pankajmathur/National_Library_of_Medicine_Studies_data huggingface dataset:
Clinical trial: Safety and Immunogenicity Study of GSK's Clostridium Difficile Vaccine 2904545A When Administered in Healthy Adults Aged 18-45 Years and 50-70 Years
Status: COMPLETED
Conditions: Clostridium Infections
Interventions: BIOLOGICAL: C. difficile investigational vaccine based on the F2 antigen (GSK2904545A)|BIOLOGICAL: C. difficile investigational vaccine based on the F2 antigen (GSK2904545A) adjuvanted with AS01B|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SEQUENTIAL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Efficacy and Safety of Obturator Nerve Block During Transurethral Resection on Non-muscle Invasive Intermediate and High Risk Lateral Wall Bladder Tumours
Status: COMPLETED
Conditions: Bladder Cancer Stage 0|Bladder Cancer Stage I
Interventions: PROCEDURE: Nerve Stimulator-guided Obturator Nerve Block
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Impact of Motivational Interviews Within Pharmacy Care Upon Adherence to Cardiovascular Medicines
Status: COMPLETED
Conditions: Coronary Heart Disease
Interventions: BEHAVIORAL: Pharmacist counselling session with a motivational interview
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Novel Myofunctional Water Bottle to Reduce OSA and Snoring Study
Status: RECRUITING
Conditions: Obstructive Sleep Apnea|Snoring
Interventions: DEVICE: Myofunctional therapy (MT) nozzle|OTHER: Placebo nozzle
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Yoga and Aerobic Dance for Pain Management in Juvenile Idiopathic Arthritis
Status: UNKNOWN
Conditions: Juvenile Idiopathic Arthritis|Pain
Interventions: BEHAVIORAL: Online yoga training (Group A)|BEHAVIORAL: Online aerobic dance training (Group B)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of a Telerehabilitation Approach in Children With Cystic Fibrosis
Status: UNKNOWN
Conditions: Cystic Fibrosis
Interventions: OTHER: Telerehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: A Pilot Study Comparing Performance of Blind Participants on 12 Tasks, With and Without the ARIA Device
Status: RECRUITING
Conditions: Blindness and Low Vision
Interventions: DEVICE: ARIA Glasses ( Augmented Reality in Audio )
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: HEMOTOL: Efficacy and Safety of Hemodialysis On-line Monitoring Devices on Hemodynamic Stability in Intensive Care Unit
Status: COMPLETED
Conditions: Hemodialysis
Interventions: DEVICE: Standard Hemodialysis|DEVICE: with Blood Volume Management (BVM®) only|DEVICE: with Blood Volume (BVM®) and Temperature (BTM®) on-line monitoring
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Evaluation of AGN-150998 in Exudative Age-related Macular Degeneration (AMD)
Status: COMPLETED
Conditions: Age-related Macular Degeneration
Interventions: DRUG: AGN-150998|DRUG: ranibizumab|OTHER: Sham Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: BIOD-531 vs. Humalog Mix 75/25 vs. Humulin R U-500 Post-Meal Glucose Control in Patients With Severe Insulin Resistance
Status: COMPLETED
Conditions: Diabetes Mellitus
Interventions: DRUG: BIOD-531|DRUG: Humalog Mix 75/25|DRUG: Humulin R U-500|DRUG: BIOD-531
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Evaluation of Telemedicine Practices for Contraceptive Counseling During the COVID-19 Pandemic: A Randomized Controlled Trial
Status: COMPLETED
Conditions: Family Planning Services|Telemedicine|Pregnant Women|Women's Health|COVID-19 Pandemic
Interventions: BEHAVIORAL: Video call sessions
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach.
Status: COMPLETED
Conditions: Postoperative Pain|Pain, Acute
Interventions: DRUG: Dexketoprofen/tramadol (27mg/75mg)|DRUG: Tramadol hydrochloride|DRUG: Paracetamol|DRUG: Ropivacaine Hydrochloride 7.5 MG/ML|DRUG: Levobupivacaine Hydrochloride
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Development and Feasibility Testing of a Group-based PFMT Programme for Antenatal Women in Nanjing City in China
Status: COMPLETED
Conditions: Urinary Incontinence
Interventions: BEHAVIORAL: Group-based PFMT group
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Effect of Rimonabant on Weight Gain and Body Composition in Adults With Prader Willi Syndrome
Status: TERMINATED
Conditions: Prader-willi Syndrome
Interventions: DRUG: rimonabant|DRUG: placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Assessment of the Efficacy and Safety of EESS in Patients With Incomplete Spinal Cord Injuries
Status: UNKNOWN
Conditions: Spinal Cord Injuries
Interventions: DEVICE: Stimulation and automated rehabilitation / automated rehabilitation|DEVICE: Automated rehabilitation / Stimulation and automated rehabilitation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Encapsulated Nutrients' Acute Effects on Appetite; ENcapsulated, lipiD, aminO, pRobiotic, SatiEty
Status: COMPLETED
Conditions: Appetite; Lack or Loss, Nonorganic Origin
Interventions: DIETARY_SUPPLEMENT: Encapsulated nutrients|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Panobinostat and Everolimus in Treating Patients With Metastatic or Unresectable Renal Cell Cancer That Does Not Respond to Treatment With Sunitinib Malate or Sorafenib Tosylate
Status: TERMINATED
Conditions: Clear Cell Renal Cell Carcinoma|Recurrent Renal Cell Cancer|Stage III Renal Cell Cancer|Stage IV Renal Cell Cancer
Interventions: DRUG: panobinostat|DRUG: everolimus|OTHER: laboratory biomarker analysis|OTHER: pharmacological study|OTHER: liquid chromatography|OTHER: mass spectrometry|OTHER: enzyme-linked immunosorbent assay|OTHER: immunohistochemistry staining method
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Deep Transcranial Magnetic Stimulation (dTMS) of the Medial Prefrontal Cortex in Food Addiction and Obesity
Status: UNKNOWN
Conditions: Food Addiction|Obesity, Morbid
Interventions: DEVICE: dTMS with mPFC stimulation
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Iliac Angioplasties: Impact of the Fusion of Images on the Irradiation Rate
Status: UNKNOWN
Conditions: Irradiation Rate|Image, Body|Iliac Artery Disease
Interventions: PROCEDURE: Standard Angioplasty|PROCEDURE: Angioplasty with D images
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Overcoming High On-Treatment Platelet Reactivity (HPR) During Prasugrel Therapy With Ticagrelor
Status: UNKNOWN
Conditions: Coronary Artery Disease
Interventions: DRUG: Prasugrel|DRUG: Ticagrelor
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Mifepristone for the Prevention of Relapses of Alcohol Drinking
Status: COMPLETED
Conditions: Alcohol Use Disorders (AUD)
Interventions: DRUG: Mifepristone 600-mg/day or placebo for a week
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Maintenance With OSE2101 Plus FOLFIRI, or FOLFIRI After FOLFIRINOX-based Induction Therapy in Locally Advanced or Metastatic Pancreatic Ductal Adenocarcinoma
Status: RECRUITING
Conditions: Pancreatic Ductal Adenocarcinoma|Locally Advanced Cancer|Metastatic Cancer
Interventions: DRUG: FOLFIRI|DRUG: OSE2101
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Repeat Intranodal Injections of Ad-ISF35
Status: TERMINATED
Conditions: Non-Hodgkin's Lymphoma|Follicular Lymphoma|Diffuse Large Cell Lymphoma|Mantle Cell Lymphoma|Small Lymphocytic Lymphoma|Chronic Lymphocytic Leukemia
Interventions: BIOLOGICAL: ISF35
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Use of Fibrin Sealant Patch for Vein Anastomosis During Deceased Donor Liver Transplantation- Randomized Clinical Trial
Status: RECRUITING
Conditions: Liver Transplant; Complications
Interventions: DRUG: TachoSil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION
Clinical trial: Biobehavioral Reward Responses Associated With Consumption of Nutritionally Diverse Ultra-Processed Foods
Status: RECRUITING
Conditions: Obesity|Overeating|Food Addiction
Interventions: OTHER: Intake of nutritionally diverse ultra-processed foods
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Self-Reported Pain in Children Submitted to Single Infiltration of Articaine During Primary Molar Extraction
Status: ACTIVE_NOT_RECRUITING
Conditions: Dental Pain|Anesthesia, Local
Interventions: DRUG: Lidocaine|DRUG: Articaine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease
Status: COMPLETED
Conditions: Crohn's Disease
Interventions: DRUG: PF-00547659 SC injection|DRUG: PF-00547659 SC injection|DRUG: PF-00547659 SC injection|DRUG: PF-00547659 SC injection
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Optimal Handling of Common Bile Duct Calculus, a Prospective Study
Status: TERMINATED
Conditions: Cholelithiasis
Interventions: OTHER: no measures taken to clear bile ductus|PROCEDURE: clearance of bile ductus
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Premedication With Melatonin in Lumbar Medial Branch Block Procedure
Status: COMPLETED
Conditions: Anxiety
Interventions: DRUG: 2 mg Melatonin|DRUG: 10mg Melatonin|OTHER: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Metformin Postpartum for GDM RCT for Reduced Weight Retention
Status: COMPLETED
Conditions: Diabetes, Gestational
Interventions: DRUG: Metformin|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia|Myelodysplastic Syndrome With Excess Blasts-2
Interventions: DRUG: Gilteritinib|DRUG: Midostaurin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Polyphenols Found in Pomegranate Juice on Postprandial Blood Glucose in Vivo
Status: COMPLETED
Conditions: Hyperglycaemia
Interventions: OTHER: Control without pomegranate juice|OTHER: Test with pomegranate juice
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: [18F]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer
Status: COMPLETED
Conditions: Ovarian Neoplasm
Interventions: DRUG: Pazopanib and paclitaxel
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Apalutamide Plus Intermittent Hormone Therapy Versus Intermittent Hormone Therapy Alone in Prostate Cancer
Status: WITHDRAWN
Conditions: Prostate Cancer
Interventions: DRUG: Apalutamide|DRUG: IHT
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer
Status: COMPLETED
Conditions: Carcinoma of the Appendix|Colorectal Cancer|Primary Peritoneal Cavity Cancer
Interventions: DRUG: oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Characterization of Biophysical Stromal Properties in Human Cancer: Towards Personalized Computational Oncology
Status: RECRUITING
Conditions: Carcinomatosis, Peritoneal|Pancreas Cancer|Ovarian Cancer|Colon Cancer
Interventions: PROCEDURE: MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Study of the Safety and Immunogenicity of Long-term GNR-069 Therapy in ITP Patients
Status: COMPLETED
Conditions: Idiopathic Thrombocytopenic Purpura
Interventions: BIOLOGICAL: GNR-069
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety Study for Subjects With Mild-to-Moderate Alzheimer's Disease
Status: COMPLETED
Conditions: Alzheimer's Disease
Interventions: DRUG: Placebo|DRUG: ABT-126|DRUG: donepezil
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis
Status: COMPLETED
Conditions: Spondylolisthesis|Spinal Stenosis|Low Back Pain
Interventions: PROCEDURE: Decompressive laminectomy|OTHER: Non-surgical treatments|PROCEDURE: Fusion--Instrumented|PROCEDURE: Fusion-Non-instrumented
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Avoiding Bacterial Contamination of Clean Catch Urine Cultures in Ambulatory Patients in the Emergency Department
Status: COMPLETED
Conditions: Urinary Tract Infections|Bacteriuria|Urinalysis
Interventions: OTHER: Container|OTHER: Silver Impregnated Wipe|OTHER: Funnel|OTHER: Castile-soap wipe
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Improving Supportive Care For Patients With Thoracic Malignancies
Status: COMPLETED
Conditions: Lung Cancer|Quality of Life|Supportive Care
Interventions: BEHAVIORAL: Weekly telephone symptom assessment
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Bioequivalence Study of Doxazosin 4 Mg Orally-Disintegrating Tablet With Or Without Water To Doxazosin 4 Mg Japanese Marketed Immediate Release Tablet Under Fasted Condition
Status: COMPLETED
Conditions: Hypertension
Interventions: DRUG: Doxazosin 4 mg Japanese marketed IR tablet|DRUG: Doxazosin 4 mg ODT with water|DRUG: Doxazosin 4 mg ODT without water
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Diacutaneous Fibrolysis on Lateral Epicondylitis
Status: UNKNOWN
Conditions: Tennis Elbow
Interventions: OTHER: Actual Diacutaneous Fibrolysis|OTHER: Sham Diacutaneous Fibrolysis|OTHER: Protocolized Physiotherapy
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Study of CM512 in Healthy Subjects and Patients With Atopic Dermatitis
Status: NOT_YET_RECRUITING
Conditions: Atopic Dermatitis
Interventions: BIOLOGICAL: CM512|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Pilot Study for the Treatment of Patients With Metastatic and High Risk Sarcomas and Primitive Neuroectodermal Tumors
Status: COMPLETED
Conditions: Neuroectodermal Tumor, Primitive|Neuroepithelioma|Osteosarcoma|Sarcoma|Sarcoma, Ewing's
Interventions: DRUG: vincristine, adriamycin and cytoxan, alternating with ifosfamide VP-16
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Oxaliplatin and Capecitabine in the Treatment of Relapsed/Refractory Carcinoma of Unknown Primary Site
Status: COMPLETED
Conditions: Neoplasms, Unknown Primary
Interventions: DRUG: Oxaliplatin|DRUG: Capecitabine
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: The Safety and Efficacy of Epidural Oxycodone
Status: ACTIVE_NOT_RECRUITING
Conditions: Pain, Postoperative
Interventions: DRUG: Oxycodone intravenously|DRUG: Oxycodone epidurally
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia
Status: ACTIVE_NOT_RECRUITING
Conditions: Acute Myeloid Leukemia
Interventions: DRUG: Gilteritinib|DRUG: Midostaurin|DRUG: Daunorubicin|DRUG: Cytarabine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Physiopathological Study of Autonomic Failure in Parkinson's Disease
Status: COMPLETED
Conditions: Parkinson's Disease
Interventions: OTHER: Biopsies of peripheral autonomic nervous system|OTHER: Autonomic dysfunction questionnaires|OTHER: Electrophysiological tests
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: HEALTH_SERVICES_RESEARCH
Clinical trial: Zinc Therapy in Critical Illness
Status: ACTIVE_NOT_RECRUITING
Conditions: Severe Sepsis
Interventions: DIETARY_SUPPLEMENT: Zinc sulfate
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effects of Standing and Light-intensity Activity on Ambulatory Blood Pressure and Blood Glucose
Status: COMPLETED
Conditions: Diabetes|Hypertension|Sleep
Interventions: OTHER: Maintaining posture and energy expenditure|OTHER: Increasing energy expenditure|OTHER: Changing posture|OTHER: Increasing energy expenditure and changing posture
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Buprenorphine as Adjunct to Outpatient Induction Onto Vivitrol
Status: TERMINATED
Conditions: Opioid-use Disorder
Interventions: DRUG: Buprenorphine|DRUG: Naltrexone|DRUG: Vivitrol
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Donafenib Combined With Hepatic Artery Chemoembolization for Perioperative Treatment of Liver Transplantation
Status: RECRUITING
Conditions: Hepatocellular Carcinoma
Interventions: DRUG: Donafenib|PROCEDURE: TACE
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury
Status: COMPLETED
Conditions: Pediatric Traumatic Brain Injury
Interventions: DRUG: Probenecid and N-acetyl cysteine|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: T- XELOX in HER2-positive Stage III Gastric Cancer After D2 Gastrectomy
Status: UNKNOWN
Conditions: Gastric Cancer
Interventions: DRUG: Trastuzumab|DRUG: Capecitabine|DRUG: Oxaliplatin
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Blinatumomab Plus HLA-Mismatched Cellular Therapy for Relapsed/Refractory CD19+ ALL
Status: ACTIVE_NOT_RECRUITING
Conditions: B-Cell Acute Lymphoblastic Leukaemia|ALL, Adult|B-ALL
Interventions: DRUG: Blinatumomab|OTHER: Haplo-Mismatched Cell Therapy (HMCT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Regorafenib in Combination With Venetoclax and Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia
Status: NOT_YET_RECRUITING
Conditions: Myelodysplastic Syndrome/Acute Myeloid Leukemia|Recurrent Acute Myeloid Leukemia|Recurrent Myelodysplastic Syndrome|Refractory Acute Myeloid Leukemia|Refractory Myelodysplastic Syndrome
Interventions: DRUG: Azacitidine|PROCEDURE: Biospecimen Collection|PROCEDURE: Bone Marrow Aspiration|DRUG: Regorafenib|DRUG: Venetoclax
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Triamcinolone Acetonide Plus Laser Therapy to Treat Age-Related Macular Degeneration
Status: COMPLETED
Conditions: Macular Degeneration
Interventions: DRUG: TAC-PF|DRUG: Triamcinolone Acetonide
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Simplified Pulmonary Vein Isolation Using singLe Catheter and IntraCardiac Echocardiography
Status: RECRUITING
Conditions: Atrial Fibrillation
Interventions: PROCEDURE: ICE visualization and map construction
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE
Status: COMPLETED
Conditions: Diphtheria|Tetanus|Poliomyelitis
Interventions: BIOLOGICAL: Diphtheria, tetanus, polio and pertussis vaccination
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Phase II Trial of BIBW 2992 (Afatinib) in Genetically Pre-screened Cancers With EGFR and/or HER2 Gene Amplification.
Status: TERMINATED
Conditions: Neoplasms
Interventions: DRUG: BIBW 2992 (Afatinib)
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Study of Tibial Shaft Fracture Fixation: Intramedullary Nailing Comparing With Dynamic Compression Plate
Status: COMPLETED
Conditions: Tibial Shaft Fracture
Interventions: PROCEDURE: Dynamic Compression Plate|PROCEDURE: Unreamed intramedullary nailing
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorders
Status: COMPLETED
Conditions: AML|ALL|CML Chronic Phase, Accelerated Phase, or Blast Crisis|CLL|MDS|RELAPSED NON-HODGKIN'S OR HODGKIN'S LYMPHOMA|APLASTIC ANEMIA|MULTIPLE MYELOMA|MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET)
Interventions: DRUG: Cyclophosphamide|DRUG: fludarabine|DRUG: cyclosporine|DRUG: methotrexate|BIOLOGICAL: G-CSF
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Milk-derived Gangliosides for Inflammatory Bowel Disease
Status: WITHDRAWN
Conditions: Inflammatory Bowel Disease
Interventions: DIETARY_SUPPLEMENT: Ganglioside|DIETARY_SUPPLEMENT: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Risk for Ketonaemia in Type 1 Diabetes Pregnancies With Sensor-augmented Pump Therapy
Status: COMPLETED
Conditions: Pregnant Women With Type 1 Diabetes
Interventions: DEVICE: SAP with stop before low|DEVICE: SAP with stop on low
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
Status: RECRUITING
Conditions: Pain
Interventions: DRUG: OxyCODONE 5 mg Oral Tablet|DRUG: Oxytocin nasal spray|OTHER: Placebo Oxycodone|OTHER: Placebo oxytocin|DRUG: OxyCODONE 2.5 mg Oral Tablet
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: BASIC_SCIENCE
Clinical trial: The Efficacy of Decision Support E-book for Prostate Biopsy Decision Making
Status: COMPLETED
Conditions: Prostate-Specific Antigen
Interventions: BEHAVIORAL: Using an E-Book
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, CARE_PROVIDER)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy
Status: WITHDRAWN
Conditions: Coronary Heart Disease (CHD)
Interventions: OTHER: Treatment of CHD risk factors|DRUG: Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.|DRUG: Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.|PROCEDURE: PCA|PROCEDURE: CABG|DEVICE: Cardiospec|DRUG: Aspirin, Isosorbide mononitrate, Atenolol, Enalapril
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: An Open-Label, Multicenter, Expanded Access Study of Oral AMN 107 in Adult Patients With Imatinib (Glivec®/Gleevec®_ - Resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase
Status: COMPLETED
Conditions: Leukemia, Myeloid, Chronic
Interventions: DRUG: Glivec®/Gleevec®
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Efficacy and Safety of the Ophthalmic Solution PRO-087 Versus Systane ® Ultra and Ultra Preservative Free (087LATAMFIV)
Status: COMPLETED
Conditions: Dry Eye Syndrome
Interventions: DRUG: PRO-087|DRUG: Systane Ultra|DRUG: Systane Ultra Preservative Free
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Bifidobacterium Supplementation for Very Low Birth Weight Infants
Status: COMPLETED
Conditions: Preterm Infants
Interventions: DIETARY_SUPPLEMENT: Bifidobacterium bifidum supplementation|DIETARY_SUPPLEMENT: Placebo contains dextrin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI
Status: NOT_YET_RECRUITING
Conditions: Reperfusion Injury, Myocardial|Myocardial Infarction
Interventions: DRUG: L-Carnitine|DRUG: The standard care for the management of myocardial infarction post PCI
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R
Status: COMPLETED
Conditions: Extracorporeal CO2 Removal|Acute Respiratory Distress Syndrome|Chronic Obstructive Pulmonary Disease Exacerbation|Pulmonary Disease
Interventions: DEVICE: ECCO2R pulsatile configuration
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Sacituzumab Govitecan In TNBC
Status: RECRUITING
Conditions: Invasive Breast Cancer|Triple Negative Breast Cancer|ER-Negative Breast Cancer|PR-Negative Breast Cancer|HER2-negative Breast Cancer
Interventions: DRUG: Sacituzumab Govitecan|DRUG: Pembrolizumab
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Acute Effects of Heat, Cold and Stretching on Knee Proprioception and Vertical Jump
Status: COMPLETED
Conditions: Healthy
Interventions: OTHER: Stretching|OTHER: Hot pack application|OTHER: Cold pack application
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With Sepsis (Limiting AKI Progression In Sepsis)
Status: TERMINATED
Conditions: Sepsis|Acute Kidney Injury|Septic Shock
Interventions: DEVICE: Subject management guided by NephroCheck® test|OTHER: Standard of Care
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: DIAGNOSTIC
Clinical trial: Resistance and Aerobic Exercise With Nutritional Supplementation in Men and Women
Status: COMPLETED
Conditions: Obesity
Interventions: DIETARY_SUPPLEMENT: Whey protein supplementation with exercise|OTHER: Non protein supplementation with exercise (control)
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: PREVENTION
Clinical trial: A Study to Test Safety and Efficacy of Baricitinib in Participants With Diabetic Kidney Disease
Status: COMPLETED
Conditions: Diabetic Kidney Disease
Interventions: DRUG: Baricitinib|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy
Status: COMPLETED
Conditions: Pain
Interventions: DRUG: Hydrocodone/Acetaminophen Extended Release|DRUG: Acetaminophen|DRUG: Morphine Extended Release|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (PARTICIPANT)|Primary Purpose: TREATMENT
Clinical trial: Double-Blind Study of Timunox (Thymopentin) in Asymptomatic HIV-Infected Patients Receiving Either Mono (AZT or ddI) or Combination (AZT / ddI or AZT / ddC) Anti-Retroviral Therapy
Status: COMPLETED
Conditions: HIV Infections
Interventions: DRUG: Thymopentin|DRUG: Stavudine|DRUG: Zidovudine|DRUG: Zalcitabine|DRUG: Didanosine
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: DOUBLE|Primary Purpose: TREATMENT
Clinical trial: Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach
Status: RECRUITING
Conditions: Gastric Cancer|Atrophic Gastritis|Gastric Dysplasia|H.Pylori Infection
Interventions: DEVICE: Breath sampling for VOC detection|PROCEDURE: Surgery material collection for VOC headspace analysis|DIAGNOSTIC_TEST: Upper endoscopy|DIAGNOSTIC_TEST: Microbiota testing
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effect of Food on the Pharmacokinetics of Meloxicam in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: DRUG: Meloxicam, low dose|DRUG: Meloxicam, medium dose|DRUG: Meloxicam, high dose
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: MUC1 Vaccine for Triple-negative Breast Cancer
Status: COMPLETED
Conditions: Breast Cancer|Inflammatory Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer|Triple-negative Breast Cancer
Interventions: BIOLOGICAL: MUC-1 peptide vaccine|BIOLOGICAL: poly ICLC|BIOLOGICAL: MUC1 peptide-poly-ICLC adjuvant vaccine|OTHER: laboratory biomarker analysis|OTHER: enzyme-linked immunosorbent assay|OTHER: flow cytometry
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: OTHER
Clinical trial: Feasibility of Semi-Permanent Tattoo for Treatment Alignment in Radiation Therapy
Status: ACTIVE_NOT_RECRUITING
Conditions: Tattoo; Pigmentation|Cancer, Treatment-Related
Interventions: DEVICE: Semi-Permanent Tattoo Ink
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Treatment of Chronic Subdural Hematoma by Corticosteroids
Status: COMPLETED
Conditions: Chronic Subdural Hematomas
Interventions: DRUG: Methylprednisolone|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: A Phase 2 Study of BNC210 for the Acute Treatment of Social Anxiety Disorder
Status: COMPLETED
Conditions: Social Anxiety Disorder
Interventions: DRUG: 225 mg BNC210|DRUG: 675 mg BNC210|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Single Dose Manufacturing Site (Pfizer vs. BIP) And Device (Prefilled Syringe vs. Prefilled Pen) Comparability Study For Bococizumab In Healthy Volunteers
Status: COMPLETED
Conditions: Healthy
Interventions: BIOLOGICAL: bococizumab PFS:Pfizer|BIOLOGICAL: bococizumab PFS: BIP|BIOLOGICAL: bococizumab PFP
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
Status: RECRUITING
Conditions: ARDS|Lung Protective Ventilation
Interventions: DRUG: cisatracurium
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Noninvasive Assessment of Neuronal Damage by MRI Sodium ( 23Na ) in Amyotrophic Lateral Sclerosis
Status: UNKNOWN
Conditions: Amyotrophic Lateral Sclerosis
Interventions: OTHER: sodium MRI
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: DIAGNOSTIC
Clinical trial: Islet Transplantation in Type 1 Diabetics Using the Edmonton Protocol of Steroid Free Immunosuppression
Status: COMPLETED
Conditions: Diabetes Mellitus, Type 1
Interventions: DRUG: Transplantation of Human Islets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Human CD19 Targeted T Cells Injection Therapy for Relapsed and Refractory CD19-positive Leukemia
Status: UNKNOWN
Conditions: CD19-positive|Acute Lymphoblastic Leukemia
Interventions: DRUG: Human CD19 targeted T Cells Injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular Holes.
Status: RECRUITING
Conditions: Macular Holes
Interventions: PROCEDURE: Hydrated Amniotic Membrane Plug|PROCEDURE: ILM filling|PROCEDURE: Conventional ILM peeling
Study Type: INTERVENTIONAL
Study Design: Allocation: NON_RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Relationship Between Gastric Accommodation, TLESRs and Reflux in HV and in GERD With or Without Overlapping Dyspepsia
Status: COMPLETED
Conditions: Gastro-esophageal Reflux Disease|Functional Dyspepsia|Health
Interventions: PROCEDURE: device: combined solid state HRiM
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: BASIC_SCIENCE
Clinical trial: Phase 2 Study in Patients With MiT Tumors
Status: COMPLETED
Conditions: Renal Cell Carcinoma (RCC)|Alveolar Soft Part Sarcoma (ASPS)|Clear Cell Sarcoma (CCS)
Interventions: DRUG: ARQ 197
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis
Status: RECRUITING
Conditions: Metastatic Pancreatic Carcinoma|Stage IV Pancreatic Cancer AJCC v8|Metastatic Malignant Neoplasm in the Peritoneum
Interventions: DRUG: Cisplatin|DRUG: Hyperthermic Intraperitoneal Chemotherapy|DRUG: Nab-paclitaxel|PROCEDURE: Computed Tomography|PROCEDURE: Magnetic Resonance Imaging|PROCEDURE: Positron Emission Tomography
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach
Status: COMPLETED
Conditions: Attention Deficit Hyperactivity Disorder|ADHD
Interventions: OTHER: fMRI scans|DRUG: Atomoxetine arm|DRUG: Methylphenidate arm
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
Status: RECRUITING
Conditions: Rheumatoid Arthritis
Interventions: OTHER: Diet 1|OTHER: Diet 2
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: TRIPLE (PARTICIPANT, CARE_PROVIDER, OUTCOMES_ASSESSOR)|Primary Purpose: SUPPORTIVE_CARE
Clinical trial: Safety and Efficacy of SPD503 in Treating Attention-Deficit/Hyperactivity Disorder (ADHD) in Children Aged 6-17
Status: COMPLETED
Conditions: Attention Deficit Disorder With Hyperactivity
Interventions: DRUG: SPD503 (Guanfacine hydrochloride) (2 mg)|DRUG: SPD503 (3 mg)|DRUG: SPD503 (4 mg)|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Vaporized Nicotine and Autonomic Control
Status: COMPLETED
Conditions: Electronic Cigarette Use
Interventions: DEVICE: Electronic Cigarette containing nicotine|DEVICE: Electronic Cigarette without nicotine
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: SINGLE (PARTICIPANT)|Primary Purpose: BASIC_SCIENCE
Clinical trial: Irinotecan Plus Raltitrexed in Treating Patients With Refractory Solid Tumors
Status: COMPLETED
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: irinotecan hydrochloride|DRUG: raltitrexed
Study Type: INTERVENTIONAL
Study Design: Allocation: |Intervention Model: |Masking: |Primary Purpose: TREATMENT
Clinical trial: Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
Status: COMPLETED
Conditions: B-cell Adult Acute Lymphoblastic Leukemia (ALL)|Ph-positive Adult Acute Lymphoblastic Leukemia (ALL)|Recurrent Adult Acute Lymphoblastic Leukemia (ALL)|T-cell Adult Acute Lymphoblastic Leukemia (ALL)
Interventions: DRUG: Bortezomib|DRUG: Doxorubicin hydrochloride (HCl)|DRUG: PEG-Asparaginase|DRUG: Vincristine sulfate|DRUG: Dexamethasone|DRUG: Cytarabine|DRUG: Methotrexate
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis
Status: COMPLETED
Conditions: Chronic Kidney Disease Requiring Chronic Dialysis
Interventions: DRUG: Furosemide (loop diuretic) Tablets
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Assessment of Safety and Preliminary Clinical Efficacy With BAT6005 in Advanced Malignant Solid Tumors
Status: RECRUITING
Conditions: Locally Advanced or Metastatic Solid Tumors
Interventions: DRUG: BAT6005 injection
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SEQUENTIAL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Safety and Efficacy of Olopatadine Hydrochloride/Ketorolac Tromethamine Ophthalmic Solution Compared With Olopatadine Hydrochloride Ophthalmic Solution in Patients With Seasonal Allergic Conjunctivitis
Status: COMPLETED
Conditions: Rhinitis, Allergic, Seasonal|Conjunctivitis, Allergic
Interventions: DRUG: olopatadine hydrochloride /ketorolac tromethamine fixed dose combination ophthalmic solution|DRUG: olopatadine hydrochloride 0.1% ophthalmic solution
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: A Phase 1, Randomized, Placebo-and Positive-Controlled Crossover Study to Determine the Effect of Single-Dose GC4419 on QTc Interval in Healthy Volunteers
Status: COMPLETED
Conditions: Healthy Volunteers|Healthy
Interventions: DRUG: GC4419 IV|DRUG: Placebo|DRUG: Oral moxifloxacin
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: CROSSOVER|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Kinematics of Ewing Amputees
Status: ENROLLING_BY_INVITATION
Conditions: Lower Extremity Amputation|Trans-Tibial Amputation|Traumatic Lower Extremity Amputation|Agonist-Antagonist Myoneural Interface
Interventions: PROCEDURE: Modified Amputation|PROCEDURE: Standard Amputation
Study Type: OBSERVATIONAL
Study Design: Observational Model: |Time Perspective: p
Clinical trial: Effects of Acipimox on Mitochondrial Function in Obesity
Status: COMPLETED
Conditions: Abdominal Obesity|Insulin Resistance|Hypertriglyceridemia
Interventions: DRUG: Acipimox|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma
Status: COMPLETED
Conditions: Rectal Cancer|Rectal Adenocarcinoma
Interventions: DRUG: Lenvatinib|DRUG: Capecitabine|RADIATION: External Radiation Therapy (XRT)
Study Type: INTERVENTIONAL
Study Design: Allocation: NA|Intervention Model: SINGLE_GROUP|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: ''The Effect of Skin-to-Skin Contact and Gentle Touch Method Applied During Blood Collection on Early Detection of Pain and Physiological Parameters''
Status: COMPLETED
Conditions: Venipuncture|Pain|Touch
Interventions: OTHER: Skin To Skin|BEHAVIORAL: Gentle Human Touch
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: PREVENTION
Clinical trial: Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Anxiety
Status: COMPLETED
Conditions: Anxiety
Interventions: DEVICE: VeNS
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: First in Human of Single and Multiple Doses of MOR106
Status: COMPLETED
Conditions: Healthy|Dermatitis, Atopic
Interventions: DRUG: MOR106 single ascending doses, intravenous|DRUG: Placebo single ascending doses, intravenous|DRUG: MOR106 multiple ascending doses, intravenous|DRUG: Placebo multiple intravenous administrations
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: QUADRUPLE (PARTICIPANT, CARE_PROVIDER, INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Maximizing Outcomes in Treating Acute Migraine
Status: COMPLETED
Conditions: Migraine
Interventions: DRUG: AXS-07 (MoSEIC meloxicam and rizatriptan)|DRUG: Meloxicam|DRUG: Rizatriptan|DRUG: Placebo
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (PARTICIPANT, INVESTIGATOR)|Primary Purpose: TREATMENT
Clinical trial: Exercise and Respiratory Therapy in Patients With Rheumatoid Arthritis / Collagenosis and Pulmonary Hypertension
Status: UNKNOWN
Conditions: Pulmonary Hypertension|Connective Tissue Disease
Interventions: BEHAVIORAL: exercise training
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: NONE|Primary Purpose: TREATMENT
Clinical trial: Effects of Motor Cognitive Training on Functional Loss After Osteoporotic Wrist Fractures
Status: COMPLETED
Conditions: Osteoporotic Distal Radius Fracture
Interventions: BEHAVIORAL: motor cognitive therapies
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: DOUBLE (INVESTIGATOR, OUTCOMES_ASSESSOR)|Primary Purpose: TREATMENT
Clinical trial: Bullying Prevention Intervention for Adolescent Primary Care Patients
Status: COMPLETED
Conditions: Cyberbullying
Interventions: BEHAVIORAL: iPACT Intervention|OTHER: Control: Enhanced Usual Care (EUC)|BEHAVIORAL: iPACT Intervention- app
Study Type: INTERVENTIONAL
Study Design: Allocation: RANDOMIZED|Intervention Model: PARALLEL|Masking: SINGLE (OUTCOMES_ASSESSOR)|Primary Purpose: PREVENTION