and psychosocial intervention
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Periodized Aerobic Interval Training in Metabolic Syndrome
Status: COMPLETED
Conditions: Metabolic Syndrome|Metabolic Syndrome X
Interventions: BEHAVIORAL: Periodized aerobic interval training
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults
Status: COMPLETED
Conditions: Glucose Intolerance
Interventions: OTHER: High Intensity Interval Training #1|OTHER: Moderate intensity continuous training|OTHER: High Intensity Interval Training #2|OTHER: High Intensity Interval Training #3
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: The Effects of Prucalopride in Patients With Constipation Predominant Irritable Bowel Syndrome
Status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Interventions: DRUG: Prucalopride 2mg
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Preoperative Alpha Blockade for Pheochromocytoma
Status: COMPLETED
Conditions: Pheochromocytoma|Paraganglioma
Interventions: DRUG: Phenoxybenzamine|DRUG: Doxazosin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy of Near Infrared Phototherapy in Type 2 Diabetic Neuropathy
Status: TERMINATED
Conditions: Neuropathy
Interventions: OTHER: Infrared Phototherapy|OTHER: Sham
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effects of Multicomponent Exercise on Subchondral Bone and Cartilage in Postmenopausal Women With Knee Osteoarthritis
Status: RECRUITING
Conditions: Osteoarthritis, Knee
Interventions: BEHAVIORAL: Multicomponent exercise regimen|BEHAVIORAL: Standard rehabilitative management
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Lower Limb Function After Spinal Cord Injury
Status: COMPLETED
Conditions: Spinal Cord Injury
Interventions: DRUG: D-Cycloserine|DRUG: Placebo|OTHER: Training|OTHER: Stimulation|OTHER: Placebo Stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Preliminary Anti-tumour Activity of mTor Kinase Inhibitor in Advanced Tumours
Status: WITHDRAWN
Conditions: Cancer|Advanced Solid Tumours|Lymphomas
Interventions: DRUG: AZD8055
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A New Rehabilitation Tool in Fibromyalgia
Status: COMPLETED
Conditions: Fibromyalgia|Pain
Interventions: OTHER: Physical exercises treatment|OTHER: Perceptive Rehabilitation Treatment|OTHER: Control group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Application of 68Ga-DOTA-TATE and 68Ga-DOTA-JR11 PET/CT in the Diagnosis and Evaluation of TIO
Status: UNKNOWN
Conditions: Tumor-Induced Osteomalacia
Interventions: DRUG: 68Ga-Dotatate|DRUG: 68Ga-DOTA-JR11
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Safety, Tolerability,PK/PD, Food Effect of Single and Multiple Ascending Doses of HSK31858 in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers
Interventions: DRUG: HSK31858, tablet|DRUG: Placebo, tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: OTHER
Clinical trial: A Study to Evaluate the Safety and Efficacy of ly011 Cell Injection in the Treatment of Advanced Gastric Adenocarcinoma
Status: RECRUITING
Conditions: Advanced Gastric Adenocarcinoma
Interventions: BIOLOGICAL: LY011
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Incorporation of Photobiomodulation Therapy in an Exercise Program With Blood Flow Restriction for Knee Osteoarthritis
Status: UNKNOWN
Conditions: Osteoarthritis, Knee|Physical Therapy Modalities
Interventions: DEVICE: blood flow restriction|DEVICE: Photobiomodulation|DEVICE: Placebo photobiomodulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Activity of Chronic Inflammation in PCOS
Status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Interventions: DIAGNOSTIC_TEST: Measurement and comparison of leucocytosis and concentrations of C-reactive protein (CRP), interleukin-1 (IL-1), IL-6, IL-10, Tumor Necrosis Factor (TNF-alpha) in PCOS phenotypes A, B, C and D|DIAGNOSTIC_TEST: Evaluation of the correlation of serum concentrations of selected inflammatory markers (leucocytosis, CRP, IL-1, IL-6, IL-10, TNF-alpha) with metabolic and hormonal parameters
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Canakinumab in Patients With COVID-19 and Type 2 Diabetes
Status: COMPLETED
Conditions: Coronavirus Infection|Diabetes Mellitus, Type 2
Interventions: DRUG: Canakinumab|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: PD-1 Blockade and Bevacizumab Replace Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma
Status: NOT_YET_RECRUITING
Conditions: Nasopharyngeal Carcinoma
Interventions: DRUG: Bevacizumab+Toripalimab+gemcitabine, adjuvant with Bevacizumab and Toripalimab|DRUG: Bevacizumab+Toripalimab+gemcitabine, adjuvant with Toripalimab
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Skin Irritation Test of LEO 80185 Gel in Healthy Japanese Subjects
Status: COMPLETED
Conditions: Skin and Connective Tissue Diseases
Interventions: DRUG: LEO 80185 gel, vehicle, liquid paraffin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Removal of Urinary Catheter After Radical Surgery
Status: COMPLETED
Conditions: Cervical Cancer|Radical Hysterectomy|Bladder Dysfunction
Interventions: PROCEDURE: REMOVAL OF URINARY CATHETER AFTER RADICAL SURGERY
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: OTHER
Clinical trial: Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers
Status: COMPLETED
Conditions: Colorectal Neoplasm|Hereditary Nonpolyposis
Interventions: DRUG: Celecoxib (SC-58635)
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Treatment of Depression With Connectivity Guided Robotically Delivered rTMS
Status: TERMINATED
Conditions: Major Depressive Disorder
Interventions: DEVICE: repetitive transcranial magnetic stimulation|DEVICE: robotic arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Rituximab for Lymphoma Patients
Status: COMPLETED
Conditions: Lymphoma
Interventions: DRUG: Fludarabine|DRUG: Novantrone|DRUG: Decadron|DRUG: Rituximab|DRUG: Interferon|DRUG: Doxorubicin|DRUG: Vincristine|DRUG: Bleomycin|DRUG: Cyclophosphamide|DRUG: Etoposide|DRUG: Cisplatin|DRUG: Ara-C|DRUG: Methyl-Prednisolone|DRUG: Procarbazine|DRUG: Prednisone
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effect of Tramadol on Postoperative Sore Throat After General Anesthesia
Status: RECRUITING
Conditions: Post-operative Sore Throat|Intubation Intratracheal|Thyroid Surgery
Interventions: DRUG: Tramadol hydrochloride|OTHER: Normal Saline
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Amikacin Pharmacokinetics to Optimize Dosing Recommendations in Neonates With Perinatal Asphyxia Treated With Hypothermia
Status: UNKNOWN
Conditions: Asphyxia Neonatorum
Interventions: DRUG: Amikacin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Extension Study to Evaluate the Safety and Tolerability of NBI-921352 When Used With Anti-seizure Medications in Adults With Focal Onset Seizures
Status: TERMINATED
Conditions: Focal Onset Seizure|Focal Onset Epilepsy
Interventions: DRUG: NBI-921352
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Home Remineralization of White Spot Lesions With Two Different Toothpastes.
Status: COMPLETED
Conditions: White Spot Lesion
Interventions: OTHER: Biorepair toothpaste|OTHER: Colgate toothpaste
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass Surgery
Status: COMPLETED
Conditions: Vasoplegic Syndrome|Vasoplegia|Surgery-Complications|Surgery|Cardiovascular Diseases|Cardiovascular Morbidity
Interventions: OTHER: vasoplegic syndrome
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p